title: Asymptomatic Cecal Perforation in a Renal Transplant Recipient After Sodium Polystyrene Sulfonate Administration.
abstract: Sodium polystyrene sulfonate (SPS) is a medication commonly used for the treatment of hyperkalemia. There have been many cases of colonic necrosis and perforation associated with administration of SPS. There are very few such cases reported in renal transplant patients. We present a case of renal transplant recipient who developed cecal perforation after a single oral dose of SPS. She had no signs or symptoms suggestive of intestinal perforation and was incidentally diagnosed with it on abdominal imaging performed to find cause of acute blood loss anemia. This case underlines the importance of recognizing this severe and potentially life-threatening complication associated with SPS. The clinicians should also consider renal/solid organ transplant and immunosuppression as potential risk factors.
authors.affiliation: 1Division of Nephrology, Department of Medicine, Metropolitan Hospital Center, New York Medical College, New York, NY; and 2Department of Endocrinology, SUNY Downstate Medical Center, New York, NY.
authors.forename: Montish
authors.initials: M
authors.lastname: Singla
authors.forename: Deep
authors.initials: D
authors.lastname: Shikha
authors.forename: Sunggeun
authors.initials: S
authors.lastname: Lee
authors.forename: Donald
authors.initials: D
authors.lastname: Baumstein
authors.forename: Ashok
authors.initials: A
authors.lastname: Chaudhari
authors.forename: Roger
authors.initials: R
authors.lastname: Carbajal
mesh_terms: D002411:Cation Exchange Resins / Q000009:adverse effects* / Q000627:therapeutic use; D002432:Cecum / Q000293:injuries*; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy* / Q000209:etiology; D007416:Intestinal Perforation / Q000139:chemically induced*; D016030:Kidney Transplantation / Q000009:adverse effects; D008875:Middle Aged; D011137:Polystyrenes / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D002411:Cation Exchange Resins; D011137:Polystyrenes; C003321:polystyrene sulfonic acid