title: Transforming growth factor-β1 rs1800470 polymorphism is associated with lung cancer risk: a meta-analysis.
abstract: BACKGROUND
  Transforming growth factor-β1 is a member of a large class of polypeptides that regulate the proliferation, differentiation, and carcinogenesis of epithelial cells. The rs1800470 polymorphism influences transforming growth factor-β1 expression and has been associated with lung cancer susceptibility. However, the association between the rs1800470 polymorphism and lung cancer risk remains controversial. Thus, a meta-analysis was conducted.
  
  
  METHODS
  We comprehensively searched PubMed and EMBASE databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models.
  
  
  RESULTS
  Overall, there was a significant association between rs1800470 polymorphism and lung cancer susceptibility (OR=1.23; 95%CI, 1.03-1.47; P=0.02). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with lung cancer in Asians (OR=1.26; 95%CI, 1.01-1.57; P=0.04). However, we did not find any significant association between this polymorphism and lung cancer risk in Caucasians (OR=1.04; 95%CI, 0.60-1.82; P=0.88). In the NSCLC subgroup, we found that rs1800470 polymorphism could increase NSCLC risk (OR=1.36; 95%CI, 1.06-1.74; P=0.02).
  
  
  CONCLUSIONS
  This meta-analysis suggested that rs1800470 polymorphism was a risk factor of lung cancer.
authors.affiliation: Department of Respiratory Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
authors.forename: Huizhen
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Respiratory Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
authors.forename: Huapeng
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Respiratory Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
authors.forename: Huojin
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Respiratory Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou, China (mainland).
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1