title: Regulation of Flavivirus RNA synthesis and replication.
abstract: RNA synthesis and replication of the members of the Flavivirus genus (including dengue, West Nile and Japanese encephalitis viruses) is regulated by a wide variety of mechanisms and actors. These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other than RNA synthesis, regulatory interactions with other viral and host proteins within the replication complex (RC), and regulatory elements within the RNA genome itself. In this review, we discuss our current knowledge of the multiple levels at which Flavivirus RNA synthesis is controlled. We aim to bring together two active research fields: the structural and functional biology of individual proteins of the RC and the impressive wealth of knowledge acquired regarding the viral genomic RNA.
authors.affiliation: Aix-Marseille Université, AFMB UMR 7257, 13288 Marseille, France; CNRS, AFMB UMR 7257, 13288 Marseille, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Selisko
authors.affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
authors.forename: Chunling
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Harris
authors.affiliation: Aix-Marseille Université, AFMB UMR 7257, 13288 Marseille, France; CNRS, AFMB UMR 7257, 13288 Marseille, France. Electronic address: Bruno.Canard@afmb.univ-mrs.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Canard
mesh_terms: D005416:Flavivirus / Q000235:genetics* / Q000502:physiology*; D015967:Gene Expression Regulation, Viral; D054884:Host-Pathogen Interactions; D012367:RNA, Viral / Q000096:biosynthesis*; D014779:Virus Replication
chemical_list: D012367:RNA, Viral