title: Camel thorn extract reduces activity of angiotensin-converting enzyme in rat aorta increased during aging and treatment with NO-synthase inhibitor.
abstract: We studied the effect of camel thorn extract on activity of angiotensin-converting enzyme in rat aorta increased in animals during aging or treatment with NO-synthase inhibitor. Intake of camel thorn extract with drinking water reduced activity of angiotensin-converting enzyme; the effect increased with increasing the dose of the extract. Angiotensin-converting enzyme activity in older rats and animals treated with NO-synthase inhibitor decreased to the values observed in young control rats at extract concentration of 0.2%. Comparison of the effects of camel thorn extract with those of flavonoid taxifolin showed that the extract was not inferior to taxifolin in preventing the early stages of aortic atherosclerosis caused by increased activity of angiotensin-converting enzyme.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Arutyunyan
authors.forename: A F
authors.initials: AF
authors.lastname: Korystova
authors.forename: L N
authors.initials: LN
authors.lastname: Kublik
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Levitman
authors.forename: V V
authors.initials: VV
authors.lastname: Shaposhnikova
authors.forename: N O
authors.initials: NO
authors.lastname: Appazov
authors.forename: R A
authors.initials: RA
authors.lastname: Narmanova
authors.forename: S Zh
authors.initials: SZh
authors.lastname: Ibadullayeva
authors.forename: Yu N
authors.initials: YN
authors.lastname: Korystov
mesh_terms: D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000201:enzymology* / Q000473:pathology; D050197:Atherosclerosis / Q000517:prevention & control*; D044950:Flavanones / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D044950:Flavanones; D006027:Glycosides; D010936:Plant Extracts; C553320:camel thorn distillate; D011794:Quercetin; C003377:taxifolin; D019001:Nitric Oxide Synthase; D007703:Peptidyl-Dipeptidase A