title: [Serum hydrogen sulfide levels in children with benign infantile convulsions associated with mild gastroenteritis].
abstract: OBJECTIVE
  To study the changes and significance of serum hydrogen sulfide (H2S) levels in children with benign infantile convulsions associated with mild gastroenteritis (BICE).
  
  
  METHODS
  Forty-two hospitalized children diagnosed with BICE were recruited to the observation group, and 46 children admitted due to acute gastroenteritis alone were recruited to the control group. Serum H2S levels were measured by a spectrophotometer.
  
  
  RESULTS
  The serum H2S level in the observation group was significantly lower than in the control group (28±12 μmol/L vs 45±10 μmol/L; P<0.01). The patients with a number of convulsions greater than or equal to two had significantly lower serum H2S levels than those with a number less than two (P<0.05). The number of convulsions was negatively correlated with serum H2S level in BICE patients (r=-0.485, P=0.001). When a convulsion exceeded 5 minues in duration, the duration was negatively correlated with serum H2S level (r=-0.736, P=0.004).
  
  
  CONCLUSIONS
  The reduction in endogenous H2S level might be one of the causes of convulsions in BICE patients. The degree of reduction in H2S level is associated with the number of convulsions and the duration of convulsion (when it exceeds 5 minues). Further investigation is needed to determine the clinical significance of these results.
authors.affiliation: Baoding Children's Hospital, Baoding, Hebei 071000, China. ydzhang666@163.com.
authors.forename: Yuan-Da
authors.initials: YD
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Gu
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Xie
authors.forename: Chao-Yu
authors.initials: CY
authors.lastname: Ji
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Pang
mesh_terms: D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000097:blood / Q000150:complications*; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D007223:Infant; D008297:Male; D012640:Seizures / Q000097:blood / Q000209:etiology*
chemical_list: D006862:Hydrogen Sulfide