title: Antiviral activity of lambda-carrageenan prepared from red seaweed (Gigartina skottsbergii) against BoHV-1 and SuHV-1.
abstract: The antiviral effect of polysaccharides has been known for many years. Carrageenans are considered a good alternative for the prevention of a wide range of diseases, mainly caused by enveloped viruses. The advantages lie on their high availability, low cost and low induction of resistance. The aim of this study was to evaluate the sensitivity of two viral pathogens of veterinary interest to the presence of lambda-carrageenan. This is the first report of a lambda-carrageenan having antiviral activity against animal viruses belonging to the Alphaherpesvirinae subfamily, BoHV-1 (bovine herpesvirus type 1) strain Cooper and SuHV-1 (suid herpesvirus type 1) strain Bartha. Lambda-carrageenan was able to reduce infectivity of both viruses with a more pronounced effect against BoHV-1. These results proved, as previously shown for human herpes virus type 1, that these compounds could be used as potential antiviral agents in the veterinary field.
authors.affiliation: Área de Virología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Av. Chorroarín 280, Buenos Aires C1427CWO, Argentina.
authors.forename: Jésica V
authors.initials: JV
authors.lastname: Diogo
authors.affiliation: Área de Virología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Av. Chorroarín 280, Buenos Aires C1427CWO, Argentina.
authors.forename: Sabrina Galdo
authors.initials: SG
authors.lastname: Novo
authors.affiliation: Área de Virología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Av. Chorroarín 280, Buenos Aires C1427CWO, Argentina.
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: González
authors.affiliation: Cátedra de Química de Biomoléculas, Departamento de Biología Aplicada y Alimentos, Facultad de Agronomía, Universidad de Buenos Aires, Av. San Martín 4453, Buenos Aires C1417DSE, Argentina; National Research Council of Argentina (CIHIDECAR-CONICET), Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.
authors.forename: Marina
authors.initials: M
authors.lastname: Ciancia
authors.affiliation: Área de Virología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Av. Chorroarín 280, Buenos Aires C1427CWO, Argentina. Electronic address: abratanich@fvet.uba.ar.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Bratanich
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology*; D004285:Dogs; D007242:Herpesvirus 1, Bovine / Q000187:drug effects*; D011558:Herpesvirus 1, Suid / Q000187:drug effects*; D061985:Madin Darby Canine Kidney Cells; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D002351:Carrageenan
keywords: Antiviral; Herpesvirus; Lambda-carrageenan