title: Preparation and characterization of selenite substituted hydroxyapatite.
abstract: Selenite-substituted hydroxyapatite (Se-HA) with different Se/P ratios was synthesized by a co-precipitation method, using sodium selenite (Na2SeO3) as a Se source. Selenium has been incorporated into the hydroxyapatite lattice by partially replacing phosphate (PO4(3-)) groups with selenite (SeO3(2-)) groups. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) techniques reveal that substitutions of phosphate groups by selenite groups cause lower carbonate groups occupying at phosphate sites and change the lattice parameters of hydroxyapatite. The powders obtained are nano-crystalline hydroxyapatite when the Se/P ratios are not more than 0.1. The particle shape of Se-HA has not been altered compared with selenite-free hydroxyapatite but Se-incorporation reduces the crystallite size. The crystallinity was reduced as the Se/P ratios increased until amorphous phase (Se/P=0.3) appeared in the Se-HA powder obtained, and then another crystal phase presented as calcium selenite hydrate (Se/P=10). In addition, the sintering tests show that the Se-HA powders with the Se/P ratio of 0.1 have thermal stability at 900 °C for 2 h; hence they have great potential in the fabrication of bone repair scaffolds.
authors.affiliation: Advance Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Advance Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Advance Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Advance Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China; China-Korea Center for Biomaterials and Nano-biotechnology, Life Science Building, 1037 Luoyu Road, Wuhan 430074, PR China. Electronic address: caltary@gmail.com.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D003460:Crystallization; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D011208:Powders; D020887:Selenious Acid / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D011208:Powders; D017886:Durapatite; D020887:Selenious Acid