title: Surgical stress induced depressive and anxiety like behavior are improved by dapsone via modulating NADPH oxidase level.
abstract: Surgical stress induced depression and anxiety like behavior are common complications among aged individuals suffering from surgery. Recent studies proposed that accumulation of oxidative stress is involved in the etiology of stress induced depression and anxiety. Dapsone possesses antioxidant properties, however, whether dapsone is effective in modulating surgical stress induced brain oxidative damage remains uncertain. The present study aimed to investigate the effect of dapsone on surgical stress induced depressive and anxiety like behavior, and brain oxidative stress in a well-established surgical stress model. Depressive and anxiety like behavior accompanied by elevated brain oxidative stress were observed in aged mice underwent abdominal surgery. Pretreatment with 5 mg/kg dapsone significantly improved the behavioral disorder and ameliorated brain oxidative stress in this model. Further investigation, revealed that surgical stress increased brain NADPH oxidase level, while pretreatment with dapsone abrogated the elevation of NADPH oxidase triggered by surgical stress. These findings suggest that dapsone is effective in improving surgical stress induced brain oxidative damage via down-regulating NADPH oxidase level in aged mice.
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Tian
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Qiudian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Hecheng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China; Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Zhengqian
authors.initials: Z
authors.lastname: Li
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China; Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Lunxu
authors.initials: L
authors.lastname: Li
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
authors.affiliation: Peking University Sixth Hospital and National Institute on Drug Dependence, Beijing 100191, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle 98104, WA, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
authors.forename: Yinglan
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China; Department of Neurology, Peking University Third Hospital, Beijing 100191, China. Electronic address: dchui@bjmu.edu.cn.
authors.forename: Dehua
authors.initials: D
authors.lastname: Chui
mesh_terms: D000375:Aging / Q000378:metabolism / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003622:Dapsone / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008297:Male; D008810:Mice, Inbred C57BL; D019255:NADPH Oxidases / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D013315:Stress, Psychological / Q000150:complications / Q000201:enzymology*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D003622:Dapsone; D019255:NADPH Oxidases
keywords: Anxiety like behavior; Dapsone; Depressive like behavior; NADPH oxidase; Oxidative stress; Surgical stress