title: No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health - results from the Danish Blood Donor Study.
abstract: The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. Low-grade inflammation (LGI) and self-reported, health-related quality of life (HRQL) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T-allele in rs6897932 is associated with reduced risk of LGI (hsCRP 3-10 mg/L), history of infectious mononucleosis (IM), and HRQL in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of LGI, self-reported IM, and HRQL in univariable and multivariable models stratified by sex. No associations between rs6897932 and LGI, self-reported IM or HRQL were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T-allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system.
authors.affiliation: Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Hartling
authors.forename: Cecilie J
authors.initials: CJ
authors.lastname: Sørensen
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Rigas
authors.forename: Kristoffer S
authors.initials: KS
authors.lastname: Burgdorf
authors.forename: Susanne D
authors.initials: SD
authors.lastname: Nielsen
authors.forename: Ole B
authors.initials: OB
authors.lastname: Pedersen
authors.forename: Mikkel S
authors.initials: MS
authors.lastname: Petersen
authors.forename: Erik
authors.initials: E
authors.lastname: Sørensen
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kotzé
authors.forename: Lise W
authors.initials: LW
authors.lastname: Thørner
authors.forename: Henrik
authors.initials: H
authors.lastname: Hjalgrim
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
mesh_terms: D000328:Adult; D000483:Alleles; D002097:C-Reactive Protein / Q000378:metabolism; D003718:Denmark; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007244:Infectious Mononucleosis / Q000235:genetics* / Q000276:immunology; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D057566:Self Report; D011795:Surveys and Questionnaires
chemical_list: D053699:Interleukin-7 Receptor alpha Subunit; D002097:C-Reactive Protein
keywords: Infectious mononucleosis; health-related quality of life; inflammation; interleukin-7 receptor alpha; lowgrade; rs6897932; self-reported