title: Phytochemical and Pharmacological Investigation of Ethanol Extract of Cissampelos pareira.
abstract: In this study, the ethanol extract of Cissampelos pareira has been evaluated. The extract was tested for analgesic properties using both hot plate and acetic acid-induced writhing methods. Antiinflammatory effect was investigated using two different doses of 250 and 500 mg/kg body weight on Evans rats by carrageenan-induced paw edema test. The antipyretic activity was evaluated using Brewer's yeast-induced pyrexia in Wistar rats. The phytochemical screening of the extract of Cissampelos pareira exhibited the presence of several phytochemical compounds including saponins, gums and carbohydrates, reducing sugars, alkaloids and terpenoids. Ethanol extract of Cissampelos pareira exhibited significant analgesic, antiinflammatory and antipyretic activity in a dose-dependent manner. The results obtained from these studies confirm its therapeutic value against diseases caused by various pain and fever.
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: H M
authors.initials: HM
authors.lastname: Reza
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Shohel
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: Sadia B
authors.initials: SB
authors.lastname: Aziz
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: Farzana I
authors.initials: FI
authors.lastname: Pinaz
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: M F
authors.initials: MF
authors.lastname: Uddin
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Al-Amin
authors.affiliation: Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
authors.forename: I N
authors.initials: IN
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, North South University, Dhaka, Bangladesh.
authors.forename: Preeti
authors.initials: P
authors.lastname: Jain
keywords: Cissampelos pareira; analgesic; antiinflammatory; antioxidant; antipyretic; carrageenan-induced paw edema; yeast