title: Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.
abstract: Benzofuran heterocycles are fundamental structural units in a variety of biologically active natural products as well as synthetic materials. Over the time, benzofuran derivatives have attracted many researchers due to the broad scope of their biological activity, which include anticancer, antimicrobial, immunomodulatory, antioxidant and anti-inflammatory properties. Egonol, homoegonol and moracin families are biologically active natural products containing benzofuran heterocycle as basic structural units. This paper focuses on the moracin family (moracin A to Z). Morus, a genus of flowering plants in the family Moraceae, comprises 10-16 species of deciduous trees commonly known as mulberries. The root bark, stem bark and leaves of Morus alba, M. lhou, Morus macroura are the main sources for arylbenzofuran derivatives including the moracins. A large volume of research has been carried out on moracins and their derivatives, which has shown the pharmacological importance of this benzofuran heterocyclic nucleus. In this mini-review, we attempt to highlight the importance of moracins, as they have been a major source for drug development. Herein, we also summarize the current state of the art concerning the synthesis and medicinal use of moracins A-Z.
authors.affiliation: BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, Goyang 410-820, Republic of Korea.
authors.forename: Ravi
authors.initials: R
authors.lastname: Naik
authors.affiliation: BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, Goyang 410-820, Republic of Korea.
authors.forename: Dipesh S
authors.initials: DS
authors.lastname: Harmalkar
authors.affiliation: BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, Goyang 410-820, Republic of Korea.
authors.forename: Xuezhen
authors.initials: X
authors.lastname: Xu
authors.affiliation: BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, Goyang 410-820, Republic of Korea.
authors.forename: Kyusic
authors.initials: K
authors.lastname: Jang
authors.affiliation: BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, Goyang 410-820, Republic of Korea. Electronic address: kaylee@dongguk.edu.
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000975:Antioxidants; D001572:Benzofurans; D007155:Immunologic Factors; C105430:benzofuran
keywords: Benzofuran; Biological activity; Moracins; Mulberries