title: Holistic atlases of functional networks and interactions reveal reciprocal organizational architecture of cortical function.
abstract: For decades, it has been largely unknown to what extent multiple functional networks spatially overlap/interact with each other and jointly realize the total cortical function. Here, by developing novel sparse representation of whole-brain fMRI signals and by using the recently publicly released large-scale Human Connectome Project high-quality fMRI data, we show that a number of reproducible and robust functional networks, including both task-evoked and resting state networks, are simultaneously distributed in distant neuroanatomic areas and substantially spatially overlapping with each other, thus forming an initial collection of holistic atlases of functional networks and interactions (HAFNIs). More interestingly, the HAFNIs revealed two distinct patterns of highly overlapped regions and highly specialized regions and exhibited that these two patterns of areas are reciprocally localized, revealing a novel organizational principle of cortical function.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Lv
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Shijie
authors.initials: S
authors.lastname: Zhao
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.forename: Junwei
authors.initials: J
authors.lastname: Han
authors.forename: Jieping
authors.initials: J
authors.lastname: Ye
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055815:Young Adult