title: Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review).
abstract: Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF‑1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc‑binding affinities of the zinc fingers of MTF‑1 and the α‑ and β‑domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF‑1 zinc finger number, and MTF‑1 containing certain zinc finger numbers regulates the expression of corresponding target genes. The present review evaluates the association between zinc finger number in MTF‑1 protein, MTF‑1 target genes and the mechanism underlying MT regulation of the zinc finger number in MTF‑1.
authors.affiliation: Department of Oral Medicine, Shandong Wanjie Medical College, Zibo, Shandong 255213, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Dong
authors.affiliation: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, Shandong 255213, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Cattle Research Department, Animal Husbandry Institute, Heilongjiang Academy of Agricultural Sciences, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Qi
authors.affiliation: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, Shandong 255213, P.R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Dou
authors.affiliation: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, Shandong 255213, P.R. China.
authors.forename: Qinglu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007477:Ions / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D018384:Oxidative Stress; D011485:Protein Binding; D020218:Response Elements; D014157:Transcription Factors / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*; D000097809:Transcription Factor MTF-1
chemical_list: D004268:DNA-Binding Proteins; D007477:Ions; D008668:Metallothionein; D014157:Transcription Factors; D015032:Zinc; D000097809:Transcription Factor MTF-1