title: Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study.
abstract: OBJECTIVE
  This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).
  
  
  METHODS
  A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0).
  
  
  RESULTS
  Sixty-four patients were evaluated. The mean age was 42.1±3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (-2.5kg; 71.5 vs. 68.75kg; p-value<0.001), body mass index (-0.9kg/m(2); 24.8 vs. 24.4kg/m(2); p-value<0.001), and serum albumin levels (-0.2g/dL; 3.7 vs. 3.6g/dL; p-value=0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC=-0.72; p-value<0.001) and positively with serum albumin levels (CC=0.56; p-value=0.004) and with high total protein level at discharge (CC=0.53; p-value=0.006).
  
  
  CONCLUSIONS
  Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation.
authors.affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
authors.forename: Erika Elias
authors.initials: EE
authors.lastname: Ferreira
authors.affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil. Electronic address: daianenutri@gmail.com.
authors.forename: Daiane Cristina
authors.initials: DC
authors.lastname: Guerra
authors.affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
authors.forename: Kátia
authors.initials: K
authors.lastname: Baluz
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Wander
authors.initials: W
authors.lastname: de Resende Furtado
authors.affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: da Silva Bouzas
keywords: Hematopoietic stem cell transplantation; Nutritional status; Nutritional therapy