title: Omeprazole does not modulate pharmacokinetic of digoxin in patients with heart failure.
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Felipe C
authors.initials: FC
authors.lastname: Souza
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Taiane M
authors.initials: TM
authors.lastname: Baptista
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Emiliana B
authors.initials: EB
authors.lastname: Marques
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Rogério B M
authors.initials: RB
authors.lastname: Barros
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil. Electronic address: christiannebretas@vm.uff.br.
authors.forename: Christianne B V
authors.initials: CB
authors.lastname: Scaramello
mesh_terms: D000328:Adult; D002316:Cardiotonic Agents / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004077:Digoxin / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004347:Drug Interactions / Q000502:physiology; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000097:blood* / Q000493:pharmacokinetics; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000097:blood* / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D002316:Cardiotonic Agents; D054328:Proton Pump Inhibitors; D004077:Digoxin; D009853:Omeprazole
keywords: Digoxin; Drug interactions; Omeprazole; P-glycoprotein; Pharmacokinetics; Toxicity