title: Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
abstract: Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The present study is to investigate whether FCER1A polymorphisms are associated with the risk of CSU, and to determine whether these polymorphisms influence the therapeutic efficacy of nonsedating H1-antihistamines. 191 CSU patients treated by nonsedating H1-antihistamines monotherapy (including desloratadine, mizolastine or fexofenadine) were prospectively enrolled in this study. The response to antihistamines monotherapy was assessed by urticaria activity score (UAS7) after 4 weeks of treatment. FCER1A rs2298805, rs10908703 and rs2494262 genotypes were determined by Sequenom Mass Array technology or direct sequencing. There was significant difference in the allele frequency of rs2298805A between CSU patients and 177 healthy subjects (5.3 vs 10.2 %, P = 0.012, OR = 0.491, 95 % CI 0.278-0.865), and also significant difference in the allele frequency of rs2298805A between effective and ineffective groups (7.5 vs 1.0 %, P = 0.015, OR = 8.328, 95 %CI 1.1-63.039). In addition, rs2298805 polymorphism was significantly associated with total serum IgE concentrations (P = 0.011). There were no differences in the rs10908703 and rs2494262 either between CSU patients and healthy controls, or between effective and ineffective groups. These data suggest that rs2298805 might be associated with risk for CSU and the therapeutic efficacy of nonsedating H1-antihistamines in Chinese patients with CSU.
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
authors.forename: Aiyuan
authors.initials: A
authors.lastname: Guo
authors.forename: Wu
authors.initials: W
authors.lastname: Zhu
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.forename: Shu
authors.initials: S
authors.lastname: Wen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
authors.forename: Jianglin
authors.initials: J
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Wangqing
authors.initials: W
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Siyu
authors.initials: S
authors.lastname: Yan
authors.forename: Yijing
authors.initials: Y
authors.lastname: He
authors.forename: Zhaoqian
authors.initials: Z
authors.lastname: Liu
authors.forename: Honghao
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001562:Benzimidazoles / Q000627:therapeutic use; D002681:China; D005260:Female; D060005:Genotyping Techniques; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D017336:Loratadine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics*; D016593:Terfenadine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014581:Urticaria / Q000235:genetics*; D055815:Young Adult
chemical_list: D001562:Benzimidazoles; C475664:FCER1A protein, human; D039563:Histamine H1 Antagonists, Non-Sedating; D017455:Receptors, IgE; C076170:mizolastine; D007073:Immunoglobulin E; D017336:Loratadine; D016593:Terfenadine; C093230:fexofenadine; C121345:desloratadine