title: Chemical composition and anti-inflammatory activities of the essential oils from Acacia mearnsii de Wild.
abstract: The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography-mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p < 0.05) anti-inflammatory properties in the albumin-induced test model in rats. Oils from the fresh leaves and dry stems inhibited inflammation beyond 4 h post treatment. The potent anti-inflammatory activity of essential oils of A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases.
authors.affiliation: a Department of Chemistry , Faculty of Science and Agriculture, University of Fort Hare , Alice , South Africa.
authors.forename: Opeyemi N
authors.initials: ON
authors.lastname: Avoseh
authors.forename: Ope-oluwa O
authors.initials: OO
authors.lastname: Oyedeji
authors.forename: Kayode
authors.initials: K
authors.lastname: Aremu
authors.forename: Benedicta N
authors.initials: BN
authors.lastname: Nkeh-Chungag
authors.forename: Sandile P
authors.initials: SP
authors.lastname: Songca
authors.forename: Samuel O
authors.initials: SO
authors.lastname: Oluwafemi
authors.forename: Adebola O
authors.initials: AO
authors.lastname: Oyedeji
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000081008:Bicyclic Monoterpenes; D008297:Male; D039821:Monoterpenes / Q000737:chemistry; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010836:Phytol / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D010836:Phytol; C009951:verbenol
keywords: Acacia mearnsii; cis-verbenol; egg albumin-induced oedema; essential oils; inflammation; phytol