title: Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
abstract: Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
authors.affiliation: Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lyons
authors.affiliation: Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Milner
authors.affiliation: Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: stonek@niaid.nih.gov.
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Stone
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D065095:Calcineurin Inhibitors / Q000627:therapeutic use; D002648:Child; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D004485:Eczema; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007589:Job Syndrome / Q000150:complications / Q000235:genetics; D007617:Kaposi Varicelliform Eruption / Q000150:complications; D056770:Netherton Syndrome / Q000150:complications / Q000235:genetics; D011537:Pruritus / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology*; D013207:Staphylococcal Skin Infections / Q000150:complications; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D065095:Calcineurin Inhibitors; D006633:Histamine Antagonists
keywords: Allergy; Atopic dermatitis; Eczema; Hyper-IgE syndrome; Netherton syndrome