title: Association of rs6982567 near GDF6 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort.
abstract: BACKGROUND
  Growth differentiation factor 6 (GDF6) has been reported to be a novel disease gene for age-related macular degeneration (AMD) in Caucasians. This study aimed to investigate whether rs6982567 was associated with neovascular AMD (nAMD) or polypoidal choroidal vasculopathy (PCV) in a Han Chinese cohort.
  
  
  METHODS
  A total of 612 participants (251 PCV patients, 157 nAMD patients and 204 controls) were included in this study. The SNaPshot system was used to genotype the rs6982567. PLINK software was used to evaluate the genotypes and allele frequencies of patients and controls.
  
  
  RESULTS
  The allele frequencies of rs6982567 were not significantly associated with nAMD, PCV or PCV and nAMD combined. Subjects with the TT genotype had a 2.42-fold greater risk of PCV (95% confidence interval, 1.07-5.43, p = 0.0290) than subjects with CC genotype. A recessive model of rs6982567 was statistically significantly associated with PCV (odds ratio, 2.29; 95% confidence interval, 1.04-5.05; p = 0.0351). However, the association did not withstand stringent Bonferroni correction. There were no significant differences in genotype distributions or models in nAMD.
  
  
  CONCLUSIONS
  There was a possible weak association between the rs6982567 near GDF6 and PCV in this replication study with an independent Han Chinese cohort. A complete survey of the GDF6 locus with a larger sample size is needed in future studies.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Ji
authors.forename: Xiongze
authors.initials: X
authors.lastname: Zhang
authors.forename: Kunfang
authors.initials: K
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Su
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Chengguo
authors.initials: C
authors.lastname: Zuo
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou 510060, China. wenfeng208@foxmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Wen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005451:Fluorescein Angiography; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D055431:Growth Differentiation Factor 6 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011127:Polyps / Q000175:diagnosis / Q000235:genetics*; D057135:Wet Macular Degeneration / Q000175:diagnosis / Q000235:genetics*
chemical_list: C525906:GDF6 protein, human; D055431:Growth Differentiation Factor 6