title: Adaptive robust control of cancer chemotherapy in the presence of parametric uncertainties: a comparison between three hypotheses.
abstract: In this paper, an adaptive robust control strategy is developed for the manipulation of drug usage and consequently the tumor volume in cancer chemotherapy. Three nonlinear mathematical cell-kill models including log-kill hypothesis, Norton-Simon hypothesis and E(max) hypothesis are considered in the presence of uncertainties. The Lyapunov stability theorem is used to investigate the global stability and tracking convergence of the process response. For the first time, performance of the uncertain process is investigated and compared for three nonlinear models. In addition, the effects of treatment period, initial value of tumor volume (carrying capacity) and the uncertainty amount on dynamic system behaviour are studied. Through a comprehensive evaluation, results are presented and compared for three cell-kill models. According to the results, for a wide range of model uncertainties, the adaptive controller guarantees the robust performance. However, for a given treatment period, more variation in drug usage is required as the amount of model uncertainty increases. Moreover, for both the nominal and uncertain models, less drug usage is required as the treatment period increases.
authors.affiliation: Centre of Excellence in Design, Robotics and Automation, School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. Electronic address: hamedmoradi@sharif.edu.
authors.forename: Hamed
authors.initials: H
authors.lastname: Moradi
authors.affiliation: Centre of Excellence in Design, Robotics and Automation, School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Sharifi
authors.affiliation: Centre of Excellence in Design, Robotics and Automation, School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Vossoughi
mesh_terms: D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
keywords: Adaptive control; Cancer chemotherapy; Lyapunov stability; Model uncertainty; Robust performance