title: Efficacy and safety of biapenem in treatment of infectious disease: a meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  Biapenem is a parenteral carbapenem antibiotic that has powerful antibacterial activity. The aim of this study is to evaluate the efficacy and safety of biapenem for the treatment of infection diseases.
  
  
  METHODS
  We performed a meta-analysis of published randomized-controlled trials (RCTs) identified in Embase, PubMed, and Cochrane library that compared the efficacy and safety of biapenem with other antibiotic regimes for the treatment of patients with infections.
  
  
  RESULTS
  Eight RCTs were included in the meta-analysis, involving totally 1685 patients with lower respiratory tract infections (LRTIs), complicated urinary tract infections (cUTIs), and complicated intra-abdominal infections (cIAIs). There was no difference found between the patients with LRTIs, cUTIs, or cIAIs treated with biapenem and comparators, regarding treatment success and adverse events.
  
  
  CONCLUSIONS
  This meta-analysis provides evidence that biapenem can be used as effectively and safely as imipenem-cilstatin or meropenem, for the treatment of patients with LRTIs, cUTIs, and cIAIs. It may be a considerable option for the treatment of these infections.
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Pei
authors.affiliation: b Department of Oncology , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Weijiao
authors.initials: W
authors.lastname: Yin
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Tongsheng
authors.initials: T
authors.lastname: Wang
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Mao
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Henan University of Science and Technology , Luoyang , PR China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012449:Safety; D013845:Thienamycins / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D013845:Thienamycins; C065257:biapenem
keywords: Biapenem; Infection; Meta-analysis