title: CNS metastases in breast cancer patients: prognostic implications of tumor subtype.
abstract: Development of brain metastases (BM) in breast cancer leads to limited survival. The therapeutical options are limited. There are less data about the risk factors and prognostic importance in BM. Objective is to investigate predictors of central nervous system metastases and outcome after diagnosis of BM according to tumor subtype. Based on medical records, 80 consecutive patients with primary non-metastatic operable breast cancer, treated at Department of Gynecology, University of Tübingen, and who developed BM during follow-up, were retrospectively analyzed. Clinicopathological parameters and their prognostic impact were evaluated. A node involvement (40 %), ER/PR negative (53.75 vs. 61.25 %), triple negative (28.75 %) and HER2+ status (40 %) were associated with BM. BM in breast cancer patients lead to a shortened survival. In cerebral metastatic breast cancer patients with HER2-negative and triple-negative, patients had significant shorter survival after detection of BM compared with HER2-positive and non-triple-negative patients (p = 0.001; p = 0.03). Risk of BM varies significantly by subtype. Understanding the biology of metastases can help categorize patients into prognostically useful categories and tailor treatment regimens for individual patients. Prospective clinical trials would be required for evaluating the potential role of screening for asymptomatic BM and of treatment of triple-negative patients.
authors.affiliation: Department of Gynecology, University of Tübingen, Calwer Str. 7, 72070, Tübingen, Germany, cornelia.bachmann@med.uni-tuebingen.de.
authors.forename: C
authors.initials: C
authors.lastname: Bachmann
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: A
authors.initials: A
authors.lastname: Staebler
authors.forename: T
authors.initials: T
authors.lastname: Fehm
authors.forename: F
authors.initials: F
authors.lastname: Fend
authors.forename: J
authors.initials: J
authors.lastname: Schittenhelm
authors.forename: D
authors.initials: D
authors.lastname: Wallwiener
authors.forename: E
authors.initials: E
authors.lastname: Grischke
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000401:mortality / Q000556:secondary*; D016543:Central Nervous System Neoplasms / Q000401:mortality / Q000556:secondary*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor