title: Analysis of the stent expansion in a stenosed artery using finite element method: application to stent versus stent study.
abstract: In this article, finite element method is used to investigate the mechanical behavior of a stent and to determine the biomechanical interaction between the stent and the artery in a stenting procedure. The main objective of this study is to reach to a model close to a real condition of coronary stent placement. Unlike most of the models proposed in the literature, all the steps of the deployment of a stent in the stenotic vessel (i.e. pressure increasing, constant load pressure and pressure decreasing) are simulated in this article to show the behavior of the stent in different stages of implantation. The results indicate that the first step of deployment, that is, pressure increasing, plays a main role in the success of stent implantation. So that, in order to compare the behavior of different types of stents, it is sufficient to compare their behavior at the end of pressure increasing step. In order to show the application of the findings in stent versus stent studies, three commercially available stents (the Palmaz-Schatz, Multi-Link and NIR stents) are modeled and their behavior is compared at the end of pressure increasing step. The effect of stent design on the restenosis rate is investigated. According to the findings, the possibility of restenosis is lower for Multi-Link and NIR stents in comparison with Palmaz-Schatz stent which is in good agreement with clinical results. Therefore, the testing methodology outlined here is proposed as a simple and economical alternative for "stent versus stent" complicated clinical trials.
authors.affiliation: Department of Mechanical Engineering, Sari Branch, Islamic Azad University, Sari, Iran misagh.imani@gmail.com.
authors.forename: S Misagh
authors.initials: SM
authors.lastname: Imani
authors.affiliation: Department of Mechanical Engineering, Babol University of Technology, Babol, Iran.
authors.forename: A M
authors.initials: AM
authors.lastname: Goudarzi
authors.affiliation: Young Researchers and Elite Club, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors.forename: S E
authors.initials: SE
authors.lastname: Ghasemi
authors.affiliation: Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Kalani
authors.affiliation: Department of Mechanical Engineering, Sari Branch, Islamic Azad University, Sari, Iran.
authors.forename: J
authors.initials: J
authors.lastname: Mahdinejad
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D019245:Compressive Strength; D003198:Computer Simulation; D017076:Computer-Aided Design; D023921:Coronary Stenosis / Q000503:physiopathology* / Q000601:surgery*; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D033081:Shear Strength; D015607:Stents; D013314:Stress, Mechanical; D013718:Tensile Strength; D014783:Viscosity
keywords: Stenosed artery; balloon; finite element method; plaque; stent versus stent study