title: chinmo Mutant fly testis stem cells switching sex farewell to maleness.
abstract: Maintaining cellular identity is crucial for homeostasis, and sexual fates of vertebrate testis and ovary cells require continual reinforcement. In this issue of Developmental Cell, Ma et al. (2014) provide insights into stem cell fate maintenance in Drosophila, finding that the JAK/STAT target chinmo prevents transformation of testis somatic stem cells into their ovarian counterparts.
authors.affiliation: Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: zarko001@umn.edu.
authors.forename: David
authors.initials: D
authors.lastname: Zarkower
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D053612:Janus Kinases / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D019849:Sex Determination Processes / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*; D013737:Testis / Q000378:metabolism*
chemical_list: C515167:Chinmo protein, Drosophila; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D050791:STAT Transcription Factors; D053612:Janus Kinases