title: Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: A resting-state fMRI study.
abstract: OBJECTIVE
  We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain.
  
  
  METHODS
  With fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions.
  
  
  RESULTS
  IBS patients showed decreased ALFF values in the left superior frontal gyrus, right hippocampus, right middle frontal gyrus, bilateral postcentral, and right superior temporal pole, while increased ALFF values in the left median cingulate and left calcarine. There was significant correlation between ALFF values in the altered regions and duration of disease in IBS. FC analysis revealed the increased connectivity between cingulate and frontal cortex in IBS.
  
  
  CONCLUSIONS
  Our findings could provide both regional and brain connectivity spontaneous neuronal activity properties in IBS.
  
  
  CONCLUSIONS
  Our study may lead to a better understanding of intrinsic functional architecture of brain activity in IBS and highlight the potential for using the ALFF and FC metrics as a disease biomarker.
authors.affiliation: Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China.
authors.forename: Junzhang
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China. Electronic address: GH.jiang2002@163.com.
authors.forename: Guihua
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wen
authors.affiliation: Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China.
authors.forename: Tianyue
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Zhan
authors.affiliation: Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China. Electronic address: yikaivip@163.com.
authors.forename: Yikai
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D012146:Rest / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology; D055815:Young Adult
keywords: Amplitude of low-frequency fluctuate (ALFF); Functional connectivity (FC); Functional magnetic resonance imaging (fMRI); Irritable bowel syndrome (IBS); Spontaneous neuronal activity