title: Comparison of the effects on brain stimulation reward of D1 blockade or D2 stimulation combined with AMPA blockade in the extended amygdala and nucleus accumbens.
abstract: This report compares the effects on medial forebrain bundle self-stimulation of injecting into either the sublenticular central extended amygdala (SLEAc) or nucleus accumbens shell (NAcS) the D1 dopamine receptor blocker SCH23390 or the D2 dopamine receptor agonist quinpirole alone or in combination with the AMPA glutamate receptor blocker NBQX. These manipulations all render affected neurons less excitable and therefore are expected to increase the stimulation pulse frequency required to maintain half-maximal response rate (required frequency, or RF). Injections were made ipsilateral and contralateral to the stimulation site but not bilaterally. Injecting quinpirole alone or in combination with NBQX was more effective in increasing RF than was injecting SCH23390 either alone or with NBQX. Quinpirole alone and in combination with NBQX was more effective when injected into the SLEAc than into the NAcS, and the combination injection was more effective than quinpirole alone, especially when injected into the SLEAc contralateral to the stimulation site. Maximum response rates were only modestly decreased by any drug injection. These data suggest a stronger role in brain stimulation reward for D2/glutamate than D1/glutamate interactions in the extended amygdala.
authors.affiliation: Department of Psychology, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA; Department of Biological Science, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA. Electronic address: waraczym@uww.edu.
authors.forename: Meg
authors.initials: M
authors.lastname: Waraczynski
authors.affiliation: Department of Psychology, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA; Department of Biological Science, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA.
authors.forename: Lucas
authors.initials: L
authors.lastname: Kuehn
authors.affiliation: Department of Psychology, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA; Department of Biological Science, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA.
authors.forename: Ethan
authors.initials: E
authors.lastname: Schmid
authors.affiliation: Department of Psychology, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA; Department of Biological Science, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Stoehr
authors.affiliation: Department of Psychology, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA; Department of Biological Science, University of Wisconsin - Whitewater, 800 West Main Street, Whitewater, WI, 53190, USA.
authors.forename: Wes
authors.initials: W
authors.lastname: Zwifelhofer
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology; D002755:Choice Behavior / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004359:Drug Therapy, Combination; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects*; D011810:Quinoxalines / Q000008:administration & dosage / Q000494:pharmacology; D019257:Quinpirole / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects
chemical_list: D001552:Benzazepines; D011810:Quinoxalines; D018091:Receptors, AMPA; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C534628:SCH 23390; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D019257:Quinpirole; D018698:Glutamic Acid
keywords: Dopamine; Extended amygdala; Glutamate; Nucleus accumbens; Reward; Self-stimulation