title: Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Women diagnosed with PCOS and age-matched healthy controls with regular menses and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese >30 kg/m2 and non-obese <25 kg/m2). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured.
  
  
  RESULTS
  Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P < .0001). Women with PCOS had significantly higher MIF levels (group A, 48.6 ± 9.9 mg/ml; group B, 35.2 ± 6.0 ng/ml) as compared to controls (group C, 13.5 ± 6.0 ng/ml; group D, 12.0 ± 4.3 ng/dl; P < .0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P < .05).
  
  
  CONCLUSIONS
  Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Jorly
authors.initials: J
authors.lastname: Mejia-Montilla
authors.affiliation: Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
authors.forename: Melchor
authors.initials: M
authors.lastname: Álvarez-Mon
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela. Electronic address: sippenbauch@gmail.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Reyna-Villasmil
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Duly
authors.initials: D
authors.lastname: Torres-Cepeda
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Joel
authors.initials: J
authors.lastname: Santos-Bolívar
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Nadia
authors.initials: N
authors.lastname: Reyna-Villasmil
authors.affiliation: Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Ismael
authors.initials: I
authors.lastname: Suarez-Torres
authors.affiliation: Laboratorio de Investigación y Desarrollo en Nutrición, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bravo-Henríquez
mesh_terms: D000328:Adult; D000735:Androstenedione / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D009765:Obesity / Q000097:blood*; D010053:Ovary / Q000000981:diagnostic imaging; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008263:Macrophage Migration-Inhibitory Factors; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human
keywords: Factor inhibidor de la migración de macrófagos; Macrophage migration inhibitory factor; Obesidad; Obesity; Polycystic ovary syndrome; Síndrome de ovarios poliquísticos