title: Wall motion changes in myocardial infarction in relation to the time elapsed from symptoms until revascularization.
abstract: OBJECTIVE
  Wall motion abnormalities during acute ST-segment elevation myocardial infarction (STEMI) and the improvement after recanalization depend on the conditions of the coronary occlusion.
  
  
  METHODS
  Fifty-seven patients with first-ever STEMI due to one-artery occlusion, treated with primary PCI, were evaluated. Area at risk and left ventricular wall motion abnormalities were localized with coronary angiography and echocardiography and then compared in relation to the time elapsed from the onset of symptoms at the time of infarction and at 3 months. Left ventricular diameters and ejection fractions were evaluated in relation to the ischemic time.
  
  
  RESULTS
  Three hundred forty-one affected left ventricular segments were detected with angiography, while echocardiography showed 206 segments with motion abnormality. No correlation was found between the regional wall motion index in the area at risk and the time elapsed from the beginning of symptoms. However, the improvement in wall motion abnormalities at the follow-up was dependent on the ischemic time (r=-0.29, p<0.03). The early subgroup showed significant improvement in left ventricular ejection fraction at follow-up (p=0.03), whereas in the late subgroup, a significant increase in left ventricle diameters was observed.
  
  
  CONCLUSIONS
  Our results first demonstrate in humans that in the early hours from the occlusion of the coronary artery, the extent and severity of the wall motion abnormalities inside the area at risk show large variability without relation to the elapsed time since the onset of symptoms. On the other hand, the results of follow-up echocardiography proved that the wall motion improvement was highly dependent on the ischemic time.
authors.affiliation: Institute of Cardiology and Heart Surgery, University of Debrecen Clinical Center; Debrecen-Hungary. iracz73@gmail.com.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Rácz
authors.forename: László
authors.initials: L
authors.lastname: Fülöp
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kolozsvári
authors.forename: Gábor T
authors.initials: GT
authors.lastname: Szabó
authors.forename: Annamária
authors.initials: A
authors.lastname: Bódi
authors.forename: Andrea
authors.initials: A
authors.lastname: Péter
authors.forename: Attila
authors.initials: A
authors.lastname: Kertész
authors.forename: Ida
authors.initials: I
authors.lastname: Hegedüs
authors.forename: István
authors.initials: I
authors.lastname: Édes
authors.forename: László
authors.initials: L
authors.lastname: Balkay
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Köszegi
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*