title: A novel reverse genetics system for human norovirus.
abstract: Human noroviruses cause significant morbidity, mortality, and economic losses worldwide. The inability to grow human noroviruses in cell culture has hampered our collective understanding of virus-host interactions and development of therapeutics. A newly described single-plasmid reverse genetics system for noroviruses has the potential to facilitate basic and applied research.
authors.affiliation: Institute for Virology and Cell Biology, University of Lübeck, 23562 Lübeck, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Taube
authors.affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: cwobus@umich.edu.
authors.forename: Christiane E
authors.initials: CE
authors.lastname: Wobus
mesh_terms: D000818:Animals; D002460:Cell Line; D005822:Genetic Vectors; D006801:Humans; D029322:Norovirus / Q000235:genetics* / Q000254:growth & development*; D010957:Plasmids; D059386:Reverse Genetics / Q000379:methods*
keywords: generation of reporter-tagged viruses; norovirus reverse genetics system