title: Simple way to obtain pH-sensitive drug release from functional mesoporous silica materials.
abstract: A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15, calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO4-SBA-15) were synthesised using solvent evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials. They show the large surface are, high pore volume and uniform pore size. Metformin hydrochloride was used as the model drug, and the control release behaviour was investigated. The functional mesoporous silica materials show the pH sensitive drug release behaviour because of the adjustable interaction between the drug molecule and the host.
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Liru
authors.initials: L
authors.lastname: Cui
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, People's Republic of China. qufengyu2013@gmail.com.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Qu
mesh_terms: D002118:Calcium / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D010710:Phosphates; C509969:SBA-15; D012822:Silicon Dioxide; D002118:Calcium