title: Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation.
abstract: Three aromatic glycosides (1-3), two sulfur and nitrogen-containing compound glucosides (4, 5), and one flavonoid glycoside (6) were isolated from the leaves of Ixora undulata. Their structures were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structure 4 was further confirmed by single crystal X-ray diffraction analysis. Of the assayed compounds, 7, 11 and 12 showed strong inhibitory activity toward advanced glycation end-products formation with IC50 values of 86.0 μM, 76.6 μM and 98.6 μM, respectively.
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Amira Samir
authors.initials: AS
authors.lastname: Wanas
authors.affiliation: Department of Chemistry, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizuta
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Kamel
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan. Electronic address: hotsuka@hirsohima-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D004534:Egypt; D005419:Flavonoids / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D017127:Glycation End Products, Advanced; D006027:Glycosides
keywords: AGEs formation inhibitor; Ixora undulata; Rubiaceae; Sulfur and nitrogen-containing compound