title: Chemical composition and antioxidant activity of a polar extract of Thymelaea microphylla Coss. et Dur.
abstract: Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) is a rare medicinal plant endemic to Algeria. In order to continue our studies on this species, herein we report the isolation and characterisation of 20 compounds from a hydroalcoholic extract (EtOH-H2O 7:3) of the aerial parts. They include monoterpene glucosides (1-3), phenolic acid derivatives (4, 8 and 9), phenylpropanoid glucosides (5 and 6), flavonoids (7, 10 and 11), a benzyl alcohol glucoside (12), ionol glucosides (13-16), lignans (17-19) and a bis-coumarin (20). All the structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. Moreover, the extract of T. microphylla showed a significant and concentration-dependent free radical-scavenging activity in vitro, correlated to the presence of phenolic and chlorogenic acid derivatives (8, 9 and 4).
authors.affiliation: a Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1 , Route de Aïn El Bey, Constantine , Algérie.
authors.forename: Khawla
authors.initials: K
authors.lastname: Kerbab
authors.forename: Tarak
authors.initials: T
authors.lastname: Mekhelfi
authors.forename: Lahcene
authors.initials: L
authors.lastname: Zaiter
authors.forename: Samir
authors.initials: S
authors.lastname: Benayache
authors.forename: Fadila
authors.initials: F
authors.lastname: Benayache
authors.forename: Patrizia
authors.initials: P
authors.lastname: Picerno
authors.forename: Teresa
authors.initials: T
authors.lastname: Mencherini
authors.forename: Francesca
authors.initials: F
authors.lastname: Sansone
authors.forename: Rita P
authors.initials: RP
authors.lastname: Aquino
authors.forename: Luca
authors.initials: L
authors.lastname: Rastrelli
mesh_terms: D003374:Coumarins / Q000032:analysis; D005419:Flavonoids / Q000032:analysis; D016166:Free Radical Scavengers / Q000032:analysis*; D005960:Glucosides / Q000032:analysis; D015394:Molecular Structure; D010636:Phenols / Q000032:analysis*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D003374:Coumarins; D005419:Flavonoids; D016166:Free Radical Scavengers; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C030123:coumarin
keywords: Thymelaea microphylla; bis-coumarin; free radical-scavenging activity; ionol glucosides; lignans; monoterpenes; polyphenols