title: Anti-leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from Tibouchina paratropica.
abstract: A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and compound 1 displayed potent anti-parasitic activity against Leishmania donovani (IC50  = 0.809 µg/mL). In addition, an 85% reduction in the secretion of the pro-inflammatory cytokine IL-6 was recorded when macrophages challenged with lipopolysaccharide were exposed to compound 1, but no effect on the anti-inflammatory IL-10 was observed. Compound 2 showed neither anti-parasitic nor anti-inflammatory properties. In addition, no cytotoxic activities were observed against the human-derived macrophage THP-1 cells.
authors.affiliation: Facultad de Agronomía y Zootecnia, Universidad Nacional de Tucumán, Av. Roca 1900, 4000, San Miguel de Tucumán, Argentina.
authors.forename: María I
authors.initials: MI
authors.lastname: Tracanna
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Fortuna
authors.forename: Angel V Contreras
authors.initials: AV
authors.lastname: Cárdenas
authors.forename: Alexandra K
authors.initials: AK
authors.lastname: Marr
authors.forename: W Robert
authors.initials: WR
authors.lastname: McMaster
authors.forename: Anaximandro
authors.initials: A
authors.lastname: Gómez-Velasco
authors.forename: Eugenio
authors.initials: E
authors.lastname: Sánchez-Arreola
authors.forename: Luis Ricardo
authors.initials: LR
authors.lastname: Hernández
authors.forename: Horacio
authors.initials: H
authors.lastname: Bach
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001118:Argentina; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D005658:Fungi / Q000187:drug effects; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D007893:Leishmania donovani / Q000187:drug effects*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D035322:Melastomataceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C000600990:2,8-dihydroxy-7H-furo(2,3-f)chromen-7-one; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000981:Antiprotozoal Agents; D011564:Furocoumarins; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; C016527:isoquercitrin; D016753:Interleukin-10; D011794:Quercetin
keywords: Melastomataceae; Tibouchina paratropica; bioactivities; phenolic derivatives