title: Pharmacogenetic study of second-generation antipsychotic long-term treatment metabolic side effects (the SLiM Study): rationale, objectives, design and sample description.
abstract: OBJECTIVE
  Weight gain is an important and common side effect of second generation antipsychotics (SGAs). Furthermore, these drugs can induce other side effects associated with higher cardiovascular morbidity and mortality, such as insulin resistance, diabetes or metabolic syndrome. Preliminary studies show that inter-individual genetic differences produce varying degrees of vulnerability to the different SGA-induced side effects. The Second-generation antipsychotic Long-term treatment Metabolic side effects (SLiM) study aims to identify clinical, environmental and genetic factors that explain inter-individual differences in weight gain and metabolic changes in drug-naïve patients after six months of treatment with SGAs.
  
  
  METHODS
  The SLIM study is a multicenter, observational, six-month pharmacogenetic study where a cohort of 307 drug-naïve paediatric and adult patients (age range 8.8-90.1 years) and a cohort of 150 age- and sex- matched healthy controls (7.8-73.2 years) were recruited.
  
  
  RESULTS
  This paper describes the rationale, objectives and design of the study and provides a description of the sample at baseline.
  
  
  CONCLUSIONS
  Results from the SLiM study will provide a better understanding of the clinical, environmental, and genetic factors involved in weight gain and metabolic disturbances associated with SGA treatment.
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, Londres, Reino Unido. Electronic address: lpina.iisgm@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Pina-Camacho
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España.
authors.forename: Covadonga M
authors.initials: CM
authors.lastname: Díaz-Caneja
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, España.
authors.forename: Pilar A
authors.initials: PA
authors.lastname: Saiz
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, España.
authors.forename: Julio
authors.initials: J
authors.lastname: Bobes
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, España.
authors.forename: Iluminada
authors.initials: I
authors.lastname: Corripio
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, España.
authors.forename: Eva
authors.initials: E
authors.lastname: Grasa
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría, Instituto de Investigación Hospital 12 de octubre (i+12), Universidad Complutense, Madrid, España.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodriguez-Jimenez
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría, Hospital Universitario de Santiago Apóstol, Universidad del País Vasco, Vitoria, España.
authors.forename: Miryam
authors.initials: M
authors.lastname: Fernández
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Departamento de Psiquiatría, Hospital Clínico INCLIVA, Universidad de Valencia, Valencia, España.
authors.forename: Julio
authors.initials: J
authors.lastname: Sanjuán
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Aurelio
authors.initials: A
authors.lastname: García-López
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Tapia-Casellas
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España.
authors.forename: María
authors.initials: M
authors.lastname: Álvarez-Blázquez
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España.
authors.forename: David
authors.initials: D
authors.lastname: Fraguas
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Unitat d́Antropologia, Departament de Biologia Animal, Facultat de Biologia e Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, España.
authors.forename: Marina
authors.initials: M
authors.lastname: Mitjans
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Unitat d́Antropologia, Departament de Biologia Animal, Facultat de Biologia e Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, España.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Arias
authors.affiliation: CIBER del área de Salud Mental (CIBERSAM), España; Servicio de Psiquiatría del Niño y del Adolescente, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, IiSGM, Madrid, España.
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000235:genetics*; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012107:Research Design; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: Agentes antipsicóticos; Antipsychotic Agents; Aumento de peso; Drug-Related Side Effects and Adverse Reactions; Efectos secundarios y reacciones adversas a medicamentos; Farmacogenética; Metabolic Syndrome; Pharmacogenetics; Síndrome metabólico; Weight Gain