title: Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis.
abstract: Tick-borne encephalitis (TBE) has a wide clinical spectrum, from asymptomatic to severe encephalitis, and host-dependent factors determining the outcome remain elusive. We have measured concentrations of pro-inflammatory/Th1 interferon-γ (IFNγ), immunomodulatory/Th2 interleukin-10 (IL-10), anti-viral type I (IFNβ) and type III (IFNλ3) interferons in cerebrospinal fluid (csf) and serum of 18 TBE patients, simultaneously genotyped for polymorphisms associated with the expression of genes IFNL3 (coding IFNλ3), IL10, CD209 and CCR5. IL-10, IFNβ and IFNλ3 were up-regulated in csf, with IFNλ3 level higher in patients with the milder clinical presentation (meningitis) than in meningoencephalitis. There was an increased serum IFNβ and a tendency for increased serum IL-10 in meningitis patients. Genotype in rs12979860 locus upstream of IFNL3 was associated with IFNλ3 expression and in rs287886 (CD209) - IL-10 expression. IL-10, IFNβ and IFNλ3 are expressed and play a protective role in TBE and their expression in TBE patients is associated with genetic polymorphisms.
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland. Electronic address: grygorczuk.sambor@neostrada.pl.
authors.forename: Sambor
authors.initials: S
authors.lastname: Grygorczuk
authors.affiliation: Pomeranian Medical University, Department of the Infectious Diseases and Hepatology, ul. Arkońska 4, 71-455 Szczecin, Poland.
authors.forename: Miłosz
authors.initials: M
authors.lastname: Parczewski
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Moniuszko
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Świerzbińska
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zajkowska
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Czupryna
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Dunaj
authors.affiliation: Pomeranian Medical University, Department of the Infectious Diseases and Hepatology, ul. Arkońska 4, 71-455 Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Boroń-Kaczmarska
authors.affiliation: Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Pancewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000134:cerebrospinal fluid* / Q000235:genetics; D004679:Encephalomyelitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016899:Interferon-beta / Q000097:blood / Q000134:cerebrospinal fluid* / Q000235:genetics; D007372:Interferons; D016753:Interleukin-10 / Q000097:blood / Q000134:cerebrospinal fluid* / Q000235:genetics; D007378:Interleukins / Q000097:blood / Q000134:cerebrospinal fluid* / Q000235:genetics; D008297:Male; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics; D008590:Meningoencephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D016899:Interferon-beta; D007372:Interferons; D016753:Interleukin-10; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: IFNβ; IFNλ3; IL-10; Tick-borne encephalitis