title: HIV-1 Packing to Leave.
abstract: HIV-1 virion assembly at the plasma membrane requires the selective recruitment of the viral RNA genome into nascent viral particles while cellular transcripts are excluded. Kutluay et al. now demonstrate that this is a two-step process in which Gag binds sequentially to different sites on the viral genome.
authors.affiliation: Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: bryan.cullen@duke.edu.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Cullen
mesh_terms: D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D012367:RNA, Viral / Q000378:metabolism*; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus