title: TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance.
abstract: Multi-drug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively investigated for overcoming MDR in cancer therapy because of its ability to inhibit P-glycoprotein (P-gp). In this work, TPGS was for the first time used as a new surface modifier to functionalize NaYbF4:Er upconversion nanoparticles (UNCPs) and endowed the as-prepared products (TPGS-UCNPs) with excellent water-solubility, P-gp inhibition capability and imaging-guided drug delivery property. After the chemotherapeutic drug (doxorubicin, DOX) loading, the as-formed composites (TPGS-UCNPs-DOX) exhibited potent killing ability for DOX-resistant MCF-7 cells. Flow-cytometric assessment and Western blot assay showed that the TPGS-UCNPs could potently decrease the P-gp expression and facilitate the intracellular drug accumulation, thus achieving MDR reversal. Moreover, considering that UCNPs process efficient upconversion emission and Yb element contained in UCNPs has strong X-ray attenuation ability, the as-obtained composite could also serve as a dual-modal probe for upconversion luminescence (UCL) imaging and X-ray computed tomography (CT) imaging, making them promising for imaging-guided cancer therapy.
authors.affiliation: College of Chemistry, Sichuan University, Chengdu, 610064, PR China; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Gan
authors.initials: G
authors.lastname: Tian
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China; College of Materials Science and Opto-electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, PR China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430030, PR China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430030, PR China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address: zjgu@ihep.ac.cn.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
authors.affiliation: College of Chemistry, Sichuan University, Chengdu, 610064, PR China; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, PR China; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, PR China. Electronic address: zhaoyuliang@ihep.ac.cn.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D005453:Fluorescence; D006801:Humans; D049449:Luminescence; D061986:MCF-7 Cells; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D019301:Oleic Acid / Q000737:chemistry; D011092:Polyethylene Glycols / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014057:Tomography, X-Ray Computed; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000970:Antineoplastic Agents; D014810:Vitamin E; D019301:Oleic Acid; D011092:Polyethylene Glycols; D015018:Ytterbium; C014225:tocophersolan
keywords: Multi-drug resistance; P-gp inhibition; TPGS; Theranostics; Upconversion nanoparticles