title: Effect of curcumin in mice model of vincristine-induced neuropathy.
abstract: BACKGROUND
  Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity.
  
  
  OBJECTIVE
  The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model.
  
  
  METHODS
  Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days.
  
  
  RESULTS
  Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p < 0.001) and allodynia (p < 0.001); mechanical hyperalgesia (p < 0.001); functional loss (p < 0.001); and in the delayed phase of formalin test (p < 0.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p < 0.001) in antioxidant levels and in total calcium levels in vincristine-injected mice.
  
  
  CONCLUSIONS
  Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristine-induced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.
authors.affiliation: Department of Pharmacology, PSG College of Pharmacy , Coimbatore, Tamil Nadu , India.
authors.forename: Anand
authors.initials: A
authors.lastname: Babu
authors.forename: K G
authors.initials: KG
authors.lastname: Prasanth
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Balaji
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D020864:Calcium Channels, N-Type / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009437:Neuralgia / Q000139:chemically induced / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004856:Postural Balance / Q000187:drug effects; D012585:Sciatica / Q000188:drug therapy; D014750:Vincristine / Q000037:antagonists & inhibitors* / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; C500963:Cacna1b protein, mouse; D020864:Calcium Channels, N-Type; D018696:Neuroprotective Agents; D014750:Vincristine; D003474:Curcumin; D002118:Calcium
keywords: Antinociceptive; allodynia; chemotherapy; formalin test; hyperalgesia; neuroprotective; pain; sciatic functional index