title: [Management of severe or persistent postpartum hemorrhage after vaginal delivery].
abstract: BACKGROUND
  This chapter is an update of the 2004 recommendations for the management of persistent or severe postpartum hemorrhage (PPH) after natural childbirth. Severe PPH is defined by estimated blood loss greater than 1000mL (gradeC). Persistent bleeding within 15 to 30minutes after diagnosis and initial treatment (gradeC) or abundant immediately (professional consensus) should lead to a further management.
  
  
  METHODS
  A systematic review of the literature concerning the management of persistent or severe PPH was conducted on Medline and Cochrane Database, with no specified time period.
  
  
  CONCLUSIONS
  The initial clinical evaluation is the same whatever initial severity. Each possible cause of bleeding must be evaluated: uterine vacuity must be checked and birth canal lesions must be researched and repaired (gradeC). Sulprostone is effective for the treatment of severe or persistent PPH (EL4) and its use is recommended for the management of PPH resistant to oxytocin administration (grade B). In the current state of the literature, there is no argument for replacing sulprostone in France by dinoprostone or prostaglandins F2α (professional consensus). If oxytocin has been administered, it is not recommended to use misoprostol (EL1) as adjuvant treatment because there is no evidence of benefit in this indication (grade A). Balloon intra-uterine tamponade appears to be an efficient mechanical treatment of uterine atony in case of failure of the initial management by sulprostone. Tamponade allows avoiding the need for further interventional radiology or surgery in most cases (EL4). Intra-uterine tamponade may be offered in case of failure of sulprostone and prior to surgical management or interventional radiology (professional consensus). Its use is left to the discretion of the practitioner. Tamponade should not delay the implementation of further invasive procedures.
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France. Electronic address: o.morel@maternite.chu-nancy.fr.
authors.forename: O
authors.initials: O
authors.lastname: Morel
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: E
authors.initials: E
authors.lastname: Perdriolle-Galet
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Mézan de Malartic
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: E
authors.initials: E
authors.lastname: Gauchotte
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Moncollin
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Patte
authors.affiliation: Service d'obstétrique et de médecine fœtale, pôle de gynécologie-obstétrique, université de Lorraine, CHU de Nancy, 10, rue Heydenreich, 54000 Nancy, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Chabot-Lecoanet
mesh_terms: D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D017410:Practice Guidelines as Topic / Q000592:standards*; D058738:Uterine Balloon Tamponade / Q000592:standards*
keywords: Hémorragie du post-partum; Misoprostol; Oxytocin; Oxytocine; Postpartum haemorrhage; Prostaglandines; Prostaglandins; Sulprostone; Tamponnement utérin; Uterine tamponade