title: Tea polyphenols may attenuate the neurocognitive impairment caused by global cerebral ischemia/reperfusion injury via anti-apoptosis.
abstract: OBJECTIVE
  Global cerebral ischemia/reperfusion (GCIR) may incur neurocognitive impairment. Tea polyphenols (TP) have strong anti-oxidant capacity. This study planned to investigate the protective effect of TP against the neurocognitive impairment caused by GCIR and its mechanism.
  
  
  METHODS
  One-stage anterior approach for cerebral four-vessel occlusion (4VO) was used to construct the GCIR model. Sprague Dawley rats were randomly classified into Sham group, GCIR group, and TP group (n = 50 per group). Besides receiving the same 4VO, the rats in TP group were treated with TP (6.4%) injection from the tail vein 30 minutes before cerebral ischemia. Morris water-maze test was used to evaluate the changes in space recognition and memory and open field activity test to assess the activity and motor function of rats. The cell apoptotic study in hippocampal CA1 region at specified time points (12, 24, 48, and 72 hours after surgery) was carried out by the flow cytometry, histology (hematoxylin and eosin staining), and immunohistochemical (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining) examinations. One-way analysis of variance and least significant difference t-test were used and statistical significance considered at P < 0.05.
  
  
  RESULTS
  Compared with the GCIR group, the TP group was significantly attenuated in the impairment of space recognition and memory caused by GCIR and so was the neuronal apoptosis in the hippocampal CA1 region (P < 0.05).
  
  
  CONCLUSIONS
  TP may attenuate the impairment of space recognition and memory caused by GCIR via anti-apoptosis.
authors.forename: Rongliang
authors.initials: R
authors.lastname: Xue
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.forename: Jianrui
authors.initials: J
authors.lastname: Lv
authors.forename: Rongguo
authors.initials: R
authors.lastname: Fu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Lei
authors.forename: Zhenni
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jiaxuan
authors.initials: J
authors.lastname: He
authors.forename: Hongxia
authors.initials: H
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Ding
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D056547:CA1 Region, Hippocampal / Q000187:drug effects; D004195:Disease Models, Animal; D020287:In Situ Nick-End Labeling; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D019965:Neurocognitive Disorders / Q000188:drug therapy*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D059808:Polyphenols / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D013662:Tea
keywords: Apoptosis; Global cerebral ischemia/reperfusion; Hippocampal CA1 region; Tea polyphenols