title: Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.
abstract: Small central pattern generating circuits found in invertebrates have significant advantages for the study of the circuit mechanisms that generate brain rhythms. Experimental and computational studies of small oscillatory circuits reveal that similar rhythms can arise from disparate mechanisms. Animal-to-animal variation in the properties of single neurons and synapses may underly robust circuit performance, and can be revealed by perturbations. Neuromodulation can produce altered circuit performance but also ensure reliable circuit function.
authors.affiliation: Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States. Electronic address: marder@brandeis.edu.
authors.forename: Eve
authors.initials: E
authors.lastname: Marder
authors.affiliation: Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States.
authors.forename: Marie L
authors.initials: ML
authors.lastname: Goeritz
authors.affiliation: Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States.
authors.forename: Adriane G
authors.initials: AG
authors.lastname: Otopalik
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D063226:Central Pattern Generators / Q000502:physiology*; D003198:Computer Simulation; D008959:Models, Neurological