title: Cytotoxic agents for KB and SiHa cells from n-hexane fraction of Cissampelos pareira and its chemical composition.
abstract: Eleven constituents were characterised by gas chromatography-mass spectrometry analysis, and five molecules were isolated using column chromatography. The in vitro study of the extract and isolated molecules against KB and SiHa cell lines revealed oleanolic acid (1) and oleic acid (2) as potent cytotoxic molecules with potential anticancer activity. The IC50 values of n-hexane extract (CPHF), oleanolic acid (1) and oleic acid (2) were >300, 56.08 and 70.7 μg/mL (μM), respectively, against KB cell lines and >300, 47.24 and 80.2 μg/mL (μM), respectively, against SiHa cell lines.
authors.affiliation: a Academy of Scientific & Innovative Research , New Delhi , India.
authors.forename: Manju
authors.initials: M
authors.lastname: Bala
authors.forename: Kunal
authors.initials: K
authors.lastname: Pratap
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Verma
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Padwad
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D045744:Cell Line, Tumor; D031606:Cissampelos / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D019301:Oleic Acid; D009828:Oleanolic Acid
keywords: Cissampelos pareira; anti-cancer activity; n-hexane fraction