title: Unusual presentation of Sjögren's syndrome.
abstract: We present a case of a 67-year-old woman admitted from the neurology clinic for further investigations of progressive ataxia and sensory symptoms. Neurological examination showed reduced pinprick and absent vibration sensations in the lower limbs. Motor system examination was normal. Her antinuclear antibodies titre was 1:100 with positive Ro antibodies. Her initial nerve conduction studies were normal. However, the lower limb somatosensory-evoked potentials (SSEP) demonstrated impairment of central sensory conduction pathway. Rheumatology review revealed a history of fatigue and Sicca symptoms and her Schirmer's test was strongly positive. This lead to the diagnosis of ganglionopathy associated to Sjögren's syndrome. She had an excellent response to intravenous methylprednisolone followed by oral prednisolone and intravenous cyclophosphamide infusions. This case highlights that dorsal column involvement can precede the diagnosis of primary Sjögren's syndrome.
authors.affiliation: King George Hospital, London, UK.
authors.forename: Aicha
authors.initials: A
authors.lastname: Bouraoui
authors.affiliation: Department of Rheumatology, Princess of Wales Hospital, Bridgend, UK.
authors.forename: Syed Farhan
authors.initials: SF
authors.lastname: Bari
authors.affiliation: Department of Rheumatology, University Hospital of Wales, Cardiff, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Nash
authors.affiliation: Department of Rheumatology, University Hospital of Wales, Cardiff, UK.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dawson
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D003937:Diagnosis, Differential; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D008775:Methylprednisolone