title: Amine-linked diquercitols as new α-glucosidase inhibitors.
abstract: Two new diastereomeric amine-linked diquercitols 7 and 8 were synthesized by reductive amination of ketoquercitol 4 and epimeric aminoquercitols 3 and 6. The ketone and amines were successfully prepared, without the formation of byproducts, from naturally available (+)-proto-quercitol (1). The amine-linked diquercitols showed inhibitory effect against α-glucosidases with more pronounced potency than their original aminoquercitol monomers.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Wisuttaya
authors.initials: W
authors.lastname: Worawalai
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sumrit
authors.initials: S
authors.lastname: Wacharasindhu
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: preecha.p@chula.ac.th.
authors.forename: Preecha
authors.initials: P
authors.lastname: Phuwapraisirisan
mesh_terms: D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D000520:alpha-Glucosidases
keywords: Aminocyclitol; Diabetes; Glucosidase; Quercitol; Reductive amination