title: Human-chimpanzee alignment: ortholog exponentials and paralog power laws.
abstract: Genomic subsequences conserved between closely related species such as human and chimpanzee exhibit an exponential length distribution, in contrast to the algebraic length distribution observed for sequences shared between distantly related genomes. We find that the former exponential can be further decomposed into an exponential component primarily composed of orthologous sequences, and a truncated algebraic component primarily composed of paralogous sequences.
authors.affiliation: Physics and Biology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan. Electronic address: kgao@oist.jp.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.affiliation: Physics and Biology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan. Electronic address: jnthnmllr@oist.jp.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D017124:Conserved Sequence; D016678:Genome; D015233:Models, Statistical; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000145:classification / Q000235:genetics; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000706:statistics & numerical data; D012689:Sequence Homology, Nucleic Acid; D006801:Humans
keywords: Evolution; Exponential and Power-law; Genomic alignment; Length distribution; Orthology and paralogy