title: Novel preparation of controlled porosity particle/fibre loaded scaffolds using a hybrid micro-fluidic and electrohydrodynamic technique.
abstract: The purpose of this research was to produce multi-dimensional scaffolds containing biocompatible particles and fibres. To achieve this, two techniques were combined and used: T-Junction microfluidics and electrohydrodynamic (EHD) processing. The former was used to form layers of monodispersed bovine serum albumin (BSA) bubbles, which upon drying formed porous scaffolds. By altering the T-Junction processing parameters, bubbles with different diameters were produced and hence the scaffold porosity could be controlled. EHD processing was used to spray or spin poly(lactic-co-glycolic) (PLGA), polymethysilsesquioxane (PMSQ) and collagen particles/fibres onto the scaffolds during their production and after drying. As a result, multifunctional BSA scaffolds with controlled porosity containing PLGA, PMSQ and collagen particles/fibres were obtained. Product morphology was studied by optical and scanning electron microscopy. These products have potential applications in many advanced biomedical, pharmaceutical and cosmetic fields e.g. bone regeneration, drug delivery, cosmetic cream lathers, facial scrubbing creams etc.
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
authors.forename: Maryam
authors.initials: M
authors.lastname: Parhizkar
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Sofokleous
authors.forename: Eleanor
authors.initials: E
authors.lastname: Stride
authors.forename: Mohan
authors.initials: M
authors.lastname: Edirisinghe
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002417:Cattle; D003094:Collagen; D019344:Lactic Acid; D008422:Materials Testing; D045423:Microbubbles; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D057139:Nanofibers / Q000737:chemistry*; D017646:Organosilicon Compounds; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D016062:Porosity; D012710:Serum Albumin, Bovine; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D017646:Organosilicon Compounds; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; C532869:polymethylsilsesquioxane; D003094:Collagen