title: Molecular aspects of anti-atherosclerotic effects of short peptides.
abstract: We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: E V
authors.initials: EV
authors.lastname: Evlashkina
authors.forename: A O
authors.initials: AO
authors.lastname: Durnova
authors.forename: K L
authors.initials: KL
authors.lastname: Kozlov
authors.forename: O E
authors.initials: OE
authors.lastname: Gutop
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D058226:Plaque, Atherosclerotic / Q000378:metabolism; D017208:Rats, Wistar
chemical_list: D004151:Dipeptides; D047908:Intracellular Signaling Peptides and Proteins; D009842:Oligopeptides; C533570:lysyl-glutamyl-aspartic acid