title: Omics and biotechnology of arsenic stress and detoxification in plants: current updates and prospective.
abstract: Arsenic (As), a naturally occurring metallic element, is a dreadful health hazard to millions of people across the globe. Arsenic is present in low amount in the environment and originates from anthropogenic impact and geogenic sources. The presence of As in groundwater used for irrigation is a worldwide problem as it affects crop productivity, accumulates to different tissues and contaminates food chain. The consumption of As contaminated water or food products leads to several diseases and even death. Recently, studies have been carried out to explore the biochemical and molecular mechanisms which contribute to As toxicity, accumulation, detoxification and tolerance acquisition in plants. This information has led to the development of the biotechnological tools for developing plants with modulated As tolerance and detoxification to safeguard cellular and genetic integrity as well as to minimize food chain contamination. This review aims to provide current updates about the biochemical and molecular networks involved in As uptake by plants and the recent developments in the area of functional genomics in terms of developing As tolerant and low As accumulating plants.
authors.affiliation: CSIR-National Botanical Research Institute (CSIR-NBRI), Rana Pratap Marg, Lucknow 226001, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Rama Shanker
authors.initials: RS
authors.lastname: Dubey
authors.affiliation: CSIR-National Botanical Research Institute (CSIR-NBRI), Rana Pratap Marg, Lucknow 226001, India.
authors.forename: Rudra Deo
authors.initials: RD
authors.lastname: Tripathi
authors.affiliation: CSIR-National Botanical Research Institute (CSIR-NBRI), Rana Pratap Marg, Lucknow 226001, India.
authors.forename: Debasis
authors.initials: D
authors.lastname: Chakrabarty
authors.affiliation: CSIR-National Botanical Research Institute (CSIR-NBRI), Rana Pratap Marg, Lucknow 226001, India. Electronic address: prabodht@hotmail.com.
authors.forename: Prabodh Kumar
authors.initials: PK
authors.lastname: Trivedi
mesh_terms: D001151:Arsenic / Q000493:pharmacokinetics* / Q000633:toxicity; D001709:Biotechnology; D004785:Environmental Pollutants / Q000493:pharmacokinetics*; D020387:Food Chain; D005506:Food Contamination; D023281:Genomics; D055442:Metabolome; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000378:metabolism; D020543:Proteome / Q000378:metabolism; D013312:Stress, Physiological / Q000235:genetics; D059467:Transcriptome
chemical_list: D004785:Environmental Pollutants; D020543:Proteome; D001151:Arsenic
keywords: Arsenic; Metabolomic; Proteomic; Rice; Transcriptomic; Transgenic plants