title: Cytokine production associated with smallpox vaccine responses.
abstract: Smallpox was eradicated 34 years ago due to the success of the smallpox vaccine; yet, the vaccine continues to be studied because of its importance in responding to potential biological warfare and the adverse events associated with current smallpox vaccines. Interindividual variations in vaccine response are observed and are, in part, due to genetic variation. In some cases, these varying responses lead to adverse events, which occur at a relatively high rate for the smallpox vaccine compared with other vaccines. Here, we aim to summarize the cytokine responses associated with smallpox vaccine response to date. Along with a description of each of these cytokines, we describe the genetic and adverse event data associated with cytokine responses to smallpox vaccination.
authors.affiliation: Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Simon
authors.forename: Hannah M
authors.initials: HM
authors.lastname: Salk
authors.forename: Inna G
authors.initials: IG
authors.lastname: Ovsyannikova
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kennedy
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
mesh_terms: D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D012900:Smallpox Vaccine / Q000009:adverse effects* / Q000276:immunology*
chemical_list: D016207:Cytokines; D012900:Smallpox Vaccine
keywords: cellular immunity; cytokines; humoral immunity; smallpox vaccine; vaccines; vaccinia virus