title: Mucosal vaccines: novel strategies and applications for the control of pathogens and tumors at mucosal sites.
abstract: The mucosal immune system displays several adaptations reflecting the exposure to the external environment. The efficient induction of mucosal immune responses also requires specific approaches, such as the use of appropriate administration routes and specific adjuvants and/or delivery systems. In contrast to vaccines delivered via parenteral routes, experimental, and clinical evidences demonstrated that mucosal vaccines can efficiently induce local immune responses to pathogens or tumors located at mucosal sites as well as systemic response. At least in part, such features can be explained by the compartmentalization of mucosal B and T cell populations that play important roles in the modulation of local immune responses. In the present review, we discuss molecular and cellular features of the mucosal immune system as well as novel immunization approaches that may lead to the development of innovative and efficient vaccines targeting pathogens and tumors at different mucosal sites.
authors.affiliation: a INSERM U970; Universite Paris Descartes; Sorbonne Paris-Cité; Paris, France.
authors.forename: Mevyn
authors.initials: M
authors.lastname: Nizard
authors.forename: Mariana O
authors.initials: MO
authors.lastname: Diniz
authors.forename: Helene
authors.initials: H
authors.lastname: Roussel
authors.forename: Thi
authors.initials: T
authors.lastname: Tran
authors.forename: Luis Cs
authors.initials: LC
authors.lastname: Ferreira
authors.forename: Cecile
authors.initials: C
authors.lastname: Badoual
authors.forename: Eric
authors.initials: E
authors.lastname: Tartour
mesh_terms: D058956:Administration, Mucosal; D000818:Animals; D006801:Humans; D018928:Immunity, Mucosal; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: cancer vaccines; homing molecules; immunization routes; mucosal adjuvants; mucosal imprinting; mucosal vaccines; resident memory T cells