title: Implementation of gastric cancer screening - the global experience.
abstract: Gastric cancer (GC) is still an important global healthcare problem, and in absolute figures it is going to remain at the present level in foreseeable future. In general, survival of patients with GC is poor mainly due to advanced-stage diagnosis. Early-stage GC can be cured by endoscopic resection or less invasive surgical treatment. Unfortunately, there is no appropriate screening strategy available for global application. This article provides a description of established national and regional GC screening programs and the screening modalities used. This review also summarizes current approaches to develop cancer-screening biomarkers. Although candidates with initial promising results have been suggested, moving discovery into clinical practice is still a major challenge. Well-designed biomarker studies, with systematic validation steps, are needed to decrease the burden of this fatal disease.
authors.affiliation: Faculty of Medicine, University of Latvia, 6 Linezera iela, LV1006 Riga, Latvia. Electronic address: cei@latnet.lv.
authors.forename: Mārcis
authors.initials: M
authors.lastname: Leja
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, PR China. Electronic address: weichengyou@yahoo.com.
authors.forename: Weicheng
authors.initials: W
authors.lastname: You
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. Electronic address: camargomc@mail.nih.gov.
authors.forename: M Constanza
authors.initials: MC
authors.lastname: Camargo
authors.affiliation: Cancer Screening Assessment & Management Division, Research Center for Cancer Prevention & Detection, National Cancer Center, Tokyo 104-0045, Japan. Electronic address: hrsaito@ncc.go.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
mesh_terms: D014408:Biomarkers, Tumor; D055088:Early Detection of Cancer; D014943:Global Health; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarkers; Gastric cancer; Helicobacter pylori; Precancerous lesions; Screening