title: Three new polyunsaturated lipids from a Guangxi marine sponge Haliclona sp.
abstract: Three new polyunsaturated lipids, (6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraen-3-one (1), (6Z,9Z,12Z,15Z)-1-bromooctadeca-6,9,12,15-tetraen-3-one (2), and (Z)-ethyl docos-5-enoate (3), together with two known polyunsaturated lipids, 4(Z),7(Z),10(Z)-tridecatrienoic acid (4) and (6Z,9Z,12Z,15Z)-octadeca-1,6,9,12,15-pentaen-3-one (5), were isolated from the marine sponge Haliclona sp., which was collected from Guangxi, using HSCCC and HPLC methods. Chemical structures of the five compounds were elucidated by spectroscopic techniques.
authors.affiliation: a Research Center of Basic Medical Sciences, Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Qiong
authors.initials: Q
authors.lastname: Gu
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Xu
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Xing
authors.forename: De-Jun
authors.initials: DJ
authors.lastname: Jin
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Sheng-An
authors.initials: SA
authors.lastname: Tang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry*; D008264:Macrophages; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: C000598513:(6Z,9Z,12Z,15Z)-1-bromooctadeca-6,9,12,15-tetraen-3-one; C000598512:(6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraen-3-one; C000598514:(Z)-ethyl docos-5-enoate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005231:Fatty Acids, Unsaturated
keywords: Haliclona sp; marine sponge; polyunsaturated lipids; structural elucidation