title: The association between body composition and cystatin C in South Asians: results from the MASALA study.
abstract: While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFRcysC) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFRcysC was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation.
authors.affiliation: Division of Endocrinology and Metabolism, University of California, San Francisco, United States. Electronic address: Arti.Shah@ucsf.edu.
authors.forename: Arti D
authors.initials: AD
authors.lastname: Shah
authors.affiliation: Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, United States.
authors.forename: Heidi
authors.initials: H
authors.lastname: Schmidt
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, United States.
authors.forename: Saunak
authors.initials: S
authors.lastname: Sen
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, United States; Division of General Internal Medicine, San Francisco Veterans Affairs Medical Center, United States.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Shlipak
authors.affiliation: Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, United States; Department of Epidemiology and Biostatistics, University of California, San Francisco, United States.
authors.forename: Alka M
authors.initials: AM
authors.lastname: Kanaya
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000368:Aged; D001208:Asia / Q000208:ethnology; D044466:Asian People; D001823:Body Composition; D002097:C-Reactive Protein / Q000378:metabolism; D002140:California; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000378:metabolism*; D054242:Emigrants and Immigrants; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000503:physiopathology
chemical_list: D055316:Cystatin C; D002097:C-Reactive Protein
keywords: Body composition; Cystatin C; Ectopic fat; South Asian