title: A new oxathiolane from Enterobacter cloacae.
abstract: Enterobacter cloacae is a versatile bacterial species inhabiting a wide variety of niches and is capable of metabolising a wide variety of substances as energy resources. The fermentation culture of this bacterial species has successfully yielded one new compound, Rimboxa (1) and three known compounds, i.e. indole-3-carboxaldehyde (2), indole-3-acetic acid (3) and 3,4-di-t-butylaniline (4). Rimboxa (1) is shown to possess the 1,2-oxathiolane core structure. 3,4-Di-t-butylaniline (4) is isolated for the first time from a natural resource. These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations.
authors.affiliation: a Chemistry Department , Faculty of Science, University of Malaya , Kuala Lumpur 50603 , Malaysia.
authors.forename: Ann-Chee
authors.initials: AC
authors.lastname: Yap
authors.forename: Wuen-Yew
authors.initials: WY
authors.lastname: Teoh
authors.forename: Kok-Gan
authors.initials: KG
authors.lastname: Chan
authors.forename: Kae-Shin
authors.initials: KS
authors.lastname: Sim
authors.forename: Yeun-Mun
authors.initials: YM
authors.lastname: Choo
mesh_terms: D045744:Cell Line, Tumor; D016972:Enterobacter cloacae / Q000737:chemistry*; D006801:Humans; D007210:Indoleacetic Acids / Q000737:chemistry / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013876:Thiophenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D007210:Indoleacetic Acids; D007211:Indoles; D013876:Thiophenes; C000598303:rimboxa; C030737:indoleacetic acid; C012381:indole-3-carbaldehyde
keywords: Enterobacter cloacae; Rimboxa; oxathiolane; spectroscopic analysis