title: A functionalized fluorescent dendrimer as a pesticide nanocarrier: application in pest control.
abstract: We report the delivery of a hydrophobic pesticide, thiamethoxam, by water-soluble nanosized cationic dendrimers that contain hydrophobic dendritic polyesters and peripheral amines, demonstrated by DLS, spectral analysis and ITC. The dendrimer-based nanocarrier can efficiently deliver the pesticide into the live cells and largely increase the cytotoxicity of the drug.
authors.affiliation: Department of Entomology, China Agricultural University, 100193 Beijing, China. shenjie@cau.edu.cn.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.forename: Bicheng
authors.initials: B
authors.lastname: He
authors.forename: Zejun
authors.initials: Z
authors.lastname: Xu
authors.forename: Meizhen
authors.initials: M
authors.lastname: Yin
authors.forename: Wantai
authors.initials: W
authors.lastname: Yang
authors.forename: Huaijiang
authors.initials: H
authors.lastname: Zhang
authors.forename: Jingjun
authors.initials: J
authors.lastname: Cao
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D002151:Calorimetry; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007814:Larva / Q000187:drug effects; D007915:Lepidoptera / Q000187:drug effects / Q000254:growth & development; D008027:Light; D008099:Liver / Q000378:metabolism / Q000473:pathology; D049329:Nanostructures / Q000737:chemistry; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D010078:Oxazines / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D010575:Pesticides / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D011091:Polyesters / Q000737:chemistry; D012542:Scattering, Radiation; D000077922:Thiamethoxam; D013844:Thiazoles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity
chemical_list: D000588:Amines; D050091:Dendrimers; D004337:Drug Carriers; D000073943:Neonicotinoids; D009574:Nitro Compounds; D010078:Oxazines; D010575:Pesticides; D011091:Polyesters; D013844:Thiazoles; D000077922:Thiamethoxam