title: High-risk age window for mortality in children with cystic fibrosis after lung transplantation.
abstract: LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.
authors.affiliation: Department of Pediatrics, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.forename: Karen S
authors.initials: KS
authors.lastname: McCoy
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Whitson
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Mansour
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000293:Adolescent; D000367:Age Factors; D064591:Allografts; D015992:Body Mass Index; D002648:Child; D003550:Cystic Fibrosis / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: age; allograft failure; cystic fibrosis; lung transplantation; survival