title: Factors influencing the durability of the glucose-lowering effect of sitagliptin combined with a sulfonylurea.
abstract: We analyzed the changes of glycemic control over 12 months and the factors influencing blood glucose in 162 Japanese patients with type 2 diabetes having inadequate glycemic control despite sulfonylurea-based therapy who received add-on sitagliptin. Hemoglobin A1c (HbA1c) decreased significantly after 4 weeks of treatment, and this improvement was maintained for 1 year, although HbA1c was slightly higher in week 52 than in week 24. Comparison of the patients showing a ≥0.4% increase of HbA1c between weeks 24 and 52 (n = 57) with the others (n = 105) showed a significant difference in the change of bodyweight, as well as the dose of glibenclamide (both P < 0.01). Although combined therapy with sitagliptin and a sulfonylurea seems to be effective for at least 1 year, blood glucose levels are more likely to increase again in patients who show greater weight gain after 24 weeks of treatment and those receiving a higher dose of glibenclamide.
authors.affiliation: Kubota Clinic of Internal Medicine Kawasaki city Kanagawa Japan ; Kansai Electric Power Hospital Osaka city Osaka Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kubota
authors.affiliation: Kansai Electric Power Hospital Osaka city Osaka Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yabe
authors.affiliation: Kanamori Diabetes Clinic Sagamihara city Kanagawa Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kanamori
authors.affiliation: Hikone Municipal Hospital Hikone city Shiga Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kuroe
authors.affiliation: Takahashi Family Clinic Nagoya city Aichi Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Kobari General Hospital Noda city Chiba Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Saito
authors.affiliation: Matsuba Clinic Kawasaki city Kanagawa Japan.
authors.forename: Ikuro
authors.initials: I
authors.lastname: Matsuba
authors.affiliation: Kubota Clinic of Internal Medicine Kawasaki city Kanagawa Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Nabe
authors.affiliation: Kansai Electric Power Hospital Osaka city Osaka Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurose
authors.affiliation: Kansai Electric Power Hospital Osaka city Osaka Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
keywords: Blood glucose; Sitagliptin; Sulfonylurea