title: Hyperpigmentation in palms associated with lung adenocarcinoma resolving after chemotherapy.
abstract: OBJECTIVE
  Hyperpigmentation is a kind of paraneoplastic syndrome associated with lung cancer. Diffuse hyperpigmentation was reported and generally resulted from overproduction of melanocyte-stimulating hormone or adrenocorticotropic hormone. However, localized hyperpigmentation is rare for lung cancer.
  
  
  METHODS
  Here, we report a 56-year-old lung adenocarcinoma patient who developed hyperpigmentation in two palms about 3 months preceding the diagnosis and resolved gradually with the shrink of the primary tumours in lung after chemotherapy.
  
  
  RESULTS
  Localized hyperpigmentation suggests that another mechanism might be involved.
  
  
  CONCLUSIONS
  The case reminds us that any skin disorders without obvious causes in heavy smokers should be alerted as a sign of lung cancer and sometimes could be used as a marker of response to the treatment.
authors.affiliation: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Fengying
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Su
authors.affiliation: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jianfang
authors.initials: J
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D004358:Drug Therapy; D006225:Hand / Q000473:pathology*; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
keywords: hyperpigmentation; lung cancer; paraneoplastic syndrome