title: Effect of hafnium and titanium coated implants on several blood biochemical markers after osteosynthesis in rabbits.
abstract: OBJECTIVE
  An experimental study comparing the dynamics of several biochemical markers before and after osteosynthesis, utilizing implants coated with titanium and hafnium nitrides and non-coated implants on rabbits' bones.
  
  
  METHODS
  The Study has been conducted on 30 rabbits of both sexes, at the age of 6-7 months, weighing 2526.5±74.4 gm. Animals underwent open osteotomy of the tibia in the middle third of the diaphysis followed by the intramedullary nailing. The level of alkaline phosphatase, calcium, phosphorus, total protein, glucose, ALT and AST were monitored for 60 days.
  
  
  RESULTS
  the use of implants coated with titanium and hafnium nitrides, which have high strength, thermal and chemical stability, was not accompanied by the development of additional negative reactive changes compared to non-coated implants.
  
  
  CONCLUSIONS
  Nanotechnology used in manufacturing bioinert coatings for implants for osteosynthesis, has made the post-operative period less complicated as reflected by less expressed changing in the markers of bone metabolism and hepatotoxicity.
authors.affiliation: Department of Orthopedic Surgery, New Mowasat Hospital Salmiya, Kuwait.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Yousef
authors.affiliation: Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia ; Republic Clinical Hospital Kazan, Russia.
authors.forename: Ildar
authors.initials: I
authors.lastname: Akhtyamov
authors.affiliation: Department of Veterinary Surgery, Kazan State Academy of Veterinary Medicine Kazan, Russia.
authors.forename: Faina
authors.initials: F
authors.lastname: Shakirova
authors.affiliation: Department of Pathophysiology, Kazan State Medical University Kazan, Russia.
authors.forename: Lyaili
authors.initials: L
authors.lastname: Zubairova
authors.affiliation: Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia.
authors.forename: Elmira
authors.initials: E
authors.lastname: Gatina
authors.affiliation: Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia.
authors.forename: Capital Ie Cyrilliclchin
authors.initials: CIe
authors.lastname: Aliev
keywords: Implants; bioinert coating; osteosynthesis; titanium and hafnium nitrides