title: Dual-radiolabeled nanoparticle SPECT probes for bioimaging.
abstract: A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.
authors.affiliation: Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
authors.forename: Kvar C L
authors.initials: KC
authors.lastname: Black
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Akers
authors.forename: Gail
authors.initials: G
authors.lastname: Sudlow
authors.forename: Baogang
authors.initials: B
authors.lastname: Xu
authors.forename: Richard
authors.initials: R
authors.lastname: Laforest
authors.forename: Samuel
authors.initials: S
authors.lastname: Achilefu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D006046:Gold / Q000737:chemistry; D006801:Humans; D007205:Indium Radioisotopes / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014183:Transplantation, Heterologous
chemical_list: D003287:Contrast Media; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D006046:Gold; D020780:Matrix Metalloproteinase 9