title: Predictive and prognostic value of circulating tumor cell detection in lung cancer: a clinician's perspective.
abstract: There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; Macarthur Clinical School, University of Western Sydney, Campbelltown 2560, Australia; Department of Medical Oncology, Campbelltown Hospital, Campbelltown 2560, Australia. Electronic address: Annette.Tognela@sswahs.nsw.gov.au.
authors.forename: Annette
authors.initials: A
authors.lastname: Tognela
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Spring
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia.
authors.forename: Therese
authors.initials: T
authors.lastname: Becker
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia.
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Caixeiro
authors.affiliation: Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia.
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Bray
authors.affiliation: Department of Medical Oncology, Campbelltown Hospital, Campbelltown 2560, Australia; Sydney Medical School, University of Sydney, Camperdown 2006, Australia.
authors.forename: Po Yee
authors.initials: PY
authors.lastname: Yip
authors.affiliation: Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Chua
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia.
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia; Macarthur Clinical School, University of Western Sydney, Campbelltown 2560, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: de Souza
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001681:Biological Assay; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002452:Cell Count; D002469:Cell Separation / Q000379:methods; D042241:Early Diagnosis; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D059010:Single-Cell Analysis / Q000295:instrumentation / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Biomarkers; Circulating tumor cells; Lung cancer; Non-small cell; Small cell