title: Within-person variability of urinary bisphenol-A in postmenopausal women.
abstract: We evaluated the within-person variability of urinary BPA levels over two samples collected three years apart in 90 Women's Health Initiative participants. The intraclass correlation coefficient was 0.09 (95% CI 0.01-0.44), indicating high within-participant variability relative to the between-person variation. Concordance of BPA quartile over time was low (31.7%) and was unrelated to demographic, behavioral, or dietary factors. A single, or even several, measurements of BPA may not adequately classify long-term exposure in human studies.
authors.affiliation: Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA. Electronic address: kwreeves@schoolph.umass.edu.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Reeves
authors.affiliation: Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.
authors.forename: Juhua
authors.initials: J
authors.lastname: Luo
authors.affiliation: Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.affiliation: Department of Applied Health Science, Indiana University, Bloomington, IN, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hendryx
authors.affiliation: HealthPartners Institute for Education and Research, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Margolis
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: JoAnn E
authors.initials: JE
authors.lastname: Manson
authors.affiliation: Analytical Biochemistry Shared Resource, University of Hawaii Cancer Center, Honolulu, HI, USA.
authors.forename: Adrian A
authors.initials: AA
authors.lastname: Franke
mesh_terms: D000367:Age Factors; D000368:Aged; D001559:Benzhydryl Compounds / Q000652:urine*; D015992:Body Mass Index; D004032:Diet; D004784:Environmental Monitoring / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010636:Phenols / Q000652:urine*; D015203:Reproducibility of Results; D014481:United States; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol-A; Exposure measurement; Postmenopausal; Variability; Women