title: Use of systemic therapy in the treatment of choroidal metastases from breast cancer.
abstract: This is a case report on the use of systemic therapy to successfully regress choroidal metastases due to breast cancer. The choroid is the commonest site for intraocular metastatic disease. Breast and lung cancer are frequently the primary malignancies. Traditionally, choroidal metastases are treated with local therapy to the eye including using either external beam radiotherapy, brachytherapy or, recently, with photodynamic therapy. We report on the impressive results obtained with the use of palliative paclitaxel chemotherapy and trastuzumab after only 8 weeks. Funduscopic images and ultrasound findings support this.
authors.affiliation: Department of Oncology, Weston Park Hospital, Sheffield, UK.
authors.forename: Mymoona
authors.initials: M
authors.lastname: Alzouebi
authors.affiliation: Department of Oncology, Weston Park Hospital, Sheffield, UK.
authors.forename: Sundareswaran
authors.initials: S
authors.lastname: Ramakrishnan
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Rennie
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Sachin
authors.initials: S
authors.lastname: Salvi
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D002830:Choroid Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D000068878:Trastuzumab; C508053:ERBB2 protein, human