title: Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.
abstract: Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.
authors.affiliation: Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico.
authors.forename: Ivette
authors.initials: I
authors.lastname: Bañuelos-Cabrera
authors.affiliation: Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico.
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Valle-Dorado
authors.affiliation: Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico.
authors.forename: Blanca Irene
authors.initials: BI
authors.lastname: Aldana
authors.affiliation: Unit of Medical Research in Neurological Diseases, National Medical Center, Mexico City, Mexico.
authors.forename: Sandra Adela
authors.initials: SA
authors.lastname: Orozco-Suárez
authors.affiliation: Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico. Electronic address: lrocha@cinvestav.mx.
authors.forename: Luisa
authors.initials: L
authors.lastname: Rocha
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology*; D006632:Histamine / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008407:Mast Cells / Q000378:metabolism; D010300:Parkinson Disease / Q000503:physiopathology*
chemical_list: D006632:Histamine
keywords: Blood–brain barrier; Histamine; Mast cells; Neuroinflammation; Neurological disorders