title: Role of miRNAs in endometrial cancer.
abstract: Endometrial cancer (EC) is the most common gynecologic malignancy. MicroRNAs (miRNAs) were recently associated with carcinogenesis and progression of EC. In this review, we discuss recent advances and the emerging role of miRNAs in EC and their clinical implications, with special emphasis on the differences between deregulated miRNAs in type I and type II EC, as well as the impact of this dysregulation on EC initiation and progression.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shuangdi
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. maggie1974@126.com.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Shanghai Tong Ji University, Shanghai, China. Wanxiaoping61@126.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wan
mesh_terms: D019008:Drug Resistance, Neoplasm; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D009362:Neoplasm Metastasis; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D020813:Receptor, trkB; D015398:Signal Transduction
chemical_list: D047628:Estrogen Receptor alpha; D008562:Membrane Glycoproteins; D035683:MicroRNAs; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C506487:ESR1 protein, human; C000591259:tropomyosin-related kinase-B, human; C494929:PTEN protein, human