title: Were the wrong cells studied?
abstract: Peripheral blood lymphocytes (PBL) studying the effects of dioxins and dioxin-like compounds in vitro is not correct. Peripheral lymphocytes in general (Th1, Th2) do not have an Ah-receptor. Polymorphonuclear leucocytes (PMN's) are more logical to use.
authors.affiliation: University of Amsterdam, Emma Children's Hospital-AMC, Dept. of Pulmonology, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands.
authors.forename: Janna
authors.initials: J
authors.lastname: Koppe
authors.affiliation: Department of Paediatrics and Neonatology, Westfriesgasthuis, Hoorn, The Netherlands.
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Ten Tusscher
mesh_terms: D000818:Animals; D004147:Dioxins / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D013154:Spleen / Q000187:drug effects*
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants
keywords: Ah-receptor; Dioxin; Dioxin-like compound; Lymphocytes; Polymorphonuclear leucocytes; Toxic equivalent factor (TEF)