title: Health-related quality of life in patients who develop bronchiolitis obliterans syndrome following allo-SCT.
abstract: Bronchiolitis obliterans syndrome (BOS) remains an important complication following allo-SCT. The development of this condition portends a higher morbidity and mortality but the effect on heath-related quality of life (HRQL) is unknown. The aim of this study was to determine whether the development of BOS impacted HRQL compared with patients without BOS. This Institutional Review Board-approved prospective study analyzed 126 patients who underwent allo-SCT at our institution. Patients were administered three HRQL survey tools (SF-36, European Organization for Research and Treatment of Cancer QLQ-c30 and St George Respiratory Questionnaire (SGRQ)) before transplant and then again at 6 months, 1 year and 2 years after transplant. Patients were analyzed in three groups determined by highest chronic GVHD (cGVHD) severity and BOS status. Overall, our study group had improving HRQL after transplant when measured over time, measured by the SF-36 with stable HRQL, when measured by the SGRQ total score and QLQ-c30. Patients that developed BOS had significantly worse HRQL scores measured by the SGRQ and the SF-36 physical composite score. This difference was not explained by the severity of cGVHD that patients with BOS developed.
authors.affiliation: Division of Pulmonary, Department of Medicine, Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Amin
authors.affiliation: The Ohio State University Center for Biostatistics, Columbus, OH, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Phillips
authors.affiliation: Division of Hematology/ Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA.
authors.forename: P
authors.initials: P
authors.lastname: Elder
authors.affiliation: Division of Hematology/ Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA.
authors.forename: S
authors.initials: S
authors.lastname: Jaglowski
authors.affiliation: Division of Hematology/ Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Devine
authors.affiliation: Division of Pulmonary, Department of Medicine, Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Wood
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D001989:Bronchiolitis Obliterans / Q000453:epidemiology* / Q000209:etiology; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D033581:Stem Cell Transplantation; D011795:Surveys and Questionnaires