title: Global displacement of canine parvovirus by a host-adapted variant: structural comparison between pandemic viruses with distinct host ranges.
abstract: Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
authors.affiliation: Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Lindsey J
authors.initials: LJ
authors.lastname: Organtini
authors.affiliation: Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Allison
authors.affiliation: Macromolecular Diffraction Facility at CHESS (MacCHESS), Cornell University, Ithaca, New York, USA.
authors.forename: Tiit
authors.initials: T
authors.lastname: Lukk
authors.affiliation: Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Parrish
authors.affiliation: Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA shafenstein@hmc.psu.edu.
authors.forename: Susan
authors.initials: S
authors.lastname: Hafenstein
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000737:chemistry; D018360:Crystallography, X-Ray; D004283:Dog Diseases / Q000453:epidemiology / Q000821:virology*; D004285:Dogs; D058507:Host Specificity; D008958:Models, Molecular; D050505:Mutant Proteins / Q000737:chemistry; D058873:Pandemics; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D011487:Protein Conformation
chemical_list: D036022:Capsid Proteins; D050505:Mutant Proteins