title: The survey on cellular and engineered tissue therapies in Europe in 2012.
abstract: Following the coordinated efforts of five established scientific organizations, this report describes activity in Europe for the year 2012 in the area of cellular and engineered tissue therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. Three hundred thirteen teams from 33 countries responded to the cellular and engineered tissue therapy survey: 138 teams from 27 countries provided data on 2157 patients, while a further 175 teams reported no activity. Indications were musculoskeletal/rheumatological disorders (36%; 80% autologous), cardiovascular disorders (25%; 95% autologous), hematology/oncology, predominantly prevention or treatment of graft versus host disease and HSC graft enhancement (19%; 1% autologous), neurological disorders (3%; 99% autologous), gastrointestinal disorders (1%; 71% autologous), and other indications (16%; 79% autologous). Autologous cells were predominantly used for musculoskeletal/rheumatological (42%) and cardiovascular (34%) disorders, whereas allogeneic cells were mainly used for hematology/oncology (60%). The reported cell types were mesenchymal stem/stromal cells (49%), HSC (28%), chondrocytes (11%), dermal fibroblasts (4%), keratinocytes (1%), and others (7%). In 51% of the grafts, cells were delivered after ex vivo expansion, whereas cells were transduced or sorted in 10% and 16%, respectively, of the reported cases. Cells were delivered intra-organ (35%), intravenously (31%), on a membrane or gel (15%), or using 3D scaffolds (19%). The data are compared with those collected since 2008 to identify trends in the field and discussed in the light of recent publications and ongoing clinical studies.
authors.affiliation: 1 Department of Surgery, University Hospital Basel, University of Basel , Basel, Switzerland .
authors.forename: Ivan
authors.initials: I
authors.lastname: Martin
authors.forename: Hilary
authors.initials: H
authors.lastname: Ireland
authors.forename: Helen
authors.initials: H
authors.lastname: Baldomero
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
mesh_terms: D017690:Cell Transplantation / Q000706:statistics & numerical data; D005060:Europe; D005843:Geography; D019538:Health Care Surveys / Q000706:statistics & numerical data*; D006801:Humans; D058028:Research Report; D014019:Tissue Donors; D023822:Tissue Engineering / Q000706:statistics & numerical data*