title: [Is gluten the great etiopathogenic agent of disease in the XXI century?].
abstract: BACKGROUND
  Gluten is a glycoprotein present in some cereals. The incidence of disorders related to gluten, including the EC, is increasing, even pathologies far from an etiology or treatment with GF D.
  
  
  OBJECTIVE
  Review the scientific literature related to the ingestion of gluten and pathogenesis of different diseases.
  
  
  METHODS
  A literature search in major scientific database.
  
  
  RESULTS
  We obtained from the following diseases, gluten ataxia, multiple sclerosis, autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder, depressive disorders, headaches, irritable bowel syndrome, fibromyalgia, dermatitis herpetiformis and epilepsy, studies in which either a determination of gliadin was refered or a treatment, with/without gluten, was applied and evaluated.
  
  
  CONCLUSIONS
  The ingestion of gluten seems to be related to disease, when there is no EC, SGNC or wheat allergy. Suspicions about the benefit of GF D as a complementary treatment is borne in semi-clinical trials and cohorts, either as a causal factor in the pathogenesis, or improvement of symptoms.
authors.affiliation: Departamento de Medicina, Universidad Complutense de Madrid. España.. ismasmm@gmail.com.
authors.forename: Ismael
authors.initials: I
authors.lastname: San Mauro Martín
authors.affiliation: Centros de Investigación en Nutrición y Salud. Departamento de Medicina, Universidad Complutense de Madrid. España.. ismasmm@gmail.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Garicano Vilar
authors.affiliation: Centros de Investigación en Nutrición y Salud.. ismasmm@gmail.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Collado Yurrutia
authors.affiliation: Departamento de Medicina, Universidad Complutense de Madrid. España.. ismasmm@gmail.com.
authors.forename: María José
authors.initials: MJ
authors.lastname: Ciudad Cabañas
mesh_terms: D002446:Celiac Disease / Q000178:diet therapy; D055050:Diet, Gluten-Free; D005983:Glutens / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans
chemical_list: D005983:Glutens