title: Down syndrome preleukemia and leukemia.
abstract: Children with Down syndrome (DS) and acute leukemias acute have unique biological, cytogenetic, and intrinsic factors that affect their treatment and outcome. Myeloid leukemia of Down syndrome (ML-DS) is associated with high event-free survival (EFS) rates and frequently preceded by a preleukemia condition, the transient abnormal hematopoiesis (TAM) present at birth. For acute lymphoblastic leukemia (ALL), their EFS and overall survival are poorer than non-DS ALL, it is important to enroll them on therapeutic trials, including relapse trials; investigate new agents that could potentially improve their leukemia-free survival; and strive to maximize the supportive care these patients need.
authors.affiliation: Center for Cancer & Blood Disorders, Children's Hospital Colorado, 13123 East 16th Avenue, B115, Aurora, CO 80045, USA.
authors.forename: Kelly W
authors.initials: KW
authors.lastname: Maloney
authors.affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201, USA. Electronic address: jtaub@med.wayne.edu.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Taub
authors.affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201, USA.
authors.forename: Yaddanapudi
authors.initials: Y
authors.lastname: Ravindranath
authors.affiliation: Department of Paediatrics and Molecular Haematology Unit, University of Oxford and Oxford University Hospitals NHS Trust, Oxford, OX3 9DS, UK.
authors.forename: Irene
authors.initials: I
authors.lastname: Roberts
authors.affiliation: MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, Oxford University Hospitals NHS Trust, University of Oxford, Oxford OX3 9DS, UK.
authors.forename: Paresh
authors.initials: P
authors.lastname: Vyas
mesh_terms: D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000235:genetics / Q000628:therapy; D009154:Mutation; D011289:Preleukemia / Q000150:complications* / Q000235:genetics / Q000628:therapy
keywords: B-ALL; Down syndrome; GATA1; Leukemia; Myeloid leukemia of Down syndrome; Preleukemia; Transient abnormal hematopoiesis/transient myeloproliferative disorder