title: Improving the miscibility of biodegradable polyester/polyphosphazene blends using cross-linkable polyphosphazene.
abstract: Biodegradable polyesters and polyphosphazenes are both promising biomaterials for tissue regeneration. A combination of both materials would provide additional advantages over the individual components in aspects of biocompatibility and osteocompatibility. Applications of polyester/polyphosphazene composites, however, were limited due to the severe phase separation. In this study, cross-linkable poly(glycine ethyl ester-co-hydroxyethyl methacrylate)phosphazene (PGHP) was synthesized. It was blended with poly(L-lactide) (PLLA) or poly(L-lactide-co-glycolide) (PLGA), using chloroform as a mutual solvent, and photo-crosslinked before solvent removal. The resulting PLLA (or PLGA)/PGHP composites demonstrated no significant phase separation due to the restricting function of the crosslinked PGHP polymeric network. In comparison with uncrosslinked blends, the mechanical properties of crosslinked composites were remarkably improved, which indicated their strong potential in bone regeneration applications.
authors.affiliation: Beijing Laboratory of Biomedical Materials, College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
authors.forename: Dingying
authors.initials: D
authors.lastname: Shan
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Huang
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012038:Regeneration; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D003432:Cross-Linking Reagents; D008689:Methacrylates; D009943:Organophosphorus Compounds; D010710:Phosphates; D011091:Polyesters; D011108:Polymers; D012997:Solvents; C000599364:poly(glycine ethyl ester-co-hydroxyethyl methacrylate)phosphazene; C108974:poly(phosphazene); D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002725:Chloroform; D005998:Glycine