title: Superior sulcus non small cell lung carcinoma: retrospective analysis of 42 patients.
abstract: OBJECTIVE
  Retrospective, monocentric analysis of localized superior sulcus non-small cell cancer (SS-NSCLC), article management.
  
  
  METHODS
  Between 2000 and 2010, 42 patients have been treated for a SS-NSCLC. Median age was 54.7 years (34.5-86.8). Nineteen tumors (45.2%) were stage IIB, 18 were stage IIIA (42.9%) and 5 were stage IIIB (11.9%). Twenty-two patients were treated by pre-operative radiotherapy or chemoradiotherapy, 20 received exclusive radiotherapy or chemoradiotherapy. Preoperative and exclusive median radiotherapy doses were 46 Gy (40-47 Gy) and 51.8 Gy (40-70 Gy), respectively. All patients treated with chemotherapy received at least platinum. Mean follow up was 44.1 months (0-128 months).
  
  
  RESULTS
  Local, loco-regional and metastatic relapses occurred in 11 (26.2%), 2 (4.8%) and 15 patients (35.7%), respectively. Most common metastatic site was cerebral (7 patients, 46.7%). Median disease-free survival (DFS) was 9.7 months (8.9-10.4). One-, 2- and 5- years DFS rates were 44%, 33% and 26.5%, respectively. No prognostic factor was identified. Median overall survival (OS) was 22.6 months (10.4-34.8). One-, 2- and 5- years OS rates were 61.9%, 44.9% and 30.1%, respectively. Univariate prognostic factors for OS were WHO (p = 0.027) and tumoral response (p = 0.05). In multivariate analysis, independent favorable prognostic factors were WHO 0-1 (p = 0.017; OR = 0.316 [CI95% 0.123-0.81) and complete response to treatment (p = 0.035; OR = 0.312 [IC95% 0.106-0.919]).
  
  
  CONCLUSIONS
  This study highlighted that a good performans status and complete response to treatment are independent factors of OS, whatever the delivered treatment. Brain was the most common metastatic relapse site.
authors.affiliation: Radiotherapy Department, Centre Paul Strauss, 3, rue de la Porte de l'Hôpital, BP 42, 67065, Strasbourg cedex, France. ptruntzer@strasbourg.unicancer.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Truntzer
authors.affiliation: Radiotherapy Department, Centre Paul Strauss, 3, rue de la Porte de l'Hôpital, BP 42, 67065, Strasbourg cedex, France. dantoni@strasbourg.unicancer.fr.|Radiobiology Laboratory EA 3430, Federation of Translational Medicine in Strasbourg (FMTS), Strasbourg University, Strasbourg, France. dantoni@strasbourg.unicancer.fr.
authors.forename: Delphine N
authors.initials: DN
authors.lastname: Antoni
authors.affiliation: Thoracic surgery department, Nouvel Hôpital civil, 1, place de l'Hôpital, 67091, Strasbourg cedex, France. nicola.santelmo@chru-strasbourg.fr.
authors.forename: Nicola
authors.initials: N
authors.lastname: Santelmo
authors.affiliation: Radiotherapy Department, Centre Paul Strauss, 3, rue de la Porte de l'Hôpital, BP 42, 67065, Strasbourg cedex, France. cschumacher@strasbourg.unicancer.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Schumacher
authors.affiliation: Thoracic surgery department, Nouvel Hôpital civil, 1, place de l'Hôpital, 67091, Strasbourg cedex, France. pierre-emmanuel.falcoz@chru-strasbourg.fr.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Falcoz
authors.affiliation: Pneumology department, Nouvel Hôpital Civil, 1, place de l'Hôpital, 67091, Strasbourg cedex, France. elisabeth.quoix@chru-strasbourg.fr.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Quoix
authors.affiliation: Orthopaedic Department, Hôpital Civil, 1, place de l'Hôpital, 67091, Strasbourg cedex, France. Jean-pierre.steib@chru-strasbourg.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Steib
authors.affiliation: Thoracic surgery department, Nouvel Hôpital civil, 1, place de l'Hôpital, 67091, Strasbourg cedex, France. Gilbert.massard@chru-strasbourg.fr.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Massard
authors.affiliation: Radiotherapy Department, Centre Paul Strauss, 3, rue de la Porte de l'Hôpital, BP 42, 67065, Strasbourg cedex, France. gnoel@strasbourg.unicancer.fr.|Radiobiology Laboratory EA 3430, Federation of Translational Medicine in Strasbourg (FMTS), Strasbourg University, Strasbourg, France. gnoel@strasbourg.unicancer.fr.
authors.forename: Georges
authors.initials: G
authors.lastname: Noël
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D012189:Retrospective Studies; D016896:Treatment Outcome