title: Successful pregnancy and delivery via in vitro fertilization with cryopreserved and thawed embryo transfer in an acute myeloid leukemia patient after allogeneic bone marrow transplantation.
abstract: As the number of young long-term survivors of hematopoietic stem cell transplantation (HSCT) for acute leukemia continues to increase, post-transplant infertility is becoming a significant concern. HSCT, particularly with cyclophosphamide and total body irradiation conditioning, is known to cause secondary premature ovarian failure, resulting in infertility. To preserve post-transplant fertility, several methods have been proposed, including in vitro fertilization (IVF) with embryo cryopreservation. Due to the aggressiveness of acute leukemia, however, patients have little chance to undergo egg harvesting and IVF before they must begin receiving chemotherapy. To the best of our knowledge, there have been no detailed reports of successful pregnancy after HSCT using IVF with embryo cryopreservation and transfer in a patient with acute myeloid leukemia. Here, we report the case of a 42-year-old woman with acute myeloid leukemia who became pregnant 2 years and 2 months after allogeneic bone marrow transplantation via IVF-embryo transfer with an egg collected after induction therapy and delivered a full-term healthy infant.
authors.affiliation: Department of Hematology, Yokohama City University Medical Center, Minami-ku Urafune-cho 4-57, Yokohama, Kanagawa, 232-0024, Japan, yuki1234@yokohama-cu.ac.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kishimoto
authors.forename: Ayumi
authors.initials: A
authors.lastname: Numata
authors.forename: Kenji
authors.initials: K
authors.lastname: Motohashi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamashita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D015925:Cryopreservation; D036861:Delivery, Obstetric; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000628:therapy*; D050498:Live Birth; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D014184:Transplantation, Homologous