title: Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding.
abstract: The ability to form long-term memories for novel events depends on information processing within the hippocampus (HC) and entorhinal cortex (EC). The HC-EC circuitry shows a quantitative segregation of anatomical directionality into different neuronal layers. Whereas superficial EC layers mainly project to dentate gyrus (DG), CA3 and apical CA1 layers, HC output is primarily sent from pyramidal CA1 layers and subiculum to deep EC layers. Here we utilize this directionality information by measuring encoding activity within HC/EC subregions with 7 T high resolution functional magnetic resonance imaging (fMRI). Multivariate Bayes decoding within HC/EC subregions shows that processing of novel information most strongly engages the input structures (superficial EC and DG/CA2-3), whereas subsequent memory is more dependent on activation of output regions (deep EC and pyramidal CA1). This suggests that while novelty processing is strongly related to HC-EC input pathways, the memory fate of a novel stimulus depends more on HC-EC output.
authors.affiliation: Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Maass
authors.affiliation: Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Schütze
authors.affiliation: 1] Biomedical Magnetic Resonance, Institute of Experimental Physics, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg, 39120 Magdeburg, Germany [3] Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany [4] Center for Behavioral and Brain Sciences, CBBS, 39120 Magdeburg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Speck
authors.affiliation: Department of Psychology, Center for Mind and Brain, University of California, Davis, California 95616, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Yonelinas
authors.affiliation: Department of Neurology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Tempelmann
authors.affiliation: 1] German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg, 39120 Magdeburg, Germany [2] Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany [3] Center for Behavioral and Brain Sciences, CBBS, 39120 Magdeburg, Germany [4] Department of Neurology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Hans-Jochen
authors.initials: HJ
authors.lastname: Heinze
authors.affiliation: Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Berron
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg, 39120 Magdeburg, Germany.
authors.forename: Arturo
authors.initials: A
authors.lastname: Cardenas-Blanco
authors.affiliation: Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich Ð Zurich, 8032 Zurich, Switzerland.
authors.forename: Kay H
authors.initials: KH
authors.lastname: Brodersen
authors.affiliation: 1] Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich Ð Zurich, 8032 Zurich, Switzerland [2] Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK.
authors.forename: Klaas Enno
authors.initials: KE
authors.lastname: Stephan
authors.affiliation: 1] Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg, 39120 Magdeburg, Germany [3] Center for Behavioral and Brain Sciences, CBBS, 39120 Magdeburg, Germany [4] Department of Neurology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany [5] Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK.
authors.forename: Emrah
authors.initials: E
authors.lastname: Düzel
mesh_terms: D000328:Adult; D018728:Entorhinal Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009434:Neural Pathways; D011859:Radiography; D055815:Young Adult