title: Community acquired Panton-Valentine Leukocidin (PVL) positive Methicilin Resistant Staphylococcal aureus cerebral abscess in an 11-month old boy: a case study.
abstract: BACKGROUND
  Brain abscess are uncommon childhood infection. Brain abscess caused by Panton-Valentine Leukocidin positive Community acquired Methicillin Resistant Staphylococcal aureus have never been reported in the United Kingdom.
  
  
  METHODS
  We report a case of a previously well 11-month old boy of Indian origin who developed a parietal lobe abscess from PVL positive CA-MRSA.
  
  
  CONCLUSIONS
  This case is one of the few described cases of brain abscess caused by PVL CA-MRSA in children. The unusual (insidious) presentation, the absence of a clear staphylococcal focus and the unexpected finding of a CA-MRSA in this patient highlight the challenges of managing such cases in clinical settings and the potential future risk to public health.
authors.affiliation: London School of Hygiene and Tropical Medicine, Clinical Research Unit, London, UK. wmutale@yahoo.com.
authors.forename: Wilbroad
authors.initials: W
authors.lastname: Mutale
authors.forename: Keya M
authors.initials: KM
authors.lastname: Sahay
authors.forename: John
authors.initials: J
authors.lastname: Hartley
authors.forename: Dominic
authors.initials: D
authors.lastname: Thompson
authors.forename: Didi
authors.initials: D
authors.lastname: Ratnasinghe
authors.forename: Lee
authors.initials: L
authors.lastname: Hudson
authors.forename: Eleanor
authors.initials: E
authors.lastname: Hulse
authors.forename: Greg
authors.initials: G
authors.lastname: Fellows
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000302:isolation & purification*; D001922:Brain Abscess / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D017714:Community-Acquired Infections; D005098:Exotoxins / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000302:isolation & purification*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D010296:Parietal Lobe / Q000187:drug effects / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin