title: Adaptive optics imaging of cone mosaic abnormalities in acute macular neuroretinopathy.
abstract: OBJECTIVE
  To assess the cone photoreceptor mosaic in acute macular neuroretinopathy (AMN) using adaptive optics (AO) imaging.
  
  
  METHODS
  Four patients with AMN were evaluated retrospectively by near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and a flood-illuminated retinal AO camera. Microperimetry was performed in one patient.
  
  
  RESULTS
  The cone photoreceptor density was decreased at the level of the AMN lesions. The cone mosaic disruption appeared heterogeneous and more widespread than the lesion detected in the IR-SLO and SD-OCT images. The areas of cone loss correlated with SD-OCT and microperimetry. After resolution of the AMN lesion on IR-SLO, there was incomplete recovery of the cone photoreceptor mosaic.
  
  
  CONCLUSIONS
  Cone photoreceptor damage and reconstitution were documented in vivo at the cellular level in AMN using AO imaging. AO imaging appeared more sensitive than combined IR-SLO and SD-OCT to detect and follow photoreceptor damage in patients with AMN.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mrejen
authors.forename: Claudine E
authors.initials: CE
authors.lastname: Pang
authors.forename: David
authors.initials: D
authors.lastname: Sarraf
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Goldberg
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallego-Pinazo
authors.forename: James M
authors.initials: JM
authors.lastname: Klancnik
authors.forename: John A
authors.initials: JA
authors.lastname: Sorenson
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Yannuzzi
authors.forename: K Bailey
authors.initials: KB
authors.lastname: Freund
mesh_terms: D000328:Adult; D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009887:Ophthalmoscopy; D010781:Photography; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D012607:Scotoma / Q000175:diagnosis / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult