title: Neuroprotective effect of RYGB in Zucker fatty diabetic rats.
abstract: The aim of this study is to explore the therapeutic potential of RYGB, a common used bariatric surgery, on diabetic polyneuropathy (DPN) in streptozotocin (STZ)-induced diabetic rats. In animal model experiments, rats were made diabetic by STZ administration, and after 12 weeks of diabetes, two groups were studied: RYGB and sham surgery control (PF). Change in oral glucose tolerance, insulin sensitivity, and the plasma concentrations of insulin, glucagon, glucagon-like peptide-1 (GLP-1) were measured. Peripheral nerve function was determined by the current perception threshold. Sciatic nerve blood flow (SNBF) and intraepidermal nerve fiber densities (IENFDs) also were evaluated. The results indicated that glucose tolerance and insulin sensitivity were significantly improved in the RYGB group. Fasting total GLP-1 were increased in the RYGB group. The increase seen in current perception threshold vales in RYGB group was reduced. The decreased IENFDs in sole skins of RYGB group were ameliorated by RYGB. In conclusion, the findings indicate that RYGB ameliorates the severity of DPN, which may be associated with increased GLP-1 and improved insulin sensitivity/action.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhengzhou University Zhengzhou 450052, China ; Department of Neurology, Kaifeng Central Hospital Kaifeng 475000, China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Han
authors.affiliation: Department of Neurology, Kaifeng Central Hospital Kaifeng 475000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Neurology, Kaifeng Central Hospital Kaifeng 475000, China.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Jing
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University No. 58, Second Zhongshang Road, Guangzhou 510080, China.
authors.forename: Ai-Wu
authors.initials: AW
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Southern Medical University No. 183, Zhongshan Road West, Guangzhou 510630, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhengzhou University Zhengzhou 450052, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Xu
keywords: Roux-en-Y gastric bypass; diabetes; glucagon-like peptide-1; insulin sensitivity