title: Early pregnancy vitamin D and patterns of antenatal inflammation in African-American women.
abstract: Vitamin D is essential for the health of both mother and fetus during pregnancy. In the nonpregnant state, vitamin D demonstrates anti-inflammatory effects, but little is known about this relationship during pregnancy. African-American women are at a higher risk of vitamin D deficiency and for altered inflammatory responses during pregnancy. Therefore, we investigated the association of early pregnancy vitamin D nutrition, as assessed by serum 25-hydroxyvitamin D (25-OHD), with second-trimester inflammatory biomarkers (high-sensitivity C-reactive protein, IL-6, IL-10, IL-1β and TNF-α) in 178 pregnant African-American women. Mean serum 25-OHD was 13.4±8.4 ng/ml, and most women (n=147, 82.6%) had inadequate or deficient levels of 25-OHD (<20 ng/ml). Both serum 25-OHD and some inflammatory cytokines (IL-1β and TNF-α) demonstrated significant seasonal variation. In univariate models, log transformed 25-OHD was significantly and inversely associated with log transformed IL-1β (p=0.002) and log transformed IL-6 (p=0.032). After adjusting for covariates, including seasonality, only the inverse association with IL-1β remained statistically significant (p=0.027). Early pregnancy vitamin D nutrition is associated with some inflammatory biomarkers in mid-pregnancy. Additional studies are needed to determine if low vitamin D nutrition is associated with birth outcomes via an inflammatory-mediated pathway.
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, One Ford Place, Detroit, MI 48202, USA. Electronic address: kbobbit1@hfhs.org.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Bobbitt
authors.affiliation: College of Nursing, Wayne State University, 358 Cohn, Detroit, MI 48202, USA. Electronic address: rpeters@wayne.edu.
authors.forename: Rosalind M
authors.initials: RM
authors.lastname: Peters
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, One Ford Place, Detroit, MI 48202, USA. Electronic address: Jiajiaysc@gmail.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Bone & Mineral Research Laboratory, Henry Ford Hospital, E&R Building 7th Floor, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address: SRAO1@hfhs.org.
authors.forename: Sudhaker D
authors.initials: SD
authors.lastname: Rao
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, One Ford Place, Detroit, MI 48202, USA. Electronic address: kwoodcr1@hfhs.org.
authors.forename: Kimberley J
authors.initials: KJ
authors.lastname: Woodcroft
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, One Ford Place, Detroit, MI 48202, USA. Electronic address: acassid1@hfhs.org.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Cassidy-Bushrow
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000276:immunology; D014808:Vitamin D Deficiency / Q000097:blood / Q000276:immunology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; Inflammation; Pregnancy; Principal components; Vitamin D