title: Successful lung transplantation after donor lung reconditioning with urokinase in ex vivo lung perfusion system.
abstract: Acute pulmonary embolism is considered a contraindication to lung donation for transplantation as it might result in graft dysfunction. Ex vivo lung perfusion (EVLP) is a novel method to assess and recondition a questionable donor graft before transplantation. In this report we present a case of successful bilateral lung transplant after donor lung assessment and treatment with a fibrinolytic agent, urokinase, during EVLP.
authors.affiliation: Department of Thoracic Surgery, University Hospital, Zurich, Switzerland. Electronic address: ilhan.inci@usz.ch.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Inci
authors.affiliation: Department of Thoracic Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Department of Thoracic Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Sven
authors.initials: S
authors.lastname: Hillinger
authors.affiliation: Department of Thoracic Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jungraithmayr
authors.affiliation: Department of Cardiovascular Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Trinkwitz
authors.affiliation: Department of Thoracic Surgery, University Hospital, Zurich, Switzerland.
authors.forename: Walter
authors.initials: W
authors.lastname: Weder
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000601:surgery*; D004867:Equipment Design; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015424:Reperfusion / Q000295:instrumentation*; D014019:Tissue Donors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
chemical_list: D014568:Urokinase-Type Plasminogen Activator