title: Congenital cytomegalovirus infection is a significant cause of moderate to profound sensorineural hearing loss in Queensland children.
abstract: OBJECTIVE
  To investigate the proportion of children with moderate to profound hearing loss who have congenital cytomegalovirus (cCMV) infection.
  
  
  METHODS
  Retrospective analysis of CMV dried blood spot (DBS) polymerase chain reaction (PCR) in children with moderate to profound hearing impairment referred to tertiary referral centres in Queensland. Participants were under 18 years old with no readily identified cause of hearing impairment, between 2008 and 2011. The primary outcome measure was DBS CMV PCR. Other outcome measures for cases referred to the Childhood Hearing Clinic (CHC) at the Mater Children's Hospital were level of hearing impairment and the neonatal hearing screen result.
  
  
  RESULTS
  Of DBS CMV PCR testing for 106 children at the CHC for 2008 to 2011 inclusive, nine (8.5%) were positive (five with bilateral hearing impairment, four with unilateral hearing impairment). The prevalence of cCMV infection in children with moderate to profound hearing impairment was 8.4%, consistent with the statewide rate of 9.4% for 2008 to mid-2011.
  
  
  CONCLUSIONS
  cCMV is a significant cause of hearing impairment in Queensland children. Investigation for cCMV by retrospective DBS CMV PCR should be part of the routine investigation of all babies and young children with hearing impairment. However early diagnosis is preferable and could be achieved by routine early screening of all newborns with hearing impairment for CMV before 3 weeks of age. The healthy hearing screening programme is a routine part of neonatal care. Enhancing the integration of screening for cCMV may reduce the current delays in diagnosis and should be evaluated.
authors.affiliation: Department of Paediatrics, Mater Children's Hospital, South Brisbane, Queensland, Australia.|Department of Paediatrics, Greenslopes Private Hospital, South Brisbane, Queensland, Australia.|School of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Toumpas
authors.affiliation: Department of Paediatrics, Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia.|Department of Paediatrics, University of Queensland, South Brisbane, Queensland, Australia.
authors.forename: Julia
authors.initials: J
authors.lastname: Clark
authors.affiliation: Department of Paediatrics, Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia.|Department of Paediatrics, University of Queensland, South Brisbane, Queensland, Australia.
authors.forename: Alison
authors.initials: A
authors.lastname: Harris
authors.affiliation: Health Services Support Agency, Brisbane, Queensland, Australia.
authors.forename: Rachael
authors.initials: R
authors.lastname: Beswick
authors.affiliation: Department of Paediatrics, Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia.|Department of Paediatrics, University of Queensland, South Brisbane, Queensland, Australia.
authors.forename: Clare B
authors.initials: CB
authors.lastname: Nourse