title: [Clinical study on chemotherapy of lobaplatin combined with docetaxel in patients with relapsed ovarian cancer].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of lobaplatin combined with docetaxel in the treatment of the recurrent ovarian carcinoma.
  
  
  METHODS
  We collected 31 patients who diagnosed as recurrent ovarian carcinoma according to the histopathology or cytology from Tumor Hospital of Hunan Province from January 2011 to January 2013. The patients received cisplatin-based chemotherapy or carboplatin-based chemotherapy before the combined chemotherapy of docetaxel and lobaplatin. For patients with the recurrence, they received a treatment at a dose of 80 mg/m2 for docetaxel on day 1 and a dose of 30 mg/m2 for lobaplatin on day 2, which lasted for 21 days as a treatment cycle. Th e patients received 6-cycle treatment at most.
  
  
  RESULTS
  A total of 153 cycles of chemotherapy were given to 31 patients, with a median of 4 (2-6) cycles. Three patients showed complete response, 11 partial response, 2 stable disease, and 15 progressive disease. The objective response rate (ORR) was 45.16% (95% CI, 26.61%-63.72%), and the disease control rate (DCR) was 51.63% (95% CI, 32.98%-70.25%). The median progression free survival was 7 months (95% CI, 4.27-9.73 months). For the toxic and side effects among the 31 patients, the numbers of the grade 3, grade 2, and grade 1 leukopenia were 1, 8, and 13, respectively. Meanwhile, 18 were grade 1-2 neutropenia, 17 grade 1-2 anemia, and 2 grade 1 thrombocytopenia. At the same time, alimentary canal reaction followed by nausea and vomiting was relatively modest and could be controlled. The serious damage of hepatic-renal function was not found.
  
  
  CONCLUSIONS
  The chemotherapy of lobaplatin combined with docetaxel is effective on recurrent and refractory ovarian cancer with low side effects, which has advantages over the second-line chemotherapy protocols.
authors.affiliation: Th ird Division of Department of Gynecological Oncology, Affi liated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410006, China 18073181648@163.com.
authors.forename: Xinchun
authors.initials: X
authors.lastname: Li
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Li
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin; D000077216:Carcinoma, Ovarian Epithelial; D002945:Cisplatin; D003503:Cyclobutanes / Q000627:therapeutic use*; D018572:Disease-Free Survival; D000077143:Docetaxel; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D003503:Cyclobutanes; D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; C066228:lobaplatin; D002945:Cisplatin