title: Pathophysiology of resistant hypertension in chronic kidney disease.
abstract: Hypertension associated with chronic kidney diseases often is resistant to drug treatment. This review deals with two main aspects of the management of CKD patients with hypertension: the role of sodium/volume and the need for dietary salt restriction, as well as appropriate use of diuretics and what currently is called sequential nephron blockade; the second aspect that is addressed extensively in this review is the role of the sympathetic nervous system and the possible clinical use of renal denervation.
authors.affiliation: Division of Nephrology, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address: campese@usc.edu.
authors.forename: Vito M
authors.initials: VM
authors.lastname: Campese
mesh_terms: D003329:Coronary Vasospasm / Q000150:complications; D004351:Drug Resistance; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery; D007668:Kidney / Q000294:innervation; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*; D012982:Sodium, Dietary / Q000378:metabolism*; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D012982:Sodium, Dietary
keywords: Hypertension; chronic kidney disease; renal denervation; sodium intake; sympathetic nervous system