title: The Spanish Burden of Disease 2010: Neurological, mental and substance use disorders.
abstract: BACKGROUND
  We used data from the Global Burden of Disease, Injuries, and Risk Factors Study 2010 to report on the burden of neuropsychiatric disorders in Spain.
  
  
  METHODS
  The summary measure of burden used in the study was the disability-adjusted life-year (DALY), which sums of the years of life lost due to premature mortality (YLLs) and the years lived with disability (YLDs). DALYs were adjusted for comorbidity and estimated with 95% uncertainty intervals.
  
  
  RESULTS
  The burden of neuropsychiatric disorders accounted for 18.4% of total all-cause DALYs generated in Spain for 2010. Within this group, the top five leading causes of DALYs were: depressive disorders, Alzheimer's disease, migraine, substance-use disorders, and anxiety disorder, which accounted for 70.9% of all DALYs due to neuropsychiatric disorders. Neurological disorders represented 5.03% of total all cause YLLs, whereas mental and substance-use disorders accounted for 0.8%. Mental and substance-use disorders accounted for 22.4% of total YLDs, with depression being the most disabling disorder. Neurological disorders represented 8.3% of total YLDs.
  
  
  CONCLUSIONS
  Neuropsychiatric disorders were one of the leading causes of disability in 2010. This finding contributes to our understanding of the burden of neuropsychiatric disorders in the Spanish population and highlights the importance of prioritising neuropsychiatric disorders in the Spanish public health system.
authors.affiliation: Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Sant Boi de Llobregat, Barcelona, España; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, España.
authors.forename: Elvira
authors.initials: E
authors.lastname: Lara
authors.affiliation: Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Sant Boi de Llobregat, Barcelona, España; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, España.
authors.forename: Noé
authors.initials: N
authors.lastname: Garin
authors.affiliation: School of Population Health, University of Queensland, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia; University of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, EE. UU.
authors.forename: Alize J
authors.initials: AJ
authors.lastname: Ferrari
authors.affiliation: Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Sant Boi de Llobregat, Barcelona, España; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, España.
authors.forename: Stefanos
authors.initials: S
authors.lastname: Tyrovolas
authors.affiliation: Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Sant Boi de Llobregat, Barcelona, España; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Olaya
authors.affiliation: Institut d'Investigació Biomèdica de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España.
authors.forename: Lidia
authors.initials: L
authors.lastname: Sànchez-Riera
authors.affiliation: School of Population Health, University of Queensland, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia; University of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, EE. UU.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Whiteford
authors.affiliation: Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Sant Boi de Llobregat, Barcelona, España; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, España. Electronic address: jmharo@pssjd.org.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Haro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D001523:Mental Disorders / Q000401:mortality*; D008875:Middle Aged; D061213:Mortality, Premature; D009422:Nervous System Diseases / Q000401:mortality*; D019057:Quality-Adjusted Life Years; D013030:Spain / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000401:mortality; D055815:Young Adult
keywords: Años de vida ajustados por discapacidad; Burden of disease; Carga de la enfermedad; Disability-adjusted life-years; Enfermedades mentales; Enfermedades neurológicas; Enfermedades por consumo de sustancias; España; Mental disorders; Neurological disorders; Spain; Substance use disorders