title: Integration of microstructured scaffolds, neurons, and multielectrode arrays.
abstract: Recent progresses in neuroelectronics and lab-on-a-chip technologies are providing novel opportunities for neuroscience research and applications. However, the experimental performances of these novel devices are not only the result of the artificially implemented features, such as those resulting from advanced electrode materials, from electrode morphologies, or from the low noise levels of the front-end electronic circuits. Rather, these performances also strictly relay on the bioartificial interface established by neurons on these devices. Here, we focus on cell culture systems adapted to neuroelectronic devices that were developed for organizing and growing neural networks in two or three dimensions. These developments span the fields of biosensors, engineering, neuroscience, and novel nanostructures and materials. Additionally, they are at the origin of novel neuroartificial hybrid technologies that can be applied for the study of neuronal networks at unprecedented scales and for applications in neuroscience that use scaffolding micro-/nanostructures, neurons, and biomolecules for advanced neuroelectronic interfaces and novel cell culture systems.
authors.affiliation: Istituto Italiano di Tecnologia, NetS(3) Laboratory, Neuroscience and Brain Technologies Dpt., Genova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Simi
authors.affiliation: Istituto Italiano di Tecnologia, NetS(3) Laboratory, Neuroscience and Brain Technologies Dpt., Genova, Italy.
authors.forename: Hayder
authors.initials: H
authors.lastname: Amin
authors.affiliation: Istituto Italiano di Tecnologia, NetS(3) Laboratory, Neuroscience and Brain Technologies Dpt., Genova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maccione
authors.affiliation: Istituto Italiano di Tecnologia, NetS(3) Laboratory, Neuroscience and Brain Technologies Dpt., Genova, Italy.
authors.forename: Thierry
authors.initials: T
authors.lastname: Nieus
authors.affiliation: Istituto Italiano di Tecnologia, NetS(3) Laboratory, Neuroscience and Brain Technologies Dpt., Genova, Italy. Electronic address: Luca.Berdondini@iit.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Berdondini
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D004566:Electrodes; D049329:Nanostructures; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D054457:Tissue Scaffolds
keywords: 2D and 3D neural cultures; Biofunctionalization; Multielectrode arrays; Physical and chemical network structuring