title: Community resources and technologies developed through the NIH Roadmap Epigenomics Program.
abstract: This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.
authors.affiliation: Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, NIH, MSC 9555, Bethesda, MD, 20892-9555, USA, satterleej@nida.nih.gov.
authors.forename: John S
authors.initials: JS
authors.lastname: Satterlee
authors.forename: Andrea
authors.initials: A
authors.lastname: Beckel-Mitchener
authors.forename: Kim
authors.initials: K
authors.lastname: McAllister
authors.forename: Dena C
authors.initials: DC
authors.lastname: Procaccini
authors.forename: Joni L
authors.initials: JL
authors.lastname: Rutter
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Tyson
authors.forename: Lisa Helbling
authors.initials: LH
authors.lastname: Chadwick
mesh_terms: D000818:Animals; D057890:Epigenomics / Q000379:methods*; D005821:Genetic Techniques; D006295:Health Resources; D006801:Humans; D009316:National Institutes of Health (U.S.); D012111:Residence Characteristics; D014481:United States