title: Signaling pathways in mouse and human trophoblast differentiation: a comparative review.
abstract: The mouse is often used as a model for understanding human placentation and offers multiple advantages, including the ability to manipulate gene expression in specific compartments and to derive trophoblast stem cells, which can be maintained or differentiated in vitro. Nevertheless, there are numerous differences between the mouse and human placentas, only the least of which are structural. This review aims to compare mouse and human placentation, with a focus on signaling pathways involved in trophoblast lineage-specific differentiation.
authors.affiliation: Department of Pathology, Sanford Consortium for Regenerative Medicine, University of California San Diego, 9500 Gilman Drive, MC 0695, La Jolla, CA, 92093, USA, fsoncin@ucsd.edu.
authors.forename: Francesca
authors.initials: F
authors.lastname: Soncin
authors.forename: David
authors.initials: D
authors.lastname: Natale
authors.forename: Mana M
authors.initials: MM
authors.lastname: Parast
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010929:Placentation / Q000502:physiology*; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology*; D014327:Trophoblasts / Q000166:cytology*