title: Application of ionic liquid-TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples.
abstract: An ionic liquid-TiO2 nanoparticle modified carbon paste electrode (IL-TiO2/CPE) was used as a fast and sensitive tool for the investigation of the electrochemical oxidation of benserazide using voltammetry. This modified electrode has been fabricated using hydrophilic ionic liquid (n-hexyl-3-methylimidazolium hexafluoro phosphate) as a binder. The modified electrode offers a considerable improvement in voltammetric sensitivity toward benserazide, compared to the bare electrode. Using differential pulse voltammetry (DPV), the electrocatalytic oxidation peak current of benserazide shows a linear calibration curve in the range of 1.0-600 μmol L(-1) benserazide. The limit of detection was equal to 0.4 μmol L(-1). The relative standard deviation (RSD%) for eight successive assays of 10 μmol L(-1) benserazide was 1.1%. Finally, the proposed method was successfully applied to the determination of benserazide in real samples such as blood serum and urine.
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: ensafi@cc.iut.ac.ir.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Ensafi
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Bahrami
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Rezaei
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Karimi-Maleh
mesh_terms: D001545:Benserazide / Q000032:analysis* / Q000097:blood / Q000652:urine; D002244:Carbon / Q000737:chemistry; D015259:Dopamine Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D052578:Ionic Liquids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D015259:Dopamine Agents; D052578:Ionic Liquids; C009495:titanium dioxide; D002244:Carbon; D001545:Benserazide; D014025:Titanium