title: Mechanisms of resistance against cancer therapeutic drugs.
abstract: Cancer is the manifestation of multiple dysregulated cellular pathways. Treatment protocols engaged in treating these diseases involve mainly the cell cycle regulating genes/proteins, DNA synthesis and repair, protein synthetic machinery, apoptotic and proliferation activity and cytoskeletal framework. Some of the traditional therapeutic strategies have over the years developed resistance making cure difficult to achieve. This paper analyzes the mechanisms employed by various cancers that render them resistant against therapeutic drugs.
authors.forename: Shailja
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Satyawan G
authors.initials: SG
authors.lastname: Damle
authors.affiliation: Department of Oral and Maxillofacial Pathology, M.M.C.D.S.R., M.M. University, Mullana (Haryana)- 133207, India. shailjachatterjee@gmail.com.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sharma
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000235:genetics / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D016147:Genes, Tumor Suppressor; D006801:Humans; D007167:Immunotherapy; D035683:MicroRNAs; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D011519:Proto-Oncogenes; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D035683:MicroRNAs; D058570:TOR Serine-Threonine Kinases