title: Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: effects on early folliculogenesis.
abstract: The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: J M
authors.initials: JM
authors.lastname: Gámez
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Penalba
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: Cardoso
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina; Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica, Católica, Argentina.
authors.forename: P Scacchi
authors.initials: PS
authors.lastname: Bernasconi
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Carbone
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: O
authors.initials: O
authors.lastname: Ponzo
authors.affiliation: Laboratory of Neuroendocrinology and Behavior, Department of Biodiversity and Experimental Biology, Faculty of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Pandolfi
authors.affiliation: Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica, Católica, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Scacchi
authors.affiliation: Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina; Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica, Católica, Argentina. Electronic address: rreynoso@fmed.uba.ar.
authors.forename: R
authors.initials: R
authors.lastname: Reynoso
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000187:drug effects* / Q000473:pathology; D010636:Phenols / Q000633:toxicity*; D010902:Pituitary Gland / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D012741:Sexual Maturation; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D007986:Luteinizing Hormone; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Estradiol; FSH; Folliculogenesis; LH; Prepubertal rats