title: Microwave-assisted synthesis of novel 2H-chromene derivatives bearing phenylthiazolidinones and their biological activity assessment.
abstract: 6-Hydroxy-2-oxo-2H-chromene-4-carbaldehyde (2), 6-chloro-2-oxo-2H-chromene-4-carbaldehyde (3) and 6-hydrazinyl-4-methyl-2H-chromen-2-one (5) were prepared as single-pharmacophore motif key intermediates. Compounds 2, 3 and 5 were incorporated in a series of multicomponent reactions (MCRs), under microwave assistance as well as conventional chemical synthesis processes, to afford a series of three and/or four-pharmacophoric-motif conjugates 8a,b, 11, 13, 16, 17, 19 and 20 in good yields. The newly synthesized compounds were characterized by IR, NMR, 13C-NMR, MS and elemental analyses. Finally the synthesized compounds have been screened for their biological activity whereupon they exhibited remarkable antimicrobial activity on different classes of bacteria and the fungus.
authors.affiliation: Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia. ihelmy2003@yahoo.com.
authors.forename: Islam H
authors.initials: IH
authors.lastname: El Azab
authors.affiliation: Chemistry Department, Faculty of Science, Aswan University, Aswan 81528, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Youssef
authors.affiliation: Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia.
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Amin
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002625:Chemistry, Organic / Q000379:methods*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D009570:Nitriles; D053778:Thiazolidines