title: Scientific contributions toward successful cancer immunotherapy in The Netherlands.
abstract: This historical overview shows that immunologists and clinicians from The Netherlands have contributed in a major way to better insights in the nature of cancer immunity. This work involved elucidation of the nature of cancer-associated antigens in autologous and allogeneic settings in addition to understanding of the cellular basis of natural immune responses against cancers and of important immune evasion mechanisms. Insight into such basic immunological mechanisms has contributed to the development of innovating therapies.
authors.affiliation: Leiden University Medical Center, The Netherlands; ISA Pharmaceuticals, The Netherlands. Electronic address: c.melief@lumc.nl.
authors.forename: Cornelis J M
authors.initials: CJ
authors.lastname: Melief
authors.affiliation: Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: Rik J
authors.initials: RJ
authors.lastname: Scheper
authors.affiliation: Department of Tumor Immunology, Radboud UMC, Nijmegen, The Netherlands.
authors.forename: I Jolanda M
authors.initials: IJ
authors.lastname: de Vries
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000266:history* / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D009426:Netherlands; D019139:Tumor Escape
chemical_list: D000951:Antigens, Neoplasm
keywords: Cancer Immunology; Cancer immunotherapy; Cancer vaccine; Combination treatment; History of immunology; Monoclonal antibody