title: [Analysis of linkage disequilibrium and linkage for 12 short tandem repeat loci on chromosome X].
abstract: OBJECTIVE
  To analyze linkage disequilibrium of 12 short tandem repeat loci on chromosome X (X-STR) among an ethnic Han population from Guilin, Guangxi, and to study the genetic linkage and haplotype distributions of such loci in 2 linkage groups.
  
  
  METHODS
  12 X-STR loci including DXS8378, DXS10159, DXS10162, DXS10164, DXS981, DXS6789, DXS7424, DXS101, DXS7133, GATA165B12, GATA31E08 and DXS7423 were genotyped using an AGCU X12 STR PCR Amplification kit. A total of 119 pedigrees were analyzed for linkage and linkage disequilibrium.
  
  
  RESULTS
  Two mutations were found at DXS7424, and 1 mutation was found at DXS10164. A total of 93 haplotypes of DXS10159-DXS10162-DXS10164 were constructed for 261 unrelated males and females, in addition with 167 haplotypes of DXS6789-DXS7424-DXS101-DXS7133. The values of recombination fraction between DXS10159 and DXS10162, DXS10162 and DXS10164, DXS6789 and DXS7424, and DXS7424 and DXS101 were 0.0269, 0.0236, 0.0505 and 0.0438, respectively.
  
  
  CONCLUSIONS
  Linkage disequilibrium of X-STR does not only depend on physical and genetic distances. There was incomplete linkage relationship between loci on DXS10159-DXS1016-DXS10164 and DXS6789-DXS7424-DXS101 linkage groups.
authors.affiliation: Center of Forensic Sciences, Bureau of Public Security of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530012, P. R. China. tangjianpin@hotmail.com.
authors.forename: Qiansu
authors.initials: Q
authors.lastname: Ye
authors.forename: Jianpin
authors.initials: J
authors.lastname: Tang
authors.forename: Zucong
authors.initials: Z
authors.lastname: Chen
authors.forename: Fagui
authors.initials: F
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Hanguang
authors.initials: H
authors.lastname: Lin
authors.forename: Meisen
authors.initials: M
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree; D055815:Young Adult