title: Chronic elevation of systemic glucagon-like peptide-1 following surgical weight loss: association with nausea and vomiting and effects on adipokines.
abstract: We determined whether persistent nausea and vomiting (N/V) symptoms following Roux-en-Y gastric bypass surgery is due to elevated systemic glucagon-like peptide-1 (GLP-1) and leptin in female non-diabetic subjects. Subjects with N/V post-Roux-en-Y gastric bypass (RYGB) surgery had significantly elevated fasting GLP-1 levels compared to that with post-operative asymptomatic subjects and to morbidly obese, obese and lean subjects not undergoing surgery. Weight loss, glycaemia, insulin and post-prandial GLP-1 levels were similar in all post-operative subjects. Despite comparable BMI, leptin was significantly lower in symptomatic subjects. Furthermore, leptin secretion from subcutaneous adipose tissue was inhibited by GLP-1 (0.1-1.0 nM; n = 6). Persistent N/V following RYGB surgery is associated with elevated fasting GLP-1, but lower leptin levels. The latter may be a consequence of the direct GLP-1 inhibition of leptin secretion from adipose tissue.
authors.affiliation: Adipokines & Metabolism Research Group, Centre for Clinical Pharmacology, Division of Medicine, University College London, 5 University St., London, WC1E 6JJ, UK.
authors.forename: Noora
authors.initials: N
authors.lastname: Al-Rasheid
authors.forename: Rosaire
authors.initials: R
authors.lastname: Gray
authors.forename: Pratik
authors.initials: P
authors.lastname: Sufi
authors.forename: Nephtali
authors.initials: N
authors.lastname: Marina-Gonzalez
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Sayrafi
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Atherton
authors.forename: Vidya
authors.initials: V
authors.lastname: Mohamed-Ali
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D015390:Gastric Bypass / Q000009:adverse effects; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009325:Nausea / Q000097:blood* / Q000209:etiology; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D020250:Postoperative Nausea and Vomiting / Q000097:blood* / Q000209:etiology; D019518:Postprandial Period; D014839:Vomiting / Q000097:blood* / Q000209:etiology; D015431:Weight Loss / Q000502:physiology*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D052216:Glucagon-Like Peptide 1