title: 6-Tosyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide analogues: synthesis, characterization, MO calculation, and antibacterial activity.
abstract: A series of 6-tosyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide analogues are synthesized by conventional techniques and characterized by elemental analysis, IR, MS, (1)H, and (13)C NMR. These are tested for their antibacterial activity against Bacillus subtilis (abbreviated as BS), Staphylococcus aureus (abbreviated as SA), and Escherichia coli (abbreviated as EC). The synthesized compounds are able to inhibit the growth of the SA and EC. None of the compounds are effective against BS. All valence molecular orbital (abbreviated as MO) calculations with PM6 have been carried out for the molecules for which bioactivity data are available. Ciprofloxacin is taken as the standard antibiotics to compare activity with the molecules synthesized. It has been attempted to correlate the activity of the molecules with their electronic structure.
authors.affiliation: Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), Sardar Patel University, NewV.V., Nagar, 388121, Gujarat, India, drhirendoshi@yahoo.co.in.
authors.forename: Hiren
authors.initials: H
authors.lastname: Doshi
authors.forename: Sampark
authors.initials: S
authors.lastname: Thakkar
authors.forename: Prashant
authors.initials: P
authors.lastname: Khirsariya
authors.forename: Mukund Chandra
authors.initials: MC
authors.lastname: Thakur
authors.forename: Arabinda
authors.initials: A
authors.lastname: Ray
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology; D004583:Electrons; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011725:Pyridines; D002939:Ciprofloxacin; C023666:pyridine