title: Prediction of outcome methods assessing short- and long-term outcome after therapeutic hypothermia.
abstract: Therapeutic hypothermia has significantly changed outcomes for newborns suffering neonatal encephalopathy. Outcome predictors established in the pre-cooling era may not automatically be transferred to the cooling era. This article reviews how the reliability of routinely used outcome predictors has changed. We summarize current knowledge about why this may be the case and when to best obtain and analyze different clinical, biochemical, and imaging outcome markers to predict outcome in cooled asphyxiated newborns.
authors.affiliation: School of Clinical Sciences, University of Bristol, St Michael's Hospital, Bristol, UK; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. Electronic address: hemmen.sabir@med.uni-duesseldorf.de.
authors.forename: Hemmen
authors.initials: H
authors.lastname: Sabir
authors.affiliation: School of Clinical Sciences, University of Bristol, St Michael's Hospital, Bristol, UK; Department of Paediatrics, Imperial College, London, UK.
authors.forename: Frances M
authors.initials: FM
authors.lastname: Cowan
mesh_terms: D001238:Asphyxia Neonatorum / Q000628:therapy*; D004569:Electroencephalography; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D016896:Treatment Outcome
keywords: Amplitude-integrated electroencephalography; Magnetic resonance imaging; Neonatal encephalopathy; Outcome assessment; Therapeutic hypothermia; Ultrasonography