title: Clinical utility of quantitative imaging.
abstract: Quantitative imaging (QI) is increasingly applied in modern radiology practice, assisting in the clinical assessment of many patients and providing a source of biomarkers for a spectrum of diseases. QI is commonly used to inform patient diagnosis or prognosis, determine the choice of therapy, or monitor therapy response. Because most radiologists will likely implement some QI tools to meet the patient care needs of their referring clinicians, it is important for all radiologists to become familiar with the strengths and limitations of QI. The Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force has explored the clinical application of QI and summarizes its work in this review. We provide an overview of the clinical use of QI by discussing QI tools that are currently used in clinical practice, clinical applications of these tools, approaches to reporting of QI, and challenges to implementing QI. It is hoped that these insights will help radiologists recognize the tangible benefits of QI to their patients, their referring clinicians, and their own radiology practice.
authors.affiliation: Department of Radiology, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016. Electronic address: Andrew.Rosenkrantz@nyumc.org.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Rosenkrantz
authors.affiliation: Henry Ford Hospital, Abdominal and Cross-sectional Interventional Radiology, Detroit, Michigan.
authors.forename: Mishal
authors.initials: M
authors.lastname: Mendiratta-Lala
authors.affiliation: Division of Radiology Informatics, Mayo Clinic in Rochester, Rochester, Minnesota.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bartholmai
authors.affiliation: Department of Abdominal Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Dhakshinamoorthy
authors.initials: D
authors.lastname: Ganeshan
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Abramson
authors.affiliation: Department of Medical Imaging and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kirsteen R
authors.initials: KR
authors.lastname: Burton
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
authors.forename: John-Paul J
authors.initials: JP
authors.lastname: Yu
authors.affiliation: Department of Radiology, SUNY Upstate Medical University, Syracuse New York.
authors.forename: Ernest M
authors.initials: EM
authors.lastname: Scalzetti
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Yankeelov
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, and Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Rathan M
authors.initials: RM
authors.lastname: Subramaniam
authors.affiliation: Department of Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.
authors.forename: Leon
authors.initials: L
authors.lastname: Lenchik
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D005069:Evaluation Studies as Topic; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D015336:Molecular Probe Techniques; D015335:Molecular Probes
chemical_list: D015415:Biomarkers; D015335:Molecular Probes
keywords: Radiology; biomarker; quantitative imaging; radiologist