title: Calorie restriction in overweight seniors: response of older adults to a dieting study: the CROSSROADS randomized controlled clinical trial.
abstract: We conducted a study designed to evaluate whether the benefits of intentional weight loss exceed the potential risks in a group of community-dwelling obese older adults who were at increased risk for cardiometabolic disease. The CROSSROADS trial used a prospective randomized controlled design to compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition and adipose tissue deposition (Specific Aim #1: To compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition, namely visceral adipose tissue), cardiometabolic disease risk (Specific Aim #2: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on cardiometabolic disease risk), and functional status and quality of life (Specific Aim #3: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on functional status and quality of life). Participants were randomly assigned to one of three groups: Exercise Only (Control) Intervention, Exercise + Diet Quality + Weight Maintenance Intervention, or Exercise + Diet Quality + Weight Loss Intervention. CROSSROADS utilized a lifestyle intervention approach consisting of exercise, dietary, and behavioral components. The development and implementation of the CROSSROADS protocol, including a description of the methodology, detailing specific elements of the lifestyle intervention, assurances of treatment fidelity, and participant retention; outcome measures and adverse event monitoring; as well as unique data management features of the trial results, are presented in this article.
authors.affiliation: a Division of Gerontology, Geriatrics, and Palliative Care , University of Alabama at Birmingham , Birmingham , Alabama , USA.
authors.forename: Marilyn C
authors.initials: MC
authors.lastname: Haas
authors.forename: Eric V
authors.initials: EV
authors.lastname: Bodner
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Brown
authors.forename: David
authors.initials: D
authors.lastname: Bryan
authors.forename: David R
authors.initials: DR
authors.lastname: Buys
authors.forename: Akilah Dulin
authors.initials: AD
authors.lastname: Keita
authors.forename: Lee Anne
authors.initials: LA
authors.lastname: Flagg
authors.forename: Amy
authors.initials: A
authors.lastname: Goss
authors.forename: Barbara
authors.initials: B
authors.lastname: Gower
authors.forename: Martha
authors.initials: M
authors.lastname: Hovater
authors.forename: Gary
authors.initials: G
authors.lastname: Hunter
authors.forename: Christine S
authors.initials: CS
authors.lastname: Ritchie
authors.forename: David L
authors.initials: DL
authors.lastname: Roth
authors.forename: Brooks C
authors.initials: BC
authors.lastname: Wingo
authors.forename: Jamy
authors.initials: J
authors.lastname: Ard
authors.forename: Julie L
authors.initials: JL
authors.lastname: Locher
mesh_terms: D050154:Adiposity; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000407:Alabama; D015992:Body Mass Index; D031204:Caloric Restriction / Q000009:adverse effects; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy / Q000009:adverse effects; D004038:Diet, Reducing / Q000009:adverse effects; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D050177:Overweight / Q000178:diet therapy* / Q000628:therapy; D015431:Weight Loss
keywords: dietary intervention; lifestyle intervention; obesity; older adults; randomized controlled trial; weight loss