title: MicroRNAs regulate immune system via multiple targets.
abstract: MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression. Each miRNA may suppress multiple mRNA targets, while one mRNA can be targeted by many miRNAs for precise control of a wide range of cellular processes. The important role of miRNAs in the immune system is highlighted by the conditional Dicer knockout mouse, which exhibited profound aberrant development and function of immune cells. One particular miRNA, miR-155, is highly expressed and plays important role in lymphocytes. In this review we focused on the role of miRNA, especially miR-155, via their predicted and known mRNA targets in innate and adaptive immunity. Finally, we discussed the potential of miRNAs as novel targets for the diagnosis and therapy of immune system diseases.
authors.affiliation: Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China and Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
authors.forename: Sujie
authors.initials: S
authors.lastname: Jia
authors.affiliation: Hunan Key Laboratory of Medical Epigenomics and Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
authors.forename: Hanyue
authors.initials: H
authors.lastname: Zhai
authors.affiliation: Hunan Key Laboratory of Medical Epigenomics and Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007113:Immunity, Innate / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs