title: RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population.
abstract: Recently, a meta-analysis including 5 large genome-wide association studies has identified rs12456492 variant of RIT2 gene as a novel risk locus for Parkinson's disease (PD) in Caucasian populations. However, the association between RIT2 polymorphism and PD risk has not been positively replicated in Asian population yet. We detected the genotypes of rs12456492 in 524 PD patients and 521 control subjects from a Han Chinese population. The allele and genotype distribution of rs12456492 variant were significantly different between PD patients and controls (allele p = 0.001, genotype p = 0.002). Logistic regression analysis showed that the G-carrying genotype (AG + GG) individuals exhibited a nearly 1.4-fold increased risk for PD compared with the AA genotype carriers (OR = 1.390; 95% confidence interval = 1.079-1.791; p = 0.011). Our data support that the carriage of G allele of rs12456492 variant of RIT2 gene significantly increases the risk for PD in Han Chinese population, suggesting a potential role of RIT2 in the etiology of PD.
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Nie
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Feng
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Tang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Gui-xian
authors.initials: GX
authors.lastname: Ma
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Gan
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Jie-hao
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Li-min
authors.initials: LM
authors.lastname: Wang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Zhi-heng
authors.initials: ZH
authors.lastname: Huang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: You-wen
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Rui-ming
authors.initials: RM
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China; Graduate School of Southern Medical University, Guangzhou Guangdong Province, PR China.
authors.forename: Zhen-peng
authors.initials: ZP
authors.lastname: Duan
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China.
authors.forename: Yu-hu
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, PR China. Electronic address: wljgd68@163.com.
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D020559:Monomeric GTP-Binding Proteins; C583559:RiT2 protein, human
keywords: Parkinson's disease; Polymorphism; RIT2; Variant; rs12456492