title: Prevalence of congenital heart defects associated with Down syndrome in Korea.
abstract: Congenital heart defect (CHD) is common in infants with Down syndrome (DS), which is the principle cause of mortality. However, there is no data available for the frequency and types of CHD in infants with DS in Korea. We investigated the frequency of CHD in infants with DS in Korea. After the survey on birth defects was conducted throughout the country, the prevalence of CHD in DS in 2005-2006 was calculated. This study was conducted based on the medical insurance claims database of the National Health Insurance Corporation. The number of total births in Korea was 888,263 in 2005-2006; of them, 25,975 cases of birth defects were identified. The prevalence of DS was 4.4 per 10,000 total births, accounting for 1.5% of all birth defects. Of the 394 infants with DS, 224 (56.9%) had a CHD. Atrial septal defect was the most common defect accounting for 30.5% of DS followed by ventricular septal defect (19.3%), patent duct arteriosus (17.5%), and atrioventricular septal defect (9.4%). Our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in infants with DS in Korea.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Min-A
authors.identifier: 0000-0002-6199-2010
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: You Sun
authors.identifier: 0000-0003-0336-4478
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Health Policy Research Division, Korea Institute for Health and Social Affairs, Seoul, Korea.
authors.forename: Nan Hee
authors.identifier: 0000-0002-2026-3321
authors.initials: NH
authors.lastname: Yee
authors.affiliation: Health Policy Research Division, Korea Institute for Health and Social Affairs, Seoul, Korea.
authors.forename: Jeong Soo
authors.identifier: 0000-0002-7827-1930
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Jung Yun
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung
authors.identifier: 0000-0001-6657-3889
authors.initials: K
authors.lastname: Seo
mesh_terms: D000328:Adult; D044466:Asian People; D001724:Birth Weight; D002869:Chromosome Aberrations; D016208:Databases, Factual; D004314:Down Syndrome / Q000150:complications*; D004374:Ductus Arteriosus, Patent / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000453:epidemiology* / Q000209:etiology; D006343:Heart Septal Defects / Q000453:epidemiology; D006344:Heart Septal Defects, Atrial / Q000453:epidemiology; D006345:Heart Septal Defects, Ventricular / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology
keywords: Down Syndrome; Heart Defects, Congenital; Prevalence, Korea