title: Anticoagulant proteins in a population of Mexican mestizo donors.
abstract: BACKGROUND
  To determine the activity of antithrombin (AT), protein C (PC), and protein S (PS), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican mestizo blood donors.
  
  
  METHODS
  AT, PC, and PS were determined from 1,502 plasma samples of healthy blood donors by using commercial kits in a coagulometer 4 STA (Diagnostica Stago, Asnières, France).
  
  
  RESULTS
  A total of 741 women and 761 men were under study. They were divided into age range groups (18-24, 25-34, 35-44, 45-54, and 55-64 years). Activity of AT, PC, and PS was determined. For AT, activity values were specific for each age group according to gender when it had to do with PS, as well as when PC was determined. Frequencies of AT, PC, PS, and activated PC resistance activity deficiencies were obtained from reference levels (RLs) and average levels of this study. Differences were found between both frequencies for AT, PC, and PS, and the average levels obtained were used in this study. The frequencies of the activity deficiencies obtained through the values gotten in this population were: AT, 0.6%; PC, 1.06% (which is higher than the one obtained using the RLs described by commercial kits 0.33% and 0.66%, respectively); and PS, 1% (which is less than 4.5%).
  
  
  CONCLUSIONS
  It is necessary to know the characteristics and biological behavior of the coagulation proteins in the Mexican population because the RLs used have been established for populations that are genetically different.
authors.affiliation: Hematology Department, Centro Médico Nacional Siglo XXI, Mexico City, Mexico.
authors.forename: Luis Antonio
authors.initials: LA
authors.lastname: Meillón-García
authors.affiliation: Genetic Department, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Hernández-Zamora
authors.affiliation: Hematology Department, Centro Médico Nacional Siglo XXI, Mexico City, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Montiel-Manzano
authors.affiliation: Pathology Central Laboratory, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
authors.forename: Cesar
authors.initials: C
authors.lastname: Zavala-Hernández
authors.affiliation: Physiology Department, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ramírez-San Juan
authors.affiliation: Hematology Department, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cesarman-Maus
authors.affiliation: Morphology Department, Cytology Laboratory, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address: elbareyesm@gmail.com.
authors.forename: Elba
authors.initials: E
authors.lastname: Reyes-Maldonado
mesh_terms: D000293:Adolescent; D000328:Adult; D020152:Antithrombin III Deficiency / Q000097:blood / Q000175:diagnosis / Q000208:ethnology; D058833:Antithrombin Proteins / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000208:ethnology*; D001779:Blood Coagulation Factors / Q000032:analysis*; D001780:Blood Coagulation Tests; D001782:Blood Donors; D005260:Female; D006801:Humans; D007198:Indians, North American; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011237:Predictive Value of Tests; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency / Q000097:blood / Q000175:diagnosis / Q000208:ethnology; D017293:Protein S / Q000032:analysis; D018455:Protein S Deficiency / Q000097:blood / Q000175:diagnosis / Q000208:ethnology; D055815:Young Adult
chemical_list: D058833:Antithrombin Proteins; D015415:Biomarkers; D001779:Blood Coagulation Factors; D011486:Protein C; D017293:Protein S