title: Associations among four polymorphisms (BsmI, FokI, TaqI and ApaI) of vitamin D receptor gene and end-stage renal disease: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association between vitamin D receptor (VDR) BsmI, FokI, TaqI and ApaI gene polymorphisms and the risk of end-stage renal disease (ESRD).
  
  
  METHODS
  All eligible studies were included in our meta-analysis of a search of the PubMed, Cochrane and China National Knowledge Infrastructure (CNKI) databases according to predefined criteria. The fixed-effects or random-effects models were used to calculate the pooled odds ratio (OR) and corresponding 95% confidence interval (CI).
  
  
  RESULTS
  Thirteen studies including 1510 patients and 1812 controls were recruited for the analysis of the association between the VDR BsmI, FokI, TaqI and ApaI gene polymorphisms and the risk of ESRD.VDR BsmI B allele, BB genotype and bb genotype, FokI F allele, FF genotype and ff genotype, TaqI T allele, TT genotype and tt genotype, ApaI A allele, AA genotype and aa genotype were not associated with ESRD susceptibility for overall populations, Asians and Caucasians.
  
  
  CONCLUSIONS
  Results from the current study suggest that VDR BsmI, FokI, TaqI and ApaI gene polymorphisms are not associated with the risk of ESRD in the overall populations, Asians and Caucasians. However, more studies should be performed in the future.
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Lina
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: majiangfei@medmail.com.cn.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Ma
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: C498440:BSN protein, human; D009419:Nerve Tissue Proteins; D018167:Receptors, Calcitriol; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases; C027046:TCGA-specific type II deoxyribonucleases
keywords: BsmI; End-stage renal disease; FokI; Gene polymorphisms; Meta-analysis; TaqI and ApaI; Vitamin D receptor