title: Hemorrhagic complications of dental extractions in 181 patients undergoing double antiplatelet therapy.
abstract: OBJECTIVE
  There is limited information on hemorrhagic complications during invasive dental procedures in patients treated with double antiplatelet therapy. The objective of this study is to assess the frequency of hemorrhagic complications of patients taking dual antiplatelet medication undergoing dental extractions.
  
  
  METHODS
  An observational, multicenter, prospective, cohort study was performed in 11 oral and dental care units of primary care. The study sample was derived from the population of patients aged 18 years or older who were undergoing double antiplatelet therapy and presented to the oral and dental care units requiring dental extraction. Double antiplatelet therapy is the combination of 100 mg per day of acetylsalicylic acid and a second antiplatelet agent. The predictor variables were type of extraction performed, number of extracted teeth, number of extracted roots, and presence of inflammation. The primary outcome variable was intraoperative hemorrhage, and the secondary outcome variables were hemorrhage at 24 hours and hemorrhage at 10 days. First, a univariate analysis that considered all studied variables was performed. All variables with P < .25 in the univariate analysis were included in a multivariate analysis. The association between hemorrhage severity and its relevant factors was evaluated using logistic regression analysis.
  
  
  RESULTS
  The study included 181 patients. Light hemorrhage (<30 minutes) was observed in 165 patients (91.2%). Intraoperative hemorrhage lasted more than 30 minutes in 15 patients (8.3%) and more than 60 minutes in only 1 patient, whose hemorrhage was controlled by local hemostatic measures. The presence of inflammation and 3-root extractions increased the probability of hemorrhage persisting for more than 30 minutes by factors of 10 and 7.3, respectively.
  
  
  CONCLUSIONS
  In 8.3% of patients treated with dual antiplatelet therapy, dental extractions cause hemorrhagic complications lasting more than 30 minutes are resolved using local hemostatic measures. The results of this study support the safety of dental extraction without withdrawal double antiplatelet therapy.
authors.forename: Olga
authors.initials: O
authors.lastname: Olmos-Carrasco
authors.forename: Victoria
authors.initials: V
authors.lastname: Pastor-Ramos
authors.forename: Rafael
authors.initials: R
authors.lastname: Espinilla-Blanco
authors.forename: Ana
authors.initials: A
authors.lastname: Ortiz-Zárate
authors.forename: Irene
authors.initials: I
authors.lastname: García-Avila
authors.forename: Elías
authors.initials: E
authors.lastname: Rodríguez-Alonso
authors.forename: Rosario
authors.initials: R
authors.lastname: Herrero-Sanjuán
authors.forename: María-Magdalena
authors.initials: MM
authors.lastname: Ruiz-García
authors.forename: Paloma
authors.initials: P
authors.lastname: Gallego-Beuter
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Sánchez-Delgado
authors.forename: Ana-Isabel
authors.initials: AI
authors.lastname: Terán-Agustín
authors.forename: Milagros
authors.initials: M
authors.lastname: Fernández-Behar
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Peña-Sainz
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011446:Prospective Studies; D014081:Tooth Extraction / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors