title: Towards an expert system for accurate diagnosis and progress monitoring of Parkinson's disease.
abstract: While Parkinson's disease is a chronic and progressive movement disorder, no one can predict which symptoms will affect an individual patient. At the present time there is no cure for Parkinson's disease but instead a variety of alternative treatments provide relief from the symptoms. Due to these unpromising factors, we propose a new multi-scale ontology-based modeling technology for the accurate diagnosis of Parkinson's disease and its progress monitoring. The proposed model will be used to assess the status of the patient with PD corresponding treatments using a multilayer neural network. The proposed tool also aims to identify new associated physical and biological biomarkers from heterogeneous patients' data. The architecture of this expert system and its implementation in Protégé is presented in this paper.
authors.affiliation: BiHELab, Department of Informatics, Ionian University, Plateia Tsirigoti 7, 49100, Corfu, Greece, alexiou@ionio.gr.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Alexiou
authors.forename: Maria
authors.initials: M
authors.lastname: Psiha
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Vlamos
mesh_terms: D000465:Algorithms; D000978:Antiparkinson Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D002230:Carbidopa / Q000627:therapeutic use; D046690:Deep Brain Stimulation / Q000379:methods; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005103:Expert Systems; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D012680:Sensitivity and Specificity
chemical_list: D000978:Antiparkinson Agents; D015415:Biomarkers; D007980:Levodopa; D002230:Carbidopa