title: Essential thrombocytosis accompanied by coagulation factor XII deficiency: a case report.
abstract: Essential thrombocytosis (ET) is a type of myeloproliferative neoplasm with clinical manifestations of thrombosis and hemorrhage, the mechanisms of which remains unclear. Some researches indicated that ET is mainly related to the defect of platelet function and the abnormality of coagulation mechanism. A few reports showed that ET accompanied by acquired hemophilia. However, no evidence of ET with coagulation factor XII deficiency has been published. we here report a case of ET accompanied with coagulation factor XII deficiency, which had clinically significant bleeding tendency.
authors.affiliation: Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.
authors.forename: Zunsong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.
authors.forename: Kehong
authors.initials: K
authors.lastname: Bi
authors.affiliation: Department of Hematology, Qianfoshan Hospital, Shandong University Jinan City, Shandong Province, P. R. China.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Zhu
keywords: Essential thrombocytosis; coagulation factor XII deficiency; myeloproliferative disease; von Willebrand disease