title: Novel nickel contact dermatitis in a patient taking isotretinoin.
abstract: There are many reports about contact dermatitis to nickel and side effects of isotretinoin, but the development of contact dermatitis to a previously tolerated allergen while taking isotretinoin is not well described. We report the case of a 19-year-old man who developed a new nickel allergy during isotretinoin treatment. We theorize that thinning of the stratum corneum by this medication allows for greater antigen presentation and thus sensitization to contact allergens.
authors.affiliation: Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota.
authors.forename: John
authors.initials: J
authors.lastname: Conely
authors.forename: Ingrid
authors.initials: I
authors.lastname: Polcari
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D009532:Nickel / Q000276:immunology*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D009532:Nickel; D015474:Isotretinoin