title: Shared transcription factors contribute to distinct cell fates.
abstract: Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship between cell-type-specific binding patterns and gene expression. A recent study demonstrated how the same TFs can have functional roles when binding to largely non-overlapping genomic regions in hematopoietic progenitor and mast cells. Cell-type specific binding profiles of shared TFs are therefore not merely the consequence of opportunistic and functionally irrelevant binding to accessible chromatin, but instead have the potential to make meaningful contributions to cell-type specific transcriptional programs.
authors.affiliation: a Department of Haematology; Wellcome Trust and MRC Cambridge Stem Cell Institute & Cambridge Institute for Medical Research ; Cambridge University ; Cambridge , UK.
authors.forename: Felicia S L
authors.initials: FS
authors.lastname: Ng
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Calero-Nieto
authors.forename: Berthold
authors.initials: B
authors.lastname: Göttgens
mesh_terms: D000818:Animals; D019070:Cell Lineage; D015870:Gene Expression; D006801:Humans; D009928:Organ Specificity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
keywords: ChIP-seq, ChIP sequencing; GAM, generalized additive model; RNA-seq, RNA sequencing; TF, transcription factor; binding motif; hematopoiesis; mast cell; regression model