title: [Genetic variation may influence the development of persistent postsurgical pain].
abstract: Persistent postsurgical pain is a major clinical problem. It is not fully understood why some patients develop persistent postsurgical pain while others do not. The genetic profile might play an important role in this development. In this article, we summarize the existing studies examining the effects of single nucleotide polymorphisms on the development of persistent postsurgical pain. The evidence in this area is sparse and the results are heterogeneous. Further studies are needed before firm conclusions can be made.
authors.affiliation: Gastroenheden, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. maja.haunstrup.jeppesen@regionh.dk.
authors.forename: Maja Haunstrup
authors.initials: MH
authors.lastname: Jeppesen
authors.forename: Ismail
authors.initials: I
authors.lastname: Gögenur
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics / Q000378:metabolism; D059350:Chronic Pain / Q000235:genetics* / Q000378:metabolism; D006136:GTP Cyclohydrolase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D062556:NAV1.7 Voltage-Gated Sodium Channel / Q000235:genetics / Q000378:metabolism; D010149:Postoperative Pain / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism
chemical_list: C503456:KCNS1 protein, human; D062556:NAV1.7 Voltage-Gated Sodium Channel; C485764:OPRM1 protein, human; D024642:Potassium Channels, Voltage-Gated; D017450:Receptors, Opioid, mu; C486866:SCN9A protein, human; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D006136:GTP Cyclohydrolase