title: The role of human dendritic cells in HIV-1 infection.
abstract: Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
authors.affiliation: Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmed
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tatsuyoshi
authors.initials: T
authors.lastname: Kawamura
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimada
authors.affiliation: Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
authors.forename: Vincent
authors.initials: V
authors.lastname: Piguet
mesh_terms: D002450:Cell Communication / Q000502:physiology; D003713:Dendritic Cells / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology* / Q000517:prevention & control / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007801:Langerhans Cells / Q000502:physiology; D014765:Viral Vaccines / Q000627:therapeutic use
chemical_list: D014765:Viral Vaccines