title: [Modulating the survival and maturation system of B lymphocytes: Current and future new therapeutic strategies in systemic lupus erythematosus].
abstract: Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their survival and maturation, have contributed to the development of new therapeutic strategies in recent years.
authors.affiliation: Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: lvalor.hgugm@salud.madrid.org.
authors.forename: Lara
authors.initials: L
authors.lastname: Valor
authors.affiliation: Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: López-Longo
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D018951:Antigens, CD20 / Q000276:immunology; D053265:B-Cell Activation Factor Receptor / Q000037:antagonists & inhibitors / Q000276:immunology; D053301:B-Cell Maturation Antigen / Q000037:antagonists & inhibitors / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D002470:Cell Survival; D005544:Forecasting; D006801:Humans; D016130:Immunophenotyping; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D038041:Lymphopoiesis; D058990:Molecular Targeted Therapy; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000037:antagonists & inhibitors / Q000276:immunology; D053303:Transmembrane Activator and CAML Interactor Protein / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20; D053265:B-Cell Activation Factor Receptor; D053301:B-Cell Maturation Antigen; C497867:CD22 protein, human; D051918:Sialic Acid Binding Ig-like Lectin 2; C108467:TNFRSF13B protein, human; C435926:TNFRSF13C protein, human; C086966:TNFRSF17 protein, human; D053303:Transmembrane Activator and CAML Interactor Protein
keywords: B lymphocyte; B-cell activation factor; Biologic therapies; Linfocito B; Lupus eritematoso sistémico; Systemic lupus erythematosus; Tratamientos biológicos