title: SnapShot: Mammalian Sirtuins.
abstract: The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.
authors.affiliation: Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Anderson
authors.affiliation: Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Green
authors.affiliation: Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Frank K
authors.initials: FK
authors.lastname: Huynh
authors.affiliation: Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Wagner
authors.affiliation: Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hirschey
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D037761:Sirtuins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037761:Sirtuins