title: Long-term uveal and capsular biocompatibility of a new accommodating intraocular lens.
abstract: OBJECTIVE
  To evaluate long-term uveal and capsular biocompatibility of a new accommodating intraocular lens (IOL).
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Bilateral phacoemulsification was performed in 14 rabbits; 1 eye received the accommodating IOL (Fluidvision) and the other received a hydrophobic acrylic control IOL. Slitlamp examinations were performed at postoperative weeks 1 to 4 and months 2, 3, 4, and 6. Six rabbits were humanely killed at 2 months and 8 rabbits at 6 months. After gross examination with the Miyake-Apple view, selected IOLs were removed for implant cytology. All globes were then sectioned and processed for histopathologic examination.
  
  
  RESULTS
  Uveal biocompatibility of study and control IOLs was similar in clinical and pathologic examinations up to 6 months postoperatively. In the study group, anterior capsule opacification appeared absent and posterior capsule opacification (PCO) was significantly less than in the control group. At the gross examination at 6 months, central PCO was 0.8 ± 0.5 (SD) in the study IOLs and 3.7 ± 0.4 in the control IOLs (P < .0001, 2-tailed paired t test). Histopathologic examination confirmed the relative lack of capsule opacification in study eyes compared with controls and the absence of untoward inflammatory reaction or toxicity in all eyes.
  
  
  CONCLUSIONS
  The accommodating IOL maintained an expanded capsular bag secondary to the large size of the haptic elements without significant contact with the anterior capsule. This appeared to prevent overall capsular bag opacification and to retain uveal and capsular biocompatibility.
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Kohl
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Electronic address: liliana.werner@hsc.utah.edu.
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Ford
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Cole
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Shail A
authors.initials: SA
authors.lastname: Vasavada
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Gareth L
authors.initials: GL
authors.lastname: Gardiner
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Rozina
authors.initials: R
authors.lastname: Noristani
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D058442:Capsule Opacification / Q000517:prevention & control*; D005355:Fibrosis / Q000517:prevention & control; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000517:prevention & control*; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008422:Materials Testing; D023421:Models, Animal; D018918:Phacoemulsification; D011474:Prosthesis Design; D011817:Rabbits; D014602:Uvea / Q000473:pathology*; D014605:Uveitis / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials