title: Computer-automated time-lapse analysis results correlate with embryo implantation and clinical pregnancy: a blinded, multi-centre study.
abstract: Computer-automated time-lapse analysis has been shown to improve embryo selection by providing quantitative and objective information to supplement traditional morphology. In this multi-centre study, the relationship between such computer-derived outputs (High, Medium, Low scores), embryo implantation and clinical pregnancy were examined. Data were collected from six clinics, including 205 patients whose embryos were imaged by the Eeva(TM) System. The Eeva scores were blinded and not considered during embryo selection. Embryos with High and Medium scores had significantly higher implantation rates than those with Low scores (37% and 35% versus 15%; P < 0.0001; P = 0.0004). Similar trends in implantation rates were observed in different IVF centres each using their own protocols. Further analysis revealed that patients with at least one High embryo transferred had significantly higher clinical pregnancy rates than those with only Low embryos transferred (51% versus 34%; P = 0.02), although patients' clinical characteristics across groups were comparable. These data, together with previous research and clinical studies, confirm that computer-automated Eeva scores provide valuable information, which may improve the clinical outcome of IVF procedures and ultimately facilitate the trend of single embryo selection.
authors.affiliation: Penn Fertility Care, University of Pennsylvania, 3701 Market St. Suite #800, Philadelphia, PA 19104, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: VerMilyea
authors.affiliation: Auxogyn, Inc, 1490 O'Brien Drive, Suite A, Menlo Park, CA 94025, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Penn Fertility Care, University of Pennsylvania, 3701 Market St. Suite #800, Philadelphia, PA 19104, USA.
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Anthony
authors.affiliation: Pacific Fertility Center, 55 Francisco Street, Fifth Floor, San Francisco, CA 94133, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Conaghan
authors.affiliation: Reproductive Science Center of the Bay Area, 3160 Crow Canyon Road, San Ramon, CA 94583, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Ivani
authors.affiliation: Palo Alto Medical Foundation Fertility, Fertility Physicians of Northern California, 2581 Samaritan Drive, San Jose, CA 95124, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Gvakharia
authors.affiliation: HRC Fertility, 15503 Ventura Blvd, Suite 200, Encino, CA 91436, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Boostanfar
authors.affiliation: Stanford Fertility & Reproductive Medicine Center, 900 Welch Road, Suite 350, Palo Alto, CA 94304, USA.
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Baker
authors.affiliation: Auxogyn, Inc, 1490 O'Brien Drive, Suite A, Menlo Park, CA 94025, USA.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suraj
authors.affiliation: Auxogyn, Inc, 1490 O'Brien Drive, Suite A, Menlo Park, CA 94025, USA.
authors.forename: Alice A
authors.initials: AA
authors.lastname: Chen
authors.affiliation: Penn Fertility Care, University of Pennsylvania, 3701 Market St. Suite #800, Philadelphia, PA 19104, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Mainigi
authors.affiliation: Penn Fertility Care, University of Pennsylvania, 3701 Market St. Suite #800, Philadelphia, PA 19104, USA.
authors.forename: Christos
authors.initials: C
authors.lastname: Coutifaris
authors.affiliation: Auxogyn, Inc, 1490 O'Brien Drive, Suite A, Menlo Park, CA 94025, USA. Electronic address: sshen@auxogyn.com.
authors.forename: Shehua
authors.initials: S
authors.lastname: Shen
mesh_terms: D010064:Embryo Implantation / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D059008:Time-Lapse Imaging / Q000379:methods*; D014481:United States
keywords: Eeva Test; embryo selection; implantation; in-vitro fertilization; pregnancy; time-lapse