title: Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy.
abstract: Type 2 immune responses in the skin cause a variety of pathologies, including urticaria and atopic dermatitis. Traditionally, CD4(+) helper T cells have been implicated in the pathogenesis of these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell, has emerged as an important contributor to skin allergies. In this review, we summarize our current knowledge of the role ILC2 cells play in the physiology and pathology of mouse and human skin.
authors.affiliation: The Centenary Institute, Newtown, NSW 2042, Australia; Discipline of Dermatology, Sydney Medical School, University of Sydney, NSW 2006, Australia. Electronic address: b.roediger@centenary.org.au.
authors.forename: Ben
authors.initials: B
authors.lastname: Roediger
authors.affiliation: Malaghan Institute of Medical Research, Wellington, New Zealand.
authors.forename: Ryan
authors.initials: R
authors.lastname: Kyle
authors.affiliation: Malaghan Institute of Medical Research, Wellington, New Zealand; Victoria University of Wellington, Wellington, New Zealand.
authors.forename: Graham
authors.initials: G
authors.lastname: Le Gros
authors.affiliation: The Centenary Institute, Newtown, NSW 2042, Australia; Discipline of Dermatology, Sydney Medical School, University of Sydney, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. Electronic address: w.weninger@centenary.org.au.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weninger
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D051379:Mice; D012867:Skin / Q000276:immunology* / Q000473:pathology; D014581:Urticaria / Q000276:immunology* / Q000473:pathology