title: Attenuated effects of chitosan-capped gold nanoparticles on LPS-induced toxicity in laboratory rats.
abstract: The impact of nanoparticles in medicine and biology has increased rapidly in recent years. Gold nanoparticles (AuNP) have advantageous properties such as chemical stability, high electron density and affinity to biomolecules. However, the effects of AuNP on human body after repeated administration are still unclear. Therefore, the purpose of the present study was to evaluate the effects of gold-11.68 nm (AuNP1, 9.8 μg) and gold-22.22 nm (AuNP2, 19.7 μg) nanoparticles capped with chitosan on brain and liver tissue reactivity in male Wistar rats exposed to lipopolysaccharide (LPS from Escherichia coli serotype 0111:B4, 250 μg) upon 8 daily sessions of intraperitoneal administration. Our results suggest that the smaller size of chitosan-capped AuNP shows the protective effects against LPS-induced toxicity, suggesting a very high potential for biomedical applications.
authors.affiliation: Department of Biology, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Stefan
authors.affiliation: COMB Laboratory, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.
authors.forename: Viorel
authors.initials: V
authors.lastname: Melnig
authors.affiliation: COMB Laboratory, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pricop
authors.affiliation: Department of Biology, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.
authors.forename: Anca
authors.initials: A
authors.lastname: Neagu
authors.affiliation: Department of Biology, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Mihasan
authors.affiliation: "Gr.T. Popa", University of Medicine and Pharmacy, 16 University Str., Iasi, 700115, Romania.
authors.forename: Liliana
authors.initials: L
authors.lastname: Tartau
authors.affiliation: Department of Biology, "Alexandru Ioan Cuza" University, B-dul Carol I, No. 11, Iasi, 700506, Romania. Electronic address: hritcu@uaic.ro.
authors.forename: Lucian
authors.initials: L
authors.lastname: Hritcu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D010316:Particle Size; D017208:Rats, Wistar; D012996:Solutions; D055672:Static Electricity
chemical_list: D008070:Lipopolysaccharides; D012996:Solutions; D006046:Gold; D048271:Chitosan