title: Small cell lung cancer and progressive retinopathy.
abstract: Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis.
authors.affiliation: Department of Respiratory Medicine, Miyagi Cancer Center, Natori, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Morita
authors.affiliation: Department of Respiratory Medicine, Miyagi Cancer Center, Natori, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Fukuhara
authors.affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Respiratory Medicine, Miyagi Cancer Center, Natori, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Maemondo
mesh_terms: D001323:Autoantibodies / Q000097:blood; D051959:ELAV Proteins / Q000276:immunology; D004596:Electroretinography; D006801:Humans; D006867:Hydrolases; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis*; D012162:Retinal Degeneration / Q000150:complications* / Q000175:diagnosis*; D055752:Small Cell Lung Carcinoma / Q000150:complications*
chemical_list: D001323:Autoantibodies; D051959:ELAV Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases