title: Evaluation of 5-aminolevulinic acid-mediated photorejuvenation of neck skin.
abstract: OBJECTIVE
  To evaluate the outcomes of the combination of red light or intense pulsed laser (IPL) with 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) in the treatment of photodamaged neck skin.
  
  
  METHODS
  The anterior of the neck was divided into four 2 cm × 2 cm sections and randomly assigned to red-light, red-light-PDT, IPL or IPL-PDT group. ALA cream of 5% was applied to PDT regions for 2h prior to light irradiation. Treatment was repeated once. The stratum corneum (SC) hydration, transepidermal water loss (TEWL), L(*), a(*), b(*) values, melanin index (MI), erythema index (EI), skin elasticity and skin thickness were examined by a blinded investigator. The function and volume of thyroid were also measured.
  
  
  RESULTS
  After red-light-PDT, IPL-PDT and IPL treatment, the appearance of photoaging lesion was improved. The SC hydration, L(*) value, elasticity and thickness increased, whereas the TEWL and MI value decreased. These changes in red-light-PDT and IPL-PDT group were more obvious than IPL group. The a(*) and EI value increased in red-light-PDT group. No significant change was noticed in red-light group. Partial irradiation of the thyroid did not affect the function and volume of the thyroid.
  
  
  CONCLUSIONS
  IPL-PDT and red-light-PDT showed better rejuvenation effect than IPL or red light alone on the neck skin.
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ji
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Yi-mei
authors.initials: YM
authors.lastname: Tan
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Ling-lin
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Pei-ru
authors.initials: PR
authors.lastname: Wang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: De-gang
authors.initials: DG
authors.lastname: Yang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Normal University, Fuzhou, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China.
authors.forename: Shun-ying
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai 200050, China. Electronic address: xlwang2001@aliyun.com.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000528:radiation effects; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012060:Rejuvenation / Q000502:physiology; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects / Q000528:radiation effects; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: 5-Aminolevulinic acid; IPL; Photoaging; Photodynamic therapy; Red light; Thyroid