title: Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions.
abstract: The effect of hypoxic conditions on the in vitro efficacy of amphotericin B and posaconazole against Mucorales was evaluated by defining MICs with Etest and broth microdilution and identifying minimal fungicidal concentrations (MFCs). With Etest, oxygen-dependent changes were detected, while the MIC and the MFC determined with broth microdilution remained unaltered with reduced oxygen levels. The observed differences depended on the method used.
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Maurer
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria ulrike.binder@i-med.ac.at.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Binder
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Manuela
authors.initials: M
authors.lastname: Sparber
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Lackner
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Rita
authors.initials: R
authors.lastname: Caramalho
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D015687:Cell Hypoxia / Q000502:physiology; D008826:Microbial Sensitivity Tests; D009090:Mucorales / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B