title: [Changes in Incidence and Mortality Trends of Head and Neck Cancer in Rhineland-Palatinate, 2000-2009].
abstract: BACKGROUND
  Epidemiological data on HNC are often reported aggregated despite their anatomical and histological heterogeneity. In Germany, few studies have analyzed incidence and mortality trends separately for specific anatomic sites. Furthermore, little is known about whether the incidence of HPV-associated tumour entities of the head and neck region has increased.
  
  
  METHODS
  Based on cancer registry data from Rhineland-Palatinate from 2000 to 2009, age-standardized incidence and mortality rates were calculated for all HNC sites and localisation groups that might be HPV-associated according to the literature. Trends were analyzed by Joinpoint regression and reported as the annual percentage change (APC).
  
  
  RESULTS
  Throughout the study period, 8 055 incident cases and 3 177 deaths were identified. The incidence rates of overall HNC increased among women (APC:+2.2%) and declined slightly among men (- 0.9%). Significantly increasing incidence rates among women were seen for tumours of the oral cavity (+2.7%) and the oropharynx (+3.6%). Among men, a significant decrease in incidence rates for tumours of the hypopharynx (-3.4%) and the larynx (-2.7%) are noteworthy. Cancers at HPV-associated sites showed increased incidence rates in men (+3.3%) and women (+4.3%). A decrease in mortality was found for tumours of the larynx in both sexes (-5.8% men,-9.1% women).
  
  
  CONCLUSIONS
  A detailed analysis by localisation of HNC showed significant and often opposing trends for men and women regarding incidence and mortality.
authors.affiliation: Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz.
authors.forename: O
authors.initials: O
authors.lastname: Bayer
authors.affiliation: Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz.
authors.forename: M
authors.initials: M
authors.lastname: Krüger
authors.affiliation: Klinik für Hals-, Nasen-, Ohrenheilkunde und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz.
authors.forename: D
authors.initials: D
authors.lastname: Koutsimpelas
authors.affiliation: Krebsregister Rheinland-Pfalz, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz.
authors.forename: K
authors.initials: K
authors.lastname: Emrich
authors.affiliation: Krebsregister Rheinland-Pfalz, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz.
authors.forename: M
authors.initials: M
authors.lastname: Ressing
authors.affiliation: Krebsregister Rheinland-Pfalz, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz.
authors.forename: S R
authors.initials: SR
authors.lastname: Zeissig
authors.affiliation: Centre Hospitalier Universitaire Vaudois (CHUV), Klinik für Hals-, Nasen-, Ohrenheilkunde, Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.affiliation: Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz.
authors.forename: S
authors.initials: S
authors.lastname: Singer
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000453:epidemiology* / Q000401:mortality*; D012042:Registries; D012737:Sex Factors; D015996:Survival Rate / Q000639:trends