title: QSTR modeling for predicting aquatic toxicity of pharmacological active compounds in multiple test species for regulatory purpose.
abstract: High concentrations of pharmacological active compounds (PACs) detected in global drinking water resources and their toxicological implications in aquatic life has become a matter of concern compelling for the development of reliable QSTRs (qualitative/quantitative structure-toxicity relationships) for their risk assessment. Robust QSTRs, such as decision treeboost (DTB) and decision tree forest (DTF) models implementing stochastic gradient boosting and bagging algorithms were established by experimental toxicity data of structurally diverse PACs in daphnia using molecular descriptors for predicting toxicity of new untested compounds in multiple test species. Developed models were rigorously validated using OECD recommended internal and external validation procedures and predictive power tested with external data of different trophic level test species (algae and fish). Classification QSTRs (DTB, DTF) rendered accuracy of 98.73% and 97.47%, respectively in daphnia and 84.38%, 85.94% (algae), 78.46% and 79.23% (fish). On the other hand, the regression QSTRs (DTB, DTF) yielded squared correlation coefficient values of 0.831, 0.852 (daphnia), 0.534, 0.556 (algae) and 0.620, 0.637 (fish). QSTRs developed in this study passed the OECD validation criteria and performed better than reported earlier for predicting toxicity of PACs, and can be used for screening the new untested compounds for regulatory purpose.
authors.affiliation: Academy of Scientific and Innovative Research, Anusandhan Bhawan, Rafi Marg, New Delhi 110 001, India; Environmental Chemistry Division, CSIR-Indian Institute of Toxicology Research, Post Box 80, Mahatma Gandhi Marg, Lucknow 226 001, India. Electronic address: kpsingh_52@yahoo.com.
authors.forename: Kunwar P
authors.initials: KP
authors.lastname: Singh
authors.affiliation: Academy of Scientific and Innovative Research, Anusandhan Bhawan, Rafi Marg, New Delhi 110 001, India; Environmental Chemistry Division, CSIR-Indian Institute of Toxicology Research, Post Box 80, Mahatma Gandhi Marg, Lucknow 226 001, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Gupta
authors.affiliation: KanbanSystems Pvt. Ltd., Laxmi Nagar, Delhi 110 092, India.
authors.forename: Nikita
authors.initials: N
authors.lastname: Basant
mesh_terms: D000465:Algorithms; D000818:Animals; D003621:Daphnia / Q000187:drug effects; D003663:Decision Trees; D060766:Drinking Water / Q000737:chemistry*; D005399:Fishes / Q000378:metabolism; D007928:Lethal Dose 50; D008956:Models, Chemical; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis; D013045:Species Specificity; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical
keywords: Decision tree forest; Decision treeboost; Multi-species; Pharmaceutically active compounds; QSTRs; Regulatory