title: Bacterial histidine kinases as novel antibacterial drug targets.
abstract: Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.
authors.affiliation: Host-Microbe Interactomics, Wageningen University , De Elst 1, 6708 WD Wageningen, The Netherlands.
authors.forename: Agnieszka E
authors.initials: AE
authors.lastname: Bem
authors.forename: Nadya
authors.initials: N
authors.lastname: Velikova
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Pellicer
authors.forename: Peter van
authors.initials: Pv
authors.lastname: Baarlen
authors.forename: Alberto
authors.initials: A
authors.lastname: Marina
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Wells
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D001424:Bacterial Infections / Q000382:microbiology; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D000071677:Histidine Kinase; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D000071677:Histidine Kinase