title: Sentinel node biopsy for the management of early stage endometrial cancer: long-term results of the SENTI-ENDO study.
abstract: OBJECTIVE
  We report the long-term results of the SENTI-ENDO study evaluating the impact of sentinel lymph node (SLN) biopsy on management and survival in patients with early stages of endometrial cancer (EC).
  
  
  METHODS
  Patients with FIGO stage I-II EC underwent pelvic SLN biopsy after cervical dual injection (technetium and patent blue) and systematic pelvic node dissection. This study is a secondary endpoint reporting the long-term recurrence free survival (RFS) and the impact of the SLN procedure on adjuvant therapies.
  
  
  RESULTS
  The median follow-up was 50 months (range: 3-77 months). Eighteen of the 125 patients (14.4%) experienced a recurrence. The 50-month recurrence-free survival (RFS) was 84.7% with no difference between patients with and without detected SLN (p = 0.09). Among patients with detected SLN (111), no difference in RFS was observed between those with and without positive SLN (p = 0.5). In the whole population, adjuvant therapy was performed in low-, intermediate- and high-risk groups in 31 of 64 patients (48.4%), 28 of 37 patients (75.7%) and 14 of 17 patients (82.3%), respectively (p = 0.0001). For the 111 patients with detected SLN, EBRT was performed in 27 of the 89 with negative SLN and in 11 of the 14 with positive SLN (p = 0.001). Chemotherapy was performed more frequently in patients with positive SLN (6/12, 50%) than in patients with negative SLN (7/56, 12.5%) (p = 0.009).
  
  
  CONCLUSIONS
  Our results support the impact of SLN biopsy on surgical management and indications for adjuvant therapies. Further studies are required to assess the clinical impact of the SLN biopsy in early stage EC.
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France.
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
authors.affiliation: Department of Obstetrics and Gynecology, Croix Rousse University Hospital, Lyon, France.
authors.forename: Gil
authors.initials: G
authors.lastname: Dubernard
authors.affiliation: Department of Gynecology, Georges Pompidou University Hospital, Paris, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bats
authors.affiliation: Department of Gynecology, Poissy-Saint Germain en Laye University Hospital, Poissy, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Heitz
authors.affiliation: Department of Obstetrics and Gynecology, Edouard Herriot University Hospital, Lyon, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Mathevet
authors.affiliation: Department of Obstetrics and Gynecology, Bretonneau University Hospital, Tours, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Marret
authors.affiliation: Department of Surgical Oncology, Claudius Regaud Comprehensive Cancer Center, Toulouse, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Querleu
authors.affiliation: Department of Obstetrics and Gynecology, Centre Hospitalier Lyon Sud, Lyon, France.
authors.forename: François
authors.initials: F
authors.lastname: Golfier
authors.affiliation: Department of Surgical Oncology, Centre Oscar Lambret, Lille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Leblanc
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France.
authors.forename: Roman
authors.initials: R
authors.lastname: Rouzier
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France. Electronic address: marcos.ballester@tnn.aphp.fr.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ballester
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059186:Chemoradiotherapy, Adjuvant; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*
keywords: Endometrial cancer; Lymphadenectomy; Recurrence free survival; Sentinel lymph node biopsy; Ultrastaging