title: Process optimization of microencapsulation of curcumin in γ-polyglutamic acid using response surface methodology.
abstract: The aim of this study was to develop an optimal microencapsulation method for an oil-soluble component (curcumin) using γ-PGA. The results show that Span80 significantly enhances the encapsulation efficiency (EE) of γ-Na(+)-PGA microcapsules. Therefore, the effects of γ-Na(+)-PGA, curcumin and Span80 concentration on EE of γ-Na(+)-PGA microcapsules were studied by means of response surface methodology (RSM). It was found that the optimal microencapsulation process is achieved by using γ-Na(+)-PGA 6.05%, curcumin 15.97% and Span80 0.61% with a high EE% (74.47 ± 0.20%). Furthermore, the models explain 98% of the variability in the responses. γ-Na(+)-PGA seems to be a good carrier for the encapsulation of curcumin. In conclusion, this simple and versatile approach can potentially be applied to the microencapsulation of various oil-soluble components for food applications.
authors.affiliation: Department of Bioindustry Technology, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China.
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Ko
authors.affiliation: Department of Bioindustry Technology, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China.
authors.forename: Chao-Kai
authors.initials: CK
authors.lastname: Chang
authors.affiliation: Department of Hospitality Management, Mingdao University, 396 Wen-Hua Rd, Peetow, Chang-Hua, Taiwan, Republic of China.
authors.forename: Hsiu-Ju
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Wei Teh Flavour & Fragrance Biotechnology Corp., 95, Sec.3, Jhongshan Rd., Dacun, Chang-Hua, Taiwan, Republic of China.
authors.forename: Shian-Jen
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China. Electronic address: welson@mail.dyu.edu.tw.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Hsieh
mesh_terms: D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology; D004339:Drug Compounding / Q000379:methods*; D008962:Models, Theoretical; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
chemical_list: D011108:Polymers; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D003474:Curcumin
keywords: Curcumin; Encapsulation efficiency; Poly-γ-glutamic acid; Response surface methodology