title: Mutation in PIGA results in a CD52-negative escape variant in a Sézary syndrome patient during alemtuzumab treatment.
authors.affiliation: Department of Hematology, University Medical Center Leiden, Leiden, The Netherlands. Electronic address: c.j.m.halkes@lumc.nl.
authors.forename: Constantijn J M
authors.initials: CJM
authors.lastname: Halkes
authors.affiliation: Department of Dermatology, University Medical Center Leiden, Leiden, The Netherlands.
authors.forename: Willem H
authors.initials: WH
authors.lastname: Zoutman
authors.affiliation: Department of Dermatology, University Medical Center Leiden, Leiden, The Netherlands.
authors.forename: Leslie
authors.initials: L
authors.lastname: van der Fits
authors.affiliation: Department of Hematology, University Medical Center Leiden, Leiden, The Netherlands.
authors.forename: Inge
authors.initials: I
authors.lastname: Jedema
authors.affiliation: Department of Dermatology, University Medical Center Leiden, Leiden, The Netherlands.
authors.forename: Maarten H
authors.initials: MH
authors.lastname: Vermeer
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000378:metabolism; D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D015703:Antigens, CD / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000235:genetics*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000074301:CD52 Antigen; D006023:Glycoproteins / Q000235:genetics*; D017261:Glycosylphosphatidylinositols / Q000737:chemistry; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation; D011379:Prognosis; D012008:Recurrence; D017422:Sequence Analysis, DNA; D012751:Sezary Syndrome / Q000188:drug therapy* / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; C080086:phosphatidylinositol glycan-class A protein; D000074323:Alemtuzumab; D000410:Alanine Transaminase