title: On-going elucidation of mechanisms of primate specific synaptic spine development using the common marmoset (Callithrix jacchus).
abstract: Recently, pathophysiology of human psychiatry originates from abnormal numbers of synapses/spines. There are generally two-types of development of spines from birth depending on species. One is, after birth, synaptogenesis occurs, and there is a clear peak of spines, and then rapidly pruning occurring, which are called "overshoot-type" of development of synapses/spines. Primates including human belong to this type. In other type including rodents, even after a peak, general number of spines does not decrease so much. Although these differences, most of human psychiatric models have been genetic modified rodents. Now, transgenic primate (the common marmoset) became available. In near future, we can, examine pathophysiology of psychiatric disorders using this animal model, which is closer to human being. To begin with this endeavor, we should know how synapses/spines of normal marmosets developed, and molecular mechanisms of "overshoot-type" of spine development, which human being also shows. Here, we will present our recent effort to explore these questions, and future experiments will be discussed.
authors.affiliation: Laboratory for Ultrastructural Research, National Institute of Neuroscience, National Institute of Neurology and Psychiatry (NCNP), 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan; Ichinohe Neural System Group, Lab for Molecular Analysis of Higher Cognitive Function, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan. Electronic address: nichino@ncnp.go.jp.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Ichinohe
mesh_terms: D000367:Age Factors; D000818:Animals; D002144:Callithrix / Q000033:anatomy & histology*; D049229:Dendritic Spines / Q000502:physiology* / Q000648:ultrastructure; D017397:Prefrontal Cortex / Q000648:ultrastructure; D013569:Synapses / Q000502:physiology
keywords: Overshoot-type development of spines; Pathophysiology; Primate; Pruning; Psychiatry model; Synaptogenesis