title: Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome.
abstract: OBJECTIVE
  The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This was a retrospective study.
  
  
  METHODS
  Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated.
  
  
  METHODS
  Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated.
  
  
  RESULTS
  Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The adiponectin to leptin ratios were significantly lower in PCOS women than in those without PCOS. Compared to women with non-PCOS, overweight/obese women with PCOS had lower serum adiponectin levels than women without PCOS, which was not the case for lean women. Conversely, lean women with PCOS had higher serum leptin levels than those without PCOS, which was not the case for overweight/obese women.
  
  
  CONCLUSIONS
  Adipose tissue might play an important role in the metabolic complications in women with PCOS. To study the impact of obesity biomarkers in women with PCOS, overweight/obese and lean women should be considered separately.
authors.affiliation: Department of Neurology and.
authors.forename: Chin-I
authors.initials: CI
authors.lastname: Chen
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Hsu
authors.forename: Shyh-Hsiang
authors.initials: SH
authors.lastname: Lin
authors.forename: Yuan-Chin I
authors.initials: YC
authors.lastname: Chang
authors.forename: Chun-Sen
authors.initials: CS
authors.lastname: Hsu
authors.forename: Chii-Ruey
authors.initials: CR
authors.lastname: Tzeng
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015536:Down-Regulation; D005260:Female; D044882:Glucose Metabolism Disorders / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D006786:Hospitals, Urban; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008499:Medical Records; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000378:metabolism; D012189:Retrospective Studies; D012306:Risk; D013624:Taiwan / Q000453:epidemiology; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: Adiponectin; PCOS; insulin resistance; leptin; obesity