title: Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity.
abstract: Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro and in vivo.
authors.affiliation: Instituto de Ciencia Molecular, Universidad de Valencia, C/catedrático José Beltrán no. 2, 46980 Paterna, Valencia, Spain. Electronic address: m.paz.clares@uv.es.
authors.forename: M Paz
authors.initials: MP
authors.lastname: Clares
authors.affiliation: Unitat de Recerca, Hospital Joan XXIII, Institut de Investigacio Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.affiliation: Instituto de Ciencia Molecular, Universidad de Valencia, C/catedrático José Beltrán no. 2, 46980 Paterna, Valencia, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Blasco
authors.affiliation: Instituto de Ciencia Molecular, Universidad de Valencia, C/catedrático José Beltrán no. 2, 46980 Paterna, Valencia, Spain.
authors.forename: Aida
authors.initials: A
authors.lastname: Nebot
authors.affiliation: Departamento de Microbiología y Ecología, Facultad de Farmacia, Universidad de Valencia, C/Vicente Andrés Estellés, s/n, 46100 Burjassot, Valencia, Spain.
authors.forename: Lucas
authors.initials: L
authors.lastname: del Castillo
authors.affiliation: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, C/Vicente Andrés Estellés, s/n, 46100 Burjassot, Valencia, Spain.
authors.forename: Conxa
authors.initials: C
authors.lastname: Soriano
authors.affiliation: Departamento de Química Analítica, Universidad de Valencia, C/Dr. Moliner 50, 46100 Burjassot, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Domènech
authors.affiliation: Bionos Biotech, SL; Biopolo Hospital La Fe, Av. Bulevar Sur s/n, Valencia 46026, Spain.
authors.forename: Ana Virginia
authors.initials: AV
authors.lastname: Sánchez-Sánchez
authors.affiliation: Bionos Biotech, SL; Biopolo Hospital La Fe, Av. Bulevar Sur s/n, Valencia 46026, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Soler-Calero
authors.affiliation: Bionos Biotech, SL; Biopolo Hospital La Fe, Av. Bulevar Sur s/n, Valencia 46026, Spain; Instituto de Investigación Sanitaria Hospital La Fe, Av. Campanar 21, Valencia 46009, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mullor
authors.affiliation: Unitat de Recerca, Hospital Joan XXIII, Institut de Investigacio Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, Tarragona, Spain. Electronic address: agarciae.hj23.ics@gencat.cat.
authors.forename: Antonio
authors.initials: A
authors.lastname: García-España
authors.affiliation: Instituto de Ciencia Molecular, Universidad de Valencia, C/catedrático José Beltrán no. 2, 46980 Paterna, Valencia, Spain. Electronic address: enrique.garcia-es@uv.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D020134:Catalytic Domain; D004926:Escherichia coli / Q000201:enzymology; D029968:Escherichia coli Proteins / Q000737:chemistry; D029941:Fish Proteins / Q000737:chemistry; D008024:Ligands; D008345:Manganese / Q000737:chemistry*; D008956:Models, Chemical; D009990:Oryzias; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry; D013482:Superoxide Dismutase / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D029968:Escherichia coli Proteins; D029941:Fish Proteins; D008024:Ligands; D011804:Quinolines; D029701:Saccharomyces cerevisiae Proteins; D008345:Manganese; D013482:Superoxide Dismutase
keywords: Antioxidant activity; Bacteria; Fish embryo models; Mn(II) complexes; Polyazamacrocyclic scorpiands; Yeast