title: New triterpenoid saponins from the aerial parts of Comastomapedunculatum.
abstract: Three new saikosaponin analogs, comastomasaponins I-K (1-3), were isolated from the aerial portions of Comastomapedunculatum. The structures of these compounds were elucidated on the basis of spectroscopic data analysis, and their nitric oxide production inhibitory activity was evaluated invitro.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yong-Qi
authors.initials: YQ
authors.lastname: Qiao
authors.forename: Bao-Song
authors.initials: BS
authors.lastname: Cui
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Yuan
authors.forename: Qi
authors.initials: Q
authors.lastname: Hou
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
mesh_terms: D027481:Araliaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D035261:Plant Components, Aerial / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; C000598442:comastomasaponin I; C000598443:comastomasaponin J; C000598444:comastomasaponin K; D009569:Nitric Oxide; D009828:Oleanolic Acid; C025759:saikosaponin D
keywords: Comastomapedunculatum; Gentianaceae; NO production inhibition; saikosaponin analogs; structure elucidation