title: Spontaneous hemarthrosis following fibrinolytic therapy for acute myocardial infarction: a case report and literature review.
abstract: Background Despite the widespread use of fibrinolytic therapy and the numerous reports on its bleeding complications, spontaneous hemarthrosis following fibrinolytic therapy is quite rare. Case Report We describe in this report a patient with no previous history of articular disease who developed a spontaneous right knee bloody effusion following fibrinolytic therapy using rt-PA for acute ST-elevation myocardial infarction. Furthermore, we provide a review of all cases of spontaneous hemarthrosis documented so far in the literature. Conclusions Several pre-existing joint diseases may predispose to hemarthrosis following fibrinolytic therapy, even in patients who deny previous or current articular disorders. Therefore, hemorrhage should be considered in the differential diagnosis of mono-arthritis following fibrinolytic therapy for STEMI.
authors.affiliation: Department of Cardiology, Mansoura University, Faculty of Medicine, Mansoura, Egypt.
authors.forename: Mahmoud M
authors.initials: MM
authors.lastname: Ramadan
authors.affiliation: Department of Orthopedic Surgery, Fujairah Hospital, Ministry of Health, Fujairah , United Arab Emirates.
authors.forename: Iqbal S
authors.initials: IS
authors.lastname: Khan
authors.affiliation: Department of Cardiology, Fujairah Hospital, Ministry of Health, Fujairah, United Arab Emirates.
authors.forename: Ousama
authors.initials: O
authors.lastname: Mahdi
mesh_terms: D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006395:Hemarthrosis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator