title: Interaction between paraoxonase 1 polymorphism and prenatal pesticide exposure on metabolic markers in children using a multiplex approach.
abstract: Prenatal environmental exposures may influence the risk of cardio-metabolic diseases later in life. This study used a multiplex approach to investigate non-fasting serum levels of metabolic markers in a cohort of school-aged children for whom associations between prenatal pesticide exposure and body fat content and blood pressure were previously found to be dependent on paraoxonase1 (PON1) Q192R genotype. In children with the PON1 192 R-allele, leptin, glucagon, and plasminogen activator inhibitor-1 (PAI-1) were positively associated with prenatal pesticide exposure. For PON1 192 QQ-homozygote children none of the biomarkers were significantly affected by prenatal pesticide exposure. In children with the R-allele, leptin was associated with both body fat measures and prenatal pesticide exposure and seems to mediate body fat accumulation in exposed children. These findings support our previous results of an adverse cardio-metabolic risk profile associated with prenatal pesticide exposure in children with the PON1 192 R-allele.
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark; University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Jørgensen
authors.affiliation: National Food Institute, Division of Toxicology and Risk Assessment, Technical University of Denmark, Søborg, Denmark.
authors.forename: Christine
authors.initials: C
authors.lastname: Nellemann
authors.affiliation: University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Christine
authors.initials: C
authors.lastname: Wohlfahrt-Veje
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Tina Kold
authors.initials: TK
authors.lastname: Jensen
authors.affiliation: University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Katharina M
authors.initials: KM
authors.lastname: Main
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address: hrandersen@health.sdu.dk.
authors.forename: Helle Raun
authors.initials: HR
authors.lastname: Andersen
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000453:epidemiology*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D007328:Insulin; D020738:Leptin; D010575:Pesticides; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D005934:Glucagon; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Environmental obesogens; Glucagon; Leptin; PAI-1; Pesticides, Prenatal exposure, PON1 genotype