title: Epstein-Barr virus and the origin of Hodgkin lymphoma.
abstract: Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
authors.affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, B15 2TT, the United Kingdom. p.g.murray@bham.ac.uk.
authors.forename: Martina
authors.initials: M
authors.lastname: Vockerodt
authors.forename: Fathima Zumla
authors.initials: FZ
authors.lastname: Cader
authors.forename: Claire
authors.initials: C
authors.lastname: Shannon-Lowe
authors.forename: Paul
authors.initials: P
authors.lastname: Murray
mesh_terms: D020031:Epstein-Barr Virus Infections; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D016539:Reed-Sternberg Cells