title: [Association of vitamin D receptor Fok I and Bsm I polymorphisms with dyslipidemias in elderly male patients with type 2 diabetes].
abstract: OBJECTIVE
  To assess the association of vitamin D receptor (VDR) gene Fok I and Bsm I polymorphisms with dyslipidemia in elderly male patients with type 2 diabetes of Han nationality.
  
  
  METHODS
  A total of 328 elderly male residents of Han nationality in Beijing, including 237 type 2 diabetic patients and 91 healthy control subjects, were enrolled in this study. The diabetic patients were divided into non-dyslipidemia group (DO group, n=134) and dyslipidemia group (DH group, n=103). All the participants were genotyped for Fok I and Bsm I polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing technology, and the results were compared with their clinical characteristics.
  
  
  RESULTS
  For Fok I, the frequency of F allele was significantly higher in the diabetic patients than in the control group (Χ(2)=3.873, P=0.049, OR=1.439, 95% CI: 1.001-2.071). In the dominant model, the frequency of FF genotype was significantly higher in the diabetic group (Χ(2)=5.057, P=0.025, OR=1.756, 95% CI: 1.072-2.875) as well as in DH group (Χ(2)=6.168, P=0.013, OR=2.06, 95% CI: 1.161-3.663) than in the control group. There was no significant differences in the genotype frequency or allele distribution in other paired groups (P>0.05). Compared with Ff + ff genotype, FF genotype was associated with a significantly decreased average diastolic blood pressure (P=0.039) but significantly increased postprandial blood glucose (P=0.035), triglycerides (P=0.049) and uric acid (P=0.031). No significant difference was detected in genotype frequency or allele distribution of Bsm I polymorphisms between the groups (P>0.05); serum creatinine levels were significantly higher in bb genotype than in BB + Bb genotype group (P=0.011).
  
  
  CONCLUSIONS
  VDR gene Fok I polymorphisms may be a risk factor for dyslipidemia in elderly male patients with type 2 diabetes among Chinese Han population, where Bsm I polymorphisms are not associated with diabetic dyslipdiemia.
authors.affiliation: Institute of Geriatrics/Key Laboratory of Normal Aging and Geriatrics, General Hospital of PLA/Chinese PLA Medical School, Beijing 100853, China. E-mail: 286162039@qq.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xia
authors.forename: Yazhuo
authors.initials: Y
authors.lastname: Hu
authors.forename: Honghong
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Shuhong
authors.initials: S
authors.lastname: Fu
authors.forename: Xinli
authors.initials: X
authors.lastname: Deng
authors.forename: Yao
authors.initials: Y
authors.lastname: He
mesh_terms: D000368:Aged; D000483:Alleles; D001786:Blood Glucose; D001794:Blood Pressure; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D050171:Dyslipidemias / Q000235:genetics*; D005006:Ethnicity; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D018167:Receptors, Calcitriol; D014280:Triglycerides