title: A review of sucroferric oxyhydroxide for the treatment of hyperphosphatemia in patients receiving dialysis.
abstract: OBJECTIVE
  Sucroferric oxyhydroxide is the newest phosphate binder to receive US Food and Drug Administration approval for patients on dialysis. The purpose of this review is to critically evaluate the studies that have been conducted with this medication and determine where it may fit in the clinician's overall treatment plan for hyperphosphatemia in patients with chronic kidney disease.
  
  
  METHODS
  Literature searches were performed in the PubMed database and www.ClinicalTrials.gov using the search terms sucroferric oxyhydroxide, and PA21 phosphate binder. Limits were set to include only clinical trials performed in human subjects.
  
  
  RESULTS
  Four completed clinical trials and 3 ongoing studies were identified. Completed clinical trials included Phase I, Phase II, and Phase III studies that all demonstrated the ability of sucroferric oxyhydroxide to lower serum phosphorus concentrations. One study compared sucroferric oxyhydroxide with sevelamer and reported no statistically significant difference in serum phosphorus-lowering ability. The ongoing trials are evaluating sucroferric oxyhydroxide for long term use, in peritoneal dialysis patients, and compared with calcium-based phosphate binders.
  
  
  CONCLUSIONS
  Sucroferric oxyhydroxide is an effective phosphate binder for chronic kidney disease patients receiving hemodialysis and may offer an advantage in terms of pill burden. Gastrointestinal side effects are similar to those of current phosphate binders. Advantages of other phosphate binders (ie, the lipid- and uric acid-lowering abilities of sevelamer) may outweigh the pill burden benefits of sucroferric oxyhydroxide.
authors.affiliation: Purdue University College of Pharmacy, West Lafayette, Indiana.
authors.forename: Ava
authors.initials: A
authors.lastname: Bousher
authors.affiliation: Indiana University Health Arnett Nephrology, Lafayette, Indiana.
authors.forename: Akram
authors.initials: A
authors.lastname: Al-Makki
authors.affiliation: Indiana University Health Arnett Nephrology, Lafayette, Indiana.
authors.forename: James
authors.initials: J
authors.lastname: Sutton
authors.affiliation: Purdue University College of Pharmacy, West Lafayette, Indiana. Electronic address: sheplerb@purdue.edu.
authors.forename: Brian
authors.initials: B
authors.lastname: Shepler
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005290:Ferric Compounds / Q000627:therapeutic use*; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D013395:Sucrose / Q000627:therapeutic use*; D014481:United States
chemical_list: D002614:Chelating Agents; D004338:Drug Combinations; D005290:Ferric Compounds; C000599459:sucroferric oxyhydroxide; D013395:Sucrose
keywords: PA 21; Velphoro; sucroferric oxyhydroxide