title: New reference data on bone mineral density and the prevalence of osteoporosis in Korean adults aged 50 years or older: the Korea National Health and Nutrition Examination Survey 2008-2010.
abstract: This cross-sectional study was performed to investigate the reference values for bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) and the prevalence of osteoporosis in the Korean population by applying domestic reference data. In total, 25,043 Korean adults ≥20 yr of age (11,792 men and 13,251 women) participated in the study. The BMDs of the total hip, femoral neck, and lumbar spine were measured by DXA (Discovery-W, Hologic Inc.), and subjects with a BMD - 2.5 standard deviations or lower than the mean BMD for young adults (20-29 yr old) were considered to have osteoporosis. When applying the new reference values determined in this study from Korean subjects, the overall prevalence of osteoporosis increased in men aged ≥50 yr compared with that provided by the DXA manufacturer from Japanese subjects (12.2% vs. 7.8%, P<0.001) and decreased in postmenopausal women aged ≥50 yr (32.9% vs. 38.7%, P<0.001). According to the findings of this study, use of the reference values provided by the DXA manufacturer has resulted in the underdiagnosis of osteoporosis in Korean men and the overdiagnosis of osteoporosis in Korean women. Our data will serve as valuable reference standards for the diagnosis and management for osteoporosis in the Korean population.
authors.affiliation: Department of Family Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Kyung-Shik
authors.identifier: 0000-0002-5107-9025
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Ajou University Hospital, Suwon, Korea.
authors.forename: Su-Hyun
authors.identifier: 0000-0003-3289-6596
authors.initials: SH
authors.lastname: Bae
authors.affiliation: Department of Family Medicine, Ajou University Hospital, Suwon, Korea.
authors.forename: Seung Hwa
authors.identifier: 0000-0002-1250-8069
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
authors.forename: Jungun
authors.identifier: 0000-0001-8580-1445
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
authors.forename: Dong Ryul
authors.identifier: 0000-0001-7255-4561
authors.initials: DR
authors.lastname: Lee
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D044466:Asian People; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D010024:Osteoporosis / Q000175:diagnosis* / Q000453:epidemiology; D015995:Prevalence; D012016:Reference Values; D056910:Republic of Korea
keywords: Absorptiometry, Photon; Bone Density; Korean; Osteoporosis; Reference Values