title: [The experimental evaluation of antiradiation effectiveness of genistein by survival rates and bone marrow hemopoiesis of mice irradiated by X-rays].
abstract: The study was aimed at evaluating the radioprotective effectiveness of genistein administered at different times before or after acute irradiation. Evaluation ofradioprotective efficiency was performed by studying the 30-day survival rate, life expectancy, bone marrow hemapoiesis using the method of endogenous and exogenous colony formation. We have established that genistein at a dose of 200 mg/kg when administered 1 hour prior to irradiation has the highest radioprotective efficiency. In this case, genistein protects mice against death due to X-ray radiation at doses LD(50-90/30), increasing their survival rate by 30-44%, and reduces expression of post radiation disorders of bone marrow hematopoiesis.
authors.forename: A N
authors.initials: AN
authors.lastname: Grebeniuk
authors.forename: V A
authors.initials: VA
authors.lastname: Basharin
authors.forename: R A
authors.initials: RA
authors.lastname: Tarumov
authors.forename: N V
authors.initials: NV
authors.lastname: Aksenova
authors.forename: V B
authors.initials: VB
authors.lastname: Nazarov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kovtun
authors.forename: I E
authors.initials: IE
authors.lastname: Chekunov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects; D019833:Genistein / Q000008:administration & dosage*; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D011832:Radiation Injuries / Q000188:drug therapy / Q000473:pathology; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D014916:Whole-Body Irradiation; D014965:X-Rays
chemical_list: D011837:Radiation-Protective Agents; D019833:Genistein