title: Experimental testing of a new generation of flow diverters in sidewall aneurysms in rabbits.
abstract: OBJECTIVE
  The development of new generation flow-diverting devices will improve the result of flow diversion in challenging aneurysms. The Flow-Redirection Endoluminal Device system is a dual-layer flow-diversion device. The purpose of this study was to evaluate the effectiveness and safety of the Flow-Redirection Endoluminal Device in a sidewall aneurysm model and in the abdominal aorta in rabbits.
  
  
  METHODS
  Single Flow-Redirection Endoluminal Devices were implanted in the right common carotid artery across sidewall, vein-pouch aneurysms and within the abdominal aorta in 22 New Zealand white rabbits and followed for 1 (n = 5), 3 (n = 5), 6 (n = 4), and 12 months (n = 8). Aneurysm occlusion was graded on a 3-point scale based on digital subtraction angiography (grade I, complete occlusion; grade II, near-complete occlusion; and grade III, incomplete occlusion). Toluidine blue and basic fuchsin staining was used for the evaluation of thrombus organization within the aneurysm and neck coverage with neointima. A scanning electron microscope was used for confirmation of the patency of branch vessels along with DSA.
  
  
  RESULTS
  Grades I and II occlusion rates were noted in 19 (86%) and 3 (14%) aneurysms, respectively, which indicated a 100% rate of complete or near-complete occlusion. No parent artery and branch artery occlusion was shown on DSA. Histologic images indicated partial or complete intraluminal thrombus organization and neointima coverage across the aneurysm neck. A scanning electron microscope indicated that all the vessel branches along the length of the device remained patent.
  
  
  CONCLUSIONS
  The Flow-Redirection Endoluminal Device in experimental aneurysms demonstrated high rates of progressive and complete aneurysm occlusion while preserving the patency of branch vessels.
authors.affiliation: From the Neuroradiology Research Laboratory (Y.H.D., D.F.K.), Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Y H
authors.initials: YH
authors.lastname: Ding
authors.affiliation: MicroVention (T.T.), Tustin, California. tai.tieu@microvention.com.
authors.forename: T
authors.initials: T
authors.lastname: Tieu
authors.affiliation: From the Neuroradiology Research Laboratory (Y.H.D., D.F.K.), Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D004195:Disease Models, Animal; D019736:Prostheses and Implants; D011817:Rabbits