title: [Immunopathogenesis of invasive mould infections].
abstract: Invasive fungal infections caused by filamentous fungi are devastating diseases that occur in patients with a variety of immunosuppressive conditions. This review focuses on the pathogenesis of the most important invasive mycosis in the human being caused by the filamentous fungi Aspergillus, Fusarium, Scedosporium and mucorales. The first contact between the mould and the patient, the host defense to different fungi, including the role of mucosa in the innate immune system, the whole innate immune recognition receptors, and the pathways connecting innate and adaptive immunity, as well as the virulence factors of fungi, are discussed in this paper.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España. Electronic address: carolgv75@hotmail.com.
authors.forename: Carolina
authors.initials: C
authors.lastname: García-Vidal
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Universitario La Fe, Valencia, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Salavert Lletí
mesh_terms: D056704:Adaptive Immunity; D000908:Antibodies, Fungal / Q000096:biosynthesis / Q000276:immunology; D001228:Aspergillosis / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D016469:Fungemia / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D005658:Fungi / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D060585:Fusariosis / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal / Q000276:immunology; D016867:Immunocompromised Host; D037102:Lectins / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism; D018448:Models, Immunological; D009091:Mucormycosis / Q000209:etiology / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D021681:Scedosporium / Q000302:isolation & purification / Q000472:pathogenicity; D051193:Toll-Like Receptors / Q000276:immunology; D014774:Virulence / Q000235:genetics
chemical_list: D000908:Antibodies, Fungal; D037102:Lectins; D008222:Lymphokines; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors
keywords: Aspergillus; Dectin-1; Dectina-1; Fusarium; Mucorales; Pentraxin-3; Pentraxina-3; Receptores toll-like; Scedosporium; Toll-like receptors