title: The evolution of surgical and medical treatment of aortic root aneurysm.
abstract: Since first report of aortic root replacement in 1968, the surgical risk and long term outcome of patients with aortic root aneurysm have been continuously improving. In the last 30 years, the surgical approach is also evolving towards more valve conservation with prophylactical intervention at an earlier clinical stage. Translational research has also led to emerging surgical innovation and new drug therapy. Their efficacies are currently under vigorous clinical trials and evaluations.
authors.affiliation: Oxford Heart Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK, xuyu.jin@ndcls.ox.ac.uk.
authors.forename: Xu Yu
authors.initials: XY
authors.lastname: Jin
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.forename: Mario
authors.initials: M
authors.lastname: Petrou
authors.forename: John R
authors.initials: JR
authors.lastname: Pepper
mesh_terms: D001011:Aorta / Q000601:surgery; D001014:Aortic Aneurysm / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans