title: Formulation of spray congealed microparticles with self-emulsifying ability for enhanced glibenclamide dissolution performance.
abstract: OBJECTIVE
  To develop a novel preparation approach of solid Self-Emulsifying Drug Delivery System (s-SEDDS) based on spray congealing as potential drug delivery technology for poorly water-soluble drug Glibenclamide (GBD).
  
  
  METHODS
  Several systems were formulated using suitable excipients, solid at room temperature, with different hydrophilic-lipophilic balance, such as Myverol, Myvatex, Gelucire®50/13 and Gelucire®44/14. Cremophor®EL and Poloxamer 188 were selected as surfactants and PEG 4000 as co-solvent.
  
  
  RESULTS
  The screening of the best carrier for s-SEDDS manufacturing revealed that Gelucire®50/13 had greater performance. Then, surfactant-co-solvent systems were developed. Dissolution studies showed that all the formulations promoted the solubilisation performance of the GBD with respect to pure drug; in particular the formulation containing Gelucire®50/13 and PEG 4000 increased the drug solubilisation of five times. These microparticles showed self-dispersibility within 60 min and micelles dimensions around 360 nm.
  
  
  CONCLUSIONS
  Spray congealing is a promising novel manufacturing technique of solid self-emulsifying systems.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna , Bologna , Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Albertini
authors.forename: Marcello Di
authors.initials: MD
authors.lastname: Sabatino
authors.forename: Cecilia
authors.initials: C
authors.lastname: Melegari
authors.forename: Nadia
authors.initials: N
authors.lastname: Passerini
mesh_terms: D065546:Drug Liberation; D004655:Emulsions; D005905:Glyburide / Q000737:chemistry / Q000493:pharmacokinetics; D058993:Oral Sprays; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D013501:Surface-Active Agents / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004655:Emulsions; D058993:Oral Sprays; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; C000595213:polyethylene glycol 400; D005905:Glyburide
keywords: Dissolution profiles; poorly water-soluble drug; solid SEDDS; spray congealing; surfactant–co-solvent systems