title: Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites.
abstract: Malaria-specific immune responses are altered in HIV/malaria-coinfected individuals and are associated with higher parasite burdens and more severe clinical disease. Monocyte/macrophage phagocytosis is a major mechanism of malaria parasite clearance. We hypothesized that phagocytosis of malaria-parasitized erythrocytes is impaired in coinfected individuals and could contribute to the increased parasite burdens observed. We show that nonopsonic phagocytosis of Plasmodium falciparum parasitized erythrocytes is impaired in monocytes isolated from HIV-infected individuals. The observed defects in phagocytic capacity were rescued after 6 months of antiretroviral therapy, demonstrating the importance of HIV treatment and immune reconstitution in the context of coinfection.
authors.affiliation: *Sandra Rotman Centre for Global Health, UHN, Toronto, Ontario, Canada; †Toronto General Research Institute, UHN, Toronto, Ontario, Canada; ‡Maple Leaf Research and Women's College Research Institute, Toronto, Ontario, Canada; and §Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Lena
authors.initials: L
authors.lastname: Serghides
authors.forename: Constance A M
authors.initials: CA
authors.lastname: Finney
authors.forename: Kodjo
authors.initials: K
authors.lastname: Ayi
authors.forename: Mona
authors.initials: M
authors.lastname: Loutfy
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Kain
mesh_terms: D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002478:Cells, Cultured; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000276:immunology*; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents