title: Modified ultrafiltration in adult patients undergoing cardiac surgery.
abstract: A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was the impact of modified ultrafiltration on adult patients undergoing cardiac surgery in terms of inflammatory and metabolic changes, blood loss and early clinical outcomes. A total of 155 papers were identified using the search as described below. Of these, six papers presented the best evidence to answer the clinical question as they reported data to reach conclusions regarding the issues of interest for this review. The author, date and country of publication, patient group, study type and weaknesses and relevant outcomes were tabulated. Modified ultrafiltration in adult patients undergoing cardiac surgery seems to attenuate the levels of inflammatory molecules associated with surgery, reduces blood loss and blood transfusion and improves cardiac output, index and systemic vascular resistance. However, this was not translated in any reduction in length of stay in intensive care unit or hospital. Most studies were single-centre prospective non-blinded trials that included a small cohort of elective coronary artery bypass grafting patients, which makes it underpowered to provide unbiased evidence regarding clinical outcomes. Properly designed and conducted prospective randomized studies are required to answer whether the beneficial effect of modified ultrafiltration on systemic inflammatory molecules associated with surgery can translate with improvement in clinical outcome.
authors.affiliation: Bristol Heart Institute, Bristol, UK mustafazakkar@me.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Zakkar
authors.affiliation: Bristol Heart Institute, Bristol, UK.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Guida
authors.affiliation: Bristol Heart Institute, Bristol, UK.
authors.forename: Gianni D
authors.initials: GD
authors.lastname: Angelini
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures; D017558:Elective Surgical Procedures / Q000379:methods*; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D014462:Ultrafiltration / Q000379:methods
keywords: Blood loss; Cardiac surgery; Early outcomes; Inflammation; Modified ultrafiltration