title: A randomized study comparing the side effects and hormonal status of triptorelin and leuprorelin following conservative laparoscopic surgery for ovarian endometriosis in Chinese women.
abstract: OBJECTIVE
  Different gonadotropin-releasing-hormone agonist (GnRH-a) formulations with different potency and associated side effects, therefore, different compliance and persistence of therapy. This study was to evaluate the difference of hormonal profile and side effects due to hypoestrogenic status after treatment of leuprorelin and triptorelin in Chinese women with ovarian endometrioma after conservative surgical treatment.
  
  
  METHODS
  A total of 302 women underwent laparoscopic excision of ovarian endometriomas with rASRM III and IV were enrolled in the study.Subjects were randomized into two groups with use of a random table. Twenty two patients dropped out during the study. Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment. Menopausal symptoms were evalutaed using a questionnaire and serum sex hormonal levels were also measured during the follow-up.
  
  
  RESULTS
  At week 4 after the treatment, most of the patients in leuprorelin group have no obvious side effects. After 9 weeks, bone pain, hot flashes and sweating, and irregular bleeding were the main side effects and showed no difference between the groups. Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group. A significant difference in FSH (p=0.003), LH (p=0.026) and E2 (p=0.002) levels between the groups were observed after 21 days of the GnRHa treatment. The FSH (p=0.021) and E2 (p=0.033) levels remained higher in the leuprorelin group than the triptorelin group after six weeks of treatment, but the difference of LH(p=0.917) level was no longer discernible.
  
  
  CONCLUSIONS
  Leuprorelin in down-regulating the pituitary-ovarian function was more moderate, and the hormonal levels decrease progressively and gradually, therefore, with lower rate of menopausal symptoms. Leuprorelin acetate maybe better tolerated than triptorelin.
authors.affiliation: Tianjin Central Gynecology and Obstetrics Hospital, 156 San Ma Road, Tianjin 300100, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Tianjin Central Gynecology and Obstetrics Hospital, 156 San Ma Road, Tianjin 300100, China. Electronic address: zhanghongyuan830@hotmail.com.
authors.forename: Hong Yuan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Tianjin Central Gynecology and Obstetrics Hospital, 156 San Ma Road, Tianjin 300100, China.
authors.forename: Ying Jun
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: Tianjin Central Gynecology and Obstetrics Hospital, 156 San Ma Road, Tianjin 300100, China.
authors.forename: Yuan Jing
authors.initials: YJ
authors.lastname: Hu
authors.affiliation: Tianjin Central Gynecology and Obstetrics Hospital, 156 San Ma Road, Tianjin 300100, China.
authors.forename: Peng Peng
authors.initials: PP
authors.lastname: Qu
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D017024:Chemotherapy, Adjuvant; D002681:China; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006727:Hormone Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D006728:Hormones / Q000097:blood*; D006801:Humans; D010535:Laparoscopy; D016729:Leuprolide / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010049:Ovarian Diseases / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D016037:Single-Blind Method; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006727:Hormone Antagonists; D006728:Hormones; D017329:Triptorelin Pamoate; D016729:Leuprolide
keywords: Gonadotropin-releasing hormone; Leuprorelin; Ovary endometriosis; Triptorelin