title: Breast conserving surgery in multicentric breast cancer, preliminary data of our experience.
abstract: BACKGROUND
  It is widely supported that multicentric disease of the breast (MCDB) is a contraindication of breast conservative surgery (BCS).
  
  
  METHODS
  This is a multicentric study (two breast cancer units from Greece, one from France) involving patients with at least two primary tumors in separate quadrants of the breast and no diffuse suspicious microcalcifications on mammography. Sixty-one patients were included in the study, but 49 were followed up to the end. Patients were randomly assigned in total mastectomy (TM) and BCS groups. End point of the study was disease-free survival rates three and five years after initial operation.
  
  
  RESULTS
  Three years after BCS, local recurrence (LR) was observed in two patients (7%) and one after five years (total recurrence rate: 11%). A TM was performed in these patients, and in two there was no LR or distant metastasis (DM) five years after. The third patient was disease free two-years later. Three years after TM, eight patients (36.4%) had DM and 14 (63.6%) did not (p = 0.004). Five years after TM, eight patients (36.4%) had DM and 14 patients (63.6%) di not (p = 0.03).
  
  
  CONCLUSIONS
  The results showed that conservative surgery was an alternative surgical option in multicentric breast cancer with good results regarding disease-free survival and recurrence.
authors.forename: S
authors.initials: S
authors.lastname: Zervoudis
authors.forename: G
authors.initials: G
authors.lastname: Iatrakis
authors.forename: P
authors.initials: P
authors.lastname: Mares
authors.forename: L
authors.initials: L
authors.lastname: Boileau
authors.forename: I
authors.initials: I
authors.lastname: Grammatikakis
authors.forename: N
authors.initials: N
authors.lastname: Evangelinakis
authors.forename: J P
authors.initials: JP
authors.lastname: Daures
authors.forename: I
authors.initials: I
authors.lastname: Leteuff
authors.forename: A
authors.initials: A
authors.lastname: Avgoulea
authors.forename: T
authors.initials: T
authors.lastname: Stefos
authors.forename: I
authors.initials: I
authors.lastname: Navrozoglou
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging