title: Soluble receptor for advanced glycation end products in critically ill patients and its associations with other clinical markers and 28-day mortality.
abstract: OBJECTIVE
  To investigate the possible associations between serum levels of soluble receptor for advanced glycation end products (sRAGE) and specific clinical markers and prognosis in critically ill patients diagnosed with stress hyperglycemia.
  
  
  METHODS
  A total of 70 critically ill patients and 25 normal controls were recruited for this study. Serum levels of sRAGE and advanced glycation end products (AGEs) were determined using enzyme-linked immunosorbent assay. Additional data on other clinical markers were obtained from patient records in the intensive care unit. Comparisons of sRAGE and AGEs levels between groups were assessed by t-test. The relationships between sRAGE and other clinical markers were assessed by Pearson's correlation analyses and multiple linear regression analyses. Risk factors for prognosis, such as 28-day mortality were analyzed using logistic regression analysis.
  
  
  RESULTS
  Serum sRAGE and AGEs levels were significantly higher in critically ill patients, compared to normal controls (P<0.05). The increase in serum sRAGE levels was significantly correlated with AGEs levels, interleukin-6 levels, and the sequential organ failure assessment score (P<0.01). Using multiple linear regression analysis, the association between AGEs and sRAGE remained significant after adjustment of other clinical factors. However, there were no significant correlations between sRAGE levels and patient outcome in these critically ill patients.
  
  
  CONCLUSIONS
  Serum sRAGE levels were significantly elevated in critically ill patients and positively correlated with higher AGEs levels, but sRAGE levels were not associated with increased mortality, suggesting sRAGE levels are not a predictor of prognosis in critically ill patients.
authors.affiliation: Department of Intensive Care Unit, Zhuhai People's Hospital, Zhuhai, Guangdong, People's Republic of China.
authors.forename: Yanzi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Intensive Care Unit, Zhuhai People's Hospital, Zhuhai, Guangdong, People's Republic of China.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Intensive Care Unit, Zhuhai People's Hospital, Zhuhai, Guangdong, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Department of Intensive Care Unit, Zhuhai People's Hospital, Zhuhai, Guangdong, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Dehong
authors.initials: D
authors.lastname: Cai
authors.affiliation: Department of Intensive Care Unit, Zhuhai People's Hospital, Zhuhai, Guangdong, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhao
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D016638:Critical Illness / Q000401:mortality*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D015850:Interleukin-6 / Q000097:blood; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D011379:Prognosis; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced; D015850:Interleukin-6; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D003404:Creatinine
keywords: advanced glycation end products; critically ill patients; predictor; relationship; soluble receptor for advanced glycation end products