title: Autograft soaking in vancomycin reduces the risk of infection after anterior cruciate ligament reconstruction.
abstract: OBJECTIVE
  To determine whether the bathing of an anterior cruciate ligament (ACL) autograft in vancomycin reduces the rate of infection following an ACL reconstruction.
  
  
  METHODS
  Retrospective analysis of all ACL reconstructions over an 8-year period in two University Hospitals. In the initial 4-year period, all patients were operated on under classical antibiotic intravenous prophylaxis (group 1). Over the last 4-year period, this prophylaxis was supplemented with presoaking of the autograft (group 2). Presoaking was performed with sterile gauze previously saturated with a vancomycin solution (5 mg/ml).
  
  
  RESULTS
  There were 810 and 734 patients in group 1 and 2, respectively. Fifteen cases of knee joint infections were identified in the series (0.97 %). All of these infections occurred in group 1, representing a rate of infection of 1.85 % in comparison with 0 % in group 2 (p < 0.001).
  
  
  CONCLUSIONS
  Autograft presoaking with vancomycin in combination with classical intravenous antibiotic prophylaxis reduced the rate of knee joint infection following an ACLR in comparison with antibiotic prophylaxis alone. This technique could be of relevance in daily clinical practice to prevent infection after ACLR.
  
  
  METHODS
  Case control study, retrospective comparative study, Level III.
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain. dperezprieto@hospitaldelmar.cat.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pérez-Prieto
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Torres-Claramunt
authors.affiliation: ICATME - Hospital Universitari Quirón-Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain.|Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Pablo E
authors.initials: PE
authors.lastname: Gelber
authors.affiliation: Mohamed Dossary Hospital, Al Khobar, Saudi Arabia.
authors.forename: Tamer M A
authors.initials: TMA
authors.lastname: Shehata
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain.|ICATME - Hospital Universitari Quirón-Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pelfort
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain.|ICATME - Hospital Universitari Quirón-Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Monllau
mesh_terms: D016118:Anterior Cruciate Ligament / Q000187:drug effects / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001170:Arthritis, Infectious / Q000209:etiology / Q000517:prevention & control; D001182:Arthroscopy; D064592:Autografts; D050376:Bone-Patellar Tendon-Bone Grafting; D016022:Case-Control Studies; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012306:Risk; D014182:Transplantation, Autologous; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: Anterior cruciate ligament; Antibiotic prophylaxis; Biofilm; Knee infection; Vancomycin