title: Animal models of tuberculosis: zebrafish.
abstract: Over the past decade the zebrafish (Danio rerio) has become an attractive new vertebrate model organism for studying mycobacterial pathogenesis. The combination of medium-throughput screening and real-time in vivo visualization has allowed new ways to dissect host pathogenic interaction in a vertebrate host. Furthermore, genetic screens on the host and bacterial sides have elucidated new mechanisms involved in the initiation of granuloma formation and the importance of a balanced immune response for control of mycobacterial pathogens. This article will highlight the unique features of the zebrafish-Mycobacterium marinum infection model and its added value for tuberculosis research.
authors.affiliation: Department of Pediatric Infectious Diseases and Immunology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands Department of Medical Microbiology and Infection control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
authors.forename: Lisanne M
authors.initials: LM
authors.lastname: van Leeuwen
authors.affiliation: Department of Pediatric Infectious Diseases and Immunology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
authors.forename: Astrid M
authors.initials: AM
authors.lastname: van der Sar
authors.affiliation: Department of Pediatric Infectious Diseases and Immunology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands Department of Molecular Microbiology, VU University, 1081 HV Amsterdam, The Netherlands.
authors.forename: Wilbert
authors.initials: W
authors.lastname: Bitter
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D009165:Mycobacterium Infections, Nontuberculous / Q000503:physiopathology; D014376:Tuberculosis / Q000503:physiopathology*; D015027:Zebrafish / Q000382:microbiology*