title: Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents.
abstract: Type 2 diabetes (T2D) is a lifestyle disease affecting millions of people worldwide. Various therapies are available for the management of T2D and dipeptidyl peptidase-IV (DPP-IV) inhibition has emerged as a promising therapy for the treatment of type 2 diabetes (T2D). Here we report design, synthesis and in vitro efficacy of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents. Amongst all the compounds synthesized in this series, 9a, is the most potent (IC50 = 41.17 nM).
authors.affiliation: Department of Chemistry, Faculty of Science, The M. S. University of Baroda, Vadodara, Gujarat 390 002, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, Faculty of Science, The M. S. University of Baroda, Vadodara, Gujarat 390 002, India. Electronic address: shubhangiss@rediffmail.com.
authors.forename: Shubhangi S
authors.initials: SS
authors.lastname: Soman
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D010880:Piperidines; D011759:Pyrrolidines; D013449:Sulfonamides; C032727:piperidine; C032519:pyrrolidine
keywords: Anti-diabetic agents; Sulfonamide derivatives of pyrrolidine and piperidine; Type 2 diabetes