title: Effects of oral carbonic adsorbent (AST-120) on kidney of early-stage chronic kidney disease rats.
abstract: OBJECTIVE
  To investigate the therapeutic effects of oral carbonic adsorbent on rats with early-stage renal failure.
  
  
  METHODS
  The early-stage renal failure model was established with three-fourth subtotal nephrectomy Wistar rats. Four weeks after the subtotal nephrectomy, the rats were randomly divided into four groups: (1) adsorbent diet (AD) rats; (2) low protein diet (LPD) group; (3) low protein and AD rats; and (4) normal diet rats as control (ctrl) group. Sham operation group is set as well. The therapeutic effects of adsorbent were examined after 15 weeks treatment.
  
  
  RESULTS
  The level of 24 hours urinary protein excretion, serum creatinine (Scr), index of glomerulosclerosis (GSI) and tubulointerstitial fibrosis score (TIFS) of rats with adsorbent or LPD treatment are significantly lower than ctrl group rats. The combination of adsorbent and LPD lowered level of 24 hours urinary protein excretion, Scr, index of GSI and TIFS compared with LPD or adsorbent treatment alone.
  
  
  CONCLUSIONS
  Both AST-120 and LPD treatment lowered the Scr and blood urea nitrogen level as well as ameliorated the proteinuria and glomerular and tubulointerstitial damage of rats with early stage renal failure. The combined treatment of oral carbonic adsorbent and LPD showed greater therapeutic effects.
authors.affiliation: Department of Nephrology, Shanghai Institute of Kidney and Dialysis, Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital , Fudan University, Shanghai , China .
authors.forename: Xiao
authors.initials: X
authors.lastname: Tan
authors.forename: Jianqiang
authors.initials: J
authors.lastname: He
authors.forename: Xuesen
authors.initials: X
authors.lastname: Cao
authors.forename: Jianzhou
authors.initials: J
authors.lastname: Zou
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Ding
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D002244:Carbon / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D018753:Diet, Protein-Restricted / Q000379:methods*; D004195:Disease Models, Animal; D016903:Drug Monitoring; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008863:Microspheres; D009392:Nephrectomy / Q000009:adverse effects* / Q000379:methods; D010087:Oxides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D010087:Oxides; D002244:Carbon; C040896:AST 120; D003404:Creatinine
keywords: AST-120; chronic kidney disease; combined treatment; early treatment; low protein diet