title: Abdominal aortic diameter is increased in males with a family history of abdominal aortic aneurysms: results from the Danish VIVA-trial.
abstract: OBJECTIVE
  To investigate, at a population level, whether a family history of abdominal aortic aneurysm (AAA) is independently related to increased aortic diameter and prevalence of AAA in men, and to elucidate whether the mean aortic diameter and the prevalence of AAA are different between participants with male and female relatives with AAA.
  
  
  METHODS
  Observational population-based cross-sectional study.
  
  
  METHODS
  18,614 male participants screened for AAA in the VIVA-trial 2008-2011 with information on both family history of AAA and maximal aortic diameter.
  
  
  METHODS
  Standardized ultrasound scan measurement of maximum antero-posterior aortic diameter. Family history obtained by questionnaire. Multivariate regression analysis was used to test for confounders: age, sex, smoking, comorbidity and medication.
  
  
  RESULTS
  From the screened cohort, 569 participants had at least one first degree relative diagnosed with AAA, and 38 had AAA. Participants with a family history of AAA (+FH) had a significantly larger mean maximum aortic diameter (20.50 mm) compared with participants without family history of AAA (-FH) (19.07 mm, p < .0001), and +FH with female relatives with AAA had significantly larger mean maximum aortic diameter (21.8 mm) than +FH with male relatives (19.9 mm, p = .007). Furthermore the prevalence of AAA was significantly higher among +FH (6.7%) compared with -FH (3.0%) with an odds ratio (OR) of 2.2 (95% CI: 1.6 to 3.2, p < .001) and +FH with female relatives with AAA had a more than two and a half times increased prevalence of AAA compared with +FH with male relatives with AAA with an OR of 2.65.
  
  
  CONCLUSIONS
  First-degree male relatives of AAA patients have wider aortas and a twofold higher prevalence of AAA compared with the age adjusted background population. The prevalence of AAA was markedly higher in participants related to female, rather than male, patients with AAA.
authors.affiliation: Department of Vascular Surgery, Kolding Hospital and University of Southern Denmark, Denmark. Electronic address: Trine.Maria.Mejnert.Joergensen@rsyd.dk.
authors.forename: T M M
authors.initials: TM
authors.lastname: Joergensen
authors.affiliation: Department of Vascular Surgery, Kolding Hospital and University of Southern Denmark, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Houlind
authors.affiliation: Odense Patient Data Exploratory Network, Odense University Hospital and University of Southern Denmark, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Denmark.
authors.forename: J S
authors.initials: JS
authors.lastname: Lindholt
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000235:genetics*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D004108:Dilatation, Pathologic; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010375:Pedigree; D010641:Phenotype; D011237:Predictive Value of Tests; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D014463:Ultrasonography
keywords: Abdominal aneurysm; Family history; Vascular surgery