title: Structural insights into the architecture of the hyperthermophilic Fusellovirus SSV1.
abstract: The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.
authors.affiliation: Center for Life in Extreme Environments, Biology Department, Portland State University, Portland, OR, USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Stedman
authors.affiliation: Center for Life in Extreme Environments, Biology Department, Portland State University, Portland, OR, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: DeYoung
authors.affiliation: Sealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Mitul
authors.initials: M
authors.lastname: Saha
authors.affiliation: Sealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Sherman
authors.affiliation: Sealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: mcmorais@utmb.edu.
authors.forename: Marc C
authors.initials: MC
authors.lastname: Morais
mesh_terms: D001105:Archaea / Q000821:virology; D003198:Computer Simulation; D020285:Cryoelectron Microscopy; D019143:Evolution, Molecular; D019241:Fuselloviridae / Q000235:genetics / Q000502:physiology / Q000648:ultrastructure*; D021621:Imaging, Three-Dimensional; D008958:Models, Molecular; D014771:Virion / Q000648:ultrastructure; D019065:Virus Assembly
keywords: Archaeal virus; Extremophile; Fullerene cone; Fusellovirus; Hyperthermophilic virus; SSV; SSV1; Spindle-shaped virus; Virus assembly; Virus structure