title: Mesoporous silica nanoparticles in drug delivery and biomedical applications.
abstract: In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration.
  
  
  BACKGROUND
  This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Qinfu
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Han
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Erxi
authors.initials: E
authors.lastname: Che
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
authors.forename: Tongying
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China. Electronic address: silingwang@syphu.edu.cn.
authors.forename: Siling
authors.initials: S
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide
keywords: Biocompatibility; Biomedical applications; Drug delivery systems; Mesoporous silica nanoparticles