title: High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin.
abstract: Loss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum-infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria (P = .011) and with malaria-related mortality (P = .0003). Measuring sEPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria.
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT Université Pierre et Marie Curie, Paris, France.
authors.forename: Azizath
authors.initials: A
authors.lastname: Moussiliou
authors.affiliation: Département de pédiatrie, Hôpital Mère-enfant de la lagune.
authors.forename: Maroufou J
authors.initials: MJ
authors.lastname: Alao
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT.
authors.forename: Lise
authors.initials: L
authors.lastname: Denoeud-Ndam
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT.
authors.forename: Rachida
authors.initials: R
authors.lastname: Tahar
authors.affiliation: Centre d'Etude et de Recherche sur le paludisme associé à la Grossesse et à l'Enfance, Université d'Abomey-Calavi.
authors.forename: Sem
authors.initials: S
authors.lastname: Ezimegnon
authors.affiliation: Service de pédiatrie, Centre National Hospitalo-Universitaire.
authors.forename: Gratien
authors.initials: G
authors.lastname: Sagbo
authors.affiliation: Service de pédiatrie, Hôpital de zone de Suru-Léré, Cotonou, Bénin.
authors.forename: Annick
authors.initials: A
authors.lastname: Amoussou
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT.
authors.forename: Adrian J F
authors.initials: AJ
authors.lastname: Luty
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT.
authors.forename: Philippe
authors.initials: P
authors.lastname: Deloron
authors.affiliation: PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes Institut de Recherche pour le Développement, UMR216-MERIT.
authors.forename: Nicaise
authors.initials: N
authors.lastname: Tuikue Ndam
mesh_terms: D015703:Antigens, CD / Q000097:blood* / Q000378:metabolism; D000962:Antimalarials / Q000627:therapeutic use; D001541:Benin / Q000453:epidemiology; D002675:Child, Preschool; D000074283:Endothelial Protein C Receptor; D005838:Genotype; D006801:Humans; D016779:Malaria, Cerebral / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality*; D011803:Quinine / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000097:blood* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D000962:Antimalarials; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface; D011803:Quinine
keywords: EPCR; cerebral malaria; plasmodium; protein C; sEPCR