title: [SD-OCT As screening test for hydroxychloroquine retinopathy: The «flying saucer» sign].
abstract: METHODS
  Two asymptomatic women treated with hydroxychloroquine 200mg every day for 8 and 16 years developed retinal toxicity.
  
  
  CONCLUSIONS
  Patient 1 was found to have a normal fundus and autofluorescence examination. Patient 2 was found to have a completely normal fundus examination. Fluorescein angiography shows parafoveal hyperfluorescence, and autofluorescence shows a minimal decrease in signal in the same region. In both patients the SD-OCT shows disruption of the ellipsoid zone in parafoveal region («flying saucer» sign). SD-OCT findings in the retina can identify hydroxychloroquine retinopathy in asymptomatic patients.
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario, Valladolid, España. Electronic address: victor_asensio@orangemail.es.
authors.forename: V M
authors.initials: VM
authors.lastname: Asensio-Sánchez
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000000981:diagnostic imaging*; D005654:Fundus Oculi; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D012164:Retinal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine
keywords: Hidroxichloroquina; Hydroxychloroquine; Maculopathy; Maculopatía; Prueba de detección; SD-OCT; Screening test; Signo «del platillo volante»; «Flying saucer» sign