title: Aplastic Anemia & MDS International Foundation (AA&MDSIF): Bone Marrow Failure Disease Scientific Symposium 2014.
abstract: Bone marrow failure syndromes (BMFS) are characterized by a failure of the hematopoietic stem cells to produce adequate blood cells, resulting in either cytopenia (defect in one or more blood cell lineages) or pancytopenia (defect in all blood cell lineages). BMFS can be inherited or acquired. The pathogenesis of these diseases is very heterogeneous. Research efforts have been made all over the world to improve the basic knowledge of these diseases. The Aplastic Anemia and MDS International Foundation (AA&MDSIF) is an independent nonprofit organization whose mission is to help patients and family members cope with BMFS. Here, we summarize novel scientific discoveries in several BMFS that were presented at the 4th International Bone Marrow Failure Disease Scientific Symposium 2014 that AA&MDSIF sponsored on March 27-28, 2014, in Rockville, MD.
authors.affiliation: Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue R4-053, Cleveland, OH 44195, USA. Electronic address: visconv@ccf.org.
authors.forename: Valeria
authors.initials: V
authors.lastname: Visconte
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: R Coleman
authors.initials: RC
authors.lastname: Lindsley
authors.affiliation: Aplastic Anemia & MDS International Foundation, 100 Park Avenue, Ste. 108, Rockville, MD 20850, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Berlyne
mesh_terms: D000741:Anemia, Aplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D001855:Bone Marrow Diseases; D000080983:Bone Marrow Failure Disorders; D003226:Congresses as Topic; D006457:Hemoglobinuria, Paroxysmal / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy
keywords: Aplastic anemia; Genetics; Genomics; Immunobiology; Myelodysplastic syndromes; Paroxysmal nocturnal hemoglobinuria; Transplant and non-transplant therapies