title: Myeloid cells in cancer-related inflammation.
abstract: Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines.
authors.affiliation: Humanitas Clinical and Research Center, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Caronni
authors.affiliation: Humanitas Clinical and Research Center, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy. Electronic address: benedetta.savino@humanitasresearch.it.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Savino
authors.affiliation: Humanitas Clinical and Research Center, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment
keywords: Cancer-related inflammation; Chemokine; Myeloid cells; Myeloid-derived suppressor cells; Tumor-associated macrophages; Tumor-associated neutrophils