title: Chronic consumption of trans fat can facilitate the development of hyperactive behavior in rats.
abstract: In recent decades, the increased consumption of processed foods, which are rich in hydrogenated vegetable fat (HVF), has led to a decreased consumption of fish and oilseed, rich in omega-3 fatty acids. This eating habit provides an increased intake of trans fatty acids (TFA), which may be related to neuropsychiatric conditions, including inattention and hyperactivity. In this study, we evaluated the potential connection between prolonged trans fat consumption and development of hyperactivity-like symptoms in rats using different behavioral paradigms. Trans fat intake for 10 months (Experiment 1), as well as during pregnancy and lactation across two sequential generations of rats, (Experiment 4) induced active coping in the forced swimming task (FST). In addition, HVF supplementation was associated with increased locomotion before and after amphetamine (AMPH) administration (Experiment 2). Similarly, HVF supplementation during pregnancy and lactation were associated with increased locomotion in both young and adult rats (Experiment 3). Furthermore, trans fat intake across two sequential generations increased locomotor and exploratory activities following stressors (Experiment 4). From these results, we suggest that chronic consumption of trans fat is able to enhance impulsiveness and reactivity to novelty, facilitating hyperactive behaviors.
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: Pase
authors.affiliation: Departamento de Fisiologia e Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: Kr
authors.initials: K
authors.lastname: Roversi
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Trevizol
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: F T
authors.initials: FT
authors.lastname: Kuhn
authors.affiliation: Departamento de Fisiologia e Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: V T
authors.initials: VT
authors.lastname: Dias
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: K
authors.initials: K
authors.lastname: Roversi
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: L T
authors.initials: LT
authors.lastname: Vey
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: C T
authors.initials: CT
authors.lastname: Antoniazzi
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.
authors.forename: R C S
authors.initials: RC
authors.lastname: Barcelos
authors.affiliation: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica-Universidade Federal de Santa Maria-UFSM-RS, Brazil. Electronic address: mariliseeb@yahoo.com.br.
authors.forename: M E
authors.initials: ME
authors.lastname: Bürger
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D017109:Akathisia, Drug-Induced / Q000503:physiopathology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004041:Dietary Fats / Q000633:toxicity*; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D007175:Impulsive Behavior / Q000502:physiology; D007774:Lactation; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010938:Plant Oils / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011595:Psychomotor Agitation / Q000209:etiology / Q000503:physiopathology*; D011897:Random Allocation; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology; D044242:Trans Fatty Acids / Q000633:toxicity*
chemical_list: D000697:Central Nervous System Stimulants; D004041:Dietary Fats; D010938:Plant Oils; D044242:Trans Fatty Acids; D000661:Amphetamine
keywords: Central nervous system; Forced swimming task; Hyperactivity; Open-field task; Trans fatty acids