title: Physiological functions of presenilins; beyond γ-secretase.
abstract: Presenilin (PS) was identified in screens for mutations causing the early onset forms of familial Alzheimer's disease (FAD) in 1995. As catalytic units of the γ-secretase complex, presenilins participate in the processing of amyloid beta protein (Aβ), the main component of deposits in brain of patients with AD. The more than 90 substrates of γ-secretase isolated so far demonstrate its contribution to wide range of cellular processes and signaling events. However, recent findings have revealed numerous γ-secretase-independent presenilin functions, including involvement in calcium homeostasis, endoplasmic reticulum (ER) stress and autophagy. This mini-review attempts to summarize the multiple physiological and pathological functions of presenilin.
authors.forename: Ibolya
authors.initials: I
authors.lastname: Stiller
authors.forename: Beáta
authors.initials: B
authors.lastname: Lizák
authors.affiliation: 1444 Budapest, POB 260, Hungary. banhegyi@eok.sote.hu.
authors.forename: Gábor
authors.initials: G
authors.lastname: Bánhegyi
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001343:Autophagy; D020013:Calcium Signaling / Q000502:physiology; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D053763:Presenilins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D058767:Protein Unfolding; D013379:Substrate Specificity
chemical_list: D016229:Amyloid beta-Peptides; D053763:Presenilins; D053829:Amyloid Precursor Protein Secretases