title: Duodenal perforation: an unusual complication of sickle cell anemia.
abstract: Duodenal perforation in childhood is a rare condition with a high mortality rate if not treated surgically. Primary gastroduodenal perforation is frequently associated with peptic ulcer and exhibits a positive family history. Helicobacter pylorus is the most significant agent. Secondary gastroduodenal perforation may be a finding of specific diseases, such as Crohn disease, or more rarely may be associated with diseases such as cystic fibrosis or sickle cell anemia. A 14-year-old boy presented with abdominal and back pain. The patient was operated on for acute abdomen and diagnosed with duodenal perforation. Helicobacter pylorus was negative. There was no risk factor to account for duodenal perforation other than sickle cell anemia. Surgical intervention was successful and without significant sequelae. Duodenal perforation is a rare entity described in patients with sickle cell anemia. To our knowledge, this is the first report of duodenal perforation in a patient sickle cell anemia.
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatric Hematology and Oncology, Hatay, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Acıpayam
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatrics, Hatay, Turkey.
authors.forename: Güliz
authors.initials: G
authors.lastname: Aldıç
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatric Surgery, Hatay, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Akçora
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatric Surgery, Hatay, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Çelikkaya
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatrics, Hatay, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Aşkar
authors.affiliation: Mustafa Kemal University, School of Medicine, Department of Pediatrics, Hatay, Turkey.
authors.forename: Bayram Ali
authors.initials: BA
authors.lastname: Dorum
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D004378:Duodenal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male
keywords: Sickle cell anemia; abdominal pain; duodenal perforation