title: Outcome of microsurgical testicular sperm extraction in familial idiopathic nonobstructive azoospermia.
abstract: The aim of the study was to evaluate the sperm retrieval rate by microsurgical testicular sperm extraction (TESE) in familial idiopathic nonobstructive azoospermia (NOA). One hundred and nineteen patients with idiopathic NOA who underwent microsurgical TESE over the past 5 years were included. Patients were then divided into two groups; Group 'A' with familial idiopathic NOA (11 families with two brothers in each family, 22 patients) and Group 'B' with nonfamilial idiopathic NOA (97 patients). Clinical data as well as data of microsurgical TESE were recorded. In Group 'A', the sperm retrieval rate was 9.1% (2/22 patients) compared to 45.4% in Group 'B' (44/97 patients) (P ≤ 0.05). The two patients in Group 'A' with successful sperm retrieval belonged to one family. The histopathological diagnosis was the same in the brothers in each family. It can be concluded that the testicular sperm retrieval rate in familial idiopathic NOA is significantly lower than in nonfamilial idiopathic NOA.
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.|Andrology Department, Cairo University Medical School, Cairo, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Arafa
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: H T
authors.initials: HT
authors.lastname: ElBardisi
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: S S
authors.initials: SS
authors.lastname: AlSaid
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: A
authors.initials: A
authors.lastname: Majzoub
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: A H
authors.initials: AH
authors.lastname: AlMalki
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: I
authors.initials: I
authors.lastname: ElRobi
authors.affiliation: Urology Department, Hamad Medical Corporation, Doha, Qatar.
authors.forename: A A
authors.initials: AA
authors.lastname: AlAnsari
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009845:Oligospermia / Q000473:pathology; D012189:Retrospective Studies; D012708:Sertoli Cells / Q000473:pathology; D035781:Siblings; D013079:Sperm Maturation; D053625:Sperm Retrieval; D013087:Spermatids / Q000473:pathology; D013094:Spermatozoa; D013737:Testis / Q000473:pathology*
keywords: Familial; intracytoplasmic sperm injection; nonobstructive azoospermia; testicular sperm extraction