title: The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.
authors.affiliation: Department of Oncology-Pathology, Immune and Gene Therapy Lab, CCK, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Daneshmanesh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hojjat-Farsangi
authors.forename: Ali
authors.initials: A
authors.lastname: Moshfegh
authors.forename: Abdul Salam
authors.initials: AS
authors.lastname: Khan
authors.forename: Eva
authors.initials: E
authors.lastname: Mikaelsson
authors.forename: Anders
authors.initials: A
authors.lastname: Österborg
authors.forename: Håkan
authors.initials: H
authors.lastname: Mellstedt
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D057050:Receptor Tyrosine Kinase-like Orphan Receptors; D058570:TOR Serine-Threonine Kinases; C078716:ROR1 protein, human
keywords: PI3K/AKT/mTOR pathway; ROR1; apoptosis; chronic lymphocytic leukaemia; monoclonal antibodies