title: Comparison of Central Corneal Thickness Measurements Obtained by RTVue OCT, Lenstar, Sirius Topography, and Ultrasound Pachymetry in Healthy Subjects.
abstract: OBJECTIVE
  To compare central corneal thickness (CCT) measurement results obtained by RTVue OCT, Lenstar, Sirius topography, and ultrasound pachymetry (UP) (OcuScan RxP Ophthalmic Ultrasound System, Alcon Laboratories) in healthy subjects.
  
  
  METHODS
  256 eyes of 128 healthy subjects were included in the study. CCT measurements were obtained from the eyes for each subject using the UP, Lenstar, Sirius topography, and RTVue OCT instruments. Ultrasound pachymetry measurements were performed after the eyes were anesthetized with one drop of 0.5% proparacaine hydrochloride and were performed at the same day after 15 minutes after previous measurements.
  
  
  RESULTS
  Of 128 participants, 84 were male and 44 were female with a mean age of 33.15 ± 12.95 years (ranging from 18 to 75 years). The mean CCTs for UP, Lenstar, Sirius topography, and RTVue OCT were 535.60 ± 35.15 (440,00-668,00); 532.63 ± 34.44 (449,00-650,00); 526.05 ± 36.45 (314,00-640,00); 525.89 ± 33.21 (437,00-646,00) µm, respectively. The mean CCT measurements were statistically different among the three groups (p = 0.002). CCT measurements obtained using RTVue-OCT were significantly thinner than those obtained using UP (p = 0.009). Sirius CCT measurements were also thinner than UP (p = 0.011). Mean CCT measurements between UP and Lenstar were similar (p = 0.769). Measurements with Lenstar (r = 0.849), Sirius topography (r = 0.883), and RTVue OCT (0.949) were highly correlated with UP measurements.
  
  
  CONCLUSIONS
  RTVue OCT and Sirius topography significantly underestimated the CCT compared with UP. Although highly correlated, the measurement values with these devices are not directly interchangeable in clinical practice.
authors.affiliation: a Department of Opthalmology , School of Medicine, Adıyaman University , Adiyaman , Turkey and.
authors.forename: Ali
authors.initials: A
authors.lastname: Şimşek
authors.affiliation: a Department of Opthalmology , School of Medicine, Adıyaman University , Adiyaman , Turkey and.
authors.forename: Şemsettin
authors.initials: Ş
authors.lastname: Bilak
authors.affiliation: a Department of Opthalmology , School of Medicine, Adıyaman University , Adiyaman , Turkey and.
authors.forename: Mete
authors.initials: M
authors.lastname: Güler
authors.affiliation: a Department of Opthalmology , School of Medicine, Adıyaman University , Adiyaman , Turkey and.
authors.forename: Musa
authors.initials: M
authors.lastname: Çapkin
authors.affiliation: b Department of Ophthalmology , Adıyaman University Education and Research Hospital , Adiyaman , Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Bilgin
authors.affiliation: a Department of Opthalmology , School of Medicine, Adıyaman University , Adiyaman , Turkey and.
authors.forename: Ali Hakim
authors.initials: AH
authors.lastname: Reyhan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001699:Biometry; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry; D019781:Corneal Topography; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence
keywords: Central corneal thickness; Lenstar; Pachymetry; RTVue OCT; Sirius topography