title: [Role of redox- and hormonal metabolism in the mechanisms of skin aging].
abstract: The aim of the study was to investigate the role of redox balance in the pathogenesis of skin aging in menopausal women. 30 menopausal women aged 40 to 55 years and 30 reproductive women aged 25 to 35 years were studied. Qualitative assessment of the skin (moisture, fat, elasticity) was performed; in the venous blood hormonal metabolism indicators: estradiole - E, testosterone - T, follicle stimulating hormone - FSH and redox parameters - oxygen and lipid free radical content (EPR method), antioxidant enzymes (catalase, superoxide dismutase (SOD) and glutationreducrase (GR)) activity (spectroscopic method) were studied. According results of the study, in menopausal women statistically significant loss of skin elasticity and increase the number of pores was revealed in comparison to the reproductive women. These changes occur against the background of statistically significant increase of the blood testosterone and FSH content; estradiol in women menopausal period has tendency to decrease. Redox indicators of blood did not differ statistically significant in women of reproductive and menopausal period, although there was a tendency to increase the activity of catalase and GR in menopausal women period, indicating on the intensification of oxidative processes in this age group. Statistically significant negative correlation between blood estradiole content and SOD's activity (r=-0.413, p=0.0017) and positive correlation between blood estradiole content and GR activity (r=0.565, p=0.002) was revealed. Decrease in the estradiol concentration and disbalance in redox-system in the women's blood correlats with the rate of pigmented spots growth and decrease of the skin moisture. It is concluded that in mechanisms of skin aging of menopausal women estrogen-depending alterations in redox-balance places important role.
authors.affiliation: Tbilisi State Medical University, Department of Skin and Venereal Diseases, Tbilisi, Georgia.
authors.forename: K
authors.initials: K
authors.lastname: Berianidze
authors.affiliation: Tbilisi State Medical University, Department of Skin and Venereal Diseases, Tbilisi, Georgia.
authors.forename: A
authors.initials: A
authors.lastname: Katsitadze
authors.affiliation: Tbilisi State Medical University, Department of Skin and Venereal Diseases, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Jalaghania
authors.affiliation: Tbilisi State Medical University, Department of Skin and Venereal Diseases, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction; D015595:Skin Aging / Q000502:physiology*; D013482:Superoxide Dismutase / Q000097:blood; D013739:Testosterone / Q000097:blood
chemical_list: D000975:Antioxidants; D008055:Lipids; D013739:Testosterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D002374:Catalase; D013482:Superoxide Dismutase