title: A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2.
abstract: The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. fanjl@dlut.edu.cn.
authors.forename: Benhua
authors.initials: B
authors.lastname: Wang
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Xianwu
authors.initials: X
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
authors.forename: Jingyun
authors.initials: J
authors.lastname: Wang
authors.forename: Huiying
authors.initials: H
authors.lastname: Mu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D051546:Cyclooxygenase 2 / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D057054:Molecular Imaging; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D061848:Optical Imaging; D010078:Oxazines / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D010078:Oxazines; C008619:Nile Blue; D051546:Cyclooxygenase 2