title: Antimetastatic and anti-inflammatory potentials of essential oil from edible Ocimum sanctum leaves.
abstract: Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Thamilvaani
authors.identifier: 0000-0001-5382-0799
authors.initials: T
authors.lastname: Manaharan
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, India.
authors.forename: Ramaraj
authors.initials: R
authors.lastname: Thirugnanasampandan
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Rajarajeswaran
authors.initials: R
authors.lastname: Jayakumar
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, India.
authors.forename: Gunasekar
authors.initials: G
authors.lastname: Ramya
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, India.
authors.forename: Gogul
authors.initials: G
authors.lastname: Ramnath
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: M S
authors.identifier: 0000-0002-3404-3178
authors.initials: MS
authors.lastname: Kanthimathi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D031339:Ocimum; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D020780:Matrix Metalloproteinase 9