title: Nitric oxide donor superparamagnetic iron oxide nanoparticles.
abstract: This work reports a new strategy for delivering nitric oxide (NO), based on magnetic nanoparticles (MNPs), with great potential for biomedical applications. Water-soluble magnetic nanoparticles were prepared through a co-precipitation method by using ferrous and ferric chlorides in acidic solution, followed by a mercaptosuccinic acid (MSA) coating. The thiolated nanoparticles (SH-NPs) were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). The results showed that the SH-NPs have a mean diameter of 10nm and display superparamagnetic behavior at room temperature. Free thiol groups on the magnetite surface were nitrosated through the addition of an acidified nitrite solution, yielding nitrosated magnetic nanoparticles (SNO-NPs). The amount of NO covalently bound to the nanoparticles surface was evaluated by chemiluminescense. The SNO-NPs spontaneously released NO in aqueous solution at levels required for biomedical applications. This new magnetic NO-delivery vehicle has a great potential to generate desired amounts of NO directed to the target location.
authors.affiliation: Instituto de Física, Universidade de São Paulo, São Paulo, São Paulo, 05508-090, Brazil.
authors.forename: Miguel M
authors.initials: MM
authors.lastname: Molina
authors.affiliation: Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Diadema, SP, 09972-270, Brazil.
authors.forename: Amedea B
authors.initials: AB
authors.lastname: Seabra
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, Campinas, São Paulo, 13083-970, Brazil.
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: de Oliveira
authors.affiliation: Instituto de Física, Universidade de São Paulo, São Paulo, São Paulo, 05508-090, Brazil.
authors.forename: Rosangela
authors.initials: R
authors.lastname: Itri
authors.affiliation: Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Diadema, SP, 09972-270, Brazil. Electronic address: haddadps@gmail.com.
authors.forename: Paula S
authors.initials: PS
authors.lastname: Haddad
mesh_terms: D000327:Adsorption; D005290:Ferric Compounds / Q000737:chemistry*; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D020030:Nitric Oxide Donors / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013870:Thiomalates / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D020030:Nitric Oxide Donors; D009573:Nitrites; D013870:Thiomalates; C000499:ferric oxide; C046062:2-thiomalic acid