title: Neuromuscular and neuropsychological assessments in survivors of acute respiratory distress syndrome: exploratory comparisons with an at-risk cohort.
abstract: BACKGROUND
  Long-term studies of survivors of acute respiratory distress syndrome (ARDS) have reported neuromuscular, quality of life, and neuropsychological impairments. This study aims to determine if development of ARDS was associated with neuromuscular weakness and depression at 6-month following hospital discharge in a population-based cohort of patients at high risk for ARDS.
  
  
  METHODS
  A validated lung injury prediction model prospectively identified adult patients at increased risk for ARDS admitted to Mayo Clinic between October 2008 and July 2011. Instruments for functional impairment [Overall Neuropathy Limitations Scale (ONLS)] and the presence of depressive symptoms (the Yale Single Question) were administered at baseline and at 6 months.
  
  
  RESULTS
  Of 107 patients enrolled in the study, 98 (92 %) underwent baseline assessment. Of these, 83 (85 %) were admitted to intensive care, 41 (42 %) developed ARDS, and 67 (68 %) completed assessment at 6 months. Patients with ARDS had longer intensive care and hospital length of stay (7.9 vs. 3.1 days, p = 0.005 and 19.5 vs. 10.6 days, p = 0.004, respectively). There was no difference in reported functional impairment at 6 months from baseline in the ARDS group compared to the non-ARDS group-mean ONLS Total Score 2.95 versus 2.07 p = 0.09 and 3.0 versus 2.1 p = 027, respectively. There was also no difference in the prevalence of depression at 6 months between the ARDS and non-ARDS group (21.9 vs. 30.7 % p = 0.41).
  
  
  CONCLUSIONS
  In this single-center population-based cohort study, survivors of ARDS in the community had similar reported functional impairment and depression prevalence compared to an at-risk cohort that did not develop ARDS.
authors.affiliation: Division of Critical Care Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA, uofoma@geisinger.edu.
authors.forename: Uchenna R
authors.initials: UR
authors.lastname: Ofoma
authors.forename: Martin K
authors.initials: MK
authors.lastname: Reriani
authors.forename: Michelle
authors.initials: M
authors.lastname: Biehl
authors.forename: Rahul
authors.initials: R
authors.lastname: Kashyap
authors.forename: Adil H
authors.initials: AH
authors.lastname: Ahmed
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000453:epidemiology*; D009483:Neuropsychological Tests; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D018570:Risk Assessment