title: Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis.
abstract: BACKGROUND
  The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility.
  
  
  METHODS
  A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P<0.01).
  
  
  CONCLUSIONS
  This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.
authors.affiliation: Respiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
authors.forename: Junfei
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Respiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Respiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
authors.forename: Weizhen
authors.initials: W
authors.lastname: Hu
authors.affiliation: Respiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Jin
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D018832:Molecular Chaperones / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C092009:BAG6 protein, human; D018832:Molecular Chaperones