title: Post-stroke depression and the aging brain.
abstract: Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system affect both directly and indirectly the function in a variety of organs, including the brain, with consequent neurological (motor and sensory performance) and cognitive impairments, as well as leading to the development of various psychiatric diseases. Post-stroke depression (PSD) is among the most frequent neuropsychiatric consequences of cerebral ischemia. This review discusses several animal models used for the study of PSD and summarizes recent findings in the genomic profile of the ageing brain, which are associated with age-related disorders in the elderly. Since stroke and depression are diseases with increased incidence in the elderly, great clinical benefit may especially accrue from deciphering and targeting basic mechanisms underlying PSD. Finally, we discuss the relationship between ageing, circadian rhythmicity and PSD.
authors.affiliation: Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.
authors.forename: Gabriel R
authors.initials: GR
authors.lastname: Cojocaru
authors.affiliation: Department of Psychiatry, University of Medicine Rostock, Rostock, Germany.
authors.forename: Aurel
authors.initials: A
authors.lastname: Popa-Wagner
authors.affiliation: Faculty of Pharmacy, Chair of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, 200349 Romania.
authors.forename: Elena C
authors.initials: EC
authors.lastname: Stanciulescu
authors.affiliation: Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.
authors.forename: Loredana
authors.initials: L
authors.lastname: Babadan
authors.affiliation: Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Buga
keywords: Aging; Gene profiling; Post stroke depression; Stroke