title: Effects of particulate air pollution on nasal and lung function development among Greek children: a 19-year cohort study.
abstract: The aim was to investigate respiratory symptoms, lung function and nasal airflow development among a cohort of children who were exposed to particulate air pollution. We used questionnaires, spirometry and rhinomanometry, while central-monitored PM10 concentrations were used for exposure assessment. We initially examined 1046 children (10-12 year old) in the heavily polluted town of Ptolemaida, Greece, and 379 children in the cleaner town of Grevena (control group). We re-evaluated 312 of the former and 119 of the latter after 19 years. PM10 concentrations were above permissible levels in Ptolemaida during all study period. At both visits, nasal flow was significantly lower in the study sample. At the follow-up visit, 34.3% had severe nasal obstruction (< 500 ml/s) and 38.5% reported chronic nasal symptoms. Spirometric parameters did not differ compared to the control group. Particulate air pollution had significant and negative effects on nasal but not on lung function development.
authors.affiliation: a Laboratory for the Investigation of Environmental Diseases, Pulmonary Department , Aristotle University of Thessaloniki , Thessaloniki , Greece.
authors.forename: Dionisios
authors.initials: D
authors.lastname: Spyratos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Sioutas
authors.forename: Anastasios
authors.initials: A
authors.lastname: Tsiotsios
authors.forename: Anna-Bettina
authors.initials: AB
authors.lastname: Haidich
authors.forename: Diamantis
authors.initials: D
authors.lastname: Chloros
authors.forename: Georgios
authors.initials: G
authors.lastname: Triantafyllou
authors.forename: Lazaros
authors.initials: L
authors.lastname: Sichletidis
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D002648:Child; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005500:Follow-Up Studies; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D052638:Particulate Matter / Q000032:analysis*; D011446:Prospective Studies; D012119:Respiration; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: air pollution; children; prospective study; rhinomanometry; spirometry