title: [Ophthalmologic complications and local anesthesia. Pathophysiology and types of eye complications after intraoral dental anesthesia, and clinical recommendations].
abstract: The present article reviews the different types of ophthalmologic complications following administration of intraoral local anesthesia. Since the first report by Brain in 1936, case reports about that topic have been published regularly in the literature. However, clinical studies evaluating the incidence of ophthalmologic complications after intraoral local anesthesia are rarely available. Previous data point to a frequency ranging from 0.03% to 0.13%. The most frequently described ophthalmologic complications include diplopia (double vision), ptosis (drooping of upper eyelid), and mydriasis (dilatation of pupil). Disorders that rather affect periorbital structures than the eye directly include facial paralysis and periorbital blanching (angiospasm). Diverse pathophysiologic mechanisms and causes have been reported in the literature, with the inadvertent intravascular administration of the local anesthetic considered the primary reason. The agent as well as the vasopressor is transported retrogradely via arteries or veins to the orbit or to periorbital structures (such as the cavernous sinus) with subsequent anesthesia of nerves and paralysis of muscles distant from the oral cavity. In general the ophthalmologic complications begin shortly after administration of the local anesthesia, and disappear once the local anesthesia has subsided.
authors.affiliation: Klinik für Oralchirurgie und Stomatologie, Zahn- medizinische Kliniken der Universität Bern, Bern, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: von Arx
authors.forename: Scott
authors.initials: S
authors.lastname: Lozanoff
authors.forename: Martin
authors.initials: M
authors.lastname: Zinkernagel
mesh_terms: D000766:Anesthesia, Dental / Q000009:adverse effects*; D000772:Anesthesia, Local / Q000009:adverse effects*; D001763:Blepharoptosis / Q000139:chemically induced* / Q000503:physiopathology*; D005128:Eye Diseases / Q000139:chemically induced* / Q000503:physiopathology*; D005158:Facial Paralysis / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D015840:Oculomotor Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009886:Ophthalmoplegia / Q000139:chemically induced* / Q000503:physiopathology*; D011379:Prognosis; D012307:Risk Factors; D014786:Vision Disorders / Q000139:chemically induced* / Q000503:physiopathology*
keywords: Ophthalmologische Komplikation; intraorale Lokalanästhesie; Pathophysiologie