title: Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage.
abstract: Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia-, hyperlipidemia-, hypertension- and inflammation-induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti-oxidants in diabetic cardiomyopathy based on our own works and literature information available.
authors.affiliation: Center of Cardiovascular Diseases at the First Hospital of the Jilin University Changchun, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Center of Cardiovascular Diseases at the First Hospital of the Jilin University Changchun, China ; Kosair Children's Hospital Research Institute, the Department of Pediatrics, the University of Louisville Louisville, KY, USA.
authors.forename: Shudong
authors.initials: S
authors.lastname: Wang
authors.affiliation: Kosair Children's Hospital Research Institute, the Department of Pediatrics, the University of Louisville Louisville, KY, USA ; Departments of Radiation Oncology, Pharmacology and Toxicology, the University of Louisville Louisville, KY, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
keywords: Anti-oxidants; Diabetic cardiomyopathy; Oxidative stress