title: Influence of GNB3 C825T polymorphism on the efficacy of antidepressants in the treatment of major depressive disorder: A meta-analysis.
abstract: OBJECTIVE
  We performed the present meta-analysis in order to evaluate the influence of a common polymorphism (C825T, rs5443 C>T) in the GNB3 gene on the efficacy of antidepressants in the treatment of major depressive disorder (MDD).
  
  
  METHODS
  A relevant literature was searched using the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CBM and CNKI databases without any language restrictions. STATA Version 12.0 software (Stata Corporation, College Station, Texas USA) was used for this meta-analysis. Odds ratio (OR) and its corresponding 95% confidence interval (95% CI) were calculated.
  
  
  RESULTS
  Our findings suggested that the GNB3 C825T polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients under the allele and dominant models. Furthermore, we found significant associations between GNB3 C825T polymorphisms and antidepressant-induced remission in MDD patients. Ethnicity-stratified analysis indicated that GNB3 C825T polymorphisms may be strongly related to the efficacy of antidepressants in the treatment of MDD among Asians, but not in Caucasians (all P>0.05).
  
  
  CONCLUSIONS
  Our findings provide empirical evidence that GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients.
authors.affiliation: Department of Psychology, Qiqihar Mental Health Center, Linhua Road No. 6, Jianhua District, Qiqihar 161000, China. Electronic address: huqiang0704@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Institute of Forensic Science, Ministry of Justice, P.R. China, Guangfu Road No. 1347, Shanghai 200030, China. Electronic address: tmac1zsy@163.com.
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Tongji Hospital, Tongji University, Shanghai 200065, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Pathology, Qiqihar Medical University, Qiqihar 161000, China.
authors.forename: Xiao Jie
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Mental Health Institute, Qiqihar Medical University, Qiqihar 161000, China.
authors.forename: Guang-Cheng
authors.initials: GC
authors.lastname: Cui
authors.affiliation: Research Center, Qiqihar Mental Health Center, Qiqihar 161000, China.
authors.forename: En-Qing
authors.initials: EQ
authors.lastname: Yu
authors.affiliation: Research Center, Qiqihar Mental Health Center, Qiqihar 161000, China.
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Xu
authors.affiliation: Mental Health Institute, Qiqihar Medical University, Qiqihar 161000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The First Hospital of Qiqihar City, Qiqihar 161000, China.
authors.forename: Jian-Qi
authors.initials: JQ
authors.lastname: Xiao
authors.affiliation: Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar 161000, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wei
authors.affiliation: Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Yin-Yin
authors.initials: YY
authors.lastname: Zang
mesh_terms: D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics*; D003596:Cytosine; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013941:Thymine
chemical_list: D000928:Antidepressive Agents; C000595803:GNB3 protein, human; D003596:Cytosine; D020962:Heterotrimeric GTP-Binding Proteins; D013941:Thymine
keywords: Efficacy; GNB3; Major depressive disorder; Meta-analysis; Polymorphism