title: Unusual progression and subsequent improvement in cystic lung disease in a child with radiation-induced lung injury.
abstract: Radiation-induced lung disease is a known complication of therapeutic lung irradiation, but the features have not been well described in children. We report the clinical, radiologic and histologic features of interstitial lung disease (ILD) in a 4-year-old child who had previously received lung irradiation as part of successful treatment for metastatic Wilms tumor. Her radiologic abnormalities and clinical symptoms developed in an indolent manner. Clinical improvement gradually occurred with corticosteroid therapy. However, the observed radiologic progression from interstitial and reticulonodular opacities to diffuse cystic lung disease, with subsequent improvement, is striking and has not been previously described in children.
authors.affiliation: Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolf
authors.forename: Ashley D
authors.initials: AD
authors.lastname: Chadha
authors.forename: Clinton M
authors.initials: CM
authors.lastname: Carroll
authors.forename: Scott C
authors.initials: SC
authors.lastname: Borinstein
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Young
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000150:complications* / Q000188:drug therapy*; D017564:Radiation Pneumonitis / Q000150:complications* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones