title: Complex differential variance algorithm for optical coherence tomography angiography.
abstract: We describe a complex differential variance (CDV) algorithm for optical coherence tomography based angiography. The algorithm exploits both the intensity and phase changes of optical coherence tomography (OCT) signals from flowing blood to achieve high vascular contrast, and also intrinsically reject undesirable phase signals originating from small displacement axial bulk tissue motion and instrument synchronization errors. We present this algorithm within a broader discussion of the properties of OCT signal dynamics. The performance of the algorithm is compared against two other existing algorithms using both phantom measurements and in vivo data. We show that the algorithm provides better contrast for a given number of measurements and equivalent spatial averaging.
authors.affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA ; Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA.
authors.forename: Ahhyun S
authors.initials: AS
authors.lastname: Nam
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA ; Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Chico-Calero
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA ; Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA ; Department of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts 02139, USA.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Vakoc
keywords: (170.3010) Image reconstruction techniques; (170.4500) Optical coherence tomography