title: Congenital visual pathway abnormalities: a window onto cortical stability and plasticity.
abstract: Sensory systems project information in a highly organized manner to the brain, where it is preserved in maps of the sensory structures. These sensory projections are altered in congenital abnormalities, such as anophthalmia, albinism, achiasma, and hemihydranencephaly. Consequently, these abnormalities, profoundly affect the organization of the visual system. Surprisingly, visual perception remains largely intact, except for anophthalmia. Recent brain imaging advances shed light on the mechanisms that underlie this phenomenon. In contrast to animal models, in humans the plasticity of thalamocortical connections appears limited, thus demonstrating the importance of cortical adaptations. We suggest that congenital visual pathway abnormalities provide a valuable model to investigate the principles of plasticity that make visual representations available for perception and behavior in humans.
authors.affiliation: Department of Ophthalmology, Visual Processing Laboratory, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany. Electronic address: michael.hoffmann@med.ovgu.de.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Hoffmann
authors.affiliation: Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.
authors.forename: Serge O
authors.initials: SO
authors.lastname: Dumoulin
mesh_terms: D000818:Animals; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology / Q000503:physiopathology*; D014795:Visual Pathways / Q000002:abnormalities* / Q000502:physiology / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology
keywords: achiasma; albinism; anophthalmia; hemihydranencephaly; reorganisation; sensory systems; visual pathway abnormalities; visual system