title: Could physical exercises modulate Nrf2-Keap1 pathway in chronic kidney disease?
abstract: Patients with chronic kidney disease (CKD) have various metabolic disorders caused by a chronic state of oxidative stress and inflammation, and recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a factor that plays a significant role in cellular protection against oxidative stress and inflammation. This transcription factor when activated can regulate antioxidant and anti-inflammatory cellular responses leading to the expression of detoxifying enzymes. Studies have shown that Nrf2 expression can be modulated by several factors, such as bioactive compounds and physical exercise. In fact, exercise in CKD patients can bring many benefits; however, there are no studies correlating physical activity and Nrf2 expression in CKD patients. This review aims to discuss whether there is any evidence to justify a recommendation of physical exercise in CKD patients as a non-pharmacological option to activate the Nrf2 pathway.
authors.affiliation: Graduate Program in Cardiovascular Sciences, Federal Fluminense University (UFF), Niteroi, Brazil. Electronic address: cinthia_costa@id.uff.br.
authors.forename: C C
authors.initials: CC
authors.lastname: Abreu
authors.affiliation: Graduate Program in Cardiovascular Sciences, Federal Fluminense University (UFF), Niteroi, Brazil.
authors.forename: L F M F
authors.initials: LF
authors.lastname: Cardozo
authors.affiliation: Graduate Program in Cardiovascular Sciences, Federal Fluminense University (UFF), Niteroi, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Mafra
mesh_terms: D015444:Exercise / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D000072019:Kelch-Like ECH-Associated Protein 1; D008954:Models, Biological; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human