title: Targeting endothelial progenitor cells in cancer as a novel biomarker and anti-angiogenic therapy.
abstract: Tumoral angiogenesis is mainly an endothelial cell-mediated process, which has been largely demonstrated to take on a crucial role in tumor growth, invasion, and metastasis. Thus, tumor-associated neovasculature represents a pivotal target in cancer therapy. Several mechanisms take part in the genesis of this pathological vasculature, most notably neoangiogenesis and postnatal vasculogenesis. These processes may also play a critical role in the resistance to antiangiogenic agents, leading to tumor progression. In particular, vasculogenesis is mediated by endothelial progenitor cells (EPCs), which include cellular subpopulations with different functional capacities. EPCs are able to proliferate, migrate, and differentiate into mature endothelial cells (ECs) in response to tumor growth, promoting the "angiogenic switch" and, consequently, inducing the invasion and metastases of cancer cells. Therefore, vasculogenesis mediated by EPCs represents an intriguing therapeutic target, both in early and late stages of cancer progression, thereby working as potential landmark for synthesizing novel and more effective anti-angiogenic drugs. Here, we aim to focus and to summarize several biological features of EPCs and EPC-based therapeutic approach with potential translation in human clinical trials.
authors.forename: Michele
authors.initials: M
authors.lastname: Ammendola
authors.forename: Christian
authors.initials: C
authors.lastname: Leporini
authors.forename: Maria
authors.initials: M
authors.lastname: Luposella
authors.forename: Rosario
authors.initials: R
authors.lastname: Sacco
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sammarco
authors.forename: Emilio
authors.initials: E
authors.lastname: Russo
authors.forename: Rosa
authors.initials: R
authors.lastname: Patruno
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
authors.forename: Girolamo
authors.initials: G
authors.lastname: Ranieri
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D014408:Biomarkers, Tumor / Q000502:physiology; D066026:Endothelial Progenitor Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D020533:Angiogenesis Inhibitors; D014408:Biomarkers, Tumor