title: High-throughput screening for integrative biomaterials design: exploring advances and new trends.
abstract: With the increasing need for biomaterials and tissue engineering alternatives, more accurate, rapid, and cost-saving methods and models to study biomaterial-cell interactions must be developed. We review the evolution of microarray platforms used for such studies in order to meet the criteria of complex tissue engineering biological environments. Particular aspects regarding biomaterials processing, data acquisition, and treatment are addressed. Apart from in vitro array-based strategies, we also address emerging in vivo high-throughput approaches and their associated trends, such as the role of inflammation in regeneration. The up-scaling of high-throughput methods using single cell encapsulation systems is also explored. Possible limitations related to the use of such methods, such as spot-to-spot crosstalk, are also discussed.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors.forename: Mariana B
authors.initials: MB
authors.lastname: Oliveira
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: jmano@dep.uminho.pt.
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
mesh_terms: D001672:Biocompatible Materials / Q000302:isolation & purification* / Q000633:toxicity; D001709:Biotechnology / Q000379:methods* / Q000639:trends; D057166:High-Throughput Screening Assays / Q000639:trends*; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D001672:Biocompatible Materials
keywords: arrays; biomaterials; combinatorial; high-throughput; lab-on-chip testing