title: The fabrication of nanocomposites via calcium phosphate formation on gelatin-chitosan network and the gelatin influence on the properties of biphasic composites.
abstract: A novel biodegradable polymer-ceramic nanocomposite which consisted of gelatin (Gel), chitosan (CS), and calcium phosphate (CaP) nanoparticles was prepared based on in situ preparation method. The fabricated biocomposites were characterized by FTIR, X-ray diffraction (XRD), transmission electron microscopy (TEM) as well as scanning electron microscope with X-ray elemental analysis (SEM-EDX). The characterization results confirmed that the crystalline calcium phosphate nanoparticles were mineralized in polymeric matrix and the interaction between Ca2+ in calcium phosphate and functional groups in polymers molecular chains was formed. XRD result showed that in addition to hydroxyapatite (HA), Brushite (BR) and tricalcium phosphate (β-TCP) particles also were formed due to lack of complete penetration of the basic solution into the polymeric matrix. However, SEM image indicated that the polymeric matrix has the controlling role in the particle size of calcium phosphate. The size of particles in three component composites was about 100nm while in two component composites proved to be more in μm size. TEM observation supported SEM results and showed that the three component composites have calcium phosphate nanoparticles. The elastic modulus and compressive strength of the composites were also improved by the employment of gelatin and chitosan together, which can make them more beneficial for surgical applications.
authors.affiliation: Nanotechnology Research Institute, School of Chemical Engineering, Babol University of Technology, Babol, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Babaei
authors.affiliation: Nanotechnology Research Institute, School of Chemical Engineering, Babol University of Technology, Babol, Iran. Electronic address: mjahan@nit.ac.ir.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Jahanshahi
authors.affiliation: Nanotechnology Research Institute, School of Chemical Engineering, Babol University of Technology, Babol, Iran; School of Mechanical Engineering, Babol University of Technology, Babol, Iran.
authors.forename: Sayed Mahmood
authors.initials: SM
authors.lastname: Rabiee
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D005780:Gelatin; D048271:Chitosan; D017886:Durapatite; C020243:calcium phosphate; C018392:tricalcium phosphate; C494366:calcium phosphate, dibasic, dihydrate