title: Severe sepsis and septic shock: clinical overview and update on management.
abstract: Sepsis is among the oldest themes in medicine; however, despite modern advances, it remains a leading cause of death in the United States. Every clinician should be able to recognize the signs and symptoms of sepsis, along with early management strategies, to expeditiously provide appropriate care and decrease resultant morbidity and mortality. This review addresses the definitions, pathogenesis, clinical manifestations, management, and outcomes of patients with sepsis, severe sepsis, and septic shock.
authors.affiliation: College of Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Cawcutt
authors.affiliation: College of Medicine, Mayo Clinic, Rochester, MN. Electronic address: peters.steve@mayo.edu.
authors.forename: Steve G
authors.initials: SG
authors.lastname: Peters
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications*; D001786:Blood Glucose / Q000032:analysis; D002423:Cause of Death / Q000639:trends; D019468:Disease Management; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous; D009181:Mycoses / Q000150:complications*; D010288:Parenteral Nutrition / Q000379:methods / Q000592:standards*; D012121:Respiration, Artificial / Q000379:methods / Q000592:standards*; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012772:Shock, Septic / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D014463:Ultrasonography; D014481:United States / Q000453:epidemiology; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D001786:Blood Glucose; D014662:Vasoconstrictor Agents