title: Comparison of the migration behavior of nanoparticles based on polyethylene glycol and silica using micellar electrokinetic chromatography.
abstract: Nanoparticles, spherical particles with diameters less than 100 nm, are promising theranostic devices for noninvasive diagnosis and therapy. In this study, nanoparticles composed of polyethylene glycol and silica were prepared, and their migration behavior was examined using capillary electrophoresis. The effects of the sodium dodecyl sulfate concentration in the electrolyte, the nanoparticle size, and the encapsulated molecule on the migration were examined. The addition of sodium dodecyl sulfate into the electrolyte had a significant effect on the electrophoretic mobility of polyethylene glycol nanoparticles, but a small effect on that of silica nanoparticles. As for the size effect, the mobility became a little faster for smaller nanoparticle sizes for both polyethylene glycol and silica nanoparticles. The encapsulated molecule affected the mobility of the nanoparticles through interactions between the encapsulated molecules and sodium dodecyl sulfate. We propose that the large effect of sodium dodecyl sulfate on the migration of the polyethylene glycol nanoparticles was due to the large spaces within the nanoparticles. These results indicate that nanoparticle migration is mainly determined by the nanoparticle components.
authors.affiliation: Graduate School of Pharmaceutical Sciences and GPLLI Program, The University of Tokyo, Tokyo, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kato
authors.forename: Minoru
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ueyama
authors.forename: Ayaka
authors.initials: A
authors.lastname: Koga
authors.forename: Akira
authors.initials: A
authors.lastname: Sano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Higashi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Santa
mesh_terms: D020374:Chromatography, Micellar Electrokinetic Capillary; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry
chemical_list: D012967:Sodium Dodecyl Sulfate; D011092:Polyethylene Glycols; D012822:Silicon Dioxide
keywords: Micellar electrokinetic chromatography; Nanoparticles; Polyethylene glycol; Silica