title: BRAF V600E mutation as a predictive factor of anti-EGFR monoclonal antibodies therapeutic effects in metastatic colorectal cancer: a meta-analysis.
abstract: OBJECTIVE
  To investigate the correlation between BRAF V600E mutation and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) therapeutic effects in metastatic colorectal cancer.
  
  
  METHODS
  Studies were included into meta-analysis to investigate the association between BRAF V600E mutation and clinical outcome in metastatic colorectal cancer patients treated with anti-EGFR MoAbs.
  
  
  RESULTS
  A total of 7 studies were included in this meta-analysis. The 7 studies included 1352 patients in total, sample sizes ranged from 67 to 493. Objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) were collected from included studies and were used to assess the strength of the relation. In patients with wild-type KRAS, the pooled odds ratio for ORR of mutant BRAF over wild-type BRAF was 0.27 (95% CI=0.10-0.70). BRAF mutation predicted a deterioration in PFS and OS in wild-type KRAS patients treated with anti-EGFR MoAbs (hazard ratio=2.78, 95% CI=1.62-4.76; hazard ratio=2.54, 95% CI=1.93-3.32).
  
  
  CONCLUSIONS
  BRAF V600E mutation is related to lack of response and worse survival in wild-type KRAS metastatic colorectal cancer patients treated with anti-EGFR MoAbs.
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Hu
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Qi-bin
authors.initials: QB
authors.lastname: Song
authors.affiliation: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wei
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology; D066246:ErbB Receptors / Q000276:immunology*; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis / Q000276:immunology*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*
chemical_list: D000911:Antibodies, Monoclonal; D066246:ErbB Receptors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf