title: [Leptin as a neuroprotector and functional stability factor in the central neural system].
abstract: Adipokines secreted by adipose tissue are recognized to be crucial for the regulation and maintenance of energy homeostasis. Leptin is the best characterized adipokine involved in energy metabolism and inflammatory status, being associated with the development of a number of diseases, including atherosclerosis, diabetes, certain cancers and immune-mediated processes. Recently leptin was found to exert neurotrophic effects and neuroprotective activity slowing down neuronal damage after acute brain injuries as well as during long-term neurodegenerative processes. Moreover there are the evidences that leptin influences receptor signalling as well as the synthesis and releasing of several neurotransmitters. The aim of this review is to discuss the role of leptin in the neuroprotection and the regulation of diverse neuronal functions in the health and disease.
authors.forename: N B
authors.initials: NB
authors.lastname: Teryaeva
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D020738:Leptin / Q000494:pharmacology* / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D020738:Leptin; D018696:Neuroprotective Agents