title: Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress.
abstract: Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme.
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Hegedűs
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary; MTA-DE Cell Biology and Signaling Research Group, Debrecen, Hungary. Electronic address: lvirag@med.unideb.hu.
authors.forename: László
authors.initials: L
authors.lastname: Virág
mesh_terms: D000818:Animals; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D000071137:Poly (ADP-Ribose) Polymerase-1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000074747:Poly ADP Ribosylation / Q000187:drug effects / Q000502:physiology*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*
chemical_list: D011064:Poly Adenosine Diphosphate Ribose; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1
keywords: Apoptosis; Cell death; Necroptosis; Oxidative stress; PARP1; Poly(ADP-ribosyl)ation