title: Risk factors for biliary complications after orthotopic liver transplantation with T-tube: a single-center cohort of 743 transplants.
abstract: BACKGROUND
  Despite recent advances in organ preservation, surgical procedures, and immunosuppression, biliary reconstruction after orthotopic liver transplantation (OLT) remains as a major source of morbidity. The purpose of this study was to identify risk factors for the development of biliary complications (BCs) after end-to-end choledochocholedochostomy (EE-CC) with a T-tube as the standard technique for biliary reconstruction after OLT.
  
  
  METHODS
  A total of 833 consecutive liver transplantations that took place from February 1996 to April 2010 were retrospectively reviewed. Patients with concomitant hepatic artery complications were excluded, as were those who underwent urgent retransplantation or died within 1 week after transplantation. Finally, the study group comprised 743 patients.
  
  
  RESULTS
  The overall BC rate was 9.8% (73 patients), including stricture in 19 patients (2.6%) and bile leakage in 39 patients (5.2%). After univariate analysis, significant risk factors for BCs were surgery time >5 hours, arterial ischemia time >30 minutes, use of a classic transplant technique, transfusion of red blood cells ≥5 units, anti-cytomegalovirus treatment, and period of transplantation between 1996 and 2002. Stepwise logistic regression study was performed, including those variables with a value of P <.200. Multivariate analysis showed that pretransplant serum creatinine (odds ratio = 1.27; 95% confidence interval [CI], 1.03-1.57; P = .025) and arterial ischemia time >30 minutes (odds ratio = 2.44; 95% CI, 1.45-4.12; P = .001) were the only independent risk factors related to the development of BCs after biliary reconstruction with the T-tube.
  
  
  CONCLUSIONS
  The performance of different variables in predicting occurrence of BCs was assessed with the use of receiver operating characteristic analysis. The area under the receiver operating characteristic curve of our model was 0.637 (95% CI, 0.564-0.710), and therefore we must conclude that other variables not included in our model may have influence in the development of BCs after OLT with an EE-CC with a T-tube as the procedure for biliary reconstruction.
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain. Electronic address: mikelgastaca@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Gastaca
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Matarranz
authors.affiliation: Hepatology Unit, Cruces University Hospital, Bilbao, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Martinez
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Valdivieso
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, Bilbao, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ventoso
authors.affiliation: Hepatology Unit, Cruces University Hospital, Bilbao, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Fernandez
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Palomares
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Prieto
authors.affiliation: Hepatology Unit, Cruces University Hospital, Bilbao, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Suarez
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ortiz de Urbina
mesh_terms: D001660:Biliary Tract Diseases / Q000453:epidemiology / Q000209:etiology*; D002768:Choledochostomy / Q000009:adverse effects* / Q000295:instrumentation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology