title: Impact of an adjuvant chemotherapeutic regimen on the clinical outcome in high risk patients with upper tract urothelial carcinoma: a Japanese multi-institution experience.
abstract: OBJECTIVE
  Current guidelines do not yet provide any recommendations for adjuvant chemotherapy in patients with upper tract urothelial carcinoma managed with radical nephroureterectomy. We evaluated whether an adjuvant chemotherapeutic regimen would affect the clinical outcome in patients with high risk upper tract urothelial carcinoma.
  
  
  METHODS
  We identified 873 patients who had undergone radical nephrouretectomy for localized upper tract urothelial carcinoma at 14 Japanese institutions between 1993 and 2011. We assessed whether the type of regimen, such as methotrexate, vinblastine, doxorubicin and cisplatin, and gemcitabine and cisplatin, in an adjuvant setting, could affect the subsequent clinical outcome of patients with upper tract urothelial carcinoma.
  
  
  RESULTS
  On multivariate analysis pathological T stage, tumor grade, lymphovascular invasion and lymph node involvement were prognostic factors for recurrence-free survival and cancer specific survival. We defined 229 patients with 3 or more of these factors as the high risk group. In an analysis according to adjuvant regimen, Kaplan-Meier curves showed that the 1 and 2-year recurrence-free survival rates in the methotrexate, vinblastine, doxorubicin and cisplatin treated group were 71.4% and 47.9%, which were significantly higher than in the gemcitabine and cisplatin treated group (48.2% and not reached, p=0.022) or those not treated with adjuvant chemotherapy (53.4% and 39.6%, p=0.039). Similar results were observed in terms of cancer specific survival.
  
  
  CONCLUSIONS
  Our study showed that pT3-4, tumor grade 3, positive lymphovascular invasion and lymph node involvement were independent risk factors for disease mortality in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. In the high risk group methotrexate, vinblastine, doxorubicin and cisplatin adjuvant chemotherapy contributed to improve subsequent mortality compared to gemcitabine and cisplatin or no adjuvant chemotherapy.
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Shirotake
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan. Electronic address: eiji-k@kb3.so-net.ne.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kikuchi
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ide
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Obata
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Katsura
authors.initials: K
authors.lastname: Hoshino
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Gou
authors.initials: G
authors.lastname: Kaneko
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hagiwara
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Kent
authors.initials: K
authors.lastname: Kanao
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Kodaira
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hara
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Oyama
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Momma
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Miyajima
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Nakagawa
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Department of Urology, Keio University School of Medicine (SS, EK, NT, KM, YM, HK, HI, JO, KH, GK, MH, TK, KK, AM, MO), Tokyo, Japan; Saiseikai Central Hospital (KM), Tokyo, Japan; Kyosai Tachikawa Hospital (HK), Tokyo, Japan; Kawasaki City Hospital (GK, SH), Tokyo, Japan; Musashino Yowakai Hospital (NT), Tokyo, Japan; Ogikubo Hospital (YM), Tokyo, Japan; Inagi City Hospital (HI), Tokyo, Japan; International Medical Center-Comprehensive Cancer Center, Saitama Medical University (SS, KK, MO), Saitama, Japan; Saitama City Hospital (NT), Saitama, Japan; National Hospital Organization Saitama Hospital (TM), Saitama, Japan; Irumagawa Hospital (TK), Saitama, Japan; National Hospital Organization Tochigi Medical Center, Tochigi (SH), Japan; Saiseikai Yokohamashi Tobu Hospital, Kanagawa (YN), Japan; Ichikawa General Hospital, Tokyo Dental College, Chiba (MH, KN), Japan.
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Oya
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007564:Japan; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014516:Ureteral Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents
keywords: adjuvant; carcinoma; chemotherapy; transitional cell; treatment outcome; urinary tract