title: [HIV-related malignancies: state of art].
abstract: HIV infection is related to an increased risk of cancer compared with general population, both AIDS-defining cancers (Kaposi's sarcoma, non Hodgkin's lymphoma, invasive cervical cancer) and non-AIDS-defining cancers. Although the advent of the highly active antiretroviral therapy era has decreased the Kaposi's sarcoma and non-Hodgkin's lymphoma incidences, non-AIDS-defining malignancies, such as lung cancer, hepatocarcinoma, anal cancer and skin cancers, remain a major cause of morbidity and death in the HIV-infected population. The clinical presentation is often different between the infected and non-infected populations, often with a more advanced stage at diagnosis, a more aggressive pathology, and associated morbidities like immunosuppression, leading to poorer outcomes. Numerous studies have focused on HIV-related malignancies' treatment, however specific guidelines are still missing. Practitioners have to be careful with interactions between antiretroviral and antineoplastic drugs, particularly through the cytochrome P 450. Because of this, a national multidisciplinary approach, "Cancer and HIV, " was started in 2013 thanks to the National Institute of Cancer (INCa). The aim of this review is to present a scientific update about AIDS-and non-AIDS-defining malignancies, both in their clinical aspects and regarding their specific therapeutic management.
authors.affiliation: Centre René Huguenin, Service radiothérapie, 35, rue Dailly, 92210 Saint-Cloud, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Gobert
authors.affiliation: Centre hospitalo-universitaire l'Archet, Service hématologie, 151, rue St-Antoine-de-Ginestière, 06200 Nice, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mounier
authors.affiliation: Centre hospitalo-universitaire Tenon, APHP, Université Paris-VI, Service de pneumologie, 4, rue de la Chine, 75970 Paris cedex, France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Lavole
authors.affiliation: Université Aix-Marseille, APHM Hôpital Sainte-Marguerite, Service d'immuno-hématologie clinique, Inserm U912 (SESSTIM), 270, boulevard Sainte-Marguerite, 13274 Marseille cedex 9, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Poizot-Martin
authors.affiliation: Groupe hospitalier Pitié-Salpêtrière, AP-HP, Université Paris-VI, Service d'oncologie médicale, 47-83, boulevard de l'Hôpital, 75651 Paris cedex, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Spano
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents
keywords: HIV infection; Kaposi's sarcoma; cutaneous malignancies; hepatocarcinoma; lymphomas; neoplasms