title: Use of everolimus in renal transplant recipients: data from a national registry.
abstract: Proliferation signal inhibitors, such as everolimus, offer immunosuppression without the toxicity of calcineurin inhibitors. This descriptive and prospective study reports outcomes at 1 year and predictors of improved estimated glomerular filtration rate (eGFR) in 174 renal transplant recipients from a national registry of the use of everolimus. At 1 year after conversion, 48.85% of patients had improved eGFR compared with baseline. The mean time from transplantation to initiation of treatment with everolimus was 47.97 months, the median 22 (range, 0-312) months. The kidneys were from deceased donors in 120 patients (68.79%) and from living donors in 54 (31.21%); 35 (20.83%) were expanded-criteria donors. When comparing the baseline versus 12-month values of laboratory results, total cholesterol levels and platelet counts differed significantly-191.55 ± 43.92 mg/dL versus 204.52 ± 41.29 mg/dL (P < .05) and 213,411 ± 63,231/mm(3) vs 255,571 ± 59,153/mm(3), respectively (P < .05)-but remained within clinically controllable ranges. Glycemia, triglycerides, hematocrit, hemoglobin, and leukocytes remained stable. Logistic regression analysis of baseline variables showed that the only independent prognostic factor for improved eGFR at 1 year was the conversion of patients to everolimus within the first 12 months after transplantation (odds ratio, 2.17; 95% confidence interval, 1.15-4.10). In conclusion, regarding the effectiveness of everolimus in our subjects, the only predictor of improved eGFR identified at 1 year was conversion within 12 months after transplantation.
authors.affiliation: Renal Transplant, Hospital Alemán, Buenos Aires, Argentina; Foundation for Research and Assistance of Renal Disease, Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Cicora
authors.affiliation: Renal Transplant, Hospital Privado Córdoba, Córdoba, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Massari
authors.affiliation: Renal Transplant, Hospital Provincial Centenario de Rosario, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Acosta
authors.affiliation: Crai Sur Cucaiba, La Plata, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Petrone
authors.affiliation: Instituto de Nefrología, Buenos Aires, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Cambariere
authors.affiliation: Renal Transplant, Hospital de Alta Complejidad J Perón, Formosa, Argentina.
authors.forename: I
authors.initials: I
authors.lastname: González
authors.affiliation: Renal Transplant, Hospital Italiano, Buenos Aires, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: Imperiali
authors.affiliation: Renal Transplant, Hospital JC Perrando, Resistencia, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: López
authors.affiliation: Novartis Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Otero
authors.affiliation: Foundation for Research and Assistance of Renal Disease, Buenos Aires, Argentina. Electronic address: javierroberti@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Roberti
mesh_terms: D000328:Adult; D000068338:Everolimus; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus