title: Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial.
abstract: BACKGROUND
  The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.
  
  
  METHODS
  Participants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.
  
  
  RESULTS
  Thirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).
  
  
  CONCLUSIONS
  Exercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.
  
  
  BACKGROUND
  ANZCTR12608000147381. Date trial registered: 27.03.2008.
authors.affiliation: Clinical and Rehabilitation Sciences, Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia. maritad@uni.sydney.edu.au.
authors.forename: Marita T
authors.initials: MT
authors.lastname: Dale
authors.forename: Zoe J
authors.initials: ZJ
authors.lastname: McKeough
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Munoz
authors.forename: Peter
authors.initials: P
authors.lastname: Corte
authors.forename: Peter T P
authors.initials: PT
authors.lastname: Bye
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Alison
mesh_terms: D000368:Aged; D001195:Asbestosis / Q000503:physiopathology / Q000628:therapy*; D004391:Dust; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance; D006801:Humans; D008297:Male; D008875:Middle Aged; D010995:Pleural Diseases / Q000503:physiopathology / Q000628:therapy*; D011788:Quality of Life; D012829:Silicosis / Q000503:physiopathology / Q000628:therapy*; D016037:Single-Blind Method; D013147:Spirometry; D016138:Walking / Q000502:physiology
chemical_list: D004391:Dust