title: Is persistence of metabolic syndrome associated with poor health-related quality of life in non-diabetic Iranian adults? Tehran Lipid and Glucose Study.
abstract: OBJECTIVE
  Previous research showed the association between health-related quality of life and metabolic syndrome (MetS). The present study aimed to examine the impact of persistence of MetS on health-related quality of life in non-diabetic Iranian adults.
  
  
  METHODS
  This was a cross-sectional study. A representative sample of 643 non-diabetic individuals (67% female), aged ≥20 years, who participated in the Tehran Lipid and Glucose Study in 2005-2007 were recruited for the study, and categorized into four groups, those without, with transient, with intermittent and with persistent MetS. Health-related quality of life was assessed using the Iranian version of the Short Form Health Survey. MetS was diagnosed using the Joint Interim Statement criteria.
  
  
  RESULTS
  Women with transient, intermittent and persistent MetS scored lower on the Physical Component Summary than those without the syndrome (51.03 ± 1.41, 48.16 ± 1.46 and 46.58 ± 1.29 vs 52.18 ± 1.20) after adjusting for potential confounders (P = 0.04). In women, there was also a significant decreasing trend in the scores of bodily pain (P for trend = 0.006) and general health (P for trend = 0.005) across the study groups. Compared with women without MetS, the odds ratio of reporting poor health-related quality of life for women with intermittent MetS was 2.75 (95% confidence interval 1.19-6.37, P = 0.01). Among men, however, no significant difference was observed in any of the health-related quality of life domains.
  
  
  CONCLUSIONS
  Compared with women without, with transient and with persistent MetS, those with intermittent MetS reported poorer physical health-related quality of life.
authors.affiliation: Research Center for Social Determinants of Endocrine Health & Obesity Research Center Tehran, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Amiri
authors.affiliation: Research Center for Social Determinants of Endocrine Health & Obesity Research Center Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Hosseinpanah
authors.affiliation: Research Center for Social Determinants of Endocrine Health & Obesity Research Center Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Jalali-Farahani
authors.affiliation: Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences Tehran, Iran.
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Mehrabi
authors.affiliation: Mental Health Research Group, Mother and Child Health Research Centre, Iranian Institute for Health Sciences Research, ACECR Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Montazeri
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences Tehran, Iran.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
keywords: Metabolic syndrome; Persistency; Quality of life