title: [Ten-year evolution in non-small-cell lung cancer according to sex. Results of the KBP-2010-CPHG study by the College of General Hospital Respiratory Physicians].
abstract: BACKGROUND
  Comparison by sex and presenting features between 2000 and 2010 of the characteristics of new cases of non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Observational KBP-2010-CPHG study similar to KBP-2000-CPHG. Both studies were promoted by the French College of General Hospital Respiratory Physicians (CPHG). KBP-2010-CPHG collected data for 6083 NSCLC diagnosed between January 1st and December 31st, 2010, and followed in the respiratory departments of 119 French general hospitals.
  
  
  RESULTS
  In 2010, 24.4 % of the patients were women (16 % in 2000, p<0.0001). Compared to men, women were more commonly non-smokers (34.2 vs 4.7 %) or lighter consumers (37.2 vs 43.7 pack per years) (p<0.0001). Their tumours (mostly adenocarcinoma: 64.6 vs 48.7 %, p<0.0001) were more frequently diagnosed at stage IV (62.4 vs 56.9 %, p=0.0008). EGFR mutation research was more frequently performed (48.5 vs 31.0 %, p<0.0001) and positive (20.6 vs 5.2 %, p<0.0001) in women than men. Their treatment more frequently included targeted therapy (13.4 vs 5.7 %, p<0.0001). Compared to 2000, the percentage of non-smokers increased in men (4.7 vs 2.5 %, p<0.0001) while remaining stable in women (36.1 vs 34.2 %, p=0.32). The percentage of adenocarcinomas increased, particularly in men (48.7 vs 31.5 %, p<0.0001).
  
  
  CONCLUSIONS
  The percentage of women with NSCLC has increased in 10years in France. In 2010, the main gender differences persist, but have decreased with the increasing proportion of non-smokers and adenocarcinomas in men. Various hypotheses to explain these changes are discussed.
authors.affiliation: Service de pneumologie, hôpital Émile-Muller, 20, avenue du Docteur-René-Laennec, 68070 Mulhouse, France. Electronic address: debieuvred@ch-mulhouse.fr.
authors.forename: D
authors.initials: D
authors.lastname: Debieuvre
authors.affiliation: Service de pneumologie, centre hospitalier, 77104 Meaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Locher
authors.affiliation: Service de pneumologie, hôpital Émile-Muller, 20, avenue du Docteur-René-Laennec, 68070 Mulhouse, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Neidhardt
authors.affiliation: Service de pneumologie, unité 3, centre hospitalier, 72037 Le Mans, France.
authors.forename: F
authors.initials: F
authors.lastname: Goupil
authors.affiliation: Service de pneumologie, centre hospitalier, 45000 Orléans, France.
authors.forename: B
authors.initials: B
authors.lastname: Lemaire
authors.affiliation: Service de pneumologie, centre Saint-Joseph-Saint-Luc, 69365 Lyon, France.
authors.forename: A-S
authors.initials: AS
authors.lastname: Blanchet-Legens
authors.affiliation: Service de pneumologie, centre hospitalier des Pays-de-Morlaix, 29600 Morlaix, France.
authors.forename: D
authors.initials: D
authors.lastname: Renault
authors.affiliation: Service de pneumologie-allergologie, centre hospitalier, 59507 Douai, France.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Tavernier
authors.affiliation: Service de pneumologie, centre hospitalier, 55012 Bar-Le-Duc, France.
authors.forename: P
authors.initials: P
authors.lastname: Tagu
authors.affiliation: Service de pneumologie-oncologie thoracique, centre hospitalier intercommunal, 27023 Evreux, France.
authors.forename: H
authors.initials: H
authors.lastname: Mahmoud
authors.affiliation: Service de pneumologie et allergologie, centre hospitalier, 06130 Grasse, France.
authors.forename: M
authors.initials: M
authors.lastname: Figueredo
authors.affiliation: Service de pneumologie, centre hospitalier, 77104 Meaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Grivaux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006769:Hospitals, General; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods / Q000706:statistics & numerical data; D012737:Sex Factors
keywords: Adenocarcinoma; Adénocarcinome; Cancer bronchique non à petites cellules (CBNPC); Epidemiology; France; Non-small-cell lung cancer (NSCLC); Sex; Sexe; Épidémiologie