title: Effect of glycounits on the antimicrobial properties and toxicity behavior of polymers based on quaternized DMAEMA.
abstract: Polymers with quaternary ammonium groups such as quaternized poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMAQ) have been used as antimicrobial agents because of their demonstrated good antimicrobial activities against a huge number and types of microbes, although their cytotoxicity is also well-known. In this work block copolymers based on PDMAEMAQ were synthesized containing hydrophobic segments of poly(butyl methacrylate) to improve the antimicrobial activity and glycomonomer units with the aim of decreasing the cytotoxicity of the polymers. Hydrophobic butyl methacrylate (BMA) blocks were chain extended by statistical and block copolymers of DMAEMA and 2-{[(d-glucosamin-2-N-yl)carbonylethyl methacrylate (HEMAGl) glycomonomer of different compositions. In order to find the balance between antimicrobial activity and cytotoxicity, the selectivity index of each polymer was obtained from minimum inhibitory concentrations (MIC) and white and red blood cells toxicity measurements.
authors.affiliation: Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Álvarez-Paino
authors.forename: Alexandra
authors.initials: A
authors.lastname: Muñoz-Bonilla
authors.forename: Fátima
authors.initials: F
authors.lastname: López-Fabal
authors.forename: José L
authors.initials: JL
authors.lastname: Gómez-Garcés
authors.forename: Johan P A
authors.initials: JP
authors.lastname: Heuts
authors.forename: Marta
authors.initials: M
authors.lastname: Fernández-García
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions; D007962:Leukocytes / Q000187:drug effects; D008689:Methacrylates / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009757:Nylons / Q000138:chemical synthesis / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D008689:Methacrylates; D009757:Nylons; D011108:Polymers; C407037:poly(2-(dimethylamino)ethyl methacrylate)