title: Characterization of a novel orthoreovirus isolated from fruit bat, China.
abstract: BACKGROUND
  In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin.
  
  
  RESULTS
  In this report, we isolated a novel Melaka-like reovirus (named "Cangyuan virus") from intestinal content samples of one fruit bat residing in China's Yunnan province. Phylogenetic analysis of the whole Cangyuan virus genome sequences of segments L, M and S demonstrated the genetic diversity of the Cangyuan virus. In contrast to the L and M segments, the phylogenetic trees for the S segments of Cangyuan virus demonstrated a greater degree of heterogeneity.
  
  
  CONCLUSIONS
  Phylogenetic analysis indicated that the Cangyuan virus was a novel orthoreovirus and substantially different from currently known members of Pteropine orthoreovirus (PRV) species group.
authors.forename: Tingsong
authors.initials: T
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Biao
authors.initials: B
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Xiu
authors.initials: X
authors.lastname: Liang
authors.forename: Wendong
authors.initials: W
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Yingguo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yiyin
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Ziliang
authors.initials: Z
authors.lastname: Feng
authors.forename: Yonghe
authors.initials: Y
authors.lastname: Hu
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhou
authors.forename: Changchun
authors.initials: C
authors.lastname: Tu
authors.forename: Quanshui
authors.initials: Q
authors.lastname: Fan
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002681:China; D002685:Chiroptera / Q000821:virology*; D014644:Genetic Variation / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D018165:Orthoreovirus / Q000235:genetics* / Q000302:isolation & purification*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D012367:RNA, Viral