title: Re-operation in pancreas transplantation.
abstract: BACKGROUND
  Surgical complications in pancreas transplantation are associated with increased morbidity and graft loss. The purpose of our study was to determine the frequency of re-operation in early and late postoperative of pancreas transplantation and its impact in relation to graft survival, patient survival, and hospital mortality.
  
  
  METHODS
  We conducted a retrospective study of 238 pancreas transplants performed from 2001 to 2011. We analyzed surgical complications that led to the early and late re-operations by type of transplantation and its relation to pancreas graft survival, patient survival, and hospital mortality.
  
  
  RESULTS
  We studied 61 re-operated patients (25.63%), 58 patients with early re-operation and 3 with late re-operation. The median of re-operations per patient was 1.48 (range, 1 to 5). Seventy-five surgical complications required 90 re-operations. The causes of early re-operations were bleeding (8.8%), pancreas graft thrombosis (6.3%), pancreatitis (2.9%), bowel obstruction (2.1%), leaks (2.1%), and evisceration (1.7%). The hospital mortality rate was 0.43%. Pancreas graft survival at 1 and 5 years is higher in the group of non-re-operated than in the re-operated group (98% vs 74% and 93% vs 57%; P = .0001). Patient survival at 1 year is slightly higher in the non-re-operated group, but with no significant differences (99% vs 97%), and at 5 years the patient survival in the non-re-operated group is higher than in the re-operated group (98% vs 91%; P = .011).
  
  
  CONCLUSIONS
  Surgical complications required re-operations that were associated with higher morbidity and lower pancreas graft and patient survival.
authors.affiliation: Servicio de Cirugía Bilio-Pancreático, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address: cclavelc@hotmail.com.
authors.forename: C E
authors.initials: CE
authors.lastname: Cornejo-Carrasco
authors.affiliation: Servicio de Cirugía Bilio-Pancreático, Hospital Clínic de Barcelona, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Fernández-Cruz
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D015996:Survival Rate