title: Predonation health-related quality of life scores predict time to recovery in hematopoietic stem cell donors.
abstract: The physical reactions to hematopoietic stem cell donation have been extensively studied, but less is known about factors that predict poorer donation experiences. The aim of this prospective study was to examine demographic and health-related quality of life (HRQOL) factors that might be associated with recovery and side effects. We also described the changes in HRQOL during the donation process. In total, 275 peripheral blood stem cell (PBSC) and 37 bone marrow (BM) consecutive donors completed the SF-36 questionnaire predonation and 4 weeks, and 3 months postdonation. Predonation HRQOL markers were the strongest predictors of time to recovery. Poorer predonation physical health was associated with longer recovery (P = .017) and certain side effects in PBSC donors. Poorer predonation mental health was associated with longer recovery in BM donors (P = .03) and pain after PBSC donation (P = .003). Physical HRQOL scores declined significantly from predonation to 4 weeks postdonation. This was shown both for PBSC and BM donors (P < .001 and P = .009, respectively), but the decline was much greater for BM donors. There was a return to predonation HRQOL values 3 months after donation in both groups with values well above the mean of the general population (P < .001).
authors.affiliation: UCL Cancer Institute and Anthony Nolan Research Institute, London, United Kingdom. Electronic address: Annelies.billen@anthonynolan.org.
authors.forename: Annelies
authors.initials: A
authors.lastname: Billen
authors.affiliation: UCL Cancer Institute and Anthony Nolan Research Institute, London, United Kingdom.
authors.forename: J Alejandro
authors.initials: JA
authors.lastname: Madrigal
authors.affiliation: UCL Mental Health Sciences Unit, London, United Kingdom.
authors.forename: Andre
authors.initials: A
authors.lastname: Strydom
authors.affiliation: Department of Medicine, Imperial College London, London, United Kingdom.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Szydlo
authors.affiliation: Department of General Internal Medicine, University of Pittsburgh and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
authors.forename: Galen E
authors.initials: GE
authors.lastname: Switzer
authors.affiliation: UCL Cancer Institute and Anthony Nolan Research Institute, London, United Kingdom; Department of Haematology, Royal Marsden Hospital, London, United Kingdom.
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000523:psychology; D003289:Convalescence / Q000523:psychology*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000523:psychology*; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology / Q000523:psychology; D036102:Peripheral Blood Stem Cell Transplantation / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012107:Research Design; D011795:Surveys and Questionnaires; D013997:Time Factors; D014019:Tissue Donors / Q000523:psychology*
keywords: Bone marrow; Donation experience; Health-related quality of life; Peripheral blood stem cells