title: [Research progress on the relationship between SLCO1B1 gene and neonatal jaundice].
abstract: Organic anion transporter 2 (OATP2) is an uptake transporter located on the basolateral membrane of human hepatocytes. It mediates the transportation of various organic solutes including bilirubin and impacts bilirubin metabolism. It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the gene variants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin elimination and result in neonatal hyperbilirubinemia. In recent years, some studies have indicated that variants of SLCO1B1 are associated with neonatal jaundice. This article reviews the research advance in SLCO1B1 with respect to the structure and function and the relationship between SLCO1B1 mutations and neonatal jaundice.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. danny5911@163.com.
authors.forename: An-Feng
authors.initials: AF
authors.lastname: Lu
authors.forename: Dan-Ni
authors.initials: DN
authors.lastname: Zhong
mesh_terms: D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000235:genetics*; D027381:Liver-Specific Organic Anion Transporter 1 / Q000235:genetics; D027361:Organic Anion Transporters / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human