title: Poly(2-oxazoline)-based nanogels as biocompatible pseudopolypeptide nanoparticles.
abstract: Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 μg/mL) and that no specific interaction with bovine serum albumin was observed.
authors.affiliation: Université de Bordeaux , UMR5629, ENSCPB, 16 Avenue Pey Berland, 33607 Pessac Cedex, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Legros
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Wirotius
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.forename: Kam Chiu
authors.initials: KC
authors.lastname: Tam
authors.forename: Daniel
authors.initials: D
authors.lastname: Taton
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lecommandoux
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D002460:Cell Line; D051379:Mice; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D010080:Oxazoles / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000378:metabolism; D011094:Polyethyleneimine / Q000737:chemistry* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D000080385:Nanogels; D010080:Oxazoles; C577913:poly(2-oxazoline); C413692:polyethylene glycol polyethyleneimine nanogel; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D011094:Polyethyleneimine