title: MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis.
abstract: MicroRNAs (miRNAs) are directly involved in the progression in various cancers. To date, no systematic researches have been performed on the expression pattern of miRNA during progression from low grade gliomas to anaplastic gliomas or secondary glioblastomas and those prognostic miRNAs in anaplastic gliomas and secondary glioblastomas. In the present study, high-throughput microarrays were used to measure miRNA expression levels in 116 samples in the different progression stages of glioma. We found that miRNA expression pattern totally altered when low grade gliomas progressed to anaplastic gliomas or secondary glioblastomas. However, anaplastic gliomas and secondary glioblastomas have similar expression pattern in miRNA level. Furthermore, we developed a five-miRNA signature (two protective miRNAs-miR-767-5p, miR-105; three risky miRNAs: miR-584, miR-296-5p and miR-196a) that could identify patients with a high risk of unfavorable outcome in anaplastic gliomas regardless of histology type. It should be highlighted that the five-miRNA signature can also identify patients who had a high risk of unfavorable outcome in secondary and TCGA Proneural glioblastomas, but not Neural, Classical and Mesenchymal glioblastomas. Taken together, our results demonstrate that miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Yang
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Chuanbao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Zhaoshi
authors.initials: Z
authors.lastname: Bao
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Beijing Institute for Brain Disorders Brain Tumor Center, Beijing, PR China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*; D011379:Prognosis
chemical_list: D035683:MicroRNAs