title: Human papillomaviruses-related cancers. Presence and prevention strategies in the Middle east and north African regions.
abstract: Human papillomavirus (HPV) infections are estimated to be the most common sexually transmitted infections worldwide. Meanwhile, it is well established that infection by high-risk HPVs is considered the major cause of cervical cancer since more than 96% of these cancers are positive for high-risk HPVs, especially types 16 and 18. Moreover, during the last 2 decades, numerous studies pointed-out the possible involvement of high-risk HPV in several human carcinomas including head and neck, colorectal and breast cancers. The association between high-risk HPVs and cervical cancer and potentially other human malignancies would necessitate the introduction of vaccines which were generated against the 2 most frequent high-risk HPVs (types 16 and 18) worldwide, including the Middle East (ME) as well as North African countries. The presence of high-risk HPVs in the pathogenesis of human cancers in the ME, which is essential in order to evaluate the importance of vaccination against HPVs, has not been fully investigated yet. In this review, we present an overview of the existing epidemiological evidence regarding the presence of HPV in human cancers in the ME and the potential impact of vaccination against HPV infections and its outcome on human health in this region.
authors.affiliation: a ABS Research & Development; Montréal, QC Canada.
authors.forename: Ala-Eddin
authors.initials: AE
authors.lastname: Al Moustafa
authors.forename: Rana
authors.initials: R
authors.lastname: Al-Awadhi
authors.forename: Nabiha
authors.initials: N
authors.lastname: Missaoui
authors.forename: Ishag
authors.initials: I
authors.lastname: Adam
authors.forename: Raika
authors.initials: R
authors.lastname: Durusoy
authors.forename: Lina
authors.initials: L
authors.lastname: Ghabreau
authors.forename: Nizar
authors.initials: N
authors.lastname: Akil
authors.forename: Hussain Gadelkarim
authors.initials: HG
authors.lastname: Ahmed
authors.forename: Amber
authors.initials: A
authors.lastname: Yasmeen
authors.forename: Ghazi
authors.initials: G
authors.lastname: Alsbeih
mesh_terms: D000352:Africa, Northern / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008877:Middle East / Q000453:epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D053918:Papillomavirus Vaccines / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines
keywords: HPVs; HPVs-cancers; Middle East; North Africa; Vaccination