title: Autonomic dysfunction in multiple sclerosis: implications for exercise.
abstract: Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease.
authors.affiliation: Department of Applied Physiology & Wellness, Southern Methodist University, Dallas, TX, United States.
authors.forename: Mu
authors.initials: M
authors.lastname: Huang
authors.affiliation: Faculty of Health Sciences, University of Sydney, Sydney, Australia.
authors.forename: Ollie
authors.initials: O
authors.lastname: Jay
authors.affiliation: Department of Applied Physiology & Wellness, Southern Methodist University, Dallas, TX, United States; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States. Electronic address: sldavis@smu.edu.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Davis
mesh_terms: D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000209:etiology* / Q000534:rehabilitation*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000534:rehabilitation
keywords: Blood pressure; Cardiovascular; Demyelination; Sweat; Sympathetic nerve activity; Thermoregulation