title: Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.
abstract: Chemical investigation of the cupules of Lithocarpus polystachyus resulted in the identification of four 3,4-seco-homo-cycloartane and one homo-cycloartane derivatives named lithocarpic acids O-S. Their structures were determined based on extensive 1D/2D NMR, IR, MS spectroscopic analyses and chemical methods. Lithocarpic acid O (1) exhibited inhibitory activities on mouse and human isozymes of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC₅₀ values of 0.49 and 1.1 μM, respectively.
authors.forename: Ruo-nan
authors.initials: RN
authors.lastname: Ning
authors.forename: Hong-min
authors.initials: HM
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Ru-jun
authors.initials: RJ
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Zhao
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004365:Drugs, Chinese Herbal; D029962:Fagaceae / Q000737:chemistry*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1