title: Myeloid-derived suppressor cells: their role in the pathophysiology of hematologic malignancies and potential as therapeutic targets.
abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at various stages of differentiation/maturation that have a role in cancer induction and progression. They function as vasculogenic and immunosuppressive cells, utilizing multiple mechanisms to block both innate and adaptive anti-tumor immunity. Recently, their mechanism of action and clinical importance have been defined, and the cross-talk between myeloid cells and cancer cells has been shown to contribute to tumor induction, progression, metastasis and tolerance. In this review, we focus on the role of MDSCs in hematologic malignancies and the therapeutic approaches targeting MDSCs that are currently in clinical studies.
authors.affiliation: a Department of Clinical Pharmacology , Menoufia University , Al-Minufya , Egypt.|b Department of Pharmacology and Clinical Pharmacy , College of Medicine and Health Sciences, Sultan Qaboos University , Muscat , Oman.
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Younos
authors.affiliation: c SBI Pharmaceuticals Co., Ltd. , Tokyo 106-6020 , Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Abe
authors.affiliation: d Department of Pathology and Microbiology , Nebraska Medical Center , Omaha , NE , USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Talmadge
mesh_terms: D000818:Animals; D018450:Disease Progression; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism; D011379:Prognosis
keywords: Myeloid-derived suppressor cells; hematologic malignancies; leukemia; lymphoma; multiple myeloma