title: Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water.
abstract: 2-Dihydroquinazolin-4(1H)-thiones were prepared in up to excellent yields from 2-aminobenzothioamides and aldehydes. The reaction is carried out in water without the use of any catalyst or promoter. The sulfur-containing substrate can be obtained easily by thiation of the corresponding nitrile by solid sodium hydrosulfide.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany. xiao-feng.wu@catalysis.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Oschatz
authors.forename: Tom
authors.initials: T
authors.lastname: Brunzel
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013854:Thioamides / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D011799:Quinazolines; D013854:Thioamides; D014867:Water