title: Prognostic analysis of schistosomal rectal cancer.
abstract: BACKGROUND
  Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. However, there have been only few reports of prognosis of patients with schistosomal rectal cancer SRC.
  
  
  OBJECTIVE
  This study aimed to analyze differences in prognosis between SRC and non-schistosomal rectal cancer(NSRC) with current treatments.
  
  
  METHODS
  A retrospective review of 30 patients with schistosomal rectal cancer who underwent laparoscopic total mesorectal excision operation (TME) was performed. For each patient with schistosomal rectal cancer, a control group who underwent laparoscopic TME with non-schistosomal rectal cancer was matched for age, gender and tumor stage, resulting in 60 cases and controls.
  
  
  RESULTS
  Univariate analysis showed pathologic N stage (P=0.006) and pathologic TNM stage (P=0.047) statistically significantly correlated with disease-free survival (DFS). Pathologic N stage (P=0.014), pathologic TNM stage (P=0.002), and with/without schistosomiasis (P=0.026) were statistically significantly correlated with overall survival (OS). Schistosomiasis was the only independent prognostic factor for DFS and OS in multivariate analysis.
  
  
  CONCLUSIONS
  The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer.
authors.affiliation: Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China E-mail : hxwangm@126.com.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Yuan-Chuan
authors.initials: YC
authors.lastname: Zhang
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Yang
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000469:parasitology* / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000469:parasitology* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D012552:Schistosomiasis / Q000150:complications*; D015996:Survival Rate; D047368:Tumor Burden