title: Musculoskeletal, Neurologic, and Cardiopulmonary Aspects of Physical Rehabilitation in Patients with Chronic Graft-versus-Host Disease.
abstract: Chronic graft-versus-host disease (cGVHD) has the potential to cause significant morbidity and mortality in people who undergo allogeneic hematopoietic stem cell transplantation. Management of complications due to cGVHD can be challenging because of multiorgan involvement and variable presentation of the disease. This paper outlines the diagnosis and management of musculoskeletal, neurologic, and cardiopulmonary manifestations of cGVHD that have the potential to cause profound functional impairment and that may significantly impact quality of life and lifespan. Expert evaluation by a physical medicine and rehabilitation physician and multidisciplinary team may be beneficial in the treatment of the disease sequelae, and examples of specific rehabilitation interventions are described.
authors.affiliation: Cancer Rehabilitation, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan. Electronic address: srsz@med.umich.edu.
authors.forename: Sean Robinson
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Haig
authors.affiliation: Adult Blood and Marrow Transplantation Program, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Couriel
mesh_terms: D064591:Allografts; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D006331:Heart Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D009422:Nervous System Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation
keywords: Bone marrow transplantation rehabilitation; Cancer rehabilitation; Chronic graft-versus-host disease; Graft-versus-host disease; Physiatry; Rehabilitation of chronic graft-versus-host disease