title: Effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis.
abstract: OBJECTIVE
  To observe the effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis.
  
  
  METHODS
  Bilateral femoral head necrosis models of rabbit were established by steroid injection. A total of 48 rabbits (96 femoral head necrosis) were randomly divided into 4 groups: Group A, control group with12 rabbits, 24 femoral head necrosis; Group B, treated with rhBMP-2/PLGA implantation after core depression, with 12 rabbits, 24 femoral head necrosis; Group C, treated with rhBMP-2 implantation after core depression, with 12 rabbits, 24 femoral head necrosis; Group D treated with core depression group without implantation, with 12 rabbits, 24 femoral head necrosis. All animals were sacrificed after 12 weeks. The ability of repairing bone defect was evaluated by X-ray radiograph. Bone mineral density analysis of the defect regions were used to evaluate the level of ossification. The morphologic change and bone formation was assessed by HE staining. The angiogenesis was evaluated by VEGF immunohistochemistry.
  
  
  RESULTS
  The osteogenetic ability and quality of femoral head necrosis in group B were better than those of other groups after 12 weeks by X-ray radiograph and morphologic investigation. And the angiogenesis in group B was better than other groups. Group C had similar osteogenetic quality of femoral head necrosis and angiogenesis with group D.
  
  
  CONCLUSIONS
  The treatment of rhBMP-2/PLGA implantation after core depression can promote the repair of rabbit femoral head necrosis. It is a promising and efficient synthetic bone material to treat the femoral head necrosis.
authors.affiliation: Department of Joint Surgery, No 89 Hospital of People's Liberation Army, Weifang 261021, China. Electronic address: guke89@126.com.
authors.forename: Zhao-Xun
authors.initials: ZX
authors.lastname: Pan
authors.affiliation: Department of Joint Surgery, No 89 Hospital of People's Liberation Army, Weifang 261021, China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Department of Joint Surgery, No 89 Hospital of People's Liberation Army, Weifang 261021, China.
authors.forename: Ye-Xin
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Joint Surgery, No 89 Hospital of People's Liberation Army, Weifang 261021, China.
authors.forename: Long-Di
authors.initials: LD
authors.lastname: Zhai
authors.affiliation: Department of Joint Surgery, No 89 Hospital of People's Liberation Army, Weifang 261021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
keywords: Core decompression; Femoral head necrosis; Microsphere; rhBMP-2