title: Interplay of thermal and covalent gelation of silanized hydroxypropyl methyl cellulose gels.
abstract: Silanized hydroxypropyl methyl cellulose (Si-HPMC) is a biocompatible polysaccharide that forms a covalently crosslinked hydrogel at all temperatures due to silanol condensation. Unmodified HPMC forms reversible turbid physical gels when heated above 55°C. The interaction between thermal gelation and covalent crosslinking of Si-HPMC was investigated with rheology, turbidity and microscopy. Thermal gelation of the HPMC backbone was found to reinforce Si-HPMC gels at room temperature. However, simultaneous thermal and covalent crosslinking at higher temperatures led to weaker turbid gels at room temperature. The effect of the pH and the addition of orthophosphate on the elastic modulus and the gelation kinetics was investigated.
authors.affiliation: IMMM UMR-CNRS 6283, PCI, Université du Maine, 72085 Le Mans cedex 9, France.
authors.forename: Shahin
authors.initials: S
authors.lastname: Allahbash
authors.affiliation: IMMM UMR-CNRS 6283, PCI, Université du Maine, 72085 Le Mans cedex 9, France. Electronic address: Taco.Nicolai@univ-lemans.fr.
authors.forename: Taco
authors.initials: T
authors.lastname: Nicolai
authors.affiliation: IMMM UMR-CNRS 6283, PCI, Université du Maine, 72085 Le Mans cedex 9, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Chassenieux
authors.affiliation: IMMM UMR-CNRS 6283, PCI, Université du Maine, 72085 Le Mans cedex 9, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Tassin
authors.affiliation: IMMM UMR-CNRS 6283, PCI, Université du Maine, 72085 Le Mans cedex 9, France.
authors.forename: Lazhar
authors.initials: L
authors.lastname: Benyahia
authors.affiliation: INSERM, Centre Hopsitalier Universitaire de Nantes, Université de Nantes, LIOAD, UMR S 791, 44042 Nantescedex 01, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Weiss
authors.affiliation: INSERM, Centre Hopsitalier Universitaire de Nantes, Université de Nantes, LIOAD, UMR S 791, 44042 Nantescedex 01, France.
authors.forename: Gildas
authors.initials: G
authors.lastname: Rethore
mesh_terms: D055119:Elastic Modulus; D005782:Gels; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives / Q000737:chemistry*; D007700:Kinetics; D012821:Silanes / Q000737:chemistry*; D013696:Temperature
chemical_list: D005782:Gels; D012821:Silanes; D065347:Hypromellose Derivatives
keywords: Gel; Hydroxypropyl methyl cellulose; Rheology; Turbidity, Silanization