title: Body mass index, waist-to-hip ratio, waist circumference and waist-to-height ratio cannot predict male semen quality: a report of 1231 subfertile Chinese men.
abstract: There were controversial results between obesity-associated markers and semen quality. In this study, we investigated the correlations between age, obesity-associated markers including body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and waist circumference (WC), the combination of age and obesity-associated markers, semen parameters and serum reproductive hormone levels in 1231 subfertile men. The results showed that BMI, WC, WHR and WHtR were positively related to age, and there were also positive relations between BMI, WHR, WC and WHtR and between sperm concentration (SC), total sperm count (TSC), progressive motility (PR), sperm motility and per cent of normal sperm morphology (NSM). However, age, each of obesity-associated markers and the combination of obesity-associated markers and age were unrelated to any of semen parameters including total normal-progressively motile sperm count (TNPMS). Age, BMI, WHR, WC and WHtR were negatively related to serum testosterone and SHBG levels. However, only serum LH and FSH levels were negatively related to sperm concentration, NSM and sperm motility. In a conclusion, although age and obesity have significant impacts on reproductive hormones such as testosterone, SHBG and oestradiol, semen parameters related to FSH and LH could not be influenced, indicating that obesity-associated markers could not predict male semen quality.
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.|Department of Laboratory Science, Nanjing Hospital, Jiangsu Corps, The Armed Police Force, PLA, Nanjing, China.
authors.forename: J-C
authors.initials: JC
authors.lastname: Lu
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: J
authors.initials: J
authors.lastname: Jing
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Dai
authors.affiliation: Department of Gerontology, the First Affiliated Hospital, and the Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, China.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Zhao
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: K
authors.initials: K
authors.lastname: Fan
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: G-H
authors.initials: GH
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Liang
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Ge
authors.affiliation: Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: B
authors.initials: B
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D055101:Semen Analysis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*; D013739:Testosterone / Q000097:blood; D055105:Waist Circumference; D065927:Waist-Height Ratio; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
keywords: Obesity; reproductive hormone; semen parameter