title: Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation.
abstract: A new chemical derivatisation method to functionalise peptide and protein bound 3-nitrotyrosine residues is described. By transforming 3-nitrotyrosine to 3-azidotyrosine, the method enables 'click chemistry'-based labelling of the 3-nitrotyrosine residues and provides new opportunities for the study of this post-translational modification in biological samples.
authors.affiliation: Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW Australia, Sydney, NSW 2052, Australia. jason.wong@unsw.edu.au.
authors.forename: John Y
authors.initials: JY
authors.lastname: Ng
authors.forename: Jason W H
authors.initials: JW
authors.lastname: Wong
mesh_terms: D001386:Azides / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D001386:Azides; D001391:Azo Compounds; D010455:Peptides; D011506:Proteins; C002744:3-nitrotyrosine; D014443:Tyrosine