title: Novel azoles as potent and selective cannabinoid CB2 receptor agonists.
abstract: Novel azole compounds were prepared which demonstrated potent hCB2 binding activities with antioxidant activity for a selected compound. These compounds show good selectivity over the hCB1 receptor and are full agonists at the hCB2 receptor.
authors.affiliation: Ipsen Innovation, Department of Compound Discovery, 5 Avenue du Canada, 91940 Les Ulis, France. jeremiah.harnett@ipsen.com
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Harnett
authors.forename: Christine
authors.initials: C
authors.lastname: Dolo
authors.forename: Isabelle
authors.initials: I
authors.lastname: Viossat
authors.forename: Florence
authors.initials: F
authors.lastname: Auger
authors.forename: Eric
authors.initials: E
authors.lastname: Ferrandis
authors.forename: Dennis
authors.initials: D
authors.lastname: Bigg
authors.forename: Michel
authors.initials: M
authors.lastname: Auguet
authors.forename: Serge
authors.initials: S
authors.lastname: Auvin
authors.forename: Pierre-E
authors.initials: PE
authors.lastname: Chabrier
mesh_terms: D000818:Animals; D001393:Azoles / Q000737:chemistry* / Q000378:metabolism*; D016466:CHO Cells; D063386:Cannabinoid Receptor Agonists / Q000737:chemistry* / Q000378:metabolism*; D002186:Cannabinoids / Q000737:chemistry / Q000378:metabolism; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000378:metabolism*
chemical_list: D001393:Azoles; D063386:Cannabinoid Receptor Agonists; D002186:Cannabinoids; D043885:Receptor, Cannabinoid, CB2