title: Prognosis and biology in esthesioneuroblastoma: the emerging role of Hyams grading system.
abstract: Esthesioneuroblastoma is a sinonasal tumor with distinct clinicopathologic features, multiple facets, and a spectrum of behavior. Characterization of this disease is challenging, and clinically, several staging systems have been used with no consensus on a single scheme. Recently, the Hyams histological grading system has emerged as a promising prognostication tool that offers an added value to stage. This review addresses prognosis and biology in esthesioneuroblastoma. More specifically, we sought to present a critical appraisal on the value of each of these stratification systems, stage vs. grade, in identifying risk groups and guiding management.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard (Unit 123), Houston, TX, 77030, USA, resaade@mdanderson.org.
authors.forename: Rami E
authors.initials: RE
authors.lastname: Saade
authors.forename: Ehab Y
authors.initials: EY
authors.lastname: Hanna
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
mesh_terms: D018304:Esthesioneuroblastoma, Olfactory / Q000145:classification / Q000473:pathology*; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods*; D009669:Nose Neoplasms / Q000145:classification / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies