title: Goodpasture's syndrome: a clinical update.
abstract: Goodpasture's syndrome (GS) is a rare and organ-specific autoimmune disease that is mediated by anti-glomerular basement membrane (anti-GBM) antibodies and has pathology characterized by crescentic glomerulonephritis with linear immunofluorescent staining for IgG on the GBM. It typically presents as acute renal failure caused by a rapidly progressive glomerulonephritis, accompanied by pulmonary hemorrhage that may be life-threatening. It was first described as a distinctive syndrome by Pasture in 1919. Autoimmune Inner Ear Disease (AIED) may be associated. The etiology of GS is unknown. Researchers hypothesized a genetic predisposition HLA-associated. Complex immunological mechanisms are in the pathogenesis. The disease is caused by autoantibodies against the NC1 domain of the alpha 3 chain of type IV collagen. The limited presence of this molecule in the body explains the interest confined to specific target organs, such as the lung and kidney. It occurs when the immune system attacks the walls of the lungs and the tiny filtering units in the kidneys. Without prompt diagnosis and treatment, the disease can lead to bleeding in the lungs, kidney failure, and even death.
authors.affiliation: Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Greco
authors.affiliation: Department of Surgical Science, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Maria Ida
authors.initials: MI
authors.lastname: Rizzo
authors.affiliation: Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy; Department of Surgical Science, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy. Electronic address: armando.devirgilio@gmail.com.
authors.forename: Armando
authors.initials: A
authors.lastname: De Virgilio
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Otorhinolaryngology Section, 'Sapienza' University of Rome, Corso della Repubblica, 79, 04100 Latina, LT, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallo
authors.affiliation: Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Fusconi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Otorhinolaryngology Section, 'Sapienza' University of Rome, Corso della Repubblica, 79, 04100 Latina, LT, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Pagliuca
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Otorhinolaryngology Section, 'Sapienza' University of Rome, Corso della Repubblica, 79, 04100 Latina, LT, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Martellucci
authors.affiliation: Department Organs of Sense, Audiology Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Turchetta
authors.affiliation: Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Longo
authors.affiliation: Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: De Vincentiis
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000906:Antibodies; D001324:Autoantigens; D000939:Epitopes
keywords: ANCAs; Anti-GBM antibodies; Anti-GBM disease; Crescentic glomerulonephritis; Goodpasture syndrome; Pulmonary-renal syndrome