title: NEMA NU 4-Optimized Reconstructions for Therapy Assessment in Cancer Research with the Inveon Small Animal PET/CT System.
abstract: OBJECTIVE
  We compared conventional filtered back-projection (FBP), two-dimensional-ordered subsets expectation maximization (OSEM) and maximum a posteriori (MAP) NEMA NU 4-optimized reconstructions for therapy assessment.
  
  
  METHODS
  Varying reconstruction settings were used to determine the parameters for optimal image quality with two NEMA NU 4 phantom acquisitions. Subsequently, data from two experiments in which nude rats bearing subcutaneous tumors had received a dual PI3K/mTOR inhibitor were reconstructed with the NEMA NU 4-optimized parameters. Mann-Whitney tests were used to compare mean standardized uptake value (SUV(mean)) variations among groups.
  
  
  RESULTS
  All NEMA NU 4-optimized reconstructions showed the same 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) kinetic patterns and detected a significant difference in SUV(mean) relative to day 0 between controls and treated groups for all time points with comparable p values.
  
  
  CONCLUSIONS
  In the framework of therapy assessment in rats bearing subcutaneous tumors, all algorithms available on the Inveon system performed equally.
authors.affiliation: UNICANCER, BioTICLA EA 4656, François Baclesse Cancer Centre, Caen, France.
authors.forename: Charline
authors.initials: C
authors.lastname: Lasnon
authors.forename: Audrey Emmanuelle
authors.initials: AE
authors.lastname: Dugue
authors.forename: Mélanie
authors.initials: M
authors.lastname: Briand
authors.forename: Cécile
authors.initials: C
authors.lastname: Blanc-Fournier
authors.forename: Soizic
authors.initials: S
authors.lastname: Dutoit
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Louis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Aide
mesh_terms: D000465:Algorithms; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry; D005260:Female; D007091:Image Processing, Computer-Assisted; D064847:Multimodal Imaging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D019047:Phantoms, Imaging; D000081082:Phosphoinositide-3 Kinase Inhibitors; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry; D051381:Rats; D011923:Rats, Nude; D012542:Scattering, Radiation; D014057:Tomography, X-Ray Computed
chemical_list: D004791:Enzyme Inhibitors; D000081082:Phosphoinositide-3 Kinase Inhibitors; D019275:Radiopharmaceuticals