title: Bleeding complications after arthroscopy in a JAK2V617F-positive patient with essential thrombocythemia and acquired von Willebrand syndrome (AVWS).
abstract: Acquired von Willebrand syndrome (AVWS) is an acquired bleeding disorder with clinical and laboratory features similar to those of the inherited form of the disease. AVWS is reported in many disorders, most frequently in myeloproliferative neoplasms and in, among others, essential thrombocythemia (ET). Interestingly, ET is associated with both the thrombotic and haemorrhagic complications, which occur in 20 % and 5-30 % of patients, respectively. The present report concerns a 38-year-old man, suffering from ET, who presented with two episodes of post-arthroscopic joint bleeding after synovectomy required for the treatment of synovial hypertrophy and chronic left knee joint synovitis. We discuss the current diagnostic approaches, as well as the risk factors predisposing to bleeding and its management, in patients with essential thrombocythemia.
authors.affiliation: Department of Haematology, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569, Poznan, Poland, rupa.matysek@gmail.com.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rupa-Matysek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lewandowski
authors.forename: Maria
authors.initials: M
authors.lastname: Lewandowska
authors.forename: Ewelina
authors.initials: E
authors.lastname: Wojtasińska
authors.forename: Marzena Liliana
authors.initials: ML
authors.lastname: Wojtaszewska
authors.forename: Michał
authors.initials: M
authors.lastname: Walczak
authors.forename: Ksenia
authors.initials: K
authors.lastname: Bykowska
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Komarnicki
mesh_terms: D000328:Adult; D001182:Arthroscopy / Q000009:adverse effects*; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D007719:Knee Joint / Q000601:surgery; D008297:Male; D010976:Platelet Count; D017354:Point Mutation; D013585:Synovitis / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor; C507924:JAK2 protein, human; D053614:Janus Kinase 2