title: Onset of hypertension during pregnancy is associated with long-term worse blood pressure control and adverse cardiac remodeling.
abstract: Up to 20% of women with hypertensive pregnancy disorders might persist with chronic hypertension. This study compared clinical and echocardiographic features between women whose hypertension began as hypertensive pregnancy disorders (PH group) and women whose diagnosis of hypertension did not occur during pregnancy (NPH group). Fifty PH and 100 NPH women were cross-sectionally evaluated by clinical, laboratory, and echocardiography analysis, and the groups were matched by duration of hypertension. PH exhibited lower age (46.6 ± 1.4 vs. 65.3 ± 1.1 years; P < .001), but higher systolic (159.8 ± 3.9 vs. 148.0 ± 2.5 mm Hg; P = .009) and diastolic (97.1 ± 2.4 vs. 80.9 ± 1.3 mm Hg; P < .001) blood pressure than NPH, although used more antihypertensive classes (3.4 ± 0.2 vs. 2.6 ± 0.1; P < .001). Furthermore, PH showed higher left ventricular wall thickness and increased prevalence of concentric hypertrophy than NPH after adjusting for age and blood pressure. In conclusion, this study showed that PH may exhibit worse blood pressure control and adverse left ventricular remodeling compared with NPH.
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Roberto F
authors.initials: RF
authors.lastname: Mesquita
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Muriel
authors.initials: M
authors.lastname: Reis
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Beppler
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Vera Regina
authors.initials: VR
authors.lastname: Bellinazzi
authors.affiliation: Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Mattos
authors.affiliation: Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: José L
authors.initials: JL
authors.lastname: Lima-Filho
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: José A
authors.initials: JA
authors.lastname: Cipolli
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Otavio R
authors.initials: OR
authors.lastname: Coelho-Filho
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: José A
authors.initials: JA
authors.lastname: Pio-Magalhães
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: Andrei C
authors.initials: AC
authors.lastname: Sposito
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
authors.forename: José R
authors.initials: JR
authors.lastname: Matos-Souza
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil; Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: wilnj@fcm.unicamp.br.
authors.forename: Wilson
authors.initials: W
authors.lastname: Nadruz
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis* / Q000188:drug therapy*; D016014:Linear Models; D008134:Long-Term Care; D011247:Pregnancy; D011256:Pregnancy Outcome; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology; D020257:Ventricular Remodeling / Q000502:physiology*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: Echocardiography; concentric hypertrophy; hypertensive pregnancy disorders; left ventricular