title: Slicing, sampling, and distance-dependent effects affect network measures in simulated cortical circuit structures.
abstract: The neuroanatomical connectivity of cortical circuits is believed to follow certain rules, the exact origins of which are still poorly understood. In particular, numerous nonrandom features, such as common neighbor clustering, overrepresentation of reciprocal connectivity, and overrepresentation of certain triadic graph motifs have been experimentally observed in cortical slice data. Some of these data, particularly regarding bidirectional connectivity are seemingly contradictory, and the reasons for this are unclear. Here we present a simple static geometric network model with distance-dependent connectivity on a realistic scale that naturally gives rise to certain elements of these observed behaviors, and may provide plausible explanations for some of the conflicting findings. Specifically, investigation of the model shows that experimentally measured nonrandom effects, especially bidirectional connectivity, may depend sensitively on experimental parameters such as slice thickness and sampling area, suggesting potential explanations for the seemingly conflicting experimental results.
authors.affiliation: Department of Neuroscience, Frankfurt Institute for Advanced Studies Frankfurt am Main, Germany.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Miner
authors.affiliation: Department of Neuroscience, Frankfurt Institute for Advanced Studies Frankfurt am Main, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Triesch
keywords: common neighbor; cortical networks; cortical slices; graph theory; motifs; network topology; nonrandom connectivity