title: High expression of astrocyte elevated gene-1 is associated with clinical staging, metastasis, and unfavorable prognosis in gastric carcinoma.
abstract: More and more evidence has demonstrated that astrocyte elevated gene-1 (AEG-1) is tightly associated with progression, metastasis, and unfavorable prognosis in many malignancies. However, the potential biological role of AEG-1 in gastric carcinoma (GC) has not been thoroughly delineated. In the current study, we found that AEG-1 mRNA and protein levels in GC tissues were significantly higher than those in normal gastric mucosa (P < 0.05). Simultaneously, statistical analysis displayed a significant correlation of high AEG-1 mRNA and protein expressions with differentiation status, TNM staging, invasive depth, and lymph node metastasis (P < 0.05). Most importantly, expressions of AEG-1 mRNA and protein in high clinical staging and metastatic GC tissues were dramatically higher than those in low clinical staging and non-metastatic GC tissues (P < 0.05). Stepwise investigation confirmed that the survival time of the patients with high AEG-1 level was shorter than those with low AEG-1 level or negative AEG-1 staining. Taken altogether, our data presented herein suggest that AEG-1 may be a novel predictor for metastasis and prognosis of the patients with GC.
authors.affiliation: Department of General Surgery, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, 453100, China.
authors.forename: Liangpeng
authors.initials: L
authors.lastname: Dong
authors.forename: Shuang
authors.initials: S
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Lunde
authors.initials: L
authors.lastname: Zhao
authors.forename: Shuping
authors.initials: S
authors.lastname: Dong
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Caifeng
authors.initials: C
authors.lastname: Zhang
authors.forename: Shilin
authors.initials: S
authors.lastname: Han
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins