title: Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral.
abstract: As a special aphasia, the occurrence of crossed aphasia in dextral (CAD) is unusual. This study aims to improve the language ability by applying 1 Hz repetitive transcranial magnetic stimulation (rTMS). We studied multiple modality imaging of structural connectivity (diffusion tensor imaging), functional connectivity (resting fMRI), PET, and neurolinguistic analysis on a patient with CAD. Furthermore, we applied rTMS of 1 Hz for 40 times and observed the language function improvement. The results indicated that a significantly reduced structural and function connectivity was found in DTI and fMRI data compared with the control. The PET imaging showed hypo-metabolism in right hemisphere and left cerebellum. In conclusion, one of the mechanisms of CAD is that right hemisphere is the language dominance. Stimulating left Wernicke area could improve auditory comprehension, stimulating left Broca's area could enhance expression, and the results outlasted 6 months by 1 Hz rTMS balancing the excitability inter-hemisphere in CAD.
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center Beijing 100068, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Lu
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences Beijing 100101, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Center of Brainnetome, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing 100190, China.
authors.forename: Hewei
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Center of Brainnetome, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing 100190, China.
authors.forename: Dongjie
authors.initials: D
authors.lastname: Wei
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center Beijing 100068, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Center of Brainnetome, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing 100190, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center Beijing 100068, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center Beijing 100068, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
keywords: Crossed aphasia in dextral; diffusion tensor imaging; functional magnetic resonance imaging; positron emission tomography; repetitive transcranial magnetic stimulation