title: A promising road with challenges: where are gold nanoparticles in translational research?
abstract: Nanoenabled technology holds great potential for health issues and biological research. Among the numerous inorganic nanoparticles that are available today, gold nanoparticles are fully developed as therapeutic and diagnostic agents both in vitro and in vivo due to their physicochemical properties. Owing to this, substantial work has been conducted in terms of developing biosensors for noninvasive and targeted tumor diagnosis and treatment. Some studies have even expanded into clinical trials. This article focuses on the fundamentals and synthesis of gold nanoparticles, as well as the latest, most promising applications in cancer research, such as molecular diagnostics, immunosensors, surface-enhanced Raman spectroscopy and bioimaging. Challenges to their further translational development are also discussed.
authors.affiliation: Department of Instrument Science & Engineering, School of Electronic Information & Electrical Engineering, Research Institute of Translation Medicine, Shanghai Jiao Tong University, Dongchuan Road 800, 200240 Shanghai, People's Republic of China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Bao
authors.forename: João
authors.initials: J
authors.lastname: Conde
authors.forename: Ester
authors.initials: E
authors.lastname: Polo
authors.forename: Pablo
authors.initials: P
authors.lastname: del Pino
authors.forename: Maria
authors.initials: M
authors.lastname: Moros
authors.forename: Pedro V
authors.initials: PV
authors.lastname: Baptista
authors.forename: Valeria
authors.initials: V
authors.lastname: Grazu
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
authors.forename: Jesus M
authors.initials: JM
authors.lastname: de la Fuente
mesh_terms: D015374:Biosensing Techniques; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D057170:Translational Research, Biomedical
chemical_list: D006046:Gold
keywords: biomedical diagnostics; gold nanoparticles; nanomedicine; translational research