title: Two new triterpenoid saponins obtained by microbial hydrolysis with Alternaria alternata AS 3.6872.
abstract: Compound 1, a triterpenoid saponin from Ardisia gigantifolia Stapf showing potential anti-tumour activity, was hydrolysed into two deglycosyl derivatives (2 and 3) by Alternaria alternata AS 3.6872. Both these derivatives are new compounds. Their structures were elucidated on the basis of 1D, 2D NMR, HR-ESI-MS and optical rotation spectral data. Compounds 1-3 were evaluated for their cytotoxicity against human hepatocellular carcinoma and normal liver cells by Cell Counting Kit 8 colorimetric assay.
authors.affiliation: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mu
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Gu
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000528:Alternaria / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes
keywords: Alternaria alternata AS 3.6872; Ardisia gigantifolia Stapf; biotransformation; triterpenoid saponin