title: Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study.
abstract: BACKGROUND
  The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have been shown to be prognostic factors in some gastrointestinal and pancreatic cancers.
  
  
  METHODS
  Forty-two patients with SCEC were subjected to a multimodal regimen of concurrent neoadjuvant chemoradiotherapy (CRT) followed by surgery. We retrospectively analyzed the impact of pretreatment values of serum leptin, adiponectin, resistin, soluble leptin receptor, C-reactive protein, TNF alpha, leukocytes, and indices of nutritional status (BMI, plasma total protein, albumin, cholesterol, and triacylglycerols) on overall survival (OS).
  
  
  RESULTS
  Univariate analysis revealed significant a negative correlation between OS and serum adiponectin (p=0.027), and a positive relationship was found between serum albumin (p=0.002), cholesterol (p=0.049) level, and OS. In multivariate analysis, only the trend (p=0.086) for negative serum adiponectin association with the OS was observed.
  
  
  CONCLUSIONS
  In men with SCEC treated by neoadjuvant concurrent CRT and esophagectomy, high pretreatment level of serum adiponectin was associated with shorter OS while the serum albumin and cholesterol were associated with longer OS.
authors.affiliation: Clinic of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Milada
authors.initials: M
authors.lastname: Zemanová
authors.affiliation: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Staňková
authors.affiliation: Clinic of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Ušiakova
authors.affiliation: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Tvrzická
authors.affiliation: 3rd Clinic of Surgery, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Alexandr
authors.initials: A
authors.lastname: Pazdro
authors.affiliation: Clinic of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Luboš
authors.initials: L
authors.lastname: Petruželka
authors.affiliation: 4rd Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zeman
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000601:surgery / Q000628:therapy*; D059248:Chemoradiotherapy; D004938:Esophageal Neoplasms / Q000097:blood* / Q000601:surgery / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010865:Pilot Projects; D011300:Preoperative Care; D016016:Proportional Hazards Models; D016019:Survival Analysis
chemical_list: D052242:Adiponectin