title: FDTD-based Transcranial Magnetic Stimulation model applied to specific neurodegenerative disorders.
abstract: Non-invasive treatment of neurodegenerative diseases is particularly challenging in Western countries, where the population age is increasing. In this work, magnetic propagation in human head is modelled by Finite-Difference Time-Domain (FDTD) method, taking into account specific characteristics of Transcranial Magnetic Stimulation (TMS) in neurodegenerative diseases. It uses a realistic high-resolution three-dimensional human head mesh. The numerical method is applied to the analysis of magnetic radiation distribution in the brain using two realistic magnetic source models: a circular coil and a figure-8 coil commonly employed in TMS. The complete model was applied to the study of magnetic stimulation in Alzheimer and Parkinson Diseases (AD, PD). The results show the electrical field distribution when magnetic stimulation is supplied to those brain areas of specific interest for each particular disease. Thereby the current approach entails a high potential for the establishment of the current underdeveloped TMS dosimetry in its emerging application to AD and PD.
authors.affiliation: Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, Spain. Electronic address: fanjulf@unican.es.
authors.forename: Félix
authors.initials: F
authors.lastname: Fanjul-Vélez
authors.affiliation: Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Salas-García
authors.affiliation: Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, Spain.
authors.forename: Noé
authors.initials: N
authors.lastname: Ortega-Quijano
authors.affiliation: Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Arce-Diego
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy; D001921:Brain / Q000473:pathology; D003198:Computer Simulation; D004574:Electromagnetic Fields; D020342:Finite Element Analysis; D006801:Humans; D008953:Models, Anatomic; D008959:Models, Neurological; D019636:Neurodegenerative Diseases / Q000628:therapy*; D010300:Parkinson Disease / Q000628:therapy; D013813:Therapy, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D050781:Transcranial Magnetic Stimulation / Q000379:methods* / Q000706:statistics & numerical data
keywords: Alzheimer disease; Circular coil; FDTD; Figure-8 coil; Parkinson disease; Transcranial Magnetic Stimulation