title: Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria.
abstract: Four eudesmanolide sesquiterpene lactones (1-4) were isolated from the aerial parts of Vernonia blumeoides used in Nigerian ethnomedicine for the treatment of diarrhea and malaria. Compound 1 demonstrated limited but interesting antibacterial activity against Bacillus, Staphylococcus and Streptococcus species. The crystal structure of 1 allowed the absolute configuration of the stereocentres in the molecule to be assigned.
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria. Electronic address: Aliyubabando@gmail.com.
authors.forename: Abubakar Babando
authors.initials: AB
authors.lastname: Aliyu
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa. Electronic address: Moodleyb3@ukzn.ac.za.
authors.forename: Brenda
authors.initials: B
authors.lastname: Moodley
authors.affiliation: School of Life Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa. Electronic address: Cheniah@ukzn.ac.za.
authors.forename: Hafizah
authors.initials: H
authors.lastname: Chenia
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa. Electronic address: Koorbanally@ukzn.ac.za.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Koorbanally
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D018360:Crystallography, X-Ray; D003967:Diarrhea / Q000188:drug therapy; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008288:Malaria / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009549:Nigeria; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035741:Vernonia / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D012717:Sesquiterpenes; C000598001:blumeoidolide A; C476916:eudesmanolide
keywords: Antibacterial activity; Eudesmanes; Sesquiterpene lactones; Vernonia blumeoides