title: An efficient route to highly enantioenriched tetrahydroazulenes and β-tetralones by desymmetrization reactions of δ,δ-diaryldiazoaceto-acetates.
abstract: A highly stereoselective desymmetrization reaction of δ,δ-diaryl-α-diazo-β-ketoesters catalyzed by chiral dirhodium carboxylates forms aromatic cycloaddition products in up to 97% ee.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA. mdoyle3@umd.edu.
authors.forename: Yuxiao
authors.initials: Y
authors.lastname: Liu
authors.forename: Yongming
authors.initials: Y
authors.lastname: Deng
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: Renhua
authors.initials: R
authors.lastname: Liu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000143:Acids / Q000737:chemistry; D052176:Azulenes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D044024:Tetralones / Q000737:chemistry*
chemical_list: D000085:Acetates; D000143:Acids; D052176:Azulenes; D044024:Tetralones; C009423:beta-tetralone; C005525:azulene