title: Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese-a 4- and 13-year descriptive epidemiologic study.
abstract: Cross-sectional studies have shown age-related increases in blood docosahexaenoic and eicosapentaenoic acid and decreases in arachidonic acid. We describe serum docosahexaenoic, eicosapentaenoic, and arachidonic acid concentrations over 13 years (1997-2012) across four study waves and serum fatty acid composition over 4 years (2006-2012) between two study waves according to age groups by sex in the same subjects. We included 443 men and 435 women aged 40-79 years at baseline. Serum arachidonic acid concentrations increased in all sex and age groups over 13 years, and eicosapentaenoic or docosahexaenoic acid concentrations increased in males and females who were younger and middle-aged at baseline. Only serum arachidonic acid composition increased over 4 years in men and women who were 40-69 years at baseline, even after adjustment for arachidonic acid intake. These findings suggest a secular increase trend in serum arachidonic acid levels over 13 years among randomly selected community-dwelling middle-aged and elderly Japanese.
authors.affiliation: Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan. Electronic address: otsuka@ncgg.go.jp.
authors.forename: Rei
authors.initials: R
authors.lastname: Otsuka
authors.affiliation: Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan; Faculty of Human Life and Science, Doshisha Women׳s College of Liberal Arts, Teramachi Nishiiru, Imadegawa-dori, Kamigyo-ku, Kyoto, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Imai
authors.affiliation: Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan; Faculty of Health and Medical Sciences, Aichi Shukutoku University, 2-9 Katahira, Nagakute, Aichi, Japan.
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.affiliation: Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan; Graduate School of Nutritional Sciences, Nagoya University of Art and Science, 57 Takenoyama, Iwasaki, Nisshin, Aichi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D016718:Arachidonic Acid / Q000097:blood*; D003430:Cross-Sectional Studies; D003625:Data Collection; D004281:Docosahexaenoic Acids / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid
keywords: Arachidonic acid; Descriptive epidemiologic study; Docosahexaenoic acid; Eicosapentaenoic acid; Japanese