title: Tonic effects of the dopaminergic ventral midbrain on the auditory cortex of awake macaque monkeys.
abstract: This study shows that ongoing electrical stimulation of the dopaminergic ventral midbrain can modify neuronal activity in the auditory cortex of awake primates for several seconds. This was reflected in a decrease of the spontaneous firing and in a bidirectional modification of the power of auditory evoked potentials. We consider that both effects are due to an increase in the dopamine tone in auditory cortex induced by the electrical stimulation. Thus, the dopaminergic ventral midbrain may contribute to the tonic activity in auditory cortex that has been proposed to be involved in associating events of auditory tasks (Brosch et al. Hear Res 271:66-73, 2011) and may modulate the signal-to-noise ratio of the responses to auditory stimuli.
authors.affiliation: Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany. Ying.Huang@lin-magdeburg.de.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany. Judith.Mylius@lin-magdeburg.de.
authors.forename: Judith
authors.initials: J
authors.lastname: Mylius
authors.affiliation: Emeritus Group Lifelong Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany.|Center for Behavioral Brain Sciences, Otto-von-Guericke-University, Universitätsplatz 2, 39106, Magdeburg, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Scheich
authors.affiliation: Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany.|Center for Behavioral Brain Sciences, Otto-von-Guericke-University, Universitätsplatz 2, 39106, Magdeburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Brosch
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D005072:Evoked Potentials, Auditory; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D014851:Wakefulness
chemical_list: D004298:Dopamine
keywords: Auditory cortex; Deep brain stimulation; Dopamine; Primate; Ventral tegmental area