title: Lactobacillus rhamnosus GG Reverses Insulin Resistance but Does Not Block Its Onset in Diet-Induced Obese Mice.
abstract: Recently, Lactobacillus rhamnosus GG (LGG) was shown to exert insulin-sensitizing and adiposity-reducing effects in high-fat (HF) diet-fed mice. In the present study, we observed that the effects were correlated with the extent of dysbiosis induced by HF diet feeding before LGG administration. LGG-treated mice were protected from HF diet-induced adiposity and/ or insulin resistance when LGG was treated after, not along with, HF diet feeding. Results indicate that, under HF dietary condition, supplemented LGG reverses insulin resistance, but does not block its onset.
authors.affiliation: School of Life Science, Handong Global University, Pohang 791-708, Republic of Korea.
authors.forename: Kun-Young
authors.initials: KY
authors.lastname: Park
authors.affiliation: School of Life Science, Handong Global University, Pohang 791-708, Republic of Korea.
authors.forename: Bobae
authors.initials: B
authors.lastname: Kim
authors.affiliation: School of Life Science, Handong Global University, Pohang 791-708, Republic of Korea.
authors.forename: Chang-Kee
authors.initials: CK
authors.lastname: Hyun
mesh_terms: D052242:Adiponectin; D050154:Adiposity; D000818:Animals; D059305:Diet, High-Fat; D064806:Dysbiosis; D007333:Insulin Resistance / Q000502:physiology*; D052201:Lacticaseibacillus rhamnosus; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D019936:Probiotics / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D052242:Adiponectin