title: Antidepressant agents in short bowel syndrome.
abstract: OBJECTIVE
  This study aimed to determine whether short small intestine modifies antidepressant concentrations.
  
  
  METHODS
  The Css values and concentration-dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome.
  
  
  RESULTS
  Eight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low Css values, including 1 patient who received intravenous treatment.
  
  
  CONCLUSIONS
  The variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.
authors.affiliation: VariaPsy, Variability of the Response to Psychotropic Drugs, Paris Descartes and Paris Diderot Universities, Paris, France; Unit of Therapeutic Research, Department of Internal Medicine, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Faye
authors.affiliation: Department of Gastroenterology and Nutrition Support, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Clichy, France; University of Paris Diderot, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Corcos
authors.affiliation: Unit of Psychopharmacology, Sainte-Anne Hospital, Paris, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Lancelin
authors.affiliation: VariaPsy, Variability of the Response to Psychotropic Drugs, Paris Descartes and Paris Diderot Universities, Paris, France; Department of Pharmacy-Pharmacology-Toxicology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Declèves
authors.affiliation: VariaPsy, Variability of the Response to Psychotropic Drugs, Paris Descartes and Paris Diderot Universities, Paris, France; Unit of Therapeutic Research, Department of Internal Medicine, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bergmann
authors.affiliation: Department of Gastroenterology and Nutrition Support, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Clichy, France; University of Paris Diderot, France.
authors.forename: Francisca
authors.initials: F
authors.lastname: Joly
authors.affiliation: VariaPsy, Variability of the Response to Psychotropic Drugs, Paris Descartes and Paris Diderot Universities, Paris, France; Unit of Therapeutic Research, Department of Internal Medicine, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France. Electronic address: celialloret@yahoo.fr.
authors.forename: Célia
authors.initials: C
authors.lastname: Lloret-Linares
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015283:Citalopram / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012778:Short Bowel Syndrome / Q000150:complications / Q000378:metabolism*
chemical_list: D000928:Antidepressive Agents; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors
keywords: absorption; citalopram; escitalopram; short bowel syndrome; therapeutic drug monitoring