title: Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines.
abstract: Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.
authors.affiliation: Facultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, Chile. alejandro.madrid@usm.cl.
authors.forename: Ivan
authors.initials: I
authors.lastname: Montenegro
authors.affiliation: Departamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, Chile. volgin_4@hotmail.com.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Tomasoni
authors.affiliation: Departamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, Chile. samybrs@hotmail.com.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bosio
authors.affiliation: Facultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, Chile. natuka_q@hotmail.com.
authors.forename: Natalia
authors.initials: N
authors.lastname: Quiñones
authors.affiliation: Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, Chile. alejandro.madrid@usm.cl.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Madrid
authors.affiliation: Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Carlos Antúnez 1920, Providencia, Santiago 7500000, Chile. hector.carrasco@uautonoma.cl.
authors.forename: Hector
authors.initials: H
authors.lastname: Carrasco
authors.affiliation: Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Carlos Antúnez 1920, Providencia, Santiago 7500000, Chile. andres.olea@uautonoma.cl.
authors.forename: Andres
authors.initials: A
authors.lastname: Olea
authors.affiliation: Departamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, Chile. rmartinez@unab.cl.
authors.forename: Rolando
authors.initials: R
authors.lastname: Martinez
authors.affiliation: Facultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, Chile. mauricio.cuellar@uv.cl.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cuellar
authors.affiliation: Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda N° 2664, Valparaíso 234000, Chile. juan.villena@uv.cl.
authors.forename: Joan
authors.initials: J
authors.lastname: Villena
mesh_terms: D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects; D005663:Furans / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D051336:Mitochondrial Membranes / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
chemical_list: D005663:Furans; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; D013764:Tetrahydronaphthalenes; C553567:confertifolin; C437376:drimane; C481244:drimenol; C034380:polygodial