title: Evaluation of perfusion-related and true diffusion in vertebral bone marrow: a preliminary study.
abstract: Our aim in this study was to obtain noninvasively more detailed information on perfusion and diffusion in vertebral bone marrow. We analyzed two diffusion components using a biexponential function. Eleven healthy volunteers were examined. By a 1.5-T MRI, we performed single-shot diffusion magnetic resonance imaging to acquire diffusion-weighted images (DWIs) with multiple b values. We determined perfusion-related diffusion and true diffusion coefficients (D* and D), the fraction of the perfusion-related diffusion component (F), and the apparent diffusion coefficient (ADC) in the lumbar vertebral body. Then, we compared these diffusion parameters with the bone mineral density (BMD) obtained with dual-energy X-ray absorptiometry. Moreover, the fat fraction (FF) of the bone marrow was calculated by use of double gradient-echo images with and without spectral adiabatic inversion recovery in the same subject. The BMD showed a significant positive correlation with D*, whereas there was no significant correlation between the other diffusion parameters and BMD. There was a negative correlation between the D or ADC and FF, although no correlation was found between D* or F and FF. Diffusion analysis with a biexponential function made it possible to obtain detailed information on bone perfusion and diffusion in healthy young volunteers.
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan, nohno@med.kanazawa-u.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohno
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Harumasa
authors.initials: H
authors.lastname: Kasai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Arai
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawano
authors.forename: Yuta
authors.initials: Y
authors.lastname: Shibamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gabata
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
mesh_terms: D000328:Adult; D015519:Bone Density; D001853:Bone Marrow / Q000033:anatomy & histology / Q000502:physiology*; D004058:Diffusion; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000033:anatomy & histology / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D055815:Young Adult