title: Elastin biology and tissue engineering with adult cells.
abstract: The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.
authors.forename: Cassandra B
authors.initials: CB
authors.lastname: Saitow
authors.forename: Steven G
authors.initials: SG
authors.lastname: Wise
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Weiss
authors.forename: John J
authors.initials: JJ
authors.lastname: Castellot
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004547:Elastic Tissue / Q000378:metabolism; D004549:Elastin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009130:Muscle, Smooth / Q000166:cytology / Q000378:metabolism; D011485:Protein Binding; D023822:Tissue Engineering; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology
chemical_list: D004549:Elastin