title: Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.
abstract: Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19103, USA.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Vargo
authors.forename: Ajlan Al
authors.initials: AA
authors.lastname: Zaki
authors.forename: Robert
authors.initials: R
authors.lastname: Warden-Rothman
authors.forename: Andrew
authors.initials: A
authors.lastname: Tsourkas
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Hammer
mesh_terms: D016475:3T3 Cells; D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008823:Micelles; D010940:Plant Proteins / Q000737:chemistry* / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000493:pharmacokinetics*; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D003287:Contrast Media; D003911:Dextrans; D005079:Excipients; D058185:Magnetite Nanoparticles; D008823:Micelles; D010940:Plant Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011994:Recombinant Proteins; C097921:ferumoxtran-10; C508053:ERBB2 protein, human
keywords: MRI contrast; contrast agents; iron oxide; oleosin; recombinant surfactants; targeting