title: Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase.
abstract: Phenolic extracts from 20 Canadian lentil cultivars (Lens culinaris) were evaluated for total phenolic contents and composition, antioxidant activities (DPPH, FRAP, ORAC), and inhibitory properties against α-glucosidase and pancreatic lipase. Twenty one phenolic compounds were identified in the present study, with the majority being flavonoids, including kaempeferol glycosides, catechin/epicatechin glucosides and procyanidins. These phenolic compounds not only contributed significantly to the antioxidant activities, but they were also good inhibitors of α-glucosidase and lipase, two enzymes, respectively, associated with glucose and lipid digestion in the human intestine, thus contributing significantly to the control of blood glucose levels and obesity. More interestingly, it was the flavonols, not the flavanols, which showed the inhibitory activities against α-glucosidase and pancreatic lipase. Our result provides supporting information for developing lentil cultivars and functional foods with improved health benefits and suggests a potential role of lentil consumption in managing weight and control of blood glucose.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: zeyuandeng@hotmail.com.
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada.
authors.forename: D Dan
authors.initials: DD
authors.lastname: Ramdath
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada; Key Laboratory of Food Nutrition & Safety (Tianjin University of Science & Technology), Ministry of Education, Tianjin 300457, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada; Department of Food Science, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Chen
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, Canada. Electronic address: rong.cao@agr.gc.ca.
authors.forename: Rong
authors.initials: R
authors.lastname: Tsao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002170:Canada; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000032:analysis; D055951:Functional Food / Q000032:analysis; D006801:Humans; D027806:Lens Plant / Q000737:chemistry* / Q000145:classification; D008049:Lipase / Q000032:analysis / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D051381:Rats; D013552:Swine; D000520:alpha-Glucosidases / Q000032:analysis
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D008049:Lipase; D000520:alpha-Glucosidases
keywords: Antioxidant activities; Diabetes; Lentils; Lipase; Phenolics; Weight loss; α-Glucosidase