title: Reflectance spectroscopy for noninvasive evaluation of hair follicle stage.
abstract: Hair follicle offers an excellent model for systems biology and regenerative medicine. So far, the stages of hair follicle growth have been evaluated by histological examination. In this work, a noninvasive spectroscopy was proposed by measuring the diffuse reflectance of mouse skin and analyzing the melanin value. Results show that the skin diffuse reflectance was relatively high when hair follicles were at the telogen stage and at the beginning of the anagen stage, and decreased with the progression of the anagen stage. When the hair follicle entered into the catagen stage, the diffuse reflectance gradually increased. The changes in the melanin content of skin had contrary dynamics. Substages of the hair follicle cycle could be distinguished by comparing the changes in melanin value with the histological examination. This study provided a new method for noninvasive evaluation of the hair follicle stage, and should be valuable for basic and therapeutic investigations on hair regeneration.
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Caihua
authors.initials: C
authors.lastname: Liu
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Yue
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Jianru
authors.initials: J
authors.lastname: Wang
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Xiewei
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Liu
authors.affiliation: Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037# Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Eng.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000818:Animals; D005260:Female; D006197:Hair / Q000254:growth & development*; D018859:Hair Follicle / Q000254:growth & development / Q000502:physiology*; D008543:Melanins / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D055095:Optics and Photonics; D012038:Regeneration; D012867:Skin / Q000378:metabolism; D012880:Skin Pigmentation; D013053:Spectrophotometry / Q000379:methods*
chemical_list: D008543:Melanins