title: MicroRNA-mediated regulation of KRAS in cancer.
abstract: While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT, 06511, USA. minlee.kim@yale.edu.|Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. minlee.kim@yale.edu.
authors.forename: Minlee
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. fslack@bidmc.harvard.edu.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Slack
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D011905:Genes, ras; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins