title: Blau syndrome: cross-sectional data from a multicentre study of clinical, radiological and functional outcomes.
abstract: OBJECTIVE
  To report baseline articular, functional and ocular findings of the first international prospective cohort study of Blau syndrome (BS).
  
  
  METHODS
  Three-year, multicentre, observational study on articular, functional (HAQ, Childhood HAQ and VAS global and pain), ophthalmological, therapeutic and radiological data in BS patients.
  
  
  RESULTS
  Baseline data on the first 31 recruited patients (12 females and 19 males) from 18 centres in 11 countries are presented. Of the 31 patients, 11 carried the p.R334W NOD2 mutation, 9 the p.R334Q and 11 various other NOD2 missense mutations; 20 patients were sporadic and 11 from five BS pedigrees. Median disease duration was 12.8 years (1.1-57). Arthritis, documented in all but one patient, was oligoarticular in 7, polyarticular in 23. The median active joint count was 21. Functional capacity was normal in 41%, mildly impaired in 31% and moderate-severe in 28% of patients. The most frequently involved joints at presentation were wrists, ankles, knees and PIPs. On radiographs, a symmetrical non-erosive arthropathy was shown. Previously unknown dysplastic bony changes were found in two-thirds of patients. Ocular disease was documented in 25 of 31 patients, with vitreous inflammation in 64% and moderate-severe visual loss in 33%. Expanded manifestations (visceral, vascular) beyond the classic clinical triad were seen in 52%.
  
  
  CONCLUSIONS
  BS is associated with severe ocular and articular morbidity. Visceral involvement is common and may be life-threatening. Bone dysplastic changes may show diagnostic value and suggest a previously unknown role of NOD2 in bone morphogenesis. BS is resistant to current drugs, suggesting the need for novel targeted therapies.
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Rosé
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Pans
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Ingele
authors.initials: I
authors.lastname: Casteels
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Jordi
authors.initials: J
authors.lastname: Anton
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bader-Meunier
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Brissaud
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Roland
authors.initials: R
authors.lastname: Cimaz
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Graciella
authors.initials: G
authors.lastname: Espada
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernandez-Martin
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Eric
authors.initials: E
authors.lastname: Hachulla
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Harjacek
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Raju
authors.initials: R
authors.lastname: Khubchandani
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Friederike
authors.initials: F
authors.lastname: Mackensen
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Rosa
authors.initials: R
authors.lastname: Merino
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Antonio
authors.initials: A
authors.lastname: Naranjo
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Sheila
authors.initials: S
authors.lastname: Oliveira-Knupp
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Pajot
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Russo
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Thomée
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Vastert
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Nico
authors.initials: N
authors.lastname: Wulffraat
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Juan I
authors.initials: JI
authors.lastname: Arostegui
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Foley
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
authors.forename: John
authors.initials: J
authors.lastname: Bertin
authors.affiliation: Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, Department of Radiology, Department of Ophthalmology, Catholic University of Leuven (KU Leuven), Leuven, Belgium, Unidad de Reumatologia Pediatrica, Universidad de Barcelona, Barcelona, Spain, Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Hospital Necker-Enfants Malades, Inserm U 768, Imagine Foundation, Paris, Rheumatology Practice, Neuilly-sur-Seine, France, Dipartimento di Pediatria, Universita degli Studi di Firenze, Firenze, Italy, Seccion Reumatologia, Universidad de Buenos Aires, Buenos Aires, Argentina, Fundación Biomédica Galicia Sur Hospital Meixoeiro, Hospital do Meixoeiro, Vigo, Spain, Service de Médecine Interne, Hôpital Claude Huriez, Lille, France, Department of Rheumatology, University of Zagreb, Zagreb, Croatia, Department of Paediatrics, Jaslok Hospital, Mumbai, India, Interdisciplinary Uveitis Center, Universitat Klinikum Heidelberg, Heidelberg, Germany, Unidad de Reumatologia Pediatrica, Hospital La Paz, Madrid, Servicio de Rheumatologia, Hospital de Gran Canarias Dr Negrin, Las Palmas, Spain, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidad Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Pédiatrie - Néphrologie, Médecine Interne et Hypertension, Hôpital des Enfants, Toulouse, France, Servicio de Immunologia/Reumatologia, University of Buenos Aires, Buenos Aires, Argentina, Pediatric Clinic, Centre Hospitalier de Luxemburg, Luxembourg, Luxembourg, Division of Pediatrics, Department of Pediatric Immunology and Rheumatology, UMC Utrecht, Utrecht, The Netherlands, Department of Immunology-CDB, Hospital Clinic Barcelona, Spain, Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania, USA and Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium carine.wouters@uzleuven.be.
authors.forename: Carine H
authors.initials: CH
authors.lastname: Wouters
mesh_terms: D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003389:Cranial Nerve Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011446:Prospective Studies; D011859:Radiography; D012507:Sarcoidosis; D012871:Skin Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D013585:Synovitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D016896:Treatment Outcome; D014605:Uveitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D055815:Young Adult; D056660:Hereditary Autoinflammatory Diseases
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Blau syndrome; NOD2; sarcoidosis; uveitis