title: Electrochemical advanced oxidation for cold incineration of the pharmaceutical ranitidine: mineralization pathway and toxicity evolution.
abstract: Ranitidine (RNTD) is a widely prescribed histamine H2-receptor antagonist whose unambiguous presence in water sources appointed it as an emerging pollutant. Here, the degradation of 0.1 mM of this drug in aqueous medium was studied by electrochemical advanced oxidation processes (EAOPs) like anodic oxidation with electrogenerated H2O2 and electro-Fenton using Pt/carbon-felt, BDD/carbon-felt and DSA-Ti/RuO2–IrO2/carbon-felt cells. The higher oxidation power of the electro-Fenton process using a BDD anode was demonstrated. The oxidative degradation of RNTD by the electrochemically generated OH radicals obeyed a pseudo-first order kinetics. The absolute rate constant for its hydroxylation reaction was 3.39 × 109 M−1 s−1 as determined by the competition kinetics method. Almost complete mineralization of the RNTN solution was reached by using a BDD anode in both anodic oxidation with electrogenerated H2O2 and electro-Fenton processes. Up to 11 cyclic intermediates with furan moiety were detected from the degradation of RNTD, which were afterwards oxidized to short-chain carboxylic acids before their mineralization to CO2 and inorganic ions such as NH4+, NO3− and SO42−. Based on identified products, a plausible reaction pathway was proposed for RNTD mineralization. Toxicity assessment by the Microtox® method revealed that some cyclic intermediates are more toxic than the parent molecule. Toxicity was quickly removed following the almost total mineralization of the treated solution. Overall results confirm the effectiveness of EAOPs for the efficient removal of RNTD and its oxidation by-products from water.
authors.affiliation: Université Paris-Est, Laboratoire Géomatériaux et Environnement (LGE), EA 4508, UPE, 77454 Marne-la-Vallée, France.
authors.forename: Hugo
authors.initials: H
authors.lastname: Olvera-Vargas
authors.forename: Nihal
authors.initials: N
authors.lastname: Oturan
authors.forename: Enric
authors.initials: E
authors.lastname: Brillas
authors.forename: Didier
authors.initials: D
authors.lastname: Buisson
authors.forename: Giovanni
authors.initials: G
authors.lastname: Esposito
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Oturan
mesh_terms: D048908:Aliivibrio fischeri / Q000187:drug effects*; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003080:Cold Temperature; D004566:Electrodes; D006635:Histamine H2 Antagonists / Q000737:chemistry / Q000633:toxicity; D008163:Luminescent Measurements; D010084:Oxidation-Reduction; D011899:Ranitidine / Q000737:chemistry* / Q000633:toxicity*; D021241:Spectrometry, Mass, Electrospray Ionization; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D014874:Water Pollutants, Chemical; D011899:Ranitidine