title: Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing.
abstract: This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project "Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics" (Predict-IV; Grant 202222). The project's overall aim was to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silico modeling, in a rapid and cost effective manner. This overview introduces the scope and overall achievements of Predict-IV.
authors.affiliation: Nonclinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany; Institute of Applied Biosciences, Toxicology, Karlsruhe Institute of Technology, Karlsruhe, Germany. Electronic address: Stefan.o.mueller@t-online.de.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Mueller
authors.affiliation: Department of Toxicology, University of Würzburg, Würzburg 97078, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dekant
authors.affiliation: Division of Physiology, Dept. of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck 6020, Austria.
authors.forename: Paul
authors.initials: P
authors.lastname: Jennings
authors.affiliation: Environment and Primary Prevention Department, Istituto di Superiore di Sanitá, Rome 00161, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Testai
authors.affiliation: INERIS, DRC/VIVA/METO, Verneuil-en-Halatte, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Bois
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D055808:Drug Discovery; D064420:Drug-Related Side Effects and Adverse Reactions; D005062:European Union; D006801:Humans; D008954:Models, Biological; D019055:No-Observed-Adverse-Effect Level; D004364:Pharmaceutical Preparations / Q000592:standards*; D049490:Systems Biology / Q000379:methods*; D018675:Toxicity Tests; D014116:Toxicology / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Cellular models; Central nervous system (CNS); Kidney; Liver; Predict-IV; Systems toxicology