title: Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer.
abstract: OBJECTIVE
  To investigate a possible correlation between expression levels of heat shock protein 20 (HSP20) and tumor progression in patients with ovarian cancer.
  
  
  METHODS
  The study included 34 patients with ovarian cancer who were to undergo surgery, seven patients with ovarian carcinoid tumors, and five patients with normal ovaries as a control group. Ovarian tissues were obtained from patients by surgical resection and then analyzed by western blot.
  
  
  RESULTS
  Expression levels of HSP20 were inversely correlated with the grade of malignancy.
  
  
  CONCLUSIONS
  The present findings suggest that HSP20 may play a protective role against the progression of ovarian cancer. Thus, HSP20 may represent a new target for the prediction and treatment of ovarian cancer.
authors.forename: Naian
authors.initials: N
authors.lastname: Qiao
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Zhu
authors.forename: Haiying
authors.initials: H
authors.lastname: Li
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Qu
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D050886:HSP20 Heat-Shock Proteins / Q000032:analysis / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D050886:HSP20 Heat-Shock Proteins; C494382:HSPB6 protein, human