title: Meta analysis of olfactory ensheathing cell transplantation promoting functional recovery of motor nerves in rats with complete spinal cord transection.
abstract: OBJECTIVE
  To evaluate the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection.
  
  
  METHODS
  A computer-based online search of Medline (1989-2013), Embase (1989-2013), Cochrane library (1989-2013), Chinese Biomedical Literature Database (1989-2013), China National Knowledge Infrastructure (1989-2013), VIP (1989-2013), Wanfang databases (1989-2013) and Chinese Clinical Trial Register was conducted to collect randomized controlled trial data regarding olfactory ensheathing cell transplantation for the treatment of complete spinal cord transection in rats.
  
  
  METHODS
  Randomized controlled trials investigating olfactory ensheathing cell transplantation and other transplantation methods for promoting neurological functional recovery of rats with complete spinal cord transection were included in the analysis. Meta analysis was conducted using RevMan 4.2.2 software.
  
  
  METHODS
  Basso, Beattie and Bresnahan scores of rats with complete spinal cord transection were evaluated in this study.
  
  
  RESULTS
  Six randomized controlled trials with high quality methodology were included. Meta analysis showed that Basso, Beattie and Bresnahan scores were significantly higher in the olfactory ensheathing cell transplantation group compared with the control group (WMD = 3.16, 95% CI (1.68, 4.65); P < 0.00001).
  
  
  CONCLUSIONS
  Experimental studies have shown that olfactory ensheathing cell transplantation can promote the functional recovery of motor nerves in rats with complete spinal cord transection.
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Taian Central Hospital, Taian, Shandong Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Haiong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Junxiong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Meihui
authors.initials: M
authors.lastname: Piao
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Ren
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China.
authors.forename: Liangbi
authors.initials: L
authors.lastname: Xiang
keywords: BBB scores; cell transplantation; complete transection; meta analysis; nerve regeneration; olfactory ensheathing cells; spinal cord injury