title: Magnetic particle imaging with tailored iron oxide nanoparticle tracers.
abstract: Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2(∗) -weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
authors.forename: R Matthew
authors.initials: RM
authors.lastname: Ferguson
authors.forename: Amit P
authors.initials: AP
authors.lastname: Khandhar
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Kemp
authors.forename: Hamed
authors.initials: H
authors.lastname: Arami
authors.forename: Emine U
authors.initials: EU
authors.lastname: Saritas
authors.forename: Laura R
authors.initials: LR
authors.lastname: Croft
authors.forename: Justin
authors.initials: J
authors.lastname: Konkle
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Goodwill
authors.forename: Aleksi
authors.initials: A
authors.lastname: Halkola
authors.forename: Jurgen
authors.initials: J
authors.lastname: Rahmer
authors.forename: Jorn
authors.initials: J
authors.lastname: Borgert
authors.forename: Steven M
authors.initials: SM
authors.lastname: Conolly
authors.forename: Kannan M
authors.initials: KM
authors.lastname: Krishnan
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles