title: Dibenzazepines and dibenzoxazepines as sodium channel blockers.
abstract: We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
authors.affiliation: Discovery Research, Purdue Pharma LP, 6 Cedarbrook Drive, Cranbury, NJ 08512, United States.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lynch
authors.forename: Laykea
authors.initials: L
authors.lastname: Tafesse
authors.forename: Kevin
authors.initials: K
authors.lastname: Carlin
authors.forename: Parijat
authors.initials: P
authors.lastname: Ghatak
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Kyle
mesh_terms: D000818:Animals; D003984:Dibenzazepines / Q000737:chemistry* / Q000494:pharmacology; D003989:Dibenzoxazepines / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008862:Microsomes, Liver / Q000187:drug effects / Q000502:physiology; D062556:NAV1.7 Voltage-Gated Sodium Channel / Q000502:physiology*; D051381:Rats; D026941:Sodium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D003984:Dibenzazepines; D003989:Dibenzoxazepines; D062556:NAV1.7 Voltage-Gated Sodium Channel; D026941:Sodium Channel Blockers; C527817:dibenzazepine