title: Notch signaling in the pathologic adult brain.
abstract: Along the entire lifetime, Notch is actively involved in dynamic changes in the cellular architecture and function of the nervous system. It controls neurogenesis, the growth of axons and dendrites, synaptic plasticity, and ultimately neuronal death. The specific roles of Notch in adult brain plasticity and neurological disorders have begun to be unraveled in recent years, and pieces of experimental evidence suggest that Notch is operative in diverse brain pathologies including tumorigenesis, stroke, and neurological disorders such as Alzheimer's disease, Down syndrome, and multiple sclerosis. In this review, we will cover the recent findings of Notch signaling and neural dysfunction in adult human brain and discuss its relevance in the pathogenesis of diseases of the central nervous system.
authors.forename: Patricia
authors.initials: P
authors.lastname: Mathieu
authors.forename: Pamela V Martino
authors.initials: PV
authors.lastname: Adami
authors.forename: Laura
authors.initials: L
authors.lastname: Morelli
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology*; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology; D004314:Down Syndrome / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology; D055495:Neurogenesis; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch