title: Hydrocellular foam dressings promote wound healing associated with decrease in inflammation in rat periwound skin and granulation tissue, compared with hydrocolloid dressings.
abstract: The effects of modern dressings on inflammation, which represent the earliest phase of wound healing, are poorly understood. We investigated the effects of modern hydrocellular foam dressings (HCFs) on wound healing and on the gene expression levels of the inflammatory markers--interleukin (IL)-1β, IL-6, and IL-10--in rat periwound skin and granulation tissue by quantitative reverse transcription-polymerase chain reaction. HCF absorbed significantly higher volume of water than hydrocolloid dressing (HCD) and increased the contraction of wounds. Polymorphonuclear neutrophils were massively infiltrated to the wound edge and boarded between granulation and dermis in the HCD group. IL-1β, IL-6, and IL-10 mRNA levels were significantly decreased in the periwound skin around the wounds and granulation tissue covered with HCF. These findings suggest that HCF may promote wound healing along with decrease in inflammation by reducing gene expression levels of IL-1β, IL-6, and IL-10.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.forename: Gojiro
authors.initials: G
authors.lastname: Nakagami
authors.forename: Sawako
authors.initials: S
authors.lastname: Yoshino
authors.forename: Mari
authors.initials: M
authors.lastname: Shimura
authors.forename: Aya
authors.initials: A
authors.lastname: Kitamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Nishijima
authors.forename: Takeo
authors.initials: T
authors.lastname: Minematsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sanada
mesh_terms: D065966:Absorption, Physicochemical / Q000187:drug effects; D000818:Animals; D047070:Bandages, Hydrocolloid; D015415:Biomarkers / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D007249:Inflammation / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D007378:Interleukins / Q000235:genetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D014867:Water / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D007378:Interleukins; D014867:Water
keywords: granulation tissue; hydrocellular foam dressing; inflammation; interleukin; wound healing