title: Endoplasmic reticulum stress is induced in the human placenta during labour.
abstract: Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2α and XBP-1, were significantly higher in laboured placentas than in Caesarean-delivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas.
authors.affiliation: Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK; University Medical Center Utrecht, Division of Perinatology, Department of Obstetrics, The Netherlands. Electronic address: jhwv2@cam.ac.uk.
authors.forename: J H W
authors.initials: JH
authors.lastname: Veerbeek
authors.affiliation: Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Tissot Van Patot
authors.affiliation: Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK.
authors.forename: G J
authors.initials: GJ
authors.lastname: Burton
authors.affiliation: Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK.
authors.forename: H W
authors.initials: HW
authors.lastname: Yung
mesh_terms: D002585:Cesarean Section; D004268:DNA-Binding Proteins / Q000378:metabolism; D000091342:Endoplasmic Reticulum Chaperone BiP; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D036801:Parturition / Q000378:metabolism*; D010766:Phosphorylation; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000378:metabolism; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000091342:Endoplasmic Reticulum Chaperone BiP; D015852:Eukaryotic Initiation Factor-2; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human
keywords: Endoplasmic reticulum stress; Labour; Placenta