title: [A cross-sectional study of pulmonary arterial hypertension in congenital heart disease by right heart catheterization].
abstract: OBJECTIVE
  To explore the prevalence of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) and analyze its independent risk factors.
  
  
  METHODS
  During May 2007 to December 2008, a total of 704 consecutive CHD patients initially admitted into Fuwai Hospital were recruited. Their baseline data were collected and right heart catheterization (RHC) was performed. Those with a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg (1 mmHg = 0.133 kPa) during RHC were diagnosed as PAH. Multiple Logistic regression was performed to analyze the independent risk factors of PAH.
  
  
  RESULTS
  There were 319 males and 385 females with a median age of 5 years. The causes included atrial septal defect (n = 185), ventricular septal defect (VSD, n = 452), patent ductus arteriosus (PDA, n = 48) and a combinations of the above lesions (n = 19). And 280 (39.8%) CHD patients had PAH. Logistic regression analysis revealed that age, systemic artery systolic blood pressure, VSD, PDA and combined lesions were independent risk factors of PAH in CHD (age: OR = 1.017, 95%CI: 1.001-1.033, P = 0.040; systemic artery systolic blood pressure: OR = 0.959, 95%CI: 0.944-0.975, P < 0.001; VSD: OR = 4.402, 95%CI: 2.615-7.411, P < 0.001; PDA: OR = 6.417, 95%CI: 3.079-13.373, P < 0.001; combined lesions: OR = 10.513, 95%CI: 3.641-30.355, P < 0.001).
  
  
  CONCLUSIONS
  PAH is a common complication of CHD. Age, peripheral artery systolic blood pressure and type of lesion are independent risk factors of PAH in CHD.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Yunjuan
authors.initials: Y
authors.lastname: Sun
authors.forename: Kunjing
authors.initials: K
authors.lastname: Pang
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhao
authors.forename: Changming
authors.initials: C
authors.lastname: Xiong
authors.forename: Xinhai
authors.initials: X
authors.lastname: Ni
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Email: hejianguofw@gmail.com.
authors.forename: Jianguo
authors.initials: J
authors.lastname: He
mesh_terms: D001794:Blood Pressure; D006328:Cardiac Catheterization; D003430:Cross-Sectional Studies; D004374:Ductus Arteriosus, Patent; D005260:Female; D006330:Heart Defects, Congenital; D006344:Heart Septal Defects, Atrial; D006345:Heart Septal Defects, Ventricular; D006801:Humans; D006976:Hypertension, Pulmonary; D008297:Male; D011651:Pulmonary Artery; D012307:Risk Factors