title: [Purulent pericarditis and colonic infiltrating to Salmonella enteritidis complicated by acute intussusception in a case of IL-12Rβ1 deficiency].
abstract: IL-12 receptor β1 deficiency (IL-12Rβ1) predisposes patients to mycobacteria and Salmonella infections. We report a case of IL-12Rβ1 deficiency with a fatal multi-resistant Salmonella enteritidis infection. This boy was born after from a consanguineous marriage, and diagnosed as having a IL-12Rβ1 deficiency since the age of 3 months. He presented with recurrent Salmonella enteritidis essentially digestive localization, complicated by purulent pericarditis at the same germ at the age of two and a half years. At the age of 3, a colonic infiltration due to a Salmonella enteritidis resistant to antibiotics, was complicated by acute intussusception, and the child died. The IL-12Rβ1 deficiency is considered as having a good prognosis, in contrast to what happened in our patient. We review therapeutic issues in these patients.
authors.affiliation: Unité d'immunologie clinique, service de pédiatrie 1, hôpital d'Enfants Abderrahim Harouchi, CHU Ibn Rochd, Casablanca, Maroc. Electronic address: ailalfatima@yahoo.fr.
authors.forename: F
authors.initials: F
authors.lastname: Ailal
authors.affiliation: Unité d'immunologie clinique, service de pédiatrie 1, hôpital d'Enfants Abderrahim Harouchi, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Tazi
authors.affiliation: Laboratoire de génétique humaine des maladies infectieuses, institut national de la santé et de la recherche médicale, U980, 75015 Paris, France; Faculté de médecine de Necker, université Paris René-Descartes-Cité Sorbonne, 75015 Paris, France; Centre d'études des déficits immunitaires (CEDI), hôpital Necker-Enfants-Malades, 75015 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Bustamante
authors.affiliation: Laboratoire de génétique humaine des maladies infectieuses, institut national de la santé et de la recherche médicale, U980, 75015 Paris, France; Faculté de médecine de Necker, université Paris René-Descartes-Cité Sorbonne, 75015 Paris, France; Centre d'études des déficits immunitaires (CEDI), hôpital Necker-Enfants-Malades, 75015 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Picard
authors.affiliation: Unité d'immunologie clinique, service de pédiatrie 1, hôpital d'Enfants Abderrahim Harouchi, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: J
authors.initials: J
authors.lastname: Najib
authors.affiliation: Laboratoire de génétique humaine des maladies infectieuses, institut national de la santé et de la recherche médicale, U980, 75015 Paris, France; Faculté de médecine de Necker, université Paris René-Descartes-Cité Sorbonne, 75015 Paris, France; Saint-Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller, University, New York, États-Unis.
authors.forename: J-L
authors.initials: JL
authors.lastname: Casanova
authors.affiliation: Unité d'immunologie clinique, service de pédiatrie 1, hôpital d'Enfants Abderrahim Harouchi, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: A A
authors.initials: AA
authors.lastname: Bousfiha
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003108:Colonic Diseases / Q000382:microbiology*; D006801:Humans; D007443:Intussusception / Q000382:microbiology*; D008297:Male; D010493:Pericarditis / Q000382:microbiology*; D012480:Salmonella Infections / Q000150:complications*; D012477:Salmonella enteritidis; D013492:Suppuration / Q000382:microbiology