title: DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.
abstract: microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 (http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available.
authors.affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vlachos
authors.affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Paraskevopoulou
authors.affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Karagkouni
authors.affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Georgakilas
authors.affiliation: 'Athena' Research and Innovation Center, 11524 Athens, Greece.
authors.forename: Thanasis
authors.initials: T
authors.lastname: Vergoulis
authors.affiliation: 'Athena' Research and Innovation Center, 11524 Athens, Greece School of Electrical and Computer Engineering, NTUA, 15773 Zografou, Greece.
authors.forename: Ilias
authors.initials: I
authors.lastname: Kanellos
authors.affiliation: Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
authors.forename: Ioannis-Laertis
authors.initials: IL
authors.lastname: Anastasopoulos
authors.affiliation: Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Maniou
authors.affiliation: Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Karathanou
authors.affiliation: Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
authors.forename: Despina
authors.initials: D
authors.lastname: Kalfakakou
authors.affiliation: Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Fevgas
authors.affiliation: 'Athena' Research and Innovation Center, 11524 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
authors.forename: Theodore
authors.initials: T
authors.lastname: Dalamagas
authors.affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
authors.forename: Artemis G
authors.initials: AG
authors.lastname: Hatzigeorgiou
mesh_terms: D000043:Abstracting and Indexing; D001665:Binding Sites; D057225:Data Mining; D030561:Databases, Nucleic Acid; D020407:Internet; D035683:MicroRNAs / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger