title: A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes.
abstract: An easily available BINOL-Ti(O(i)Pr)4 catalyst system is found to activate the reaction of Zn powder with EtI for the asymmetric alkyne addition to aldehydes at room temperature. It allows the synthesis of a number of synthetically useful chiral propargylic alcohols with both high yields and high enantioselectivity (up to >96% ee).
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China. xqyu@scu.edu.cn.
authors.forename: Shan-yong
authors.initials: SY
authors.lastname: Chen
authors.forename: Winnie
authors.initials: W
authors.lastname: Liu
authors.forename: Xuedan
authors.initials: X
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Ying
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Yu
authors.forename: Lin
authors.initials: L
authors.lastname: Pu