title: Effects of perfluorooctane sulfuric acid on placental PRL-family hormone production and fetal growth retardation in mice.
abstract: Perfluorooctane sulfuric acid (PFOS) is a persistent organic pollutant, causes fetal growth retardation but the mechanism is still unclear. This study focused on PFOS-induced toxicity such as placental trophoblast cell histopathological changes, endocrine function (i.e., prolactin (PRL)-family hormone production) and subsequent fetal growth retardation in mice. Maternal body weight gain, placental and fetal weights were significantly decreased in proportion to PFOS dosage. Placental efficiency (fetal weight/placental weight) was significantly reduced dose-dependently. Necrotic changes were observed in PFOS-treated placental tissues, and the area of injury increased dose-dependently. Finally, mRNA levels and maternal serum concentrations of the PRL-family hormones (mPL-II, mPLP-Cα, mPLP-K) were significantly reduced dose-dependently. In addition, the changing pattern between PRL-family hormone concentrations and fetal body weight was positively correlated. These results suggest that gestational PFOS treatment induces placental histopathological changes and disruption of endocrine function, finally may lead to fetal growth retardation in mice.
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Chae Kwan
authors.initials: CK
authors.lastname: Lee
authors.affiliation: School of Biotechnology and Biomedical Sciences, Inje University, Kimhae 621-749, Republic of Korea. Electronic address: biosgkan@inje.ac.kr.
authors.forename: Sung Goo
authors.initials: SG
authors.lastname: Kang
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Lee
authors.affiliation: Department of Microbiology and Immunology, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Soo-Woong
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Occupational and Environmental Medicine, Inje University Haeundae Paik Hospital, Busan 621-896, Republic of Korea.
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Son
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Kun Hyung
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Chun Hui
authors.initials: CH
authors.lastname: Suh
authors.affiliation: Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
authors.forename: Se Yeong
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Food Processing and Bakery, Gangwon Provincial College, Gangnung Republic of Korea 210-804.
authors.forename: Yeong Beom
authors.initials: YB
authors.lastname: Park
mesh_terms: D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004622:Embryo, Mammalian; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D005466:Fluorocarbons / Q000633:toxicity*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D051379:Mice; D010926:Placental Hormones / Q000097:blood / Q000235:genetics; D011247:Pregnancy; D011388:Prolactin / Q000097:blood* / Q000235:genetics*; D050817:Transcription Factor Pit-1 / Q000235:genetics; D014327:Trophoblasts / Q000187:drug effects / Q000473:pathology*
chemical_list: D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; D010926:Placental Hormones; D011388:Prolactin; D050817:Transcription Factor Pit-1; C494185:Pou1f1 protein, mouse; C076994:perfluorooctane sulfonic acid
keywords: Fetal growrh retardation; PFOS; Placenta; Placental lactogen; Prolactin-like protein