title: Will Multi-Parametric Magnetic Resonance Imaging be the Future Tool to Detect Clinically Significant Prostate Cancer?
abstract: Multi-parametric magnetic resonance imaging is an emerging imaging modality for diagnosis, staging, characterization, and treatment planning of prostate cancer. In this report, we reviewed the literature for studies assessing the accuracy of multi-parametric magnetic resonance imaging in detecting clinically significant prostate cancer, and we critically examined the future role of this imaging tool in various clinical diagnostic settings. There is accumulating evidence suggesting a high accuracy of multi-parametric magnetic resonance imaging in ruling out clinically significant disease. Although definition for clinically significant disease widely varies, the negative predictive value is very high at up to 98%. Multi-parametric magnetic resonance imaging should, thus, be further evaluated for application in different clinical scenarios in which it is desirable to reduce the proportion of unnecessary prostate biopsies and to limit the detection of indolent disease, such as opportunistic screening, persistent prostate cancer suspicion in men with previous negative prostate biopsies, and eligibility for active surveillance. Continued improvement in standardization of technical parameters, functional sequences, and image reporting systems is a pre-requisite for a rapid and successful dissemination of this imaging modality.
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Giannarini
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Zazzara
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Rossanese
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Palumbo
authors.affiliation: Department of Medical and Biological Sciences, Institute of Diagnostic Radiology, University of Udine , Udine , Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Pancot
authors.affiliation: Department of Medical and Biological Sciences, Institute of Diagnostic Radiology, University of Udine , Udine , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Como
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Abbinante
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Urology Unit, University of Udine , Udine , Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ficarra
keywords: active surveillance; magnetic resonance imaging; prostate biopsy; prostate neoplasms; radical prostatectomy; screening