title: Unilesional folliculotropic mycosis fungoides: a unique variant of cutaneous lymphoma.
abstract: BACKGROUND
  Unilesional folliculotropic mycosis fungoides (UFMF) has been rarely reported.
  
  
  OBJECTIVE
  The aim of this study was to describe our experience with UFMF.
  
  
  METHODS
  Data were collected on all patients with clinicopathological UFMF who attended the Department of Dermatology of a tertiary university-affiliated medical centre in 1996-2013 and were followed prospectively.
  
  
  RESULTS
  The sample included seven patients (five male, two female) of mean age 38 years at diagnosis; two were aged <18 years. The lesion presented as a solitary patch/plaque with follicular accentuation in five patients, an infiltrated plaque devoid of hair in one and with follicular nodules in one. Four patients had alopecia, and one, secondary anetoderma. The lesion was located on a limb in four patients, the trunk in two, and the face in one. In all cases, the atypical folliculotropic lymphocytes expressed mainly surface CD4(+). Monoclonality was detected in three of the six patients analysed. Treatment consisted of localized electron beam in five patients, all of whom had a complete response (CR), and excision in one patient. The remaining patient, a 9-year-old boy, was treated with topical psoralen and UVA with CR. The duration of follow-up was 0.5-10 years (mean 4). There were no recurrences in six patients and local recurrence in one.
  
  
  CONCLUSIONS
  UFMF presents at a young age, usually with early disease clinical morphology. The treatment goal should be cure. Our experience indicates an excellent prognosis of early UFMF with no multifocal/internal spread.
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Amitay-Laish
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Institute of Pathology, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Feinmesser
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Unit of Pediatric Dermatology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Ben-Amitai
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Department of Radiotherapy, Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Fenig
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Sorin
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Hodak
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D009182:Mycosis Fungoides / Q000473:pathology*; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000473:pathology*