title: [Early puberty and thoracic mass: presentation of a case].
abstract: A case is reported of a 7 year old patient with progressive dyspnea and genital development according to Marshall and Tanner criteria at the G2 VP3 stage. A mass of regular and well-defined borders was found in the chest, with calcifications and cystic areas of heterogeneous content. Basal measurements of FSH, LH and testosterone were <10 mIU/mL, 12.2 mIU/mL and 724 ng/dL, respectively. α-fetoprotein was 145.1 ng/mL. Excising the tumor improved respiratory symptoms, diminished hormone levels and stopped the process of precocious puberty. Pathology of the mediastinal tumor corresponded to a germ cell tumor with a predominant component of mature teratoma and choriocarcinoma. Neoplastic causes of precocious puberty are uncommon; its diagnosis is essential in order to provide timely treatment.
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: María Nataly
authors.initials: MN
authors.lastname: Laredo Reyna
authors.affiliation: Facultad de Medicina, Universidad Nacional Federico Villareal, Lima, Perú
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Falen Bogio
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Roxana
authors.initials: R
authors.lastname: Lipa Chancolla
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Núñez Almache
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Paola
authors.initials: P
authors.lastname: Pinto
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Oscar
authors.initials: O
authors.lastname: Espinoza Robles
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Eliana
authors.initials: E
authors.lastname: Chávez
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Rojas Gabulli
authors.affiliation: Instituto Nacional de Salud del Niño, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Del Aguila Villar
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology / Q000601:surgery; D011629:Puberty, Precocious / Q000209:etiology*