title: Trends in the management of recurrent respiratory papillomatosis in Japan.
abstract: OBJECTIVE
  Recurrent respiratory papillomatosis (RRP) has historically been and still continues to be a difficult disease to treat. The present study aimed to characterize current practices in the treatment of RRP in Japan.
  
  
  METHODS
  A questionnaire was posted to the Department of Otolaryngology of all 80 central university hospitals in Japan.
  
  
  RESULTS
  A total of 56 universities responded to the survey. Regarding the use of surgical instruments, a trend toward a preference for lasers (50 hospitals) rather than a microdebrider (16 hospitals) or cold instruments (20 hospitals) was observed. Among the 50 hospitals frequently performing laser surgery, a carbon dioxide (CO2) laser was most commonly used, followed by a potassium-titanyl-phosphate (KTP) laser. The most favored adjuvant therapy was traditional Chinese medicine. Eight of the 56 university hospitals had an experience of using cidofovir, involving a total of 28 patients.
  
  
  CONCLUSIONS
  The present study demonstrated the current trends in the management of RRP based on a questionnaire survey in a geographical area other than the US and UK for the first time. Treatment trends were generally similar in all three areas except for the least popular use of cidofovir in Japan.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan. Electronic address: murono@med.kanazawa-u.ac.jp.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murono
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakanishi
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuji
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Endo
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Wakisaka
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003646:Debridement; D019468:Disease Management; D006801:Humans; D007564:Japan; D053685:Laser Therapy / Q000379:methods*; D054020:Lasers, Gas; D053844:Lasers, Solid-State; D008516:Medicine, Chinese Traditional / Q000379:methods*; D063065:Organophosphonates / Q000627:therapeutic use*; D010036:Otolaryngology / Q000639:trends*; D030361:Papillomavirus Infections / Q000628:therapy*; D010818:Practice Patterns, Physicians' / Q000639:trends*; D012141:Respiratory Tract Infections / Q000628:therapy*; D011795:Surveys and Questionnaires
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir
keywords: Cidofovir; Japan; Respiratory papillomatosis; Survey; Therapy