title: Two new triterpenoids from Nauclea officinalis.
abstract: Two new triterpenoids and three 27-nor-triterpenoids were isolated from the stems (with bark) of Nauclea officinalis. Their structures were identified to be 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-oic acid (1), 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-O-[β-D-glucopyranosyl (1-2)-β-D-glucopyranosyl] ester (2), pyrocincholic acid 3β-O-α-L-rhamnopyranoside (3), pyrocincholic acid 3β-O-α-L-rhamnopyranosy 1-28-O-β-D-glucopyranosyl ester (4), pyrocincholic acid 3β-O-α-L-rhamnopyranosy1-28-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosyl ester (5) by spectroscopic methods including 1D, 2D NMR and HR-MS analyses. The cytotoxic activity of 1-5 against lung cancer A-549 cells was also investigated.
authors.affiliation: a Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences , Ji'nan , Shandong 250062 , PR China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Ru-Xia
authors.initials: RX
authors.lastname: Wang
authors.forename: San-Hai
authors.initials: SH
authors.lastname: Qin
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Wang
authors.forename: Jing-Yong
authors.initials: JY
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D014315:Triterpenes
keywords: Nauclea officinalis; Rubiaceae; pyrocincholic acid; triterpenoid