title: Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease.
abstract: It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.
authors.affiliation: Veterans Affairs, Northern California Health Care System, Sacramento, CA, USA.
authors.forename: Alicia D
authors.initials: AD
authors.lastname: Rueda
authors.affiliation: Department of Neurology, University of California, Davis, Sacramento, CA.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Lau
authors.affiliation: Department of Public Health Sciences, University of California, Davis, Davis, CA, USA.
authors.forename: Naomi
authors.initials: N
authors.lastname: Saito
authors.affiliation: Department of Public Health Sciences, University of California, Davis, Davis, CA, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Harvey
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Risacher
authors.affiliation: Department of Neuroscience, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
authors.affiliation: Department of Neurology and the Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
authors.affiliation: Department of Neurology, University of California, Davis, Sacramento, CA. Electronic address: sarah.farias@ucdmc.ucdavis.edu.
authors.forename: Sarah Tomaszewski
authors.initials: ST
authors.lastname: Farias
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000523:psychology*; D000814:Aniline Compounds; D053327:Apolipoprotein E4 / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000523:psychology*; D005026:Ethylene Glycols; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D057566:Self Report; D012720:Severity of Illness Index
chemical_list: D000814:Aniline Compounds; D053327:Apolipoprotein E4; D015415:Biomarkers; D005026:Ethylene Glycols; D019275:Radiopharmaceuticals; C545186:florbetapir
keywords: ADNI; Alzheimer's disease; Biomarkers; Daily functioning; Dementia; Everyday function; Informant-report; Instrumental activities of daily living; Mild cognitive impairment (MCI); Self-report