title: [Expression of bone morphogenetic protein 2 in lung adenocarcinoma with ossification].
abstract: We report a case of primary lung cancer with ossification. A 69-year-old woman was referred to our hospital due to an abnormal shadow on a chest roentgenogram. Chest computed tomography demonstrated an irregular mass with scattered high-density areas in the left lower lung. Excisional biopsy of the mass revealed lung adenocarcinoma, and we performed left lower lobectomy. Histologic examination revealed the tumor to be a papillary adenocarcinoma with ossification. We confirmed that bone morphogenetic protein(BMP)-2 developed from the tumor by a western blot analysis.
authors.affiliation: Department of Surgery, National Hospital Organization Asahikawa Medical Center, Asahikawa, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aoki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagase
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujiuchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Honmou
authors.forename: Kazunori
authors.initials: K
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maeda
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D009367:Neoplasm Staging; D009999:Ossification, Heterotopic / Q000209:etiology / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2