title: Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3).
abstract: High-sensitivity C-reactive protein (hs-CRP) levels in European populations are lower in patients with maturity-onset diabetes of the young type 3 (MODY3) than in those with type 2 diabetes. hs-CRP levels have been suggested to be useful for discriminating MODY3 from type 2 diabetes. As hs-CRP levels are influenced by various factors including race and body mass index, it is worthwhile to examine whether hs-CRP can serve as a biomarker for MODY3 in Japanese. Here we describe the case of a Japanese MODY3 patient with a nonsense mutation in the HNF1A gene. Two measurements showed consistently lower hs-CRP levels (<0.05 and 0.09 mg/L) than in Japanese patients with type 1 and type 2 diabetes. Hepatic expression of Crp messenger ribonucleic acid was significantly decreased in Hnf1a knockout mice. The hs-CRP level might be a useful biomarker for MODY3 in both Japanese and European populations.
authors.affiliation: Department of Medical Biochemistry Faculty of Life Sciences Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan ; Division of Endocrinology and Metabolism Kurume University School of Medicine Kurume Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ohki
authors.affiliation: Department of Medicine Nissay Hospital Osaka Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Utsu
authors.affiliation: Department of Medicine Nissay Hospital Osaka Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Morita
authors.affiliation: Department of Medical Biochemistry Faculty of Life Sciences Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan.
authors.forename: Md Fazlul
authors.initials: MF
authors.lastname: Karim
authors.affiliation: Department of Medical Biochemistry Faculty of Life Sciences Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Medical Biochemistry Faculty of Life Sciences Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshizawa
authors.affiliation: Division of Developmental Genetics Center for Animal Resources and Development Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Yamamura
authors.affiliation: Division of Endocrinology and Metabolism Kurume University School of Medicine Kurume Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Department of Medicine Nissay Hospital Osaka Japan.
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
authors.affiliation: Department of Medical Biochemistry Faculty of Life Sciences Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamagata
keywords: Hepatocyte nuclear factor 1α; High‐sensitivity C‐reactive protein; Maturity‐onset diabetes of the young type 3