title: Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone.
abstract: This study investigated the effects of intraspecimen variations in tissue mineral density(TMD) on the apparent-level stiffness of human trabecular bone. High-resolution finite element (FE) models were created for each of 12 human trabecular bone specimens,using both microcomputed tomography (lCT) and “gold-standard” synchrotron radiation lCT (SRlCT) data. Our results confirm that incorporating TMD spatial variation reduces the calculated apparent stiffness compared to homogeneous TMD models. This effect exists for both lCT- and SRlCT-based FE models, but is exaggerated in lCT based models. This study provides a direct comparison of lCT to SRlCT data and is thereby able to conclude that the influence of including TMD heterogeneity is overestimated in lCT-based models.
authors.forename: Narges
authors.initials: N
authors.lastname: Kaynia
authors.forename: Elaine
authors.initials: E
authors.lastname: Soohoo
authors.forename: Tony M
authors.initials: TM
authors.lastname: Keaveny
authors.forename: Galateia J
authors.initials: GJ
authors.lastname: Kazakia
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D055595:Mechanical Phenomena; D008875:Middle Aged; D055114:X-Ray Microtomography