title: The effect of the shape and size of gold seeds irradiated with ultrasound on the bio-heat transfer in tissue.
abstract: The aim of this report is to propose a new methodology to treat prostate cancer with macro-rod-shaped gold seeds irradiated with ultrasound and develop a new computational method for temperature and thermal dose control of hyperthermia therapy induced by the proposed procedure. A computer code representation, based on the bio-heat diffusion equation, was developed to calculate the heat deposition and temperature elevation patterns in a gold rod and in the tissue surrounding it as a result of different therapy durations and ultrasound power simulations. The numerical results computed provide quantitative information on the interaction between high-energy ultrasound, gold seeds and biological tissues and can replicate the pattern observed in experimental studies. The effect of differences in shapes and sizes of gold rod targets irradiated with ultrasound is calculated and the heat enhancement and the bio-heat transfer in tissue are analyzed.
authors.affiliation: Department of Mathematics and Physics, East Carolina University, Greenville, NC, USA, gkigkitzisi@ecu.edu.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Gkigkitzis
authors.forename: Carlos
authors.initials: C
authors.lastname: Austerlitz
authors.forename: Ioannis
authors.initials: I
authors.lastname: Haranas
authors.forename: Diana
authors.initials: D
authors.lastname: Campos
mesh_terms: D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D008962:Models, Theoretical; D011471:Prostatic Neoplasms / Q000628:therapy*; D015203:Reproducibility of Results; D014464:Ultrasonic Therapy / Q000379:methods*