title: Are all patients with psoriasis at increased risk for coronary artery disease?
abstract: Associations have been recently recognized between psoriasis and an increased incidence of atherosclerotic diseases. However, there are scarce data on the prevalence of coronary lesions in patients with psoriasis. The aim of this study was to identify the calcified and non-calcified atherosclerotic coronary lesions in patients with psoriasis compared to controls. Forty patients with psoriasis and 42 control subjects matched for age, sex, and cardiovascular risk profile were included in this case-control study. Coronary lesions were evaluated by a 128-slice dual source multidetector computed tomography scanner. Coronary calcification scoring was calculated according to the Agatston score. The prevalence of atherosclerotic coronary lesions (psoriasis: 15%, controls: 16.7%; P = 0.83) and the mean coronary calcification scoring (psoriasis: 9.9 ± 35.2 Agatston unit, controls 2.8 ± 12.0 Agatston unit; P = 0.81) did not show a significant difference between the two groups. Multivariate analysis identified age ≥48 years and fasting blood glucose ≥99.0 mg/dl as independent predictors of coronary artery disease in patients with psoriasis (F = 30.9; P = 0.001; adjusted R(2) = 0.49). Patients with psoriasis had the same prevalence of calcified and non-calcified atherosclerotic coronary lesions as compared to controls. Our results demonstrated the necessity of considering the age and fasting blood glucose of patients with psoriasis in a decision for further cardiovascular evaluation.
authors.affiliation: Department of Dermatology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Sila
authors.initials: S
authors.lastname: Seremet
authors.forename: Berhan
authors.initials: B
authors.lastname: Genc
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tastan
authors.forename: Zehra Ilke
authors.initials: ZI
authors.lastname: Akyildiz
authors.forename: Cem
authors.initials: C
authors.lastname: Nazli
authors.forename: Sinan
authors.initials: S
authors.lastname: Ozcelik
authors.forename: Fatma Sule
authors.initials: FS
authors.lastname: Afsar
authors.forename: Aynur
authors.initials: A
authors.lastname: Solak
authors.forename: Volkan
authors.initials: V
authors.lastname: Emren
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D016022:Case-Control Studies; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015995:Prevalence; D011565:Psoriasis / Q000097:blood / Q000453:epidemiology*; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D003287:Contrast Media; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human