title: Signal enhancement of electrochemical biosensors via direct electrochemical oxidation of silver nanoparticle labels coated with zwitterionic polymers.
abstract: A new electrochemical label has been developed, which is made up of silver nanoparticles (AgNPs) coated with a mixture of zwitterionic and biotinylated zwitterionic polymers. These polymers improve colloidal stability in physiological medium and ensure biorecognition while direct electrochemical oxidation of silver nanoparticles strongly enhances the detection signal. The resulting hybrid nanomaterials are used as labels in the electrochemical sensing of avidin using sandwich assays elaborated using the biotin-avidin biorecognition system.
authors.affiliation: Laboratoire de Physicochimie des Polymères et Interfaces (EA2528), Institut des Matériaux, Université de Cergy-Pontoise, 5 mail Gay Lussac, 95031, Neuville-sur-Oise, France. philippe.banet@u-cergy.fr.
authors.forename: R
authors.initials: R
authors.lastname: Geagea
authors.forename: P-H
authors.initials: PH
authors.lastname: Aubert
authors.forename: P
authors.initials: P
authors.lastname: Banet
authors.forename: N
authors.initials: N
authors.lastname: Sanson
mesh_terms: D001360:Avidin / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D001710:Biotin / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D011108:Polymers; D001360:Avidin; D012834:Silver; D001710:Biotin