title: Effect of biologically active substances derived from hydrobionts of the Pacific Ocean on parameters of lipid metabolism during experimental hypercholesterolemia.
abstract: We studied the effect of biologically active substances derived from hydrobionts, namely maristim (natural product from sea urchin roe) and fucolam (polysaccharides of fucoidan and calcium alginate from brown algae) on blood biochemistry in the mouse model of nutritional hypercholesterolemia. Maristim and fucolam are found to be capable to normalize the levels of the major indicators of lipid and carbohydrate metabolism and aminotransferase enzyme activity in terms of atherogenic load. Correction action of biologically active substances is more expressed in combined application. Identified experimentally normalizing effects of maristim and on lipid and carbohydrate metabolism allow us to recommend the further study in clinical trials of these biologically active substances and based on them additives.
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia, takuznets@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Kuznetsova
authors.forename: S P
authors.initials: SP
authors.lastname: Kryzhanovskii
authors.forename: L N
authors.initials: LN
authors.lastname: Bogdanovich
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000464:Alginates / Q000494:pharmacology; D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D001774:Blood Chemical Analysis; D050260:Carbohydrate Metabolism / Q000187:drug effects* / Q000502:physiology; D045424:Complex Mixtures / Q000494:pharmacology*; D004036:Diet, Atherogenic; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010140:Pacific Ocean; D000459:Phaeophyceae / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D012617:Sea Urchins / Q000737:chemistry; D000637:Transaminases / Q000378:metabolism
chemical_list: D000464:Alginates; D001688:Biological Products; D045424:Complex Mixtures; D006603:Hexuronic Acids; D011134:Polysaccharides; D020723:Glucuronic Acid; C007789:fucoidan; D000637:Transaminases