title: Image quality of CT angiography with model-based iterative reconstruction in young children with congenital heart disease: comparison with filtered back projection and adaptive statistical iterative reconstruction.
abstract: To retrospectively evaluate the image quality of CT angiography (CTA) reconstructed by model-based iterative reconstruction (MBIR) and to compare this with images obtained by filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR) in newborns and infants with congenital heart disease (CHD). Thirty-seven children (age 4.8 ± 3.7 months; weight 4.79 ± 0.47 kg) with suspected CHD underwent CTA on a 64detector MDCT without ECG gating (80 kVp, 40 mA using tube current modulation). Total dose length product was recorded in all patients. Images were reconstructed using FBP, ASIR, and MBIR. Objective image qualities (density, noise) were measured in the great vessels and heart chambers. The contrast-to-noise ratio (CNR) was calculated by measuring the density and noise of myocardial walls. Two radiologists evaluated images for subjective noise, diagnostic confidence, and sharpness at the level prior to the first branch of the main pulmonary artery. Images were compared with respect to reconstruction method, and reconstruction times were measured. Images from all patients were diagnostic, and the effective dose was 0.22 mSv. The objective image noise of MBIR was significantly lower than those of FBP and ASIR in the great vessels and heart chambers (P < 0.05); however, with respect to attenuations in the four chambers, ascending aorta, descending aorta, and pulmonary trunk, no statistically significant difference was observed among the three methods (P > 0.05). Mean CNR values were 8.73 for FBP, 14.54 for ASIR, and 22.95 for MBIR. In addition, the subjective image noise of MBIR was significantly lower than those of the others (P < 0.01). Furthermore, while FBP had the highest score for image sharpness, ASIR had the highest score for diagnostic confidence (P < 0.05), and mean reconstruction times were 5.1 ± 2.3 s for FBP and ASIR and 15.1 ± 2.4 min for MBIR. While CTA with MBIR in newborns and infants with CHD can reduce image noise and improve CNR more than other methods, it is more time-consuming than the other methods.
authors.affiliation: Department of Biomedical-Engineering, The Graduate School, Pusan National University, Busan, Korea, gshock282@naver.com.
authors.forename: Sung Sil
authors.initials: SS
authors.lastname: Son
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Choo
authors.forename: Ung Bae
authors.initials: UB
authors.lastname: Jeon
authors.forename: Gye Rok
authors.initials: GR
authors.lastname: Jeon
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Nam
authors.forename: Tae Un
authors.initials: TU
authors.lastname: Kim
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Yeom
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Hwang
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Jeong
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Lim
mesh_terms: D000367:Age Factors; D017023:Coronary Angiography / Q000379:methods*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D061330:Multidetector Computed Tomography / Q000379:methods*; D015588:Observer Variation; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D059629:Signal-To-Noise Ratio; D013997:Time Factors