title: Human chorionic gonadotrophin as an indicator of persistent gestational trophoblastic neoplasia.
abstract: BACKGROUND
  Gestational trophoblastic neoplasia (GTN) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. Many attempts have been made to improve follow-up procedures, but no studies have evaluated Human Chorionic Gonadotrophin (HCG) as a post treatment indicator. Thus we aimed to know β-HCG variability in post treatment pregnancies.
  
  
  METHODS
  40 Molar affected pregnancies were followed post-surgical treatment by serum β-HCG level in a tertiary level hospital. All subjects were treated by evacuation and followed by β-HCG every week for three weeks, then every month for six months.
  
  
  RESULTS
  30 women were normal (group I) and 10 (group II) diagnosed as GTN cases. Serum β-HCG which obtained serially shown significant differences between two groups (p=0.001). The quantity of β-HCG/week had significantly higher level than normal females (p<0.001) CONCLUSION: Our results suggested that β-HCG serum level could be used as a strong indicator for identifying affected patients at early stage.
authors.affiliation: 1. Assistant Professor of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. dr_aminimoghaddam@yahoo.com.
authors.forename: Soheila
authors.initials: S
authors.lastname: Aminimoghaddam
authors.affiliation: 2. Associate Professor of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran. yarandi_f@yahoo.com.
authors.forename: Fariba
authors.initials: F
authors.lastname: Yarandi
authors.affiliation: 3. Resident of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Nejadsalami
authors.affiliation: 4. Assistant Professor of Legal Medicine, Tehran University of Medical Sciences, Tehran, Iran. ftaftachi@yahoo.com.
authors.forename: Farrokh
authors.initials: F
authors.lastname: Taftachi
authors.affiliation: 5. Resident of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Noor Bakhsh
authors.affiliation: 6. Medical student of Mazandaran University of Medical Ssciences, Sari, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mahmoudzadeh
keywords: Chemotherapy; Gestational trophoblastic neoplasia; Molar pregnancy; β-HCG