title: Synthesis, structure, and antiproliferative activity of ruthenium(II) arene complexes with N,O-chelating pyrazolone-based β-ketoamine ligands.
abstract: Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.
authors.affiliation: School of Pharmacy and ‡School of Science and Technology, University of Camerino , via S. Agostino 1, 62032 Camerino, Macerata, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pettinari
authors.forename: Fabio
authors.initials: F
authors.lastname: Marchetti
authors.forename: Claudio
authors.initials: C
authors.lastname: Pettinari
authors.forename: Agnese
authors.initials: A
authors.lastname: Petrini
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Clavel
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D000586:Amination; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008958:Models, Molecular; D010051:Ovarian Neoplasms / Q000188:drug therapy; D047069:Pyrazolones / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D002614:Chelating Agents; D056831:Coordination Complexes; D047069:Pyrazolones; D012428:Ruthenium