title: Mosquito immunity against arboviruses.
abstract: Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing human disease with increasing geographic range and severity. The recent availability of the genome sequences of medically important mosquito species has kick-started investigations into the molecular basis of how mosquito vectors control arbovirus infection. Here, we discuss recent findings concerning the role of the mosquito immune system in antiviral defense, interactions between arboviruses and fundamental cellular processes such as apoptosis and autophagy, and arboviral suppression of mosquito defense mechanisms. This knowledge provides insights into co-evolutionary processes between vector and virus and also lays the groundwork for the development of novel arbovirus control strategies that target the mosquito vector.
authors.affiliation: Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. shuzhens@gis.a-star.edu.sg.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Sim
authors.affiliation: Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. njupata1@jhu.edu.
authors.forename: Natapong
authors.initials: N
authors.lastname: Jupatanakul
authors.affiliation: Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. gdimopo1@jhu.edu.
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos
mesh_terms: D000818:Animals; D017209:Apoptosis; D001103:Arboviruses / Q000502:physiology*; D001343:Autophagy; D005075:Biological Evolution; D009033:Culicidae / Q000276:immunology / Q000821:virology*; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007303:Insect Vectors / Q000821:virology*