title: Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug.
abstract: A novel, fast, and easy mechano-chemistry-based (dry milling) method has been developed to exfoliate graphene with hydrophobic drugs generating few-layer graphene mesosheets (< 10 nm in thickness and ∼1 μm in width). The electronic properties of the graphitic structure were partially preserved after the milling treatment compared with graphene oxide prepared by Hummers' method. Several characterization techniques such as thermogravimetric analysis, Raman spectroscopy, atomic force microscopy, electron microscopy, and molecular dynamics simulation were used to characterize this material. The drug-exfoliated mesosheets were pharmacologically inactive, offering a new approach for making water-soluble few-layer graphene mesosheets upon dry milling with hydrophobic drugs, mainly used as exfoliating agents.
authors.affiliation: Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.
authors.forename: Noelia
authors.initials: N
authors.lastname: Rubio
authors.forename: Rui
authors.initials: R
authors.lastname: Serra-Maia
authors.forename: Houmam
authors.initials: H
authors.lastname: Kafa
authors.forename: Kuo-Ching
authors.initials: KC
authors.lastname: Mei
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Pach
authors.forename: William
authors.initials: W
authors.lastname: Luckhurst
authors.forename: Mire
authors.initials: M
authors.lastname: Zloh
authors.forename: Frederic
authors.initials: F
authors.lastname: Festy
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Richardson
authors.forename: Julian R
authors.initials: JR
authors.lastname: Naglik
authors.forename: Belén
authors.initials: B
authors.lastname: Ballesteros
authors.forename: Khuloud T
authors.initials: KT
authors.lastname: Al-Jamal
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D018625:Microscopy, Atomic Force; D056004:Molecular Dynamics Simulation; D012995:Solubility; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D014867:Water; D006108:Graphite; D000666:Amphotericin B