title: Interception of cobalt-based carbene radicals with α-aminoalkyl radicals: a tandem reaction for the construction of β-ester-γ-amino ketones.
abstract: The interception of cobalt-based carbene radicals with α-aminoalkyl radicals was combined with the Kornblum-DeLaMare reaction and provides β-ester-γ-amino ketones, which are otherwise difficult to obtain in high chemoselectivity. Mechanistically, this transformation is an interplay of cobalt-based carbene radicals, organoradicals, and ionic intermediates and involves the construction of two C-C bonds and one C=O bond in a one-pot process. The reaction also features a wide substrate scope and is highly efficient and insensitive to moisture and air.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China).
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiewen
authors.initials: J
authors.lastname: Jiang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Luo
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Wang
authors.forename: Jijun
authors.initials: J
authors.lastname: Chen
authors.forename: Huihuang
authors.initials: H
authors.lastname: Li
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
keywords: Kornblum-DeLaMare reaction; carbene radicals; cobalt; radical reactions; tandem reactions