title: The equine immune responses to infectious and allergic disease: a model for humans?
abstract: The modern horse, Equus caballus has historically made important contributions to the field of immunology, dating back to Emil von Behring's description of curative antibodies in equine serum over a century ago. While the horse continues to play an important role in human serotherapy, the mouse has replaced the horse as the predominant experimental animal in immunology research. Nevertheless, continuing efforts have led to an improved understanding of the equine immune response in a variety of infectious and non-infectious diseases. Based on this information, we can begin to identify specific situations where the horse may provide a unique immunological model for certain human diseases.
authors.affiliation: Jes E. and Clementine Schlaikjer Chair in Equine Immunology, Maxwell Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546-0099, United States. Electronic address: DWHoro2@uky.edu.
authors.forename: David W
authors.initials: DW
authors.lastname: Horohov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006736:Horses / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007239:Infections / Q000276:immunology*; D051379:Mice
keywords: Allergy; Equine; Immunity; Infectious disease