title: The protective effect of Capparis ovata on 6-mercaptopurine-induced hepatotoxicity and oxidative stress in rats.
abstract: Capparis ovata is a member of Capparidacaeae family has been used in phytomedicine with a lot of positive effects such as an antioxidative, antihyperlipidemic, anti-inflammatory, and antihepatotoxic agent. The aim of this study was to research the protective effect of C. ovata on 6-mercaptopurine (6-MP) induced to hepatotoxicity and oxidative stress in rats. The rats were divided into 4 groups: control, 6-MP, C. ovataovate, and 6-MP + C. ovata. A complete blood count was performed, liver function test and antioxidant enzymes levels such as superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were measured in blood before and after a 14-day test period. White blood cell and platelet counts were lower in the 6-MP group than other 3 groups (P < 0.005). Hepatic transaminase levels were higher in 6-MP group than the 3 groups (P < 0.05). Superoxide dismutase, glutathione peroxidase, and CAT levels were lower and malondialdehyde was higher in blood samples in 6-MP group than other 3 groups (P < 0.005). In conclusion, our tests were showed that C. ovata may be useful in patients receiving 6-MP therapy to prevent hepatotoxicity and in order to maintain uninterrupted therapy possibly reducing the risk of relapse. Although additional studies ensure that Capparis does not affect 6-MP antileukemic activity. We believe these results are important contribution to the literature.
authors.affiliation: Departments of *Pediatrics †Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Tuğçe
authors.initials: T
authors.lastname: Tülümen
authors.forename: Ali
authors.initials: A
authors.lastname: Ayata
authors.forename: Metehan
authors.initials: M
authors.lastname: Özen
authors.forename: Recep
authors.initials: R
authors.lastname: Sütçü
authors.forename: Duran
authors.initials: D
authors.lastname: Canatan
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D001772:Blood Cell Count; D031484:Capparis; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D015122:Mercaptopurine / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D010936:Plant Extracts; D015122:Mercaptopurine; D013482:Superoxide Dismutase