title: Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.
abstract: Published data on the association between DNA methyltransferase (DNMT) 3B -149C/T polymorphism and cancer risk remain inconclusive. To derive a more precise estimation for this association, we performed a meta-analysis of 5,903 cancer cases and 8,132 controls from 22 published case-control studies. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Our meta-analysis suggested that DNMT3B -149C/T polymorphism was associated with the risk of head and neck cancer under heterozygote comparison (OR 0.73, 95 % CI 0.59-0.90) and dominant model (OR 1.75, 95 % CI 0.62-0.92), although no evidence of association between DNMT3B -149C/T polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR 0.96, 95 % CI 0.86-1.09; heterozygote comparison: OR 1.07, 95 % CI 0.86-0.32; dominant model: OR 1.03, 95 % CI 0.85-1.25; recessive model: OR 0.93, 95 % CI 0.8-1.08). More studies are needed to detect DNMT3B -149C/T polymorphism and its association with cancer in different ethnic populations incorporated with environment exposures in the susceptibility of different kinds of cancer.
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First People's Hospital of Yichang, 2# Jiefang Road, Yichang, 443000, Hubei Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Songtao
authors.initials: S
authors.lastname: Du
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Zhang
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Wu
authors.forename: Jixiang
authors.initials: J
authors.lastname: Ni
mesh_terms: D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000097584:DNA Methyltransferase 3B
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D000097584:DNA Methyltransferase 3B