title: Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels.
abstract: Selective inhibitors of voltage-activated K(+) channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.
authors.affiliation: School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. kieran.nolan@dcu.ie.
authors.forename: D
authors.initials: D
authors.lastname: Daly
authors.forename: A
authors.initials: A
authors.lastname: Al-Sabi
authors.forename: G K
authors.initials: GK
authors.lastname: Kinsella
authors.forename: K
authors.initials: K
authors.lastname: Nolan
authors.forename: J O
authors.initials: JO
authors.lastname: Dolly
mesh_terms: D064751:Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D026902:Potassium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D055366:Synaptic Potentials / Q000187:drug effects*
chemical_list: D064751:Ammonium Compounds; D011166:Porphyrins; D026902:Potassium Channel Blockers; D015221:Potassium Channels