title: Prospective, multi-center evaluation of a silicon carbide coated cobalt chromium bare metal stent for percutaneous coronary interventions: two-year results of the ENERGY Registry.
abstract: BACKGROUND
  Novel bare metal stents with improved stent design may become a viable alternative to drug-eluting stents in certain patient groups, particularly, when long-term dual antiplatelet therapy should be avoided.
  
  
  OBJECTIVE
  The ENERGY registry aimed to assess the safety and benefits of a cobalt-chromium thin strut bare metal stent with a passive coating in a large series of patients under real-world conditions.
  
  
  METHODS
  This prospective registry recruited 1016 patients with 1074 lesions in 48 centers from April to November 2010. The primary endpoint was the rate of major adverse cardiac events (MACEs), a composite of cardiac death, myocardial infarction and clinically driven target lesion revascularization.
  
  
  RESULTS
  More than half of the lesions (61.0%) were type A/B1 lesions, mean lesion length was 14.5±6.5mm and mean reference vessel diameter 3.2±0.5mm. MACE rates at 6, 12 and 24months were 4.9%, 8.1% and 9.4%, target lesion revascularization rates 2.8%, 4.9% and 5.4% and definite stent thrombosis rates 0.5%, 0.6% and 0.6%. Subgroups showed significant differences in baseline and procedural characteristics which did not translate into significantly different clinical outcomes. Specifically, MACE rates at 24months were 13.5% in diabetics, 8.6% in small stents and 9.6% in acute coronary syndrome patients.
  
  
  CONCLUSIONS
  The population of ENERGY reflects real-world conditions with bare metal stents being mainly used in simple lesions. In this setting, percutaneous coronary intervention using a cobalt-chromium thin strut bare metal stent with a passive coating showed very good results up to 24months. (ClinicalTrials.gov:NCT01056120) SUMMARY FOR ANNOTATED TABLE OF CONTENTS: The ENERGY international registry evaluated the safety and benefits of a cobalt-chromium thin strut bare metal stent with passive coating in 1016 patients under real-world conditions until 2years. Results were encouraging with a low composite rate of cardiac death, myocardial infarction and clinically driven target lesion revascularization, even in the pre-defined high risk groups of diabetes, stents ≤2.75mm and acute coronary syndrome.
authors.affiliation: Department of Cardiology, University of Duisburg-Essen, Essen, Germany. Electronic address: erbel@uk-essen.de.
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.affiliation: Cardioangiological Center Bethanien (CCB), Frankfurt, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Eggebrecht
authors.affiliation: Department of Cardiology, Rambam Medical Center, Haifa, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Roguin
authors.affiliation: Division of Cardiovascular Medicine, Cliniques Universitaires de Mont-Godinne, Yvoir, Belgium.
authors.forename: Erwin
authors.initials: E
authors.lastname: Schroeder
authors.affiliation: Department Internal Medicine/Cardiology, Elbe Klinikum Stade, Stade, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Philipp
authors.affiliation: Department of Cardiology, Heart Center Dortmund, Dortmund, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Heitzer
authors.affiliation: Department of Internal Medicine, Diakonissen-Stiftungs- Krankenhaus Speyer, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Schwacke
authors.affiliation: The Heart Institute, Kaplan Medical Center, Rehovot, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Ayzenberg
authors.affiliation: Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Serra
authors.affiliation: Cardiology unit, Pau General Hospital, Pau, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delarche
authors.affiliation: Department of Internal Medicine/Cardiology, Universitätsklinikum Regensburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Luchner
authors.affiliation: Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors.forename: Ton
authors.initials: T
authors.lastname: Slagboom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017554:Carbon Compounds, Inorganic; D002857:Chromium; D002858:Chromium Alloys; D023903:Coronary Restenosis / Q000628:therapy; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011446:Prospective Studies; D012042:Registries; D017655:Silicon Compounds; D016896:Treatment Outcome
chemical_list: D017554:Carbon Compounds, Inorganic; D002858:Chromium Alloys; D017655:Silicon Compounds; D002857:Chromium; C022088:silicon carbide
keywords: Bare metal stent; Passive coating; Silicon carbide