title: Colchicine use in isolated renal AA amyloidosis.
abstract: We present the case of a 45-year-old woman, with two-year history of chronic renal insufficiency and proteinuria. A kidney biopsy showed the presence of AA amyloidosis (positive Congo red staining and immunohistochemistry). There was no evidence of amyloid deposits in other organs and there was no underlying disease. AA amyloidosis normally is secondary to chronic inflammatory or infectious diseases. High levels of IL-1, IL-6 and TNF-α play a role in the pathogenesis of amyloidosis and induce the synthesis of serum amyloid A protein (SAA), a precursor of tissue amyloid deposits. We empirically treated the patient with a low dose colchicine. The patient responded well. Colchicine has been used for the treatment of Familiar Mediterranean Fever and related auto-inflammatory diseases. To monitor treatment responses, we measured SAA finding low titers. Soon after treatment onset there were signs of improvement pertaining to proteinuria and stabilization of renal function.
authors.affiliation: Department of Rheumatology, Universitario Donostia, San Sebastián, Spain. Electronic address: carlosfrancisco.menesesvillalba@osakidetza.net.
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Meneses
authors.affiliation: Department of Rheumatology, Universitario Donostia, San Sebastián, Spain. Electronic address: cesarantonio.egueesdubuc@osakidetza.net.
authors.forename: César A
authors.initials: CA
authors.lastname: Egües
authors.affiliation: Department of Rheumatology, Universitario Donostia, San Sebastián, Spain. Electronic address: miren.uriarteecenarro@osakidetza.net.
authors.forename: Miren
authors.initials: M
authors.lastname: Uriarte
authors.affiliation: Department of Rheumatology, Universitario Donostia, San Sebastián, Spain. Electronic address: joaquinmaria.belzuneguiotano@osakidetza.net.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Belzunegui
authors.affiliation: Department of Pathology of Hospital, Universitario Donostia, San Sebastián, Spain. Electronic address: marta.rezolabajineta@osakidetza.net.
authors.forename: Marta
authors.initials: M
authors.lastname: Rezola
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy*; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine
keywords: Amiloidosis; Amyloidosis; Colchicina; Colchicine; Congo red; Proteína sérica amiloide A; Renal AA amiloidosis; Renal AA amyloidosis; Rojo congo; SAA; Serum A amyloid protein