title: Formulation of budesonide mouthwash for the treatment of oral chronic graft-versus-host disease.
abstract: Oral involvement is (very) common in chronic graft-versus-host disease and can cause discomfort and impairment of oral function. Budesonide, a highly potent corticosteroid with low systemic activity, can be used as a topical treatment for oral chronic graft-versus-host disease. We describe the development of a formulation of budesonide and sodium bicarbonate for use as mouthwash in patients with oral chronic graft-versus-host disease.
authors.affiliation: Department of Hematology and Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Belgium guy.vanschandevyl@huderf.be.
authors.forename: Guy
authors.initials: G
authors.lastname: Van Schandevyl
authors.affiliation: Department of Pharmacy, Ghent University Hospital, Belgium.
authors.forename: Tiene
authors.initials: T
authors.lastname: Bauters
mesh_terms: D000287:Administration, Topical; D019819:Budesonide / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D006086:Graft vs Host Disease / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D009067:Mouthwashes; D019819:Budesonide
keywords: Stem cell transplantation; budesonide; children; chronic; formulation; graft-versus-host disease; mouthwash; oral; rinse; sodium bicarbonate; steroid; topical