title: Duration of breastfeeding and serum PCB 153 concentrations in children.
abstract: Polychlorinated biphenyls (PCBs) are toxic, persistent, and bioaccumulative chemicals which, because of their lipophilic properties, are abundant in human breast milk. Breastfed infants are therefore at risk of being exposed to considerable amounts of PCBs. The commonly used exposure estimations, based solely on breast milk PCB levels and duration of breastfeeding, may lead to exposure misclassification. To improve assessments of exposure to PCBs, we determined PCB 153 serum concentration, as a model substance for PCBs, at the critical time of weaning for each child in 305 breastfed infants from 5 single time point concentration measurements spread over 7 years and data on duration of breastfeeding, using an earlier developed model of the system type. We approximated the dependence of PCB 153 serum concentration, Ctbf, adjusted to cord serum concentration, C0, on nursing period, by a polynomial function Ctbf/C0=0.596+0.278t-0.0047t(2) which reliably predicts exposure to PCB 153 of breastfed infants, important for assessment of dose-outcome relationships. Adjustment of current serum concentrations to cord serum concentration improved validity of exposure assessment.
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: kinga.lancz@szu.sk.
authors.forename: Kinga
authors.initials: K
authors.lastname: Lancz
authors.affiliation: Division of Environmental and Occupational Health, Department of Public Health Sciences, University of California, Davis, CA 95616, USA. Electronic address: ihp@ucdavis.edu.
authors.forename: Irva
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.affiliation: Division of Epidemiology, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: todd_jusko@urmc.rochester.edu.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: lubica.palkovicova@szu.sk.
authors.forename: Lubica
authors.initials: L
authors.lastname: Murínová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: sona.wimmerova@szu.sk.
authors.forename: Soňa
authors.initials: S
authors.lastname: Wimmerová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: eva.sovcikova@szu.sk.
authors.forename: Eva
authors.initials: E
authors.lastname: Sovčíková
authors.affiliation: Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Vazovova 5, 812 43 Bratislava I, Slovakia. Electronic address: ladislav.dedik@stuba.sk.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dedík
authors.affiliation: Research Centre of Progressive Technologies, Faculty of Materials Science and Technology in Trnava, Slovak University of Technology in Bratislava, Hajdóczyho 1, 917 24 Trnava, Slovakia. Electronic address: maximilian.stremy@stuba.sk.
authors.forename: Maximilián
authors.initials: M
authors.lastname: Strémy
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: beata.drobna@szu.sk.
authors.forename: Beata
authors.initials: B
authors.lastname: Drobná
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: rektor@szu.sk.
authors.forename: Dana
authors.initials: D
authors.lastname: Farkašová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Trnovec
mesh_terms: D000328:Adult; D001942:Breast Feeding; D002648:Child; D005260:Female; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000097:blood*
chemical_list: D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl
keywords: Breastfeeding; PCB 153 serum concentration; PCB exposure assessment; Polynomial function; Toxicokinetics