title: Aldosteronoma resolution score predicts long-term resolution of hypertension.
abstract: BACKGROUND
  The Aldosteronoma Resolution Score (ARS) takes into consideration four, readily available, preoperative clinical parameters in predicting the likelihood of resolution of hypertension in patients 6 months after undergoing unilateral adrenalectomy for aldosterone-producing adenoma (APA). We sought to determine the durability of this predictive model after 1 year.
  
  
  METHODS
  Sixty patients who underwent unilateral adrenalectomy for APA at a single institution between 2004 and 2013 were reviewed retrospectively. Patients who were normotensive without any antihypertensive medication requirement at greater than 1-year follow-up were considered to have complete resolution of hypertension.
  
  
  RESULTS
  Forty-seven patients had data available for analysis. Median follow-up was 1,135 days (371-3,202). Forty-five percent of patients had complete resolution, 45% had improvement, and 10% had no improvement in hypertension. Applying the ARS, we found there was complete resolution of hypertension in 73% of patients with ARS 4-5, 53% of patients with ARS 2-3, and 24% of patients with ARS 0-1 compared with 75% (P = .9), 46% (P = .66), and 28% (P = .76), respectively, in the original cohort used to create the ARS.
  
  
  CONCLUSIONS
  Most patients (90%) have long-term improvement or complete resolution of hypertension after unilateral adrenalectomy for APA. The ARS predicts accurately a patient's likelihood of complete resolution of hypertension beyond 1 year.
authors.affiliation: Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY.
authors.forename: Anna
authors.initials: A
authors.lastname: Aronova
authors.affiliation: Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Gordon
authors.affiliation: Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY.
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Finnerty
authors.affiliation: Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY.
authors.forename: Rasa
authors.initials: R
authors.lastname: Zarnegar
authors.affiliation: Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY. Electronic address: tjfahey@med.cornell.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Fahey
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D000328:Adult; D000450:Aldosterone / Q000032:analysis / Q000378:metabolism; D001795:Blood Pressure Determination; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis*; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000450:Aldosterone