title: What are our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research.
abstract: BACKGROUND
  Ancestry estimation serves as a tool to identify genetic contributions to disease but may contribute to racial discrimination and stigmatization. We sought to understand user perspectives on the benefits and harms of ancestry estimation to inform research practice and contribute to debates about the use of race and ancestry in genetics.
  
  
  METHODS
  Key informant interviews with 22 scientists were conducted to examine scientists' understandings of the benefits and harms of ancestry estimation.
  
  
  RESULTS
  Three main perspectives were observed among key informant scientists who use ancestry estimation in genetic epidemiology research. Population geneticists self identified as educators who controlled the meaning and application of ancestry estimation in research. Clinician-researchers were optimistic about the application of ancestry estimation to individualized risk assessment and personalized medicine. Epidemiologists remained ambivalent toward ancestry estimation and suggested a continued role for race in their research.
  
  
  CONCLUSIONS
  We observed an imbalance of control over the meaning and application of ancestry estimation among disciplines that may result in unwarranted or premature translation of ancestry estimation into medicine and public health. Differences in disciplinary perspectives need to be addressed if translational benefits of genetic ancestry estimation are to be realized.
authors.affiliation: Senior Fellow, Department of Pediatrics, School of Medicine, University of Washington, Box 356320, 1959 NE Pacific St. HSB RR349, Seattle, WA 98195, joonhoyu@u.washington.edu.
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Yu
authors.affiliation: Associate Professor, University of Washington - Anthropology, Seattle, WA, jstaylor@u.washington.edu.
authors.forename: Janelle S
authors.initials: JS
authors.lastname: Taylor
authors.affiliation: Professor, University of Washington - Epidemiology, Seattle, WA, keddy@u.washington.edu.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Edwards
authors.affiliation: Associate Professor, University of Washington - Bioethics & Humanities, Seattle, WA, smfllrtn@u.washington.edu.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Fullerton
keywords: bioethics; continental population groups; genetics; interdisciplinary communication; translational research