title: Adherence to fesoterodine in women with overactive bladder in routine clinical practice.
abstract: OBJECTIVE
  To assess the short-term compliance with fesoterodine treatment and to identify the reasons for lack of adherence and discontinuation in routine clinical practice. The secondary aim was to estimate the patient-reported outcomes.
  
  
  METHODS
  This was an observational retrospective, multicenter study conducted in a sample of women with overactive bladder on fesoterodine treatment for at least three months. Adherence to medication was assessed using the Morisky-Green test. Patient-reported outcomes were assessed using the Incontinence Questionnaire Short Form (ICIQ-SF), Overactive Bladder Questionnaire Short Form (OAB-qSF), and Treatment Benefit Scale (TBS).
  
  
  RESULTS
  One hundred and twenty women with a mean age [standard deviation (SD)] of 62.2 (12.0) years with severe OAB [mean (SD) ICIQ-SF score 13.2 (4.0)] were included. 42.1% of the patients were considered compliant with fesoterodine treatment. The main causes for non-compliance/discontinuation stated by the remaining 57.9% of the patients were adverse events (62.2%) and lack of clinical benefits (20.0%). The illness status as well as the patient-perceived bother occasioned by the OAB symptoms and their impact on the quality of life improved significantly after three months on fesoterodine treatment (p<0.0001). Most of the patients stated that the current state of their urinary problems had greatly improved/ improved.
  
  
  CONCLUSIONS
  In routine clinical practice, a high percentage of patients were adherent to fesoterodine and perceived the benefit that the treatment provided them three months after starting treatment. However, more than half of the study population failed to comply or discontinued the treatment mainly due to intolerance or lack of efficacy.
authors.affiliation: Departamento de Obstetricia y Ginecología, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: msimo@santpau.cat.
authors.forename: M
authors.initials: M
authors.lastname: Simó
authors.affiliation: Departamento de Obstetricia y Ginecología, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: O
authors.initials: O
authors.lastname: Porta
authors.affiliation: Departamento de Obstetricia y Ginecología, Corporació Sanitària Parc Taulí, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Pubill
authors.affiliation: Departamento de Obstetricia y Ginecología, Parc de Salut Mar, Barcelona, España.
authors.forename: M T
authors.initials: MT
authors.lastname: Castillo
authors.affiliation: Departamento de Obstetricia y Ginecología, Hospital d'Igualada, Barcelona, España.
authors.forename: I
authors.initials: I
authors.lastname: Mora
authors.affiliation: Departamento de Obstetricia y Ginecología, Hospital Viladecans, Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Huguet
authors.affiliation: PASSIR Dreta, Institut Català de la Salut, Barcelona, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Ortega
authors.affiliation: Departamento de Obstetricia y Ginecología, Parc Sanitari Sant Joan de Déu Sant Boi, Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Martínez
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D055118:Medication Adherence; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D017060:Patient Satisfaction; D011788:Quality of Life; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000523:psychology
chemical_list: D001559:Benzhydryl Compounds; D018727:Muscarinic Antagonists; C526675:fesoterodine
keywords: Adherence; Adherencia; Fesoterodina; Fesoterodine; Overactive bladder; Vejiga hiperactiva