title: SEURAT: Safety Evaluation Ultimately Replacing Animal Testing--recommendations for future research in the field of predictive toxicology.
abstract: The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained in SEURAT-1 and appreciating international advancement in both basic and regulatory science, we reflect here on how SEURAT should evolve and propose that further research and development should be directed along two complementary and interconnecting work streams. The first work stream would focus on developing new 'paradigm' approaches for regulatory science. The goal here is the identification of 'critical biological targets' relevant for toxicity and to test their suitability to be used as anchors for predicting toxicity. The second work stream would focus on integration and application of new approach methods for hazard (and risk) assessment within the current regulatory 'paradigm', aiming for acceptance of animal-free testing strategies by regulatory authorities (i.e. translating scientific achievements into regulation). Components for both work streams are discussed and may provide a structure for a future research programme in the field of predictive toxicology.
authors.affiliation: Central Product Safety Department, The Procter and Gamble Company, 8700 Mason Montgomery Road, Mason, OH, 45040, USA.
authors.forename: George
authors.initials: G
authors.lastname: Daston
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Knight
authors.forename: Michael
authors.initials: M
authors.lastname: Schwarz
authors.forename: Tilman
authors.initials: T
authors.lastname: Gocht
authors.forename: Russell S
authors.initials: RS
authors.lastname: Thomas
authors.forename: Catherine
authors.initials: C
authors.lastname: Mahony
authors.forename: Maurice
authors.initials: M
authors.lastname: Whelan
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods* / Q000639:trends; D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D003657:Decision Making; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D015386:Hazardous Substances / Q000493:pharmacokinetics / Q000633:toxicity*; D057166:High-Throughput Screening Assays; D006801:Humans; D012107:Research Design; D018570:Risk Assessment; D049490:Systems Biology; D018675:Toxicity Tests / Q000379:methods* / Q000639:trends; D043922:Toxicogenetics
chemical_list: D015386:Hazardous Substances