title: [Phenylephrine potentiates antidepressive and eliminates sedative action of amitriptyline in rats].
abstract: Single i. m. injection of amitriptyline in rats in high doses of 10-30 mg/kg causes a weak an- tidepressive effect because only in 1.3-1.7 times decrease immobilization in Porsolt test. In the specified doses amitriptyline exhibits appreciable sedative effect because in 3-6 times decrease horizontal activity, and also in 2-2.5 times decrease vertical activity of rats in the open field test. Combined single i.m. injection of amitriptyline in a small dose of 3 mg/kg and high dose of 30 mg/kg with phenylephine in threshold, noneffective alone dose of 0.02 mg/kg, causes the ma- ximal antidepressive effect because decreases immobilization in Porsolt test, accordingly, in 3 and 4.6 times, but does not produce side sedative effect in the open field test. The basis of the mec- hanism of potentiation of antidepressive action and elimination of sedative action of amitriptyline is the stimulation of gastric mucosa afferents by phenylephine.
authors.forename: S E
authors.initials: SE
authors.lastname: Serdiuk
authors.forename: V E
authors.initials: VE
authors.lastname: Gmiro
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D007273:Injections, Intramuscular; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013566:Sympathomimetics / Q000494:pharmacology*; D014851:Wakefulness / Q000502:physiology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013566:Sympathomimetics; D000639:Amitriptyline; D010656:Phenylephrine