title: C677T gene polymorphism of MTHFR and metabolic syndrome: response to dietary intervention.
abstract: BACKGROUND
  Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were found associated with body mass index (BMI)-defined obesity and lean mass. The aim of our study was to examine the role of the C677T MTHFR gene polymorphism in the response to diet in the management of metabolic syndrome. We investigated the body composition and metabolic factor changes after an hysocaloric balanced diet (HBD), in Italian obese women affected by metabolic syndrome (MS).
  
  
  METHODS
  Forty four obese women affected by MS were eligible for the study. A HBD for 12 weeks was assigned. Study participation included a complete screening for dietary habits, anthropometry, body composition, blood biochemical markers and C677T MTHFR polymorphism genotyping. The study has been registrated by ClinicalTrials.gov Id: NCT01890070.
  
  
  RESULTS
  The highest number of responders to HBD nutritional intervention were T(-) carriers (p ≤ 0.05). In the 81% of the total population a loss of Total Body Lean was observed. A significative loss (p ≤ 0.05) of Total Body Lean was observed in the 47% of T(-) carriers and in the 53% of T(+) carriers. Diastolic and systolic blood pressure, and waist circumference were reduced (p ≤ 0.05). The prevalence of MS parameters decreased by 84% for systolic and diastolic blood pressure; 79,5% for HDL cholesterol, 82% for fasting glucose and 77% for triglycerides.
  
  
  CONCLUSIONS
  MTHFR genetic variations analysis would be an innovative tool for the nutritional assessment. Our data provide the basis for personalized dietary recommendations based on the individual's genetic makeup and nutritional status.
  
  
  BACKGROUND
  The study has been registrated by ClinicalTrials.gov Id: NCT01890070.
authors.affiliation: Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 00133, Italy. laura.di.renzo@uniroma2.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Di Renzo
authors.affiliation: Division of Legal Medicine and Social Security, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 00133, Italy. marsella.luigi@gmail.com.
authors.forename: Luigi Tonino
authors.initials: LT
authors.lastname: Marsella
authors.affiliation: Department of Agriculture, University of Naples "Federico II", Portici, 80055 (Na), Italy. francesca.sarlo@libero.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Sarlo
authors.affiliation: Department of Health Sciences, University of Milan, Milan, Italy. laura.soldati@unimi.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Soldati
authors.affiliation: Department of Surgery and Medical Science, University "Magna Græcia", Germaneto, (CZ), 88100, Italy. gratteri@unicz.it.
authors.forename: Santo
authors.initials: S
authors.lastname: Gratteri
authors.affiliation: Department of Health Science, University "Magna Græcia", Germaneto, (CZ), 88100, Italy. l.abenavoli@unicz.it.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.affiliation: Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 00133, Italy. delorenzo@uniroma2.it.|Clinic "Nuova Annunziatella", Rome, 00147, Italy. delorenzo@uniroma2.it.|I.N.Di.M, National Institute for Mediterranean Diet and Nutrigenomic, Amantea, (CS), 87032, Italy. delorenzo@uniroma2.it.
authors.forename: Antonino
authors.initials: A
authors.lastname: De Lorenzo
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)