title: Magnetic resonance enterography for assessment of intestinal graft-versus-host disease after allogeneic stem cell transplantation.
abstract: OBJECTIVE
  To determine the diagnostic performance of MR enterography (MRE) for detection and grading of gastrointestinal graft-versus-host disease (GI GvHD) after hematopoietic stem cell transplantation (SCT).
  
  
  METHODS
  Forty-one patients with known GvHD or suspected GvHD underwent MRE and GI endoscopy with multi-level biopsies. MRE images were reviewed for presence of intestinal wall inflammation. Clinical grading of GI GvHD was performed. Histopathological evaluation (HPE) served as the reference standard.
  
  
  RESULTS
  Overall, MRE demonstrated a per-patient sensitivity of 81.5 % for detection of GI GvHD. The most common findings were intestinal wall thickening (81.5 % of GvHD patients), luminal stenosis (81.5 %), mural contrast enhancement (70.4 %), and ascites (59.3 %). These findings were also observed in other conditions than GvHD. The most frequently involved intestinal segment was the sigmoid colon (63.0 %), followed by the ileum (59.3 %) and the jejeunum (51.9 %). The number of involved segments (r s =0.54, p =0.009) correlated significantly with clinical severity as determined by GvHD grading.
  
  
  CONCLUSIONS
  After allogeneic stem cell transplantation, MRE may (1) contribute to detection and localization of GI GvHD, and (2) add information indicating the clinical severity of disease, but findings are unspecific. False negative results may be observed not only in low-grade GI GvHD.
  
  
  CONCLUSIONS
  • Magnetic resonance enterography (MRE) allows for detection of GI GvHD • Common findings are wall thickening, stenosis, mural contrast enhancement, and ascites • The extent of GI involvement on MRE correlates with clinical severity of GvHD • Involvement of sigmoid colon and small intestine is common • Findings are unspecific and also observed in other conditions, e.g. infectious enteritis.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Derlin.Thorsten@mh-hannover.de.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Azien
authors.initials: A
authors.lastname: Laqmani
authors.forename: Simon
authors.initials: S
authors.lastname: Veldhoen
authors.forename: Ivayla
authors.initials: I
authors.lastname: Apostolova
authors.forename: Francis
authors.initials: F
authors.lastname: Ayuk
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Kröger
authors.forename: Peter
authors.initials: P
authors.lastname: Bannas
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D041981:Gastrointestinal Tract / Q000473:pathology; D006086:Graft vs Host Disease / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D033581:Stem Cell Transplantation; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA