title: The use of LigaSure™ Does not Affect Histologic Margin Assessment in Pancreatoduodenectomy (PD) specimens.
abstract: BACKGROUND
  LigaSure™ is considered safe in performing pancreaticoduodenectomy (PD). However, no data are available regarding the possible damage of tissues at the resection margins and the impact thereof on histologic margin assessment.
  
  
  OBJECTIVE
  This study compares the degree of histologic damage to the resection margins when using LigaSure™ (Group 1) or traditional ligature (Group 2).
  
  
  METHODS
  Both groups included 8 consecutive patients who underwent PD at Karolinska Institute in December 2013 (Group 1) or earlier (Group 2) by the same surgeon (M.D.C.). The quality of tissues at the circumferential margins was compared between both groups by scoring for three different kinds of damage: tissue fragmentation, hemorrhage, and cell damage.
  
  
  RESULTS
  The mean score for fragmentation was 1.3 (Group 1) versus 1.7 (Group 2; P=0.1). For hemorrhage the mean score was 0.8 (Group 1) versus 1.5 (Group 2; P=0.04). The mean score for cell damage was 1.4 (Group 1) compared to 1.2 (Group 2; P=0.1).
  
  
  CONCLUSIONS
  LigaSure™ does not cause tissue damage that could affect histologic margin assessment in PD specimens.
authors.affiliation: Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute. Stockholm, Sweden. marco.del-chiaro@karolinska.se.
authors.forename: Marco
authors.initials: M
authors.lastname: Del Chiaro
authors.forename: John
authors.initials: J
authors.lastname: Blomberg
authors.forename: Ralf
authors.initials: R
authors.lastname: Segersvärd
authors.forename: Elena
authors.initials: E
authors.lastname: Rangelova
authors.forename: Christoph
authors.initials: C
authors.lastname: Ansorge
authors.forename: Caroline
authors.initials: C
authors.lastname: Verbeke