title: Lipid rafts, KCa/ClCa/Ca2+ channel complexes and EGFR signaling: Novel targets to reduce tumor development by lipids?
abstract: Membrane lipid rafts are distinct plasma membrane nanodomains that are enriched with cholesterol, sphingolipids and gangliosides, with occasional presence of saturated fatty acids and phospholipids containing saturated acyl chains. It is well known that they organize receptors (such as Epithelial Growth Factor Receptor), ion channels and their downstream acting molecules to regulate intracellular signaling pathways. Among them are Ca2+ signaling pathways, which are modified in tumor cells and inhibited upon membrane raft disruption. In addition to protein components, lipids from rafts also contribute to the organization and function of Ca2+ signaling microdomains. This article aims to focus on the lipid raft KCa/ClCa/Ca2+ channel complexes that regulate Ca2+ and EGFR signaling in cancer cells, and discusses the potential modification of these complexes by lipids as a novel therapeutic approach in tumor development. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guéguinou
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Gambade
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Félix
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Chantôme
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Fourbon
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France; Centre HS Kaplan, CHRU Tours, Tours F-37032, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bougnoux
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Günther
authors.initials: G
authors.lastname: Weber
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Potier-Cartereau
authors.affiliation: Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours F-37032, France; Université François Rabelais, Tours F-37032, France. Electronic address: christophe.vandier@univ-tours.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Vandier
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D044243:Linoleic Acids, Conjugated / Q000627:therapeutic use; D008563:Membrane Lipids / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D021962:Membrane Microdomains / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D015220:Calcium Channels; D018118:Chloride Channels; D015525:Fatty Acids, Omega-3; D007527:Isoenzymes; D044243:Linoleic Acids, Conjugated; D008563:Membrane Lipids; D015221:Potassium Channels; C512478:EGFR protein, human; D066246:ErbB Receptors; D002118:Calcium
keywords: Calcium channel; Caveola; Chloride channel; EGFR; Lipid raft; Potassium channel