title: Amyloid burden in cognitively normal elderly is associated with preferential hippocampal subfield volume loss.
abstract: The earliest sites of brain atrophy in Alzheimer's disease are in the medial temporal lobe, following widespread cerebral cortical amyloid deposition. We assessed 74 cognitively normal participants with clinical measurements, amyloid-β-PET imaging, MRI, and a newly developed technique for MRI-based hippocampal subfield segmentation to determine the differential association of amyloid deposition and hippocampal subfield volume. Compared to amyloid-negative participants, amyloid-positive participants had significantly smaller hippocampal tail, presubiculum, subiculum, and total hippocampal gray matter volumes. We conclude that, prior to the development of cognitive impairment, atrophy in particular hippocampal subfields occurs preferentially with amyloid-β accumulation.
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Hsu
authors.affiliation: Departments of Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
authors.forename: Haochang
authors.initials: H
authors.lastname: Shou
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Tammie
authors.initials: T
authors.lastname: Benzinger
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Marcus
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Durbin
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA Departments of Radiology, Neurology, and Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
authors.forename: Yvette I
authors.initials: YI
authors.lastname: Sheline
mesh_terms: D000368:Aged; D058227:Amyloidogenic Proteins / Q000378:metabolism*; D000814:Aniline Compounds; D003072:Cognition Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D058227:Amyloidogenic Proteins; D000814:Aniline Compounds; D013844:Thiazoles
keywords: Amyloid accumulation; cognitively normal elderly; hippocampal subfield volumes; presubiculum; subiculum