title: Mitochondrial DNA Haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
abstract: The acquired immunodeficiency syndrome (AIDS) in humans was one of the chronic infections caused by human immunodeficiency virus (HIV), and the interactions between viral infection and mitochondrial energetic implicated that mitochondrial DNA (mtDNA) variation(s) may effect genetic susceptibility to AIDS. Thus, to illustrate the maternal genetic structure and further identify whether mtDNA variation(s) can effect HIV infection among southwest Chinese AIDS group, the whole mtDNA control region sequences of 70 AIDS patients and 480 health individuals from southwest China were analyzed here. Our results indicated the plausible recent genetic admixture results of AIDS group; comparison of matrilineal components between AIDS and matched Han groups showed that mtDNA haplogroup A (p = 0.048, OR = 3.006, 95% CI = 1.109-8.145) has a significant higher difference between the two groups; further comparison illustrated that mtDNA mutations 16,209 (p = 0.046, OR = 2.607, 95% CI = 0.988-6.876) and 16,319 (p = 0.009, OR = 2.965, 95% CI = 1.278-6.876) have significant differences between AIDS and matched control groups, and both of which were the defining variations of mtDNA haplogroup A, they further confirmed that mtDNA haplogroup A may confer genetic susceptibility to AIDS. Our results suggested that haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
authors.affiliation: a Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University , Yunnan Province , China.
authors.forename: Hua-Wei
authors.initials: HW
authors.lastname: Wang
authors.affiliation: a Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University , Yunnan Province , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: a Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University , Yunnan Province , China.
authors.forename: Ying-Lei
authors.initials: YL
authors.lastname: Miao
authors.affiliation: a Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University , Yunnan Province , China.
authors.forename: Hua-You
authors.initials: HY
authors.lastname: Luo
authors.affiliation: a Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University , Yunnan Province , China.
authors.forename: Kun-Hua
authors.initials: KH
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D044466:Asian People / Q000235:genetics*; D002681:China; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial; D004247:DNA
keywords: AIDS; genetic susceptibility; haplogroup; mtDNA