title: Correlation of (18)F-BPA and (18)F-FDG uptake in head and neck cancers.
abstract: OBJECTIVE
  The aim of this study was to compare the accumulation of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) with that of (18)F-fluorodeoxyglucose ((18)F-FDG) in head and neck cancers, and to assess the usefulness of (18)F-FDG PET for screening candidates for boron neutron capture therapy (BNCT).
  
  
  METHODS
  Twenty patients with pathologically proven malignant tumors of the head and neck were recruited from March 2012 to January 2014. All patients underwent both whole-body (18)F-BPA PET/CT and (18)F-FDG PET/CT within 2weeks of each other. The uptakes of (18)F-BPA and (18)F-FDG at 1h after injection were evaluated using the maximum standardized uptake value (SUVmax).
  
  
  RESULTS
  The accumulation of (18)F-FDG was significantly correlated with that of (18)F-BPA. The SUVmax of (18)F-FDG ⩾5.0 is considered to be suggestive of high (18)F-BPA accumulation.
  
  
  CONCLUSIONS
  (18)F-FDG PET might be an effective screening method performed prior to (18)F-BPA for selecting patients with head and neck cancer for treatment with BNCT.
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan; Department of Radiology, Nippon Medical School, Tokyo, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Tani
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan. Electronic address: hikuriha@ncc.go.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Hiroi
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Natsuki
authors.initials: N
authors.lastname: Honda
authors.affiliation: Division of Functional Imaging, National Cancer Center Hospital East, Chiba, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Yoshimoto
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kono
authors.affiliation: Department of Radiology, Nippon Medical School, Tokyo, Japan.
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Murakami
authors.affiliation: Department of Radiology, Nippon Medical School, Tokyo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
mesh_terms: D000328:Adult; D000368:Aged; D001896:Boron Compounds / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D001896:Boron Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C072915:4-borono-2-fluorophenylalanine; D010649:Phenylalanine
keywords: BNCT; BPA; FDG; Head and neck tumor; PET/CT