title: Usefulness of S100A12 as a prognostic biomarker for adverse events in patients with heart failure.
abstract: OBJECTIVE
  S100A12 has been proposed as a novel pivotal factor in inflammation produced by granulocytes. The purpose of this study was to investigate the relationship between S100A12 and chronic heart failure (CHF).
  
  
  METHODS
  One hundred and seventy-seven patients with CHF and 66 subjects without CHF were included in this study. Plasma levels of S100A12 and high-sensitivity C-reactive protein (hs-CRP) were measured in all participants. After a follow-up period of 18months for CHF patients, major cardiovascular events (MCE), including cardiac death and rehospitalization for heart failure, were recorded.
  
  
  RESULTS
  Plasma levels of S100A12 were significantly higher in CHF patients than in control subjects (P<0.001) and positively correlated with hs-CRP (r=0.316, P<0.001). S100A12 levels were also higher in MCE patients than in MCE-free patients. The occurrence of MCE increased with advancing plasma S100A12 levels by stratification according to quartiles (Q4 vs Q1, P=0.015). Cox proportional hazards regression analysis revealed that S100A12 was an independent risk factor for MCE in CHF patients (P=0.009).
  
  
  CONCLUSIONS
  S100A12 is a potential biomarker of CHF that may provide important information regarding the prediction of MCE in patients with CHF.
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China; School of Medicine, Nankai University, Tianjin China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: He
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China.
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China.
authors.forename: Rui-Jun
authors.initials: RJ
authors.lastname: Li
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China; School of Medicine, Nankai University, Tianjin China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mu
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China; School of Medicine, Nankai University, Tianjin China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China.
authors.forename: Fen-Fen
authors.initials: FF
authors.lastname: Wu
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing China. Electronic address: wangll63@126.com.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing China. Electronic address: hekl301@aliyun.com.
authors.forename: Kun-Lun
authors.initials: KL
authors.lastname: He
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission / Q000639:trends; D011379:Prognosis; D000067616:S100A12 Protein / Q000097:blood*
chemical_list: D015415:Biomarkers; D000067616:S100A12 Protein; C090441:S100A12 protein, human
keywords: Heart failure; Inflammation; S100A12; hs-CRP