title: Asymmetric Synthesis of Hydroxy Esters with Multiple Stereocenters via a Chiral Phosphoric Acid Catalyzed Kinetic Resolution.
abstract: The kinetic resolution of hydroxy tert-butyl esters through a Brønsted acid catalyzed lactonization is described. The resulting enantioenriched molecules have cyclic backbones and/or multiple stereocenters. DFT calculations explore how small changes in substrate structure can have a large impact on the selectivity of the process.
authors.affiliation: †Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
authors.forename: Ghassan
authors.initials: G
authors.lastname: Qabaja
authors.affiliation: †Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Benavides
authors.affiliation: ‡Research Computing Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3420, United States.
authors.forename: Shubin
authors.initials: S
authors.lastname: Liu
authors.affiliation: †Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Petersen