title: Jiangrines A-F and jiangolide from an actinobacterium, Jiangella gansuensis.
abstract: Seven new compounds, including five pyrrol-2-aldehyde derivatives, jiangrines A-E (1-5), one indolizine derivative, jiangrine F (7), and one glycolipid, jiangolide (8), along with a known compound, pyrrolezanthine (6), were isolated from the fermentation broth of Jiangella gansuensis, an actinobacterium assigned to a novel family, Jiangellaceae, and a novel order, Jiangellales. The structures were elucidated by detailed spectroscopic analysis and through chemical methods. Compounds 1, 2, 3/4, 5, 6, and 8 demonstrated inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells, with IC50 values of 97.8, 60.7, 30.1, 54.9, 58.8, and 61.4 μM, respectively.
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University , Shenyang 110819, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Chun
authors.initials: C
authors.lastname: Gao
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Peipei
authors.initials: P
authors.lastname: Guan
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Liya
authors.initials: L
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D005227:Fatty Acids / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007212:Indolizines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D005227:Fatty Acids; D006017:Glycolipids; D007212:Indolizines; D008070:Lipopolysaccharides; D011758:Pyrroles; C000595482:jiangolide; C000595479:jiangrine A; C000595481:jiangrine F; D009569:Nitric Oxide