title: Glycerophosphate/Acylglycerophosphate acyltransferases.
abstract: Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review.
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. ayamashi@pharm.teikyo-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamashita
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. hayashiy@pharm.teikyo-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. n-matsu@pharm.teikyo-u.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. ynsasaki@pharm.teikyo-u.ac.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nemoto-Sasaki
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. s.oka@pharm.teikyo-u.ac.jp.
authors.forename: Saori
authors.initials: S
authors.lastname: Oka
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. tanikawa@pharm.teikyo-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanikawa
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. sugiurat@pharm.teikyo-u.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugiura