title: Prognostic value of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and multiphasic renal tomography findings in histological subtypes of renal cell carcinoma.
abstract: BACKGROUND
  To determine the relationship between renal cell carcinoma subtypes and the associated mortality and biochemical parameters. An additional aim was to analyze multiphasic multidetector computed tomography findings.
  
  
  METHODS
  This study is a hospital-based retrospective investigation, using 211 patients with a diagnosis of renal cell carcinoma upon computed tomography examination. The histological subtypes included clear cell in 119 patients, chromophobe cell in 30 patients, papillary cell in 25 patients, mixed cell in 32 patients, and sarcomatoid cell in 4 patients.
  
  
  RESULTS
  The mean age of the patients participating in this study was 61.18 ± 11.81 years, and the mortality rate was 10.4% (n = 22) through the 2-year follow-up. The ratios of both the neutrophil-to-lymphocyte upon admission to the hospital and platelet-to-lymphocyte of the non-surviving group were significantly higher than those of the surviving group (p < 0.05). When the analysis of the 2-year survival of the patients was examined according to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups (p = 0.01). In two-way analysis of variance test, statistically significant results which were influenced by mortality (p = 0.028) and were found between renal cell carcinoma subtypes in the computed tomography density of corticomedullary phase (p = 0.001).
  
  
  CONCLUSIONS
  The neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio may represent widely available biomarkers in renal cell carcinoma, and the logistic regression model indicated that neutrophil-to-lymphocyte ratio was a significant predictor for mortality. According to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups.
authors.affiliation: Department of Radiology, Necmettin Erbakan University, Meram School of Medicine, Beyşehir Street, Akyokuş, Meram, Konya 42080, Turkey. drsuatkeskin@yahoo.com.
authors.forename: Suat
authors.initials: S
authors.lastname: Keskin
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Keskin
authors.forename: Hakan Hakki
authors.initials: HH
authors.lastname: Taskapu
authors.forename: Havva
authors.initials: H
authors.lastname: Kalkan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kaynar
authors.forename: Necdet
authors.initials: N
authors.lastname: Poyraz
authors.forename: Hatice
authors.initials: H
authors.lastname: Toy
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality; D007958:Leukocyte Count; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D010976:Platelet Count; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor