title: Ameloblastic carcinoma with features of ghost cell odontogenic carcinoma in a patient with suspected Gardner syndrome.
abstract: Ameloblastic carcinoma and ghost cell odontogenic carcinoma are rare malignancies arising in odontogenic epithelium within the jaws. Gardner syndrome is a multifaceted autosomal dominant condition, which results in multiple dentofacial anomalies along with premalignant colon polyp formation and tumor formation in the skin and other organs. We report a case of ameloblastic carcinoma with features of ghost cell odontogenic carcinoma and extensive clear cell change and melanin pigmentation in a patient with clinical features of Gardner syndrome. To the best of our knowledge, odontogenic carcinoma arising in a patient with features of Gardner syndrome has not been reported previously. The clinical, radiographic, and histologic features of the case are discussed along with a review of the relevant literature.
authors.affiliation: Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: sarah.fitzpatrick@case.edu.
authors.forename: S G
authors.initials: SG
authors.lastname: Fitzpatrick
authors.affiliation: Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Hirsch
authors.affiliation: Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Listinsky
authors.affiliation: Former Intern, Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA, current Oral and Maxillofacial Surgery Resident, Department of Oral and Maxillofacial Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, USA.
authors.forename: D J-H
authors.initials: DJ
authors.lastname: Lyu
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Baur
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D003937:Diagnosis, Differential; D005736:Gardner Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009808:Odontogenic Tumors / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed