title: Increased incidence of pelvic organ prolapse in women with acromegaly.
abstract: OBJECTIVE
  To evaluate gynecological problems of female patients with acromegaly and the relationship of these problems with the activity of the disease.
  
  
  METHODS
  Thirty-four women with acromegaly and 27 age- and body mass index-matched female healthy controls (HC) were included in the study. Demographic features, medical history, hormonal status and disease activity were obtained. A detailed gynecological examination was performed.
  
  
  RESULTS
  The incidence of pelvic organ prolapse (POP) was higher in patients with acromegaly (53%, n=18) compared to the HC (15%, n=4) (p=0.003). Limiting the analysis to only cases with previous pregnancy, POP was seen in 18 (60%) of 30 cases with acromegaly and in 4 (20%) of 20 of the HC (p=0.005). Additionally, in cases with prior vaginal delivery, POP was present in 18 (60%) of 30 cases with acromegaly and in 4 (24%) of 17 of the HC (p=0.02). The frequency of POP was similar in patients with controlled and uncontrolled acromegaly (p=0.3).
  
  
  CONCLUSIONS
  Acromegaly may facilitate occurrence of pelvic organ prolapse and may cause additional health issues in female cases.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Celik
authors.affiliation: Department of Gynecology and Obstetrics, Istanbul Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Suleyman Engin
authors.initials: SE
authors.lastname: Akhan
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Hatipoglu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey. Electronic address: kadioglup@yahoo.com.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000453:epidemiology*; D012307:Risk Factors
keywords: Acromegaly; Fertility; Gynecological problems; Pelvic organ prolapse; Pregnancy