title: [Acute localized exanthematous pustulosis on the face: 6 cases in Tunisia].
abstract: BACKGROUND
  Acute localized exanthematous pustulosis (ALEP) is a rare and localized variant of acute generalized exanthematous pustulosis (AGEP). Only 15 cases of ALEP have been reported to date in the literature, with all cases following drug administration. We report 6 paediatric cases of ALEP occurring in springtime, with no associated drug administration in any case.
  
  
  METHODS
  Over the last three years (2011, 2012 and 2013), we observed 6 cases of ALEP in 6 Tunisian children aged between 9 and 14 years. All cases were observed during the spring months. Diagnosis of ALEP was based in all cases on the EuroSCAR criteria and on the definition of ALEP proposed by Prange et al. A drug-related aetiology was ruled out in all cases, with exposure to a specific planned plant (Thapsia garganica) being retained as an aetiological factor in one case.
  
  
  CONCLUSIONS
  Drug administration is the most frequent though not the sole cause of ALEP. The seasonal nature of this dermatosis may suggest other causes, mainly viral infection, plant contact or airborne allergens.
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie. Electronic address: mariemmohamed79@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Mohamed
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie.
authors.forename: Y
authors.initials: Y
authors.lastname: Soua
authors.affiliation: Service d'anatomo-pathologie, CHU de Monastir, 5000 Monastir, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Njim
authors.affiliation: Service de pédiatrie, CHU de Monastir, 5000 Monastir, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Hammemi
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Youssef
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Akkari
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Belhadjali
authors.affiliation: Service de dermatologie, CHU de Monastir, R4, N 112, 5000 Monastir, Tunisie.
authors.forename: J
authors.initials: J
authors.lastname: Zili
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D005260:Female; D035264:Flowers / Q000009:adverse effects; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D008297:Male; D012621:Seasons; D053629:Thapsia / Q000009:adverse effects; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents
keywords: Acute localized exanthematous pustulosis; Children; Enfant; Plant; Plantes; Printemps; Pustulose exanthématique aiguë localisée; Spring; Thapsia garganica