title: NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection.
abstract: Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
authors.affiliation: Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Anselmo Jiro
authors.initials: AJ
authors.lastname: Kamada
authors.affiliation: Laboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pontillo
authors.affiliation: Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Rafael Lima
authors.initials: RL
authors.lastname: Guimarães
authors.affiliation: Fundação de Hematologia e Hemoterapia de Pernambuco, Recife, PE, Brasil.
authors.forename: Paula
authors.initials: P
authors.lastname: Loureiro
authors.affiliation: Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
authors.affiliation: Departamento de Patologia, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Lucas André Cavalcanti
authors.initials: LA
authors.lastname: Brandão
mesh_terms: D000328:Adult; D001938:Brazil; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D015490:HTLV-I Infections / Q000235:genetics / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D065840:Protective Factors
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D007375:Interleukin-1; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human