title: A pre-structured helix in the intrinsically disordered 4EBP1.
abstract: The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
authors.affiliation: Biomedical Translational Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 305-806, Korea. khhan600@kribb.re.kr.
authors.forename: Do-Hyoung
authors.initials: DH
authors.lastname: Kim
authors.forename: Chewook
authors.initials: C
authors.lastname: Lee
authors.forename: Ye-Jin
authors.initials: YJ
authors.lastname: Cho
authors.forename: Si-Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Cha
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Lim
authors.forename: T Michael
authors.initials: TM
authors.lastname: Sabo
authors.forename: Christian
authors.initials: C
authors.lastname: Griesinger
authors.forename: Donghan
authors.initials: D
authors.lastname: Lee
authors.forename: Kyou-Hoon
authors.initials: KH
authors.lastname: Han
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry*; D018797:Cell Cycle Proteins; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010750:Phosphoproteins / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; D064267:Intrinsically Disordered Proteins; D010750:Phosphoproteins