title: Relationship between urodynamic findings and sexual function in multiple sclerosis patients with lower urinary tract dysfunction.
abstract: OBJECTIVE
  Sexual dysfunction (SD) is prevalent in multiple sclerosis (MS) patients and affects quality of life. Furthermore, lower urinary tract dysfunction (LUTD) is common in MS patients. Our aim was to determine the relationship between urodynamic findings and SD in a cohort of MS patients with LUTD.
  
  
  METHODS
  From January 2011 to September 2013, 135 consecutive patients with MS in remission phase and LUTD underwent a first urodynamic examination, according to the International Continence Society criteria. Neurological impairment was assessed using the Expanded Disability Status Scale and SD was investigated with the Female Sexual Function Index (FSFI) or the International Index of Erectile Function (IIEF-15). Multivariate logistic regression analysis was performed to identify predictors of female SD (FSFI < 26.55) or moderate-severe erectile dysfunction (ED) (IIEF-EF ≤ 16), after adjusting for confounding factors including urodynamic findings.
  
  
  RESULTS
  Subjects with maximum detrusor pressure during involuntary detrusor contraction (PdetmaxIDC) ≥20.0 cmH2 O had lower IIEF-EF, IIEF overall satisfaction (IIEF-OS), FSFI-Arousal, FSFI-Lubrication and FSFI-Orgasm. Subjects with maximum cystometric capacity (MCC) ≥135 ml had higher IIEF-EF, intercourse satisfaction (IIEF-IS), orgasmic function (IIEF-OF), sexual desire (IIEF-SD), FSFI-Arousal, FSFI-Lubrication, FSFI-Orgasm, FSFI-Satisfaction and FSFI-Pain. On multivariate logistic regression analysis, PdetmaxIDC ≥20 cmH2 O [odds ratio (OR) 6.7; P < 0.05] and MCC <135 ml (OR 6.80; P < 0.05) were predictors of moderate-severe ED. In a model including all previous variables, compliance ≤3 ml/cmH2 O was an independent predictor of moderate-severe ED (OR 14.49; P < 0.01). No relationship was found between the previous variables and FSFI <26.55.
  
  
  CONCLUSIONS
  Neurogenic bladder is associated with SD in MS patients. The presence of PdetmaxIDC ≥20 cmH2 O, MCC <135 ml and compliance ≤3 ml/cmH2 O may significantly predict the presence of moderate-severe ED.
authors.affiliation: Department of Urology, University of Catania, Catania, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Fragalà
authors.forename: G I
authors.initials: GI
authors.lastname: Russo
authors.forename: A
authors.initials: A
authors.lastname: Di Rosa
authors.forename: R
authors.initials: R
authors.lastname: Giardina
authors.forename: S
authors.initials: S
authors.lastname: Privitera
authors.forename: V
authors.initials: V
authors.lastname: Favilla
authors.forename: T
authors.initials: T
authors.lastname: Castelli
authors.forename: M
authors.initials: M
authors.lastname: Chisari
authors.forename: A
authors.initials: A
authors.lastname: Caramma
authors.forename: F
authors.initials: F
authors.lastname: Patti
authors.forename: S
authors.initials: S
authors.lastname: Cimino
authors.forename: G
authors.initials: G
authors.lastname: Morgia
mesh_terms: D000328:Adult; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology*; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology*; D053201:Urinary Bladder, Overactive / Q000453:epidemiology*; D014563:Urodynamics / Q000502:physiology*
keywords: FSFI; IIEF; LUTD; detrusor overactivity; erectile dysfunction; multiple sclerosis; urodynamic