title: Iron depletion with a novel apheresis system in patients with hemochromatosis.
abstract: BACKGROUND
  Phlebotomy represents the standard treatment option for iron overload in hemochromatosis (HC). Recently, red blood cell (RBC) apheresis has increasingly been used to remove iron. In this study we evaluated the depletion program of the newly developed Spectra Optia device.
  
  
  METHODS
  Adult male patients (n = 11) with HC were RBC depleted with the Spectra Optia device (Terumo BCT). In total, 24 procedures were performed. A volume of 300 to 550 mL of RBCs was withdrawn per single treatment.
  
  
  RESULTS
  No significant adverse events were recorded. A median blood volume of 857.3 ± 23.3 mL was processed. The median procedure time was 12.0 ± 0.4 minutes. The mean reduction of Hct value in each procedure was approximately 6% (Hct pre 42.6 ± 0.5% vs. Hct post 36.6 ± 0.6%) and iron removed per procedure was 405.2 ± 23.3 mg.
  
  
  CONCLUSIONS
  The Spectra Optia device proved to be highly efficient in depleting RBCs in HC patients and allows for short procedure time. The Optia device can be safely used in this clinical setting. We recommend its use in case of severe iron overload if rapid iron depletion needs to be achieved and in case of cardiac compromise due to less blood volume removed.
authors.affiliation: Blood Group Serology and Transfusion Medicine, Salzburg University Hospital (SALK), Salzburg, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Grabmer
authors.affiliation: Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
authors.forename: Doris
authors.initials: D
authors.lastname: Schmid
authors.affiliation: Blood Group Serology and Transfusion Medicine, Salzburg University Hospital (SALK), Salzburg, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Mayer
authors.affiliation: Internal Medicine I, Salzburg University Hospital (SALK), Salzburg, Austria.
authors.forename: Elmar
authors.initials: E
authors.lastname: Aigner
authors.affiliation: Internal Medicine I, Salzburg University Hospital (SALK), Salzburg, Austria.
authors.forename: Andrej
authors.initials: A
authors.lastname: Wagner
authors.affiliation: Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
authors.forename: Doris
authors.initials: D
authors.lastname: Streif
authors.affiliation: Blood Group Serology and Transfusion Medicine, Salzburg University Hospital (SALK), Salzburg, Austria.|Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Schallmoser
authors.affiliation: Blood Group Serology and Transfusion Medicine, Salzburg University Hospital (SALK), Salzburg, Austria.|Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
authors.forename: Eva
authors.initials: E
authors.lastname: Rohde
mesh_terms: D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D006432:Hemochromatosis / Q000097:blood* / Q000628:therapy*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male
chemical_list: D007501:Iron