title: Energy replacement using glucose does not increase postprandial lipemia after moderate intensity exercise.
abstract: BACKGROUND
  Aerobic exercise can decrease postprandial triglyceride (TG) concentrations but the relationship between exercise-induced energy deficits and postprandial lipemia is still unclear. The aim of the present study was to examine the effect of a single bout of aerobic exercise, with and without energy replacement, on postprandial lipemia and on peripheral blood mononuclear cell (PBMC) mRNA expression of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) receptors and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).
  
  
  METHODS
  Nine healthy male humans completed three two-day trials in a random order. On day 1, volunteers rested (CON), completed 60 minutes of treadmill walking at 50% of VO2peak (EX) or completed the same bout of walking but with the energy replaced afterwards with a glucose solution (EXG). On day 2, volunteers rested and consumed a high fat test meal in the morning.
  
  
  RESULTS
  Total and incremental TG AUC were significantly lower on the EXG (P < 0.05) and EX (P < 0.05) trials than the CON trial with no difference between the two exercise trials. No significant difference was observed in VLDL or LDL receptor mRNA expression among the trials (P > 0.05).
  
  
  CONCLUSIONS
  In conclusion, energy replacement by glucose did not affect the decrease in postprandial TG concentrations observed after moderate intensity exercise and exercise does not affect changes in PBMC HMGCR, VLDL and LDL receptor mRNA expression.
authors.forename: Chih-Hui
authors.initials: CH
authors.lastname: Chiu
authors.forename: Stephen Francis
authors.initials: SF
authors.lastname: Burns
authors.forename: Tsung-Jen
authors.initials: TJ
authors.lastname: Yang
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Chang
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Chen
authors.forename: Cheng-Kang
authors.initials: CK
authors.lastname: Chang
authors.affiliation: Graduate Institute of Sports and Health Management, National Chung Hsing University, Taichung, Taiwan. psclw@dragon.nchu.edu.tw.
authors.forename: Ching-Lin
authors.initials: CL
authors.lastname: Wu
mesh_terms: D019540:Area Under Curve; D008076:Cholesterol, HDL / Q000097:blood; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D015870:Gene Expression; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D005082:Physical Exertion; D019518:Postprandial Period; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*; D016138:Walking; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D011973:Receptors, LDL; D014280:Triglycerides; C036053:VLDL receptor; C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases; D005947:Glucose