title: Panobinostat: a review of trial results and future prospects in multiple myeloma.
abstract: Multiple myeloma is an incurable often devastating disease that is responsible for 1-2% of all cancers. Multiple myeloma is the second most common hematologic malignancy. Over the past two decades, advances in therapy have doubled life expectancy. Unfortunately, all patients ultimately relapse. Novel agents (immunomodulatory drugs and proteasome inhibitors) have changed the outlook for patients, but further breakthroughs are needed. Epigenetic treatments offer potential for advancing therapy by modifying oncogene responses. The acetylation status of various proteins can affect the availability of chromatin for transcription. This response may be modulated epigenetically to advantage using histone deacetylase inhibitors like panobinostat.
authors.affiliation: University of Washington School of Medicine - Medical Oncology, 825 Eastlake Ave E, Seattle, WA 98109, USA.
authors.forename: Edward N
authors.initials: EN
authors.lastname: Libby
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Becker
authors.forename: Nicholas
authors.initials: N
authors.lastname: Burwick
authors.forename: Damian J
authors.initials: DJ
authors.lastname: Green
authors.forename: Leona
authors.initials: L
authors.lastname: Holmberg
authors.forename: William Ira
authors.initials: WI
authors.lastname: Bensinger
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007211:Indoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D000077767:Panobinostat
chemical_list: D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D007211:Indoles; D000077767:Panobinostat
keywords: LBH589; epigenetics; histone deacetylase inhibitors; immunomodulatory drugs; multiple myeloma; panobinostat; proteasome inhibitors