title: Pancreatic carcinoma, thrombosis and mean platelet volume: single center experience from the southeast region of Turkey.
abstract: BACKGROUND
  The aim of this study was to investigate the general characteristics of patients with deep vein thrombosis (DVT) and pancreatic cancer as well as evaluate the relationship between mean platelet volume (MPV), DVT and survival.
  
  
  METHODS
  Seventy-seven patients with pancreatic cancer, who were admitted to Cukurova University Medical Faculty, Department of Medical Oncology, were enrolled in the study
  
  
  RESULTS
  The mean age was 59±20. Forty-nine (63.6%) were men and 28 women (36.4%) . Sixty-eight (88.3%) patients had adenocarcinoma and 9 (11.7%) had a malignant epithelial tumor. Thirty-six (46.7%) had liver metastasis at diagnosis. Twenty-six (33.8%) patients were alive, 20 (26%) were dead and in 31 (40.2%) the status was unknown. Only 14 (18.1%) patients had DVT. In 42 (54.5%) patients MPV values were normal, in 28 (36.4%) patients they were above normal, and in 7 (9.1%) patients they were below normal. There was no statistically significant difference between gender, tumour localization, chemotherapy and survival rates (p:0.56, p:0.11, p:0.21). There was no significant difference between DVT, gender, localisation, histological subtype, the presence of metastasis, stage and if the patient had been treated with chemotherapy (p:0.5, p:0.6, p:0.2, p:0.32, p:0.1, p:0.84). There was also no significant difference between MPV and DVT (p:0.57) but there was a significant difference between liver metastasis and DVT (p:0.02). Age, stage, the presence of metastasis and DVT were prognostic in pancreatic cancer patients.
  
  
  CONCLUSIONS
  Cases of pancreatic cancer with liver metastasis should be studied more carefully as thrombosis is more common in these patients.
authors.affiliation: Department of Medical Oncology, Bahcelievler Medical Park Hospital, Istanbul, Turkey E-mail : cigdemusul@yahoo.com.
authors.forename: Cigdem Usul
authors.initials: CU
authors.lastname: Afsar
authors.forename: Meral
authors.initials: M
authors.lastname: Gunaldi
authors.forename: Pinar
authors.initials: P
authors.lastname: Kum
authors.forename: Berksoy
authors.initials: B
authors.lastname: Sahin
authors.forename: Melek
authors.initials: M
authors.lastname: Erkisi
authors.forename: Ismail Oguz
authors.initials: IO
authors.lastname: Kara
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Berna Bozkurt
authors.initials: BB
authors.lastname: Duman
authors.forename: Vehbi
authors.initials: V
authors.lastname: Ercolak
authors.forename: Feryal
authors.initials: F
authors.lastname: Karaca
authors.forename: Ummugul
authors.initials: U
authors.lastname: Uyeturk
authors.forename: Sebnem Izmir
authors.initials: SI
authors.lastname: Guner
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000401:mortality / Q000473:pathology*; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000150:complications / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014421:Turkey; D020246:Venous Thrombosis / Q000209:etiology / Q000401:mortality / Q000473:pathology*