title: Peripheral endothelial dysfunction as a marker of cardiovascular risk in physically healthy patients with schizophrenia and related psychoses: a matched case control study.
abstract: OBJECTIVE
  Our aim was to assess endothelial function in physically healthy patients with schizophrenia and related psychoses and to compare the results with healthy controls. Endothelial dysfunction was shown to predict future cardiovascular events in general population so we assumed to find a higher prevalence of endothelial dysfunction in patients with psychosis, as their cardiovascular morbidity is markedly higher than in general population, and to confirm the referred correlation with the traditional cardiovascular (CV) risk factors.
  
  
  METHODS
  We assessed the traditional CV risk factors and endothelial function using non-invasive peripheral arterial tonometry (EndoPAT2000) in 50 stabilized and medicated schizophrenic patients (aged between 18 and 50 years) without any history of cardiovascular diseases and compared the results with 50 age-matched healthy controls.
  
  
  METHODS
  Psychiatric Clinic, University Hospital, Hradec Kralove and 2nd Department of Internal Medicine, General University Hospital, Prague, Czech Republic
  
  
  RESULTS
  There was no difference in relative hyperaemia index as an endothelial function measure between patients and controls (2.19±0.68 vs. 1.98±0.57, p=NS) and there were also no correlations between reactive hyperaemia index and the traditional CV risk factors, illness duration or psychotic symptoms. On the other hand, the two study groups differed significantly in almost all traditional CV risk factors.
authors.affiliation: Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Dita
authors.initials: D
authors.lastname: Protopopova
authors.affiliation: Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Masopust
authors.affiliation: Department of Cardiovascular Medicine I, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Radovan
authors.initials: R
authors.lastname: Malý
authors.affiliation: Department of Neurology, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Valis
authors.affiliation: 2nd Department of Internal Medicine - Cardiology and Angiology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dostalova
authors.affiliation: 2nd Department of Internal Medicine - Cardiology and Angiology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: Kristina
authors.initials: K
authors.lastname: Ranna
authors.affiliation: Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Bažant
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011618:Psychotic Disorders / Q000453:epidemiology*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers