title: Progress in mitochondrial epigenetics.
abstract: Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways. First, epigenetic mechanisms that regulate the expression of nuclear genome influence mitochondria by modulating the expression of nuclear-encoded mitochondrial genes. Second, a cell-specific mitochondrial DNA content (copy number) and mitochondrial activity determine the methylation pattern of nuclear genes. Third, mitochondrial DNA variants influence the nuclear gene expression patterns and the nuclear DNA (ncDNA) methylation levels. Fourth and most recent line of evidence indicates that mitochondrial DNA similar to ncDNA also is subject to epigenetic modifications, particularly by the 5-methylcytosine and 5-hydroxymethylcytosine marks. The latter interaction of mitochondria with epigenetics has been termed 'mitochondrial epigenetics'. Here we summarize recent developments in this particular area of epigenetic research. Furthermore, we propose the term 'mitoepigenetics' to include all four above-noted types of interactions between mitochondria and epigenetics, and we suggest a more restricted usage of the term 'mitochondrial epigenetics' for molecular events dealing solely with the intra-mitochondrial epigenetics and the modifications of mitochondrial genome.
authors.forename: Hari
authors.initials: H
authors.lastname: Manev
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dzitoyeva
mesh_terms: D000818:Animals; D015415:Biomarkers; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors; D019175:DNA Methylation; D004272:DNA, Mitochondrial; D004791:Enzyme Inhibitors / Q000494:pharmacology; D044127:Epigenesis, Genetic / Q000187:drug effects; D057890:Epigenomics; D054629:Genome, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000235:genetics*
chemical_list: D015415:Biomarkers; D004272:DNA, Mitochondrial; D004791:Enzyme Inhibitors; D004248:DNA (Cytosine-5-)-Methyltransferases