title: Changes in choroidal thickness after panretinal photocoagulation in patients with type 2 diabetes.
abstract: OBJECTIVE
  To investigate the changes in choroidal thickness (CT) in the macular and photocoagulated areas of patients with diabetic retinopathy after panretinal photocoagulation (PRP) using enhanced depth imaging optical coherence tomography.
  
  
  METHODS
  Patients with severe nonproliferative diabetic retinopathy or early proliferative diabetic retinopathy who needed PRP were included in this study. Choroidal thickness in the macula and the photocoagulated area was measured with enhanced depth imaging optical coherence tomography at baseline, 1 month, and 3 months after PRP.
  
  
  RESULTS
  The mean subfoveal CT increased significantly at 1 month (318.0 ± 76.4 μm, P < 0.001) and 3 months (317.4 ± 75.3 μm, P < 0.001) after PRP when compared with baseline (307.2 ± 70.7 μm). The mean CT in the photocoagulated area decreased significantly from 227.5 ± 45.0 μm to 206.9 ± 41.1 μm (P < 0.001) at 1 month and 206.0 ± 41.4 μm (P < 0.001) at 3 months after PRP. The subgroup analysis showed similar trends of CT changes in patients with or without diabetic macular edema. The mean change in CT was not statistically significantly correlated with the mean change in best-corrected visual acuity after PRP.
  
  
  CONCLUSIONS
  In patients with severe nonproliferative diabetic retinopathy or early proliferative diabetic retinopathy, the mean CT increased significantly in the macular area and decreased significantly in the photocoagulated area after PRP. The results might reflect a redistribution of choroidal blood flow, which may be critical for retinal metabolism.
authors.affiliation: *Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China; †Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China; and ‡Institute of Brain Science, Fudan University, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Keyan
authors.initials: K
authors.lastname: Wang
authors.forename: Gezhi
authors.initials: G
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009929:Organ Size; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology