title: The effect of raloxifene on left ventricular hypertrophy in postmenopausal women: A prospective, randomized, and controlled study.
abstract: OBJECTIVE
  In healthy women, there is a progressive age-related increase in myocardial mass that is not seen in their male counterparts and occurs primarily in postmenopausal women. Raloxifene is a selective estrogen receptor modulator that has estrogenic actions on bone and the cardiovascular system. The aim of this study was to investigate the effect of raloxifene on myocardial hypertrophy in postmenopausal patients.
  
  
  METHODS
  A total of 22 postmenopausal osteoporotic women were included in this open-label, randomized, prospective, controlled study. Patients were randomized into two groups: 11 of the patients (group 1) were treated with raloxifene 60 mg/day, and the other 11 patients (group 2) were defined as the control group. Quantitative 2-dimensional and M-mode echocardiographic examination was performed in all patients at the beginning and repeated at the end of the 6-month follow-up period. Left ventricle mass (LVM) and left ventricle mass index (LVMI) were calculated for all patients.
  
  
  RESULTS
  The mean age of the patients was 57.2±3.9 years, and baseline clinical characteristics and echocardiographic parameters were similar between the two groups. After 6 months of raloxifene treatment, there was no difference in echocardiographic parameters of LVM and LVMI compared with the control group (201.2±25.9 gr vs. 169.7±46.2 gr, p=0.14 and 120.4±25.9 gr/m2 vs. 105.5±26.3 gr/m2, p=0.195, respectively). There was also no significant difference in LVM and LVMI in the within-group analysis of both groups.
  
  
  CONCLUSIONS
  Raloxifene therapy does not affect myocardial hypertrophy in postmenopausal women after 6 months of treatment.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey. ugurabbasbal@yahoo.com.
authors.forename: Uğur Abbas
authors.initials: UA
authors.lastname: Bal
authors.forename: İlyas
authors.initials: İ
authors.lastname: Atar
authors.forename: Mesut
authors.initials: M
authors.lastname: Öktem
authors.forename: Hulusi B
authors.initials: HB
authors.lastname: Zeyneloğlu
authors.forename: Aylin
authors.initials: A
authors.lastname: Yıldırır
authors.forename: Esra
authors.initials: E
authors.lastname: Kuşcu
authors.forename: Haldun
authors.initials: H
authors.lastname: Müderrisoğlu
mesh_terms: D000284:Administration, Oral; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000517:prevention & control*; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride