title: PIKKs--the solenoid nest where partners and kinases meet.
abstract: The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK. The PIKK kinase domain is encircled by the FAT domain, a helical solenoid that is present in all PIKKs. PIKKs also have an extensive helical solenoid N-terminal to the FAT domain for which there is limited structural information. This N-terminal helical solenoid is essential for binding proteins that associate with the PIKKs to regulate their activity and cellular localization.
authors.affiliation: Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK.
authors.forename: Domagoj
authors.initials: D
authors.lastname: Baretić
authors.affiliation: Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: domi@mrc-lmb.cam.ac.uk.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Williams
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry; D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry; D008322:Mammals; D046912:Multiprotein Complexes / Q000737:chemistry*; D009687:Nuclear Proteins / Q000737:chemistry; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry*; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D058570:TOR Serine-Threonine Kinases / Q000737:chemistry*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D064007:Ataxia Telangiectasia Mutated Proteins; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D058570:TOR Serine-Threonine Kinases; C113829:transformation-transcription domain-associated protein