title: The effect of anesthesia with propofol and sedation with butorphanol on quantitative contrast-enhanced ultrasonography of the healthy feline kidney.
abstract: Contrast-enhanced ultrasonography of the left kidney was performed using a commercial contrast agent in six healthy adult purpose-bred cats. A cross-over design was used to compare three protocols: (1) awake, (2) butorphanol (0.4 mg/kg IM), and (3) propofol (3.5-7.7 mg/kg IV boluses to effect). Time-intensity curves were created from two regions-of-interest drawn in the renal cortex. The curves were analyzed for blood flow parameters representing blood volume (base intensity, peak intensity, area-under-curve) and blood velocity (arrival time, time-to-peak, wash-in/out). There was no difference in the subjective enhancement pattern between the three protocols. No significant effect of butorphanol was observed in any of the perfusion parameters (P > 0.05). Propofol did not influence the most important perfusion parameter, area-under-the-curve, and is adequate for use in contrast-enhanced ultrasound studies.
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium. Electronic address: emmelie.stock@ugent.be.
authors.forename: Emmelie
authors.initials: E
authors.lastname: Stock
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Vanderperren
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Elke
authors.initials: E
authors.lastname: Van der Vekens
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Haers
authors.affiliation: Department of Comparative Physiology and Biometry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Duchateau
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Ingeborgh
authors.initials: I
authors.lastname: Polis
authors.affiliation: Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Myriam
authors.initials: M
authors.lastname: Hesta
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Jimmy H
authors.initials: JH
authors.lastname: Saunders
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002077:Butorphanol / Q000494:pharmacology*; D002415:Cats; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*; D014463:Ultrasonography
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D002077:Butorphanol; D015742:Propofol
keywords: Anesthesia; Cat; Contrast-enhanced ultrasonography; Kidney; Sedation