title: Predictors of satisfactory improvements in pain for patients with early rheumatoid arthritis in a treat-to-target study.
abstract: OBJECTIVE
  The aim of this study was to identify baseline predictors of achieving patient-perceived satisfactory improvement (PPSI) in pain after 6 months of treat to target in patients with early RA.
  
  
  METHODS
  Baseline and 6 month data were used from patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study. Simple and multivariable logistic regression analyses were used to identify significant predictors of achieving an absolute improvement of 30 mm or a relative improvement of 50% on a visual analogue scale for pain.
  
  
  RESULTS
  At 6 months, 125 of 209 patients (59.8%) achieved an absolute PPSI and 130 patients (62.2%) achieved a relative PPSI in pain. Controlling for baseline pain, having symmetrical arthritis was the strongest independent predictor of achieving an absolute [odds ratio (OR) 3.17, P = 0.03] or relative (OR 3.44, P = 0.01) PPSI. Additionally, anti-CCP positivity (OR 2.04, P = 0.04) and having ≤12 tender joints (OR 0.29, P = 0.01) were predictive of achieving a relative PPSI. The total explained variance of baseline predictors was 30% for absolute and 18% for relative improvements, respectively.
  
  
  CONCLUSIONS
  Symmetrical joint involvement, anti-CCP positivity and fewer tender joints at baseline are prognostic signs for achieving satisfactory improvement in pain after 6 months of treat to target in patients with early RA.
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands. P.M.tenKlooster@utwente.nl.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Ten Klooster
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands. Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Harald E
authors.initials: HE
authors.lastname: Vonkeman
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Martijn A H
authors.initials: MA
authors.lastname: Oude Voshaar
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Liseth
authors.initials: L
authors.lastname: Siemons
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Piet L C M
authors.initials: PL
authors.lastname: van Riel
authors.affiliation: Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands. Arthritis Centre Twente, Department of Psychology, Health and Technology, University of Twente, Arthritis Centre Twente, Department of Rheumatology and Clinical Immunology, Medical Spectrum Twente, Enschede and IQ Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Mart A F J
authors.initials: MA
authors.lastname: van de Laar
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management / Q000706:statistics & numerical data*; D010147:Pain Measurement; D017060:Patient Satisfaction; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents
keywords: cohort study; disease-modifying anti-rheumatic drugs; pain; rheumatoid arthritis