title: A new phenylpropanoid from the roots of Euphorbia nematocypha.
abstract: A phytochemical investigation of the ethanolic extracts of the dried roots of Euphorbia nematocypha resulted in the isolation of a new phenylpropanoid, 16-O-caffeoyl-16-hydroxylhexadecanoic acid (1), together with 23 known compounds (2-24). Their structures were elucidated on the basis of spectroscopic data. Compound 1 was first to be isolated as a caffeic acyl long chain alkyl acid from the family Euphorbiaceae. The new isolated phenylpropanoid showed potent cytotoxic activities against the MCF-7 and HeLa cell lines.
authors.affiliation: a Department of Pharmaceutical Engineering , School of Chemistry and Chemical Engineering, Southeast University , Nanjing 211189 , PR China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Jia
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.forename: Fu-Yue
authors.initials: FY
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Wu
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Bo
authors.initials: B
authors.lastname: Zuo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D002109:Caffeic Acids / Q000737:chemistry* / Q000302:isolation & purification; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
chemical_list: C000598615:16-O-caffeoyl-16-hydroxylhexadecanoic acid; D000972:Antineoplastic Agents, Phytogenic; D002109:Caffeic Acids; C040048:caffeic acid
keywords: 16-O-caffeoyl-16-hydroxylhexadecanoic acid; Euphorbia nematocypha; eunicellan antiproliferative; phenylpropanoid