title: Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity.
abstract: Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea.
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jang Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Xi Tao
authors.initials: XT
authors.lastname: Yan
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Yang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D007700:Kinetics; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013267:Stilbenes; D004851:Epoxide Hydrolases