title: The roles of protein expression in synaptic plasticity and memory consolidation.
abstract: The amount and availability of proteins are regulated by their synthesis, degradation, and transport. These processes can specifically, locally, and temporally regulate a protein or a population of proteins, thus affecting numerous biological processes in health and disease states. Accordingly, malfunction in the processes of protein turnover and localization underlies different neuronal diseases. However, as early as a century ago, it was recognized that there is a specific need for normal macromolecular synthesis in a specific fragment of the learning process, memory consolidation, which takes place minutes to hours following acquisition. Memory consolidation is the process by which fragile short-term memory is converted into stable long-term memory. It is accepted today that synaptic plasticity is a cellular mechanism of learning and memory processes. Interestingly, similar molecular mechanisms subserve both memory and synaptic plasticity consolidation. In this review, we survey the current view on the connection between memory consolidation processes and proteostasis, i.e., maintaining the protein contents at the neuron and the synapse. In addition, we describe the technical obstacles and possible new methods to determine neuronal proteostasis of synaptic function and better explain the process of memory and synaptic plasticity consolidation.
authors.affiliation: Sagol Department of Neurobiology, University of Haifa Haifa, Israel.
authors.forename: Tali
authors.initials: T
authors.lastname: Rosenberg
authors.affiliation: Sagol Department of Neurobiology, University of Haifa Haifa, Israel.
authors.forename: Shunit
authors.initials: S
authors.lastname: Gal-Ben-Ari
authors.affiliation: Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany ; Research Group Neuralomics, Leibniz Institute for Neurobiology Magdeburg, Germany ; Center for Behavioral Brain Sciences Magdeburg, Germany.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Dieterich
authors.affiliation: Research Group Neuroplasticity, Leibniz Institute for Neurobiology Magdeburg, Germany.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kreutz
authors.affiliation: Network Biology Research Laboratories and Faculty of Medicine, Technion - Israel Institute of Technology Haifa, Israel.
authors.forename: Noam E
authors.initials: NE
authors.lastname: Ziv
authors.affiliation: Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany ; Center for Behavioral Brain Sciences Magdeburg, Germany ; Medical School, Otto von Guericke University Magdeburg, Germany.
authors.forename: Eckart D
authors.initials: ED
authors.lastname: Gundelfinger
authors.affiliation: Sagol Department of Neurobiology, University of Haifa Haifa, Israel ; Center for Gene Manipulation in the Brain, University of Haifa Haifa, Israel.
authors.forename: Kobi
authors.initials: K
authors.lastname: Rosenblum
keywords: learning; memory consolidation; protein expression; synapse; synaptic stability; translation regulation