title: Determinants of medication non-adherence in Egyptian patients with systemic lupus erythematosus: Sharkia Governorate.
abstract: The aim of the study was to identify the determinants of adherence to medication among Egyptian patients with SLE. A single-center cross-sectional study was conducted among Egyptian patients with SLE. Adherence to medication was measured via The Compliance Questionnaire for Rheumatology-19, and the patients were classified as non-adherers if they were taking <80% of their medication correctly. Predictors of adherence to SLE medication were determined by multiple logistic regressions. The mean age of participants was 30.9 ± 11.7 years. Females constituted 95% of all participants. Thirty-eight (%) were taking <80% of their medication correctly. On logistic regression analysis, the significant independent predictors of medication non-adherence were lower educational level (OR 5.6, 95% CI 2.1-7.3, P < 0.001), very low and low socioeconomic status (OR 2.6, 95% CI 1.6-4.3, P < 0.04), rural residency (OR 3.4, 95% CI 1.4-5, P < 0.01), more number of medications (OR 3.2, 95% CI 2.3-6.9, P < 0.01), and higher depressive symptoms (OR 3.7, 95% CI 1.4-10.2, P < 0.001). The adherence rate reported in this study was quite low. Appropriate adherence enhancing intervention strategies targeted at reducing pill load, minimizing depressive symptoms, and ensuring an uninterrupted access to free services regimen for patients with low socioeconomic status is strongly recommended. More attention should be given to SLE patients who live in rural regions.
authors.affiliation: Department of Rheumatology and Rehabilitation, Zagazig University, 16 El-Emam Ali St. Villat el Jamaa, Zagazig, Egypt, amal_bakry@ymail.com.
authors.forename: Amal B
authors.initials: AB
authors.lastname: Abdul-Sattar
authors.forename: Sahar A
authors.initials: SA
authors.lastname: Abou El Magd
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000523:psychology; D004522:Educational Status; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology / Q000523:psychology; D008297:Male; D055118:Medication Adherence; D016017:Odds Ratio; D011203:Poverty; D012307:Risk Factors; D012424:Rural Population; D011795:Surveys and Questionnaires
chemical_list: D007155:Immunologic Factors