title: Bergenia crassifolia (L.) Fritsch--pharmacology and phytochemistry.
abstract: OBJECTIVE
  Bergenia crassifolia (L.) Fritsch, a species in the Bergenia genus belongs to the family Saxifragaceae, is valuated for its medicinal application. The review focuses on the medicinal uses, phytochemistry, and the biological activities of B. crassifolia to explore its benefits and potential uses.
  
  
  METHODS
  In this review, we summarized data, published in Russia and in other countries related to B. crassifolia.
  
  
  RESULTS
  Rhizomes and leaves of this plant are in use as traditional remedies for the treatment of different disorders in the folk medicine systems of Russia and Asia. The plant is a potential source of tannins, benzanoids, flavonoids, polysaccharides and other active compounds. Due to the presence of a multitude of bioactives, a wide array of pharmacological activities have been ascribed to different parts of this herb and individual compounds, which include adaptogenic, antiinflammatory, antihypertensive, antimicrobial, antioxidant, antiobesity, antitussive, cerebro-protective, hepatoprotective, immunomodulating, and diuretic.
  
  
  CONCLUSIONS
  The review highlights the potential of B. crassifolia for further development of herbal medicines on its base.
authors.affiliation: Saint-Petersburg Institute of Pharmacy, Leningrad Region, Vsevolozhsky District, 188663, Kuzmolovo P 245, Russia. Electronic address: spb.pharmacy@gmail.com.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Shikov
authors.affiliation: Saint-Petersburg Institute of Pharmacy, Leningrad Region, Vsevolozhsky District, 188663, Kuzmolovo P 245, Russia.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Pozharitskaya
authors.affiliation: Saint-Petersburg Institute of Pharmacy, Leningrad Region, Vsevolozhsky District, 188663, Kuzmolovo P 245, Russia.
authors.forename: Marina N
authors.initials: MN
authors.lastname: Makarova
authors.affiliation: Saint-Petersburg Institute of Pharmacy, Leningrad Region, Vsevolozhsky District, 188663, Kuzmolovo P 245, Russia.
authors.forename: Valery G
authors.initials: VG
authors.lastname: Makarov
authors.affiliation: Institute of Pharmacy, Pharmaceutical Biology, Ludwig Maximilian University, D-81377 Munich, Germany.
authors.forename: Hildebert
authors.initials: H
authors.lastname: Wagner
mesh_terms: D000818:Animals; D020834:Ethnopharmacology; D006801:Humans; D008519:Medicine, Traditional; D008986:Mongolia; D064209:Phytochemicals / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012426:Russia; D031995:Saxifragaceae / Q000737:chemistry*; D018609:Tibet
chemical_list: D064209:Phytochemicals; D010936:Plant Extracts
keywords: Active compounds; Bergenia crassifolia; Pharmacological effects