title: Exploring the therapeutic potential of jellyfish venom.
abstract: The venom of certain jellyfish has long been known to be potentially fatal to humans, but it is only recently that details of the proteomes of these fascinating creatures are emerging. The molecular contents of the nematocysts from several jellyfish species have now been analyzed using proteomic MS approaches and include the analysis of Chironex fleckeri, one of the most venomous jellyfish known. These studies suggest that some species contain toxins related to peptides and proteins found in other venomous creatures. The detailed characterization of jellyfish venom is likely to provide insight into the diversification of toxins and might be a valuable resource in drug design.
authors.affiliation: Centre for Biodiscovery & Molecular Development of Therapeutics, James Cook University, Cairns, QLD 4878, Australia.
authors.forename: Norelle L
authors.initials: NL
authors.lastname: Daly
authors.forename: Jamie
authors.initials: J
authors.lastname: Seymour
authors.forename: David
authors.initials: D
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology; D003064:Cnidarian Venoms / Q000737:chemistry* / Q000627:therapeutic use; D037462:Cubozoa / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D037402:Hydrozoa / Q000378:metabolism; D010146:Pain / Q000188:drug therapy; D040901:Proteomics; D037401:Scyphozoa / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D003064:Cnidarian Venoms