title: Relationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers.
abstract: OBJECTIVE
  To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) in cervical cancer perfusion.
  
  
  METHODS
  Prospective newly diagnosed cervical cancer patients underwent diffusion-weighted MRI (13 b-values: 1-1000 s/mm(2) ) and DCE-MRI. The IVIM perfusion parameters, perfusion fraction (f), pseudodiffusion coefficient (D*), and flow-related parameter (fD*), were derived from a biexponential decay model. DCE-MRI was analyzed with a pharmacokinetic model and signal-time curve to derive the amplitude factor (A), estimated volume transfer constant between blood plasma, and the extravascular extracellular space (est K(trans) ), maximum relative enhancement (MaxRE), and area under the signal-time curve (AUC). Spearman's rank correlation coefficient (r) evaluated the correlative relationships.
  
  
  RESULTS
  The f = 13.51% ± 1.76%, D* = 71.72 ± 7.55 × 10(-3) mm(2) /s, fD* = 9.64 ± 1.28 × 10(-3) mm(2) /s, A = 1.41 ± 0.43, est K(trans) = 0.19 ± 0.06 s(-1) , MaxRE of 120.02 ± 21.07%, and AUC 212,393 ± 54,423 was found in 25 cervical cancer patients. Statistically significant positive correlations were found between fD* and est K(trans) (r = 0.42, P = 0.038), fD* and A (r = 0.50, P = 0.011), fD* and MaxRE (r = 0.52, P = 0.008), f and AUC (r = 0.58, P = 0.003).
  
  
  CONCLUSIONS
  The IVIM perfusion parameters showed moderate to good correlations with quantitative and semiquantitative perfusion parameters derived from DCE-MRI in cervical cancer.
authors.affiliation: Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Elaine Yuen Phin
authors.initials: EY
authors.lastname: Lee
authors.affiliation: Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Edward Sai Kam
authors.initials: ES
authors.lastname: Hui
authors.affiliation: Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Karen Kar Loen
authors.initials: KK
authors.lastname: Chan
authors.affiliation: Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Ka Yu
authors.initials: KY
authors.lastname: Tse
authors.affiliation: Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
authors.forename: Wai Kay
authors.initials: WK
authors.lastname: Kwong
authors.affiliation: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
authors.forename: Tien Yee
authors.initials: TY
authors.lastname: Chang
authors.affiliation: Philips Healthcare, Hong Kong, China.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Chan
authors.affiliation: Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Pek-Lan
authors.initials: PL
authors.lastname: Khong
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008536:Meglumine; D008875:Middle Aged; D009038:Motion; D009942:Organometallic Compounds; D055420:Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
keywords: DCE-MRI; IVIM; cervical cancer; intravoxel incoherent motion; perfusion