title: Allergic inflammation--innately homeostatic.
abstract: Allergic inflammation is associated closely with parasite infection but also asthma and other common allergic diseases. Despite the engagement of similar immunologic pathways, parasitized individuals often show no outward manifestations of allergic disease. In this perspective, we present the thesis that allergic inflammatory responses play a primary role in regulating circadian and environmental inputs involved with tissue homeostasis and metabolic needs. Parasites feed into these pathways and thus engage allergic inflammation to sustain aspects of the parasitic life cycle. In response to parasite infection, an adaptive and regulated immune response is layered on the host effector response, but in the setting of allergy, the effector response remains unregulated, thus leading to the cardinal features of disease. Further understanding of the homeostatic pressures driving allergic inflammation holds promise to further our understanding of human health and the treatment of these common afflictions.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143.
authors.forename: Laurence E
authors.initials: LE
authors.lastname: Cheng
authors.affiliation: Department of Medicine, University of California, San Francisco, San Francisco, California 94143 Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Locksley
mesh_terms: D002940:Circadian Rhythm / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000276:immunology; D056724:Immunity, Humoral; D007249:Inflammation / Q000209:etiology / Q000276:immunology*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D010272:Parasitic Diseases / Q000150:complications*