title: Genetic determinants in ischaemic stroke subtypes: seven year findings and a review.
abstract: Stroke is a global health problem and a leading cause of disability worldwide. There have been numerable studies undertaking research on different aspects of ischaemic stroke employing various epidemiological, clinical and molecular parameters. Nevertheless ischaemic stroke being a complex disorder with different subtypes demands equal attention towards its subtypes too. Since there has been enough evidence that disposition to certain subtype is genetically determined and there is a distinct mechanism that influences its development, association studies should focus on subtypes simultaneously while studying specific genes. Data from such studies will thus provide better and intricate findings with regard to heterogenous ischaemic stroke. In the present review we discuss the genes studied by our group over a period of seven years in association with stroke subtypes in a South Indian population and correlate the findings with similar genetic studies from other populations so as to provide an overview of various genes involved in the pathogenesis of ischaemic stroke subtypes.
authors.affiliation: Centre for Human Genetics, School of Health Sciences, Central University of Punjab, Bathinda, Punjab, India. Electronic address: anjanadurani@yahoo.co.in.
authors.forename: Anjana
authors.initials: A
authors.lastname: Munshi
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India; Dr. NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India.
authors.forename: Satrupa
authors.initials: S
authors.lastname: Das
authors.affiliation: Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.
authors.forename: Subhash
authors.initials: S
authors.lastname: Kaul
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005843:Geography; D006801:Humans; D007194:India; D007511:Ischemia / Q000208:ethnology / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009462:Neurology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D020521:Stroke / Q000208:ethnology / Q000235:genetics*; D014057:Tomography, X-Ray Computed
keywords: Genes; Ischaemic stroke; Polymorphisms; Stroke subtypes; TOAST classification