title: Safety and Immunogenicity of purified chick embryo cell rabies vaccine (VaxiRab N) administered intradermally as post exposure prophylaxis.
abstract: The affordability to rabies vaccine for intramuscular administration in post exposure prophylaxis is a major constraint. Therefore, in countries, where there are financial constraints, World Health Organization recommends intradermal rabies vaccination that reduces the quantity and cost of vaccination. This study was done to evaluate the safety and immunogenicity of indigenously developed rabies vaccine (VaxiRab N) in comparison to a WHO recommended rabies vaccine (Rabipur) with demonstrated efficacy when administered by intradermal route using updated Thai Red Cross regimen. Eighty-six dog bite cases were randomly given either VaxiRab N (n = 43) or Rabipur (n = 43) as post exposure prophylaxis. The rabies virus neutralizing antibody concentrations on days 14, 28, 90, and 180 were tested by modified rapid fluorescent focus inhibition test. The geometric mean RVNA concentration of both the groups were compared using t- test and was found that, P value > 0.05 on all days, thus showing no significant difference between the 2 groups. The adverse drug events were also compared using Z-test and was found to be not statistically significant (Z = 1.476, P = 0.139). In conclusion, VaxiRab N was found to be safe and effective in post exposure prophylaxis by intradermal route and was similar to the WHO recommended rabies vaccine (Rabipur) of demonstrated efficacy.
authors.affiliation: a Department of Community Medicine; Kempegowda Institute of Medical Sciences (KIMS); Banashankari 2nd stage; Bangalore, India.
authors.forename: Hardanahalli S
authors.initials: HS
authors.lastname: Ravish
authors.forename: Veena
authors.initials: V
authors.lastname: Vijayashankar
authors.forename: Shampur N
authors.initials: SN
authors.lastname: Madhusudana
authors.forename: Mysore K
authors.initials: MK
authors.lastname: Sudarshan
authors.forename: Doddabele Ha
authors.initials: DH
authors.lastname: Narayana
authors.forename: Gangaboraiah
authors.initials: G
authors.lastname: Andanaiah
authors.forename: Belludi Y
authors.initials: BY
authors.lastname: Ashwin
authors.forename: Annadani R
authors.initials: AR
authors.lastname: Rachana
authors.forename: Manjula
authors.initials: M
authors.lastname: Shamanna
mesh_terms: D000328:Adult; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001733:Bites and Stings / Q000150:complications; D002642:Chick Embryo; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology* / Q000302:isolation & purification; D011820:Rabies virus / Q000276:immunology; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D011819:Rabies Vaccines
keywords: intradermal vaccination; post exposure rabies prophylaxis; purified chick embryo cell vaccine; rabies; rabies vaccines