title: Serotonin transporter polymorphisms predict response inhibition in healthy volunteers.
abstract: Serotoninergic transmission is reliably implicated in inhibitory control processes. The aim of this study was to test the hypothesis if serotonin transporter polymorphisms mediate inhibitory control in healthy people. 141 healthy subjects, carefully screened for previous and current psychopathology, were genotyped for the 5-HTTLPR and rs25531 polymorphisms. Inhibitory control was ascertained with the Stop Signal Task (SST) from the Cambridge Neuropsychological Test Automated Battery (CANTAB). The triallelic gene model, reclassified and presented in a biallelic functional model, revealed a dose-dependent gene effect on SST performance with Individuals carrying the low expressive allele had inferior inhibitory control compared to high expressive carriers. This directly implicates serotonin transporter polymorphisms (5-HTTLPR plus rs25531) in response inhibition in healthy subjects.
authors.affiliation: Clinical Neuroscience Research Group, Department of Psychology, Oslo, Norway. Electronic address: n.i.landro@psykologi.uio.no.
authors.forename: N I
authors.initials: NI
authors.lastname: Landrø
authors.affiliation: Clinical Neuroscience Research Group, Department of Psychology, Oslo, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Jonassen
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge, UK.
authors.forename: L
authors.initials: L
authors.lastname: Clark
authors.affiliation: Section for Research, Department of Medical Biochemistry, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: K B Foss
authors.initials: KB
authors.lastname: Haug
authors.affiliation: Clinical Neuroscience Research Group, Department of Psychology, Oslo, Norway.
authors.forename: M
authors.initials: M
authors.lastname: Aker
authors.affiliation: Clinical Neuroscience Research Group, Department of Psychology, Oslo, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Bø
authors.affiliation: Section for Research, Department of Medical Biochemistry, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: J P
authors.initials: JP
authors.lastname: Berg
authors.affiliation: New York University, Department of Psychiatry, New York, USA.
authors.forename: A
authors.initials: A
authors.lastname: Neumeister
authors.affiliation: Department of Psychology, The Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: T C
authors.initials: TC
authors.lastname: Stiles
mesh_terms: D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Inhibitory control; Serotonin transporter