title: Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
abstract: BACKGROUND
  Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease.
  
  
  METHODS
  TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR.
  
  
  RESULTS
  We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001).
  
  
  CONCLUSIONS
  Our result suggested that CYP2B6 rs707265 modified the risk of HSCR.
authors.affiliation: Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Pingfa
authors.initials: P
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.forename: Hairong
authors.initials: H
authors.lastname: Zhu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhu
authors.forename: Peng
authors.initials: P
authors.lastname: Cai
authors.forename: Weiwei
authors.initials: W
authors.lastname: Huo
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qin
authors.forename: Hongxing
authors.initials: H
authors.lastname: Li
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Weibing
authors.initials: W
authors.lastname: Tang
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D065702:Cytochrome P-450 CYP2B6 / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006627:Hirschsprung Disease / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D065702:Cytochrome P-450 CYP2B6