title: Role of G protein-coupled orphan receptors in intestinal inflammation: novel targets in inflammatory bowel diseases.
abstract: A large number of proteins were classified into the family of G protein-coupled receptors (GPCRs). Based on their characteristic serpentine domain, they are called 7 TM receptors. Presently, their ligands and physiological functions remain unknown. In this review, we summarize what is known on these receptors and discuss the potential use of these orphan GPCRs (GPRs) in the induction or maintenance of remission in inflammatory bowel diseases. We focus on GPRs 30, 41, 43, 55, 119, and 120, where scientific evidence supports a potential role in intestinal inflammation.
authors.affiliation: *Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland; and †Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wasilewski
authors.forename: Martin
authors.initials: M
authors.lastname: Storr
authors.forename: Marta
authors.initials: M
authors.lastname: Zielińska
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D058990:Molecular Targeted Therapy; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D043562:Receptors, G-Protein-Coupled