title: Tumor M2-pyruvate kinase in stool as a biomarker for diagnosis of colorectal cancer: A meta-analysis.
abstract: OBJECTIVE
  The aim of this meta-analysis was to evaluate the diagnosis value of tumor M2-pyruvate kinase (M2-PK) in stool as a biomarker for diagnosis of colorectal cancer.
  
  
  METHODS
  By searching the databases of Cochrane Library, PubMed, China national knowledge Information and Wanfang, the diagnosis study related to tumor M2-PK in stool as a biomarker for diagnosis of colorectal cancer were screened and included in this study. The pooled sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR) and the receiver operating characteristic curve (ROC) were calculated by stata 11.0 software.
  
  
  RESULTS
  According to the including criteria, 14 trials including 1990 subjects were finally included in this meta-analysis. The pooled diagnosis sensitivity, specificity, +LR, -LR and area under curve were 0.78 (95% confidence interval [CI]: 0.74-0.81), 0.77 (95% CI: 0.76-0.79), 4.38 (95% CI: 3.27-5.88), 0.28 (95% CI: 0.23-0.34) and 0.86 (95% CI: 0.834-0.89). No statistical publication bias was found in this study.
  
  
  CONCLUSIONS
  Tumor M2-PK in stool can be a useful biomarker in the diagnosis of colorectal cancer with relative high sensitivity and specificity.
authors.forename: Jin-Xi
authors.initials: JX
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Cheng-Hu
authors.initials: CH
authors.lastname: Wang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Yuan
authors.forename: Zhan-Dong
authors.initials: ZD
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Henan Zhengzhou 450052, China.
authors.forename: Xie-Fu
authors.initials: XF
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D011770:Pyruvate Kinase / Q000378:metabolism*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D014408:Biomarkers, Tumor; D011770:Pyruvate Kinase