title: A new isoquinoline alkaloid with anti-microbial properties from Berberis jaeschkeana Schneid. var. jaeschkeana.
abstract: One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), β-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fractions of Berberis jaeschkeana Schneid var. jaeschkeana. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.
authors.affiliation: a Institute of Chemical Sciences , University of Swat , Swat 19130 , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Alamzeb
authors.forename: M Rafiullah
authors.initials: MR
authors.lastname: Khan
authors.lastname: Mamoon-Ur-Rashid
authors.forename: Saqib
authors.initials: S
authors.lastname: Ali
authors.forename: Ashfaq Ahmad
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D028142:Berberis / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D007546:Isoquinolines; C000598301:berberidione; C039109:isoquinoline
keywords: Berberis jaeschkeana; anti-microbial; berberidione