title: Resolved P-metalated nucleoside phosphoramidites.
abstract: The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.
authors.affiliation: Department of Chemistry, Bucknell University , Lewisburg, Pennsylvania 17837, United States.
authors.forename: Erica J
authors.initials: EJ
authors.lastname: Miller
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Garcia
authors.forename: Erin C
authors.initials: EC
authors.lastname: Holahan
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Ciccarelli
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Bergin
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Casino
authors.forename: Tyler L
authors.initials: TL
authors.lastname: Bogaczyk
authors.forename: Michael R
authors.initials: MR
authors.lastname: Krout
authors.forename: Peter M
authors.initials: PM
authors.lastname: Findeis
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockland
mesh_terms: D019281:Dimerization; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D009943:Organophosphorus Compounds; D009944:Organoplatinum Compounds; C434331:phosphoramidite