title: Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome.
abstract: Alpha-synuclein (SNCA), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.
authors.affiliation: Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA. narayan.ramakrishna@gmail.com.
authors.forename: Narayan
authors.initials: N
authors.lastname: Ramakrishna
authors.affiliation: Department of Virology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.
authors.forename: Harry C
authors.initials: HC
authors.lastname: Meeker
authors.affiliation: Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.
authors.forename: W Ted
authors.initials: WT
authors.lastname: Brown
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D019175:DNA Methylation / Q000187:drug effects; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000188:drug therapy / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D011401:Promoter Regions, Genetic; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein; D002392:Catechin; C045651:epigallocatechin gallate
keywords: Alpha-synuclein; Demethylation; Down syndrome; EGCG; Ts65Dn mice