title: The role of VEGF in the diabetic patients undergoing endovascular therapy of symptomatic aortic valve stenosis.
abstract: The aim of this study was to explore changes in plasma vascular endothelial growth factor (VEGF) in aged patients who undergone transcatheter aortic valve implantation or balloon angioplasty for the treatment of aortic stenosis. Plasma VEGF was measured in subjects with diabetes mellitus type 2 (DM) (n=21, age 79.2+/-1.6 years) and in non-diabetic subjects (non-DM) (n=23, age 84.4+/-0.7 years), using an ELISA kit. Before the procedure plasma levels of VEGF were significantly lower in DM than in non-DM patients (P<0.05). Plasma VEGF significantly increased in both groups (DM and non-DM) 24 h (387+/-64 vs. 440+/-30 pg/ml, P<0.05) and 72 h (323+/-69 vs. 489+/-47 pg/ml, P<0.05) after the endovascular procedure. However, the VEGF in DM patients was significantly lower compared to non-DM subjects up to one month after the endovascular procedure (283+/-47 vs. 386+/-38 pg/ml, P<0.05). We conclude that increased plasma VEGF in aged patients associates with atherosclerotic aortic valve stenosis. In spite of that plasma VEGF in DM was constantly significantly lower than in non diabetic patients, both before and after the endovascular procedure, possibly reflecting a disturbance of angiogenic/anti-angiogenic balance in diabetes.
authors.affiliation: Third Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové and Medical Faculty Charles University in Hradec Králové, Hradec Králové, Czech Republic. blaha@lfhk.cuni.cz.
authors.forename: V
authors.initials: V
authors.lastname: Bláha
authors.forename: J
authors.initials: J
authors.lastname: Šťásek
authors.forename: J
authors.initials: J
authors.lastname: Bis
authors.forename: J
authors.initials: J
authors.lastname: Fortunato
authors.forename: C
authors.initials: C
authors.lastname: Andrýs
authors.forename: V
authors.initials: V
authors.lastname: Pavlík
authors.forename: P
authors.initials: P
authors.lastname: Polanský
authors.forename: M
authors.initials: M
authors.lastname: Brtko
authors.forename: L
authors.initials: L
authors.lastname: Sobotka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D057510:Endovascular Procedures / Q000639:trends; D005260:Female; D006801:Humans; D008297:Male; D011182:Postoperative Care / Q000639:trends; D065467:Transcatheter Aortic Valve Replacement / Q000639:trends; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A