title: The direct α-C(sp(3))-H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing.
abstract: An efficient nitro-Mannich type direct α-C(sp(3))-H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.
authors.affiliation: CSIRO Manufacturing Flagship, Bayview Avenue, Clayton 3168, Victoria, Australia. tash.polyzos@csiro.au.
authors.forename: Martin
authors.initials: M
authors.lastname: Brzozowski
authors.forename: Jose A
authors.initials: JA
authors.lastname: Forni
authors.forename: G
authors.initials: G
authors.lastname: Paul Savage
authors.forename: Anastasios
authors.initials: A
authors.lastname: Polyzos