title: Focusing National Institutes of Health HIV/AIDS research for maximum population impact.
abstract: Progress in advancing research on the pathophysiology, prevention, treatment, and impact of human immunodeficiency virus (HIV) is threatened by the decaying purchasing power of National Institutes of Health (NIH) dollars. A working group of the NIH Office of AIDS Research Advisory Council was charged by the NIH Director with developing a focused and concise blueprint to guide the use of limited funding over the next few years. Science priorities outlined by the working group and reported here are intended to maximally address individuals, groups, and settings most affected by the epidemic, and to redress shortcomings in realizing population-level HIV prevention, treatment, and eradication goals. Optimizing these priorities requires that traditional silos--defined by topic focus and by scientific discipline--be dissolved and that structural issues affecting the pipeline of new investigators and the ability of the Office of AIDS Research to fulfill its role of steward of the NIH HIV/AIDS research program be directly addressed.
authors.affiliation: Divisions of Infectious Disease and General Medicine and the Medical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital Division of Infectious Disease, Brigham and Women's Hospital Harvard University Center for AIDS Research, Harvard Medical School, Boston, Massachusetts.
authors.forename: Rochelle P
authors.initials: RP
authors.lastname: Walensky
authors.affiliation: Center for AIDS Prevention Studies, Division of Medicine, School of Medicine, University of California, San Francisco.
authors.forename: Judith D
authors.initials: JD
authors.lastname: Auerbach
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D035843:Biomedical Research / Q000191:economics* / Q000639:trends; D005380:Financing, Government; D015658:HIV Infections / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D009316:National Institutes of Health (U.S.) / Q000191:economics* / Q000458:organization & administration; D012109:Research Support as Topic; D014481:United States
keywords: AIDS; HIV; National Institutes of Health (NIH); research