title: Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate molecule for therapeutic intervention and prognostic biomarker?
abstract: While persistent infection with oncogenic types of human Papillomavirus (HPV) is required for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is not sufficient to induce tumorigenesis. Only a minor fraction of HPV infections produce high-grade lesions and cervical cancer, suggesting complex host-virus interactions. Based on its pronounced immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as a possible prognostic biomarker and therapeutic target relevant in a wide variety of cancers and viral infections, but to date remains underexplored in cervical cancer. Given the possible influence of HLA-G on the clinical course of HPV infection, cervical lesions and cancer progression, a better understanding of HLA-G involvement in cervical carcinogenesis might contribute to two aspects of fundamental importance: 1. Characterization of a novel diagnostic/prognostic biomarker to identify cervical cancer and to monitor disease stage, critical for patient screening; 2. Identification of HLA-G-driven immune mechanisms involved in lesion development and cancer progression, leading to the development of strategies for modulating HLA-G expression for treatment purposes. Thus, this systematic review explores the potential involvement of HLA-G protein expression and polymorphisms in cervical carcinogenesis.
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Gimenes
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Jorge Juarez Vieira
authors.initials: JJ
authors.lastname: Teixeira
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: André Luelsdorf Pimenta
authors.initials: AL
authors.lastname: de Abreu
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Raquel Pantarotto
authors.initials: RP
authors.lastname: Souza
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Monalisa Wolski
authors.initials: MW
authors.lastname: Pereira
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Vânia Ramos Sela
authors.initials: VR
authors.lastname: da Silva
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Cinthia Gandolfi
authors.initials: CG
authors.lastname: Bôer
authors.affiliation: Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of São Paulo, 05508000 São Paulo, Brazil.
authors.forename: Silvya Stuchi
authors.initials: SS
authors.lastname: Maria-Engler
authors.affiliation: College of Medicine, Departments of Medicine, Pharmacology and Pathology, University of Illinois at Chicago, 60612 Chicago, IL, USA.
authors.forename: Marcelo Gialluisi
authors.initials: MG
authors.lastname: Bonini
authors.affiliation: Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, 87020900 Paraná, Brazil.
authors.forename: Sueli Donizete
authors.initials: SD
authors.lastname: Borelli
authors.affiliation: Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020900 Paraná, Brazil. Electronic address: melconsolaro@gmail.com.
authors.forename: Márcia Edilaine Lopes
authors.initials: ME
authors.lastname: Consolaro
mesh_terms: D005260:Female; D059951:HLA-G Antigens / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011110:Polymorphism, Genetic; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000276:immunology* / Q000628:therapy
chemical_list: D059951:HLA-G Antigens
keywords: Cancer immunoediting; Cervical cancer; HLA-G; HPV; Prognostic biomarker; Therapeutic intervention