title: Hodgkin-like peripheral T-cell lymphoma (PTCL) with preserved Hodgkin-like lesions at autopsy: a case report with an interesting clinical course.
abstract: The presence of the so-called Hodgkin and Reed-Sternberg (H-RS) like cells may occur in T-cell non-Hodgkin lymphoma. Reported herein is the autopsy case of Hodgkin-like peripheral T-cell lymphoma (PTCL) in a 77-year-old male with gradual submandibular lymph node enlargement. The first biopsy showed Hodgkin-like PTCL, initially misdiagnosed as classical Hodgkin lymphoma. Although he was treated with a regimen of ABVD, his disease recurred with cervical lymph node enlargement. A second biopsy showed angioimmunoblastic T-cell lymphoma (AITL) and H-RS like cells became obscure. Despite treatment with the CHOP regimen, he died. An autopsy confirmed that only Hodgkin-like lesions preserved while the AITL component had disappeared. This clinical course is very interesting in that only the Hodgkin-like lesions were systematically exacerbated and became the main cause of death. There are no reports of Hodgkin-like PTCL following AITL and finally preserved Hodgkin-like lesions in autopsy.
authors.affiliation: Department of Pathology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan; Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan. Electronic address: mori-d@koseikan.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mori
authors.affiliation: Department of Hematology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Eijo
authors.initials: E
authors.lastname: Matsuishi
authors.affiliation: Department of Pathology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Akashi
authors.affiliation: Department of Pathology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Shibaki
authors.affiliation: Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hirano
authors.affiliation: Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Ide
authors.affiliation: Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tsutsumi
authors.affiliation: Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tsukiji
authors.affiliation: Department of Hematology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gondo
mesh_terms: D000368:Aged; D001344:Autopsy; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology*
keywords: Autopsy; Epstein-Barr virus; Hodgkin-like peripheral T-cell lymphoma