title: [Seasonal features influence opioid receptor blockers on adaptive behavior of hibernating animals].
abstract: The research of the effect of blockade of opioid receptors of the brain in Yakut hibernating ground squirrels (n = 42) by naloxone was performed on animal behavior in the open field and in the hole board during the autumn--period of preparation to hibernation and in spring after arousal (or after the hibernating bout). It is shown that the inhibitory effects of the blockade of opioid receptor on the system parameters total level of activation of the CNS of ground squirrels are more pronounced in autumn than in spring. The results of the biochemical analysis of the levels of monoamines demonstrated a difference in the ratio of noradrenaline/serotonin in the brain of animals in the spring and autumn periods. It is assumed that the interaction of opioid and monoaminergic systems allows, among other factors, to translate homeostasis of hibernating animals on the new level, which necessary for preparation for hibernation in the autumn, as well as, for transition to the active homoiothermic state in the spring.
authors.forename: T P
authors.initials: TP
authors.lastname: Semenova
authors.forename: N M
authors.initials: NM
authors.lastname: Zakharina
mesh_terms: D000818:Animals; D006605:Hibernation / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000493:pharmacokinetics*; D009638:Norepinephrine / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D012589:Sciuridae; D012621:Seasons; D012701:Serotonin / Q000378:metabolism*
chemical_list: D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D012701:Serotonin; D009270:Naloxone; D009638:Norepinephrine