title: An Overview of Arsenic Metabolism and Toxicity.
abstract: It is likely that at least some of the toxic and carcinogenic effects associated with exposure to inorganic arsenic are, in fact, due to actions of its methylated metabolites. Here, we provide an overview of current models for the biological methylation of arsenicals. This information provides a context for understanding the chemical, biochemical, and genetic approaches to elucidation of the formation and function of metahylated arsenicals which are presented in the following manuscripts.
authors.affiliation: Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7461.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Drobna
authors.affiliation: Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7461 ; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7310.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Styblo
authors.affiliation: Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park North Carolina 27709.
authors.forename: David J
authors.initials: DJ
authors.lastname: Thomas