title: The Portuguese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) in the diagnosis of subcortical vascular dementia and Alzheimer's disease.
abstract: The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer's disease (AD). Ninety-two subjects (18 SVD patients, 36 AD patients, and 38 healthy controls) were assessed using the ACE-R. Between-group's differences were evaluated using the Quade's rank analysis of covariance. The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic (ROC) analysis. The ACE-R was able to successfully discriminate between patients and healthy subjects. The mean ACE-R total scores differed between SVD and AD patients; there were also significant differences in attention and orientation and in memory measures between the groups. An optimal cut-off of 72/73 was found for the detection of AD (sensitivity: 97%; specificity: 92%) and SVD (sensitivity: 100%; specificity: 92%).
authors.affiliation: a Faculty of Psychology and Educational Sciences , University of Coimbra , Coimbra , Portugal.
authors.forename: Cátia
authors.initials: C
authors.lastname: Gonçalves
authors.forename: Maria Salomé
authors.initials: MS
authors.lastname: Pinho
authors.forename: Vitor
authors.initials: V
authors.lastname: Cruz
authors.forename: Joana
authors.initials: J
authors.lastname: Pais
authors.forename: Helena
authors.initials: H
authors.lastname: Gens
authors.forename: Fátima
authors.initials: F
authors.lastname: Oliveira
authors.forename: Isabel
authors.initials: I
authors.lastname: Santana
authors.forename: José
authors.initials: J
authors.lastname: Rente
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Santos
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011174:Portugal; D012372:ROC Curve; D015203:Reproducibility of Results
keywords: Addenbrooke’s Cognitive Examination–Revised; Alzheimer’s disease; dementia; screening; subcortical vascular dementia