title: Development of a Concise Synthetic Approach to Access Oroxin A.
abstract: A novel environment-friendly method to access bioactive oroxin A through a one-pot/two-step process from naturally abundant and inexpensive baicalin is described. The procedure presented here has several advantages including clean, one-pot, synthetic ease, and large-scale feasibility. This work also provides a model strategy for rapid and diverse access to natural molecules sharing the common skeleton of this family.
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen). ; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States, Fax: +1 (409) 772-9648; Tel: +1 (409) 772-9748; jizhou@utmb.edu (J. Zhou).
authors.forename: Haijun
authors.initials: H
authors.lastname: Chen
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Guihua
authors.initials: G
authors.lastname: He
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Cailong
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Longrong
authors.initials: L
authors.lastname: Dong
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Xie
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Jianlei
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234; chenhaij@gmail.com (H. Chen).
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States, ; Tel: +1 (409) 772-9748; jizhou@utmb.edu (J. Zhou).
authors.forename: Jia
authors.initials: J
authors.lastname: Zhou