title: Quantitative assessment of the influence of glutathione S-transferase M1 null variant on ovarian cancer risk.
abstract: OBJECTIVE
  Many studies have reported the role of glutathione S-transferase Mu 1 (GST M1) polymorphism with ovary cancer risk, but the results remained controversial.
  
  
  METHODS
  To derive a more precise estimation of the relationship, a meta-analysis was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between GSTM1 polymorphism and ovary cancer risk. A total of 11 studies including 2709 cases and 3599 controls were also involved in this meta-analysis.
  
  
  RESULTS
  When all the eligible studies were pooled into this meta-analysis, no significant association between ovary cancer risk and GSTM1 polymorphism was found (OR = 1.010, 95% CI = 0.911-1.121, P heterogeneity = 0.174, P = 0.848).
  
  
  CONCLUSIONS
  Our meta-analysis supports that the GSTM1 polymorphism is not contributed to the risk of ovary cancer from currently available evidence.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Shuo
authors.initials: S
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: You
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China.
authors.forename: Xipeng
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D005982:Glutathione Transferase