title: Inherited neurologic disorders in the dog: the science behind the solutions.
abstract: Canine inherited neurologic diseases are clinically varied and can be congenital, neonatal, or late onset as well as progressive or stationary. Modern genetic technologies are revolutionizing the speed and efficiency with which mutations responsible for inherited neurologic disease are being identified. Clinically similar disorders can be caused by different mutations, even within a single breed, and are thus genetically distinct. DNA tests can be used by dog breeders to reduce the prevalence of inherited neurologic disorders in specific breeds and help the veterinarian diagnose disease.
authors.affiliation: Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK. Electronic address: cathryn.mellersh@aht.org.uk.
authors.forename: Cathryn
authors.initials: C
authors.lastname: Mellersh
mesh_terms: D000818:Animals; D001947:Breeding; D002493:Central Nervous System Diseases / Q000235:genetics / Q000662:veterinary*; D004247:DNA / Q000235:genetics; D016208:Databases, Factual; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D008040:Genetic Linkage; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D009154:Mutation
chemical_list: D005819:Genetic Markers; D004247:DNA
keywords: DNA testing; Genetic mutation; Inherited disorder