title: Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy.
abstract: Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is highly resistant to proteases and shows minimal toxicity, paving the way for prophylactic or therapeutic application of the peptide in vivo.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA Department of Bioengineering, University of Illinois at Chicago, Illinois, USA Department of Pathology, University of Illinois, Chicago, Illinois, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Jaishankar
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago, Illinois, USA Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois, USA.
authors.forename: Abraam M
authors.initials: AM
authors.lastname: Yakoub
authors.affiliation: Department of Pathology, University of Illinois, Chicago, Illinois, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Bogdanov
authors.affiliation: Department of Pathology, University of Illinois, Chicago, Illinois, USA.
authors.forename: Tibor
authors.initials: T
authors.lastname: Valyi-Nagy
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA Department of Bioengineering, University of Illinois at Chicago, Illinois, USA Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois, USA dshukla@uic.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Shukla
mesh_terms: D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D010447:Peptide Hydrolases / Q000378:metabolism; D059748:Proteolysis; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D009842:Oligopeptides; D010447:Peptide Hydrolases