title: Capsinoids suppress fat accumulation via lipid metabolism.
abstract: Capsaicin, found in red peppers, has been reported to have anti‑obesity, anti‑hypertension, anti‑diabetes and anti‑inflammatory functions. In the present study, we determined the effect of non‑pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice. Liver, the main tissue of lipid metabolism, was treated by capsinoids, and HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4 were found to be increased significantly, which demonstrated promotion of the lipid metabolism in liver and adipose tissues. In addition, by adding capsinoids, the induced adipocytes also demonstrated significantly increased levels of HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4. Oil red O staining also demonstrated that capsinoids decreased fat accumulation in the adipocytes. In conclusion, these results indicate that capsinoids may be worth investigating as a potential cure for obesity.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hong
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xia
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Hu
authors.initials: H
authors.lastname: Xiangying
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Quan
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice
chemical_list: D002211:Capsaicin