title: Adult-onset sellar and suprasellar atypical teratoid rhabdoid tumor treated with a multimodal approach: a case report.
abstract: We report a very rare case of sellar and suprasellar atypical teratoid rhabdoid tumor (ATRT) in a 42-year-old female patient. The tumor was removed subtotally with a transsphenoidal approach. Histopathologic study showed rhabdoid cells with prominent nucleoli and abundant cytoplasm. Immunohistochemistry for INI1 was completely negative in the tumor cells, consistent with ATRT. After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years. Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region. Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.
authors.affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hae Gi
authors.initials: HG
authors.lastname: Park
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Jong Hyung
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Center for Proton Therapy, National Cancer Center, Goyang, Korea.
authors.forename: Kwan Ho
authors.initials: KH
authors.lastname: Cho
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Hyeon Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. ; Department of Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. ; Department of Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Eui Hyun
authors.initials: EH
authors.lastname: Kim
keywords: Adult-onset; Atypical teratoid rhabdoid tumor; INI1; Sellar; Suprasellar