title: Formation of hydrophilic nanofibers from nanoemulsions through electrospinning.
abstract: This study presents a method for one step incorporation of lipophilic compounds in hydrophilic nanofibers. By this method nanodroplets of oil and of volatile solvent are entrapped within polymer nanofibers during an electrospinning process. While performing the process with a volatile oil with dissolved lipophilic material, such as the drug celecoxib, nanofiber-nanoparticle composites are formed. The polymer used to form the fibers is a high molecular weight poly(vinyl alcohol) which enables rapid dissolution and release of the incorporated lipophilic material. The resulting celecoxib nanoparticles that are embedded within the nanofiber are amorphous and their average size is in between 21 and 93 nm, thus potentially lead to their increased dissolution rate. The preparation of such a solid matrix containing nanodroplets or nanoparticles may be applied as a fast dissolving delivery system for water insoluble materials.
authors.affiliation: Casali Center for Applied Chemistry, The Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: viktoriy.gordon@mail.huji.ac.il.
authors.forename: V
authors.initials: V
authors.lastname: Gordon
authors.affiliation: Casali Center for Applied Chemistry, The Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: gad.marom@mail.huji.ac.il.
authors.forename: G
authors.initials: G
authors.lastname: Marom
authors.affiliation: Casali Center for Applied Chemistry, The Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: magdassi@mail.huji.ac.il.
authors.forename: S
authors.initials: S
authors.lastname: Magdassi
mesh_terms: D000085:Acetates / Q000737:chemistry; D000068579:Celecoxib / Q000737:chemistry*; D004655:Emulsions; D006601:Hexoses / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000085:Acetates; D004655:Emulsions; D006601:Hexoses; D011136:Polysorbates; D012997:Solvents; D013501:Surface-Active Agents; C018665:sorbitan monooleate; C006848:butyl acetate; D011142:Polyvinyl Alcohol; D000068579:Celecoxib
keywords: Electrospinning; Emulsion; Fast dissolving delivery system; Lipophilic nanoparticles; Nanofibers