title: Effect of positive surgical margins on biochemical failure, biochemical recurrence-free survival, and overall survival after radical prostatectomy: median long-term results.
abstract: The aim of this study was to investigate the median long-term effects of positive surgical margin (PSM) and other prognostic factors on biochemical recurrence-free survival, overall survival, and biochemical failure in patients who underwent radical prostatectomy. Our study included 121 patients with pT2-3N0 disease treated between March 2006 and August 2012. The patients were divided into two groups: those with PSM and those with negative surgical margin (NSM). We analyzed the age, clinical and pathological stages, preoperative and postoperative Gleason scores, duration of the follow-up, adjuvant chemo-/radiotherapy, biochemical failure, biochemical recurrence-free survival, and overall survival in these patients. PSM was found in 25 (20%) patients, whereas 96 patients had NSM. The median follow-up time was 46.6 months (range 12-72 months) for the PSM group and 48.3 months (range 7-149 months) for the NSM group. The biochemical failure rate was 24% in the PSM group and 8.3% in the NSM group (p = 0.029). The biochemical recurrence-free survival was found as 76% in the PSM group and 91.7% in the NSM group. The difference between the groups was not statistically significant (p = 0.06). The overall survival was 100% in both groups. The surgical margins of the radical prostatectomy material is an important pathological indicator for biochemical failure at mid long-term follow-up. We did not find any effect of PSM on overall survival or biochemical recurrence-free survival.
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Huri
authors.affiliation: Department of Urology, Clinic of Dr Sami Ulus Maternity, Children Health and Diseases Training and Research Hospital, Ankara, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Aydogmus
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey. Electronic address: drdoluoglu@yahoo.com.tr.
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Dadali
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Karakan
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Emir
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Cankon
authors.initials: C
authors.lastname: Germiyanoglu
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery*; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors
keywords: Biochemical failure; Prostatectomy; Prostatic neoplasm; Survival