title: Palladium-catalyzed α-arylation of arylketones at low catalyst loadings.
abstract: A general catalytic protocol for the α-arylation of aryl ketones has been developed. It involves the use of a preformed, bench-stable Pd-N-heterocyclic carbene pre-catalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre-catalyst was also successfully tested in the synthesis of an industrially relevant compound.
authors.affiliation: EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST (UK).
authors.forename: Enrico
authors.initials: E
authors.lastname: Marelli
authors.forename: Martin
authors.initials: M
authors.lastname: Corpet
authors.forename: Sian R
authors.initials: SR
authors.lastname: Davies
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan
keywords: NHC; catalysts; ketone arylation; monodentate ligands; palladium