title: Carcinoma of unknown primary in the inguinal lymph node region of squamous cell origin: A case series.
abstract: OBJECTIVE
  Cancer of unknown primary (CUP) of the inguinal region is a rare clinical entity that accounts for 1%-3 % of all CUPs. Of the inguinal lymph node region CUPs, about 10%-15% are of squamous cell origin. This study presents a case series of CUP of the inguinal region of squamous cell origin treated in our institution and review of the outcome.
  
  
  METHODS
  We have identified 9 patients treated during the period of 1990-2010. All patients were treated radically with chemoradiation. Regimens used were 5-fluorouracil (5-FU)/cisplatin combination (n = 8) or 5-FU/mitomycin-C (n = 1) regimen. Tumor doses were 5400 cGy (n = 7), 5500 cGy (n = 1), and 5040 cGy (n = 1).
  
  
  RESULTS
  The median duration of follow-up was 56 months (range, 10-76 months) for the whole group. There were no deaths or local or distant recurrences reported till the last recorded date of follow-up.
  
  
  CONCLUSIONS
  Our retrospective data showed significant long-term disease control for patients with localized inguinal region CUP of squamous cell origin who received concurrent chemoradiation.
authors.affiliation: Division of Radiation Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada. Electronic address: kurian.joseph@albertahealthservices.ca.
authors.forename: Kurian
authors.initials: K
authors.lastname: Joseph
authors.affiliation: Division of Medical Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Sawyer
authors.affiliation: Division of Radiation Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Amanie
authors.affiliation: University of Sint Eustatius School of Medicine, St. Maarten.
authors.forename: Joseph
authors.initials: J
authors.lastname: Jones Thachuthara
authors.affiliation: Division of Medical Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.
authors.forename: Sunita
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Allan Blair Cancer Centre, Regina, Saskatchewan, Canada.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tai
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007264:Inguinal Canal / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D012189:Retrospective Studies; D016896:Treatment Outcome