title: Sarcomas.
abstract: Malignant bone tumors (osteosarcoma, Ewing sarcoma) and soft-tissue sarcomas (rhabdomyosarcoma, nonrhabdomyosarcoma) account for approximately 14% of childhood malignancies. Successful treatment of patients with sarcoma depends on a multidisciplinary approach to therapy, including oncology, surgery, radiation oncology, radiology, pathology, and physiatry. By combining systemic treatment with chemotherapy and primary tumor control using surgery and/or radiation, survival rates for localized disease range from 70% to 75%. However, children with metastatic or recurrent disease continue to have dismal outcomes. A better understanding of the biology underlying both bone and soft-tissue sarcomas is required to further improve outcomes for children with these tumors.
authors.affiliation: Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Pediatrics, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS 54, Los Angeles, CA 90027, USA.
authors.forename: Josephine H
authors.initials: JH
authors.lastname: HaDuong
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Medical Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 9063, Dallas, TX 75390, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Martin
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Medical Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 9063, Dallas, TX 75390, USA.
authors.forename: Stephen X
authors.initials: SX
authors.lastname: Skapek
authors.affiliation: Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Pediatrics, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS 54, Los Angeles, CA 90027, USA. Electronic address: lmascarenhas@chla.usc.edu.
authors.forename: Leo
authors.initials: L
authors.lastname: Mascarenhas
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy
keywords: Bone; Ewing’s; Nonrhabdomyosarcoma; Osteosarcoma; Rhabdomyosarcoma; Soft-tissue sarcoma