title: Inflammatory response and neuronal necrosis in rats with cerebral ischemia.
abstract: In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. In the present study, we investigated the pathological changes in a rat model of middle cerebral artery occlusion. Neuronal necrosis appeared 12 hours after middle cerebral artery occlusion, and the peak of neuronal apoptosis appeared 4 to 6 days after middle cerebral artery occlusion. Inflammatory cytokines and microglia play a role in damage and repair after middle cerebral artery occlusion. Serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia.
authors.affiliation: Nanchang University Medical College, Nanchang, Jiangxi Province, China ; Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China.
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Wu
authors.affiliation: Nanchang University Medical College, Nanchang, Jiangxi Province, China.
authors.forename: Kunnan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Institution of Neurology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China.
authors.forename: Guozhu
authors.initials: G
authors.lastname: Hu
authors.affiliation: Institution of Neurology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Yan
authors.affiliation: Institution of Neurology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.affiliation: Nanchang University Medical College, Nanchang, Jiangxi Province, China.
authors.forename: Xiaomu
authors.initials: X
authors.lastname: Wu
keywords: NSFC grant; blood-brain barrier; inflammatory reactions; intercellular cell adhesion molecule-1; microglia; middle cerebral artery occlusion; nerve regeneration; neural regeneration; neurons