title: Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution.
abstract: Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to hitherto reported compounds.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. suzuki@applc.keio.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Nishihara
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Emi
authors.initials: E
authors.lastname: Hoshino
authors.forename: Sakura
authors.initials: S
authors.lastname: Suganuma
authors.forename: Moritoshi
authors.initials: M
authors.lastname: Sato
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saitoh
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwasawa
authors.forename: Daniel
authors.initials: D
authors.lastname: Citterio
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism; D049410:Luciferases, Renilla / Q000378:metabolism; D049408:Luminescent Agents / Q000737:chemistry* / Q000378:metabolism; D008163:Luminescent Measurements; D011719:Pyrazines / Q000737:chemistry* / Q000378:metabolism; D048790:Renilla / Q000201:enzymology; D013379:Substrate Specificity
chemical_list: D007093:Imidazoles; D049408:Luminescent Agents; D011719:Pyrazines; C017144:coelenterazine; D049410:Luciferases, Renilla