title: Radiotherapy-induced hearing loss in patients with laryngeal and hypopharyngeal carcinomas.
abstract: The purpose of this study was to investigate a hypothesized correlation of development of a sensorineural hearing loss and radiotherapy in patients with laryngeal and hypopharyngeal carcinoma. This prospective study included a total of 50 patients, which after strict exclusion critera (audiologic problems before RT primary tumors of the auditory system, spread of the primary tumor to any part of the auditory system) resulted in 23 analyzed patients, ranging between 50 and 76 years of age, with a mean age of 60. Audiometry measuring frequency-specific thresholds was performed in three time points: one month before radiotherapy, one and six months after radiotherapy. A significant statistical difference in hearing tresholds after radiotherapy was found in 6 out of 23 patients. An obvious tendency towards hearing loss without statistical significance at 250 and 4000 Hz was found for a whole tested population (p < or = 0.3 with Bonferroni correction). Observed tendency towards hearing loss after radiotherapy of laryngeal carcinoma was related to side of the tumor and less severe when chemotherapy was not added as adjuvant therapy. These results should help to decrease a rate of hearing loss by careful planing of ear protection, by using observed frequencies as relevant markers of hearing loss and by reconsidering adjuvant chemoterapy during radiotherapy of laryngeal carcinoma.
authors.forename: Goran
authors.initials: G
authors.lastname: Gudelj
authors.forename: Robert
authors.initials: R
authors.lastname: Trotić
authors.forename: Tonko
authors.initials: T
authors.lastname: Herceg
authors.forename: Domagoj
authors.initials: D
authors.lastname: Parazajder
authors.forename: Davor
authors.initials: D
authors.lastname: Vagić
authors.forename: Goran
authors.initials: G
authors.lastname: Geber
mesh_terms: D000368:Aged; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000532:radiotherapy*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects