title: Renal cell carcinoma subtype differentiation using single-phase corticomedullary contrast-enhanced CT.
abstract: OBJECTIVE
  To compare multiphase and single-phase corticomedullary contrast-enhanced computed tomographic (CT) imaging in the differentiation of renal cell carcinoma (RCC) subtype.
  
  
  METHODS
  Pathology records were reviewed from January 2008 to March 2013. The final cohort consisted of 79 patients (57 men, 22 women; mean age: 64±13). Quantitative tumor percentage enhancement (TE), cortical enhancement, and tumor-to-cortex enhancement (TCI) indexes were calculated.
  
  
  RESULTS
  Single-phase evaluations showed significantly lower mean TE and TCI for papillary tumors when compared with clear cell and cromophobe tumors (P<.01). Comparison of receiver operating characteristic curve analyses did not show significant differences between both evaluation methods.
  
  
  CONCLUSIONS
  Accuracy of RCC subtype differentiation with single-phase corticomedullary contrast-enhanced CT is comparable to multiphasic imaging.
authors.affiliation: Department of Radiology, Hospital Garcia de Orta, Almada, Portugal; Department of Radiology, Hospital de Faro, Faro, Portugal.
authors.forename: Filipe
authors.initials: F
authors.lastname: Veloso Gomes
authors.affiliation: Department of Radiology, Hospital Garcia de Orta, Almada, Portugal.
authors.forename: António P
authors.initials: AP
authors.lastname: Matos
authors.affiliation: Department of Radiology, Hospital Garcia de Orta, Almada, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Palas
authors.affiliation: Department of Radiology, Hospital da Luz, Lisbon, Portugal.
authors.forename: Vasco
authors.initials: V
authors.lastname: Mascarenhas
authors.affiliation: Department of Radiology, Hospital Espírito Santo, Évora, Portugal.
authors.forename: Vasco
authors.initials: V
authors.lastname: Herédia
authors.affiliation: Department of Radiology, Hospital da Luz, Lisbon, Portugal.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Duarte
authors.affiliation: Department of Radiology, Hospital Garcia de Orta, Almada, Portugal. Electronic address: miguel-ramalho@netcabo.pt.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ramalho
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: CT; RCC subtype differentiation; Renal cell carcinoma; Single-phase