title: Pertussis may be the cause of prolonged cough in adolescents and adults in the interepidemic period.
abstract: OBJECTIVE
  This study was aimed to evaluate the prevalence of pertussis in adolescents and adults with cough lasting more than 14 days and less than 30 days.
  
  
  METHODS
  This is a prospective observational study in interepidemic period of pertusis. Ten public health outpatient clinics in the city of Recife, Brazil, were randomly selected for the study. The study population consisted of individuals aged 10 years and over with cough that had lasted between 14 and 30 days. Nasopharyngeal swabs were collected for culture and PCR in order to identify Bordetella pertussis. We adopted the Centers for Disease Control and Prevention in the US (CDC) definition of cases of pertussis.
  
  
  RESULTS
  A total of 192 individuals were identified as suspected cases. Their mean age was 40.7 years. Pertussis was confirmed in 10 of the 192 suspected cases, with an estimated prevalence of 5.21% (95% confidence interval 2.03-8.38). All cases met the clinical case definition for pertussis; one suspect had both culture and PCR positive. PCR confirmed 100% of the cases, 7/10 by PCR and 3/10 by epidemiological linkage with a case confirmed by PCR.
  
  
  CONCLUSIONS
  During an interepidemic period, 1 in 20 cases of prolonged cough had pertussis, suggesting this is an important cause of prolonged cough in adolescents and adults.
authors.affiliation: Pediatric Infectious Diseases Service, School Hospital, Universidade de Pernambuco, Recife, PE, Brazil. Electronic address: analiriapimentel@terra.com.br.
authors.forename: Analíria Moraes
authors.initials: AM
authors.lastname: Pimentel
authors.affiliation: Pediatric Infectious Diseases Service, School Hospital, Universidade de Pernambuco, Recife, PE, Brazil.
authors.forename: Paulo Neves
authors.initials: PN
authors.lastname: Baptista
authors.affiliation: Tropical Medicine Department, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors.forename: Ricardo Arraes de Alencar
authors.initials: RA
authors.lastname: Ximenes
authors.affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, London, UK.
authors.forename: Laura Cunha
authors.initials: LC
authors.lastname: Rodrigues
authors.affiliation: Tropical Medicine Department, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors.forename: Vera
authors.initials: V
authors.lastname: Magalhães
authors.forename: Andrea Rosane Sousa
authors.initials: AR
authors.lastname: Silva
authors.forename: Nadjla Ferreira
authors.initials: NF
authors.lastname: Souza
authors.forename: Deize Gomes Cavalcanti de
authors.initials: DG
authors.lastname: Matos
authors.forename: Ana Kelly Lins
authors.initials: AK
authors.lastname: Pessoa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000235:genetics / Q000276:immunology; D001938:Brazil; D002648:Child; D004269:DNA, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D014917:Whooping Cough / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial
keywords: Adolescents and adults; Pertussis (whooping cough); Prevalence; Prolonged cough