title: Synthesis and antitubercular screening of some novel 4H-1,4- benzothiazines and their sulfones under environment benign solvent free conditions as future anti-tubercular agents.
abstract: Some novel analogs of 4H-1,4-benzothiazines were synthesized under environmentally benign solvent free conditions by one pot oxidative cyclocondensation of substituted 2- aminobenzenthiols with compounds having active methylene group and then converted in to sulfones. These compounds were examined as antitubercular agents against Mycobacterium tuberculosis H37Rv using REMA plate method. The best results have MICs from 6.4 to 8.8 μg/mL, comparable to phenothiazines. IR, NMR and mass spectral investigations are included for structural elucidation.
authors.forename: Anjali
authors.initials: A
authors.lastname: Guleria
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Jangid
authors.forename: Naveen
authors.initials: N
authors.lastname: Gautam
authors.forename: Richa
authors.initials: R
authors.lastname: Lakhotia
authors.forename: Abhay
authors.initials: A
authors.lastname: Chowdhary
authors.affiliation: Department of Chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India. anjali.guleria86@gmail.com.
authors.forename: Dinesh C
authors.initials: DC
authors.lastname: Gautam
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: C446962:1,4-benzothiazine; D000995:Antitubercular Agents; D013450:Sulfones; D013843:Thiazines