title: PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma.
abstract: Glioma is the most aggressive brain tumour, resulting in death often within 1-2 years. Current treatment strategies involve surgical resection followed by chemoradiation therapy. Despite continuing improvements in the delivery of adjuvant therapies, there has not been a dramatic increase in survival for glioma. Molecular imaging techniques have become central in the development of new therapeutic strategies in recent years. The multimodal imaging technology of positron emission tomography/magnetic resonance imaging (PET/MRI) has recently been realised on a preclinical scale and the effect of this technology is starting to be observed in preclinical drug development for glioma. Here, we propose that PET/MRI will play an integral part in the development of new diagnostic and therapeutic strategies for glioma.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Puttick
authors.affiliation: CSIRO - The Australian e-Health Research Centre, Level 5, UQ Health Science Building, RBWH, Herston, QLD 4029, Australia; School of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bell
authors.affiliation: CSIRO - The Australian e-Health Research Centre, Level 5, UQ Health Science Building, RBWH, Herston, QLD 4029, Australia.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Dowson
authors.affiliation: CSIRO - The Australian e-Health Research Centre, Level 5, UQ Health Science Building, RBWH, Herston, QLD 4029, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Rose
authors.affiliation: School of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia; Genesis Cancer Care, Lake Macquarie Private Hospital, 36 Pacific Highway, Gateshead, NSW 2290, Australia; Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD 4006, Australia. Electronic address: mike.fay@cancer.com.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Fay
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy; D005910:Glioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography