title: Association study of the SLITRK5 gene and Tourette syndrome.
abstract: Tourette syndrome (TS) and obsessive-compulsive disorder commonly occur together. Family studies indicate shared genetic risk factors. SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine. In this study, we tested the SLITRK5 gene as a candidate for TS in a family-based sample with 377 affected children. Using single nucleotide polymorphisms tagging the gene, we did not find any evidence supporting the association of TS and SLITRK5.
authors.affiliation: aGenetics and Development Division bDivision of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network cProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.forename: Karen G
authors.initials: KG
authors.lastname: Wigg
authors.forename: Paul
authors.initials: P
authors.lastname: Sandor
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Barr
mesh_terms: D000818:Animals; D002648:Child; D005192:Family Health; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D005879:Tourette Syndrome / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C550141:Slitrk5 protein, mouse