title: Prevention of nephrotoxicity induced by cyclosporine-A: role of antioxidants.
abstract: Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA-induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity.
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", 80137, Naples, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Damiano
authors.forename: Roberto
authors.initials: R
authors.lastname: Ciarcia
authors.forename: Serena
authors.initials: S
authors.lastname: Montagnaro
authors.forename: Ugo
authors.initials: U
authors.lastname: Pagnini
authors.forename: Tiziana
authors.initials: T
authors.lastname: Garofano
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Capasso
authors.forename: Salvatore
authors.initials: S
authors.lastname: Florio
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D016572:Cyclosporine
keywords: ANTIOXIDANT; CYCLOSPORINE-A (CsA); NEPHROTOXICITY; REACTING OXYGEN SPECIES (ROS)