title: Use of PET-CT for the assessment of treatment results in patients with sarcoidosis.
abstract: OBJECTIVE
  Sarcoidosis is a multisystem disease of unknown origin. Determining the involvement and the response to the treatment is important. The aim of this study was to identify the effects of methylprednisolone and indomethacine on metabolic activity and pulmonary function test parameters in patients with sarcoidosis.
  
  
  METHODS
  A total of 24 pulmonary sarcoidosis patients were enrolled in the study. All the patients underwent spirometry and [(18)F]fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) scan before treatment and were divided into two groups according to the necessity of corticosteroid treatment or not. Patients who did not have corticosteroid indication were treated with indomethacine. Symptomatic patients and patients who did not respond to indomethacine treatment received methylprednisolone. Patients were followed up on a monthly basis to determine the response. FDG uptakes as the disease activity were re-evaluated before ending the treatment at the sixth month.
  
  
  RESULTS
  Mean age of patients (16 male, 8 female) was 39.79 (9.3) years. Besides mediastinum and pulmonary parenchyma, extrapulmonary sites were also involved in patients with pulmonary sarcoidosis (distant lymph nodes (upper abdominal, supraclavicular, inguinal, and axillary), liver, and spleen). Although maximum standard uptake values of methylprednisolone group regressed significantly (p < 0.001) after treatment, indomethacine group did not have significant regression (p = 0.345). Despite metabolic regressions, spirometry values of patients did not significantly increase (p > 0.005).
  
  
  CONCLUSIONS
  FDG PET-CT may be useful for determining activity and the efficacy of treatments. Methylprednisolone is effective in reducing metabolic activity but does not lead to improvement in functional parameters.
authors.affiliation: Forensic Science Institution, Ministry of Justice, Istanbul, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Yakar
authors.forename: Fatih
authors.initials: F
authors.lastname: Yakar
authors.forename: Murat
authors.initials: M
authors.lastname: Sezer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bayram
authors.forename: Ezgi Başak
authors.initials: EB
authors.lastname: Erdoğan
authors.forename: Didem
authors.initials: D
authors.lastname: Özkan
authors.forename: Hatice K
authors.initials: HK
authors.lastname: Özçelik
authors.forename: Levent
authors.initials: L
authors.lastname: Tabak
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D017063:Outcome Assessment, Health Care / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012507:Sarcoidosis / Q000175:diagnosis* / Q000628:therapy*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18