title: Effects of polyunsaturated fatty acids on periprocedural myocardial infarction after elective percutaneous coronary intervention.
abstract: OBJECTIVE
  The aim of this study was to address the association of lipid profiles with periprocedural myocardial infarction (pMI) after elective percutaneous coronary intervention (PCI).
  
  
  RESULTS
  Of the 302 consecutive patients who received elective PCI at the Chubu Rosai Hospital, Nagoya, Japan between June 2009 and December 2010, data from 231 native coronary lesions were analysed. Various biomarkers including serum troponin T (TnT), eicosapentaenoic acid (EPA), arachidonic acid (AA), and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol were measured at baseline and at 18 hrs after PCI. pMI was defined as a post-procedural increase of TnT >3 times above the upper normal limit. Patients with pMI had significantly lower EPA/AA (0.25 [0.19-0.28] vs. 0.45 [0.21-0.62], p<0.001) and higher LDL/HDL cholesterol (3.00±1.05 vs. 2.36±0.90, p=0.008) than patients without pMI. On multivariate logistic analysis, EPA/AA per 0.1 increase (hazard ratio [HR] 0.62, 95% CI: 0.43-0.88, p=0.007), LDL/HDL (HR 1.92, 95% CI: 1.15-3.19, p=0.012), stented length (HR 1.40, 95% CI: 1.07-1.83, p=0.015), and the presence of unstable angina pectoris (UAP) (HR 8.89, 95% CI: 2.83-27.9, p<0.001) were significantly and independently associated with the incidence of pMI.
  
  
  CONCLUSIONS
  EPA/AA and LDL/HDL were significantly associated with pMI after PCI, creating the possibility of a new therapeutic target of pMI.
authors.affiliation: Department of Cardiology, Aichi Medical University, Nagakute, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Suzuki
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Ando
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takashima
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kumagai
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kurita
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Waseda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Mizuno
authors.forename: Ken
authors.initials: K
authors.lastname: Harada
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Uetani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Daiji
authors.initials: D
authors.lastname: Yoshikawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D020107:Troponin T / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020107:Troponin T; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid