title: [The role of subclinical inflammation in progression of multifocal atherosclerosis during one year after myocardial infarction].
abstract: OBJECTIVE
  To elucidate role of subclinical inflammation in progression of atherosclerotic process in magistral noncoronary arteries in patients during one year after ST-elevation myocardial infarction (MI).
  
  
  METHODS
  We examined 168 men with MI (mean age 59.5 years). All patients during hospitalization underwent coronary angiography and color duplex scanning of brachiocephalic arteries. In a year ultrasound study of noncoronary vessels was repeated and progression of atherosclerosis assessed. Parameters of inflammation in blood serum were measured on days 10-14 of MI and after one year.
  
  
  RESULTS
  At repeat study most patients demonstrated progression of noncoronary atherosclerosis. Some biomarkers measured during inhospital phase of MI (low concentration of anti-inflammatory interleukin 10 - IL-10, elevated N-terminal pro brain natriuretic peptide) allowed to distinguish group of patients with subsequent progression of noncoronary atherosclerosis. Elevated concentrations of C-reactive protein and 11-10 registered in a year after MI were also associated with more severe progression of atherosclerosis. Serum levels of neopterin and IL-12 remained stable in patients with and decreased in patients without pronounced progression of atherosclerosis.
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
authors.forename: E N
authors.initials: EN
authors.lastname: Usol'tseva
authors.forename: V V
authors.initials: VV
authors.lastname: Kashtalap
authors.forename: I S
authors.initials: IS
authors.lastname: Kolomytseva
authors.forename: I N
authors.initials: IN
authors.lastname: Sizova
authors.forename: M A
authors.initials: MA
authors.lastname: Volykova
authors.forename: I A
authors.initials: IA
authors.lastname: Shibanova
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016122:Brachiocephalic Trunk / Q000000981:diagnostic imaging; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D018450:Disease Progression; D004562:Electrocardiography; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000097:blood; D019798:Neopterin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018615:Ultrasonography, Doppler, Color / Q000379:methods
chemical_list: D015415:Biomarkers; D007378:Interleukins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D019798:Neopterin; D002097:C-Reactive Protein