title: Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.
abstract: OBJECTIVE
  To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC).
  
  
  METHODS
  We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed.
  
  
  RESULTS
  A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status (p < 0.001), nodal status (p = 0.008) and cathepsin-D (p < 0.001) were retained to construct the nomogram (C-index 0.734).
  
  
  CONCLUSIONS
  The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC.
authors.affiliation: Laboratoire de Transfert d'oncologie Biologique, Faculté de Médecine Nord, Assistance Publique - Hôpitaux de Marseille, Marseille, France, chafika.mazouni@gustaveroussy.fr.
authors.forename: Chafika
authors.initials: C
authors.lastname: Mazouni
authors.forename: Frédéric
authors.initials: F
authors.lastname: Fina
authors.forename: Sylvie
authors.initials: S
authors.lastname: Romain
authors.forename: Pascal
authors.initials: P
authors.lastname: Bonnier
authors.forename: L'houcine
authors.initials: L
authors.lastname: Ouafik
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Martin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D002402:Cathepsin D / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000517:prevention & control; D049451:Nomograms; D011184:Postoperative Period; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011980:Receptors, Progesterone; D002402:Cathepsin D