title: [Research and clinical applications regarding endothelial progenitor cell transplantation].
abstract: Endothelial injury or dysfunction leads to multiple cardiovascular diseases, such as atherosclerosis, myocardial infarction, stroke, hypertension and peripheral vascular disease. Endothelial progenitor cells (EPCs) are precursor cells of endothelial cells, including the early endothelial progenitor cells and the late endothelial progenitor cells. These two EPC types have different function and surface markers. EPC in this article mainly means late endothelial progenitors which could grow into endothelial cloning and form vessels in vivo. Late EPCs can express CD133, CD31, KDR, CD144, CD34 etc, take in low density lipoprotein, bind with ulex europaeus lectin 1 and form blood vessels in vitro and in vivo. EPCs not only participate in new blood vessels formation, but also are closely related to the repair of damaged endothelium. Many studies confirm that the transplanted EPCs are able to be mobilized to vascular injury location and repair the damaged endothelial cells thus promote new blood vessel formation, which provides a promising strategy for the treatment of cardiovascular diseases and ischemic diseases.
authors.affiliation: Institute of Reproduction and Stem Cell Engineering, Central South University; National Engineering Research Center of Human Stem Cells, Changsha 410078, China.
authors.forename: Kefang
authors.initials: K
authors.lastname: Tan
authors.forename: Xuan
authors.initials: X
authors.lastname: Sun
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000628:therapy*; D042783:Endothelial Cells; D066026:Endothelial Progenitor Cells; D006801:Humans; D033581:Stem Cell Transplantation
chemical_list: D015415:Biomarkers