title: Isolated optic nerve, chiasm, and tract involvement in Bing-Neel Syndrome.
abstract: Central nervous system infiltration of Waldenström's macroglobulinemia is referred to as Bing-Neel Syndrome. We describe 2 patients whose clinical presentation was due to isolated involvement of the anterior visual pathways. The mechanism of visual failure in Bing-Neel Syndrome may involve both infiltrative and autoimmune processes.
authors.affiliation: Harvard University (MSH); University of Saskatchewan (EJA); Massachusetts Eye and Ear Infirmary (DMC, RCS); and Massachusetts General Hospital (FH), Boston, Massachusetts.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hughes
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Atkins
authors.forename: Dean M
authors.initials: DM
authors.lastname: Cestari
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Stacy
authors.forename: Fred
authors.initials: F
authors.lastname: Hochberg
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D008875:Middle Aged; D009897:Optic Chiasm / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D065866:Optic Tract / Q000473:pathology*; D014786:Vision Disorders / Q000209:etiology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000473:pathology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D008727:Methotrexate