title: Mortality in women with pregnancy-associated malignant melanoma.
abstract: BACKGROUND
  Malignant melanoma (MM) is one of the most common malignancies in young women. It remains debated whether a MM diagnosed during pregnancy or lactation has a worse prognosis.
  
  
  OBJECTIVE
  We sought to examine mortality in women with pregnancy-associated MM (PAMM) (diagnosed during pregnancy and up to 2-years postpartum).
  
  
  METHODS
  This was a population-based cohort study based on information retrieved from the Swedish Cancer and Multi-Generation Registers. Hazard ratios with 95% confidence intervals adjusted for age, period, education, parity, and tumor location were estimated.
  
  
  RESULTS
  In total, 6857 women and girls aged 15 to 44 years with a diagnosis of cutaneous MM between 1963 and 2009 were identified. Of these, 1019 cases were classified as PAMM. The cause-specific mortality did not differ between PAMM and MM not diagnosed near childbirth (adjusted hazard ratio 1.09, 95% confidence interval 0.83-1.42).
  
  
  CONCLUSIONS
  Information on stage at diagnosis was available only for a subset of patients
  
  
  CONCLUSIONS
  Overall, the cause-specific mortality in women and girls with PAMM did not differ from that in women and girls with non-PAMM. The current findings do not provide evidence of an adverse prognostic influence of pregnancy or a recent birth.
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: anna.johansson@ki.se.
authors.forename: Anna L V
authors.initials: AL
authors.lastname: Johansson
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Therese M-L
authors.initials: TM
authors.lastname: Andersson
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Plym
authors.affiliation: Department of Radiology, Oncology, and Radiation Science, Section of Oncology, Uppsala University, Uppsala, Sweden.
authors.forename: Gustav J
authors.initials: GJ
authors.lastname: Ullenhag
authors.affiliation: Cancer Epidemiology and Population Health, King's College London, London, United Kingdom.
authors.forename: Henrik
authors.initials: H
authors.lastname: Møller
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Regional Cancer Center, Uppsala, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Lambe
mesh_terms: D000293:Adolescent; D000328:Adult; D003644:Death Certificates; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008545:Melanoma / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries / Q000706:statistics & numerical data; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
keywords: Sweden; malignant melanoma; mortality; pregnancy; stage; survival