title: Glutathione S-transferase M1 (GSTM1) null genotype and coronary artery disease risk: a meta-analysis.
abstract: BACKGROUND
  The Glutathione S-Transferase M1 (GSTM1) null genotype has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted.
  
  
  METHODS
  Databases including PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Twenty-six studies with 10595 cases and 13782 controls were included in this meta-analysis. The association between GSTM1 null genotype and CAD risk was significant (OR = 1.35; 95% CI, 1.09 - 1.67; P < 0.01). When stratified by ethnicity, the significantly elevated risk were observed in Caucasians (OR = 1.39; 95% CI, 1.07 - 1.81; P = 0.01) but not in Asians (OR = 1.27; 95% CI, 0.87 - 1.86; P = 0.22). No significantly increased myocardial infarction risk was observed (OR = 0.96; 95% CI, 0.78 - 1.18; P = 0.68). Subgroup analysis on the smoking status showed that the increased risk was found in smokers (OR = 1.66; 95% CI, 1.14 - 2.42; P < 0.01) but not in non-smokers (OR = 1.30; 95% CI, 1.74 - 2.28; P = 0.37).
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis suggested that GSTM1 null genotype was a risk factor for CAD, especially in Caucasians and smokers.
authors.affiliation: Department of Traditional Chinese Medcine, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medcine Shanghai 200437, China.
authors.forename: Zhen-Xian
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Department of Traditional Chinese Medcine, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medcine Shanghai 200437, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
keywords: Coronary artery disease; GSTM1; genetic; meta-analysis