title: On the cytocompatibility of biodegradable Fe-based alloys.
abstract: Biodegradable iron-based alloys are potential candidates for application as temporary implant material. This study summarizes the design strategy applied in the development of biodegradable Fe-Mn-C-Pd alloys and describes the key factors which make them suitable for medical applications. The study's in vitro cytotoxicity tests using human umbilical vein endothelial cells revealed acceptable cytocompatibility based on the alloys' eluates. An analysis of the eluates revealed that Fe is predominantly bound in insoluble degradation products, whereas a considerable amount of Mn is in solution. The investigation's results are discussed using dose-response curves for the main alloying elements Fe and Mn. They show that it is mainly Mn which limits the cytocompatibility of the alloys. The study also supplies a summary of the alloying elements' influence on metabolic processes. The results and discussion presented are considered important and instructive for future alloy development. The Fe-based alloys developed show an advantageous combination of microstructural, mechanical and biological properties, which makes them interesting as degradable implant material.
authors.affiliation: Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: michael.schinhammer@mat.ethz.ch.
authors.forename: Michael
authors.initials: M
authors.lastname: Schinhammer
authors.affiliation: Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gerber
authors.affiliation: Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Anja C
authors.initials: AC
authors.lastname: Hänzi
authors.affiliation: Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Uggowitzer
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007501:Iron / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D010165:Palladium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008345:Manganese; D010165:Palladium; D002244:Carbon; D007501:Iron