title: Significance of association of HLA-C and HLA-E with psoriatic arthritis.
abstract: Psoriatic arthritis (PsA) is a complex genetic disorder that results from an interplay between multiple genetic and environmental factors. The aim of the study was to assess the significance of the association between the HLA-C and HLA-E allelic groups and PsA. Our results confirm the association between HLA-C(∗)06 and PsA (OR=5.16, p<0.0001). Furthermore, HLA-C(∗)06-positive patients develop more severe disease (p<0.01) and more frequently present with polyarticular pattern of PsA (p=0.08). Additionally our study revealed that the HLA-C(∗)02 allele was more frequently observed in PsA patients (OR=5.40, p<0.0005) and also that the HLA-E(∗)01:01 allele was significantly over-represented among HLA-C(∗)02-negative patients in comparison to healthy individuals (OR=6.44, p=0.045). Therefore these results suggest that the HLA-E and HLA-C(∗)02 molecules may also play an important role in determination immune response contributing to the PsA development.
authors.affiliation: Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Sokolik
authors.affiliation: Laboratory of Clinical Immunogenetics and Pharmacogenetics, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gębura
authors.affiliation: Laboratory of Clinical Immunogenetics and Pharmacogenetics, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
authors.forename: Milena
authors.initials: M
authors.lastname: Iwaszko
authors.affiliation: Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Świerkot
authors.affiliation: Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Korman
authors.affiliation: Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wiland
authors.affiliation: Laboratory of Clinical Immunogenetics and Pharmacogenetics, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. Electronic address: bogunia@iitd.pan.wroc.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bogunia-Kubik
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology; D000097625:HLA-E Antigens
chemical_list: D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C048767:HLA-C*02 antigen; C528994:HLA-C*06 antigen
keywords: Disease phenotype; HLA-C; HLA-E; Polish population (Poles); Psoriatic arthritis