title: Retention mechanism of hypercrosslinked polystyrene silica hybrid phase in normal phase chromatography.
abstract: Hypercrosslinked polystyrene phases have been described as quasi-normal phase because they lack discrete polar sites. Retention on the HC-Tol column is investigated using the Snyder-Soczewinski model. Solvent strength of different hexane-solvent binary mobile phase compositions can be predicted with solvent strength of pure dichloromethane (DCM, 0.159), tetrahydrofuran (THF, 0.22), and benzene (0.127). The HC-Tol column is shown to be a localizing adsorptive phase. Also, site-competition delocalization on HC-Tol demonstrates that whatever its adsorption groups are, they are able to participate in lateral interactions.
authors.affiliation: Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2.
authors.forename: Georgi K
authors.initials: GK
authors.lastname: Nedev
authors.affiliation: Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2. Electronic address: charles.lucy@ualberta.ca.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Lucy
mesh_terms: D000327:Adsorption; D002853:Chromatography, Liquid / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D011137:Polystyrenes; D012997:Solvents; D012822:Silicon Dioxide
keywords: Localization; Normal phase chromatography; Retention; Snyder–Soczewinski model; Solvent strength