title: Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517-sorbic acid cocrystal production.
abstract: The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517-sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate and screw speed were investigated. Extent of conversion to the cocrystal was found to have a strong dependence on temperature and a moderate dependence on feed rate and screw speed. Cocrystals made by the TSE process were found to have superior mechanical properties than solution grown cocrystals. Additionally, moving to a TSE process eliminated the need for solvent.
authors.affiliation: Amgen Inc., Small Molecule Process & Product Development, Thousand Oaks, California, USA.
authors.forename: Dominick
authors.initials: D
authors.lastname: Daurio
authors.forename: Karthik
authors.initials: K
authors.lastname: Nagapudi
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Peter
authors.initials: P
authors.lastname: Quan
authors.forename: Fernando-Alvarez
authors.initials: FA
authors.lastname: Nunez
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry*; D003460:Crystallization; D004355:Drug Stability; D011743:Pyrimidines / Q000737:chemistry*; D013011:Sorbic Acid / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; C523409:N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide; D011743:Pyrimidines; D013011:Sorbic Acid