title: Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.
abstract: The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. Tissue array was conducted by using a tissue microarray instrument. Immunohistochemistry was performed to quantify the expressions of HER2 and FASN. The FASN was detected to be distributed in the cell cytoplasm and was significantly correlated with cancer grade (p = 0.000) and FIGO staging (p = 0.000). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000). HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer. It was also disclosed that FASN expression level is not correlated with HER2 status in ovarian cancer. These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.
authors.affiliation: Department of Obestetrics and Gynecology, Zhongda Hospital, Southeast University, Dingjia Qiao Road 87, Nanjing, 210009, Jiangsu Province, China.
authors.forename: Yunlang
authors.initials: Y
authors.lastname: Cai
authors.forename: Jingmei
authors.initials: J
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Dandan
authors.initials: D
authors.lastname: Yu
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Tian
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Xinru
authors.initials: X
authors.lastname: Jiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
authors.forename: Mulan
authors.initials: M
authors.lastname: Ren
authors.forename: Peilin
authors.initials: P
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D054890:Fatty Acid Synthase, Type I / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D020239:Receptor Cross-Talk; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D054890:Fatty Acid Synthase, Type I; D018719:Erb-b2 Receptor Tyrosine Kinases; C518729:FASN protein, human; C508053:ERBB2 protein, human