title: Expression of MTA1 in nasopharyngeal carcinoma and its correlation with prognosis.
abstract: Metastasis-associated protein 1 (MTA1) is related to tumour metastasis and poor prognosis in various human cancers. The aim of this study was to investigate the expression of MTA1 in nasopharyngeal carcinoma (NPC) and explore the prognostic value of MTA1 in NPC patients. The expression of MTA1 in 136 human NPC tissues and 20 normal nasopharyngeal tissues was detected using immunohistochemistry, quantified and classified into low or high expression using a 50% cut-off level. The relationships of MTA1 expression with the clinical characteristics and survival of patients were analysed. MTA1-positive staining was observed in the nuclei of NPC cells, and MTA1 expression was significantly correlated with T stage (P = 0.006), clinical stage (P = 0.001) and distant metastasis (P < 0.001). Patients with high MTA1 expression exhibited significantly worse distant metastasis-free survival (DMFS) than those with low MTA1 expression (90.75% vs. 70.81%, P = 0.017). Multivariate survival analysis revealed that MTA1 expression was an independent prognostic factor for DMFS (P = 0.038). In this study, high MTA1 expression was significantly associated with poor DMFS in NPC, indicating that MTA1 could serve as a novel biomarker for assessing the metastatic potential of NPC and could act as a possible therapeutic target for the treatment of metastatic nasopharyngeal carcinoma.
authors.affiliation: Department of Radiotherapy, Affiliated Cancer Hospital of Guangzhou Medical University, No. 78, Hengzhigang Road, Yuexiu District, Guangzhou, 510095, Guangdong, China.
authors.forename: Taize
authors.initials: T
authors.lastname: Yuan
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Zhang
authors.forename: Baoqiong
authors.initials: B
authors.lastname: Liu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yin
authors.initials: Y
authors.lastname: Liang
authors.forename: Ronghui
authors.initials: R
authors.lastname: Zheng
authors.forename: Jin
authors.initials: J
authors.lastname: Deng
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma; D002467:Cell Nucleus / Q000378:metabolism; D059248:Chemoradiotherapy; D005260:Female; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012016:Reference Values; D012097:Repressor Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D016019:Survival Analysis; D015534:Trans-Activators; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C089320:MTA1 protein, human; D012097:Repressor Proteins; D015534:Trans-Activators; D006655:Histone Deacetylases