title: Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks.
abstract: Growth hormone-releasing hormone (GHRH) is well known as a stimulator of growth hormone (GH) secretion. GHRH not only stimulates GH release but also modifies feeding behavior and energy homeostasis in rodents. In chickens (Gallus gallus domesticus), on the other hand, two types of GHRH, namely, chicken GHRH (cGHRH) and cGHRH-like peptide (cGHRH-LP), have been identified. The purpose of the present study was to investigate the effect of central injection of cGHRH and cGHRH-LP on feeding behavior in chicks. Intracerebroventricular (ICV) injection of both cGHRH and cGHRH-LP (0.04 to 1 nmol) significantly decreased food intake without any abnormal behavior in chicks. Furthermore, the feeding-inhibitory effect was not abolished by co-injection of the antagonist for pituitary adenylate cyclase-activating polypeptide (PACAP) or corticotropin-releasing hormone (CRH) receptors, suggesting that the anorexigenic effect of cGHRH and cGHRH-LP might not be related to the PACAP and CRH systems in the brain of chicks. Finally, 24-h food deprivation increased mRNA expression of cGHRH but not cGHRH-LP in the diencephalon. These results suggest that central cGHRH is related to inhibiting feeding behavior and energy homeostasis in chicks.
authors.affiliation: Faculty of Agriculture, Department of Agrobiological Science, Ehime University, Matsuyama 790-8566, Japan. Electronic address: tetsu@agr.ehime-u.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
authors.affiliation: Faculty of Agriculture, Department of Agrobiological Science, Ehime University, Matsuyama 790-8566, Japan.
authors.forename: Ikue
authors.initials: I
authors.lastname: Sugimoto
authors.affiliation: Faculty of Agriculture, Department of Agrobiological Science, Ehime University, Matsuyama 790-8566, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Ogino
authors.affiliation: Faculty of Agriculture, Department of Agrobiological Science, Ehime University, Matsuyama 790-8566, Japan.
authors.forename: Md Sakirul Islam
authors.initials: MS
authors.lastname: Khan
authors.affiliation: Section of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Masuda
authors.affiliation: Section of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ukena
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002645:Chickens / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D006728:Hormones; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D003346:Corticotropin-Releasing Hormone; D013007:Growth Hormone-Releasing Hormone; D003345:Corticosterone
keywords: Chick; Corticotropin-releasing hormone; Feeding; Growth hormone-releasing hormone; Growth hormone-releasing hormone-like peptide; Intracerebroventricular injection; Pituitary adenylate cyclase-activating polypeptide