title: Heat shock protein 70 in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease that caused dementia which has no effective treatment. Growing evidence has demonstrated that AD is a "protein misfolding disorder" that exhibits common features of misfolded, aggregation-prone proteins and selective cell loss in the mature nervous system. Heat shock protein 70 (HSP70) attracts extensive attention worldwide, because it plays a crucial role in preventing protein misfolding and inhibiting aggregation and represents a class of proteins potentially involved in AD pathogenesis. Numerous studies have indicated that HSP70 could suppress the progression of AD with in vitro and in vivo experiments. Thus, targeting HSP70 and the related compounds might represent a promising strategy for the treatment of AD.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China.
authors.forename: Rui-Chun
authors.initials: RC
authors.lastname: Lu
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China.
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.affiliation: Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
authors.forename: An-Mu
authors.initials: AM
authors.lastname: Xie
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China ; Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China.
authors.forename: Jin-Tai
authors.identifier: 0000-0002-7686-0547
authors.initials: JT
authors.lastname: Yu
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China ; Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China.
authors.forename: Lan
authors.identifier: 0000-0002-8759-7588
authors.initials: L
authors.lastname: Tan
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D057165:Proteostasis Deficiencies / Q000235:genetics* / Q000473:pathology
chemical_list: D018840:HSP70 Heat-Shock Proteins