title: Trace analysis of N-acetyl-L-cysteine using luminol-H2O2 chemiluminescence system catalyzed by silver nanoparticles.
abstract: N-Acetyl-L-cysteine (NAC) can inhibit the luminol-H2 O2 , reaction, which is catalyzed by silver nanoparticles. Based on this phenomenon a new method was developed for NAC determination. Under optimum conditions, a linear relationship between chemiluminescence intensity and NAC concentration was found in the range 0.034-0.98 µg/mL. The detection limit was 0.010 µg/mL (S/N =3), and the relative standard deviation (RSD) was <5% for 0.480 µg/mL NAC (n =5). This simple, sensitive and inexpensive method has been applied to measure the concentration of NAC in pharmaceutical tablets.
authors.affiliation: Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
authors.forename: Abdolraouf
authors.initials: A
authors.lastname: Samadi-Maybodi
authors.affiliation: Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Akhoondi
mesh_terms: D000111:Acetylcysteine / Q000032:analysis*; D002384:Catalysis; D006861:Hydrogen Peroxide / Q000737:chemistry; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000379:methods*; D008165:Luminol / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013607:Tablets / Q000032:analysis* / Q000737:chemistry
chemical_list: D013607:Tablets; D012834:Silver; D008165:Luminol; D006861:Hydrogen Peroxide; D000111:Acetylcysteine
keywords: N-acetyl-L-cysteine; chemiluminescence; luminol; pharmaceutical tablet; silver nanoparticles