title: Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): a potential source for functional food ingredients and drug formulations.
abstract: This study was focused on the analysis of the phenolic content, antioxidant, antibacterial, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase activity of three solvent extracts from Cotoneaster nummularia. Moreover, water extract was tested in terms of mutagenic/anti-mutagenic effects. The antioxidant activities of these extracts were evaluated by DPPH, ABTS, O2, metal chelating, phosphomolybdenum, β-carotene/linoleic acid, ferric and cupric reducing power assays. Enzyme inhibitory activities were also examined with colorimetric methods. Generally, methanol and water extracts exhibited excellent biological activities. These extracts were rich in phenolic and flavonoid content. Furthermore, Cotoneaster extracts indicated appreciable antibacterial properties against human pathogen strains. HPLC analysis showed that ferulic acid, chlorogenic acid, (-) - epicatechin and (+)-catechin were the major phenolics in extracts tested. These data offer that these extracts from C. nummularia may be considered as a potential source of biological agents for developing functional foods or drug formulations.
authors.affiliation: Selcuk University, Science Faculty, Department of Biology, Konya, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Zengin
authors.affiliation: Selcuk University, Vocational School of Health Services, Konya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uysal
authors.affiliation: Selcuk University, Science Faculty, Department of Biology, Konya, Turkey.
authors.forename: Erdogan
authors.initials: E
authors.lastname: Gunes
authors.affiliation: Selcuk University, Science Faculty, Department of Biology, Konya, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Aktumsek
mesh_terms: D000085:Acetates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D055951:Functional Food; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D027824:Rosaceae / Q000737:chemistry* / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D004798:Enzymes; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D014867:Water; C007650:ethyl acetate; D000432:Methanol