title: Association of the miR-149 Rs2292832 polymorphism with papillary thyroid cancer risk and clinicopathologic characteristics in a Chinese population.
abstract: (1) BACKGROUND: The genetic predisposition to papillary thyroid cancer (PTC) is far from clearly elucidated. Rs2292832 is a genetic polymorphism that located in the precursor of mir-149 and has been studied in diverse cancers. Thus far, the role of rs2292832 in PTC tumorigenesis and progression was unclear; (2) METHOD: Rs2292832 was genotyped in 838 PTCs, 495 patients with thyroid benign tumors (BNs) and 1006 controls in a Chinese Han population. Clinicopathological data was collected and compared. The expression level of mature mir-149 was examined in 55 normal thyroid tissue samples; (3) RESULTS: The CC genotype of rs2292832 was significantly associated with an increased risk of PTC compared with TT homozygote (OR = 1.60, 95% CI: 1.72-2.20, p = 0.003) and TT/TC combined genotype (OR = 1.54, 95% CI: 1.14-2.09, p = 0.005). Rs2292832 is an independent risk factor correlated with tumor invasion (p = 0.006) and higher T stage in PTC patients (p = 0.007), but uncorrelated with short-term disease persistence of PTC. PTC subjects carrying CC genotype have lower mir-149-5p expression than those with TC genotype (p = 0.002). Twelve predicted target genes have been identified by collaboratively using computational tools; (4) CONCLUSION: Rs2292832 was possibly involved in the susceptibility and local progression of PTC in Chinese patients, by altering the expression level of mir-149-5p and its target genes.
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. kakarwen@163.com.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wei
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. luzhongwu0301242@163.com.
authors.forename: Zhong-Wu
authors.initials: ZW
authors.lastname: Lu
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. liduanshu@shca.org.cn.
authors.forename: Duan-Shu
authors.initials: DS
authors.lastname: Li
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. wangyu@shca.org.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. zhuyongxue@shca.org.cn.
authors.forename: Yong-Xue
authors.initials: YX
authors.lastname: Zhu
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. wangzhuoyin@shca.org.cn.
authors.forename: Zhuo-Ying
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. wuyi@shca.org.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. headneck@126.com.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China. jq_hai@126.com.
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D002291:Carcinoma, Papillary; D002681:China / Q000453:epidemiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*
chemical_list: C551557:MIRN149 microRNA, human; D035683:MicroRNAs