title: Freeze dried cross linking free biodegradable composites with microstructures for tissue engineering and drug delivery application.
abstract: Biodegradable laminated polymer composites of agarose (A), gelatin (G) and hydroxyapatite (HAp) having 3D network of interconnected pores (1-500 μm) were fabricated without using cross linking agents. The incorporation of HAp to A, G and AG had considerable influence on the swelling behaviour, drug release and haemolytic activity. A-HAp scaffolds demonstrated interconnected porosity with extended drug release. G-HAp scaffolds possessed enhanced mechanical property. AG-HAp scaffolds exhibited extended drug delivery, haemocompatibility and efficacy against Gram positive bacteria compared with G-HAp. Hence, AG-HAp composites could be used us a scaffold for tissue engineering and drug delivery system. This method provides non toxic, versatile and cost effective biodegradable scaffolds which could be used for various biomedical applications.
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India.
authors.forename: M I Ahymah
authors.initials: MI
authors.lastname: Joshy
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India.
authors.forename: K
authors.initials: K
authors.lastname: Elayaraja
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India.
authors.forename: N
authors.initials: N
authors.lastname: Sakthivel
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India.
authors.forename: V Sarath
authors.initials: VS
authors.lastname: Chandra
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India.
authors.forename: G M
authors.initials: GM
authors.lastname: Shanthini
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600 025, India. Electronic address: kalkurasn@annauniv.edu.
authors.forename: S Narayana
authors.initials: SN
authors.lastname: Kalkura
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D055119:Elastic Modulus / Q000187:drug effects; D005612:Freeze Drying; D005780:Gelatin / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D016062:Porosity; D012685:Sepharose / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D000658:Amoxicillin; D005780:Gelatin; D012685:Sepharose; D017886:Durapatite