title: Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage.
abstract: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens.
authors.affiliation: Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States.
authors.forename: Chao
authors.initials: C
authors.lastname: Dai
authors.affiliation: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
authors.forename: Yun
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States.
authors.forename: Aaron
authors.initials: A
authors.lastname: Quinlan
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, United States.
authors.forename: Felicia
authors.initials: F
authors.lastname: Gaskin
authors.affiliation: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: BTsao@mednet.ucla.edu.
authors.forename: Betty P
authors.initials: BP
authors.lastname: Tsao
authors.affiliation: Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States. Electronic address: sf2e@virginia.edu.
authors.forename: Shu Man
authors.initials: SM
authors.lastname: Fu
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D051379:Mice