title: Shortened telomere in unremitted schizophrenia.
abstract: OBJECTIVE
  Telomere attrition has been noted in many neuropsychiatric and neurodegenerative syndromes, and may indicate a shared molecular pathology across conditions. We evaluated telomere length in subjects with remitted and unremitted schizophrenia and in control subjects.
  
  
  METHODS
  We measured telomere length as relative telomere/single-copy gene ratios in subjects with schizophrenia (n = 71) using quantitative real-time polymerase chain reaction. This was compared with relative telomere/single-copy gene ratios in age-matched controls without neuropsychiatric illness (n = 73).
  
  
  RESULTS
  The relative telomere/single-copy gene ratios were significantly lower in subjects with unremitted schizophrenia when compared with control subjects (r = -0.281, P = 0.003), as well as the individuals with remitted schizophrenia.
  
  
  CONCLUSIONS
  The lower relative telomere length in unremitted schizophrenia subjects may thus indicate shared biological pathways with other neurodegenerative disorders that are also characterized by increased cellular senescence.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Lakshmi Narayanan
authors.initials: LN
authors.lastname: Kota
authors.forename: Meera
authors.initials: M
authors.lastname: Purushottam
authors.forename: Nagaraj S
authors.initials: NS
authors.lastname: Moily
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Jain
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D012074:Remission Induction; D012559:Schizophrenia / Q000235:genetics*; D059506:Telomere Shortening / Q000235:genetics*; D055815:Young Adult
keywords: biological psychiatry; genetics in psychiatry; real-time polymerase chain reaction; schizophrenia; telomere shortening