title: The oxidative stress of Phanerochaete chrysosporium against lead toxicity.
abstract: Among the technologies for heavy metal remediation, bioremediation technology has gained extensive attention because of its low processing costs and high efficiency. The white-rot fungus Phanerochaete chrysosporium (P. chrysosporium) which has a good tolerance to heavy metals has been widely used in the heavy metal bioremediation. In order to figure out the molecular mechanisms involved in the oxidative stress of P. chrysosporium against metal toxicity, we examined the effect of Pb(2+) on the levels of reactive oxygen species and the production of malondialdehyde. Results showed that P. chrysosporium could adjust Pb-stressed condition by regulating the unique oxidation-antioxidation process in cells and kept a balance between oxidation and antioxidation when it was threatened by a different dose of Pb(2+). Investigations into the oxidative stress of P. chrysosporium to lead could not only provide a better understanding of the relationship between lead and oxidative stress in P. chrysosporium, but also offer important informations on the development of fungal-based remediation technologies to reduce the toxic effects of lead.
authors.affiliation: College of Environmental Science and Engineering, Hunan University, Changsha, 410082, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wan
authors.forename: Guangming
authors.initials: G
authors.lastname: Zeng
authors.forename: Danlian
authors.initials: D
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.forename: Cui
authors.initials: C
authors.lastname: Lai
authors.forename: Ningjie
authors.initials: N
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wei
authors.forename: Piao
authors.initials: P
authors.lastname: Xu
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: He
authors.forename: Mingyong
authors.initials: M
authors.lastname: Lai
authors.forename: Yibin
authors.initials: Y
authors.lastname: He
mesh_terms: D001673:Biodegradation, Environmental; D002413:Cations, Divalent; D004785:Environmental Pollutants / Q000737:chemistry* / Q000378:metabolism; D007854:Lead / Q000737:chemistry* / Q000378:metabolism; D008315:Malondialdehyde / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D020075:Phanerochaete / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D004785:Environmental Pollutants; D017382:Reactive Oxygen Species; D007854:Lead; D008315:Malondialdehyde