title: Increased interleukin-23/17 axis and C-reactive protein are associated with severity of acute pancreatitis in patients.
abstract: OBJECTIVE
  The interleukin (IL)-23/IL-17 axis plays an important role in various inflammatory conditions but its function in acute pancreatitis (AP) is not well understood. The present study investigated the relationship between serum levels of IL-23, IL-17, and C-reactive protein (CRP) in patients and the severity of AP.
  
  
  METHODS
  Eighty-five patients with AP were categorized into mild group, moderately severe group, and severe group according to the revised Atlanta classification, 2012. Serum levels of IL-23 and IL-17 were measured by enzyme-linked immunosorbent assay in patients 48 hours after admission. The CRP levels of patients were also measured on admission and 48 hours after admission.
  
  
  RESULTS
  The serum levels of CRP of patients on admission and 48 hours after admission and levels of IL-23 and IL-17 of patients 48 hours after admission increased alone with the severity of AP, respectively (P < 0.01). The serum levels of IL-23 and IL-17 in the patients were correlated with CRP levels (r = 0.234, r = 0.552, P < 0.001, respectively).
  
  
  CONCLUSIONS
  The serum levels of IL-17, IL-23, and CRP are correlated with the severity of AP and represent valuable prognostic factors in the assessment of disease severity of patients with AP.
authors.affiliation: From the *Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai; †Department of Clinical Medicine, Soochow University School of Medicine, Suzhou, Jiangsu Province; and ‡Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Jia
authors.forename: Maochun
authors.initials: M
authors.lastname: Tang
authors.forename: Lei
authors.initials: L
authors.lastname: Qiu
authors.forename: Ruiqing
authors.initials: R
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Cheng
authors.forename: Xiuying
authors.initials: X
authors.lastname: Ma
authors.forename: Guojian
authors.initials: G
authors.lastname: Yin
authors.forename: Guoyong
authors.initials: G
authors.lastname: Hu
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000145:classification / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D020381:Interleukin-17; D053759:Interleukin-23; D002097:C-Reactive Protein