title: Antimicrobial and antioxidant activity evaluation of Co(II), Ni(II), Cu(II) and Zn(II) complexes with 15-thia-3,4,9,10-tetraazabicyclo[10.2.1]pentadeca-1(14),2,10,12-tetraene-5,8-dione.
abstract: A new mixed thia-aza macrocyclic complexes with Schiff base viz. 15-thia-3,4,9,10-tetraazabicyclo[10.2.1]pentadeca-1(14),2,10,12-tetraene-5,8-dione containing transition metals, M = Co(II), Ni(II), Cu(II) and Zn(II) and X = Cl(-), NO3(-), OAc(-), has been synthesized, resulting in the final constitution of 1:1:1 M ratio, by the condensation of succinyldihydrazide and thiophenedicarboxaldehyde. The metal complexes have been investigated with the help of various physico-chemical techniques viz. elemental analyses, magnetic susceptibility, thermal, conductivity measurements, spectral (IR, UV, ESR, NMR and mass) and X-ray diffraction techniques. The low value of molar conductivity indicates the non-electrolytic nature of the complexes and a distorted octahedral geometry has been proposed on the basis of various physico-chemical studies. X-ray diffraction indicates the presence of monoclinic crystal system. The complexes have been investigated for in vitro antibacterial, antifungal and antioxidant activity. All the complexes show moderate to significant activity.
authors.affiliation: Department of Chemistry, National Institute of Technology, Kurukshetra 136 119, India. Electronic address: rathiparveen28@gmail.com.
authors.forename: Parveen
authors.initials: P
authors.lastname: Rathi
authors.affiliation: Department of Chemistry, National Institute of Technology, Kurukshetra 136 119, India.
authors.forename: D P
authors.initials: DP
authors.lastname: Singh
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009532:Nickel / Q000494:pharmacology; D066244:Proton Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D015032:Zinc / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D053961:Azabicyclo Compounds; D001643:Bridged Bicyclo Compounds; D056831:Coordination Complexes; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc
keywords: Antioxidant activity; Biological screening; Coordination complexes; Mass; PXRD