title: Determination of 2-methoxyestradiol by chemiluminescence based on luminol-KMnO4-CdTe quantum dots system.
abstract: In this study, water-soluble CdTe quantum-dots (QDs) capped with glutathione (GSH) was synthesized. It was found that CdTe QDs could greatly enhance the chemiluminescence (CL) emission from the luminol-KMnO4 system in alkaline medium, and 4 nm CdTe QDs was used as catalysts to enhance the reaction sensitivity. The CL intensity of CdTe QDs-luminol-KMnO4 was strongly inhibited in the presence of 2-methoxyestradiol (2-ME) and the relative CL intensity was in linear correlation with the concentration of 2-ME. Based on this inhibition, a novel CL method with a lower detection limit and wider linear range was developed for the determination of 2-ME. The detection limit of plasma samples was 3.07×10(-10) g mL(-1) with a relative standard deviation of 0.24% for 8.0×10(-9) g mL(-1) 2-ME. The method was successfully applied for determination of 2-ME in plasma samples. The possible CL reaction mechanism was also discussed briefly.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Du
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Han
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Cao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Qu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China. Electronic address: xhgpaper@sina.com.
authors.forename: Xinhong
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Science Road 100, Zhengzhou 450001, PR China.
authors.forename: Hanchun
authors.initials: H
authors.lastname: Yao
mesh_terms: D000077584:2-Methoxyestradiol; D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry; D007700:Kinetics; D008163:Luminescent Measurements / Q000379:methods*; D008165:Luminol / Q000737:chemistry*; D051379:Mice; D011196:Potassium Permanganate / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D011196:Potassium Permanganate; D004958:Estradiol; D008165:Luminol; D000077584:2-Methoxyestradiol; D013691:Tellurium; C028337:cadmium telluride
keywords: 2-Methoxyestradiol; CdTe quantum-dots; Chemiluminescence; Flow injection