title: Pharmacological aspects of release from microcapsules - from polymeric multilayers to lipid membranes.
abstract: This review is devoted to pharmacological applications of principles of release from capsules to overcome the membrane barrier. Many of these principles were developed in the context of polymeric multilayer capsule membrane modulation, but they are also pertinent to liposomes, polymersomes, capsosomes, particles, emulsion-based carriers and other carriers. We look at these methods from the physical, chemical or biological driving mechanisms point of view. In addition to applicability for carriers in drug delivery, these release methods are significant for another area directly related to pharmacology - modulation of the permeability of the membranes and thus promoting the action of drugs. Emerging technologies, including ionic current monitoring through a lipid membrane on a nanopore, are also highlighted.
authors.affiliation: Photonics Research Group, Department of Information Technology, Ghent University - imec, B-9000 Ghent, Belgium; Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Wuytens
authors.affiliation: A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Parakhonskiy
authors.affiliation: Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia; Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
authors.forename: Alexey
authors.initials: A
authors.lastname: Yashchenok
authors.affiliation: Biophysics, School of Engineering and Sciences, Jacobs University of Bremen, 28759 Bremen, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Winterhalter
authors.affiliation: Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium; Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany. Electronic address: Andre.Skirtach@UGent.be.
authors.forename: Andre
authors.initials: A
authors.lastname: Skirtach
mesh_terms: D002214:Capsules / Q000008:administration & dosage / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D002214:Capsules; D004337:Drug Carriers; D008563:Membrane Lipids; D011108:Polymers