title: Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health.
abstract: This paper provides an overview of the Saguenay Youth Study (SYS) and its parental arm. The overarching goal of this effort is to develop trans-generational models of developmental cascades contributing to the emergence of common chronic disorders, such as depression, addictions, dementia and cardio-metabolic diseases. Over the past 10 years, we have acquired detailed brain and cardio-metabolic phenotypes, and genome-wide genotypes, in 1029 adolescents recruited in a population with a known genetic founder effect. At present, we are extending this dataset to acquire comparable phenotypes and genotypes in the biological parents of these individuals. After providing conceptual background for this work (transactions across time, systems and organs), we describe briefly the tools employed in the adolescent arm of this cohort and highlight some of the initial accomplishments. We then outline in detail the phenotyping protocol used to acquire comparable data in the parents.
authors.affiliation: Rotman Research Institute, University of Toronto, Toronto, Canada. Electronic address: tpaus@research.baycrest.org.
authors.forename: T
authors.initials: T
authors.lastname: Paus
authors.affiliation: Hospital for Sick Children, University of Toronto, Toronto, Canada. Electronic address: zdenka.pausova@sickkids.ca.
authors.forename: Z
authors.initials: Z
authors.lastname: Pausova
authors.affiliation: McGill University Health Centre, McGill University, Montreal, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Abrahamowicz
authors.affiliation: Community Genomic Medicine Centre, Department of Medicine, Université de Montréal, Chicoutimi, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Gaudet
authors.affiliation: Montreal Neurological Institute, McGill University, Montreal, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Leonard
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
authors.forename: G B
authors.initials: GB
authors.lastname: Pike
authors.affiliation: Department of Health Sciences, University of Quebec in Chicoutimi, Chicoutimi, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Richer
mesh_terms: D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism / Q000235:genetics*; D001823:Body Composition / Q000235:genetics; D001921:Brain / Q000503:physiopathology*; D002170:Canada; D002318:Cardiovascular Diseases / Q000235:genetics*; D002648:Child; D002908:Chronic Disease; D003071:Cognition; D017281:Cost of Illness; D003704:Dementia / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D006233:Persons with Disabilities; D005260:Female; D018703:Founder Effect; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008136:Longevity; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D010290:Parents; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics* / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000235:genetics
keywords: Addiction; Adolescence; Brain; MRI; Mental health; Middle age