title: Local application of Aqua Titan improves symptoms of temporomandibular joint muscle disorder: a preliminary study.
abstract: Aqua Titan (AT), comprising microscopic titanium particles dispersed in water, has been reported to have beneficial effects on muscle tissue. This study investigated the effects of local application of AT on symptoms in patients with muscle disorders of the temporomandibular joint (TMJ) compared to patients with joint disorders of the TMJ. Sixteen patients with unilateral masseter muscle pain during motion (muscle disorder group) and six patients with unilateral TMJ pain during motion (joint disorder group) applied an AT-permeated patch over the painful area every night for 2 weeks. Symptoms were evaluated clinically at the initial visit and 1 and 2 weeks later. Clinical symptoms in the joint disorder group showed no tendency towards improvement after 2 weeks. In contrast, mouth opening range with/without pain, visual analogue scale (VAS) scores for pain during mouth opening and eating, and activities of daily living (ADL) scores in the muscle disorder group were improved significantly after 2 weeks. Multiple comparison tests in the muscle disorder group showed significant improvements in the VAS for eating and ADL score after 1 week. These results suggest that the AT patch has a potential supplementary role in the treatment of patients with muscle disorders of the TMJ.
authors.affiliation: Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan; Department of Temporomandibular Disorders, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan. Electronic address: matsumoto.kunihito@nihon-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Temporomandibular Disorders, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan; Department of Partial Denture Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsukimura
authors.affiliation: Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan; Department of Temporomandibular Disorders, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishizuka
authors.affiliation: Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kohinata
authors.affiliation: Department of Temporomandibular Disorders, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yonehara
authors.affiliation: Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan; Department of Temporomandibular Disorders, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Honda
mesh_terms: D000203:Activities of Daily Living; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008406:Masseter Muscle; D008875:Middle Aged; D059408:Pain Management; D010147:Pain Measurement; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy*; D014025:Titanium / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D014025:Titanium
keywords: Aqua Titan; masseter muscle; muscle pain; temporomandibular disorder