title: Sevoflurane-induced down-regulation of hippocampal oxytocin and arginine vasopressin impairs juvenile social behavioral abilities.
abstract: Cumulative evidence indicates that early childhood anesthesia can alter a child's future behavioral performance. Animal researchers have found that sevoflurane, the most commonly used anesthetic for children, can produce damage in the neonatal brains of rodents. To further investigate this phenomenon, we focused on the influence of sevoflurane anesthesia on the development of juvenile social behavioral abilities and the pro-social proteins oxytocin (OT) and arginine vasopressin (AVP) in the neonatal hippocampus. A single 6-h sevoflurane exposure for postnatal day 5 mice resulted in decreased OT and AVP messenger RNA (mRNA) and protein levels in the hippocampus. OT and AVP proteins became sparsely distributed in the dorsal hippocampus after the exposure to sevoflurane. Compared with the air-treated group, mice in the sevoflurane-treated group showed signs of impairment in social recognition memory formation and social discrimination ability. Sevoflurane anesthesia reduces OT and AVP activities in the neonatal hippocampus and impairs social recognition memory formation and social discrimination ability in juvenile mice.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan 2nd Road, Guangzhou, China, zhouzhibin1986@aliyun.com.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Zhou
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Bao-Long
authors.initials: BL
authors.lastname: Yuan
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Niu
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Huang
authors.forename: Xia
authors.initials: X
authors.lastname: Feng
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Zhou
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000235:genetics / Q000378:metabolism*; D004192:Discrimination, Psychological; D006624:Hippocampus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D008297:Male; D008568:Memory; D008738:Methyl Ethers / Q000009:adverse effects* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D010121:Oxytocin / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077149:Sevoflurane; D012919:Social Behavior
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D012333:RNA, Messenger; D001127:Arginine Vasopressin; D000077149:Sevoflurane; D010121:Oxytocin