title: The BioGRID interaction database: 2015 update.
abstract: The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species and humans. As of September 2014, the BioGRID contains 749,912 interactions as drawn from 43,149 publications that represent 30 model organisms. This interaction count represents a 50% increase compared to our previous 2013 BioGRID update. BioGRID data are freely distributed through partner model organism databases and meta-databases and are directly downloadable in a variety of formats. In addition to general curation of the published literature for the major model species, BioGRID undertakes themed curation projects in areas of particular relevance for biomedical sciences, such as the ubiquitin-proteasome system and various human disease-associated interaction networks. BioGRID curation is coordinated through an Interaction Management System (IMS) that facilitates the compilation interaction records through structured evidence codes, phenotype ontologies, and gene annotation. The BioGRID architecture has been improved in order to support a broader range of interaction and post-translational modification types, to allow the representation of more complex multi-gene/protein interactions, to account for cellular phenotypes through structured ontologies, to expedite curation through semi-automated text-mining approaches, and to enhance curation quality control.
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Chatr-Aryamontri
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Sven
authors.initials: S
authors.lastname: Heinicke
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
authors.forename: Daici
authors.initials: D
authors.lastname: Chen
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Nadine
authors.initials: N
authors.lastname: Kolas
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Lara
authors.initials: L
authors.lastname: O'Donnell
authors.affiliation: The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Nixon
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ramage
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Winter
authors.affiliation: Centre Hospitalier de l'Université Laval (CHUL), Québec, Québec G1V 4G2, Canada.
authors.forename: Adnane
authors.initials: A
authors.lastname: Sellam
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Christie
authors.initials: C
authors.lastname: Chang
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Jodi
authors.initials: J
authors.lastname: Hirschman
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Chandra
authors.initials: C
authors.lastname: Theesfeld
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rust
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Livstone
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK md.tyers@umontreal.ca.
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D025941:Protein Interaction Mapping
chemical_list: D016718:Arachidonic Acid