title: Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.
abstract: SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential enzyme required for signaling through multiple classes of immune recognition receptors. As a modulator of tumorigenesis, SYK has a bit of a schizophrenic reputation, acting in some cells as a tumor promoter and in others as a tumor suppressor. In many hematopoietic malignancies, SYK provides an important survival function and its inhibition or silencing frequently leads to apoptosis. In cancers of non-immune cells, SYK provides a pro-survival signal, but can also suppress tumorigenesis by restricting epithelial-mesenchymal transition, enhancing cell-cell interactions and inhibiting migration.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
authors.forename: Mariya O
authors.initials: MO
authors.lastname: Krisenko
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address: geahlen@purdue.edu.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Geahlen
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D063646:Carcinogenesis; D002450:Cell Communication; D002470:Cell Survival; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D000072377:Syk Kinase; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D011947:Receptors, Antigen, B-Cell; D025521:Tumor Suppressor Proteins; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase
keywords: Apoptosis; Epithelial–mesenchymal transition; Protein phosphorylation; SYK; Signal transduction; Spleen tyrosine kinase