title: Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury.
abstract: OBJECTIVE
  Restenosis after vascular intervention remains a major clinical problem. Circulating LR11 has been shown a novel marker of intimal smooth muscle cell (SMC) proliferation in human and animal studies. The present study was performed to clarify the clinical significance of circulating LR11 in patients with stable angina pectoris after coronary stenting.
  
  
  RESULTS
  We firstly investigated the circulating sLR11 levels for 28 days after arterial injury in mice, and then assessed time-dependent change in circulating sLR11 level after coronary stenting in a clinical study. Mouse sLR11 levels rapidly increased to 4.0-fold of the control value without cuff placement at postoperative day (POD) 14, and the levels gradually declined to 3.1-fold of the control value until POD 28 in mice. The circulating soluble LR11 levels were measured (before and at 14, 60 and 240 days after coronary stenting in a clinical study of 102 consecutive patients with stable angina pectoris who were treated with percutaneous coronary intervention. Circulating sLR11 levels were significantly increased on days 14 and 60 after the procedure and positively associated with the angiographic late loss index.
  
  
  CONCLUSIONS
  Our study suggested that circulating sLR11 levels may be a potential marker for angiographic late loss in patients after coronary stenting. Further mechanistic studies are expected to know the clinical significance of sLR11 as a novel marker for intimal SMC.
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ogita
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan. Electronic address: ktmmy@med.juntendo.ac.jp.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Department of Clinical-laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Japan.
authors.forename: Meizi
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Kasai
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Shuta
authors.initials: S
authors.lastname: Tsuboi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Naito
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Konishi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Dohi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yokoyama
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Okazaki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Clinical-laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000473:pathology / Q000628:therapy; D000792:Angiography; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation; D023903:Coronary Restenosis; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000097:blood*; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood*; D051379:Mice; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000166:cytology*; D062645:Percutaneous Coronary Intervention; D011184:Postoperative Period; D011973:Receptors, LDL / Q000097:blood*; D015607:Stents; D057772:Vascular System Injuries / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; D011973:Receptors, LDL; C102582:SORL1 protein, human; C491168:Sorl1 protein, mouse
keywords: Biomarker; Percutaneous coronary intervention; Restenosis; Smooth muscle cell; Vascular injury