title: Relationship between high-sensitivity cardiac troponin I and blood pressure among young and healthy adults.
abstract: BACKGROUND
  The aim of this study was to evaluate the relationship of cardiac troponin (cTn) levels with conventional and ambulatory blood pressure (BP) in young and healthy adults.
  
  
  METHODS
  We performed a population based cross-sectional analysis among 2,072 young and healthy adults aged 25-41 years free of cardiovascular disease and diabetes mellitus. cTnI was measured using a highly sensitive (hs) assay. The relationships of high sensitivity cardiac tropononin I (hs-cTnI) with office and 24-hour BP were assessed using multivariable regression analyses.
  
  
  RESULTS
  Median age was 37 years and 975 (47%) participants were male. hs-cTnI levels were detectable in 2,061 (99.5%) individuals. Median (interquartile range) hs-cTnI levels were 0.98 (0.71; 1.64) ng/L among men and 0.48 (0.33; 0.71) ng/L among women. Systolic BP, but not diastolic BP, gradually increased across hs-cTnI quartiles (118, 120, 121, and 122 mm Hg for conventional BP; P = 0.0002; 122, 123, 124, and 124 mm Hg for 24-hour BP, P = 0.0001). In multivariable linear regression analyses, the β estimates for systolic BP per 1-unit increase in log transformed hs-cTnI were 2.52 for conventional BP (P = 0.0001); 2.75 for 24-hour BP (P < 0.0001); 2.71 and 2.41 (P < 0.0001 and P = 0.0002) for day and nighttime BP, respectively. There was a significant relationship between hs-cTnI and the Sokolow-Lyon Index (odds ratio (95% confidence interval): 2.09 (1.37; 3.18), P < 0.001).
  
  
  CONCLUSIONS
  Using a hs assay, hs-cTnI was detectable in virtually all participants of a young and healthy population. hs-cTnI was independently associated with systolic BP and left ventricular hypertrophy.
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland;
authors.forename: Stefanie
authors.initials: S
authors.lastname: Aeschbacher
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland;
authors.forename: Tobias
authors.initials: T
authors.lastname: Schoen
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland;
authors.forename: Matthias
authors.initials: M
authors.lastname: Bossard
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland;
authors.forename: Stephanie
authors.initials: S
authors.lastname: van der Lely
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland;
authors.forename: Kathrin
authors.initials: K
authors.lastname: Glättli
authors.affiliation: Singulex Inc., Clinical Research, Alameda, California;
authors.forename: John
authors.initials: J
authors.lastname: Todd
authors.affiliation: Singulex Inc., Clinical Research, Alameda, California;
authors.forename: Joel
authors.initials: J
authors.lastname: Estis
authors.affiliation: Labormedizinisches Zentrum Dr Risch, Schaan, Principality of Liechtenstein; Division of Laboratory Medicine, Kantonsspital Graubünden, Chur, Switzerland;
authors.forename: Martin
authors.initials: M
authors.lastname: Risch
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland; Cardiology Division, University Hospital Basel, Basel, Switzerland;
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
authors.affiliation: Labormedizinisches Zentrum Dr Risch, Schaan, Principality of Liechtenstein; Division of Clinical Biochemistry, Medical University Innsbruck, Innsbruck, Austria; Private University, Triesen, Florida.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Risch
authors.affiliation: Department of Medicine, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, Basel, Switzerland; david.conen@usb.ch.
authors.forename: David
authors.initials: D
authors.lastname: Conen
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D013223:Statistics as Topic; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I
keywords: ambulatory blood pressure monitoring; blood pressure; cardiac troponins; hypertension; population based.