title: CNS involvement in pancreatic adenocarcinoma: a report of eight cases from the Johns Hopkins Hospital and review of literature.
abstract: OBJECTIVE
  CNS metastasis of pancreatic cancer is extremely rare, although systemic metastasis is very common. We present eight such cases with various forms of nervous system involvement.
  
  
  METHODS
  Data was gathered from chart review of 800 patients with pancreatic cancer treated between 2004 and 2012 of which eight patients are described with CNS metastases.
  
  
  RESULTS
  The median age of patients was 61.5 years and the median time to develop CNS metastasis was 29 months. Interestingly, two patients had no other sites of metastasis. The treatment modalities tried included resection followed by radiation, resection alone, or whole brain radiation.
authors.affiliation: Department of Hematology/Oncology, University of Arizona Medical Center, 1501, N Campbell Ave, Tucson, AZ, USA, dr.abhijeetkumar@gmail.com.
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Kumar
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Dagar
authors.forename: Joseph
authors.initials: J
authors.lastname: Herman
authors.forename: Christine
authors.initials: C
authors.lastname: Iacobuzio-Donahue
authors.forename: Dan
authors.initials: D
authors.lastname: Laheru
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*