title: Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics simulation.
abstract: Clinical trials have shown that functional assessment of coronary stenosis by fractional flow reserve (FFR) improves clinical outcomes. Intravascular ultrasound (IVUS) complements conventional angiography, and is a powerful tool to assess atherosclerotic plaques and to guide percutaneous coronary intervention (PCI). Computational fluid dynamics (CFD) simulation represents a novel method for the functional assessment of coronary flow. A CFD simulation can be calculated from the data normally acquired by IVUS images. A case of coronary heart disease studied with FFR and IVUS, before and after PCI, is presented. A three-dimensional model was constructed based on IVUS images, to which CFD was applied. A discussion of the literature concerning the clinical utility of CFD simulation is provided.
authors.affiliation: Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain. Electronic address: sebastian_carrizo@live.com.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Carrizo
authors.affiliation: Medical Ultrasound Lab, Department of Electronic Engineering, Fudan University, Shanghai, China.
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Xie
authors.affiliation: Electrophysiology and Arrhythmia Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Peinado-Peinado
authors.affiliation: Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Sánchez-Recalde
authors.affiliation: Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Jiménez-Valero
authors.affiliation: Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Galeote-Garcia
authors.affiliation: Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Moreno
mesh_terms: D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D057446:Hydrodynamics; D008297:Male; D008875:Middle Aged; D018084:Ultrasonography, Interventional
keywords: Computer simulation; Coronary artery disease; Dinâmica de fluidos; Doença cardíaca coronária; Fluid dynamics; Intravascular ultrasound; Myocardial fractional flow reserve; Reserva fracionada de fluxo miocárdico; Simulação computorizada; Ultra-sonografia intravascular