title: [18F]-FDG PET-CT prediction of response to induction chemotherapy in head and neck squamous cell carcinoma: preliminary findings.
abstract: OBJECTIVE
  The present study assessed the predictive value of [18F]-FDG PET-CT (positron emission tomography with 18-fluoro-eoxyglucose radiotracer, coupled to computerized tomography) for response to induction chemotherapy in head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  [18F]-FDG PET-CT was systematically performed before treatment initiation and after the first cycle of chemotherapy. Results were compared with those of endoscopy and pathologic analysis of biopsy and surgical specimens.
  
  
  RESULTS
  This preliminary study included 21 previously untreated HNSCC patients. A decrease of more than 30% in SUVmax (maximum standard uptake value) during induction was predictive of tumor response to chemotherapy (P=0.04). PET-CT measurement of hypermetabolic volume based on a predetermined SUV threshold (SUV=2.5), on the other hand, proved non-predictive.
  
  
  CONCLUSIONS
  These preliminary findings are promising. A larger sample, however, would be required in order to determine a more precise SUVmax reduction cut-off threshold during induction. Other methods for determining metabolic volume thresholds will be investigated. If functional imaging proves contributive, it could enable early screening of non-responders, avoiding unnecessary intoxication.
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France; Laboratoire d'anatomie, faculté de médecine, université Jean-Monnet, 42023 Saint-Étienne cedex 2, France. Electronic address: marie.gavid@chu-st-etienne.fr.
authors.forename: M
authors.initials: M
authors.lastname: Gavid
authors.affiliation: Service de médecine nucléaire, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
authors.forename: N
authors.initials: N
authors.lastname: Prevot-Bitot
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
authors.forename: A
authors.initials: A
authors.lastname: Timoschenko
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, Nancy, France.
authors.forename: P
authors.initials: P
authors.lastname: Gallet
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.affiliation: Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France; Laboratoire d'anatomie, faculté de médecine, université Jean-Monnet, 42023 Saint-Étienne cedex 2, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Prades
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D060828:Induction Chemotherapy; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18-fluorodeoxyglucose; Head and neck squamous cell carcinoma; PET-CT; TPF induction chemotherapy