title: Multiple episodes of aspirin overdose in an individual patient: a case report.
abstract: BACKGROUND
  Aspirin overdose, though now infrequently encountered, nevertheless continues to contribute to significant morbidity and mortality. The patient described in this case report intentionally ingested overdoses of aspirin on repeated occasions. The case provided an unusual and possibly one-of-a-kind opportunity to focus on the variability in the time course of plasma salicylate concentrations with current treatment modalities of aspirin overdose in an individual patient.
  
  
  METHODS
  A 75-year-old Caucasian man who weighed 45 kg and had an extensive history of various drug overdoses and stage 3 chronic kidney disease presented to a tertiary university hospital on three occasions within 2 months after successive overdoses of aspirin. During his third admission, he overdosed with aspirin, while on the ward recovering from the previous aspirin overdose. The overdoses were categorized as "potentially lethal" on two occasions and as "serious" in the other two, based on the alleged dose of aspirin ingested (over 500 mg/kg in the first two overdoses, and 320 mg/kg and 498 mg/kg in the other two, respectively). However, as assessed by the observed salicylate concentrations, the ingestions would more appropriately have been categorized as being of "moderate" severity for the first and second overdose and "mild" severity for each of the others. This categorization was more consistent with the clinical severity of his admissions. A single dose of activated charcoal was administered only after the second overdose. On each occasion, he was given intravenous fluid with the aim of achieving euvolemia. Urinary alkalization was not attempted during the first admission, which was associated with the longest apparent elimination half-life of salicylate (30 hours). A plasma potassium concentration of approximately 4 mmol/L appeared to be needed for adequate urinary alkalization.
  
  
  CONCLUSIONS
  In a patient with impaired renal function, intravenous fluid and urinary alkalization are the mainstays of treatment of aspirin overdose. Correction of hypokalemia is recommended. Repeated doses of charcoal may be a worthwhile intervention when there is no risk of aspiration. Our experience in this case also revealed considerable unexplained variation in management despite the availability of guidelines. It is, therefore, important to monitor the implementation of available guidelines.
authors.forename: Debasish
authors.initials: D
authors.lastname: Ghosh
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Williams
authors.forename: Garry G
authors.initials: GG
authors.lastname: Graham
authors.forename: Priya
authors.initials: P
authors.lastname: Nair
authors.forename: Hergen
authors.initials: H
authors.lastname: Buscher
authors.affiliation: Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. r.day@unsw.edu.au.
authors.forename: Richard O
authors.initials: RO
authors.lastname: Day
mesh_terms: D000368:Aged; D001241:Aspirin / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000628:therapy; D008297:Male
chemical_list: D001241:Aspirin