title: A mitochondrial strategy for safeguarding the reprogrammed genome.
abstract: Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway through antioxidant supplementation.
authors.affiliation: Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, D-13125 Berlin-Buch, Germany.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Prigione
authors.affiliation: Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany ; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: James
authors.initials: J
authors.lastname: Adjaye
keywords: Antioxidants; Genomic aberrations; Mitochondria; Reprogramming; iPSCs