title: Geroscience: linking aging to chronic disease.
abstract: Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
authors.affiliation: Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Shelley L
authors.initials: SL
authors.lastname: Berger
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
authors.affiliation: Buck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.affiliation: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Cuervo
authors.affiliation: Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.
authors.forename: Elissa S
authors.initials: ES
authors.lastname: Epel
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.affiliation: Buck Institute for Research on Aging, Novato, CA USA.
authors.forename: Gordon J
authors.initials: GJ
authors.lastname: Lithgow
authors.affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Richard I
authors.initials: RI
authors.lastname: Morimoto
authors.affiliation: Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Pessin
authors.affiliation: Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Rando
authors.affiliation: Donald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
authors.forename: Arlan
authors.initials: A
authors.lastname: Richardson
authors.affiliation: Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.
authors.forename: Eric E
authors.initials: EE
authors.lastname: Schadt
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
authors.affiliation: Division of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.
authors.forename: Felipe
authors.initials: F
authors.lastname: Sierra
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D035843:Biomedical Research; D002908:Chronic Disease; D044127:Epigenesis, Genetic; D059647:Gene-Environment Interaction; D006801:Humans