title: Recognition of preclinical and early disease in axial spondyloarthritis.
abstract: In recent years the early identification of axial spondyloarthritis has become a high priority area of research. Evidence that therapy may slow radiographic progression of disease has heightened the importance of recognition of early disease. However, the concept of early axial spondyloarthritis and natural history of early disease are not fully understood. Future strategies to detect early and preclinical disease may incorporate clinical information, radiographic, serologic, and genetic testing. The risks and benefits of screening and early identification of disease need careful consideration.
authors.affiliation: Department of Rheumatology, Royal Hampshire County Hospital, Romsey Road, Winchester 50300PP, UK.
authors.forename: Dinny
authors.initials: D
authors.lastname: Wallis
authors.affiliation: Division of Rheumatology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto M5T 2S8, Ontario, Canada. Electronic address: robert.inman@uhnresearch.ca.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Inman
mesh_terms: D001416:Back Pain / Q000175:diagnosis* / Q000209:etiology; D042241:Early Diagnosis; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D008279:Magnetic Resonance Imaging; D011565:Psoriasis / Q000150:complications; D025242:Spondylarthropathies / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D014605:Uveitis / Q000150:complications
chemical_list: D015796:HLA-B27 Antigen
keywords: Ankylosing spondylitis; Diagnosis; Genetic testing; Magnetic resonance imaging; Serology