title: Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.
abstract: The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into the brain and its subsequent metabolism. We review the methods used to study cerebral glucose metabolism with a focus on those used in clinical TBI studies. Arterio-venous measurements provide a global measure of glucose uptake into the brain. Microdialysis allows the in vivo sampling of brain extracellular fluid and is well suited to the longitudinal assessment of metabolism after TBI in the clinical setting. A recent novel development is the use of microdialysis to deliver glucose and other energy substrates labelled with carbon-13, which allows the metabolism of glucose and other substrates to be tracked. Positron emission tomography and magnetic resonance spectroscopy allow regional differences in metabolism to be assessed. We summarise the data published from these techniques and review their potential uses in the clinical setting.
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167 Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK, ij232@cam.ac.uk.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Jalloh
authors.forename: Keri L H
authors.initials: KL
authors.lastname: Carpenter
authors.forename: Adel
authors.initials: A
authors.lastname: Helmy
authors.forename: T Adrian
authors.initials: TA
authors.lastname: Carpenter
authors.forename: David K
authors.initials: DK
authors.lastname: Menon
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hutchinson
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods; D001930:Brain Injuries / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology; D045604:Extracellular Fluid / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D017551:Microdialysis / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D005947:Glucose