title: Self-reported affective traits and current affective experiences of biological relatives of people with schizophrenia.
abstract: Schizophrenia is characterized by self-reported trait anhedonia but intact hedonic responses during laboratory experiments. Affective traits of first-degree biological relatives may be similar to those of people with schizophrenia, and measures of hedonic response in relatives may be free of antipsychotic medication or cognitive confounds. Relatives also self-report increased anhedonia, yet it is unclear whether, like in patients, this anhedonia is paired with largely intact hedonic self-report. In this study, first-degree relatives of people with schizophrenia (n=33) and nonpsychiatric controls (n=25) completed a wide range of questionnaires and tasks assessing social and physical anhedonia, positive and negative affective experience, and anticipatory and consummatory pleasure. Valence, intensity, frequency, and the arousal of current emotion were assessed. Extraversion and current positive and negative affective state were also examined in relation to self-reported social anhedonia. Relatives evidenced the same disjunction of increased self-reported anhedonia and intact affective response observed in people with schizophrenia. Group differences in anhedonia were not better accounted for by decreased current positive affect, increased current negative affect, or decreased extraversion in relatives. Results suggest that, like people with schizophrenia, first-degree relatives report intact hedonic response on both questionnaire and laboratory measures despite significant elevations in self-reported social anhedonia.
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23220, USA. Electronic address: ardocherty@vcu.edu.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Docherty
authors.affiliation: Psychology Service, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN 55417, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Sponheim
authors.affiliation: Department of Psychology, University of Missouri - Columbia, Columbia, MO 65201, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Kerns
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D000368:Aged; D059445:Anhedonia; D004644:Emotions; D005120:Extraversion, Psychological; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Affect; Anhedonia; Emotion; Genetic; Relatives; Schizotypal