title: Insight into reduction of obacunone, and their ester derivatives as insecticidal agents against Mythimna separata Walker.
abstract: Here we have prepared a series of ester compounds of obacunone, a naturally occurring limonoid, isolated from plants such as Citrus and Dictamnus angustifolius. Their insecticidal activity was evaluated at 1 mg/mL against the pre-third-instar larvae of oriental armyworm (Mythimna separata Walker), a typical lepidopteran pest. When obacunone reacted with NaBH₄, the ratio of two reduction products, C7α-hydroxyobacunone (2) and C7β-hydroxyobacunone (3), was related to the reaction mixing solvents. C7α-Propionyloxybacunone (4b) and C7β-(n)heptanoyloxybacunone (5g) exhibited the more promising insecticidal activity than their precursor obacunone and toosendanin.
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yu
authors.forename: Guodong
authors.initials: G
authors.lastname: Ding
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhi
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D001584:Benzoxepins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D004952:Esters; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031586:Melia azedarach; D009036:Moths / Q000187:drug effects*; D010084:Oxidation-Reduction
chemical_list: D001584:Benzoxepins; D004365:Drugs, Chinese Herbal; D004952:Esters; D007306:Insecticides; D036701:Limonins; C067207:obacunone