title: Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population.
abstract: OBJECTIVE
  The purpose of this study was to examine the associations between genetic variations in the Protocadherin 15 gene (PCDH15) and the risk to noise induced hearing loss (NIHL) in a Chinese population.
  
  
  METHODS
  A case-control study was conducted with 476 noise-sensitive workers (NIHL) and 475 noise-resistant workers (normal) matched for gender, years of noise exposure, and intensity of noise exposure. 13 tag single-nucleotide polymorphisms in PCDH15 were genotyped using nanofluidic dynamic arrays on the Fluidigm platform. Multiple logistic regression was used to analyze the associations of genetic variations of PCDH15 with NIHL adjusted by age, smoking/drinking status, and cumulative noise exposure and their interactions with noise exposure.
  
  
  RESULTS
  The allele frequency and genotypes of rs1104085 were significantly associated with the risk of NIHL(P=0.009 and 0.005 respectively ). The subjects carrying variant alleles (CT or CC) of rs11004085 had a decreased the risk for NIHL (adjusted odds ratio=0.587, 95% confidence interval 0.409-0.842) compared with subjects who had the wild-type (TT) homozygotes. The interactions were found between the SNPs of rs1100085, rs10825122, rs1930146, rs2384437, rs4540756, and rs2384375 and noise exposure.
  
  
  CONCLUSIONS
  Genetic variations of PCDH15 and their interactions with occupational noise exposure are associated with genetic susceptibility to NIHL and modify the risk of noise induced hearing loss.
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, Zhejiang, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Zhangping
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Hangzhou Prevention and Treatment for Occupational Diseases, Hangzhou 310014, Zhejiang, PR China.
authors.forename: Yuxian
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Yongkang Center for Disease Control and Prevention, Yongkang 321304, PR China.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Fang
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, PR China.
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Yongkang Center for Disease Control and Prevention, Yongkang 321304, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, PR China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, Zhejiang, PR China. Electronic address: zhuym@zju.edu.cn.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000367:Age Factors; D000428:Alcohol Drinking; D000070585:Cadherin Related Proteins; D015820:Cadherins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006317:Hearing Loss, Noise-Induced / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D016273:Occupational Exposure; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012907:Smoking
chemical_list: C498835:CDHR15, human; D000070585:Cadherin Related Proteins; D015820:Cadherins
keywords: Genetic susceptibility; Noise exposure; Protocadherin 15/PCDH15; Single-nucleotide polymorphism/SNP