title: In vitro antitumor assessments of peptide nanocomplexes on Dalton's lymphoma ascites tumor model.
abstract: This research work reports the in vitro antitumor personality of few novel peptide nanocomplexes synthesized via a phase-assisted, modified Brust-Schiffrin methodology. Here, a series of metallo(copper, cobalt, nickel and zinc) nanocomplexes engineered with a pre-prepared peptide [N,N'-(1,2-ethylene)-bis-hippuricamide] have been synthesized for damaging the Dalton's lymphoma ascites tumor model. All the peptide nanocomplexes are spectrally, thermally and morphologically examined. The peptide bound zinc and cobalt nanocomplexes deliver excellent antitumor behavior against both the animal and human cancer cell lines, which has been pre-documented by their efficient DNA damaging skills under physiological conditions. Additionally, all the nanocomplexes are evaluated for the inhibition of microbial augmentation against few fungal and bacterial strains. The above results demonstrate that, a consecutive development of these kinds of peptide nanocomplexes may exemplify their uniqueness in biomedical applications as useful molecular-level devices.
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar, 626 001, India.
authors.forename: S
authors.initials: S
authors.lastname: Sudharsan
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar, 626 001, India. Electronic address: drn_raman@yahoo.co.in.
authors.forename: N
authors.initials: N
authors.lastname: Raman
authors.affiliation: Department of Pharmaceutical Chemistry, Swami Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu, 637 205, India.
authors.forename: R
authors.initials: R
authors.lastname: Senthilkumar
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001201:Ascites; D001419:Bacteria / Q000187:drug effects; D001709:Biotechnology; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology; D053761:Nanocomposites / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D019216:Metals, Heavy; D010455:Peptides