title: Extending the donor pool: rehabilitation of poor organs.
abstract: The number of patients listed for lung transplantation exceeds the number of available transplantable organs because of a shortage of organ donors and a low utilization rate of donated lungs. A novel strategy of donor lung management, called ex vivo lung perfusion (EVLP) can keep the organ in a physiologic protective condition, and promises to increase lung utilization by reevaluating, treating, and repairing donor lungs before transplantation. Preclinical studies have shown great potential for EVLP as a platform for the delivery of novel therapies to repair injured organs ex vivo and improve the success of lung transplantation.
authors.affiliation: Division of Thoracic Surgery, University of Toronto, 200 Elizabeth Street, 9N-969, Toronto, Ontario M5G 2C4, Canada.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
authors.affiliation: Toronto Lung Transplant Program, Division of Thoracic Surgery, University of Toronto, 200 Elizabeth Street, 9N-946, Toronto, Ontario M5G 2C4, Canada. Electronic address: shaf.keshavjee@uhn.ca.
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D016040:Lung Transplantation; D009926:Organ Preservation / Q000379:methods; D010477:Perfusion / Q000379:methods; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Ex vivo lung perfusion; Lung transplantation; Organ preservation