title: LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis.
abstract: OBJECTIVE
  Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis.
  
  
  METHODS
  A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables.
  
  
  RESULTS
  Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP.
  
  
  CONCLUSIONS
  Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.
authors.affiliation: Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.
authors.forename: Chan Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Kwon
authors.forename: Yung Ly
authors.initials: YL
authors.lastname: Kim
authors.forename: Kyoung Sook
authors.initials: KS
authors.lastname: Park
authors.forename: Han Jak
authors.initials: HJ
authors.lastname: Ryu
authors.forename: Hyung Jung
authors.initials: HJ
authors.lastname: Oh
authors.forename: Seung Hyeok
authors.initials: SH
authors.lastname: Han
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Yoo
authors.forename: Yong-Lim
authors.initials: YL
authors.lastname: Kim
authors.forename: Yon Su
authors.initials: YS
authors.lastname: Kim
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
authors.forename: Nam-Ho
authors.initials: NH
authors.lastname: Kim
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Jung Tak
authors.initials: JT
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL