title: Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine.
abstract: To investigate the associations of serum levels of intercellular adhesion molecule-1 (ICAM1) and the pro-inflammatory cytokine interleukin-6 (IL-6) with migraine and migraine subtypes, and to study their correlation with each other in this condition. We used enzyme-linked immunosorbent assay to measure serum levels of ICAM1 and IL-6 in 103 migraine patients with and without aura, in both attack and pain-free periods, and in 100 healthy control subjects. Serum levels of ICAM1 and IL-6 were significantly higher in migraine patients during attacks than in controls (p < 0.05). Serum ICAM1 levels were significantly higher in migraine with aura (MA) than in migraine without aura (MO), (p < 0.05). Correlation analysis indicated a significant positive correlation between serum levels of ICAM1 and IL-6 (p < 0.05) in migraine patients during attacks. Our results indicate that ICAM1 and IL-6 are involved in the pathogenesis of migraine attacks, possibly via an interactive mechanism.
authors.affiliation: Department of Neurology, The People's Hospital of Liaoning Province, No. 33, WenYi Road, Shenhe District, Shenyang, 110016, Liaoning, China.
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Wang
authors.forename: Qiu
authors.initials: Q
authors.lastname: He
authors.forename: Zhanxiu
authors.initials: Z
authors.lastname: Ren
authors.forename: Fuyong
authors.initials: F
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Lin
authors.forename: Hemin
authors.initials: H
authors.lastname: Zhang
authors.forename: Guofeng
authors.initials: G
authors.lastname: Tai
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000145:classification; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1