title: Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment.
abstract: The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippo-campus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.
authors.affiliation: Department of Pathology, College of Oriental Medicine, Daegu Haany University, Daegu 706-828.
authors.forename: Chang-Yul
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Pathology, College of Oriental Medicine, Daegu Haany University, Daegu 706-828.
authors.forename: Gil-Yong
authors.initials: GY
authors.lastname: Lee
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 702-701.
authors.forename: Gyu Hwan
authors.initials: GH
authors.lastname: Park
authors.affiliation: Deparment of Biochemistry, School of Medicine, Catholic University of Daegu, Daegu 705-718.
authors.forename: Jongwon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Pharmacology, School of Medicine, Keimyung University, Daegu 704-701, Republic of Korea.
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Jang
keywords: Arabinoxylan; Brain-derived neurotrophic factor; Learning and memory; Scopolamine; cAMP response element binding protein