title: Efficacy and tolerability of anticholinergics in Korean children with overactive bladder: a multicenter retrospective study.
abstract: We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age 7.3±2.6 yr) who were diagnosed with OAB from 2008 to 2011 were retrospectively reviewed. The mean duration of OAB symptoms before anticholinergic treatment was 16.9±19.0 months. The mean duration of medication was 5.6±7.3 months. Urgency urinary incontinence episodes per week decreased from 1.9±3.1 to 0.4±1.5 times (P<0.001). The median voiding frequency during daytime was decreased from 9.2±5.4 to 6.3±4.2 times (P<0.001). According to 3-day voiding diaries, the maximum and average bladder capacity were increased from 145.5±66.9 to 196.8±80.3 mL and from 80.8±39.6 to 121.8±56.5 mL, respectively (P<0.001). On uroflowmetry, maximum flow rate was increased from 17.6±8.4 to 20.5±8.2 mL/sec (P<0.001). Adverse effects were reported in 14 (4.3%) children and six children (1.8%) discontinued medication due to adverse effects. Our results indicate that anticholinergics are effective to improve OAB symptoms and tolerability was acceptable without severe complications in children.
authors.affiliation: Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Se Jin
authors.identifier: 0000-0002-7650-5393
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ki Soo
authors.identifier: 0000-0003-0373-4336
authors.initials: KS
authors.lastname: Pai
authors.affiliation: Department of Urology, Soonchunhyang University Hospital, College of Medicine, Soonchunhyang University, Bucheon, Korea.
authors.forename: Jun Mo
authors.identifier: 0000-0003-4978-1867
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kwanjin
authors.identifier: 0000-0002-8926-3047
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kun Suk
authors.identifier: 0000-0001-8982-6922
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sang Hoon
authors.identifier: 0000-0003-4888-483X
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Sungchan
authors.identifier: 0000-0002-2337-983X
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sun-Ouck
authors.identifier: 0000-0002-5832-8303
authors.initials: SO
authors.lastname: Kim
authors.affiliation: Department of Urology, Sungkyunkwan University School of Medicine, Samsung Changwon Hospital, Chnagwon, Korea.
authors.forename: Dong Soo
authors.identifier: 0000-0002-7557-0820
authors.initials: DS
authors.lastname: Ryu
authors.affiliation: Department of Urology, Sunkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors.forename: Minki
authors.identifier: 0000-0002-3735-9290
authors.initials: M
authors.lastname: Baek
authors.affiliation: Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Sang Don
authors.identifier: 0000-0001-9459-3887
authors.initials: SD
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
authors.forename: Jung Won
authors.identifier: 0000-0003-1846-3153
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young Jae
authors.identifier: 0000-0002-3225-916X
authors.initials: YJ
authors.lastname: Im
authors.affiliation: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Won
authors.identifier: 0000-0003-0941-1300
authors.initials: SW
authors.lastname: Han
authors.affiliation: Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Jae Min
authors.identifier: 0000-0003-3593-9643
authors.initials: JM
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Min Hyun
authors.identifier: 0000-0002-7965-7587
authors.initials: MH
authors.lastname: Cho
authors.affiliation: Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.
authors.forename: Tae-Sun
authors.identifier: 0000-0002-1249-9342
authors.initials: TS
authors.lastname: Ha
authors.affiliation: Department of Urology, Dong-A University, Busan, Korea.
authors.forename: Won Yeol
authors.identifier: 0000-0001-6640-7872
authors.initials: WY
authors.lastname: Cho
authors.affiliation: Department of Urology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors.forename: Hong Jin
authors.identifier: 0000-0002-8647-1668
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D002648:Child; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D003248:Constipation / Q000209:etiology; D004244:Dizziness / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D018680:Cholinergic Antagonists
keywords: Anticholinergics; Efficacy; Overactive Urinary Bladder; Tolerability; Urinary Incontinence