title: Invited review: Stem cells and muscle diseases: advances in cell therapy strategies.
abstract: Despite considerable progress to increase our understanding of muscle genetics, pathophysiology, molecular and cellular partners involved in muscular dystrophies and muscle ageing, there is still a crucial need for effective treatments to counteract muscle degeneration and muscle wasting in such conditions. This review focuses on cell-based therapy for muscle diseases. We give an overview of the different parameters that have to be taken into account in such a therapeutic strategy, including the influence of muscle ageing, cell proliferation and migration capacities, as well as the translation of preclinical results in rodent into human clinical approaches. We describe recent advances in different types of human myogenic stem cells, with a particular emphasis on myoblasts but also on other candidate cells described so far [CD133+ cells, aldehyde dehydrogenase-positive cells (ALDH+), muscle-derived stem cells (MuStem), embryonic stem cells (ES) and induced pluripotent stem cells (iPS)]. Finally, we provide an update of ongoing clinical trials using cell therapy strategies.
authors.affiliation: Institut de Myologie, CNRS FRE3617, UPMC Univ Paris 06, UM76, INSERM U974, Sorbonne Universités, 47 bd de l'Hôpital, Paris, 75013, France.
authors.forename: Elisa
authors.initials: E
authors.lastname: Negroni
authors.forename: Teresa
authors.initials: T
authors.lastname: Gidaro
authors.forename: Anne
authors.initials: A
authors.lastname: Bigot
authors.forename: Gillian S
authors.initials: GS
authors.lastname: Butler-Browne
authors.forename: Vincent
authors.initials: V
authors.lastname: Mouly
authors.forename: Capucine
authors.initials: C
authors.lastname: Trollet
mesh_terms: D064987:Cell- and Tissue-Based Therapy / Q000379:methods* / Q000639:trends*; D006801:Humans; D009135:Muscular Diseases / Q000628:therapy*; D013234:Stem Cells
keywords: cell therapy; muscle ageing; muscular dystrophy; myoblast; satellite cells; transplantation