title: [Positron emission tomography combined with computed tomography in the initial evaluation and response assessment in primary central nervous system lymphoma].
abstract: OBJECTIVE
  To evaluate the role of positron emission tomography combined with computed tomography (PET-CT) in the initial evaluation and response assessment in primary central nervous system lymphoma (PCNSL).
  
  
  METHODS
  Fourteen patients (8 males) with a median age 59.5 years diagnosed of PCNSL. A brain PET-CT and magnetic resonance imaging (MRI) were performed in the initial evaluation. In 7 patients a PET-CT after treatment was performed.
  
  
  RESULTS
  PET-CT showed at diagnosis 31 hypermetabolic focuses and MRI showed 47 lesions, with a good grade of concordance between both (k = 0.61; P = .005). In the response assessment, correlation between both techniques was good, and PET-CT was helpful in the appreciation of residual MRI lesions. Overall survival at 2 years of negative vs. positive PET-CT at the end of treatment was 100 vs. 37.5%, respectively (P = .045).
  
  
  CONCLUSIONS
  PET-CT can be useful in the initial evaluation of PCNSL, and especially in the assessment of response. Despite the fact that PET-CT detects less small lesions than MRI, a good correlation between MRI and PET-CT was observed. It is effective in the evaluation of residual lesions. Prospective studies are needed to confirm their possible prognostic value.
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia, Hospital Duran i Reynals, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España. Electronic address: smercadal@iconcologia.net.
authors.forename: Santiago
authors.initials: S
authors.lastname: Mercadal
authors.affiliation: Unidad PET-TC, Institut de Diagnòstic per la Imatge (IDI), Hospital Universitario de Bellvitge, L'Hospitalet del Llobregat, Barcelona, España.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Cortés-Romera
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia, Hospital Duran i Reynals, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Patricia
authors.initials: P
authors.lastname: Vélez
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Fina
authors.initials: F
authors.lastname: Climent
authors.affiliation: Unidad PET-TC, Institut de Diagnòstic per la Imatge (IDI), Hospital Universitario de Bellvitge, L'Hospitalet del Llobregat, Barcelona, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gámez
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia, Hospital Duran i Reynals, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Eva
authors.initials: E
authors.lastname: González-Barca
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D016411:Lymphoma, T-Cell, Peripheral / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate
keywords: Linfoma cerebral primario; Magnetic resonance; Positron emission tomography combined with computed tomography; Primary central nervous system lymphoma; Prognosis; Pronóstico; Resonancia magnética; Tomografía por emisión de positrones combinada con tomografía computarizada