title: Length of life gained with surgical treatment of prostate cancer: A population-based analysis.
abstract: OBJECTIVE
  The aim of this study was to analyse relative survival, excess mortality and gain in life expectancy in men who underwent radical prostatectomy (RP) for localized prostate cancer (PCa) between 1995 and 2011 in Denmark.
  
  
  METHODS
  The study population comprised the complete cohort of 6489 men who underwent RP between 1995 and 2011. Risk of mortality was calculated using a competing risk model. Relative survival, excess mortality rate (EMR) and gain in life expectancy in men undergoing RP were calculated using a matched cohort Danish population based on date of birth and date of surgery.
  
  
  RESULTS
  During follow-up 328 patients died, 109 (33.2%) of PCa and 219 (66.8%) of other causes. The cumulative incidence of PCa mortality was 5.8% [95% confidence interval (CI) 4.4, 7.2] after 10 years. Relative survival was significantly above 1.0 for RP patients, except for high-risk patients. EMR was -9.34 (95% CI -10.56, -8.13) after 10 years, i.e. nine men would die in excess of the general population. Overall, the gain in life expectancy in men undergoing RP compared with the general population was 0.41 years.
  
  
  CONCLUSIONS
  This population-based study demonstrated that the gain in life expectancy with RP compared with the general population in Denmark is minimal.
authors.affiliation: Copenhagen Prostate Cancer Center and.
authors.forename: Martin Andreas
authors.initials: MA
authors.lastname: Røder
authors.forename: Klaus
authors.initials: K
authors.lastname: Brasso
authors.forename: Ea
authors.initials: E
authors.lastname: Rusch
authors.forename: Jørgen
authors.initials: J
authors.lastname: Johansen
authors.forename: Niels Christian
authors.initials: NC
authors.lastname: Langkilde
authors.forename: Helle
authors.initials: H
authors.lastname: Hvarness
authors.forename: Steen
authors.initials: S
authors.lastname: Carlsson
authors.forename: Henrik
authors.initials: H
authors.lastname: Jakobsen
authors.forename: Michael
authors.initials: M
authors.lastname: Borre
authors.forename: Peter
authors.initials: P
authors.lastname: Iversen
mesh_terms: D000328:Adult; D000368:Aged; D003718:Denmark; D006801:Humans; D053208:Kaplan-Meier Estimate; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Competing risk; excess mortality; localized prostate cancer; radical prostatectomy; relative survival; standardized mortality ratio