title: Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii.
abstract: One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 μg/mL.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Da-Song
authors.initials: DS
authors.lastname: Yang
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Wei
authors.affiliation: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Peng
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Shuang-Mei
authors.initials: SM
authors.lastname: Wang
authors.affiliation: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Sun
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Yang
authors.affiliation: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors.forename: Ke-Chun
authors.initials: KC
authors.lastname: Liu
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology; Germplasm Bank of Wild Species in Southwest China; Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: li_xiaoli11@mail.kib.ac.cn.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D054876:Prenylation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D005419:Flavonoids; C000597672:kurzphenol A
keywords: Cytotoxicity; Euphorbiaceae; Macaranga kurzii; Prenylated bibenzyls; Prenylated flavonoids