title: The biological effects of hsa-miR-1908 in human adipocytes.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. MiR-1908 is a recently identified miRNA that is highly expressed in human adipocytes. However, it is not known what role of miR-1908 is involved in the regulation of human adipocytes. In this study, we demonstrate that the level of miR-1908 increases during the adipogenesis of human multipotent adipose-derived stem (hMADS) cells and human preadipocytes-visceral. Overexpression of miR-1908 in hMADS cells inhibited adipogenic differentiation and increased cell proliferation, suggesting that miR-1908 is involved in the regulation of adipocyte cell differentiation and metabolism, and, thus, may have an effect on human obesity.
authors.affiliation: Institute of Pediatrics, Nanjing Medical University, No. 140 Hanzhong Road, Nanjing, 210029, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Shi
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Ling-xia
authors.initials: LX
authors.lastname: Pang
authors.forename: Guang-feng
authors.initials: GF
authors.lastname: Xu
authors.forename: Nan
authors.initials: N
authors.lastname: Gu
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhu
authors.forename: Xi-rong
authors.initials: XR
authors.lastname: Guo
authors.forename: Yu-hui
authors.initials: YH
authors.lastname: Ni
authors.forename: Chen-bo
authors.initials: CB
authors.lastname: Ji
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D050156:Adipogenesis / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*
chemical_list: C577645:MIRN1908 microRNA, human; D035683:MicroRNAs