title: Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface.
abstract: In this paper, we chose diffident kinds of ionic liquids to optimal selection an optimal one to extract alkaloids from Phellodendron amurense Rupr. Four ionic liquids with diffident carbon chains or anions have been investigated and 1-butyl-3-methylimidazolium bromide with best productivity. Then, selections have been optimized in different conditions, including concentration of ionic liquid, time for ultrasonic treatment, ultrasonic power and solid-liquid ratio. Moreover, three conditions have been comprehensively assessment by response surface methodology, the optimal conditions were determined as follows ultrasonic power 100 W, extraction time 75 min and ratio of solvent to raw material 1:14. Under these conditions, the yield% (MIX) was 106.7% (extracted by heat reflux being defined 100%). Comparing with other methods, the advantages are saving conserving, time saving, high yield% and especially pollution-free.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China; Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No. 26 Hexing Road, Harbin City, Heilongjiang Province 150040, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China; Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No. 26 Hexing Road, Harbin City, Heilongjiang Province 150040, China. Electronic address: liqy@zjut.edu.cn.
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No. 26 Hexing Road, Harbin City, Heilongjiang Province 150040, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D059625:Liquid-Liquid Extraction / Q000379:methods*; D032102:Phellodendron / Q000737:chemistry*; D000069453:Ultrasonic Waves
chemical_list: D000470:Alkaloids
keywords: Extraction; Ionic liquid; Phellodendron amurense Rupr; Response surface; Ultrasonic