title: Pacing site in pacemaker dependency: is right ventricular septal lead position the answer?
abstract: The right ventricular apex has been the traditional site for lead placement in patients with atrioventricular block. Pacing at the right ventricular apex may have long-term deleterious effects on left ventricular (LV) function, promoting heart failure and increasing mortality. Pacing at the right ventricular septum has been proposed to minimize deterioration in LV function. Although experimental data suggest that septal pacing protects LV function, clinical studies have provided conflicting results. A recent large study in patients with heart block did not show a protective effect with septal pacing. Other pacing approaches are becoming increasingly relevant; however, prediction of what method should be employed in which patient is not currently possible. Other factors such as baseline LV function and associated co-morbidities impact LV function, irrespective of pacing site. Continued monitoring of cardiac function post-implant is therefore critical to ongoing care. An algorithm for managing patients with atrioventricular block is proposed.
authors.affiliation: Department of Cardiology, Princess Alexandra Hospital, Woolloongabba and University of Queensland, Brisbane 4102, Australia.
authors.forename: Gerry
authors.initials: G
authors.lastname: Kaye
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods; D006333:Heart Failure / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D010138:Pacemaker, Artificial; D016277:Ventricular Function, Left / Q000502:physiology*; D054088:Ventricular Septum / Q000503:physiopathology*
keywords: alternate site pacing; atrioventricular block; cardiac resynchronization therapy; heart failure; left ventricular function; right ventricular apical pacing; right ventricular septal pacing