title: Neuromuscular ultrasound findings in polyneuropathy secondary to disulfiram.
abstract: Disulfiram toxicity can cause multiple neurologic problems, including a reversible distal sensorimotor axonal polyneuropathy. Although electrodiagnosis and biopsy results have been described in the diagnosis and management of patients with disulfiram associated polyneuropathy, neuromuscular ultrasound findings have not been reported. The authors present a case of electrodiagnostically confirmed axonal polyneuropathy with relative sural sparing secondary to disulfiram and describe the neuromuscular ultrasound findings in this individual. Ultrasound demonstrated distal enlargement with slight side-to-side asymmetry and normal proximal cross-sectional area in the lower extremity nerves. Neuromuscular ultrasound is another diagnostic modality that may be used to assist in the diagnosis of patients with polyneuropathy secondary to disulfiram.
authors.affiliation: Departments of *Neurology and †Family Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, U.S.A.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Stone
authors.forename: Michael S
authors.initials: MS
authors.lastname: Cartwright
authors.forename: Oana R
authors.initials: OR
authors.lastname: Panea
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Vann
authors.forename: John L
authors.initials: JL
authors.lastname: Magruder
authors.forename: Francis O
authors.initials: FO
authors.lastname: Walker
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D000437:Alcoholism / Q000188:drug therapy*; D004221:Disulfiram / Q000009:adverse effects*; D006801:Humans; D035002:Lower Extremity / Q000294:innervation*; D008297:Male; D009460:Neurologic Examination; D020258:Neurotoxicity Syndromes / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D017933:Peripheral Nervous System / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D011115:Polyneuropathies / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D020127:Recovery of Function; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram