title: [The influence of selective serotonin re-uptake inhibitor fluoxetine on inotropic function of myocardium in the ontogenesis of rats].
abstract: Mechanisms of action of selective serotonin (5-HT) re-uptake inhibitors (SSRIs) on cardiac function in the ontogenetic aspect are not adequately explored. Object--Wistar rats: mature rats, pregnant females and their offspring at the age of 14 days. The positive inotropic reaction was detected to SSRIs fluoxetine (Flu) (0.1, 1.0, 10.0 μM) of the ventricles of adult rats, trittiko (SSRIs) exposed 14-day-old rats during the embryonic period. This is showed that contraction force was increased, the overall time contraction was decreased heavily due to more rapid relaxation. The effect on Flu is saved on the background of 5-HT (1.0 μM). The positive inotropic effect of 5-HT was decreased after the addition of all concentration of Flu. However, a dose-dependent increase of ventricle contraction force was revealed on Flu in mature rats. The positive inotropic effect of Flu, Flu on the back of trittiko in the left ventricle is higher than in the right; on the back of 5-HT is more pronounced in the right ventricle than in the left. The positive inotropic effect is decreased in the ventricles of 14-day-old when the concentration of Flu is increased.
authors.forename: R R
authors.initials: RR
authors.lastname: Nigmatullina
authors.forename: V L
authors.initials: VL
authors.lastname: Matveeva
authors.forename: M D
authors.initials: MD
authors.lastname: Chibireva
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D006352:Heart Ventricles / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D014196:Trazodone / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D005473:Fluoxetine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone