title: Serum ischemia-modified albumin and oxidized LDL in cord blood and serum of neonates born to pre-eclamptic mothers.
abstract: BACKGROUND
  We investigated oxidized low-density lipoprotein (OxLDL) and ischemia-modified albumin (IMA) in cord blood and neonatal blood of 7-day-old neonates born to pre-eclamptic and normotensive healthy mothers.
  
  
  METHODS
  The study was performed on 30 neonates born to pre-eclamptic and 20 neonates born to normotensive mothers. IMA and OxLDL were determined on spectrophotometry and ELISA, respectively.
  
  
  RESULTS
  IMA in cord blood was higher in the pre-eclamptic group as compared with the normotensive group, but the difference between the groups was not significant. IMA in neonate venous blood was significantly higher in the pre-eclamptic group than in the normotensive group (P < 0.001). OxLDL in both cord blood and in neonate venous blood was significantly higher in the pre-eclamptic group compared with the normotensive group (P < 0.001). IMA and OxLDL were significantly decreased after delivery in both groups.
  
  
  CONCLUSIONS
  Significantly increased cord blood OxLDL and significantly increased OxLDL and IMA 7 days after birth in neonates born to pre-eclamptic mothers might be an indicator of increased oxidative stress in pre-eclampsia.
authors.affiliation: Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Idris
authors.initials: I
authors.lastname: Mehmetoglu
authors.affiliation: Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.affiliation: Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Toker
authors.affiliation: Division of Neonatology, Department of Pediatrics, Selcuk University Faculty of Medicine, Konya, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Annagür
authors.affiliation: Division of Neonatology, Department of Pediatrics, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Altunhan
authors.affiliation: Department of Biochemistry, Mardin Maternity Hospital, Mardin, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Erbay
authors.affiliation: Division of Neonatology, Department of Pediatrics, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Örs
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D009035:Mothers; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012189:Retrospective Studies; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D012709:Serum Albumin; C561522:ischemia-modified albumin; C099252:oxidized low density lipoprotein; D000075462:Serum Albumin, Human
keywords: cord blood; ischemia-modified albumin; neonate born to pre-eclamptic mother; oxidized low-density lipoprotein; pre-eclampsia