title: Structure-odor relationships of semisynthetic β-santalol analogs.
abstract: A series of eleven β-santalol analogs, including nine new derivatives, was prepared by semisynthesis from natural (-)-(Z)-β-santalol and studied by gas chromatography-olfactometry (GC-O) to characterize their olfactory properties and potencies. These compounds and 45 others selected in the literature were used to build three olfactophores by molecular modelling. Three models were obtained that gather structural and physicochemical constraints that will be useful for further design of new sandalwood odorants.
authors.affiliation: Institute of Chemistry - Nice, University of Nice Sophia Antipolis, CNRS UMR 7272, Parc Valrose, FR-06108 Nice (phone: +33492076133; fax: +33492076125).
authors.forename: Céline
authors.initials: C
authors.lastname: Delasalle
authors.forename: Claire A
authors.initials: CA
authors.lastname: de March
authors.forename: Uwe J
authors.initials: UJ
authors.lastname: Meierhenrich
authors.forename: Hugues
authors.initials: H
authors.lastname: Brevard
authors.forename: Jérôme
authors.initials: J
authors.lastname: Golebiowski
authors.forename: Nicolas
authors.initials: N
authors.lastname: Baldovini
mesh_terms: D002849:Chromatography, Gas; D015394:Molecular Structure; D009812:Odorants; D064367:Olfactometry; D000081223:Polycyclic Sesquiterpenes; D032123:Santalum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C043206:santalol
keywords: Olfactometry; Sandalwood; Structureodor relationship (SOR); β-Santalol