title: A new bis-seco-abietane diterpenoid from Hyptis crenata Pohl ex Benth.
abstract: A new, highly oxidized, bis-seco-abietane diterpenoid named hyptisolide A (1) was isolated from Hyptis crenata Pohl ex Benth. Its structure and stereochemistry were elucidated on the basis of data obtained by HRESIMS, NMR, and X-ray diffraction analyses, and its absolute configuration was determined with vibrational circular dichroism spectroscopy. By reporter gene assay, 1 was demonstrated to induce cAMP-responsive element-dependent transcription in Neuro2A cells.
authors.affiliation: †School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Yun
authors.affiliation: †School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukaya
authors.affiliation: ‡Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Nakane
authors.affiliation: ‡Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Takano
authors.affiliation: †School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: †School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: †School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Inoue
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000378:metabolism; D031331:Hyptis / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D045784:Abietanes; D018696:Neuroprotective Agents; C000596644:hyptisolide A; D000242:Cyclic AMP