title: CIZ1 promoted the growth and migration of gallbladder cancer cells.
abstract: Gallbladder cancer (GBC) is one of the most common and aggressive diseases among the gastrointestinal tract malignancies, and the molecular mechanism underlying this disease remains largely unknown. CIZ1 (Cip1 interacting zinc finger protein 1), a binding partner of p21(Cip1/Waf1), has been found to be involved in the tumorigenesis recently. However, the expression pattern and biological functions of CIZ1 in the progression of GBC are not fully understood. In this study, it was found that the expression of CIZ1 was significantly elevated in GBC samples compared to their adjacent normal tissues. Moreover, overexpression of CIZ1 promoted the growth and migration of GBC cells, while knocking down the expression of CIZ1 inhibited the growth, migration, and tumorigenesis of GBC cells in vitro and in vivo. Mechanistically, CIZ1 was found to interact with TCF4 (T-cell factor) and activate beta-catenin/TCF signaling. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC.
authors.affiliation: General Surgery Department, Zhongshan Hospital, General Surgery Institute, Fudan University, 180 Fenglin Rd., 200032, Shanghai, China.
authors.forename: Dexiang
authors.initials: D
authors.lastname: Zhang
authors.forename: Yueqi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuedi
authors.initials: Y
authors.lastname: Dai
authors.forename: Jiwen
authors.initials: J
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Suo
authors.forename: Hongtao
authors.initials: H
authors.lastname: Pan
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Shen
authors.forename: Houbao
authors.initials: H
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction; D051176:beta Catenin / Q000235:genetics
chemical_list: C400423:Ciz1 protein, human; D009687:Nuclear Proteins; D051176:beta Catenin