title: The single nucleotide polymorphism +936 C/T VEGF is associated with human epidermal growth factor receptor 2 expression in Moroccan breast cancer women.
abstract: The vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is involved in the development and progression of breast cancer (BC). The functional +936 C/T polymorphism of the VEGF-A gene has been implicated in BC susceptibility; however, published data are conflicting. In the current case-control study, we analyzed the association of the +936 C/T polymorphism with BC risk and tumor markers expression, human epidermal growth factor receptor 2 (HER2/neu) and caner antigen 15.3 (CA 15.3) in Moroccan women. We genotyped the DNA of 70 BC patients and 70 healthy women by TaqMan SNP assays. The χ(2) test and Fisher's exact test were used for statistical analyses. The overall results revealed that there is no association between the +936 C/T polymorphism and BC risk [p = 0.8; OR 0.87, 95 % CI (0.32-2.42)]. However, when we stratified the group of patients according to the status of tumor markers, a statistical significant association of +936 C/T SNP and HER2/neu expression was observed (p = 0.009). In contrast, no association with the other tumor marker, CA 15.3, was found (p = 0.090). Thus, the +936 C/T polymorphism seems to have a correlation with HER/neu expression in BC disease.
authors.affiliation: Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Av. Mohamed Belarbi El Alaoui, 6203, Rabat, Morocco, rahoui_jalila@yahoo.fr.
authors.forename: Jalila
authors.initials: J
authors.lastname: Rahoui
authors.forename: Yassir
authors.initials: Y
authors.lastname: Sbitti
authors.forename: Nadia
authors.initials: N
authors.lastname: Touil
authors.forename: Abdelilah
authors.initials: A
authors.lastname: Laraqui
authors.forename: Azeddine
authors.initials: A
authors.lastname: Ibrahimi
authors.forename: Brahim
authors.initials: B
authors.lastname: Rhrab
authors.forename: Abderrahman
authors.initials: A
authors.lastname: Al Bouzidi
authors.forename: Driss
authors.initials: D
authors.lastname: Moussaoui Rahali
authors.forename: Mohamed
authors.initials: M
authors.lastname: Dehayni
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ichou
authors.forename: Fatima
authors.initials: F
authors.lastname: Zaoui
authors.forename: Saad
authors.initials: S
authors.lastname: Mrani
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009018:Morocco; D018396:Mucin-1 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D012016:Reference Values; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; D014408:Biomarkers, Tumor; D018396:Mucin-1; D018719:Erb-b2 Receptor Tyrosine Kinases; D042461:Vascular Endothelial Growth Factor A; C467484:VEGFA protein, human; C508053:ERBB2 protein, human