title: Regioselective and Diastereoselective Aminoarylation of 1,3-Dienes.
abstract: The 1,4-functionalization of dienes is a synthetically useful strategy for incorporating molecular complexity into a class of simple substrates. We report the aminoarylation of acyclic and cyclic 1,3-dienes via the sequential [4+2] cycloaddition with a sulfurdiimide reagent and copper-catalyzed allylic substitution with Grignard reagents. The regioselective and diastereoselective aminoarylation of unsymmetrical dienes is also presented, which highlights the utility of this method for generating products with multiple functional groups and stereocenters.
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas, Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA. ; Tel: +1-214-648-0580.
authors.forename: Hongli
authors.initials: H
authors.lastname: Bao
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas, Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA. ; Tel: +1-214-648-0580.
authors.forename: Liela
authors.initials: L
authors.lastname: Bayeh
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas, Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA. ; Tel: +1-214-648-0580.
authors.forename: Uttam K
authors.initials: UK
authors.lastname: Tambar