title: Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.
abstract: Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here, we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fontaine
authors.affiliation: Department of Biology, Indiana University, Bloomington, IN 47405, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Pease
authors.affiliation: Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Steele
authors.affiliation: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Waterhouse
authors.affiliation: The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Neafsey
authors.affiliation: Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. The Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Sharakhov
authors.affiliation: The Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Jiang
authors.affiliation: The Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Hall
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Flaminia
authors.initials: F
authors.lastname: Catteruccia
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Evdoxia
authors.initials: E
authors.lastname: Kakani
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Sara N
authors.initials: SN
authors.lastname: Mitchell
authors.affiliation: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.
authors.forename: Yi-Chieh
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Hilary A
authors.initials: HA
authors.lastname: Smith
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: R Rebecca
authors.initials: RR
authors.lastname: Love
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
authors.forename: Mara K
authors.initials: MK
authors.lastname: Lawniczak
authors.affiliation: Department of Entomology, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Michel A
authors.initials: MA
authors.lastname: Slotman
authors.affiliation: Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA. Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Emrich
authors.affiliation: Department of Biology, Indiana University, Bloomington, IN 47405, USA. School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA. mwh@indiana.edu nbesansk@nd.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Hahn
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA. mwh@indiana.edu nbesansk@nd.edu.
authors.forename: Nora J
authors.initials: NJ
authors.lastname: Besansky
mesh_terms: D000818:Animals; D000852:Anopheles / Q000145:classification* / Q000235:genetics* / Q000254:growth & development; D059006:Chromosomes, Insect / Q000235:genetics; D019143:Evolution, Molecular; D049750:Genome, Insect; D023281:Genomics; D006801:Humans; D007303:Insect Vectors / Q000235:genetics*; D008288:Malaria / Q000635:transmission*; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011679:Pupa / Q000033:anatomy & histology / Q000254:growth & development; D014960:X Chromosome / Q000235:genetics