title: Effects of aqueous extracts of Acacia albida stem bark on Wistar albino rats infected with Trypanosoma evansi.
abstract: The effect of aqueous extract of Acacia albida stem bark was investigated in Wistar albino rats infected with Trypanosoma evansi. The extract showed highest reduction in parasitemia at the dose of 600 mg/kg body weight (bw). A dose of 300 mg/kg bw improved packed cell volume the most by 14.35%. The group treated with 150 and 600 mg/kg bw of the extract showed significant decrease (P < 0.05) in alanine transaminase and aspartate transaminase levels which were lower than those of the group treated with diminazene aceturate. The group treated with 150 mg/kg bw of the extract showed the least urea, albumin and protein level and lowest relative organ weight. There was a significant difference (P < 0.05) in the levels of catalase and Thiobarbituric acid reactive substances in liver and kidney of the animals in the infected-untreated group and the extracts-treated groups. The results of this study show that the extracts of A. albida have antitrypanosomal activity against T. evansi infection.
authors.affiliation: a Department of Biochemistry, Ahmadu Bello University , Zaria , Nigeria.
authors.forename: Uche Samuel
authors.initials: US
authors.lastname: Ndidi
authors.forename: Ismaila Alhaji
authors.initials: IA
authors.lastname: Umar
authors.forename: Aminu
authors.initials: A
authors.lastname: Mohammed
authors.forename: Cosmas
authors.initials: C
authors.lastname: Samuel
authors.forename: Amos Oladiran
authors.initials: AO
authors.lastname: Oladeru
authors.forename: Rahinat Nimma
authors.initials: RN
authors.lastname: Yakubu
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004133:Diminazene / Q000031:analogs & derivatives / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D018512:Parasitemia / Q000188:drug therapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014344:Trypanocidal Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C003915:diminazene aceturate; D004133:Diminazene
keywords: Acacia albida; Trypanosoma evansi; aqueous extract; parasitemia; stem bark