title: Variation in SLC1A1 is related to combat-related posttraumatic stress disorder.
abstract: Candidate gene studies have yet to investigate the glutamate system, the primary excitatory neurotransmitter of the HPA-axis related to PTSD risk. We investigated 13 SNPs in the glutamate transporter gene (SLC1A1) in relation to PTSD among combat-exposed veterans. Participants (n=418) completed a diagnostic interview and provided a blood sample for DNA isolation and genotyping. A subset of participants (n=391) had severity and combat exposure data available. In the primary logistic regression gender and rs10739062 were significant predictors of PTSD diagnosis (OR=0.50; OR=1.43). In the linear regression analysis, combat exposure was the only significant predictor (β=0.16) of severity. A computed genetic risk sum score was significant in relation to PTSD diagnosis (OR=1.15) and severity scores (β=0.14) above and beyond the effects of combat exposure. This study provides preliminary support for the relationship of glutamate transporter polymorphisms to PTSD risk and the need for further genetic studies within this system.
authors.affiliation: Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: McGuire VA Medical Center, Richmond, VA, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Sheerin
authors.affiliation: Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Mandel
authors.affiliation: Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD, USA.
authors.forename: Anne N
authors.initials: AN
authors.lastname: Banducci
authors.affiliation: Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
authors.forename: Hugh
authors.initials: H
authors.lastname: Myrick
authors.affiliation: Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Acierno
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Ananda B
authors.initials: AB
authors.lastname: Amstadter
authors.affiliation: Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA. Electronic address: wanzh@musc.edu.
authors.forename: Zhewu
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D003130:Combat Disorders / Q000235:genetics*; D050580:Excitatory Amino Acid Transporter 3 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics*; D014728:Veterans
chemical_list: D050580:Excitatory Amino Acid Transporter 3; C493400:SLC1A1 protein, human
keywords: Combat stress disorders; Genes; Posttraumatic stress disorder; SLC1A1; Veterans