title: [Bacterial toxin-antitoxin systems and perspectives for their application in medicine: a review].
abstract: The structure of various toxin-antitoxin (TA) families and the principles of their action are reviewed. TA loci are widely distributed in the genomes of eubacteria and archaea. Most TA systems are two-component and function in a similar way: a stable toxin alters vitally important cell functions and can be inactivated by a labile antitoxin.
authors.forename: O I
authors.initials: OI
authors.lastname: Demidenok
authors.forename: A V
authors.initials: AV
authors.lastname: Goncharenko
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001424:Bacterial Infections / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans
chemical_list: D001426:Bacterial Proteins