title: Methylphenidate enhances neural stem cell differentiation.
abstract: BACKGROUND
  The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).
  
  
  CONCLUSIONS
  We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.
authors.affiliation: Hospital of Child and Adolescent Psychiatry, University of Zurich, Winterthurerstr. 180, Room L84/86, 8057 Zurich, Switzerland.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Bartl
authors.affiliation: Division of Neuropsychiatry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Riederer
authors.affiliation: Division of Neuropsychiatry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ozawa
authors.affiliation: Hospital of Child and Adolescent Psychiatry, University of Zurich, Winterthurerstr. 180, Room L84/86, 8057 Zurich, Switzerland ; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany ; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Kragujevac, Switzerland.
authors.forename: Edna
authors.initials: E
authors.lastname: Grünblatt
keywords: Cell proliferation; Methylphenidate; Neural stem cells; Neuronal maturation