title: Erdheim-Chester disease with rare radiological features in a 14-year old girl with pre-B Acute Lymphocytic Leukemia and Diabetes Mellitus.
abstract: We report a case of a 14 year-old girl with Diabetes Mellitus who was in remission with pre-B cell Acute Lymphoblastic Leukemia and subsequently diagnosed with Erdheim-Chester disease. Erdheim-Chester disease is a non-Langerhans cell histiocytosis and is very rare in children. In addition, the radiological features of the lesions are atypical and have not been reported in children. There is no known association between the three conditions and this is the first reported case in the literature. A literature review of Erdheim-Chester disease will be performed.
authors.affiliation: Department of Diagnostic Imaging, KK Women's and Children's Hospital, Singapore.
authors.forename: Varanasi Venkata Rama
authors.initials: VV
authors.lastname: Krishna
authors.affiliation: Department of Diagnostic Imaging, KK Women's and Children's Hospital, Singapore.
authors.forename: Teo Eu Leong Harvey
authors.initials: TE
authors.lastname: James
authors.affiliation: Department of Pathology and laboratory medicine, KK Women's and Children's Hospital, Singapore.
authors.forename: Kenneth Tou En
authors.initials: KT
authors.lastname: Chang
authors.affiliation: Department of Hematology and Oncology, KK Women's and Children's Hospital, Singapore.
authors.forename: Soh Shui
authors.initials: SS
authors.lastname: Yen
mesh_terms: D000293:Adolescent; D050280:Arm Bones / Q000000981:diagnostic imaging; D001921:Brain / Q000473:pathology; D048909:Diabetes Complications; D003937:Diagnosis, Differential; D031249:Erdheim-Chester Disease / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007867:Leg Bones / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012886:Skull / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
keywords: Erdheim-Chester disease; Interferon alpha; Langerhans cell histiocytosis; Touton type giant cells; osteolytic lesions