title: Epigenomic regulation of host-microbiota interactions.
abstract: The trillions of beneficial commensal microorganisms that normally reside in the gastrointestinal tract have emerged as a critical source of environmentally-derived stimuli that can impact health and disease. However, the underlying cellular and molecular mechanisms that recognize commensal bacteria-derived signals and regulate mammalian homeostasis are just beginning to be defined. Highly coordinated epigenomic modifications allow mammals to alter the transcriptional program of a cell in response to environmental cues. These modifications may play a key role in regulating the dynamic relationship between mammals and their microbiota. We review recent advances in understanding the interplay between the microbiota and mammalian epigenomic pathways, and highlight emerging findings that implicate a central role for histone deacetylases (HDACs) in orchestrating host-microbiota interactions.
authors.affiliation: Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: theresa.alenghat@cchmc.org.
authors.forename: Theresa
authors.initials: T
authors.lastname: Alenghat
authors.affiliation: Weill Cornell Medical College, Cornell University, New York, NY 10022, USA. Electronic address: dartis@med.cornell.edu.
authors.forename: David
authors.initials: D
authors.lastname: Artis
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000378:metabolism; D060833:Cellular Microenvironment; D044127:Epigenesis, Genetic; D057890:Epigenomics; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology*; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D006655:Histone Deacetylases / Q000378:metabolism; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D064307:Microbiota
chemical_list: D006655:Histone Deacetylases