title: Ischemia/reperfusion Injury and its Consequences on Immunity and Inflammation.
abstract: Ischemia/reperfusion injury (IRI), an inherent component of transplantation, affects organ quality and transplant outcomes. Although the complexity of the pathophysiology is recognized, detailed mechanisms remain unclear, and strategies preventing the consequences of IRI have been challenging. Of critical significance appears the link between IRI, the initiation of innate immune responses, and the (potential) augmentation of adaptive immunity. An improved understanding of those complex mechanisms and interactions may pave the way for more effective treatment strategies.
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School ; Division of Transplant Surgery, Department of Surgery, Erasmus MC-University Medical Center.
authors.forename: Bendix R
authors.initials: BR
authors.lastname: Slegtenhorst
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Erasmus MC-University Medical Center.
authors.forename: Frank Jmf
authors.initials: FJ
authors.lastname: Dor
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School ; Department of Cardiovascular Surgery, University Hospital of Zurich.
authors.forename: Hector
authors.initials: H
authors.lastname: Rodriguez
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School ; Division of Nephrology, Renal Transplant Unit, Department of Medicine, University Medical Center Groningen.
authors.forename: Floris J
authors.initials: FJ
authors.lastname: Voskuil
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School.
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Tullius
keywords: inflammation; innate immunity; ischemia-reperfusion injury