title: Poorer Survival in Stage IB Lung Cancer Patients After Pneumonectomy.
abstract: OBJECTIVE
  Pneumonectomy may be needed in exceptional cases in patients with early stage NSCLC, especially in stage IB. The aim of this study was to evaluate whether overall survival in stage IB (T2aN0M0) NSCLC patients is worse after pneumonectomy.
  
  
  METHODS
  Retrospective study of a series of pathological IB (pIB) patients who underwent either lobectomy or pneumonectomy between 2000 and 2011. The dependent variable was all-cause death. Operative mortality was excluded. The relationship between the age, FEV1%, Charlson index and performance of pneumonectomy variables and the dependent variable were analyzed using a Cox regression. Overall survival for both groups of patients was then plotted in Kaplan-Meier graphs and compared using the log-rank test.
  
  
  RESULTS
  A total of 407 cases were analyzed (373 lobectomies and 34 pneumonectomies). According to Cox regression, age, FEV1% and pneumonectomy were associated with poorer survival (P<.05). Age-adjusted survival and FEV1% showed diminished survival in patients who underwent pneumonectomy (log-rank, P=.0357).
  
  
  CONCLUSIONS
  In stage pIB NSCLC patients, pneumonectomy is associated with poorer survival compared to lobectomy.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España. Electronic address: mery.rodriguez.perez@gmail.com.
authors.forename: María
authors.initials: M
authors.lastname: Rodríguez
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Gómez Hernández
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Nuria M
authors.initials: NM
authors.lastname: Novoa
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aranda
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Jiménez
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Varela
mesh_terms: D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D019990:Perioperative Care; D011013:Pneumonectomy / Q000379:methods / Q000401:mortality* / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000401:mortality; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: Cáncer de pulmón; Early stage; Estadio precoz; Lobectomy; Lobectomía; Lung neoplasms; Neumonectomía; Pneumonectomy; Supervivencia; Survival