title: Nanotextured stainless steel for improved corrosion resistance and biological response in coronary stenting.
abstract: Nanosurface engineering of metallic substrates for improved cellular response is a persistent theme in biomaterials research. The need to improve the long term prognosis of commercially available stents has led us to adopt a 'polymer-free' approach which is cost effective and industrially scalable. In this study, 316L stainless steel substrates were surface modified by hydrothermal treatment in alkaline pH, with and without the addition of a chromium precursor, to generate a well adherent uniform nanotopography. The modified surfaces showed improved hemocompatibility and augmented endothelialization, while hindering the proliferation of smooth muscle cells. Moreover, they also exhibited superior material properties like corrosion resistance, surface integrity and reduced metal ion leaching. The combination of improved corrosion resistance and selective vascular cell viability provided by nanomodification can be successfully utilized to offer a cell-friendly solution to the inherent limitations pertinent to bare metallic stents.
authors.affiliation: Amrita Centre for Nanosciences, Amrita Institute of Medical Science and Research Centre, Amrita Vishwa Vidyapeetham, Cochin 682 041, Kerala, India. deepthymenon@aims.amrita.edu deepsmenon@gmail.com.
authors.forename: Chandini C
authors.initials: CC
authors.lastname: Mohan
authors.forename: Anupama
authors.initials: A
authors.lastname: Prabhath
authors.forename: Aleena Mary
authors.initials: AM
authors.lastname: Cherian
authors.forename: Sajini
authors.initials: S
authors.lastname: Vadukumpully
authors.forename: Shantikumar V
authors.initials: SV
authors.lastname: Nair
authors.forename: Krishnaprasad
authors.initials: K
authors.lastname: Chennazhi
authors.forename: Deepthy
authors.initials: D
authors.lastname: Menon
mesh_terms: D001773:Blood Cells / Q000166:cytology / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002857:Chromium / Q000737:chemistry; D003343:Corrosion; D055119:Elastic Modulus; D006461:Hemolysis / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D049329:Nanostructures / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D013193:Stainless Steel / Q000737:chemistry* / Q000633:toxicity; D015607:Stents; D013499:Surface Properties
chemical_list: D002857:Chromium; D013193:Stainless Steel