title: [The experimental evaluation of influence of exogenous melatonin on the genetic damage induced by radiation exposure].
abstract: It is shown in experiments on the rats subjected to gamma-radiation at various doses that preventive introduction of exogenous melatonin reduces the quantity ofchromosomal aberrations in cells ofbone marrow and decreases the expression of oxidative stress. After introduction of melatonin, the activity of leucocytes in peripheral blood and proliferation activity of splenocytes increase, which can play a role in the mechanisms for the genoprotective effect of the studied medication.
authors.forename: L V
authors.initials: LV
authors.lastname: Pikalova
authors.forename: V I
authors.initials: VI
authors.lastname: Legeza
authors.forename: V A
authors.initials: VA
authors.lastname: Gorbunov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000528:radiation effects
chemical_list: D000975:Antioxidants; D008550:Melatonin