title: Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of a chemical plant in Tianjin: a primary study.
abstract: Several studies have suggested that maternal exposure to Polychlorinated dibenzo-p-dioxins (PCDDs), poly-chlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs) may affect foetal growth and infant development. The aim of our study was to determine whether the childbearing-aged residents living near a chemical plant have a greater exposure risk. Concentrations of 17 PCDD/Fs congeners and 12 non-ortho and mono-ortho dioxin-like PCBs were measured using HRGC-HRMS in the blood of 30 non-occupational childbearing-aged women living near a chemical plant (Dagu) that had been producing chlorinated pesticides from 1958 to 2004. The factors that influenced the body burden were investigated based on responses to a questionnaire. Levels of PCDD/Fs+PCBs were in the range of 16.43-155.29pg WHO 2005-TEQg(-1) lipid. PCDDs and PCDFs contributed 56.72% and 34.44%, respectively, to the total TEQ value. Total WHO-TEQ was approximately tenfold higher in the participants living in the vicinity of the plant (distance: 1.52±0.148km) than in the groups living farther away (distance: 4.93±1.124km). A negative correlation between total WHO-TEQ and distance to Dagu was observed by multiple linear regression models. The data provide basic information for monitoring dioxin-like chemicals in the district and for the future study of the relationship between POPs and pregnancy outcomes.
authors.affiliation: Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China.
authors.forename: Jing-shan
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Key Lab for Food Safety and Risk Assessment, Ministry of Public Health & China Center for Food Safety Risk Assessment, 7 Panjiayuan Nan Li, Chao Yang District, Beijing 100021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Lab for Food Safety and Risk Assessment, Ministry of Public Health & China Center for Food Safety Risk Assessment, 7 Panjiayuan Nan Li, Chao Yang District, Beijing 100021, China.
authors.forename: Jing-guang
authors.initials: JG
authors.lastname: Li
authors.affiliation: Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
authors.forename: Lena
authors.initials: L
authors.lastname: Yao
authors.affiliation: Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Self
authors.affiliation: Key Lab of Chemical Safety and Health, Chinese Center for Disease Control and Prevention & National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 27 Nan Wei Road, West City District, Beijing 100050, China. Electronic address: sunxin@chinacdc.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China. Electronic address: tangnaijun@tijmu.edu.cn.
authors.forename: Nai-jun
authors.initials: NJ
authors.lastname: Tang
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000097:blood*; D001822:Body Burden; D002681:China; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000097:blood*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D018811:Maternal Exposure; D015999:Multivariate Analysis; D010865:Pilot Projects; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011247:Pregnancy; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
keywords: Chemical Plant; Childbearing-aged Women; Dioxins; PCDDs; PCDFs; dl-PCBs