title: Archaeal DNA replication.
abstract: DNA replication is essential for all life forms. Although the process is fundamentally conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic studies have demonstrated that the process and the proteins involved in archaeal DNA replication are more similar to those in eukaryal DNA replication than in bacterial DNA replication, but have some archaeal-specific features. The archaeal replication system, however, is not monolithic, and there are some differences in the replication process between different species. In this review, the current knowledge of the mechanisms governing DNA replication in Archaea is summarized. The general features of the replication process as well as some of the differences are discussed.
authors.affiliation: Program in Biotechnology, Montgomery College, Germantown, Maryland 20876; email: lori.kelman@montgomerycollege.edu.
authors.forename: Lori M
authors.initials: LM
authors.lastname: Kelman
authors.forename: Zvi
authors.initials: Z
authors.lastname: Kelman
mesh_terms: D001105:Archaea / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D019641:DNA, Archaeal / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics
chemical_list: D019641:DNA, Archaeal; D004268:DNA-Binding Proteins; D004265:DNA Helicases
keywords: Archaea; initiation of DNA replication; protein structure; protein-DNA interactions; protein-protein interactions; regulation of DNA replication