title: Long-term and controlled release of chlorhexidine-copper(II) from organically modified montmorillonite (OMMT) nanocomposites.
abstract: Drug/metal ion complexes exhibit improved antimicrobial activity and intercalating the above complexes into the interlayer of clay endows a long-term and controlled-release behavior. In this study, chlorhexidine was first complexed with copper (II) ion and then intercalated into the interlayer of MMT to form chlorhexidine-copper (II)/montmorillonite (CHX-Cu/MMT) nanocomposites. The nanocomposites were characterized with Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). A nearly lateral-monolayer arrangement of CHX-Cu was supposed for the intercalation. Release kinetics indicated that the release process satisfied a pseudo-second-order mode. The antibacterial results showed that the CHX-Cu/MMT composites had long-term and controlled-release behavior.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China; Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. Electronic address: zhouninglin@njnu.edu.cn.
authors.forename: Ninglin
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gu
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Yunting
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China; Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China; Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. Electronic address: bioalchem@yahoo.com.
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001546:Bentonite / Q000737:chemistry*; D002710:Chlorhexidine / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D001546:Bentonite; D003300:Copper; D002710:Chlorhexidine