title: Keratitis caused by Absidia corymbifera in an immunocompetent male with no corneal injuries.
abstract: Case Report A healthy 55-years-old male went to emergency due to a white infiltrate in the left eye without corneal trauma which partially responds to antibiotic treatment. The infiltrate worsened by the use of topical steroids. Direct microscopic evaluation and Gram stain are a valuable diagnostic tool for the detection of Absidia filaments. There is a successful treatment with anphotericin and posaconazole. Discussion Keratitis caused by Zygomicetes are unusual. This is a rare condition in healthy patients with no corneal trauma. The treatment with amphotericin and posaconazole are synergistic against filamentous fungi.
authors.affiliation: FEA oftalmología,.Unidad de Superficie ocular y Córnea., Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España. Electronic address: dimeva23@hotmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Mesa Varona
authors.affiliation: FEA oftalmología,.Unidad de Superficie ocular y Córnea., Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
authors.forename: J
authors.initials: J
authors.lastname: Celis Sánchez
authors.affiliation: MIR oftalmología, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
authors.forename: L
authors.initials: L
authors.lastname: Alfaya Muñoz
authors.affiliation: FEA oftalmología,.Unidad de Superficie ocular y Córnea., Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
authors.forename: E M
authors.initials: EM
authors.lastname: Avendaño Cantos
authors.affiliation: FEA oftalmología. Unidad de Motilidad ocular y estrabismo, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
authors.forename: L
authors.initials: L
authors.lastname: Romero Moraleda
mesh_terms: D020095:Absidia / Q000187:drug effects / Q000302:isolation & purification*; D060433:Administration, Ophthalmic; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D004359:Drug Therapy, Combination; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D009883:Ophthalmic Solutions; D013194:Staining and Labeling; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole
keywords: Absidia corymbifera; Amphotericin; Anfotericina; Fungal keratitis; Queratitis fúngica