title: Amperometric sensor based on a graphene/copper hexacyanoferrate nano-composite for highly sensitive electrocatalytic determination of captopril.
abstract: In this work, a bi-layer modified glassy carbon electrode (GCE) was prepared by depositing appropriate amounts of multilayered graphene (GR) on the surface of GCE, followed by electrodepositing copper hexacyanoferrate (CuHCF) nano-particles on the graphene layer. The combination of graphene and CuHCF considerably improved the current response of the GCE towards the oxidation of captopril. Studies showed that the best response of the modified electrode could be achieved within neutral pHs. At a fixed potential under hydrodynamic conditions (stirred solutions), the oxidation current is proportional to the captopril concentration and the calibration plots were linear over the concentration ranges of 0.2 to 5.8 μM and 5.8 to 480 μM. The detection limit of the method was 0.09 μM. The modified electrode was used for electrocatalytic determination of captopril in some real samples.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Electronic address: mbgholivand@yahoo.com.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Gholivand
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khodadadian
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Omidi
mesh_terms: D002216:Captopril / Q000032:analysis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D005295:Ferrocyanides / Q000737:chemistry*; D005898:Glass / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D013607:Tablets / Q000737:chemistry
chemical_list: D005295:Ferrocyanides; D013607:Tablets; C116383:ferrocyn; D006108:Graphite; D003300:Copper; D002216:Captopril