title: Adjuvant treatment for post-operative head and neck squamous cell carcinoma.
abstract: One of the mainstays of treatment for locally advanced head and neck squamous cell carcinoma is surgery. However, for post-operative patients with high-risk factors for recurrence, surgery alone is insufficient and improving survival requires adjuvant treatment after surgery. Unlike with most other malignancies, the standard adjuvant treatment for post-operative head and neck cancer patients with high-risk factors for recurrence is radiotherapy concurrent with chemotherapy. This review article focuses on the history and future perspectives of adjuvant treatment for post-operative head and neck squamous cell carcinoma.
authors.affiliation: Department of Medical Oncology/Hematology, Kobe University Hospital, Kobe nkiyota@med.kobe-u.ac.jp.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kiyota
authors.affiliation: Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba.
authors.forename: Makoto
authors.initials: M
authors.lastname: Tahara
authors.affiliation: Department of Otolaryngology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D011184:Postoperative Period; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents
keywords: adjuvant treatment; chemoradiotherapy; head and neck cancer; high-risk factors for recurrence