title: [Changes of circulating hematopoietic progenitor cells in patients undergoing coronary artery bypass graft surgery].
abstract: OBJECTIVE
  To evaluate the changes of circulating hematopoietic progenitor cells (cHPCs) in patients undergoing coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Fifty-one patients scheduled to undergo elective CABG surgery were prospectively enrolled in this study. Blood samples were collected at baseline and at 1, 3, and 5 days after the surgery. CD34⁺ CD45dim, CD133⁺ CD45dim, and CD34⁺ CD133⁺ CD45dim cells were measured by flow cytometry. The functionality of the circulating progenitor cells were studied in vitro using clonogenic and migration assays.
  
  
  RESULTS
  All the elective patients showed a significant postoperative increase of CD34⁺ CD45dim (1.51 ± 1.26 vs 2.02 ± 1.16, P=0.036) and CD133⁺ CD45dim cells (1.16 ± 0.85 vs 1.65 ± 0.99, P=0.008) irrespective of on-pump or off-pump CABG. The perioperative changes of the cHPCs was more significant in patients undergoing on-pump surgery than those having off-pump surgery.
  
  
  CONCLUSIONS
  In patients undergoing elective cardiac surgery, cHPC level increased early after the surgery but recovers the normal level over time.
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of PLA, Iinstitute of Cardiac Surgery of PLA, Beijing 100853, China. E-mail: drzhanglin@gmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Changqing
authors.initials: C
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Cangsong
authors.initials: C
authors.lastname: Xiao
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
mesh_terms: D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D011184:Postoperative Period