title: The immunosuppressive effect of Siglecs on tendon-bone healing after ACL reconstruction.
abstract: The quality of the bone-tendon healing is very important to the surgery outcome after anterior cruciate ligament reconstruction. The necrosis of autograft and local new blood vessels occur after the surgery. The fibroblasts and mesenchymal cells presenting in the tendon-bone interface as well as the infiltrated of neutrophils and macrophages improve the biomechanical properties of the healing. We hypothesize that immunosuppressive effect of Siglecs which present on the surface of neutrophils and macrophages play the important roles to regulate acute local inflammatory reaction, maintain the physiological environment and induce the differentiation of the pluripotent cells to form the accepted histologic structure healing of the tendon-bone interface. It might be helpful to understand the mechanism of tendon-bone healing.
authors.affiliation: Department of Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Histology and Embryology, West China School of Preclinical and Forensic Institute, Sichuan University, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Histology and Embryology, West China School of Preclinical and Forensic Institute, Sichuan University, China; Sichuan University - Hong Kong Chinese University Reproductive Medicine Lab, West China Second University Hospital, Sichuan University, China. Electronic address: mafangmed@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
mesh_terms: D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods* / Q000534:rehabilitation; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000276:immunology / Q000494:pharmacology*; D013710:Tendons / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D007166:Immunosuppressive Agents; D063265:Sialic Acid Binding Immunoglobulin-like Lectins