title: [Effects of repeated short-term immobilization stress on plastisity of brain cortical division and cognition in adult rats with normal and disturbed embryogenesis].
abstract: The aim of the work was the analysis of the changes in a number of labile synaptopodin-positi- ve dendritic spines in parietal cortex and the CA1 field of the hippocampus, which characterize plasticity of intracellular interaction, and of the memorization after short-term repeated immobili- zation stress (daily for 5 minutes, 10 days), both in control rats and in rats subjected to prenatal hypoxia (E14, 7% of O2, 3 hours). There were observed deterioration of short-term and long-term memory, decrease in number labile spines in the CA1 field of the hippocampus (for 17.3 ± 10.4%; p ≤ 0.05) and their increase in a molecular layer of brain parietal cortex (for 36.9 ± 9.2%) at the adult rats with normal embryogenesis after immobilization stress in comparison with control intact animals. At the rats subjected to a prenatal hypoxia, regardless of that, they were ex- posed to an immobilized stress at an adult stage or not, was noted both violation of short-term and long-term memory, and decrease in number labile spines in the CA1 field of the hippocampus (for 22.9 ± 10.5%) and parietal cortex (for 28.1 ± 9.3%). The obtained data allow to conclude that the increase of plasticity providing adaptive behavior of animals, takes place in neocortical neuronal networks as a reply to a short-term repeating stress only at normal brain formation during embryo- genesis, while, violation of embryogenesis leads to decrease in plasticity and adaptive opportuni- ties of the nervous system during further ontogenesis.
authors.forename: D S
authors.initials: DS
authors.lastname: Vasil'ev
authors.forename: N M
authors.initials: NM
authors.lastname: Dubrovskaia
authors.forename: N L
authors.initials: NL
authors.lastname: Tumanova
authors.forename: I A
authors.initials: IA
authors.lastname: Zhuravin
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000473:pathology / Q000503:physiopathology; D003071:Cognition; D049229:Dendritic Spines / Q000473:pathology; D004622:Embryo, Mammalian / Q000473:pathology / Q000503:physiopathology; D047108:Embryonic Development; D005260:Female; D007103:Immobilization / Q000009:adverse effects*; D010296:Parietal Lobe / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000503:physiopathology; D049188:Prenatal Injuries / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological