title: Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice.
abstract: Mucositis is a common problem that results from cancer chemotherapy and is a cause of significant morbidity and occasional mortality. Its prevention and successful treatment can significantly enhance the quality of life of patients and improve their survival. Sea cucumber is a traditional aquatic food that has both nutritional and medicinal value. The polysaccharide fucoidan from the sea cucumber (SC-FUC) has various bioactivities. We examined the protective effect of different molecular weights (MWs 50 kDa-500 kDa) of fucoidan from the sea cucumber, Acaudina molpadioides, in a mouse model of cyclophosphamide (Cy)-induced intestinal mucositis. Results showed that the oral administration of SC-FUC markedly reversed Cy-induced damage in the mice. The sea cucumber fucoidan notably increased the ratio of the length of the intestinal villus to the crypt depth and ameliorated the IFN-γ/IL-4 ratio that signifies Th1/Th2 immune balance. Moreover, all the fucoidans in this study enhanced the expression of IgA by accelerating the expression of IL-6 that is probably combined with IL-10. The differing effects of the varied molecular weights of fucoidan may be due to the difference in the efficiency of absorption. This is a novel study on the potential preventive effects of SC-FUC on intestinal mucositis that may be related to the efficiency of its absorption during digestion. Sea cucumber fucoidan (SC-FUC) may be used as a potential food supplement to prevent chemotherapeutic mucositis.
authors.affiliation: College of Food Science and Engineering, Ocean University of China, Yushan Road 5th, Qingdao, Shandong Province 266003, China. tangqingjuan@ouc.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Zuo
authors.forename: Xuemin
authors.initials: X
authors.lastname: Li
authors.forename: Yaoguang
authors.initials: Y
authors.lastname: Chang
authors.forename: Gaofei
authors.initials: G
authors.lastname: Duan
authors.forename: Long
authors.initials: L
authors.lastname: Yu
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
authors.forename: Qingjuan
authors.initials: Q
authors.lastname: Tang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D005643:Fucose / Q000097:blood; D005786:Gene Expression Regulation; D007070:Immunoglobulin A / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D052016:Mucositis / Q000139:chemically induced / Q000517:prevention & control*; D011134:Polysaccharides / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000378:metabolism; D012616:Sea Cucumbers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007070:Immunoglobulin A; D015850:Interleukin-6; D011134:Polysaccharides; D012333:RNA, Messenger; D016753:Interleukin-10; D015847:Interleukin-4; D005643:Fucose; D007371:Interferon-gamma; D003520:Cyclophosphamide; C007789:fucoidan