title: Tumour-to-tumour metastasis: male breast carcinoma metastasis arising in an extrapleural solitary fibrous tumour - a case report.
abstract: BACKGROUND
  Tumour-to-tumour metastasis (TTM) occurs when one tumour metastasises to a separate tumour within the same individual. TTM is observed frequently in breast cancer but has not been described in male breast cancer. In addition reports describing solitary fibrous tumours (SFT) of the pleura hosting other neoplasms' metastases are limited. We report an exceptional case of male breast cancer metastasising to an extrapleural SFT, occurring in the subcutaneous tissue of the back of a 68-year old Caucasian patient.
  
  
  METHODS
  A 68-year old male was diagnosed with a metastasising ductal breast cancer. He was treated by mastectomy of the right breast and axillary lymph-adenectomy. Further staging revealed an increasing subcutaneous expansion located on the patient's back. Excision biopsy confirmed a SFT hosting a breast cancer metastasis. The patient received palliative chemotherapy but died of disease seven years after initial diagnosis.
  
  
  CONCLUSIONS
  The abundance of blood vessels within these lesions might predispose SFTs for an involvement in TTM. This case describes the possibility of concurrent rare occurrences and reminds clinicians, as well as pathologists, to be open-minded and fastidious about their differential diagnoses, sampling and examination of histological specimens.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_203.
authors.affiliation: Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. susanne.scheipl@gmx.at.|University College London Cancer Institute, 72 Huntley Street, London, WC1 6BT, UK. susanne.scheipl@gmx.at.
authors.forename: Susanne
authors.initials: S
authors.lastname: Scheipl
authors.affiliation: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria. farid.moinfar@medunigraz.at.
authors.forename: Farid
authors.initials: F
authors.lastname: Moinfar
authors.affiliation: Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. andreas.leithner@medunigraz.at.
authors.forename: Andreas
authors.initials: A
authors.lastname: Leithner
authors.affiliation: Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. patrick.sadoghi@medunigraz.at.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sadoghi
authors.affiliation: University College London Cancer Institute, 72 Huntley Street, London, WC1 6BT, UK. mette.jorgensen@ucl.ac.uk.
authors.forename: Mette
authors.initials: M
authors.lastname: Jorgensen
authors.affiliation: Center for Medical Research, Cell Culture Facility, Medical University of Graz, Stiftingtalstrasse 24, 8010, Graz, Austria. beate.rinner@medunigraz.at.
authors.forename: Beate
authors.initials: B
authors.lastname: Rinner
authors.affiliation: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria. bernadette.liegl-atzwanger@medunigraz.at.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Liegl
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001415:Back; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018567:Breast Neoplasms, Male / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008297:Male; D008408:Mastectomy; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary; D010166:Palliative Care; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D040521:Subcutaneous Tissue / Q000737:chemistry / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor