title: Whole-brain radiotherapy in patients with brain metastases from melanoma.
abstract: OBJECTIVE
  To describe results of melanoma brain metastases (BM) treated with whole-brain radiation (WBRT).
  
  
  METHODS
  Retrospective review of patients with melanoma BM treated with WBRT divided into two groups based on the timing of WBRT (at BM diagnosis or recurrence).
  
  
  RESULTS
  We identified 61 patients with melanoma BM who received WBRT. For the group treated at diagnosis (n = 39): median overall survival was 3 months; best radiographic response included one partial response, ten stable disease, 18 progressive disease, and ten no follow-up imaging. For the group treated at recurrence (n = 22): median overall survival was 3 months; best radiographic response was three partial response, four stable disease, eight progressive disease, and seven no follow-up imaging.
  
  
  CONCLUSIONS
  WBRT activity was limited; however, its role in symptom palliation is unclear.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Macarena
authors.initials: M
authors.lastname: de la Fuente
authors.forename: Kathryn
authors.initials: K
authors.lastname: Beal
authors.forename: Richard
authors.initials: R
authors.lastname: Carvajal
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kaley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D016371:Cranial Irradiation / Q000379:methods*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: WBRT; brain metastases; ipilimumab; melanoma; overall survival; radiographic response