title: Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?
abstract: Acute liver failure (ALF) is a rapidly progressing critical illness with a high mortality rate. Circulating inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), play a significant role in the pathophysiology of ALF through promoting hepatocellular apoptosis. Ginsenoside Rg1, the primary active ingredient in Panax ginseng (also termed Asian or Korean ginseng), has been reported to inhibit TNF-α production and has been shown to significantly attenuate liver fibrosis development. Here, we assessed ginsenoside Rg1's potential as a therapy for ALF by investigating the effect of ginsenoside Rg1 treatment on circulating inflammatory markers, hepatocellular apoptosis, and relevant apoptotic signaling pathways in a well-established murine ALF model. We found that ginsenoside Rg1 significantly reduces liver damage in a murine ALF model through inhibiting TNF-α-induced, caspase-dependent hepatocellular apoptosis. These results support the further investigation of ginsenoside Rg1 as a therapeutic candidate for ALF.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China.
authors.forename: Jinqiu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Huang