title: Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation.
abstract: A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C-H activation of aldehydes under neat conditions at 50 °C or ball-milling conditions at room temperature.
authors.affiliation: School of Chemical Sciences, National Institute of Science Education and Research (NISER), Institute of Physics Campus, P.O. Sainik School, Bhubaneswar, Odisha 751 005, India.
authors.forename: Tapas Kumar
authors.initials: TK
authors.lastname: Achar
authors.affiliation: School of Chemical Sciences, National Institute of Science Education and Research (NISER), Institute of Physics Campus, P.O. Sainik School, Bhubaneswar, Odisha 751 005, India.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Mal
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002700:Chloramines / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000577:Amides; D002700:Chloramines; D005609:Free Radicals; D000644:Quaternary Ammonium Compounds; D020122:tert-Butylhydroperoxide; C009405:tetrabutylammonium