title: MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY.
abstract: Autophagy is a process in which cellular contents are captured in specialized, membrane-bounded vesicles and delivered to lysosomes for final degradation. Most studies support an inherent connection between autophagy and survival, but increasing evidence also suggests an association between autophagy and cell death. The therapeutic potential of targeting the autophagy pathway in cancer seems clear, but specific strategies for achieving successful eradication of cancer cells are less obvious. Recent developments in the fields of autophagy and programmed cell death, nevertheless, have shed light on therapeutic strategies with significant potential. In this review, we provide an overview of the autophagy process, pathways that modulate autophagy, and promising autophagy-based therapeutic strategies for cancer.
authors.affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors.forename: Sofie
authors.initials: S
authors.lastname: Claerhout
authors.affiliation: Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors.forename: Philip L
authors.initials: PL
authors.lastname: Lorenzi
authors.affiliation: Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors.forename: John N
authors.initials: JN
authors.lastname: Weinstein
authors.affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills