title: Topical timolol maleate 0.5% for infantile hemangioma; it's effectiveness and/or adjunctive pulsed dye laser - single center experience of 102 cases in Korea.
abstract: Although oral beta-blocker, propranolol, was shown excellent outcome for infantile hemangioma (IH) up to date, concern of side effects and reluctance of treatment-related cumbersome evaluations are major obstacles to employ. Instead, topical beta-blockers were recently introduced as an effective alternative, but few studies are reported. So we performed a retrospective study of IH treated with topical beta-blockers, timolol maleate 0.5%, and adjunctive role of pulsed dye laser from 2011 to 2014. Among 102 IH enrolled, 61 patients (59.8%) treated with only timolol maleate and 41 (40.2%) patients treated with combination of pulsed dye laser. A clinical review of medical records and evaluation at 4-8 weeks intervals using the physicians' Global Assessment Scores (GAS) and patients' parents' GAS at the latest visit. Physicians' GAS was used to grade the lesions compared with the baseline photo by two physicians' evaluation. And parents' GAS was assessed by direct or telephone interview. In the only timolol treatment group, mean change was within 47.0% improvement from baseline by physicians. In addition, adjunctive treatment of pulsed dye laser group showed 66.5% improvement. No side effects were found on both groups, and mean change was 54.5% improvement by overall parent assessments.
authors.affiliation: Department of Dermatology and.
authors.forename: Kyung Hea
authors.initials: KH
authors.lastname: Park
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Jang
authors.forename: Ho Yun
authors.initials: HY
authors.lastname: Chung
authors.forename: Weon Ju
authors.initials: WJ
authors.lastname: Lee
authors.forename: Do Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Seok-Jong
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006391:Hemangioma / Q000628:therapy*; D006801:Humans; D007223:Infant; D054025:Lasers, Dye / Q000627:therapeutic use*; D008297:Male; D056910:Republic of Korea; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000628:therapy*; D013999:Timolol / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D013999:Timolol
keywords: Infantile hemangioma; timolol; topical propranolol