title: [Behavioral effects during the local activation and blockade of serotonin and dopamine receptors in the frontal cortex in cats in the model with a choice of reinforcements of different value].
abstract: In the model with a choice of reinforcements of different value animals were able to "impulsive" and "self-controlled" behavior with an equal probability. Five adult cats were tested. A local application of agonists of 5-HT(1A) and 5-HT(2A/C) receptors (8-OH-DPAT, DOI) in the frontal cortex have resulted in a significant decrease of the "impulsive" reactions and an increase of omissions. The administration of antagonists of 5-HT(2A/C) receptors (ketanserin) and D1/D2 receptors (SCH 23390, raclopride) have impaired the "impulsive" behavior. However the combined administration of agonists/antagonists of 5-HT(2A/C) receptors and antagonists of D1/D2 receptors have not shown the significant changes in behavior as compared with control experiments. The data showed the realization of the optimal behavior with the "impulsive" and "self-controled" reactions in ambivalent animals requires the involvement of both dopaminergic and serotoninergic systems for the regulation of the activity of neurons in frontal cortex areas.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Gerasimova
authors.forename: A A
authors.initials: AA
authors.lastname: Sidorina
authors.forename: E A
authors.initials: EA
authors.lastname: Kuleshova
authors.forename: G H
authors.initials: GH
authors.lastname: Merzhanova
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage; D000818:Animals; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000008:administration & dosage; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology*; D007175:Impulsive Behavior / Q000187:drug effects / Q000502:physiology*; D007650:Ketanserin / Q000008:administration & dosage; D020891:Raclopride / Q000008:administration & dosage; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
chemical_list: D018491:Dopamine Agonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012701:Serotonin; D020891:Raclopride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; D004298:Dopamine