title: Evaluation of ανβ3-mediated tumor expression with a 99mTc-labeled ornithine-modified RGD derivative during glioblastoma growth in vivo.
abstract: In this study, a novel way of distinguishing the intrinsic relationship between ανβ3 integrin targeting and detection of tumor growth by using a radiolabeled tracer based on a cyclic Arg-Gly-Asp (RGD) peptide was provided. The potential of the in vivo scintigraphic imaging of the developing vasculature from the early stage of tumor growth was evaluated. Alongside with the scintigraphic images, biodistribution studies were performed at distinct time points to validate this noninvasive imaging approach. The ability to noninvasively assess the tumor growth of ανβ3 integrin-positive glioblastoma tumors provides a method to better understand tumor angiogenesis in vivo and allows for a direct assessment of anti-integrin treatment efficacy.
authors.affiliation: 1 Department of Medical Physics, School of Medicine, University of Patras , Rion, Greece .
authors.forename: Irene
authors.initials: I
authors.lastname: Tsiapa
authors.forename: George
authors.initials: G
authors.lastname: Loudos
authors.forename: Eirini A
authors.initials: EA
authors.lastname: Fragogeorgi
authors.forename: Penelope
authors.initials: P
authors.lastname: Bouziotis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Psimadas
authors.forename: Stavros
authors.initials: S
authors.lastname: Xanthopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Paravatou-Petsotas
authors.forename: Lazaros
authors.initials: L
authors.lastname: Palamaris
authors.forename: Alexandra D
authors.initials: AD
authors.lastname: Varvarigou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Karnabatidis
authors.forename: George C
authors.initials: GC
authors.lastname: Kagadis
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005909:Glioblastoma / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D016513:Mice, SCID; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D009842:Oligopeptides / Q000378:metabolism*; D009952:Ornithine / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000378:metabolism; D013667:Technetium / Q000008:administration & dosage* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D039302:Integrin alphaVbeta3; D009842:Oligopeptides; D019275:Radiopharmaceuticals; D013667:Technetium; C047981:arginyl-glycyl-aspartic acid; D009952:Ornithine
keywords: 99mTc; angiogenesis; cRGDfK; glioblastoma; scintigraphic imaging; tumor growth