title: Hematopoietic stem cell transplantation for primary immunodeficiencies.
abstract: Allogeneic hematopoietic stem cell transplantation has been shown to be curative for well-described as well as newly discovered immunodeficiencies. However, it is difficulty to define a universal transplant regimen given the rarity of these disorders and the varied pathophysiology these disorders encompass. This article discusses those primary immunodeficiencies most commonly treated by hematopoietic stem cell transplant and describes the transplant issues specific to these disorders.
authors.affiliation: Hematotherapeutics Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10-CRC Room 6-3752, 10 Centre Drive, Bethesda, MD 20892, USA. Electronic address: ekang@niaid.nih.gov.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Kang
authors.affiliation: Paediatric Immunology Department, Institute of Cellular Medicine, Great North Children's Hospital, c/o Ward 3, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Gennery
mesh_terms: D001782:Blood Donors; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome
keywords: Immune reconstitution; Immunodeficiency; Immunosuppression; Infection; Inflammation