title: Asthma: the interplay between viral infections and allergic diseases.
abstract: Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.
authors.affiliation: Pediatric Infectious Diseases Fellowship Program, Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA.
authors.forename: Regina K
authors.initials: RK
authors.lastname: Rowe
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases and Division of Pulmonary Vascular Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA; Department of Immunology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA. Electronic address: michelle.gill@utsouthwestern.edu.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Gill
mesh_terms: D001249:Asthma / Q000276:immunology* / Q000821:virology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology* / Q000821:virology; D007073:Immunoglobulin E / Q000276:immunology; D007370:Interferon Type I; D010850:Picornaviridae Infections / Q000276:immunology* / Q000821:virology; D011983:Receptors, Purinergic / Q000235:genetics / Q000276:immunology; D020545:Respiratory Mucosa / Q000276:immunology; D012229:Rhinovirus / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: D007370:Interferon Type I; D011983:Receptors, Purinergic; D007073:Immunoglobulin E
keywords: Allergy; Asthma; Atopy; Dendritic cells; Immunoglobulin E; Rhinovirus; Type I interferon; Viral infection