title: Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite).
abstract: We present a case report of a 41-year-old woman of Malay ethnicity who presented with an 11-day history of fever and left-sided lymphadenopathy after consuming 'Miracle Mineral Solution' (sodium chlorite solution) for the first time. A diagnosis of Kikuchi-Fujimoto disease was established via lymph node biopsy after other differentials were excluded. The aetiology of Kikuchi-Fujimoto disease remains controversial, but viral, autoimmune and physicochemical causes have been suggested as possibilities. In this case, we hypothesise that oxidative injury from sodium chlorite initiated an inflammatory response, which triggered the onset of Kikuchi-Fujimoto disease.
authors.affiliation: Department of General Medicine, Changi General Hospital, Singapore, Singapore.
authors.forename: John Ming Ren
authors.identifier: http://orcid.org/0000-0003-3228-2738
authors.initials: JM
authors.lastname: Loh
authors.affiliation: Department of General Medicine, Changi General Hospital, Singapore, Singapore.
authors.forename: Humaira
authors.initials: H
authors.lastname: Shafi
mesh_terms: D000328:Adult; D002712:Chlorides / Q000009:adverse effects*; D000529:Complementary Therapies / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D007413:Intestinal Mucosa / Q000473:pathology; D009960:Oropharynx / Q000473:pathology; D012996:Solutions
chemical_list: D002712:Chlorides; D012996:Solutions; C001599:chlorite