title: Synthesis of 3,3-dichloroindolin-2-ones from isatin-3-hydrazones and (dichloroiodo)benzene.
abstract: Aryl- and N-substituted isatins were converted to isatin-3-hydrazones and subjected to a dichlorination reaction with PhICl2. Lewis base-catalysis was key to the reaction occurring rapidly and chemoselectively, providing 3,3-dichloroindolin-2-ones in 49-99% yield, and offering a new approach to the deoxygenative dihalogenation reaction.
authors.affiliation: Department of Chemistry, University of Waterloo, 200 University Ave W., Waterloo, ON, CanadaN2L3G1. graham.murphy@uwaterloo.ca.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Coffey
authors.forename: Ryan
authors.initials: R
authors.lastname: Moreira
authors.forename: Farhana Z
authors.initials: FZ
authors.lastname: Abbas
authors.forename: Graham K
authors.initials: GK
authors.lastname: Murphy