title: Intensity-modulated whole pelvic radiotherapy provides effective dosimetric outcomes for cervical cancer treatment with lower toxicities.
abstract: OBJECTIVE
  To compare the efficacy of intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy for cervical cancer treatment.
  
  
  METHODS
  Whole pelvis intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy plans were designed for 16 patients with stage IIB cervical cancer, each using the prescribed dose of 50.4 Gy/28 fractions. Dose-volume histograms of the target volume and organs at risk were evaluated.
  
  
  RESULTS
  Compared to the 3D conformal and conventional radiotherapy plans, the intensity-modulated radiotherapy plan demonstrated superior conformal treatment. The mean planning target volume dose of all three plans reached the target effective therapeutic dose. The planning target volume dose of the intensity-modulated radiotherapy plan was significantly higher than that of either the three-dimensional conformal radiotherapy or conventional radiotherapy plan (P<0.05). When more than 30 Gy was administered in intensity-modulated radiotherapy, organs at risk including the small intestine, rectum, bladder, and bone marrow received a significantly reduced volume of radiation. In comparison of the average planning target volume doses, significant volume reductions in irradiation of organs at risk were obtained with full bladders.
  
  
  CONCLUSIONS
  An intensity-modulated radiotherapy plan with appropriate margins encompassing the primary tumour and potential microscopic pelvic disease reduces the dose to organs at risk without compromising target coverage. Intensity-modulated radiotherapy is an appropriate definitive treatment for patients with cervical cancer.
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, 281, Jixi Road, Hefei, Anhui 230022, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, 281, Jixi Road, Hefei, Anhui 230022, People's Republic of China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, 281, Jixi Road, Hefei, Anhui 230022, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, 281, Jixi Road, Hefei, Anhui 230022, People's Republic of China. Electronic address: sunguoping@ahmu.edu.cn.
authors.forename: G
authors.initials: G
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010388:Pelvis; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
keywords: Bladder filling; Cancer du col utérin; Cervical cancer; Intensity-modulated radiotherapy (IMRT); Radiothérapie conformationnelle avec modulation d’intensité; Remplissage vésical