title: [New Developments in CKD-MBD. Molecular mechanisms of intestinal and renal phosphate transport].
abstract: Intestinal inorganic phosphate (Pi) absorption and renal Pi reabsorption are regulated by parathyroid hormone, fibroblast growth factor 23, or 1,25-dihydroxyvitamin D, which modulate the expression of Pi transporters. Identification, functional characterization and analysis of knockout mice of Pi transporters contributed to clarify the role of each transporter in Pi homeostasis. Furthermore, the molecular mechanisms will lead to the development of new pharmaceutical research approaches.
authors.affiliation: Department of Molecular Nutrition, Institute of Health Bioscience, University of Tokushima Graduate School, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Segawa
authors.forename: Kayo
authors.initials: K
authors.lastname: Ikuta
authors.forename: Kenichi
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D017920:Antiporters / Q000378:metabolism*; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism*; D065569:Gastrointestinal Absorption; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*
chemical_list: D017920:Antiporters; D010710:Phosphates