title: Effect of Yeonryeonggobon-dan (YRGBD), an herbal complex, on glycemic control in patients with Type 2 diabetes mellitus: a case series.
abstract: BACKGROUND
  Diabetes mellitus has significant effects on the human body. Recently, herbal medicines have received attention as complementary anti-diabetic agents on the basis of the results of several experimental studies. We present a series of 38 cases that demonstrate the positive effect of Yeonryeonggobon-dan (YRGBD), an herbal complex, in lowering blood sugar levels in patients with uncontrolled type 2 diabetes mellitus.
  
  
  METHODS
  We reviewed the medical records of 38 patients treated with YRGBD. The types and doses of other hypoglycemic agents administered to the patients remained unchanged during treatment with YRGBD.
  
  
  RESULTS
  After YRGBD therapy, the glycated haemoglobin level decreased from 76.16±19.90mmol/mol (9.11±1.82%) to 51.21±8.82mmol/mol (6.84±0.81%). There was a statistically significant difference between the glycated haemoglobin levels measured before and after treatment (paired t test, p<0.001).
  
  
  CONCLUSIONS
  In the present study, we show the clinical effects of YRGBD on blood sugar control in patients with type 2 diabetes mellitus. Further clinical studies investigating the effects of YRGBD are needed.
authors.affiliation: Kyunghee-saeng Korean Medicine Clinic, Seoul, Republic of Korea.
authors.forename: Jiman
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
authors.forename: A Ri
authors.initials: AR
authors.lastname: Byun
authors.affiliation: Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, KyungHee University, Seoul, Republic of Korea. Electronic address: kkokkottung@hanmail.net.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Kwon
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D004365:Drugs, Chinese Herbal; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents
keywords: Diabetes mellitus; Glycemic control; Herbal medicine; Type 2 diabetes; YRGBD; Yeonryeonggobon-dan