title: A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups.
abstract: A new fluorescent probe installed with dual-reactive and dual-quenching groups was rationally designed for highly selective and sensitive sensing of biothiols. The sensitivity of the probe toward thiols was significantly improved by dual-quenching effects. Furthermore the selectivity of the probe was also greatly enhanced by installation of dual-reactive groups.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. hongysun@cityu.edu.hk.
authors.forename: Huatang
authors.initials: H
authors.lastname: Zhang
authors.forename: Changyu
authors.initials: C
authors.lastname: Zhang
authors.forename: Ruochuan
authors.initials: R
authors.lastname: Liu
authors.forename: Long
authors.initials: L
authors.lastname: Yi
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
mesh_terms: D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives / Q000737:chemistry; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; C045305:2,4-dinitrofluorobenzene sulfonic acid; D004139:Dinitrofluorobenzene