title: Higher 17α-hydroxyprogesterone levels aggravated the severity of male adolescent acne in Northeast China.
abstract: BACKGROUND
  The relationship between serum hormone levels and adolescent acne is not fully clarified.
  
  
  OBJECTIVE
  To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China.
  
  
  METHODS
  A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0.
  
  
  RESULTS
  Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females.
  
  
  CONCLUSIONS
  Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.
authors.affiliation: Department of Dermatology, 1st Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wei
authors.forename: Le
authors.initials: L
authors.lastname: Qu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Ting
authors.initials: T
authors.lastname: Xiao
authors.forename: Hua-Chen
authors.initials: HC
authors.lastname: Wei
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
authors.forename: Chundi
authors.initials: C
authors.lastname: He
mesh_terms: D000152:Acne Vulgaris / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000735:Androstenedione / Q000097:blood*; D016022:Case-Control Studies; D002681:China; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011374:Progesterone / Q000031:analogs & derivatives* / Q000097:blood; D012307:Risk Factors; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: C002175:progesterone 17 alpha-hydroperoxide; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate