title: Comparing the use of protons and carbon ions for treatment.
abstract: Protons and carbon ions currently are the most used charged-particle therapies in the cancer treatment of humans. This review summarizes the physical and biological differences and their impact on clinical use. Furthermore, published data in the treatment of several tumor entities and the use of protons and carbon ions are collected and discussed.
authors.affiliation: From the *Department of Radiation Oncology, University of Heidelberg; †Heidelberg Ion Beam Therapy Center (HIT); ‡German Cancer Research Center (DKFZ); §Heidelberg Institute of Radiation Oncology (HIRO); and ∥Deutsches Konsortium für Translationale Krebsforschung (DKTK), Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Uhl
authors.forename: Klaus
authors.initials: K
authors.lastname: Herfarth
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy; D002813:Chondrosarcoma / Q000532:radiotherapy; D002817:Chordoma / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D063193:Heavy Ion Radiotherapy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D061766:Proton Therapy / Q000295:instrumentation / Q000379:methods*; D011829:Radiation Dosage; D019292:Skull Base Neoplasms / Q000532:radiotherapy