title: Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging.
abstract: The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([18F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [18F]FPEB with a commercial reactor-based system.
authors.affiliation: Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Liang
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Yokell
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Raul N
authors.initials: RN
authors.lastname: Jackson
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Rice
authors.affiliation: Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Ronald
authors.initials: R
authors.lastname: Callahan
authors.affiliation: Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.affiliation: Molecular NeuroImaging, LLC, New Haven, CT, 06510 ; Institute for Neurodegenerative Disorders, New Haven, CT, 06510.
authors.forename: David
authors.initials: D
authors.lastname: Alagille
authors.affiliation: Molecular NeuroImaging, LLC, New Haven, CT, 06510 ; Institute for Neurodegenerative Disorders, New Haven, CT, 06510.
authors.forename: Gilles
authors.initials: G
authors.lastname: Tamagnan
authors.affiliation: Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114 ; Advion Inc., 10 Brown Road, Ithaca, NY, 14850.
authors.forename: Thomas Lee
authors.initials: TL
authors.lastname: Collier
authors.affiliation: Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Neil
authors.initials: N
authors.lastname: Vasdev