title: Emerging biomedical applications of nano-chitins and nano-chitosans obtained via advanced eco-friendly technologies from marine resources.
abstract: The present review article is intended to direct attention to the technological advances made in the 2010-2014 quinquennium for the isolation and manufacture of nanofibrillar chitin and chitosan. Otherwise called nanocrystals or whiskers, n-chitin and n-chitosan are obtained either by mechanical chitin disassembly and fibrillation optionally assisted by sonication, or by e-spinning of solutions of polysaccharides often accompanied by poly(ethylene oxide) or poly(caprolactone). The biomedical areas where n-chitin may find applications include hemostasis and wound healing, regeneration of tissues such as joints and bones, cell culture, antimicrobial agents, and dermal protection. The biomedical applications of n-chitosan include epithelial tissue regeneration, bone and dental tissue regeneration, as well as protection against bacteria, fungi and viruses. It has been found that the nano size enhances the performances of chitins and chitosans in all cases considered, with no exceptions. Biotechnological approaches will boost the applications of the said safe, eco-friendly and benign nanomaterials not only in these fields, but also for biosensors and in targeted drug delivery areas.
authors.affiliation: Faculty of Medicine, Department of Clinical & Molecular Sciences, Polytechnic University of Marche, IT-60100 Ancona, Italy. muzzarelli.raa@gmail.com.
authors.forename: Riccardo A A
authors.initials: RA
authors.lastname: Muzzarelli
authors.affiliation: Faculty of Engineering, Department of Industrial Engineering & Mathematical Sciences, Polytechnic University of Marche, IT-60100 Ancona, Italy. elmehtedi@univpm.it.
authors.forename: Mohamad
authors.initials: M
authors.lastname: El  Mehtedi
authors.affiliation: Faculty of Medicine, Department of Clinical & Molecular Sciences, Polytechnic University of Marche, IT-60100 Ancona, Italy. m.mattioli@univpm.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Mattioli-Belmonte
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism; D015374:Biosensing Techniques; D001709:Biotechnology / Q000379:methods; D002686:Chitin / Q000737:chemistry* / Q000302:isolation & purification; D048271:Chitosan / Q000737:chemistry* / Q000302:isolation & purification; D016503:Drug Delivery Systems; D006801:Humans; D057139:Nanofibers; D053758:Nanoparticles; D010316:Particle Size; D012038:Regeneration
chemical_list: D002686:Chitin; D048271:Chitosan