title: [Resveratrol enhances radiosensitivity of human hypopharyngeal carcinoma cell line in nude mice].
abstract: OBJECTIVE
  To study the radiosensitizing effect of resveratrol on human hypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice.
  
  
  METHODS
  Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining.
  
  
  RESULTS
  The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups.
  
  
  CONCLUSIONS
  Resveratrol can produce a radiosensitizing effect on human hypopharyngeal carcinoma in nude mice.
authors.affiliation: Department of Otorhinolaryngology-Head Neck Surgery, First Affiliated of Xi'an Jiao Tong University, Xi'an 710061, China. E-mail: quanfang2013@163.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Quan
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shao
authors.forename: Honghui
authors.initials: H
authors.lastname: Li
authors.forename: Ruimin
authors.initials: R
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D045744:Cell Line, Tumor / Q000528:radiation effects; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D000077185:Resveratrol; D000077195:Squamous Cell Carcinoma of Head and Neck; D013267:Stilbenes / Q000494:pharmacology*; D014183:Transplantation, Heterologous; D047368:Tumor Burden
chemical_list: D011838:Radiation-Sensitizing Agents; D013267:Stilbenes; D000077185:Resveratrol