title: Diels-Alder adducts with PTP1B inhibition from Morus notabilis.
abstract: Eight Diels-Alder adducts, morbilisins A-H (1-8), a known analogue, chalcomoracin (9), together with eleven known flavonoids and 2-arylbenzofurans, were isolated from the leaves of Morus notabilis. Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, MS, and ECD data. Compounds 1, 5, and 7-9 showed inhibition against PTP1B phosphatase activity in vitro.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, PR China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Gao
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, PR China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, PR China.
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, PR China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yu
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, PR China. Electronic address: ajhou@shmu.edu.cn.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*
chemical_list: D001572:Benzofurans; D005419:Flavonoids; C550211:chalcomoracin; C000598228:morbilisin; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Diels–Alder adducts; Moraceae; Morbilisins A–H; Morus notabilis; Protein tyrosine phosphatase 1B