title: Ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry analysis of the impact of bran-processing on the chemical profile of Radix Paeoniae Alba (Baishao).
abstract: In this study, a rapid and versatile ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry-based chemical profiling approach was applied to evaluate chemical constitution of crude and processed Radix Paeoniae Alba (RPA) samples. A total of 44 compounds were identified, among which the contents of 9 compounds in processed samples were obviously decreased and 8 compounds were increased. Furthermore, compound 28 was not found in RPA sample after stir-frying with wheat bran. The proposed method provided a chemical basis for exploring the processed mechanism of herbal medicine.
authors.affiliation: a Department of Pharmacy , Wenzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University , Wenzhou , P.R. China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Chen
authors.forename: Baochang
authors.initials: B
authors.lastname: Cai
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Radix Paeoniae Alba; chemical profile; processed mechanism; ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry