title: Bicuspid aortic valves and thoracic aortic aneurysms in patients with intracranial aneurysms.
abstract: OBJECTIVE
  The purpose of this study was to determine the prevalence of bicuspid aortic valves (BAVs) and thoracic ascending aortic aneurysms (TAAs) in a retrospective cohort of patients treated for intracranial aneurysms (IAs).
  
  
  METHODS
  Patients treated for IA at our institution between 2002 and 2011 were identified and their clinical records reviewed. Those without an echocardiogram of sufficient quality to assess the aortic valve were excluded. The prevalence of BAVs and TAAs in this remaining cohort was determined based on echocardiography reports, medical records, and cross-sectional chest imaging.
  
  
  RESULTS
  Of 1,047 patients, 317 had adequate echocardiography for assessment of BAV. Of these, 82 also had cross-sectional chest imaging. Of the 317 patients, 2 had BAV and 15 had TAA. The prevalence of BAVs (0.6%, 95% confidence interval 0.2%-2.2%) was similar to population prevalence estimates for this condition; however, the prevalence of TAAs (4.7%, 95% confidence interval 2.9%-7.6%) was larger than expected in a normal age- and sex-matched population.
  
  
  CONCLUSIONS
  Our data demonstrate an association between IA and TAA, but not independently for BAV.
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO. goyalm@mir.wustl.edu.
authors.forename: Manu S
authors.initials: MS
authors.lastname: Goyal
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO.
authors.forename: Ravi
authors.initials: R
authors.lastname: Gottumukkala
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Bhalla
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kates
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Zipfel
authors.affiliation: From the Mallinckrodt Institute of Radiology (M.S.G., R.G., S.B., C.P.D.), Cardiovascular Division of the Department of Internal Medicine (A.K.), and Departments of Neurology and Neurosurgery (G.J.Z., C.P.D.), Washington University School of Medicine, St. Louis, MO.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Derdeyn
mesh_terms: D000328:Adult; D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000453:epidemiology*; D001017:Aortic Coarctation / Q000453:epidemiology; D001021:Aortic Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000082882:Bicuspid Aortic Valve Disease; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed