title: Peptide-based vectors: recent developments.
abstract: Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of cargoes through the cell membrane with low cytotoxicity. In vitro and in vivo studies have shown their possibility and full effectiveness to deliver oligonucleotides, plasmid DNA, small interfering RNAs, antibodies, and drugs. We report in this review some of the latest strategies for peptide-mediated delivery of nucleic acids. It focuses on peptide-based vectors for therapeutic molecules and on nucleic acid delivery. In addition, we discuss recent applications and clinical trials.
authors.forename: Carmine Pasquale
authors.initials: CP
authors.lastname: Cerrato
authors.forename: Tõnis
authors.initials: T
authors.lastname: Lehto
authors.forename: Ülo
authors.initials: Ü
authors.lastname: Langel
mesh_terms: D000818:Animals; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D005822:Genetic Vectors; D006801:Humans; D009696:Nucleic Acids / Q000008:administration & dosage; D009841:Oligonucleotides / Q000008:administration & dosage
chemical_list: D057846:Cell-Penetrating Peptides; D009696:Nucleic Acids; D009841:Oligonucleotides