title: Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype.
abstract: Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. Both dementia and diabetes mellitus type 2 are independently associated with telomere shortening. We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. Relative telomere length was highest in the control group (Q2=0.91) followed by dementia (Q2=0.48) and dementia with comorbid diabetes mellitus type 2 (Q2=0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P>0.05). The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: lakshmineuroscience@gmail.com.
authors.forename: Lakshmi Narayanan
authors.initials: LN
authors.lastname: Kota
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: srikala.bharath@gmail.com.
authors.forename: Srikala
authors.initials: S
authors.lastname: Bharath
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: meera.purushottam@gmail.com.
authors.forename: Meera
authors.initials: M
authors.lastname: Purushottam
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: paul.pradipp@gmail.com.
authors.forename: Pradip
authors.initials: P
authors.lastname: Paul
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: sivakumar.nimhans@gmail.com.
authors.forename: Palanimuthu Thangaraju
authors.initials: PT
authors.lastname: Sivakumar
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: mat.varg@yahoo.com.
authors.forename: Mathew
authors.initials: M
authors.lastname: Varghese
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: sjain.nimhans@gmail.com.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Jain
mesh_terms: D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D003704:Dementia / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016615:Telomere / Q000235:genetics*; D059506:Telomere Shortening / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4
keywords: Apolipoprotein E4; Dementia with diabetes; Telomere