title: Cu(I)-catalyzed transannulation of N-heteroaryl aldehydes or ketones with alkylamines via C(sp3)-H amination.
abstract: A copper(I)-catalyzed direct transannulation of N-heteroaryl aldehydes or ketones with alkylamines via Csp(3)-H amination has been achieved using molecular oxygen as a sole oxidant. N-Heteroarenes are employed as the amine source. This transformation provides a rapid and concise access to multifunctional imidazo[1,5-a]pyridines.
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technolgy, Guangzhou 510641, China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Li
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technolgy, Guangzhou 510641, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technolgy, Guangzhou 510641, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ye
authors.affiliation: ‡School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zou
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technolgy, Guangzhou 510641, China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: †School of Chemistry and Chemical Engineering, South China University of Technolgy, Guangzhou 510641, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006574:Heterocyclic Compounds, 2-Ring; D007093:Imidazoles; D007454:Iodides; D007659:Ketones; D011725:Pyridines; D003300:Copper; C073870:cuprous iodide