title: Molecular events in gastric carcinogenesis.
abstract: Gastric cancer represents an important problem for the public health, being one of the main causes of mortality. At present, it represents the second cause of mortality due to cancer, after the bronchopulmonary cancer in men and the fourth cause of mortality in women. Important progresses have been made in the last couple of years in determining the neoplastic etiopathogenesis, but it cannot be affirmed that the genetic mutations chain, which leads to the appearance of the malignant cell, has been fully understood.
authors.affiliation: "Prof. Dr. D. Gerota" Ministry of Internal Affairs Emergency Hospital, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Mahu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: A P
authors.initials: AP
authors.lastname: Purcarea
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: C M
authors.initials: CM
authors.lastname: Gheorghe
authors.affiliation: "Dr. Carol Davila" Clinical Nephrology Hospital, Bucharest, Romania.
authors.forename: M R
authors.initials: MR
authors.lastname: Purcarea
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D051177:Catenins / Q000378:metabolism; D049109:Cell Proliferation / Q000235:genetics*; D016213:Cyclins / Q000378:metabolism; D005260:Female; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics*; D013274:Stomach Neoplasms / Q000145:classification / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D016212:Transforming Growth Factor beta / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D051177:Catenins; D016213:Cyclins; D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53
keywords: gastric carcinogenesis; molecular events