title: Applications of dendrimers for brain delivery and cancer therapy.
abstract: Dendrimers are emerging as potential nonviral vectors for the efficient delivery of drugs and nucleic acids to the brain and cancer cells. These polymers are highly branched, 3D macromolecules with modifiable surface functionalities and available internal cavities that make them attractive as delivery systems for drug and gene delivery applications. This article highlights the recent therapeutic advances resulting from the use of dendrimers for brain targeting and cancer treatment.
authors.affiliation: Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.
authors.forename: Sukrut
authors.initials: S
authors.lastname: Somani
authors.forename: Christine
authors.initials: C
authors.lastname: Dufès
mesh_terms: D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000628:therapy*; D050091:Dendrimers / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans
chemical_list: D050091:Dendrimers
keywords: brain delivery; cancer therapy; dendrimer; gene therapy; tumor targeting