title: Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes.
abstract: Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2]nonanes. Structure verification was done by NMR measurements. The new compounds were tested for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K 1 (multiresistant) and Trypanosoma brucei rhodesiense as well as for their cytotoxicity against L6 cells. Their activities are compared to those of already prepared compounds and structure-activity relationships are discussed.
authors.affiliation: Center for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan.
authors.forename: Sarfraz
authors.initials: S
authors.lastname: Ahmad
authors.forename: Werner
authors.initials: W
authors.lastname: Seebacher
authors.forename: Volker
authors.initials: V
authors.lastname: Wolkinger
authors.forename: Armin
authors.initials: A
authors.lastname: Presser
authors.forename: Johanna
authors.initials: J
authors.lastname: Faist
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Robert
authors.initials: R
authors.lastname: Saf
authors.forename: Robert
authors.initials: R
authors.lastname: Weis
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000502:physiology; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects* / Q000502:physiology
chemical_list: D000473:Alkanes; D000981:Antiprotozoal Agents; D053961:Azabicyclo Compounds; C017573:nonane