title: Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012.
abstract: p-Aminosalicylic acid (PAS) is an important compound for treating multidrug-resistant tuberculosis (TB). Previous studies showed that thyA mutations are often related to PAS resistance in clinical isolates. We performed a systematic analysis of isolate genotypes and detected mutations in three folate pathway genes (folC, thyA, and ribD) in 61.1% (127/208) of PAS-resistant isolates, including 11 double mutants. This result expands our knowledge about the distribution and frequency of mutations related to PAS resistance in mycobacterial clinical isolates.
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Liguo
authors.initials: L
authors.lastname: Liu
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Dai
authors.affiliation: Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China zdsys@vip.sina.com hairong.huangcn@gmail.com.
authors.forename: Hairong
authors.initials: H
authors.lastname: Huang
authors.affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China zdsys@vip.sina.com hairong.huangcn@gmail.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
mesh_terms: D010131:Aminosalicylic Acid / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D002681:China; D005838:Genotype; D006801:Humans; D009154:Mutation / Q000235:genetics; D009161:Mycobacterium / Q000187:drug effects* / Q000235:genetics*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D010131:Aminosalicylic Acid