title: Primary oral non-Hodgkin's lymphoma - A clinicopathologic study with immunohistochemical analysis.
abstract: BACKGROUND
  Non-Hodgkin's lymphoma (NHL) is a group of highly diverse malignancies whose prognosis depends on the histologic type and associated factors like HIV positivity.
  
  
  OBJECTIVE
  The aim of this study was to evaluate eight cases of NHL for their histologic type and HIV positivity, since both are major prognostic factors for NHL.
  
  
  METHODS
  Eight cases of primary NHL of the oral cavity were evaluated for age, sex, clinical presentation, and the histologic type, along with immunohistochemistry. These cases were also evaluated for HIV positivity.
  
  
  METHODS
  NHL cases which were diagnosed through the dental OPD and subsequent biopsy procedure were chosen. The patient data, including age, sex, location, clinical presentation, radiographic presentation, metastasis, and histologic subtype, according to the World Health Organization (WHO) classification were tabulated. Immunohistochemical markers were used to confirm the cell type. CD20 and CD3 were used for B cell and T cell, respectively. Subsequent western blot analysis was carried out for HIV detection.
  
  
  RESULTS
  75% of the NHL was of B-cell type; of this, 83% was found to be diffuse large B-cell lymphoma, which is an aggressive variant. 62.5% of cases were found to be HIV positive.
  
  
  CONCLUSIONS
  This study emphasizes the need for HIV investigation in NHL cases and the need to determine the histologic type, both of which significantly affect the treatment outcome and prognosis.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Bangalore Institute of Dental Sciences and Hospital, Lakkasandra, Bangalore, India.
authors.forename: Dominic
authors.initials: D
authors.lastname: Augustine
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vinayaka Missions Sankarachariyar Dental College and Hospital, Ariyanoor, Salem, Tamil Nadu, India.
authors.forename: Bala
authors.initials: B
authors.lastname: Sekar
authors.affiliation: Department of Oral Medicine and Radiology, Vinayaka Missions Sankarachariyar Dental College and Hospital, Ariyanoor, Salem, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Thiruneervannan
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vinayaka Missions Sankarachariyar Dental College and Hospital, Ariyanoor, Salem, Tamil Nadu, India.
authors.forename: Murali
authors.initials: M
authors.lastname: Sundhar
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vinayaka Missions Sankarachariyar Dental College and Hospital, Ariyanoor, Salem, Tamil Nadu, India.
authors.forename: Donga Vijay Kumar
authors.initials: DV
authors.lastname: Reddy
authors.affiliation: Department of Oral and Maxillofacial Pathology, M. S. Ramaiah Dental College and Hospital, M. S. Ramaiah Educational Campus MSRIT Post, MSR Nagar, Bangalore, India.
authors.forename: Shankar Gouda
authors.initials: SG
authors.lastname: Patil
keywords: HIV; non-Hodgkin's lymphoma; oral cavity