title: Large scale pedigree analysis leads to evidence for founder effects of Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca mulatta).
abstract: Hypertrophic Cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Analyses of 108 rhesus macaque probands with pronounced HCM revealed a strong genetic predisposition to this disease. Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically and anatomically.
authors.affiliation: Department of Anthropology, University of California, Davis, CA 95616 ; California National Primate Research Center, University of California, Davis, CA 95616 ; Department of Environmental Toxicology, University of California, Davis, CA 95616.
authors.forename: Sree
authors.initials: S
authors.lastname: Kanthaswamy
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Rachel
authors.initials: R
authors.lastname: Reader
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Ross
authors.initials: R
authors.lastname: Tarara
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Karen
authors.initials: K
authors.lastname: Oslund
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Mark
authors.initials: M
authors.lastname: Allen
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Jillian
authors.initials: J
authors.lastname: Ng
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Chloe
authors.initials: C
authors.lastname: Grinberg
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616 ; School of Veterinary Medicine, University of California, Davis, CA 95616.
authors.forename: Dallas
authors.initials: D
authors.lastname: Hyde
authors.affiliation: Department of Anthropology, University of California, Davis, CA 95616 ; California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: David Glenn
authors.initials: DG
authors.lastname: Glenn
authors.affiliation: California National Primate Research Center, University of California, Davis, CA 95616.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Lerche
keywords: Genetic disease; heart disease; left ventricular hypertrophy; nonhuman primates