title: Human granzymes: related but far apart.
abstract: Granzymes (GZMs) are a class of serine protease, found in cytoplasmic granules of cytotoxic T cells and natural killer cells. The main function of these proteins has been recognized as wiping out viral infections via inducing the apoptosis. This review will highlight inter and intra species differences of GZMs in terms of their functional and structure. These futures may help to device a strategy for isolation of human specific GZMs, which are needed for understating of their role in immune system and devising an effective immune therapy.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Ontario, Canada; Razi Vaccine & Serum Research Institute, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Vahedi
authors.affiliation: Health Sciences North, Sudbury, Ontario K2J 5H4, Canada.
authors.forename: Nya
authors.initials: N
authors.lastname: Fraleigh
authors.affiliation: Health Sciences North, Sudbury, Ontario K2J 5H4, Canada.
authors.forename: Caitlyn
authors.initials: C
authors.lastname: Vlasschaert
authors.affiliation: Health Sciences North, Sudbury, Ontario K2J 5H4, Canada; Medical & Human Sciences Division, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: McElhaney
authors.affiliation: Medical & Human Sciences Division, Northern Ontario School of Medicine, Sudbury, Ontario, Canada; Department of Biology and Biomolecular Sciences Program - Laurentian University, Sudbury, Ontario, Canada. Electronic address: phanifimoghaddam@laurentian.ca.
authors.forename: Pejman
authors.initials: P
authors.lastname: Hanifi-Moghaddam
mesh_terms: D000818:Animals; D017209:Apoptosis; D020134:Catalytic Domain; D003593:Cytoplasm / Q000378:metabolism; D005089:Exocytosis; D023281:Genomics; D053804:Granzymes / Q000502:physiology*; D006801:Humans; D007107:Immune System; D007694:Killer Cells, Natural / Q000201:enzymology / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D017433:Protein Structure, Secondary; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology
chemical_list: D053804:Granzymes