title: Long-term consequences of anesthetic technique after cancer surgery.
abstract: The main treatment for most types of malignant tumors is their surgical removal. During the past years there has been a growing interest in the anesthesia effects on long-term surgery results in connection with cancer. Modern clinical and laboratory data indicate that the anesthetic technique may play a role in tumor dissemination and recurrence. The purpose of this study is to review the available literature data on the anesthetic techniques applied in oncology surgery, long-term consequences of anesthesia/analgesia and their relation to tumor progression.
  
  
  METHODS
  We have reviewed the specialized medical literature and have analyzed the effects of anesthesia/analgesia on long-term results of surgical treatment--incidence of local recurrence, metastases and patients' survival.
  
  
  RESULTS
  The hypothesis about the influence of the anesthesia type on long-term results after cancer surgery is generated. The use of anesthetics and analgesics with low potential for immunosuppression may reduce the relapse. This is a useful approach for patients with cancer.
  
  
  CONCLUSIONS
  Further randomized controlled trials are required for extensive research of this problem.
authors.forename: D
authors.initials: D
authors.lastname: Tzoneva
authors.forename: J
authors.initials: J
authors.lastname: Cherkezov
authors.forename: S
authors.initials: S
authors.lastname: Georgiev
authors.forename: Sv
authors.initials: S
authors.lastname: Masljankov
authors.forename: G
authors.initials: G
authors.lastname: Todorov
mesh_terms: D000698:Analgesia / Q000009:adverse effects / Q000379:methods*; D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology*; D000758:Anesthesia / Q000009:adverse effects / Q000379:methods*; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000494:pharmacology; D009362:Neoplasm Metastasis / Q000276:immunology / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000473:pathology*; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery*
chemical_list: D000700:Analgesics; D000777:Anesthetics; D007166:Immunosuppressive Agents