title: Inhibitors of c-Jun N-terminal kinases: an update.
abstract: The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
authors.forename: Pierre
authors.initials: P
authors.lastname: Koch
authors.forename: Matthias
authors.initials: M
authors.lastname: Gehringer
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Laufer
mesh_terms: D002493:Central Nervous System Diseases / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D007527:Isoenzymes; D047428:Protein Kinase Inhibitors; D048031:JNK Mitogen-Activated Protein Kinases