title: Structural brain lesions and restless legs syndrome: a cross-sectional population-based study.
abstract: OBJECTIVE
  To evaluate the association between white matter lesion (WML) volume, silent infarcts and restless legs syndrome (RLS) in a population-based study of elderly individuals.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Population-based Three-City study.
  
  
  METHODS
  1035 individuals from the Dijon, France, centre of the Three-City study who had available information on volume of WMLs from MRIs and who answered questions about the prevalence of RLS.
  
  
  METHODS
  Prevalence of RLS.
  
  
  RESULTS
  WML volume was measured using an automated tissue segmentation method. Logistic regression was used to evaluate adjusted associations between tertiles of WML volume and RLS and between silent infarcts and RLS. 218 individuals (21.1%) were determined to have RLS. Compared with those in the first tertile of WML volume, individuals in the second tertile (OR=1.09; 95% CI 0.75 to 1.60) or third tertile (OR=1.17; 95% CI 0.79 to 1.74) did not have an increased prevalence of RLS. We also did not observe associations between the volume of deep or periventricular WML and RLS; nor did we observe an association between silent brain infarcts and RLS (OR=0.74; 95% CI 0.40 to 1.39). These findings were not modified by age or gender.
  
  
  CONCLUSIONS
  Higher volume of WML and the presence of silent infarcts were not associated with an increased prevalence of RLS in this population-based cohort of elderly individuals.
authors.affiliation: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Rist
authors.affiliation: INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.affiliation: Social and Occupational Determinants of Health, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France Université de Versailles St-Quentin, Versailles, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
authors.affiliation: INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France.
authors.forename: Aïcha
authors.initials: A
authors.lastname: Soumaré
authors.affiliation: INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.affiliation: College of Health Sciences, University of Bordeaux, Bordeaux, France CNRS CEA (UMR5296) Neurofunctional Imaging Group, University of Bordeaux, Bordeaux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
authors.affiliation: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France.
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000150:complications* / Q000473:pathology*; D008137:Longitudinal Studies; D008297:Male; D009929:Organ Size; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000150:complications* / Q000453:epidemiology*
keywords: MRI; restless legs syndrome