title: Non-cell-adhesive substrates for printing of arrayed biomaterials.
abstract: Cellular microarrays have become extremely useful in expediting the investigation of large libraries of (bio)materials for both in vitro and in vivo biomedical applications. An exceedingly simple strategy is developed for the fabrication of non-cell-adhesive substrates supporting the immobilization of diverse (bio)material features, including both monomeric and polymeric adhesion molecules (e.g., RGD and polylysine), hydrogels, and polymers.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Appel
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Larson
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Luly
authors.forename: Jinseong D
authors.initials: JD
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011327:Printing / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D014867:Water; D011092:Polyethylene Glycols
keywords: biomedical applications; hydrogels; medical applications; polymeric materials; surface modification