title: Innate immune sensing of nucleic acids from pathogens.
abstract: The innate immune system is important as the first line of defense to sense invading pathogens. Nucleic acids represent critical pathogen signatures that trigger a host proinflammatory immune response. Much progress has been made in understanding how DNA and RNA trigger host defense countermeasures, however, several aspects of how cytosolic nucleic acids are sensed remain unclear. This special issue reviews how the host innate immune system senses nucleic acids from Brucella abortus, Mycobacterium sp and Legionella pneumophila, viral DNA, the role of STING in DNA sensing and inflammatory diseases and the mechanism of viral RNA recognition by the small interfering RNA pathway in Drosophila melanogaster.
authors.affiliation: Universidade Federal de Minas Gerais, Departamento de Bioquímica e Imunologia, Av. Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil. Electronic address: scozeus@icb.ufmg.br.
authors.forename: Sergio C
authors.initials: SC
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000276:immunology; D004279:DNA, Viral / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D009696:Nucleic Acids / Q000276:immunology*; D012329:RNA, Bacterial / Q000276:immunology; D012367:RNA, Viral / Q000276:immunology
chemical_list: D004269:DNA, Bacterial; D004279:DNA, Viral; D009696:Nucleic Acids; D012329:RNA, Bacterial; D012367:RNA, Viral
keywords: Cytosolic sensors; DNA sensing; Innate immunity; RNA receptors; STING; TLRs