title: Impact and Epidemiological Investigations into the Incursion and Spread of Peste des Petits Ruminants in the Comoros Archipelago: An Increased Threat to Surrounding Islands.
abstract: Late October 2012, a great number of deaths of unknown origin occurred in goat herds in the suburbs of Ngazidja, located in the Comoros archipelago. Few weeks later, laboratory testing requested by the animal health authorities resulted in the identification of peste des petits ruminants (PPR) infection. Notably, the Index case could be attributed to a sick goat imported from Tanzania. Viral isolation was successful from the lungs leading to the whole N nucleoprotein gene sequencing. Phylogenetic analysis revealed that the strain belongs to the lineage III which includes strains of eastern African origin. In addition, to evaluate the impact of PPR on the Comorian indigenous domesticated ruminant population, a cross-sectional PPR serological survey was conducted between April and July 2013. A low overall PPRV antibody prevalence 2.24% (95% CI [1.38; 3.08]) was detected with a Grande Comore prevalence of 3.34% (IC = [2.09; 4.63]) with a limited spread of the disease mainly due to farm practices such as limited contacts between farm animals and rapid slaughtering of sick animals.
authors.affiliation: UMR CMAEE, CIRAD, Sainte Clotilde, La Réunion, France.|UMR 1309 CMAEE, INRA, Montpellier, France.|Plateforme de recherche CYROI, Centre de Recherche et de Veille sur les maladies émergentes dans l'Océan Indien (CRVOI), Sainte Clotilde, La Réunion, France.
authors.forename: C
authors.initials: C
authors.lastname: Cêtre-Sossah
authors.affiliation: UMR 1309 CMAEE, INRA, Montpellier, France.|UMR CMAEE, CIRAD, Montpellier, France.
authors.forename: O
authors.initials: O
authors.lastname: Kwiatek
authors.affiliation: Vice-President, Ministry of Agriculture, Fisheries, Environment, Industry, Energy and Handicraft, Moroni, Republic of Comoros.
authors.forename: A
authors.initials: A
authors.lastname: Faharoudine
authors.affiliation: Vice-President, Ministry of Agriculture, Fisheries, Environment, Industry, Energy and Handicraft, Moroni, Republic of Comoros.
authors.forename: M
authors.initials: M
authors.lastname: Soulé
authors.affiliation: Vice-President, Ministry of Agriculture, Fisheries, Environment, Industry, Energy and Handicraft, Moroni, Republic of Comoros.
authors.forename: Y O
authors.initials: YO
authors.lastname: Moutroifi
authors.affiliation: UMR CMAEE, CIRAD, Sainte Clotilde, La Réunion, France.|UMR 1309 CMAEE, INRA, Montpellier, France.|Plateforme de recherche CYROI, Centre de Recherche et de Veille sur les maladies émergentes dans l'Océan Indien (CRVOI), Sainte Clotilde, La Réunion, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Vrel
authors.affiliation: UMR 1309 CMAEE, INRA, Montpellier, France.|UMR CMAEE, CIRAD, Montpellier, France.
authors.forename: H
authors.initials: H
authors.lastname: Salami
authors.affiliation: Institut National de la recherche agricole, la pêche et l'environnement, Vice-présidence en charge de la Production, Moroni, Republic of Comoros.
authors.forename: S
authors.initials: S
authors.lastname: Rassoul
authors.affiliation: Institut National de la recherche agricole, la pêche et l'environnement, Vice-présidence en charge de la Production, Moroni, Republic of Comoros.
authors.forename: M
authors.initials: M
authors.lastname: Asnaoui
authors.affiliation: Vice-President, Ministry of Agriculture, Fisheries, Environment, Industry, Energy and Handicraft, Moroni, Republic of Comoros.
authors.forename: Y
authors.initials: Y
authors.lastname: Moindjie
authors.affiliation: UMR 1309 CMAEE, INRA, Montpellier, France.|UMR CMAEE, CIRAD, Petit Bourg, Guadeloupe, France.
authors.forename: E
authors.initials: E
authors.lastname: Albina
authors.affiliation: UMR 1309 CMAEE, INRA, Montpellier, France.|UMR CMAEE, CIRAD, Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Libeau
authors.affiliation: UMR CMAEE, CIRAD, Sainte Clotilde, La Réunion, France.|UMR 1309 CMAEE, INRA, Montpellier, France.|Plateforme de recherche CYROI, Centre de Recherche et de Veille sur les maladies émergentes dans l'Océan Indien (CRVOI), Sainte Clotilde, La Réunion, France.
authors.forename: E
authors.initials: E
authors.lastname: Cardinale
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D017507:Comoros / Q000453:epidemiology; D003430:Cross-Sectional Studies; D008168:Lung / Q000821:virology; D029021:Peste-des-Petits-Ruminants / Q000453:epidemiology*; D018107:Peste-des-petits-ruminants virus / Q000235:genetics / Q000276:immunology; D010802:Phylogeny
chemical_list: D000914:Antibodies, Viral
keywords: Comoros archipelago; emerging diseases; epidemiology; peste des petits ruminants; viral infections