title: Relationship between submaximal oxygen uptake, detailed body composition, and resting energy expenditure in overweight subjects.
abstract: OBJECTIVE
  We investigated the impact of detailed body composition on aerobic fitness to determine whether regional components of fat mass have independent effects on VO2submax , and whether VO2submax and detailed body composition independently explain variation in REE.
  
  
  METHODS
  71 healthy adults (80% female, 20% male, BMI 28.2-43.8 kg/m(2) ) were investigated. Body composition was measured by the four-compartment model together with whole body magnetic resonance imaging (MRI) to assess high and low metabolic rate organs and regional fat depots. VO2submax was estimated at 75% of predicted maximum heart rate.
  
  
  RESULTS
  There was a strong association between VO2submax and FFM and all organ masses except for heart. Skeletal muscle mass accounted for 34.8% of the variance in VO2submax . In addition, subcutaneous adipose tissue (SAT) of extremities explained additional 14.4%. FFM and FM explained 71.3% of the variance in REE. Including the components of FFM and FM, the explained variance in REE increased by about 5.8%; skeletal muscle mass explained 70.0% of the variance in REE and kidney and liver masses explained additional 7.1%. VO2submax correlated with REE. Taking into account body composition, VO2submax did not add to the variance in REE.
  
  
  CONCLUSIONS
  FFM is a determinant of both VO2submax and REE. Modeling either REE or VO2submax from individual components of FFM, about 77.1% of variance in REE (by muscle, liver and kidneys mass) and 34.8% of variance in VO2submax (by skeletal muscle mass) could be explained. FM explained additional variance in REE, whereas SAT of extremities added to the variance in VO2submax only.
authors.affiliation: Institute of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany.
authors.forename: Maryam
authors.initials: M
authors.lastname: Pourhassan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Eggeling
authors.forename: Britta
authors.initials: B
authors.lastname: Schautz
authors.forename: Maike
authors.initials: M
authors.lastname: Johannsen
authors.forename: Dieter
authors.initials: D
authors.lastname: Kiosz
authors.forename: Claus-Christian
authors.initials: CC
authors.lastname: Glüer
authors.forename: Anja
authors.initials: A
authors.lastname: Bosy-Westphal
authors.forename: Manfred James
authors.initials: MJ
authors.lastname: Müller
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D050177:Overweight / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010809:Physical Fitness / Q000502:physiology; D012146:Rest / Q000502:physiology*
chemical_list: D010100:Oxygen