title: Peripheral drug-eluting technology.
abstract: This article reviews current knowledge and applications of drug-eluting devices in the treatment of peripheral arterial disease. The authors briefly report on the performance of plain old balloon angioplasty and bare metal stents in femoro-popliteal and below-the-knee lesions. This article explains the rationale behind the development of drug-eluting devices and describes the main technical features of currently available drug-eluting stents and drug-coated balloons. Dedicated sections discuss the results of trials investigating the potential benefits of these devices used in femoro-popliteal and infra-popliteal arterial vascular beds. Finally, ongoing studies and potential novel applications of drug-eluting technologies in other vascular beds are mentioned.
authors.affiliation: Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Franzone
authors.affiliation: Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy. Electronic address: geko50@hotmail.com.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Stabile
authors.affiliation: Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Trimarco
authors.affiliation: Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Esposito
mesh_terms: D000497:Alloys; D000800:Angioplasty, Balloon; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D054855:Drug-Eluting Stents; D019317:Evidence-Based Medicine; D005263:Femoral Artery; D006801:Humans; D007511:Ischemia / Q000628:therapy; D007866:Leg / Q000098:blood supply; D008670:Metals; D011150:Popliteal Artery; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000497:Alloys; D008670:Metals; C013616:nitinol
keywords: Below-the-knee; Drug-coated balloons; Drug-eluting balloon; Drug-eluting stents; Femoropopliteal; In-stent restenosis; Peripheral artery disease; Restenosis