title: Field-testing of the ICHD-3 beta/proposed ICD-11 diagnostic criteria for migraine with aura.
abstract: BACKGROUND
  In 2013 the International Headache Society published the third International Classification of Headache Disorders beta-version, ICHD-3 beta. Its structure is identical to that of the present proposed version of the International Classification of Diseases (ICD-11), although slightly abbreviated to fulfill the needs of ICD-11. In the following, only ICHD-3 beta is mentioned, but findings regarding the validity of ICHD-3 beta categories are equally relevant to the forthcoming ICD-11. Here we field-tested the criteria for 1.2 migraine with aura (MA), 1.2.1 migraine with typical aura (MTA), 1.2.3 hemiplegic migraine, 1.2.2 migraine with brainstem aura, and the alternative criteria A1.2 MA and A1.2.1 MTA.
  
  
  METHODS
  Clinical characteristics were systematically and prospectively collected from patients with 1.2.1 MTA, 1.2.4 familial hemiplegic migraine (FHM), 1.2.5 sporadic hemiplegic migraine (SHM) and 1.2.6 basilar-type migraine according to ICHD-2 in a cross-sectional study design. A database of 2464 patients with 1.1 migraine without aura and 1.2 migraine with non-hemiplegic aura and a database of 252 hemiplegic migraine patients (1.2.4 FHM or 1.2.5 SHM) was collected. We used SPSS 20 for Windows 8.0 for the statistical analysis.
  
  
  RESULTS
  All ICHD-2 patients fulfilled ICHD-3 beta criteria for 1.2 MA. The ICHD-3 beta criteria for 1.2.1 MTA were more sensitive than ICHD-2 and ICHD-3 beta alternative criteria; they resulted in fewer probable MA diagnoses. Too many patients fulfilled ICHD-2 and ICHD-3 beta criteria for 1.2.2 migraine with brainstem aura. ICHD-3 beta criteria for 1.2.4 FHM and 1.2.5 SHM both comply with ICHD-2.
  
  
  CONCLUSIONS
  The new criteria in ICHD-3 beta/proposed ICD-11 for 1.2 MA, 1.2.1 MTA, 1.2.3.1 FHM and 1.2.3.2 SHM have more desirable properties than ICHD-2 and the ICHD-3 beta alternative criteria. The criteria for 1.2.2 migraine with brainstem aura should be more restrictive.
authors.affiliation: The Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: Dana
authors.initials: D
authors.lastname: Li
authors.affiliation: The Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Christensen
authors.affiliation: The Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark jes.olesen@regionh.dk.
authors.forename: Jes
authors.initials: J
authors.lastname: Olesen
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008875:Middle Aged; D020325:Migraine with Aura / Q000145:classification* / Q000175:diagnosis*; D012680:Sensitivity and Specificity
keywords: Danish Headache Center; ICHD-3 beta; Migraine with aura; diagnostic criteria; field-test; primary migraine