title: Spontaneous coronary artery dissection: revascularization versus conservative therapy.
abstract: BACKGROUND
  Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic acute coronary syndrome for which optimal management remains undefined.
  
  
  RESULTS
  We performed a retrospective study of 189 patients presenting with a first SCAD episode. We evaluated outcomes according to initial management: (1) revascularization versus conservative therapy and (2) percutaneous coronary intervention (PCI) versus conservative therapy stratified by vessel flow at presentation. Demographics were similar in revascularization versus conservative (mean age, 44±9 years; women 92% both groups), but vessel occlusion was more frequent in revascularization (44/95 versus 18/94). There was 1 in-hospital death (revascularization) and 1 late death (conservative). Procedural failure rate was 53% in those managed with PCI. In the subgroup of patients presenting with preserved vessel flow, rates of PCI failure were similarly high (50%), and 6 (13%) required emergency coronary artery bypass grafting. In the conservative group, 85 of 94 (90%) had an uneventful in-hospital course, but 9 (10%) experienced early SCAD progression requiring revascularization. Kaplan-Meier estimated 5-year rates of target vessel revascularization and recurrent SCAD were no different in revascularization versus conservative therapy (30% versus 19%; P=0.06 and 23% versus 31%; P=0.7).
  
  
  CONCLUSIONS
  PCI for SCAD is associated with high rates of technical failure even in those presenting with preserved vessel flow and does not protect against target vessel revascularization or recurrent SCAD. A strategy of conservative management with prolonged observation may be preferable.
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Marysia S
authors.initials: MS
authors.lastname: Tweet
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Mackram F
authors.initials: MF
authors.lastname: Eleid
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Patricia J M
authors.initials: PJ
authors.lastname: Best
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Lennon
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Charanjit S
authors.initials: CS
authors.lastname: Rihal
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: David R
authors.initials: DR
authors.lastname: Holmes
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN.
authors.forename: Sharonne N
authors.initials: SN
authors.lastname: Hayes
authors.affiliation: From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, MN. gulati.rajiv@mayo.edu.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Gulati
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D003323:Coronary Aneurysm / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality; D003326:Coronary Circulation; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality; D011237:Predictive Value of Tests; D057216:Propensity Score; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: acute coronary syndrome; coronary artery dissection, spontaneous; percutaneous coronary interventions