title: Portulaca oleracea reduces triglyceridemia, cholesterolemia, and improves lecithin: cholesterol acyltransferase activity in rats fed enriched-cholesterol diet.
abstract: OBJECTIVE
  The effects of Portulaca oleracea (Po) lyophilized aqueous extract were determined on the serum high-density lipoproteins (HDL2 and HDL3) amounts and composition, as well as on lecithin: cholesterol acyltansferase (LCAT) activity.
  
  
  METHODS
  Male Wistar rats (n = 12) were fed on 1% cholesterol-enriched diet for 10 days. After this phase, hypercholesterolemic rats (HC) were divided into two groups fed the same diet supplemented or not with Portulaca oleracea (Po-HC) (0.5%) for four weeks.
  
  
  RESULTS
  Serum total cholesterol (TC) and triacylglycerols (TG), and liver TG values were respectively 1.6-, 1.8-, and 1.6-fold lower in Po-HC than in HC group. Cholesterol concentrations in LDL-HDL1, HDL2, and HDL3 were respectively 1.8, 1.4-, and 2.4-fold decreased in Po-HC group. HDL2 and HDL3 amounts, which were the sum of apolipoproteins (apos), TG, cholesteryl esters (CE), unesterified cholesterol (UC), and phospholipids (PL) contents, were respectively 4.5-fold higher and 1.2-fold lower with Po treatment. Indeed, enhanced LCAT activity (1.2-fold), its cofactor-activator apo A-I (2-fold) and its reaction product HDL2-CE (2.1-fold) were observed, whereas HDL3-PL (enzyme substrate) and HDL3-UC (acyl group acceptor) were 1.2- and 2.4-fold lower.
  
  
  CONCLUSIONS
  Portulaca oleracea reduces triglyceridemia, cholesterolemia, and improves reverse cholesterol transport in rat fed enriched-cholesterol diet, contributing to anti-atherogenic effects.
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, BP 1534 El M'Naouer, 31000 Oran, Algeria.
authors.forename: Y
authors.initials: Y
authors.lastname: Zidan
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, BP 1534 El M'Naouer, 31000 Oran, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Bouderbala
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, BP 1534 El M'Naouer, 31000 Oran, Algeria.
authors.forename: F
authors.initials: F
authors.lastname: Djellouli
authors.affiliation: Laboratoire de Pharmacognosie, EA 4267, FDE/UFC, Faculté de Pharmacie, Université de Bourgogne, 21079 Dijon, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Lacaille-Dubois
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, BP 1534 El M'Naouer, 31000 Oran, Algeria. Electronic address: bouchenak.malika@lncm-univoran.com.
authors.forename: M
authors.initials: M
authors.lastname: Bouchenak
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D006937:Hypercholesterolemia / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D031822:Portulaca / Q000737:chemistry*; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
keywords: HDL(2); HDL(3); Hypercholesterolemic rat; LCAT; Portulaca oleracea