title: DNAJC6 promotes hepatocellular carcinoma progression through induction of epithelial-mesenchymal transition.
abstract: Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with hepatocellular carcinoma (HCC) development and progression. DNAJC6 (DNA/HSP40 homolog subfamily C member 6) encodes auxilin, which is responsible for juvenile Parkinsonism with phenotypic variability. However, the role of DNAJC6 in HCC development and progression is limited. Here, we report that DNAJC6 is up-regulated in HCC tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC. Furthermore, overexpression of DNAJC6 enhances the ability for acquisition of mesenchymal traits, enhanced cell proliferation and invasion. DNAJC6 positively regulated expression of EMT-related transcription factor, also activating transforming growth factor β (TGF-β) pathway to contribute to EMT. Our findings demonstrated an important function of DNAJC6 in the progression of HCC by induction of EMT, and they implicate DNAJC6 as a marker of poor outcome in HCC.
authors.affiliation: Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: General Surgery, Sports Science Institute of Hebei Province, Shijiazhuang 050011, China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Li
authors.affiliation: General Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China.
authors.forename: Xing-Guang
authors.initials: XG
authors.lastname: Li
authors.affiliation: General Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China. Electronic address: pengzhigaovip@163.com.
authors.forename: Peng-Zhi
authors.initials: PZ
authors.lastname: Gao
mesh_terms: D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D050956:HSP40 Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016212:Transforming Growth Factor beta / Q000378:metabolism; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: C494652:DNAJC6 protein, human; D050956:HSP40 Heat-Shock Proteins; D016212:Transforming Growth Factor beta
keywords: DNAJC6; Epithelial–mesenchymal transition; Hepatocellular carcinoma; Transforming growth factor β