title: Efficient synthesis of α- and δ-carbolines by sequential Pd-catalyzed site-selective C-C and twofold C-N coupling reactions.
abstract: Two concise and efficient approaches were developed for the synthesis of α- and δ-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reactions of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with 2-bromophenylboronic acid and subsequent cyclization with amines which proceeds by twofold Pd-catalyzed C-N coupling reactions.
authors.affiliation: Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany. peter.langer@uni-rostock.de.
authors.forename: Tran Quang
authors.initials: TQ
authors.lastname: Hung
authors.forename: Tuan Thanh
authors.initials: TT
authors.lastname: Dang
authors.forename: Julia
authors.initials: J
authors.lastname: Janke
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D008958:Models, Molecular; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D001897:Boronic Acids; D002243:Carbolines; D011725:Pyridines; D010165:Palladium; D002244:Carbon; D009584:Nitrogen