title: Gastroenteropancreatic neuroendocrine tumour arising in Meckel's diverticulum coexisting with colon adenocarcinoma.
abstract: Although colon cancer is the third most common cause of cancer-related death worldwide, the prevalence of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) remains rare. To date, very few cases of GEP-NETs within Meckel's diverticulum and synchronous colorectal cancer have been reported. Although the coexistence of these two tumour types is uncommon, it is important to be aware of their disease patterns. We present a rare case of a patient with an intestinal GEP-NET arising in Meckel's diverticulum coexisting with metastatic colon adenocarcinoma, and we discuss the clinical manifestations and the diagnostic procedures and treatment modalities used. This case report underlines the importance of being aware of this particular coexistence, as well as the unlikely metastatic spread of GEP-NETs and the importance of a multidisciplinary approach to cancer treatment. Finally, individualizing the treatment according to the stages of the primaries will result in durable cancer control, particularly in synchronous double malignancy.
authors.affiliation: Department of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia. darko.katalinic@kbc-zagreb.hr.
authors.forename: Darko
authors.initials: D
authors.lastname: Katalinic
authors.forename: Fedor
authors.initials: F
authors.lastname: Santek
authors.forename: Antonio
authors.initials: A
authors.lastname: Juretic
authors.forename: Dinko
authors.initials: D
authors.lastname: Skegro
authors.forename: Stjepko
authors.initials: S
authors.lastname: Plestina
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007414:Intestinal Neoplasms / Q000556:secondary* / Q000601:surgery; D008297:Male; D008467:Meckel Diverticulum / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000556:secondary* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery; D011379:Prognosis; D013274:Stomach Neoplasms / Q000556:secondary* / Q000601:surgery