title: A population-based study on the association between statin use and sudden sensorineural hearing loss.
abstract: OBJECTIVE
  No study has reported the relationship between statin use and sudden sensorineural hearing loss (SSNHL). In this study, we examined the association between statin use and SSNHL using a population-based dataset.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  Taiwan.
  
  
  METHODS
  The study sample was selected from the Taiwan Longitudinal Health Insurance Database. We identified 1263 subjects aged ≥40 years with SSNHL and 6315 sex-, age-, hypertension-, and coronary heart disease-matched controls. We used conditional logistic regression to compute the odds ratio (OR) for having been a previous statin user between cases and controls. Furthermore, we performed conditional logistic regression to explore the relationship of regular and irregular statin users with SSNHL.
  
  
  RESULTS
  There was a significant difference in the prevalence of statin use between cases and controls (27.2% vs 21.3%, respectively; P < .001). The OR of statin use before the index date for cases was 1.36 (95% confidence interval [CI], 1.18-1.57) compared to controls after taking gender, age group, hypertension, coronary heart disease, diabetes, renal disease, and hyperlipidemia into consideration. Furthermore, compared to controls, the adjusted ORs of regular and irregular statin use for cases were 1.30 (95% CI, 1.11-1.52) and 1.49 (95% CI, 1.11-1.93), respectively, compared to controls.
  
  
  CONCLUSIONS
  This study found that SSNHL was significantly associated with previous statin use.
authors.affiliation: Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Shiu-Dong
authors.initials: SD
authors.lastname: Chung
authors.affiliation: Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei, Taiwan Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
authors.forename: Chao-Hung
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Shih-Han
authors.initials: SH
authors.lastname: Hung
authors.affiliation: School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
authors.forename: Herng-Ching
authors.initials: HC
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Taipei Medical University, Taipei, Taiwan Department of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan shiuan@tmu.edu.tw.
authors.forename: Li-Hsuan
authors.initials: LH
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: hearing loss; statin; sudden hearing loss