title: Comparison between propofol and dexmedetomidine on depth of anesthesia: A prospective randomized trial.
abstract: OBJECTIVE
  Intravenous agents such as propofol are commonly used to maintain adequate depth of anesthesia. Dexmedetomidine which has an anesthetic sparing effect is being considered for maintaining intraoperative depth of anesthesia. We hypothesized to compare the effect of dexmedetomidine on depth of anesthesia with propofol and evaluated whether dexmedetomidine can be used as sole anesthetic agent in maintaining depth of anesthesia.
  
  
  METHODS
  Sixty patients of ASA PS I, 18-65 years of age, scheduled for laparotomy under general anesthesia were randomly divided into two groups of 30 each. Group A received propofol 1 mg/kg bolus followed by infusion (50 mcg/kg/min) and Group B received dexmedetomidine 1 mcg/kg bolus followed by infusion (0.5 mcg/kg/h). Both the groups were administered standard general anesthesia with routine monitoring along with Bispectral index (BIS) and values were recorded at intervals of 10 min. In all patients Ramsay sedation score was recorded after extubation and they were assessed for recall of intraoperative events using Modified Brice questionnaire.
  
  
  RESULTS
  Heart rate and mean arterial pressure were less in Group B than Group A. Intraoperative BIS values were significantly lower in Group B (P < 0.0001). Although sedation score was more in Group B it did not prolong recovery. No recall was found in any patient.
  
  
  CONCLUSIONS
  Dexmedetomidine was comparable with propofol in maintaining anesthesia and it can produce better control of hemodynamics and BIS value. Thus dexmedetomidine can be used as the sole maintenance anesthetic agent.
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Uddalak
authors.initials: U
authors.lastname: Chattopadhyay
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Suchismita
authors.initials: S
authors.lastname: Mallik
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Sarmila
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Susmita
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Subrata
authors.initials: S
authors.lastname: Bisai
authors.affiliation: Department of Anesthesiology, Burdwan Medical College, Burdwan, West Bengal, India.
authors.forename: Hirak
authors.initials: H
authors.lastname: Biswas
keywords: BIS; Bispectral index; dexmedetomidine; propofol; recall; sedation score