title: Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.
abstract: Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.
authors.affiliation: 1] School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, I-00128 Rome, Italy. [2] European Center for Brain Research/Santa Lucia Foundation, Via del Fosso di Fiorano 65, I-00143 Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Maccarrone
authors.affiliation: Department of Biochemistry and Molecular Biology I and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, E-28040 Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Guzmán
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 702 N Walnut Grove Avenue, Bloomington, Indiana 47405-2204, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Mackie
authors.affiliation: Wolfson Centre for Age-Related Diseases, King's College, London SE1 1UL, United Kingdom.
authors.forename: Patrick
authors.initials: P
authors.lastname: Doherty
authors.affiliation: 1] Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden. [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.
authors.forename: Tibor
authors.initials: T
authors.lastname: Harkany
mesh_terms: D000818:Animals; D002188:Cannabis / Q000009:adverse effects*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D063388:Endocannabinoids / Q000378:metabolism*; D005260:Female; D006801:Humans; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D063388:Endocannabinoids