title: Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL.
abstract: Based on their ability to balance tolerance and inflammation, antigen presenting cells, such as dendritic cells and macrophages contribute to the maintenance of immune homeostasis as well as the instigation of immune activation. Acting as key sensors of tissue integrity and pathogen invasion, they are well equipped with a wide variety of pattern recognition receptors, to which the C-type lectin family also belongs. C-type lectins are glycan-binding receptors that mediate cell-cell communication and pathogen recognition, besides participating in the endocytosis of antigens for presentation to T cells and the fine-tuning of immune responses. Here we review the current state-of-the-art on the dendritic cell and macrophage-expressed C-type lectin macrophage galactose-type lectin (MGL), highlighting the binding specificities, signaling properties and modulation of innate and adaptive immunity by its human and murine orthologues.
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands.
authors.forename: Yvette
authors.initials: Y
authors.lastname: van Kooyk
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Ilarregui
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands. Electronic address: s.vanvliet@vumc.nl.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: van Vliet
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002241:Carbohydrates / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D037181:Lectins, C-Type / Q000378:metabolism*; D008024:Ligands; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction; D014611:Vaccination / Q000379:methods
chemical_list: D002241:Carbohydrates; D037181:Lectins, C-Type; D008024:Ligands
keywords: C-type lectin; Dendritic cells; Macrophages; T cells; Tn antigen