title: Ethnic disparities in the risk of colorectal adenomas associated with lipid levels: a retrospective multiethnic study.
abstract: BACKGROUND
  Although data exists showing that uncontrolled lipid levels in white and black patients is associated with colorectal adenomas, there are currently no studies looking only at the Hispanic population.
  
  
  OBJECTIVE
  With the rapid increase in the Hispanic population, we aimed to look at their risk of colorectal adenomas in association with lipid levels.
  
  
  METHODS
  We retrospectively analyzed 1473 patients undergoing colonoscopy from 2009 to 2011 at a community hospital. Statistical analysis was performed using Chi-squared for categorical variables and t test for continuous variables with age-, gender-, and race-adjusted odds ratios. Unconditional logistic regression model was used to estimate 95 % confidence intervals (CI). SAS 9.3 software was used to perform all statistical analysis.
  
  
  RESULTS
  In our general population, there was an association with elevated triglyceride levels greater than 150 and presence of multiple colorectal adenomas with odds ratio (OR) 1.60 (1.03, 2.48). There was an association with proximal colon adenomas and cholesterol levels between 200 and 239 with OR 1.57 (1.07, 2.30), and low-density lipoprotein (LDL) levels of greater than 130 with OR 1.54 (1.04, 2.30). There was no association between high-density lipoproteins (HDL) levels and colorectal adenomas. The Hispanic population showed no statistical correlation between elevated triglycerides, cholesterol, or LDL with the presence, size, location, or multiplicity of colorectal adenomas.
  
  
  CONCLUSIONS
  We found a significant correlation between elevated lipid levels and colorectal adenomas in white and black patients; however, there was no such association in the Hispanic population. This finding can possibly be due to environmental factors such as dietary, colonic flora, or genetic susceptibility, which fosters further investigation and research.
authors.affiliation: Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA, adavis3@health.usf.edu.
authors.forename: Ashley H
authors.initials: AH
authors.lastname: Davis-Yadley
authors.forename: Seth
authors.initials: S
authors.lastname: Lipka
authors.forename: Huafeng
authors.initials: H
authors.lastname: Shen
authors.forename: Valerie
authors.initials: V
authors.lastname: Devanney
authors.forename: Supreeya
authors.initials: S
authors.lastname: Swarup
authors.forename: Alex
authors.initials: A
authors.lastname: Barnowsky
authors.forename: Jeff
authors.initials: J
authors.lastname: Silpe
authors.forename: Josh
authors.initials: J
authors.lastname: Mosdale
authors.forename: Qinshi
authors.initials: Q
authors.lastname: Pan
authors.forename: Svetlana
authors.initials: S
authors.lastname: Fridlyand
authors.forename: Suhas
authors.initials: S
authors.lastname: Sreeharshan
authors.forename: Albin
authors.initials: A
authors.lastname: Abraham
authors.forename: Prakash
authors.initials: P
authors.lastname: Viswanathan
authors.forename: Bhuma
authors.initials: B
authors.lastname: Krishnamachari
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D008055:Lipids