title: Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis.
abstract: A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.
authors.affiliation: Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam.
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Chuong
authors.affiliation: Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam.
authors.forename: Nguyen Thi Thu
authors.initials: NT
authors.lastname: Huong
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City, 227 Nguyen Van Cu, District 5, Ho Chi Minh City 227-01, Vietnam. tmhung801018@gmail.com.
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.affiliation: Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam. congluan53@gmail.com.
authors.forename: Tran Cong
authors.initials: TC
authors.lastname: Luan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D032501:Huperzia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D032502:Lycopodium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D012717:Sesquiterpenes; C050426:huperzine A; C053016:huperzine B; C058370:huperzinine