title: Derivation and validation of the SEER-Medicare myelodysplastic syndromes risk score (SMMRS).
abstract: Accruing data since 2001, the SEER-Medicare dataset is an outstanding resource for MDS-related comparative effectiveness research; however, although several MDS prognostic models exist, complete data required to calculate them are not available therein. Using SEER-Medicare as a training and internal validation set (n=9820) and clinical data at our institution as an external validation set (n=307), we created a new MDS risk score (the SMMRS) for use with SEER-Medicare. Risk stratification by the SMMRS was comparable to the IPSS (net reclassification improvement index was 0.0), demonstrating that it is a useful research tool to stratify MDS patients in studies using SEER-Medicare.
authors.affiliation: Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Hajime
authors.initials: H
authors.lastname: Uno
authors.affiliation: Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Cronin
authors.affiliation: Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.affiliation: Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Schrag
authors.affiliation: Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: gregory_abel@dfci.harvard.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Abel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D006278:Medicare; D008875:Middle Aged; D008954:Models, Biological; D009190:Myelodysplastic Syndromes; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States
keywords: Comparative effectiveness; MDS; Prognosis; SEER; SEER-Medicare