title: Effects of Thyroid Stimulating Hormone (TSH) level on clinical pregnancy rate via In Vitro Fertilization (IVF) procedure.
abstract: BACKGROUND
  Subclinical hypothyroidism may adversely affect In Vitro Fertilization (IVF) outcomes. However the cutoff of thyroid-stimulating hormone (TSH) for diagnosis and treatment is controversal. The aim of this study was to find the association of clinical pregnancy rate with regard to TSH levels in women undergoing IVF.
  
  
  METHODS
  A historical cohort study of 816 infertile patients who underwent IVF in 2011 and 2012 was conducted. The study subjects were categorized in two groups according to their baseline TSH level; one with 0.5 ≤TSH< 2.5 mIU/L and other with 2.5 ≤TSH< 4.5 mIU/L. All patients were followed up for 6 weeks after embroyonic transfer. The outcomes of the study were consisted of rates for Human Chorionic Gonadotropin (HCG) and evaluation of their clinical pregnancies.
  
  
  RESULTS
  About 60% of the study subjects had serum TSH level < 2.5 mIU/L and 40% ≥ 2.5 mIU/L. There were no statistically significant differences in age, years of infertility, BMI, baseline FSH and estradiol level of patients and the type of induction protocols between the study groups. The HCG rise was occurred in 30.4% of the subjects with TSH level < 2.5 mIU/L versus 26.3% of the subjects with TSH ≥ 2.5 mIU/L (p value= 0.2). The clinical pregnancy rates in the group of patients with TSH < 2.5 mIU/L and those with ≥ 2.5 mIU/L were 27.1% and 23.9% respectively (p value= 0.3).
  
  
  CONCLUSIONS
  Our results were similar to various studies in which reported lack of association between TSH level in the range of 0.5- 4.5 mIU/L and IVF outcomes. It seems that lowering the upper limit of normal TSH should be still considered as a scientific debate.
authors.affiliation: 1. MD, Professor of Gynecology and Obstetrics, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. ivfshariati69@gmail.com.
authors.forename: Marziyeh
authors.initials: M
authors.lastname: Aghahosseini
authors.affiliation: 2. MD, Gynecology and Obstetrics specialist, Former resident of Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. asgharifard@razi.tums.ac.ir.
authors.forename: Homa
authors.initials: H
authors.lastname: Asgharifard
authors.affiliation: 3. MD, Professor of Gynecology and Obstetrics, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. ivfshariati69@gmail.com.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Aleyasin
authors.affiliation: 4. MD, MPH, PhD candidate of Epidemiology School of Public Health, Department of Epidemiology, Iran University of Medical Sciences, Tehran, Iran. tehranib@gmail.com.
authors.forename: Arash
authors.initials: A
authors.lastname: Tehrani Banihashemi
keywords: In Vitro Fertilization; Subclinical hypothyroidism; Thyroid stimulating hormone; clinical pregnancy