title: [Experimental study of the therapeutic efficiency of the lithium salt of glutathione disulphide in the conditions of acute external gamma-irradiation].
abstract: Experimental studies on white outbred male mice subjected to gamma-irradiation at doses LD(80/30) have found that the therapeutic use of Litan contributes to the increase (by 40-50%) in the survival rate of the animals. Introduction to irradiated animals of Litan increases the intensity of the inclusion of 3H-thymidine in the DNA of the bone marrow cells and is associated with a growing number of splenic endogenous colonies, which can testify to the stimulating influence of the drug on the proliferation and differentiation of hematopoietic cells, as well as on the deficit restoration of full-fledged mature cell forms in the peripheral blood.
authors.forename: A A
authors.initials: AA
authors.lastname: Antushevich
authors.forename: A E
authors.initials: AE
authors.lastname: Antushevich
authors.forename: A N
authors.initials: AN
authors.lastname: Grebeniuk
authors.forename: R A
authors.initials: RA
authors.lastname: Tarumov
authors.forename: V G
authors.initials: VG
authors.lastname: Antonov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D019803:Glutathione Disulfide / Q000008:administration & dosage*; D006801:Humans; D008094:Lithium / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D015996:Survival Rate; D014916:Whole-Body Irradiation
chemical_list: D011837:Radiation-Protective Agents; D008094:Lithium; D019803:Glutathione Disulfide