title: Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes.
abstract: Traditionally, IBD diagnosis is based on clinical, radiological, endoscopic, and histological criteria. Biomarkers are needed in cases of uncertain diagnosis, or to predict disease course and therapeutic response. No guideline recommends the detection of antibodies (including ASCA and ANCA) for diagnosis or prognosis of IBD to date. However, many recent data suggest the potential role of new serological markers (anti-glycan (ACCA, ALCA, AMCA, anti-L and anti-C), anti-GP2 and anti-GM-CSF Ab). This review focuses on clinical utility of these new serological markers in diagnosis, prognosis and therapeutic monitoring of IBD. Literature review of anti-glycan, anti-GP2 and anti-GM-CSF Ab and their impact on diagnosis, prognosis and prediction of therapeutic response was performed in PubMed/MEDLINE up to June 2014. Anti-glycan, anti-GP2 and anti-GM-CSF Ab are especially associated with CD and seem to be correlated with complicated disease phenotypes even if results differ between studies. Although anti-glycan Ab and anti-GP2 Ab have low sensitivity in diagnosis of IBD, they could identify a small number of CD patients not detected by other tests such as ASCA. Anti-glycan Abs are associated with a progression to a more severe disease course and a higher risk for IBD-related surgery. Anti-GP2 Ab could particularly contribute to better stratify cases of pouchitis. Anti-GM-CSF Ab seems to be correlated with disease activity and could help predict relapses. These new promising biomarkers could particularly be useful in stratification of patients according to disease phenotype and risk of complications. They could be a valuable aid in prediction of disease course and therapeutic response but more prospective studies are needed.
authors.affiliation: Laboratory of Immunology and Immunomonitoring, CIC 1408 INSERM, GIMAP EA3064, University Hospital of Saint-Etienne, France.
authors.forename: J
authors.initials: J
authors.lastname: Bonneau
authors.affiliation: Laboratory of Immunology, UMR 5163, CNRS-UJF, University of Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Dumestre-Perard
authors.affiliation: Laboratory of Immunology and Immunomonitoring, CIC 1408 INSERM, GIMAP EA3064, University Hospital of Saint-Etienne, France.
authors.forename: M
authors.initials: M
authors.lastname: Rinaudo-Gaujous
authors.affiliation: Laboratory of Immunology and Immunomonitoring, CIC 1408 INSERM, GIMAP EA3064, University Hospital of Saint-Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Genin
authors.affiliation: Department of Gastroenterology, The Alfred Hospital, Melbourne, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Sparrow
authors.affiliation: Department of Gastroenterology, University of Saint-Etienne, France.
authors.forename: X
authors.initials: X
authors.lastname: Roblin
authors.affiliation: Laboratory of Immunology and Immunomonitoring, CIC 1408 INSERM, GIMAP EA3064, University Hospital of Saint-Etienne, France. Electronic address: stephane.paul@chu-st-etienne.fr.
authors.forename: S
authors.initials: S
authors.lastname: Paul
mesh_terms: D000906:Antibodies / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D058851:GPI-Linked Proteins / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D015415:Biomarkers; C489339:GP2 protein, human; D058851:GPI-Linked Proteins; D011134:Polysaccharides; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: Crohn's disease; GM-CSF; GP2; Glycan; IBD; Ulcerative colitis