title: Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease.
abstract: To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.
authors.affiliation: 1 Neurology, University "Campus Biomedico" , Rome, Italy .
authors.forename: Stefania
authors.initials: S
authors.lastname: Mariani
authors.forename: Mariacarla
authors.initials: M
authors.lastname: Ventriglia
authors.forename: Illaria
authors.initials: I
authors.lastname: Simonelli
authors.forename: Serena
authors.initials: S
authors.lastname: Bucossi
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Siotto
authors.forename: Rosanna Squitti
authors.initials: RS
authors.lastname: R
mesh_terms: D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008715:Methionine / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human; D008715:Methionine; D014633:Valine