title: Analysis of the selected biochemical blood parameters in patients after total hip replacement.
abstract: BACKGROUND
  The cause of osteoarthritis is inflammation associated with production of proinflammatory cytokines, activation of matrix metalloproteinases, dysregulation of extracellular matrix, and weakening of mechanical cartilage integration. The joint damage is mediated by reactive oxygen species. Biomarkers influencing the course of the disease can be found in the peripheral blood.
  
  
  OBJECTIVE
  The aim of the study was to confirm whether total hip replacement due to osteoarthritis changes the levels of biochemical parameters associated with degenerative changes.
  
  
  METHODS
  The study enrolled 34 patients qualified for total hip replacement. On the day of surgery, at day 10 after surgery and 6 weeks after surgery, blood was collected for analysis from the patients. Selected erythrocyte redox balance parameters were analyzed, i.e.: concentration of compounds reacting with thiobarbituric acid (TBARS), catalase activity, activity of superoxide dismutase and glutathione peroxidase and serum concentration of cytokines: IL6 and Il-1β/Il-1F2.
  
  
  CONCLUSIONS
  Hip joint alloplasty leads to a reduction of inflammatory parameters and shifts the redox balance toward a reduced state.
authors.forename: S Awomir
authors.initials: SA
authors.lastname: Goc
authors.forename: Monika
authors.initials: M
authors.lastname: Sienkiewicz
authors.affiliation: Department of Medical and Sanitary Microbiology, Medical University of Lodz, Poland, pl. Hallera 1, Lodz, 90-647, Poland..
authors.forename: Edward
authors.initials: E
authors.lastname: Kowalczyk