title: The primary cilium as sensor of fluid flow: new building blocks to the model. A review in the theme: cell signaling: proteins, pathways and mechanisms.
abstract: The primary cilium is an extraordinary organelle. For many years, it had the full attention of only a few dedicated scientists fascinated by its uniqueness. Unexpectedly, after decades of obscurity, it has moved very quickly into the limelight with the increasing evidence of its central role in the many genetic variations that lead to what are now known as ciliopathies. These studies implicated unique biological functions of the primary cilium, which are not completely straightforward. In parallel, and initially completely unrelated to the ciliopathies, the primary cilium was characterized functionally as an organelle that makes cells more susceptible to changes in fluid flow. Thus the primary cilium was suggested to function as a flow-sensing device. This characterization has been substantiated for many epithelial cell types over the years. Nevertheless, part of the central mechanism of signal transduction has not been explained, largely because of the substantial technical challenges of working with this delicate organelle. The current review considers the recent advances that allow us to fill some of the holes in the model of signal transduction in cilium-mediated responses to fluid flow and to pursue the physiological implications of this peculiar organelle.
authors.affiliation: Department of Biomedicine-Physiology, Aarhus University, Aarhus, Denmark hp@biomed.au.dk.
authors.forename: Helle A
authors.initials: HA
authors.lastname: Praetorius
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D008560:Membrane Fluidity / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008565:Membrane Proteins
keywords: ATP; calcium; flow; in vivo; primary cilia