title: Metabolic and inflammatory genes in schizophrenia.
abstract: Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Kayla A
authors.initials: KA
authors.lastname: Chase
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Cherise
authors.initials: C
authors.lastname: Rosen
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Hannah
authors.initials: H
authors.lastname: Gin
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Olivia
authors.initials: O
authors.lastname: Bjorkquist
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Feiner
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Marvin
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
authors.forename: Sean
authors.initials: S
authors.lastname: Conrin
authors.affiliation: The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States; Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue (M/C 151), Chicago, IL 60612, United States. Electronic address: rsharma@psych.uic.edu.
authors.forename: Rajiv P
authors.initials: RP
authors.lastname: Sharma
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D050177:Overweight / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics*; D047493:PPAR alpha / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D015850:Interleukin-6; D047493:PPAR alpha; D047495:PPAR gamma; D012333:RNA, Messenger; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D014409:Tumor Necrosis Factor-alpha
keywords: Inflammation; Obesity; Schizophrenia