title: [Parametrial involvement in cervical cancer IB1 patients treated with radical hysterectomy in Peru].
abstract: OBJECTIVE
  To assess the frequency and factors associated with parametrial involvement (PI) in patients with cervical cancer IB1 who underwent radical hysterectomy (RH) at the National Institute of Neoplastic Diseases in Peru.
  
  
  METHODS
  Cross-sectional study of 214 patients with cervical cancer IB1 undergoing RH with pelvic lymphadenectomy between 2007 and 2012. The population was compared with and without clinicopathological variables associated with PI such as age, tumor size, depth of infi histological grade and pelvic lymph node involvement.
  
  
  RESULTS
  Ten patients (4.6%) had PI. Multivariate analysis showed that the depth of invasion (OR 8.37, 95% CI 1.24- 56.41, p=0.029) and pelvic node involvement (OR 18.03; 95% CI 3.30-98.44, p=0.001) were all independent predictors of PI. The presence of tumor size = 2 cm, invasion = 10 mm, absence of lymphovascular permeation and absence of nodal involvement identifi 97 patients at low risk of PI, none of whom had PI pathology.
  
  
  CONCLUSIONS
  We confi the low frequency of PI in the cervical cancer IB1 subgroup and its association with the depth of invasion and lymph node involvement suggested in previous studies. This information will allow the identifi of a subgroup of patients at low risk of PI for less radical surgery in our institution.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Urrutia
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Santos
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Albert
authors.initials: A
authors.lastname: Zevallos
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Aldo
authors.initials: A
authors.lastname: López
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Absalón
authors.initials: A
authors.lastname: Montoya
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Marco
authors.initials: M
authors.lastname: Sánchez
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Henry
authors.initials: H
authors.lastname: Valdivia
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Velarde
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Raúl
authors.initials: R
authors.lastname: Mantilla
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Milla
authors.initials: M
authors.lastname: Esperanza
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Castañeda
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Mayer
authors.initials: M
authors.lastname: Zaharia
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Manuel
authors.initials: M
authors.lastname: Álvarez
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D017773:Pelvic Floor; D010568:Peru; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*; D055815:Young Adult