title: 25-hydroxyvitamin D status is associated with chronic cerebral small vessel disease.
abstract: OBJECTIVE
  The aim of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) and neuroimaging correlates of cerebral small vessel disease.
  
  
  METHODS
  We identified 759 consecutive patients with acute ischemic stroke or transient ischemic attack. Lacunes, white matter hyperintensity, and cerebral microbleed (CMB) were assessed using MR images. Deep CMB was defined as the presence of CMB in basal ganglia, thalamus, or brain stem. The association between 25(OH)D and small vessel disease was tested using linear and logistic regression analyses.
  
  
  RESULTS
  Mean age was 68 (±13) years. Mean level of 25(OH)D was 34.1±17.8 nmol/L. On bivariate analysis, a 25-nmol/L decrease in 25(OH)D was associated with lacunes (regression coefficient, 0.23; 95% confidence interval [CI], 0.02-0.45), severe white matter hyperintensity (odds ratio, 2.05; 95% CI, 1.41-3.08), and deep CMB (odds ratio, 1.28; 95% CI, 1.01-1.63). Also, 25(OH)D deficiency (≤25 nmol/L) was associated with lacunes (regression coefficient, 0.5; 95% CI, 0.04-0.95), severe white matter hyperintensity (odds ratio, 2.74; 95% CI, 1.31-6.45), and deep CMB (odds ratio, 1.68; 95% CI, 1.03-2.78). The association remained significant even after multivariable adjustment and in the subgroup of previously healthy patients.
  
  
  CONCLUSIONS
  25(OH)D is inversely associated with lacunes, white matter hyperintensity, and deep CMB. Our findings suggest that 25(OH)D is linked to small vessel disease, and in future trials it should be tested whether 25(OH)D supplementation can prevent small vessel disease.
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Pil-Wook
authors.initials: PW
authors.lastname: Chung
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.). kwangyeol.park@gmail.com.
authors.forename: Kwang-Yeol
authors.initials: KY
authors.lastname: Park
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Shin
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Moo-Seok
authors.initials: MS
authors.lastname: Park
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Yun Jae
authors.initials: YJ
authors.lastname: Chung
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Sam-Yeol
authors.initials: SY
authors.lastname: Ha
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Ahn
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Shin
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Yong Bum
authors.initials: YB
authors.lastname: Kim
authors.affiliation: From the Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (P.-W.C., Y.B.K., H.-S.M.); Department of Neurology (K.-Y.P., J.-M.K., D.-W.S., M.-S.P., S.-W.A., H.-W.S.) and Division of Endocrinology, Department of Internal Medicine (Y.J.C.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea; and Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea (S.-Y.H.).
authors.forename: Heui-Soo
authors.initials: HS
authors.lastname: Moon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000473:pathology; D059345:Cerebral Small Vessel Diseases / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000453:epidemiology* / Q000473:pathology; D013788:Thalamus / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*; D066127:White Matter / Q000473:pathology*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: vitamin D