title: Impact of human leukocyte antigen molecules E, F, and G on the outcome of transplantation.
abstract: BACKGROUND
  HLA class I molecules are divided into classic (Ia) and nonclassic (Ib). Nonclassic HLA molecules (E, F, and G) have acquired relevance owing to their immunomodulatory properties and possible repercussions for induction of tolerance in organ transplantation. The objective of this study was to identify the impact of these molecules on transplant success or failure.
  
  
  METHODS
  A systematic review of literature was performed with the use of MeSH terms in Pubmed. Clinical trials, randomized clinical trials, case-control studies, and reviews from the past 15 years were included.
  
  
  RESULTS
  HLA-E*0103/E*0103 genotype is associated with lower risk of graft-versus-host disease, decreased mortality, and greater disease-free survival after bone marrow transplantation. There were no significant associations between HLA-F and clinical outcomes in any of the studies. Elevated serum levels of HLA-G were associated with a lower incidence of rejection in hepatic and renal transplantation during the 1st year and lower T-cell response after bone marrow, liver, and kidney transplantation. Detection of mRNA of HLA-G1 was also associated with less graft rejection.
  
  
  CONCLUSIONS
  Current literature suggests that nonclassic HLA Ib molecules play an important role in immunotolerance in organ transplantation; however, more studies are required to predict outcomes related to specific genotypes.
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia. Electronic address: mpabonporras@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Pabón
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia.
authors.forename: C E
authors.initials: CE
authors.lastname: Navarro
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: J C
authors.initials: JC
authors.lastname: Osorio
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia.
authors.forename: N
authors.initials: N
authors.lastname: Gómez
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia.
authors.forename: J P
authors.initials: JP
authors.lastname: Moreno
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia.
authors.forename: A F
authors.initials: AF
authors.lastname: Donado
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia.
authors.forename: H C
authors.initials: HC
authors.lastname: Pérez
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia.
authors.forename: E
authors.initials: E
authors.lastname: Lozano
mesh_terms: D016026:Bone Marrow Transplantation / Q000401:mortality*; D018572:Disease-Free Survival; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology*; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology*; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation / Q000401:mortality; D016031:Liver Transplantation / Q000401:mortality; D016377:Organ Transplantation / Q000401:mortality*; D017063:Outcome Assessment, Health Care; D000097625:HLA-E Antigens
chemical_list: D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C062341:HLA-F antigens