title: Factorial clinical trials: a new approach to phase II neuro-oncology studies.
authors.affiliation: Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center.
authors.forename: Fabio M
authors.initials: FM
authors.lastname: Iwamoto
authors.affiliation: Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Lassman
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D003606:Dacarbazine / Q000031:analogs & derivatives*; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D011720:Pyrazoles; D013449:Sulfonamides; D013792:Thalidomide; D003606:Dacarbazine; D015474:Isotretinoin