title: Morphological structure and characteristics of hydroxyapatite/β-cyclodextrin composite nanoparticles synthesized at different conditions.
abstract: Hydroxyapatite (HA) nanoparticles were prepared simply in the presence of β-cyclodextrin (β-CD). Mixing sequence of ion precursors during the synthesis of HA greatly affected the morphological structure of nanoparticles. Ca-P showed only the sphere-like structure, however P-Ca exhibited the mixture of spherical and rod-like nanoparticles. The size of nanoparticles slightly decreased with increasing the content of β-CD. The HAs synthesized in the presence of β-CD agglomerated, leading to the formation of aggregates with a size of hundreds nanometer and narrow size distribution. FT-IR, XRD and XRF analyses confirmed that the HA nanoparticles could be synthesized with using β-CD, in which the Ca/P molar ratio was ranged from 1.72 to 1.70. The crystalline phase of these HA nanoparticles was similar to that of the stoichiometric HA. In addition, the content of β-CD contained in the products could influence the initial deposition rate of bone-like apatite on the surface of HA nanoparticles in simulated body fluid (SBF).
authors.affiliation: Department of Biomedical Engineering, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea.
authors.forename: Kyoung Dan
authors.initials: KD
authors.lastname: Son
authors.affiliation: Department of Biomedical Engineering, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea. Electronic address: yjkim@cu.ac.kr.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D001826:Body Fluids / Q000737:chemistry; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D017886:Durapatite; C031215:betadex