title: Late onset warfarin-induced skin necrosis.
abstract: The incidence of warfarin-induced skin necrosis (WISN) is rare. The majority of WISN cases usually appear between 3 and 6 days after the initiation of warfarin therapy. Here we report a late-onset case of WISN that occurred in a 52-year-old man 4 years after the initiation of therapy. The skin lesions in the patient were associated with acquired deficiency of protein C and protein S and abnormal liver function.
authors.affiliation: Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Chongmei
authors.initials: C
authors.lastname: Xin
authors.affiliation: Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China - xin.chongmei@zs-hospital.sh.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications / Q000175:diagnosis; D013997:Time Factors; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin