title: Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a case-control study and meta-analysis.
abstract: BACKGROUND
  Cyclin D1 (CCND1) plays a key role in cell cycle regulation. It is a well-established human oncogene which is frequently amplified or overexpressed in cancers. The association between CCND1 G870A polymorphism and cancer risk has been widely assessed. However, a definitive conclusion between CCND1 G870A polymorphism and risk of nasopharyngeal carcinoma (NPC) remains elusive.
  
  
  METHODS
  We firstly performed a hospital-based case-control study involving 165 NPC cases and 191 cancer-free controls in central-south China, and then conducted a meta-analysis with six case-control studies to evaluate the association between NPC risk and CCND1 G870A polymorphism.
  
  
  RESULTS
  The case-control study found a significant association between CCND1 G870A polymorphism and NPC risk in various comparison models (AA vs. GG: OR = 2.300, 95% CI 1.089-4.857, p = 0.029; AG vs. GG: OR = 2.832, 95% CI 1.367-5.867, p = 0.005; AA/AG vs. GG: OR = 2.597, 95% CI 1.288-5.237, p = 0.008; AA vs.
  OR = 0.984, 95% CI 0.638-1.518, p = 0.944). Further meta-analysis showed that there was no significant association between CCND1 G870A polymorphism and NPC risk in overall analysis. In the stratified analysis by race, however, significant associations were only found in Caucasians (for the allele model A vs. G: OR = 0.75, 95% CI 0.59-0.97, p = 0.03; for the co-dominant model AA vs. GG: OR = 0.52, 95% CI 0.32-0.86, p = 0.01; for the dominant model AA/AG vs. GG: OR = 0.49, 95% CI 0.32-0.74, p<0.01; for the recessive model AA vs.
  OR = 0.90, 95% CI 0.61-1.34, p = 0.60).
  
  
  CONCLUSIONS
  A significant association between CCND1 G870A polymorphism and NPC risk was found in the central-southern Chinese population. The meta-analysis indicated that CCND1 G870A polymorphism may contribute to the development of NPC in Caucasians.
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liao
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Yongfu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Medical Oncology, Hunan Tumor Hospital, Changsha, China.
authors.forename: Xingxiang
authors.initials: X
authors.lastname: Pu
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Shengqun
authors.initials: S
authors.lastname: Luo
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: BinBin
authors.initials: B
authors.lastname: Li
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Ding
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China, and Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D016022:Case-Control Studies; D002681:China; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1