title: Preparation and characterization of acrylic bone cement with high drug release.
abstract: Drug-loaded bone cement is used as an application method to prevent and treat prosthesis-related infection. Despite the commercial availability of drug-loaded bone cement, low release rate of drugs from drug-loaded bone cement may result in the emergence of drug-resistant coagulase-negative staphylococci in subsequent deep infection. This work presents a method to control and increase both the drug release rate and total release amounts of drugs for drug-loaded bone cement without losing the mechanical properties of cement. A novel drug-loaded bone cement is also developed by introducing cross-linked poly(methylmethacrylate-acrylic acid sodium salt) particles into bone cement. Capable of increasing the hydrophilicity of the cement and allowing fluids to pass into the cement, the bone cement developed here supplements both the drug release rate and total release amounts of drugs.
authors.affiliation: Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Douliou, Yunlin, 64002, Taiwan. Electronic address: nienyh@yuntech.edu.tw.
authors.forename: Yu-Hsun
authors.initials: YH
authors.lastname: Nien
authors.affiliation: Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Douliou, Yunlin, 64002, Taiwan.
authors.forename: Shi-wen
authors.initials: SW
authors.lastname: Lin
authors.affiliation: Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Douliou, Yunlin, 64002, Taiwan.
authors.forename: You-Ning
authors.initials: YN
authors.lastname: Hsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics; D001843:Bone Cements / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D007660:Ketoprofen / Q000737:chemistry / Q000493:pharmacokinetics; D008956:Models, Chemical; D019904:Polymethyl Methacrylate / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D019904:Polymethyl Methacrylate; D007660:Ketoprofen