title: Synthesis of18F-labeled phenolphthalein and naphtholphthalein.
abstract: The fluorination of phenolphthalein and naphtholphthalein was performed with diluted fluorine gas under acidic conditions. For both compounds we observed an electrophilic fluorination into ortho position to the hydroxyl group. Through the use of this reaction we synthesized and characterized mono-and difluorinated derivatives of phenolphthalein and naphtholphthalein. The compounds were also prepared in the18F labeled form, which are usable as a new type of probe forin vivopH measurement in biological objects using Cerenkov imaging or combination of light absorption and PET.
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kachur
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Popov
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: E James
authors.initials: EJ
authors.lastname: Delikatny
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Joel S
authors.initials: JS
authors.lastname: Karp
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Anatoliy V
authors.initials: AV
authors.lastname: Popov
keywords: Electrophilic fluorination; F-18; Naphtholphthalein; Phenolphthalein