title: Associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults and type 2 diabetes.
abstract: BACKGROUND
  This study aimed to assess the associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults (LADA) and type 2 diabetes.
  
  
  METHODS
  This is a retrospective study. Our diabetes registry included 6975 patients aged 30-75 years old with phenotypic type 2 diabetes who underwent islet autoantibody screening between 2003 and 2012; 384 patients were identified to have LADA. Rates of chronic complications for LADA and type 2 diabetes were compared using a 1 : 2 matched design. Logistic models were fitted to identify the presence of chronic diabetic complications using clinical characteristics including gender, age, duration of diabetes, glycemic control and metabolic syndrome.
  
  
  RESULTS
  When duration of diabetes is <5 years, the prevalence of diabetic nephropathy (nephropathy; 12.2% versus 21.8%, p = 0.018) and diabetic retinopathy (retinopathy; 8.1% versus 15.9%, p = 0.011) were significantly lower in patients with LADA than in patients with type 2 diabetes; the prevalence of nephropathy and retinopathy were comparable between both groups when duration is ≥5 years. There was no significant difference in the prevalence of macrovascular complications between groups. The areas under the receiver operating characteristic curves based on the nephropathy and retinopathy models were larger for LADA than for type 2 diabetes (0.72 versus 0.61, p = 0.013; 0.76 versus 0.68, p = 0.056).
  
  
  CONCLUSIONS
  Patients with LADA had a lower prevalence of microvascular complications than patients with type 2 diabetes when the duration of diabetes was <5 years. Regression equation fitted by clinical characteristics can better predict the risk of microvascular complications in LADA than in type 2 diabetes.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Xuhong
authors.initials: X
authors.lastname: Hou
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Can
authors.initials: C
authors.lastname: Pang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000503:physiopathology; D008875:Middle Aged; D015995:Prevalence; D012372:ROC Curve; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001323:Autoantibodies
keywords: cardiovascular disease; diabetic nephropathy; diabetic retinopathy; latent autoimmune diabetes in adults; type 2 diabetes