title: Modelling of FDG metabolism in liver voxels.
abstract: Kinetic analysis is a tool used to glean additional information from positron emission tomography (PET) data by exploiting the dynamics of tissue metabolism. The standard irreversible and reversible two compartment models used in kinetic analysis were initially developed to analyse brain PET data. The application of kinetic analysis to PET of the liver presents the opportunity to move beyond the generic standard models and develop physiologically informed pharmacokinetic models that incorporate structural and functional features in particular to the liver. In this paper, we develop a new compartment model, called the tubes model, which is informed by the liver׳s sinusoidal architecture, high fractional blood volume, high perfusion rate, and large hepatocyte surface area facing the space of Disse. The tubes model distributes tracer between the blood and intracellular compartments in more physiologically faithful proportions than the standard model, producing parametric images with improved contrast between healthy and neoplastic tissue.
authors.affiliation: The Australian e-Health Research Centre, Royal Brisbane and Women׳s Hospital, Herston, 4029 Queensland, Australia; School of Medicine, The University of Queensland, 288 Herston Road, Herston, 4006 Queensland, Australia. Electronic address: Charles.Baker@csiro.au.
authors.forename: C
authors.initials: C
authors.lastname: Baker
authors.affiliation: The Australian e-Health Research Centre, Royal Brisbane and Women׳s Hospital, Herston, 4029 Queensland, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Dowson
authors.affiliation: School of Medicine, The University of Queensland, 288 Herston Road, Herston, 4006 Queensland, Australia; Specialised PET Services, Nuclear Medicine Department, Royal Brisbane and Women׳s Hospital, Herston, 4029 Queensland, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.affiliation: The Australian e-Health Research Centre, Royal Brisbane and Women׳s Hospital, Herston, 4029 Queensland, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Rose
mesh_terms: D001810:Blood Volume; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging*; D008954:Models, Biological; D049268:Positron-Emission Tomography; D012015:Reference Standards; D013154:Spleen / Q000000981:diagnostic imaging; D013997:Time Factors
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Compartment modelling; Kinetic analysis; Mathematical liver physiology; Parametric imaging; Positron emission tomography