title: [Application and research progress of bio-derived hydrogels in tissue engineering].
abstract: OBJECTIVE
  To review the properties of bio-derived hydrogels and their application and research progress in tissue engineering.
  
  
  METHODS
  The literature concerning the biol-derived hydrogels was extensively reviewed and analyzed.
  
  
  RESULTS
  Bio-derived hydrogels can be divided into single-component hydro gels (collagen, hyaluronic acid, chitosan, alginate, silk fibroin, etc.) and multi-component hydrogels [Matrigel, the extract of extracellular matrix (ECM), and decellularized ECM]. They have favorable biocompatibility and bioactivity because they are mostly extracted from the ECM of biological tissue. Among them, hydrogels derived from decellularized ECM, whose composition and structure are more in line with the requirements of bionics, have incomparable advantages and prospects. This kind of scaffold is the closest to the natural environment of the cell growth.
  
  
  CONCLUSIONS
  Bio-derived hydrogels have been widely used in tissue engineering research. Although there still exist many problems, such as the poor mechanical properties, rapid degradation, the immunogenicity or safety, vascularization, sterilization methods, and so on, with the deep-going study of optimization mechanism, desirable bioderived hydrogels could be obtained, and thus be applied to clinical application.
authors.forename: Yuehe
authors.initials: Y
authors.lastname: Fu
authors.forename: Qing
authors.initials: Q
authors.lastname: Lü
mesh_terms: D048271:Chitosan; D003094:Collagen; D004338:Drug Combinations; D005109:Extracellular Matrix / Q000737:chemistry*; D005349:Fibroins; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007797:Laminin; D011509:Proteoglycans; D047011:Silk; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
chemical_list: D004338:Drug Combinations; D020100:Hydrogels; D007797:Laminin; D011509:Proteoglycans; D047011:Silk; C059485:matrigel; D003094:Collagen; D005349:Fibroins; D048271:Chitosan