title: [Prophylactic surgery in patients mutated BRCA or high risk: retrospective study of 61 patients in the ICO].
abstract: BACKGROUND
  Genetic predisposition is involved in only 10% of patients with breast cancer. This study was to evaluate the impact of prophylactic surgery.
  
  
  METHODS
  This is a retrospective study of 61 patients who received prophylactic breast surgery. Data collection was carried out through the computer file of the ICO. The inclusion criteria were: patients who benefited from a bilateral prophylactic mastectomy. There were no exclusion criteria. Patients received a satisfaction questionnaire to complete.
  
  
  RESULTS
  Our study included 61 patients, 67% had a history of breast cancer. Bilateral prophylactic surgery was performed in 40 patients. It was made an average of two interventions, 44.3% of them presented postoperative complications, 18% recovery. Forty-three patients were satisfied with the medical information before surgery. The end result matched the expectations of 54.4% and 67.4% of patients would be ready to start. It was found pain associated with breast surgery in 56.5% of patients and almost half reported a change in their sexual life.
  
  
  CONCLUSIONS
  Prophylactic mastectomy is the most effective technique to prevent the risk of breast cancer. The consequences of such an action are important. It is necessary to better select patients who would benefit most from this type of surgery.
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France. Electronic address: anne-sophie.oger@ico.unicancer.fr.
authors.forename: A S
authors.initials: AS
authors.lastname: Oger
authors.affiliation: ICO René-Gauducheau, 44805 Saint-Herblain cedex, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Classe
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: O
authors.initials: O
authors.lastname: Ingster
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: M E
authors.initials: ME
authors.lastname: Morin-Meschin
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: B
authors.initials: B
authors.lastname: Sauterey
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: G
authors.initials: G
authors.lastname: Lorimier
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: R
authors.initials: R
authors.lastname: Wernert
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: N
authors.initials: N
authors.lastname: Paillocher
authors.affiliation: ICO Paul-Papin, 2, rue Moll, 49933 Angers cedex 09, France.
authors.forename: P
authors.initials: P
authors.lastname: Raro
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D065286:Prophylactic Surgical Procedures; D012189:Retrospective Studies
keywords: Chirurgie prophylactique; Complications; Genetic predisposition; Prevention; Prophylactic surgery; Prédisposition génétique; Prévention; Quality of Life; Qualité de vie