title: Antiulcer activity of extracts of ecdysteroid-containing plants of genera Lychnis and Silene of the Caryophyllaceae family.
abstract: We studied antiulcer activity of the extracts of ecdysteroid-containing plants of the Caryophyllaceae family: Lychnis chalcedonica L., Silene viridiflora L.Sp.Pl., and Silene frivaldszkyana Hampe. Experiments on the model of neurogenic and aspirin-induced ulcerogenesis showed unidirectional and pronounced gastroprotective effects of S. viridiflora and L. chalcedonica extracts comparable to the efficacy of famotidine. In these models, a course of intragastric treatment with the extracts reduced ulcerative lesions of all types.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, krylova5935@gmail.com.
authors.forename: S G
authors.initials: SG
authors.lastname: Krylova
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
authors.forename: L N
authors.initials: LN
authors.lastname: Zibareva
authors.forename: E N
authors.initials: EN
authors.lastname: Amosova
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D026461:Ecdysteroids / Q000032:analysis*; D000431:Ethanol; D005260:Female; D031244:Lychnis / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D029751:Silene / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D018709:Statistics, Nonparametric; D013276:Stomach Ulcer / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D026461:Ecdysteroids; D010936:Plant Extracts; D000431:Ethanol