title: Electroencephalographic Response to Different Odors in Healthy Individuals: A Promising Tool for Objective Assessment of Olfactory Disorders.
abstract: The aim of the present study was to examine human central nervous system response to three different odors. Electrophysiological activity was recorded in the baseline state and for 3 odors, lemon, peppermint, and vanilla, in 16 healthy participants. Electrodes were separated into groups according to the spatial position on the head. Fast Fourier transformation was performed on every set, and mean value of activity in theta was exported. As theta showed statistically significant results, further analysis was based only on the theta frequency band. On electrodes FP1, F3, Fz, F4, F8, T7, C3, Cz, C4, T8, TP9, CP5, CP1, CP2, CP6, P7, P3, Pz, P4, P8, PO9, and PO10 there was statistically significant difference in the electrical activity of the brain between four conditions. For peppermint and lemon, there was statistically significant difference in activity between different regions-F(1.576, 23.637)=16.030, P=.000 and F(1.362, 20.425)=4.54, P=.035, respectively-where the activity in the central area was significantly reduced compared with the activity in the other 4 areas and in the left and right anterior and left posterior area, respectively. There was no statistically significant difference for vanilla between specific areas, F(1.217, 18.257)=1.155, P=.309. The results indicate that olfactory stimuli can affect the frequency characteristics of the electrical activity of the brain.
authors.affiliation: Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krbot Skorić
authors.affiliation: Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Adamec
authors.affiliation: University of Zagreb, Zagreb, Croatia.
authors.forename: Ana Branka
authors.initials: AB
authors.lastname: Jerbić
authors.affiliation: Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Tereza
authors.initials: T
authors.lastname: Gabelić
authors.affiliation: Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Hajnšek
authors.affiliation: Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia School of Medicine, University of Zagreb, Zagreb, Croatia mhabek@mef.hr.
authors.forename: Mario
authors.initials: M
authors.lastname: Habek
mesh_terms: D000328:Adult; D004569:Electroencephalography; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009812:Odorants; D000857:Olfaction Disorders / Q000503:physiopathology*; D012903:Smell / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology
keywords: EEG response; odor; theta band