title: Synthesis and antiepileptic activity of schiff's bases of dialkylamino alkoxy isatin derivatives.
abstract: In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 3-thiosemicarbazone 2-ones and 5-[2(3)-dialkylamino alkoxy] Indole 3-hydrazone 2-one were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, and MASS Spectral studies. All the compounds were examined for antiepileptic activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) induced convulsion method. These compounds were also evaluated for their neurotoxicity study by rotarod method. Some of these compounds showed good antiepileptic activity when compared with standard drug Phenytoin and all the compounds showed less neurotoxicity when compared with standard drug Diazepam.
authors.affiliation: Medicinal Chemistry Laboratory, U.C.P.Sc., Kakatiya University, Warangal, 506009, Telangana, India, kswathi84@yahoo.co.in.
authors.forename: Konda
authors.initials: K
authors.lastname: Swathi
authors.forename: Manda
authors.initials: M
authors.lastname: Sarangapani
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004597:Electroshock / Q000009:adverse effects; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole; D012545:Schiff Bases / Q000737:chemistry; D012640:Seizures / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013055:Spectrophotometry, Infrared; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000438:Alcohols; D000927:Anticonvulsants; D006835:Hydrazones; D007211:Indoles; D012545:Schiff Bases; D013882:Thiosemicarbazones; C059688:alkoxyl radical; D007510:Isatin; D010433:Pentylenetetrazole