title: Polymorphisms in the fibrinolytic pathway genes and the risk of recurrent spontaneous abortion.
abstract: Impaired fibrinolytic activity is implicated in the pathogenesis of recurrent spontaneous abortion (RSA). This case-control study assessed the prevalence of polymorphisms in fibrinolytic system genes in RSA. Cases comprised 202 Sinhalese women who had experienced at least two first-trimester spontaneous abortions and had no living children; controls were 202 women with no history of spontaneous abortion and two or more living children. The groups were matched for age and ethnicity. DNA was genotyped using the Sequenom MassARRAY system. The PLAUR rs4251923 A (OR 95% CI 2.3 [1.3 to 4.0]), SERBP2 rs6098 A (OR 95% CI 1.4 [1.1 to 1.9]) and SERBP2 rs6103 C alleles (OR 95% CI 1.4 [1.1 to 1.9]) were increased in the RSA group compared with controls. The prevalence of PLAUR rs4251923/ SERBP2 rs6098/ SERBP2 rs6103 GG/AA/CC (OR 95% CI 2.4 [1.2 to 4.9], GA/GA/GC(OR 95% CI 3.9 [1.3 to 11.2]), GA/AA/CC (OR 95% CI 2.9 [1.0 to 8.6] and GA/GG/GG (OR 95% CI 21.3 [1.1 to 410.3]) genotypes were also increased in cases. Polymorphisms in the fibrinolytic system genes are associated with RSA in Sinhalese women. These likely impair implantation.
authors.affiliation: School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia; Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Electronic address: prabha.andraweera@adelaide.edu.au.
authors.forename: Prabha H
authors.initials: PH
authors.lastname: Andraweera
authors.affiliation: School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia; Women's and Children's Division, Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia.
authors.forename: Gustaaf A
authors.initials: GA
authors.lastname: Dekker
authors.affiliation: School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Thompson
authors.affiliation: School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia.
authors.forename: Rachael C
authors.initials: RC
authors.lastname: Nowak
authors.affiliation: Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
authors.forename: Rohan W
authors.initials: RW
authors.lastname: Jayasekara
authors.affiliation: Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
authors.forename: Vajira H W
authors.initials: VH
authors.lastname: Dissanayake
authors.affiliation: School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D010064:Embryo Implantation / Q000235:genetics*; D005260:Female; D005342:Fibrinolysis / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D017396:Plasminogen Activator Inhibitor 2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D055293:Receptors, Urokinase Plasminogen Activator / Q000235:genetics*; D013188:Sri Lanka
chemical_list: D017931:DNA Primers; C524898:PLAUR protein, human; D017396:Plasminogen Activator Inhibitor 2; D055293:Receptors, Urokinase Plasminogen Activator
keywords: fibrinolytic pathway; gene; miscarriage; polymorphism; pregnancy