title: [Influence of new thiazole and tetrazole derivatives on the antioxidant status of natural mouse populations having elevated 90Sr].
abstract: The studies on Apodemus (S.) uralensis captured on the control, not contaminated, territories and within the East Ural Radioactive Trace (EURT) area with soil pollution by 90Sr up to 16.7 MBq/m2 (451 Ci/km2), an average concentration of 90Sr up to 160 Bq/g of wet bone were performed. Thiazole or tetrazole derivatives, fluoroquinolone (antibacterial medication pefloxacin) were administered intraperitoneally or orally for ten days. The biochemical parameters of lipid peroxidation and antioxidant system in the peripheral blood plas- ma, erythrocytes, liver and spleen were studied. The effect of the preparations on the reduction of the con- centration of TBA-reactive substances (TBARS), the degree of osmotic hemolysis of cells, as well as the RNA/DNA ratio on the increase of the catalase activity, ceruloplasmin content was reflected. It characterizes the orientation on the normalization of the redox balance of homeostasis, the level of destructive processes in cells and tissues and the functional activity of the genome. It helps to increase the radioresistance and non- specific resistance of the organism under conditions of radioactive contamination of the environment.
authors.forename: L N
authors.initials: LN
authors.lastname: Rasina
authors.forename: V N
authors.initials: VN
authors.lastname: Charushin
authors.forename: S K
authors.initials: SK
authors.lastname: Kotovskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Orehova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D051189:Murinae; D012990:Soil Pollutants, Radioactive; D013326:Strontium Radioisotopes; D013777:Tetrazoles / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D012990:Soil Pollutants, Radioactive; D013326:Strontium Radioisotopes; D013777:Tetrazoles; D013844:Thiazoles; C045574:1H-tetrazole