title: European Bioanalysis Forum: recommendation for dealing with internal standard variability.
abstract: Adequate monitoring of internal standard (IS) response across an analytical run and identification of anomalies is now a common expectation. However, the means to conduct this assessment in an appropriate manner is unclear and differs widely between laboratories. A European Bioanalysis Forum (EBF) topic team was formed to survey current practices within European Bioanalysis Forum member companies and to recommend a best practice approach for dealing with IS response variability.
authors.affiliation: Bioanalytical Science & Toxicokinetics, Drug Metabolism & Pharmacokinetics, GlaxoSmithKline R&D, Ware, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: White
authors.forename: Neil
authors.initials: N
authors.lastname: Adcock
authors.forename: Walid
authors.initials: W
authors.lastname: Elbast
authors.forename: Jim
authors.initials: J
authors.lastname: Hiller
authors.forename: Magnus
authors.initials: M
authors.lastname: Knutsson
authors.forename: Berthold
authors.initials: B
authors.lastname: Lausecker
authors.forename: Jeff
authors.initials: J
authors.lastname: Long
authors.forename: Stuart
authors.initials: S
authors.lastname: McDougall
authors.forename: Fabrice
authors.initials: F
authors.lastname: Salavert
authors.forename: Timothy
authors.initials: T
authors.lastname: Sangster
authors.forename: Tom
authors.initials: T
authors.lastname: Verhaeghe
authors.forename: Peter
authors.initials: P
authors.lastname: van Amsterdam
mesh_terms: D005060:Europe; D006801:Humans; D012107:Research Design