title: Multimodal treatment of aggressive forms of breast cancer.
abstract: Aggressive breast cancer is an invasive form with G3, G4 differentiation degree, the absence of receptors for estrogen and progesterone and the absence or presence of HER2 (+ or 3+) gene. The final diagnosis is established by cumulating the clinical, paraclinical, histopathological and immunohistochemical diagnosis.
  
  
  METHODS
  84 out of 268 aggressive breast cancer cases were presented in the study, which were operated in October 2011-September 2013. The inclusion and exclusion criteria are exposed in the study lot and the treatment schemes.
  
  
  RESULTS
  For the study lot (lot A made up of 36 cases, lot B made up of 41 cases, lot C made up of 7 cases) the distribution was presented on age groups, histopathological and immunohistochemical classification, etiologic factors, type of surgery, postoperative staging and complications.
  
  
  CONCLUSIONS
  The treatment of aggressive breast cancer depends on the level of the aggressiveness of the disease, the biologic status and the age that imposes the order of chemotherapy, radiotherapy, surgical treatment and target therapy.
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: D
authors.initials: D
authors.lastname: Mihai
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: S
authors.initials: S
authors.lastname: Voiculescu
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: D
authors.initials: D
authors.lastname: Cristian
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: F
authors.initials: F
authors.lastname: Constantinescu
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: E
authors.initials: E
authors.lastname: Popa
authors.affiliation: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors.forename: T
authors.initials: T
authors.lastname: Burcos
mesh_terms: D000367:Age Factors; D001943:Breast Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008408:Mastectomy / Q000379:methods*; D020360:Neoadjuvant Therapy / Q000379:methods*
keywords: differentiation degree; invasive form; progesterone and HER2; receptors for estrogen