title: Lipid peroxidation and mitochondrial superoxide dismutase-2 gene in adolescents with essential hypertension.
abstract: The study of LPO processes in adolescents of different races with essential hypertension revealed that Mongoloids exhibit oxidative stress by altering the level of the formation of diene conjugates, the primary LPO products. Caucasians increased the levels of both primary and end products of LPO, diene conjugates, and malondialdehyde. The revealed differences can be genetically determined because ethnic differences in the frequency of SOD2 gene Ala16Val polymorphism and its contribution to the biochemical phenotype were reported. The risk factors are Ala allele associated with increased MDA level for adolescent Caucasians and Val allele linked with decreased level of total antioxidant activity for adolescent Mongoloids.
authors.affiliation: Research Center of Family Health Problems and Human Reproduction, Siberian Division of Russian Academy of Medical Sciences, Irkutsk, Russia, tbairova@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Bairova
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.forename: O A
authors.initials: OA
authors.lastname: Pervushina
authors.forename: M A
authors.initials: MA
authors.lastname: Darenskaya
authors.forename: L A
authors.initials: LA
authors.lastname: Grebenkina
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology*; D018384:Oxidative Stress / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D044465:White People / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2