title: Dose-dependent effects of β-phenylglutamic acid hydrochloride (RGPU-135, neuroglutam) on animal behavior.
abstract: β-Phenylglutamic acid hydrochloride (RGPU-135, neuroglutam) in doses of 13-650 mg/kg suppressed depressive behavior of animals in the Porsolt test (i.e. produced antidepressant properties), reduced anxiety in the open-field, elevated plus maze, and Vogel conflict tests (i.e. produced anxiolytic effects). RGPU-135 in doses of 26-130 mg/kg exhibited more pronounced antidepressant action and in doses of 26 and 52 mg/kg had more pronounced anxiolytic effects. RGPU-135 in doses of 13-78 mg/kg increased locomotor and exploratory activity of animals in the open-field test. Activating effects of this agent decreased with increasing the dose. RGPU-135 in the subtoxic dose (650 mg/kg) suppressed locomotor activity of animals (produced sedative effect).
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: V V
authors.initials: VV
authors.lastname: Bagmetova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Chernyshova
authors.forename: O V
authors.initials: OV
authors.lastname: Merkushenkova
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects*; D018709:Statistics, Nonparametric
chemical_list: C581791:RGPU-135; D018698:Glutamic Acid