title: Self-nanoemulsifying drug-delivery system for improved oral bioavailability of rosuvastatin using natural oil antihyperlipdemic.
abstract: OBJECTIVE
  The aim is improving the antihyperlipidemic activity of Rosuvastatin Calcium (Rs) through improving its solubility using self-nanoemulsifying drug delivery system (SNEDDS) containing natural oil full of unsaturated fatty acid and omega 3.
  
  
  METHODS
  A 7 × 3(2) full factorial design was adopted for optimization of oil ratio, Surfactant: Co-surfactant (S:CoS) ratio and oil:S/CoS ratio. Ternary phase diagrams were constructed for optimizing the system with drug loading (10 and 20%). The optimized SNEDD systems were evaluated according to their physical evaluation and drug release. Furthermore, the anti-hyperlipidemia efficacy was compared with commercially marketed product on rates followed by clinical study.
  
  
  RESULTS
  The system containing Tween 80:PEG 400 (3:1) and olive oil:garlic oil (1:1) as an oily phase has droplet size less than 100 nm, ZP (+23.43 ± 2.58 mV), PDI (<0.02) and cloud point (>90 °C). In vitro drug release studies showed remarkable enhancement of the Rs release from Rs-SNEDDS. The antihyperlipidemic effect of Rs-SNEDDS is greater than that of the commercial tablets and the pure drug on rates and in hyperlipidemic patients.
  
  
  CONCLUSIONS
  Rs-SNEDDS is a promising drug delivery system for improving the drug solubility and antihyperlipidemic effect using natural oils as (olive oil and garlic oil).
authors.affiliation: Pharmaceutics Department, Taif University , Taif , Saudi Arabia and.
authors.forename: Hadel A
authors.initials: HA
authors.lastname: Abo Enin
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D000818:Animals; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D000069463:Olive Oil / Q000737:chemistry; D010316:Particle Size; D044367:Phase Transition; D051381:Rats; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D012995:Solubility; D013440:Sulfides / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000498:Allyl Compounds; D004337:Drug Carriers; D004655:Emulsions; D005079:Excipients; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000069463:Olive Oil; D013440:Sulfides; D013501:Surface-Active Agents; C038491:allyl sulfide; D000068718:Rosuvastatin Calcium
keywords: Antihyperlipidemia; natural oil; rosuvastatin calcium; self-nanoemulsifying drug delivery system