title: Estimating HIV incidence from case-report data: method and an application in Colombia.
abstract: OBJECTIVE
  Quantifying HIV incidence is essential for tracking epidemics but doing this in concentrated epidemic can be a particular challenge because of limited consistent high-quality data about the size, behaviour and prevalence of HIV among key populations. Here, we examine a method for estimating HIV incidence from routinely collected case-reporting data.
  
  
  METHODS
  A flexible model of HIV infection, diagnosis and survival is constructed and fit to time-series data on the number of reported cases in a Bayesian framework. The time trend in the hazard of infection is specified by a penalized B-spline. We examine the performance of the model by applying it to synthetic data and determining whether the method is capable of recovering the input incidence trend. We then apply the method to real data from Colombia and compare our estimates of incidence with those that have been derived using alternative methods.
  
  
  RESULTS
  The method can feasibly be applied and it successfully recovered a range of incidence trajectories in synthetic data experiments. However, estimates for incidence in the recent past are highly uncertain. When applied to data from Colombia, a credible trajectory of incidence is generated which indicates a much lower historic level of HIV incidence than has previously been estimated using other methods.
  
  
  CONCLUSIONS
  It is feasible, though not satisfactory, to estimate incidence using case-report data in settings with good data availability. Future work should examine the impact on missing or biased data, the utility of alternative formulations of flexible functions specifying incidence trends, and the benefit of also including data on deaths and programme indicators such as the numbers receiving antiretroviral therapy.
authors.affiliation: aDepartment of Infectious Disease Epidemiology, Imperial College London, London, UK bStichting HIV Monitoring, Amsterdam, the Netherlands.
authors.forename: Juan Fernando
authors.initials: JF
authors.lastname: Vesga
authors.forename: Anne
authors.initials: A
authors.lastname: Cori
authors.forename: Ard
authors.initials: A
authors.lastname: van Sighem
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Hallett
mesh_terms: D003105:Colombia / Q000453:epidemiology; D004812:Epidemiologic Methods; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008962:Models, Theoretical