title: Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology.
abstract: OBJECTIVE
  To study the outcomes of microdissection testicular sperm extraction (microTESE) among men with pure Sertoli cell-only histology on diagnostic testicular biopsy.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Six hundred forty patients with pure Sertoli cell-only histology on testicular biopsy who underwent microTESE by a single surgeon.
  
  
  METHODS
  MicroTESE.
  
  
  METHODS
  Sperm retrieval rates.
  
  
  RESULTS
  Overall, 44.5% of patients with Sertoli cell only had sperm retrieved with microTESE. No difference was noted in sperm retrieval rates based on testis volume (≥15 mL vs. <15 mL, 35.3% vs. 46.1%, respectively). Patients with ≥15 mL testicular volume and FSH 10-15 mU/mL had the worst prognosis, with a sperm retrieval rate of 6.7%.
  
  
  CONCLUSIONS
  Patients with previous testicular biopsy demonstrating Sertoli cell-only histology can be counseled that they have a reasonable likelihood of sperm retrieval with the contemporary delivery of microTESE. Given this finding, the utility of testicular biopsy before microTESE is further questioned.
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, New York; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Boback M
authors.initials: BM
authors.lastname: Berookhim
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Gianpiero D
authors.initials: GD
authors.lastname: Palermo
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Nikica
authors.initials: N
authors.lastname: Zaninovic
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, New York; The Population Council, Center for Biomedical Research, New York, New York. Electronic address: pnschleg@med.cornell.edu.
authors.forename: Peter N
authors.initials: PN
authors.lastname: Schlegel
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000473:pathology*; D002469:Cell Separation / Q000379:methods*; D015331:Cohort Studies; D006801:Humans; D008297:Male; D042282:Microdissection / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D054331:Sertoli Cell-Only Syndrome / Q000473:pathology*; D053625:Sperm Retrieval; D013094:Spermatozoa / Q000737:chemistry / Q000473:pathology*; D013737:Testis / Q000473:pathology*
keywords: Azoospermia; male infertility; sperm retrieval; testicular failure