title: Association of Dowling-Degos disease and multiple seborrheic keratosis in a "Christmas tree pattern".
abstract: Dowling-Degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. This entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. We report the sporadic form of Dowling-Degos disease in an elderly man with multiple seborrheic keratosis in a "Christmas tree" pattern. Worthy of note in this case study is the lesions evolved for over than 30 years. The aim is to describe the association of these keratoses with Dowling-Degos disease in a healthy man.
authors.affiliation: 1. MD, PhD. Internal Medicine Department of Armed Forces Hospital (HFA) and Catholic University (UCB), Brasília- DF, Brazil. vitorinomodesto@gmail.com.
authors.forename: Vitorino Modesto
authors.initials: VM
authors.lastname: Dos Santos
authors.affiliation: 2. Medical Intern of UCB. nanalays@hotmail.com.
authors.forename: Nayanne Lays Dos Santos
authors.initials: NL
authors.lastname: Pereira
authors.affiliation: 3. Medical Intern of UCB. rezynha82@hotmail.com.
authors.forename: Renata Faria
authors.initials: RF
authors.lastname: Silva
authors.affiliation: 4. MD, Internal Medicine Department of HFA. fabiohenrique_81@yahoo.com .br.
authors.forename: Fabio Henrique de Oliveira
authors.initials: FH
authors.lastname: Silva
authors.affiliation: 5. MD, MSc. Pathology Division of HFA. cacildaroberto@msn.com.
authors.forename: Cacilda Joyce Ferreira da Silva
authors.initials: CJ
authors.lastname: Garcia
authors.affiliation: 6. MD, Dermatology Division of HFA. dramariaalves@gmail.com.
authors.forename: Maria Aparecida Alves de Figueiredo
authors.initials: MA
authors.lastname: Sousa
keywords: Dowling-Degos disease; Reticular pigment anomaly of flexures; Seborrheic keratosis