title: Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus.
abstract: The aim of the present study was to assess the relationship between serum concentrations of several persistent organic pollutants and insulin resistance markers in a cohort of women with a history of gestational diabetes mellitus. ∑POPs was computed as the sum of individual serum POP concentrations. No statistically significant associations were found between levels of any POP and fasting glucose. However, polychlorinated biphenyl (PCB) congeners 138 and 180 were positively associated with 2-h glucose levels and PCB 180 also with fasting immunoreactive insulin (IRI). We also found a positive association of p,p'- dichlorodiphenyldichloroethylene (p,p'- DDE), PCBs (138, 153, and 180), hexachlorobenzene, and ∑POPs with 2-h IRI. Serum concentrations of PCBs (138, 153, and 180), hexachlorobenzene, and ∑POPs were also positively associated with homeostasis model assessment (HOMA2-IR) levels. Moreover, p,p'- DDE, PCBs (138, 153 and 180), hexachlorobenzene, and ∑POPs were negatively associated with Insulin Sensitivity Index (ISI-gly) levels. No significant association was found between glycated hemoglobin and the concentrations of any POP. The removal of women under blood glucose lowering treatment from the models strengthened most of the associations previously found for the whole population. Our findings suggest that exposure to certain POPs is a modifiable risk factor contributing to insulin resistance.
authors.affiliation: Radiation Oncology Department, Virgen de las Nieves University Hospital, Spain; Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Endocrine and Nutrition Unit, San Cecilio University Hospital, Spain.
authors.forename: Amalia
authors.initials: A
authors.lastname: González-Jiménez
authors.affiliation: Endocrine and Nutrition Unit, San Cecilio University Hospital, Spain.
authors.forename: Constanza
authors.initials: C
authors.lastname: Fornieles-González
authors.affiliation: Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Artacho-Cordón
authors.affiliation: Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Olea
authors.affiliation: Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; Endocrine and Nutrition Unit, San Cecilio University Hospital, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Escobar-Jiménez
authors.affiliation: Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; Endocrine and Nutrition Unit, San Cecilio University Hospital, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Fernández-Soto
mesh_terms: D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000097:blood*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009930:Organic Chemicals / Q000097:blood*; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D009930:Organic Chemicals
keywords: Homeostasis model assessment; Insulin Sensitivity Index; Insulin resistance; Organochlorine pesticides; Persistent organic pollutants; Polychlorinated biphenyls