title: Invasive Bordetella holmesii infections.
abstract: Bordetella holmesii is a rare cause of invasive human disease. The fastidious and unusual nature of this organism makes routine isolation and identification challenging. We report two cases of B. holmesii bacteremia that were rapidly identified by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) when standard techniques failed to provide speciation. There are no current standards for susceptibility testing or treatment recommendations. The rare occurrence and challenges in identifying this pathogen led us to perform a comprehensive review of the epidemiology, clinical presentations, and treatment options for this potentially invasive pathogen.
authors.affiliation: From the Division of Infectious Diseases.
authors.forename: Joel T
authors.initials: JT
authors.lastname: Fishbain
authors.forename: Kathleen
authors.initials: K
authors.lastname: Riederer
authors.forename: Hadi
authors.initials: H
authors.lastname: Sawaf
authors.forename: Rupal
authors.initials: R
authors.lastname: Mody
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001884:Bordetella / Q000302:isolation & purification; D001885:Bordetella Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D002939:Ciprofloxacin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin
keywords: Bordetella; mass; matrix-assisted laser desorption-ionization; spectrometry