title: Interplay between 3'-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans.
abstract: BACKGROUND
  Polymorphisms in angiogenesis-related genes and metabolic syndrome (MetS) risk factors play important roles in cancer development. Moreover, recent studies have reported associations between a number of 3'-UTR polymorphisms and a variety of cancers. The aim of this study was to investigate the associations of three VEGF 3'-UTR polymorphisms (1451C > T [rs3025040], 1612G > A [rs10434], and 1725G > A [rs3025053]) and MetS with colorectal cancer (CRC) susceptibility in Koreans.
  
  
  METHODS
  A total of 850 participants (450 CRC patients and 400 controls) were enrolled in the study. The genotyping of VEGF polymorphisms was performed by TaqMan allelic discrimination assays. Cancer risks of genetic variations and gene-environment interactions were assessed by adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of multivariate logistic regression analyses.
  
  
  RESULTS
  VEGF 1451C > T was significantly associated with rectal cancer risk (Dominant model; AOR =1.58; 95% CI = 1.09 - 2.28; p = 0.015) whereas VEGF 1725G > A correlated with MetS risk (Dominant model; AOR =1.61; 95% CI =1.06 - 2.46; p = 0.026). Of the gene-environment combined effects, the interaction of VEGF 1451C > T and MetS contributed to increased rectal cancer risk (AOR = 3.15; 95% CI = 1.74 - 5.70; p < .001) whereas the combination of VEGF 1725G > A and MetS was involved with elevated colon cancer risk (AOR = 2.68; 95% CI = 1.30 - 1.55; p =0.008).
  
  
  CONCLUSIONS
  Our results implicate that VEGF 1451C > T and 1725G > A may predispose to CRC susceptibility and the genetic contributions may be varied with the presence of MetS.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Park
authors.forename: Hyo Geun
authors.initials: HG
authors.lastname: Jang
authors.forename: Jung O
authors.initials: JO
authors.lastname: Kim
authors.forename: Jisu
authors.initials: J
authors.lastname: Oh
authors.forename: So Young
authors.initials: SY
authors.lastname: Chong
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kwon
authors.forename: Eo Jin
authors.initials: EJ
authors.lastname: Kim
authors.affiliation: Institute for Clinical Research, School of Medicine, CHA University, 351, Yatap-dong, Bundang-gu, Seongnam 463-712, South Korea. doh@cha.ac.kr.
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D020413:3' Untranslated Regions; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A