title: Quinoline based polymeric drug for biological applications: synthesis, characterization, antimicrobial, and drug releasing studies.
abstract: Novel acrylate monomer of quinoline-based chalcone 1-(4-(7-chloroquinolin-4-ylamino)phenyl) acrylate (CPA) was synthesized using (4-(2-chloroquinolin-5-ylamino)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (CPE) and acryloyl chloride. CPA is characterized by different techniques like IR, (1)H NMR and UV-visible spectrometry techniques. Poly(CPA), poly(CPA-co-AA) and poly(CPA-co-HEA) are prepared by solution polymerization technique using CPA, acrylic acid (AA) and hydroxyethylacrylate (HEA), respectively. The antimicrobial activities of the compounds are tested using four different micro-organisms. In vitro cumulative drug release studies are done using UV visible spectroscopic technique. The molecular weights of these polymers are found to be around 5000 g/mol. The synthesized polymers showed two stages of thermal decomposition temperature centred around 220 and 350 °C, respectively. The antimicrobial activity of the polymer sample is found to be very high and especially for gram-negative bacteria with a minimum value of 3.91 μg/mL. The in vitro drug-releasing rate is dependent on the comonomer, pH and temperature of the medium.
authors.affiliation: a PG & Research Department of Chemistry , Government Arts College , Thiruvannamalai 606603 , Tamil Nadu , India.
authors.forename: P
authors.initials: P
authors.lastname: Uma
authors.forename: J
authors.initials: J
authors.lastname: Suresh
authors.forename: Revathy
authors.initials: R
authors.lastname: Selvaraj
authors.forename: S
authors.initials: S
authors.lastname: Karthik
authors.forename: A
authors.initials: A
authors.lastname: Arun
mesh_terms: D000179:Acrylates / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D001409:Bacillus cereus / Q000187:drug effects; D002599:Chalcone / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D008970:Molecular Weight; D066244:Proton Magnetic Resonance Spectroscopy; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature
chemical_list: D000179:Acrylates; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D011804:Quinolines; D002599:Chalcone; C026200:acryloyl chloride; C037219:quinoline; C036658:acrylic acid
keywords: acrylate; antimicrobial activity; chalcone; drug releasing study