title: The effect of resveratrol on the recurrent attacks of gouty arthritis.
abstract: Gouty arthritis is characterized by inflammation induced by monosodium urate crystal (MSU) deposition, which is resulted by increase of serum urate concentration. The management of gout, especially the recurrent attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effects of resveratrol on gouty arthritis. Monosodium urate crystal (MSU) was used to induce gouty arthritis in foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneally injected to the mice in the treatment group. Article inflammation and serum uric acid level were investigated to estimate the effect of resveratrol in gout. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in mice, and MSU to induce gouty arthritis. We identified that resveratrol inhibited foot swelling and inflammation-associated 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Shucong
authors.initials: S
authors.lastname: Zheng
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Wang
authors.forename: Huiqing
authors.initials: H
authors.lastname: Zhu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xue
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qiu
authors.forename: Hejian
authors.initials: H
authors.lastname: Zou
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu