title: One-pot cascade synthesis of N-methoxyisoquinolinediones via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization.
abstract: Here a new, mild and versatile method for one-pot cascade synthesis of diverse N-methoxyisoquinolinediones via Rh(III)-catalyzed regioselective carbenoid insertion C-H activation/cyclization of N-methoxybenzamides with α-diazotized Meldrum's acid has been achieved. Extension of the developed Rh(III) catalysis for building new analogs of the marketed drug Edaravone has also been demonstrated.
authors.affiliation: VARI/SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China. yiwei.simm@simm.ac.cn eric.xu@simm.ac.cn.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Shi
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Yunnan
authors.initials: Y
authors.lastname: Yan
authors.forename: Jinlong
authors.initials: J
authors.lastname: Jia
authors.forename: Xuelei
authors.initials: X
authors.lastname: Liu
authors.forename: Huacan
authors.initials: H
authors.lastname: Song
authors.forename: H Eric
authors.initials: HE
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Yi
mesh_terms: D001549:Benzamides / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004146:Dioxanes / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001549:Benzamides; D004146:Dioxanes; D007546:Isoquinolines; C076489:Meldrum's acid; D012238:Rhodium; C025159:3-methoxybenzamide