title: Mass spectrometry for the detection of potential psychiatric biomarkers.
abstract: The search for molecules that can act as potential biomarkers is increasing in the scientific community, including in the field of psychiatry. The field of proteomics is evolving and its indispensability for identifying biomarkers is clear. Among proteomic tools, mass spectrometry is the core technique for qualitative and quantitative identification of protein markers. While significant progress has been made in the understanding of biomarkers for neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis and Parkinson's disease, psychiatric disorders have not been as extensively investigated. Recent and successful applications of mass spectrometry-based proteomics in fields such as cardiovascular disease, cancer, infectious diseases and neurodegenerative disorders suggest a similar path for psychiatric disorders. In this brief review, we describe mass spectrometry and its use in psychiatric biomarker research and highlight some of the possible challenges of undertaking this type of work. Further, specific examples of candidate biomarkers are highlighted. A short comparison of proteomic with genomic methods for biomarker discovery research is presented. In summary, mass spectrometry-based techniques may greatly facilitate ongoing efforts to understand molecular mechanisms of psychiatric disorders.
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA.
authors.forename: Armand G
authors.initials: AG
authors.lastname: Ngounou Wetie
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA.
authors.forename: Izabela
authors.initials: I
authors.lastname: Sokolowska
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Wormwood
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Beglinger
authors.affiliation: Department of Psychiatry, University of Rostock, Rostock, Gehlsheimer Straße 20, D-18147 Germany.
authors.forename: Tanja Maria
authors.initials: TM
authors.lastname: Michel
authors.affiliation: Department of Psychiatry, University of Rostock, Rostock, Gehlsheimer Straße 20, D-18147 Germany ; College of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP UK.
authors.forename: Johannes
authors.initials: J
authors.lastname: Thome
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA.
authors.forename: Costel C
authors.initials: CC
authors.lastname: Darie
authors.affiliation: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810 USA ; Neuropsychology Clinic and Psychoeducation Services, SUNY Plattsburgh, 101 Broad St, Plattsburgh, 12901 NY USA.
authors.forename: Alisa G
authors.initials: AG
authors.lastname: Woods
keywords: Biomarker; Mass spectrometry; Proteomics; Psychiatry