title: A potent antimicrobial compound isolated from Clathria cervicornis.
abstract: The sponge of Clathria cervicornis is commonly used in traditional medicine. This study aims to identify the active compound in C. cervicornis and to evaluate its antimicrobial activity. The purified active compound was determined to be crambescidin 800 and was found to be highly active against Acinetobacter baumannii (minimal inhibitory concentration, MIC=2 μg/ml), Klebsiella pneumoniae (MIC=1 μg/ml) and Pseudomonas aeruginosa (MIC=1 μg/ml). A potent antimicrobial compound, crambescidin 800, was isolated in Clathria cervicornis. It is extremely active against three common pathogenic bacteria.
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Shi
authors.initials: S
authors.lastname: Sun
authors.affiliation: USDA, ARS, USHRL, 2001 S. Rock Rd, Ft. Pierce, FL 34945, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Ference
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Ninghui
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States. Electronic address: kzhou@wayne.edu.
authors.forename: Kequan
authors.initials: K
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D011161:Porifera
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001688:Biological Products
keywords: Antimicrobial activity; Clathria cervicornis; Crambescidin 800; Minimal inhibitory concentration; Natural antimicrobial