title: COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case-control study.
abstract: BACKGROUND
  Depression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. The aim of this study is to determine association between COPD Assessment Test (CAT) and major depression among clinically stable out-patient COPD subjects with mild hypoxemia.
  
  
  METHODS
  Case-control study. Cases were 30 patients with major depression and controls were 30 patients without depression. Major depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders criteria by a psychiatric evaluation. All possible predictive variables were included in a multivariate logistic regression model to assess the association between major depression and each independent variable, while controlling for the sleep parameters.
  
  
  RESULTS
  CAT score >20 was associated with major depression (OR 7.88; 95% CI 1.96 - 31.7; p = 0.004).
  
  
  CONCLUSIONS
  CAT score >20 was associated with major depression, suggesting CAT as a predictor variable of major depression among COPD patients with mild hypoxemia, and indicating that an additional specific evaluation for the presence of major depression should be done.
authors.affiliation: Faculdade de Medicina da Universidade Federal de Goias/UFG, Goiania, Brazil. joselaertejr@gmail.com.
authors.forename: José Laerte R
authors.initials: JL
authors.lastname: Silva Júnior
authors.forename: Marcus Barreto
authors.initials: MB
authors.lastname: Conde
authors.forename: Krislainy
authors.initials: K
authors.lastname: de Sousa Corrêa
authors.forename: Christina
authors.initials: C
authors.lastname: da Silva
authors.forename: Leonardo
authors.initials: L
authors.lastname: da Silva Prestes
authors.forename: Marcelo Fouad
authors.initials: MF
authors.lastname: Rabahi
mesh_terms: D000368:Aged; D019540:Area Under Curve; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000209:etiology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D012372:ROC Curve; D012720:Severity of Illness Index; D014797:Vital Capacity