title: Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy.
abstract: The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.
authors.affiliation: Department of Medicine/Nephrology, Hannover Medical School , Hannover , Germany.
authors.forename: Beina
authors.initials: B
authors.lastname: Teng
authors.affiliation: Department of Medicine/Nephrology, Hannover Medical School , Hannover , Germany.
authors.forename: Michelle
authors.initials: M
authors.lastname: Duong
authors.affiliation: Department of Medicine/Nephrology, Hannover Medical School , Hannover , Germany.
authors.forename: Irini
authors.initials: I
authors.lastname: Tossidou
authors.affiliation: Department of Medicine/Nephrology, Hannover Medical School , Hannover , Germany.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Medicine/Nephrology, Hannover Medical School , Hannover , Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Schiffer
keywords: diabetic podocytopathy; effacement; glomerulosclerosis; nephrin endocytosis; proteinuria