title: Reperfusion therapy in the acute management of ischemic stroke.
abstract: Reperfusion, or restoration of blood flow, is an effective means of reducing disability in the setting of acute stroke. Reperfusion therapies, such as intravenous thrombolysis or endovascular and interventional procedures, fit within the existing stroke system of care. There are currently 4 devices cleared by the Food and Drug Administration for recanalization of arterial occlusion in patients with ischemic stroke. Endovascular device technology and advanced imaging technology continue to evolve with newer devices suggesting greater recanalization success. A new paradigm using advanced imaging to select patients in combination with newer devices is being tested and may lead to great improvements in care.
authors.affiliation: Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Michelle P
authors.initials: MP
authors.lastname: Lin
authors.affiliation: Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Roxanna Todd Hodges Comprehensive Stroke Clinic, University of Southern California, 1520 San Pablo Street, Suite 3000, Los Angeles, CA 90026, USA. Electronic address: sanossia@yahoo.com.
authors.forename: Nerses
authors.initials: N
authors.lastname: Sanossian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply*; D002423:Cause of Death; D002544:Cerebral Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D003299:Cooperative Behavior; D003952:Diagnostic Imaging; D004185:Disability Evaluation; D004632:Emergency Medical Services / Q000458:organization & administration; D057510:Endovascular Procedures / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D033183:Interdisciplinary Communication; D008875:Middle Aged; D015424:Reperfusion / Q000295:instrumentation*; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D014481:United States
keywords: Acute ischemic stroke; American Heart Association; American Stroke Association; Intravenous recombinant tissue plasminogen activator (IV-tPA); Mechanical thrombectomy; Stroke system of care; Thrombolysis in cerebral infarction (TICI score)