title: Vascular toxicity associated with chemotherapy and molecular targeted therapy: what should a radiologist know?
abstract: OBJECTIVE
  Venous and arterial thromboembolic events and rarely hemorrhage are complications of chemotherapy and, more recently, of molecular targeted therapy in patients with solid and hematologic malignancies. This article will use a drug-based approach to illustrate, with examples, vessel damage and end-organ damage induced by molecular targeted therapy and chemotherapy in cancer patients and will provide a clinical perspective.
  
  
  CONCLUSIONS
  Imaging plays a key role in the detection of complications of cancer therapies. A high index of suspicion and an awareness of modern-day drug toxicities are key to the early diagnosis and management of these complications.
authors.affiliation: 1 Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Rohatgi
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.forename: Michael H
authors.initials: MH
authors.lastname: Rosenthal
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004358:Drug Therapy / Q000379:methods; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D013923:Thromboembolism / Q000139:chemically induced* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents
keywords: chemotherapy; embolism; hemorrhage; molecular targeted therapy; thrombosis