title: Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Medical Scientist Training Program and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Roundtree
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: 1] Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA [2] Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Sun
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: 1] Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA [2] Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.affiliation: Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D016601:RNA-Binding Proteins; C585900:YTHDF2 protein, human; D012313:RNA; C010223:N-methyladenosine; D000241:Adenosine