title: A Synopsis of Nano-Technological Approaches Toward Anti-Epilepsy Therapy: Present and Future Research Implications.
abstract: Epilepsy is a non-communicable central nervous system disorder that affects over 60 million people worldwide. The developments in epilepsy treatment face major hurdles due to drug resistance and disease recurrence after reduction in medication. Nano-technological anti-epileptic drug (AED) delivery systems have recently garnered attention due to their ability to cross the blood brain barrier, improved selectivity and potential for sustained drug delivery to the brain. This review focuses on several nano-based AED delivery systems, including liposomes, nano-emulsions, polymeric nanoparticles, solid-lipid nanoparticles and magnetic nanoparticles. Their limitations and future prospects in terms of AED delivery to the brain are also highlighted. It is hoped that the present communication will be helpful in the identification of potential AED delivery systems based on their advantages and disadvantages.
authors.forename: Nasimudeen R
authors.initials: NR
authors.lastname: Jabir
authors.forename: Shams
authors.initials: S
authors.lastname: Tabrez
authors.forename: C K
authors.initials: CK
authors.lastname: Firoz
authors.forename: Syed Kashif
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Saleh S
authors.initials: SS
authors.lastname: Baeesa
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
authors.forename: Shazi
authors.initials: S
authors.lastname: Shakil
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia. meu.fabg@hotmail.com.
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D016503:Drug Delivery Systems; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D012008:Recurrence; D014018:Tissue Distribution
chemical_list: D000927:Anticonvulsants