title: Short communication: Emergence of novel A/G recombinant HIV-1 strains in Argentina.
abstract: The predominant circulating HIV-1 strains in South America are subtype B and B/F recombinants with different distributions among countries. However, the emergence of other subtypes is a matter of concern and needs continuous monitoring. We identified three different A/G recombinants in Argentina, two of them in vertically infected children from unlinked mothers and one in an adult female. HIV-1 pol sequences from the children showed novel A/G recombination patterns and no phylogenetic relationship with previously reported South American A/G sequences. The third A/G recombinant was a CRF06_cpx with African origin. The detection of new or unusual subtypes is important to avoid false-negative PCR HIV-1 early diagnosis due to detection failures and for future vaccine development.
authors.affiliation: 1 Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatría "Juan P. Garrahan"-CONICET , Buenos Aires, Argentina .
authors.forename: María F
authors.initials: MF
authors.lastname: Fernández
authors.forename: Marcelo D
authors.initials: MD
authors.lastname: Golemba
authors.forename: Carmen
authors.initials: C
authors.lastname: Terrones
authors.forename: Patricia
authors.initials: P
authors.lastname: Paradiso
authors.forename: Juan C
authors.initials: JC
authors.lastname: Nassif
authors.forename: Rosa
authors.initials: R
authors.lastname: Bologna
authors.forename: Andrea
authors.initials: A
authors.lastname: Mangano
authors.forename: Luisa
authors.initials: L
authors.lastname: Sen
authors.forename: Paula C
authors.initials: PC
authors.lastname: Aulicino
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D054302:pol Gene Products, Human Immunodeficiency Virus