title: 'Click chemistry' for diagnosis: a patent review on exploitation of its emerging trends.
abstract: BACKGROUND
  Click chemistry is the novel synthetic approach towards developing reactions with large thermodynamic driving forces to give almost complete conversion of new molecular reagents to a single product. Thus, click chemistry describes the chemistry for making carbon-heteroatom-carbon bonds in benign solvents, especially in water, and having a plethora of chemical and biological applications. This has played an important role in early detection of diseases, real-time monitoring of drug delivery and investigating the biomolecular functions in vivo.
  
  
  METHODS
  This review aims at highlighting the research advancements in click chemistry published in the patent literature and categorizing the patents according to the technological progress. An extensive search was carried out to collect and analyze the patent information claiming the use of click chemistry in biotechnology, especially for diagnosis. The study further concentrates on licensing of the click chemistry patents and defining the recent breakthroughs. Different databases like Espacenet, ISI Web of Science, Patbase and Thomson Innovation are used to compile the relevant literature.
  
  
  CONCLUSIONS
  In recent years, considerable development in the click concept has encouraged researchers in using click reactions in almost every branch of industry that uses chemistry. Click chemistry for chemical ligation has been immensely explored in the field of biotechnology especially for detection, diagnosis and therapeutics.
authors.affiliation: CSIR Unit for Research and Development of Information Products , "Jopasana", 85/1, Paud Road, Kothrud, Pune 411 038 , India +91 9850982558 ; +91 20 25383558 ; anita@urdip.res.in.
authors.forename: Anita
authors.initials: A
authors.lastname: Mandhare
authors.forename: Paromita
authors.initials: P
authors.lastname: Banerjee
authors.forename: Smita
authors.initials: S
authors.lastname: Bhutkar
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Hirwani
mesh_terms: D057930:Click Chemistry; D006801:Humans; D008004:Licensure; D057054:Molecular Imaging; D010330:Patents as Topic; D011933:Reagent Kits, Diagnostic
chemical_list: D011933:Reagent Kits, Diagnostic
keywords: Huisgen reaction; click chemistry; detection; diagnosis; molecular imaging; radio-labeling