title: Development and evaluation of a sublingual film of the antiemetic granisetron hydrochloride.
abstract: The objective of this study was to develop an oral transmucosal formulation of an antiemetic drug that can not only serve in the active form but also provide a controlled release proﬁle. In this study, sublingual films based on the biodegradable and water-soluble polymers, that is HPMCK-4M and PVPK-30, were developed by the solvent casting method, and were loaded with the antiemetic drug granisetron hydrochloride (granisetron HCl). The entrapment efficiency of the developed formulation was found to be 86%. The in vitro profile showed an instant release of the drug from the sublingual film, in a pattern following the first order kinetics array. The in vivo studies showed that granisetron HCl was delivered in its active state and showed effective results, as compared to its activity in the marketed formulation.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Vani
authors.initials: V
authors.lastname: Kalia
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Gautam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000932:Antiemetics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D006041:Goats; D017829:Granisetron / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D065347:Hypromellose Derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D009060:Mouth Floor; D011145:Polyvinyls / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000932:Antiemetics; D017829:Granisetron; D065347:Hypromellose Derivatives; D011145:Polyvinyls; C488580:poly(vinyl phenyl ketone)
keywords: HPMC-K4M; PVPK-30; granisetron hydrochloride; solvent casting method; sublingual film