title: Shaping the intestinal brush border.
abstract: Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Crawley
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Department of Cell Biology, and Department of Pathology, Yale University, New Haven, CT 06520 Department of Molecular, Cellular and Developmental Biology, Department of Cell Biology, and Department of Pathology, Yale University, New Haven, CT 06520 Department of Molecular, Cellular and Developmental Biology, Department of Cell Biology, and Department of Pathology, Yale University, New Haven, CT 06520.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Mooseker
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 matthew.tyska@vanderbilt.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Tyska
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D020895:Enterocytes / Q000166:cytology*; D006801:Humans; D007422:Intestines / Q000166:cytology*; D051379:Mice; D008871:Microvilli / Q000502:physiology* / Q000648:ultrastructure; D018995:Myosin Heavy Chains / Q000502:physiology; D024461:Myosin Type I / Q000502:physiology; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D018995:Myosin Heavy Chains; D024461:Myosin Type I; D000099149:Ezrin; C062291:MYO1A protein, human; C089785:myosin VI