title: Implications of CISNET modeling on number needed to screen and mortality reduction with digital mammography in women 40-49 years old.
abstract: OBJECTIVE
  In this article, we evaluate the implications of recent Cancer Intervention and Surveillance Modeling Network (CISNET) modeling of benefits and harms of screening to women 40-49 years old using annual digital mammography.
  
  
  CONCLUSIONS
  We show that adding annual digital mammography of women 40-49 years old to biennial screening of women 50-74 years old increases lives saved by 27% and life-years gained by 47%. Annual digital mammography in women 40-49 years old saves 42% more lives and life-years than biennial digital mammography. The number needed to screen to save one life (NNS) with annual digital mammography in women 40-49 years old is 588.
authors.affiliation: 1 Department of Radiology, University of Colorado - Denver, School of Medicine, 12700 E. 19th Ave, Mail Stop C278, Aurora, CO 80045.
authors.forename: R Edward
authors.initials: RE
authors.lastname: Hendrick
authors.forename: Mark A
authors.initials: MA
authors.lastname: Helvie
authors.forename: Lara A
authors.initials: LA
authors.lastname: Hardesty
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality*; D003198:Computer Simulation; D018572:Disease-Free Survival; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D008327:Mammography / Q000706:statistics & numerical data*; D008875:Middle Aged; D015233:Models, Statistical; D011159:Population Surveillance / Q000379:methods; D016016:Proportional Hazards Models; D011856:Radiographic Image Enhancement; D018570:Risk Assessment; D015996:Survival Rate; D014481:United States / Q000453:epidemiology
keywords: breast cancer; breast imaging; screening; technology; utilization