title: Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus.
abstract: OBJECTIVE
  Due to the chronic inflammation associated with systemic lupus erythematosus (SLE), patients develop premature atherosclerosis and the disease is a risk factor for acute myocardial infarction. The best interventional treatment for acute coronary syndrome (ACS) in these patients is unclear. The objective of this study is to describe the baseline characteristics, clinical manifestations, treatment and in-hospital outcome of patients with SLE and ACS.
  
  
  METHODS
  Eleven SLE patients with ACS were analyzed retrospectively between 2004 and 2011. The following data were obtained: age, gender, clinical and electrocardiographic characteristics, Killip class, risk factors for ACS, myocardial necrosis markers (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), drugs used during hospital stay, treatment (medical, percutaneous or surgical) and in-hospital outcome. The statistical analysis is presented in percentages and absolute values.
  
  
  RESULTS
  Ten of the patients (91%) were women. The median age was 47 years. Typical precordial pain was present in 91%. Around 73% had positive erythrocyte sedimentation rate. The vessel most often affected was the anterior descending artery, in 73%. One patient underwent coronary artery bypass grafting, seven underwent percutaneous coronary intervention with bare-metal stents and three were treated medically. In-hospital mortality was 18%.
  
  
  CONCLUSIONS
  Despite the small number of patients, our findings were similar to those in the literature, showing coronary artery disease in young people with SLE due to premature atherosclerosis and a high mortality rate.
authors.affiliation: Unidade Clínica de Emergência do Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. Electronic address: alexandre.soeiro@bol.com.br.
authors.forename: Alexandre
authors.initials: A
authors.lastname: de Matos Soeiro
authors.affiliation: Unidade Clínica de Emergência do Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Maria Carolina Feres
authors.initials: MC
authors.lastname: de Almeida Soeiro
authors.affiliation: Unidade Clínica de Emergência do Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Mucio Tavares
authors.initials: MT
authors.lastname: de Oliveira
authors.affiliation: Unidade Clínica de Emergência do Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Carlos Viente
authors.initials: CV
authors.lastname: Serrano
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D000328:Adult; D005260:Female; D006760:Hospitalization; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Acute coronary syndromes; Inflamação; Inflammation; Lúpus eritematoso sistêmico; Systemic lupus erythematosus; Síndrome coronária aguda