title: Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice.
abstract: The anti-inflammatory and analgesic effects of the ethanolic extract (SLEE) and fruticulin A from the leaves of Salvia lachnostachys were evaluated in mice, using experimental models of inflammation (paw oedema and pleurisy induced by carrageenan injection) and hyperalgesia (electronic Von Frey). Oral administration of SLEE (30, 100, and 300 mg/kg) and fruticulin A (0.3 and 3.0 mg/kg) decreased the total leucocytes number in pleural lavage, protein extravasation, and paw oedema. SLEE (100 mg/kg) and fruticulin A (3 mg/kg) also exhibited antihyperalgesic activity in carrageenan induced mechanical hyperalgesia. In addition, fruticulin A (3 mg/kg) prevented mechanical hyperalgesia, inhibiting TNF but not L-DOPA-induced mechanical hyperalgesia. In conclusion, SLEE and fruticulin A display anti-inflammatory and analgesic properties. Therefore, fruticulin A is at least partially responsible for the activity observed in the ethanolic extract of Salvia lachnostachys.
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados (UFGD), Rodovia Dourados, Itahum, Km 12, Cidade Universitária, Caixa Postal 533, 79.804-970 Dourados, MS, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Piccinelli
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados (UFGD), Rodovia Dourados, Itahum, Km 12, Cidade Universitária, Caixa Postal 533, 79.804-970 Dourados, MS, Brazil.
authors.forename: Diana
authors.initials: D
authors.lastname: Figueiredo de Santana Aquino
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados (UFGD), Rodovia Dourados, Itahum, Km 12, Cidade Universitária, Caixa Postal 533, 79.804-970 Dourados, MS, Brazil.
authors.forename: Priscila Neder
authors.initials: PN
authors.lastname: Morato
authors.affiliation: School of Biological and Health Sciences, University Center of Grande Dourados, 79.824-900 Dourados, MS, Brazil.
authors.forename: Angela Midori
authors.initials: AM
authors.lastname: Kuraoka-Oliveira
authors.affiliation: Chemistry Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil.
authors.forename: Regiane Lauriano Batista
authors.initials: RL
authors.lastname: Strapasson
authors.affiliation: Botany Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil.
authors.forename: Elide Pereira
authors.initials: EP
authors.lastname: Dos Santos
authors.affiliation: Chemistry Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil.
authors.forename: Maria Élida Alves
authors.initials: MÉ
authors.lastname: Stefanello
authors.affiliation: "Dr. Hélio Mandetta" School of Medicine, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.
authors.forename: Rodrigo Juliano
authors.initials: RJ
authors.lastname: Oliveira
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados (UFGD), Rodovia Dourados, Itahum, Km 12, Cidade Universitária, Caixa Postal 533, 79.804-970 Dourados, MS, Brazil.
authors.forename: Cândida Aparecida Leite
authors.initials: CA
authors.lastname: Kassuya