title: Prognosis of body mass index and chemotherapy dose capping in acute myeloid leukaemia.
abstract: Body Mass Index (BMI) prognosis in acute myeloid leukaemia (AML) is unknown. Capping chemotherapy dose at 2m(2) of body surface area (BSA) is used without any rationale. We assessed whether both of them could be correlated with outcome in 233 AML patients. Thirty three percent were overweight, 10% obese and BSA over 2m(2) was observed in 15%. BMI and BSA>2m(2) were not associated with OS (p=0.16; p=0.39), nor with DFS (p=0.18; p=0.42), nor with CR. OS-associated factors were age (p<0.001), cytogenetic (p=0.002), FLT3-ITD (p=0.01). BMI and chemotherapy dose capping are not pejorative factors on intensively treated AML patients.
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Kempf
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France; INSERM, UMR_S 938, CDR Saint Antoine, F-75012 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Hirsch
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; INSERM, UMR_S 938, CDR Saint Antoine, F-75012 Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Labopin
authors.affiliation: Laboratoire d'Immunologie et Hématologie biologique, Hôpital Saint-Antoine, APHP, Paris, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Viguié
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Isnard
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France; INSERM, UMR_S 938, CDR Saint Antoine, F-75012 Paris, France.
authors.forename: Ruoping
authors.initials: R
authors.lastname: Tang
authors.affiliation: Laboratoire d'Immunologie et Hématologie biologique, Hôpital Saint-Antoine, APHP, Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Marzac
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France.
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Marie
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France; INSERM, UMR_S 938, CDR Saint Antoine, F-75012 Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Service d'hématologie clinique et de thérapie cellulaire, Hôpital Saint-Antoine, APHP, Paris, France; UPMC, Univ Paris 06, GRC n°7, Groupe de Recherche Clinique sur les Myéloproliférations Aiguës et Chroniques MYPAC, Paris, France; INSERM, UMR_S 938, CDR Saint Antoine, F-75012 Paris, France. Electronic address: ollivier.legrand@sat.aphp.fr.
authors.forename: Ollivier
authors.initials: O
authors.lastname: Legrand
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
keywords: AML; BMI; Chemotherapy dose capping; Obesity; Prognosis