title: Protection of ginsenoside Rg1 on central nerve cell damage and the influence on neuron apoptosis.
abstract: This paper aimed to verify the function of ginsenoside in the repair of peripheral nerve injury through the model of sciatic nerve injury in rat. The method was to prepare the model of SD rat injury of sciatic nerve, and to conduct treatment with different dose of ginsenoside Rg1. At the same time, the control group was established. The regenerative repair, functional recovery and the situation of target organ, etc. were evaluated by neuromorphic metrology index, fluorescence gold retrograde tag, animal behavior index (sciatic nerve index). The result was the situation of nerve regenerative repair and functional recovery in high dose ginsenoside Rg1 group was obviously superior to other groups, the recovery of sciatic nerve index, target muscle, etc. were fine and mostly close to normal. It was concluded that ginsenoside Rg1 could effectively promote the regenerative repair of peripheral nerve injury, and accelerate the recovery of its nerve function. It could also promote the regeneration of peripheral nerve and the recovery of its nerve function.
authors.affiliation: Department of Neurosurgery, the People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Neurosurgery, the People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Bingzhou
authors.initials: B
authors.lastname: Cui
authors.affiliation: Department of Neurosurgery, the People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Haixin
authors.initials: H
authors.lastname: Lv
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D036145:Ginsenosides / Q000494:pharmacology*; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D059348:Peripheral Nerve Injuries / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D036145:Ginsenosides; D018696:Neuroprotective Agents; C035054:ginsenoside Rg1