title: Paclitaxel-eluting stents for the treatment of femoropopliteal arterial stenoses: focus on the Zilver PTX drug-eluting peripheral stent.
abstract: Restenosis is one of the major limitations of the percutaneous treatment of peripheral artery disease, leading to the need for repeat interventions, limb loss and increased cost of therapy. The current standard of percutaneous treatment of stenotic lesions in the femoropopliteal arterial segment includes balloon angioplasty and bare-metal stenting. Recently, research in the field adapting the coronary arterial bed treatment model led to the inclusion of antimitotic drugs in the form of drug-eluting stents to combat neointimal proliferation and reduce the burden of restenosis. Randomized trial and registry data emerged indicating improved long-term outcomes with drug-eluting stents in peripheral arteries, lending the way to more widespread adaptation of this modality in the management of patients with peripheral artery disease.
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH, 43614, USA.
authors.forename: George V
authors.initials: GV
authors.lastname: Moukarbel
authors.forename: Mark W
authors.initials: MW
authors.lastname: Burket
mesh_terms: D002986:Clinical Trials as Topic; D003251:Constriction, Pathologic; D054855:Drug-Eluting Stents / Q000191:economics; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D017239:Paclitaxel / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D058729:Peripheral Arterial Disease / Q000188:drug therapy*; D011150:Popliteal Artery / Q000187:drug effects / Q000473:pathology*
chemical_list: D017239:Paclitaxel
keywords: angioplasty; drug-eluting stent; peripheral artery disease