title: A deeper look into translation initiation.
abstract: Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates.
authors.affiliation: RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: andrei.korostelev@umassmed.edu.
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Korostelev
mesh_terms: D000818:Animals; D015977:Eukaryotic Initiation Factor-1 / Q000737:chemistry*; D039621:Eukaryotic Initiation Factor-3 / Q000737:chemistry*; D039642:Eukaryotic Initiation Factors / Q000378:metabolism*; D006801:Humans; D007716:Kluyveromyces / Q000378:metabolism*; D010442:Peptide Chain Initiation, Translational; D054682:Ribosome Subunits, Small, Eukaryotic / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry*
chemical_list: D015977:Eukaryotic Initiation Factor-1; D039621:Eukaryotic Initiation Factor-3; D039642:Eukaryotic Initiation Factors; D029701:Saccharomyces cerevisiae Proteins