title: Implications of endodontic-related sinus aspergillosis in a patient treated by infliximab: a case report.
abstract: BACKGROUND
  Sinus aspergillosis is a potential complication after root canal therapy of antral teeth. Indeed, zinc oxide-eugenol cement overfilling in the sinus may promote fungal infection. Moreover, if sinus aspergillosis triggers chronic sinusitis with aspergilloma, it may also lead to invasive phenomena, especially for immunocompromised patients.
  
  
  METHODS
  We reported a sinus aspergillosis case of a patient treated with infliximab (Remicade; Janssen Biologics BV, Leiden, Netherlands). The purpose of this article was to explore the mechanisms of this pathosis, especially the impact of the root canal sealer overextension, which is a contributing factor for fungal infection. The surgical management and the follow-up are also described.
  
  
  RESULTS
  Six months after surgery, the patient showed no clinical signs and presented with a healthy and airy right maxillary sinus on the computed tomography scan.
  
  
  CONCLUSIONS
  In conclusion, prevention and screening of aspergillosis of maxillary sinus may be considered before starting an anti-tumor necrosis factor alpha therapy.
authors.affiliation: UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; UMR 7268 ADES Aix-Marseille Université-EFS-CNRS, Faculté de Médecine de Marseille, Marseille, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Guivarc'h
authors.affiliation: UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; Centre Massilien de la Face, Marseille, France.
authors.forename: Ugo
authors.initials: U
authors.lastname: Ordioni
authors.affiliation: UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; UMR 7268 ADES Aix-Marseille Université-EFS-CNRS, Faculté de Médecine de Marseille, Marseille, France.
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Catherine
authors.affiliation: Centre Massilien de la Face, Marseille, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Campana
authors.affiliation: UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Camps
authors.affiliation: UFR Odontologie de Marseille, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France; Laboratoire Biologie Santé et Nanosciences, UFR Odontologie de Montpellier 1, Montpellier, France. Electronic address: frederic.bukiet@univ-amu.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bukiet
mesh_terms: D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000601:surgery; D006801:Humans; D000069285:Infliximab / Q000627:therapeutic use*; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D008875:Middle Aged; D010254:Paranasal Sinus Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D012387:Root Canal Filling Materials / Q000009:adverse effects; D012390:Root Canal Therapy / Q000009:adverse effects* / Q000379:methods; D015035:Zinc Oxide-Eugenol Cement / Q000009:adverse effects
chemical_list: D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C112894:canals sealer; D000069285:Infliximab
keywords: Aspergillosis; endodontics; maxillary sinusitis; root canal filling; therapeutic use; tumor necrosis factor