title: New insights into the autotaxin/LPA axis in cancer development and metastasis.
abstract: Lysophosphatidic acid (LPA) is a simple lipid with a single fatty acyl chain linked to a glycerophosphate backbone. Despite the simplicity of its structure but owing to its interactions with a series of at least six G protein-coupled receptors (LPA1-6), LPA exerts pleiotropic bioactivities including stimulation of proliferation, migration and survival of many cell types. Autotaxin (ATX) is a unique enzyme with a lysophospholipase D (lysoPLD) activity that is responsible for the levels of LPA in the blood circulation. Both LPA receptor family members and ATX/LysoPLD are aberrantly expressed in many human cancers. This review will present the more striking as well as novel experimental evidences using cell lines, cancer mouse models and transgenic animals identifying the roles for ATX and LPA receptors in cancer progression, tumor cell invasion and metastasis.
authors.affiliation: INSERM, UMR1033, UCB Lyon 1, Faculté de Médecine Lyon Est, Lyon, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Leblanc
authors.affiliation: INSERM, UMR1033, UCB Lyon 1, Faculté de Médecine Lyon Est, Lyon, France. Electronic address: olivier.peyruchaud@inserm.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Peyruchaud
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism* / Q000556:secondary; D063646:Carcinogenesis / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000502:physiology*; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism; D015398:Signal Transduction; D000099189:Lysophospholipase D
chemical_list: D008246:Lysophospholipids; D010727:Phosphoric Diester Hydrolases; D049368:Receptors, Lysophosphatidic Acid; D000099189:Lysophospholipase D; C032881:lysophosphatidic acid
keywords: ATX; Autotaxin; LPA; LysoPLD; Lysophosphatidic acid; cancer; metastasis