title: Prognostic factors for mortality in patients hospitalized with influenza complications, in Taiwan.
abstract: BACKGROUND
  This study aims to assess factors associated with fatal hospitalized influenza with complications in Taiwan.
  
  
  METHODS
  We identified reports of complications and illness onset in patients hospitalized with influenza between week 26, 2009 and week 25, 2012 from the National Notifiable Disease Surveillance System. We used a multivariate logistic regression model to evaluate covariates that can be associated with in-hospital mortality.
  
  
  RESULTS
  Among 4735 patients (413 deaths), age ≥50 years (p<0.001), male (p=0.014), comorbidities (p<0.001), and delayed oseltamivir treatment (p<0.001) increased the likelihood of in-hospital mortality.
  
  
  CONCLUSIONS
  We recommend influenza vaccination and early antiviral treatment for at-risk populations.
authors.affiliation: Taiwan Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan muagi@cdc.gov.tw.
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Huang
authors.affiliation: Taiwan Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Chih-Hsi
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Taiwan Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Hsu
authors.affiliation: Taiwan Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan Institute of Biomedical Informatics & Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Jen-Hsiang
authors.initials: JH
authors.lastname: Chuang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000401:mortality*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir
keywords: Case fatality rate; Influenza; Mortality determinant; Surveillance; Taiwan