title: [Effects of high-fat diet on FABP2 mRNA expression in small intestinal tissue of young rats].
abstract: OBJECTIVE
  To measured FABP2 mRNA expression of small intestinal rats in response to high-fat diet; and to explore the correlation between expression and child obesity in rats.
  
  
  METHODS
  The young obese rat models high-fat diet-induced method. Then the expression levels of FABP2 mRNA jejunum and ileum tissues of young rats were detected and analyzed using real time fluorescence quantitative PCR method. The serum biochemical assessed with an automatic biochemical Analyzer.
  
  
  RESULTS
  In both rnd obesity group, the expression levels of FABP2 mRNA were highest in ermediate in the jejunum, and lowest in the duodenum both the control obesity group, there' were significant differences among them ( P <0. 05). Compated with control group, the expression levels of FABP2 mRNA in obesity group were significantly decreased (P <0.05); and the levels of blood glucose and serum TG in the obesity group were significantly higher (P < 0.05 ).
  
  
  CONCLUSIONS
  FABP2 mRNA expression was different in diverse segments of intestinal tissue. Feeding high-fat diets allowed rats to reduce the expression levels of FABP2 mRNA in small intestinal tissue, meanwhile, the rats gained weight and elevate serum TG levels. It suggests that FABP2 involves in lipid metabolism, and is associated with the development of childhood obesity.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Xu
authors.forename: Wendong
authors.initials: W
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Hao
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Chang
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D059305:Diet, High-Fat; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D050356:Lipid Metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; C493407:Fabp2 protein, rat; D050556:Fatty Acid-Binding Proteins; D012333:RNA, Messenger