title: Effects of atrazine on the oxidative damage of kidney in Wister rats.
abstract: The environmental persistence and bioaccumulation of herbicide atrazine may pose a significant threat to human health. In this experiment, 4 weeks old female Wister rats were treated by 0, 5, 25 and 125 mg/kg atrazine respectively for 28 days, and the oxidative stress responses as well as the activations of Nrf2 signaling pathway in kidney tissues induced by atrazine were observed. The results showed that after be treated by atrazine, the Blood urea nitrogen (BUN) and creatinine (CREA) levels in serum were increased, the contents of nitric oxide (NO) and malondialdehyde (MDA) in the kidney tissue homogenates were increased, the over-expressed Nrf2 transferred into the nuclei and played an antioxidant role by up-regulated the expression of II phase detoxifying enzymes such as heme oxygenase-1 (HO1) and NAD(P)H quinone oxidoreductase (NQO1) and the expression of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).
authors.affiliation: School of Environment, Northeast Normal University Changchun 130021, China ; Jilin Academic of Environmental Science Changchun 130021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, College of Basic Medical Sciences, Jilin University Changchun 130021, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Pathophysiology, College of Basic Medical Sciences, Jilin University Changchun 130021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, College of Basic Medical Sciences, Jilin University Changchun 130021, China.
authors.forename: Hebin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Jilin Academic of Environmental Science Changchun 130021, China.
authors.forename: Daguang
authors.initials: D
authors.lastname: Sun
authors.affiliation: Jilin Academic of Environmental Science Changchun 130021, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Liang
authors.affiliation: Department of Pathophysiology, College of Basic Medical Sciences, Jilin University Changchun 130021, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: School of Environment, Northeast Normal University Changchun 130021, China.
authors.forename: Jincheng
authors.initials: J
authors.lastname: Shang
keywords: Atrazine; Nrf2; kidney; oxidative injury; rat