title: Molecular evolution of peste des petits ruminants virus.
abstract: Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity.
authors.forename: Murali
authors.initials: M
authors.lastname: Muniraju
authors.forename: Muhammad
authors.initials: M
authors.lastname: Munir
authors.forename: AravindhBabu R
authors.initials: AR
authors.lastname: Parthiban
authors.forename: Ashley C
authors.initials: AC
authors.lastname: Banyard
authors.forename: Jingyue
authors.initials: J
authors.lastname: Bao
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Wang
authors.forename: Chrisostom
authors.initials: C
authors.lastname: Ayebazibwe
authors.forename: Gelagay
authors.initials: G
authors.lastname: Ayelet
authors.forename: Mehdi
authors.initials: M
authors.lastname: El Harrak
authors.forename: Mana
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Geneviève
authors.initials: G
authors.lastname: Libeau
authors.forename: Carrie
authors.initials: C
authors.lastname: Batten
authors.forename: Satya
authors.initials: S
authors.lastname: Parida
mesh_terms: D000349:Africa; D000818:Animals; D019295:Computational Biology; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D016366:Open Reading Frames; D029021:Peste-des-Petits-Ruminants / Q000453:epidemiology / Q000821:virology*; D018107:Peste-des-petits-ruminants virus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D058974:Phylogeography; D017422:Sequence Analysis, DNA