title: Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children.
abstract: BACKGROUND
  Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children.
  
  
  METHODS
  A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up.
  
  
  RESULTS
  Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations.
  
  
  CONCLUSIONS
  Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Lausten-Thomsen
authors.forename: Michael
authors.initials: M
authors.lastname: Gamborg
authors.forename: Christine
authors.initials: C
authors.lastname: Bøjsøe
authors.forename: Paula L
authors.initials: PL
authors.lastname: Hedley
authors.forename: Christian Munch
authors.initials: CM
authors.lastname: Hagen
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.forename: Jens-Christian
authors.initials: JC
authors.lastname: Holm
mesh_terms: D000293:Adolescent; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D002648:Child; D047093:Eosinophil Major Basic Protein / Q000032:analysis / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D063766:Pediatric Obesity / Q000097:blood* / Q000628:therapy; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis* / Q000378:metabolism; D011498:Protein Precursors / Q000097:blood; D061217:Weight Reduction Programs
chemical_list: D011498:Protein Precursors; D002097:C-Reactive Protein; D047093:Eosinophil Major Basic Protein; D011266:Pregnancy-Associated Plasma Protein-A