title: A combination of glucosyl hesperidin and caffeine exhibits an anti-obesity effect by inhibition of hepatic lipogenesis in mice.
abstract: To develop an anti-obesity agent, we examined the combination effect of glucosyl hesperidin (G-hesperidin) and caffeine on obesity in mice. High-fat diet-induced obese KK mice were fed a low-fat diet with or without G-hesperidin, caffeine, or their combination for 2 weeks. Decreases in body weight and significantly lower adipose tissue weight were observed in the combination-fed mice but not in the G-hesperidin-fed or caffeine-fed mice. DNA microarray analysis of mouse liver suggested that the feeding of G-hesperidin + caffeine was associated with lower lipogenesis. Therefore, we examined the anti-lipogenic effect of G-hesperidin + caffeine in fasted-refed KK mice. Hepatic triglyceride levels were significantly lower in the mice fed G-hesperidin + caffeine during the refeeding period but not in the mice fed each alone. In addition, hepatic expressions of genes related to lipogenesis, such as sterol regulatory element-binding protein-1c or fatty acid synthase, were significantly lower in the mice fed G-hesperidin + caffeine compared with that in the control mice. These results suggested that G-hesperidin + caffeine is effective for controlling obesity partly by the inhibition of hepatic lipogenesis.
authors.affiliation: Research and Development Institute, House Wellness Foods Corporation, Itami, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohara
authors.forename: Koutarou
authors.initials: K
authors.lastname: Muroyama
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Murosaki
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D059305:Diet, High-Fat; D064429:Fatty Acid Synthases / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D050155:Lipogenesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D005960:Glucosides; D008055:Lipids; D051780:Sterol Regulatory Element Binding Protein 1; D002110:Caffeine; C487382:glucosyl hesperidin; D006569:Hesperidin; D064429:Fatty Acid Synthases
keywords: anti-obesity effect; caffeine; glucosyl hesperidin; lipogenesis; liver