title: CLASP: a microtubule-based integrator of the  hormone-mediated transitions from cell  division to elongation.
abstract: Plants use robust mechanisms to optimize organ size to prevailing conditions. Modulating the transition from cell division to elongation dramatically affects morphology and size. Although it is well established that auxin, cytokinin and brassinosteroid mediate these transitions, recent works show that the cytoskeleton, which is normally thought to act downstream of these hormones, plays a key role in this regulatory process. In particular, the microtubule-associated protein CLASP has a dual role in meristem maintenance. CLASP modulates levels of the auxin efflux carrier PIN2 by tethering SNX1 endosomes to cortical microtubules, which in turn fine tunes auxin maxima in the root apical meristem. CLASP is also required for transfacial microtubule bundle formation at the sharp cell edges, a feature strongly associated with maintaining the capacity for further cell division.
authors.affiliation: The University of British Columbia, Department of Botany, 6270 University Blvd, Vancouver, BC V6T 1Z4, Canada.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: The University of British Columbia, Department of Botany, 6270 University Blvd, Vancouver, BC V6T 1Z4, Canada. Electronic address: geoffrey.wasteneys@ubc.ca.
authors.forename: Geoffrey O
authors.initials: GO
authors.lastname: Wasteneys
mesh_terms: D002455:Cell Division / Q000502:physiology; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D018519:Meristem / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D010940:Plant Proteins