title: Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru.
abstract: OBJECTIVE
  To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.
  
  
  METHODS
  We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.
  
  
  RESULTS
  Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.
  
  
  CONCLUSIONS
  Start of and switching to MDR TB treatment is still delayed.
authors.affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru; Unit of General Epidemiology and Disease Control, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Otero
authors.forename: A
authors.initials: A
authors.lastname: De Orbegoso
authors.forename: A F
authors.initials: AF
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Ríos
authors.forename: T
authors.initials: T
authors.lastname: Párraga
authors.forename: E
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: C
authors.initials: C
authors.lastname: Seas
authors.forename: P
authors.initials: P
authors.lastname: Van der Stuyft
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D057915:Drug Substitution / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D017063:Outcome Assessment, Health Care; D010568:Peru / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents
keywords: Peru; Perú; Pérou; Tiempo hasta el inicio del tratamiento; Tuberculosis; multidrug resistant; multirresistente; multirésistante; temps jusqu'au traitement; time to treatment; tuberculose; tuberculosis