title: Synthesis and olfactory characterization of silicon-containing derivatives of the acyclic lily-of-the-valley odorant 5,7,7-trimethyl-4-methylideneoctanal.
abstract: 5-Methyl-4-methylidene-6-(trimethylsilyl)hexanal (1b), a sila analog of the acyclic lily-of-the-valley odorant 5,7,7-trimethyl-4-methylideneoctanal (1a), and the Si-containing derivatives 2-6 were prepared in multistep syntheses, starting from Cl3 SiH and Cl2 SiMe2 , respectively. Compounds 1b, 2-6, and their new precursors were characterized by elemental analyses (C, H, N) and NMR spectroscopic studies ((1) H, (13) C, (15) N, and (29) Si). To gain more information about the structureodor correlation in the family of lily-of-the-valley or 'muguet' odorants, C/Si analogs 1a/1b and derivatives 2-6 were evaluated for their olfactory properties.
authors.affiliation: Universität Würzburg, Institut für Anorganische Chemie, Am Hubland, D-97074 Würzburg, (phone: +49-931-3185250; fax: +49-931-3184609).
authors.forename: Steffen
authors.initials: S
authors.lastname: Dörrich
authors.forename: Christoph
authors.initials: C
authors.lastname: Mahler
authors.forename: Reinhold
authors.initials: R
authors.lastname: Tacke
authors.forename: Philip
authors.initials: P
authors.lastname: Kraft
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D031405:Convallaria / Q000737:chemistry*; D015394:Molecular Structure; D009812:Odorants; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D017646:Organosilicon Compounds; D012825:Silicon
keywords: Hydrosilylation; Lily-of-the-valley odorants; Muguet odorants; Silicon-containing odorants