title: [Selective biopsy of the sentinel lymph node in patients with breast cancer and previous excisional biopsy: is there a change in the reliability of the technique according to time from surgery?].
abstract: OBJECTIVE
  To assess the influence of time on the reliability of sentinel lymph node biopsy (SLNB) in breast cancer patients with previous excisional biopsy (EB), analyzing both the sentinel lymph node detection and the lymph node recurrence rate.
  
  
  METHODS
  Thirty-six patients with cT1/T2 N0 breast cancer and previous EB of the lesion underwent a lymphoscintigraphy after subdermal periareolar administration of radiocolloid, the day before SLNB. Patients were classified into two groups, one including 12 patients with up to 29 days elapsed between EB and SLNB (group A), and another with the remaining 24 in which time between both procedures was of 30 days or more (group B). Scintigraphic and surgical detection of the sentinel lymph node, histological status of the sentinel lymph node and of the axillary lymph node dissection, if performed, and lymphatic recurrences during follow-up, were analyzed.
  
  
  RESULTS
  Sentinel lymph node visualization at the lymphoscintigraphy and surgical detection were 100% in both groups. Histologically, three patients showed macrometastasis in the sentinel lymph node, one from group A and two from group B. None of the patients, not even those with malignancy of the sentinel lymph node, relapsed after a medium follow-up of 49.5 months (24-75).
  
  
  CONCLUSIONS
  Time elapsed between EB and SLNB does not influence the reliability of this latter technique as long as a superficial injection of the radiopharmaceutical is performed, proving a very high detection rate of the sentinel lymph node without evidence of lymphatic relapse during follow-up.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España. Electronic address: asabatell@bellvitgehospital.cat.
authors.forename: A
authors.initials: A
authors.lastname: Sabaté-Llobera
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España.
authors.forename: P C
authors.initials: PC
authors.lastname: Notta
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España; Unidad Funcional de Mama, Hospital Universitari de Bellvitge - IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: Benítez-Segura
authors.affiliation: Servicio de Cirugía Plástica, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España; Unidad Funcional de Mama, Hospital Universitari de Bellvitge - IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: López-Ojeda
authors.affiliation: Servicio de Oncología Médica, Institut Català d'Oncologia - Hospital Duran i Reynals, Barcelona, España; Unidad Funcional de Mama, Hospital Universitari de Bellvitge - IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: S
authors.initials: S
authors.lastname: Pernas-Simon
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España.
authors.forename: M P
authors.initials: MP
authors.lastname: Boya-Román
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, España; Unidad Funcional de Mama, Hospital Universitari de Bellvitge - IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: M T
authors.initials: MT
authors.lastname: Bajén
mesh_terms: D000368:Aged; D001365:Axilla; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D061305:Lymphoscintigraphy; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012008:Recurrence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D000071036:Sentinel Lymph Node / Q000000981:diagnostic imaging / Q000473:pathology*; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C083602:technetium Tc 99m nanocolloid
keywords: Biopsia escisional; Biopsia selectiva del ganglio centinela; Breast cancer; Cáncer de mama; Excisional biopsy; Sentinel lymph node biopsy