title: Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.
abstract: OBJECTIVE
  There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder, patients with schizophrenia, and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in patients with bipolar disorder.
  
  
  METHODS
  One hundred and fifteen patients with bipolar I disorder, 32 patients with schizophrenia, and 52 healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted, and age, sex, and intracranial volume were considered as covariates.
  
  
  RESULTS
  Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared with patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter.
  
  
  CONCLUSIONS
  Our results suggest that reduction in cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume.
authors.affiliation: AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, DHU PePsy, Créteil, France; INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Fondation Fondamental, Créteil, France; UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France.
authors.forename: C
authors.initials: C
authors.lastname: Laidi
authors.forename: M-A
authors.initials: MA
authors.lastname: d'Albis
authors.forename: M
authors.initials: M
authors.lastname: Wessa
authors.forename: J
authors.initials: J
authors.lastname: Linke
authors.forename: M L
authors.initials: ML
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Delavest
authors.forename: F
authors.initials: F
authors.lastname: Bellivier
authors.forename: A
authors.initials: A
authors.lastname: Versace
authors.forename: J
authors.initials: J
authors.lastname: Almeida
authors.forename: S
authors.initials: S
authors.lastname: Sarrazin
authors.forename: C
authors.initials: C
authors.lastname: Poupon
authors.forename: K
authors.initials: K
authors.lastname: Le Dudal
authors.forename: C
authors.initials: C
authors.lastname: Daban
authors.forename: N
authors.initials: N
authors.lastname: Hamdani
authors.forename: M
authors.initials: M
authors.lastname: Leboyer
authors.forename: J
authors.initials: J
authors.lastname: Houenou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000473:pathology*; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000473:pathology*; D012559:Schizophrenia / Q000473:pathology*; D012984:Software; D055815:Young Adult
keywords: MRI; bipolar disorder; cerebellum; psychosis; schizophrenia