title: Rigor or mortis: best practices for preclinical research in neuroscience.
abstract: Numerous recent reports document a lack of reproducibility of preclinical studies, raising concerns about potential lack of rigor. Examples of lack of rigor have been extensively documented and proposals for practices to improve rigor are appearing. Here, we discuss some of the details and implications of previously proposed best practices and consider some new ones, focusing on preclinical studies relevant to human neurological and psychiatric disorders.
authors.affiliation: Reeve-Irvine Research Center, Departments of Anatomy & Neurobiology, Neurobiology & Behavior, and Neurosurgery, University of California Irvine School of Medicine, 837 Health Science Road, Irvine, CA 92697-4265, USA. Electronic address: osteward@uci.edu.
authors.forename: Oswald
authors.initials: O
authors.lastname: Steward
authors.affiliation: Neuroscience Research Unit, Pfizer, Inc., 610 Main Street, 5(th) floor, Cambridge, MA 02139, USA. Electronic address: rita.balice-gordon@pfizer.com.
authors.forename: Rita
authors.initials: R
authors.lastname: Balice-Gordon
mesh_terms: D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000628:therapy*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000628:therapy*; D009488:Neurosciences; D057170:Translational Research, Biomedical