title: Efficacy and acceptance of a commercial Hoodia parviflora product for support of appetite and weight control in a consumer trial.
abstract: Species of Hoodia Sweet ex Decne., family Apocynaceae, a southern African succulent plant, have been recognized for their appetite suppressing properties. Products that support appetite and weight control have been developed in Israel from locally cultivated Hoodia spp. To study consumer acceptance, efficacy of, and tolerance for a frozen product based on whole aerial parts of Hoodia parviflora N.E. Br., we initiated and conducted this single-blind, randomized, placebo-controlled consumer trial. Volunteer participants ingested flavored 3 g frozen Hoodia or placebo cubes for 40 days. Subjects were weighed and measured and baseline body-mass index was determined. Adverse events were monitored and eight mild, transient, possible treatment-emergent events were reported. No moderate, severe, or chronic events were reported. On days 1, 10, and 40, subjects self-reported their perceptions of food consumption, hunger development, incidence and control of food cravings, and efficacy of the product. On day 40, the treatment group demonstrated a statistically significant decrease in measured quantitative parameters against the placebo and reported a positive perception of the product.
authors.affiliation: 1 Department of Medicine, Albert Einstein College of Medicine , New York, New York, USA .
authors.forename: Michael
authors.initials: M
authors.lastname: Landor
authors.forename: Ari
authors.initials: A
authors.lastname: Benami
authors.forename: Nitzan
authors.initials: N
authors.lastname: Segev
authors.forename: Beth
authors.initials: B
authors.lastname: Loberant
mesh_terms: D000328:Adult; D029062:Apocynaceae / Q000737:chemistry*; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D066249:Craving / Q000187:drug effects; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009519:New York City; D017060:Patient Satisfaction; D008517:Phytotherapy / Q000523:psychology*; D028321:Plant Preparations / Q000627:therapeutic use*; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D055105:Waist Circumference / Q000187:drug effects
chemical_list: D001067:Appetite Depressants; D028321:Plant Preparations
keywords: Hoodia parviflora; dietary herbal supplement; obesity; weight loss