title: Osteonecrosis of the jaw in patient with denosumab therapy.
abstract: Osteonecrosis (ON) of the jaw has previously been linked to the use of biphosphonates; however, new drugs, also shown similar conditions. This article presents a female patient with mandibular ON related to the use of denosumab. The 55-year-old presented with bone exposure with 8 months of evolution after a dental extraction. The patient began subcutaneous injections of 60 mg denosumab four months prior to the extraction and the lesion remained after the procedure. The patient, with 14 months of follow-up, show mandible ON with no favorable evolution. The clinical condition is presented and the literature of ON associated with denosumab is discussed.
authors.affiliation: Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile ; Center for Biomedical Research, Universidad Autónoma de Chile Chile.
authors.forename: Sergio
authors.initials: S
authors.lastname: Olate
authors.affiliation: Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile ; Programa de Doctorado en Ciencias Médicas, Universidad de La Frontera Chile.
authors.forename: Francisca
authors.initials: F
authors.lastname: Uribe
authors.affiliation: Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Martinez
authors.affiliation: Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile.
authors.forename: Andrés
authors.initials: A
authors.lastname: Almeida
authors.affiliation: Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile ; Programa de Magister en Ciencias Odontológicas, Universidad de La Frontera Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Unibazo
keywords: Denosumab; cancer therapy; osteonecrosis