title: Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening.
abstract: BACKGROUND
  There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening.
  
  
  OBJECTIVE
  The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients.
  
  
  METHODS
  A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 µg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN.
  
  
  RESULTS
  An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p = 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p = 0.2) or specificity (96.5%, 97.3%; p = 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4-3.1), age (50-65, >65 years) (OR 2.1, 95% CI 1.1-4.3; OR 2.7, 95% CI 1.2-6.1), previous colonoscopy (OR 0.4, 95% CI 0.2-0.9) and FIT ≥20 µg/g feces (OR 17.7, 95% CI 10.8-29.1) were associated with AN diagnosis.
  
  
  CONCLUSIONS
  FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts.
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Cubiella
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: Castro
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Hernandez
authors.affiliation: 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain ; Department of Clinical Analysis, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: González-Mao
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Rivera
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
authors.forename: Felipe
authors.initials: F
authors.lastname: Iglesias
authors.affiliation: Research Group: Neurocommunication Advertising and Policy, University of Vigo, Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Alves
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Cid
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Soto
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Luisa
authors.initials: L
authors.lastname: De-Castro
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Vega
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Hermo
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Macenlle
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Martínez
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain ; 'IBIV' Institute of Biomedical Research of Vigo, Vigo, Spain.
authors.forename: Pamela
authors.initials: P
authors.lastname: Estevez
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Estela
authors.initials: E
authors.lastname: Cid
authors.affiliation: Donostia Hospital, Biodonostia Institute, University of the Basque Country UPV/EHU, CIBERehd , San Sebastian, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Herreros-Villanueva
authors.affiliation: Programa de Cribado de Cáncer Colorrectal, Servicio Vasco de Salud, País Vasco, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Portillo
authors.affiliation: Programa de Cribado de Cáncer Colorrectal, Servicio Vasco de Salud, País Vasco, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Fernández-Seara
keywords: Colorectal cancer; colonoscopy; colorectal adenoma; colorectal cancer screening; familial colorectal cancer; fecal immunochemical test; sensitivity and specificity