title: Diagnostic and post-treatment CT appearance of biopsy proven mixed Cryptococcus and Candida cholangitis.
abstract: Cryptococcus neoformans and Candida are common opportunistic pathogens of human. There is very limited literature on Cryptococcus neoformans cholangitis or Candida cholangitis in immunocompetent patient while mixed Cryptococcus neoformans and Candida cholangitis has not been reported in the literature ever before. We hereby report the imaging findings of a case of mixed Cryptococcus neoformans and Candida cholangitis in an immunocompetent boy. The CT features included nodules in the cystic duct and common bile duct, dilatation of the intra- and extrahepatic bile ducts with mural thickening, irregular hypodense mass-like lesion extending along the bile ducts from the liver hilum to the periphery which was confirmed by the presence of enlarged and confluent lymph nodes. CT characteristics can contribute to timely diagnosis and treatment of this disease.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Yanji
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Radiology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Zhongshan, Guangdong, China.
authors.forename: Min-Yi
authors.initials: MY
authors.lastname: Cui
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liao
authors.affiliation: Department of Diagnostic Imaging, Sault Area Hospital, Sault Ste Marie, ON, Canada.
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Pui
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Xue-Hua
authors.initials: XH
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Can-Hui
authors.initials: CH
authors.lastname: Sun
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Zhen-Peng
authors.initials: ZP
authors.lastname: Peng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Zi-Ping
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Shi-Ting
authors.initials: ST
authors.lastname: Feng
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D002675:Child, Preschool; D002761:Cholangitis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D060085:Coinfection / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000935:Antifungal Agents
keywords: Bile duct; candida; computed tomography; cryptococcus; fungal infection