title: CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 genetic polymorphisms in chronic myeloid leukemia: a case-control study.
abstract: Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes of GPX1, MnSOD, GSTM1, and GSTT1 polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of the GSTP1 Ile105Val gene polymorphisms may be associated with the risk of developing CML (OR = 2.5; 95% CI = 1.08-5.7; P value = 0.02), while the heterozygous genotype of the CAT C262T polymorphism seems to have a protective effect against CML (OR = 0.59, 95% CI = 0.39-0.89, P value = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded that CAT, GPX, MnSOD, GSTM1, and GSTT1 gene polymorphisms are not associated with the risk of CML. Variant genotype of the GSTP1 Ile105Val gene polymorphisms may contribute to the risk of developing CML.
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bănescu
authors.affiliation: Department of Medical Genetics, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania.
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Trifa
authors.affiliation: Department of Epidemiology, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania.
authors.forename: Septimiu
authors.initials: S
authors.lastname: Voidăzan
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania.
authors.forename: Valeriu G
authors.initials: VG
authors.lastname: Moldovan
authors.affiliation: Hematology Clinic 1, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu Street, 540136 Tirgu Mures, Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Macarie
authors.affiliation: Hematology Clinic 2, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania.
authors.forename: Erzsebeth
authors.initials: E
authors.lastname: Benedek Lazar
authors.affiliation: "Ion Chiricuta" Cancer Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania.
authors.forename: Delia
authors.initials: D
authors.lastname: Dima
authors.affiliation: Pediatric Clinic, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu Street, 540136 Tirgu Mures, Romania.
authors.forename: Carmen
authors.identifier: 0000-0002-8056-1339
authors.initials: C
authors.lastname: Duicu
authors.affiliation: Laboratory Medicine, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu Street, 540136 Tirgu Mures, Romania.
authors.forename: Minodora
authors.initials: M
authors.lastname: Dobreanu
mesh_terms: D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human; C000722067:GPX1 protein, human