title: [Specificities of the logopenic variant of primary progressive aphasia].
abstract: The logopenic variant of primary progressive aphasia is a syndrome with neuropsychological and linguistic specificities, including phonological loop impairment for which diagnosis is currently mainly based on the exclusion of the two other variants, semantic and nonfluent/agrammatic primary progressive aphasia. The syndrome may be underdiagnosed due (1) to mild language difficulties during the early stages of the disease or (2) to being mistaken for mild cognitive impairment or Alzheimer's disease when the evaluation of episodic memory is based on verbal material and (3) finally, it is not uncommon that the disorders are attributed to psychiatric co-morbidities such as, for example, anxiety. Moreover, compared to other variants of primary progressive aphasia, brain abnormalities are different. The left temporoparietal junction is initially affected. Neuropathology and biomarkers (cerebrospinal fluid, molecular amyloid nuclear imaging) frequently reveal Alzheimer's disease. Consequently this variant of primary progressive aphasia does not fall under the traditional concept of frontotemporal lobar degeneration. These distinctive features highlight the utility of correct diagnosis, classification, and use of biomarkers to show the neuropathological processes underlying logopenic primary progressive aphasia. The logopenic variant of primary progressive aphasia is a specific form of Alzheimer's disease frequently presenting a rapid decline; specific linguistic therapies are needed. Further investigation of this syndrome is needed to refine screening, improve diagnostic criteria and better understand the epidemiology and the biological mechanisms involved.
authors.affiliation: CMRR, service de neurologie, CHU, 2, boulevard Fleming, 25030 Besançon, France; Centre Leenaards de la mémoire, CHUV, Lausanne, Suisse. Electronic address: eloi.magnin@laposte.net.
authors.forename: E
authors.initials: E
authors.lastname: Magnin
authors.affiliation: CMRR Paris-Sud, AP-HP, 75013 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Teichmann
authors.affiliation: CMRR, CHU de Rouen, 76000 Rouen, France.
authors.forename: O
authors.initials: O
authors.lastname: Martinaud
authors.affiliation: CMRR, CHU de Grenoble, 38000 Grenoble, France.
authors.forename: O
authors.initials: O
authors.lastname: Moreaud
authors.affiliation: CMRR, service de neurologie, CHU, 2, boulevard Fleming, 25030 Besançon, France.
authors.forename: I
authors.initials: I
authors.lastname: Ryff
authors.affiliation: CMRR, CHU de Rennes, 35000 Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Belliard
authors.affiliation: CMRR, CHU de Toulouse, 31000 Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Pariente
authors.affiliation: CMRR, service de neurologie, CHU, 2, boulevard Fleming, 25030 Besançon, France.
authors.forename: T
authors.initials: T
authors.lastname: Moulin
authors.affiliation: CMRR, service de neurologie, CHU, 2, boulevard Fleming, 25030 Besançon, France.
authors.forename: P
authors.initials: P
authors.lastname: Vandel
authors.affiliation: CMRR Paris-Sud, AP-HP, 75013 Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Démonet
mesh_terms: D018888:Aphasia, Primary Progressive / Q000145:classification* / Q000175:diagnosis*; D001519:Behavior; D015897:Comorbidity; D006801:Humans; D007807:Language Tests; D009068:Movement; D059906:Neuroimaging / Q000379:methods; D009483:Neuropsychological Tests; D012660:Semantics
keywords: Alzheimer's disease; Aphasie progressive primaire; Biomarkers; Biomarqueurs; Logopenic; Logopénique; Maladie d’Alzheimer; Neuropsychologie; Neuropsychology; Primary progressive aphasia