title: Enamine/enolate-mediated organocatalytic azide-carbonyl [3+2] cycloaddition reactions for the synthesis of densely functionalized 1,2,3-triazoles.
abstract: Organocatalytic click! Recent advances in the metal-free enamine/enolate-mediated azide-carbonyl [3+2] cycloaddition reaction are discussed. These approaches require neither a metal catalyst nor alkyne substrates. Owing to the ready availability of carbonyl compounds, these methods thus offer excellent alternatives for the synthesis of 1,4-/1,5-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306 (India). ramsastry@iisermohali.ac.in, ramsastrys@gmail.com.
authors.forename: Sripada S V
authors.initials: SS
authors.lastname: Ramasastry
mesh_terms: D000588:Amines / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000588:Amines; D001386:Azides; D014230:Triazoles
keywords: 1,2,3-triazoles; azides; click chemistry; enols; organocatalysis