title: International trends in patient selection for elective endovascular aneurysm repair: sicker patients with safer anatomy leading to improved 1-year survival.
abstract: BACKGROUND
  To review the trends in patient selection and early death rate for patients undergoing elective endovascular repair of infrarenal abdominal aortic aneurysms (EVAR) in 3 countries. For this study, audit data from 4,163 patients who had undergone elective infrarenal EVAR were amalgamated. The data originated from Australia, Canada (Ontario), and England (London, Cambridge, and Leicester).
  
  
  METHODS
  Statistical analyses were undertaken to determine whether patient characteristics and early death rate varied between and within study groups and over time. The study design was retrospective analysis of data collected prospectively between 1999 and 2012.
  
  
  RESULTS
  One-year survival improved over time (P = 0.0013). Canadian patients were sicker than those in Australia or England (P < 0.001). American Society of Anesthesiologists classification (ASA) increased over time across all countries although more significantly in Canada. Age at operation remained constant, although older patients were treated more recently in London (P < 0.001). English centers treated larger aneurysms compared with Australia and Canada (P < 0.001). Australian centers treated a much larger proportion of aneurysms that were <55 mm than other countries. Preoperative creatinine levels decreased over time for all countries and centers (P < 0.001). Infrarenal neck angles have significantly decreased over time (P < 0.001). Recent data from London (UK) showed that operations were performed on longer (P < 0.001) and wider (P < 0.001) infrarenal necks than elsewhere.
  
  
  CONCLUSIONS
  In this international comparison, several trends were noted including improved 1-year survival despite declining patient health (as measured by increasing ASA status). This may reflect greater knowledge regarding EVAR that centers from different countries have gained over the last decade and improved medical management of patients with aneurysmal disease.
authors.affiliation: Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia. Electronic address: robert.fitridge@adelaide.edu.au.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Fitridge
authors.affiliation: Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: Margaret
authors.initials: M
authors.lastname: Boult
authors.affiliation: Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: Clare
authors.initials: C
authors.lastname: Mackillop
authors.affiliation: Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: Tania
authors.initials: T
authors.lastname: De Loryn
authors.affiliation: Mathematics, Informatics and Statistics, CSIRO, Australia.
authors.forename: Mary
authors.initials: M
authors.lastname: Barnes
authors.affiliation: Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: Prue
authors.initials: P
authors.lastname: Cowled
authors.affiliation: St George's Vascular Institute, St George's Hospital, London, UK.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Thompson
authors.affiliation: St George's Vascular Institute, St George's Hospital, London, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Holt
authors.affiliation: St George's Vascular Institute, St George's Hospital, London, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Karthikesalingam
authors.affiliation: Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Sayers
authors.affiliation: Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Choke
authors.affiliation: Cambridge Vascular Unit, Cambridge University Hospitals, Cambridge, UK.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Boyle
authors.affiliation: Division of Vascular Surgery, London Health Sciences Centre, London, Canada.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Forbes
authors.affiliation: Division of Vascular Surgery, London Health Sciences Centre, London, Canada.
authors.forename: Teresa V
authors.initials: TV
authors.lastname: Novick
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D001315:Australia; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality / Q000639:trends*; D017558:Elective Surgical Procedures; D057510:Endovascular Procedures / Q000009:adverse effects / Q000401:mortality / Q000639:trends*; D004739:England; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D018579:Patient Selection; D010818:Practice Patterns, Physicians' / Q000639:trends*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome