title: Microengineered vascular systems for drug development.
abstract: Recent advances in microfabrication technologies and advanced biomaterials have allowed for the development of in vitro platforms that recapitulate more physiologically relevant cellular components and function. Microengineered vascular systems are of particular importance for the efficient assessment of drug candidates to physiological barriers lining microvessels. This review highlights advances in the development of microengineered vascular structures with an emphasis on the potential impact on drug delivery studies. Specifically, this article examines the development of models for the study of drug delivery to the central nervous system and cardiovascular system. We also discuss current challenges and future prospects of the development of microengineered vascular systems.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA.
authors.forename: Candice M
authors.initials: CM
authors.lastname: Hovell
authors.affiliation: George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA.
authors.forename: Yoshitaka J
authors.initials: YJ
authors.lastname: Sei
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA ytkim@gatech.edu.
authors.forename: YongTae
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis / Q000706:statistics & numerical data; D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D036103:Nanotechnology; D023822:Tissue Engineering / Q000379:methods*
keywords: fabrication; lab on a chip; microfluidics; microtechnology; nanobiotech; nanotechnology