title: Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-α(1, 3)-galactose (α-gal) as antigenic determinant.
abstract: Specific immunoglobulin E (sIgE) antibodies towards the galactose-α(1,3)-galactose (α-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to α-gal moieties from mammalian meat may also react towards mammalian gelatins and gelatin-containing drugs such as bovine gelatin-based colloid plasma substitute. The case of a 56 year old woman with a meat allergy who suffered anaphylaxis to succinylated gelatin is reported.
authors.affiliation: Faculty of Medicine, Department of Immunology, Allergology, Rheumatology, University of Antwerp, 2610 Antwerp, Belgium; Department of Immunology, Allergology, Rheumatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Uyttebroek
authors.affiliation: Faculty of Medicine, Department of Immunology, Allergology, Rheumatology, University of Antwerp, 2610 Antwerp, Belgium; Department of Immunology, Allergology, Rheumatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Sabato
authors.affiliation: Department of Immunology, Allergology, Rheumatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
authors.forename: C H
authors.initials: CH
authors.lastname: Bridts
authors.affiliation: Faculty of Medicine, Department of Immunology, Allergology, Rheumatology, University of Antwerp, 2610 Antwerp, Belgium; Department of Immunology, Allergology, Rheumatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
authors.forename: L S
authors.initials: LS
authors.lastname: De Clerck
authors.affiliation: Faculty of Medicine, Department of Immunology, Allergology, Rheumatology, University of Antwerp, 2610 Antwerp, Belgium; Department of Immunology, Allergology, Rheumatology, Antwerp University Hospital, 2650 Antwerp, Belgium. Electronic address: immuno@ua.ac.be.
authors.forename: D G
authors.initials: DG
authors.lastname: Ebo
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D004187:Disaccharides / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D012882:Skin Tests; D013386:Succinates / Q000009:adverse effects*
chemical_list: D004187:Disaccharides; D000939:Epitopes; D013386:Succinates; C055075:galactosyl-(1-3)galactose; D007073:Immunoglobulin E; C060085:succinylated gelatin; D005780:Gelatin
keywords: Gelatin allergy; Perioperative anaphylaxis; α-gal allergy