title: New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: a brief history.
abstract: Extra-virgin olive oil (EVOO), a principal component of the Mediterranean diet (Med diet), is one of the most ancient known foods and has long been associated with health benefits. Many phenolic compounds extracted from Olea europea L. have attracted attention since their discovery. Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseases, showing relevant pharmacological properties in various pathogenic processes, including inflammation, cancers and neurodegenerative diseases. Here, we discuss and summarize the most recent pharmacological evidence for the medical relevance of oleocanthal, focusing our attention on its anti-inflammatory and chemotherapeutic roles.
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain; Department of Molecular and Cellular Biology, University of A Coruña, A Coruña, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Abella
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Veronica
authors.initials: V
authors.lastname: Lopez
authors.affiliation: Servizo Galego de Saude, Division of Orthopaedics Surgery and Traumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pino
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Laboratory of Molecular and Cellular Cardiology, Research Laboratory 7, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA; Monell Chemical Senses Center, Philadelphia, PA, USA.
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
authors.affiliation: Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Division of Rheumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gómez-Reino
authors.affiliation: Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain. Electronic address: oreste.gualillo@sergas.es.
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D000447:Aldehydes / Q000266:history / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000266:history / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000266:history / Q000302:isolation & purification / Q000627:therapeutic use*; D000081004:Cyclopentane Monoterpenes; D005638:Fruit / Q000737:chemistry; D049674:History, 21st Century; D049690:History, Ancient; D006801:Humans; D031658:Olea / Q000737:chemistry*; D000069463:Olive Oil / Q000737:chemistry* / Q000266:history; D010636:Phenols / Q000266:history / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy / Q000266:history; D010946:Plants, Medicinal; D017365:Spices
chemical_list: D000447:Aldehydes; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000081004:Cyclopentane Monoterpenes; D000069463:Olive Oil; D010636:Phenols; C503534:oleocanthal