title: Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment.
abstract: CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents.
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. alawrenczyk@calibr.org.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lawrenczyk
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. seilkim@usc.edu.
authors.forename: Seil
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. xiangshw@usc.edu.
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rxiong@usc.edu.
authors.forename: Ran
authors.initials: R
authors.lastname: Xiong
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. weiming.yuan@usc.edu.
authors.forename: Weiming
authors.initials: W
authors.lastname: Yuan