title: Caffeic acid loading wound dressing: physicochemical and biological characterization.
abstract: OBJECTIVE
  Caffeic acid has been described as active against bacteria commonly isolated from wound infections. However, its low stability and poor solubility reduce caffeic acid applicability as a pharmaceutical product. These parameters can be enhanced by complexation with cyclodextrin. The main goal of the present work was to incorporate caffeic acid on cyclodextrin-based hydrogels capable of controlled delivery, in order to be used as antibacterial wound dressing.
  
  
  METHODS
  Cyclodextrin-based hydrogels were prepared by direct crosslinking of β-cyclodextrin or hydroxypropyl-β-cyclodextrin with 1,4-butanediol diglycidyl ether in the presence of hydroxypropyl methylcellulose.
  
  
  RESULTS
  The hydrogels obtained combine good physicochemical properties (viscoelasticity, superabsorbency and high ability to retain and deliver caffeic acid) with the preservation of caffeic acid' antibacterial activity and effect on fibroblasts, with gel-β-cyclodextrin the most suited.
  
  
  CONCLUSIONS
  The hydrogels obtained could be useful as caffeic acid delivery-system devices for the treatment of wound infections.
authors.affiliation: CEB, Centre for Biological Engineering, LIBRO -Laboratório de Investigação em Biofilmes RosárioOliveira, University of Minho, Campus Gualtar,4710-057 Braga, Portugal.
authors.forename: Eva
authors.initials: E
authors.lastname: Pinho
authors.forename: Mariana
authors.initials: M
authors.lastname: Henriques
authors.forename: Graça
authors.initials: G
authors.lastname: Soares
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001458:Bandages; D002072:Butylene Glycols / Q000737:chemistry; D002109:Caffeic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004355:Drug Stability; D004548:Elasticity; D005347:Fibroblasts / Q000187:drug effects; D020100:Hydrogels; D065347:Hypromellose Derivatives / Q000737:chemistry* / Q000633:toxicity; D007700:Kinetics; D051379:Mice; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014783:Viscosity; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D002072:Butylene Glycols; D002109:Caffeic Acids; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D065347:Hypromellose Derivatives; C014376:1,4-bis(2,3-epoxypropoxy)butane; C040048:caffeic acid