title: Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.
abstract: We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. JAR cells were co-cultured with NB and nHAPs for 48 h, and ultrastructural changes were more readily induced by NB than nHAPs. Autophagy in the plasma of JAR cells were observed in the NB group. The rate of apoptosis induced by NB was higher than that for nHAPs. The expression of Bax and FasR proteins in the NB group was stronger than that for the nHAP group. NB probably resulted in autophagic formation. Apoptosis was possibly activated via FasL binding to the FasR signaling pathway.
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Medical College Road, Yuzhong District, Chongqing 400016, People's Republic of China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Medical College Road, Yuzhong District, Chongqing 400016, People's Republic of China.
authors.forename: Jinmei
authors.initials: J
authors.lastname: Yang
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Medical College Road, Yuzhong District, Chongqing 400016, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shu
authors.affiliation: The First People's Hospital of Jiulongpo District, Chongqing, People's Republic of China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Fu
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Medical College Road, Yuzhong District, Chongqing 400016, People's Republic of China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Electron Microscopy Group, Department of Life Science, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Xu
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Medical College Road, Yuzhong District, Chongqing 400016, People's Republic of China.
authors.forename: Dechun
authors.initials: D
authors.lastname: Zhang
keywords: Apoptosis; Autophagy; Cytotoxicity; Human choriocarcinoma (JAR) cells; Nanobacteria (NB); Nanohydroxyapatites (nHAPs)