title: [High fat diet-induced molecular and physiological dysfunction of the urinary bladder].
abstract: BACKGROUND
  Obesity with its multiple comorbidities has become a global pandemia. We here report on the pathophysiological aspects of obesity-associated urinary bladder dysfunctions.
  
  
  METHODS
  Our results are based on multiple in vitro and in vivo studies including a high fat diet (HFD) rat animal model of which the details are given in the cited publications.
  
  
  RESULTS
  In cultured human detrusor muscle cells, obesity-related pathophysiological mechanisms were directly induced by the saturated free fatty acid palmitate. In HFD animals, we found serious fibrosis of the bladder wall and downregulation of the muscarinic M3-receptor leading to diminished contractility of the urinary bladder. Bariatric surgical intervention (sleeve gastrectomy) reversed the fibrosis.
  
  
  CONCLUSIONS
  Our results support the relevance of obesity for urological bladder dysfunction. The epidemic dimension of obesity with its steadily growing number of cases requires a re-evaluation of this pathological condition in the urological context.
authors.affiliation: Klinik für Herzchirurgie, Herzzentrum Leipzig, Leipzig, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Oberbach
authors.forename: N
authors.initials: N
authors.lastname: Schlichting
authors.forename: M
authors.initials: M
authors.lastname: Heinrich
authors.forename: Y
authors.initials: Y
authors.lastname: Kullnick
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: V
authors.initials: V
authors.lastname: Adams
authors.forename: J-W
authors.initials: JW
authors.lastname: Stolzenburg
authors.forename: J
authors.initials: J
authors.lastname: Neuhaus
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D059305:Diet, High-Fat; D006801:Humans; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology*; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D001743:Urinary Bladder / Q000503:physiopathology*; D001745:Urinary Bladder Diseases / Q000209:etiology* / Q000503:physiopathology*
chemical_list: D016207:Cytokines; D020543:Proteome