title: Comparison of the efficacy of methotrexate and actinomycin D in the treatment of patients with stage I low risk gestational trophoblastic neoplasia (GTN).
abstract: BACKGROUND
  Gestational trophoblastic neoplasia (GTN) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. Even in its metastatic forms GTN is curable with a cure rate of 90-100 %. Currently, methotrexate with or without folic acid, andactinomycin D is recommended for low risk GTN. The aim of this study is to compare the efficacy of methotrexate and actinomycin D as the first-line single chemotherapeutic agents for women with low-risk gestational trophoblastic neoplasia (LR-GTN).
  
  
  METHODS
  A total of 30 women with LR-GTN were randomized to receive a weekly pulsed dose of 40 mg/m (2) of methotrexate intramuscularly (n=15) or a pulsed intravenous bolus of 1.25 mg/m (2) of actinomycin D every 2 weeks (n=15). An additional cycle was administered as consolidation treatment following normalization of the serum level of beta-human chorionic gonadotropin (˂10 IU/L).
  
  
  RESULTS
  Complete remission was achieved in 53.3% of patients in the methotrexate group and 86.7% in the actinomycin D group (p˂0.04). The mean number of treatment cycles needed to achieve response was lower in the actinomycin D group (4.3 vs. 6.5). The mean duration from beginning of treatment till achieving complete remission was 9.6 weeks for the Act group and 13 weeks for the MTX group.
  
  
  CONCLUSIONS
  Actinomycin D may be a better option than methotrexate as a first-line chemotherapy agent for patients with LR-GTN but larger multicenter randomized controlled trials should be conducted to establish the most appropriate regimen for these patients.
authors.affiliation: 1. Associate Professor of Gynecology, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. Shahbazian449@yahoo.com.
authors.forename: Nahid
authors.initials: N
authors.lastname: Shahbazian
authors.affiliation: 2. Associate Professor of Gynecology, Gynecologist, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. Dr.taghirazi@gmail.com.
authors.forename: Taghi
authors.initials: T
authors.lastname: Razi
authors.affiliation: 3. Gynecologist, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. Landscapes78@yahoo.com.
authors.forename: Shima
authors.initials: S
authors.lastname: Razi
authors.affiliation: 1. Associate Professor of Gynecology, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. Shahbazian449@yahoo.com.
authors.forename: Leila
authors.initials: L
authors.lastname: Yazdanpanah
keywords: Actinomycin D; Gestational Trophoblastic Disease (GTD); Methotrexate