title: Nanomaterials, inflammation, and tissue engineering.
abstract: Nanomaterials exhibit unique properties that are absent in the bulk material because decreasing material size leads to an exponential increase in surface area, surface area to volume ratio, and effective stiffness, resulting in altered physiochemical properties. Diverse categories of nanomaterials such as nanoparticles, nanoporous scaffolds, nanopatterned surfaces, nanofibers, and carbon nanotubes can be generated using advanced fabrication and processing techniques. These materials are being increasingly incorporated in tissue engineering scaffolds to facilitate the development of biomimetic substitutes to replace damaged tissues and organs. Long-term success of nanomaterials in tissue engineering is contingent upon the inflammatory responses they elicit in vivo. This review seeks to summarize the recent developments in our understanding of biochemical and biophysical attributes of nanomaterials and the inflammatory responses they elicit, with a focus on strategies for nanomaterial design in tissue engineering applications.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Center for Research on Interface Structures and Phenomena, Yale University, New Haven, CT, USA.
authors.forename: Jagannath
authors.initials: J
authors.lastname: Padmanabhan
authors.forename: Themis R
authors.initials: TR
authors.lastname: Kyriakides
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry; D019317:Evidence-Based Medicine; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000276:immunology*; D049329:Nanostructures / Q000009:adverse effects* / Q000737:chemistry; D018570:Risk Assessment; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials