title: The contributions of Sidney D. Nelson to drug metabolism research.
abstract: This article provides a review of Sid Nelson's key contributions to the fields of drug metabolism and toxicology over a long and distinguished career. Selected examples are discussed to illustrate the diversity of Sid's research, with an emphasis on understanding mechanistic aspects of metabolic activation processes and structure-toxicity relationships. These examples serve to illustrate the importance of emerging mass spectrometry and isotope labeling techniques in elucidating details of foreign compound metabolism at the molecular level, an area in which Sid pioneered most effectively.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, University of Washington , Seattle, WA , USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Baillie
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D059232:Laboratory Personnel; D014116:Toxicology / Q000379:methods*
keywords: Acetaminophen; bioactivation; drug metabolism; reactive metabolites; toxicology