title: A network approach to clinical intervention in neurodegenerative diseases.
abstract: Network biology has become a powerful tool to dissect the molecular mechanisms triggering neurodegeneration. Recent developments in network biology have led to the discovery of disease-causing genes, diagnostic biomarkers, and therapeutic targets for several neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's diseases. Network-based approaches have provided the molecular rationale for the relationship among cancer, diabetes, and neurodegenerative diseases, and have uncovered unexpected links between apparently unrelated diseases. Here, we summarize the recent advances in network biology to untangle the molecular underpinnings giving rise to the most prevalent neurodegenerative diseases. We propose that network analysis provides a feasible and practical tool for identifying biologically meaningful biomarkers and potential therapeutic targets for clinical intervention in neurodegenerative diseases.
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064-3037, USA.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Santiago
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064-3037, USA. Electronic address: judy.potashkin@rosalindfranklin.edu.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Potashkin
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000235:genetics; D049490:Systems Biology / Q000379:methods*
keywords: Alzheimer's disease; Parkinson's disease; network biology; neurodegenerative diseases