title: Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones.
abstract: In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C-H activation methodology exhibits a broad substrate scope such as different substituted indoles, pyrroles, and other azoles. Further synthetic applications of the alkylation products can lead to more attractive 3,4-fused tricyclic indoles.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
mesh_terms: D000388:Air; D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D007211:Indoles; D007659:Ketones; D002244:Carbon; D012428:Ruthenium