title: Gut endoderm takes flight from the wings of mesoderm.
abstract: The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.
authors.affiliation: 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
authors.forename: Angela C H
authors.initials: AC
authors.lastname: McDonald
authors.affiliation: 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto Ontario M5S 1A8, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: Rossant
mesh_terms: D000818:Animals; D004707:Endoderm / Q000196:embryology*; D005855:Germ Layers / Q000196:embryology*; D024002:HMGB Proteins / Q000378:metabolism*; D008648:Mesoderm / Q000196:embryology*; D009024:Morphogenesis / Q000502:physiology*; D055760:SOXF Transcription Factors / Q000378:metabolism*
chemical_list: D024002:HMGB Proteins; D055760:SOXF Transcription Factors; C511606:Sox17 protein, mouse