title: [A case of platinum-resistant, recurrent ovarian clear cell adenocarcinoma successfully treated with irinotecan (CPT-11) and paclitaxel (PTX) chemotherapy].
abstract: A 40-year-old woman presented to a local clinic with abdominal distension. She was referred to our hospital for suspected ovarian cancer. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an ovarian tumor with mural nodules, ascites, pleural effusion, and peritoneal dissemination. Laparotomy revealed a 20-cm right ovarian tumor with strong adhesion to the uterus and rectum. Bilateral salpingo-oophorectomy was performed as a primary surgery. The histopathological diagnosis was stage IVovarian clear cell adenocarcinoma, and 6 cycles of postoperative chemotherapy with a combination of TC (paclitaxel [PTX] and carboplatin) and the mTOR inhibitor temsirolimus was administered. During maintenance treatment with temsirolimus, the lesion recurred, and progressive disease was confirmed. Because relapse occurred after 5 months from the last TC treatment, the disease was considered platinum-resistant ovarian cancer, and second-line chemotherapy with 6 cycles of irinotecan (CPT-11 ) and PTX was administered. Partial response was observed after 2 cycles, and the response period was 7 months. We suggest that chemotherapy with CPT-11/PTX could be a treatment option for platinum resistant recurrent ovarian clear cell adenocarcinoma.
authors.affiliation: Dept. of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Konishi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takehara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Okame
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Atsumi
authors.initials: A
authors.lastname: Kojima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shiroyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nogawa
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D000077146:Irinotecan; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D010984:Platinum / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D010984:Platinum; D000077146:Irinotecan; D017239:Paclitaxel; D002166:Camptothecin