title: The mitochondrial Ca(2+) uniporter complex.
abstract: Calcium influx into the mitochondrial matrix plays important roles in the regulation of cell death pathways, bioenergetics and cytoplasmic Ca(2+) signals. During the last few years, several molecular components of the inner membrane mitochondrial Ca(2+) uniporter, the dominant pathway for Ca(2+) influx into the mitochondrial matrix, have been identified. The uniporter is now recognized as a complex of proteins that include a Ca(2+) pore forming component and accessory proteins that are either required for its channel activity or regulate it under various conditions. This review summarizes recent discoveries about the molecular basis of the uniporter complex. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease."
authors.affiliation: Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA. Electronic address: foskett@mail.med.upenn.edu.
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Foskett
authors.affiliation: Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Philipson
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D033681:Mitochondrial Membrane Transport Proteins; C034703:mitochondrial calcium uniporter; D002118:Calcium
keywords: Bioenergetics; Calcium; Cardiomyocyte; EMRE; Heart; Ion channel; MCU; MCUR1; MICU1; MICU2; Mitochondria; Protein complex; Transport; Uniporter