title: Penile erectile dysfunction after brachial plexus root avulsion injury in rats.
abstract: Our previous studies have demonstrated that some male patients suffering from brachial plexus injury, particularly brachial plexus root avulsion, show erectile dysfunction to varying degrees. However, the underlying mechanism remains poorly understood. In this study, we evaluated the erectile function after establishing brachial plexus root avulsion models with or without spinal cord injury in rats. After these models were established, we administered apomorphine (via a subcutaneous injection in the neck) to observe changes in erectile function. Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation. Expression of neuronal nitric oxide synthase did not change in brachial plexus root avulsion rats. However, neuronal nitric oxide synthase expression was significantly decreased in brachial plexus root avulsion + spinal cord injury rats. These findings suggest that a decrease in neuronal nitric oxide synthase expression in the penis may play a role in erectile dysfunction caused by the combination of brachial plexus root avulsion and spinal cord injury.
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Fu
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Bengang
authors.initials: B
authors.lastname: Qin
authors.affiliation: Orthopedic Institute, Eastern Hospital, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Upper Limb Orthopedics, Eastern Hospital, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Xijun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Emergency Department, Shandong Provincial Hospital, Jinan, Shandong Province, China.
authors.forename: Qinsen
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Orthopedics, the Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong Province, China.
authors.forename: Dechun
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Jiakai
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Office of Research Service, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Xuejia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopedic Trauma & Microsurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Gu
keywords: brachial plexus avulsion; erectile dysfunction; nerve regeneration; neural regeneration; neuronal nitric oxide synthase; penis; peripheral nerve injury; rat model; spinal cord injury