title: MIC gene polymorphism and haplotype diversity in Li nationality of Southern China.
abstract: Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Li population of 344 unrelated individuals. By using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequence-based typing (PCR-SBT), 17 MICA-sequence alleles and 5 MICA-STR (short tandem repeats, STR) alleles, as well as 17 MICB alleles were detected, among which MICA*010, MICA*A4 and MICB*005:02 were the most frequent alleles. In addition, linkage disequilibrium was investigated and the most common two-locus haplotypes were MICB*005:02-MICA*010 and MICB*008-MICA*002:01. These results present informative genetic markers for the investigation of possible origins and the evolution of MHC class I haplotypes in the Li population.
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, 410078, China.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: W
authors.initials: W
authors.lastname: Yang
authors.forename: E
authors.initials: E
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Gong
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Luo
authors.forename: X B
authors.initials: XB
authors.lastname: Wei
authors.forename: P
authors.initials: P
authors.lastname: Yu
mesh_terms: D000483:Alleles; D002681:China; D005006:Ethnicity; D005787:Gene Frequency; D005819:Genetic Markers; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen
keywords: Li nationality; MHC class I chain-related gene; gene polymorphism; haplotype diversity