title: Thymic hyperplasia following chemotherapy in adults with lymphoma: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography findings and correlation with T cell repopulation.
abstract: Thymic hyperplasia (TH) after chemotherapy is an infrequent phenomenon in adults. This study analyzed the incidence and metabolic activity of TH on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in this population. By reviewing 471 PET/CT recordings of 211 adults with lymphoma, increased FDG uptake within an enlarged thymus regarded as TH was observed in 27 patients aged 18-53 years. FDG uptake in hyperplastic thymus was mild and diffuse, with a maximum standard uptake value (SUVmax) of 2.6±0.9. Its intensity varied with different occurrence times following chemotherapy. In addition, by comparing the recovery of T cell subsets in patients with TH (n=20) and without TH (n=28), no impact of the presence of TH was found on the repopulation of total CD4+and CD8+T cells within the first year after treatment. These data may be helpful to avoid misinterpretation of increased thymic uptake in adults.
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.|b Department of Hematology , Shandong Jining No. 1 People's Hospital , Jining , China.
authors.forename: Dao-Ping
authors.initials: DP
authors.lastname: Sun
authors.affiliation: c Department of Nuclear Medicine , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Chong-Yang
authors.initials: CY
authors.lastname: Ding
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Liang
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Wu
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: c Department of Nuclear Medicine , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Tian-Nv
authors.initials: TN
authors.lastname: Li
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: a Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing , China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D016176:T-Lymphocyte Subsets / Q000378:metabolism / Q000473:pathology; D013952:Thymus Hyperplasia / Q000175:diagnosis* / Q000209:etiology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: PET/CT; Thymus; adult; chemotherapy; hyperplasia; lymphoma