title: The effect of exercise on lipid profiles and inflammatory markers in lean male adolescents: a prospective interventional study.
abstract: BACKGROUND
  Physical activity improves body composition and inflammatory markers in obese individuals, but little is known about the nonobese population.
  
  
  OBJECTIVE
  The aim of this study was to investigate associations between exercise and inflammatory cytokines in lean male adolescents in Taiwan.
  
  
  METHODS
  This interventional study enrolled a total of 79 normal body weight male adolescents [mean age, 16.8 (1.0) years] from the Army Academy of Taiwan. Body composition and inflammatory markers were measured at baseline and upon completion of a 12-week exercise intervention program.
  
  
  RESULTS
  Subjects' postintervention anthropometric measures, including waist circumference [74.6 (5.2)→72.6 (5.2) cm], hip circumference [92.3 (4.1)→89.9 (5.0) cm], body fat mass [10.2 (3.2)→8.2 (3.2) kg], and body fat percentage [15.8% (4.2)→12.6 (4.5)%] declined significantly compared to preintervention (all P<0.001), as did systolic blood pressure (P=0.002) and mean blood pressure (P = 0.020). Postintervention body height and free fat mass increased significantly (both P<0.001). Subjects' postintervention lipids including total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides increased significantly (all P<0.001). Inflammatory markers including adiponectin [14.32 (6.68)→31.31 (30.53) μg/mL, P<0.001], interleukin 6 [2.15 (4.81)→2.86 (6.37) pg/mL, P=0.005], and C-reactive protein [1.00 (2.57)→2.30 (4.17) μg/mL, P<0.001] increased significantly postintervention, but not leptin.
  
  
  CONCLUSIONS
  Exercise training significantly improves body composition and anti-inflammatory adiponectin levels in lean male adolescents.
authors.affiliation: From the *Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital; †Department of Medicine, National Yang-Ming University; ‡Department of Neurology, Tri-Service General Hospital; §School of Public Health, National Defense Medical Center; ∥Department of Medical Research, Taipei Veterans General Hospital; and ¶Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chun-Jui
authors.initials: CJ
authors.lastname: Huang
authors.forename: Chin-Fai
authors.initials: CF
authors.lastname: Kwok
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Chou
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chou
authors.forename: Low-Tone
authors.initials: LT
authors.lastname: Ho
authors.forename: Kuang-Chung
authors.initials: KC
authors.lastname: Shih
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D016207:Cytokines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D013851:Thinness / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin; D008055:Lipids