title: [Influence of long-term adaptation to cold on the state of cardiovascular system].
abstract: The inhabitancy in Far North increases a probability of development of coronary heart disease, acute myocardial infarction and arterial hypertension. Catecholamines and NO deficiency play a substantial role in the development of cold hypertension, but these are not involved in acclimatization cardiac hypertrophy. Data of in vivo experiments indicate in favor of an involvement of α-adrenergic receptors (ARs) in the mechanism of an appearance of cold hypertension. Cold acclimatization promotes an elevation of β3-AR density and decrease in β1-AR and β2-AR quantity on sarcolemma of cardiomyocytes. Experimental data indicate the important role of aldosterone and angiotensin II in the development of acclimatization hypertension. Catecholamines, aldosterone and angiotensin II are not involved in cold hypertrophy of heart. Experimental data demonstrate the important role of endothelin ETA receptor in the formation of cold hypertrophy of heart and cardiofibrosis. Thyroid hormones play substantial role in the development of cold hypertension and cardiac hypertrophy.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: E A
authors.initials: EA
authors.lastname: Vychuzhanova
mesh_terms: D000064:Acclimatization; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002395:Catecholamines / Q000378:metabolism; D003080:Cold Temperature; D006728:Hormones / Q000378:metabolism; D006801:Humans; D011941:Receptors, Adrenergic / Q000378:metabolism; D017466:Receptors, Endothelin / Q000378:metabolism
chemical_list: D002395:Catecholamines; D006728:Hormones; D011941:Receptors, Adrenergic; D017466:Receptors, Endothelin