title: What type of different clinical manifestations can cardiac sarcoidosis present?
abstract: Cardiac sarcoidosis is an infiltrative, granulomatous inflammatory disease of the myocardium. Generally, it can be difficult to diagnose cardiac sarcoidosis clinically because of the non-specific nature of its clinical manifestations. This property can be based on the presence of any clinical evidence of sarcoidosis in the other organs. We present two cases of cardiac sarcoidosis so as to demonstrate its different clinical manifestations. The first patient displayed no cardiac symptoms; the electrocardiogram showed an incidental right bundle branch block. Her cardiac magnetic resonance imaging (CMRI) revealed late-phase opaque material enhancement involving the inferior and inferoseptal segment of the left ventricle. The second patient was severely symptomatic in terms of cardiac involvement, and a transthoracic echocardiogram revealed global hypokinesia and septal brightness; his ejection fraction decreased to 45%. These cases highlighted the challenges encountered in the diagnosis and treatment of cardiac sarcoidosis. CMRI should be considered in all patients who have suspected findings for cardiac involvement.
authors.affiliation: Department of Chest Disease, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Şentürk
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Maraş
authors.forename: Emine
authors.initials: E
authors.lastname: Argüder
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Karalezli
authors.forename: H Canan
authors.initials: HC
authors.lastname: Hasanoğlu
authors.forename: Tuba
authors.initials: T
authors.lastname: Öğüt
authors.forename: Serdal
authors.initials: S
authors.lastname: Baştuğ
authors.forename: Ercan
authors.initials: E
authors.lastname: Karabekir
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D017023:Coronary Angiography; D018450:Disease Progression; D057915:Drug Substitution; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone