title: Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies.
abstract: Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.
authors.affiliation: Department of Pediatrics, BC Children's Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada.
authors.forename: Kanwaldeep
authors.initials: K
authors.lastname: Mallhi
authors.affiliation: Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA.
authors.forename: Lawrence G
authors.initials: LG
authors.lastname: Lum
authors.affiliation: Department of Pediatrics, BC Children's Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada. Electronic address: kschultz@mail.ubc.ca.
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Schultz
authors.affiliation: Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Yankelevich
mesh_terms: D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease / Q000276:immunology; D020350:Graft vs Tumor Effect / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Adolescents; Cancer; Cellular therapy; Children; Hematopoietic cell transplantation