title: Immunohistochemical HER2 expression not associated with clinicopathological characteristics of stage I-III gastric cancer patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of human epidermal growth factor receptor 2 (HER2) expression with clinicopathological characteristics of resectable gastric cancer patients.
  
  
  METHODS
  A total of 394 stage I-III surgical gastric cancer patients who were detected of immunohistochemical (IHC) HER2 expression postoperatively were included in this retrospective study. Association of IHC HER2 over-expression (3+) rate with clinicopathological characteristics was tested by univariate and multivariate analyses.
  
  
  RESULTS
  IHC HER2 over-expression rate was 5.1% (95% CI 3.1%-7.7%). By univariate analyses, none of the clinicopathological characteristics was associated with the IHC HER2 over-expression compared to negative expression (0/1+) (p>0.05), with the exception of a higher rate (12.2%) of IHC HER2 (3+) in moderate differentiation subset (p=0.02). However, the multivariate analyses didn’t selected any characteristic as an independent risk factor of IHC HER2 over-expression or the combination of IHC HER2 (2/3+).
  
  
  CONCLUSIONS
  IHC HER2 over-expression rate is relatively low among stage I-III gastric cancer patients, and might be generally not associated with clinicopathological characteristics.
authors.forename: Xin-Zu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Wei-Han
authors.initials: WH
authors.lastname: Zhang
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Yao
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Zong-Guang
authors.initials: ZG
authors.lastname: Zhou
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Chen
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Mo
authors.forename: Jian-Kun
authors.initials: JK
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016017:Odds Ratio; D011237:Predictive Value of Tests; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human