title: A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells.
abstract: A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death.
authors.affiliation: Department of Immunology, Faculty of Medicine, Kinki University, 377-2 Ohno-Higashi, Sayama, Osaka 589-8511, Japan. hakata@med.kindai.ac.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Hakata
authors.forename: S
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Michiue
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Miyazawa
authors.forename: M
authors.initials: M
authors.lastname: Kitamatsu
mesh_terms: D000595:Amino Acid Sequence; D001343:Autophagy / Q000187:drug effects*; D057846:Cell-Penetrating Peptides / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D016350:Leucine Zippers; D008969:Molecular Sequence Data; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D057846:Cell-Penetrating Peptides; D010455:Peptides