title: Overexpression of phospholipase A2 Group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression.
abstract: BACKGROUND
  Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide.
  
  
  METHODS
  Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high- risk population in China.
  
  
  RESULTS
  Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04).
  
  
  CONCLUSIONS
  Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China E-mail : liufen05@ccmu.edu.cn, wei6014@yahoo.com.
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Zhai
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Xin-Qing
authors.initials: XQ
authors.lastname: Li
authors.forename: Robert T
authors.initials: RT
authors.lastname: Cormier
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D054501:Group II Phospholipases A2 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D051546:Cyclooxygenase 2; D054501:Group II Phospholipases A2; C516287:PLA2G2A protein, human