title: [Non-Hodgkin lymphoma: Excellent results at the expense of the high toxicity of the treatment].
abstract: BACKGROUND
  Lymphomas are the third malignancy in children, and within them non-Hodgkin lymphoma (NHL) accounts for just 7% of cancers in children under 15 years old. Chemotherapy is currently the treatment of choice. The objective of this study is to analyze the toxicity caused by the treatment in pediatric patients diagnosed with NHL.
  
  
  METHODS
  A retrospective study was conducted on patients diagnosed with mature B-cell NHL, treated according to the LMB protocol 2001, from January 2007 to February 2014. Data concerning the diagnosis, treatment and toxicities that developed in the patients during the same period were collected.
  
  
  RESULTS
  A total of 20 mature B-cell NHL cases were diagnosed: 16 Burkitt lymphomas, 2 diffuse large cell lymphomas and 2 mature leukemias. Almost two-thirds (65%) of patients were classified in a high grade stage (iii-iv) at diagnosis. Serious infectious processes, severe myelosuppression, liver abnormalities, and mucositis were the most frequent toxicities. Overall survival was 95% (19/20). One patient died of causes unrelated to the illness.
  
  
  CONCLUSIONS
  Despite the excellent survival rate, most patients diagnosed with NHL mature B cells experience grade iii and iv toxicities during treatment.
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España. Electronic address: mabaenagomez@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Baena-Gómez
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Mora Matilla
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Lassaletta Atienza
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Andión Catalán
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Hernández Marqués
authors.affiliation: Servicio de Hemato-Oncología, Hospital Universitario Niño Jesús, Madrid, España.
authors.forename: L
authors.initials: L
authors.lastname: Madero López
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Children; Linfoma no Hodgkin; Neoplasia; Niños; Non Hodgkin lymphoma; Quimioterapia; Toxicidad; Toxicity