title: Frailty and cognitive decline: how do they relate?
abstract: OBJECTIVE
  To provide a comprehensive review of the recent literature (published over the last 12 months) exploring the relationship between frailty and cognition.
  
  
  RESULTS
  Fourteen studies were retained for the present review. No randomized controlled trial was found. Overall, the main findings of the selected studies appeared to be mainly confirmatory of the previous evidence. In longitudinal studies, physical frailty was found to predict the incidence of cognitive impairment and dementia. Cross-sectional studies showed that frail individuals have lower cognitive performance compared with nonfrail persons. Interestingly, few studies examined the association between frailty and specific cognitive functions and domains, reporting a significant impairment of attention and executive functions. Finally, we found several studies including cognitive measures in the operational definitions of frailty.
  
  
  CONCLUSIONS
  The present findings are suggestive of an almost complete lack of evidence on the addressed topic. In particular, randomized controlled trials are strongly needed in order to gain insights about the possibility of positively affecting the frailty syndrome by acting of cognition and improving cognitive impairment by targeting the physical components of frailty. Moreover, these studies may produce the first evidences about the novel concept of 'cognitive frailty' and its potential for reversibility.
authors.affiliation: aDepartment of Neurology and Psychiatry, Memory Clinic, 'Sapienza' University, Rome, Italy bGérontopôle, Centre Hospitalier Universitaire de Toulouse cInserm UMR1027 dUniversité de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Marco
authors.initials: M
authors.lastname: Canevelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.forename: Gabor Abellan
authors.initials: GA
authors.lastname: van Kan
mesh_terms: D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000209:etiology / Q000517:prevention & control; D001288:Attention; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control; D056344:Executive Function; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans