title: Aerogenous metastases: a potential game changer in the diagnosis and management of primary lung adenocarcinoma.
abstract: OBJECTIVE
  The purposes of this article are to summarize the relevant literature on aerogenous metastasis, explain the putative pathogenetic mechanism of aerogenous spread, present the characteristic imaging and pathologic features, and review the importance of aerogenous spread to staging and clinical management.
  
  
  CONCLUSIONS
  Cumulative evidence suggests that aerogenous spread may exist and is underrecognized. Imaging features are helpful in differentiating possible aerogenous spread of tumor from hematogenous and lymphatic metastases and from synchronous primary tumors. The putative occurrence of intrapulmonary aerogenous metastasis of lung cancer has staging, management, and prognostic implications.
authors.affiliation: 1 Southcoast Radiology, Mackay, Queensland, Australia.
authors.forename: Anand
authors.initials: A
authors.lastname: Gaikwad
authors.forename: Carolina A
authors.initials: CA
authors.lastname: Souza
authors.forename: Joao R
authors.initials: JR
authors.lastname: Inacio
authors.forename: Ashish
authors.initials: A
authors.lastname: Gupta
authors.forename: Harmanjatinder S
authors.initials: HS
authors.lastname: Sekhon
authors.forename: Jean M
authors.initials: JM
authors.lastname: Seely
authors.forename: Carole
authors.initials: C
authors.lastname: Dennie
authors.forename: Marcio M
authors.initials: MM
authors.lastname: Gomes
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: aerogenous metastases; lung adeno-carcinoma; metastases