title: [Progress in mesenchymal stem cells aging].
abstract: OBJECTIVE
  To comprehensively analyze the recent advancements in the field of mesenchymal stem cells (MSCs) aging, and summary its achievements and its difficulty at the present.
  
  
  METHODS
  The literature about MSCs aging was reviewed and analyzed.
  
  
  RESULTS
  Inducible telomerase reactivation of MSCs is successful to extend the life span of senescent cells, but it also has potential safety hazard. The age range presented in the research of age-related cell senescence is inconsistent, resulting in different outcomes. Many ways to improve cell in vitro culture conditions will help delay aging. Recent research indicates that oxidative stress theory is seemed to not completely explain cell aging.
  
  
  CONCLUSIONS
  Further research of MSCs aging mechanism will help the tissue engineering transform to clinical application.
authors.forename: Haitang
authors.initials: H
authors.lastname: Yang
authors.forename: Heng
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000375:Aging; D016922:Cellular Senescence; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D018384:Oxidative Stress; D019098:Telomerase / Q000378:metabolism*; D023822:Tissue Engineering / Q000639:trends*
chemical_list: D019098:Telomerase