title: Diverse roles of LPA signaling in the intestinal epithelium.
abstract: Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signaling in the intestinal tract.
authors.affiliation: Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; Atlanta VA Medical Center, Decatur, GA, USA. Electronic address: ccyun@emory.edu.
authors.forename: C Chris
authors.initials: CC
authors.lastname: Yun
authors.affiliation: Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001692:Biological Transport; D002450:Cell Communication; D015179:Colorectal Neoplasms / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008246:Lysophospholipids / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid
keywords: Colon cancer; Inflammation; Intestine; Lysophosphatidic acid