title: Evaluation of the biocompatibility of two magnesium alloys as degradable implant materials in comparison to titanium as non-resorbable material in the rabbit.
abstract: The aim of this study is to compare the biocompatibility of the two magnesium based alloys LAE442 and LANd442 with that of titanium. For this purpose, cylindrical implants were introduced into the medullary cavity of rabbit's tibiae for 4 and 8 weeks. Animals without any implant served as a control. In the follow-up, clinical, X-ray and μCT-investigations were performed to evaluate the reactions of the bone towards the implanted materials. After euthanasia, ex vivo μCT- and histological investigations were performed to verify the results of the in vivo tests. It could be shown that all materials induce changes in the bone. Whereas LANd442 caused the most pronounced reactions, such as increasing bone volume and bone porosity and decreasing bone density, titanium showed the most bone-implant contact by forming trabeculae. The tibiae of rabbits without implants also reacted by forming cavities, it is therefore assumed that the surgery method itself influences the bone.
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hanover, Bünteweg 9, 30559 Hanover, Germany. carolin.hampp@tiho-hannover.de
authors.forename: Carolin
authors.initials: C
authors.lastname: Hampp
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hanover, Bünteweg 9, 30559 Hanover, Germany. Electronic address: nina.angrisani@tiho-hannover.de.
authors.forename: Nina
authors.initials: N
authors.lastname: Angrisani
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hanover, Bünteweg 9, 30559 Hanover, Germany. Electronic address: janin.reifenrath@tiho-hannover.de.
authors.forename: Janin
authors.initials: J
authors.lastname: Reifenrath
authors.affiliation: Institute of Materials Science, Leibniz University Hanover, An der Universität 2, 30823 Garbsen, Germany. Electronic address: dirk.bormann@trimet.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Bormann
authors.affiliation: Institute of Materials Science, Leibniz University Hanover, An der Universität 2, 30823 Garbsen, Germany. Electronic address: seitz@iw.uni-hannover.de.
authors.forename: Jan-Marten
authors.initials: JM
authors.lastname: Seitz
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hanover, Bünteweg 9, 30559 Hanover, Germany. Electronic address: ameylin@lmu.de.
authors.forename: Andrea
authors.initials: A
authors.lastname: Meyer-Lindenberg
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects; D004195:Disease Models, Animal; D008274:Magnesium / Q000737:chemistry* / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D016062:Porosity; D011817:Rabbits; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D014025:Titanium / Q000737:chemistry*; D014057:Tomography, X-Ray Computed
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium; D008274:Magnesium