title: Significant alleviation of Darier's disease with fractional CO2 laser.
abstract: Darier's disease (DD) is a dominantly inherited genodermatosis with highly variable expression. It is characterized by symmetrical hyperkeratotic papules affecting seborrheic areas and extremities. The existence of unsightly lesions could lead to discomfort and social handicap. Conventional treatment consists of topical and systemic steroids and/or retinoids alleviating DD. Ablative lasers also have been used to treat these conditions with variable results and side effects. To the best of our knowledge, fractional CO2 laser has never been used to treat DD. We present a case of a 36-year-old woman with verrucous and hyperkeratotic plaques of the forehead significantly improved after two sessions of fractional CO2 laser treatment. Neither scars nor pigmentary disorders were noted.
authors.affiliation: Dermatology Department, Habib Thameur Hospital, Laboratoire de recherche , Tunis , Tunisia.
authors.forename: Rym
authors.initials: R
authors.lastname: Benmously
authors.forename: Noureddine
authors.initials: N
authors.lastname: Litaiem
authors.forename: Houda
authors.initials: H
authors.lastname: Hammami
authors.forename: Talel
authors.initials: T
authors.lastname: Badri
authors.forename: Samy
authors.initials: S
authors.lastname: Fenniche
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D007644:Darier Disease / Q000532:radiotherapy*; D005260:Female; D005546:Forehead; D006801:Humans; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects / Q000295:instrumentation*
keywords: Darier's disease; Darier–White's disease; fractional CO2 laser; keratosis follicularis