title: Pd-Catalyzed direct C-H functionalization of imidazolones with aryl- and alkenyl halides.
abstract: Direct C-H arylation and alkenylation of 4,4'-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors.
authors.affiliation: Mickaël Muselli, Christine Baudequin, Christophe Hoarau, Laurent Bischoff Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France. christophe.hoarau@insa-rouen.fr laurent.bischoff@insa-rouen.fr.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Muselli
authors.forename: Christine
authors.initials: C
authors.lastname: Baudequin
authors.forename: Christophe
authors.initials: C
authors.lastname: Hoarau
authors.forename: Laurent
authors.initials: L
authors.lastname: Bischoff
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004791:Enzyme Inhibitors / Q000737:chemistry; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors; D006219:Halogens / Q000737:chemistry; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D004791:Enzyme Inhibitors; D006219:Halogens; D006841:Hydrocarbons, Aromatic; D007093:Imidazoles; C117197:imidazolone; D010165:Palladium; D064429:Fatty Acid Synthases