title: Fish consumption and risk of non-Hodgkin lymphoma: A meta-analysis of observational studies.
abstract: Objectives:Whether a relationship between fish consumption and non-Hodgkin lymphoma (NHL) risk exists is an open issue. We carried out a meta-analysis to explore this association according to the published observational studies.Methods:We performed a search of databases in MEDLINE and EMBASE to identify relevant studies. We derived meta-analytic estimates using random-effects models, and assessed between-study heterogeneity using the Cochran'sQandI2statistics.Results:We identified a total of seven case-control and two prospective cohort studies, including 7696 subjects with NHL. The summary relative risks (SRRs) estimated for NHL were 0.80 (95% confidence intervals (CIs): 0.68-0.94) for those in the highest fish consumption category compared with those in the lowest consumption category. There was evidence of significant heterogeneity across studies (Q= 26.72,Pheterogeneity= 0.002,I2= 66.3%). Stratified analysis by study design indicated that a significant risk association between fish consumption and NHL was observed in case-control studies, but not in cohort studies. Based on the dose-response meta-analysis, the SRRs of NHL were 0.85 (95% CIs: 0.71-1.01) for three servings increased per week of fish consumed with evidence of significant heterogeneity (Pheterogeneity= 0.007,I2= 63.9%).Conclusions:Findings from our meta-analysis indicate that consumption of fish may be not related to NHL risk.
authors.affiliation: First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, China.|Hematology Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Hematology Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Shi
authors.affiliation: Nantong Cancer Hospital, Lymphoma Center, Nantong, Jiangsu, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Xu
authors.affiliation: Hematology Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Xin-Feng
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Hematology Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, China.
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects*; D005399:Fishes / Q000378:metabolism*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors
keywords: Dose–response analysis; Fish consumption; Meta-analysis; Non-Hodgkin lymphoma