title: Facile synthesis of bis(indolyl)methanes catalyzed by α-chymotrypsin.
abstract: A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.
authors.affiliation: Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China. zbxie@ecit.edu.cn.
authors.forename: Zong-Bo
authors.initials: ZB
authors.lastname: Xie
authors.affiliation: Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China. anhuisdz@163.com.
authors.forename: Da-Zhao
authors.initials: DZ
authors.lastname: Sun
authors.affiliation: Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China. gfjiang@ecit.cn.
authors.forename: Guo-Fang
authors.initials: GF
authors.lastname: Jiang
authors.affiliation: Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China. zhgle@ecit.edu.cn.
authors.forename: Zhang-Gao
authors.initials: ZG
authors.lastname: Le
mesh_terms: D000818:Animals; D055162:Biocatalysis; D002417:Cattle; D002625:Chemistry, Organic / Q000379:methods*; D002918:Chymotrypsin / Q000378:metabolism*; D000431:Ethanol / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000138:chemical synthesis* / Q000737:chemistry; D034421:Sus scrofa; D013696:Temperature
chemical_list: D007211:Indoles; D000431:Ethanol; D002918:Chymotrypsin; C117608:alpha-chymotrypsin; D008697:Methane