title: Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.
abstract: Seven VEGFR small-molecule inhibitors have been approved by the US FDA as anticancer drugs, which confirms the therapeutic value of angiogenesis inhibitors. However, much more evidence indicates that VEGFR inhibition alone is usually not sufficient to block the tumor progress. The potential of some agents targeting VEGFR owes partially to the simultaneous inhibition of additional targets in other signaling pathways. In this review, the crosstalk between VEGFR2 and the additional targets in other signaling pathways, such as EGFR, MET, FGFR, PDGFR, c-Kit, Raf, PI3K and HDAC, and the synergistic effects derived from multitarget activities against these crosstalks are discussed. We also briefly describe the multitarget inhibitors in clinical trials or reported in the literature and patents under the different multitarget categories involving VEGFR2.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ding
authors.forename: Cunlong
authors.initials: C
authors.lastname: Zhang
authors.forename: Mingli
authors.initials: M
authors.lastname: Zhang
authors.forename: Yu Zong
authors.initials: YZ
authors.lastname: Chen
authors.forename: Chunyan
authors.initials: C
authors.lastname: Tan
authors.forename: Ying
authors.initials: Y
authors.lastname: Tan
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D058990:Molecular Targeted Therapy; D064798:Polypharmacology; D020239:Receptor Cross-Talk / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D054852:Small Molecule Libraries; D040301:Vascular Endothelial Growth Factor Receptor-2