title: Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.
abstract: Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, and ∥Research Institute of Oceanography, Seoul National University , NS-80, 151-747, Seoul, Republic of Korea.
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Patil
authors.forename: Sinwoo
authors.initials: S
authors.lastname: Kang
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Min-Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D056910:Republic of Korea; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D013844:Thiazoles; C000595539:anithiactin A; C000595540:anithiactin B; C000595541:anithiactin C