title: European Initial Hands-On Experience with HEMOPATCH, a Novel Sealing Hemostatic Patch: Application in General, Gastrointestinal, Biliopancreatic, Cardiac, and Urologic Surgery.
abstract: Topical hemostatic agents that can seal tissues and assist in the coagulation cascade of patients undergoing surgery have been readily available for several decades. Using either synthetic or animal/plant-derived materials, these agents represent a powerful tool to reduce postoperative bleeding complications in cases where mechanical or energy-driven hemostasis is not possible or insufficient. Recently, a novel sealing hemostatic patch, HEMOPATCH (Baxter International, Deerfield, IL), was developed. The device is a thin and flexible patch consisting of a specifically-formulated porous collagen matrix, coated on one side with a thin protein-binding layer. This gives the patch a dual mechanism of action, in which the two components interact to achieve hemostasis by sealing off the bleeding surface and initiating the body's own clotting mechanisms. Here we present a series of case reports that outline the quick, effective hemostatic sealing of HEMOPATCH in a variety of clinical applications, including solid organ, gastrointestinal, biliopancreatic, endocrine, cardiovascular, and urologic surgeries. Essentially a feasibility study, these reports demonstrate how HEMOPATCH can be applied to seal almost any bleeding surface encountered during a range of procedures. Our results show that the device is eminently capable in both via laparotomy and laparoscopic approaches, and in patients with impaired coagulation or highly variable anatomies. In conclusion, our cases document the ease-of-use, application, and immediate hemostatic effect of the patch across a broad range of surgical settings and paves the way for future randomized clinical trials with more extensive follow-up.
authors.affiliation: Section for Surgical Research, Department of Surgery Medical University of Graz Graz, Austria.
authors.forename: Abe
authors.initials: A
authors.lastname: Fingerhut
authors.affiliation: Clinical Division of General Surgery, Department of Surgery Medical University of Graz Graz, Austria.
authors.forename: Selman
authors.initials: S
authors.lastname: Uranues
authors.affiliation: Department of HPB Surgery and Liver Transplantation San Camillo Hospital Rome, Italy.
authors.forename: Giuseppe Maria
authors.initials: GM
authors.lastname: Ettorre
authors.affiliation: Department of HPB Surgery and Liver Transplantation San Camillo Hospital Rome, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Felli
authors.affiliation: Department of HPB Surgery and Liver Transplantation San Camillo Hospital Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Colasanti
authors.affiliation: Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery University of Palermo, School of Medicine Palermo, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Scerrino
authors.affiliation: Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery University of Palermo, School of Medicine Palermo, Italy.
authors.forename: Giusepina Irene
authors.initials: GI
authors.lastname: Melfa
authors.affiliation: Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery University of Palermo, School of Medicine Palermo, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Raspanti
authors.affiliation: Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery University of Palermo, School of Medicine Palermo, Italy.
authors.forename: Gaspare
authors.initials: G
authors.lastname: Gulotta
authors.affiliation: Department of Visceral and Vascular Surgery Johanniter Hospital Rheinhausen Duisburg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Meyer
authors.affiliation: Department of Cardiac Surgery Asklepios Hospital St. Georg Hamburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Oberhoffer
authors.affiliation: Department of Cardiac Surgery Asklepios Hospital St. Georg Hamburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schmoeckel
authors.affiliation: Department of Cardiac Surgery European Hospital Rome, Italy.
authors.forename: Luca Paolo
authors.initials: LP
authors.lastname: Weltert
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Graziano
authors.initials: G
authors.lastname: Vignolini
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Salvi
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Masieri
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Vittori
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Siena
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Minervini
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Serni
authors.affiliation: Department of Urology Careggi Hospital, University of Florence Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Carini