title: c-Fos induction in mesotelencephalic dopamine pathway projection targets and dorsal striatum following oral intake of sugars and fats in rats.
abstract: Overconsumption of nutrients high in fats and sugars can lead to obesity. Previous studies indicate that sugar or fat consumption activate individual brain sites using Fos-like immunoreactivity (FLI). Sugars and fats also elicit conditioned flavor preferences (CFP) that are differentially mediated by flavor-flavor (orosensory: f/f) and flavor-nutrient (post-ingestive: f/n) processes. Dopamine (DA) signaling in the medial prefrontal cortex (mPFC), the amygdala (AMY) and the nucleus accumbens (NAc), has been implicated in acquisition and expression of fat- and sugar-CFP. The present study examined the effects of acute consumption of fat (corn oil: f/f and f/n), glucose (f/f and f/n), fructose, (f/f only), saccharin, xanthan gum or water upon simultaneous FLI activation of DA mesotelencephalic nuclei (ventral tegmental area (VTA)) and projections (infralimbic and prelimbic mPFC, basolateral and central-cortico-medial AMY, core and shell of NAc as well as the dorsal striatum). Consumption of corn oil solutions, isocaloric to glucose and fructose, significantly increased FLI in all sites except for the NAc shell. Glucose intake significantly increased FLI in both AMY areas, dorsal striatum and NAc core, but not in either mPFC area, VTA or Nac shell. Correspondingly, fructose intake significantly increased FLI in the both AMY areas, the infralimbic mPFC and dorsal striatum, but not the prelimbic mPFC, VTA or either NAc area. Saccharin and xanthan gum intake failed to activate FLI relative to water. When significant FLI activation occurred, highly positive relationships were observed among sites, supporting the idea of activation of a distributed brain network mediating sugar and fat intake.
authors.affiliation: Neuropsychology Doctoral Sub-Program, The Graduate Center, City University of New York, USA; School of Mental Health and Neuroscience, Maastricht University, USA.
authors.forename: J A D
authors.initials: JA
authors.lastname: Dela Cruz
authors.affiliation: Department of Psychology, Queens College, City University of New York, USA.
authors.forename: T
authors.initials: T
authors.lastname: Coke
authors.affiliation: Department of Psychology, Queens College, City University of New York, USA.
authors.forename: T
authors.initials: T
authors.lastname: Karagiorgis
authors.affiliation: Department of Psychology, Queens College, City University of New York, USA.
authors.forename: C
authors.initials: C
authors.lastname: Sampson
authors.affiliation: Department of Psychology, Queens College, City University of New York, USA.
authors.forename: D
authors.initials: D
authors.lastname: Icaza-Cukali
authors.affiliation: Neuropsychology Doctoral Sub-Program, The Graduate Center, City University of New York, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kest
authors.affiliation: Neuropsychology Doctoral Sub-Program, The Graduate Center, City University of New York, USA; Department of Psychology, Queens College, City University of New York, USA.
authors.forename: R
authors.initials: R
authors.lastname: Ranaldi
authors.affiliation: Neuropsychology Doctoral Sub-Program, The Graduate Center, City University of New York, USA; Department of Psychology, Queens College, City University of New York, USA. Electronic address: Richard.Bodnar@qc.cuny.edu.
authors.forename: R J
authors.initials: RJ
authors.lastname: Bodnar
mesh_terms: D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003314:Corn Oil / Q000008:administration & dosage; D059290:Dopaminergic Neurons / Q000378:metabolism*; D004435:Eating; D005632:Fructose / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D017072:Neostriatum / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D017397:Prefrontal Cortex / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin / Q000008:administration & dosage; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D017557:Ventral Tegmental Area / Q000378:metabolism; D014867:Water / Q000008:administration & dosage
chemical_list: D011135:Polysaccharides, Bacterial; D016760:Proto-Oncogene Proteins c-fos; D014867:Water; D005632:Fructose; D003314:Corn Oil; D014446:Tyrosine 3-Monooxygenase; D012439:Saccharin; D005947:Glucose; C002563:xanthan gum
keywords: Basolateral amygdala; Central-cortico-medial amygdala; Dorsal striatum; Infralimbic medial prefrontal cortex; Nucleus accumbens core; Nucleus accumbens shell; Prelimbic medial prefrontal cortex; Ventral tegmental area