title: Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes.
abstract: Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type di-aqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contributions of inner- and second spheres of hydration.
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza, 52, 10126, Torino, Italy.
authors.forename: Dale
authors.initials: D
authors.lastname: Lawson
authors.forename: Alessandro
authors.initials: A
authors.lastname: Barge
authors.forename: Enzo
authors.initials: E
authors.lastname: Terreno
authors.forename: David
authors.initials: D
authors.lastname: Parker
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D014867:Water; D005682:Gadolinium