title: Flagellar ion channels of sperm: similarities and differences between species.
abstract: Motility and fertilization potential of mammalian sperm are regulated by ion homeostasis which in turn is under tight control of ion channels and transporters. Sperm intracellular pH, membrane voltage and calcium concentration ([Ca(2+)]i) are all important for sperm activity within the female reproductive tract. While all mammalian sperm are united in their goal to find and fertilize an egg, the molecular mechanisms they utilize for this purpose are diverse and differ between species especially on the level of ion channels. Recent direct recording from sperm cells of different species indicate the differences between rodent, non-human primate, ruminant, and human sperm on the basic levels of their ion channel regulation. In this review we summarize the current knowledge about ion channel diversity of the animal kingdom and concentrate our attention on flagellar ion channels of mammalian sperm.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States; Department of Physiology, University of California, San Francisco, CA 94158, United States.
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Miller
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Mansell
authors.affiliation: Department of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Meyers
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States. Electronic address: lishko@berkeley.edu.
authors.forename: Polina V
authors.initials: PV
authors.lastname: Lishko
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D015221:Potassium Channels / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D013082:Sperm Tail / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; C510235:HVCN1 protein, human; D007473:Ion Channels; D015221:Potassium Channels; D017923:Sodium-Hydrogen Exchangers; D002118:Calcium
keywords: Capacitation; CatSper; Fertilization; Flagellar calcium channel; Hv1; Hyperactivation; KSper; Non-genomic progesterone signaling; Slo1; Slo3; Sperm ion channels