title: Parthenolide could become a promising and stable drug with anti-inflammatory effects.
abstract: The aim of this paper is to summarise the blocking effects of parthenolide on the cytokines and pathways that cause inflammation. Analyses of the chemical structure of parthenolide have tried to identify the active domains that play key roles in its anti-inflammatory activity. This review focuses on the anti-inflammatory actions of parthenolide in both in vitro and in vivo. These data will be helpful for future investigations into the effects of parthenolide on inflammation.
authors.affiliation: a Medical Faculty , Kunming University of Science and Technology , Kunming , P.R. China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Wang
authors.forename: Qiyan
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D012717:Sesquiterpenes; C002669:parthenolide
keywords: anti-inflammation; chemical structure; parthenolide; pharmacology