title: Fatty acid composition indicates two types of metabolic syndrome independent of clinical and laboratory parameters.
abstract: Dietary composition and metabolism of fatty acids (FA) influence insulin resistance, atherogenic dyslipidemia and other components of the metabolic syndrome (MS). It is known that patients with MS exhibit a heterogeneous phenotype; however, the relationships of individual FA to MS components have not yet been consistently studied. We examined the plasma phosphatidylcholine FA composition of 166 individuals (68F/98M) with MS and of 188 (87F/101M) controls. Cluster analysis of FA divided the groups into two clusters. In cluster 1, there were 65.7 % of MS patients and 37.8 % of controls, cluster 2 contained 34.3 % of patients and 62.2 % of controls (P<0.001). Those with MS within cluster 1 (MS1) differed from individuals with MS in cluster 2 (MS2) by concentrations of glucose (P<0.05), NEFA (P<0.001), HOMA-IR (P<0.05), and levels of conjugated dienes in LDL (P<0.05). The FA composition in MS1 group differed from MS2 by higher contents of palmitoleic (+30 %), gamma-linolenic (+22 %), dihomo-gamma-linolenic (+9 %) acids and by a lower content of linoleic acid (-25 %) (all P<0.01). These FA patterns are supposed to be connected with the progression and/or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance).
authors.affiliation: Fourth Department of Medicine, First Medical Faculty, Charles University, General University Hospital in Prague, Czech Republic. azak@vfn.cz.
authors.forename: A
authors.initials: A
authors.lastname: Žák
authors.forename: M
authors.initials: M
authors.lastname: Burda
authors.forename: M
authors.initials: M
authors.lastname: Vecka
authors.forename: M
authors.initials: M
authors.lastname: Zeman
authors.forename: E
authors.initials: E
authors.lastname: Tvrzická
authors.forename: B
authors.initials: B
authors.lastname: Staňková
mesh_terms: D000368:Aged; D016000:Cluster Analysis; D005227:Fatty Acids / Q000097:blood*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000145:classification / Q000175:diagnosis*; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood*
chemical_list: D005227:Fatty Acids; D010713:Phosphatidylcholines