title: Role of transient receptor potential channels in intestinal inflammation and visceral pain: novel targets in inflammatory bowel diseases.
abstract: Transient receptor potential (TRP) channels are a large group of ion channels that are prevalent in mammalian tissues. They are widely distributed in the central and peripheral nervous systems, and in nonneuronal cells, where they are implicated in sensing temperature, noxious substances, and pain. TRPs play an important role in immune response and nociception and, therefore, may be involved in the pathogenesis of inflammatory bowel diseases, whose major symptoms include chronic inflammatory state and abdominal pain. In this review, we summarize what is known on TRP channels in inflammatory bowel disease and visceral pain; we focus in particular on TRPV1, TRPV4, TRPA1, and TRPM. We also analyze scientific reports that evidence potential use of TRP regulators in future inflammatory bowel disease treatment.
authors.affiliation: *Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Zielińska
authors.forename: Agata
authors.initials: A
authors.lastname: Jarmuż
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wasilewski
authors.forename: Maciej
authors.initials: M
authors.lastname: Sałaga
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D007422:Intestines / Q000187:drug effects / Q000276:immunology; D011379:Prognosis; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors*; D059265:Visceral Pain / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D050051:Transient Receptor Potential Channels