title: Peripheral nerve regeneration: experimental strategies and future perspectives.
abstract: Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options. This review summarises all the events occurring after nerve damage at the level of the cell body, the site of injury and the target organ. Various experimental strategies to improve neuronal survival, axonal regeneration and target reinnervation are described including pharmacological approaches and cell-based therapies. Given the complexity of nerve regeneration, further studies are needed to address the biology of nerve injury, to improve the interaction with implantable scaffolds, and to implement cell-based therapies in nerve tissue engineering.
authors.affiliation: Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Faroni
authors.affiliation: Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Materials Science Centre, School of Materials, The University of Manchester, Manchester, UK.
authors.forename: S Atefeh
authors.initials: SA
authors.lastname: Mobasseri
authors.affiliation: Section for Anatomy, Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kingham
authors.affiliation: Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK. Electronic address: adam.reid@manchester.ac.uk.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Reid
mesh_terms: D000818:Animals; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000503:physiopathology / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
keywords: Muscle denervation; Neuronal survival; Peripheral nerve regeneration; Reinnervation; Scaffold; Stem cell