title: Clinical significance of cyclophilin a expression in esophageal squamous cell carcinoma.
abstract: OBJECTIVE
  To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance.
  
  
  METHODS
  Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed.
  
  
  RESULTS
  There were 166 patients with high expression of CypA (70.23%) and a higher expression in 69.3% of males and 73.3% in females. The CypA expression was irrelevant to age, tumor location, lymph node metastasis, and tumor differentiation degree. The Kaplan-Meier survival curve analysis showed that the expression of CypA was associated with the prognosis of patients with esophageal squamous cell carcinoma.
  
  
  CONCLUSIONS
  The poor prognosis of esophageal cancer patients was associated with high expression of CypA.
authors.affiliation: 1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China .
authors.forename: Ming-Xiang
authors.initials: MX
authors.lastname: Feng
authors.forename: Jing-Pei
authors.initials: JP
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Ya-Xing
authors.initials: YX
authors.lastname: Shen
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Tan
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Wang
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000401:mortality / Q000473:pathology; D021984:Cyclophilin A / Q000096:biosynthesis*; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000401:mortality / Q000473:pathology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: D009363:Neoplasm Proteins; D021984:Cyclophilin A