title: Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.
abstract: An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Xian
authors.initials: X
authors.lastname: Feng
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Zhan
authors.initials: Z
authors.lastname: Xun
authors.forename: Jun-Die
authors.initials: JD
authors.lastname: Hu
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Zhao
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines
keywords: 1,8-naphthyridine; antitumor activity; cascade reaction; chromeno[2,3-b]quinoline