title: Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control.
abstract: BACKGROUND
  Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult asthma.
  
  
  METHODS
  For this retrospective study, 154 patients with asthma aged 21-82 years were recruited from the allergy and pulmonary units of the Showa University Hospital. Data on longitudinal changes in IgE over the preceding 10 years were collected and logarithmically transformed. Associations between longitudinal change in IgE and clinical characteristics including asthma control test (ACT) score, asthma control, pulmonary function test, and antigen specific IgE, were assessed.
  
  
  RESULTS
  Patients with increased IgE tended to have significantly higher mean age, more episodes of acute exacerbation within a year, lower ACT scores, and used oral corticosteroids more frequently than those with decreased or unchanged IgE. The prevalence of uncontrolled asthma was higher in patients with increased IgE than in those with decreased or unchanged IgE. Mean %FEV1 and FEV1% were lower in patients with increased IgE than in those with decreased or unchanged IgE. Moreover, the prevalence of Aspergillus-specific IgE was higher in patients with increased IgE than in those with decreased or unchanged IgE.
  
  
  CONCLUSIONS
  These data suggest that a longitudinal increase in total IgE is associated with both poor asthma control and Aspergillus-specific IgE in patients with adult asthma.
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. tanakaa@med.showa-u.ac.jp.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. jinno@med.showa-u.ac.jp.
authors.forename: Megumi
authors.initials: M
authors.lastname: Jinno
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. medi123@infoseek.jp.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Hirai
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. ym820127@med.showa-u.ac.jp.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Miyata
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. philopon1004@yahoo.co.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Mizuma
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. munehiro1006@yahoo.co.jp.
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. shin04211978@yahoo.co.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Ohta
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. fzr02034@gmail.com.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. ymym0018@gmail.com.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. szshintr@yahoo.co.jp.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. takknyo@gmail.com.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yokoe
authors.affiliation: Department of Allergy, Sanno Hospital, Clinical Research Centers for Medicine, International University of Health and Welfare, Tokyo, Japan. adachim.iard@gmail.com.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Adachi
authors.affiliation: Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. sagarah@med.showa-u.ac.jp.
authors.forename: Hironori
authors.initials: H
authors.lastname: Sagara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001230:Aspergillus / Q000276:immunology; D001249:Asthma / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008168:Lung / Q000187:drug effects / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D018927:Anti-Asthmatic Agents; D015415:Biomarkers; D007073:Immunoglobulin E