title: Plant-based vaccines against viruses.
abstract: Plant-made or "biofarmed" viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.
authors.affiliation: Biopharming Research Unit, Department of Molecular & Cell Biology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Private Bag X3, Rondebosch, 7701, Cape Town, South Africa. ed.rybicki@uct.ac.za.
authors.forename: Edward P
authors.initials: EP
authors.lastname: Rybicki
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D030821:Plants, Genetically Modified / Q000235:genetics* / Q000378:metabolism*; D013678:Technology, Pharmaceutical / Q000379:methods; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D014777:Virus Diseases / Q000517:prevention & control / Q000662:veterinary
chemical_list: D014765:Viral Vaccines