title: A comparative evaluation of platelet-rich plasma in combination with demineralized freeze-dried bone allograft and DFDBA alone in the treatment of periodontal intrabony defects: A clinicoradiographic study.
abstract: The aim of the present clinical trial was to compare PRP combined with a DFDBA to DFDBA mixed with a normal saline solution in the treatment of human intrabony defects.
  
  
  
  Twenty interproximal intrabony osseous defects in twenty non-smoking, healthy subjects diagnosed with chronic periodontitis were treated in this study. Ten subjects each were randomly assigned to the test group (PRP + DFDBA) or the control group (DFDBA + saline). Clinical and radiographic measurements were made at baseline, three month and at six-month evaluation.
  
  
  
  The results at three and six months, when compared to the baseline, indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth, clinical attachment level and gingival recession; P < 0.01) and radiographic parameters (hard-tissue fill and bone-depth reduction; P < 0.01). However, the test group exhibited statistically significantly greater changes compared to the control group in plaque index at three months (P = 0.00), probing depth reduction at 6 months (P = 0.02) and the radiographic defect fill at 6 months (P = 0.01).
  
  
  
  Treatment with a combination of PRP and DFDBA led to a statistically significantly greater improvement in plaque index at 3 months, probing depth at 6 months and radiographic defect fill at 6 months in intrabony periodontal defects as compared to DFDBA with normal saline.
authors.affiliation: Department of Periodontology, I.T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Bhavna Jha
authors.initials: BJ
authors.lastname: Kukreja
authors.affiliation: Department of Periodontology, I.T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Dodwad
authors.affiliation: Department of Oral and Maxillofacial Surgery, I.T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kukreja
authors.affiliation: Department of Private Practice in Periodontology, I.T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Sakshi
authors.initials: S
authors.lastname: Ahuja
authors.affiliation: Department of Prosthodontics, I.T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Praful
authors.initials: P
authors.lastname: Mehra
keywords: Allograft; bone; defect; regeneration