title: The modified Glasgow prognostic score for early mortality in patients with synchronous peritoneal carcinomatosis from colorectal cancer.
abstract: OBJECTIVE
  Few studies have investigated the risk factors in patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) who die within 3 months of undergoing surgical intervention and systemic chemotherapy. This study aimed to identify the risk factors associated with the post-treatment 3-month mortality rate.
  
  
  METHODS
  Retrospectively collected data from Hiroshima University were analyzed for patients presenting with synchronous PC from CRC between 1992 and 2012. The clinical, histological and survival data were evaluated and correlated with the overall survival rate at 3 months after surgical intervention.
  
  
  RESULTS
  In patients who underwent surgical intervention with systemic chemotherapy for synchronous PC from CRC (N = 65), a Kaplan-Meier analysis and the log-rank test revealed that systemic chemotherapy (P = 0.023) and the modified Glasgow Prognostic Score (mGPS) (P = 0.00001) were associated with the 3-month mortality rate. Multivariate analyses using these two factors revealed that the mGPS (0/1, 2) (odds ratio 8.087; 95 % CI 1.512-43.25; P = 0.015) was an independent risk factor for the 3-month mortality rate.
  
  
  CONCLUSIONS
  The mGPS is an important independent predictor of the 3-month mortality rate in patients who undergo surgical intervention with systemic chemotherapy for synchronous PC from CRC. The mGPS could aid surgeons in choosing the appropriate treatment strategy and best care for patients.
authors.affiliation: Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan. adachitomohiro@hotmail.com.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Adachi
authors.affiliation: Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan. thinoi@hiroshima-u.ac.jp.
authors.forename: Takao
authors.initials: T
authors.lastname: Hinoi
authors.affiliation: Department of Surgery, Division of Frontier Medical Sciences, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. m-hattori@hiroshima-u.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Hattori
authors.affiliation: Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan. hiroegi@yahoo.co.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Egi
authors.affiliation: Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan. manabus761215@gmail.com.
authors.forename: Manabu
authors.initials: M
authors.lastname: Shimomura
authors.affiliation: Department of Surgery, Division of Frontier Medical Sciences, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. ngywc515@ybb.ne.jp.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Department of Surgery, Division of Frontier Medical Sciences, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. dannte5426@yahoo.co.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sawada
authors.affiliation: Department of Surgery, Division of Frontier Medical Sciences, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. edajimaheihachi_1@yahoo.co.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Miguchi
authors.affiliation: Department of Gastroenterological and Transplant Surgery Division of Medicine, Program of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. hiroaki_niitsu@yahoo.co.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Niitsu
authors.affiliation: Department of Gastroenterological and Transplant Surgery Division of Medicine, Program of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. silentman1087@yahoo.co.jp.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Mukai
authors.affiliation: Department of Gastroenterological and Transplant Surgery Division of Medicine, Program of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan. yano-tuk@umin.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yano
authors.affiliation: Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan. hohdan@hiroshima-u.ac.jp.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohdan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
keywords: Colorectal cancer; Early mortality; Peritoneal carcinomatosis; Synchronous; The modified glasgow prognostic score (mGPS)