title: Bevacizumab maintenance in metastatic colorectal cancer: How long?
abstract: The management of patients with non-progressive metastatic colorectal cancer after six months of treatment has not yet been codified. The most relevant concerns are the effectiveness of maintenance vs discontinuation, and the tolerability of prolonged treatment. Here we report the case of a 72-year-old man affected by colorectal cancer with lung metastases who achieved a complete response after receiving capecitabine, oxaliplatin and bevacizumab for six months, and bevacizumab alone for six months. Bevacizumab was continued as maintenance regimen for more than three years. It was discontinued because of an arthroplasty. Fifty-eight months after beginning first-line treatment, the patient remains free from relapse. Adverse effects were minimal and easily controlled.
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: De Stefano
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Moretto
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Chiara Alessandra
authors.initials: CA
authors.lastname: Cella
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Francesco Jacopo
authors.initials: FJ
authors.lastname: Romano
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Raimondo
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fiore
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Di Pietro
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pepe
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Sabino
authors.initials: S
authors.lastname: De Placido
authors.affiliation: Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Carlomagno
keywords: Bevacizumab; Maintenance; Metastatic colorectal cancer