title: Three-dimensional conformal planning with low-segment multicriteria intensity modulated radiation therapy optimization.
abstract: OBJECTIVE
  The purpose of this study was to evaluate automated multicriteria optimization (MCO), which is designed for intensity modulated radiation therapy (IMRT) but invoked with limited segmentation, to efficiently produce high-quality 3-dimensional (3D) conformal radiation therapy (3D-CRT) plans.
  
  
  METHODS
  Treatment for 10 patients previously planned with 3D-CRT to various disease sites (brain, breast, lung, abdomen, pelvis) was replanned with a low-segment inverse MCO technique. The MCO-3D plans used the same beam geometry of the original 3D plans but were limited to an energy of 6 MV. The MCO-3D plans were optimized with fluence-based MCO IMRT and then, after MCO navigation, segmented with a low number of segments. The 3D and MCO-3D plans were compared by evaluating mean dose for all structures, D95 (dose that 95% of the structure receives) and homogeneity indexes for targets, D1 and clinically appropriate dose-volume objectives for individual organs at risk (OARs), monitor units, and physician preference.
  
  
  RESULTS
  The MCO-3D plans reduced the mean doses to OARs (41 of a total of 45 OARs had a mean dose reduction; P << .01) and monitor units (7 of 10 plans had reduced monitor units; the average reduction was 17% [P = .08]) while maintaining clinical standards for coverage and homogeneity of target volumes. All MCO-3D plans were preferred by physicians over their corresponding 3D plans.
  
  
  CONCLUSIONS
  High-quality 3D plans can be produced by use of MCO-IMRT optimization, resulting in automated field-in-field-type plans with good monitor unit efficiency. Adoption of this technology in a clinic could improve plan quality and streamline treatment plan production by using a single system applicable to both IMRT and 3D planning.
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Fazal
authors.initials: F
authors.lastname: Khan
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: dcraft@mgh.harvard.edu.
authors.forename: David
authors.initials: D
authors.lastname: Craft
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*