title: Morphological changes in mitochondria during mechanical unloading observed on electron microscopy: a case report of a bridge to complete recovery in a patient with idiopathic dilated cardiomyopathy.
abstract: The recovery of the cardiac function under mechanical support has not been well documented from a histopathological point of view. We herein report a case of idiopathic dilated cardiomyopathy in which the patient showed a complete recovery of the systolic function following treatment with a left ventricular assist device (LVAD) for deteriorated heart failure. A light microscopic observation showed marked regression of hypertrophic myocytes with significant intracellular vacuolization and scarcity at the time of LVAD implantation after the administration of mechanical support. Furthermore, an electron microscopic observation revealed that these findings were regulated primarily by volumetric regression and morphometric improvements in cardiomyocytic mitochondria.
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ikeda
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. Electronic address: inotaka@med.kitasato-u.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Inomata
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Iida
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Nabeta
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Naruke
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Koitabashi
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takeuchi
authors.affiliation: Department of Cardiovascular Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: Department of Cardiovascular Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.
authors.forename: Kagami
authors.initials: K
authors.lastname: Miyaji
authors.affiliation: Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
mesh_terms: D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000473:pathology* / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008928:Mitochondria / Q000648:ultrastructure*
keywords: Dilated cardiomyopathy; Electron microscopy; Left ventricular assist device; Mitochondria; Vacuolization