title: Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?
abstract: One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi.
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark rshe@food.dtu.dk.
authors.forename: Rene S
authors.initials: RS
authors.lastname: Hendriksen
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Pimlapas
authors.initials: P
authors.lastname: Leekitcharoenphon
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Foodborne, Waterborne, and Environmental Diseases, Enteric Diseases Laboratory Branch, Atlanta, Georgia, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Mikoleit
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Jacob Dyring
authors.initials: JD
authors.lastname: Jensen
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Rolf Sommer
authors.initials: RS
authors.lastname: Kaas
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Louise
authors.initials: L
authors.lastname: Roer
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Foodborne, Waterborne, and Environmental Diseases, Enteric Diseases Laboratory Branch, Atlanta, Georgia, USA.
authors.forename: Heena B
authors.initials: HB
authors.lastname: Joshi
authors.affiliation: National Institute of Health, Department of Medical Sciences, WHO National Salmonella and Shigella Center, Ministry of Public Health, Bangkok, Thailand.
authors.forename: Srirat
authors.initials: S
authors.lastname: Pornruangmong
authors.affiliation: National Institute of Health, Department of Medical Sciences, WHO National Salmonella and Shigella Center, Ministry of Public Health, Bangkok, Thailand.
authors.forename: Chaiwat
authors.initials: C
authors.lastname: Pulsrikarn
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Foodborne, Waterborne, and Environmental Diseases, Enteric Diseases Laboratory Branch, Atlanta, Georgia, USA.
authors.forename: Gladys D
authors.initials: GD
authors.lastname: Gonzalez-Aviles
authors.affiliation: Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: E Ascelijn
authors.initials: EA
authors.lastname: Reuland
authors.affiliation: Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands Ziekenhuis Groep Twente, Amsterdam, the Netherlands.
authors.forename: Nashwan
authors.initials: N
authors.lastname: Al Naiemi
authors.affiliation: Norwegian Institute of Public Health, Division of Infectious Disease Control, Department of Foodborne Infections, Oslo, Norway.
authors.forename: Astrid Louise
authors.initials: AL
authors.lastname: Wester
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Frank M
authors.initials: FM
authors.lastname: Aarestrup
authors.affiliation: Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hasman
mesh_terms: D004196:Disease Outbreaks; D016680:Genome, Bacterial; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D012485:Salmonella typhi / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D014195:Travel; D014435:Typhoid Fever / Q000453:epidemiology / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases