title: The impact of clinical prognostic factors on the survival of patients with oral squamous cell carcinoma.
abstract: OBJECTIVE
  This study investigated prognostic factors and useful predictors for survival in patients with oral squamous cell carcinoma.
  
  
  METHODS
  The medical records of all patients with oral squamous cell carcinoma who underwent curative surgery with or without adjuvant radiation from 2009 through 2011 were retrospectively reviewed.
  
  
  RESULTS
  Seventy-seven patients (63 men and 14 women) were enrolled. The 2-year disease-free and overall survival rates were 67.5% and 74%, respectively. Multivariate analyses showed that a diagnostic delay longer than 2 months (hazard ratio [HR]=4.43; 95% confidence interval [CI], 1.26-15.51; P=.02), T3 or T4 tumor (HR=4.40; 95% CI, 1.91-10.12; P=.001), neck metastasis (HR=1.96; 95% CI, 1.21-4.37; P=.01), and stage III or IV disease (HR=3.94; 95% CI, 1.64-9.47; P=.002) were independent adverse factors for survival rate.
  
  
  CONCLUSIONS
  Oral squamous cell carcinoma is an important health issue associated with poor survival. A diagnostic delay longer than 2 months, T3 or T4 tumor, neck metastasis, and stage III or IV disease were independent adverse factors for subsequent survival rate and locoregional recurrence in patients with oral squamous cell carcinoma.
authors.affiliation: Attending Staff, Department of Oral and Maxillofacial Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: 597318966@qq.com.
authors.forename: Xiang-Juan
authors.initials: XJ
authors.lastname: Tong
authors.affiliation: Assistant Professor, Department of Head and Neck Surgery, Hunan Provincial Tumor Hospital, Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, China.
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Shan
authors.affiliation: Professor and Director, Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Zhan-Gui
authors.initials: ZG
authors.lastname: Tang
authors.affiliation: Associate Professor and Director, Department of Oral and Maxillofacial Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xin-Cheng
authors.initials: XC
authors.lastname: Guo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000503:physiopathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate