title: Exercise attenuates the major hallmarks of aging.
abstract: Regular exercise has multi-system anti-aging effects. Here we summarize how exercise impacts the major hallmarks of aging. We propose that, besides searching for novel pharmaceutical targets of the aging process, more research efforts should be devoted to gaining insights into the molecular mediators of the benefits of exercise and to implement effective exercise interventions for elderly people.
authors.affiliation: 1 Faculty of Health and Sport Science, University of Zaragoza , Huesca, Spain .
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.forename: Alejandro
authors.initials: A
authors.lastname: Santos-Lozano
authors.forename: Carmen
authors.initials: C
authors.lastname: Fiuza-Luces
authors.forename: María
authors.initials: M
authors.lastname: Morán
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002319:Cardiovascular System; D016922:Cellular Senescence; D044127:Epigenesis, Genetic; D015444:Exercise; D016330:Frail Elderly; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009132:Muscles / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000378:metabolism; D010809:Physical Fitness; D011788:Quality of Life; D055070:Resistance Training; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D016615:Telomere / Q000648:ultrastructure