title: Vitamin B6 supplementation improves oxidative stress and enhances serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats.
abstract: The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P < 0.01) and D + Vit B6 (P < 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P < 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.
authors.affiliation: Department of Biology, Science and Literature Faculty, Uludağ University, 16059 Bursa, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Taş
authors.affiliation: Department of Biochemistry, Medical Faculty, Uludağ University, 16059 Bursa, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandöl
authors.affiliation: Department of Biochemistry, Medical Faculty, Uludağ University, 16059 Bursa, Turkey.
authors.forename: Melahat
authors.identifier: 0000-0002-4956-5278
authors.initials: M
authors.lastname: Dirican
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000517:prevention & control; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D004334:Drug Administration Schedule; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D025101:Vitamin B 6 / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D013311:Streptozocin; D025101:Vitamin B 6; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase