title: The IPD and IMGT/HLA database: allele variant databases.
abstract: The Immuno Polymorphism Database (IPD) was developed to provide a centralized system for the study of polymorphism in genes of the immune system. Through the IPD project we have established a central platform for the curation and publication of locus-specific databases involved either directly or related to the function of the Major Histocompatibility Complex in a number of different species. We have collaborated with specialist groups or nomenclature committees that curate the individual sections before they are submitted to IPD for online publication. IPD consists of five core databases, with the IMGT/HLA Database as the primary database. Through the work of the various nomenclature committees, the HLA Informatics Group and in collaboration with the European Bioinformatics Institute we are able to provide public access to this data through the website http://www.ebi.ac.uk/ipd/. The IPD project continues to develop with new tools being added to address scientific developments, such as Next Generation Sequencing, and to address user feedback and requests. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the immunogenetics community, and the wider research and clinical communities.
authors.affiliation: Anthony Nolan Research Institute, Hampstead, London, NW3 2QG, UK UCL Cancer Institute, University College London, Hampstead, London, NW3 2QG, UK.
authors.forename: James
authors.initials: J
authors.lastname: Robinson
authors.affiliation: Anthony Nolan Research Institute, Hampstead, London, NW3 2QG, UK.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Halliwell
authors.affiliation: Anthony Nolan Research Institute, Hampstead, London, NW3 2QG, UK.
authors.forename: James D
authors.initials: JD
authors.lastname: Hayhurst
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Flicek
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5136, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Parham
authors.affiliation: Anthony Nolan Research Institute, Hampstead, London, NW3 2QG, UK UCL Cancer Institute, University College London, Hampstead, London, NW3 2QG, UK steven.marsh@ucl.ac.uk.
authors.forename: Steven G E
authors.initials: SG
authors.lastname: Marsh
mesh_terms: D000483:Alleles; D016824:Antigens, Human Platelet; D045744:Cell Line, Tumor; D030541:Databases, Genetic; D006680:HLA Antigens / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D020407:Internet; D008285:Major Histocompatibility Complex; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics; D012984:Software
chemical_list: D016824:Antigens, Human Platelet; D006680:HLA Antigens; D054340:Receptors, KIR