title: Association between Apolipoprotein E Polymorphism and Chronic Kidney Disease in the Korean General Population: Dong-gu Study.
abstract: BACKGROUND
  Few studies have investigated the association between Apolipoprotein E (APOE) polymorphisms and chronic kidney disease (CKD) in the general population, and their results are inconsistent.
  
  
  METHODS
  The current study population was composed of 9,033 subjects aged ≥ 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in Korea between 2007 and 2010. APOE polymorphisms were identified by polymerase chain reaction, and the estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease equation.
  
  
  RESULTS
  Individuals with the APOE E2 allele had significantly lower total and low density lipoprotein cholesterol levels, those with the APOE E4 allele had lower high density lipoprotein (HDL) cholesterol levels, and those with the APOE E3 allele had lower log-triglyceride levels. Adjusting for covariates (sex, age, body mass index, smoking, systolic blood pressure, hypertension, diabetes, total cholesterol, HDL cholesterol, log-transformed triglycerides, and log-transformed albumin to creatinine ratio), mean eGFR was not significantly different among APOE alleles (E2, 69.4 mL/min/1.73 m(2); E3, 69.5 mL/min/1.73 m(2); E4, 69.4 ml/min/1.73 m(2); P = 0.873). Additionally, the odds ratios (ORs) indicated that APOE polymorphisms were not independent risk factors for CKD (OR, 1.07; 95% confidence interval [CI], 0.91 to 1.26 for the E2 vs. E3 allele; OR, 1.01; 95% CI, 0.88 to 1.16 for the E4 vs. E3 allele).
  
  
  CONCLUSIONS
  APOE polymorphisms were not associated with either eGFR or CKD in the general Korean population.
authors.affiliation: Department of Preventive Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. ; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.affiliation: Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Hae-Sung
authors.initials: HS
authors.lastname: Nam
authors.affiliation: Department of Neurology & Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.affiliation: Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea.
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
keywords: Apolipoprotein E; Polymorphism, Genetic; Renal Insufficiency, Chronic