title: Multi-center randomized open label phase II trial on three rituximab dosing schemes in immune thrombocytopenia patients.
authors.affiliation: Dept. of Immunohematology and Blood Transfusion, Leiden University Medical Center and the Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, The Netherlands j.j.zwaginga@lumc.nl.
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: Zwaginga
authors.affiliation: HOVON Data Center, Erasmus MC Cancer Institute - Clinical Trial Center, Rotterdam.
authors.forename: Bronno
authors.initials: B
authors.lastname: van der Holt
authors.affiliation: Dept. of Hematology, Erasmus MC, Rotterdam.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Te Boekhorst
authors.affiliation: Dept. of Hematology, Academic Medical Center Amsterdam, The Netherlands.
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Biemond
authors.affiliation: Dept. of Internal Medicine, Albert Schweitzer Hospital, Dordrecht.
authors.forename: Mark-David
authors.initials: MD
authors.lastname: Levin
authors.affiliation: Department of Internal Medicine, Diakonessenhuis, Utrecht.
authors.forename: René
authors.initials: R
authors.lastname: van der Griend
authors.affiliation: Dept. of Immunohematology and Blood Transfusion, Leiden University Medical Center and the Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, The Netherlands.
authors.forename: Anneke
authors.initials: A
authors.lastname: Brand
authors.affiliation: Dept. of Hematology, VU University Medical Center, Amsterdam.
authors.forename: Sonja
authors.initials: S
authors.lastname: Zweegman
authors.affiliation: Dept. of Internal Medicine, Jeroen Bosch Hospital, Den Bosch.
authors.forename: Hans F M
authors.initials: HF
authors.lastname: Pruijt
authors.affiliation: Dept. of Hematology, Radboud University Medical Centre, Nijmegen.
authors.forename: Vera M J
authors.initials: VM
authors.lastname: Novotny
authors.affiliation: Dept of Internal Medicine, Máxima Medical Center, Veldhoven.
authors.forename: Art
authors.initials: A
authors.lastname: Vreugdenhil
authors.affiliation: Dept. of Internal Medicine, Medisch Spectrum Twente, Enschede.
authors.forename: Marco R
authors.initials: MR
authors.lastname: de Groot
authors.affiliation: Dept. of Internal Medicine, St. Antonius Hospital, Nieuwegein.
authors.forename: Okke
authors.initials: O
authors.lastname: de Weerdt
authors.affiliation: Dept. of Laboratory Medicine, Radboud University Medical Center, Nijmegen.
authors.forename: Elisabeth C M
authors.initials: EC
authors.lastname: van Pampus
authors.affiliation: Dept. of Internal Medicine, Westfriesgasthuis, Hoorn.
authors.forename: Tanja M
authors.initials: TM
authors.lastname: van Maanen-Lamme
authors.affiliation: Dept. of Internal Medicine, Meander Hospital, Amersfoort.
authors.forename: Shulamiet
authors.initials: S
authors.lastname: Wittebol
authors.affiliation: Dept. of Internal Medicine, HagaZiekenhuis, Den Haag.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Schipperus
authors.affiliation: Dept. of Internal Medicine, Tergooiziekenhuizen, Blaricum.
authors.forename: Matthijs H
authors.initials: MH
authors.lastname: Silbermann
authors.affiliation: Dept. of Hematology, VU University Medical Center, Amsterdam.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Huijgens
authors.affiliation: HOVON Data Center, Erasmus MC Cancer Institute - Clinical Trial Center, Rotterdam.
authors.forename: Marleen
authors.initials: M
authors.lastname: Luten
authors.affiliation: HOVON Data Center, Erasmus MC Cancer Institute - Clinical Trial Center, Rotterdam.
authors.forename: Rene
authors.initials: R
authors.lastname: Hollestein
authors.affiliation: Waterland hospital, Purmerend.
authors.forename: Jan A C
authors.initials: JA
authors.lastname: Brakenhoff
authors.affiliation: Dept. of Internal Medicine, Spaarne hospital, Hoofddorp.
authors.forename: Jolanda G
authors.initials: JG
authors.lastname: Schrama
authors.affiliation: Dept. of Internal Medicine, Lievensberg Hospital, Bergen op Zoom, The Netherlands.
authors.forename: Fransje A A
authors.initials: FA
authors.lastname: Valster
authors.affiliation: Dept. of Internal Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.
authors.forename: Gerjo A
authors.initials: GA
authors.lastname: Velders
authors.affiliation: Dept. of Internal Medicine, St. Antonius Hospital, Nieuwegein.
authors.forename: Harry R
authors.initials: HR
authors.lastname: Koene
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D054796:Drug Dosage Calculations; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality / Q000473:pathology; D012008:Recurrence; D000069283:Rituximab; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab
keywords: early response; immune thrombocytopenia; open label phase II; rituximab; splenectomy delaying