title: Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013.
abstract: Influenza A(H7N9) virus emerged in eastern China in February 2013 and continues to circulate in this region, but its ecology is poorly understood. In April 2013, the Guangdong Provincial Center for Disease Control and Prevention (CDC) implemented environmental and human syndromic surveillance for the virus. Environmental samples from poultry markets in 21 city CDCs (n=8,942) and respiratory samples from persons with influenza-like illness or pneumonia (n=32,342) were tested; viruses isolated from 6 environmental samples and 16 patients were sequenced. Sequence analysis showed co-circulation of 4 influenza A(H7N9) virus strains that evolved by reassortment with avian influenza A(H9N2) viruses circulating in this region. In addition, an increase in human cases starting in late 2013 coincided with an increase in influenza A H7 virus isolates detected by environmental surveillance. Co-circulation of multiple avian influenza viruses that can infect humans highlights the need for increased surveillance of poultry and potential environmental sources.
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Dawei
authors.initials: D
authors.lastname: Guan
authors.forename: Lirong
authors.initials: L
authors.lastname: Zou
authors.forename: Tie
authors.initials: T
authors.lastname: Song
authors.forename: Lina
authors.initials: L
authors.lastname: Yi
authors.forename: Xianqiao
authors.initials: X
authors.lastname: Zeng
authors.forename: Lijun
authors.initials: L
authors.lastname: Liang
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Ni
authors.forename: Min
authors.initials: M
authors.lastname: Kang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Haojie
authors.initials: H
authors.lastname: Zhong
authors.forename: Jianfeng
authors.initials: J
authors.lastname: He
authors.forename: Jinyan
authors.initials: J
authors.lastname: Lin
authors.forename: Derek
authors.initials: D
authors.lastname: Smith
authors.forename: David
authors.initials: D
authors.lastname: Burke
authors.forename: Ron A M
authors.initials: RA
authors.lastname: Fouchier
authors.forename: Marion
authors.initials: M
authors.lastname: Koopmans
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002681:China / Q000453:epidemiology; D004784:Environmental Monitoring; D005260:Female; D016679:Genome, Viral; D062306:Geography, Medical; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000145:classification / Q000235:genetics*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000235:genetics; D010802:Phylogeny; D058974:Phylogeography; D011200:Poultry / Q000821:virology*; D062486:Public Health Surveillance; D016865:Reassortant Viruses / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase