title: New silibinin glyco-conjugates: synthesis and evaluation of antioxidant properties.
abstract: New silibinin glyco-conjugates have been synthesized by efficient method and in short time. Exploiting our solution phase strategy, several structurally diverse silibinin glyco-conjugates (gluco, manno, galacto, and lacto-) were successfully realized in very good yields and in short time. In preliminary study to evaluate their antioxidant and neuroprotective activities new derivatives were subjected to DPPH free radical scavenging assay and the Xanthine oxidase (XO) inhibition models assay. Irrespective of the sugar moiety examined, new glyco-conjugates are more than 50 times water-soluble of silibinin. In the other hand they exhibit a radical scavenging activities slightly higher than to silibinin and XO inhibition at least as silibinin.
authors.affiliation: Department of Chemical Sciences, University of Napoli 'Federico II', Via Cinthia 4, I-80126 Napoli, Italy; Consorzio Interuniversitario Sannio Tech, P.zza San G. Moscati 8, SS Appia km 256, 82030 Apollosa (BN), Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Zarrelli
authors.affiliation: Department of Chemical Sciences, University of Napoli 'Federico II', Via Cinthia 4, I-80126 Napoli, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Romanucci
authors.affiliation: Gastroenterology Unit, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Tuccillo
authors.affiliation: Gastroenterology Unit, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Federico
authors.affiliation: Gastroenterology Unit, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Loguercio
authors.affiliation: Department of Chemical Sciences, University of Napoli 'Federico II', Via Cinthia 4, I-80126 Napoli, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Gravante
authors.affiliation: Department of Chemical Sciences, University of Napoli 'Federico II', Via Cinthia 4, I-80126 Napoli, Italy; Consorzio Interuniversitario Sannio Tech, P.zza San G. Moscati 8, SS Appia km 256, 82030 Apollosa (BN), Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Fabio
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D004341:Drug Evaluation / Q000379:methods; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006003:Glycogen / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020944:Silybum marianum; D000077385:Silybin; D012838:Silymarin / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D012838:Silymarin; D000077385:Silybin; D006003:Glycogen
keywords: Glyco-conjugates; Natural products; Phosphoramidite chemistry; Silibinin; Silybin