title: Effect of a 1-Year Obesity Intervention (KLAKS Program) on Preexisting Autonomic Nervous Dysfunction in Childhood Obesity.
abstract: Childhood obesity may involve autonomic nervous system dysfunction. Whether it improves following weight loss remains unclear. Thirty-one obese children (body mass index standard deviation scores 2.33 ± 0.47; age 11.2 ± 2.0) completed a 1-year lifestyle intervention (KLAKS: Concept Leipzig: Adiposity Therapy for School-Aged Children). Anthropometric/biochemical parameters and autonomic nervous system function (heart rate variability, quantitative pupillography) were assessed at baseline and follow-up. A multivariate model for changes in body mass index standard deviation scores considered age, gender, and changes in autonomic nervous system function. Weight status (Δ body mass index standard deviation scores: 0.16 [0.05, 0.29], P = .008), glycemic control, and free fatty acids (all P < .05) improved after the intervention. Redilation velocity increased by 0.22 mm/s [0.06, 0.38] (P = .008), and changes tended to be negatively associated with Δ body mass index standard deviation scores (P = .08 [-0.61, 0.03]). Relative reflex amplitude (23.4 vs 26.3, P = .004) and constriction velocity (4.97 mm/s vs 5.47 mm/s, P < .001) also improved. Our data provide preliminary evidence that lifestyle-intervention induced improvement of weight status/metabolic risk factors may ameliorate some parameters of autonomic nervous system dysfunction in childhood obesity.
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Germany susann.blueher@medizin.uni-leipzig.de.
authors.forename: Susann
authors.initials: S
authors.lastname: Blüher
authors.affiliation: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Germany Clinical Trial Centre, University of Leipzig, Leipzig, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Petroff
authors.affiliation: Pediatric Medical Center, Leipzig, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Keller
authors.affiliation: KLAKS e.V., Leipzig, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Wagner
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Joseph
authors.initials: J
authors.lastname: Classen
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Baum
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001342:Autonomic Nervous System Diseases / Q000209:etiology* / Q000628:therapy*; D001786:Blood Glucose; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008019:Life Style; D008074:Lipoproteins / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D009460:Neurologic Examination; D063766:Pediatric Obesity / Q000150:complications* / Q000523:psychology / Q000534:rehabilitation*
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D008074:Lipoproteins
keywords: KLAKS program; autonomic nervous dysfunction; childhood; obesity; weight loss