title: [Peripherally inserted central catheter antibiotic therapy for cystic fibrosis patients].
abstract: BACKGROUND
  Peripherally inserted central catheters (PICC) are more and more used for intravenous antibiotic infusions in cystic fibrosis (CF) patients in the Grenoble area (France). The aim of this study was to assess the use of this technique in this indication.
  
  
  METHODS
  1. Retrospective evaluation of 102 consecutive PICC insertions over 3years and the incidence of adverse events during the therapy. 2. Prospective evaluation of 12 patient's satisfaction and their nurses over a 3-month period. 3. Comparative analysis of single domiciliary treatment costs using PICC versus peripheral catheter (PC).
  
  
  RESULTS
  102 PICC insertions were attempted in 31 patients. Seven failures and 7 complications occurred during the treatment requiring removal of the PICC, i.e. an overall success rate of 86.2% (88/102). Pain during PICC introduction was 4.2/10 (visual analogical scale). Mean satisfaction levels during therapy were 9.3/10 for patients and 8.7/10 for nurses. Compared with PC, all the patients said that PICC was "more comfortable". Differential costs of treatment with PC and with PICC at home were estimated at 57.15€ and 590.16€ respectively.
  
  
  CONCLUSIONS
  PICC is an alternative to CP for intravenous antibiotherapy in CF patients, providing better safety and comfort. PICC use should be promoted in this indication.
authors.affiliation: Pôle pharmacie, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: A-L
authors.initials: AL
authors.lastname: Betegnie
authors.affiliation: CRCM adulte (centre de ressource et de compétence pour la mucoviscidose), pôle médecine aiguë communautaire, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France; Inserm CIC3, unité de pharmacologie clinique, centre d'investigation clinique, CHU de Grenoble, 38043 Grenoble cedex 09, France. Electronic address: CCracowski@chu-grenoble.fr.
authors.forename: C
authors.initials: C
authors.lastname: Cracowski
authors.affiliation: Pôle pharmacie, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France; UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525/Themas, 38041 Grenoble, France.
authors.forename: P
authors.initials: P
authors.lastname: Bedouch
authors.affiliation: CRCM adulte (centre de ressource et de compétence pour la mucoviscidose), pôle médecine aiguë communautaire, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: C
authors.initials: C
authors.lastname: Segond
authors.affiliation: Pôle pharmacie, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Robein-Dobremez
authors.affiliation: CRCM pédiatrique, pôle couple enfant, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.affiliation: Pôle pharmacie, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France; UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525/Themas, 38041 Grenoble, France.
authors.forename: B
authors.initials: B
authors.lastname: Allenet
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001291:Attitude of Health Personnel; D055499:Catheter-Related Infections / Q000453:epidemiology; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000379:methods* / Q000451:nursing; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000379:methods* / Q000451:nursing; D002408:Catheters, Indwelling / Q000009:adverse effects; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Anti-bacterial agents; Antibiotique; Catheter; Cathéter; Cystic fibrosis; Dispositif médical; Medical device; Mucoviscidose; Satisfaction