title: Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors.
abstract: OBJECTIVE
  Treatment results evaluation (radical cystectomy and adjuvant chemo/radiotherapy) in patients with urothelial carcinoma, squamous differentiation carcinoma and pure squamous bladder carcinoma.
  
  
  METHODS
  The study included 361 patients with invasive bladder carcinoma treated between 1990-2013. Histology showed 296 cases of urothelial carcinoma (82% - group A), 52 cases of urothelial divergent differentiation (squamous and urothelial carcinoma 14.4% - group B) and 13 cases of squamous cell carcinoma (3.6% - group C). All patients benefited from radical cystectomy. Adjuvant chemotherapy was undergone in 68 patients.
  
  
  RESULTS
  Group A - urothelial carcinoma - had a 44% rate of patients alive with a mean survival period of 73 months. About 56% of the patients died, the mean survival period being 4 years. Group B - urothelial carcinoma with squamous differentiation - had a mean survival period of 36 months (between 1-156 months). 17 patients (33%) are alive at 50 months postoperatively. Group C - squamous carcinoma - had a mean survival period of 9.4 months.
  
  
  CONCLUSIONS
  Locally advanced disease was diagnosed in 50% of the patients in group A, while in group B the rate was 84.6% and 70% in group C, respectively.
  
  
  CONCLUSIONS
  Squamous pattern detected in the histopathological specimen represents a negative prognostic factor. It seems that the squamous component influences the outcome of the disease due to its biological characteristics in the evolution of squamous carcinoma, with advanced local stage disease at diagnosis - late onset of symptoms and lack of response to adjuvant treatment.
authors.affiliation: Department of Surgical Urology, Dialysis and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest.
authors.forename: G
authors.initials: G
authors.lastname: Gluck
authors.affiliation: Department of Pathology, "Fundeni" Clinical Institute, Bucharest.
authors.forename: M
authors.initials: M
authors.lastname: Hortopan
authors.affiliation: Department of Medical Oncology, "Alexandru Trestioreanu" Oncologic Institute, Bucharest.
authors.forename: D
authors.initials: D
authors.lastname: Stănculeanu
authors.affiliation: Department of Surgical Urology, Dialysis and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest.
authors.forename: M
authors.initials: M
authors.lastname: Chiriță
authors.affiliation: Department of Surgical Urology, Dialysis and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest.
authors.forename: R
authors.initials: R
authors.lastname: Stoica
authors.affiliation: Department of Surgical Urology, Dialysis and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest.
authors.forename: I
authors.initials: I
authors.lastname: Sinescu
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*; D014571:Urologic Neoplasms / Q000473:pathology / Q000601:surgery*
keywords: squamous; squamous differentiation; urothelial