title: A new bibenzyl derivative with nuclear factor-kappaB inhibitory activity from Schefflera arboricola (Araliaceae).
abstract: A new bibenzyl derivative (1), 4-acetoxy-3,5,3',4'-tetramethoxybibenzyl, along with eight known compounds (2-9), was isolated from the twigs and leaves of Schefflera arboricola (Araliaceae). The isolated compounds were elucidated mainly by means of one-dimensional, two-dimensional NMR and MS, and by comparison with the literature data. Compounds 2-5 and 7-9 are first reported from this plant. In the in vitro assays, compound 1 displayed moderate nuclear factor-kappaB inhibitory activity.
authors.affiliation: a School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou , Guangdong 510006 , P.R. China.
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Zi-Zhe
authors.initials: ZZ
authors.lastname: Cai
authors.forename: Long-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Xin-Jun
authors.initials: XJ
authors.lastname: Xu
authors.forename: Shao-Rui
authors.initials: SR
authors.lastname: Chen
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Zhao
mesh_terms: D000818:Animals; D027481:Araliaceae / Q000737:chemistry*; D001632:Bibenzyls / Q000737:chemistry*; D002460:Cell Line; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: C000600494:4-acetoxy-3,5,3',4'-tetramethoxybibenzyl; D001632:Bibenzyls; D016328:NF-kappa B
keywords: Schefflera arboricola; bibenzyl derivative; nuclear factor-kappaB inhibitory activity