title: Age-specific changes in left ventricular diastolic function: a velocity-encoded magnetic resonance imaging study.
abstract: OBJECTIVE
  Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations.
  
  
  METHODS
  We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided: 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E') peak velocity.
  
  
  RESULTS
  MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E' (r = -0.63, p < 0.0001) and flow-rate parameters were strongly and independently associated to age (Ef/Af:r = -0.63, DT:r = 0.46, IVRT:r = 0.44, Ef/FV:r = -0.55, Af/FV:r = 0.56, p < 0.0001). Furthermore, LV relaxation parameters (E', DT, IVRT), were independently associated to LV remodelling (LV mass/end-diastolic volume) and myocardial wall thickness (p < 0.01).
  
  
  CONCLUSIONS
  PC-MRI age-related reference ranges of diastolic parameters are provided. Such parameters might be useful for a fast, reproducible and reliable characterization of diastolic function in patients referred for clinical MRI exam
  
  
  CONCLUSIONS
  • MRI age-related reference values of left ventricular diastolic parameters are provided. • MRI diastolic parameters can characterise sub-clinical age-related variations in healthy individuals. • Diastolic function would complement cardiac MRI exam with currently neglected data. • Diastolic function would enhance MRI diagnostic value in cardiomyopathy and heartfailure.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, 75013, Paris, France.
authors.forename: Golmehr
authors.initials: G
authors.lastname: Ashrafpoor
authors.forename: Emilie
authors.initials: E
authors.lastname: Bollache
authors.forename: Alban
authors.initials: A
authors.lastname: Redheuil
authors.forename: Alain
authors.initials: A
authors.lastname: De Cesare
authors.forename: Alain
authors.initials: A
authors.lastname: Giron
authors.forename: Carine
authors.initials: C
authors.lastname: Defrance
authors.forename: Arshid
authors.initials: A
authors.lastname: Azarine
authors.forename: Ludivine
authors.initials: L
authors.lastname: Perdrix
authors.forename: Magalie
authors.initials: M
authors.lastname: Ladouceur
authors.forename: Benoît
authors.initials: B
authors.lastname: Diebold
authors.forename: Elie
authors.initials: E
authors.lastname: Mousseaux
authors.forename: Nadjia
authors.initials: N
authors.lastname: Kachenoura
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D003971:Diastole; D005260:Female; D064368:Healthy Volunteers; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult