title: Modified Beer-Lambert law for blood flow.
abstract: We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.
authors.affiliation: Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Wesley B
authors.initials: WB
authors.lastname: Baker
authors.affiliation: Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Ashwin B
authors.initials: AB
authors.lastname: Parthasarathy
authors.affiliation: Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA ; Div. of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Busch
authors.affiliation: Institute of Physics, University of Campinas, Campinas, SP 13083-859, Brazil.
authors.forename: Rickson C
authors.initials: RC
authors.lastname: Mesquita
authors.affiliation: Dept. Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
authors.affiliation: Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Yodh
keywords: (110.4153) Motion estimation and optical flow; (170.1470) Blood or tissue constituent monitoring; (170.1610) Clinical applications; (170.2655) Functional monitoring and imaging; (170.3660) Light propagation in tissues; (170.3880) Medical and biological imaging; (170.5270) Photon density waves; (170.6480) Spectroscopy, speckle; (170.6510) Spectroscopy, tissue diagnostics; (290.4210) Multiple scattering