title: Microfluidics-to-mass spectrometry: a review of coupling methods and applications.
abstract: Microfluidic devices offer great advantages in integrating sample processes, minimizing sample and reagent volumes, and increasing analysis speed, while mass spectrometry detection provides high information content, is sensitive, and can be used in quantitative analyses. The coupling of microfluidic devices to mass spectrometers is becoming more common with the strengths of both systems being combined to analyze precious and complex samples. This review summarizes select achievements published between 2010 and July 2014 in novel coupling between microfluidic devices and mass spectrometers. The review is subdivided by the types of ionization sources employed, and the different microfluidic systems used.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
authors.forename: Lian
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
authors.forename: Nikita
authors.initials: N
authors.lastname: Mukhitov
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Schrell
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
authors.forename: Raghuram
authors.initials: R
authors.lastname: Dhumpa
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA. Electronic address: roper@chem.fsu.edu.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Roper
mesh_terms: D013058:Mass Spectrometry / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000295:instrumentation*
keywords: Bioanalysis; Integrated devices; Lab-on-a-chip; Metabolomics; Proteomics