title: Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches.
abstract: Research over the past decade has demonstrated substantial interactions between the circadian system and the processes through which alcohol affects behavior and physiology. Here we summarize the results of our collaborative efforts focused on this intersection. Using a combination of in vivo and in vitro approaches, we have shown that ethanol affects many aspects of the mammalian circadian system, both acutely as well as after chronic administration. Conversely, we have shown circadian influences on ethanol consumption. Importantly, we are beginning to delve into the cellular mechanisms associated with these effects. We are also starting to form a picture of the neuroanatomical bases for many of these actions. Finally, we put our current findings into perspective by suggesting new avenues of inquiry for our future efforts.
authors.affiliation: Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Prosser
authors.affiliation: Department of Biological Sciences, Kent State University, Kent, OH 44242, USA.
authors.forename: J David
authors.initials: JD
authors.lastname: Glass
mesh_terms: D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D057906:Circadian Clocks / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D012701:Serotonin / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D012701:Serotonin; D000431:Ethanol; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid
keywords: Circadian rhythms; Ethanol; GABA; Glutamate; Serotonin; Suprachiasmatic nucleus