title: Synthetic applications of intramolecular thiol-ene "click" reactions.
abstract: The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated "click" process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry.
authors.affiliation: Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. eoin.scanlan@tcd.ie.
authors.forename: Eoin M
authors.initials: EM
authors.lastname: Scanlan
authors.affiliation: Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. vincent.corce@gmail.com.
authors.forename: Vincent
authors.initials: V
authors.lastname: Corcé
authors.affiliation: Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. maloneao@tcd.ie.
authors.forename: Aoife
authors.initials: A
authors.lastname: Malone
mesh_terms: D057930:Click Chemistry / Q000379:methods; D005609:Free Radicals / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D054330:Thiosugars / Q000737:chemistry
chemical_list: D005609:Free Radicals; D010456:Peptides, Cyclic; D013438:Sulfhydryl Compounds; D054330:Thiosugars