title: Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.
abstract: The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affected more parameters: it reduced exploratory activity 1 h after administration and stimulated exploratory and motor activity in 2 h. In female mice, J447H significantly reduced the number of peepings into holes in 2 h after administration. The results indicate that further analysis of the effects of J579 and especially J447H is required.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia, avgust@bionet.nsc.ru.
authors.forename: D F
authors.initials: DF
authors.lastname: Avgustinovich
authors.forename: M K
authors.initials: MK
authors.lastname: Fomina
authors.forename: E V
authors.initials: EV
authors.lastname: Suslov
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: K P
authors.initials: KP
authors.lastname: Volcho
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
mesh_terms: D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003624:Darkness; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D012737:Sex Factors
chemical_list: C070094:2-aminoadamantane; D000547:Amantadine