title: Potential of metabolomics in preclinical and clinical drug development.
abstract: Metabolomics is an upcoming technology system which involves detailed experimental analysis of metabolic profiles. Due to its diverse applications in preclinical and clinical research, it became an useful tool for the drug discovery and drug development process. This review covers the brief outline about the instrumentation and interpretation of metabolic profiles. The applications of metabolomics have a considerable scope in the pharmaceutical industry, almost at each step from drug discovery to clinical development. These include finding drug target, potential safety and efficacy biomarkers and mechanisms of drug action, the validation of preclinical experimental models against human disease profiles, and the discovery of clinical safety and efficacy biomarkers. As we all know, nowadays the drug discovery and development process is a very expensive, and risky business. Failures at any stage of drug discovery and development process cost millions of dollars to the companies. Some of these failures or the associated risks could be prevented or minimized if there were better ways of drug screening, drug toxicity profiling and monitoring adverse drug reactions. Metabolomics potentially offers an effective route to address all the issues associated with the drug discovery and development.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Baldeep
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Prakash
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Ruhela
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address: drbikashus@yahoo.com.
authors.forename: Bikash
authors.initials: B
authors.lastname: Medhi
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D008954:Models, Biological
chemical_list: D015415:Biomarkers
keywords: Drug; Metabolism; Metabolomics; Pharmacology; Toxicology