title: Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius.
abstract: Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (3), 3α,12-dihydroxy-δ-cadinol (4), and 3α,6α-dihydroxyspiroax-4-ene (5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0 % and 7.0 % at 3 × 10-4M, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Yin
authors.forename: Zhen-Zhu
authors.initials: ZZ
authors.lastname: Zhao
authors.forename: Xu
authors.initials: X
authors.lastname: Ji
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu