title: Chitosan-PVP-nano silver oxide wound dressing: in vitro and in vivo evaluation.
abstract: The main aim of this work was to prepare wound healing material with chitosan, poly vinyl pyrrolidone (PVP), silver oxide nanoparticles. The prepared chitosan, chitosan-PVP-nano silver oxide (CPS) films were characterized for their thermal behaviour, morphological properties, mechanical properties, antibacterial properties and wound healing properties. The CPS film found higher antibacterial activity because the materials both chitosan as well as silver oxide poses good antibacterial activity. L929 cell lines were for cytotoxicity study and Adult male albino rats (140-180 g) were used for wound healing study. The prepared film has more wound healing property than of cotton gauge, 100% chitosan and other reported chitosan based dressings.
authors.affiliation: Department of Chemistry, MN National Institute of Technology, Allahabad 211004, U.P., India.
authors.forename: D
authors.initials: D
authors.lastname: Archana
authors.affiliation: Department of Chemistry, MN National Institute of Technology, Allahabad 211004, U.P., India.
authors.forename: Brijesh K
authors.initials: BK
authors.lastname: Singh
authors.affiliation: School of Applied Sciences, Amity University, Gurgaon (Manesar) 122413, Haryana, India.
authors.forename: Joydeep
authors.initials: J
authors.lastname: Dutta
authors.affiliation: Department of Chemistry, MN National Institute of Technology, Allahabad 211004, U.P., India. Electronic address: pkd_437@yahoo.com.
authors.forename: P K
authors.initials: PK
authors.lastname: Dutta
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001684:Biological Dressings; D001696:Biomechanical Phenomena; D048271:Chitosan / Q000737:chemistry*; D053878:Hemolytic Agents / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D051381:Rats; D018030:Silver Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D013818:Thermogravimetry; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D053878:Hemolytic Agents; D010087:Oxides; D018030:Silver Compounds; C040225:disilver oxide; D048271:Chitosan; D011205:Povidone
keywords: Chitosan; PVP; Silver oxide; Wound dressing