title: Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model.
abstract: This article describes the toxicokinetics of perfluorooctane sulfonate (PFOS) in birds under low repeated dosing, equivalent to 0.085 μg/kg per day, representing environmentally realistic exposure conditions. The best fitting was provided by a simple pseudo monocompartmental first-order kinetics model, regulated by two rates, with a pseudo first-order dissipation half-life of 230 days, accounting for real elimination as well as binding of PFOS to non-exchangeable structures. The calculated assimilation efficiency was 0.66 with confidence intervals of 0.64 and 0.68. The model calculations confirmed that the measured maximum concentrations were still far from the steady state situation, which for this dose regime, was estimated at a value of about 65 μg PFOS/L serum achieved after a theoretical 210 weeks continuous exposure. The results confirm a very different kinetics than that observed in single-dose experiments confirming clear dose-related differences in apparent elimination rates in birds, as described for humans and monkeys; suggesting that a capacity-limited saturable process should also be considered in the kinetic behavior of PFOS in birds. Pseudo first-order kinetic models are highly convenient and frequently used for predicting bioaccumulation of chemicals in livestock and wildlife; the study suggests that previous bioaccumulation models using half-lives obtained at high doses are expected to underestimate the biomagnification potential of PFOS. The toxicokinetic parameters presented here can be used for higher-tier bioaccumulation estimations of PFOS in chickens and as surrogate values for modeling PFOS kinetics in wild bird species.
authors.affiliation: Laboratory for Ecotoxicology, INIA, Madrid, Spain.
authors.forename: J V
authors.initials: JV
authors.lastname: Tarazona
authors.affiliation: Toxicology and Pharmacology Department, Veterinary Faculty, UCM, Madrid, Spain. Electronic address: rodfermc@vet.ucm.es.
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez
authors.affiliation: Laboratory for Ecotoxicology, INIA, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Alonso
authors.affiliation: Department of Instrumental Analysis and Environmental Chemistry, Institute of Organic Chemistry, Spanish National Research Council (IQOG-CSIC), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sáez
authors.affiliation: Toxicology and Pharmacology Department, Veterinary Faculty, UCM, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: González
authors.affiliation: Toxicology and Pharmacology Department, Veterinary Faculty, UCM, Madrid, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: San Andrés
authors.affiliation: Department of Instrumental Analysis and Environmental Chemistry, Institute of Organic Chemistry, Spanish National Research Council (IQOG-CSIC), Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Jiménez
authors.affiliation: Toxicology and Pharmacology Department, Veterinary Faculty, UCM, Madrid, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: San Andrés
mesh_terms: D017738:Alkanesulfonic Acids / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000378:metabolism*; D004781:Environmental Exposure; D005466:Fluorocarbons / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D006207:Half-Life; D057230:Limit of Detection; D008297:Male; D015233:Models, Statistical
chemical_list: D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; C076994:perfluorooctane sulfonic acid
keywords: Birds; Elimination half-life; Gallus gallus; PFOS; Toxicokinetics