title: Polymorphism of interleukin 6 -174 G/C in Behcet disease: case series and review of literature.
abstract: To assess the association between polymorphisms of the IL-6 -174 G/C and Behçet's disease (BD) in Tunisian patients. DNA was extracted from blood samples taken from 43 Tunisian patients and 43 healthy controls. The polymorphisms were analyzed by PCR with the PCR-RFLP. No significant association was found between patients and controls concerning polymorphism of IL6 -174 G/C between the (allelic frequency: C (17.44 vs 8, 13%; P=0.17) et G (82,55 vs 91,86%; P= 0.21). Neither age of onset of BD nor sex appears to be influenced by allelic variation of SNP-174 G / C of IL6. Disease duration of BD was longer in patients having the form 174 G-allele. SNP -174G/C was more frequent in patients without significant association (32.5 vs 16,26% ; P=0.07). SNP -174 G/C was not associated with the HLA B51. Neither age of onset of BD nor sex appears to be influenced by SNP-174 G / C of IL6. Disease duration of BD was longer in the absence of the SNP-174 G/C IL6, with no significant difference (79.2 + / -45.095 vs.70.28 + / - 47.034 months, P=0.59). The polymorphism of IL6 -174 G/C does not modulate clinical expression of BD. The single nucleotide polymorphisms of the IL-6 do not appear to be associated with BD reconstruction.
authors.affiliation: Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. hamzaoui.amira@yahoo.fr.
authors.forename: Amira
authors.initials: A
authors.lastname: Hamzaoui
authors.affiliation: Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. hamzaoui.amira@yahoo.fr.
authors.forename: Rim
authors.initials: R
authors.lastname: Klii
authors.affiliation: Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. hamzaoui.amira@yahoo.fr.
authors.forename: Olfa
authors.initials: O
authors.lastname: Harzallah
authors.affiliation: Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. hamzaoui.amira@yahoo.fr.
authors.forename: Touhami
authors.initials: T
authors.lastname: Mahjoub
authors.affiliation: Department of Genetic, University of Pharmacology, Monastir, Tunisia. hamzaoui.amira@yahoo.fr.
authors.forename: Silvia
authors.initials: S
authors.lastname: Mahjoub
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6