title: Glycerol affects vestibular-evoked myogenic potentials and pure-tone hearing in patients with Ménière's disease.
abstract: CONCLUSIONS
  The pure-tone audiometry results following glycerol administration indicated a positive effect on cochlear endolymphatic hydrops. Glycerol cervical vestibular-evoked myogenic potential (cVEMP) tests are a useful means of diagnosing saccular hydrops. There was no correlation between cVEMP and audiological results.
  
  
  OBJECTIVE
  To document the changes in pure-tone hearing outcomes and cVEMPs in patients with Ménière's disease (MD) and 10 healthy volunteers before and after oral administration of glycerol.
  
  
  METHODS
  Twenty-nine study group subjects were chosen with complaints of vertigo. cVEMP testing and pure-tone hearing level testing were performed before and at 1, 2, and 3 h after administration of glycerol.
  
  
  RESULTS
  The means of the latencies, amplitudes, and difference ratio in 20 normal subject ears were determined. Based on these values, 9/29 MD-affected (MDA) ears (31%) had a unilaterally absent cVEMP. Compared with difference ratio values of the control groups there were significant differences in both latencies and amplitudes in MDA ears after glycerol administration. Before glycerol administration, there were significant differences between control and MDA ears on mean values of pure-tone hearing outcomes. Twenty patients in the MDA group showed significant pure-tone hearing outcomes after glycerol administration.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Baskent University , Ankara , Turkey.
authors.forename: Isilay
authors.initials: I
authors.lastname: Oz
authors.forename: Seyra Hatice
authors.initials: SH
authors.lastname: Erbek
authors.forename: Gulfem
authors.initials: G
authors.lastname: Alp
authors.forename: Evren
authors.initials: E
authors.lastname: Hizal
authors.forename: Levent Naci
authors.initials: LN
authors.lastname: Ozluoglu
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D005260:Female; D005990:Glycerol; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D012997:Solvents; D058585:Vestibular Evoked Myogenic Potentials / Q000187:drug effects*
chemical_list: D012997:Solvents; D005990:Glycerol
keywords: Glycerol test; endolymphatic hydrops; hearing outcome; vertigo