title: Effect of obesity-related plasma hemodilution on serum tumor marker concentration in women.
abstract: OBJECTIVE
  We determined to investigate the effect of plasma hemodilution on tumor marker concentration in obese women.
  
  
  METHODS
  We collected the data for tumor markers (cancer-associated antigen 125 [CA125], carbohydrate antigen 19-9 [CA19-9], carcinoembryonic antigen [CEA] and α-fetoprotein) from 6917 healthy women who visited the health promotion center at the Chung-Ang University Hospital from 2003 to 2011. We used multivariate linear regression analysis and χ(2) -test for linear-by-linear association adjusting for age, alanine aminotransferase and creatinine to determine the association between the serum tumor marker concentrations, plasma volume, tumor marker mass, and body mass index (BMI).
  
  
  RESULTS
  Higher BMI was significantly associated with higher plasma volume (P < 0.001 for trend). The lower concentrations of CA125 and CA19-9 were significantly associated with increasing BMI (P < 0.001). Serum concentration and mass of CEA and α-fetoprotein were increased with higher BMI in obese women (P < 0.001). CEA in women had the opposite result to that in men due to visceral fat in women.
  
  
  CONCLUSIONS
  This study shows that we should consider the hemodilution effect in Asian obese women when interpreting serum tumor marker concentration in cancer screening.
authors.affiliation: Department of Obstetrics and Gynecology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Minyoung
authors.initials: M
authors.lastname: Park
authors.forename: In Ho
authors.initials: IH
authors.lastname: Chang
authors.forename: Hyun
authors.initials: H
authors.lastname: Kang
authors.forename: Seung Su
authors.initials: SS
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D010953:Plasma Volume / Q000502:physiology*; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D000509:alpha-Fetoproteins
keywords: alpha-fetoprotein; body mass index; cancer-associated antigen 125; carbohydrate antigen 19-9; carcinoembryonic antigen; hemodilution