title: Preparation of starch nanospheres through hydrophobic modification followed by initial water dialysis.
abstract: Starch nanospheres smaller than 200 nm were produced from hydrophobically modified starch by using initial water dialysis method. The hydrophobic modification of starch was performed by using octenyl succinic anhydride (OSA). The resultant starch nanospheres were characterized by using Fourier transformation infrared (FTIR) spectroscopy, (1)H nuclear magnetic resonance ((1)H NMR) spectroscopy and fluorescence spectroscopy, scanning electron microscopy (SEM) and dynamic light scattering (DLS). Effects of degree of substitution (DS) in OSA-starch, initial water content and OSA-starch concentration on morphology and particle size of starch nanospheres were evaluated. The SEM micrographs showed that starch nanospheres with spherical shape and sharp edge can be produced at DS values ≧0.67. The particle size of starch nanospheres decreased significantly (P<0.05) with increase in DS of OSA-starch and increase in the initial water content, whereas the particle size increased significantly (P<0.05) with the increase in the concentration of OSA-starch. These OSA-starch nanospheres can be preferentially used to microencapsulate hydrophobic drugs.
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, Guangdong 510640, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Non-Food Biomass and Enzyme Technology/National Engineering Research Center for Non-food Biorefinery/Guangxi Biomass Industrialization Engineering Institute/Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi 530007, China.
authors.forename: Bing-Zheng
authors.initials: BZ
authors.lastname: Li
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, Guangdong 510640, China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Xia
authors.affiliation: School of Applied Sciences, RMIT University, City Campus, Melbourne, VIC 3001, Australia.
authors.forename: Benu
authors.initials: B
authors.lastname: Adhikari
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, Guangdong 510640, China. Electronic address: qygao@scut.edu.cn.
authors.forename: Qunyu
authors.initials: Q
authors.lastname: Gao
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: C551966:octenyl succinic anhydride-modified starch; D014867:Water; D013213:Starch
keywords: Amphiphilic; Dialysis; Dimethyl sulfoxide (PubChem CID: 679); Dimethyl sulfoxide-d(6) (PubChem CID: 75151); Nanospheres; OSA-starch; Pyrene (PubChem CID: 31423); Pyridine (PubChem CID: 1049); Self-assemble; Trifluoroacetic acid (PubChem CID: 6422); n-Octenyl succinic anhydride (PubChem CID: 24442)