title: Relating external compressing pressure to mean arterial pressure in non-invasive blood pressure measurements.
abstract: Arterial volume clamping uses external compression of an artery to provide continuous non-invasive measurement of arterial blood pressure. It has been assumed that mean arterial pressure (MAP) corresponds to the point where unloading leads to the maximum oscillation of the arterial wall as reflected by photoplethysmogram (PPG), an assumption that has been challenged. Five subjects were recruited for the study (three males, mean age (SD) = 32 (15) years). The PPG waveform was analysed to identify the relationship between the external compressing pressure, PPG pulse amplitude and MAP. Two separate tests were carried out at compression step intervals of 10 mmHg and 2 mmHg, respectively. No significant differences were found between the two tests. The bias between the compressing pressure and the MAP was -4.7 ± 5.63 mmHg (p < 0.001) showing a normal distribution. Further research is needed to identify optimal algorithms for estimation of MAP using PPG associated with arterial compression.
authors.affiliation: Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary , Leicester LE1 5WW , UK .
authors.forename: K Y
authors.initials: KY
authors.lastname: Chin
authors.forename: R B
authors.initials: RB
authors.lastname: Panerai
mesh_terms: D000293:Adolescent; D000328:Adult; D062186:Arterial Pressure / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017156:Photoplethysmography / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: Blood pressure; non-invasive; photoplethysmography; pulse amplitude; volume clamping technique