title: Serum wnt5a is a predictor for the prognosis of acute on chronic hepatitis B liver failure.
abstract: OBJECTIVE
  To find a biomarker to predict the prognosis of acute on chronic hepatitis B liver failure (ACHBLF).
  
  
  METHODS
  Expression gene profiles in wnt pathway were determined in serum from 63 patients with ACHBLF, 60 patients with chronic hepatitis B (CHB) and 30 healthy controls (HCs).
  
  
  RESULTS
  Serum wnt5a concentration of 1.553 ng/ml showed a poor prognosis with a sensitivity of 69.23% and a specificity of 83.33% in ACHBLF patients.
  
  
  CONCLUSIONS
  Serum wnt5a gene expression might be a potential biomarker for predicting the prognosis of ACHBLF.
authors.affiliation: Department of Hepatology, Qilu Hospital of Shandong University , Jinan , China and.
authors.forename: Xiang-Fen
authors.initials: XF
authors.lastname: Ji
authors.forename: Xin-You
authors.initials: XY
authors.lastname: Li
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Fan
authors.forename: Ze-Hua
authors.initials: ZH
authors.lastname: Zhao
authors.forename: Shuai
authors.initials: S
authors.lastname: Gao
authors.forename: Feng-Kai
authors.initials: FK
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000097:blood* / Q000401:mortality / Q000821:virology; D000328:Adult; D016022:Case-Control Studies; D019175:DNA Methylation; D005260:Female; D015870:Gene Expression; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000401:mortality; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D011379:Prognosis; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000235:genetics; D012372:ROC Curve; D051153:Wnt Proteins / Q000097:blood* / Q000235:genetics; D000071818:Wnt-5a Protein; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins; C085389:WNT5A protein, human
keywords: acute on chronic hepatitis B liver failure; prognosis; sfrp1; wnt5a