title: The T309G murine double minute 2 gene polymorphism is an independent prognostic factor for patients with renal cell carcinoma.
abstract: The purpose of this study was to evaluate the association of the T309G MDM2 gene polymorphism with renal cell carcinoma (RCC) risk, pathology, and cancer-specific survival (CSS). T309G MDM2 was genotyped in 449 Caucasians, including 240 with RCC and 209 cancer-free controls. The T309G MDM2 genotype was TT in 174 (38.8%), GT in 214 (47.7%), and GG in 61 (13.6%) subjects, without any significant differences between cases and controls on both univariable (p=0.58) and multivariable logistic regression (each p>0.25). Furthermore, T309G MDM2 was not linked with T stage (p=0.75), N stage (p=0.37), M stage (p=0.94), grade (p=0.21), and subtype (p=0.55). There was, however, a statistically significant association of T309G MDM2 with CSS (p=0.022): patients with TT had significantly worse survival than GG/GT (p=0.009), while those with GT and GG had similar outcomes (p=0.92). The 5-year survival rate for patients with TT, GT, and GG was 69.5%, 84.5%, and 89.7%, respectively. On the multivariable analysis, T309G was identified as an independent prognostic factor. The T309G MDM2 polymorphism is an independent prognostic factor for patients with RCC, with the TT genotype being associated with worse prognosis. In this study, there were no significant associations with RCC risk and pathology.
authors.affiliation: 1 Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna , Vienna, Austria .
authors.forename: Michela
authors.initials: M
authors.lastname: de Martino
authors.forename: Christopher
authors.initials: C
authors.lastname: Taus
authors.forename: Isabelle S
authors.initials: IS
authors.lastname: Wessely
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lucca
authors.forename: Sebastian L
authors.initials: SL
authors.lastname: Hofbauer
authors.forename: Andrea
authors.initials: A
authors.lastname: Haitel
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
authors.forename: Tobias
authors.initials: T
authors.lastname: Klatte
mesh_terms: D000368:Aged; D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2