title: Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.
abstract: We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
authors.affiliation: Pasteur Saint-Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia, zhebrun@almazovcentre.ru.
authors.forename: D A
authors.initials: DA
authors.lastname: Zhebrun
authors.forename: Areg A
authors.initials: AA
authors.lastname: Totolyan
authors.forename: A L
authors.initials: AL
authors.lastname: Maslyanskii
authors.forename: A G
authors.initials: AG
authors.lastname: Titov
authors.forename: A P
authors.initials: AP
authors.lastname: Patrukhin
authors.forename: A A
authors.initials: AA
authors.lastname: Kostareva
authors.forename: I S
authors.initials: IS
authors.lastname: Gol'tseva
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D019742:Chemokines, CC / Q000096:biosynthesis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D010003:Osteoarthritis / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D054388:Receptors, CCR / Q000096:biosynthesis* / Q000378:metabolism; D018709:Statistics, Nonparametric; D013583:Synovial Membrane / Q000378:metabolism*
chemical_list: D019742:Chemokines, CC; D012333:RNA, Messenger; D054388:Receptors, CCR