title: A new metabolite panel test for identification of patients with impaired glucose tolerance? Analysis of the article by Cobb et al.
abstract: The article by Cobb et al represents solid research work applying the most sophisticated laboratory technologies, a very sound clinical research methodology, and valid statistical analysis procedures. The authors have identified a combination of metabolites suitable to replace the oral glucose tolerance test procedure in the identification of patients with impaired glucose tolerance (IGT) from a fasting blood draw. However, the discussed pathophysiological, clinical, and economic aspects may induce mechanisms restricting the probability of a global acceptance of this test for daily routine.
authors.affiliation: Pfützner Science & Health Institute, Mainz, Germany andreas.pfuetzner@pfuetzner-mainz.com.
authors.forename: Andreas
authors.initials: A
authors.lastname: Pfützner
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008297:Male
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: IQ-IGT metabolite panel; impaired glucose tolerance; metabolomics; oral glucose tolerance test