title: The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of dexmedetomidine (100 µg/kg-ip) on liver ischemia and reperfusion (I/R) in rats.
  
  
  METHODS
  Twenty-four Wistar Albino rats were separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 minutes and reperfusion period was 45 minutes after declampage. Group I/R-D was received dexmedetomidine 100 µg/kg i.p. 30 min before portal clampage. Thiobarbutiric Acid-Reactive Substances (TBARS), glutathioneS-transferase (GST), superoxide dismutase (SOD), Catalase (CAT), and Paraoxonase 1 (PON-1) were investigated in blood samples. Also HSP60 and p53-positive hepatocytes were counted under ImageJ image analysis program.
  
  
  RESULTS
  All parameters, except GST levels, were significant between the groups (p < 0.05). Although HSP60 expression was significantly increased between I/R, I/R-D and C groups there were no significant differences between I/R-D and C (p = 0.443). On the other hand, p53 expression was also significantly increased between I/R, I/R-D and C groups At the same time, there were no significant differences between I/R-D and C groups (p = 0.354).
  
  
  CONCLUSIONS
  All the results suggest that dexmedetomidine has beneficial effects on liver ischemia/reperfusion stress (Tab. 1, Fig. 2, Ref. 49).
authors.forename: A
authors.initials: A
authors.lastname: Kucuk
authors.forename: F
authors.initials: F
authors.lastname: Yaylak
authors.forename: A
authors.initials: A
authors.lastname: Cavunt-Bayraktar
authors.forename: M
authors.initials: M
authors.lastname: Tosun
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: F M
authors.initials: FM
authors.lastname: Comu
authors.forename: M
authors.initials: M
authors.lastname: Kavutcu
mesh_terms: D000818:Animals; D020927:Dexmedetomidine / Q000494:pharmacology*; D007511:Ischemia / Q000188:drug therapy*; D019194:Ischemic Preconditioning / Q000379:methods; D008099:Liver / Q000098:blood supply*; D008107:Liver Diseases / Q000188:drug therapy* / Q000517:prevention & control; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D020011:Protective Agents; D020927:Dexmedetomidine