title: Application of the chick embryo chorioallantoic membrane in neurosurgery disease.
abstract: The chick embryo chorioallantoic membrane (CAM) is a highly vascularized extraembryonic membrane. Because of its ease of accessibility, extensive vascularization and immunodeficient environment, the CAM has been broadly used in the oncology, biology, pharmacy, and tissue regeneration research. The present review summarizes the application of the CAM in neurosurgery disease research. We focused on the use of the CAM as an assay for the research of glioma, vascular anomalies, Moyamoya Disease, and the blood-brain barrier.
authors.affiliation: Department of Neurosurgery, Jilin University First Hospital, Changchun 130021, China.
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Yuan
authors.affiliation: Department of Neurosurgery, Jilin University First Hospital, Changchun 130021, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Jilin University First Hospital, Changchun 130021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Jilin University First Hospital, Changchun 130021, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, Jilin University First Hospital, Changchun 130021, China.
authors.forename: Jin-Lu
authors.initials: JL
authors.lastname: Yu
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000033:anatomy & histology / Q000502:physiology; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000033:anatomy & histology* / Q000098:blood supply / Q000502:physiology*; D005910:Glioma / Q000098:blood supply / Q000473:pathology; D064593:Heterografts; D006801:Humans; D023421:Models, Animal; D009072:Moyamoya Disease / Q000209:etiology / Q000473:pathology; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D009493:Neurosurgery; D057170:Translational Research, Biomedical; D014652:Vascular Diseases / Q000209:etiology / Q000473:pathology
keywords: blood brain barrier.; chorioallantoic membrane; glioma; vascular disease