title: Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders.
abstract: We aimed to determine whether variability in the melanocortin-4 receptor (MC4R) gene, predisposing to hyperphagia and obesity, may also be present in nonobese patients with binge-eating behavior or be related to anthropometric or psychopathological parameters in these patients. The coding region of the MC4R gene was sequenced in nonobese patients with binge-eating behavior diagnosed with bulimia nervosa or binge-eating disorder (n=77); individuals with severe early-onset obesity (n=170); and lean women with anorexia nervosa (n=20). A psychometric evaluation (Eating Disorders Inventory-2 and Symptom Checklist 90 Revised inventories) was carried out for all the patients with eating disorders. In the obesity group, 10 different variants were identified, whereas in the binge-eating patients, only two individuals with bulimia nervosa were found to carry the I251L polymorphism, which did not correlate with weight, BMI, or psychopathological features. We found no evidence that mutations in the MC4R gene are associated with binge-eating behavior in nonobese eating disorder patients.
authors.affiliation: aDepartment of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura bEating Disorders Unit, Health Service of Extremadura, Badajoz cService of Clinical Analyses, General University Hospital, Valencia, Spain dDepartment of Life Sciences, Research Center for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gamero-Villarroel
authors.forename: Raquel
authors.initials: R
authors.lastname: Rodriguez-Lopez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Jimenez
authors.forename: Juan A
authors.initials: JA
authors.lastname: Carrillo
authors.forename: Angustias
authors.initials: A
authors.lastname: Garcia-Herraiz
authors.forename: David
authors.initials: D
authors.lastname: Albuquerque
authors.forename: Isalud
authors.initials: I
authors.lastname: Flores
authors.forename: Guillermo
authors.initials: G
authors.lastname: Gervasini
mesh_terms: D000293:Adolescent; D056912:Binge-Eating Disorder / Q000235:genetics* / Q000523:psychology; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000523:psychology; D020641:Polymorphism, Single Nucleotide; D011594:Psychometrics; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D055815:Young Adult
chemical_list: C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4