title: Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer.
abstract: BACKGROUND
  Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics.
  
  
  OBJECTIVE
  In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival.
  
  
  METHODS
  The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa.
  
  
  RESULTS
  Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. Adipo- R1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758 ) and (0.274, 0.232), respectively].
  
  
  CONCLUSIONS
  Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.
authors.affiliation: Department of Gastroenterology, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey E-mail : talatayy@gmail.com.
authors.forename: Talat
authors.initials: T
authors.lastname: Ayyildiz
authors.forename: Enver
authors.initials: E
authors.lastname: Dolar
authors.forename: Nesrin
authors.initials: N
authors.lastname: Ugras
authors.forename: Saduman Balaban
authors.initials: SB
authors.lastname: Adim
authors.forename: Omer
authors.initials: O
authors.lastname: Yerci
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D000368:Aged; D001707:Biopsy, Needle; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D054419:Receptors, Adiponectin / Q000235:genetics*; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D054419:Receptors, Adiponectin