title: [Effect of thyroid status on the system proteolysis under stress].
abstract: Introduction of merkazolil to in rats (25 mg/kg 20 days), causing reduction of iodine containing thyroid hormones levels (ITH) in the blood, reduces the trypsin-like activity (TLA) and the activity of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-MG) in the liver and blood; in the alarm-stage of stress reaction (1 hour after swimming in a cage) it defines more pronounced than that in euthyroid animals stimulation of proteolysis due to the decline of α1-AT and α2-MG activity, in stage of resistance (48 hours) it prevents the normalization of TLA, α1-AT and α2-MG activity, which took place in the stress at the euthyrosis; in the stage of exhaustion (1 hour of the stress within 10 days) promotes to the most significant activation of the proteolysis owing to profound inhibition of the α1-AT and α2-MG. The introduction of L-thyroxine (1.5-3.0 μg/kg 28 days) does not change the concentration of ITH in the blood and it does not affect the proteolyis system; in the alarm- and exhaustion stages it limits the increase of the TLA, in the stage of re-istance prevents it, eliminating the depression of aα1AT and aα-MG activity. The results demon-trate a new aspect of the participation of ITH in the body anti-stress system --heir effect on pro-ease/inhibitor system.
authors.forename: I V
authors.initials: IV
authors.lastname: Gorodetskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Gusakova
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000494:pharmacology; D059748:Proteolysis / Q000187:drug effects*; D051381:Rats; D013312:Stress, Physiological / Q000187:drug effects*; D013963:Thyroid Hormones / Q000097:blood*; D014357:Trypsin / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000097:blood; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D013956:Antithyroid Agents; D013963:Thyroid Hormones; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D008713:Methimazole; D014357:Trypsin