title: CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel.
abstract: A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokuda
authors.affiliation: TERUMO Co., R&D Headquarters, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Uejima
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Masuda
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kawamura
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Yasumi
authors.initials: Y
authors.lastname: Ohta
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Motoyama
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Noda
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Sasagawa
authors.affiliation: Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Teru
authors.initials: T
authors.lastname: Okitsu
authors.affiliation: Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takeuchi
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ohta
keywords: (000.0000) General; (000.2700) General science