title: Successful HLA haploidentical myeloablative stem cell transplantation for aggressive hepatosplenic alpha/beta (αβ) T-cell lymphoma.
abstract: Hepatosplenic T cell lymphoma (HSTCL) is a type of hematologic neoplasia with a poor prognosis and a high frequency of refractoriness to conventional chemotherapy. The results obtained by high dose chemotherapy followed by autologous stem cells transplantation seem to be a more effective option but still unsatisfactory. Also the role of allogeneic stem cell transplantation is still unclear, although the few cases reported on the literature would seem to show good results in overall survival rates. In this paper, we reported the patient׳s medical history affected by a αβ variant of hepatosplenic T cell successfully rescued with a haploidentical transplant.
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Catania
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Zallio
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Monaco
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Corsetti
authors.affiliation: Division of Anatomic-Pathology, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Nicol
authors.initials: N
authors.lastname: Trincheri
authors.affiliation: Department of Pathology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Bonello
authors.affiliation: Divison of Transfusion Medicine, A.O. SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Lia
authors.initials: L
authors.lastname: Mele
authors.affiliation: Divison of Transfusion Medicine, A.O. SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Dallavalle
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Salvi
authors.affiliation: Hematology and Marrow Transplant, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Pini
keywords: Haploidentical-SCT; Hepatosplenic T-cell lymphoma; TCR rearrangement; αβ T-lymphocytes