title: Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.
abstract: Betulinic acid and analogous naturally occurring triterpenoid acids were transformed into the corresponding propargyl esters and subsequently deployed as substrates for a click chemistry-mediated coupling with azidothymidine (AZT) en route to novel 1,2,3-triazole-tethered triterpenoid-AZT conjugates. Twelve new hybrids were thus prepared and assessed in terms of their cytotoxic activity, revealing an interesting anticancer activity of five triterpenoid-AZT hybrids on KB and Hep-G2 tumor cell lines.
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Tuyet Anh
authors.initials: TA
authors.lastname: Dang Thi
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Kim Tuyet
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Chinh
authors.initials: C
authors.lastname: Pham The
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Ha
authors.initials: H
authors.lastname: Thanh Nguyen
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Cham
authors.initials: C
authors.lastname: Ba Thi
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Tien
authors.initials: T
authors.lastname: Doan Duy
authors.affiliation: SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: Matthias
authors.initials: M
authors.lastname: D'hooghe
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. Electronic address: ngvtuyen@hotmail.com.
authors.forename: Tuyen
authors.initials: T
authors.lastname: Van Nguyen
mesh_terms: D027481:Araliaceae; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D028001:Eleutherococcus; D004952:Esters; D056945:Hep G2 Cells; D006801:Humans; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D015215:Zidovudine / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D004952:Esters; D010936:Plant Extracts; D014230:Triazoles; D014315:Triterpenes; D015215:Zidovudine
keywords: AZT; Cytotoxic agents; Hybrids; Triterpenoids