title: Plasma and Intracellular Antiretroviral Concentrations in HIV-Infected Patients under Short Cycles of Antiretroviral Therapy.
abstract: Study of plasma and intracellular concentrations of atazanavir, lopinavir, nevirapine, and efavirenz was conducted on 48 patients under short cycles of antiretroviral therapy. Intracellular concentrations (IC) were still measurable for all drugs after 85 h or 110 h drug intake despite the absence of drug in plasma for atazanavir and lopinavir. A linear relationship between plasma and intracellular efavirenz was observed. Further studies to fully understand the impact of IC in the intermittent antiviral treatment are required.
authors.affiliation: Institut de Chimie de Nice UMR 7272, Université Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Zehnacker
authors.affiliation: Laboratory of Pharmacology-Toxicology, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.
authors.forename: Emuri
authors.initials: E
authors.lastname: Abe
authors.affiliation: Immunology and Virology Unit, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Mathez
authors.affiliation: Laboratory of Pharmacology-Toxicology, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Alvarez
authors.affiliation: Immunology and Virology Unit, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Leibowitch
authors.affiliation: Institut de Chimie de Nice UMR 7272, Université Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Azoulay