title: N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
abstract: On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
authors.affiliation: Laboratorio de Química Médica, (IQOG, CSIC) , Juan de la Cierva 3, E-28006 Madrid, Spain.
authors.forename: Oscar M
authors.initials: OM
authors.lastname: Bautista-Aguilera
authors.forename: Abdelouahid
authors.initials: A
authors.lastname: Samadi
authors.forename: Mourad
authors.initials: M
authors.lastname: Chioua
authors.forename: Katarina
authors.initials: K
authors.lastname: Nikolic
authors.forename: Slavica
authors.initials: S
authors.lastname: Filipic
authors.forename: Danica
authors.initials: D
authors.lastname: Agbaba
authors.forename: Elena
authors.initials: E
authors.lastname: Soriano
authors.forename: Lucía
authors.initials: L
authors.lastname: de Andrés
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Rodríguez-Franco
authors.forename: Stefano
authors.initials: S
authors.lastname: Alcaro
authors.forename: Rona R
authors.initials: RR
authors.lastname: Ramsay
authors.forename: Francesco
authors.initials: F
authors.lastname: Ortuso
authors.forename: Matilde
authors.initials: M
authors.lastname: Yañez
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002463:Cell Membrane Permeability / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D002802:Cholinesterases / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000737:chemistry*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013552:Swine
chemical_list: D002800:Cholinesterase Inhibitors; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; C000595873:N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine; D010880:Piperidines; D008995:Monoamine Oxidase; D002802:Cholinesterases