title: Dietary models of insulin resistance.
abstract: Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained. Dietary macronutrient composition has been examined in a number of articles, and diets enriched in saturated fatty acids, and possibly in fructose, appear to be most consistently associated with the development of insulin resistance. However, mechanistic insights into the metabolic effects of such diets are lacking, and merit further study.
authors.affiliation: Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892. Electronic address: james.deer@dignityhealth.org.
authors.forename: James
authors.initials: J
authors.lastname: Deer
authors.affiliation: Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892.
authors.forename: Juraj
authors.initials: J
authors.lastname: Koska
authors.affiliation: Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892.
authors.forename: Marlies
authors.initials: M
authors.lastname: Ozias
authors.affiliation: Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892.
authors.forename: Peter
authors.initials: P
authors.lastname: Reaven
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism; D004734:Energy Metabolism; D005632:Fructose / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008954:Models, Biological
chemical_list: D004041:Dietary Fats; D005632:Fructose
keywords: Carbohydrate; Dietary composition; Fat; Insulin resistance