title: Technoeconomic analysis of large scale production of pre-emergent Pseudomonas fluorescens microbial bioherbicide in Canada.
abstract: The study presents an ex ante technoeconomic analysis of commercial production of Pseudomonas fluorescens BRG100 bioherbicide in Canada. An engineering economic model is designed in SuperPro Designer® to investigate capital investment scaling and profitability. Total capital investment for a stand-alone BRG100 fermentation plant at baseline capacity (two 33,000L fermenters; 3602tonnesannum(-1)) is $17.55million. Total annual operating cost is $14.76million. Raw materials account for 50% of operating cost. The fermentation plant is profitable over wide operating scale, evaluated over a range of BRG100 prices and costs of capital. Smaller plants require higher NPV breakeven prices. However, larger plants are more sensitive to changes in the cost of capital. Unit production costs decrease as plant capacity increases, indicating scale economies. A plant operating for less than one year approaches positive NPV for periods as low as 2months. These findings can support bioherbicide R&D investment and commercialization strategies.
authors.affiliation: Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada. Electronic address: Edmund.Mupondwa@agr.gc.ca.
authors.forename: Edmund
authors.initials: E
authors.lastname: Mupondwa
authors.affiliation: Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
authors.forename: Susan
authors.initials: S
authors.lastname: Boyetchko
authors.affiliation: Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
authors.forename: Russell
authors.initials: R
authors.lastname: Hynes
authors.affiliation: Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
authors.forename: Jon
authors.initials: J
authors.lastname: Geissler
mesh_terms: D019149:Bioreactors / Q000191:economics / Q000382:microbiology; D002170:Canada; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D005285:Fermentation; D006540:Herbicides / Q000191:economics / Q000378:metabolism; D007449:Investments; D018803:Models, Economic; D011551:Pseudomonas fluorescens / Q000254:growth & development* / Q000378:metabolism; D012106:Research / Q000191:economics
chemical_list: D006540:Herbicides
keywords: Bioherbicide bacterial fermentation; Bioprocess design; Capital investment; Net present value; Technoeconomic