title: [The effect of destruction of rat capsaicin-sensitive nerves on blood pressure in rats with metabolic syndrome].
abstract: The effect of destruction of capsaicin-sensitive nerve (capsaicin 150 mg/kg, s/c) on blood pre- ssure was investigated in rats with metabolic syndrome induced by fructose (12.5% in drinking water for 10 weeks). The blood plasma concentrations of glucose, triglyceride (TG) and products of lipid perioxidation were defined in these rats. The systolic blood pressure was measured by non-invasive method using the Coda system (Coda, Kent Scientific, USA). The fructose diet caused impaired tolerance glucose, arterial hypertension, increased the contents of TG and products of lipid peroxidation. In capsaicin--pretreated rats (deafferentiation of capsaicin-sensitive nerve) the fructose intake did not evoke impairment tolerance glucose, the increase of systolic blood pressure and the plasma content of triglyceride. The increase of lipid perioxidation in fructose fed rats was not prevented by capsaicin pretreatment. The authors suggest that capsaicin-sensitive nerves contribute to the development of insulin resistance and arterial hypertension in the metabolic syndrome.
authors.forename: V K
authors.initials: VK
authors.lastname: Spiridonov
authors.forename: Z S
authors.initials: ZS
authors.lastname: Tolochko
authors.forename: N E
authors.initials: NE
authors.lastname: Kostina
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000378:metabolism*; D005632:Fructose / Q000633:toxicity; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats
chemical_list: D001786:Blood Glucose; D005632:Fructose; D002211:Capsaicin