title: Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia.
abstract: This review focuses on the emerging field of non-surgical in-utero therapies in the management of fetal pulmonary hypoplasia and pulmonary hypertension associated with congenital diaphragmatic hernia (CDH). These experimental approaches include pharmacologic as well as stem-cell-based strategies. Current barriers of non-surgical therapies toward clinical translation are emphasized. As the severity of CDH will likely influence the efficacy of any in-utero therapy, the current status of prenatal imaging and the role of novel biomarkers, especially those related to fetal inflammation, are also reviewed.
authors.affiliation: Department of Surgery, University of California San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine, University of California San Francisco, CA, USA.
authors.forename: Cerine
authors.initials: C
authors.lastname: Jeanty
authors.affiliation: Department of Surgery, C.S. Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: Shaun M
authors.initials: SM
authors.lastname: Kunisaki
authors.affiliation: Department of Surgery, University of California San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine, University of California San Francisco, CA, USA. Electronic address: Tippi.Mackenzie@ucsfmedctr.org.
authors.forename: Tippi C
authors.initials: TC
authors.lastname: MacKenzie
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D005260:Female; D046128:Fetal Therapies; D065630:Hernias, Diaphragmatic, Congenital / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D008168:Lung / Q000002:abnormalities*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D033581:Stem Cell Transplantation; D013256:Steroids / Q000627:therapeutic use; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D013256:Steroids; D014801:Vitamin A
keywords: Congenital diaphragmatic hernia; Prenatal pharmacologic treatment; Prenatal stem cell therapy