title: Perinatal infection and hypoxic-ischemic encephalopathy: a pilot study.
abstract: Recent studies suggest a synergic effect of infection and hypoxia-ischemia in the causation of perinatal brain damage. We conducted a prospective pilot study on the presence of infection in hypoxic-ischemic encephalopathy (HIE), focusing on neurotropic viruses. Sixteen newborns with HIE were included in the study. There were no confirmed cases of viral infection. There was a case of bacterial early onset sepsis and four cases of suspected sepsis due to clinical and/or analytical signs, but with negative cultures. Our results do not support universal screening for viral infection in cases of HIE.
authors.affiliation: a Department of Pediatrics .
authors.forename: Amaia
authors.initials: A
authors.lastname: Cilla
authors.affiliation: b Department of Neonatology , and.
authors.forename: Juan
authors.initials: J
authors.lastname: Arnaez
authors.affiliation: b Department of Neonatology , and.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Suarez
authors.affiliation: c Department of Microbiology , Burgos University Hospital , Burgos , Spain .
authors.forename: Gregoria
authors.initials: G
authors.lastname: Megias
authors.affiliation: d National Centre of Microbiology, Instituto de Salud Carlos III , Madrid , Spain , and.
authors.forename: María
authors.initials: M
authors.lastname: Cabrerizo
authors.affiliation: e Department of Neonatology , Hospital Sant Joan de Deu , Barcelona , Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Garcia-Alix
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000382:microbiology*; D007231:Infant, Newborn; D007239:Infections / Q000150:complications*; D008297:Male; D010865:Pilot Projects; D011247:Pregnancy; D011446:Prospective Studies
keywords: Asphyxia; C reactive protein; infection; neurological damage; newborn; virus