title: Effect of a high-fat meal containing conventional or high-oleic peanuts on post-prandial lipopolysaccharide concentrations in overweight/obese men.
abstract: BACKGROUND
  An increased plasma lipopolysaccharide (LPS) concentration may favour metabolic disorders such as insulin resistance. The meal composition influences plasma LPS concentrations. The present study aimed to investigate the effect of the acute consumption of a high-fat meal (49% of energy from fat) containing conventional or high-oleic peanuts on post-prandial LPS concentrations and its relationship with lipaemia and insulinaemia in overweight and obese men.
  
  
  METHODS
  The test meal consisted of a shake containing conventional peanuts (CVP; n = 21), high-oleic peanuts (HOP; n = 23) or a control biscuit (CT; n = 21). Blood samples were collected in the fasting state and 1, 2 and 3 h post-prandially. LPS, insulin, lipids and glucose concentrations were assessed.
  
  
  RESULTS
  LPS concentrations were lower in CVP [mean (SE) 0.7 (0.5) EU mL(-1) ] and HOP [1.0 (0.9) EU mL(-1) ] groups compared to CT [1.6 (1.2) EU mL(-1) ] at 3 h post-prandially. Triacylglycerol and insulin concentrations increased in all groups. Triacylglycerol started to increase only after 2 h in the CVP and HOP groups. LPS correlated positively with triacylglycerol. Insulin returned to basal concentrations at 3 h only in the CVP and HOP groups.
  
  
  CONCLUSIONS
  The acute consumption of peanuts delayed the increase in serum triacylglycerol and favoured the quicker return of insulin to basal concentrations, especially in the CVP group. Our results suggest that the consumption of conventional or high-oleic peanuts may help to reduce the risk of endotoxaemia and metabolic disorders.
authors.affiliation: Department of Nutrition, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: A P B
authors.initials: AP
authors.lastname: Moreira
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: T F S
authors.initials: TF
authors.lastname: Teixeira
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: R D M
authors.initials: RD
authors.lastname: Alves
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: M C G
authors.initials: MC
authors.lastname: Peluzio
authors.affiliation: Department of Pharmacy and Nutrition, Universidade Federal do Espírito Santo, Alegre, Brazil.
authors.forename: N M B
authors.initials: NM
authors.lastname: Costa
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Bressan
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mattes
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: R C G
authors.initials: RC
authors.lastname: Alfenas
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D010367:Arachis / Q000737:chemistry; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D004734:Energy Metabolism; D005215:Fasting; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D062407:Meals; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D019301:Oleic Acid / Q000008:administration & dosage* / Q000032:analysis; D050177:Overweight / Q000097:blood*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D008070:Lipopolysaccharides; D014280:Triglycerides; D019301:Oleic Acid
keywords: insulin; lipopolysaccharide; oleic acid; peanut