title: Population based cohort study for pediatric infectious diseases research in Vietnam.
abstract: A population-based cohort study on pediatric infectious diseases was established at Khanh Hoa Province, central Vietnam in 2006, to determine the etiology and risk factors for severe pediatric infectious diseases (SPID) such as acute respiratory infection (ARI), diarrhea and dengue which are the major causes of under 5 mortality. A population census survey was conducted in Nha-Trang and Ninh-Hoa to collect demographic, social-behavioral data and disease burden on SPID. The study site covered a population of 353,525 residing in 75,826 households with 24,781 children less than 5 years. Hospital databases from two hospitals covering the region were obtained. Linking the census and hospital databases, we were able to investigate on a variety of SPID such as environmental tobacco smoking exposure and increased risked of pediatric pneumonia hospitalization, population density, water supply and risk of dengue fever and animal livestock and risk of hospitalized diarrhea. To determine incidence, viral etiology and risk factors for pediatric ARI/pneumonia, we setup a population based prospective hospitalized Pediatric ARI surveillance at Khanh Hoa General Hospital, Nha-Trang in February 2007. The study has revealed RSV, rhinovirus and influenza A as major viral pathogens, role of multiple viral infection and its interaction with bacteria in the development of pneumonia. In addition, we are also conducting a birth cohort study to investigate the incidence of congenital infection and its impact on physical-neurological development, and role of host genetic polymorphism on SPID hospitalization in Vietnam. Population mobility, high cost of regular census update and low mortality are the challenges.
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Lay-Myint
authors.initials: LM
authors.lastname: Yoshida
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: National Institute of Hygiene and Epidemiology , No 1, Yersin street, Hanoi, Vietnam.
authors.forename: Vu Dinh
authors.initials: VD
authors.lastname: Thiem
authors.affiliation: London School of Tropical Medicine and Hygiene , Keppel St, Bloomsbury, London WC1E 7HT, United Kingdom.
authors.forename: Wolf Peter
authors.initials: WP
authors.lastname: Smith
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Ataru
authors.initials: A
authors.lastname: Tsuzuki
authors.affiliation: National Institute of Hygiene and Epidemiology , No 1, Yersin street, Hanoi, Vietnam.
authors.forename: Vu Thi Thu
authors.initials: VT
authors.lastname: Huong
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Pediatrics, Nagasaki University Hospital, Graduate School of Biomedical Sciences, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Miyakawa
authors.affiliation: National Institute of Hygiene and Epidemiology , No 1, Yersin street, Hanoi, Vietnam.
authors.forename: Nguyen Thi Hien
authors.initials: NT
authors.lastname: Anh
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Kiwao
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Khanh Hoa General Hospital , 19 Yersin Street Nha Trang, Vietnam.
authors.forename: Nguyen Thu Thuy
authors.initials: NT
authors.lastname: Ai
authors.affiliation: KhanhHoa Provincial Public Health Service , 3A Han Thuyen Street, Nha Trang City, Khanh Hoa Province, Vietnam.
authors.forename: Le Huu
authors.initials: le H
authors.lastname: Tho
authors.affiliation: College of Pharmacy and Health Sciences, Wayne State University , 259 Mack Ave. Suite 2118, Detroit, MI 48201.
authors.forename: Paul
authors.initials: P
authors.lastname: Kilgore
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshino
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Toizumi
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
authors.affiliation: Department of Pediatrics, Nagasaki University Hospital, Graduate School of Biomedical Sciences, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Moriuchi
authors.affiliation: National Institute of Hygiene and Epidemiology , No 1, Yersin street, Hanoi, Vietnam.
authors.forename: Dang Duc
authors.initials: DD
authors.lastname: Anh
authors.affiliation: Institute of Tropical Medicine, Nagasaki University , 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Koya
authors.initials: K
authors.lastname: Ariyoshi
keywords: Population based cohort; Vietnam; infectious diseases; pediatric