title: Nerve growth factor promotes human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa.
abstract: Nerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose-dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.
authors.affiliation: Clinical Laboratory Center, General Hospital of Air Force, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Ding
authors.affiliation: National Research Institute of Family Planning, Beijing, China.
authors.forename: Cui-Ge
authors.initials: CG
authors.lastname: Shi
authors.affiliation: People's Hospital of Tibet Autonomous Region, Lassa, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zeng
authors.affiliation: People's Hospital of Tibet Autonomous Region, Lassa, China.
authors.forename: SuoLang
authors.initials: S
authors.lastname: QuZong
authors.affiliation: Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Liu
authors.affiliation: Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: People's Hospital of Tibet Autonomous Region, Lassa, China.
authors.forename: GeSang
authors.initials: G
authors.lastname: LuoBu
authors.affiliation: Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
authors.affiliation: Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Zhao
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D020932:Nerve Growth Factor / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D020932:Nerve Growth Factor
keywords: Assisted reproduction; fertility; in vitro; nerve growth factor; sperm motility