title: Effects of growth hormone excess on glycated albumin concentrations: Analysis in acromegalic patients.
abstract: BACKGROUND
  Glycated albumin (GA) does not reflect glycemic control in patients with disorders of albumin metabolism. In the present study, we examined GA concentrations in acromegalic patients with growth hormone (GH) excess.
  
  
  METHODS
  We studied the hormonal status of 29 acromegalic patients (10 patients had diabetes mellitus and the remaining 19 patients were non-diabetic), 20 patients with type 2 diabetes mellitus and 38 non-diabetic subjects matched for age, sex and body mass index.
  
  
  RESULTS
  Serum GA concentrations, but not those of fasting plasma glucose, 2-h post-load plasma glucose and HbA1c, were significantly higher in non-diabetic acromegalic patients compared with non-diabetic control subjects. Serum GA concentrations, but not those of fasting plasma glucose and HbA1c, were significantly higher in diabetic acromegalic patients compared with patients with type 2 diabetes mellitus.
  
  
  CONCLUSIONS
  This is the first report describing higher GA concentrations in acromegalic patients relative to plasma glucose concentrations. Special care should be taken when evaluating glycemic control using GA because acromegaly is frequently complicated with diabetes mellitus.
authors.affiliation: Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tamada
authors.affiliation: Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Otsuki
authors.affiliation: Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: Departments of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Oshino
authors.affiliation: Departments of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Saitoh
authors.affiliation: Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.affiliation: Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan. Electronic address: m-koga@kawanishi-city-hospital.com.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
mesh_terms: D000172:Acromegaly / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis*; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Acromegaly; Albumin; Glycated albumin; Growth hormone; HbA1c