title: Antiadhesive effect of polyurethane foam packing in the guinea pig middle ear.
abstract: CONCLUSIONS
  No significant subepithelial healing differences were found between Gelfoam and polyurethane foam (PUF). However, levels of hyperplasia of the mucosal lining and inflammation were lower with PUF packing. PUF packing is not feasible as a middle ear packing material for abraded mucosa. Further studies are required before clinical application.
  
  
  OBJECTIVE
  To date, there have been few reports on the antiadhesive effect of PUF as a middle ear packing. The purpose of this study was to investigate the antiadhesive effect of PUF soaked with saline in an animal model of mucosal trauma.
  
  
  METHODS
  Bioresorbable PUF soaked with saline was placed over abraded mucosa in the experimental group (n = 7), and compressed Gelfoam soaked with saline was placed in the control group (n = 7). After measurement of auditory brainstem responses (ABRs), the animals were sacrificed 3 weeks after packing placement for histological observation.
  
  
  RESULTS
  The ABR results at postoperative week 3 showed no statistically significant difference between the preoperative and post-packing values. An adhesion pattern with subepithelial thickening was observed in the control group. Adhesion was not observed in the experimental group; however, subepithelial fibrous thickening was noted.
authors.affiliation: Department of Pharmacology, Bio New Drug Development, Chosun University , Gwangju.
authors.forename: Cheol Hee
authors.initials: CH
authors.lastname: Choi
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
mesh_terms: D000818:Animals; D004427:Ear Diseases / Q000517:prevention & control; D004432:Ear, Middle / Q000187:drug effects* / Q000601:surgery; D005781:Gelatin Sponge, Absorbable; D006168:Guinea Pigs; D008297:Male; D013506:Otologic Surgical Procedures / Q000295:instrumentation*; D011140:Polyurethanes / Q000494:pharmacology / Q000627:therapeutic use*; D012965:Sodium Chloride; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D011140:Polyurethanes; D012965:Sodium Chloride; C028279:polyurethane foam
keywords: Gelfoam; abrasion; mucosa; subepithelial fibrous thickening