title: A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13).
abstract: Background. We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML). Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia) with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD) mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7 + 3 (cytarabine + idarubicin) and achieved complete remission after a second induction with high-dose cytarabine (HiDAC) followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15) (q32; q13), while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected). She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care. Conclusion. Based on this single case of AML with t (14; 15) (q32; q13), this newly reported translocation may be associated with refractory disease.
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA ; University of Oklahoma Health Sciences Center, Stephenson Cancer Center, 800 NE 10th Street, Oklahoma City, OK 73102, USA.
authors.forename: Mohamad
authors.identifier: 0000-0002-6627-1933
authors.initials: M
authors.lastname: Khawandanah
authors.affiliation: Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Bradley
authors.identifier: 0000-0003-1550-3455
authors.initials: B
authors.lastname: Gehrs
authors.affiliation: Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Holter Chakrabarty
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Cherry