title: Design of smart oligo(ethylene glycol)-based biocompatible hybrid microgels loaded with magnetic nanoparticles.
abstract: This article reports a rational strategy for preparing smart oligo(ethylene glycol)-based hybrid microgels loaded with high content of homogeneously distributed preformed magnetic nanoparticles (NPs) (up to 33 wt%). The strategy is based on the synthesis of biocompatible multiresponsive microgels by precipitation copolymerization of di(ethylene glycol) methyl ether methacrylate, oligo(ethylene glycol) methyl ether methacrylate, methacrylic acid, and oligo(ethylene glycol)diac-rylate. An aqueous dispersion of preformed magnetic NPs is straightforwardly loaded into the microgels. Robust monodisperse thermoresponsive magnetic microgels are produced, exhibiting a constant value of the volume phase transition temperature whatever the NPs content. The homogeneous microstructure of the initial stimuli-responsive biocompatible microgels plays a crucial role for the design of unique well-defined ethylene glycol-based thermoresponsive hybrid microgels.
authors.affiliation: CNRS, Université de Pau & Pays Adour, UMR 5254, IPREM, Equipe de Physique et Chimie des Polymères, 2 avenue du Président Angot, Pau, F-64053, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Boularas
authors.forename: Emilie
authors.initials: E
authors.lastname: Gombart
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tranchant
authors.forename: Laurent
authors.initials: L
authors.lastname: Billon
authors.forename: Maud
authors.initials: M
authors.lastname: Save
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D005782:Gels; D053768:Metal Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D005290:Ferric Compounds; D005782:Gels; C000499:ferric oxide; D011092:Polyethylene Glycols
keywords: hybrid materials; magnetic nanoparticles; microgels; polymerization; stimuli-responsive