title: Expanding the donor pool: donation after cardiac death.
abstract: Lung transplantation (LTx) is the definitive treatment of patients with end-stage lung disease. Availability of donor lungs remains the primary limitation and leads to substantial wait-list mortality. Efforts to expand the donor pool have included a resurgence of interest in the use of donation after cardiac death (DCD) lungs. Unique in its physiology, lung viability seems more tolerant to the variable durations of ischemia that occur in DCD donors. Initial experience with DCD LTx is promising and, in combination with ex vivo lung perfusion systems, seems a valuable opportunity to expand the lung donor pool.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Haytham
authors.initials: H
authors.lastname: Elgharably
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Baylor University Medical Center, 3409 Worth Street, Suite 640, Dallas, TX 75246, USA.
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Shafii
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Baylor University Medical Center, 3409 Worth Street, Suite 640, Dallas, TX 75246, USA. Electronic address: David.Mason@Baylorhealth.edu.
authors.forename: David P
authors.initials: DP
authors.lastname: Mason
mesh_terms: D003643:Death; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000379:methods*; D016896:Treatment Outcome; D014850:Waiting Lists
keywords: Donation after cardiac death; Ex vivo lung perfusion; Lung transplantation; Outcomes