title: Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral Cladiella krempfi.
abstract: Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. jean801023@hotmail.com.
authors.forename: Chi-Jen
authors.initials: CJ
authors.lastname: Tai
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. uvaranichem@gmail.com.
authors.forename: Uvarani
authors.initials: U
authors.lastname: Chokkalingam
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. jack1991106@yahoo.com.tw.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. m6430005@hotmail.com.
authors.forename: Shou-Ping
authors.initials: SP
authors.lastname: Shih
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D066244:Proton Magnetic Resonance Spectroscopy; D013481:Superoxides / Q000378:metabolism
chemical_list: D004224:Diterpenes; C476503:eunicellin; C000599607:krempfielin Q; C000599608:krempfielin R; D013481:Superoxides