title: Bionanocomposites containing magnetic graphite as potential systems for drug delivery.
abstract: New magnetic bio-hybrid matrices for potential application in drug delivery are developed from the assembly of the biopolymer alginate and magnetic graphite nanoparticles. Ibuprofen (IBU) intercalated in a Mg-Al layered double hydroxide (LDH) was chosen as a model drug delivery system (DDS) to be incorporated as third component of the magnetic bionanocomposite DDS. For comparative purposes DDS based on the incorporation of pure IBU in the magnetic bio-hybrid matrices were also studied. All the resulting magnetic bionanocomposites were processed as beads and films and characterized by different techniques with the aim to elucidate the role of the magnetic graphite on the systems, as well as that of the inorganic brucite-like layers in the drug-loaded LDH. In this way, the influence of both inorganic components on the mechanical properties, the water uptake ability, and the kinetics of the drug release from these magnetic systems were determined. In addition, the possibility of modulating the levels of IBU release by stimulating the bionanocomposites with an external magnetic field was also evaluated in in vitro assays.
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain; Universidade Federal de São Carlos (UFSCar), Departamento de Física, Rodovia Washington Luis Km 235, Monjolinho,13565-905 São Carlos, SP, Brazil; Embrapa Instrumentação Agropecuária, CP 741, 13560-970 São Carlos, SP, Brazil.
authors.forename: Lígia N M
authors.initials: LN
authors.lastname: Ribeiro
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Ana C S
authors.initials: AC
authors.lastname: Alcântara
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Darder
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Aranda
authors.affiliation: Embrapa Instrumentação Agropecuária, CP 741, 13560-970 São Carlos, SP, Brazil.
authors.forename: Paulo S P
authors.initials: PS
authors.lastname: Herrmann
authors.affiliation: Universidade Federal de São Carlos (UFSCar), Departamento de Física, Rodovia Washington Luis Km 235, Monjolinho,13565-905 São Carlos, SP, Brazil.
authors.forename: Fernando M
authors.initials: FM
authors.lastname: Araújo-Moreira
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: García-Hernández
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain. Electronic address: eduardo@icmm.csic.es.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz-Hitzky
mesh_terms: D000464:Alginates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry; D006878:Hydroxides / Q000008:administration & dosage / Q000737:chemistry; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D006878:Hydroxides; D058185:Magnetite Nanoparticles; D006108:Graphite; D020723:Glucuronic Acid; D007052:Ibuprofen
keywords: Alginate; Bionanocomposites; Controlled release; Drug delivery; Ibuprofen; Layered double hydroxides; Magnetic graphite