title: [Cerebral venous thrombosis and immune thrombocytopenia in a 7-year-old girl: a fortuitous association?].
abstract: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by autoantibody-mediated peripheral platelet destruction. It is rarely accompanied by thrombosis. Here, we describe a wide cerebral venous thrombosis that occurred at the onset of a primary ITP in a 7-year-old girl. ITP was confirmed by the presence of anti-platelet antibodies. Whether ITP is a risk factor for venous thrombosis is a matter of debate. The platelet microparticles released during the platelet destruction and the interaction between the autoantibodies and the platelet glycoproteins may contribute to platelet activation. Increased risk of thromboembolic events should be considered in all patients with ITP, including children.
authors.affiliation: Service d'onco-immuno-hématopédiatrie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address: mariecot@aol.com.
authors.forename: M
authors.initials: M
authors.lastname: Cotillon
authors.affiliation: Service de neurophysiologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lebas
authors.affiliation: Service de réanimation pédiatrique et néonatale, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: T
authors.initials: T
authors.lastname: Blanc
authors.affiliation: Service d'onco-immuno-hématopédiatrie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.affiliation: Service d'onco-immuno-hématopédiatrie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Vannier
authors.affiliation: Service d'onco-immuno-hématopédiatrie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Buchbinder
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D020246:Venous Thrombosis / Q000150:complications*