title: "Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values".
abstract: Balò's sclerosis is considered a rare variant of multiple sclerosis characterized by demyelination with concentric rings. Advanced magnetic resonance studies allow nowadays early diagnosis and prompt treatment. However, the pathophysiology of lesion evolution is still matter of debate, as detailed in our literature review. Based on a clear-cut Balò's lesion analysis, we describe early changes in DWI and ADC values within the different layers, favoring the concept of a centrifugal growth.
authors.affiliation: a Department of Neurology, University of Eastern Piedmont, Novara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ripellino
authors.affiliation: b APHP -Hôpital Pitié-Salpêtrière, Service de Chirurgie Maxillofaciale et Stomatologie, Paris, France; Sorbonne Universités, UPMC Univ Paris, Paris, France.
authors.forename: Roman
authors.initials: R
authors.lastname: Khonsari
authors.affiliation: c Department of Radiology, University of Eastern Piedmont, Novara, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Stecco
authors.affiliation: d Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University "Vita e Salute", OSR, Milan, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.affiliation: c Department of Radiology, University of Eastern Piedmont, Novara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Perchinunno
authors.affiliation: a Department of Neurology, University of Eastern Piedmont, Novara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cantello
mesh_terms: D017209:Apoptosis; D001706:Biopsy; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D003287:Contrast Media; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005682:Gadolinium; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008775:Methylprednisolone / Q000627:therapeutic use; D008959:Models, Neurological; D059906:Neuroimaging / Q000379:methods*; D009836:Oligodendroglia / Q000473:pathology; D009942:Organometallic Compounds; D066127:White Matter / Q000473:pathology
chemical_list: D003287:Contrast Media; D007166:Immunosuppressive Agents; D009942:Organometallic Compounds; C090600:gadobutrol; D005682:Gadolinium; D008775:Methylprednisolone
keywords: ADC; Balò's sclerosis; MRI; concentric sclerosis; diffusion