title: The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans.
abstract: We evaluated the in vitro and in vivo activities of the investigational arylamidine T-2307 against echinocandin-resistant Candida albicans. T-2307 demonstrated potent in vitro activity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistant C. albicans infections.
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Marcos
authors.initials: M
authors.lastname: Olivo
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Dora I
authors.initials: DI
authors.lastname: McCarthy
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.affiliation: Toyama Chemical Co., Ltd., Toyama, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Fukuda
authors.affiliation: Toyama Chemical Co., Ltd., Toyama, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Mitsuyama
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests
chemical_list: D000578:Amidines; D000935:Antifungal Agents; D054714:Echinocandins; C573060:T-2307