title: [Comparison of caffeine citrate and aminophylline for treating primary apnea in premature infants].
abstract: OBJECTIVE
  To investigate the clinical efficacy and safety of caffeine citrate and aminophylline in the treatment of primary apnea in premature infants.
  
  
  METHODS
  The clinical data of 125 premature infants with primary apnea from March 2013 to March 2014 were retrospectively analyzed. According to the therapeutic strategy, the patients were divided into caffeine citrate group (n=65) and aminophylline group (n=60). The overall response rates and adverse reaction rates in the two groups were compared.
  
  
  RESULTS
  The overall response rate in the caffeine citrate group was 86% (56 cases), which was significantly higher than that in the aminophylline group (72%, 43 cases) (P<0.05). The adverse reactions in the caffeine citrate group included tachycardia (1 case), restlessness (5 cases), feeding intolerance (7 cases), electrolyte disturbance (2 cases), and high blood glucose (5 cases), the incidence of which was significantly lower than that in the aminophylline group (P<0.05).
  
  
  CONCLUSIONS
  Caffeine citrate is more effective and causes fewer adverse reactions than aminophylline in the treatment of primary apnea in premature infants.
authors.affiliation: Department of Neonatology, Children's Hospital of Quanzhou, Quanzhou, Fujian 362000, China. 363142715@qq.com.
authors.forename: Jing-Lin
authors.initials: JL
authors.lastname: Xu
authors.forename: Rui-Quan
authors.initials: RQ
authors.lastname: Wang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Chen
mesh_terms: D000628:Aminophylline / Q000009:adverse effects / Q000627:therapeutic use*; D001049:Apnea / Q000188:drug therapy*; D002110:Caffeine / Q000009:adverse effects / Q000627:therapeutic use*; D002951:Citrates / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012189:Retrospective Studies
chemical_list: D002951:Citrates; D000628:Aminophylline; D002110:Caffeine; C026189:caffeine citrate