title: Evaluation of in vivo properties of Velosorb™ fast versus Vicryl™ rapide in a functional rabbit model of intradermic suture and episiotomy.
abstract: OBJECTIVE
  Fast-absorbing polyglactin 910 is commonly used to suture skin and vaginal incisions. In vitro studies have shown similar tensile strength properties between Velosorb™ Fast and Vicryl™ Rapide (Al-Qattan MM. J Hand Surg Br Eur. 2005;30(1):90-91). This randomized study compared Velosorb™ Fast (Covidien) with Vicryl™ Rapide (Ethicon) in a rabbit model of intradermic suture and episiotomy.
  
  
  METHODS
  This randomized prospective study was performed on 20 New Zealand rabbits, in which we realized a mediolateral perineo-vaginal incision and two vertical skin incisions of about 8 cm on the abdominal wall. The sutures were randomized between Velosorb™ Fast (Covidien) and Vicryl™ Rapide (Ethicon), and each rabbit was treated with the same suture on both vaginal incision and left abdominal incision, while the right abdominal incision was closed with an alternate suture. A macroscopic examination was performed on days 5 and 11. On day 11, animals were sacrificed for histological (Badylak quantitative score) and electron microscopic examinations. Differences were considered significant at p < .05.
  
  
  RESULTS
  All of the rabbits survived and were included in the final results. Fifty-one sutures were visible by histologic analysis (27 in the Velosorb™ Fast group and 24 in the Vicryl™ Rapide group). The power of the study was ≥80%. There was no significant difference between the two groups based on the total histologic Badylak score analysis or the Badylak sub-score analysis.
  
  
  CONCLUSIONS
  Velosorb™ Fast seems to be as efficient as Vicryl™ Rapide for use in perineal and skin closure.
authors.affiliation: 1Department of Gynecology and Obstetrics, Caremeau University Hospital, Nimes, France.
authors.forename: P
authors.initials: P
authors.lastname: Vieille
authors.forename: S
authors.initials: S
authors.lastname: Huberlant
authors.forename: S
authors.initials: S
authors.lastname: Bastide
authors.forename: Y
authors.initials: Y
authors.lastname: Bayon
authors.forename: R
authors.initials: R
authors.lastname: de Tayrac
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000592:standards; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D004841:Episiotomy / Q000379:methods*; D005260:Female; D023421:Models, Animal; D011098:Polyglactin 910 / Q000592:standards; D011817:Rabbits; D011897:Random Allocation; D012867:Skin / Q000473:pathology; D013526:Surgical Mesh / Q000592:standards; D013537:Sutures / Q000592:standards; D014014:Tissue Adhesives / Q000592:standards; D016896:Treatment Outcome; D014621:Vagina / Q000473:pathology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D014014:Tissue Adhesives; D011098:Polyglactin 910
keywords: animal study; cutaneous suture; episiotomy; perineum; polyglactin 910; rapidly absorbable