title: Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials.
abstract: BACKGROUND
  Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo.
  
  
  METHODS
  Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo".
  
  
  RESULTS
  Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable.
  
  
  CONCLUSIONS
  The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University , Shenyang , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Bihuan
authors.initials: B
authors.lastname: Xiao
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Gao
mesh_terms: D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012880:Skin Pigmentation; D014820:Vitiligo / Q000628:therapy*
keywords: 308-nm excimer laser; randomized controlled trials; systemic review; vitiligo