title: Survival of AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma Cohort.
abstract: Overall survival (OS) of patients with acquired immunodeficiency syndrome (AIDS)-related Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL) was analysed in the German AIDS-related-Lymphoma-Cohort-Study. Of 291 patients prospectively included between January 2005 and December 2012, 154 had DLBCL, 103 BL and 34 PBL. Two-year OS rates were similar between BL (69%) and DLBCL patients (63%) but lower for PBL patients (43%). Intermediate (Hazard ratio [HR] 4·1 95% confidence interval [CI] 1·98-8·49) or high (HR 4·92 95% CI 2·1-11·61) International Prognostic Index, bone marrow involvement (HR 1·69 95% CI 1·00-2·84) and PBL histology (HR 2·24 95% CI 1·24-4·03) were independent predictors of mortality.
authors.affiliation: First Department of Internal Medicine, University of Cologne, Cologne, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Schommers
authors.forename: Marcus
authors.initials: M
authors.lastname: Hentrich
authors.forename: Christian
authors.initials: C
authors.lastname: Hoffmann
authors.forename: Daniel
authors.initials: D
authors.lastname: Gillor
authors.forename: Alexander
authors.initials: A
authors.lastname: Zoufaly
authors.forename: Björn
authors.initials: B
authors.lastname: Jensen
authors.forename: Johannes R
authors.initials: JR
authors.lastname: Bogner
authors.forename: Jan
authors.initials: J
authors.lastname: Thoden
authors.forename: Jan-Christian
authors.initials: JC
authors.lastname: Wasmuth
authors.forename: Timo
authors.initials: T
authors.lastname: Wolf
authors.forename: Mark
authors.initials: M
authors.lastname: Oette
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Stefan
authors.initials: S
authors.lastname: Esser
authors.forename: Jörg J
authors.initials: JJ
authors.lastname: Vehreschild
authors.forename: Gerd
authors.initials: G
authors.lastname: Fätkenheuer
authors.forename: Christoph
authors.initials: C
authors.lastname: Wyen
mesh_terms: D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000276:immunology / Q000401:mortality*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D053208:Kaplan-Meier Estimate; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000276:immunology / Q000401:mortality*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000276:immunology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D055815:Young Adult
keywords: AIDS-related Burkitt lymphoma; AIDS-related diffuse large B-cell-lymphoma; AIDS-related lymphoma; AIDS-related plasmablastic lymphoma; lymphoma