title: Host genetics of invasive Aspergillus and Candida infections.
abstract: Invasive candidiasis and aspergillosis are major complications in surgical and onco-hematological patients, and still associated with an important morbidity and mortality. A large number of studies highlighted the potential role of host genetic polymorphisms that may influence susceptibility to fungal pathogens, but many were limited by insufficient statistical power, problematic design, and/or lack of replication. However, some relevant polymorphisms are now emerging from well-conducted studies whose associations have been replicated and/or are supported by strong biological evidence. Such polymorphisms together with other biomarkers may play a role in the prediction, diagnosis, and management of severe fungal infections in high-risk patients in the coming years.
authors.affiliation: Infectious Disease Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wójtowicz
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Bochud
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D001230:Aspergillus / Q000276:immunology*; D002175:Candida / Q000276:immunology*; D058365:Candidiasis, Invasive / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors