title: Proteasome activation delays aging and protects against proteotoxicity in neurodegenerative disease.
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Athens, Greece, sgonos@eie.gr.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Gonos
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D016922:Cellular Senescence / Q000235:genetics; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D059748:Proteolysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D016159:Tumor Suppressor Protein p53; C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex