title: Ligand exchange based paraoxon imprınted QCM sensor.
abstract: In the present work, a paraoxon imprinted QCM sensor has been developed for the determination of paraoxon based on the modification of paraoxon imprinted film onto a quartz crystal combining the advantages of high selectivity of the piezoelectric microgravimetry using MIP film technique and high sensitivity of QCM detection. The paraoxon selective memories have formed on QCM electrode surface by using a new metal-chelate interaction based on pre-organized monomer and the paraoxon recognition activity of these molecular memories was investigated. Molecular imprinted polymer (MIP) film for the detection of paraoxon was developed and the analytical performance of paraoxon imprinted sensor was studied. The molecular imprinted polymer were characterized by FTIR measurements. Paraoxon imprinted sensor was characterized with AFM and ellipsometer. The study also includes the measurement of binding interaction of paraoxon imprinted quartz crystal microbalance (QCM) sensor, selectivity experiments and analytical performance of QCM electrode. The detection limit and the affinity constant (K(affinity)) were found to be 0.06 μM and 2.25 × 10(4) M(-1) for paraoxon [MAAP-Cu(II)-paraoxon] based thin film, respectively. Also, it has been observed that the selectivity of the prepared paraoxon imprinted sensor is high compared to a similar chemical structure which is parathion.
authors.affiliation: Department of Chemistry, Eskişehir Osmangazi University, Eskişehir, Turkey. Electronic address: ebirlik@ogu.edu.tr.
authors.forename: Ebru Birlik
authors.initials: EB
authors.lastname: Özkütük
authors.affiliation: Department of Chemistry Anadolu University, Eskişehir, Turkey.
authors.forename: Sibel Emir
authors.initials: SE
authors.lastname: Diltemiz
authors.affiliation: Department of Chemistry, Eskişehir Osmangazi University, Eskişehir, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Özalp
authors.affiliation: Department of Chemistry Anadolu University, Eskişehir, Turkey.
authors.forename: Rıdvan
authors.initials: R
authors.lastname: Say
authors.affiliation: Department of Chemistry Anadolu University, Eskişehir, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Ersöz
mesh_terms: D006863:Hydrogen-Ion Concentration; D007306:Insecticides / Q000737:chemistry; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods*; D010261:Paraoxon / Q000737:chemistry*; D058525:Quartz Crystal Microbalance Techniques / Q000295:instrumentation*; D015203:Reproducibility of Results; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D007306:Insecticides; D010261:Paraoxon