title: Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia.
abstract: Exercise-induced arterial hypoxemia (EIAH) is often found in endurance-trained subjects at high exercise intensity. The role of erythrocyte deformability (ED) in EIAH has been scarcely explored. We aimed to explore the role of erythrocyte properties and lactate accumulation in the response of ED in EIAH. ED was determined in 10 sedentary and in 16 trained subjects, both before and after a maximal incremental test, and after recovery, along with mean corpuscular volume (MCV) and red blood cell lactate concentrations. EIAH was found in 6 trained subjects (∆SaO2=-8.25±4.03%). Sedentary and non-EIAH trained subjects showed reduced ED after exercise, while no effect on ED was found in EIAH trained subjects. After exercise, lactate concentrations rose and MCV increased equally in all groups. ED is strongly driven by cell volume, but the different ED response to exercise in EIAH shows that other cellular mechanisms may be implicated. Interactions between membrane and cytoskeleton, which have been found to be O2-regulated, play a role in ED. The drop in SaO2 in EIAH subjects can improve ED response to exercise. This can be an adaptive mechanism that enhances muscular and pulmonary perfusion, and allows the achievement of high exercise intensity in EIAH despite lower O2 arterial transport.
authors.affiliation: Research Universitary Institute Dr. Viña Giner, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Alis
authors.affiliation: Research Universitary Institute Dr. Viña Giner, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Ferioli
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: La Torre
authors.affiliation: Research Universitary Institute Dr. Viña Giner, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Blesa
authors.affiliation: Research Universitary Institute Dr. Viña Giner, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Romagnoli
mesh_terms: D000328:Adult; D004907:Erythrocyte Deformability; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006452:Hemoglobinometry; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood
chemical_list: D019344:Lactic Acid; D010100:Oxygen