title: Antibacterial and antioxidant constituents of Acalypha wilkesiana.
abstract: This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing Klebsiella pneumoniae (700603), while corilagin was the single compound to exhibit antioxidant activity (IC50 53 μg/mL).
authors.affiliation: a Department of Basic Science , School of Science and Technology, Babcock University , Ilisan Remo , Nigeria.
authors.forename: Chinedu P
authors.initials: CP
authors.lastname: Anokwuru
authors.forename: Annamaria
authors.initials: A
authors.lastname: Sinisi
authors.forename: Amidou
authors.initials: A
authors.lastname: Samie
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
mesh_terms: D065815:Acalypha / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012765:Shikimic Acid / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D005960:Glucosides; D047348:Hydrolyzable Tannins; D010840:Phytosterols; D010936:Plant Extracts; C000600495:quadrangularic acid M; D012765:Shikimic Acid; C024603:Geraniin; C049096:corilagin
keywords: Acalypha wilkesiana; corilagin; geraniin; quadrangularic acid M; shikimic acid