title: Outcome of transplantation in renal allograft recipients from cadaveric donors with standard and expanded criteria: a single-center experience.
abstract: BACKGROUND
  The increasing number of patients requiring kidney transplantation and the lack of available organs has led to the utilization of kidneys from expanded criteria donors (ECD).
  
  
  OBJECTIVE
  The comparison of the clinical outcome of renal transplantation, performed in a single center, between allograft recipients from standard (SCD) and expanded criteria donors (ECD).
  
  
  METHODS
  Data from 215 cadaveric renal transplantations performed during a 16 year period at the University Hospital of Patras were retrospectively studied. Donors' and recipients' characteristics (gender, age, history of hypertension and diabetes mellitus, cold ischemia time, post-transplant and long term graft function) were analyzed.
  
  
  RESULTS
  Grafts from donors with expanded criteria (ECD, n = 53) were allocated to older recipients whereas grafts from donors with standard criteria (SCD, n = 162) were allocated to younger recipients. The mean cold ischemia time was 1,146 min and was similar between the two groups of patients. Patients' survival rates were similar between allograft recipients from SCD and ECD up to the 5(th) post-transplant year of follow-up. Graft survival was significantly better in allograft recipients from SCD during a 5-year follow-up period. A significantly lower eGFR was noted in allograft recipients from ECD in comparison to those from SCD throughout the observation period. Cold ischemia time was positively correlated to the development of DGF, while patients with DGF had significantly worse graft function throughout the observation period.
  
  
  CONCLUSIONS
  Patient survival from ECD is comparable to that from SCD but graft survival is significantly lower. However, since renal function of recipients from ECD is adequate for long term period, grafts from ECD should be used in older patients.
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Papachristou
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Provatopoulou
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Savvidaki
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Kaplanis
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Kalliakmani
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Papasotiriou
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Fyssa
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tsamantas
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Fokaefs
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Marangos
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Mira
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Maroulis
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Karavias
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece. Electronic address: dgoumenos@upatras.gr.
authors.forename: D S
authors.initials: DS
authors.lastname: Goumenos
authors.affiliation: University Hospital of Patras, Transplantation Center, Patras, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Vlachogajannis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006115:Greece / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult