title: Non-lamellar lipid liquid crystalline structures at interfaces.
abstract: The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in biomedical devices for analyses and drug delivery, it is crucial to understand how they interact with and respond to different types of interfaces. Such non-lamellar interfacial layers can be used to entrap functional biomolecules that respond to lipid curvature as well as the confinement. It is also important to understand the structural changes of deposited lipid in relation to the corresponding bulk dispersions. They can be controlled by changing the lipid composition or by introducing components that can alter the curvature or by deposition on nano-structured surface, e.g. vertical nano-wire arrays. Progress in the area of liquid crystalline lipid based nanoparticles opens up new possibilities for the preparation of well-defined surface films with well-defined nano-structures. This review will focus on recent progress in the formation of non-lamellar dispersions and their interfacial properties at the solid/liquid and biologically relevant interfaces.
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, POB 124, 221 00 Lund, Sweden.
authors.forename: Debby P
authors.initials: DP
authors.lastname: Chang
authors.affiliation: Camurus AB, Ideon Science Park, Gamma Building, Sölvegatan 41, SE-22379 Lund, Sweden; Biomedical Science, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden.
authors.forename: Justas
authors.initials: J
authors.lastname: Barauskas
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, POB 124, 221 00 Lund, Sweden; The Nanometer Structure Consortium (nmC@LU), Lund University, P.O. Box 118, SE-22100 Lund, Sweden.
authors.forename: Aleksandra P
authors.initials: AP
authors.lastname: Dabkowska
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, POB 124, 221 00 Lund, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Wadsäter
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, POB 124, 221 00 Lund, Sweden; Camurus AB, Ideon Science Park, Gamma Building, Sölvegatan 41, SE-22379 Lund, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Tiberg
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, POB 124, 221 00 Lund, Sweden; The Nanometer Structure Consortium (nmC@LU), Lund University, P.O. Box 118, SE-22100 Lund, Sweden. Electronic address: Tommy.Nylander@fkem1.lu.se.
authors.forename: Tommy
authors.initials: T
authors.lastname: Nylander
mesh_terms: D000327:Adsorption; D050866:Liquid Crystals / Q000737:chemistry*; D008567:Membranes, Artificial; D053758:Nanoparticles / Q000737:chemistry; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial
keywords: Cubosomes; Drug delivery; Interfacial properties; Lipid liquid crystalline structure; Liquid crystalline nanoparticles