title: Public-private partnership: a new engine for translational research in neurosciences.
abstract: We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common pathways in biologically defined clinical subgroups. This will require integrated translational neuroscience and international public-private partnerships.
authors.affiliation: The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, King's College London, London SE5 8AF, UK. Electronic address: declan.murphy@kcl.ac.uk.
authors.forename: Declan G M
authors.initials: DG
authors.lastname: Murphy
authors.affiliation: Innovative Medicines Initiative, Brussels 1060, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Goldman
authors.affiliation: The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, King's College London, London SE5 8AF, UK.
authors.forename: Eva
authors.initials: E
authors.lastname: Loth
authors.affiliation: Behavioural Pharmacology and Preclinical Imaging, Roche Pharmaceuticals, Basel 4070, Switzerland.
authors.forename: Will
authors.initials: W
authors.lastname: Spooren
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000628:therapy; D009422:Nervous System Diseases / Q000175:diagnosis / Q000628:therapy; D009488:Neurosciences / Q000379:methods / Q000639:trends; D055818:Public-Private Sector Partnerships; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends