title: Cutaneous leiomyosarcoma - Case report.
abstract: Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. CLM presents in persons of all ages but with a peak between 60-70 years old. It may also occur anywhere on the body; the existing cases reported it on the face and trunk. The clinic of leiomyosarcoma consists in a firm dermal nodule, which can be painful, pruritic or paresthestic. The tumor is of 1-3 cm in diameter and can often be seen as a solitary formation. We report one case of a cutaneous leiomyosarcoma arising in the chest region of a 79- year-old male. Leiomyosarcoma is a rare entity whose clinical presentation may appear nonspecific, making diagnosis difficult. Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method. Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits. Despite the claims of radical surgical treatment, due to recurrence rates, the prognosis remains poor. We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy.
authors.forename: M E
authors.initials: ME
authors.lastname: Ciurea
authors.affiliation: Department of Histopathology, County Emergency Hospital, Craiova.
authors.forename: C V
authors.initials: CV
authors.lastname: Georgescu
authors.affiliation: Department of Dermatology, Craiova University of Medicine and Pharmacy.
authors.forename: C C
authors.initials: CC
authors.lastname: Radu
authors.affiliation: Department of Pharmacology, Craiova University of Medicine and Pharmacy; Department of Anesthesiology and Intensive Care, County Emergency Hospital, Craiova.
authors.forename: C C
authors.initials: CC
authors.lastname: Georgescu
authors.affiliation: Department of Dermatology, Craiova University of Medicine and Pharmacy.
authors.forename: L E
authors.initials: LE
authors.lastname: Stoica
mesh_terms: D000368:Aged; D006652:Histological Techniques; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D008297:Male; D011379:Prognosis; D012383:Romania; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D014746:Vimentin
chemical_list: D014746:Vimentin
keywords: leiomyosarcoma; pleomorphic; skin