title: Combined effect of established BMI loci on obesity-related traits in an Algerian population sample.
abstract: BACKGROUND
  Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study.
  
  
  RESULTS
  We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004).
  
  
  CONCLUSIONS
  Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.
authors.forename: Manel Nassima
authors.initials: MN
authors.lastname: Badsi
authors.forename: Sounnia
authors.initials: S
authors.lastname: Mediene-Benchekor
authors.forename: Hadjira
authors.initials: H
authors.lastname: Ouhaibi-Djellouli
authors.forename: Sarah Aicha
authors.initials: SA
authors.lastname: Lardjam-Hetraf
authors.forename: Houssam
authors.initials: H
authors.lastname: Boulenouar
authors.forename: Djabaria Naïma
authors.initials: DN
authors.lastname: Meroufel
authors.forename: Xavier
authors.initials: X
authors.lastname: Hermant
authors.forename: Imane
authors.initials: I
authors.lastname: Hamani-Medjaoui
authors.forename: Nadhira
authors.initials: N
authors.lastname: Saidi-Mehtar
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Leila
authors.initials: L
authors.lastname: Houti
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
authors.forename: Louisa
authors.initials: L
authors.lastname: Goumidi
mesh_terms: D000462:Algeria; D015992:Body Mass Index; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide