title: Biogenic-production of SnO2 nanoparticles and its cytotoxic effect against hepatocellular carcinoma cell line (HepG2).
abstract: In this paper, we have established for the first time, the terrific efficiency of aqueous extract of agricultural waste dried peel of sugar apple (Annona squamosa) in the rapid synthesis of stable SnO2 nanoparticles. In topical years, the deployment of secondary metabolites from plant extract has emerged as a novel technology for the synthesis of various nanoparticles. In this paper, we have studied the potential of SnO2 nanoparticles assembly using agricultural waste source for the first time. The synthesized nanoparticles were characterized and confirmed as SnO2 nanoparticles by using UV-visible spectroscopy, XRD, and TEM analysis. The motivation of this study was to examine cytotoxicity study of SnO2 nanoparticles against hepatocellular carcinoma cell line (HepG2). SnO2 nanoparticles inhibited the cell proliferation in a dose- and time-dependent manner with an IC50 value of 148 μg/mL. The treated cells showed an altered morphology with increasing concentrations of SnO2 nanoparticles. Our result shows that the SnO2 nanoparticles exhibit moderate cytotoxicity towards the hepatocellular carcinoma (HepG2) at tested concentrations.
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, 632 014, India, mohanaroopan.s@gmail.com.
authors.forename: Selvaraj Mohana
authors.initials: SM
authors.lastname: Roopan
authors.forename: Subramanian Hari Subbish
authors.initials: SH
authors.lastname: Kumar
authors.forename: Gunabalan
authors.initials: G
authors.lastname: Madhumitha
authors.forename: Krishnamurthy
authors.initials: K
authors.lastname: Suthindhiran
mesh_terms: D031041:Annona / Q000737:chemistry*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D003460:Crystallization; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D053768:Metal Nanoparticles / Q000648:ultrastructure; D053758:Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017971:Tin Compounds / Q000633:toxicity*; D014961:X-Ray Diffraction
chemical_list: D010936:Plant Extracts; D017971:Tin Compounds; C045358:stannic oxide