title: Quantification of local changes in myocardial motion by diffeomorphic registration via currents: application to paced hypertrophic obstructive cardiomyopathy in 2D echocardiographic sequences.
abstract: Time-to-peak measurements and single-parameter observations are cumbersome and often confusing for quantifying local changes in myocardial function. Recent spatiotemporal normalization techniques can provide a global picture of myocardial motion and strain patterns and overcome some of these limitations. Despite these advances, the quantification of pattern changes remains descriptive, which limits their relevance for longitudinal studies. Our paper provides a new perspective to the longitudinal analysis of myocardial motion. Non-rigid registration (diffeomorphic registration via currents) is used to match pairs of patterns, and pattern changes are inferred from the registration output. Scalability is added to the different components of the input patterns in order to tune up the contributions of the spatial, temporal and magnitude dimensions to data changes, which are of interest for our application. The technique is illustrated on 2D echocardiographic sequences from 15 patients with hypertrophic obstructive cardiomyopathy. These patients underwent biventricular pacing, which aims at provoking mechanical dyssynchrony to reduce left ventricular outflow tract (LVOT) obstruction. We demonstrate that our method can automatically quantify timing and magnitude changes in myocardial motion between baseline (non-paced) and 1 year follow-up (pacing on), resulting in a more robust analysis of complex patterns and subtle changes. Our method helps confirming that the reduction of LVOT pressure gradient actually comes from the induction of the type of dyssynchrony that was expected.
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: nicolas.duchateau@upf.edu.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Duchateau
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain; Université de Montréal, Montreal Heart Institute, Canada.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Giraldeau
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain; Advanced Center for Chronic Diseases, Escuela de medicina, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Luigi
authors.initials: L
authors.lastname: Gabrielli
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Fernández-Armenta
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Penela
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Reinder
authors.initials: R
authors.lastname: Evertz
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Mont
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Brugada
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Berruezo
authors.affiliation: Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sitges
authors.affiliation: Universitat Pompeu Fabra, Barcelona, Spain; ICREA, Barcelona, Spain.
authors.forename: Bart H
authors.initials: BH
authors.lastname: Bijnens
mesh_terms: D058406:Cardiac Resynchronization Therapy; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004452:Echocardiography / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009038:Motion; D009068:Movement; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D016896:Treatment Outcome; D014694:Ventricular Outflow Obstruction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*
keywords: Currents; Deformation-based morphometry; Diffeomorphic registration; Hypertrophic cardiomyopathy; Myocardial motion