title: [Gastric cancer with liver metastasis and peritoneal dissemination treated with conversion surgery to achieve r0 resection after capecitabine, cisplatin, and trastuzumab chemotherapy-a case report].
abstract: Herein, we present a case report suggesting the importance of conversion surgery and the effectiveness of adjuvant chemotherapy with trastuzumab. A 77-year-old woman was diagnosed with gastric cancer complicated by multiple liver metastases and peritoneal dissemination. Owing to a HER2 immunohistochemistry (IHC) tumor score of 3+, we initiated capecitabine plus cisplatin (CDDP) plus trastuzumab chemotherapy. Subsequently, the liver metastases and peritoneal dissemination were absent on computed tomography images, and no new metastatic lesions developed during chemotherapy. After 10 chemotherapy courses, the patient underwent distal gastrectomy and 2 partial liver resection procedures. The liver metastasis remained, and it received a score of 2+ on the HER2 IHC test. We have continued to administer postoperative capecitabine plus trastuzumab chemotherapy because no metastatic lesions have appeared.
authors.affiliation: Dept. of Surgery, Hiroshima City Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Choda
authors.forename: Motoki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sato
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tokumoto
authors.forename: Masao
authors.initials: M
authors.lastname: Harano
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ojima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Idani
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Shiozaki
authors.forename: Masazumi
authors.initials: M
authors.lastname: Okajima
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069287:Capecitabine; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D005743:Gastrectomy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008207:Lymphatic Metastasis; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D003841:Deoxycytidine; D000069287:Capecitabine; D000068878:Trastuzumab; D002945:Cisplatin; D005472:Fluorouracil