title: Combined therapeutic effects of low power laser (980nm) and CoQ10 on Neuropathic Pain in adult male rat.
abstract: BACKGROUND
  Neuropathic pain (NP) is one of the most suffering medical conditions that often fail to respond to certain pain therapy. Although its exact etiology is still unknown the role of reactive oxygen species (ROS) and oxidative stress were explored by many researchers. Neuropathies either central or peripheral lead to painful condition as well as social and economic isolation, thus various therapies were used to treat or reduce the pain. Laser therapy and antioxidant drugs have separately considered as treatment for NP, but the combination of them have not been used yet. In order to study the combination effects of Low Level Laser Therapy (LLLT) and Coenzyme Q10 (CoQ10) the present study was designed.
  
  
  METHODS
  Sixty adult male rats (230-320g) were used in this experimental study that divided into six groups (n=10). Chronic constriction injury (CCI) was used to induce neuropathic pain. The CoQ10 or vehicle, a low level laser of 980nm was used for two consecutive weeks. Thermal and mechanical paw withdrawal thresholds were assessed before and after surgery on 7(th) and 14(th) days.
  
  
  RESULTS
  As we expected CCI decreased the pain threshold, whereas CoQ10 administration for two weeks increased mechanical and thermal threshold. The same results obtained for laser therapy using the CCI animals. Combination of laser 980nm with CoQ10 also showed significant differences in CCI animals.
  
  
  CONCLUSIONS
  Based on our findings the combination of CoQ10 with LLLT showed better effects than each one alone. In this regard we believe that there might be cellular and molecular synergism in simultaneous use of CoQ10 and LLLT on pain relief.
authors.affiliation: 1. Associate Professor of Anatomy and Neuroscience, Department of Medical Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. jameie.sb@iums.ac.ir & behjame@gmail.com.
authors.forename: Seyed Behnamedin
authors.initials: SB
authors.lastname: Jameie
authors.affiliation: 2. MSc, Department of Nuclear Engineering, Sciences and Researches branch, Islamic Azad University, Tehran, Iran. masoumipoor@gmail.com.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Masoumipoor
authors.affiliation: 3. PhD Student of Physiology, Department of Medical Basic Sciences, Faculty of Allied Medicine, Research Center of Physiology & Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Atusa_j@yahoo.com.
authors.forename: Atousa
authors.initials: A
authors.lastname: Janzadeh
authors.affiliation: 4. Associated professor of Physiology, Research Center of Physiology & Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. f-nasiri@tums.ac.ir.
authors.forename: Farinaz
authors.initials: F
authors.lastname: Nasirinezhad
authors.affiliation: 5. MD, Department of Medical Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. mhd136355@gmail.com .
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Kerdari
authors.affiliation: 6. Assistant Professor of Anatomy, Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. soleimanimaryam89@gmail.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Soleimani
keywords: Chronic Constriction Injury; Coenzyme Q10; Low Level Laser Therapy; Neuropathic pain