title: Roseomics: a blank slate.
abstract: Recent technological advances have led to an explosion in the system-wide profiling of biological processes in the study of herpesvirus biology, herein referred to as '-omics'. In many cases these approaches have revealed novel virus-induced changes to host cell biology that can be targeted with new antiviral therapeutics. Despite these successes, -omics approaches are not widely applied in the study of roseoloviruses. Here we describe examples of how -omics studies have shaped our understanding of herpesvirus biology, and discuss how these approaches might be used to identify host and viral factors that mediate roseolovirus pathogenesis.
authors.affiliation: Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Nathaniel J
authors.initials: NJ
authors.lastname: Moorman
authors.affiliation: Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: murphye@ccf.org.
authors.forename: Eain A
authors.initials: EA
authors.lastname: Murphy
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods; D054884:Host-Pathogen Interactions; D006801:Humans; D055432:Metabolomics / Q000379:methods; D040901:Proteomics / Q000379:methods; D019211:Roseolovirus / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D049490:Systems Biology / Q000379:methods* / Q000639:trends; D014773:Virology / Q000379:methods / Q000639:trends