title: Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer.
abstract: Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. However, the association between genetic variants in HOTAIR and cancer risk has not yet been reported. In the present study, we performed a two-stage case-control study to investigate the association between HOTAIR tagSNPs and the risk of colorectal cancer. We found that individuals with rs7958904 CC genotype had a significantly decreased risk of colorectal cancer in both Stage 1 and 2, compared with those carrying GG genotype [odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.51-0.97 in Stage 1; OR = 0.58, 95% CI = 0.37-0.91 in Stage 2; OR = 0.67, 95% CI = 0.51-0.87 in combined stage]. The subsequently stratified analyses showed that the protective effect of rs7958904 was more pronounced in several subgroups. In summary, our study showed that genetic variants in HOTAIR were associated with risk of colorectal cancer and rs7958904 may act as a potential biomarker for predicting the risk of colorectal cancer.
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health.
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University.
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health.
authors.forename: Gaoxiang
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health.
authors.forename: Qiuhan
authors.initials: Q
authors.lastname: Hua
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center.
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University.
authors.forename: Jinfei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, drzdzhang@gmail.com mwang@njmu.edu.cn.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, drzdzhang@gmail.com mwang@njmu.edu.cn.
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*; D012306:Risk
chemical_list: C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding