title: A large-scale cross-sectional study of ALK rearrangements and EGFR mutations in non-small-cell lung cancer in Chinese Han population.
abstract: The predictive power of age at diagnosis and smoking history for ALK rearrangements and EGFR mutations in non-small-cell lung cancer (NSCLC) remains not fully understood. In this cross-sectional study, 1160 NSCLC patients were prospectively enrolled and genotyped for EML4-ALK rearrangements and EGFR mutations. Multivariate logistic regression analysis was performed to explore the association between clinicopathological features and these two genetic aberrations. Receiver operating characteristic (ROC) curves methodology was applied to evaluate the predictive value. We showed that younger age at diagnosis was the only independent variable associated with EML4-ALK rearrangements (odds ratio (OR) per 5 years' increment, 0.68; p < 0.001), while lower tobacco exposure (OR per 5 pack-years' increment, 0.88; p < 0.001), adenocarcinoma (OR, 6.61; p < 0.001), and moderate to high differentiation (OR, 2.05; p < 0.001) were independently associated with EGFR mutations. Age at diagnosis was a very strong predictor of ALK rearrangements but poorly predicted EGFR mutations, while smoking pack-years may predict the presence of EGFR mutations and ALK rearrangements but with rather limited power. These findings should assist clinicians in assessing the likelihood of EML4-ALK rearrangements and EGFR mutations and understanding their biological implications in NSCLC.
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Hong
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Fang
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Zhihuang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yan
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Qin
authors.affiliation: Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Tang
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Ma
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Xue
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases