title: Organ-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain.
abstract: Theiler's murine encephalomyelitis virus (TMEV) can induce demyelination or myocarditis in susceptible mouse strains. A deficiency of NKT cells exacerbated TMEV-induced demyelinating disease (TMEV-IDD) in SJL/J and BALB/c mice. In C57BL/6 background, however, NKT-cell-deficient Jα18 KO mice remained as resistant to TMEV-IDD as wild-type mice. Echocardiography and histology showed that Jα18 KO mice developed more severe myocarditis (greater T cell infiltration and fibrosis) than wild-type mice, suggesting a protective role of NKT cells in myocarditis in C57BL/6 mice. Jα18 KO mice had higher cardiac viral RNA and anti-viral antibody titers, but had lower lymphoproliferation and IL-4 and IL-10 production.
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Kawai
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Sato
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Omura
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Martinez
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Pratap C
authors.initials: PC
authors.lastname: Reddy
authors.affiliation: Laboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Taniguchi
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA. Electronic address: itsuno@lsuhsc.edu.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tsunoda
mesh_terms: D000367:Age Factors; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000494:pharmacology; D018188:Cardiovirus Infections / Q000150:complications* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000473:pathology / Q000821:virology; D016207:Cytokines / Q000378:metabolism; D003711:Demyelinating Diseases / Q000209:etiology* / Q000821:virology; D005355:Fibrosis / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology / Q000821:virology; D055611:Natural Killer T-Cells / Q000502:physiology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency / Q000235:genetics / Q000276:immunology; D013045:Species Specificity; D017945:Theilovirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D000906:Antibodies; D016207:Cytokines; D016693:Receptors, Antigen, T-Cell, alpha-beta
keywords: CNS demyelinating disease; GDVII strain; Multiple sclerosis; Picornaviridae infection; Seizure; Tropism