title: Synthesis, structure, spectral characterization, electrochemistry and evaluation of antibacterial potentiality of a novel oxime-based palladium(II) compound.
abstract: The title monomeric Pd(II) compound, [Pd(L)(Cl)], was synthesized in moderate yield out of the reaction of equimolar proportion of Na2[PdCl4] and 3-[(5-bromo-2-hydroxy-benzylidene)-hydrazono]-butan-2-one oxime (LH) in tetrahydrofuran milieu. LH is a 1:1 Schiff-base condensate of 2,3-butanedionemonoxime monohydrazone and 5-bromosalicylaldehyde. [Pd(L)(Cl)] has been characterized by C, H and N microanalyses, (1)H and (13)C NMR, FAB-MS, FT-IR, Raman spectra, UV-Vis spectra and molar electrical conductivity measurements. [Pd(L)(Cl)] is diamagnetic. Structural elucidation reveals that the palladium center in [Pd(L)(Cl)] is nested in 'N2OCl' coordination environment. The geometry around Pd in [Pd(L)(Cl)] is distorted square-planar. The redox behavior of [Pd(L)(Cl)] in DMF shows a reduction couple, Pd(II)/Pd(I) at -0.836 V versus Ag/AgCl. The in vitro antimicrobial activity of [Pd(L)(Cl)] was screened against both Gram-positive and Gram-negative human pathogenic bacteria. This bioactivity was substantiated with SEM study. [Pd(L)(Cl)] exhibits satisfactory bactericidal as well as bacteriostatic activity.
authors.affiliation: Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata, West Bengal 700 032, India.
authors.forename: Nirmalya
authors.initials: N
authors.lastname: Bandyopadhyay
authors.affiliation: Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, 92 Wucheng Road, Taiyuan, Shanxi 030006, People's Republic of China.
authors.forename: Miaoli
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, 92 Wucheng Road, Taiyuan, Shanxi 030006, People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Lu
authors.affiliation: Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Mitra
authors.affiliation: Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
authors.forename: Mousumi
authors.initials: M
authors.lastname: Das
authors.affiliation: Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
authors.forename: Piu
authors.initials: P
authors.lastname: Das
authors.affiliation: Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India. Electronic address: asamanta61@yahoo.co.in.
authors.forename: Amalesh
authors.initials: A
authors.lastname: Samanta
authors.affiliation: Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata, West Bengal 700 032, India. Electronic address: jnan_naskar@yahoo.co.in.
authors.forename: Jnan Prakash
authors.initials: JP
authors.lastname: Naskar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055664:Electrochemical Techniques; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D010091:Oximes; D010165:Palladium
keywords: Antibacterial; Crystal structure; Oxime; Palladium; Redox; SEM study