title: Enhanced resolution of low molecular weight poly(ethylene glycol) in nanopore analysis.
abstract: A design with conjugation of DNA hairpin structure to the poly(ethylene glycol) molecule was presented to enhance the temporal resolution of low molecular weight poly(ethylene glycol) in nanopore studies. By the virtue of this design, detection of an individual PEG with molecular weight as low as 140 Da was achieved at the single-molecule level in solution, which provides a novel strategy for characterization of an individual small molecule within a nanopore. Furthermore, we found that the current duration time of poly(ethylene glycol) was scaled with the relative molecular weight, which has a potential application in single-molecule detection.
authors.affiliation: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology , Shanghai 200237, P. R. China.
authors.forename: Chan
authors.initials: C
authors.lastname: Cao
authors.forename: Yi-Lun
authors.initials: YL
authors.lastname: Ying
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
mesh_terms: D008954:Models, Biological; D008970:Molecular Weight; D058608:Nanopores; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D011092:Polyethylene Glycols