title: Generalized, severe, chronic periodontitis is associated with anemia of chronic disease: a pilot study in urban, Indian males.
abstract: OBJECTIVE
  Anemia of chronic disease, a cytokine-mediated anemia, is a frequent complication of many chronic inflammatory conditions. The present case-control study was aimed to evaluate levels of systemic hematological markers indicative of anemia in patients with generalized, severe, chronic periodontitis.
  
  
  METHODS
  A convenience quota sample of 30 systemically-healthy, urban, male patients comprised two groups, based on full mouth periodontal examination: group A patients (n=15) were diagnosed with generalized, severe, chronic periodontitis, and group B patients comprised the control group (n=15), which included patients with a clinically-healthy periodontium. Laboratory blood investigations included hemoglobin (g%), total number of erythrocytes (red blood cells), hematocrit/packed cell volume, erythrocyte sedimentation rate, mean corpuscular volume of erythrocytes, and mean corpuscular hemoglobin concentration. An analysis of covariance using age as a covariate was done to compare the mean values of hematological parameters within groups.
  
  
  RESULTS
  The mean values of hemoglobin, red blood cells, packed cell volume, and mean corpuscular hemoglobin concentration were significantly lower, while the mean corpuscular volume of erythrocytes and erythrocyte sedimentation rate were significantly higher in group A patients compared to those in group B, indicating mild anemia.
  
  
  CONCLUSIONS
  Severe periodontal disease can be linked with anemic status.
authors.affiliation: Department of Periodontics and Oral Implantology, Dr D.Y. Patil Dental College and Hospital, Pimpri, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Naik
authors.forename: Aneesha
authors.initials: A
authors.lastname: Acharya
authors.forename: Vijay L
authors.initials: VL
authors.lastname: Deshmukh
authors.forename: Sharath
authors.initials: S
authors.lastname: Shetty
authors.forename: Ravi
authors.initials: R
authors.lastname: Shirhatti
mesh_terms: D000328:Adult; D000367:Age Factors; D000740:Anemia / Q000097:blood*; D001799:Blood Sedimentation; D015992:Body Mass Index; D055113:Chronic Periodontitis / Q000097:blood*; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005247:Feeding Behavior; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood; D010865:Pilot Projects; D014504:Urban Health
chemical_list: D006454:Hemoglobins
keywords: anemia; chronic periodontitis; hemoglobin; inflammation; red blood cell