title: Clinicopathological characteristics and prognosis of patients according to recurrence time after curative resection for colorectal cancer.
abstract: OBJECTIVE
  To investigate clinicopathological features in patients with recurrent colorectal cancer within 1 year and more than 1 year after curative resection.
  
  
  METHODS
  We retrospectively evaluated 103 patients with disease recurrence before versus after 1 year of resection. Thirty-two patients (31%) were diagnosed with recurrence less than 1 year after curative resection for colorectal cancer (early recurrence) and 71 (69%) after more than 1 year (non-early recurrence).
  
  
  RESULTS
  The early recurrence group displayed a significantly lower overall survival rate for both colon cancer (p=0, 01) and rectal cancer (p<0.001). Inadequate lymph node dissection was a significant predictor for early relapse. There were no statistically significant differences in clinicopathological variables such as age, sex, primary tumor localization, stage, depth of invasion, lymphovascular invasion and perineural invasion between the early and non-early recurrence groups. However, a K-ras mutation subgroup was significantly associated with early recurrence (p<0.001).
  
  
  CONCLUSIONS
  Poor survival is associated with early recurrence for patients undergoing resection for non-metastatic colorectal cancer, as well as K-ras mutation.
authors.affiliation: Department of Medical Oncology, Erciyes University Faculty of Medicine, Kayseri, Turkey E-mail : bozkurt.oktay8@gmail.com.
authors.forename: Oktay
authors.initials: O
authors.lastname: Bozkurt
authors.forename: Mevlude
authors.initials: M
authors.lastname: Inanc
authors.forename: Esma
authors.initials: E
authors.lastname: Turkmen
authors.forename: Halit
authors.initials: H
authors.lastname: Karaca
authors.forename: Veli
authors.initials: V
authors.lastname: Berk
authors.forename: Ayse Ocak
authors.initials: AO
authors.lastname: Duran
authors.forename: Ersin
authors.initials: E
authors.lastname: Ozaslan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ucar
authors.forename: Ilhan
authors.initials: I
authors.lastname: Hacibekiroglu
authors.forename: Baki
authors.initials: B
authors.lastname: Eker
authors.forename: Osman
authors.initials: O
authors.lastname: Baspinar
authors.forename: Metin
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000235:genetics / Q000401:mortality / Q000601:surgery; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000601:surgery*; D005260:Female; D011905:Genes, ras; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects* / Q000592:standards; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors