title: Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group.
abstract: A concise total synthesis of the plant alkaloid (±)-leuconolam (1) has been achieved. A regio- and diastereoselective Lewis-acid mediated allylative cyclization was used to establish, simultaneously, two adjacent tetrasubstituted carbon centers. Furthermore, an essential arene cross-coupling to a hindered haloalkene was enabled by the use of a novel 2-anilinostannane.
authors.affiliation: Department of Chemistry, 207 Pleasant St. SE, University of Minnesota, Minneapolis, MN 55455, USA Tel: 612-625-1891.
authors.forename: Enver Cagri
authors.initials: EC
authors.lastname: Izgu
authors.affiliation: Department of Chemistry, 207 Pleasant St. SE, University of Minnesota, Minneapolis, MN 55455, USA Tel: 612-625-1891.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hoye