title: Traditional cardiovascular risk factors and coronary artery calcification in adults with polymyositis and dermatomyositis: a Danish multicenter study.
abstract: OBJECTIVE
  To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score.
  
  
  METHODS
  Traditional CV risk factors were assessed in a cross-sectional, observational study of 76 patients with PM/DM and in 48 sex- and age-matched healthy controls. CAC was quantified by means of cardiac computed tomography scan and expressed in Agatston units. The associations between CV risk factors, PM/DM, and CAC were studied by multivariate analyses.
  
  
  RESULTS
  Thirty-three percent of the patients were obese compared to 11% of the controls (P = 0.005). Hypertension and diabetes mellitus were more frequent in patients (71% versus 42%; P = 0.002, and 13% versus 0%; P = 0.007), and patients had higher levels of triglycerides (P = 0.0009). High CAC score occurred more frequently in patients (20% versus 4%; P = 0.04). In multivariate analysis of patient factors associated with CAC were age (P = 0.02) and smoking (P = 0.02).
  
  
  CONCLUSIONS
  In this study, traditional CV risk factors and severe CAC were commonly found in patients with PM/DM. However, severe CAC was not associated with PM/DM per se, but rather with age and smoking in these patients.
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Louise P
authors.initials: LP
authors.lastname: Diederichsen
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Axel C P
authors.initials: AC
authors.lastname: Diederichsen
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Simonsen
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Junker
authors.affiliation: Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Klaus
authors.initials: K
authors.lastname: Søndergaard
authors.affiliation: Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Ingrid E
authors.initials: IE
authors.lastname: Lundberg
authors.affiliation: Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Tvede
authors.affiliation: Odense University Hospital, and University of Southern Denmark, Odense, Denmark.
authors.forename: Oke
authors.initials: O
authors.lastname: Gerke
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Christensen
authors.affiliation: Gentofte University Hospital, Hellerup, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Dreyer
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Petersen
authors.affiliation: Esbjerg Hospital, Esbjerg, Denmark.
authors.forename: Leif
authors.initials: L
authors.lastname: Ejstrup
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Susan D
authors.initials: SD
authors.lastname: Kay
authors.affiliation: Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Jacobsen
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D003882:Dermatomyositis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D017285:Polymyositis / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000453:epidemiology*