title: A Case of Severe Carotid Stenosis in a Patient with Familial Hypercholesterolemia without Significant Coronary Artery Disease.
abstract: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by elevated low-density lipoprotein cholesterol levels in the blood. In its heterozygous form, it occurs in 1 in 500 individuals in the general population. It is an important contributor to the early onset of coronary artery disease (CAD), accounting for 5-10% of cases of cardiovascular events in people younger than 50 years. Atherogenesis triggered by hypercholesterolemia generally progresses faster in the coronary arteries, followed by the subsequent involvement of other arteries such as the carotids. Thus, symptoms of CAD commonly appear before the onset of significant carotid stenosis. Herein, we report the case of a patient with untreated FH who had severe carotid atherosclerosis at the age of 46 years but had no evidence of significant CAD.
authors.affiliation: Marcor Clinic, Maximum Body Care and Recovery, Avenida Presidente Vargas 811, 64200-200 Parnaíba, PI, Brazil.
authors.forename: Marcos Aurélio Lima
authors.initials: MA
authors.lastname: Barros
authors.affiliation: Genetics and Molecular Biology Laboratory, Federal University of Piauí, Avenida São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil.
authors.forename: Hygor
authors.initials: H
authors.lastname: Ferreira-Fernandes
authors.affiliation: Faculty of Medicine, Federal University of Piauí, Avenida São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil.
authors.forename: Ingrid Cristina Rêgo
authors.initials: IC
authors.lastname: Barros
authors.affiliation: Faculty of Medicine, Federal University of Piauí, R. Doutor Natan Portela Nunes s/n, 64049-550 Teresina, PI, Brazil.
authors.forename: Adriel Rêgo
authors.initials: AR
authors.lastname: Barbosa
authors.affiliation: Genetics and Molecular Biology Laboratory, Federal University of Piauí, Avenida São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil.
authors.forename: Giovanny Rebouças
authors.initials: GR
authors.lastname: Pinto