title: Primary cutaneous T-cell lymphoma presenting as mycosis fungoides with a T-/null-cell phenotype: report of two cases.
abstract: Variations in the clinical and histological presentation of cutaneous T-cell lymphoma (CTCL) can hamper diagnosis. We report two cases of a novel presentation of CTCL characterized by an aberrant immunophenotype with complete loss of pan T-cell antigens including T-cell receptor β chain and showing the clinical and histopathological appearance of erythrodermic and plaque-stage mycosis fungoides.
authors.affiliation: Department of Dermatology, Hôpital Sud, University of Amiens, 80054, Amiens, France.
authors.forename: L
authors.initials: L
authors.lastname: Bekel
authors.affiliation: Department of Dermatology, Hôpital Sud, University of Amiens, 80054, Amiens, France.
authors.forename: G
authors.initials: G
authors.lastname: Chaby
authors.affiliation: Department of Dermatology, Hôpital Sud, University of Amiens, 80054, Amiens, France.
authors.forename: C
authors.initials: C
authors.lastname: Lok
authors.affiliation: Department of Dermatology, Hôpital Sud, University of Amiens, 80054, Amiens, France.
authors.forename: A
authors.initials: A
authors.lastname: Dadban
authors.affiliation: Department of Pathology, Hôpital Nord, University of Amiens, 80054, Amiens, France.
authors.forename: D
authors.initials: D
authors.lastname: Chatelain
authors.affiliation: Department of Dermatology, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Henri Mondor, UPEC University, 94010, Créteil, France.
authors.forename: S
authors.initials: S
authors.lastname: Ingen-Housz-Oro
authors.affiliation: Department of Pathology, INSERM U955 Equipe 9, AP-HP, Groupe Hospitalier Henri Mondor, UPEC University, 94010, Créteil, France.
authors.forename: N
authors.initials: N
authors.lastname: Ortonne
mesh_terms: D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000276:immunology; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016693:Receptors, Antigen, T-Cell, alpha-beta