title: Inhibition of c-Kit by tyrosine kinase inhibitors.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Galanis
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA levisma@jhmi.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: Levis
mesh_terms: D000631:Aminopyridines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D052160:Benzothiazoles / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D000069439:Dasatinib; D015870:Gene Expression; D006197:Hair / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007191:Indazoles; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D009536:Niacinamide / Q000031:analogs & derivatives / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use; D010858:Pigmentation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D011743:Pyrimidines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D000077157:Sorafenib; D013449:Sulfonamides / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D000631:Aminopyridines; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D015415:Biomarkers; D007191:Indazoles; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; D013844:Thiazoles; D009536:Niacinamide; C000600259:pexidartinib; C544967:quizartinib; C516667:pazopanib; D000077157:Sorafenib; C497970:FLT3 protein, human; D019009:Proto-Oncogene Proteins c-kit; D051941:fms-Like Tyrosine Kinase 3; D000069439:Dasatinib
keywords: c-Kit inhibition; hair depigmentation; myelosuppression; tyrosine kinase inhibitors