title: Gold-catalyzed spiro-N,O-ketal synthesis.
abstract: An efficient method for the synthesis of spiro-N,O-ketals with 5- and 6-membered rings was developed via a gold-catalyzed spiroamidoketalization of alkynyl amidoalcohols under mild conditions. This methodology has been successfully applied to the synthesis of a spiro-N,O-ketal analogue of marineosin A.
authors.affiliation: Faculty of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. sarli@chem.auth.gr.
authors.forename: M
authors.initials: M
authors.lastname: Grammatikopoulou
authors.forename: S
authors.initials: S
authors.lastname: Thysiadis
authors.forename: V
authors.initials: V
authors.lastname: Sarli
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006046:Gold / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D013141:Spiro Compounds; D006046:Gold