title: Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis.
abstract: The impact of tissue oxygenation and hypoxia on immune cells has been recognized as a major determinant of host defense and tissue homeostasis. In this review, we will summarize the available data on tissue oxygenation in inflamed and infected tissue and the effect of low tissue oxygenation on myeloid cell function. Furthermore, we will highlight effects of the master regulators of the cellular hypoxic response, hypoxia-inducible transcription factors (HIF), in myeloid cells in antimicrobial defense and tissue homeostasis.
authors.affiliation: Institut für Klinische Mikrobiologie und Hygiene, Universitätsklinikum Regensburg, Germany; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany. Electronic address: Jonathan.Jantsch@ukr.de.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jantsch
authors.affiliation: Medizinische Klinik 4, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany; Translational Research Center, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany. Electronic address: Johannes.Schoedel@uk-erlangen.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schödel
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D018450:Disease Progression; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D000860:Hypoxia / Q000276:immunology* / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010101:Oxygen Consumption; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1; D014157:Transcription Factors
keywords: Hypoxia; Hypoxia-inducible transcription factors; Myeloid cells