title: Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats.
abstract: BACKGROUND
  Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection.
  
  
  RESULTS
  Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression.
  
  
  CONCLUSIONS
  These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.
authors.forename: Paweł M
authors.initials: PM
authors.lastname: Bęczkowski
authors.forename: Navapon
authors.initials: N
authors.lastname: Techakriengkrai
authors.forename: Nicola
authors.initials: N
authors.lastname: Logan
authors.forename: Elizabeth
authors.initials: E
authors.lastname: McMonagle
authors.forename: Annette
authors.initials: A
authors.lastname: Litster
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Willett
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Hosie
mesh_terms: D000818:Animals; D002415:Cats; D018450:Disease Progression; D016181:Feline Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000821:virology; D006023:Glycoproteins / Q000502:physiology; D006031:Glycosylation; D016089:Immunodeficiency Virus, Feline / Q000502:physiology*; D017434:Protein Structure, Tertiary; D053262:Receptors, OX40 / Q000737:chemistry / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000502:physiology; D056189:Viral Tropism
chemical_list: D006023:Glycoproteins; D053262:Receptors, OX40; D014759:Viral Envelope Proteins; C445079:envelope protein, Feline immunodeficiency virus