title: Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.
abstract: Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.
authors.affiliation: Department of Pharmacology and Biopharmacy, Doctors Improvement Faculty, Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: V I
authors.initials: VI
authors.lastname: Karamysheva
authors.forename: L B
authors.initials: LB
authors.lastname: Reznikova
authors.forename: I S
authors.initials: IS
authors.lastname: Mokrousov
authors.forename: L I
authors.initials: LI
authors.lastname: Mikhailova
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaya
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006025:Glycosaminoglycans / Q000494:pharmacology; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D051381:Rats; D012965:Sodium Chloride; D013927:Thrombosis / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004151:Dipeptides; D006025:Glycosaminoglycans; D009539:Nicotinic Acids; C000600508:RGPU-151; C000600509:RGPU-152; D012965:Sodium Chloride; D005680:gamma-Aminobutyric Acid; C007858:glucuronyl glucosamine glycan sulfate; C008842:4-amino-3-phenylbutyric acid