title: One-dose vaccination associated with attenuated disease severity of adolescent and adult varicella cases in Beijing's Fengtai District.
abstract: BACKGROUND
  In recent years, the number of varicella cases in adults has significantly increased in Beijing. However, the effect of the vaccination on varicella-related characteristics among adults has not been studied.
  
  
  RESULTS
  Using data from the Infectious Disease Reporting System and the Immunization Information System, we compared the epidemiology and disease severity in breakthrough and unvaccinated varicella cases in adolescents and adults (≥ 15 year-old) from 2008 to 2011 in Beijing's Fengtai district, China. The results showed that the age (P = 0.003),contact history (90% vs. 73%, P = 0.019) and outbreak cases (10% vs. 1%, P < 0.0001) were significantly differently distributed between the two groups and that both the incidence of moderate-to-severe cases (26% vs. 45%, P = 0.035, OR = 0.446) and varicella-associated fever (49% vs. 66%, P = 0.068, OR = 0.534) were either significantly lower or trended to be lower in the breakthrough group than in the unvaccinated group. Additionally,vaccine effectiveness against moderate-to-severe cases of varicella was 55.4%.
  
  
  CONCLUSIONS
  Altogether, these results indicate that vaccination against varicella among adolescents and adults affected the epidemiology and attenuated the disease severity of the cases. The Results from this study will provide useful information for the prevention of varicella in adolescents and adults.
authors.affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Capital Medical University;  2. Fengtai Center for Disease Control and Prevention; Beijing, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuncui
authors.initials: Y
authors.lastname: Yu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Edwin P
authors.initials: EP
authors.lastname: Kwan
authors.forename: Shengtian
authors.initials: S
authors.lastname: Huang
authors.forename: Zhongzhan
authors.initials: Z
authors.lastname: Wang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Peng
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Luo
authors.forename: Shujing
authors.initials: S
authors.lastname: Han
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.forename: Guangxue
authors.initials: G
authors.lastname: Liu
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D002644:Chickenpox / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D019433:Chickenpox Vaccine
keywords: adolescents; adults; bacterial; breakthrough; epidemiology; infectious disease; vaccination; vaccine; varicella