title: CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection.
abstract: Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.
authors.affiliation: Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: rebecca.vanders@newcastle.edu.au.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Vanders
authors.affiliation: Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: vanessa.murphy@newcastle.edu.au.
authors.forename: Vanessa E
authors.initials: VE
authors.lastname: Murphy
authors.affiliation: Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; The Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia. Electronic address: peter.gibson@hnehealth.nsw.gov.au.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Gibson
authors.affiliation: Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: philip.hansbro@newcastle.edu.au.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Hansbro
authors.affiliation: Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; The Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia. Electronic address: peter.wark@hnehealth.nsw.gov.au.
authors.forename: Peter A B
authors.initials: PA
authors.lastname: Wark
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000276:immunology* / Q000473:pathology; D018811:Maternal Exposure; D051379:Mice; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000473:pathology
keywords: CD8T cells; Dendritic cells (DCs); H1N1pdm09; Infection; Influenza; Pregnancy