title: The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole.
abstract: The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.
authors.affiliation: School of Chemical Engineering & the Environment, Beijing Institute of Technology, 5 South Zhongguancun street, Haidian district, Beijing 100081, China. fuxue.chen@bit.edu.cn.
authors.forename: Yao-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Jiashen
authors.initials: J
authors.lastname: Qiu
authors.forename: Dejie
authors.initials: D
authors.lastname: Kong
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Gao
authors.forename: Feipeng
authors.initials: F
authors.lastname: Lu
authors.forename: Pran Gopal
authors.initials: PG
authors.lastname: Karmaker
authors.forename: Fu-Xue
authors.initials: FX
authors.lastname: Chen
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D004126:Dimethylformamide / Q000737:chemistry*; D004952:Esters / Q000737:chemistry
chemical_list: D003486:Cyanides; D004952:Esters; D004126:Dimethylformamide