title: Deep venous thrombosis and pulmonary embolism in obese women.
abstract: Obesity increases the risk of venous thromboembolism, and pregnancy also increases the risk, particularly around delivery and in the puerperium. Pregnancy complications, which often involve bed rest in hospital, increase the risk still further. This chapter reviews recent studies aimed at quantifying these risks and discusses the mechanisms linking obesity, pregnancy and thromboembolism. It is now apparent that obesity is a proinflammatory condition that creates a prothrombotic milieu, but as yet little is known about how this interacts with pregnancy. Awareness of interacting risk factors has led to guidelines for risk assessment in pregnancy, and implementation of thromboprophylaxis guidelines has been followed by a dramatic fall in deaths from thromboembolism, which was for many years the leading cause of direct maternal deaths in the UK. This chapter summarises the guidelines on the prevention, diagnosis and treatment of thromboembolism in pregnancy and discusses the next steps to further reduce mortality.
authors.affiliation: 25 Park Lane, Roundhay, Leeds LS8 2EX, UK. Electronic address: j.o.drife@leeds.ac.uk.
authors.forename: James
authors.initials: J
authors.lastname: Drife
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D009765:Obesity / Q000453:epidemiology*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011249:Pregnancy Complications, Cardiovascular; D011644:Puerperal Disorders / Q000453:epidemiology* / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: guidelines; obesity; pregnancy; thromboprophylaxis; treatment; venous thromboembolism