title: Placental dysfunction in obese women and antenatal surveillance strategies.
abstract: This review is aimed at discussing placental dysfunction in obesity and its clinical implication in pregnancy as well as an antenatal surveillance strategy for these women. Maternal obesity is associated with adverse perinatal outcome. Obesity is an independent risk factor for fetal hyperinsulinaemia, birthweight and newborn adiposity. Maternal obesity is associated with childhood obesity and obesity in adult life. Obesity induces a low-grade inflammatory response in placenta, which results in short- and long-term programming of obesity in fetal life. Preconception and antenatal counselling on obstetrics risk in pregnancy, on diet and lifestyle in pregnancy and on gestational weight gain is associated with a better outcome. Fetal growth velocity is closely associated with maternal weight and gestational weight gain. Careful monitoring of gestational weight gain and fetal growth, and screening and management of obstetrical complications such as gestational diabetes and pre-eclampsia, improves perinatal outcome. The use of metformin in non-diabetic obese women is under investigation; further evidence is required before recommending it.
authors.affiliation: University Hospitals of Leicester, Leicester, UK. Electronic address: drybjeve@gmail.com.
authors.forename: Yadava B
authors.initials: YB
authors.lastname: Jeve
authors.affiliation: University Hospitals of Leicester, Leicester, UK.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Konje
authors.affiliation: University Hospitals of Leicester, Leicester, UK.
authors.forename: Anjum
authors.initials: A
authors.lastname: Doshani
mesh_terms: D016640:Diabetes, Gestational / Q000188:drug therapy; D005260:Female; D047109:Fetal Development; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007249:Inflammation; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity; D010922:Placenta Diseases; D011225:Pre-Eclampsia; D011247:Pregnancy; D011248:Pregnancy Complications; D018566:Pregnancy, High-Risk; D011295:Prenatal Care; D015430:Weight Gain
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin
keywords: antenatal; obesity; placental dysfunction