title: Synthesis of polysubstituted cyclopenta[b]indoles via relay gold(I)/Brønsted acid catalysis.
abstract: An efficient relay catalytic process involving Au(i)/Brønsted acid to access various polysubstituted cyclopentannulated indoles from easily accessible 1-(2-aminophenyl)prop-2-ynols and readily available 1,3-dicarbonyls has been developed. In an unprecedented event, the intermediate 2-indolylmethyl cations undergo the cation-Ene reaction with various 1,3-dicarbonyls followed by an intramolecular Friedel-Crafts-type reaction generating functionalized cyclopenta[b]indoles.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Manuali PO, S. A. S. Nagar, Punjab 140306, India. ramsastry@iisermohali.ac.in.
authors.forename: Seema
authors.initials: S
authors.lastname: Dhiman
authors.forename: S S V
authors.initials: SS
authors.lastname: Ramasastry
mesh_terms: D000143:Acids / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*
chemical_list: D000143:Acids; D007211:Indoles; D006046:Gold