title: The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome.
abstract: The aim of this study was to quantify the sulfated glycosaminoglycans in the endometria of women with polycystic ovary syndrome (PCOS). Of the 18 patients recruited for this study, 10 patients with PCOS comprised the PCOS group (PCOSG), and eight patients with regular and ovulatory menstrual cycles comprised the control group (CG). The clinical, biochemical, morphological and endometrial data from both groups were analyzed. Biopsies were performed during the proliferative phase of the menstrual cycle for the CG and during the persistent proliferative phase for the PCOSG (all women were amenorrheic). In the PCOSG, there was a significant increase in the endometrial concentration levels of heparan sulfate (p = 0.03), but no difference in the concentrations of chondroitin sulfate was determined between the two groups (p = 0.77). Period of time without menstruation (p = 0.001) and body mass index (BMI) (p = 0.04) correlated directly and positively with heparan sulfate concentration. There was no association between heparan sulfate levels and basal insulin values (p = 0.08). High levels of endometrial heparan sulfate in women with PCOS indicate an interference with maternal-fetal recognition, which contributes to infertility; thus, endometrial heparan sulfate may be a predictive marker of future neoplasia risk.
authors.affiliation: Gynecology Department, Federal University of São Paulo , São Paulo , Brazil .
authors.forename: Mario Vicente
authors.initials: MV
authors.lastname: Giordano
authors.forename: Luiz Augusto
authors.initials: LA
authors.lastname: Giordano
authors.forename: Regina Célia Teixeira
authors.initials: RC
authors.lastname: Gomes
authors.forename: Ricardo Santos
authors.initials: RS
authors.lastname: Simões
authors.forename: Helena Bonciani
authors.initials: HB
authors.lastname: Nader
authors.forename: Mario Gáspare
authors.initials: MG
authors.lastname: Giordano
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
authors.forename: José Maria
authors.initials: JM
authors.lastname: Soares Júnior
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002809:Chondroitin Sulfates / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000453:epidemiology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism*; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D010044:Outpatient Clinics, Hospital; D050177:Overweight / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012306:Risk; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002809:Chondroitin Sulfates; D006497:Heparan Sulfate
keywords: Endometrium; glycosaminoglycans; heparan sulfate; infertility; polycystic ovary syndrome