title: Antioxidative effects of schidandrin B and green tea polyphenols against mercuric chloride-induced hepatotoxicity in rats.
abstract: In the present study, we investigated the hepatoprotective effects of schisandrin B (Sch B) and green tea polyphenols (GrTP), two natural antioxidants, against Hg hepatotoxicity. Fifty-six rats were randomly divided into four groups of fourteen animals in each group: control group, Hg-treated group, Sch B pretreated group, and GrTP pretreated group. HgCl2 injection increased Hg accumulation, pathological and ultrastructural injury, lactate dehydrogenase (LDH) level, alanine transaminase (ALT) level, apoptosis, reactive oxygen species (ROS) level, glutathione (GSH) level, and malondialdehyde (MDA) level. HgCl2 injection decreased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. Sch B and GrTP protected against Hg-induced dysfunction and liver injury by enhancing the antioxidant defense system. Our results indicate that Sch B and GrTP exert antioxidative effects against Hg-induced hepatotoxicity in rats.
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Yu
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Zhaofa
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Shu
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001.
authors.forename: Tianyao
authors.initials: T
authors.lastname: Yang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury; D034242:Cyclooctanes / Q000494:pharmacology; D017705:Lignans / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008627:Mercuric Chloride / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D011083:Polycyclic Compounds / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry
chemical_list: D000975:Antioxidants; D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; D059808:Polyphenols; D013662:Tea; C015499:schizandrin B; D008627:Mercuric Chloride