title: Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis.
abstract: N-methyl-d-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: Katherine
authors.initials: K
authors.lastname: Beck
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Lally
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: Sukhwinder S
authors.initials: SS
authors.lastname: Shergill
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: Michael A P
authors.initials: MA
authors.lastname: Bloomfield
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: James H
authors.initials: JH
authors.lastname: MacCabe
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Gaughran
authors.affiliation: Katherine Beck, MRCPsych, John Lally, MRCPsych, Sukhwinder S. Shergill, MBBS, FRCPsych, PhD, Michael A. P. Bloomfield, MRCPsych, James H. MacCabe, MRCPsych, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London; Fiona Gaughran, FRCP(I), FRCP, FRCPsych, MD, National Psychosis Service, South London and Maudsley NHS Foundation Trust, London; Oliver D. Howes, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Howes
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate