title: Usefulness of the platelet-to-lymphocyte ratio in predicting bare-metal stent restenosis.
abstract: OBJECTIVE
  Platelet-to-lymphocyte ratio (PLR) provides a simple method for assessment of inflammatory status. The aim of the present study was to investigate the predictive value of preprocedural PLR on development of in-stent restenosis in patients undergoing bare-metal stent (BMS) implantation.
  
  
  METHODS
  Six hundred and seventy-five consecutive patients (mean age: 60.6 ± 8.3, 66% men) who had undergone successful BMS implantation and additional coronary angiography for stable or unstable angina pectoris were analyzed. Mean period between 2 coronary angiographies was 14.3 ± 3.4 months.
  
  
  RESULTS
  Patients were divided into tertiles based on preprocedural PLR. Restenosis occurred in 58 patients (26%) in the lowest tertile, in 82 (36%) in the middle tertile, and in 115 (51%) in the highest tertile (p < 0.001). Serum C-reactive protein levels were also significantly higher in patients in tertile 3 than in those in tertiles 1 and 2 (p < 0.001). Smoking, diabetes mellitus, high-density lipoprotein, stent length, preprocedural PLR, and C-reactive protein levels emerged as independent predictors of in-stent restenosis. In receiver-operating characteristics curve analysis, PLR >122 had 81% sensitivity and 72% specificity in predicting in-stent restenosis.
  
  
  CONCLUSIONS
  High preprocedural PLR is a powerful and independent predictor of BMS restenosis in patients with stable and unstable angina pectoris.
authors.affiliation: Cardiology clinic, Turkey Yuksek Ihtisas Education and Research Hospital , Ankara , Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Yılmaz
authors.forename: Fatıh
authors.initials: F
authors.lastname: Sen
authors.forename: Sefa
authors.initials: S
authors.lastname: Ünal
authors.forename: Cağri
authors.initials: C
authors.lastname: Yayla
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Özeke
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloglu
authors.forename: Sınan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D019540:Area Under Curve; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008670:Metals; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome
chemical_list: D008670:Metals
keywords: coronary artery disease; inflammation; stent restenosis