title: CLC-3 channels in cancer (review).
abstract: Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy.
authors.affiliation: Department of Physiology, The Basic Medical College, Jilin University, Changchun 130021, P.R. China.
authors.forename: Sen
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Ophthalmology, The China‑Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, P.R. China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Bi
authors.affiliation: Department of Colon and Anal Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Colon and Anal Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, P.R. China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Kang
authors.affiliation: Department of Colon and Anal Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, P.R. China.
authors.forename: Limian
authors.initials: L
authors.lastname: Ling
authors.affiliation: Department of Physiology, The Basic Medical College, Jilin University, Changchun 130021, P.R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D049109:Cell Proliferation; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D018118:Chloride Channels; C115376:ClC-3 channel