title: The use of antidepressants and the risk of chronic atrial fibrillation.
abstract: Serotonin stimulation of the 5HT4 receptor might be responsible for an increased risk of atrial fibrillation (AF). Thus, we assessed whether the use of antidepressants (ADs) is associated with an increased risk of chronic AF (cAF). Using the UK Clinical Practice Research Datalink, a nested case-control analysis was conducted within a cohort of new AD users having a diagnosis of depression and/or anxiety. Cases of cAF occurring during follow-up were individually matched with up to 10 controls on age, sex, year of cohort entry, and duration of follow-up. Conditional logistic regression was used to estimate rate ratios (RRs) and 95% confidence intervals (CIs) of cAF associated with current and recent use of ADs, when compared to past use. The cohort included 116,125 new AD users, of whom 1,271 were diagnosed with cAF during follow-up (incidence rate: 1.6 per 1,000 person-years). The adjusted RR of cAF associated with current and recent use of ADs was 0.98 (95%CI: 0.86-1.12) and 1.02 (95%CI: 0.86-1.30), respectively. No association was observed when ADs were classified according to their potency in reducing serotonin reuptake. These findings suggest that exposure to ADs is not associated with an increased risk of cAF.
authors.affiliation: Health Search, Italian College of General Practitioners, Florence, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Lapi
authors.forename: Laurent
authors.initials: L
authors.lastname: Azoulay
authors.forename: Abbas
authors.initials: A
authors.lastname: Kezouh
authors.forename: Jacques
authors.initials: J
authors.lastname: Benisty
authors.forename: Ilan
authors.initials: I
authors.lastname: Matok
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mugelli
authors.forename: Samy
authors.initials: S
authors.lastname: Suissa
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D001281:Atrial Fibrillation / Q000139:chemically induced* / Q000150:complications; D016022:Case-Control Studies; D016208:Databases, Factual; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D012306:Risk
chemical_list: D000928:Antidepressive Agents
keywords: antidepressants; chronic atrial fibrillation; nested case-control study; serotonin