title: The disruptive effects of methamphetamine on delayed-matching-to-sample performance reflect proactive interference and are reduced by SCH23390.
abstract: Different drugs produce different patterns of impairment on delayed matching-to-sample tasks. For example, (+/-)3,4-methylenedioxymethamphetamine (MDMA) produces an increase in proactive interference. That is, subjects are less accurate when they are required to make a response different to the one they made on the immediately previous trial. The current study assessed whether methamphetamine also produces this particular pattern of disruption in delayed matching-to-sample performance in rats. Methamphetamine primarily reduced accuracy on trials where the correct response differed from the one made on the previous trial. Thus methamphetamine, like MDMA and other stimulant-based drugs of abuse, increased proactive interference. This impairment was reduced by prior administration of the dopamine D1 antagonist SCH23390. These results further extend a general conclusion that a range of stimulant-based drugs may disrupt working memory function indirectly via a tendency to repeat previously made responses and that this disruption is related to D1 receptor activity.
authors.affiliation: Victoria University of Wellington, School of Psychology, PO Box 600, Wellington, New Zealand. Electronic address: anne.macaskill@vuw.ac.nz.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Macaskill
authors.affiliation: Victoria University of Wellington, School of Psychology, PO Box 600, Wellington, New Zealand.
authors.forename: Catherine C
authors.initials: CC
authors.lastname: Harrow
authors.affiliation: Victoria University of Wellington, School of Psychology, PO Box 600, Wellington, New Zealand.
authors.forename: David N
authors.initials: DN
authors.lastname: Harper
mesh_terms: D019969:Amphetamine-Related Disorders / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D008694:Methamphetamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000502:physiology
chemical_list: D001552:Benzazepines; D000697:Central Nervous System Stimulants; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D008694:Methamphetamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine
keywords: Delayed matching-to-sample; Memory; Methamphetamine; Proactive interference; Rats