title: Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity.
abstract: Treatment of neural cells with calix[n]arenes featuring sulphonate moieties and linked to Ag nanoparticles results in reduced reactive species. For Gram+ bacteria there is an inverse correlation between anti-bacterial activity and ROS reduction whereas for Gram- bacteria only calix[6]arenes bearing O-alkyl sulphonate functions act as ROS inhibitors and anti-bacterial agents.
authors.affiliation: Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Crawley, 6009 WA, Australia. lindy.fitzgerald@uwa.edu.au.
authors.forename: E K
authors.initials: EK
authors.lastname: Stephens
authors.forename: Y
authors.initials: Y
authors.lastname: Tauran
authors.forename: A W
authors.initials: AW
authors.lastname: Coleman
authors.forename: M
authors.initials: M
authors.lastname: Fitzgerald
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D047250:Calixarenes / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D018698:Glutamic Acid / Q000633:toxicity; D006090:Gram-Negative Bacteria / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012834:Silver / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species; D047250:Calixarenes; D018698:Glutamic Acid; D012834:Silver