title: Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine.
abstract: An efficient and straightforward method for the production of 5-(3-indolyl)azoles incorporating the privileged structures indoles and azoles via palladium-catalyzed double C-H bond cleavage under mild conditions was disclosed. As expected, this protocol provided an easy method for the synthesis of indole alkaloids pimprinine and WS-30581 A in moderate yields.
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China. xmwu@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Haipin
authors.initials: H
authors.lastname: Zhou
authors.forename: Kuo
authors.initials: K
authors.lastname: Gai
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
mesh_terms: D001393:Azoles / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001393:Azoles; D002264:Carboxylic Acids; D007211:Indoles; D010080:Oxazoles; C008912:pimprinine; D010165:Palladium