title: What is the next generation therapeutic strategy for castration-resistant prostate cancer.
abstract: Prostate cancer (PCa) is one of the most common cancers in the world. Since androgen receptor (AR) signal plays key roles in the PCa progression, targeting androgens via the current androgen deprivation therapy (ADT) is the main therapeutic strategy for advanced PCa. However, most patients who receive ADT, including the second generation anti-androgens enzalutamide (also known as MDV3100) may finally develop the castration (or anti-androgen) resistance after 12-24 months treatment. In the manuscript by Asangani et al., the authors demonstrated that targeting the amino-terminal bromodomains of BRD4 could preferentially suppress human castration-resistant prostate cancer (CRPC) cell lines. While further studies are required to understand the full impact of their findings, the innovative approach provides a potential novel epigenetic approach for the concerted blockade of oncogenic drivers in CRPC.
authors.forename: Si-Meng
authors.initials: SM
authors.lastname: Wen
authors.forename: Chang-Yi
authors.initials: CY
authors.lastname: Quan
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.forename: Zhi-Qun
authors.initials: ZQ
authors.lastname: Shang
authors.affiliation: Department of Urology, Second Hospital of Tianjin Medical University; Chawnshang Chang Sex Hormone Research Center, Tianjin Institute of Urology, Tianjin Medical University, Tianjin, China.
authors.forename: Yuan-Jie
authors.initials: YJ
authors.lastname: Niu
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000737:chemistry*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D014157:Transcription Factors / Q000737:chemistry*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D001381:Azepines; D009687:Nuclear Proteins; D014157:Transcription Factors; D014230:Triazoles