title: Copper sulfide nanoparticles with phospholipid-PEG coating for in vivo near-infrared photothermal cancer therapy.
abstract: In this work, small sizes of hydrophobic copper sulfide nanoparticles (CuS NPs, ∼3.8 nm in diameter) have been successfully prepared from the reaction of copper chloride with sodium diethyldithiocarbamate (SDEDTC) inside a heated oleylamine solution. These CuS NPs displayed strong absorption in the 700-1100 nm near-infrared (NIR) region. By coating CuS NPs with DSPE-PEG2000 on the surface, the as-synthesized CuS@DSPE-PEG NPs exhibited good water solubility, significant stability and biocompatibility, as well as excellent photothermal conversion effects upon exposure to an 808 nm laser. After intravenous administration to mice, the CuS@DSPE-PEG NPs were found to passively target to the tumor site, and tumor tissues could be ablated efficiency under laser irradiation. In addition, CuS@DSPE-PEG NPs do not show significant toxicity by histological and blood chemistry analysis, and can be effectively excreted via metabolism. Our results indicated that CuS@DSPE-PEG NPs can act as an ideal photothermal agent for cancer photothermal therapy.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005 (P.R. China), Fax: (+86) 592-2183047.
authors.forename: Yizhuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Yulian
authors.initials: Y
authors.lastname: Lai
authors.forename: Saige
authors.initials: S
authors.lastname: Shi
authors.forename: Shufang
authors.initials: S
authors.lastname: Hao
authors.forename: Jingping
authors.initials: J
authors.lastname: Wei
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D006207:Half-Life; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: C519184:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); D010714:Phosphatidylethanolamines; D011092:Polyethylene Glycols; D003300:Copper; C017846:cupric sulfide
keywords: biodistribution; cancer; copper; nanoparticles; photothermal therapy; tumor ablation