title: Efficacy and prognostic analysis of chemoradiotherapy in patients with thoracic esophageal squamous carcinoma with cervical lymph nodal metastasis alone.
abstract: BACKGROUND
  The prognostic factors of thoracic esophageal squamous carcinoma with cervical lymph nodal metastasis (CLNM) have not been specifically investigated. This study was performed to analyze the efficacy and prognostic factors of chemoradiotherapy for thoracic esophageal carcinoma with CLNM alone.
  
  
  METHODS
  From 2002 to 2011, 139 patients with inoperable esophageal cancer who underwent chemoradiotherapy at the Sun Yat-Sen University were retrospectively analyzed. Median radiation doses were 60 Gy (range: 50-68 Gy). Univariate and multivariate analyses were performed to compare overall survival (OS) and progression-free survival (PFS).
  
  
  RESULTS
  The 1- and 3-year OS rates were 68.2% and 27.9%, respectively. The 1- and 3-year PFS rates were 51.9% and 20.1%, respectively. The multivariate analysis demonstrated that response to treatment, T stage, pathological grade, and laterality of cervical lymph nodal metastases were independent prognostic factors for thoracic esophageal carcinoma with CLNM.
  
  
  CONCLUSIONS
  Concurrent chemoradiotherapy is an important and hopeful treatment option for patients with esophageal cancer with CLNM alone. Our study has revealed that response to treatment, T stage, pathological grade and laterality of cervical lymph nodal metastases are significant prognostic factors for long-term survival.
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. zhangpeng@sysucc.org.cn.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. zhangpeng@sysucc.org.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. mianxi1982@foxmail.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. mianxi1982@foxmail.com.
authors.forename: Mian
authors.initials: M
authors.lastname: Xi
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. Leizhao1987@foxmail.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. Leizhao1987@foxmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. qiaoqiaoli1977@foxmail.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. qiaoqiaoli1977@foxmail.com.
authors.forename: Qiao-Qiao
authors.initials: QQ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. liruhe1981@foxmail.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. liruhe1981@foxmail.com.
authors.forename: Li-Ru
authors.initials: LR
authors.lastname: He
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. shiliangliu1986@foxmail.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. shiliangliu1986@foxmail.com.
authors.forename: Shi-Liang
authors.initials: SL
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. shengjingxian1980@foxmail.com.|Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. shengjingxian1980@foxmail.com.
authors.forename: Jing-Xian
authors.initials: JX
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. liumengzhong@126.com.|Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. liumengzhong@126.com.
authors.forename: Meng-Zhong
authors.initials: MZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies