title: The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis.
abstract: R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related to R2TP suggests a linkage of its function with tumorigenesis. In this review, we provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kakihara
authors.forename: Makio
authors.initials: M
authors.lastname: Saeki
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D049109:Cell Proliferation; D004265:DNA Helicases / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D020718:Ribonucleoproteins, Small Nucleolar / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D018832:Molecular Chaperones; C555143:PIH1D1 protein, human; C472351:RPAP3 protein, human; D020718:Ribonucleoproteins, Small Nucleolar; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C486549:RUVBL1 protein, human; C122079:RUVBL2 protein, human