title: Elevation of circulating LOX-1 ligand levels in Zucker obese and diabetic rats.
abstract: LOX-1 ligands containing apolipoprotein B (LAB) reflect ligand activity of LOX-1, which is a key molecule for initiation of atherosclerosis. The Zucker rat is a well-known model used for research on obesity and diabetes. Blood levels of LAB were compared among Zucker fatty (ZF), Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. Log-transformed LAB was significantly higher in ZF and ZDF rats than in control ZL rats, while no significant difference was found in log-transformed LAB of ZF and ZDF rats. This study for the first time demonstrated that circulating LOX-1 ligands were elevated in obesity and diabetes model rats.
authors.affiliation: Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. Electronic address: wakabaya@hyo-med.ac.jp.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Wakabayashi
authors.affiliation: Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shimomura
authors.affiliation: Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nakanishi
authors.affiliation: Biomarker Science, Kyoto 606-8225, Japan.
authors.forename: Kagehiro
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D006442:Glycated Hemoglobin / Q000378:metabolism*; D007333:Insulin Resistance; D008024:Ligands; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D051381:Rats; D011924:Rats, Zucker; D051127:Scavenger Receptors, Class E / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008024:Ligands; D051127:Scavenger Receptors, Class E; C495136:OLR1 protein, rat
keywords: Diabetes mellitus; LOX-1; Obesity; Oxidative stress; Zucker rats