title: Adherence to hepatitis A virus vaccination in HIV-infected men who have sex with men.
abstract: Although vaccination against hepatitis A virus (HAV) is essential for human immunodeficiency virus (HIV)-infected patients, the uptake of HAV vaccine is reported to be very low. From 2007 to 2012, 912 HIV-infected men in Athens, Greece were screened for exposure to HAV. Two doses of an HAV vaccine were recommended to 569 eligible patients. Reminder cards with scheduled vaccination visits were given to each patient. Among eligible patients, 62.2% (354/569) received both doses. Patients who were fully vaccinated compared with non-adherent patients were natives, older, had undetectable HIV viral load, higher CD4 T cell counts and lower nadir CD4 T cell counts. Multivariate logistic regression revealed that the patient's country of origin (p = 0.024; OR = 2.712; 95% CI, 1.139-6.457), CD4 T cell count (p < 0.001) and nadir CD4 T cell count (p < 0.001) were factors directly associated with adherence. In conclusion, adherence to HAV vaccination was better than in previously published data. Because many of the factors related to vaccination completion are parameters of HIV infection, it appears that physician interest in HIV care and vaccination planning is crucial to enhancing vaccine uptake.
authors.affiliation: HIV/AIDS Unit, Department of Dermatology and Venereology, "A.Sygros" Hospital, Athens, Greece kourkounti@in.gr.
authors.forename: Sofia
authors.initials: S
authors.lastname: Kourkounti
authors.affiliation: HIV/AIDS Unit, Department of Dermatology and Venereology, "A.Sygros" Hospital, Athens, Greece.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Paparizos
authors.affiliation: HIV/AIDS Unit, Department of Dermatology and Venereology, "A.Sygros" Hospital, Athens, Greece.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Leuow
authors.affiliation: HIV/AIDS Unit, Department of Dermatology and Venereology, "A.Sygros" Hospital, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Paparizou
authors.affiliation: HIV/AIDS Unit, Department of Dermatology and Venereology, "A.Sygros" Hospital, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Antoniou
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D004305:Dose-Response Relationship, Drug; D006115:Greece; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood / Q000276:immunology; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology; D030041:Hepatitis A virus / Q000276:immunology*; D018451:Homosexuality, Male; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines
keywords: AIDS; HAV vaccine; HIV; MSM; adherence; hepatitis A; treatment; vaccination