title: Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients.
abstract: OBJECTIVE
  Several markers were found to be potential prognostic factors in ovarian cancer. Among markers resembling systemic changes in the host's organism are markers of the oxidative stress. In this study we attempted to analyze the oxidant and antioxidant parameters of ovarian cancer patients.
  
  
  METHODS
  A total of 42 patients with newly diagnosed stages I-IV primary ovary cancer were examined. Level of malondialdehyde (MDA) and catalytic activity catalase (CAT) were determined spectrophotometrically.
  
  
  RESULTS
  Significantly lower CAT (28.2±15.5 vs. 36.1±14.6nmol/L/min, P=0.019) activity and higher MDA levels (8.7±3.0 vs. 6.7±2.7nmol/L, P=0.002) were observed in cancer patients compared with healthy volunteers. Both variables were not confirmed as prognostic factors according to Kaplan-Meier survival estimates.
  
  
  CONCLUSIONS
  MDA and CAT demonstrate oxidative stress in cancer patients: CAT activity was significantly lower and MDA levels higher in cancer patients compared to healthy controls. These variables were not confirmed to be prognostic factors in ovarian cancer, possibly due to small size of the study group.
authors.affiliation: Scientific Research Centre, National Cancer Institute, Vilnius, Lithuania; Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
authors.forename: Janina
authors.initials: J
authors.lastname: Didžiapetrienė
authors.affiliation: Scientific Research Centre, National Cancer Institute, Vilnius, Lithuania; Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Bublevič
authors.affiliation: Scientific Research Centre, National Cancer Institute, Vilnius, Lithuania.
authors.forename: Giedrė
authors.initials: G
authors.lastname: Smailytė
authors.affiliation: Scientific Research Centre, National Cancer Institute, Vilnius, Lithuania. Electronic address: Birute.Kazbariene@nvi.lt.
authors.forename: Birutė
authors.initials: B
authors.lastname: Kazbarienė
authors.affiliation: Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
authors.forename: Rimantas
authors.initials: R
authors.lastname: Stukas
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002374:Catalase / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D008315:Malondialdehyde; D002374:Catalase
keywords: Catalase; Malondialdehyde; Ovarian cancer; Oxidative stress; Survival