title: Helicobacter pylori infection and insulin resistance in diabetic and nondiabetic population.
abstract: Helicobacter pylori (HP) is a common worldwide infection with known gastrointestinal and nongastrointestinal complications. One of the gastrointestinal side effects posed for this organism is its role in diabetes and increased insulin resistance. The aim of this study was to evaluate the association between HP and insulin resistance in type 2 diabetic patients and nondiabetics. This cross-sectional study was carried out from May to December 2013 on 211 diabetic patients referred to diabetes clinic of Shahid Beheshti Hospital of Qom and 218 patients without diabetes. HP was evaluated using serology method and insulin resistance was calculated using HOMA-IR. The prevalence of H. pylori infection was 55.8% and 44.2% in diabetics and nondiabetics (P = 0.001). The study population was divided into two HP positive and negative groups. Among nondiabetics, insulin resistance degree was 3.01 ± 2.12 and 2.74 ± 2.18 in HP+ and HP- patients, respectively (P = 0.704). Oppositely, insulin resistance was significantly higher in diabetic HP+ patients rather than seronegative ones (4.484 ± 2.781 versus 3.160 ± 2.327, P = 0.013). In diabetic patients, in addition to higher prevalence of HP, it causes a higher degree of insulin resistance.
authors.affiliation: Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Jamshid
authors.identifier: 0000-0002-9063-2639
authors.initials: J
authors.lastname: Vafaeimanesh
authors.affiliation: Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Mahmoud
authors.identifier: 0000-0001-5400-7900
authors.initials: M
authors.lastname: Parham
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Mohammadreza
authors.identifier: 0000-0002-5264-6706
authors.initials: M
authors.lastname: Seyyedmajidi
authors.affiliation: Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bagherzadeh
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D015444:Exercise; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance; D007492:Iran; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides