title: [Prevention of hypotension during spinal anesthesia for elective caesarean section: coloading with HAE 130/0.4 vs normal saline solution].
abstract: OBJECTIVE
  The aim of this study was to compare the efficacy of HES 130/0.4 coloading compared to normal saline solution for prevention of hypotension during spinal anesthesia for elective caesarean section.
  
  
  METHODS
  Prospective, randomized.
  
  
  METHODS
  One hundred and twenty ASA I and II patients scheduled for elective caesarean section were recruited. Patients were randomized to receive either 500mL of HES 130/0.4 (Voluven(®)) coloading (GroupV) or 500mL of normal saline solution coloading (GroupC). Spinal anesthesia technique and ephedrine administration were standardized in both groups. The primary endpoint was the incidence of maternal hypotension during spinal anesthesia for elective caesarean section.
  
  
  RESULTS
  Hypotension occurred in 43 patients in group C and 24 patients in group V (p=0.001). Ephedrine consumption was significantly lower in group V (P=0.005). Nausea, vomiting and headache incidence was higher in group C (p=0.006). Apgar scores and umbilical blood gazes were comparable between groups.
  
  
  CONCLUSIONS
  HES 130/0.4 coload was more effective than normal saline solution to prevent hypotension following spinal anesthesia for elective cesarean section. HES 130/0.4 coload reduced the incidence, the duration of longest hypotension, the need for ephedrine and the adverse maternal effects.
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Bennasr
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie. Electronic address: bmarzouksofiene@live.fr.
authors.forename: S
authors.initials: S
authors.lastname: Ben Marzouk
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: Z
authors.initials: Z
authors.lastname: Ajili
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Riahi
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: M A
authors.initials: MA
authors.lastname: Jarraya
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Massoudi
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Jabri
authors.affiliation: Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Maghrebi
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects / Q000379:methods*; D000775:Anesthesia, Spinal / Q000009:adverse effects / Q000379:methods*; D001034:Apgar Score; D001784:Blood Gas Analysis; D002585:Cesarean Section / Q000009:adverse effects / Q000379:methods*; D017558:Elective Surgical Procedures; D004809:Ephedrine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007022:Hypotension / Q000517:prevention & control*; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D014662:Vasoconstrictor Agents; D004809:Ephedrine
keywords: Caesarean section; Coload; Coremplissage; Césarienne; Hydroxyethylstarch; Hydroxyéthylamidon; Hypotension; Normal saline solution; Rachianesthésie; Spinal anesthesia; Sérum salé isotonique