title: A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities.
abstract: A rare type of sesquiterpene with a spiro bicyclic system (1) and seven new (2-8) and four known (9-12) β-santalol derivatives were isolated from the heartwood of Santalum album (Santalaceae). The structures of these new compounds were determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, HSC-2 and HSC-4 human oral squamous cell carcinoma cell lines, and TIG-3 normal human diploid fibroblasts. cis-β-Santalol (9) and β-santaldiol (10) induced apoptotic cell death in HL-60 cells.
authors.affiliation: Tokyo University of Pharmacy and Life Sciences, School of Pharmacy.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D000081223:Polycyclic Sesquiterpenes; D032123:Santalum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D014934:Wood / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C043206:santalol; D053148:Caspase 3