title: Voltage sensor gating charge transfer in a hERG potassium channel model.
abstract: Relaxation of a hERG K(+) channel model during molecular-dynamics simulation in a hydrated POPC bilayer was accompanied by transitions of an arginine gating charge across a charge transfer center in two voltage sensor domains. Inspection of the passage of arginine side chains across the charge transfer center suggests that the unique hydration properties of the arginine guanidine cation facilitates charge transfer during voltage sensor responses to changes in membrane potential, and underlies the preference of Arg over Lys as a mobile charge carrier in voltage-sensitive ion channels.
authors.affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom.
authors.forename: Charlotte K
authors.initials: CK
authors.lastname: Colenso
authors.affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Sessions
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: Jules C
authors.initials: JC
authors.lastname: Hancox
authors.affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom. Electronic address: c.dempsey@bristol.ac.uk.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Dempsey
mesh_terms: D000595:Amino Acid Sequence; D004579:Electron Transport; D051638:Ether-A-Go-Go Potassium Channels / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data; D010713:Phosphatidylcholines / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; C028694:1-palmitoyl-2-oleoylphosphatidylcholine