title: Remote meta-C-H olefination of phenylacetic acids directed by a versatile U-shaped template.
abstract: meta-C-H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile-containing template. The identification of N-formyl-protected glycine as the ligand (Formyl-Gly-OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Youqian
authors.initials: Y
authors.lastname: Deng
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
keywords: CH activation; olefination; palladium; phenylacetic acid; template synthesis