title: Semi-automatic motion compensation of contrast-enhanced ultrasound images from abdominal organs for perfusion analysis.
abstract: This paper presents a system for correcting motion influences in time-dependent 2D contrast-enhanced ultrasound (CEUS) images to assess tissue perfusion characteristics. The system consists of a semi-automatic frame selection method to find images with out-of-plane motion as well as a method for automatic motion compensation. Translational and non-rigid motion compensation is applied by introducing a temporal continuity assumption. A study consisting of 40 clinical datasets was conducted to compare the perfusion with simulated perfusion using pharmacokinetic modeling. Overall, the proposed approach decreased the mean average difference between the measured perfusion and the pharmacokinetic model estimation. It was non-inferior for three out of four patient cohorts to a manual approach and reduced the analysis time by 41% compared to manual processing.
authors.affiliation: Department of Simulation and Graphics, University of Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany. Electronic address: sebastian.schaefer@ovgu.de.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schäfer
authors.affiliation: National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Kim
authors.initials: K
authors.lastname: Nylund
authors.affiliation: Department of Clinical Medicine, University of Bergen, Norway; National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Sævik
authors.affiliation: Section of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway; National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Trond
authors.initials: T
authors.lastname: Engjom
authors.affiliation: Department of Biomedical Engineering, Brno University of Technology, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Mézl
authors.affiliation: Institute of Scientific Instruments of the Academy of Sciences of the Czech Republic, Brno, Czech Republic; International Clinical Research Center - Center of Biomedical Engineering, St. Anne׳s University Hospital Brno, Czech Republic.
authors.forename: Radovan
authors.initials: R
authors.lastname: Jiřík
authors.affiliation: Section of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway; National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Georg
authors.initials: G
authors.lastname: Dimcevski
authors.affiliation: National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Norway.
authors.forename: Odd Helge
authors.initials: OH
authors.lastname: Gilja
authors.affiliation: Department of Simulation and Graphics, University of Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Tönnies
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D009038:Motion; D014463:Ultrasonography
chemical_list: D003287:Contrast Media
keywords: CEUS; Contrast-enhanced ultrasound; Motion analysis; Motion compensation; Perfusion; Perfusion modeling; Registration; Ultrasonography