title: Relationship and factors responsible for regulating fasting and post-challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus.
abstract: OBJECTIVE
  Elevation of 2-h plasma glucose (2-h PG) levels keeps step with fasting plasma glucose (FPG) levels elevation, but some individuals show dominant elevation of 2-h PG and others FPG. We analyzed dependent and independent relationships between 2-h PG and FPG, and investigated the factors regulating 2-h PG and FPG.
  
  
  METHODS
  In 1,657 Japanese participants who underwent a 75-g oral glucose tolerance test at the initial examination for a medical check-up, we carried out simple linear regression analysis between 2-h PG and FPG levels on the three patterns of independent variables. We divided the participants into two subgroups: the 2-h PG-side group and the FPG-side from the regression line, and examined the relationships between 2-h PG-FPG and factors responsible for elevation of plasma glucose levels.
  
  
  RESULTS
  There was a significant positive correlation between 2-h PG and FPG levels. The regression line of both 2-h PG and FPG as independent variables was in accordance with the regression line of 2-h PG as an independent variable and FPG as a dependent variable. In 2-h PG-side group, age was the independent factor affecting 2-h PG in addition to insulinogenic index and insulin sensitivity index (ISI composite). In the FPG-side group, triglyceride was the independent factor affecting FPG in addition to insulinogenic index and ISI composite.
  
  
  CONCLUSIONS
  Two-hour PG was an independent predictor of FPG. In addition to the importance of decreased insulin secretion and insulin sensitivity, age was the strong factor to elevate 2-h PG levels in the 2-h PG-side group and triglyceride was the strong factor to elevate FPG levels in the FPG-side group in the early stage of development of type 2 diabetes.
authors.affiliation: Division of Clinical Nutrition and Internal Medicine, Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University Okayama, Japan.
authors.forename: Sae
authors.initials: S
authors.lastname: Aoyama-Sasabe
authors.affiliation: Department of Systems Engineering, Faculty of Computer Science and Systems Engineering, Okayama Prefectural University Okayama, Japan.
authors.forename: Xin
authors.initials: X
authors.lastname: Xin
authors.affiliation: Division of Diabetes and Endocrinology, Kyoto Preventive Medical Center Kyoto, Japan.
authors.forename: Ataru
authors.initials: A
authors.lastname: Taniguchi
authors.affiliation: Kyoto Institute of Health Science Kyoto, Japan.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Nakai
authors.affiliation: Center for Preventive Medicine, St. Luke's International Hospital Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Mitsui
authors.affiliation: Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University Okayama, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tsuji
authors.affiliation: Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital Osaka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yabe
authors.affiliation: Department of Diabetes and Endocrinology, Saiseikai Noe Hospital Osaka, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurose
authors.affiliation: Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University Kyoto, Japan.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Inagaki
authors.affiliation: Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital Osaka, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
authors.affiliation: Division of Clinical Nutrition and Internal Medicine, Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University Okayama, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
keywords: Fasting plasma glucose; Post-challenge plasma glucose; Type 2 diabetes