title: Establishing a clinical and molecular diagnosis for hereditary colorectal cancer syndromes: Present tense, future perfect?
authors.affiliation: Barts Cancer Institute, John Vane Science Centre, London, United Kingdom.
authors.forename: Marnix
authors.initials: M
authors.lastname: Jansen
authors.affiliation: Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
authors.forename: Fred H
authors.initials: FH
authors.lastname: Menko
authors.affiliation: Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, USA; Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: Lodewijk A A
authors.initials: LA
authors.lastname: Brosens
authors.affiliation: Department of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
authors.affiliation: Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: G Johan
authors.initials: GJ
authors.lastname: Offerhaus
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000235:genetics*; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics; D000251:Adenosine Triphosphatases / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018450:Disease Progression; D005820:Genetic Testing / Q000379:methods; D018095:Germ-Line Mutation; D006801:Humans; D000070976:Mismatch Repair Endonuclease PMS2; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics
chemical_list: C555337:APC protein, human; D048868:Adaptor Proteins, Signal Transducing; D025601:Adenomatous Polyposis Coli Protein; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase; D000251:Adenosine Triphosphatases; C094934:PMS2 protein, human; C497172:MSH2 protein, human; D000070976:Mismatch Repair Endonuclease PMS2; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D045643:DNA Repair Enzymes