title: Cytotoxicity potentials of eleven Bangladeshi medicinal plants.
abstract: Various forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. In this study, fourteen extracts of different parts of eleven Bangladeshi medicinal plants which have been traditionally used for the treatment of different types of carcinoma, tumor, leprosy, and diseases associated with cancer were evaluated for their cytotoxicity for the first time. Extraction was conceded using methanol. Phytochemical groups like reducing sugars, tannins, saponins, steroids, gums, flavonoids, and alkaloids were tested using standard chromogenic reagents. Plants were evaluated for cytotoxicity by brine shrimp lethality bioassay using Artemia salina comparing with standard anticancer drug vincristine sulphate. All the extracts showed potent to moderate cytotoxicity ranging from LC50 2 to 115 µg/mL. The highest toxicity was shown by Hygrophila spinosa seeds (LC50 = 2.93 µg/mL) and the lowest by Litsea glutinosa leaves (LC50 = 114.71 µg/mL) in comparison with standard vincristine sulphate (LC50 = 2.04 µg/mL). Among the plants, the plants traditionally used in different cancer and microbial treatments showed highest cytotoxicity. The results support their ethnomedicinal uses and require advanced investigation to elucidate responsible compounds as well as their mode of action.
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh.
authors.forename: Amina
authors.identifier: 0000-0002-5631-8574
authors.initials: A
authors.lastname: Khatun
authors.affiliation: Natural Product and Drug Discovery Lab, Department of Pharmacy, Faculty of Health Sciences, Northern University Bangladesh, 24 Mirpur Road, Dhaka 1205, Bangladesh.
authors.forename: Mahmudur
authors.identifier: 0000-0003-2408-3958
authors.initials: M
authors.lastname: Rahman
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh.
authors.forename: Tania
authors.initials: T
authors.lastname: Haque
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh ; Product Management Department, The IBN Sina Pharmaceutical Industry Ltd., House No. 41, Road No. 10/A, Dhanmondi R/A, Dhaka 1205, Bangladesh.
authors.forename: Md Mahfizur
authors.identifier: 0000-0002-5498-0433
authors.initials: MM
authors.lastname: Rahman
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh.
authors.forename: Mahfuja
authors.initials: M
authors.lastname: Akter
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh.
authors.forename: Subarna
authors.initials: S
authors.lastname: Akter
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, Bangladesh.
authors.forename: Afrin
authors.initials: A
authors.lastname: Jhumur
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects / Q000502:physiology; D001459:Bangladesh; D001681:Biological Assay; D005419:Flavonoids / Q000302:isolation & purification / Q000633:toxicity; D020128:Inhibitory Concentration 50; D000432:Methanol; D010840:Phytosterols / Q000302:isolation & purification / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000633:toxicity; D012997:Solvents; D013634:Tannins / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010840:Phytosterols; D010936:Plant Extracts; D012503:Saponins; D012997:Solvents; D013634:Tannins; D000432:Methanol