title: A competitive cell fate switch.
abstract: Whereas tissue development and homeostasis depend on stem cell self-renewal and differentiation, the mechanisms that balance these processes remain incompletely understood. Pan et al. (2014) now show that competitive protein-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions within the Drosophila ovarian germline stem cell lineage.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Carreira-Rosario
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: michael.buszczak@utsouthwestern.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Buszczak
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002454:Cell Differentiation; D004331:Drosophila melanogaster / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D008297:Male; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D010447:Peptide Hydrolases