title: Elevated mean platelet volume is associated with poor short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients.
abstract: OBJECTIVE
  It has been shown that mean platelet volume (MPV) can be used as a prognostic biomarker in some chronic diseases. The aim of the present study is to investigate the possible association between MPV and clinical outcome and prognosis in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) within 4 weeks.
  
  
  METHODS
  This study included 64 patients with HBV-ACLF, 19 chronic hepatitis B (CHB) patients, 27 patients with hepatitis B-related cirrhosis (CR, Child-Pugh A/B), 51 healthy subjects (healthy controls [HC]). The complete blood counts and biochemical examination of blood were obtained after 12h of fasting. In the ACLF group, the relationships between the prognosis and the MPV were analyzed.
  
  
  RESULTS
  At baseline, a statistically significant increase in MPV was shown in patients with ACLF (median 9.5, range 7.1-14.1) compared with HC (8.0, 7.2-11.9, P<0.001), CR (8.4, 5.9-11.1, P<0.001) and CHB (8.3, 7.3-12.0, P<0.001). The MPV value was positively correlated with model of end-stage liver disease (MELD) score and international normalized ratio (INR). The MPV level was significantly increased in nonsurvivors than survivors. High MPV level showed a significantly lower survival rate (P=0.001). Multivariate logistic regression analysis showed that only MPV level was independent factor predicting poor short-term outcomes.
  
  
  CONCLUSIONS
  MPV values at presentation were higher among nonsurvivors than survivors, and this parameter was well correlated with liver function parameters and may be used as a predictor for 4-week mortality rate in patients with HBV-ACLF.
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, 300170 Tianjin, PR China; Department of Hepatology, Tianjin Third Central Hospital, 300170 Tianjin, PR China.
authors.forename: Liyao
authors.initials: L
authors.lastname: Han
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, 300170 Tianjin, PR China; Department of Hepatology, Tianjin Third Central Hospital, 300170 Tianjin, PR China; Tianjin Institute of Hepatobiliary Disease, Tianjin Key laboratory of Artificial Cell, The Third Central Hospital of Tianjin, 300170 Tianjin, PR China. Electronic address: hantaomd@126.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, 300170 Tianjin, PR China; Department of Hepatology, Tianjin Third Central Hospital, 300170 Tianjin, PR China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Nie
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, 300170 Tianjin, PR China; Department of Hepatology, Tianjin Third Central Hospital, 300170 Tianjin, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, 300170 Tianjin, PR China; Department of Hepatology, Tianjin Third Central Hospital, 300170 Tianjin, PR China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Cai
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000097:blood* / Q000821:virology; D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D055815:Young Adult