title: Vaccination of cattle only is sufficient to stop FMDV transmission in mixed populations of sheep and cattle.
abstract: We quantified the transmission of foot-and-mouth disease virus in mixed cattle-sheep populations and the effect of different vaccination strategies. The (partial) reproduction ratios (R) in groups of non-vaccinated and vaccinated cattle and/or sheep were estimated from (published) transmission experiments. A 4 × 4 next-generation matrix (NGM) was constructed using these estimates. The dominant eigenvalue of the NGM, the R for a mixed population, was determined for populations with different proportions of cattle and sheep and for three different vaccination strategies. The higher the proportion of cattle in a mixed cattle-sheep population, the higher the R for the mixed population. Therefore the impact of vaccination of the cattle is higher. After vaccination of all animals R = 0·1 independent of population composition. In mixed cattle-sheep populations with at least 14% of cattle, vaccination of cattle only is sufficient to reduce R to < 1.
authors.affiliation: Central Veterinary Institute (CVI),Wageningen UR,Lelystad,The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Bravo DE Rueda
authors.affiliation: Central Veterinary Institute (CVI),Wageningen UR,Lelystad,The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Dekker
authors.affiliation: Central Veterinary Institute (CVI),Wageningen UR,Lelystad,The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Eblé
authors.affiliation: Department Quantitative Veterinary Epidemiology,Wageningen University,Wageningen,The Netherlands.
authors.forename: M C M
authors.initials: MC
authors.lastname: DE Jong
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D018562:Disease Transmission, Infectious / Q000662:veterinary; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
keywords: Cattle-sheep populations; NGM; foot-and-mouth disease virus; targeted vaccination; transmission