title: [Networks involving quorum sensing, cyclic-di-GMP and nitric oxide on biofilm production in bacteria].
abstract: Bacterial biofilms are ubiquitous in nature, and their flexibility is derived in part from a complex extracellular matrix that can be made-to-order to cope with environmental demand. Although common developmental stages leading to biofilm formation have been described, an in-depth knowledge of genetic and signaling is required to understand biofilm formation. Bacteria detect changes in population density by quorum sensing and particular environmental conditions, using signals such as cyclic di-GMP or nitric oxide. The significance of understanding these signaling pathways lies in that they control a broad variety of functions such as biofilm formation, and motility, providing benefits to bacteria as regards host colonization, defense against competitors, and adaptation to changing environments. Due to the importance of these features, we here review the signaling network and regulatory connections among quorum sensing, c-di-GMP and nitric oxide involving biofilm formation.
authors.affiliation: Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, México.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ramírez-Mata
authors.affiliation: Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, México.
authors.forename: Ileana J
authors.initials: IJ
authors.lastname: Fernández-Domínguez
authors.affiliation: Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, México.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Nuñez-Reza
authors.affiliation: Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, México.
authors.forename: María L
authors.initials: ML
authors.lastname: Xiqui-Vázquez
authors.affiliation: Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, México. Electronic address: beatriz.baca@correo.buap.mx.
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Baca
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology; D001426:Bacterial Proteins / Q000502:physiology; D018441:Biofilms / Q000254:growth & development*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D008954:Models, Biological; D009569:Nitric Oxide / Q000502:physiology*; D053038:Quorum Sensing / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014774:Virulence / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D009569:Nitric Oxide; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP
keywords: Biofilm regulation; Nitric oxide; Quorum sensing; Regulación de biopelículas; cyclic di-GMP; di-GMPc; Óxido nítrico