title: Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation.
abstract: Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral response during the initial separation and separation the following day. Here we used the cyclooxygenase inhibitor naproxen to examine the role of prostaglandins in mediating the depressive-like behavior and core body temperature of young guinea pigs during an initial separation, separation the next day, and separation 10 days after the first. The passive, depressive-like behavior as well as fever sensitized with repeated separation. Three days of injection with 14 mg/kg of naproxen prior to the initial separation reduced depressive-like behavior during all three separations. A 28 mg/kg dose of naproxen, however, had minimal effect on behavior. Fever during the early separations was moderated by naproxen, but only at the higher dose. These results suggest a role of prostaglandins in the behavioral and febrile response to maternal separation, and particularly in the sensitization of depressive-like behavior following repeated separation.
authors.affiliation: Department of Psychology, Wright State University, Dayton, OH 45435, USA. Electronic address: michael.hennessy@wright.edu.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Hennessy
authors.affiliation: Department of Psychology, Wright State University, Dayton, OH 45435, USA.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Stafford
authors.affiliation: Department of Psychology, Wright State University, Dayton, OH 45435, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Yusko-Osborne
authors.affiliation: Department of Psychology, Wright State University, Dayton, OH 45435, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schiml
authors.affiliation: Department of Psychology, Wright State University, Dayton, OH 45435, USA.
authors.forename: Evan D
authors.initials: ED
authors.lastname: Xanthos
authors.affiliation: Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902, USA.
authors.forename: Terrence
authors.initials: T
authors.lastname: Deak
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008426:Maternal Deprivation; D009043:Motor Activity / Q000187:drug effects; D009288:Naproxen / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013686:Telemetry; D013997:Time Factors; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen
keywords: Depression; Early stress; Fever; Inflammatory; Maternal separation; Prostaglandins