title: Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones.
abstract: Amides and ketones were intramolecularly coupled in the presence of KOt-Bu/DMF. The reaction provided good yields of a variety of isoquinolinones. A reaction mechanism of radical addition and subsequent E2-elimination is proposed.
authors.affiliation: Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yanming@mail.sysu.edu.cn.
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Wei
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Lin-Miao
authors.initials: LM
authors.lastname: Ye
authors.forename: Rong-Hui
authors.initials: RH
authors.lastname: Lei
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D000577:Amides; D007659:Ketones; D015363:Quinolones