title: Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease.
abstract: OBJECTIVE
  We conducted a retrospective study to evaluate the role of prophylactic cranial irradiation (PCI) on patients with surgically resected small cell lung cancer (SCLC).
  
  
  METHODS
  Between January 2003 and December 2009, the records of completely resected patients who were diagnosed with SCLC and definitive pTNM stage on the basis of histological proof were reviewed. According to the therapy modality, patients were allocated to PCI group and non-PCI group.
  
  
  RESULTS
  A total of 193 patients were finally included, 67 patients in PCI group and 126 in non-PCI group. The OS rates at 2-year and 5-year in PCI group were 92.5%, and 54.9%, respectively, and those of non-PCI were 63.2% and 47.8%, respectively (p=0.005). The BMFS rate at 2-year and 5-year in PCI group was significantly better than those of non-PCI group (96.8%, 76.6% and 79.4%, 75.5%, respectively, p = 0.014). But PCI could not confer survival benefit in the patients with p-stage I. Multivariate analysis revealed that PCI (HR = 2.339; p = 0.001) was an independent prognostic factor of the overall survival.
  
  
  CONCLUSIONS
  PCI could improve the OS of patients with surgically resected SCLC, but not for p-stage I patients.
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute; Shan Dong Univesity, Jinan, Shandong Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute; Shan Dong Univesity, Jinan, Shandong Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute; Shan Dong Univesity, Jinan, Shandong Province, China; Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Kunli
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Xibin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute; Shan Dong Univesity, Jinan, Shandong Province, China. Electronic address: kongli7@sina.com.
authors.forename: Li
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute; Shan Dong Univesity, Jinan, Shandong Province, China. Electronic address: sdyujinming@163.com.
authors.forename: Jingming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate
keywords: Overall survival; PCI; Prognosis; Small cell lung cancer; Surgical resection; Survival