title: [Incidence and characteristics of calciphylaxis in Martinique (2006-2012)].
abstract: BACKGROUND
  Calciphylaxis is a rare and severe disease with an annual incidence of around 1 % in dialysis patients. The main study aim was to determine its incidence in Martinique, where there is a significant population of patients on dialysis.
  
  
  METHODS
  All patients diagnosed with calciphylaxis between 2006 and 2012 and living in Martinique were included, retrospectively. Social, demographic, biological, anatomic, pathological, histological and outcome data were analysed.
  
  
  RESULTS
  Fifteen patients were included (8 women, 7 men). The incidence of calciphylaxis in this population was about 4.62/1,000,000 inhabitants per year. All patients presented very painful skin ulcerations and necrosis, chiefly on the lower extremities in 53.3 % of cases. All patients were on haemodialysis and two had undergone renal transplantation. Fourteen of the 15 patients were presenting secondary hyperparathyroidism, 12 had hypertension, 9 peripheral arterial disease, 8 obesity and 8 diabetes mellitus. Raised calcium and phosphorus were noted in 8 patients, with hypoalbuminaemia in 9 patients. Treatment with sodium thiosulfate was given for 8 patients, and was beneficial for all after a mean duration of 3.4 months. After 6 months of follow-up, 8 of the 15 patients were cured, 1 showed improvement and 6 had died.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study to examine the incidence of calciphylaxis in the general population. The relatively large number of patients could be accounted for by the high number of comorbidities in end-stage renal disease patients in Martinique, including obesity, diabetes, hypertension and arteritis. Treatment with sodium thiosulfate was beneficial for 8 patients.
authors.affiliation: Service de dermatologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: A
authors.initials: A
authors.lastname: Aoun
authors.affiliation: Service de dermatologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: E
authors.initials: E
authors.lastname: Baubion
authors.affiliation: Service de dermatologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: R
authors.initials: R
authors.lastname: Banydeen
authors.affiliation: Service de néphrologie, CHU du Lamentin, rue Fernand-Guillon, 97232 Le Lamentin, Martinique.
authors.forename: I
authors.initials: I
authors.lastname: Djiconkpode
authors.affiliation: Laboratoire d'anatomopathologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: N
authors.initials: N
authors.lastname: Ekindi
authors.affiliation: Service de néphrologie et dialyse, clinique du Landy, 23, rue du Landy, 93400 Saint-Ouen, France.
authors.forename: P
authors.initials: P
authors.lastname: Ureña-Torres
authors.affiliation: Service d'endocrinologie, CHUM Trinité, rue Jean-Eugène-Fatier, 97235 La Trinité, Martinique.
authors.forename: A
authors.initials: A
authors.lastname: Riaux
authors.affiliation: Centre de dialyse Le Fort, 97290 Le Marin, Martinique.
authors.forename: T
authors.initials: T
authors.lastname: Sadreux
authors.affiliation: Service de néphrologie, CHU du Lamentin, rue Fernand-Guillon, 97232 Le Lamentin, Martinique.
authors.forename: J-M
authors.initials: JM
authors.lastname: Dueymes
authors.affiliation: Service de dermatologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique.
authors.forename: D
authors.initials: D
authors.lastname: Quist
authors.affiliation: Service de dermatologie, CHU de la Meynard, CS 90632, 97261 Fort-de-France, Martinique. Electronic address: cderancourt@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Derancourt
mesh_terms: D000671:Amputation, Surgical; D002115:Calciphylaxis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D007871:Leg Ulcer / Q000209:etiology; D008297:Male; D008395:Martinique / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011379:Prognosis; D006435:Renal Dialysis; D012189:Retrospective Studies; D013885:Thiosulfates / Q000627:therapeutic use
chemical_list: D013885:Thiosulfates; C017717:sodium thiosulfate
keywords: Calciphylaxie; Calciphylaxis; End-stage renal disease; Haemodialysis; Hémodialyse; Insuffisance rénale chronique terminale; Martinique; Sodium thiosulphate; Thiosulfate de sodium