title: Vanishing bile duct syndrome and immunodeficiency preceding the diagnosis of Hodgkin lymphoma.
abstract: Vanishing bile duct syndrome (VBDS) in association with Hodgkin lymphoma (HL) is well described but not well understood. We report an unusual case of a 75-year-old patient presenting with biopsy-proven VBDS and immunodeficiency, without identifiable cause, which showed a waxing and waning course, culminating in the development of HL 18 months later. To our knowledge, this is the first adult case in which VBDS preceded the diagnosis of HL by such a long period.
authors.affiliation: Department of Haematopathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Yeh
authors.forename: J
authors.initials: J
authors.lastname: Lokan
authors.forename: A
authors.initials: A
authors.lastname: Anantharajah
authors.forename: A
authors.initials: A
authors.lastname: Grigg
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D001761:Bleomycin / Q000008:administration & dosage; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D002779:Cholestasis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D004317:Doxorubicin / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009503:Neutropenia; D013577:Syndrome; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
chemical_list: D002756:Cholagogues and Choleretics; D001761:Bleomycin; D014580:Ursodeoxycholic Acid; D004317:Doxorubicin
keywords: Hodgkin lymphoma; immunodeficiency; ursodeoxycholic acid; vanishing bile duct syndrome