title: A population-based five-year study on the risk of stroke in patients with osteoporosis in Taiwan.
abstract: OBJECTIVE
  Osteoporosis and stroke are common diseases in elder patients. The relationship between these two diseases is unclear. This study was intended to estimate the risk of stroke among elder persons aged ≥ 50 years within five years of being diagnosed with osteoporosis.
  
  
  METHODS
  We retrieved data from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan to perform a nationwide population-based study. There were 2580 patients with osteoporosis aged 50 years of age and older in the study cohort. All of them had at least 2 ambulatory care claims or at least 1 inpatient service claim. Each osteoporotic patient was matched to 5 non-osteoporotic patients based on gender, age, and the index year. Subjects in both groups were followed up for five years. Risk of developing stroke and 5-year stroke-free survival rates were evaluated.
  
  
  RESULTS
  The risk of developing stroke was 1.24 times higher in osteoporotic patients within a 5-year follow-up period compared to an age- and gender-matched cohort without osteoporosis (95% confidence interval = 1.11-1.39; p < 0.001). Patients with osteoporosis also had a significantly lower 5-year stroke-free survival rate.
  
  
  CONCLUSIONS
  Our results indicated that patients with osteoporosis history had higher risk for development of stroke.
authors.affiliation: Department of Health Industry Management, Kainan University, Taoyuan, Taiwan.
authors.forename: Chia-Hsien
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Kuo
authors.affiliation: Department of Obstetrics and Gynecology, Branch of Hsinchu, Taipei Veterans General Hospital, Taiwan.
authors.forename: Hann-Chin
authors.initials: HC
authors.lastname: Yu
authors.affiliation: Department Human Resource, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Yang
authors.affiliation: Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
authors.forename: Yea-Wen
authors.initials: YW
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, Clinical Research Center, Graduate Institute of Injury Prevention and Control, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: kshung25@gmail.com.
authors.forename: Kuo-Sheng
authors.initials: KS
authors.lastname: Hung
authors.affiliation: Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan. Electronic address: wpchang@mail.ypu.edu.tw.
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D013624:Taiwan; D016896:Treatment Outcome; D014505:Urban Population
keywords: NHIRD; Osteoporosis; Population-based study; Stroke; Taiwan