title: Growth factor and small molecule influence on urological tissue regeneration utilizing cell seeded scaffolds.
abstract: Regenerative medicine strategies combine various attributes from multiple disciplines including stem cell biology, chemistry, materials science and medicine. The junction at which these disciplines intersect provides a means to address unmet medical needs in an assortment of pathologies with the goal of creating sustainable, functional replacement tissues. Tissue damage caused by trauma for example, requires rapid responses in order to mitigate further tissue deterioration. Cell/scaffold composites have been utilized to initiate and stabilize regenerative responses in vivo with the hope that functional tissue can be attained. Along with the gross reconfiguration of regenerating tissues, small molecules and growth factors also play a pivotal role in tissue regeneration. Several regenerative studies targeting a variety of urological tissues demonstrate the utility of these small molecules or growth factors in an in vivo setting.
authors.affiliation: Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Urology, Chicago, IL 60614, USA; Northwestern University Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA; Northwestern University, Simpson Querrey Institute for BioNanotechnology), Chicago, IL 60611 ,USA; Northwestern University, Department of Biomedical Engineering, Evanston, IL 60208, USA. Electronic address: arun-sharma@northwestern.edu.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Urology, Chicago, IL 60614, USA; Northwestern University Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA; Northwestern University, Simpson Querrey Institute for BioNanotechnology), Chicago, IL 60611 ,USA.
authors.forename: Earl Y
authors.initials: EY
authors.lastname: Cheng
mesh_terms: D000818:Animals; D051157:Frizzled Receptors / Q000378:metabolism; D048091:Guided Tissue Regeneration / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D019737:Transplants / Q000378:metabolism*; D014570:Urologic Diseases / Q000601:surgery*; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins
keywords: Angiogenesis; Augmentation enterocystoplasty; Bioscaffold; Elastomer; Hematopoietic stem/progenitor cells; Mesenchymal stem cells; Ureter; Urethra; Wnt genes