title: Growing evidence for topical mometasone fuoroate in the treatment of Vulvar Lichen Sclerosus.
abstract: Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. On the basis of the immunologic changes in VLS, treatment with a high potency topical corticosteroid is recommended. The currently available guidelines identified the ultra-potent corticosteroid clobetasol propionate 0.05% (CP) as the first-line recommended treatment but growing evidence supports the use of the potent corticosteroid mometasone furoate 0.1% (MMF). We reviewed the available studies assessing MMF in the treatment of VLS. Both non comparative and comparative studies were included in this review. Findings from clinical trials indicate that MMF is an effective and safe option in the treatment of VLS both in the active phase and in long-term maintenance treatment. Consistent with the findings from the comparative studies, MMF shows similar efficacy and safety to CP.
authors.affiliation: Sezione di Dermatologia e Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara.
authors.forename: A
authors.initials: A
authors.lastname: Virgili
authors.affiliation: Sezione di Dermatologia e Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara.
authors.forename: M
authors.initials: M
authors.lastname: Corazza
authors.affiliation: Sezione di Dermatologia e Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara.
authors.forename: S
authors.initials: S
authors.lastname: Minghetti
authors.affiliation: Sezione di Dermatologia e Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara. Electronic address: alessandro.borghi@unife.it.
authors.forename: A
authors.initials: A
authors.lastname: Borghi
mesh_terms: D000279:Administration, Cutaneous; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D000068656:Mometasone Furoate / Q000008:administration & dosage*; D011788:Quality of Life; D016896:Treatment Outcome; D007724:Vulvar Lichen Sclerosus / Q000188:drug therapy* / Q000473:pathology; D016387:Women's Health
chemical_list: D000893:Anti-Inflammatory Agents; D000068656:Mometasone Furoate
keywords: active treatment; clobetasol propionate; maintenance treatment; mometasone furoate; vulvar lichen sclerosus