title: K2CO3-mediated synthesis of functionalised 4-substituted-2-amino-3-cyano-4H-chromenes via Michael-cyclization reactions.
abstract: An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K2CO3 catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.
authors.affiliation: Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. heyanyang89@126.com.
authors.forename: Yanyang
authors.initials: Y
authors.lastname: He
authors.affiliation: Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. airinwalk@sohu.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Pharmaceutical Department of Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610072, China. tongrs@126.com.
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Tong
authors.affiliation: Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. l@lifq.cn.
authors.forename: Fengqiong
authors.initials: F
authors.lastname: Li
authors.affiliation: Pharmaceutical Department of Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610072, China. yuyuraul@126.com.
authors.forename: Jianyou
authors.initials: J
authors.lastname: Shi
authors.affiliation: Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. zhangmei63@126.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002254:Carbonates / Q000737:chemistry*; D003500:Cyclization; D011188:Potassium / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001578:Benzopyrans; D002254:Carbonates; C037593:potassium carbonate; D011188:Potassium