title: Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines.
abstract: A series of cyclic 2,6-bis-(1,2,3-triazolyl)-pyridine anion receptors with thiourea functionalities were synthesized by click reaction of 2,6-diazidopyridine with protected propargylamine followed by condensation of a bisthiocyanate derivative with a series of diamines. Their chloride binding affinities as well as their transport properties in POPC bilayers were examined. These receptors were found to function as anion carriers, which can mediate both Cl(-)/NO3(-) antiport and H(+)/Cl(-) symport, and the transport activity of these hosts were dominated by their lipophilicity.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Tamara
authors.initials: T
authors.lastname: Merckx
authors.forename: Cally J E
authors.initials: CJ
authors.lastname: Haynes
authors.forename: Louise E
authors.initials: LE
authors.lastname: Karagiannidis
authors.forename: Harriet J
authors.initials: HJ
authors.lastname: Clarke
authors.forename: Katie
authors.initials: K
authors.lastname: Holder
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kelly
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Tizzard
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Coles
authors.forename: Peter
authors.initials: P
authors.lastname: Verwilst
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gale
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen