title: The characteristics of neuronal stem cells of central neurocytoma.
abstract: Angiographic findings suggest that central neurocytoma (CN) might originate from neuronal cells of the subventricular zone (SVZ) around the foramen of Monro rather than from the septum pellucidum. The majority of CN cells have neuroblast characteristics. Most importantly, CN-derived tumor spheres have a phenotype of transit-amplifying type C cells, implying that these cells might arise from transformed transit-amplifying type C cells that reside in the SVZ. These CN-derived tumor spheres are also reminiscent of radial glial cells. Immunohistochemical and electrophysiologic studies show that these cells exhibit bipotential neuroglial differentiation in vitro.
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Shin
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. Electronic address: paeksh@snu.ac.kr.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dong Gyu
authors.initials: DG
authors.lastname: Kim
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D006801:Humans; D058953:Neural Stem Cells / Q000473:pathology*; D018306:Neurocytoma / Q000473:pathology*
keywords: Cancer stem cell; Central neurocytoma; Histogenesis; Neuronal differentiation; Subventricular zone