title: Heat-Irrigate Effect' of Radiofrequency Ablation on Relevant Regional Hepatocyte in Living Swine Liver-Initial Study on Pathology.
abstract: Radiofrequency ablation (RFA) is one of the effective methods for HCC treatment. However, because of the "heat-sink effect" (HSE), it is very difficult to achieve a complete ablation in intrahepatic tumors. This study establishes the animal model of RFA on living swine liver and observes the 'heat-irrigate effect' on relevant regional hepatocytes. Three liver segments of 6 Guangxi Bama mini-pigs were selected to be ablated closed to segmental outflow vessel under surveillance of sonography for 6 min, and pathological changes of relevant downstream region were observed. We observed an elliptic shape of ablated area with diameter of 2.2 ± 1.1 cm on gross liver. Thermal damage was seen in downstream regional of relevant portal vein under microscope. However, adjacent area around the vessel was remained intact. In conclusion, the 'heat-irrigate effect' in RFA could cause thermal damage along the downstream region of relevant portal vein and this influence decreased gradually toward the surface.
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. drjiangkai2013@163.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Jiye
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Liu
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Dong
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000758:Anesthesia; D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004195:Disease Models, Animal; D004566:Electrodes; D005260:Female; D022781:Hepatocytes / Q000473:pathology*; D006358:Hot Temperature; D007649:Ketamine / Q000008:administration & dosage; D008099:Liver / Q000473:pathology*; D008297:Male; D011169:Portal Vein / Q000473:pathology; D011846:Radio Waves; D013499:Surface Properties; D013552:Swine; D013556:Swine, Miniature; D013696:Temperature; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D007649:Ketamine
keywords: Heat-irrigate effect; Hepatocyte; Radiofrequency ablation (RFA); Thermal damage