title: The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration.
abstract: Reorganization of the actin cytoskeleton is essential for cell motility and chemotaxis. Actin-binding proteins (ABPs) and membrane lipids, especially phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 are involved in the regulation of this reorganization. At least 15 ABPs have been reported to interact with, or regulated by phosphoinositides (PIPs) whose synthesis is regulated by extracellular signals. Recent studies have uncovered several parallel intracellular signalling pathways that crosstalk in chemotaxing cells. Here, we review the roles of ABPs and phosphoinositides in chemotaxis and cell migration.
  
  
  BACKGROUND
  This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-24.
authors.affiliation: Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Wu
authors.forename: M-W
authors.initials: MW
authors.lastname: Lin
authors.forename: D-C
authors.initials: DC
authors.lastname: Wu
authors.forename: Y-B
authors.initials: YB
authors.lastname: Huang
authors.forename: H-T
authors.initials: HT
authors.lastname: Huang
authors.forename: C-L
authors.initials: CL
authors.lastname: Chen
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008840:Microfilament Proteins; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; D051059:PTEN Phosphohydrolase