title: Ultrasensitive and selective detection of dopamine using cobalt-phthalocyanine nanopillar-based surface acoustic wave sensor.
abstract: A highly selective and sensitive surface acoustic wave (SAW) sensor of dopamine (DA) was developed by depositing cobalt phthalocyanine (CoPc) nanopillars on gold-coated sensing platform of SAW sensor. The developed biosensor presents a sensitivity of 1.6°/nM, has a low limit of detection (LOD) on the order of 0.1 nM, and imparts more selectivity toward DA, since the detection limit of the interfering ascorbic acid (AA) is as high as 1 mM. To understand the selectivity mechanisms of this sensor toward DA, density functional theory-based chemical calculations were carried out. Calculations suggest two different types of interactions: dative bond with a very strong character for DA-CoPc complexes, and significant ionic character in the case of AA-CoPc ones. The interaction energies, in liquid phase, were estimated to be equal to -81 kJ mol(-1) and -38 kJ mol(-1) for DA-CoPc and AA-CoPc complexes, respectively, therefore accounting for the selective detection of DA over AA using tandem CoPc nanopillar-based SAW sensor device. This work demonstrates a simple and efficient design of SAW sensors employing thin nanostructured CoPc biomolecular recognition layers for DA detection.
authors.affiliation: CNRS-ENS Cachan-Cnam, SATIE, UMR 8029 , 292 rue Saint Martin, 75003 Paris, France.
authors.forename: Najla
authors.initials: N
authors.lastname: Fourati
authors.forename: Mahamadou
authors.initials: M
authors.lastname: Seydou
authors.forename: Chouki
authors.initials: C
authors.lastname: Zerrouki
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
authors.forename: Soumen
authors.initials: S
authors.lastname: Samanta
authors.forename: François
authors.initials: F
authors.lastname: Maurel
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Aswal
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chehimi
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation; D003035:Cobalt / Q000737:chemistry*; D003198:Computer Simulation; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D008956:Models, Chemical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013016:Sound; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D007211:Indoles; D054833:Isoindoles; D003035:Cobalt; C013647:phthalocyanine; D004298:Dopamine
keywords: SAW sensor; ascorbic acid; chemical calculations; cobalt phthalocyanine; dopamine