title: The future of carbon-based scaffolds in foot and ankle surgery.
abstract: Carbon may represent an alternative material suitable for future development as a soft-tissue substitute that potentially optimizes the biological and mechanical properties required for a graft product used in surgery. In addition, other modes of characterization such as 3-dimensional computational modeling may offer an insight into material performance in a biological environment. Further investigation is required to characterize and model the relationships between biological, mechanical, and design properties of this material to maximize its potential as a biomechanical scaffold and vehicle for delivering biologics that promote tissue repair and regeneration.
authors.affiliation: Department of Mechanical Engineering, University of Dayton, 300 College Park, Dayton, OH 45469, USA. Electronic address: jerry.czarnecki@gmail.com.
authors.forename: Jarema S
authors.initials: JS
authors.lastname: Czarnecki
authors.affiliation: Chemical and Materials Engineering, University of Dayton, 300 College Park, Dayton, OH 45469-0240, USA.
authors.forename: Khalid
authors.initials: K
authors.lastname: Lafdi
authors.affiliation: Biology, Center for Tissue Regeneration and Engineering (TREND), University of Dayton, 300 College Park, Dayton, OH 45469, USA.
authors.forename: Panagiotis A
authors.initials: PA
authors.lastname: Tsonis
mesh_terms: D002244:Carbon; D018929:Cell Culture Techniques; D055119:Elastic Modulus; D005347:Fibroblasts / Q000502:physiology; D005528:Foot / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D008422:Materials Testing; D016062:Porosity; D013718:Tensile Strength; D054457:Tissue Scaffolds
chemical_list: D002244:Carbon
keywords: Biologics; Biomaterials; Biomechanics; Carbon; Cell growth; Reconstruction; Scaffolds; Tissue