title: Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy.
abstract: This chapter outlines: (1) the reasons why epidemiologic surveys and randomized controlled clinical trials (RCTs) of diabetic polyneuropathy (DPN) are difficult and expensive, and often poorly done, (2) primary and secondary neuropathy end points, (3) single versus composite neuropathic end points, (4) adequate reference values from study of population representative cohorts, and (5) the issue of clinical proficiency.
authors.affiliation: Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address: dyck.peter@mayo.edu.
authors.forename: Peter James
authors.initials: PJ
authors.lastname: Dyck
mesh_terms: D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000453:epidemiology*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards; D011795:Surveys and Questionnaires / Q000592:standards
keywords: Polyneuropathy end points; randomized controlled clinical trials; standard reference values of neurophysiologic tests