title: [Optic neuritis in juvenile idiopathic arthritis patient].
abstract: Optic neuritis (ON) was rarely reported in juvenile idiopathic arthritis (JIA) patients, particularly in those under anti-tumor necrosis factor alpha blockage. However, to our knowledge, the prevalence of ON in JIA population has not been studied. Therefore, 5,793 patients were followed up at our University Hospital and 630 (11%) had JIA. One patient (0.15%) had ON and was reported herein. A 6-year-old male was diagnosed with extended oligoarticular JIA, and received naproxen and methotrexate subsequently replaced by leflunomide. At 11 years old, he was diagnosed with aseptic meningitis, followed by a partial motor seizure with secondary generalization. Brain magnetic resonance imaging (MRI) and electroencephalogram showed diffuse disorganization of the brain electric activity and leflunomide was suspended. Seven days later, the patient presented acute ocular pain, loss of acuity for color, blurred vision, photophobia, redness and short progressive visual loss in the right eye. A fundoscopic exam detected unilateral papilledema without retinal exudates. Orbital MRI suggested right ON. The anti-aquaporin 4 (anti-AQP4) antibody was negative. Pulse therapy with methylprednisolone was administered for five days, and subsequently with prednisone, he had clinical and laboratory improvement. In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required.
authors.affiliation: Unidade de Reumatologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil.
authors.forename: Daniela M R
authors.initials: DM
authors.lastname: Lourenço
authors.affiliation: Unidade de Reumatologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil.
authors.forename: Izabel M
authors.initials: IM
authors.lastname: Buscatti
authors.affiliation: Unidade do Adolescente, Departamento de Pediatria, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil.
authors.forename: Benito
authors.initials: B
authors.lastname: Lourenço
authors.affiliation: Unidade de Neurologia Pediátrica, Departamento de Neurologia, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Monti
authors.affiliation: Unidade de Neurologia Pediátrica, Departamento de Neurologia, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil.
authors.forename: José Albino
authors.initials: JA
authors.lastname: Paz
authors.affiliation: Unidade de Reumatologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil; Divisão de Reumatologia, Faculdade de Medicina da Universidade São Paulo, São Paulo, SP, Brasil. Electronic address: clovisaasilva@gmail.com.
authors.forename: Clovis A
authors.initials: CA
authors.lastname: Silva
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D002648:Child; D006801:Humans; D008297:Male; D009902:Optic Neuritis / Q000209:etiology*
keywords: Anticorpo antiaquaporina 4; Anti‐aquaporin 4 antibody; Artrite idiopática juvenil; Juvenile idiopathic arthritis; Neurite óptica; Optic neuritis