title: Pathophysiological mechanisms regulated by cytokines in gliomas.
abstract: Glioma, a neuroglia originated malignancy, consists of one of the most aggressive primary tumors of the central nervous system with poor prognosis and lack of efficient treatment strategy. Cytokines have been implicated in several stages of glioma progression, participating in tumor onset, growth enhancement, angiogenesis and aggressiveness. Interestingly, cytokines have also the ability to inhibit glioma growth upon specific regulation or interplay with other molecules. This review addresses the dual role of major cytokines implicated in glioma pathology, pointing toward promising therapeutic approaches.
authors.affiliation: Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece.
authors.forename: Anthos
authors.initials: A
authors.lastname: Christofides
authors.affiliation: Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece.
authors.forename: Marinos
authors.initials: M
authors.lastname: Kosmopoulos
authors.affiliation: Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece. Electronic address: cpiperi@med.uoa.gr.
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
mesh_terms: D000818:Animals; D017209:Apoptosis; D015415:Biomarkers / Q000378:metabolism; D001932:Brain Neoplasms / Q000503:physiopathology*; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy / Q000379:methods; D005910:Glioma / Q000503:physiopathology*; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D017628:Microglia / Q000473:pathology; D009389:Neovascularization, Pathologic; D011379:Prognosis; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D020382:Interleukin-18; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D016212:Transforming Growth Factor beta
keywords: Cytokines; Glioma; IL-18; TGF-β; TNF