title: Longitudinal necrotic shafts near TCFAs--a potential novel mechanism for plaque rupture to trigger ACS?
abstract: It has been questioned for over 15 years why only less than 20% of TCFAs trigger ACS. We illustrate TCFA rupture into adjacent longitudinal necrotic shafts of massive amounts of thrombogenic material into the blood, leading to catastrophic clot formation. This is the potential mechanism for TCFAs triggering ACS. One case presented also illustrates the dangers of stent edges rupturing TCFAs.
authors.affiliation: Center for Optics and Modern Physics, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Electrical Engineering, Massachusetts Institute of Technology, 77 MA Avenue, Cambridge, MA 02139, USA. Electronic address: mebrezin@mit.edu.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Brezinski
authors.affiliation: Richard and Marion Pearsall Heart Hospital, Geisinger Clinic, Wilkes-Barre, PA 18711, USA.
authors.forename: Kishore J
authors.initials: KJ
authors.lastname: Harjai
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000000981:diagnostic imaging*; D011859:Radiography