title: [Hypotensive effect of extract of macerated garlic (Allium sativum) for 18 weeks in an in vivo experimental model].
abstract: OBJECTIVE
  Determine whether macerated extract of garlic (Allium sativum) for 18 weeks is equal to or better than Captopril in its hypotensive effect in rats.
  
  
  METHODS
  We performed an experimental in vivo study with Holtzman male rats divided into five groups using 100, 500 and 1,000 mg kg of garlic extract, Captopril 100 mg/kg and a vehicle group. 50 mg/kg L-NAME (NG-nitro-L-arginine methyl ester) was administered intraperitoneally which elevated blood pressure after the third day. Statistical analysis consisted of Students t-test for paired means, ANOVA and Scheffe multiple comparison.
  
  
  RESULTS
  The macerated garlic extracted by a hydroalcoholic process administered for 18 weeks resulted in a decrease in blood pressure in experimental animals. In the analysis of treatments on mean arterial pressure (MAP), significant differences were obtained after the third day. The comparison of the MAP final versus MAP basal (no difference in averages) and the hypotensive effect (%) were: garlic-100 (p=0.008), 59.8%; ajo-500 (p=0.021), 80.6%; garlic-1000 (p=0.034), 88.5%; captopril (p=0.437), 99.9%; and vehicle-only (p=0.001), 0%.
  
  
  CONCLUSIONS
  The macerated garlic given for an 18-week period effectively produced a hypotensive effect in rats with hypertension induced by L-NAME.
authors.affiliation: Escuela de Tecnología Médica, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: David
authors.initials: D
authors.lastname: Chaupis-Meza
authors.affiliation: Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
authors.forename: Juan
authors.initials: J
authors.lastname: Rojas
authors.affiliation: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Manuel
authors.initials: M
authors.lastname: Gasco
authors.affiliation: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Gonzales
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D005737:Garlic; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D010936:Plant Extracts