title: Genetic variation meets replication origins.
abstract: Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Hause
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: shendure@uw.edu.
authors.forename: Jay
authors.initials: J
authors.lastname: Shendure
mesh_terms: D006801:Humans; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci