title: Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
abstract: Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China, hemeian@hotmail.com.
authors.forename: Meian
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authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
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authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
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authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
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authors.forename: Karen L
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authors.lastname: Mohlke
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism and.
authors.forename: Guang
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authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-700, Republic of Korea.
authors.forename: Bok-Ghee
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authors.lastname: Han
authors.affiliation: Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Saw Swee Hock School of Public Health, Department of Medicine, Yong Loo Lin School of Medicine, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore 169857.
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hubei, Wuhan 430030, China.
authors.forename: Tangchun
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authors.lastname: Wu
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
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authors.lastname: Qi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001827:Body Height / Q000235:genetics*; D005202:Asia, Eastern; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017027:Protein Tyrosine Phosphatases / Q000235:genetics; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D017027:Protein Tyrosine Phosphatases