title: Chromium exposure and germinal embryonal carcinoma: first two cases and review of the literature.
abstract: The aim of the study was to determine the potential role of occupational exposures to chromium (Cr) in the onset of extragonadal germinal embryonal carcinoma. The first two cases of workers in a company with Cr exposure are reported. The published scientific literature regarding the topic in peer-reviewed journals including MEDLINE and CancerLit databases was extensively reviewed. Two young patients who were coworkers in the same company, exposed to Cr, developed extragonadal germinal embryonal carcinomas. One of them also developed angiosarcoma of the mediastinum. To the best of our knowledge these are the first two cases of germinal embryonal carcinoma in patients with occupational exposure to Cr.
authors.affiliation: a Medical Oncology , Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G Salesi , Ancona , Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Berardi
authors.forename: Chiara
authors.initials: C
authors.lastname: Pellei
authors.forename: Gianluca
authors.initials: G
authors.lastname: Valeri
authors.forename: Mirco
authors.initials: M
authors.lastname: Pistelli
authors.forename: Azzurra
authors.initials: A
authors.lastname: Onofri
authors.forename: Francesca
authors.initials: F
authors.lastname: Morgese
authors.forename: Miriam
authors.initials: M
authors.lastname: Caramanti
authors.forename: Riccardo Mashadi
authors.initials: RM
authors.lastname: Mirza
authors.forename: Matteo
authors.initials: M
authors.lastname: Santoni
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: De Lisa
authors.forename: Agnese
authors.initials: A
authors.lastname: Savini
authors.forename: Zelmira
authors.initials: Z
authors.lastname: Ballatore
authors.forename: Gian Marco
authors.initials: GM
authors.lastname: Giuseppetti
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018236:Carcinoma, Embryonal / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D002857:Chromium / Q000633:toxicity*; D002945:Cisplatin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D002857:Chromium; D002945:Cisplatin