title: Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles.
abstract: We fabricated a simple yet robust microfluidic platform with monolithically integrated hierarchical apertures. This platform showed efficient diffusive mixing of the introduced lipids through approximately 8000 divisions with tiny pores (~5 μm in diameter), resulting in massive, real-time production of various cargo-carrying particles via multi-hydrodynamic focusing.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea. jhs@snu.ac.kr.
authors.forename: Hyesung
authors.initials: H
authors.lastname: Cho
authors.forename: Junsoo
authors.initials: J
authors.lastname: Kim
authors.forename: Keishi
authors.initials: K
authors.lastname: Suga
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ishigami
authors.forename: Hyunchul
authors.initials: H
authors.lastname: Park
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Bang
authors.forename: Soonmin
authors.initials: S
authors.lastname: Seo
authors.forename: Mansoo
authors.initials: M
authors.lastname: Choi
authors.forename: Pahn-Shick
authors.initials: PS
authors.lastname: Chang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Umakoshi
authors.forename: Ho-Sup
authors.initials: HS
authors.lastname: Jung
authors.forename: Kahp-Yang
authors.initials: KY
authors.lastname: Suh
mesh_terms: D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004867:Equipment Design; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D057446:Hydrodynamics; D008027:Light; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D012542:Scattering, Radiation
chemical_list: C493048:10, 12-pentacosadiynoic acid; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008081:Liposomes; D004134:Dimyristoylphosphatidylcholine