title: Traumatic brain injury induces elevation of Co in the human brain.
abstract: Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that follow TBI are poorly understood. We previously reported a perturbation in iron (Fe) levels following TBI. Here we report that the distribution of cobalt (Co) is modulated in post-mortem human brain following injury. We also investigated how the distribution of other biologically relevant elements changes in TBI. Cobalt is increased due to TBI while copper (Cu), magnesium (Mg), manganese (Mn), phosphorus (P), potassium (K), rubidium (Rb), selenium (Se) and zinc (Zn) remain unchanged. The elevated Co has important implications for positron emission tomography neuroimaging. This is the first demonstration of the accumulation of Co in injured tissue explaining the previous utility of (55)Co-PET imaging in TBI.
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Blaine R
authors.initials: BR
authors.lastname: Roberts
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Hare
authors.forename: Catriona A
authors.initials: CA
authors.lastname: McLean
authors.forename: Alison
authors.initials: A
authors.lastname: Conquest
authors.forename: Monica
authors.initials: M
authors.lastname: Lind
authors.forename: Qiao-Xin
authors.initials: QX
authors.lastname: Li
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: Maria-Christina
authors.initials: MC
authors.lastname: Morganti-Kossmann
authors.forename: Tony
authors.initials: T
authors.lastname: Frugier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001344:Autopsy; D001923:Brain Chemistry; D001930:Brain Injuries / Q000378:metabolism*; D003035:Cobalt / Q000032:analysis* / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000032:analysis / Q000378:metabolism; D008875:Middle Aged; D055815:Young Adult
chemical_list: D019216:Metals, Heavy; D003035:Cobalt