title: DNA photocleavage in anaerobic conditions by a Ru(ii) complex: a new mechanism.
abstract: [Ru(bpy)2(py-SO3)](+) (bpy = 2,2'-bipyridine and py-SO3 = pyridine-2-sulfonate) was found to undergo py-SO3 dissociation upon visible light irradiation (≥470 nm) via Ru-O homolysis, producing reactive free radical species, and is thus able to not only photobind but also photocleave DNA in hypoxic conditions.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. xswang@mail.ipc.ac.cn zhouqianxiong@mail.ipc.ac.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zheng
authors.forename: Qianxiong
authors.initials: Q
authors.lastname: Zhou
authors.forename: Wanhua
authors.initials: W
authors.lastname: Lei
authors.forename: Yuanjun
authors.initials: Y
authors.lastname: Hou
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Chen
authors.forename: Baowen
authors.initials: B
authors.lastname: Zhang
authors.forename: Xuesong
authors.initials: X
authors.lastname: Wang
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000693:Anaerobiosis; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects*; D005609:Free Radicals / Q000737:chemistry; D008027:Light; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010782:Photolysis / Q000187:drug effects*; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005609:Free Radicals; D009942:Organometallic Compounds; D013451:Sulfonic Acids; C103599:bis(bipyridyl)ruthenium(II); D015082:2,2'-Dipyridyl; D004247:DNA