title: Increased circulating myeloid-derived suppressor cells correlate with cancer stages, interleukin-8 and -6 in prostate cancer.
abstract: OBJECTIVE
  Myeloid-derived suppressor cells (MDSCs) are a population of cells which negatively regulate immune response during tumor progression. In this study, we assessed the accumulation of MDSCs (CD33(+)CD11b(+)HLA-DR(-)CD14(-)) in patients with prostate cancer and its clinical relevance.
  
  
  METHODS
  We tested the frequency of MDSCs in the peripheral blood of patients with prostate cancer or benign prostate hyperplasia and healthy donors. Serumal interleukin-8, -6 and -10 were analyzed. Effects of MDSCs on the T cell response were determined.
  
  
  RESULTS
  MDSCs increased in cancer patients, and there was an association between MDSCs and cancer stages or overall survival. Elevated serumal interleukin-8 and -6 in cancer patients correlated with MDSCs. Moreover, accumulation of MDSCs was associated with defective T cell function.
  
  
  CONCLUSIONS
  Our study showed an increased population of MDSCs in patients with prostate cancer. Interleukin-8 and -6 in serum may play a new important role companied with MDSCs in prostate cancer.
authors.affiliation: Department of Urology, Inner Mongolia People's Hospital Hohhot, Inner Mongolia Autonomous Region, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Chi
authors.affiliation: Department of Urology, Inner Mongolia People's Hospital Hohhot, Inner Mongolia Autonomous Region, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Department of Urology, Inner Mongolia People's Hospital Hohhot, Inner Mongolia Autonomous Region, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Ma
authors.affiliation: Department of Pharmacy, The Affiliated Hospital of Inner Mongolia Medical University Hohhot, Inner Mongolia Autonomous Region, China.
authors.forename: Lidao
authors.initials: L
authors.lastname: Bao
authors.affiliation: Department of Urology, Inner Mongolia People's Hospital Hohhot, Inner Mongolia Autonomous Region, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Yun
keywords: IL-6; IL-8; MDSCs; prostate cancer