title: Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells.
abstract: The expression and function of the ATP-binding cassette (ABC) transporter ABCG2 have been studied for two decades in both adult and cancer stem cells. However, this important ABC transporter has not been well characterized in human embryonic stem cells (hESCs). Studies designed to understand the role of ABCG2 in hESCs are still in their initial stages. Several recent reports on expression patterns of theABCG2gene in hESCs contain contradictory results at both the mRNA and protein levels. In this review, we provide possible explanations for these discrepancies inABCG2expression patterns. We discuss micro-RNA-mediated regulatory roles in controlling ABCG2 mRNA stability and translation, which are associated with hESC pluripotency and differentiation.
authors.affiliation: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Raji
authors.initials: R
authors.lastname: Padmanabhan
authors.affiliation: NIH Stem Cell Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Chen
authors.affiliation: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Gottesman
keywords: ABCG2; ATP-binding cassette; Human embryonic stem cells; differentiation; pluripotency