title: Association between arterial stiffness and risk of coronary artery disease in a community-based population.
abstract: BACKGROUND
  Arterial stiffness is well known as an important risk factor for coronary artery disease. In this study, we aimed to investigate the association between carotid-ankle pulse wave velocity (caPWV) and risk of coronary artery disease (CAD), and the interaction between pulse wave velocity (PWV) and other potential risk factors of CAD.
  
  
  METHODS
  A community-based cross-sectional study was conducted for subjects living in Beijing, China. We collected 213 subjects with coronary artery disease and 1 266 subjects without CAD between September 2007 and January 2009 in a community center of Beijing. A multivariate Logistic regression analysis was carried out to assess the odds ratios of factors related to CAD.
  
  
  RESULTS
  We found CAD subjects were more likely to have a higher body massindex (BMI), fasting glucose, uric acid, low-density lipoprotein (LDL) cholesterol, high-sensitivity Creactive protein (hs-CRP), carotic-femoral pulse wave velocity (cfPWV) and caPWV (P < 0.05), and CAD subjects had a significantly lower HDL cholesterol levels (P < 0.05). Moreover, the proportion of hypertension in CAD subjects was significantly higher than non-CAD subjects. The multiple Logistic regression analysis showed that hypertension, higher uric acid, hs-CRP, cfPWV and caPWV levels significantly increased the risk of CAD, with ORs (CI) of 1.47 (1.25-1.74), 1.17 (1.01-1.26), 1.35 (1.10-1.67), 1.15 (1.09-1.19) and 1.07 (1.01-1.15), respectively. Higher HDL cholesterol was significantly associated with reduced risk of CAD, with ORs (CI) of 0.58 (0.40-0.83). In addition, cfPWV had significant association with age, hypertension, LDL cholesterol, with Pearson's coefficients of 0.166, 0.074, and 0.030, respectively.
  
  
  CONCLUSIONS
  cfPWV and caPWV are independently associated with significant CAD, and cfPWV has significant correlation with age and hypertension. cfPWV and caPWV may be used as a practical tool for predicting the risk of CAD.
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: yeping301@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult