title: Polyuric kidneys and uveitis: an oculorenal syndrome.
abstract: BACKGROUND
  Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) is a diagnosis of exclusion based on the presence of uveitis and acute tubulointerstitial nephritis in the absence of other disease entities known to cause both of these disorders. The proximal tubule is frequently affected by this syndrome, resulting in a wide range of presentations that vary from proteinuria to full picture of Fanconi syndrome. However, distal tubular involvement is not common.
  
  
  METHODS
  A 32-year-old female patient presented with polyuria, polydipsia and painful red eyes. Her water deprivation test and desmopressin test results were consistent with nephrogenic diabetes insipidus. Her kidney biopsy showed acute tubulointerstitial nephritis. Her eye exam was consistent with uveitis. To our knowledge, this is the first reported case of nephrogenic diabetes insipidus due to tubulointerstitial nephritis and uveitis syndrome.
  
  
  CONCLUSIONS
  Tubulointerstitial nephritis and uveitis syndrome (TINU) syndrome can present with multiple renal tubular defects, including nephrogenic diabetes insipidus.
authors.affiliation: Department of Nephrology, College of Medicine, University of Arizona, Tucson, USA.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Kamel
authors.affiliation: Department of Nephrology, College of Medicine, University of Arizona, Tucson, USA.
authors.forename: Bijin
authors.initials: B
authors.lastname: Thajudeen
authors.affiliation: Department of Pathology, College of Medicine, University of Arizona, Tucson, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Bracamonte
authors.affiliation: Department of Nephrology, College of Medicine, University of Arizona, Tucson, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Sussman
authors.affiliation: Department of Nephrology, College of Medicine, University of Arizona, Tucson, USA.
authors.forename: Yeong-Hau H
authors.initials: YH
authors.lastname: Lien
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000209:etiology*; D007690:Polycystic Kidney Diseases / Q000150:complications* / Q000175:diagnosis; D014605:Uveitis / Q000175:diagnosis / Q000209:etiology*