title: Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
abstract: Ubiquitin-specific peptidase 22 (USP22) was recently identified as a new tumor cell marker, and previous studies demonstrated its expression in a variety of tumors and its correlation with tumor progression. Because tumor progression plays an important role in cancer, researchers are paying more attention to the correlation between USP22 expression and metastatic potential, resistance to chemotherapy, and patient prognosis. This study showed that USP22 is highly expressed in gastric cancer tissues, and significant differences in USP22 expression (P < 0.01) were identified between different types of gastric cancer (the highest expression was found in poorly differentiated adenocarcinomas). In addition USP22 expression was found to be correlated with the promotion of cancer evolution, tumor invasion, and lymph node metastasis. The C-myc protein was also shown to have synergistic effects with USP22 in gastric cancer tissue. On the basis of the results, USP22 expression may play an important role in gastric carcinoma tissue, particularly in precancerous lesions during the gastric cancer evolution process.
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Yin-Ji
authors.initials: YJ
authors.lastname: Jin
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Hong-Xue
authors.initials: HX
authors.lastname: Meng
authors.affiliation: Department of Pathology, Harbin Medical University (Daqing), Daqing, China.
authors.forename: Bao-Shan
authors.initials: BS
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Forensic Medicine, Harbin Medical University, Harbin, China.
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Guan-Ying
authors.initials: GY
authors.lastname: Liang
authors.affiliation: Department of Gynecology, Third Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 15395030@qq.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Kong
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China. Electronic address: jinxm55@126.com.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Jin
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology*; D013869:Thiolester Hydrolases / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; C527170:Usp22 protein, human