title: Fluorescent organic nanoparticles of dihydropyrimidone derivatives for selective recognition of iodide using a displacement assay: application of the sensors in water and biological fluids.
abstract: Fluorescent organic nanoparticles (FON's) derived from dihydropyrimidone derivatives (1-4) were developed and evaluated for their sensor properties. Nano-aggregates of compound 3 and 4 resulted in sensors. Nano-aggregates of compound 3 showed enhancement in the monomer peaks of the pyrene moiety after the addition of mercury. Nano-aggregates of compound 4 resulted in quenching of intensity upon addition of Hg(2+). On the other hand, no sensor activity was recorded for nano-aggregates of compounds 1 and 2. Further, the complex of nano-aggregates of 3 and mercury (3·Hg(2+)) recognised iodide ions by showing quenching in monomer and excimer emission with a detection limit of 0.2 nM in aqueous medium; however the resultant metal complex 4·Hg(2+) does not show any anion sensing activity. Receptor 3·Hg(2+) has a highly sensitive and selective response toward I(-) ions. Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum. To the best of our knowledge, the system represents the first example of iodide recognition using FONs.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Panjab, India140001. nsingh@iitrpr.ac.in.
authors.forename: Amanpreet
authors.initials: A
authors.lastname: Kaur
authors.forename: Tilak
authors.initials: T
authors.lastname: Raj
authors.forename: Simanpreet
authors.initials: S
authors.lastname: Kaur
authors.forename: Narinder
authors.initials: N
authors.lastname: Singh
authors.forename: Navneet
authors.initials: N
authors.lastname: Kaur
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D004095:Dihydropyridines / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007454:Iodides / Q000032:analysis* / Q000097:blood / Q000652:urine; D008628:Mercury / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004095:Dihydropyridines; D005456:Fluorescent Dyes; D007454:Iodides; D014867:Water; D008628:Mercury