title: Chorangiomatosis: Evaluation of a placental vascular lesion and related clinical effects.
abstract: BACKGROUND
  Chorangiomatosis is a unique placental vascular abnormality that can cause growth retardation and even fetal demise in severe cases. In this study we aim to better understand this lesion and the possible clinical implications.
  
  
  METHODS
  In this study 170 placentas were evaluated, both grossly and microscopically. The patients' charts were reviewed and relevant clinical data were extracted. In the histological examination, presence of placental lesions including chorangiomatosis (focal, multifocal and diffuse) and chorangiosis was determined and possible correlation between placental findings and clinical outcomes investigated.
  
  
  RESULTS
  Among the 170 placentas examined, 42 cases of multifocal chorangiomatosis (25.6%), 7 cases with diffuse chorangiomatosis (4.26%), and 56 cases of focal chorangiomatosis (34.1%) were identified. We found that there is a significant correlation between multifocal/diffuse chorangiomatosis and adverse clinical outcomes including lower birth weight and NICU admission.
  
  
  CONCLUSIONS
  Chorangiomatosis can significantly affect the outcomes of pregnancy and more research is needed to better understand this lesion.
authors.affiliation: 1Department of Pathology, SUNY Downstate Medical Center , Brooklyn, NY , USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Momeni Boroujeni
authors.forename: Elham
authors.initials: E
authors.lastname: Yousefi
authors.forename: Miriam T
authors.initials: MT
authors.lastname: Vincent
authors.forename: Virginia
authors.initials: V
authors.lastname: Anderson
mesh_terms: D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors
keywords: Chorangiomatosis; Placental Vascular Lesions; Pregnancy Outcomes