title: Unusual Cause and Presentation of Collapsing Focal Segmental Glomerulosclerosis.
abstract: Collapsing focal segmental glomerulosclerosis (c-FSGS), a structural variant of focal segmental glomeruloslecrosis (FSGS), is considered to be the most aggressive FSGS form. Most patients present with severe nephrotic syndrome and often have rapidly progressing renal failure and progression to end-stage kidney disease. We are reporting a 28-year-old previously healthy woman, who was started on griseofulvin for onchomycosis; she subsequently developed acute renal failure with significant proteinuria. Exposure to the drug caused dramatic decline in the renal function. Renal biopsy was compatible with c-FSGS. To the best of our knowledge, this is the first case of biopsy-proven griseofulvin-associated c-FSGS. Our patient showed rapid improvement in renal function after discontinuation of griseofulvin. Universally, c-FSGS carries poor prognosis, but this case is unique because patient showed rapid improvement in renal function with a short duration after cessation of griseofulvin.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Wayne State University-Detroit Medical Center, Detroit, MI.
authors.forename: Zeenat Yousuf
authors.initials: ZY
authors.lastname: Bhat
authors.forename: Neetu
authors.initials: N
authors.lastname: Sharma
authors.forename: Unnikrishnana
authors.initials: U
authors.lastname: Pillai
authors.forename: Atul
authors.initials: A
authors.lastname: Singh
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006118:Griseofulvin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D014009:Onychomycosis / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D006118:Griseofulvin