title: Effect of tiletamine-zolazepam on the intraocular pressure of the dog.
abstract: OBJECTIVE
  To determine the effect of tiletamine-zolazepam (TZ) on canine intraocular pressure (IOP).
  
  
  METHODS
  Six healthy dogs without ocular abnormalities were used in this study.
  
  
  METHODS
  The study was carried out as a crossover experimental trial with a 7-day interval between treatments. TZ combination was administered intravenously (IV) at a dose of 5, 10, and 20 mg/kg (TZ5, TZ10, and TZ20, respectively). Following preanesthetic baseline readings of IOP, each dog received IV TZ and then the IOP values were measured every 10 min for 40 min in all treatments.
  
  
  RESULTS
  The baseline IOP values (mean ± standard deviation) for TZ5, TZ10, and TZ20 were 12.7 ± 0.8, 14.4 ± 1.2, and 15.3 ± 1.7 mmHg, and each IOP changed to 11.1 ± 1.1, 13.1 ± 1.4 and 13.5 ± 1.7 mmHg after intravenous administration of each TZ treatment, respectively. However, there were no statistical differences between baseline and post-treatment values.
  
  
  CONCLUSIONS
  The TZ combination had no clinically significant effect on IOP of the dog. This could be an option for induction or surgical procedures in dogs with ophthalmic problems when an increase in IOP is undesirable.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Jang
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Sangwan
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Won-Gyun
authors.initials: WG
authors.lastname: Son
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Jo
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Hyeshin
authors.initials: H
authors.lastname: Hwang
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Kangmoon
authors.initials: K
authors.lastname: Seo
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Inhyung
authors.initials: I
authors.lastname: Lee
mesh_terms: D000818:Animals; D018592:Cross-Over Studies; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007275:Injections, Intravenous / Q000662:veterinary; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D013992:Tiletamine / Q000008:administration & dosage* / Q000627:therapeutic use; D014065:Tonometry, Ocular / Q000662:veterinary; D015041:Zolazepam / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D013992:Tiletamine; D015041:Zolazepam
keywords: dog; intraocular pressure; tiletamine; zolazepam