title: Bioaccumulation of hydroxylated polychlorinated biphenyls and pentachlorophenol in the serum of northern elephant seal pups (Mirounga angustirostris).
abstract: Northern elephant seals (NES) (Mirounga angustirostris) from the Año Nuevo State Reserve (CA, USA) were sampled at 1-, 4-, 7- and 10-week post-weaning. Concentrations of hydroxylated polychlorinated biphenyls (HO-PCBs) and their parent PCBs were measured in the serum of each individual. The ΣHO-PCB concentrations in the serum increased significantly between early and late fast (from 282 ± 20 to 529 ± 31 pg/mL). This increase might result from a mobilisation of HO-PCBs transferred from the mother during gestation and/or lactation and stored in the pup's liver. Food deprivation has been shown to exacerbate biotransformation capacities in mammals, birds and fish. The HO-penta-CBs was the predominant homologue group, followed by HO-hexa-CBs and HO-hepta-CBs. No preferential pathway for the metabolism of HO-PCBs (HO-direct insertion or NIH-shift of a chlorine atom) could be evidenced. The concentrations of pentachlorophenol (PCP) in the serum of weaned NES increased from 103 ± 7 pg/mL at early fast to 246 ± 41 pg/mL at late fast, which is within the range of PCP concentrations usually encountered in marine mammals.
authors.affiliation: Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve, Belgium. Electronic address: caroline.louis@uclouvain.be.
authors.forename: Caroline
authors.initials: C
authors.lastname: Louis
authors.affiliation: Department of Pharmaceutical Sciences, Toxicological Center, Campus Drie Eiken, Universiteit Antwerpen, Universiteitsplein 1, 2610 Wilrijk, Belgium.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covaci
authors.affiliation: Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Stas
authors.affiliation: Department of Biology, Sonoma State University, 1801 East Cotati Ave, Rohnert Park, CA 94928, USA.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Crocker
authors.affiliation: Department of Pharmaceutical Sciences, Toxicological Center, Campus Drie Eiken, Universiteit Antwerpen, Universiteitsplein 1, 2610 Wilrijk, Belgium.
authors.forename: Govindan
authors.initials: G
authors.lastname: Malarvannan
authors.affiliation: Department of Pharmaceutical Sciences, Toxicological Center, Campus Drie Eiken, Universiteit Antwerpen, Universiteitsplein 1, 2610 Wilrijk, Belgium; Department of Chemistry, "Al. I. Cuza" University of Iasi, 700506 Iasi, Romania.
authors.forename: Alin C
authors.initials: AC
authors.lastname: Dirtu
authors.affiliation: Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Cathy
authors.initials: C
authors.lastname: Debier
mesh_terms: D000818:Animals; D006900:Hydroxylation; D010416:Pentachlorophenol / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D046048:Seals, Earless / Q000097:blood*
chemical_list: D010416:Pentachlorophenol; D011078:Polychlorinated Biphenyls
keywords: Fast; HO-PCBs; Northern elephant seal; Pentachlorophenol; Pup; Serum