title: Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
abstract: Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.
authors.affiliation: 1] Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [3] Present address: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Holland
authors.affiliation: Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK.
authors.forename: Mercede A
authors.initials: MA
authors.lastname: Pannozzo
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Scottish Imaging Network, A Platform for Scientific Collaboration (SINAPSE), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bastin
authors.affiliation: Diabetic and Cardiovascular Medicine, University of Dundee, Dundee, UK.
authors.forename: Allison D
authors.initials: AD
authors.lastname: McNeilly
authors.affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Ferguson
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Caughey
authors.affiliation: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Maurits A
authors.initials: MA
authors.lastname: Jansen
authors.affiliation: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Gavin D
authors.initials: GD
authors.lastname: Merrifield
authors.affiliation: Scottish Imaging Network, A Platform for Scientific Collaboration (SINAPSE), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Marshall
authors.affiliation: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
authors.forename: John J
authors.initials: JJ
authors.lastname: Mullins
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Scottish Imaging Network, A Platform for Scientific Collaboration (SINAPSE), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Wardlaw
authors.affiliation: Diabetic and Cardiovascular Medicine, University of Dundee, Dundee, UK.
authors.forename: Calum
authors.initials: C
authors.lastname: Sutherland
authors.affiliation: 1] Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Horsburgh
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D055647:Rats, Transgenic; D012083:Renin / Q000096:biosynthesis / Q000235:genetics; D066127:White Matter / Q000378:metabolism* / Q000473:pathology
chemical_list: D004041:Dietary Fats; C473112:Ren2 protein, mouse; D019363:Cytochrome P-450 CYP1A1; D012083:Renin