title: Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.
abstract: Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from oleoresin of Pinus longifolia Roxberghii.
authors.affiliation: Bilkent University, BilGen Genetics and Biotechnology Research Centre, Turkey / Department of Molecular Biology and Genetics, Ankara, Turkey / Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
authors.forename: Muhammad Ayaz
authors.initials: MA
authors.lastname: Mustufa
authors.affiliation: Depatment of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Afshan
authors.initials: A
authors.lastname: Aslam
authors.affiliation: Bilkent University, BilGen Genetics and Biotechnology Research Centre, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Ozen
authors.affiliation: Depatment of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Imran Ali
authors.initials: IA
authors.lastname: Hashmi
authors.affiliation: Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
authors.forename: Naimul Hasan
authors.initials: NH
authors.lastname: Naqvi
authors.affiliation: Bilkent University, BilGen Genetics and Biotechnology Research Centre, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozturk
authors.affiliation: Depatment of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Firdous Imran
authors.initials: FI
authors.lastname: Ali
mesh_terms: D045784:Abietanes / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D061986:MCF-7 Cells
chemical_list: D045784:Abietanes; D005227:Fatty Acids; C026490:abietyl alcohol