title: [Catheterization and fungal infection risk in the University Hospital of Tlemcen: epidemiology and susceptibility to antifungals].
abstract: Fungal infections are a major cause of morbidity and mortality, and are frequently associated with the implantation of vascular catheters, especially in immune-compromised patients. Unfortunately, the therapeutic arsenal available for the treatment of these infections, caused generally by the yeasts of the genus Candida is still limited because of the toxicity and/or of the emergence of resistance against some antifungal agents. That is why we have undertaken this study, which is to determine the incidence and the degree of sensitivity of Candida spp., isolated from peripheral venous catheters at the University Hospital of Tlemcen (Algeria) to caspofungin and amphotericin B. The results show that the rate of colonization of vascular catheters was 19 % by yeasts of Candida spp., of which 60 % are Candida parapsilosis, 20 % Candida albicans, 14.3 % Candida glabrata and 5.7 % Candida famata. The minimum inhibitory concentrations (MIC) for amphotericin B are between 0.5 and 2 μg/mL and for caspofungin, they are between 0.125 and 2 μg/mL.
authors.affiliation: Laboratoire antibiotiques antifongiques, physicochimie synthèse et activité biologique, université de Tlemcen, BP-128 K-Cerisier, Tlemcen, Algérie. Electronic address: sa.biologie@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Seghir
authors.affiliation: Laboratoire antibiotiques antifongiques, physicochimie synthèse et activité biologique, université de Tlemcen, BP-128 K-Cerisier, Tlemcen, Algérie.
authors.forename: Z
authors.initials: Z
authors.lastname: Boucherit-Otmani
authors.affiliation: Laboratoire antibiotiques antifongiques, physicochimie synthèse et activité biologique, université de Tlemcen, BP-128 K-Cerisier, Tlemcen, Algérie.
authors.forename: L
authors.initials: L
authors.lastname: Belkherroubi-Sari
authors.affiliation: Laboratoire antibiotiques antifongiques, physicochimie synthèse et activité biologique, université de Tlemcen, BP-128 K-Cerisier, Tlemcen, Algérie; Centre Universitaire de Naâma, Naâma, Algérie.
authors.forename: K
authors.initials: K
authors.lastname: Boucherit
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria / Q000453:epidemiology; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D002404:Catheterization / Q000009:adverse effects / Q000706:statistics & numerical data; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000187:drug effects; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012307:Risk Factors; D062666:Vascular Access Devices / Q000009:adverse effects / Q000382:microbiology
chemical_list: D000935:Antifungal Agents
keywords: Amphotericin B; Amphotéricine B; Antifungal susceptibility; Candida; Caspofungin; Caspofungine; Catheter; Cathéter; Concentration minimale inhibitrice; Infection nosocomiale; Minimum inhibitory concentration; Nosocomial infection; Sensibilité aux antifongiques