title: [Prenatal diagnosis of triploidy: the experience of Assaf-Harofe Medical Center].
abstract: BACKGROUND
  Triploidy (69 chromosomes) is the most common chromosomal anomaly encountered in human gestation, occurring in 1% of all conceptions. Most triploidies abort spontaneously during the 1st trimester. In cases that last, it is usually associated with fetal distress that can Lead to many obstetric complications.
  
  
  OBJECTIVE
  To assess the indications for prenatal karyotyping of triploidy during pregnancy in our medical center.
  
  
  METHODS
  This retrospective cohort study involved all singleton pregnancies diagnosed or referred to our institute because of triploidy, during the years 1998-2011.
  
  
  RESULTS
  There were 1879 cases of termination of pregnancies (TOPs). During this period 8 cases of triploidy were aborted. The main indications for prenatal karyotyping in our study group were abnormal sonographic findings during anomaly scans. In addition, in all of the triploidy cases, the NT test was normal. Also, the 1st or 2nd trimester serum markers tests for early diagnosis of trisomy 18 predicted all of the triploidy cases that performed the tests.
  
  
  CONCLUSIONS
  Our findings corresponded with other studies and show that the 1st or 2nd trimester serum markers tests for early diagnosis of trisomy 18, can lead to identification of triploidy pregnancies.
  
  
  CONCLUSIONS
  The routine screening tests applied in Israel INT, serum markers tests and 2nd trimester anomaly scans) were highly effective in the identification of triploidy pregnancies.
authors.forename: Maya Naor
authors.initials: MN
authors.lastname: Dovev
authors.forename: Zvi
authors.initials: Z
authors.lastname: Vaknin
authors.forename: Rimona
authors.initials: R
authors.lastname: Keidar
authors.forename: Orit
authors.initials: O
authors.lastname: Reish
authors.forename: Ya'akob
authors.initials: Y
authors.lastname: Melcer
authors.forename: Ya'akob
authors.initials: Y
authors.lastname: Meltzer
authors.forename: Ron
authors.initials: R
authors.lastname: Maymon
mesh_terms: D015415:Biomarkers / Q000097:blood; D002887:Chromosomes, Human, Pair 18; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007557:Israel; D007621:Karyotyping / Q000379:methods*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D057885:Triploidy; D014314:Trisomy / Q000175:diagnosis*; D000073842:Trisomy 18 Syndrome; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers