title: Asymmetric dearomatization of β-naphthols through an amination reaction catalyzed by a chiral phosphoric acid.
abstract: A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized β-naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99% yield, up to 96% ee).
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/
authors.forename: Shou-Guo
authors.initials: SG
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yin
authors.forename: Chun-Xiang
authors.initials: CX
authors.lastname: Zhuo
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
keywords: amination reaction; asymmetric catalysis; dearomatization; naphthol; organocatalysis