title: Links between osteoarthritis and diabetes: implications for management from a physical activity perspective.
abstract: Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist in older adults. Those with T2DM are more susceptible to developing arthritis, which has been traditionally attributed to common risk factors, namely, age and obesity. Alterations in lipid metabolism and hyperglycemia might directly impact cartilage health and subchondral bone, contributing to the development/progression of OA. Adequate management of older persons with both conditions benefits from a comprehensive understanding of the associated risk factors. We discuss common risk factors and emerging links between OA and T2DM, emphasizing the importance of physical activity and the implications of safe and effective physical activity.
authors.affiliation: Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA. Electronic address: spiva@pitt.edu.
authors.forename: Sara R
authors.initials: SR
authors.lastname: Piva
authors.affiliation: Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.
authors.forename: Allyn M
authors.initials: AM
authors.lastname: Susko
authors.affiliation: Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.
authors.forename: Samannaaz S
authors.initials: SS
authors.lastname: Khoja
authors.affiliation: Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Josbeno
authors.affiliation: Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.
authors.forename: G Kelley
authors.initials: GK
authors.lastname: Fitzgerald
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261, USA.
authors.forename: Frederico G S
authors.initials: FG
authors.lastname: Toledo
mesh_terms: D000367:Age Factors; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000628:therapy*; D015444:Exercise; D006801:Humans; D009765:Obesity / Q000150:complications; D010003:Osteoarthritis / Q000150:complications* / Q000628:therapy*; D012307:Risk Factors
keywords: Arthritis; Exercise; Glucose metabolism; Osteoarthritis; Physical activity; Risk factors; Type 2 diabetes