title: Immunohistochemical examination of effects of kefir, koumiss and commercial probiotic capsules on platelet derived growth factor-c and platelet derived growth factor receptor-alpha expression in mouse liver and kidney.
abstract: We investigated using immunohistochemistry the effects of kefir, koumiss and commercial probiotic capsules on the expression of platelet derived growth factor-c (PDGF-C) and platelet derived growth factor receptor-alpha (PDGFR-α) in mouse liver and kidney. Mice were assigned to four groups: group 1 was given commercial probiotic capsules, group 2 was given kefir, group 3 was given koumiss and group 4 was untreated. After oral administration for 15 days, body weights were recorded and liver and kidney tissue samples were obtained. Hematoxylin and eosin staining was used to examine histology. PDGF-C and PDGFR-α in liver and kidney were localized using the streptavidin-biotin peroxidase complex method (ABC). We found that the weights of the mice in the kefir, koumiss and commercial probiotic capsules groups increased compared to the control group. No differences in liver and kidney histology were observed in any of the experimental groups. Kefir, koumiss and the commercial probiotic preparation increased PDGF-C and PDGFR-α expression.
authors.affiliation: Health Services Vocational School, University of Namik Kemal , 59000, Tekirdag.
authors.forename: B
authors.initials: B
authors.lastname: Bakir
authors.forename: E K
authors.initials: EK
authors.lastname: Sari
authors.forename: B D
authors.initials: BD
authors.lastname: Aydin
authors.forename: S E
authors.initials: SE
authors.lastname: Yildiz
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002214:Capsules; D043302:Cultured Milk Products; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D019936:Probiotics / Q000494:pharmacology*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*
chemical_list: D002214:Capsules; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; C411423:platelet-derived growth factor C; D020796:Receptor, Platelet-Derived Growth Factor alpha
keywords: PDGF-C; PDGFR-α; kefir; kidney; koumiss; liver; probiotic