title: [Primary central nervous lymphoma: what is the role for radiotherapy?].
abstract: Primary central nervous system lymphoma is a rare extranodal form of non-Hodgkin lymphoma with an aggressive course and unsatisfactory outcome. Historically, whole-brain radiotherapy was the sole treatment for patients with primary central nervous system lymphoma, with high response rates but typically, this did not result in long-lasting remissions. The addition of high-dose methotrexate-based chemotherapy regimens to whole-brain radiotherapy has significantly improved patients' outcome, but has resulted in a higher incidence of late neurotoxicity, particularly in elderly patients. To date, the role of consolidation radiotherapy is controversial, and some investigators have developed alternative strategies aiming at avoiding immediate irradiation or using a reduced radiotherapy dose to the whole-brain with promising results.
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc. Electronic address: sara.bellefqih@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Bellefqih
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: I
authors.initials: I
authors.lastname: Mezouri
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: J
authors.initials: J
authors.lastname: Khalil
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Bazine
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Diakité
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: H
authors.initials: H
authors.lastname: El Kacimi
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: T
authors.initials: T
authors.lastname: Kebdani
authors.affiliation: Service de radiothérapie, Institut national d'oncologie, avenue Allal El-Fassi, 10100 Rabat, Maroc; Université Mohammed-V Souissi, 10100 Rabat, Maroc.
authors.forename: N
authors.initials: N
authors.lastname: Benjaafar
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000628:therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008727:Methotrexate / Q000627:therapeutic use; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D033581:Stem Cell Transplantation
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate
keywords: Autogreffe de cellules souches; Autologous stem cell transplantation; Chemotherapy; Chimiothérapie; Lymphome primitif du système nerveux central; Neurotoxicity; Neurotoxicité; Primary central nervous system lymphoma; Radiothérapie de l’encéphale en totalité; Whole-brain radiotherapy