title: Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations.
abstract: BACKGROUND
  Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism with lung cancer in Asian populations have provided inconclusive findings.
  
  
  OBJECTIVE
  A meta-analysis was performed to investigate a more reliable association between MTHFR C677T polymorphism and lung cancer in Asians.
  
  
  METHODS
  A comprehensive search was conducted to identify all case-control studies of MTHFR polymorphisms and lung cancer in Asia, using odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association.
  
  
  RESULTS
  Meta-analysis results suggested that the MTHFR C677T polymorphism contributed to an increased lung cancer risk in Asian populations (for T vs C: OR=1.11, 95%CI=1.0-1.23; for CT vs CC: OR= 1.1, 95%CI= 0.95-1.2 ; for TT+CT vs CC: OR=1.13, 95%CI=1.0-1.30; for TT vs CC: OR=1.25, 95%CI=1.01-1.30; for TT vs CT+CC: OR=1.16, 95%CI=1.0-1.36).
  
  
  CONCLUSIONS
  MTHFR C677T polymorphism is significantly associated with lung cancer in Asians.
authors.affiliation: Department of Biotechnology, Human Molecular Laboratory, VBS Purvanchal University, Jaunpur, India E-mail : raivandana@rediffmail.com.
authors.forename: Vandana
authors.initials: V
authors.lastname: Rai
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005492:Folic Acid / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics
chemical_list: D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)