title: Overview of automated immunohistochemistry.
abstract: BACKGROUND
  The increasing demand for immunohistochemistry for clinical diagnostics, in combination with an ongoing shortage of staff in the histology laboratory, has brought about a need for automation in immunohistochemistry. The current automated staining platforms vary significantly in their design and capabilities.
  
  
  OBJECTIVE
  To review how technology has been applied to automating the process of immunohistochemical staining.
  
  
  METHODS
  Literature review, vendor interviews, and personal practice experience.
  
  
  CONCLUSIONS
  Each of the commercially available, automated immunohistochemistry platforms has strategic design differences that produce advantages and disadvantages. Understanding those differences can help match the demands of testing volumes, turnaround time, standardization, and labor savings to the appropriate automated instrumentation.
authors.affiliation: From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Prichard
mesh_terms: D057205:Automation, Laboratory / Q000379:methods* / Q000592:standards; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods* / Q000592:standards