title: At the crossroad between obesity and gastric cancer.
abstract: Obesity has reached epidemic proportions worldwide with disproportionate prevalence in different communities and ethnic groups. Recently, the American Medical Association recognized obesity as a disease, which is a significant milestone that opens the possibilities of treating obesity under standardized health plans. Obesity is an inflammatory disease characterized by elevated levels of biomarkers associated with abnormal lipid profiles, glucose levels, and blood pressure that lead to the onset of metabolic syndrome. Interestingly, inflammatory biomarkers, in particular, have been implicated in the risk of developing several types of cancer. Likewise, obesity has been linked to esophageal, breast, gallbladder, kidney, pancreatic, and colorectal cancers. Thus, there exists a link between obesity status and tumor appearance, which may be associated to the differential levels and the circulating profiles of several inflammatory molecules. For example, mediators of the inflammatory responses in both obesity and gastric cancer risk are the same: pro-inflammatory molecules produced by the activated cells infiltrating the inflamed tissues. These molecules trigger pathways of activation shared by obesity and cancer. Therefore, understanding how these different pathways are modulated would help reduce the impact that both diseases, and their concomitant existence, have on society.
authors.affiliation: Stanley S. Scott Cancer Center, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
authors.forename: Jone
authors.initials: J
authors.lastname: Garai
authors.forename: Robert B
authors.initials: RB
authors.lastname: Uddo
authors.forename: Maura C
authors.initials: MC
authors.lastname: Mohler
authors.forename: Nicole
authors.initials: N
authors.lastname: Pelligrino
authors.forename: Richard
authors.initials: R
authors.lastname: Scribner
authors.forename: Melinda S
authors.initials: MS
authors.lastname: Sothern
authors.forename: Jovanny
authors.initials: J
authors.lastname: Zabaleta
mesh_terms: D004032:Diet; D044127:Epigenesis, Genetic; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000235:genetics