title: Echocardiographic abnormalities in new-onset polymyositis/dermatomyositis.
abstract: OBJECTIVE
  To identify early echocardiographic abnormalities at the time of diagnosis of polymyositis (PM) and dermatomyositis (DM) and follow the echocardiographic findings during the first 3 months of therapy.
  
  
  METHODS
  We included 30 PM/DM patients (23/7) with a mean age of 42.3 ± 1.6 years and without cardiovascular symptoms. Age-matched healthy patients served as controls. Clinical characteristics were recorded. Traditional echocardiography and tissue Doppler imaging (TDI) were performed to measure systolic [ejection fraction, right ventricular fractional area change (RV FAC), lateral and tricuspid annulus s velocities] and diastolic echocardiographic variables (mitral inflow velocities: E, A; deceleration time: DT; lateral and tricuspid annulus e', a' velocities, lateral E/e').
  
  
  RESULTS
  The left and right ventricular systolic dysfunction detected by TDI at the time of the PM/DM diagnosis improved, and characteristic values at the end of the followup period were comparable to those of the controls (lateral s: 10.6 ± 0.2, 8.7 ± 0.4, 9.6 ± 0.3, 11.3 ± 0.2 cm/s; RV FAC: 45.2 ± 2.3, 36.9 ± 1.5, 42.2 ± 1.3, 46.9 ± 1.2%; tricuspid s: 13.3 ± 0.2, 9.5 ± 0.4, 10.3 ± 0.3, 11.6 ± 0.5 cm/s; control, 0, 1, and 3 mos, respectively). Measurements indicated the development of diastolic dysfunction at 3 mos (E/A: 1.4 ± 0.1, 1.29 ± 0.05, 1.03 ± 0.05, 0.92 ± 0.05; DT: 148.6 ± 3.6, 157.3 ± 5.7, 168.3 ± 6.0, 184.3 ± 6.2 ms; lateral e': 12.8 ± 0.3, 12.1 ± 0.5, 10.2 ± 0.6, 10.8 ± 0.8 cm/s; E/e': 5.6 ± 0.1, 5.0 ± 0.22, 6.92 ± 0.46, 7.64 ± 0.47; control, 0, 1, and 3 mos, respectively).
  
  
  CONCLUSIONS
  TDI is a useful method to detect early cardiac abnormalities complementing the conventional echocardiographic measurements. LV and RV systolic dysfunction found in the acute phase significantly improved during the first 3 months of therapy; however, deterioration of diastolic dysfunction was also observed.
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen. doktorpandi@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Péter
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Balogh
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Szilágyi
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: Réka
authors.initials: R
authors.lastname: Faludi
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nagy-Vincze
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: István
authors.initials: I
authors.lastname: Édes
authors.affiliation: From the Institute of Cardiology, and the Institute of Internal Medicine, University of Debrecen, Debrecen; Heart Institute, University of Pécs, Pécs, Hungary; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.A. Péter, MD; Á. Balogh, MD, PhD, Institute of Cardiology, University of Debrecen; S. Szilágyi, MD, PhD, Cardiothoracic Centre, Freeman Hospital; R. Faludi, MD, PhD, Heart Institute, University of Pécs; M. Nagy-Vincze, MD, Institute of Internal Medicine, University of Debrecen; I. Édes, MD, PhD, DSc, Institute of Cardiology, University of Debrecen; K. Dankó, MD, PhD, DSc, Institute of Internal Medicine, University of Debrecen.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
mesh_terms: D000328:Adult; D003882:Dermatomyositis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D014261:Tricuspid Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018754:Ventricular Dysfunction / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: DERMATOMYOSITIS; ECHOCARDIOGRAPHY; POLYMYOSITIS; SYSTOLIC AND DIASTOLIC DYSFUNCTION; TISSUE DOPPLER IMAGING