title: The power-proportion method for intracranial volume correction in volumetric imaging analysis.
abstract: In volumetric brain imaging analysis, volumes of brain structures are typically assumed to be proportional or linearly related to intracranial volume (ICV). However, evidence abounds that many brain structures have power law relationships with ICV. To take this relationship into account in volumetric imaging analysis, we propose a power law based method-the power-proportion method-for ICV correction. The performance of the new method is demonstrated using data from the PREDICT-HD study.
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa Iowa City, IA, USA.
authors.forename: Dawei
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa Iowa City, IA, USA ; Department of Electrical and Computer Engineering, College of Engineering, University of Iowa Iowa City, IA, USA ; Department of Biomedical Engineering, College of Engineering, University of Iowa Iowa City, IA, USA.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Johnson
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa Iowa City, IA, USA ; Department of Biostatistics, College of Public Health, University of Iowa Iowa City, IA, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Long
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Iowa City, IA, USA.
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Magnotta
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa Iowa City, IA, USA ; Department of Neurology, Carver College of Medicine, University of Iowa Iowa City, IA, USA ; Department of Psychology, University of Iowa Iowa City, IA, USA.
authors.forename: Jane S
authors.initials: JS
authors.lastname: Paulsen
keywords: intracranial volume; magnetic resonance imaging; nonlinear model; power function; power-proportion correction