title: Studies of miscibility and specific interactions of antitumor-active anhydride copolymer and poly(ethylene glycol) blends.
abstract: The blending of polymers is of great interest, since the modification gives rise to diverse physical properties with the functionality of a polymer, without synthesis. Water-soluble antitumor-active poly(maleic anhydride-alt-acrylic acid) poly(MA-alt-AA) and poly(ethylene glycol) (PEG) blends were prepared by casting, and compatible properties were investigated by dilute solution viscometry. Viscosity measurements were made on ternary systems of polymer (1)/polymer (2)/solvent (H2O) and p-dioxane, at different concentrations of PEG and poly(MA-alt-AA). The interaction parameters Δβ, μ, Δk, Δb, β and α, which have been proposed, have been obtained using the viscosity data, to probe the miscibility of the polymer blends. The solid blends prepared were characterized with ATR-FTIR, (1)H-NMR, DTA and TGA.
authors.affiliation: a Division of Polymer Chemistry, Department of Chemistry , Faculty of Science, Hacettepe University , Ankara , Turkey.
authors.forename: Hatice Kaplan
authors.initials: HK
authors.lastname: Can
authors.affiliation: a Division of Polymer Chemistry, Department of Chemistry , Faculty of Science, Hacettepe University , Ankara , Turkey.
authors.forename: Shahed
authors.initials: S
authors.lastname: Parvizikhosroshahi
authors.affiliation: a Division of Polymer Chemistry, Department of Chemistry , Faculty of Science, Hacettepe University , Ankara , Turkey.
authors.forename: Erdem C
authors.initials: EC
authors.lastname: Uluışık
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013696:Temperature; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; C000611876:poly(maleic anhydride-alt-acrylic acid); D011092:Polyethylene Glycols
keywords: antitumor-active copolymers; blend; miscibility; poly(MA-alt-AA); viscosity