title: Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation.
abstract: Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(ɛ-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China Department of Cardio-Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lai
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Meidong
authors.initials: M
authors.lastname: Lang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lian
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China guo.changfa@zs-hospital.sh.cn wang.chunsheng@zs-hospital.sh.cn.
authors.forename: Changfa
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China guo.changfa@zs-hospital.sh.cn wang.chunsheng@zs-hospital.sh.cn.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D006334:Heart Function Tests; D020100:Hydrogels; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000628:therapy*; D011108:Polymers / Q000737:chemistry*; D033581:Stem Cell Transplantation
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers
keywords: Copolymer; cardiac repair; hydrogel; mesenchymal stem cells; myocardial infarction