title: Synthesis, characterisation and antioxidant activity of luteolin-vanadium(II) complex.
abstract: The complex formation between luteolin (L) and vanadium(IV) oxide sulphate monohydrate (VOSO4·H2O) was examined under UV-visible, infra-red spectroscopy, mass spectroscopy and NMR techniques. The spectroscopic data indicated that luteolin reacts with vanadium oxide cation (VO(+2)) through 4-carbonyl-5-hydroxy chelation site in the two luteolin molecule. The free radical antioxidant activity of the complex with respect to the parent molecule was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and 2,2'-azinobis 3-ethylbenzothiazoline-6-sulphonic acid diammonium salt (ABTS) methods. It was observed that the free radical scavenging activity and ferric ion reducing potential of luteolin was increased after the formation of complex with vanadium oxide (VO(+2)) cation.
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India. Electronic address: souvikroy35@gmail.com.
authors.forename: Souvik
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Sougata
authors.initials: S
authors.lastname: Mallick
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Tania
authors.initials: T
authors.lastname: Chakraborty
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Ghosh
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Subhadip
authors.initials: S
authors.lastname: Manna
authors.affiliation: Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, West Bengal, India.
authors.forename: Sumana
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D047311:Luteolin / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D010087:Oxides / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts; D013055:Spectrophotometry, Infrared; D013451:Sulfonic Acids / Q000737:chemistry; D017968:Vanadium Compounds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D005609:Free Radicals; D010087:Oxides; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; D017968:Vanadium Compounds; C581824:vanadium dioxide; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D047311:Luteolin
keywords: Antioxidant activity; Luteolin–vanadium(II) complex; Radical scavenging activity; Spectral characterisation