title: Assessment of diffusion-weighted imaging for characterizing focal liver lesions.
abstract: In 150 patients, 153 hepatic lesions (39 metastases, 27 hemangiomas, 26 hepatocellular carcinomas, 25 cysts, 15 adenomas, 8 focal nodular hyperplasias, 5 abscesses, 4 hamartomas, and 4 cholangiocarcinomas) were evaluated during a 24-month period. Apparent diffusion coefficient (ADC) values of benign lesions (1.994×10(-3) mm(2) s(-1)) were significantly higher than ADC values of malignant lesions (1.070×10(-3) mm(2) s(-1)). Mean ADC value for solid benign lesions (1.143×10(-3) mm(2) s(-1)±0.214×10(-3) mm(2) s(-1)) was not significantly different from malignant lesions. ADC values did not allow differentiating malignant from benign solid lesions (area under the curve=0.61). ADC cutoff value threshold of 1.6×10(-3) mm(2) s(-1) yielded higher accuracy for differentiating benign from malignant lesions.
authors.affiliation: Barts Health NHS Trust. Electronic address: armanparsai@hotmail.com.
authors.forename: Arman
authors.initials: A
authors.lastname: Parsai
authors.affiliation: Royal Marsden NHS Trust.
authors.forename: Imene
authors.initials: I
authors.lastname: Zerizer
authors.affiliation: Barts Health NHS Trust.
authors.forename: Oran
authors.initials: O
authors.lastname: Roche
authors.affiliation: Guy's and St Thomas NHS Trust.
authors.forename: Panos
authors.initials: P
authors.lastname: Gkoutzios
authors.affiliation: Barts Health NHS Trust.
authors.forename: Marc E
authors.initials: ME
authors.lastname: Miquel
mesh_terms: D000038:Abscess / Q000175:diagnosis*; D000236:Adenoma / Q000175:diagnosis; D001650:Bile Duct Neoplasms / Q000175:diagnosis; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D018281:Cholangiocarcinoma / Q000175:diagnosis; D003560:Cysts / Q000175:diagnosis*; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis*; D006222:Hamartoma / Q000175:diagnosis*; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis*; D016609:Neoplasms, Second Primary
keywords: Benign; Diffusion-weighted imaging (DWI); Focal liver lesions; MRI; Malignant