title: Reprogramming of prostate cancer cells--technical challenges.
abstract: Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.
authors.affiliation: School of Pharmacology, Federal University of Goiás, Goiânia, Brazil, gisa_borges5@hotmail.com.
authors.forename: Gisely T
authors.initials: GT
authors.lastname: Borges
authors.forename: Eneida F
authors.initials: EF
authors.lastname: Vêncio
authors.forename: Ricardo Z N
authors.initials: RZ
authors.lastname: Vêncio
authors.forename: Robert L
authors.initials: RL
authors.lastname: Vessella
authors.forename: Carol B
authors.initials: CB
authors.lastname: Ware
authors.forename: Alvin Y
authors.initials: AY
authors.lastname: Liu
mesh_terms: D054337:Cell Dedifferentiation; D045744:Cell Line, Tumor; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D008297:Male; D014411:Neoplastic Stem Cells / Q000166:cytology*; D025341:Principal Component Analysis; D011467:Prostate / Q000166:cytology*; D011471:Prostatic Neoplasms