title: Hypertrophic olivary degeneration and cerebrovascular disease: movement in a triangle.
abstract: Hypertrophic olivary degeneration is a rare kind of trans-synaptic degeneration that occurs after lesions of the dentatorubro-olivary pathway. The lesions, commonly unilateral, may result from hemorrhage due to vascular malformation, trauma, surgical intervention or hypertension, tumor, or ischemia. Bilateral cases are extremely rare. This condition is classically associated with development of palatal tremor, but clinical manifestations can include other involuntary movements. We describe 2 cases: unilateral hypertrophic olivary degeneration in a 60-year-old man with contralateral athetosis and neurologic worsening developing several years after a pontine hemorrhage and bilateral hypertrophic olivary degeneration in a 77-year-old woman with development of palatal tremor, probably secondary to pontine ischemic lesions (small vessel disease).
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal. Electronic address: filipasantos@hotmail.com.
authors.forename: Ana Filipa
authors.initials: AF
authors.lastname: Santos
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Rocha
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: Sara
authors.initials: S
authors.lastname: Varanda
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Pinho
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Rodrigues
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Ramalho Fontes
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Soares-Fernandes
authors.affiliation: Neurology Department, Hospital de Braga, Braga, Portugal.
authors.forename: Carla
authors.initials: C
authors.lastname: Ferreira
mesh_terms: D000368:Aged; D002561:Cerebrovascular Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology*; D009847:Olivary Nucleus / Q000473:pathology*; D014202:Tremor / Q000473:pathology
keywords: Hypertrophic olivary degeneration; athetosis; palatal tremor; stroke