title: Clinical usefulness of dopamine transporter SPECT imaging with 123I-FP-CIT in patients with possible dementia with Lewy bodies: randomised study.
abstract: BACKGROUND
  Dementia with Lewy bodies (DLB) is underrecognised in clinical settings.
  
  
  OBJECTIVE
  To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia).
  
  
  METHODS
  We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB.
  
  
  RESULTS
  There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%).
  
  
  CONCLUSIONS
  Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB.
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Walker
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Moreno
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Alan
authors.initials: A
authors.lastname: Thomas
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Fraser
authors.initials: F
authors.lastname: Inglis
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Naji
authors.initials: N
authors.lastname: Tabet
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Michael
authors.initials: M
authors.lastname: Rainer
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Pizzolato
authors.affiliation: Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D009662:Nortropanes; D011237:Predictive Value of Tests; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D009662:Nortropanes; C519528:ioflupane