title: Multifocal microinvasive squamous cell carcinoma with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, vagina, and left salpinx diagnosed five years after conization of cervical CIS.
abstract: BACKGROUND
  Multifocal microinvasive squamous cell carcinoma (SCC) with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, salpinx, and vagina is extremely unusual.
  
  
  METHODS
  The authors present a case of 69-year-old woman with hydrometra who was found to have multifocal microinvasive SCC in the endometrium. The CIS had spread superficially throughout the entire endometrium up to the fundus, completely replacing the epithelium. The uterine cervix, vaginal surface and left salpingeal mucosa were involved. She had previously undergone conization due to cervical CIS five years prior. The pathologic reports showed clear resection margins at that time.
  
  
  CONCLUSIONS
  The present case suggests that CIS in the endometrium spread back to the cervix and vagina, although the definite origin of the first CIS was not determined.
authors.forename: S W
authors.initials: SW
authors.lastname: Yang
authors.forename: W Y
authors.initials: WY
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Yoon
authors.forename: J Y
authors.initials: JY
authors.lastname: Lim
authors.forename: S J
authors.initials: SJ
authors.lastname: Leet
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005187:Fallopian Tubes / Q000473:pathology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014599:Uterus / Q000473:pathology*; D014621:Vagina / Q000473:pathology*