title: Late effects of childhood cancer and its treatment.
abstract: Treatment for childhood cancer with chemotherapy, radiation and/or hematopoietic cell transplant can result in adverse sequelae that may not become evident for many years. A clear understanding of the association between therapeutic exposures and specific long-term complications, and an understanding of the magnitude of the burden of morbidity borne by childhood cancer survivors, has led to the development of guidelines to support lifelong risk-based follow up for this population. It is important to develop interventions to reduce the impact of treatment-related late effects on morbidity and mortality and to continue research regarding the etiopathogenesis of therapy-related cancers and other late effects.
authors.affiliation: Department of Population Sciences, City of Hope, 1500 E. Duarte Rd., DPS-173, Duarte, CA 91010, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Landier
authors.affiliation: Department of Population Sciences, City of Hope, 1500 E. Duarte Rd., DPS-173, Duarte, CA 91010, USA.
authors.forename: Saro
authors.initials: S
authors.lastname: Armenian
authors.affiliation: Department of Population Sciences, City of Hope, 1500 E. Duarte Rd., DPS-173, Duarte, CA 91010, USA. Electronic address: sbhatia@coh.org.
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D009017:Morbidity; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D018570:Risk Assessment; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; Childhood; Late effects; Treatment