title: Hypofractionated stereotactic radiotherapy after transarterial chemoembolisation failure in an unresectable hepatocellular carcinoma: a case presentation.
abstract: Introduction. Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma. There is no standard treatment after transarterial chemoembolization failure. We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and a long cancer control with hypofractionated stereotactic radiotherapy after transarterial chemoembolization failure. Case Presentation. A 70-year-old Caucasian woman was treated with transarterial chemoembolization for advanced hepatocellular, but no cancer control was obtained. A hypofractionated stereotactic radiotherapy was planned delivering 40 Gy in 5 fractions. A dramatic reduction in alpha-fetoprotein was observed. Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas. Computerised tomography scan showed a 90% objective tumour response, then a complete remission at 3 and 6 months after treatment, respectively. Status of patient remained unchanged for 2 years. Conclusions. Hypofractionated stereotactic radiotherapy can improve survival and prognosis of unresectable hepatocellular carcinoma patient.
authors.affiliation: Department of Radiation Oncology, University Hospital "S. Anna," Corso Giovecca 203, 44100 Ferrara, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fiorica
authors.affiliation: Department of Radiation Oncology, University Hospital "S. Chiara," Via Roma 67, 56126 Pisa, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Greco
authors.affiliation: Department of Gastroenterology, University Hospital "S. Anna," Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Boccia
authors.affiliation: Department of Internal Medicine, Section of Interventional Ultrasound, University Hospital "S. Anna," Via Aldo Moro 8, 44124 Ferrara, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Sartori
authors.affiliation: Department of Radiation Oncology, University Hospital "S. Anna," Corso Giovecca 203, 44100 Ferrara, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Stefanelli
authors.affiliation: Department of Radiation Oncology, University Hospital "S. Anna," Corso Giovecca 203, 44100 Ferrara, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cartei
authors.affiliation: Department of Radiation Oncology, University Hospital "S. Anna," Corso Giovecca 203, 44100 Ferrara, Italy ; Department of Radiation Oncology, University Hospital "S. Chiara," Via Roma 67, 56126 Pisa, Italy.
authors.forename: Stefano
authors.identifier: 0000-0003-3018-2338
authors.initials: S
authors.lastname: Ursino