title: Clinical spectrum of cutaneous manifestations in renal and renopancreatic recipients in two centers in Uruguay.
abstract: Uruguay, with a total population of 3,345,000 inhabitants, is the Latin American country with the second highest number of renal replacement therapies. Long-term immunosuppressant therapy is essential for graft survival but results in reduced immunosurveillance, leading to an increased risk of complications. A variety of dermatological manifestations and a large increase in nonmelanoma skin cancers have been reported in this population. The purpose of this study was to evaluate the frequency and clinical spectrum of cutaneous manifestations in renal and renopancreatic recipients in 2 reference centers in Uruguay. Two hundred and six renal or renopancreatic recipients between 21 and 77 years old were evaluated between September 2009 and September 2011. A total of 206 dermatoses were observed; 60% of the patients had at least 1 cutaneous manifestation. The most frequent dermatoses were cutaneous side effects due to immunosuppressive treatment (40.6%), followed by infections (26.1%), miscellaneous causes (18.9%), and malignant and premalignant lesions (14.4%). Transplant recipients represent a high-risk dermatological population. Physicians in transplant units should be aware of the importance of dermatological screening in order to promote early detection of skin cancer.
authors.affiliation: Dermatology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay. Electronic address: ldufrechou@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Dufrechou
authors.affiliation: Nephrology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay; Instituto de Nefrología y Urología, Montevideo, Uruguay.
authors.forename: M
authors.initials: M
authors.lastname: Nin
authors.affiliation: Instituto de Nefrología y Urología, Montevideo, Uruguay.
authors.forename: L
authors.initials: L
authors.lastname: Curi
authors.affiliation: Nephrology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay; Instituto de Nefrología y Urología, Montevideo, Uruguay.
authors.forename: P
authors.initials: P
authors.lastname: Larre Borges
authors.affiliation: Dermatology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay.
authors.forename: M
authors.initials: M
authors.lastname: Martínez Asuaga
authors.affiliation: Nephrology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay.
authors.forename: O
authors.initials: O
authors.lastname: Noboa
authors.affiliation: Instituto de Nefrología y Urología, Montevideo, Uruguay.
authors.forename: S
authors.initials: S
authors.lastname: Orihuela
authors.affiliation: Nephrology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay; Instituto de Nefrología y Urología, Montevideo, Uruguay.
authors.forename: F
authors.initials: F
authors.lastname: González-Martínez
authors.affiliation: Dermatology Department, Hospital de Clínicas "Dr. Manuel Quintela," Montevideo, Uruguay.
authors.forename: A
authors.initials: A
authors.lastname: Larre Borges
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D055623:Keratosis, Actinic / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000139:chemically induced / Q000453:epidemiology*; D012871:Skin Diseases / Q000139:chemically induced / Q000453:epidemiology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D014583:Uruguay / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents