title: Epigenetics of gastric cancer.
abstract: Epigenetic changes frequently occur in human gastric cancer. Gene promoter region hypermethylation, genomic global hypomethylation, histone modifications, and alterations of noncoding RNAs are major epigenetic changes in gastric cancer. As a key risk factor of gastric cancer, H. pylori infection is an independent predictive indicator of gene methylation. A growing number of epigenetic studies in gastric cancer have provided lots of potential diagnostic and prognostic markers and therapeutic targets.
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China, mzguo1@gmail.com.
authors.forename: Mingzhou
authors.initials: M
authors.lastname: Guo
authors.forename: Wenji
authors.initials: W
authors.lastname: Yan
mesh_terms: D000818:Animals; D019175:DNA Methylation; D057890:Epigenomics / Q000379:methods*; D006657:Histones / Q000235:genetics; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D006657:Histones; D022661:RNA, Untranslated