title: Pharmaceutical interventions in prescriptions for patients admitted with chronic renal failure.
abstract: BACKGROUND
  Chronic Renal Failure (CRF) is a disease that requires determined medications dosages to be adjusted.
  
  
  OBJECTIVE
  To assess the characteristics of pharmaceutical interventions concerning the dose adjustment of these drugs in patients with CRF who are admitted into hospital.
  
  
  METHODS
  A 10-month prospective and longitudinal study that calculated the glomerular filtration rate of patients who are brought into the emergency department and had values below 50ml/min/1.73m2. Subsequently, dosage recommendations were provided for the drugs that had not been adapted to the patient&rsquo;s renal function.
  
  
  RESULTS
  The renal functions of 5311 patients were reviewed. One-hundred and eighty-one (3.4%) had a glomerular filtration rate below 50ml/min/1.73m2 and were receiving drugs that needed to be adjusted. 221 interventions were recorded. Reductions in dosages were the more frequent results (65.6%); 65.6% of these recommendations were accepted by the doctor. The antimicrobial group had the highest number of interventions (57.5%). Internal Medicine (50.2%) was the unit with the most interventions.
  
  
  CONCLUSIONS
  CRF patients that are admitted into the emergency department are a key objective concerning dosages in chronic renal failure. Pharmaceutical recommendations are highly esteemed by doctors, given their high acceptance. Revising antimicrobial drugs offers more opportunities.
authors.forename: Paula
authors.initials: P
authors.lastname: Arrabal-Durán
authors.forename: M Esther
authors.initials: ME
authors.lastname: Durán-García
authors.forename: Almudena
authors.initials: A
authors.lastname: Ribed-Sánchez
authors.forename: Patricia
authors.initials: P
authors.lastname: Hidalgo-Collazos
authors.forename: María
authors.initials: M
authors.lastname: Sanjurjo-Sáez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054796:Drug Dosage Calculations; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004630:Emergencies; D004636:Emergency Service, Hospital; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010599:Pharmacokinetics; D011446:Prospective Studies; D062606:Tertiary Care Centers