title: Proteins, platelets, and blood coagulation at biomaterial interfaces.
abstract: Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
authors.affiliation: Department of Surgery, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
authors.forename: Li-Chong
authors.initials: LC
authors.lastname: Xu
authors.affiliation: Department of Bioengineering, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
authors.forename: James W
authors.initials: JW
authors.lastname: Bauer
authors.affiliation: Department of Surgery, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States; Department of Bioengineering, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States. Electronic address: csiedlecki@psu.edu.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Siedlecki
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000502:physiology*; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011506:Proteins; D005340:Fibrinogen
keywords: Biological response; Biomaterials; Blood compatibility; Coagulation; Surfaces; Thrombosis