title: Towards broadly protective polyvalent vaccines against hand, foot and mouth disease.
abstract: Hand, foot, and mouth disease (HFMD) caused by multiple enterovirus infections is a serious health threat to children in the Asia-Pacific region. This article reviews progresses in the development of vaccines for HFMD and discusses the need for polyvalent HFMD vaccines for conferring broad-spectrum protection.
authors.affiliation: Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Shanghai Zerun Biotechnology Co., Ltd., Building 9, 1690 Zhangheng Rd, Zhangjiang, Pudong New District, Shanghai 201203, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tong
authors.affiliation: Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. Electronic address: huangzhong@ips.ac.cn.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Huang
mesh_terms: D001208:Asia; D002675:Child, Preschool; D029821:Enterovirus A, Human / Q000276:immunology*; D006232:Hand, Foot and Mouth Disease / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D007223:Infant; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
keywords: Coxsackievirus A16; Enterovirus 71; Hand, foot, and mouth disease; Polyvalent vaccine