title: Could elevated platelet-lymphocyte ratio predict left ventricular systolic dysfunction in patients with non-ST elevated acute coronary syndrome?
abstract: OBJECTIVE
  The prognostic value of a high platelet-lymphocyte ratio (PLR) has been reported in patients with non-ST elevated myocardial infarction (NSTEMI) and different oncologic disorders. We aimed to evaluate the predictive value of the PLR for left ventricular systolic dysfunction (LVSD) in patients with non-ST elevated acute coronary syndrome (NST-ACS).
  
  
  METHODS
  A total of 220 patients with NST-ACS were included in the study. The study population was divided into tertiles based on admission PLR values. High (n=73) and low PLR (n=147) groups were defined as patients having values in the third tertile (>135.6) and lower 2 tertiles (≤ 135.6), respectively. Left ventricular dysfunction was defined as ejection fraction ≤ 40%, and related variables were evaluated by backward conditional binary logistic regression analysis.
  
  
  RESULTS
  The patients in the high PLR group were older (p<0.001) and had a higher rate of previous myocardial infarction and NSTEMI (p=0.046, p=0.013, respectively). There were significantly more coronary arteries narrowed (p=0.001) and lower left ventricular ejection fraction (p<0.001) in the high PLR group. Baseline platelet levels were significantly higher (p<0.001) and triglyceride and lymphocyte levels were significantly lower (p=0.009 and p<0.001, respectively) in the high PLR group. PLR >135.6 was found to be an independent predictor of systolic dysfunction in the multivariate analyses (β: 0.306, 95% confidence interval: 0.151-0.619; p=0.001).
  
  
  CONCLUSIONS
  A high PLR is a strong and independent predictor for LVSD in patients with NST-ACS.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University; Çanakkale-Turkey. adembekler27@gmail.com.
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutçu
authors.forename: Tezcan
authors.initials: T
authors.lastname: Peker
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D000368:Aged; D001792:Blood Platelets; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging