title: In the beginning: a personal reminiscence on the origin and legacy of ClC-0, the 'Torpedo Cl(-) channel'.
abstract: This unapologetically subjective essay recalls the Torpedo Cl(-) channel in the years when it had neither a molecular identity nor proper name (ClC-0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.
authors.affiliation: Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Miller
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D014101:Torpedo / Q000378:metabolism*
chemical_list: C086321:CLC-1 channel; D018118:Chloride Channels; D002712:Chlorides