title: [Have female flight attendants an over-risk of breast cancer?].
abstract: OBJECTIVE
  The aim of this revue was to estimate the level of breast cancer risk among female flight attendants.
  
  
  METHODS
  The selected articles were taken from the PUBMED database, between January 1st 1995 and December 31st 2013 by the means of the following keywords: "breast cancer", "flight attendants", "airline cabin crew" and "flight personnel". Seventeen articles were finally selected.
  
  
  RESULTS
  The incidence of breast cancer is significantly higher among female flights attendants [standardized incidence ratio (SIR) 1.04-5.24, 95% CI 1.00-17.38]. However, no studies have demonstrated a significant increase of mortality by breast cancer [standardized mortality ratio (SMR) 1.0-1.28, 95% CI 0.54-3.7]. The circadian rhythm disruption through night work and time zones leading to disorder of melatonin secretion just as exposure to cosmic radiation could account for this increase of risk.
  
  
  CONCLUSIONS
  A medical supervision concerning breast cancer for flight attendants is recommended. Additional studies seem to be necessary in order to estimate the additional role of other risk factors, in particular hormonal factor.
authors.affiliation: Unité de sénologie, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France. Electronic address: annesophie.gassmann@gmail.com.
authors.forename: A-S
authors.initials: AS
authors.lastname: Gassmann
authors.affiliation: Service de pathologie professionnelle et médecine du travail, hôpital Civil, hôpitaux universitaires de Strasbourg, 67092 Strasbourg cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez
authors.affiliation: Unité de sénologie, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Mathelin
mesh_terms: D001359:Aviation; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D021081:Chronobiology Disorders / Q000150:complications; D005260:Female; D006801:Humans; D016273:Occupational Exposure; D012307:Risk Factors
keywords: Airline cabin crew; Breast cancer risk; Flight attendants; Flight personnel; Hôtesses de l’air; Personnel de bord; Risque de cancer du sein; Équipage aérien