title: Biologicals, platelet apoptosis and human diseases: An outlook.
abstract: Platelets, once considered mediators of hemostasis and thrombosis, are now known to be involved in wound healing, inflammation, cardiovascular diseases, diabetes, arthritis, and cancer. Recent reports attest that platelets possess the cellular machinery to undergo apoptosis and that platelet apoptosis can be triggered by myriad stimuli including chemical and physical agonists, and pathophysiological conditions. Augmented rate of platelet apoptosis leads to thrombocytopenia, bleeding disorders and microparticle generation. Despite knowing the significant role of platelets in health and disease, and that any alterations in platelet functions can wreak havoc to the health, the offshoot reactions of therapeutic drugs on platelets and the far-reaching consequences are often neglected. The present review focuses on the impact of platelet apoptosis and the role of platelet-derived microparticles on different pathophysiological conditions. It also touches upon the effects of biologicals on platelets, and discusses the need to overcome the adverse effects of pro-apoptotic drugs through auxiliary therapy.
authors.affiliation: DOS in Biochemistry, University of Mysore, Manasagangothri, Mysore 570 006, India.
authors.forename: R M
authors.initials: RM
authors.lastname: Thushara
authors.affiliation: DOS in Biochemistry, University of Mysore, Manasagangothri, Mysore 570 006, India; Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Hemshekhar
authors.affiliation: Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India.
authors.lastname: Basappa
authors.affiliation: DOS in Biochemistry, University of Mysore, Manasagangothri, Mysore 570 006, India.
authors.forename: K
authors.initials: K
authors.lastname: Kemparaju
authors.affiliation: DOS in Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Rangappa
authors.affiliation: DOS in Biochemistry, University of Mysore, Manasagangothri, Mysore 570 006, India; DOS and Research in Biochemistry, Tumkur University, Tumkur 572 103, India. Electronic address: ksgbaboo@gmail.com.
authors.forename: K S
authors.initials: KS
authors.lastname: Girish
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001791:Blood Platelet Disorders / Q000209:etiology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D055252:Cell-Derived Microparticles; D006801:Humans
keywords: Biologicals; Cancer; Cardiovascular diseases; Microparticles; Platelet apoptosis