title: Factor XII (Hageman) levels in women with recurrent pregnancy loss.
abstract: OBJECTIVE
  To evaluate factor XII levels in women with recurrent pregnancy loss (RPL) in a tertiary referral hospital.
  
  
  METHODS
  Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were included in this retrospective observational study. Women were further grouped according to factor XII levels, as <60% and ≥ 60%.
  
  
  RESULTS
  Mean factor XII level was 109.1 ± 35.7% (range: 9-200). Ninety-three (7.4%) women had factor XII levels < 60%. Mean factor XII level was 44.8 ± 13.1, and levels ranged between 9 and 60 in this group. Only one woman had factor XII level < 10 %. Remaining 1164 (92.6%) women had factor XII levels ≥ 60%. Mean factor XII level was 114.3 ± 31.7, and levels ranged between 60.3 and 200 in this group, while 1015 (72.4%) women had factor XII levels within the normal range (60%-150% [100% = 30 μg/mL]).
  
  
  CONCLUSIONS
  Decreased activity of F-XII was diagnosed in 7.4% of women with RPL. We concluded factor XII deficiency that might be a rare but significant factor for RPL, and should be evaluated in women who are investigated for recurrent pregnancy loss.
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey.
authors.forename: A Seval
authors.initials: AS
authors.lastname: Ozgu-Erdinc
authors.affiliation: Department of Obstetrics and Gynecology, Diyarbakır Women's Health and Children Disease Hospital, Diyarbakır, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Togrul
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Aktulay
authors.affiliation: Department of Biochemistry, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey.
authors.forename: Umran
authors.initials: U
authors.lastname: Buyukkagnici
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey.
authors.forename: Elif Gul
authors.initials: EG
authors.lastname: Yapar Eyi
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D005174:Factor XII / Q000032:analysis*; D005175:Factor XII Deficiency / Q000150:complications; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D005174:Factor XII