title: N-isopropylacrylamide-based fine-dispersed thermosensitive ferrogels obtained via in-situ technique.
abstract: Thermosensitive hydrogels with magnetic properties (ferrogels) are very promising for medical application, first of all, for the design of targeted delivery systems with controlled release of drugs and for magnetic hyperthermia and chemotherapy treatment of cancer. These magnetic hydrogels could be obtained using diverse techniques: ex- and in-situ syntheses. The present work is devoted to the study of magnetite (Fe(3)O(4)) formation inside the nanoreactors of (co)polymeric hydrogels. Polymeric templates (hydrogel films and fine-dispersed hydrogels) used for obtaining ferrogels were based on acrylic monomers: thermosensitive N-isopropylacrylamide, and hydrophilic acrylamide. Covalent cross-linking was accomplished using bifunctional monomer N,N'-methylenebisacrylamide. Influence of hydrophilic-lipophilic balance of polymeric templates and concentration of iron cations on the magnetite formation were investigated along with the development of ferrogel preparation technique. Cytotoxicity, physical and chemical properties of obtained magnetic hydrogels have been studied in this work.
authors.affiliation: Ovcharenko Institute of Biocolloid Chemistry, National Academy of Sciences of Ukraine, Vernadskogo Blvd. 42, Kyiv, 03680, Ukraine. Electronic address: korotych.elena@gmail.com.
authors.forename: O
authors.initials: O
authors.lastname: Korotych
authors.affiliation: Ovcharenko Institute of Biocolloid Chemistry, National Academy of Sciences of Ukraine, Vernadskogo Blvd. 42, Kyiv, 03680, Ukraine. Electronic address: yu1sam@yahoo.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Samchenko
authors.affiliation: Ovcharenko Institute of Biocolloid Chemistry, National Academy of Sciences of Ukraine, Vernadskogo Blvd. 42, Kyiv, 03680, Ukraine.
authors.forename: I
authors.initials: I
authors.lastname: Boldeskul
authors.affiliation: Ovcharenko Institute of Biocolloid Chemistry, National Academy of Sciences of Ukraine, Vernadskogo Blvd. 42, Kyiv, 03680, Ukraine.
authors.forename: Z
authors.initials: Z
authors.lastname: Ulberg
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotnogo St. 154, Kyiv, D0368, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Zholobak
authors.affiliation: Sumy State University, Medical Institute, Ministry of Education and Science, Youth and Sport of Ukraine, R. Korsakova Str. 2, Sumy, 40007, Ukraine.
authors.forename: L
authors.initials: L
authors.lastname: Sukhodub
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size
chemical_list: D000178:Acrylamides; D020100:Hydrogels; D058185:Magnetite Nanoparticles; C067295:N-isopropylacrylamide