title: Proatherogenic oxidized low-density lipoprotein/β2-glycoprotein I complexes in arterial and venous disease.
abstract: OxLDL/β2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes. We investigate the significance of anti-oxLDL/β2GPI antibodies and oxLDL/β2GPI complexes in patients with arterial and idiopathic venous disease. A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied. Because statins influence oxLDL/β2GPI, these complexes were analyzed on subjects not taking statins. Arterial and venous groups expressed higher levels of IgG anti-oxLDL/β2GPI antibodies than controls without any other significant clinical association. OxLDL/β2GPI complexes were significantly elevated in arterial (0.69 U/mL, P = 0.004) and venous disease (0.54 U/mL, P = 0.025) than controls (0.39 U/mL). Among arterial diseases, oxLDL/β2GPI was 0.85 U/mL for carotid artery disease, 0.72 U/mL for peripheral artery disease, and 0.52 U/mL for abdominal aortic aneurysm. There was a significant association with male gender, age, hypertension, and history of thrombosis. Subjects with oxLDL/β2GPI above the median (0.25 U/mL) were more likely to have arterial (OR 4.5, P = 0.004) or venous disease (OR 4.1, P = 0.008). Multivariate regression indicated that males (P = 0.021), high cholesterol (P = 0.011), and carotid disease (P = 0.023) were significant predictors of oxLDL/β2GPI. The coexistence of oxLDL/β2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.
authors.affiliation: Department of Medicine, Divisions of Cardiology and Hematology, New York University School of Medicine, New York, NY 10016, USA ; Department of Surgery, Division of Vascular Surgery, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Berger
authors.affiliation: Department of Surgery, Division of Vascular Surgery, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Caron B
authors.initials: CB
authors.lastname: Rockman
authors.affiliation: Department of Chemistry, Indiana University, South Bend, IN 46634, USA.
authors.forename: Kirk E
authors.initials: KE
authors.lastname: Guyer
authors.affiliation: Medical Department, Corgenix, Inc., 11575 Main Street, No. 400, Broomfield, CO 80020, USA.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000276:immunology / Q000378:metabolism; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000276:immunology / Q000378:metabolism; D002784:Cholesterol / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D046912:Multiprotein Complexes / Q000276:immunology* / Q000378:metabolism; D015999:Multivariate Analysis; D058729:Peripheral Arterial Disease / Q000276:immunology / Q000378:metabolism; D011379:Prognosis; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D014652:Vascular Diseases / Q000276:immunology* / Q000378:metabolism; D053482:beta 2-Glycoprotein I / Q000276:immunology* / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D046912:Multiprotein Complexes; D053482:beta 2-Glycoprotein I; C099252:oxidized low density lipoprotein; D002784:Cholesterol