title: Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix.
abstract: We evaluated the antioxidant properties of four main flavones from Scutellaria baicalensis: baicalein, wogonin and their glucuronides - baicalin and wogonoside. We used three in vitro assays: free radical scavenging with 2,2'-diphenylpicrylhydrazyl radical, transition metal ions reducing power by phosphomolybdenum assay and inhibition of the hydroxyl radical-induced peroxidation of linoleic acid assay. All flavones have antioxidant capacity, which differs depending on the structure and mechanisms of activity. In all tests, only baicalein - the aglycone with three adjacent hydroxyl groups - exhibited consistent antioxidant effect. Wogonin protected linoleic acid against oxidation. Baicalin displayed less potent antioxidant properties whereas wogonoside did not have significant antioxidant activity.
authors.affiliation: a Department of Pharmaceutical Biology and Botany , Medical University of Wrocław , Borowska 211, 50-556 Wrocław , Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Woźniak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dryś
authors.forename: Adam
authors.initials: A
authors.lastname: Matkowski
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry; D047309:Flavones / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D031364:Scutellaria baicalensis
chemical_list: D000975:Antioxidants; D044950:Flavanones; D047309:Flavones; D005419:Flavonoids; D016166:Free Radical Scavengers; D005960:Glucosides; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; C038044:baicalin; C006680:baicalein; C473995:wogonoside; C085514:wogonin
keywords: Scutellaria baicalensis; antioxidant; baicalin; lipid peroxidation; wogonin