title: Synthesis of hierarchical porous bioactive glasses for bone tissue regeneration.
abstract: A novel hierarchical porous bioactive glasses were synthesised with cattail stem and triblock polyethylene oxide-propylene oxide block copolymer (P123) as macroporous template and mesoporous template, respectively. The structural and textural properties of materials were characterised by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectroscopy, nitrogen adsorption-desorption, energy dispersive spectrometer and vibrating sample magnetometer technique. The results reveal the bioglasses possess multilevel porous structure with the macroporous size about 50 μm and the mesopore with the diameter of 3.86 nm. Furthermore, metformin HCl was used as the model drug. The drug release kinetics and hydroxyapatite (HAP, (Ca10(PO4)6(OH)2)) inducing-growth ability of the composites were studied, respectively. The system exhibits the fast HAP inducing-growth ability and long-term drug delivery, making them a good candidate for bone tissue regeneration.
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Bian
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, People's Republic of China. quferngyu2012@aliyun.com.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Qu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D002516:Ceramics / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D009584:Nitrogen / Q000032:analysis / Q000378:metabolism; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D017886:Durapatite; D009584:Nitrogen