title: Cinnamomum cassia bark produced by solid-state fermentation with Phellinus baumii has the potential to alleviate atopic dermatitis-related symptoms.
abstract: In order to evaluate whether the aqueous fraction of Cinnamomum cassia produced by solid-state fermentation with Phellinus baumii (afCc/Pb) inhibits atopic symptoms in vivo, its efficacy was evaluated in an animal model of 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis. Immune-related cells were quantified using hematoxylin and eosin staining, and phenotypic cytokines, enzymes and the expression of other proteins in the animal model were evaluated. The data revealed that afCc/Pb (100 µg/ml) exhibited strong anti-atopic activity, causing a significant 40% reduction in immune response, as shown by the extent of ear swelling, resulting from a decrease in the number of eosinophils in the skin tissues due to decreased matrix metalloproteinase-2 and interleukin-31 expression. These results collectively suggest that afCc/Pb has the potential to alleviate the symptoms of atopic dermatitis in a mouse model of DNFB-induced atopic dermatitis, and that it may be a valuable bioresource for the cosmetic/cosmeceutical industry.
authors.affiliation: Department of Microbiology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Yong-Kyu
authors.initials: YK
authors.lastname: Shin
authors.affiliation: Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Hyeong-U
authors.initials: HU
authors.lastname: Son
authors.affiliation: Farmbios Co. Ltd., Techno Building, Daegu 702-701, Republic of Korea.
authors.forename: Jong-Myung
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Food and Bio‑Industry Research Institute, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Jin-Chul
authors.initials: JC
authors.lastname: Heo
authors.affiliation: Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Sang-Han
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Microbiology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Jong-Guk
authors.initials: JG
authors.lastname: Kim
mesh_terms: D000818:Animals; D001487:Basidiomycota; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005285:Fermentation; D008297:Male; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D010936:Plant Extracts; D020782:Matrix Metalloproteinases