title: Cholesterol and fat lowering with hydrophobic polysaccharide derivatives.
abstract: Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
authors.affiliation: Department of Carbohydrate Chemistry and Technology, ICT Prague, Technická 5, Prague 6 Dejvice 166 28, Czech Republic. Electronic address: copikovj@vscht.cz.
authors.forename: Jana
authors.initials: J
authors.lastname: Čopíková
authors.affiliation: Department of Carbohydrate Chemistry and Technology, ICT Prague, Technická 5, Prague 6 Dejvice 166 28, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Taubner
authors.affiliation: Department of Carbohydrate Chemistry and Technology, ICT Prague, Technická 5, Prague 6 Dejvice 166 28, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Tůma
authors.affiliation: Department of Carbohydrate Chemistry and Technology, ICT Prague, Technická 5, Prague 6 Dejvice 166 28, Czech Republic.
authors.forename: Andriy
authors.initials: A
authors.lastname: Synytsya
authors.affiliation: Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Přátelství 815, Prague 10 Uhříněves 104 00, Czech Republic.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Dušková
authors.affiliation: Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Přátelství 815, Prague 10 Uhříněves 104 00, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Marounek
mesh_terms: D000327:Adsorption; D002152:Calorimetry, Differential Scanning; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D020355:Cholates / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D011134:Polysaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020355:Cholates; D011134:Polysaccharides; D002784:Cholesterol
keywords: Cholate and cholesterol sorption; Hydrophobically modified polysaccharides; Structure; Thermal analysis