title: Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
abstract: BACKGROUND
  Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited.
  
  
  METHODS
  We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants.
  
  
  RESULTS
  During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant.
  
  
  CONCLUSIONS
  Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan. Electronic address: iso@pbhel.med.osaka-u.ac.jp.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.affiliation: Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noda
authors.affiliation: Chiba Prefectural Institute of Public Health, Nitona Government Office Building, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8715, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.affiliation: Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kiyama
authors.affiliation: Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Okada
authors.affiliation: Total Medical Support Center, Ehime University Hospital, 454 Shitsukawa, Toon, 791-0295, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hitsumoto
authors.affiliation: Department of Environmental Health and Social Medicine, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791-0295, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanigawa
authors.affiliation: Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
mesh_terms: D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood* / Q000473:pathology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D020521:Stroke / Q000503:physiopathology; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Fasting; Follow-up studies; Ischemic heart disease; Ischemic stroke; Non-fasting; Triglycerides