title: Spontaneous regression of cutaneous blastic plasmacytoid dendritic cell neoplasm followed by acute monocytic leukemia evolving from myelodysplastic syndrome.
abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy arising from plasmacytoid dendritic cell precursors. BPDCN typically manifests in the skin, but it can also evolve into a leukemic form or be complicated by acute myeloid leukemia, some cases with a preceding myelodysplastic syndrome (MDS). We herein report the first case of complete spontaneous regression of cutaneous BPDCN followed by acute monocytic leukemia evolving from MDS. This is also the first reported case of gastric BPDCN invasion.
authors.affiliation: Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Yasuda
authors.forename: Tomoiku
authors.initials: T
authors.lastname: Takaku
authors.forename: Junichi
authors.initials: J
authors.lastname: Tomomatsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Hosone
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015704:CD4 Antigens; D019002:CD56 Antigen; D003713:Dendritic Cells / Q000473:pathology*; D005756:Gastritis / Q000139:chemically induced / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D015704:CD4 Antigens; D019002:CD56 Antigen