title: Proteomics of hosts and pathogens in cystic fibrosis.
abstract: Cystic fibrosis (CF) is a congenital disease that results in great morbidity and mortality mainly in the Caucasian population. Although CF is a monogenic disease caused by mutation in the CF conductance transmembrane regulator (CFTR) gene, most of the related mortality can be attributed to infection mediated by opportunistic bacterial and fungal pathogens. Over the past decade, advancements in the field of proteomics have helped to gain insight into the repertoire of host and pathogen proteins involved in CF pathophysiology. This review provides an overview of the contributions of proteomic studies in advancing our knowledge of the biology of CF and disease progression associated with pathogen infection and host defense responses.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia.
authors.forename: Karthik Shantharam
authors.initials: KS
authors.lastname: Kamath
authors.forename: Sheemal Shanista
authors.initials: SS
authors.lastname: Kumar
authors.forename: Jashanpreet
authors.initials: J
authors.lastname: Kaur
authors.forename: Vignesh
authors.initials: V
authors.lastname: Venkatakrishnan
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: Helena
authors.initials: H
authors.lastname: Nevalainen
authors.forename: Mark P
authors.initials: MP
authors.lastname: Molloy
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000378:metabolism* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: CFTR mutation; Cystic fibrosis; Infection; Inflammation