title: Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles.
abstract: A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified "aptamer monomer" results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.
authors.affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poma
authors.forename: Heli
authors.initials: H
authors.lastname: Brahmbhatt
authors.forename: Hannah M
authors.initials: HM
authors.lastname: Pendergraff
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Watts
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Turner
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000235:genetics; D001483:Base Sequence; D008958:Models, Molecular; D008968:Molecular Conformation; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D052157:Aptamers, Nucleotide; D011108:Polymers
keywords: aptamers; cocaine; molecularly imprinted polymers; nanoparticles; solid-phase synthesis