title: Steroids for acute respiratory distress syndrome?
abstract: The development and severity of acute respiratory distress syndrome (ARDS) are closely related to dysregulated inflammation, and the duration of ARDS and eventual outcomes are related to persistent inflammation and abnormal fibroproliferation. Corticosteroids are potent modulators of inflammation and inhibitors of fibrosis that have been used since the first description of ARDS in attempts to improve outcomes. There is no evidence that corticosteroids prevent the development of ARDS among patients at risk. High-dose and short-course treatment with steroids does not improve the outcomes of patients with ARDS. Additional studies are needed to recommend treatment with steroids for ARDS.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Mailstop 359762, Seattle, WA 98104, USA. Electronic address: cterrlee@uw.edu.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Hough
mesh_terms: D004334:Drug Administration Schedule; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids
keywords: ARDS; Corticosteroids; Outcomes; Prevention; Treatment