title: [Clinical effect of Yisui decoction plus western medicine in treating multiple system atrophy].
abstract: To observe the clinical effect of Yisui decoction plus western medicine in treating multiple system atrophy patients, totally 65 patients from China-Japan Friendship hospital during 2008-2012 with complete clinical data and received consecutive traditional Chinese medicine and western medicine treatment for more than 3 months were observed changes of traditional Chinese medicine symptom score, part 1 of unified multiple system atrophy rating scale, orthostatic hypotension before treatment and after 3 months treatment. After 3 months treatment, total effective rate of traditional Chinese medicine symptom was 70.8%. Compared with before treatment, score of part 1 of unified multiple system atrophy rating scale was obviously reduced after 3 month treatment (P < 0.001). Ex- cept swallow function without significant improvement, the remaining projects of unified multiple system atrophy rating scale were im- proved obviously (P < 0.05), of which the most obvious differences were orthostatic symptoms, falls and intestinal function (P < 0.001). Orthostatic hypotension after 1 month treatment and 3 month treatment was obviously better than before treatment (P < 0.001). There was no significant difference in orthostatic hypotension between 1 month treatment and 3 month treatment. The research results show that Yisui decoction plus western medicine has a certain effect on improving clinical symptoms of multiple system atrophy patients, especially has a significant effect on orthostatic hypotension, and can maintain a stable clinical effect in a certain period of time.
authors.forename: Pei-Ran
authors.initials: PR
authors.lastname: Zhang
authors.forename: Gai-Hui
authors.initials: GH
authors.lastname: Guo
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Gu
authors.forename: Zi-Yi
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Miao
authors.initials: M
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy; D008297:Male; D008516:Medicine, Chinese Traditional / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome