title: Physiological functions of the TRPM4 channels via protein interactions.
abstract: Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2(+)-activated Ca2(+)-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.
authors.affiliation: School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 136-703, Korea.
authors.forename: Chang-Hoon
authors.initials: CH
authors.lastname: Cho
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 136-791; Department of Physiology, Institute of Health Science and Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju 660-751, Korea.
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Lee
authors.affiliation: School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 136-703; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 136-791, Korea.
authors.forename: Eunju
authors.initials: E
authors.lastname: Kim
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 136-791; Neuroscience Program, University of Science and Technology (UST), Daejeon 305-350, Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Hwang
authors.affiliation: School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 136-703, Korea.
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D034622:RNA Interference; D050053:TRPM Cation Channels / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D050053:TRPM Cation Channels; C437888:TRPM4 protein, human; D002118:Calcium