title: p600/UBR4 in the central nervous system.
abstract: A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation. Recently, p600 has emerged as a critical protein in the mammalian brain with roles in neurogenesis, neuronal migration, neuronal signaling and survival. How p600 integrates these apparently unrelated functions to maintain tissue homeostasis and murine survival remains unclear. The common molecular basis underlying many of the actions of p600 suggests, however, certain conservation and transposition of these functions across systems. In this review, we summarize the central nervous system functions of p600 and propose new perspectives on its biological complexity in neuronal physiology and neurological diseases.
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 3330 Hospital Drive NW, Calgary, T2N 4N1, Canada, kalparso@ucalgary.ca.
authors.forename: Kari
authors.initials: K
authors.lastname: Parsons
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Minh Dang
authors.initials: MD
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002148:Calmodulin-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000032:analysis / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000473:pathology; D017434:Protein Structure, Tertiary; D044767:Ubiquitin-Protein Ligases
chemical_list: D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; C505833:UBR4 protein, human; D044767:Ubiquitin-Protein Ligases