title: NAFLD Prevalence in a Young Cadaveric Organ Donor Population.
abstract: BACKGROUND
  Liver transplantation is a critical survival point for patients with end stage liver diseases. It can dramatically increase patients' survival if the donor liver is intact. One aspect of liver health is absence of steatosis. Nonalcoholic Steato Hepatitis (NASH) and Nonalcoholic Fatty Liver Disease (NAFLD) are increasing among young adults and patients living with chronic liver diseases.
  
  
  OBJECTIVE
  In this study, we determined the prevalence of NALFD in livers of brain-dead donors in Imam-Khomeini hospital Complex, Tehran, Iran. We assumed that the calculated prevalence would represent NAFLD prevalence in Iranian population in the age range of 20-60 years.
  
  
  METHODS
  All eligible brain dead liver transplant donors were enrolled in the survey from March 21, 2011 to March 21, 2013 in Imam-Khomeini hospital Complex. Eligible participants were donors aged 20 to 60 years without any obvious history of liver disease. Liver needle biopsy was performed at the end of the transplant operation; time zero biopsy. We calculated the prevalence of NAFLD among brain-dead donors. Moreover, the frequency of NASH was calculated based on the NAS (NAFLD Activity Score).
  
  
  RESULTS
  Among 116 cases, two were diagnosed as probable NASH. There was a significant association between NAFLD and male gender (P = 0.04). Moreover, we found a higher steatosis level in male gender. There was a significant association between NAFLD and BMI (P = 0.05). Those with BMI more than 27 had severe steatosis.
  
  
  CONCLUSIONS
  Our comprehensive literature review showed that our study was the first investigation in Iran and the region, which determined the prevalence of NAFLD based on tissue diagnosis. We believe that the prevalence of NAFLD/NASH in our donors can represent the overall prevalence in this age group in Iran.
authors.affiliation: Hepatobiliary and Liver Transplantation Division, Department of General Surgery, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Jafarian
authors.affiliation: Hepatobiliary and Liver Transplantation Division, Department of General Surgery, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Amirpasha
authors.initials: A
authors.lastname: Ebrahimi
authors.affiliation: Department of Pathology, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Azmoudeh Ardalan
authors.affiliation: Hepatobiliary and Liver Transplantation Division, Department of General Surgery, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Habibollah
authors.initials: H
authors.lastname: Dashti
authors.affiliation: Department of Anesthesiology and Intensive Care, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: Hepatobiliary and Liver Transplantation Division, Department of General Surgery, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Salehi
authors.affiliation: Gastroenterology Division, Internal Medicine Department, Imam-Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nasiri Toosi
keywords: Cadaver; NAFLD; NASH; Prevalence; Steatosis