title: A mini review on biological activities of pyridazinone derivatives as antiulcer, antisecretory, antihistamine and particularly against histamine H3R.
abstract: Pyridazinone derivatives and their related analoges were introduced for gastric antiulcer and antisecretory activities. Selected compounds were applied to ulcer models and showed their antiulcer and anti secretary activities. Some pyridazinone compounds are recently reported as H3R antagonists. Some amine analogs of pyridazinones, pyridazinone- phenethylamines and 4,5-fused pyridazinones showed histamine H3R antagonist activity with significant affinity for rat and human H3R. These pyridazinone analogs also showed excellent selectivity and metabolic stability, with adequate pharmacokinetics.
authors.affiliation: Department of Pharmacy, GRD (P.G) IMT, Dehradun, Uttarakhand, India.. aasif321@gmail.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asif
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D011724:Pyridazines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D014456:Ulcer / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D006633:Histamine Antagonists; D011724:Pyridazines; D018100:Receptors, Histamine H3; D006632:Histamine