title: Efficacy of intra-cervical misoprostol in the management of early pregnancy failure.
abstract: The aim of this prospective study was to assess the efficacy of intra-cervical misoprostol in the management of early pregnancy failure. Twenty women with early pregnancy failure received intra-cervical misoprostol via an endometrial sampling cannula. The first dose was 50 μg of misoprostol dissolved in 5 ml of normal saline. The administration was repeated after 12 h if there was no vaginal bleeding or pain. Nine (45%) women received 1 dose and 11 (55%) women received 2 doses of intra-cervical misoprostol. Abortion within 24 h occurred in 16 (80%) women, and complete abortion was achieved in 14 (70%) cases. Two women with incomplete abortion were managed with 600 μg of misoprostol orally (1 case) and surgical intervention (1 case). The mean time interval between the first dose and the abortion was 10.6 ± 6.3 h. Two women did not respond within 24 h of treatment initiation, 1 woman withdrew consent after the first treatment, and 1 woman developed heavy vaginal bleeding after the first dose and underwent surgical management. Intra-cervical misoprostol is a promising method of medical treatment of early pregnancy failure. Further randomized clinical trials are needed to validate its safety and efficacy.
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Abdulrahim A
authors.initials: AA
authors.lastname: Rouzi
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Nisma
authors.initials: N
authors.lastname: Almansouri
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Nora
authors.initials: N
authors.lastname: Sahly
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Nawal
authors.initials: N
authors.lastname: Alsenani
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Hussam
authors.initials: H
authors.lastname: Abed
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Darhouse
authors.affiliation: Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Nabil
authors.initials: N
authors.lastname: Bondagji
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000022:Abortion, Spontaneous / Q000188:drug therapy*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000209:etiology
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol