title: The RCSB Protein Data Bank: views of structural biology for basic and applied research and education.
abstract: The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide. Our efforts over the past 2 years focused on enabling a deeper understanding of structural biology and providing new structural views of biology that support both basic and applied research and education. Herein, we describe recently introduced data annotations including integration with external biological resources, such as gene and drug databases, new visualization tools and improved support for the mobile web. We also describe access to data files, web services and open access software components to enable software developers to more effectively mine the PDB archive and related annotations. Our efforts are aimed at expanding the role of 3D structure in understanding biology and medicine.
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA pwrose@ucsd.edu.
authors.forename: Peter W
authors.identifier: http://orcid.org/0000-0001-9981-9750
authors.initials: PW
authors.lastname: Rose
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Prlić
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Bi
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Wolfgang F
authors.initials: WF
authors.lastname: Bluhm
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Cole H
authors.initials: CH
authors.lastname: Christie
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Shuchismita
authors.initials: S
authors.lastname: Dutta
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Rachel Kramer
authors.initials: RK
authors.lastname: Green
authors.affiliation: Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Goodsell
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Westbrook
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Woo
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Young
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Zardecki
authors.affiliation: RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Berman
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Philip E
authors.identifier: http://orcid.org/0000-0002-7618-7292
authors.initials: PE
authors.lastname: Bourne
authors.affiliation: RCSB Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA 92093, USA RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA sburley@proteomics.rutgers.edu.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Burley
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry; D008967:Molecular Biology / Q000193:education; D058977:Molecular Sequence Annotation; D046912:Multiprotein Complexes / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011487:Protein Conformation; D012106:Research; D012984:Software
chemical_list: D008565:Membrane Proteins; D046912:Multiprotein Complexes; D010455:Peptides; D004364:Pharmaceutical Preparations