title: Remote ester group leads to efficient kinetic resolution of racemic aliphatic alcohols via asymmetric hydrogenation.
abstract: A highly efficient method for kinetic resolution of racemic aliphatic alcohols without conversion of the hydroxyl group has been realized; the method involves hydrogenation mediated by a remote ester group and is catalyzed by a chiral iridium complex. This powerful, environmentally friendly method provides chiral δ-alkyl-δ-hydroxy esters and δ-alkyl-1,5-diols in good yields with high enantioselectivities even at extremely low catalyst loading (0.001 mol %).
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D056831:Coordination Complexes; D004952:Esters; D007495:Iridium