title: Diastolic dysfunction and contrast-induced nephropathy in patients undergoing coronary angiography.
abstract: OBJECTIVE
  It has been demonstrated that decreased left ventricular ejection fraction (LVEF) is associated with an increased risk of contrast-induced nephropathy (CIN). In this study, we aimed to assess whether there is a relationship between left ventricular (LV) diastolic dysfunction and renal function decline after coronary angiography (CAG).
  
  
  METHODS
  The study consisted of two groups: group I, patients with normal diastolic function; group II, patients with cardiac symptoms and abnormal diastolic function. Serum creatinine (Crea) and glomerular filtration rates (GFR) were measured before and after 48 h of CAG.
  
  
  RESULTS
  After the procedure, serum Crea values were higher in group II compared with group I (p = 0.051). Postprocedural 48-h GFR values determined by Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) equations were lower in group II compared with group I (p = 0.016 and p = 0.003, respectively). Delta (Δ) ΔCrea and ΔGFR determined by the Cockcroft-Gault and MDRD equations were statistically higher in group II than in group I (p = 0.005, p = 0.052, p = 0.030). The presence of higher age (p = 0.025), E/E' lateral ratio (p = 0.030), and left atrial volume index (p = 0.05) were independent predictors of worsening renal function.
  
  
  CONCLUSIONS
  The presence of diastolic dysfunction may play a role in determining the risk of CIN in patients with normal LVEF.
authors.affiliation: Department of Cardiology, Ministry of Health Dışkapı Yıldırım Beyazıt Research and Educational Hospital, 06110, Ankara, Turkey, sadik.acikel@tkd.org.tr.
authors.forename: S
authors.initials: S
authors.lastname: Acikel
authors.forename: R
authors.initials: R
authors.lastname: Akdemir
authors.forename: H
authors.initials: H
authors.lastname: Kilic
authors.forename: G
authors.initials: G
authors.lastname: Cagirci
authors.forename: M
authors.initials: M
authors.lastname: Dogan
authors.forename: A B
authors.initials: AB
authors.lastname: Yesilay
authors.forename: E
authors.initials: E
authors.lastname: Yeter
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003287:Contrast Media / Q000009:adverse effects; D017023:Coronary Angiography / Q000009:adverse effects; D004452:Echocardiography / Q000379:methods; D007472:Iohexol / Q000009:adverse effects; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis; D018570:Risk Assessment; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D007472:Iohexol