title: Hazard assessment of fluorinated alternatives to long-chain perfluoroalkyl acids (PFAAs) and their precursors: status quo, ongoing challenges and possible solutions.
abstract: Because of concerns over the impact of long-chain perfluoroalkyl acids (PFAAs) on humans and the environment, PFAAs and their precursors are being substituted by alternative substances including fluorinated alternatives that are structurally similar to the substances they replace. Using publicly accessible information, we aimed to identify the status quo of the hazard assessment of identified fluorinated alternatives, to analyze possible systemic shortcomings of the current industrial transition to alternative substances, and to outline possible solutions. Fluorinated alternatives, particularly short-chain PFAAs and perfluoroether carboxylic and sulfonic acids (PFECAs and PFESAs), possess high environmental stability and mobility implying that they have a high global contamination potential. In addition to their potential for causing global exposures, certain fluorinated alternatives have been identified as toxic and are thus likely to pose global risks to humans and the environment. Various factors, particularly the information asymmetry between industry and other stakeholders, have contributed to the current lack of knowledge about the risks posed by fluorinated alternatives. Available cases show that a non-fluorinated substitution strategy (employing either chemical or functionality substitutions) can be a possible long-term, sustainable solution and needs to be further developed and assessed.
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland. Electronic address: zhanyun.wang@chem.ethz.ch.
authors.forename: Zhanyun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Applied Environmental Science (ITM), Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Ian T
authors.initials: IT
authors.lastname: Cousins
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland; Institute of Sustainable and Environmental Chemistry, Leuphana University Lüneburg, D-21335 Lüneburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Scheringer
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Hungerbuehler
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000633:toxicity; D004777:Environment; D004785:Environmental Pollutants / Q000633:toxicity*; D004987:Ethers / Q000633:toxicity; D005466:Fluorocarbons / Q000633:toxicity*; D006801:Humans; D018570:Risk Assessment; D013451:Sulfonic Acids / Q000633:toxicity
chemical_list: D002264:Carboxylic Acids; D004785:Environmental Pollutants; D004987:Ethers; D005466:Fluorocarbons; D013451:Sulfonic Acids
keywords: Data gaps; Global contamination; PBT assessment; Perfluoroether carboxylic acids; Perfluoroether sulfonic acids; Short-chain perfluoroalkyl acids