title: Effect of angiogenesis inhibitor SU6668 in combination with 5-Fu on liver metastasis from transplantation tumors of human colorectal cancer in nude mice.
abstract: This study was to investigate inhibiting effect of angiogenesis inhibitor SU6668 in combination with 5-Fu on liver metastasis from human colon cancer. Results showed that metastasis rates in SU6668+5-Fu group, SU6668 group, 5-Fu group decreased obviously (P<0.01). Compared with 5-Fu group and control group, microvessel density significantly decreased in SU6668+5-Fu group and SU6668 group (P<0.05). Vascular endothelial growth factor and base fibroblast growth factor reduced obviously in SU6668+5-Fu group, SU6668 group and 5-Fu group compared with control group, and there were significant differences among SU6668+5-Fu group, SU6668 group and 5-Fu group (P<0.05). Thus, SU6668 can inhibit liver metastasis from colorectal cancer through anti-angiogenesis, and it would have a synergistic effect in combination with 5-Fu. Therefore, SU6668 combined with 5-Fu could be considered as a safe and effective antitumor strategy.
authors.affiliation: Department of General Surgery, The Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of General Surgery, The Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Yinlu
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of General Surgery, The Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors.forename: Zhanyuan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors.forename: Zhaoting
authors.initials: Z
authors.lastname: Li
keywords: 5-Fu; Neovascularization; colon neoplasm; inbred BALB C; liver metastasis; mice; pathologic