title: Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction.
abstract: OBJECTIVE
  Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children.
  
  
  METHODS
  31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5-16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI).
  
  
  RESULTS
  The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥ 50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25-50%), and three children showed no response at all (< 25%).
  
  
  CONCLUSIONS
  A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids.
authors.affiliation: Department of Pediatrics, Medisch Spectrum Twente, KA Enschede, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Visser
authors.affiliation: Department of Emergency, Röpcke-Zweers Hospital, Hardenberg, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Wind
authors.affiliation: Department of Pediatrics, Medisch Spectrum Twente, KA Enschede, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: de Graaf
authors.affiliation: Department of Pulmonary Function, Medisch Spectrum Twente, Enschede, The Netherlands.
authors.forename: F H C
authors.initials: FH
authors.lastname: de Jongh
authors.affiliation: Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands.|Department of Research Methodology, Measurement and Data Analysis, University of Twente, Enschede, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van der Palen
authors.affiliation: Department of Pediatrics, Medisch Spectrum Twente, KA Enschede, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Thio
mesh_terms: D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000517:prevention & control*; D001507:Beclomethasone / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D011446:Prospective Studies
chemical_list: D005938:Glucocorticoids; D001507:Beclomethasone
keywords: Pediatric asthma; exercise induced asthma; inhaled corticosteroids; protection