title: Phylogenetic analysis of canine distemper virus in domestic dogs in Nanjing, China.
abstract: Canine distemper virus (CDV) infects a broad range of carnivores, including wild and domestic Canidae. The hemagglutinin gene, which encodes the attachment protein that determines viral tropism, has been widely used to determine the relationship between CDV strains of different lineages circulating worldwide. We determined the full-length H gene sequences of seven CDV field strains detected in domestic dogs in Nanjing, China. A phylogenetic analysis of the H gene sequences of CDV strains from different geographic regions and vaccine strains was performed. Four of the seven CDV strains were grouped in the same cluster of the Asia-1 lineage to which the vast majority of Chinese CDV strains belong, whereas the other three were clustered within the Asia-4 lineage, which has never been detected in China. This represents the first record of detection of strains of the Asia-4 lineage in China since this lineage was reported in Thailand in 2013.
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China, bizhenwei@126.com.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Bi
authors.forename: Yongshan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.forename: Xingxia
authors.initials: X
authors.lastname: Xia
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002681:China; D004216:Distemper / Q000821:virology; D004217:Distemper Virus, Canine / Q000145:classification* / Q000235:genetics; D004285:Dogs / Q000821:virology*; D006389:Hemagglutinins, Viral / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D058974:Phylogeography; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D006389:Hemagglutinins, Viral