title: Case report of PET/CT imaging of a patient with neuroblastoma using 18F-FPBG.
abstract: The use of an (18)F-labeled radiopharmaceutical for positron emission tomography (PET) imaging of sympathetic neuronal activity has a tremendous clinical impact because it circumvents the substantial drawbacks of the prototypical imaging agent, (123)I-metaiodobenzylguanidine (MIBG). We describe a 14-year-old male patient who had neuroblastoma and underwent (18)F-fluoropropylbenzylguanidine (FPBG) PET/computed tomography (CT). We compared the findings of (18)F-FPBG PET/CT with those of (123)I-MIBG γ scintigraphy. (18)F-FPBG PET/CT readily demonstrated a focal lesion in the left tibia, but the lesion was not seen using (123)I-MIBG scintigraphy. Surgical resection proved the presence of a neuroblastoma lesion in the left tibia. To the best of our knowledge, our study was the first to use an (18)F-labeled radiopharmaceutical for evaluating sympathetic neuronal activity in neuroblastoma. We suggest that (18)F-FPBG is a promising PET agent for imaging sympathetic neuronal activity in neuroblastoma.
authors.affiliation: Departments of Nuclear Medicine.
authors.forename: Minseok
authors.initials: M
authors.lastname: Suh
authors.affiliation: Pathology, and.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea;
authors.forename: Hyoung Soo
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Nuclear Medicine, Konkuk University School of Medicine, Chungju, South Korea; and.
authors.forename: Young
authors.initials: Y
authors.lastname: So
authors.affiliation: Departments of Nuclear Medicine.
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Lee
authors.affiliation: Departments of Nuclear Medicine, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, South Korea wwlee@snu.ac.kr.
authors.forename: Won Woo
authors.initials: WW
authors.lastname: Lee
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006146:Guanidines; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009447:Neuroblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013977:Tibia / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D006146:Guanidines; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: fluoropropylbenzylguanidine; metaiodobenzylguanidine; neuroblastoma; positron emission tomography