title: Newcastle disease virus vaccine encapsulated in biodegradable nanoparticles for mucosal delivery of a human vaccine.
abstract: An overwhelming number of medicines on the market are oral medicine with the disadvantage of lower bioavailability universally. Newcastle disease (ND) has become a serious disease that threatens the poultry industries in many countries, and there are no treatments available for ND. The biodegradable materials could be surface modified and protect antigen or DNA from damage. Furthermore, nanoparticles are also a potential drug delivery with proper size. However, Newcastle disease virus (NDV) vaccines encapsulated in nanoparticles were widely used due to their proved a high safety and induced quicker and better mucosal and humoral immune responses. Here we review the results of mucosal immune delivery system for ND. Due to the safety, low toxicity, and better immunogenicity of the mucosal immune delivery system, our studies provide a clearly view that used the biodegradable materials to research and develop the human vaccines to save more patients' lives. These promising results provide a foundation for testing the approach in humans.
authors.affiliation: a Laboratory of Microbiology; College of Life Science; Heilongjiang University; Harbin, PR China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ci
authors.initials: C
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
mesh_terms: D058956:Administration, Mucosal; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D063566:Biodegradable Plastics; D002645:Chickens; D004337:Drug Carriers / Q000008:administration & dosage*; D007074:Immunoglobulin G / Q000097:blood; D053758:Nanoparticles / Q000008:administration & dosage*; D009521:Newcastle Disease / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D063566:Biodegradable Plastics; D004337:Drug Carriers; D007074:Immunoglobulin G; D014765:Viral Vaccines
keywords: L)-lactic-co-glycolic acid; Newcastle disease; Poly (D; chitosan; mucosal immunity delivery system; nanoparticles