title: [Effect and significance of BH3-only protein in targeted therapy of  non-small cell lung cancer].
abstract: Lung cancer is the leading cause of cancer deaths throughout the world. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, promotion of apoptosis in NSCLC is an important part of treatment, but anticancer drugs have the toxic side effects, resistance and other problems. Therefore, the search for new targets of anticancer drugs becomes one of the foci in the treatment of NSCLC. The BH3-only protein plays an important role in activation and communication in apoptosis pathways. BIM is the core member in BH3-only protein family. The target at BIM in the treatment of NSCLC has an irreplaceable role. This paper briefly describes the BCL-2 family and BH3-only pro-apoptotic protein, elaborates the important role of BIM and BH3-only protein in targeted therapy of NSCLC.
authors.affiliation: Department of Pathology, Medical College, Ji'nan University, Guangzhou 510632, China.
authors.forename: Weisong
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Pathology, Medical College, Ji'nan University, Guangzhou 510632, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Pathology, Medical College, Ji'nan University, Guangzhou 510632, China.
authors.forename: Kaishan
authors.initials: K
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D009596:Nitrophenols / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: C501332:ABT-737; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D033681:Mitochondrial Membrane Transport Proteins; D009596:Nitrophenols; D010879:Piperazines; D019253:Proto-Oncogene Proteins c-bcl-2; C581062:RTL10 protein, human; D013449:Sulfonamides