title: [Modeling of schizophrenia with Levodopa + Carbidopa].
abstract: Animal experimental modeling of mental disorders helps revealing mechanisms of the diseases and identifying effective methods of their treatment. The aim this study was to develop a new model of schizophrenia by oral Levodopa + Carbidopa (LC) administration. It was found that introduction of LC to rats induced a significant reduction of emotional reactions, hypersensitivity to a sound, a decreased exploratory activity and stereotype behavior, locomotor hyperactivity in some rats. It is concluded that LC introduction to rats may be used as an alternative dopaminergic animal model of schizophrenia.
authors.forename: E O
authors.initials: EO
authors.lastname: Kucher
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Egorov
authors.forename: N A
authors.initials: NA
authors.lastname: Chernikova
authors.forename: E V
authors.initials: EV
authors.lastname: Filatova
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002230:Carbidopa / Q000009:adverse effects* / Q000494:pharmacology; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000494:pharmacology; D004338:Drug Combinations; D007980:Levodopa / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000139:chemically induced* / Q000503:physiopathology*
chemical_list: D018491:Dopamine Agonists; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa