title: Trends of subtype variation of human immunodeficiency virus type 1 in Zhejiang Province, China.
abstract: The epidemic characteristics of human immunodeficiency virus type 1 (HIV-1) in Zhejiang Province have not been systematically identified. This study presented a dynamic analysis of HIV-1 subtype variation in Zhejiang from 2004 to 2008, based on the surveillance of molecular epidemiology or drug resistance. CRF01_AE was the major strain (43.5 %) spreading across the province, second by B/B' (17.9 %), CRF07_BC (17.1 %), and CRF08_BC (13.7 %). The strains were mainly transmitted by heterosexual contact. Novel recombinant strains and vertical transmission were occasionally reported. Floating population from other provinces accounted for a significant number of HIV-1 cases in Zhejiang. These data may provide us rational intervention strategy for further control of HIV dissemination.
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People's Republic of China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Yao
authors.forename: Ruolei
authors.initials: R
authors.lastname: Xin
authors.forename: Jiezhe
authors.initials: J
authors.lastname: Yang
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xia
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Pan
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Guo
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D018562:Disease Transmission, Infectious; D024882:Drug Resistance, Viral; D062665:Epidemiological Monitoring; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012725:Sexual Behavior; D055815:Young Adult