title: Interstitial hyperthermia treatment of countercurrent vascular tissue: a comparison of Pennes, WJ and porous media bioheat models.
abstract: Development of appropriate heat transfer models to investigate the thermal behavior of living tissues has become increasingly important in simulations of cancer hyperthermia. In this paper, a review is initially presented of the more important general models developed for heat transfer description of perfused tissues. Comparisons are then made between Pennes' simplified Weinbaum and Jiji "WJ" and the more recent porous media "PM" bioheat models. For this purpose, a mathematical model is developed for the heat transfer in a cylindrical medium containing parallel counter-current pairs of small vessels with characteristics as much as possible similar to those of living tissues. The validity of the models is examined and confirmed using the Pennes in vivo experiments and one-dimensional analytical solutions. For consideration of interstitial hyperthermia treatment the smaller cylindrical zone with typical heat generation, is assumed in the center of the main cylinder. The numerical simulation results revealed that, despite difference in temperature distributions calculated by these three models at normal condition, the heat affected zone at hyperthermic condition predicted by all three models are similar.
authors.affiliation: Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: hassanpour@istt.ir.
authors.forename: Saied
authors.initials: S
authors.lastname: Hassanpour
authors.affiliation: Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Saboonchi
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology*; D001833:Body Temperature Regulation / Q000502:physiology; D005334:Fever / Q000503:physiopathology*; D006358:Hot Temperature; D006801:Humans; D008954:Models, Biological
keywords: Bioheat transfer; Interstitial hyperthermia; Pennes' equation; Porous media; Thermal modeling; WJ model