title: miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine?
abstract: miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors.forename: Emeline
authors.initials: E
authors.lastname: Goretti
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg; Division of Cardiology, Centre Hospitalier, 4 rue Barblé, L-1210 Luxembourg, Luxembourg.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wagner
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. Electronic address: yvan.devaux@crp-sante.lu.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Devaux
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome; D014336:Troponin / Q000235:genetics / Q000378:metabolism
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs; D014336:Troponin
keywords: biomarker; miRNAs; myocardial infarction; personalized medicine; therapeutic targets