title: Inflammation and hypertension: new understandings and potential therapeutic targets.
abstract: Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.
authors.affiliation: Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: De Miguel
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Rudemiller
authors.forename: Justine M
authors.initials: JM
authors.lastname: Abais
authors.forename: David L
authors.initials: DL
authors.lastname: Mattson
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D019468:Disease Management; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000276:immunology / Q000628:therapy; D007111:Immunity, Cellular; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines