title: Successful treatment of meningeal graft-versus-host disease in a haematopoietic stem cell transplant recipient.
abstract: Graft-versus-host disease (GVHD) of the central nervous system is a rare complication following allogeneic haematopoietic stem cell transplant (HSCT). It is a challenging disease process to confirm as biopsies of the involved tissues can be difficult to obtain safely, the clinical presentation can be non-specific and the differential diagnosis includes infection, drug toxicities, metabolic encephalopathy and disease relapse. We report a case of meningeal graft-versus-host disease in a young woman with relapsed acute myeloid leukaemia after a sibling allogeneic HSCT. The GVHD responded to immunosuppression with resolution of the clinical symptoms and radiological findings and has remained quiescent after a second allogeneic HSCT from an unrelated matched donor.
authors.affiliation: Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney, Australia, torypechey@gmail.com.
authors.forename: Victoria
authors.initials: V
authors.lastname: Pechey
authors.forename: John
authors.initials: J
authors.lastname: Parratt
authors.forename: Linh
authors.initials: L
authors.lastname: Vo
authors.forename: William
authors.initials: W
authors.lastname: Stevenson
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000473:pathology*; D012008:Recurrence; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents