title: Survival analysis tools in genomics research.
abstract: There is an increasing demand to determine the clinical implication of experimental findings in molecular biomedical research. Survival (or failure time) analysis methodologies have been adapted to the analysis of genomics data to link molecular information with clinical outcomes of interest. Genome-wide molecular profiles have served as sources for discovery of predictive/prognostic biomarkers as well as therapeutic targets in the past decade. In this review, we overview currently available software, web applications, and databases specifically developed for survival analysis in genomics research and discuss issues in assessing clinical utility of molecular features derived from genomic profiling.
authors.affiliation: Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Box 1123, New York, NY, 10029, USA. xintong.chen@mssm.edu.
authors.forename: Xintong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Box 1123, New York, NY, 10029, USA. xiaochen.sun@mssm.edu.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Sun
authors.affiliation: Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Box 1123, New York, NY, 10029, USA. yujin.hoshida@mssm.edu.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Hoshida
mesh_terms: D035843:Biomedical Research; D016208:Databases, Factual; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D056726:Genetic Association Studies / Q000379:methods; D005819:Genetic Markers; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012984:Software; D016019:Survival Analysis
chemical_list: D005819:Genetic Markers