title: Modeling the impact of vaccination control strategies on a foot and mouth disease outbreak in the Central United States.
abstract: The central United States (U.S.) has a large livestock population including cattle, swine, sheep and goats. Simulation models were developed to assess the impact of livestock herd types and vaccination on foot and mouth disease (FMD) outbreaks using the North American Animal Disease Spread Model. In this study, potential FMD virus outbreaks in the central region of the U.S. were simulated to compare different vaccination strategies to a depopulation only scenario. Based on data from the U.S. Department of Agriculture National Agricultural Statistics Service, a simulated population of 151,620 livestock operations characterized by latitude and longitude, production type, and herd size was generated. For the simulations, a single 17,000 head feedlot was selected as the initial latently infected herd in an otherwise susceptible population. Direct and indirect contact rates between herds were based on survey data of livestock producers in Kansas and Colorado. Control methods included ring vaccination around infected herds. Feedlots ≥3000 head were either the only production type that was vaccinated or were assigned the highest vaccination priority. Simulated vaccination scenarios included low and high vaccine capacity, vaccination zones of 10 km or 50 km around detected infected premises, and vaccination trigger of 10 or 100 detected infected herds. Probability of transmission following indirect contact, movement controls and contact rate parameters were considered uncertain and so were the subjects of sensitivity analysis. All vaccination scenarios decreased number of herds depopulated but not all decreased outbreak duration. Increased size of the vaccination zone during an outbreak decreased the length of the outbreak and number of herds destroyed. Increased size of the vaccination zone primarily resulted in vaccinating feedlots ≥3000 head across a larger area. Increasing the vaccination capacity had a smaller impact on the outbreak and may not be feasible if vaccine production and delivery is limited. The ability to vaccinate all the production types surrounding an infected herd did not appear as beneficial as priority vaccination of feedlot production types that have high numbers of indirect contacts. Outbreak duration, number of herds depopulated and the effectiveness of vaccination were sensitive to indirect contact transmission probability and movement restrictions. The results of this study will provide information about the impacts of disease control protocols which may be useful in choosing the optimal control methods to meet the goals of rapid effective control and eradication.
authors.affiliation: Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, United States.
authors.forename: Sara W
authors.initials: SW
authors.lastname: McReynolds
authors.affiliation: Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, United States. Electronic address: sandersn@vet.k-state.edu.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Sanderson
authors.affiliation: Epidemiology Research Unit, Scotland's Rural College (SRUC), Inverness, UK.
authors.forename: Aaron
authors.initials: A
authors.lastname: Reeves
authors.affiliation: California Animal Health and Food Safety Laboratory, University of California, Davis, CA, United States.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Hill
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary*; D005536:Foot-and-Mouth Disease / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D015146:Midwestern United States / Q000453:epidemiology; D008962:Models, Theoretical; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D015206:Southwestern United States / Q000453:epidemiology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D014611:Vaccination / Q000662:veterinary*; D014959:Wyoming / Q000453:epidemiology
keywords: Disease control; Disease eradication; Disease modeling; Foot and mouth disease