title: Developments in Tau PET Imaging.
abstract: ABSTRACT The presence of neurofibrillary tangles in the brain is a hallmark feature of several neurodegenerative diseases termed "tauopathies," including Alzheimer's disease (AD) and the tau molecular subgroup of frontotemporal lobar degeneration (FTLD-tau). Recently, several positron emission tomography (PET) radiopharmaceuticals targeting abnormal conformations of the tau protein have been developed. To date, six novel tau imaging agents-[18F]THK523, [18F]THK5105, [18F]THK5117, [18F]T807, [18F]T808, and [11C]PBB3-have been described and are considered promising as potential tau radioligands. Tau imaging agents offer the opportunity of in vivo topographical mapping and quantification of tau aggregates in parallel with clinical and cognitive assessments. As such, tau imaging is considered of key importance for progress toward earlier and more accurate diagnosis of tauopathies as well as for the monitoring of therapeutic interventions and drug development. Here, we shed light on the most important developments in tau radiopharmaceuticals, highlighting challenges, possibilities and future directions.
authors.affiliation: 1Translational Neuroimaging Laboratory.
authors.forename: Eduardo Rigon
authors.initials: ER
authors.lastname: Zimmer
authors.affiliation: 1Translational Neuroimaging Laboratory.
authors.forename: Antoine
authors.initials: A
authors.lastname: Leuzy
authors.affiliation: 2Alzheimer's Disease Research Unit,McGill Centre for Studies in Aging,Douglas Mental Health University Institute,Montreal,Quebec,Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: 1Translational Neuroimaging Laboratory.
authors.forename: Pedro
authors.initials: P
authors.lastname: Rosa-Neto
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods / Q000639:trends*; D019275:Radiopharmaceuticals / Q000378:metabolism; D024801:Tauopathies / Q000000981:diagnostic imaging* / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D016875:tau Proteins