title: Vitamin E attenuates neurotoxicity induced by deltamethrin in rats.
abstract: BACKGROUND
  The safety of Deltamethrin (DM) has been raised as a point of concern. The current investigation was envisaged to explore the responsiveness of oxidative stress parameters, DNA fragmentation and expression levels of TP53, cycloxygenase 2 (COX2) and cytochrome p4502E1 (CYP2E1) as toxicological endpoint in rats treated with DM. as well as attention was provided to the neuroprotective effect of vitamin E (VE).
  
  
  METHODS
  Four different groups of rats were used in this study, group I served as control, group II received DM (0.6 mg/kg BW), group III received both DM plus VE and finally group IV received VE only (200 mg/kg BW). The treatment regimen was extending for one month for all groups and the brain tissues were collected for further analysis.
  
  
  RESULTS
  The obtained results showed a highly statistically significant increase in lipid peroxidation (LPO) content, nitric oxide concentration, and DNA fragmentation percentage and expression level of CYP2E1, TP53 and COX2 genes, in addition statistical significant reduction in total antioxidant capacity in DM treated group as compared to control were detected. Oral administration of VE attenuated the neurotoxic effects of DM through improvement of oxidative status, DNA fragmentation percentage and suppressing the expression level of CYP2E1, TP53 and COX2 genes.
  
  
  CONCLUSIONS
  From this study we concluded that VE supplementation has beneficial impacts on DM neurotoxicity in rats through its antioxidant and antiapoptotic properties.
authors.affiliation: Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt. monagalal12@gmail.com.
authors.forename: Mona K
authors.initials: MK
authors.lastname: Galal
authors.forename: Abdel Azim A
authors.initials: AA
authors.lastname: Khalaf
authors.forename: Hanan A
authors.initials: HA
authors.lastname: Ogaly
authors.forename: Marwa A
authors.initials: MA
authors.lastname: Ibrahim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D019587:Dietary Supplements; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000378:metabolism; D009570:Nitriles / Q000633:toxicity*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D018696:Neuroprotective Agents; D009570:Nitriles; D011722:Pyrethrins; D016159:Tumor Suppressor Protein p53; D014810:Vitamin E; C017180:decamethrin; D019392:Cytochrome P-450 CYP2E1; D051546:Cyclooxygenase 2