title: The evaluation of the outcome in myelodysplastic patients by using non-cytogenetic prognostic scores.
abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders; they are characterized by ineffective hematopoiesis and a predilection to the development of acute myeloid leukemia (AML). For a rapid evaluation of the outcome in myelodysplastic patients non-cytogenetic prognostic scores can be used.
  
  
  OBJECTIVE
  This study proposed to demonstrate that age and gender are important factors in the outcome of the patients diagnosed with myelodysplastic syndrome.
  
  
  METHODS
  This study was conducted in the Department of Hematology of the Emergency University Hospital Bucharest during October 2008 and October 2012.
  
  
  RESULTS
  Male sex and age higher than 60 years are associated with high risk in the studied cases by using the Spanish prognostic score. According to Goasguen score: male sex and age, patients older than 60 years, present characteristics associated with an intermediate risk. Based on the Dusseldorf score, age over 60 years and female gender were associated with pronounced risk in the examined group. By examining the Bournemouth score in our group, we found that age > 60 years correlated with a higher frequency of risk, but no significant differences regarding the sex of patients were observed.
  
  
  CONCLUSIONS
  We concluded that age > 60 years and male gender are important predisposing factors in the survival.
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: O
authors.initials: O
authors.lastname: Căzăceanu
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: Am
authors.initials: A
authors.lastname: Vlădăreanu
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: H
authors.initials: H
authors.lastname: Bumbea
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Begu
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Onisai
authors.affiliation: University Emergency Hospital, Department of Hematology, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Enache
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology*; D011379:Prognosis; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D012737:Sex Factors
keywords: acute myeloid leukemia; myelodysplastic syndrome; prognostic score