title: Translating human genetics into novel treatment targets for schizophrenia.
abstract: Human genetics is a rational starting point for target identification in drug discovery, yet this approach has found little application in neuroscience. Recent large-scale analyses have begun to identify robust genetic loci for schizophrenia, providing an opportunity to derive novel drug targets. Here, we summarize a strategy for applying human genetics to neuroscience drug discovery.
authors.affiliation: PharmaTherapeutics Clinical Research, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Schubert
authors.affiliation: Computational Sciences Center of Emphasis, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
authors.forename: Hualin S
authors.initials: HS
authors.lastname: Xi
authors.affiliation: PharmaTherapeutics Clinical Research, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address: jens.wendland@pfizer.com.
authors.forename: Jens R
authors.initials: JR
authors.lastname: Wendland
authors.affiliation: Neuroscience Research Unit, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address: patricio.odonnell@pfizer.com.
authors.forename: Patricio
authors.initials: P
authors.lastname: O'Donnell
mesh_terms: D000818:Animals; D055808:Drug Discovery; D020022:Genetic Predisposition to Disease; D005826:Genetics, Medical; D006801:Humans; D012559:Schizophrenia / Q000235:genetics* / Q000628:therapy*; D057170:Translational Research, Biomedical / Q000379:methods*