title: Single-center experience of transplantation for polycystic liver disease.
abstract: BACKGROUND
  Polycystic liver disease (PLD) may lead to massive hepatomegaly, abdominal distension, pain, and various degrees of dyspnea. The surgical treatment of this entity remains controversial.
  
  
  METHODS
  We report our experience from a retrospective analysis of 23 patients suffering from PLD who were treated with liver transplantation (LT) in our institution.
  
  
  RESULTS
  Liver transplantation for PLD patients with extensive hepatic involvement offers excellent symptoms relief. The actuarial 1-, 3-, and 5-year survival rate after transplantation was 86%.
  
  
  CONCLUSIONS
  Our experience demonstrates that PLD patients with extensive hepatic involvement and who are treated with LT have good long-term prognosis and excellent symptoms relief. LT might be considered in severe PLD cases where conventional surgery is not a curative option, and it must be balanced against the risks of LT and lifelong commitment to immunosuppression.
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Vernadakis
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Moris
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany. Electronic address: george.mamarelis@hotmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Mamarelis
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Fouzas
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: Z
authors.initials: Z
authors.lastname: Mathe
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kaiser
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Sotiropoulos
mesh_terms: D000328:Adult; D000368:Aged; D003560:Cysts / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008107:Liver Diseases / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors