title: Rheb G-Proteins and the Activation of mTORC1.
abstract: Rheb belongs to a unique family within the Ras superfamily of G-proteins. Although initially identified in rat brain, this G-protein is highly conserved from yeast to human. While only one Rheb is present in lower eukaryotes, two Rheb proteins exist in mammalian cells. A number of studies establish that one of the functions of Rheb is to activate mTOR leading to growth. In particular, the ability of Rheb to activate mTORC1in vitropoints to direct interaction of Rheb with the mTORC1 complex. Additional functions of Rheb that are independent of mTOR have also been suggested.
authors.affiliation: Biology Program, California State University Channel Islands, 1 University Drive, Camarillo, California, USA.
authors.forename: Nitika
authors.initials: N
authors.lastname: Parmar
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi