title: The influence of XRCC1 genetic variants on lung cancer susceptibility in Chinese Han population.
abstract: Growing evidence suggests that genetic variants of X-ray repair cross-complementing group 1 proteins (XRCC1) contribute to genetic effects on the development of lung cancer. This case-control study aims to evaluate the genetic effects of XRCC1 c.482C>T and c.1686C>G single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. 391 lung cancer patients and 398 cancer-free controls were enrolled in this study. The genotypes of c.482C>T and c.1686C>G genetic variants were detected by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. The genetic effects on lung cancer susceptibility were evaluated using association analyses by the unconditional logistic regression model. Our data indicated that there were significant differences in the distribution of allelic and genotypic frequencies between lung cancer patients and cancer-free controls. The XRCC1 c.482C>T and c.1686C>G genetic variants were significantly associated with the susceptibility to lung cancer (for c.482C>T, TT versus (vs.) CC: OR=2.14, 95% CI 1.31-3.48, P=0.002; T vs. C: OR=1.37, 95% CI 1.10-1.69, P=0.004; for c.1686C>G, GG vs. CC: OR=2.53, 95% CI 1.46-4.38, P=0.001; G vs. C: OR=1.33, 95% CI 1.06-1.65, P=0.012). These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population.
authors.affiliation: Oncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan Hutong, Dongcheng District, Beijing 100730, People's Republic of China.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Peking Union Medical College, Chinese Academy of Medical Sciences, No. 5 DongDanSanTiao, Dongcheng District, Beijing 100005, People's Republic of China.
authors.forename: Jianjiao
authors.initials: J
authors.lastname: Ni
authors.affiliation: Oncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan Hutong, Dongcheng District, Beijing 100730, People's Republic of China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Oncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan Hutong, Dongcheng District, Beijing 100730, People's Republic of China.
authors.forename: Shuchang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, People's Republic of China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Oncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan Hutong, Dongcheng District, Beijing 100730, People's Republic of China. Electronic address: chunmei_bai@126.com.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Bai
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D060005:Genotyping Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
keywords: Genetic variants; Lung cancer; Molecular biomarkers; Single nucleotide polymorphisms; Susceptibility; XRCC1 gene