title: Localized Epidermal Cysts as a Radiation Recall Phenomenon in a Melanoma Patient Treated with Radiotherapy and the BRAF Inhibitor Vemurafenib.
abstract: BRAF inhibitors are broadly used for metastatic melanoma with BRAF mutations. Their use results in various cutaneous side effects, such as the development of keratoacanthomas and squamous cell carcinomas. We report a patient with metastatic melanoma treated with vemurafenib who developed dozens of histologically confirmed epidermal cysts within 2 months after initiation of vemurafenib administration. The cystic lesions were observed only in the localized area where a large exophytic melanoma tumor mass had been previously irradiated. Localized epidermal cysts may constitute an unusual radiation recall reaction in patients treated with BRAF inhibitors.
authors.affiliation: Department of Dermatology, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: Carine
authors.initials: C
authors.lastname: Houriet
authors.affiliation: Department of Radiotherapy, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: Natalie D
authors.initials: ND
authors.lastname: Klass
authors.affiliation: Department of Dermatology, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: Helmut
authors.initials: H
authors.lastname: Beltraminelli
authors.affiliation: Department of Dermatology, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: Luca
authors.initials: L
authors.lastname: Borradori
authors.affiliation: Department of Dermatology, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Oberholzer
keywords: BRAF inhibitor; Epidermal cysts; Melanoma; Radiotherapy; Side effect; Vemurafenib