title: Ternary system based on fluorophore-surfactant assemblies--Cu²⁺ for highly sensitive and selective detection of arginine in aqueous solution.
abstract: A new cationic dansyl derivative-based (DIlSD) fluorescence probe was designed and synthesized. Its combination with anionic surfactant SDS assemblies shows enhanced fluorescence intensity and blue-shifted maximum wavelength. Its fluorescence can be slightly quenched by Cu(2+); however, the fluorescence quenching efficiency by Cu(2+) is highly increased upon titration of arginine (Arg). As a result, the ternary system containing the cationic fluorophore, anionic surfactant, and Cu(2+) functions as a highly sensitive and selective sensor to Arg. The optimized sensor system displays a detection limit of 170 nM, representing the highest sensitivity to Arg in total aqueous solution by a fluorescent sensor. Control experiments reveal that the imidazolium groups in the fluorophore, the anionic surfactant, and Cu(2+) all play important roles in the process of sensing Arg. The electrostatic interaction between the cationic fluorophore and anionic surfactants facilitates the binding of imidazolium rings with Cu(2+), the surfactant surface-anchored Cu(2+) is responsible for further binding of Arg, and the electrostatic interaction between anionic surfactants and positively charged amino acids accounts for the selective responses to Arg.
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University , Xi'an 710062, P. R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cao
authors.forename: Liping
authors.initials: L
authors.lastname: Ding
authors.forename: Wenting
authors.initials: W
authors.lastname: Hu
authors.forename: Xiangli
authors.initials: X
authors.lastname: Chen
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
mesh_terms: D001120:Arginine / Q000032:analysis* / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D003300:Copper / Q000737:chemistry*; D003619:Dansyl Compounds / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry; D057230:Limit of Detection; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012996:Solutions; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D007093:Imidazoles; D012996:Solutions; D013501:Surface-Active Agents; D014867:Water; D012967:Sodium Dodecyl Sulfate; D003300:Copper; C029899:imidazole; D001120:Arginine