title: Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery.
abstract: A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, PR China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Wu
authors.forename: Qingshuo
authors.initials: Q
authors.lastname: Meng
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Du
authors.forename: Lingxia
authors.initials: L
authors.lastname: Zhang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002470:Cell Survival; D015696:Gene Products, tat / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010957:Plasmids / Q000235:genetics; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman
chemical_list: D001672:Biocompatible Materials; D015696:Gene Products, tat; D008823:Micelles; D012822:Silicon Dioxide
keywords: gene delivery; large mesopores; mesoporous organosilicas; nuclear-targeted