title: Pulmonary complications of abdominal wall defects.
abstract: The abdominal wall is an integral component of the chest wall. Defects in the ventral abdominal wall alter respiratory mechanics and can impair diaphragm function. Congenital abdominal wall defects also are associated with abnormalities in lung growth and development that lead to pulmonary hypoplasia, pulmonary hypertension, and alterations in thoracic cage formation. Although infants with ventral abdominal wall defects can experience life-threatening pulmonary complications, older children typically experience a more benign respiratory course. Studies of lung and chest wall function in older children and adolescents with congenital abdominal wall defects are few; such investigations could provide strategies for improved respiratory performance, avoidance of respiratory morbidity, and enhanced exercise ability for these children.
authors.affiliation: Professor of Pediatrics, Perelman School of Medicine at The University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia. Electronic address: panitch@email.chop.edu.
authors.forename: Howard B
authors.initials: HB
authors.lastname: Panitch
mesh_terms: D034861:Abdominal Wall / Q000002:abnormalities*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D020139:Gastroschisis / Q000150:complications; D046449:Hernia, Abdominal / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000209:etiology*; D012129:Respiratory Function Tests
keywords: Abdominal wall defects; gastroschisis; omphalocele; prune belly syndrome; pulmonary function