title: Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti.
abstract: The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 μM). The best result in the series was obtained with the addition of verapamil (40 μM), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.
authors.affiliation: Faculdade de Medicina, Universidade Federal do Cariri, Barbalha, CE, Brasil.
authors.forename: Estelita Pereira
authors.initials: EP
authors.lastname: Lima
authors.affiliation: Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brasil.
authors.forename: Marília Oliveira Fonseca
authors.initials: MO
authors.lastname: Goulart
authors.affiliation: Faculdade de Medicina, Universidade Federal do Cariri, Barbalha, CE, Brasil.
authors.forename: Modesto Leite
authors.initials: ML
authors.lastname: Rolim Neto
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000187:drug effects / Q000502:physiology*; D000330:Aedes / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000494:pharmacology; D007303:Insect Vectors / Q000187:drug effects* / Q000378:metabolism; D007305:Insecticide Resistance / Q000187:drug effects; D007306:Insecticides / Q000493:pharmacokinetics / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D007928:Lethal Dose 50; D000002:Temefos / Q000493:pharmacokinetics / Q000494:pharmacology*; D014700:Verapamil / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D018528:ATP-Binding Cassette Transporters; D002121:Calcium Channel Blockers; D007306:Insecticides; D014700:Verapamil; D000002:Temefos