title: [Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort].
abstract: OBJECTIVE
  To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients.
  
  
  METHODS
  Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset<16 years (JOSpA group) and age at onset ≥ 16 years (AOSpA group).
  
  
  RESULTS
  Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p<0.001), lower limb arthritis (p=0.001), enthesitis (p=0.008), anterior uveitis (p=0.041) and positive HLA-B27 (p=0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI; p=0.007) and functionality (Bath Ankylosing Spondylitis Functional Index - BASFI; p=0.036). Cutaneous psoriasis (p<0.001), inflammatory bowel disease (p=0.023), dactylitis (p=0.024) and nail involvement (p=0.004) were more frequent in patients with adult-onset SpA.
  
  
  CONCLUSIONS
  Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.
authors.affiliation: Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Angela P
authors.initials: AP
authors.lastname: Duarte
authors.affiliation: Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Cláudia D L
authors.initials: CD
authors.lastname: Marques
authors.affiliation: Insper Instituto de Educação e Pesquisa, São Paulo, SP, Brasil.
authors.forename: Adriana B
authors.initials: AB
authors.lastname: Bortoluzzo
authors.affiliation: Divisão de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Célio R
authors.initials: CR
authors.lastname: Gonçalves
authors.affiliation: Universidade de Brasília, Brasília, DF, Brasil.
authors.forename: José Antonio Braga
authors.initials: JA
authors.lastname: da Silva
authors.affiliation: Hospital Geral de Goiânia, Goiânia, GO, Brasil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Ximenes
authors.affiliation: Universidade de Campinas, Campinas, SP, Brasil.
authors.forename: Manoel B
authors.initials: MB
authors.lastname: Bértolo
authors.affiliation: Universidade Federal do Amazonas, Manaus, AM, Brasil.
authors.forename: Sandra Lúcia E
authors.initials: SL
authors.lastname: Ribeiro
authors.affiliation: Pontifícia Universidade Católica, Porto Alegre, RS, Brasil.
authors.forename: Mauro
authors.initials: M
authors.lastname: Keiserman
authors.affiliation: Hospital Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Sueli
authors.initials: S
authors.lastname: Carneiro
authors.affiliation: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brasil.
authors.forename: Rita
authors.initials: R
authors.lastname: Menin
authors.affiliation: Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: Valderilio F
authors.initials: VF
authors.lastname: Azevedo
authors.affiliation: Hospital Geral de Fortaleza, Fortaleza, CE, Brasil.
authors.forename: Walber P
authors.initials: WP
authors.lastname: Vieira
authors.affiliation: Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Elisa N
authors.initials: EN
authors.lastname: Albuquerque
authors.affiliation: Santa Casa do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Washington A
authors.initials: WA
authors.lastname: Bianchi
authors.affiliation: Pontifícia Universidade Católica, Campinas, SP, Brasil.
authors.forename: Rubens
authors.initials: R
authors.lastname: Bonfiglioli
authors.affiliation: Santa Casa de São Paulo, São Paulo, SP, Brasil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Campanholo
authors.affiliation: Hospital de Base do Distrito Federal, Brasília, DF, Brasil.
authors.forename: Hellen M S
authors.initials: HM
authors.lastname: Carvalho
authors.affiliation: Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors.forename: Izaias P
authors.initials: IP
authors.lastname: Costa
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Kohem
authors.affiliation: Faculdade de Medicina Souza Marques, Rio de Janeiro, RJ, Brasil.
authors.forename: Nocy
authors.initials: N
authors.lastname: Leite
authors.affiliation: Hospital do Servidor Público Estadual, São Paulo, SP, Brasil.
authors.forename: Sonia A L
authors.initials: SA
authors.lastname: Lima
authors.affiliation: Instituto de Ortopedia e Traumatologia, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Eduardo S
authors.initials: ES
authors.lastname: Meirelles
authors.affiliation: Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors.forename: Ivânio A
authors.initials: IA
authors.lastname: Pereira
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Pinheiro
authors.affiliation: Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.
authors.forename: Elizandra
authors.initials: E
authors.lastname: Polito
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Gustavo G
authors.initials: GG
authors.lastname: Resende
authors.affiliation: Universidade Federal do Ceará, Fortaleza, CE, Brasil.
authors.forename: Francisco Airton C
authors.initials: FA
authors.lastname: Rocha
authors.affiliation: Escola de Medicina e Saúde Pública, Salvador, BA, Brasil.
authors.forename: Mittermayer B
authors.initials: MB
authors.lastname: Santiago
authors.affiliation: Universidade Federal do Pará, Belém, PA, Brasil.
authors.forename: Maria de Fátima L C
authors.initials: Mde F
authors.lastname: Sauma
authors.affiliation: Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
authors.forename: Valéria
authors.initials: V
authors.lastname: Valim
authors.forename: Percival D
authors.initials: PD
authors.lastname: Sampaio-Barros
authors.affiliation: Divisão de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil. Electronic address: pdsampaiobarros@uol.com.br.
authors.forename: Percival D Sampaio
authors.initials: PD
authors.lastname: Barros
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D025241:Spondylarthritis / Q000175:diagnosis* / Q000453:epidemiology*; D013167:Spondylitis, Ankylosing; D055815:Young Adult
keywords: Artrite crônica na infância; Artrite relacionada à entesite; Brazilian population; Chronic arthritis in childhood; Enthesitis‐related arthritis; Epidemiologia; Epidemiology; Espondiloartrite de início juvenil; Juvenile‐onset spondyloarthritis; População brasileira