title: A model of mandibular irradiation in the rabbit: preliminary results.
abstract: Radiotherapy is widely used in the treatment of head and neck cancers. Its major adverse effect is osteoradionecrosis, which can occur during the whole life of the patient, involving the vital prognosis. The aim of the study was to develop a model for irradiation of the rabbit mandible in order to have a better knowledge of radiotherapy-induced bone alterations and thus a better prevention and treatment of osteoradionecrosis. The control group consisted in 7 rabbits and was used to assess anatomical and histological parameters of the rabbit's mandible. A first group of 14 rabbits was weekly irradiated at doses of 5.5 Gy during 5 weeks, at a total dose of 46.8Gy. Sacrifices were done at 1 week, 4 weeks, 12 weeks and 24 weeks. As histological analysis did not reveal statistical differences with the control group, a second group (3 rabbits) was weekly irradiated at 8.0, 8.5 and 9 Gy during 5 weeks. The first histological results seem to show vascular alterations, bone cells decrease and alterations of bone architecture. The role of intra alveolar collagen sponges, PRF®, ultrasounds and stem cells in bone regeneration after radiotherapy will be further studied.
authors.affiliation: Institut de Chirurgie Expérimentale, Centre Régional de Lutte Contre le Cancer, Lyon, France. anne-gaelle.bodard@lyon.unicancer.fr.
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Bodard
authors.affiliation: Institut de Chirurgie Expérimentale, Centre Régional de Lutte Contre le Cancer, Lyon, France.
authors.forename: Soufyane
authors.initials: S
authors.lastname: Debbache
authors.affiliation: Institut de Chirurgie Expérimentale, Centre Régional de Lutte Contre le Cancer, Lyon, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Langonnet
authors.affiliation: Centre Léon Bérard, Lyon , France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laffay
authors.affiliation: Centre Léon Bérard, Lyon , France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Fleury
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects; D015519:Bone Density / Q000528:radiation effects; D016723:Bone Remodeling / Q000528:radiation effects; D004195:Disease Models, Animal; D005260:Female; D008334:Mandible / Q000098:blood supply / Q000473:pathology / Q000528:radiation effects*; D008336:Mandibular Diseases / Q000209:etiology* / Q000473:pathology; D010006:Osteoblasts / Q000528:radiation effects; D010010:Osteoclasts / Q000528:radiation effects; D010011:Osteocytes / Q000528:radiation effects; D010025:Osteoradionecrosis / Q000209:etiology* / Q000473:pathology; D011817:Rabbits; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013997:Time Factors