title: Intraocular Ossification in the GSP/pe Chicken With Imperfect Albinism.
abstract: The eyes of 2 male and 2 female GSP/pe chickens, the imperfect albino strain, were investigated at 52 weeks of age. Aged chickens of the GSP/pe colony became blind with bilateral ocular enlargement and opaque lenses. Affected eyes (bilateral in 2 males and unilateral in 2 females) were hard and difficult to section; histologic specimens were processed after decalcification. A large portion of the posterior chamber was occupied by cancellous bone containing fibrous and cartilaginous foci. Osseous tissues developed adjacent to the choroid, and no retinal pigment epithelium (RPE) was detected between osseous tissues and the choroid. Small segments of degenerate neuronal retina were scattered in the osseous tissue. The irises and ciliary bodies were deformed by osseous tissue, and the lenses had severe cataracts. These observations suggest that the intraocular osseous tissue may be derived from RPE in the hereditary incomplete-albino strain of chickens.
authors.affiliation: Research and Development Department, Nippon Institute for Biological Science, Ome, Tokyo, Japan k_shibuya@nibs.or.jp.
authors.forename: K
authors.initials: K
authors.lastname: Shibuya
authors.affiliation: Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.affiliation: Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mizutani
authors.affiliation: Research and Development Department, Nippon Institute for Biological Science, Ome, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Oshima
authors.affiliation: Research and Development Department, Nippon Institute for Biological Science, Ome, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamashita
authors.affiliation: Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
mesh_terms: D000417:Albinism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D002829:Choroid / Q000473:pathology; D015862:Choroid Diseases / Q000473:pathology / Q000662:veterinary*; D005128:Eye Diseases / Q000473:pathology / Q000662:veterinary*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010012:Osteogenesis; D011201:Poultry Diseases / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology
keywords: chicken; eyeball; hereditary disease; ossification; retinal pigment epithelium