title: Use of epigenetic modulators as a powerful adjuvant for breast cancer therapies.
abstract: Breast cancer (BC) is one of the five most frequent cancers in the world. Despite earlier diagnosis and development of specific treatments, mortality has only declined of about 30 % during the past two decades. Two of the main reasons are the emergence of drug resistance and the absence of specific therapy for triple negative breast cancers (TNBC), which are characterized by a poor prognosis due to high proliferation rate. Therefore, the future goal of the fight against BC will be to find new therapeutic approaches to overcome drug resistances and cure TNBC. Recent research on gene expression profiles linked to the different types of BC cells have led to consider the use of epigenetic modulators to modulate the expression of genes deregulated in cancer. The preliminary encouraging results have demonstrated a positive effect of DNA Methyl Transferase (DNMT) and Histone DeAcetylase (HDAC) inhibitors on different types of BC, as well as drug-resistant cells, with low side effects. In this review, we will describe the different epigenetic modulators currently used or investigated in BC therapy research in vitro as well as preclinical and clinical trials, and promising compounds, which might be used in future BC therapies.
authors.affiliation: Laboratoire de Biochimie, Equipe EA3922. Estrogènes, expression génique et pathologies du système nerveux central, Batiment DF, UFR-ST, Université de Franche-Comté, 16, Route de Gray, 25030, Besançon Cedex, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Claude-Taupin
authors.forename: Michael
authors.initials: M
authors.lastname: Boyer-Guittaut
authors.forename: Régis
authors.initials: R
authors.lastname: Delage-Mourroux
authors.forename: Eric
authors.initials: E
authors.lastname: Hervouet
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors; D055808:Drug Discovery; D044127:Epigenesis, Genetic / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans
chemical_list: D000277:Adjuvants, Pharmaceutic; D056572:Histone Deacetylase Inhibitors; D004248:DNA (Cytosine-5-)-Methyltransferases