title: Occurrence of Autoimmune Diseases Related to the Vaccine against Yellow Fever.
abstract: Yellow fever is an infectious disease, endemic in South America and Africa. This is a potentially serious illness, with lethality between 5 and 40% of cases. The most effective preventive vaccine is constituted by the attenuated virus strain 17D, developed in 1937. It is considered safe and effective, conferring protection in more than 90% in 10 years. Adverse effects are known as mild reactions (allergies, transaminases transient elevation, fever, headache) and severe (visceral and neurotropic disease related to vaccine). However, little is known about its potential to induce autoimmune responses. This systematic review aims to identify the occurrence of autoinflammatory diseases related to 17D vaccine administration. Six studies were identified describing 13 possible cases. The diseases were Guillain-Barré syndrome, multiple sclerosis, multiple points evanescent syndrome, acute disseminated encephalomyelitis, autoimmune hepatitis, and Kawasaki disease. The data suggest that 17D vaccination may play a role in the mechanism of loss of self-tolerance.
authors.affiliation: Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil ; CRDF, SHLN Bloco L Centro Cínico Norte II, 70910-900 Brasília, DF, Brazil.
authors.forename: Ana Cristina Vanderley
authors.initials: AC
authors.lastname: Oliveira
authors.affiliation: Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Licia
authors.initials: L
authors.lastname: Maria Henrique da Mota
authors.affiliation: Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Leopoldo Luiz
authors.initials: LL
authors.lastname: Dos Santos-Neto
authors.affiliation: Hospital Universitário Professor Edgard Santos da Universidade Federal da Bahia, 70390-700 Salvador, BA, Brazil.
authors.forename: Jozélio Freire
authors.initials: JF
authors.lastname: De Carvalho
authors.affiliation: Coordenação de Pesquisa da Fundação Oswaldo Cruz (FIOCRUZ), 41810-080 Brasília, DF, Brazil.
authors.forename: Iramaya Rodrigues
authors.initials: IR
authors.lastname: Caldas
authors.affiliation: Laboratório de Biomarcadores de Diagnóstico e Monitoração do Centro de Pesquisas René Rachou, FIOCRUZ, 21040-900 Belo Horizonte, MG, Brazil.
authors.forename: Olindo Assis
authors.initials: OA
authors.lastname: Martins Filho
authors.affiliation: Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Tauil