title: A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease.
abstract: Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is the manifestation of immune dysregulation. It is associated with ineffective but exaggerated immune response and infiltration of active lymphocytes and histiocytes in various organs. This devastating clinical condition has myriad of clinical and biochemical manifestations such as fever, splenomegaly, pancytopenia, hypertrygliceridemia, and hyperferritinemia. It can be either primary or secondary. Primary HLH usually presents in childhood. Secondary HLH occurs due to infection mostly viruses but other aetiologies are also important as early detection and treatment may improve survival. Hemophagocytosis due to tuberculosis is uncommon. Only handful of cases have been reported mostly in immunocompromised patients. We report a case of hemophagocytic syndrome associated with disseminated tuberculosis in an immunocompetent women highlighting early diagnosis and treatment is a demanding need in this devastating disease.
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Singha
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, India.
authors.forename: Adreesh
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, India.
authors.forename: Riddhi
authors.initials: R
authors.lastname: Dasgupta
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, India.
authors.forename: Tapas
authors.initials: T
authors.lastname: Das