title: Oxygenation With a Single Portable Pulse-Dose Oxygen-Conserving Device and Combined Stationary and Portable Oxygen Delivery Devices in Subjects With COPD.
abstract: BACKGROUND
  Portable oxygen devices simplify and facilitate patient therapy. This study was designed to compare S(pO2) and patient satisfaction with a portable oxygen concentrator or a combined system consisting of a fixed device with continuous-flow oxygen dispensation and a portable device with pulse dispensation for ambulation.
  
  
  METHODS
  This crossover trial assessed 25 subjects with COPD (92% men, mean age of 72.2 ± 7.4 y, mean FEV1 of 34.14 ± 12.51% of predicted) at 4 hospitals in Madrid. All subjects had previously used the combined system, consisting of a fixed oxygenation system and a portable system for ambulation, with 16 (64%) using stationary and portable concentrators and 9 (36%) using a stationary reservoir and portable liquid oxygen bag. Oxygenation settings at rest and while walking were determined at baseline. Subjects were maintained on the previous combined system for 1 week and then switched to the portable oxygen concentrator for 1 week. Mean S(pO2) over 24 h was calculated using the software in the oximeter, and compliance was monitored (Visionox).
  
  
  RESULTS
  Low S(pO2) (< 90%) was significantly more frequent during use of the portable concentrator alone than with the combined system (37.1% vs 18.4%, P < .05). The portable system alone was preferred by 43% of subjects, and the combined system was preferred by 36%, whereas 21% were not sure.
  
  
  CONCLUSIONS
  Subjects preferred using a single portable oxygenation system both at home and during ambulation. Portable systems alone, however, did not supply the same levels of oxygenation as the combination of fixed and portable systems. Before the widespread adoption of portable systems as a single device, additional studies are needed to determine best-practice protocols for adjustment of daytime and nighttime oxygenation settings. (ClinicalTrials.gov registration NCT02079753).
authors.affiliation: Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain. ainam.yanez@ssib.es.
authors.forename: Aina M
authors.initials: AM
authors.lastname: Yáñez
authors.affiliation: Linde Healthcare (Linde Médica), Madrid, Spain.
authors.forename: Jose P
authors.initials: JP
authors.lastname: Prat
authors.affiliation: Servicio de Neumología, Hospital Clínico de San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Álvarez-Sala
authors.affiliation: Servicio de Neumología, Hospital Clínico de San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Myriam
authors.initials: M
authors.lastname: Calle
authors.affiliation: Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Díaz Lobato
authors.affiliation: Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: García Gonzalez
authors.affiliation: Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Rodríguez Gonzalez-Moro
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.
authors.forename: Raul
authors.initials: R
authors.lastname: Galera-Martínez
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Villasante
authors.affiliation: Linde Healthcare (Linde Médica), Madrid, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Ramos
authors.affiliation: Linde Healthcare (Linde Médica), Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Franco-Gay
authors.affiliation: Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: de Lucas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018592:Cross-Over Studies; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000295:instrumentation*; D010100:Oxygen / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation*; D017060:Patient Satisfaction; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*
chemical_list: D010100:Oxygen
keywords: COPD; ambulation; chronic respiratory failure; oxygen concentrator; oxygen sources; portable concentrator