title: The role of pleiotrophin in bone repair.
abstract: Bone has an enormous capacity for growth, regeneration, and remodelling, largely due to induction of osteoblasts that are recruited to the site of bone formation. Although the pathways involved have not been fully elucidated, it is well accepted that the immediate environment of the cells is likely to play a role via cell–matrix interactions, mediated by several growth factors. Formation of new blood vessels is also significant and interdependent to bone formation, suggesting that enhancement of angiogenesis could be beneficial during the process of bone repair. Pleiotrophin (PTN), also called osteoblast-specific factor 1, is a heparin-binding angiogenic growth factor, with a well-defined and significant role in both physiological and pathological angiogenesis. In this review we summarise the existing evidence on the role of PTN in bone repair.
authors.forename: Margarita
authors.initials: M
authors.lastname: Lamprou
authors.forename: Angelos
authors.initials: A
authors.lastname: Kaspiris
authors.forename: Elias
authors.initials: E
authors.lastname: Panagiotopoulos
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadimitriou
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D002352:Carrier Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D002454:Cell Differentiation; D016207:Cytokines / Q000494:pharmacology* / Q000627:therapeutic use; D050723:Fractures, Bone / Q000188:drug therapy / Q000473:pathology*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; C066845:pleiotrophin