title: Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society.
abstract: BACKGROUND
  Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.
  
  
  METHODS
  The relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.
  
  
  RESULTS
  Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age ≥80 years).
  
  
  CONCLUSIONS
  Our analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI.
authors.affiliation: Cardiovascular Research Group, Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Chun Shing
authors.initials: CS
authors.lastname: Kwok
authors.forename: Simon G
authors.initials: SG
authors.lastname: Anderson
authors.forename: Katherine S L
authors.initials: KS
authors.lastname: McAllister
authors.forename: Matthew
authors.initials: M
authors.lastname: Sperrin
authors.forename: Peter D
authors.initials: PD
authors.lastname: O'Kane
authors.forename: Bernard
authors.initials: B
authors.lastname: Keavney
authors.forename: James
authors.initials: J
authors.lastname: Nolan
authors.forename: Phyo Kyaw
authors.initials: PK
authors.lastname: Myint
authors.forename: Azfar
authors.initials: A
authors.lastname: Zaman
authors.forename: Iain
authors.initials: I
authors.lastname: Buchan
authors.forename: Peter F
authors.initials: PF
authors.lastname: Ludman
authors.forename: Mark A
authors.initials: MA
authors.lastname: de Belder
authors.forename: Mamas A
authors.initials: MA
authors.lastname: Mamas
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012955:Societies, Medical; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
keywords: PCI; age; left ventricular function