title: Therapeutic effects of total alkaloids of Fructus Hordei Germinatus in hyperprolactinemis rats.
abstract: Fructus Hordei Germinatus is widely used in treating hyperprolactinemia as a kind of Chinese traditional herb in China. However, its active composition of curing hyperprolactinemia remains unclear. This study investigates the activity of total alkaloids of F. H. Germinatus (AFH) in hyperprolactinemia rats. High-dose, middle-dose and low-dose AFH were administered into the stomach of hyperprolactinemia rats for 30 days. It revealed that high-dose AFH had obvious curative effect in treating hyperprolactinemia. It could regulate serum E2, P, PRL, FSH, LH levels to normal, decrease the pituitary prolactin positive cell number, mRNA expression level and inhibit the hyperplasia of mammary gland in hyperprolactinemia model rats effectively. The F. H. Germinatus contained total alkaloids 42. 74±0. 08mg hordenine equivalent (HE)/g the sample using acid dye colorimetry method. F. H. Germinatus should be developed as an anti-hyperprolactinemia product deeply.
authors.affiliation: Department of Pharmacy, The Third Hospital of Wuhan, Wuhan, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Xiong
authors.affiliation: Department of Pharmacy, The Third Hospital of Wuhan, Wuhan, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pharmacy, The Third Hospital of Wuhan, Wuhan, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Jin-Hu
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008321:Mammary Glands, Animal / Q000473:pathology; D008516:Medicine, Chinese Traditional; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D005640:Follicle Stimulating Hormone