title: PD0332991 (palbociclib) for treatment of pediatric intracranial growing teratoma syndrome.
abstract: Growing teratoma syndrome is characterized by growth of mature teratoma elements of a mixed germ cell tumor despite resolution of immature/malignant elements with administration of chemotherapy. Surgical resection is the only known cure for growing teratoma syndrome but in the brain, complete resection may be impossible. In these instances, mature teratoma, although histologically benign, may be fatal. In this report, we present the case of a child with a large, rapidly growing, unresectable pineal region growing teratoma. PD0332991 was administered with stabilization of the solid, enhancing components of the mass. Minimal adverse effects were noted.
authors.affiliation: Cancer and Blood Disorders, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota.
authors.forename: Kris Ann P
authors.initials: KA
authors.lastname: Schultz
authors.forename: Joseph
authors.initials: J
authors.lastname: Petronio
authors.forename: Anne
authors.initials: A
authors.lastname: Bendel
authors.forename: Richard
authors.initials: R
authors.lastname: Patterson
authors.forename: David J
authors.initials: DJ
authors.lastname: Vaughn
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002675:Child, Preschool; D006801:Humans; D010879:Piperazines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D013724:Teratoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; D011725:Pyridines; C500026:palbociclib
keywords: brain tumor; cyclin-dependent kinase; germ cell tumor; teratoma