title: Clinical presentation and management of stable coronary artery disease: insights from the international prospective CLARIFY registry - results from the Greek national cohort.
abstract: BACKGROUND
  Coronary artery disease (CAD) is highly prevalent worldwide, yet there is a paucity of data regarding the clinical characteristics and management of outpatients with stable CAD. In this paper, we report the baseline data of the Greek cohort and we compare our national data with the global results of the entire registry, as well as the results from the western European countries.
  
  
  METHODS
  CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis >50%, or chest pain associated with proven myocardial ischemia. A total of 33,283 patients from 45 countries in 4 continents were enrolled between November 2009 and July 2010; of these, 14,726 were from western European countries (Austria, Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Netherlands, Portugal, Spain, Switzerland and the United Kingdom) and 559 patients were enrolled in Greece.
  
  
  RESULTS
  Compared to their counterparts in western Europe and the entire cohort, Greeks were younger (p<0.0001, p<0.0001, respectively), more predominantly male (p<0.0039, p<0.0001), with a higher body mass index (p<0.0002, p<0.0001) and a larger waist circumference (p<0.0001, p<0.0001), as well as a higher prevalence of family history of CAD (p<0.0008, 0.0005), hyperlipidemia (p<0.0001, p<0.0001) and smoking (p<0.0001, p<0.0001). Noninvasive testing (p<0.0001, p<0.0001, respectively) and coronary angiography (p<0.0001, 0.0013) along with surgical revascularization (CABG) (p<0.0001, 0.0088) were performed more often in Greece. Antiplatelets, b-blockers and lipid lowering medications were used to an equal extent in Greece as in the other two cohorts.
  
  
  CONCLUSIONS
  There are substantial differences in demographics, clinical profiles and treatment in patients with stable CAD within the data set, which are also observed for Greek data. Interestingly, these differences are consistent in relation to the global as well as the western European data.
authors.affiliation: Second Division of Interventional Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Eftihia
authors.initials: E
authors.lastname: Sbarouni
authors.forename: Vassilis
authors.initials: V
authors.lastname: Voudris
authors.forename: Panagiota
authors.initials: P
authors.lastname: Georgiadou
authors.forename: Michalis
authors.initials: M
authors.lastname: Hamilos
authors.forename: P Gabriel
authors.initials: PG
authors.lastname: Steg
authors.forename: Kim M
authors.initials: KM
authors.lastname: Fox
authors.forename: Nicola
authors.initials: N
authors.lastname: Greenlaw
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.forename: Panos E
authors.initials: PE
authors.lastname: Vardas
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002317:Cardiovascular Agents / Q000627:therapeutic use; D017023:Coronary Angiography / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D019468:Disease Management; D005060:Europe; D005260:Female; D006115:Greece; D006334:Heart Function Tests; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods / Q000706:statistics & numerical data; D062072:Patient Acuity; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*
chemical_list: D002317:Cardiovascular Agents