title: Importance of intestinal microenvironment in development of arthritis. A systematic review.
abstract: A strong connection between spondylarthropathies and inflammatory bowel diseases (IBD) is well established. About 10-15% of IBD are associated with different forms of spondylarthritis. Arthritis can be manifested as axial, peripheral form or both. The primary functions of the gastrointestinal tract are digestion and absorption of nutrients, electrocytes and maintenance of water homoeostasis. The anatomic and functional lesions could lead to the development of IBD based on molecular mimicry and bystander effects. The mechanism of the macromolecules is uptaken may affect intestinal and extraintestinal manifestation in genetically susceptible individuals by gut-associated lymphoid tissue, the interplay between innate and adaptive immunity and the neuroendocrine network.
authors.affiliation: National Institute of Rheumatology and Physiotherapy, Frankel L. u. 38-40., Budapest, Hungary, bazsoanna@yahoo.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Bazsó
authors.forename: Péter
authors.initials: P
authors.lastname: Szodoray
authors.forename: Gábor
authors.initials: G
authors.lastname: Sütő
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: Gyula
authors.initials: G
authors.lastname: Poór
authors.forename: Emese
authors.initials: E
authors.lastname: Kiss
mesh_terms: D056704:Adaptive Immunity; D001168:Arthritis / Q000209:etiology*; D060833:Cellular Microenvironment; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000150:complications; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D064307:Microbiota; D025242:Spondylarthropathies / Q000209:etiology