title: Seroprevalency of transfusion-transmitted infections in first-time volunteer and replacement donors in Tunisia.
abstract: BACKGROUND
  Replacement donors are considered as having a major risk of transmission of infections to recipients mainly by the World Health Organisation.
  
  
  METHODS
  Seroprevalency of HBV, HCV, HIV and syphilis were determined in 19,783 whole blood donations collected in the Tunisian National Blood Transfusion Centre during the year 2010 (12,968 [65.55%] replacement donations and 6815 [34.44%] voluntary blood donations). For HBV, HCV and syphilis, we performed a univariate analysis to determine whether age, sex and type of donation were risk factors, then multivariate logistic regression, to see if these factors were independent.
  
  
  RESULTS
  Mean age of donors was 30.1 years (replacement donors 34.5 years, first time non-remunerated donors 34.5 years, P<0.001). The predominant age group was 30-39 years (35.51%) in replacement donors and 20-29 years (54.15%) in first time non-remunerated donors. Male gender was significantly predominant (73.00% men vs 27.00% women, P<10(-6)). There were significantly more men among replacement donors (82.27% vs 55.38%, P<10(-3)). There were more women in the age groups 18-19 and 20-29 years. Only one HIV seropositive donation was noted in a male first time non-remunerated donor aged 18. Replacement type of donation, male sex and age were three independent risk factors for the HBs Ag carriage. For anti-HCV antibodies and TPHA, only replacement type of donation and age were found out to be risk factors and only age was independent.
  
  
  CONCLUSIONS
  In Tunisia, replacement blood donors were at higher risk of infection transmission, but only for hepatitis B.
authors.affiliation: Centre de traitement des hémophiles, hôpital Aziza-Othmana, place de la Kasbah, Bab Menara, Tunis 1008, Tunisia. Electronic address: rimbenjemia@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Ben Jemia
authors.affiliation: Centre de traitement des hémophiles, hôpital Aziza-Othmana, place de la Kasbah, Bab Menara, Tunis 1008, Tunisia; Service d'hématologie, hôpital Aziza-Othmana, place de la Kasbah, Bab Menara, Tunis 1008, Tunisia; Faculté de médecine de Tunis, université de Tunis El-Manar, rue Djebal-Lakhdar, 1006 Tunis, Tunisia.
authors.forename: E
authors.initials: E
authors.lastname: Gouider
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D001803:Blood Transfusion / Q000191:economics; D019353:Endemic Diseases; D005190:Family; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D060926:Remuneration; D012189:Retrospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013587:Syphilis / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D013588:Syphilis Serodiagnosis; D065227:Transfusion Reaction; D014416:Tunisia; D014766:Viremia / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D014838:Volunteers; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: Blood donors; Donneurs de compensation; Donneurs de sang; Donneurs volontaires; HIV; Hepatitis; Hépatite; Infections transmises par transfusion; Replacement donors; Syphilis; Transfusion-transmitted disease; VIH; Volunteer donors