title: An update on the use of immunoglobulin for the treatment of immunodeficiency disorders.
abstract: For patients with significant antibody deficiencies, immunoglobulin therapy is the mainstay of treatment as it significantly reduces both the frequency and severity of infections. The formulations and delivery methods of immunoglobulin have evolved over time, and continued improvements have allowed for increased access to this effective medication. This review is an update on the current status of immunoglobulin therapy in immunodeficiency disorders, and discusses the mechanisms, forms and dosing, and indications for immunoglobulin replacement.
authors.affiliation: Division of Allergy & Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Albin
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cunningham-Rundles
mesh_terms: D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: antibody deficiency; immunoglobulin replacement; intravenous immunoglobulin; mechanisms of immunoglobulin; primary immunodeficiency; subcutaneous immunoglobulin