title: Evaluation of hyperthermia of magnetic nanoparticles by dehydrating DNA.
abstract: A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen, and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs, and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient.
authors.affiliation: 1] State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China [2] Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN. 55455, USA.
authors.forename: Lina
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN. 55455, USA.
authors.forename: Jinming
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN. 55455, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN. 55455, USA.
authors.forename: Todd
authors.initials: T
authors.lastname: Klein
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN. 55455, USA.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Wang
mesh_terms: D004247:DNA / Q000737:chemistry*; D003681:Dehydration / Q000139:chemically induced*; D005334:Fever / Q000139:chemically induced*; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D008280:Magnetics / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D058185:Magnetite Nanoparticles; D004247:DNA