title: In vitro degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy by hydrofluoric acid treatment.
abstract: In this paper, Mg-Nd-Zn-Zr alloy (denoted as JDBM) coated with hydrofluoric acid (HF) chemical conversion film (MgF2) was researched as a potential biodegradable cardiovascular stent material. The microstructures, in vitro degradation and biocompatibility were investigated. The field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) showed that a compact MgF2 film was formed on the surface of JDBM. The corrosion rate decreased in artificial plasma from 0.337 to 0.253 mm·y(-1) and the electrochemical measurement demonstrated that the corrosion resistance of JDBM alloy could be obviously improved due to the protective MgF2 film on the surface of the substrate. Meanwhile, the hemolysis ratio of JDBM decreased from 52.0% to 10.1% and the cytotoxicity met the requirement of cellular application after HF treatment. In addition, JDBM and MgF2 film showed good anti-platelet adhesion, which is a very favorable property for implant material in contact with blood directly.
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Mao
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China; State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, 200240, China. Electronic address: gyyuan@sjtu.edu.cn.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Niu
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zong
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China; State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, 200240, China.
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Ding
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D001792:Blood Platelets / Q000166:cytology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003343:Corrosion; D055664:Electrochemical Techniques; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005459:Fluorides / Q000737:chemistry / Q000633:toxicity; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006858:Hydrofluoric Acid / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry / Q000633:toxicity; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D017616:Magnesium Compounds; C571250:Mg-Nd-Zn-Zr alloy; C031288:magnesium fluoride; D005459:Fluorides; D006858:Hydrofluoric Acid