title: Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.
abstract: There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders. This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter. PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and controls (never-smokers without mood disorders; n=113). Logistic regression analyses showed that comorbid mood disorders and TUD were associated with significantly lower PON1 activity, the STin2.10/10 genotype (protective) or the Stin2.12 allele (risk factor) and the GSTM1 and GSTT1 null genotypes (protective). These results show that comorbid mood disorders and TUD are associated with specific biomarkers related to oxidative stress and serotonin pathways.
authors.affiliation: Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil; Department of Clinical Medicine, Health Sciences Center, Londrina State University, University Hospital, Londrina, Paraná, Brazil; Department of Psychiatry, Chulalongkorn University, Faculty of Medicine, Bangkok, Thailand.
authors.forename: Sandra Odebrecht
authors.initials: SO
authors.lastname: Vargas Nunes
authors.affiliation: Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil.
authors.forename: Márcia Regina
authors.initials: MR
authors.lastname: Pizzo de Castro
authors.affiliation: Department of Physiological Sciences, Biological Sciences Center, Londrina State University, Paraná, Brazil; Department of Psychiatry, Chulalongkorn University, Faculty of Medicine, Bangkok, Thailand.
authors.forename: Estefania Gastaldello
authors.initials: EG
authors.lastname: Moreira
authors.affiliation: Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Paraná, Brazil.
authors.forename: Roberta Losi
authors.initials: RL
authors.lastname: Guembarovski
authors.affiliation: Department of Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil; Department of Psychiatry, Chulalongkorn University, Faculty of Medicine, Bangkok, Thailand.
authors.forename: Decio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
authors.affiliation: Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil; Department of Clinical Medicine, Health Sciences Center, Londrina State University, University Hospital, Londrina, Paraná, Brazil.
authors.forename: Heber Odebrecht
authors.initials: HO
authors.lastname: Vargas
authors.affiliation: Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil.
authors.forename: Luiz Gustavo
authors.initials: LG
authors.lastname: Piccoli de Melo
authors.affiliation: Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Brazil.
authors.forename: Chiara Cristina
authors.initials: CC
authors.lastname: Bortolasci
authors.affiliation: Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Paraná, Brazil.
authors.forename: Maria Angelica Ehara
authors.initials: MA
authors.lastname: Watanabe
authors.affiliation: IMPACT Strategic Research Centre, Deakin University, Geelong, Australia; Orygen Youth Health Research Centre and the Centre of Youth Mental Health, The Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville, Australia.
authors.forename: Seetal
authors.initials: S
authors.lastname: Dodd
authors.affiliation: IMPACT Strategic Research Centre, Deakin University, Geelong, Australia; Orygen Youth Health Research Centre and the Centre of Youth Mental Health, The Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.affiliation: IMPACT Strategic Research Centre, Deakin University, Geelong, Australia; Department of Psychiatry, Chulalongkorn University, Faculty of Medicine, Bangkok, Thailand; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Brazil. Electronic address: dr.michaelmaes@hotmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D056726:Genetic Association Studies; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; D005982:Glutathione Transferase; D050486:Serotonin Plasma Membrane Transport Proteins; C493230:SLC6A4 protein, human; C413545:glutathione S-transferase T1; C468406:PON1 protein, human
keywords: Depression; Genetic; Mood disorders; Oxidative stress; Polymorphism; Serotonin; Tobacco use disorder