title: Obsessive-compulsivity and working memory are associated with differential prefrontal cortex and insula activation in adolescents with a recent diagnosis of an eating disorder.
abstract: The role of rumination at the beginning of eating disorder (ED) is not well understood. We hypothesised that impulsivity, rumination and restriction could be associated with neural activity in response to food stimuli in young individuals with eating disorders (ED). We measured neural responses with functional magnetic resonance imaging (fMRI), tested working memory (WM) and administered the eating disorders examination questionnaire (EDE-Q), Barratt impulsivity scale (BIS-11) and obsessive-compulsive inventory (OCI-R) in 15 adolescent females with eating disorder not otherwise specified (EDNOS) (mean age 15 years) and 20 age-matched healthy control females. We found that EDNOS subjects had significantly higher scores on the BIS 11, EDE-Q and OCI-R scales. Significantly increased neural responses to food images in the EDNOS group were observed in the prefrontal circuitry. OCI-R scores in the EDNOS group also significantly correlated with activity in the prefrontal circuitry and the cerebellum. Significantly slower WM responses negatively correlated with bilateral superior frontal gyrus activity in the EDNOS group. We conclude that ruminations, linked to WM, are present in adolescent females newly diagnosed with EDNOS. These may be risk factors for the development of an eating disorder and may be detectable before disease onset.
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden; Deptartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa. Electronic address: drsamanthabrooks@gmail.com.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Brooks
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Linda
authors.initials: L
authors.lastname: Solstrand Dahlberg
authors.affiliation: Department of Women׳s and Children׳s Health, Uppsala University, Uppsala, Sweden.
authors.forename: Ingemar
authors.initials: I
authors.lastname: Swenne
authors.affiliation: Department of Women׳s and Children׳s Health, Uppsala University, Uppsala, Sweden.
authors.forename: Marianne
authors.initials: M
authors.lastname: Aronsson
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Zarei
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Lina
authors.initials: L
authors.lastname: Lundberg
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Josefin A
authors.initials: JA
authors.lastname: Jacobsson
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Mathias
authors.initials: M
authors.lastname: Rask-Andersen
authors.affiliation: Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Sweden.
authors.forename: Helena
authors.initials: H
authors.lastname: Salonen-Ros
authors.affiliation: Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Sweden.
authors.forename: Agneta
authors.initials: A
authors.lastname: Rosling
authors.affiliation: Department of Radiology, Uppsala University, Uppsala, Sweden.
authors.forename: Elna-Marie
authors.initials: EM
authors.lastname: Larsson
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000503:physiopathology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology*
keywords: EDNOS; Eating disorders; Impulsivity; Neural correlates; OCD; Working-memory