title: Investigation of mtDNA control region sequences in a Tibetan population sample from China.
abstract: Mitochondrial hypervariable region sequences including HVI and HVII (15,751-520) were investigated from 174 unrelated Tibetan individuals living in Tibet Autonomous Region in People's Republic of China. The resulted sequences were aligned and compared with revised Cambridge sequence (rCRS). This sequence variability rendered a high gene diversity value (0.9940 ± 0.0021) and a high random match probability (0.0118) was determined with PIC of 0.9882. Among a total of 174 samples, 217 polymorphic sites were identified, which defined 135 haplotypes. A total of 135 different haplotypes were detected, 113 of them were unique and 22 were shared. The most common haplogroup was M9a1a1c1b1 (16.09%), followed by A11 (6.32%), A (5.17%), R (4.60%), A15 (4.60%), and G3a1 (3.45). The proportions of macro-haplogroups M, N, and L were 54.60%, 42.53%, and 2.87%, respectively. By principal component analysis (PCA), there was no special cluster between Tibetans and other populations except that the structure of Tibetans closely resembled that of Uygur in component 2.
authors.affiliation: a Rehabilitation Medical Center, Shengjing Hospital Affiliated to China Medical University , Shenyang , China and.
authors.forename: Yun-Ke
authors.initials: YK
authors.lastname: Wang
authors.affiliation: b School of Forensic Medicine, China Medical University , Shenyang , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.affiliation: a Rehabilitation Medical Center, Shengjing Hospital Affiliated to China Medical University , Shenyang , China and.
authors.forename: Xuan
authors.initials: X
authors.lastname: Han
authors.affiliation: b School of Forensic Medicine, China Medical University , Shenyang , China.
authors.forename: Mei
authors.initials: M
authors.lastname: Ding
authors.affiliation: b School of Forensic Medicine, China Medical University , Shenyang , China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.affiliation: b School of Forensic Medicine, China Medical University , Shenyang , China.
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Wang
authors.affiliation: a Rehabilitation Medical Center, Shengjing Hospital Affiliated to China Medical University , Shenyang , China and.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism; D011110:Polymorphism, Genetic; D025341:Principal Component Analysis; D017422:Sequence Analysis, DNA; D018609:Tibet
chemical_list: D004272:DNA, Mitochondrial; D004247:DNA
keywords: Haplogroup; hypervariable region; mitochondrial DNA; tibetan