title: Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease.
abstract: OBJECTIVE
  The assessment of right ventricular (RV) perfusion defects has remained challenging during vasodilator stress perfusion with cardiovascular magnetic resonance (CMR). The significance of RV signal abnormalities during vasodilator stress perfusion and late gadolinium-enhanced CMR is yet uncertain.
  
  
  METHODS
  Among 61 individuals who underwent adenosine CMR stress testing before cardiac catheterization, we assessed the severity of coronary artery stenoses, mortality, the presence of stress and rest perfusion defects, as well as the presence of late gadolinium enhancement (LGE).
  
  
  RESULTS
  Right ventricular stress-induced perfusion defects were positively associated with left anterior descending artery and proximal right coronary artery stenoses but were negatively associated with left circumflex artery stenoses. The presence of RVLGE was associated with mortality, but 77% of those with RVLGE also had left ventricular LGE.
  
  
  CONCLUSIONS
  Proximal right coronary artery and left anterior descending artery stenoses are positively associated, whereas left circumflex artery stenoses are negatively associated with RV stress-induced perfusion defects. Right ventricular LGE was associated with mortality, but further study is needed to determine whether this is independent of left ventricular LGE.
authors.affiliation: From the *Department of Internal Medicine, and †Section of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC; ‡Division of Cardiology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS.
authors.forename: Michael Wesley
authors.initials: MW
authors.lastname: Milks
authors.forename: Bharathi
authors.initials: B
authors.lastname: Upadhya
authors.forename: Michael E
authors.initials: ME
authors.lastname: Hall
authors.forename: Sujethra
authors.initials: S
authors.lastname: Vasu
authors.forename: William Gregory
authors.initials: WG
authors.lastname: Hundley
authors.forename: Richard Brandon
authors.initials: RB
authors.lastname: Stacey
mesh_terms: D003287:Contrast Media; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation; D005080:Exercise Test; D005260:Female; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*
chemical_list: D003287:Contrast Media; D005682:Gadolinium