title: Building robust transcriptomes with master splicing factors.
abstract: Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Mohini
authors.initials: M
authors.lastname: Jangi
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: sharppa@mit.edu.
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Sharp
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D005246:Feedback; D018507:Gene Expression Regulation, Developmental; D006706:Homeostasis; D006801:Humans; D009928:Organ Specificity; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D059467:Transcriptome
chemical_list: D016601:RNA-Binding Proteins; D014157:Transcription Factors