title: Antinociceptive effects of sinomenine in a rat model of neuropathic pain.
abstract: Sinomenine is a principal ingredient of traditional Chinese medicine, Sinomenium Acutum, which has been reported to have various pharmacological effects including anti-rheumatism and immunomodulation. This study examined the effects of sinomenine in rats that received chronic constriction injury (CCI), a model of peripheral neuropathic pain. CCI injury on the right sciatic nerve led to long-lasting mechanical hyperalgesia. Acute sinomenine treatment (10-40 mg/kg, i.p.) significantly and dose-dependently reversed mechanical hyperalgesia. In addition, the antinociceptive effects of sinomenine remained stable during repeated daily treatment for up to 2 weeks. Although sinomenine did not alter the duration of immobility in the forced swimming test in healthy animals, it dose-dependently reversed the increased immobility time in rats receiving CCI, suggesting that sinomenine attenuated chronic pain-induced depressive-like behavior. The antinociceptive effects of sinomenine were blocked by the GABAa receptor antagonist bicuculine. The doses of sinomenine studied here did not significantly alter the spontaneous locomotor activity. Together, these results suggested that sinomenine exerts significant antinociceptive effects for neuropathic pain via GABAa-mediated mechanism, which suggests that sinomenine may be useful for the management of chronic painful conditions such as neuropathic pain.
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Fang
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Jun-Xu
authors.initials: JX
authors.lastname: Li
mesh_terms: D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D009019:Morphinans / Q000008:administration & dosage*; D009437:Neuralgia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014110:Touch; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D009019:Morphinans; C009271:sinomenine