title: Hospital mortality following trauma: an analysis of a hospital-based injury surveillance registry in sub-Saharan Africa.
abstract: OBJECTIVE
  Injuries are a significant cause of death and disability, particularly in low- and middle-income countries. Health care systems in resource-poor countries lack personnel and are ill equipped to treat severely injured patients; therefore, many injury-related deaths occur after hospital admission.
  
  
  OBJECTIVE
  This study evaluates the mortality for hospitalized trauma patients at a tertiary care hospital in Malawi.
  
  
  METHODS
  This study is a retrospective analysis of prospectively collected trauma surveillance data. We performed univariate and bivariate analyses to describe the population and logistic regression analysis to identify predictors of mortality.
  
  
  METHODS
  Tertiary care hospital in sub-Saharan Africa.
  
  
  METHODS
  Patients with traumatic injuries admitted to Kamuzu Central Hospital between January 2010 and December 2012.
  
  
  METHODS
  Predictors of in-hospital mortality.
  
  
  RESULTS
  The study population consisted of 7559 patients, with an average age of 27 years (±18 years) and a male predominance of 76%. Road traffic injuries, falls, and assaults were the most common causes of injury. The overall mortality was 4.2%. After adjusting for age, sex, type and mechanism of injury, and shock index, head/spine injuries had the highest odds of mortality, with an odds ratio of 5.80 (2.71-12.40).
  
  
  CONCLUSIONS
  The burden of injuries in sub-Saharan Africa remains high. At this institution, road traffic injuries are the leading cause of injury and injury-related death. The most significant predictor of in-hospital mortality is the presence of head or spinal injury. These findings may be mitigated by a comprehensive injury-prevention effort targeting drivers and other road users and by increased attention and resources dedicated to the treatment of patients with head and/or spine injuries in the hospital setting.
authors.affiliation: Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Anna F
authors.initials: AF
authors.lastname: Tyson
authors.affiliation: Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Varela
authors.affiliation: Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Cairns
authors.affiliation: Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina. Electronic address: anthchar@med.unc.edu.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Charles
mesh_terms: D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D062665:Epidemiological Monitoring; D005260:Female; D005544:Forecasting; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D012042:Registries; D012044:Regression Analysis; D012189:Retrospective Studies; D014947:Wounds and Injuries / Q000401:mortality*
keywords: Medical Knowledge; Patient Care; Systems-Based Practice; developing health care systems; trauma; trauma mortality; trauma sub-Saharan Africa