title: Predictors of vertigo in patients with untreated vestibular schwannoma.
abstract: OBJECTIVE
  Previous studies have shown that vertigo is the most powerful negative predictor of quality of life in patients with vestibular schwannomas, but the variability in vertigo symptom severity is still poorly understood. We wanted to find out whether vertigo could be related to objective parameters such as tumor size, location, vestibular nerve function, hearing, and postural stability in patients with untreated vestibular schwannomas.
  
  
  METHODS
  Baseline data from prospective cohort study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Four hundred thirty-four consecutive patients with unilateral VS diagnosed on MRI. Mean age 56 years (range 16-84 yr). Fifty-three percent women.
  
  
  METHODS
  Diagnostic, with a medical history, otolaryngological examination, pure-tone and speech audiometry, MRI, posturography, and videonystagmography with bithermal caloric tests.
  
  
  METHODS
  Dizziness measured on a 100-mm visual analog scale (VAS). Secondary outcome measures were canal paresis and postural imbalance (static and dynamic posturography).
  
  
  RESULTS
  Three hundred three patients (70%) completed the VAS. Severe dizziness, defined as VAS 75 or greater, was reported by 9% of the patients. Larger tumors were associated with higher risk of postural instability and canal paresis. Moderate to severe dizziness was associated with postural imbalance and canal paresis, and possibly with small to medium-sized tumors. Postural instability was related to tumor size and canal paresis when measured by dynamic, but not with static, posturography.
  
  
  CONCLUSIONS
  A minority of VS patients experience severe vestibular symptoms related to canal paresis and postural instability. A curvilinear relationship is hypothesized between tumor size and dizziness.
authors.affiliation: *Departments of Otolaryngology Head and Neck Surgery and †Neurosurgery, Haukeland University Hospital, N-5021 Bergen, Norway; and ‡Department of Clinical Medicine, University of Bergen, N-5021 Bergen, Norway.
authors.forename: Jan Fredrik
authors.initials: JF
authors.lastname: Andersen
authors.forename: Kathrin Skorpa
authors.initials: KS
authors.lastname: Nilsen
authors.forename: Flemming Slinning
authors.initials: FS
authors.lastname: Vassbotn
authors.forename: Per
authors.initials: P
authors.lastname: Møller
authors.forename: Erling
authors.initials: E
authors.lastname: Myrseth
authors.forename: Morten
authors.initials: M
authors.lastname: Lund-Johansen
authors.forename: Frederik Kragerud
authors.initials: FK
authors.lastname: Goplen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002150:Caloric Tests; D015331:Cohort Studies; D004244:Dizziness / Q000453:epidemiology / Q000209:etiology; D007758:Ear, Inner / Q000503:physiopathology; D005260:Female; D006320:Hearing Tests; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D011446:Prospective Studies; D011788:Quality of Life; D012678:Sensation Disorders; D014717:Vertigo / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult