title: Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy.
abstract: Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin, and sorafenib tosylate have been prepared by the emulsion solvent evaporation method with diameter between 200 and 400 μm. Scanning electron microscopy showed that cisplatin microspheres had smooth surfaces, while sorafenib tosylate microspheres and cisplatin + sorafenib tosylate microspheres were porous at the surface and the pits of the latter were larger than those of the former. Notably, cisplatin + sorafenib tosylate microspheres had a fast drug release rate compared with microspheres containing one drug alone. In vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively. This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization.
authors.affiliation: a Faculty of Health, Medicine and Life Sciences, Department of Biomedical Engineering/Biomaterials Sciences , Maastricht University , Maastricht , The Netherlands.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Wang
authors.forename: Abderazak
authors.initials: A
authors.lastname: Benzina
authors.forename: Daniel G M
authors.initials: DG
authors.lastname: Molin
authors.forename: Nynke van den
authors.initials: Nv
authors.lastname: Akker
authors.forename: Mick
authors.initials: M
authors.lastname: Gagliardi
authors.forename: Leo H
authors.initials: LH
authors.lastname: Koole
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D016461:Chemoembolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D004347:Drug Interactions; D065546:Drug Liberation; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D010671:Phenylurea Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D011091:Polyesters; D011108:Polymers; D016062:Porosity; D011859:Radiography; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D011091:Polyesters; D011108:Polymers; D009536:Niacinamide; D019344:Lactic Acid; C033616:poly(lactide); D000077157:Sorafenib; D002945:Cisplatin
keywords: TACE; biodegradable; drug release; microspheres; sorafenib tosylate; tumor embolization