title: In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.
abstract: Plazomicin is a next-generation aminoglycoside with a potentially unique set of clinical characteristics compared with other aminoglycosides. This study assessed the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plazomicin against 15 clinical isolates as well as three reference strains representing Brucella abortus, Brucella melitensis and Brucella suis. These data were compared with those obtained for six other aminoglycosides and two aminocyclitols. Plazomicin and gentamicin were the only drugs demonstrating bactericidal activity towards two of the three Brucella spp., whilst plazomicin was the only drug exhibiting bactericidal activity against B. suis. This is the first study to assess the bactericidal nature of plazomicin against Brucella spp. in vitro.
authors.affiliation: Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Ames, IA 50010, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Olsen
authors.affiliation: Department of Biomedical Sciences, Iowa State University, College of Veterinary Medicine, 2028 Vet Med, Ames, IA 50011, USA. Electronic address: stevec@iastate.edu.
authors.forename: Steve A
authors.initials: SA
authors.lastname: Carlson
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002003:Brucella abortus / Q000187:drug effects* / Q000302:isolation & purification; D017347:Brucella melitensis / Q000187:drug effects* / Q000302:isolation & purification; D041021:Brucella suis / Q000187:drug effects* / Q000302:isolation & purification; D002006:Brucellosis / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects*; D012853:Sisomicin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C550938:plazomicin; D012853:Sisomicin
keywords: Aminoglycoside; Antibiotic; Brucella