title: Correlation of advanced glycation endproducts estimated from skin fluorescence in first-degree relatives: the impact of adjustment for skin pigmentation.
abstract: The objective was to assess the relationship of skin advanced glycation endproducts (AGEs) between first-degree relatives estimated from skin fluorescence (SF) after adjustment for skin pigmentation. SF was excited by LEDs centered at 375, 405, and 420 nm from children with type 1 diabetes and their mothers. Data were adjusted to generate measures of skin intrinsic fluorescence (SIF) at the various excitation wavelengths, using 2 different pairs of correction coefficients for excitation (kx) and emission (km): kx = 0.5, km = 0.5 (not associated with skin pigmentation) and kx = 1.0, km = 0.0 (strongly associated with skin pigmentation). Pearson correlation analysis was performed, as well as a multiple variable analysis with maternal SIF adjusted for the effects of maternal age and race. There were 50 matched pairs of children and their mothers. Children were 13.3 ± 3.7 years of age and there were 19 boys/31 girls and 15 black/35 white. Mothers were 41.8 ± 6.8 years of age. The age of mother and child was highly correlated, r = .64, P < .0001. In Pearson correlation analysis, child's SIF (kx = 1.0, km = 0.0) the had strongest association with maternal SIF, while with SIF (kx = 0.5, km = 0.5) there was a trend for association. In the multiple variable model child SIF was associated with maternal SIF for all corrections and wavelengths but was stronger for kx = 1.0, km = 0.0. Even after adjustment for skin pigmentation and race, correlation of SIF between family members persists, suggesting that other genetic and/or environmental factors shared by parent and child may influence estimated skin AGEs.
authors.affiliation: Pediatric Endocrinology/Diabetes, LSU-Health Sciences Center, Research Institute for Children, New Orleans, LA, USA.
authors.forename: Eileen A
authors.initials: EA
authors.lastname: Báez
authors.affiliation: Pediatric Endocrinology/Diabetes, LSU-Health Sciences Center, Research Institute for Children, New Orleans, LA, USA.
authors.forename: Shreepal
authors.initials: S
authors.lastname: Shah
authors.affiliation: Pediatric Endocrinology/Diabetes, LSU-Health Sciences Center, Research Institute for Children, New Orleans, LA, USA.
authors.forename: Dania
authors.initials: D
authors.lastname: Felipe
authors.affiliation: VeraLight, Inc, Albuquerque, NM, USA.
authors.forename: John
authors.initials: J
authors.lastname: Maynard
authors.affiliation: Pediatric Endocrinology/Diabetes, LSU-Health Sciences Center, Research Institute for Children, New Orleans, LA, USA schale@lsuhsc.edu.
authors.forename: Stuart
authors.initials: S
authors.lastname: Chalew
mesh_terms: D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D017127:Glycation End Products, Advanced / Q000032:analysis*; D006801:Humans; D009035:Mothers; D012880:Skin Pigmentation / Q000502:physiology*; D013050:Spectrometry, Fluorescence
chemical_list: D017127:Glycation End Products, Advanced
keywords: advanced glycation endproducts; intrinsic fluorescence; skin fluorescence; type 1 diabetes