title: Zebrafish brain mapping--standardized spaces, length scales, and the power of N and n.
abstract: Mapping anatomical and functional parameters of the zebrafish brain is moving apace. Research communities undertaking such studies are becoming ever larger and more diverse. The unique features, tools, and technologies associated with zebrafish are propelling them as the 21st century model organism for brain mapping. Uniquely positioned as a vertebrate model system, the zebrafish enables imaging of anatomy and function at different length scales from intraneuronal compartments to sparsely distributed whole brain patterns. With a variety of diverse and established statistical modeling and analytic methods available from the wider brain mapping communities, the richness of zebrafish neuroimaging data is being realized. The statistical power of population observations (N) within and across many samples (n) projected onto a standardized space will provide vast databases for data-driven biological approaches. This article reviews key brain mapping initiatives at different levels of scale that highlight the potential of zebrafish brain mapping. By way of introduction to the next wave of brain mappers, an accessible introduction to the key concepts and caveats associated with neuroimaging are outlined and discussed.
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, Guy's Hospital Campus, London, SE1 1UL, United Kingdom.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hunter
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, Guy's Hospital Campus, London, SE1 1UL, United Kingdom.
authors.forename: Aenea C
authors.initials: AC
authors.lastname: Hendry
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, Guy's Hospital Campus, London, SE1 1UL, United Kingdom.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Lowe
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000639:trends; D015870:Gene Expression; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D059906:Neuroimaging; D015027:Zebrafish / Q000033:anatomy & histology* / Q000254:growth & development
chemical_list: D008164:Luminescent Proteins
keywords: brain mapping; function; neuroimaging; standardized space; zebrafish