title: Ambient GABA modulates septo-hippocampal inhibitory terminals via  presynaptic GABAb receptors.
abstract: The septo-hippocampal GABAergic pathway connects inhibitory neurons in the medial septum with hippocampal interneurons. Phasic release of GABA from septo-hippocampal terminals is thought to play an important role in shaping hippocampal network activity during behavior. Here, we found that GABA release from septo-hippocampal terminals is under negative feedback from the hippocampal local inhibitory network. We found that the strength of septo-hippocampal GABAergic inhibition is constrained by presynaptic GABAb receptors that are activated by ambient GABA during states of increased hippocampal network activity.
authors.forename: Gergely F
authors.initials: GF
authors.lastname: Turi
authors.forename: Gabor
authors.initials: G
authors.lastname: Wittmann
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lechan
authors.forename: Attila
authors.initials: A
authors.lastname: Losonczy
mesh_terms: D000818:Animals; D005260:Female; D055879:Gene Knock-In Techniques; D006624:Hippocampus / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D008297:Male; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000502:physiology*; D018080:Receptors, GABA-B / Q000378:metabolism*; D020665:Septum of Brain / Q000502:physiology*; D046509:Tissue Culture Techniques; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid