title: [Advances in the treatment of secondary osteoporosis].
abstract: Osteoporosis is being increasingly recognised in paediatric practice as a consequence of the increasing life expectancy of children who suffer from chronic diseases and other factors. There are many non-pharmacological measures that can improve children' bone health, for example, avoiding inflammatory activity and osteotoxic treatments; increasing sun exposure and weight-bearing exercise, and maintaining an adequate nutritional status. Vitamin D and calcium supplements have been proposed as a measure to increase bone mass, but their effect and therapeutic indications are not completely clear. On the other hand, bisphosphonates are currently the only pharmacological alternative for the patients with infantile secondary osteoporosis. However, more studies are required on the therapeutic indications, posology, and long term secondary effects of biphosphonates. The aim of this article is to analyze the scientific evidence of the effectiveness of the therapeutic alternatives for childhood secondary osteoporosis and their safety in children.
authors.affiliation: Sección de Reumatología Infantil, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario de Málaga, Málaga, España. Electronic address: rociogalin@hotmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Galindo Zavala
authors.affiliation: Sección de Reumatología Infantil, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.
authors.forename: E
authors.initials: E
authors.lastname: Núñez Cuadros
authors.affiliation: Sección de Reumatología Infantil, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.
authors.forename: G
authors.initials: G
authors.lastname: Díaz Cordovés-Rego
authors.affiliation: Sección de Reumatología Infantil, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.
authors.forename: A L
authors.initials: AL
authors.lastname: Urda Cardona
mesh_terms: D000328:Adult; D002648:Child; D019587:Dietary Supplements; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000209:etiology / Q000628:therapy*
chemical_list: D004164:Diphosphonates
keywords: Bifosfonatos; Bisphosphonates; Calcio; Calcium; Children; Niños; Osteoporosis; Vitamin D; Vitamina D