title: Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II.
abstract: Identifying chemicals, beyond those already implicated, to test for potential endocrine disruption is a challenge and high throughput approaches have emerged as a potential tool for this type of screening. This review focused the Environmental Protection Agency's (EPA) ToxCast(TM) high throughput in vitro screening (HTS) program. Utility for identifying compounds was assessed and reviewed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through the ToxPi(TM) prioritization scheme for endocrine disruption. The analysis included metabolic and neuroendocrine targets. This investigative approach simultaneously assessed the utility of ToxCast, and helped identify novel chemicals which may have endocrine activity. Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
authors.affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27709, USA.
authors.forename: Dayne
authors.initials: D
authors.lastname: Filer
authors.forename: Heather B
authors.initials: HB
authors.lastname: Patisaul
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Schug
authors.forename: David
authors.initials: D
authors.lastname: Reif
authors.forename: Kristina
authors.initials: K
authors.lastname: Thayer
mesh_terms: D000818:Animals; D016208:Databases, Factual; D052244:Endocrine Disruptors / Q000633:toxicity*; D057166:High-Throughput Screening Assays; D006801:Humans; D008962:Models, Theoretical; D018570:Risk Assessment; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D052244:Endocrine Disruptors