title: Work of breathing in children with diffuse parenchymal lung disease.
abstract: Respiratory mechanics have been poorly studied in children with chronic diffuse parenchymal lung disease (DPLD). The aim of the study was to assess the usefulness of respiratory mechanics to monitor lung function alteration in children with DPLD. Respiratory mechanics, total (WOBt), elastic (WOBe) and resistive (WOBr) work of breathing, gas exchange, lung function and respiratory muscle strength were measured in 10 children, aged 1.8-18.4 years old, who were followed in our national reference centre. Mean tidal volume (Vt) was normal (11±4mL/kg) but respiratory rate (fr, 32±19breaths/min), fr/Vt (118±75breaths/min/L) and total lung resistance (10.2±4.8cmH2OL(-1)s) were increased. Mean WOBt was increased mainly due to WOBe. Dynamic lung compliance (Cldyn) was severely reduced (26±24mL/cmH2O). Cldyn and the oesophageal pressure-time product strongly correlated with vital capacity and functional residual capacity. Respiratory muscle strength was within the normal range. In conclusion, lung mechanics may be considered as useful complementary or alternative markers of functional abnormalities in children with DPLD.
authors.affiliation: ASV Santé, 125 avenue Roche, 92230 Gennevilliers, France; AP-HP, Hôpital Necker, Pediatric noninvasive ventilation and sleep unit, 149 rue de Sèvres, 75015 Paris, France. Electronic address: sonia_khirani@yahoo.fr.
authors.forename: Sonia
authors.initials: S
authors.lastname: Khirani
authors.affiliation: AP-HP, Hôpital Armand Trousseau, Pediatric Pulmonary Department, 26 avenue du Dr Netter, 75012 Paris, France. Electronic address: nadia.nathan@trs.aphp.fr.
authors.forename: Nadia
authors.initials: N
authors.lastname: Nathan
authors.affiliation: AP-HP, Hôpital Necker, Pediatric noninvasive ventilation and sleep unit, 149 rue de Sèvres, 75015 Paris, France; ADEP Assistance, 2 rue Benoit Malon, 92150 Suresnes, France. Electronic address: a.ramirez@adepassistance.fr.
authors.forename: Adriana
authors.initials: A
authors.lastname: Ramirez
authors.affiliation: AP-HP, Hôpital Necker, Pediatric noninvasive ventilation and sleep unit, 149 rue de Sèvres, 75015 Paris, France. Electronic address: aloui.sabrina1@gmail.com.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Aloui
authors.affiliation: AP-HP, Hôpital Necker, Pediatric Pulmonary Department, 149 rue de Sèvres, 75015 Paris, France. Electronic address: christophe.delacourt@nck.aphp.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Delacourt
authors.affiliation: AP-HP, Hôpital Armand Trousseau, Pediatric Pulmonary Department, 26 avenue du Dr Netter, 75012 Paris, France; INSERM UMR S-938, UMPC Paris 6 University, 27 rue Chaligny, 75012 Paris, France; UMPC Paris 6 University, 4 place Jussieu, 75005 Paris, France. Electronic address: annick.clement@trs.aphp.fr.
authors.forename: Annick
authors.initials: A
authors.lastname: Clément
authors.affiliation: AP-HP, Hôpital Necker, Pediatric noninvasive ventilation and sleep unit, 149 rue de Sèvres, 75015 Paris, France; INSERM U 955, Equipe 13, 8 rue du Général Sarrail, 94010 Créteil, France; Paris Descartes University, 12 rue Ecole de Médecine, 75006 Paris, France. Electronic address: brigitte.fauroux@nck.aphp.fr.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000473:pathology; D013223:Statistics as Topic; D013990:Tidal Volume; D014797:Vital Capacity
keywords: Breathing pattern; Child; Diffuse parenchymal lung disease; Interstitial lung disease; Lung compliance; Work of breathing