title: ALPHA glycolytic vasculogenesis better correlates with MRI and CT imaging techniques than the traditional oxygen vasculogenesis theory.
abstract: OBJECTIVE
  Traditional vasculogenesis has many contradictions related to treatment and imaging. This occurs because cancer also uses glycolysis, which does not need oxygen or arteries. Glycolytic lactate supports many procancer processes but high levels of it inhibit glycolysis.
  
  
  CONCLUSIONS
  To avoid this, lactate induces vascular growth factors that initiate glycolytic vasculogenesis ALPHA (acidic lactate sequentially induces first lymphangiogenesis, phlebogenesis, and then arteriogenesis). The sequence of vessel development is lymphatics, veins, and then arteries. Modern contrast imaging depends more on veins than arteries, which is more consistent with ALPHA than the traditional theory.
authors.affiliation: 1 Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH. 44106.
authors.forename: John R
authors.initials: JR
authors.lastname: Haaga
authors.forename: Rebecca
authors.initials: R
authors.lastname: Haaga
authors.forename: Indravadan
authors.initials: I
authors.lastname: Patel
authors.forename: Zachary
authors.initials: Z
authors.lastname: Love
authors.forename: Joseph
authors.initials: J
authors.lastname: Moulter
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005260:Female; D006019:Glycolysis; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011817:Rabbits; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019344:Lactic Acid; D010100:Oxygen
keywords: glycolysis; lactate; vascular growth factors; vasculogenesis