title: [Effects of acute normobaric hypoxia on free plasma amino acids metabolism in humans].
abstract: We demonstrated significant changes in levels of several plasma free amino acids--proline, hydroxyproline, glycine, and phenylalanine--in healthy volunteers in response to severe acute normobaric hypoxia (breathing nitrogen-oxygen mixture with 9% of O2). We assume that demonstrated an increase of free proline, hydroxyproline, and glycine in plasma in the 10th minute of hypoxia was caused by increased collagenolysis due to hypoxic activation of matrix metalloproteinases. Significantly increased levels of free phenylalanine in the 10th and 20th minutes of hypoxia were the consequences of autophagy activation. Our results suggest that acute severe normobaric hypoxia has specific effects on plasma free amino acids in healthy humans.
authors.forename: E R
authors.initials: ER
authors.lastname: Boĭko
authors.forename: A A
authors.initials: AA
authors.lastname: Chernykh
authors.forename: N N
authors.initials: NN
authors.lastname: Potolitsyna
authors.forename: É A
authors.initials: ÉA
authors.lastname: Burykh
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Liudinina
authors.forename: N A
authors.initials: NA
authors.lastname: Kaneva
authors.forename: V D
authors.initials: VD
authors.lastname: Shadrina
authors.forename: O I
authors.initials: OI
authors.lastname: Parshukova
authors.forename: L I
authors.initials: LI
authors.lastname: Irzhak
authors.forename: S I
authors.initials: SI
authors.lastname: Soroko
mesh_terms: D000208:Acute Disease; D000328:Adult; D000596:Amino Acids / Q000097:blood*; D017364:Collagenases / Q000097:blood*; D004789:Enzyme Activation; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D008297:Male; D013997:Time Factors
chemical_list: D000596:Amino Acids; D017364:Collagenases