title: Radiolabeling in Biology.
abstract: Chemistry is the science of chemical reactions, the study of chemical properties, composition, and structure of a molecule. When the molecule under observation is of a biological origin (proteins, carbohydrates, lipids, or nucleic acids), the study of its chemical properties, reactions, and structure is known as biochemistry. Similarly, if the molecule or a biochemical under observation is radioactive, the science becomes radiochemistry or radio biochemistry. So, chemistry is the science which fuses these two diverse fields of applied sciences. Fusion of these two sciences on chemistry platform has enabled the development of various new radioactive formulations which are called as radiopharmaceuticals and are being used the world over for clinical as well as experimental purposes. For the successful development of radiopharmaceuticals, we require in-depth understanding of both biochemistry as well as radiochemistry. So, the present review article summarizes basic relevant details and experimental advances in both these sciences with regard to development of radiopharmaceuticals.
authors.affiliation: National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
authors.forename: Yangde
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biophysics, Post Graduate Institute of Medical Education and Research, Room No 525, Research Block B, Chandigarh, 160012, India. anshoo.malhotra@gmail.com.
authors.forename: Anshoo
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D002855:Chromatography, Thin Layer; D004586:Electrophoresis; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D051379:Mice; D009841:Oligonucleotides / Q000737:chemistry; D009994:Osmolar Concentration; D010100:Oxygen / Q000737:chemistry; D004369:Pentetic Acid / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D011786:Quality Control; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000737:chemistry*; D051381:Rats; D013667:Technetium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D008024:Ligands; D008055:Lipids; D009841:Oligonucleotides; D010455:Peptides; D011506:Proteins; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D013667:Technetium; D004369:Pentetic Acid; D010100:Oxygen
keywords: 99mTc; Ligand; Radiopharmaceuticals