title: Design, synthesis and structure--activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents.
abstract: Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR cancer cell lines. Regio-isomeric imidazo[4,5-b]pyridine analogues were synthesized and evaluated for their cytotoxic activity against a range of cancer cell lines. The structure-activity relationship (SAR) studies of the imidazopyridine analogues are also described. Analogue 6b displayed strong cytotoxicity and good microsomal stability.
authors.affiliation: Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India. Electronic address: sajith.chem@gmail.com.
authors.forename: Ayyiliath M
authors.initials: AM
authors.lastname: Sajith
authors.affiliation: Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Abdul Khader
authors.affiliation: Department of Biosciences and Bioengineering, IIT Mumbai, India.
authors.forename: Nithin
authors.initials: N
authors.lastname: Joshi
authors.affiliation: Central University of Kerala, Vidyanagar, Kasaragod, Periya, Kerala, India.
authors.forename: Manchala Nageswar
authors.initials: MN
authors.lastname: Reddy
authors.affiliation: Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India.
authors.forename: M
authors.initials: M
authors.lastname: Syed Ali Padusha
authors.affiliation: Research Center, Department of Chemistry, East West Institute of Technology, Bangalore, India.
authors.forename: H P
authors.initials: HP
authors.lastname: Nagaswarupa
authors.affiliation: Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Nibin Joy
authors.affiliation: Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, India.
authors.forename: Yadav D
authors.initials: YD
authors.lastname: Bodke
authors.affiliation: School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. Kannur, Kerala, India.
authors.forename: Ranjith P
authors.initials: RP
authors.lastname: Karuvalam
authors.affiliation: Department of Biosciences and Bioengineering, IIT Mumbai, India.
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India.
authors.forename: A
authors.initials: A
authors.lastname: Muralidharan
authors.affiliation: Central University of Kerala, Vidyanagar, Kasaragod, Periya, Kerala, India.
authors.forename: P
authors.initials: P
authors.lastname: Rajendra
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D011687:Purines; D011725:Pyridines; C000600672:imidazo(4,5-b)pyridine
keywords: Chemotherapy; Cytotoxic studies; Imidazo[4,5-b]pyridine analogues; Suzuki coupling