title: Clinical impact of primary infection with roseoloviruses.
abstract: The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe neurologic complications and accounts for a significant portion of healthcare utilization by young children. Recent advances have underscored the association of HHV-6B and HHV-7 primary infection with febrile status epilepticus as well as the role of reactivation of latent infection in encephalitis following cord blood stem cell transplantation.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA.
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Tesini
authors.affiliation: Departments of Pediatrics and Neurology, Feinberg School of Medicine, Northwestern University and the Ann & Robert H. Lurie Children's Hospital of Chicago, Box 51, 225 E Chicago Ave, Chicago, IL 60611, USA.
authors.forename: Leon G
authors.initials: LG
authors.lastname: Epstein
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA. Electronic address: mary_caserta@urmc.rochester.edu.
authors.forename: Mary T
authors.initials: MT
authors.lastname: Caserta
mesh_terms: D015654:Herpesvirus 6, Human / Q000502:physiology; D016199:Herpesvirus 7, Human / Q000502:physiology; D006801:Humans; D015995:Prevalence; D019349:Roseolovirus Infections / Q000150:complications / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology