title: A catalytic borylation/dehalogenation route to o-fluoro arylboronates.
abstract: A two-step Ir-catalyzed borylation/Pd-catalyzed dehalogenation sequence allows for the net synthesis of fluoroarenes where the boronic ester is ortho to fluorine. Key elements of this approach include the use of a halogen para to the fluorine to block meta Ir-catalyzed borylation and the chemoselective Pd-catalyzed dehalogenation by KF activated polymethylhydrosiloxane (PMHS).
authors.affiliation: †Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824, United States.
authors.forename: Chathurika R K
authors.initials: CR
authors.lastname: Jayasundara
authors.affiliation: †Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824, United States.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Unold
authors.forename: Jossian
authors.initials: J
authors.lastname: Oppenheimer
authors.affiliation: †Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824, United States.
authors.forename: Milton R
authors.initials: MR
authors.lastname: Smith
authors.affiliation: †Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824, United States.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Maleczka
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001896:Boron Compounds; D006845:Hydrocarbons, Fluorinated; D012833:Siloxanes; C402373:poly(methylhydrosiloxane); D007495:Iridium; D010165:Palladium