title: Synthesis of nano-bowls with a Janus template.
abstract: Colloidal particles with two or more different surface properties (Janus particles) are of interest in catalysis, biological imaging, and drug delivery. Eccentric nanoparticles are a type of Janus particle consisting of a shell that envelops the majority of a core particle, leaving a portion of the core surface exposed. Previous work to synthesize eccentric nanoparticles from silica and polystyrene have only used microemulsion techniques. In contrast we report the sol-gel synthesis of eccentric Janus nanoparticles composed of a silica shell around a carboxylate-modified polystyrene core (Janus templates). In addition, we have synthesized nano-bowl-like structures after the removal of the polystyrene core by organic solvent. These Janus templates and nanobowls can be used as a versatile platform for site-specific functionalization or controlled theranostic delivery.
authors.affiliation: Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Mo
authors.affiliation: Dept. of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.|Dept. of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Preston B
authors.initials: PB
authors.lastname: Landon
authors.affiliation: Dept of Nanoengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Chris D
authors.initials: CD
authors.lastname: Emerson
authors.affiliation: Dept of Nanoengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Dept. of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Paula
authors.initials: P
authors.lastname: Anzenberg
authors.affiliation: Dept of Nanoengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Akkiraju
authors.affiliation: Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.|Dept. of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.|Dept. of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: Ratnesh
authors.initials: R
authors.lastname: Lal
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties
chemical_list: D002264:Carboxylic Acids; D011137:Polystyrenes; D012997:Solvents; D012822:Silicon Dioxide