title: Uncoupling protein 2 gene (UCP2) 45-bp I/D polymorphism is associated with adiposity among Malaysian women.
abstract: This study investigated the association of Uncoupling Protein 2 gene (UCP2) 45-bp I/D polymorphism with obesity and adiposity in 926 Malaysian subjects (416 males;265 obese; 102/672/152 Malays/Chinese/Indians). The overall minor allele frequency (MAF) was 0.14, while MAFs according to Malay/Chinese/Indian were 0.17/0.12/0.21. The polymorphism was associated with ethnicity, obesity and overall adiposity (total body fat percentage, TBF), but not gender and central adiposity (waist-hip ratio, WHR). Gender- and ethnicity-stratified analysis revealed that within males, the polymorphism was not associated with ethnicity and anthropometric classes. However, within females, significantly more Indians, obese and those with high TBF carried I allele. Logistic regression analysis among females further showed the polymorphism was associated with obesity and overall adiposity; however, when adjusted for age and ethnicity, this association was abolished for obesity but remained significant for overall adiposity [Odds Ratio (OR) for ID genotype = 2.02 (CI=1.18, 3.45; p=0.01); I allele =1.81 (CI=1.15, 2.84; p=0.01)]. Indeed, covariate analysis controlling for age and ethnicity also showed that those carrying ID genotype or I allele had significantly higher TBF than the rest. In conclusion, UCP2 45-bp I/D polymorphism is associated with overall adiposity among Malaysian women.
authors.affiliation: Department of Biomedical Science, Faculty of Science, Centre for Foundation Studies, Universiti Tunku Abdul Rahman (UTAR) Perak Campus, Kampar, Perak, Malaysia, sayyh@utar.edu.my.
authors.forename: Yee-How
authors.initials: YH
authors.lastname: Say
authors.forename: Zi-Lian
authors.initials: ZL
authors.lastname: Ban
authors.forename: Yogambigai
authors.initials: Y
authors.lastname: Arumugam
authors.forename: Trishal
authors.initials: T
authors.lastname: Kaur
authors.forename: Mee-Lay
authors.initials: ML
authors.lastname: Tan
authors.forename: Phee-Phee
authors.initials: PP
authors.lastname: Chia
authors.forename: Sook-Ha
authors.initials: SH
authors.lastname: Fan
mesh_terms: D050154:Adiposity / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008296:Malaysia; D024101:Mitochondrial Proteins / Q000235:genetics*; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2