title: Pleiotropic effects of statin in therapy in heart failure: a review.
abstract: Clinical trials demonstrated that statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality when used for either primary or secondary prevention of cardiovascular events. Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent heart failure (HF) in patients with coronary artery disease. This review summarizes the experimental and clinical evidence regarding the role of statins in the management of HF.
authors.forename: Michele
authors.initials: M
authors.lastname: Correale
authors.forename: Silvia
authors.initials: S
authors.lastname: Abruzzese
authors.forename: Carmen A
authors.initials: CA
authors.lastname: Greco
authors.forename: Morena
authors.initials: M
authors.lastname: Concilio
authors.forename: Matteo Di
authors.initials: MD
authors.lastname: Biase
authors.affiliation: Department of Cardiology, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy. nd.brunetti@unifg.it.
authors.forename: Natale D
authors.initials: ND
authors.lastname: Brunetti
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors