title: [A new conceptual approach for searching for molecular causes of diabetes mellitus, based on the study of functioning of hormonal signaling systems].
abstract: The review deals with analysis and generalization of the data obtained by authors on abnormalities in hormonal signal systems in diabetes mellitus (DM)--in rats with experimental models of DM of the types 1 and 2, in patients with DM, and in invertebrates (mollucs) with experimental diabetes-like state. Changes of functional state of hormonal signal systems regulated by different hormones, including biogenic amines and peptides of the insulin group, in a wide spectrum of tissues are discussed. The conclusion is made that disturbances in hormonal signal systems are the key molecular causes of physiological and metabolic abnormalities occurring in the types 1 and 2 DM. A concept on polyhormonal genesis of DM and the systemic nature of disturbances in the hormone-regulated signaling cascades under conditions of DM is formulated.
authors.forename: M N
authors.initials: MN
authors.lastname: Pertseva
authors.forename: L A
authors.initials: LA
authors.lastname: Kuznetsova
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D006728:Hormones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051381:Rats; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D006728:Hormones