title: Cycling with BRCA2 from DNA repair to mitosis.
abstract: Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity.
authors.affiliation: Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Republic of Korea. Electronic address: HL212@snu.ac.kr.
authors.forename: Hyunsook
authors.initials: H
authors.lastname: Lee
mesh_terms: D000818:Animals; D024682:BRCA2 Protein / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics*; D048749:Cytokinesis; D004260:DNA Repair / Q000235:genetics*; D004261:DNA Replication; D006801:Humans; D008938:Mitosis / Q000235:genetics*
chemical_list: D024682:BRCA2 Protein
keywords: BRCA2; Cell cycle; HDR (homology-directed recombination); Replication fork; Spindle assembly checkpoint (SAC)