title: Advances in paediatric pulmonary vascular disease associated with bronchopulmonary dysplasia.
abstract: Pulmonary hypertension (PH) is a common finding in infants with bronchopulmonary dysplasia (BPD). The aim of this review is to describe recent advances in the diagnosis and treatment of PH and discuss whether they will benefit infants and children with BPD related PH. Echocardiography remains the mainstay of diagnosis but has limitations, further developments in diagnostic techniques and identification of biomarkers are required. There are many potential therapies for PH associated with BPD. Inhaled nitric oxide has been shown to improve short term outcomes only. Sidenafil in resource limited settings was shown in three randomized trials to significantly reduce mortality. The efficacy of other therapies including prostacyclin, PDE3 inhibitors and endothelin receptor blockers has only been reported in case reports or case series. Randomized controlled trials with long term follow up are required to appropriately assess the efficacy of therapies aimed at improving the outcome of children with PH.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, England, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rossor
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
mesh_terms: D000280:Administration, Inhalation; D000367:Age Factors; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D062186:Arterial Pressure / Q000187:drug effects; D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D016896:Treatment Outcome; D066253:Vascular Remodeling / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers
keywords: bronchopulmonary dysplasia; pulmonary hypertension; pulmonary vascular disease