title: Replicon: a software to accurately predict DNA replication timing in metazoan cells.
abstract: Eukaryotic DNA replication follows a strict temporal program where genomic loci are replicated at precise times during the S phase of the cell cycle. Yet, the mechanism in control of the timing program in metazoan cells is poorly understood. In a recent publication, the authors proposed an intuitive stochastic model of DNA replication and showed that it predicts replication timing with an accuracy approaching the level of experimental biological repeats. Here, we discuss an extended software implementation of the mechanistic model: Replicon. This package allows interested researchers to predict the global replication timing program in human cells from chromatin data.
authors.affiliation: Genetics Branch, Center for Cancer Research, National Institutes of Health Bethesda, MD, USA ; Graduate Program in Bioinformatics, Boston University Boston, MA, USA.
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Gindin
authors.affiliation: Genetics Branch, Center for Cancer Research, National Institutes of Health Bethesda, MD, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Meltzer
authors.affiliation: Genetics Branch, Center for Cancer Research, National Institutes of Health Bethesda, MD, USA.
authors.forename: Sven
authors.initials: S
authors.lastname: Bilke
keywords: DNA replication; cell cycle; mathematical modeling