title: The dual nature of interleukin-10 in pemphigus vulgaris.
abstract: The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. Here we review the studies on IL-10 in pemphigus vulgaris and discuss the potential pathophysiological significance of these findings in comparison to prior studies of IL-10 in other human conditions. A better understanding of the complex roles of IL-10 in immune regulation may improve our understanding of pemphigus pathogenesis and treatment.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Michael Jeffrey
authors.initials: MJ
authors.lastname: Cho
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Christoph T
authors.initials: CT
authors.lastname: Ellebrecht
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: paynea@mail.med.upenn.edu.
authors.forename: Aimee S
authors.initials: AS
authors.lastname: Payne
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D016753:Interleukin-10 / Q000378:metabolism* / Q000627:therapeutic use; D008954:Models, Biological; D010392:Pemphigus / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*
chemical_list: D016753:Interleukin-10
keywords: Autoimmunity; Interleukin-10; Pemphigus