title: A new method of building permanent A-V block model: ablating his-bundle potential through femoral artery with pre-implanted biventricular pacemaker.
abstract: BACKGROUND
  To explore the feasibility of a new method of achieving a permanent A-V block animal model.
  
  
  METHODS
  16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the aortic sinus, through femoral artery. (2) In the second group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the triangle of Koch, through femoral vein. A complete A-V block model was achieved as a standard in this study. The success rates, intraoperative arrhythmias, operative and X-ray exposure time, intraoperative bleeding amount were assessed in this two groups, both animal models were followed up for four weeks and then fasted to monitor myocardial pathological changes.
  
  
  RESULTS
  The success rate of the first group, which with fewer intraoperative arrhythmias, and less operative and X-ray exposure time, was significantly higher than the second group.
  
  
  CONCLUSIONS
  Compared with traditional animal method, our new method of ablating his-bundle potential at the left ventricle from the femoral artery has a higher success rate, fewer occurrence of malignant arrhythmias, and less operation and X-ray time. Thus, our new method should be preferred in the building of Permanent A-V Block Model.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cheng
authors.forename: Ye
authors.initials: Y
authors.lastname: Hai-ge
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Ye
authors.initials: Y
authors.lastname: Wan-chun
authors.forename: Wang
authors.initials: W
authors.lastname: Lu-ping
authors.forename: Li
authors.initials: L
authors.lastname: Yue-chun
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang, China. linjiafeng_wzmcfey@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia-Feng
mesh_terms: D000818:Animals; D054537:Atrioventricular Block / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D002036:Bundle of His / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D058406:Cardiac Resynchronization Therapy; D058409:Cardiac Resynchronization Therapy Devices; D017115:Catheter Ablation / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005240:Feasibility Studies; D005263:Femoral Artery; D005268:Femoral Vein; D008297:Male