title: Polylactide conjugates of camptothecin with different drug release abilities.
abstract: Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems-important delivery systems for anti-cancer agents.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. eoledzka@wp.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Oledzka
authors.affiliation: Centre of New Technologies, University of Warsaw, Banacha 2c, Warsaw 02-097, Poland. phoreglad@uw.edu.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Horeglad
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. zuzannagruszczynska@yahoo.com.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Gruszczyńska
authors.affiliation: Chair of Polymer Chemistry and Technology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland. aplichta@ch.pw.edu.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Plichta
authors.affiliation: Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. gnalecz@wum.edu.pl.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Nałęcz-Jawecki
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. marcin.sobczak@wp.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
mesh_terms: D048908:Aliivibrio fischeri / Q000187:drug effects; D002166:Camptothecin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D066244:Proton Magnetic Resonance Spectroscopy; D018675:Toxicity Tests
chemical_list: D011091:Polyesters; C033616:poly(lactide); D002166:Camptothecin