title: Recurrent primary cardiac lymphoma on aortic valve allograft: implications for therapy.
abstract: Primary malignant cardiac lymphomas associated with grafts are extremely rare: to our knowledge, only 6 cases of prosthesis-associated B-cell lymphoma have been reported. Ours is the first report of recurrent diffuse large B-cell lymphoma associated with aortic valve allografts. We treated a 60-year-old man who presented in early 2007 with aortic valve endocarditis. He underwent aortic valve replacement with an allograft; the resected native valve showed active endocarditis without tumor. In January 2011, the patient underwent repeat aortic valve replacement because of symptomatic aortic regurgitation. The explanted valve specimen displayed diffuse large B-cell lymphoma. In September 2011, the patient presented with fever and a mass around the aortic valve. He died in January 2012. On autopsy, the explanted replacement valve displayed recurrent diffuse large B-cell lymphoma. The recurrent lymphoma on a new graft leads us to believe that this tumor is more aggressive than had been thought. We propose early systemic chemotherapy, in addition to tumor resection, for the possibility of a better prognosis. We discuss our patient's case and review the relevant medical literature.
authors.forename: Fahmi J
authors.initials: FJ
authors.lastname: Farah
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Chiles
mesh_terms: D064591:Allografts; D001021:Aortic Valve; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery
keywords: Aortic valve insufficiency/etiology/pathology; heart neoplasms/diagnosis/pathology/surgery; heart valve prosthesis/adverse effects; lymphoma, large B-cell, diffuse/diagnosis/pathology/surgery; recurrence; reoperation