title: Anti-Candida and anti-Cryptococcus antifungal produced by marine microorganisms.
abstract: In order to search for antifungal from biological origin, we performed a screening of marine microorganisms isolated from seawater, seaweed, sediment and marine invertebrates collected from different coastal areas of the Moroccan Atlantic Ocean. The antifungal activities of these isolates were investigated against the pathogenic yeasts involved in medical mycology. Whole cultures of 34 marine microorganisms were screened for antifungal activities using the method of agar diffusion against four yeasts. The results showed that among the 34 isolates studied, 13 (38%) strains have antifungal activity against at least one out of four yeast species, 11 isolates have anti-Candida albicans CIP 48.72 activity, 12 isolates have anti-C. albicans CIP 884.65 activity, 13 isolates have anti-Cryptococcus neoformans activity and only 6 isolates are actives against Candida tropicalis R2 resistant to nystatin and amphotericin B. Nine isolates showed strong fungicidal activity. Fourteen microorganisms were identified and assigned to the genera Acinetobacter, Aeromonas, Alcaligenes, Bacillus, Chromobacterium, Enterococcus, Pantoea, and Pseudomonas. Due to a competitive role for space and nutrient, the marine microorganisms could produce more antimicrobials; therefore these marine microorganisms were expected to be potential resources of natural products such as those we research: anti-Candida and anti-Cryptococcus fungicides.
authors.affiliation: Laboratoire de contrôle qualité en bio-industrie et molécules bioactives, faculté des sciences, université Chouaib Doukkali, BP 20, 24000 El Jadida, Morocco; Faculté polidisciplinaire, université Ibn Zohr, BP 271, 83000 Taroudant, Morocco. Electronic address: elamraouibelkassem@yahoo.fr.
authors.forename: B
authors.initials: B
authors.lastname: El Amraoui
authors.affiliation: Laboratoire de contrôle qualité en bio-industrie et molécules bioactives, faculté des sciences, université Chouaib Doukkali, BP 20, 24000 El Jadida, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: El Amraoui
authors.affiliation: Institut pasteur, microbiologie des aliments et de l'environnement, Casablanca, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Cohen
authors.affiliation: Laboratoire de contrôle qualité en bio-industrie et molécules bioactives, faculté des sciences, université Chouaib Doukkali, BP 20, 24000 El Jadida, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: Fassouane
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry / Q000378:metabolism*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy; D003453:Cryptococcosis / Q000188:drug therapy; D003454:Cryptococcus / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents
keywords: Activité antifongique; Antifungal activity; Candida; Cryptococcus; Fongicide; Fungicide