title: Benefits of dynamic susceptibility-weighted contrast-enhanced perfusion MRI for glioma diagnosis and therapy.
abstract: Glioma are the most common supra-tentorial brain tumor in the USA with an estimated annual incidence of 17,000 new cases per year. Dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion MRI noninvasively characterizes tumor biology allowing for the diagnosis and therapeutic monitoring of glioma. This MRI technique utilizes the rapid changes in signal intensity caused by a rapid intravascular bolus of paramagnetic contrast agent to calculate physiologic perfusion metrics. DSC perfusion MRI has increasingly become an integrated part of glioma imaging. The specific aim of this article is to review the benefits of DSC perfusion MRI in the therapy of glioma.
authors.affiliation: Department of Radiology & Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, Long L200B, Box 0628, San Francisco, CA 94143, USA.
authors.forename: Ramon Francisco
authors.initials: RF
authors.lastname: Barajas
authors.forename: Soonmee
authors.initials: S
authors.lastname: Cha
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*
keywords: cerebral blood volume; dynamic susceptibility-weighted contrast-enhanced perfusion MRI; glioblastoma; glioma; imaging genomics; metastasis; molecular imaging; peak height; percentage of signal intensity recovery