title: Biomarkers linking PCB exposure and obesity.
abstract: Recently the prevalence of obesity has increased dramatically across much of the world. Obesity, as a complex, multifactorial disease, and its health consequences probably result from the interplay of environmental, genetic, and behavioral factors. Several lines of evidence support the theory that obesity is programmed during early development and that environmental exposures can play a key role. We therefore hypothesize that the current epidemic might associated with the influence of chemical exposures upon genetically controlled developmental pathways, leading to metabolic disorders. Some environmental chemicals, such as PCBs and pesticide residues, are widespread in food, drinking water, soil, and they exert multiple effects including estrogenic on cellular processes; some have been shown to affect the development of obesity, insulin resistance, type 2 diabetes, and metabolic syndrome. To bring these lines of evidence together and address an important health problem, this narrative review has been primarily designed to address PCBs exposures that have linked with human disease, obesity in particular, and to assess the effects of PCBs on gene expression in a highlyexposed population. The results strongly suggest that further research into the specific mechanisms of PCBs-associated diseases is warranted.
authors.forename: Somiranjan
authors.initials: S
authors.lastname: Ghosh
authors.forename: Lubica
authors.initials: L
authors.lastname: Murinova
authors.forename: Tomas
authors.initials: T
authors.lastname: Trnovec
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Loffredo
authors.forename: Kareem
authors.initials: K
authors.lastname: Washington
authors.forename: Partha S
authors.initials: PS
authors.lastname: Mitra
authors.affiliation: 415 College Street, NW, Room 335, EE Just Hall, Washington DC-20059, USA. sdutta@howard.edu.
authors.forename: Sisir K
authors.initials: SK
authors.lastname: Dutta
mesh_terms: D015415:Biomarkers / Q000032:analysis; D052244:Endocrine Disruptors / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000633:toxicity*; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D009765:Obesity / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls