title: Synthesis and characterization of fluorinated derivatives of cresolsulfonphthalein.
abstract: The reaction between dilute fluorine gas and cresolsufonphthalein in acetic acid was investigated. The mono-, di-, and trifluorinated cresolsufonphthalein derivatives were isolated and characterized. These compounds possessed the properties of pH indicators with biologically relevant pKavalues (6.4-7.5) and the absorption maxima of the basic forms at 582-592 nm. This method can be used for synthesis of positron-emitting18F-labeled pH indicators with potential application for non-invasivein vivopH measurement in biological objects.
authors.affiliation: Department of Radiology, School of Medicine University of Pennsylvania, Philadelphia., PA 19104 ; Department of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, PA 19104.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kachur
authors.affiliation: Department of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, PA 19104.
authors.forename: Diana
authors.initials: D
authors.lastname: Sardelis
authors.affiliation: Department of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, PA 19104.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bentzley
authors.affiliation: Department of Radiology, School of Medicine University of Pennsylvania, Philadelphia., PA 19104.
authors.forename: Anatoliy V
authors.initials: AV
authors.lastname: Popov
authors.affiliation: Department of Radiology, School of Medicine University of Pennsylvania, Philadelphia., PA 19104.
authors.forename: E James
authors.initials: EJ
authors.lastname: Delikatny
authors.affiliation: Department of Radiology, School of Medicine University of Pennsylvania, Philadelphia., PA 19104.
authors.forename: Joel
authors.initials: J
authors.lastname: Karp
keywords: Cresol Purple; Fluorine; electrophilic fluorination; pH measurement