title: Recent advances in proteomically subtyping pancreatic ductal adenocarcinomas and their potential clinical impact.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a median overall survival of 6 months. Late diagnosis due to the absence of specific symptoms during disease development, in addition to extensive metastatic potential and resistance to chemotherapy and radiotherapy, are the most important reasons for short survival. Research efforts have therefore been focused on the development of early disease detection. However, the only US FDA-approved clinical biomarker, CA19-9, is considered inapplicable for screening and/or early detection of PDAC. The following editorial provides the reader with a short introduction to the topic of PDAC and gives focus to the current state of proteomic research in the field of PDAC biomarker discovery. This editorial also highlights the efforts made to subdivide this tumor entity and the potential clinical impact of patient stratification. Finally, the author provides opinions on the impact of proteomics to PDAC subtype stratification over the next 5 years.
authors.affiliation: Junior Research Group Biomarker Discovery, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Roesli
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome
keywords: clinical impact; pancreatic ductal adenocarcinoma; proteomics; subtype stratification; tumor heterogeneity