title: Electrospun polyvinyl alcohol/chitosan composite nanofibers involving Au nanoparticles and their in vitro release properties.
abstract: Au nanoparticles (Au NPs) containing polyvinyl alcohol (PVA)/chitosan (CS) composite nanofibers were successfully prepared by a simple and effective method called electrospinning. Au NPs were firstly synthesized under a mild condition with CS as the reducing agent and stabilizer, followed by being mixed with PVA solution and then the resulting fibers were fabricated. The research indicated that Au NPs were indeed doped into the as-prepared fibers and the composite fibers well preserved Au NPs' unique optical characteristics. Additionally, with the adjustment of the weight ratios between PVA and CS, the diameter distribution and the morphology of the nanofibers were largely changed. In vitro drug release experiments demonstrated that the drug release rate can be conveniently controlled by changing the crosslink time.
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Eryun
authors.initials: E
authors.lastname: Yan
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Fan
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Xunqi
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Functional Inorganic Material Chemistry (Heilongjiang University), Ministry of Education, PR China. Electronic address: wangc_93@yahoo.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Key Laboratory of Functional Inorganic Material Chemistry (Heilongjiang University), Ministry of Education, PR China.
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Key Laboratory of Functional Inorganic Material Chemistry (Heilongjiang University), Ministry of Education, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ni
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D006046:Gold; D004317:Doxorubicin; D011142:Polyvinyl Alcohol; D048271:Chitosan