title: Arrested detachment: a DEPDC1B-mediated de-adhesion mitotic checkpoint.
abstract: Mitotic cell rounding is accompanied by changes in the actin cytoskeleton, de-adhesion, and an increase in cortical rigidity. In this issue, Marchesi et al. (2014) describe an adhesion-dependent mitotic checkpoint and identify DEPDC1B as the factor responsible for coordinating de-adhesion with the ability of cells to enter mitosis.
authors.affiliation: Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA. Electronic address: rafael.garciamata@utoledo.edu.
authors.forename: Rafael
authors.initials: R
authors.lastname: Garcia-Mata
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D015027:Zebrafish / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C000595201:DEPDC1B protein, zebrafish; D029961:Zebrafish Proteins