title: Different sensitization to storage mites depending on the co-exposure to house dust mites.
abstract: BACKGROUND
  Co-sensitization to house dust mites (HDMs) and storage mites (SMs) is very frequent, although the clinical relevance is not well established.
  
  
  OBJECTIVE
  To describe the pattern of sensitization and immunologic characterization of patients with positive skin prick test reactions to HDMs and SMs in 4 areas of Spain, selected according to high exposure to HDMs and variable exposure to SMs.
  
  
  METHODS
  One hundred sixty-nine individuals with positive skin prick test reactions to HDMs and SMs were included. Specific IgE levels to different mite species and to Der p 1, Der p 2, and Der p 10 were determined. Immunoblots to Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae extracts were carried out, and allergograms were obtained. Results of different areas were compared.
  
  
  RESULTS
  A high rate of polysensitization to SMs was observed, although 12% of participants did not have specific IgE to any SM species. Sensitization to Dermatophagoides species, Der p 2, and L destructor were predominant, although significant differences were observed among areas depending on the grade of exposure to SMs. In areas with high exposure, the SM allergogram showed greater recognition of group 2 allergen.
  
  
  CONCLUSIONS
  Sensitization patterns to SMs in patients sensitized to HDMs and SMs differ depending on the exposure to SMs. Sensitization, mainly to L destructor, seems to exist in areas with high exposure, possibly with group 2 allergens mainly involved. However, in areas with low SM populations, sensitizations observed by skin prick testing appear to be related to HDM exposure.
authors.affiliation: R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Morales
authors.affiliation: R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Iraola
authors.affiliation: R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Leonor
authors.affiliation: Allergy Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Bartra
authors.affiliation: Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez
authors.affiliation: Allergy Section, Hospital Lucus Augusti, Lugo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Boquete
authors.affiliation: Allergy Section, Hospital Santa María del Rosell, Cartagena, Murcia, Spain.
authors.forename: Ángel Julio
authors.initials: ÁJ
authors.lastname: Huertas
authors.affiliation: Fundació Sant Pere Claver, Barcelona, Spain.
authors.forename: María Josefa
authors.initials: MJ
authors.lastname: Paniagua
authors.affiliation: R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain.
authors.forename: Helder
authors.initials: H
authors.lastname: Pinto
authors.affiliation: R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain. Electronic address: jcarnes@leti.com.
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Carnés
mesh_terms: D040041:Acaridae / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D002980:Climate; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D039981:Pyroglyphidae / Q000276:immunology*; D012882:Skin Tests; D013030:Spain; D055815:Young Adult
chemical_list: D039741:Antigens, Dermatophagoides; D007073:Immunoglobulin E