title: Hybrid ruthenium ROMP catalysts based on an engineered variant of β-barrel protein FhuA ΔCVF(tev) : effect of spacer length.
abstract: A biohybrid ring-opening olefin metathesis polymerization catalyst based on the reengineered β-barrel protein FhuA ΔCVF(tev) was chemically modified with respect to the covalently anchored Grubbs-Hoveyda type catalyst. Shortening of the spacer (1,3-propanediyl to methylene) between the N-heterocyclic carbene ligand and the cysteine site 545 increased the ROMP activity toward a water-soluble 7-oxanorbornene derivative. The cis/trans ratio of the double bond in the polymer was influenced by the hybrid catalyst.
authors.affiliation: Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52056 Aachen (Germany).
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Sauer
authors.forename: Marco
authors.initials: M
authors.lastname: Bocola
authors.forename: Claudio
authors.initials: C
authors.lastname: Broglia
authors.forename: Marcus
authors.initials: M
authors.lastname: Arlt
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Zhu
authors.forename: Melanie
authors.initials: M
authors.lastname: Brocker
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schwaneberg
authors.forename: Jun
authors.initials: J
authors.lastname: Okuda
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003545:Cysteine / Q000737:chemistry; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000737:chemistry; D007536:Isomerism; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D058105:Polymerization; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C050900:FhuA protein, E coli; D006571:Heterocyclic Compounds; C030011:carbene; D012428:Ruthenium; D003545:Cysteine; D008697:Methane
keywords: biohybrid catalysis; chemogenetic approach; metalloenzymes; ring-opening polymerization; ruthenium