title: Rsp5/Nedd4 clears cells of heat-damaged proteins.
abstract: Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sommer
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Weber
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Jarosch
mesh_terms: D000818:Animals; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics* / Q000378:metabolism*; D050956:HSP40 Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D000075702:Nedd4 Ubiquitin Protein Ligases; D017510:Protein Folding; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D050956:HSP40 Heat-Shock Proteins; D029701:Saccharomyces cerevisiae Proteins; C070319:YDJ1 protein, S cerevisiae; D043743:Ubiquitin-Protein Ligase Complexes; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618483:Nedd4 protein, human; D044767:Ubiquitin-Protein Ligases; C469287:RSP5 protein, S cerevisiae