title: The ventral fiber pathway for pantomime of object use.
abstract: The current concept of a dual loop system of brain organization predicts a domain-general dual-pathway architecture involving dorsal and ventral fiber connections. We investigated if a similar dichotomy of brain network organization applies for pantomime (P) and imitation of meaningless gestures (I). Impairments of these tasks occur after left hemispheric brain lesions causing apraxia. Isolated impairments and double-dissociations point towards an anatomical segregation. Frontal and parietal areas seem to contribute differently. A special role of the inferior frontal gyrus and underlying fiber pathways was suggested recently. Using a combined fMRI/DTI-approach, we compared the fiber pathway architecture of left hemispheric frontal, temporal and parietal network components of pantomime and imitation. Thereby, we separated object effects from pantomime-specific effects. P and I both engage a fronto-temporo-parietal network of cortical areas interconnected by a dorsal fiber system (superior longitudinal fascicle) for direct sensory-motor interactions. The pantomime-specific effect additionally involved the triangular part of the inferior frontal gyrus, the middle temporal gyrus, the inferior parietal cortex and the intraparietal sulcus, interconnected by ventral fibers of the extreme capsule, likely related to higher-order conceptual and semantic operations. We discuss this finding in the context of the dual loop model and recent anatomical concepts.
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany. Electronic address: magnus-sebastian.vry@uniklinik-freiburg.de.
authors.forename: Magnus-Sebastian
authors.initials: MS
authors.lastname: Vry
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Tritschler
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Moritz-Klinik, Bad Klosterlausnitz, Germany; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Germany.
authors.forename: Farsin
authors.initials: F
authors.lastname: Hamzei
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany.
authors.forename: Michel
authors.initials: M
authors.lastname: Rijntjes
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany.
authors.forename: Christoph P
authors.initials: CP
authors.lastname: Kaller
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Hoeren
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany.
authors.forename: Roza
authors.initials: R
authors.lastname: Umarova
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany.
authors.forename: Volkmar
authors.initials: V
authors.lastname: Glauche
authors.affiliation: Chair of Movement Science, School of Sport and Health Sciences, Technical University Munich, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hermsdoerfer
authors.affiliation: Clinic for Neuropsychology, Hospital Munich-Bogenhausen, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Goldenberg
authors.affiliation: Medical Physics, Department of Radiology, University Medical Center Freiburg, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Hennig
authors.affiliation: Freiburg Brain Imaging, University Medical Center Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Germany.
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D005868:Gestures; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity; D009415:Nerve Net; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult
keywords: DTI; Dual loop model; Fiber network; Imitation; Pantomime; fMRI