title: Intraoral features and considerations in face transplantation.
abstract: Face transplantation (FT) is a unique and novel addition to the field of reconstructive surgery, which offers new hope to facially disfigured individuals. This review provides an overview of FT, including clinical indications, immunological principles, and functional outcomes, as well as an in-depth characterization of the intraoral hard and soft tissue findings in the six patients transplanted to date at Brigham and Women's Hospital in Boston, MA, USA. Six FT recipients underwent comprehensive clinical and radiographic evaluation to assess their intraoral status, function, and overall health. The extra- and intraoral soft tissue was assessed via quantitative sensory testing. The vitality of the transplanted dental hard tissue was evaluated with clinically available testing methods. Native teeth and prostheses were also assessed. Sensation of transplanted oral mucosa varied based on time elapsed from FT, ranging from minimal at 3 months post-FT, to nearly complete recovery by approximately 24 months. There was mixed success with the integration of donor teeth (Patients 1, 4 and 6), including associated occlusal discrepancies. Mucosal complications included constriction at the donor/recipient interface (Patients 2 and 5) and solitary episodes of mucosal rejection presenting as lichenoid inflammation (Patients 2 and 4). Face transplantation represents a pivotal moment in the history of reconstructive surgery and transplant medicine, providing new optimism to patients with gross facial deformities. This report highlights the successes of FT, but also the challenges of transplanting hard and soft tissues to restore complex stomatognathic function. Further attention directed toward comprehensive oral rehabilitation in FT will contribute to improved outcomes, with the ultimate goal of restoring and optimizing patient quality of life.
authors.affiliation: Department of Oral Medicine and Dentistry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: A
authors.identifier: http://orcid.org/0000-0003-2528-1390
authors.initials: A
authors.lastname: Wall
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Bueno
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Pomahac
authors.affiliation: Department of Oral Medicine and Dentistry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: N
authors.initials: N
authors.lastname: Treister
mesh_terms: D003766:Dental Occlusion; D054445:Facial Transplantation / Q000941:ethics; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D009061:Mouth Mucosa / Q000503:physiopathology / Q000637:transplantation*; D018579:Patient Selection; D012677:Sensation; D014070:Tooth / Q000637:transplantation*
keywords: face transplantation; graft-versus-host disease; lichenoid inflammation; transplant medicine