title: Genetics of psoriasis.
abstract: Psoriasis is a common and debilitating immune-mediated skin disease with a complex genetic basis. Genetic studies have provided critical insights into the pathogenesis of disease. This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted.
authors.affiliation: Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, King's College London, 9th Floor, Tower Wing, London SE1 9RT, UK.
authors.forename: Satveer K
authors.initials: SK
authors.lastname: Mahil
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, 9th Floor, Tower Wing, London, SE1 9RT, UK.
authors.forename: Francesca
authors.initials: F
authors.lastname: Capon
authors.affiliation: Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, King's College London, 9th Floor, Tower Wing, London SE1 9RT, UK. Electronic address: jonathan.barker@kcl.ac.uk.
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Barker
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D012879:Skin Physiological Phenomena / Q000235:genetics
keywords: Genetics; Genome-wide association studies; Psoriasis; Stratification