title: Within-host competition among the honey bees pathogens Nosema ceranae and Deformed wing virus is asymmetric and to the disadvantage of the virus.
abstract: Two pathogens co-infecting a common host can either interact positively (facilitation), negatively (competition) or act independently. A correlative study has suggested that two pathogens of the honey bee, Nosema ceranae and Deformed wing virus (DWV), interact negatively within a host (Costa et al., 2011). To test this hypothesis, we sequentially co-infected honey bees with these pathogens in a reciprocally crossed experimental design. Prior establishment in the host ventriculus by N. ceranae inhibited DWV while prior infection by DWV did not impact N. ceranae, highlighting an asymmetry in the competitive interaction between these emerging pathogens.
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, Hoher Weg 8, 06120 Halle (Saale), Germany. Electronic address: vincent.doublet@zoologie.uni-halle.de.
authors.forename: Vincent
authors.initials: V
authors.lastname: Doublet
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, Hoher Weg 8, 06120 Halle (Saale), Germany.
authors.forename: Myrsini E
authors.initials: ME
authors.lastname: Natsopoulou
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, Hoher Weg 8, 06120 Halle (Saale), Germany.
authors.forename: Luise
authors.initials: L
authors.lastname: Zschiesche
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, Hoher Weg 8, 06120 Halle (Saale), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany; School of Biological Sciences, Queen's University Belfast, UK.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Paxton
mesh_terms: D000818:Animals; D001516:Bees / Q000469:parasitology* / Q000821:virology; D054884:Host-Pathogen Interactions; D007304:Insect Viruses / Q000502:physiology*; D016818:Nosema / Q000502:physiology*
keywords: Apis mellifera; DWV; Interaction; Microsporidian; Priority effect