title: Direct and metal-free arylsulfonylation of alkynes with sulfonylhydrazides for the construction of 3-sulfonated coumarins.
abstract: A novel and metal-free procedure has been developed for the construction of 3-sulfonated coumarins via the direct difunctionalization of alkynoates with sulfonylhydrazides. The present protocol, which simply utilizes TBAI as the catalyst and TBHP as the oxidant, provides a convenient and highly efficient approach to construct a series of sulfonated coumarins with high regioselectivity and good functional group tolerance.
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China. huawang_qfnu@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Wen
authors.forename: Daoshan
authors.initials: D
authors.lastname: Yang
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Guo
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinmao
authors.initials: J
authors.lastname: You
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D003374:Coumarins; D006834:Hydrazines; D016877:Oxidants; D013450:Sulfones