title: Effect of lemongrass tea consumption on estimated glomerular filtration rate and creatinine clearance rate.
abstract: OBJECTIVE
  The existing research findings regarding the effects of lemongrass (Cymbopogon citratus) tea on renal function indices are conflicting and inconclusive. In the present study, we investigated the effects of infusions prepared from C citratus leaves on creatinine clearance rate (CCr) and estimated glomerular filtration rate (eGFR) in humans.
  
  
  METHODS
  One hundred five subjects (55 men and 50 women) aged 18 to 35 years were randomly assigned to groups set to orally receive infusions prepared from 2, 4, or 8 g of C citratus leaf powder once daily, for 30 days. Serum and urinary levels of urea, creatinine, pH, specific gravity, uric acid, electrolytes, diuretic indices, and eGFR were assessed at days 0, 10, and 30 after the initiation of treatment. Results obtained on days10 and 30 were compared with baseline values.
  
  
  RESULTS
  CCr and eGFR decreased significantly at day 30 in both male and female subjects in all the groups and in females treated with infusion prepared from 8 g of C citratus leaf powder for 10 days. At day 10, CCr and eGFR were unchanged in those treated with infusions prepared from 2 or 4 g of the leaf powder, whereas diuretic indices (urine volume, urination frequency, diuretic action, and saliuretic indices) increased above the baseline levels. Serum and urinary creatinine levels significantly increased (P < .05) in both male and female subjects in all the groups. Serum urea significantly increased in the groups treated with infusions prepared from 4 or 8 g of the leaf powder (P < .05) for 30 days. Serum electrolytes remained unchanged, but their urinary levels increased.
  
  
  CONCLUSIONS
  We observed dose- and time-dependent adverse effects of C citratus on CCr and eGFR. At a high dose or with prolonged treatment with a low dose, eGFR decrease may be followed by a decline in the other renal function indices.
authors.affiliation: Department of Physiology, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria. Electronic address: chrisvon200@yahoo.com.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Ekpenyong
authors.affiliation: Department of Physiology, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria.
authors.forename: Nyebuk E
authors.initials: NE
authors.lastname: Daniel
authors.affiliation: Department of Physiology, College of Health Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
authors.forename: Atim B
authors.initials: AB
authors.lastname: Antai
mesh_terms: D000293:Adolescent; D000328:Adult; D001628:Beverages; D002118:Calcium / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood* / Q000652:urine; D031743:Cymbopogon; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate; D064368:Healthy Volunteers; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D064209:Phytochemicals / Q000008:administration & dosage / Q000009:adverse effects; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects; D018515:Plant Leaves / Q000166:cytology; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine; D014508:Urea / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000652:urine; D055815:Young Adult
chemical_list: D064209:Phytochemicals; D010936:Plant Extracts; D014527:Uric Acid; D014508:Urea; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D002118:Calcium