title: A new ester coumarin from Ferula Persica wild, indigenous to Iran.
abstract: Ferula persica wild (Apiaceae) is a perennial herb indigenous to Iran. It has been used in folk medicine for treatment of diabetes, lowering of blood pressure and for antispasmodic, carminative, laxative and expectorant effects in central Iran. Dried ground roots of F. persica (150 g) were extracted sequentially with n-hexane, dichloromethane and methanol (MeOH), 500 ml each, using a Soxhlet apparatus. The n-hexane extract of the roots (3 g) was subjected to vacuum liquid chromatography on silica gel, eluting with solvent mixtures of increasing polarity: 100% n-hexane-ethyl acetate (EtOAc), to yield a number of fractions, Fraction 4 (80% EtOAc in n-hexane) was further analysed by preparative TLC (mobile phase was 12% acetone in chloroform) to yield a coumarin ester (10.1 mg, Rf = 0.31, blue florescent). The structure of the isolated compound was elucidated by spectroscopic means. The compound is 7-O-(4,8,12 -trihydroxy-4,8,12-trimethyl-tridecanoyl)-coumarin, named, ferulone C as a new natural product.
authors.affiliation: a Department of Biology , Faculty of Sciences, University of Mohaghegh Ardabili , Ardabil , Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Razavi
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Janani
mesh_terms: D005591:Chemical Fractionation; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D005309:Ferula / Q000737:chemistry*; D007492:Iran; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D003374:Coumarins; D010936:Plant Extracts; C000598302:ferulone C; C030123:coumarin
keywords: Ferula persica; coumarin ester; ferulone C