title: The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview.
abstract: Over one hundred diseases related to inherited defects of complex lipids synthesis and remodeling are now reported. Most of them were described within the last 5 years. New descriptions and phenotypes are expanding rapidly. While the associated clinical phenotype is currently difficult to outline, with only a few patients identified, it appears that all organs and systems may be affected. The main clinical presentations can be divided into (1) Diseases affecting the central and peripheral nervous system. Complex lipid synthesis disorders produce prominent motor manifestations due to upper and/or lower motoneuron degeneration. Motor signs are often complex, associated with other neurological and extra-neurological signs. Three neurological phenotypes, spastic paraparesis, neurodegeneration with brain iron accumulation and peripheral neuropathies, deserve special attention. Many apparently well clinically defined syndromes are not distinct entities, but rather clusters on a continuous spectrum, like for the PNPLA6-associated diseases, extending from Boucher-Neuhauser syndrome via Gordon Holmes syndrome to spastic ataxia and pure hereditary spastic paraplegia; (2) Muscular/cardiac presentations; (3) Skin symptoms mostly represented by syndromic (neurocutaneous) and non syndromic ichthyosis; (4) Retinal dystrophies with syndromic and non syndromic retinitis pigmentosa, Leber congenital amaurosis, cone rod dystrophy, Stargardt disease; (5) Congenital bone dysplasia and segmental overgrowth disorders with congenital lipomatosis; (6) Liver presentations characterized mainly by transient neonatal cholestatic jaundice and non alcoholic liver steatosis with hypertriglyceridemia; and (7) Renal and immune presentations. Lipidomics and molecular functional studies could help to elucidate the mechanism(s) of dominant versus recessive inheritance observed for the same gene in a growing number of these disorders.
authors.affiliation: Department of Neurology, Neurometabolic Unit, Hospital Sant Joan de Déu and CIBERER, ISCIII, Barcelona, Spain, agarcia@hsjdbcn.org.
authors.forename: Àngels
authors.initials: À
authors.lastname: Garcia-Cazorla
authors.forename: Fanny
authors.initials: F
authors.lastname: Mochel
authors.forename: Foudil
authors.initials: F
authors.lastname: Lamari
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Saudubray
mesh_terms: D001259:Ataxia / Q000175:diagnosis; D001848:Bone Diseases, Developmental / Q000175:diagnosis; D005234:Fatty Liver / Q000175:diagnosis; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis; D007057:Ichthyosis / Q000175:diagnosis; D007565:Jaundice / Q000175:diagnosis; D057130:Leber Congenital Amaurosis / Q000175:diagnosis; D008052:Lipid Metabolism, Inborn Errors / Q000175:diagnosis* / Q000235:genetics; D008055:Lipids / Q000737:chemistry*; D008068:Lipomatosis / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis; D008268:Macular Degeneration / Q000175:diagnosis; D019636:Neurodegenerative Diseases / Q000175:diagnosis; D020336:Paraparesis, Spastic / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis; D010641:Phenotype; D058499:Retinal Dystrophies / Q000175:diagnosis; D012174:Retinitis Pigmentosa / Q000175:diagnosis; D015419:Spastic Paraplegia, Hereditary / Q000175:diagnosis; D000080362:Stargardt Disease
chemical_list: D008055:Lipids