title: Coronary artery disease in giant cell arteritis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To investigate the association between giant cell arteritis (GCA) and risk of coronary artery disease (CAD).
  
  
  METHODS
  We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, or standardized incidence ratios with 95% confidence interval comparing CAD risk in patients with GCA versus non-GCA controls. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.
  
  
  RESULTS
  Six studies with 10,868 patients with GCA and 245,323 controls were identified and included in our data analysis. The pooled risk ratio of CAD in patients with GCA was 1.51 and did not achieve statistical significance (95% CI: 0.88-2.61). The statistical heterogeneity was high with an I(2) of 97%.
  
  
  CONCLUSIONS
  In contrast to other chronic systemic inflammatory disorders, our meta-analysis did not show any statistically significant increased risk of CAD among patients with GCA.
authors.affiliation: Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905. Electronic address: Ungprasert.Patompong@mayo.edu.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Koster
authors.affiliation: Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Warrington
mesh_terms: D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology*; D013700:Giant Cell Arteritis / Q000150:complications*; D006801:Humans; D015994:Incidence
keywords: Coronary artery disease; Epidemiology; Giant cell arteritis; Meta-analysis