title: Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy.
abstract: This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.
authors.affiliation: a Laboratory for AIDS Vaccine Research & Development; Department of Surgery; Duke University Medical Center; Durham, NC USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Montefiori
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D057134:Antibodies, Neutralizing / Q000097:blood*; D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research / Q000379:methods; D015483:HIV Antibodies / Q000097:blood*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D015415:Biomarkers; D015483:HIV Antibodies
keywords: HIV; correlates; neutralizing antibodies; sieve; vaccines