title: The road to drug resistance in Mycobacterium tuberculosis.
abstract: Sequencing of serial isolates of extensively drug-resistant tuberculosis highlights how drug resistance develops within a single patient and reveals unexpected levels of pathogen diversity.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Koch
authors.forename: Robert John
authors.initials: RJ
authors.lastname: Wilkinson
mesh_terms: D019143:Evolution, Molecular; D054908:Extensively Drug-Resistant Tuberculosis / Q000235:genetics* / Q000382:microbiology; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000472:pathogenicity; D020641:Polymorphism, Single Nucleotide