title: Vaginal microbiota and sexually transmitted infections that may influence transmission of cell-associated HIV.
abstract: Vaginal microbiota and sexually transmitted infections (STIs) are likely to influence the transmission of cell-associated human immunodeficiency virus (HIV). Lactic acid produced by Lactobacillus-dominated microbiota (Nugent score 0-3) will likely inhibit transmission, especially female-to-male transmission. In contrast, polymicrobial microbiota (Nugent score 4-10), community state types IV-A and IV-B, and STIs will likely increase transmission of cell-associated HIV.
authors.affiliation: Department of Biophysics, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Cone
mesh_terms: D005260:Female; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D007778:Lactobacillus / Q000502:physiology; D007962:Leukocytes / Q000502:physiology; D008297:Male; D064307:Microbiota / Q000502:physiology; D012749:Sexually Transmitted Diseases / Q000150:complications*; D014621:Vagina / Q000382:microbiology / Q000821:virology; D014623:Vaginal Diseases / Q000150:complications* / Q000382:microbiology / Q000821:virology
chemical_list: D019344:Lactic Acid
keywords: cell-associated HIV; inflammatory cytokines; lactic acid; polymicrobial microbiota