title: Novel applications of osseointegration in orthopedic limb salvage surgery.
abstract: Osseointegration is a biologic process vital to modern endoprosthetic fixation in orthopedic surgery. Numerous engineering advancements have improved the utilization of this technology in orthopedics; however, issues such as stress shielding, aseptic loosening, and bone loss remain an ongoing challenge. These host responses are especially problematic in limb salvage surgery. Novel applications of osseointegration have been developed to address some of these fixation issues with massive tumor endoprostheses. This articles reviews osseointegration and emerging novel applications of this technology in limb salvage surgery and future prosthetics for amputees.
authors.affiliation: Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT 84112, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Monument
authors.affiliation: Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT 84112, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Lerman
authors.affiliation: Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT 84112, USA. Electronic address: Lor.Randall@hci.utah.edu.
authors.forename: R Lor
authors.initials: RL
authors.lastname: Randall
mesh_terms: D001178:Arthroplasty; D001186:Artificial Limbs; D006801:Humans; D007595:Joint Prosthesis; D023821:Limb Salvage; D016348:Osseointegration; D011474:Prosthesis Design
keywords: Bone loss; Compressive osseointegration; Limb salvage surgery; Revision surgery; Stress shielding; Tumor endoprosthesis