title: Dynamics of double strand breaks and chromosomal translocations.
abstract: Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Iarovaia
authors.forename: Mikhail
authors.initials: M
authors.lastname: Rubtsov
authors.forename: Elena
authors.initials: E
authors.lastname: Ioudinkova
authors.forename: Tatiana
authors.initials: T
authors.lastname: Tsfasman
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Razin
authors.affiliation: UMR8126, Université Paris-Sud, CNRS, Institut de cancérologie Gustave Roussy, Villejuif 94805, France. vassetzky@igr.fr.
authors.forename: Yegor S
authors.initials: YS
authors.lastname: Vassetzky
mesh_terms: D004247:DNA / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D012330:RNA, Double-Stranded / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D012330:RNA, Double-Stranded; D004247:DNA