title: Vascular effects of the Mediterranean diet part I: anti-hypertensive and anti-thrombotic effects.
abstract: This review summarizes available evidence on the beneficial effects of inorganic nitrates and the monounsaturated fatty acid (MUFA) oleic acid, largely contained in Mediterranean diet, on blood pressure and coagulation activity. Inorganic nitrate. Normal vascular function requires NO production from the 1-arginine-NO synthase (NOS) pathway. This process is defective in conditions of local hypoxia, and here nitrite can substitute for 1-arginine-NOS derived NO. In this context, NO generation from the nitrate-nitrite-NO pathway mostly derived from green leafy vegetables appears to be an alternative source for NOS-dependent NO production, ensuring NO bioavailability also in situations when the endogenous 1-arginine/NO synthase pathway is dysfunctional or physiologically reduced in local hypoxic conditions. Olive oil and oleic acid. In addition to effects on lipoprotein metabolism and oxidation, the beneficial effects of oleic acid occur also on coagulation activity, namely on coagulation factor VII (FVII). Normally, a substantial increase of FVII coagulant activity (FVIIc) occurs within 2-3h after a fatty meal and persists for several hours thereafter. When a background diet high in MUFA is consumed, a lower post-prandial increase of FVIIc takes place.
authors.affiliation: Dept. of Medical and Surgical Science, Section on Geriatrics and Internal Medicine, University of Foggia, Italy. Electronic address: cristiano.capurso@unifg.it.
authors.forename: C
authors.initials: C
authors.lastname: Capurso
authors.affiliation: National Research Council (CNR), Institute of Clinical Physiology, Lecce, Italy. Electronic address: marika.massaro@tiscali.it.
authors.forename: M
authors.initials: M
authors.lastname: Massaro
authors.affiliation: National Research Council (CNR), Institute of Clinical Physiology, Lecce, Italy. Electronic address: egeria.scoditti@ifc.cnr.it.
authors.forename: E
authors.initials: E
authors.lastname: Scoditti
authors.affiliation: Dept. of Medical and Surgical Science, Section on Geriatrics and Internal Medicine, University of Foggia, Italy. Electronic address: gianluigi.vendemiale@unifg.it.
authors.forename: G
authors.initials: G
authors.lastname: Vendemiale
authors.affiliation: Faculty of Medicine, Section of Geriatrics and Gerontology, University of Bari, Italy. Electronic address: a.capurso@alice.it.
authors.forename: A
authors.initials: A
authors.lastname: Capurso
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D038441:Diet, Mediterranean; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D006801:Humans; D009566:Nitrates / Q000494:pharmacology; D019301:Oleic Acid / Q000494:pharmacology; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D005229:Fatty Acids, Monounsaturated; D009566:Nitrates; D019301:Oleic Acid
keywords: Cardiovascular risk; Factor VII; Leafy vegetables; Mediterranean diet; Nitrates