title: [Current approaches for early detection and treatment of medication-related osteonecrosis of jaw].
abstract: Owing to the increased life expectancy, the incidence of rheumatoid disorders and oncologic cases with bone metastasis has dramatically increased. Despite the beneficial effects of the applied antiresorptive and antiangiogenic drugs (e.g. bisphosphonates), serious side effects such as jaw osteonecrosis may also develop. The aim of the authors was to summarize present knowledge about the possibilities of prevention and treatment in medication-related osteonecrosis of the jaw. Based on literature data, currently used detection methods for medication-related osteonecrosis of the jaw (including their advantages and limitations) are summarized. In addition, novel trends of surgical and adjuvant therapeutic approaches are also reviewed. The authors conclude that possibilities of prevention and efficacy of therapeutic interventions in this disorder are still limited possibly due to an incomplete knowledge of the underlying pathomechanism. An interdisciplinary cooperation for prevention and attentive monitoring in order to decrease the incidence of iatrogenic oral and maxillofacial complications seems to be particularly important.
authors.affiliation: Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar Arc-, Állcsont- és Szájsebészeti Klinika Szeged Kálvária sgt. 57. 6725.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Janovszky
authors.affiliation: Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar Arc-, Állcsont- és Szájsebészeti Klinika Szeged Kálvária sgt. 57. 6725.
authors.forename: Tamás
authors.initials: T
authors.lastname: Vereb
authors.affiliation: Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar Sebészeti Műtéttani Intézet Szeged.
authors.forename: Andrea
authors.initials: A
authors.lastname: Szabó
authors.affiliation: Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar Arc-, Állcsont- és Szájsebészeti Klinika Szeged Kálvária sgt. 57. 6725.
authors.forename: József
authors.initials: J
authors.lastname: Piffkó
mesh_terms: D000700:Analgesics / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000150:complications / Q000556:secondary; D003646:Debridement; D042241:Early Diagnosis; D006801:Humans; D053685:Laser Therapy; D028022:Low-Level Light Therapy; D010126:Ozone / Q000627:therapeutic use; D010431:Pentoxifylline / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012307:Risk Factors; D012463:Saliva; D012720:Severity of Illness Index; D019379:Teriparatide / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D015415:Biomarkers; D050071:Bone Density Conservation Agents; D019379:Teriparatide; D010126:Ozone; D024502:alpha-Tocopherol; D010431:Pentoxifylline
keywords: antiangiogenic therapy; antiangiogén terápia; antiresorptiv treatment; antireszorptív kezelés; bisphosphonate; biszfoszfonát; osteonecrosis