title: Outcome of acute kidney injury in pediatric patients admitted to the intensive care unit.
abstract: BACKGROUND
  Acute kidney injury (AKI) is common in the pediatric intensive care unit (PICU). We aimed to describe the etiology, clinical features, and outcome of AKI in pediatric patients and to determine the predictors for initiation of renal replacement and mortality.
  
  
  METHODS
  A retrospective chart review was performed of the medical records for all patients who were admitted to the PICU at King Abdulaziz University Hospital between January 1 and December 31, 2011. The pediatric-modified RIFLE criteria were used to classify AKI.
  
  
  RESULTS
  We included 102 children with AKI, aged 4 - 60 months. Oliguria (61.5%, p < 0.0001) and hypervolemic signs (38.5%, p = 0.03) were more common among patients with RIFLE class failure. They also had the highest mortality (53.9%, p = 0.01). Oliguric patients were ~ 23 times more likely than their non-oliguric counterparts to be initiated on renal replacement therapy (RRT) (RR = 23.38, 95% CI: 3.07 - 178.16). Diuretic infusion was also a strong predictor for RRT initiation (RR = 10.00, 95% CI: 2.77 - 36.12). Hypervolemic patients were twice more likely to die during hospitalization in both unadjusted and adjusted models (RR = 2.06, 95% CI: 1.09 - 3.90, and aRR = 2.45, 95% CI: 1.09 - 5.51, respectively). Mechanical ventilation and RRT initiation were associated with higher likelihood of death (ARR = 13.23, 95% CI: 1.90 - 92.04, and ARR = 2.20, 95% CI: 1.18 - 4.12, respectively). Patients with RIFLE class Failure were about thrice more likely than patients with RIFLE class Risk to die in both the unadjusted (RR = 2.76, 95% CI: 1.35 - 5.65), and adjusted models (ARR = 2.88, 95% CI: 1.38 - 6.04). Children with AKI had longer PICU stay (0.0003) and higher mortality (< 0.0001) than the non-AKI group.
  
  
  CONCLUSIONS
  Severe AKI predicted high mortality in critically ill children.
authors.affiliation: Pediatric Nephrology Unit, Intensive Care Unit, Department of Pediatrics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, Pediatric Nephrology Unit, Faculty of medicine, Cairo University, Cairo, Egypt, and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shalaby
authors.forename: Norah
authors.initials: N
authors.lastname: Khathlan
authors.forename: Osama
authors.initials: O
authors.lastname: Safder
authors.forename: Fatina
authors.initials: F
authors.lastname: Fadel
authors.forename: Youssef M K
authors.initials: YM
authors.lastname: Farag
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Singh
authors.forename: Jameela A
authors.initials: JA
authors.lastname: Kari
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000401:mortality; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006333:Heart Failure / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology; D007223:Infant; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D009846:Oliguria / Q000453:epidemiology; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D018805:Sepsis / Q000453:epidemiology
chemical_list: D004232:Diuretics