title: Cutaneous adverse reactions of amiodarone.
abstract: Dermatological complications of amiodarone are commonly encountered problems in therapy. The incidence in the population of patients with prolonged use of amiodarone reaches nearly 75% according to various sources. Nevertheless, they are often misdiagnosed or overlooked. The aim of this review is to present the current state of knowledge about skin changes induced by amiodarone, including phototoxic and photoallergic reactions, as well as hyperpigmentation. In most cases, the adverse effects are reversible and disappear after discontinuation of the drug. Although the dermatological complications usually do not influence the outcome of the therapy and rarely cause discontinuation of treatment, they have a great impact on patient quality of life.
authors.affiliation: Department of Cardiology and Hypertension, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jaworski
authors.affiliation: Department of Dermatology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Walecka
authors.affiliation: Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Rudnicka
authors.affiliation: Department of Traumaorthopedic Surgery, District Hospital, Wołomin, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Gnatowski
authors.affiliation: Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Dariusz A
authors.initials: DA
authors.lastname: Kosior
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D017454:Dermatitis, Photoallergic / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000473:pathology; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced; D012867:Skin / Q000187:drug effects*
chemical_list: D000638:Amiodarone