title: Management of liver transplantation waiting list for decompensated cirrhosis in a Spanish tertiary hospital: differences between hepatitis C virus recipients and other etiologies.
abstract: BACKGROUND
  Decompensated cirrhosis due to hepatitis C virus (HCV) is one of the main indications for liver transplantation (LT) in Spain. Recurrence of HCV after LT is the main cause of graft loss and death in HCV-positive recipients. Advanced donor age determines a more aggressive recurrence of HCV and a shorter survival. In this setting, in our liver unit, grafts from younger donors are allocated to HCV-positive recipients. The aim of this study was a comparative analysis of allocation of grafts in HCV-positive recipients versus other etiologies and the impact on waiting list time, Model for End-Stage Liver Disease (MELD) score progression until LT, need of admission in a hospital, survival until LT.
  
  
  METHODS
  This was a retrospective study from the cohort of patients included in the waiting list for LT owing to decompensated cirrhosis in the Hospital Gregorio Marañón from January 2008 to June 2013.
  
  
  RESULTS
  A total of 91 patients were included; 63 patients (69.23%) received LT; 19 (20.88%) retired from the waiting list: 6 because of improvement, 11 (12.08%) because of death. In both groups, the age of recipients was similar (HCV 52 y vs other 53 y; P = .549). HCV patients were included in the waiting list with lower MELD score than other etiologies (HCV 16.1 vs other 19.4; P = .010); nevertheless, MELD score was similar at the time of LT in both groups (HCV 18.9 vs other 19.4; P = .675). Time on waiting list was significantly longer in HCV patients (198 d vs 86 d; P = .002) and they were admitted in hospital more days (30 d vs 12 d; P = .03). Donor age in the HCV group was significantly lower (64.3 y vs 54.7 y; P = .006). The intention-to-treat survival analysis did not show differences between the groups (log rank = 0.504).
  
  
  CONCLUSIONS
  HCV patients with decompensated cirrhosis receive grafts from younger donors. HCV patients remain waiting longer for an optimal organ and suffer MELD deterioration and more days admitted in hospital. These differences in allocation of grafts did not affect final survival. In our experience, designating younger organs to HCV-positive patients does not penalize neither HCV recipients nor recipients with other etiologies.
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ibáñez Samaniego
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez Valderas
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernández Yunquera
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Rincón Rodríguez
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: López Baena
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Matilla Peña
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: M V
authors.initials: MV
authors.lastname: Catalina Rodríguez
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Clemente Ricote
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Bañares Cañizares
authors.affiliation: Liver Unit, Gregorio Marañón University Hospital, Madrid, Spain. Electronic address: coordinacionth.hgugm@salud.madrid.org.
authors.forename: M
authors.initials: M
authors.lastname: Salcedo Plaza
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000821:virology; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D062606:Tertiary Care Centers; D066027:Transplant Recipients; D014850:Waiting Lists