title: [Impact of drug molecules on HP-β-CD compound inclusion].
abstract: To study the interaction of drugs of different properties, namely puerarin, borneol and catalpol in the process of in- clusion, in order to explore the inclusion regularity of multi-component and multi-property traditional Chinese medicine compound in- clusions. With HP-β-CD as the inclusion material, the freeze-drying method was used to prepare the inclusion. The inclusion between puerarin, borneol and catalpol was tested by measuring the inclusion concentration, DSC and X-ray diffraction. According to the find- ings, when insoluble drugs puerarin and borneol were included simultaneously, and puerarin was overdosed, puerarin included was almost equal to puerarin included, and borneol was not included. When puerarin was under-dosed, and HP-β-CD was overdosed, borne- ol was included, and the simultaneous inclusion was lower than the separate inclusion of borneol. When water-soluble drug catalpol was jointly included with puerarin or borneol, the simultaneous inclusion was almost the same with their separate inclusion, without charac- teristic peak of catalpol in DSC and X-ray diffraction patterns. There is a competition in the simultaneous inclusion between water-solu- ble drugs puerarin and borneol and a stronger competition in puerarin. The water-soluble drug catalpol could be included with HP-β-CD with no impact on the inclusion of puerarin or borneol.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Tang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Wang
authors.forename: Ji-Fen
authors.initials: JF
authors.lastname: Zhang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Xu
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002545:Brain Ischemia / Q000188:drug therapy; D001892:Camphanes / Q000737:chemistry* / Q000627:therapeutic use; D004339:Drug Compounding / Q000379:methods*; D005612:Freeze Drying; D057888:Iridoid Glucosides / Q000737:chemistry* / Q000627:therapeutic use; D007529:Isoflavones / Q000737:chemistry* / Q000627:therapeutic use; D012995:Solubility; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001892:Camphanes; D057888:Iridoid Glucosides; D007529:Isoflavones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C078040:catalpol; C022871:isoborneol; C033607:puerarin