title: Chemerin serum levels in girls with anorexia nervosa.
abstract: BACKGROUND
  The regulatory function of chemerin (CHEM) in the process of adipogenesis and the metabolism of adipocytes has been confirmed. Data from several studies have shown higher serum CHEM in obesity. To date, there are no available studies on serum CHEM concentrations in patients with anorexia nervosa (AN), which is recognized as a good biological model of the chronic atrophy of adipose tissue and energy metabolism disorders in humans.
  
  
  OBJECTIVE
  The aim of the study was to assess serum CHEM concentrations in girls with AN in comparison to healthy and obese subjects and determine its relationship with body mass, BMI and insulin.
  
  
  METHODS
  CHEM serum concentrations were evaluated using commercially available ELISA kit in 65 Polish girls with restrictive AN, in 39 healthy controls (H) and 64 girls with simple obesity (OB).
  
  
  RESULTS
  The mean serum CHEM concentration in the AN group was significantly lower than in the H and OB groups. After adjusting for BMI, CHEM concentrations in the AN group were significantly lower than in the H group, but statistically higher than in the OB group. Significant correlations between serum CHEM and body mass (r=0.77), BMI (r=0.82), Cole index (r=0.81) and serum insulin (r=0.78) were observed.
authors.affiliation: Department of Pediatrics, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Oświecimska
authors.affiliation: Department of Pediatrics, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Katarzyna T
authors.initials: KT
authors.lastname: Ziora
authors.affiliation: Anmedis, Warszawa, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Suwała
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Swietochowska
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Gorczyca
authors.affiliation: Department of Genetics, Institute of Psychiatry and Neurology, Warszawa, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Ziora-Jakutowicz
authors.affiliation: Department of Pediatrics, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Machura
authors.affiliation: Department of Pediatrics, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepańska
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.affiliation: Department of Pneumonology and Tuberculosis, Medical University of Silesia, Zabrze, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
authors.affiliation: Clinic of Endocrinology and Diabetology Children's Memorial Health Institute in Warsaw, Poland.
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Szalecki
authors.affiliation: Department of Pediatrics, Faculty of Medicine and Division of Medical Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stojewska
authors.affiliation: Department of Pediatrics, Pediatric Endocrinology and Diabetes, Faculty of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Matusik
authors.affiliation: Department of Pediatrics, Pediatric Endocrinology and Diabetes, Faculty of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Małecka-Tendera
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood*; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D018925:Chemokines / Q000097:blood*; D002648:Child; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009752:Nutritional Status / Q000502:physiology; D009765:Obesity / Q000097:blood
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human