title: The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: a randomized prospective study.
abstract: OBJECTIVE
  Ecabet sodium (ES) is a new non-systemic anti-ulcer agent belonging to the category of gastroprotective agents. In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (LS) followed by ES with LS alone in treating endoscopic submucosal dissection (ESD)-induced iatrogenic gastric ulcers.
  
  
  METHODS
  Patients diagnosed with gastric adenomas or early gastric cancer were randomly divided into either the LS group (30 mg once daily for 4 weeks; n = 45) or the LS + ES group (LS 30 mg once daily for one week followed by ES 1500 mg twice daily for 3 weeks; n = 45). Four weeks after ESD, a follow-up endoscopy was conducted to evaluate the proportions of ulcer reduction and ulcer stages in the two groups.
  
  
  RESULTS
  In all, 79 patients were included in the final analyses. Both treatment modalities were well-tolerated in most patients, with a drug compliance of over 80%. There were no significant differences between the two groups in terms of the proportions of ulcer reduction (0.9503 ± 0.1215 in the LS group vs 0.9192 ± 0.0700 in the LS + ES group, P = 0.169) or ulcer stage (P = 0.446). The prevalence of adverse events related to drugs and bleeding were also similar between the two groups.
  
  
  CONCLUSIONS
  Sequential therapy with LS + ES is as effective as LS alone against ESD-induced gastric ulcers.
authors.affiliation: Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Ahn
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Choi
authors.forename: Jang Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Jeong Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Sae Kyung
authors.initials: SK
authors.lastname: Chang
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Han
mesh_terms: D045784:Abietanes / Q000008:administration & dosage*; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004210:Dissection / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery; D006801:Humans; D007049:Iatrogenic Disease; D064747:Lansoprazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000601:surgery; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology
chemical_list: D045784:Abietanes; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; C061681:ecabet
keywords: ecabet sodium; endoscopic submucosal dissection; lansoprazole; stomach neoplasm; stomach ulcer