title: [Expression of β-catenin and HNF-1α and their influence on prognosis in human hepatocellular carcinoma].
abstract: OBJECTIVE
  To study the expressions of β-catenin in hepatocellular carcinoma (HCC) tissue, adjacent cirrhotic liver tissue and hemangioma-surrounding liver tissue to understand whether their difference in expression will influence on the prognosis and to study the relationship between Wnt/β-catenin signaling pathway and HNF-1α expression.
  
  
  METHODS
  50 specimens of HCC, 50 specimens of adjacent cirrhotic liver tissue and 7 specimens of hemangioma-surrounding liver tissue were used to detect the differences in the expression of β-catenin and HNF-1α in them by immunohistochemistry.
  
  
  RESULTS
  The expression rate of β-catenin was 74.0% (37/50) in the HCC tissue, 18.0% (9/50) in cirrhotic liver tissue, and 14.3% (1/7) in hemangioma-surrounding liver tissue. The expression rate of β-catenin in HCC tissue was significantly higher than that in the hemangioma-surrounding liver tissue (P = 0.002) and cirrhotic liver tissue (P < 0.001). The patients with abnormal expression had worse prognosis. Among the 50 HCC cases, the expression of HNF-1α was negative in 20.0% (10/50), weak positive in 40.0% (20/50), moderately positive in 26.0% (13/50), and strong positive in 14.0% (7/50). Among the 50 adjacent cirrhotic liver tissues, the expression of HNF-1α was negative in 12.0% (6/50), weak positive in 20.0% (10/50), moderately positive in 52.0% (26/50) and strong positive in 16.0% (8/50). In the 7 cases of hemangioma-surrounding liver tissue, the expression of HNF-1α was negative in 0(0/7), weak positive in 14.3% (1/7), moderately positive in 28.6% (2/7) and strong positive in 57.1% (4/7). The positive expression rate of HNF-1α in the HCC tissue was significantly lower than that in the hemangioma-surrounding liver tissues (P = 0.029) and adjacent cirrhotic liver tissues (P = 0.008). The patients with positive HNF-1α expression had a better prognosis. The abnormal expression of β-catenin was negatively correlated with positive HNF-1α expression (r = -0.673, P < 0.001).
  
  
  CONCLUSIONS
  The occurrence and development of HCC is related to the abnormal β-catenin expression. There is a negative correlation between Wnt/β-catenin signaling pathway and HNF-1α expression.
authors.affiliation: Department of Gastroenterology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China.Email: yinfei_4y@sina.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000378:metabolism; D006391:Hemangioma; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D051538:Hepatocyte Nuclear Factor 1-alpha; D051176:beta Catenin