title: Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer.
abstract: Obstetric outcome of first pregnancies achieved after vitrification and warming oocytes from women being treated for cancer was evaluated. Of a total of 493 women who consulted for fertility preservation, 357 had their oocytes cryopreserved after being diagnosed with cancer, and 11 returned after being cured for assisted reproduction treatments (eight had breast cancer, one Hodgkin lymphoma, one endometrial adenocarcinoma, and one thyroid cancer). The oocyte survival rate was 92.3%, the fertilization rate was 76.6%, and the mean number of embryos transferred was 1.8 ± 0.7. Beta-human chorionic gonadotropin was detected in seven out of the 11 embryo transfers carried out. Four ongoing pregnancies were achieved and delivered at term with normal fetal weight and no major or minor malformations. Women diagnosed with cancer who have their eggs cryopreserved before anti-cancer treatment have good assisted reproductive technology performance and good perinatal outcomes. Cryopreservation of oocytes seems to be a good alternative for fertility preservation in these women.
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Av. del Talgo 68, 28023 Madrid, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Martinez
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Av. del Talgo 68, 28023 Madrid, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Rabadan
authors.affiliation: IVI-Las Palmas, Av. Juan Carlos I, 17 35019, Las Palmas de Gran Canaria, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Domingo
authors.affiliation: IVI-Valencia, Plaza de la Policía Local, 3 46025 Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Cobo
authors.affiliation: IVI-Valencia, Plaza de la Policía Local, 3 46025 Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Av. del Talgo 68, 28023 Madrid, Spain. Electronic address: juan.garcia.velasco@ivi.es.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garcia-Velasco
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005306:Fertilization; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D058989:Vitrification
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human
keywords: fertility preservation; oocyte; perinatal outcome; vitrification