title: A nickel-mediated oxidative α-C(sp(3))-H functionalization of amides with allylic alcohols terminated by radical 1,2-aryl migration.
abstract: A Ni-mediated oxidative C(sp(3))-H functionalization of N,N-substituted amides with α,α-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, γ-amino ketones containing an all-carbon quaternary center were synthesized under these conditions in moderate to good yields.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. tuyq@lzu.edu.cn.
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Dao-Yong
authors.initials: DY
authors.lastname: Zhu
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry*
chemical_list: D000577:Amides; D006841:Hydrocarbons, Aromatic; D020005:Propanols; C006463:allyl alcohol; D009532:Nickel