title: Helicobacter pylori infection amongst Arab Israeli women with hyperemesis gravidarum--a prospective, controlled study.
abstract: OBJECTIVE
  Helicobacter pylori has been associated with hyperemesis gravidarum in some geographical regions. The prevalence of H. pylori in Arab Israeli women in the Upper Galilee and its association with hyperemesis gravidarum has not been studied previously. We aimed to examine if hyperemesis gravidarum is associated with H. pylori in this population.
  
  
  METHODS
  Subjects with hyperemesis gravidarum carrying a singleton fetus were recruited prospectively. Women with an uncomplicated pregnancy served as controls. All patients underwent (13)C-urea breath testing to assess for H. pylori infection.
  
  
  RESULTS
  A total of 72 subjects, including 24 patients with hyperemesis gravidarum and 48 controls, aged 28.8±5.3 years, were included. H. pylori infection was identified in 75.0% (18/24) of cases and 60.4% (29/48) of controls (p=not significant). H. pylori infection did not correlate with age, fetal sex, or the number of previous pregnancies (p=not significant).
  
  
  CONCLUSIONS
  H. pylori does not seem to increase the likelihood of hyperemesis gravidarum in Arab Israeli women. However, given the high background prevalence of H. pylori in this population, a larger study is required to corroborate these findings. (MOH20110066).
authors.affiliation: Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinski Street, Petah Tikva, Israel 49100; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: dboltin@gmail.com.
authors.forename: Doron
authors.initials: D
authors.lastname: Boltin
authors.affiliation: Gastroenterology Laboratory, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
authors.forename: Tsachi Tsadok
authors.initials: TT
authors.lastname: Perets
authors.affiliation: Department of Pediatric Gastroenterology, St Vincent French Hospital, Nazareth, Israel; Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
authors.forename: Sami Abu
authors.initials: SA
authors.lastname: Elheiga
authors.affiliation: Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel; Department of Obstetrics and Gynecology, St Vincent French Hospital, Nazareth, Israel.
authors.forename: Asher
authors.initials: A
authors.lastname: Sharony
authors.affiliation: Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinski Street, Petah Tikva, Israel 49100.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Niv
authors.affiliation: Department of Pediatric Gastroenterology, St Vincent French Hospital, Nazareth, Israel; Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
authors.forename: Hussein
authors.initials: H
authors.lastname: Shamaly
authors.affiliation: Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinski Street, Petah Tikva, Israel 49100.
authors.forename: Ram
authors.initials: R
authors.lastname: Dickman
mesh_terms: D000328:Adult; D018912:Arabs; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology; D016480:Helicobacter pylori; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000150:complications* / Q000208:ethnology; D007557:Israel / Q000208:ethnology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000208:ethnology; D015995:Prevalence; D011446:Prospective Studies
keywords: Helicobacter pylori; Hyperemesis gravidarum; Pregnancy; Vomiting