title: Cicada-inspired cell-instructive nanopatterned arrays.
abstract: Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. A saving solution to this is seen in the ability of cells to uniquely respond to physical cues on such surfaces thus prompting the search for cell-instructive nanoscale patterns. Here we introduce a generic rationale engineered into biocompatible, titanium, substrates to differentiate cell responses. The rationale is inspired by cicada wing surfaces that display bactericidal nanopillar patterns. The surfaces engineered in this study are titania (TiO2) nanowire arrays that are selectively bactericidal against motile bacteria, while capable of guiding mammalian cell proliferation according to the type of the array. The concept holds promise for clinically relevant materials capable of differential physico-mechanical responses to cellular adhesion.
authors.affiliation: 1] National Physical Laboratory, Hampton Road, Teddington. TW11 0LW, UK [2] School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK.
authors.forename: Ting
authors.initials: T
authors.lastname: Diu
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington. TW11 0LW, UK.
authors.forename: Nilofar
authors.initials: N
authors.lastname: Faruqui
authors.affiliation: School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK.
authors.forename: Terje
authors.initials: T
authors.lastname: Sjöström
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington. TW11 0LW, UK.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Lamarre
authors.affiliation: School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK.
authors.forename: Howard F
authors.initials: HF
authors.lastname: Jenkinson
authors.affiliation: School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK.
authors.forename: Bo
authors.initials: B
authors.lastname: Su
authors.affiliation: 1] National Physical Laboratory, Hampton Road, Teddington. TW11 0LW, UK [2] School of Physics and Astronomy, University of Edinburgh, Edinburgh. UK EH9 3JZ, UK.
authors.forename: Maxim G
authors.initials: MG
authors.lastname: Ryadnov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006430:Hemiptera / Q000033:anatomy & histology; D006801:Humans; D053770:Nanowires; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D014921:Wings, Animal / Q000033:anatomy & histology
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; C009495:titanium dioxide; D014025:Titanium