title: Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations.
abstract: We study the stationary state of a population evolving under the action of random genetic drift, selection and recombination in which both deleterious and reverse beneficial mutations can occur. We find that the equilibrium fraction of deleterious mutations decreases as the population size is increased. We calculate exactly the steady state frequency in a nonrecombining population when population size is infinite and for a neutral finite population, and obtain bounds on the fraction of deleterious mutations. We also find that for small and very large populations, the number of deleterious mutations depends weakly on recombination, but for moderately large populations, recombination alleviates the effect of deleterious mutations. An analytical argument shows that recombination decreases disadvantageous mutations appreciably when beneficial mutations are rare as is the case in adapting microbial populations, whereas it has a moderate effect on codon bias where the mutation rates between the preferred and unpreferred codons are comparable.
authors.affiliation: Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore 560064, India. Electronic address: sonajohn@jncasr.ac.in.
authors.forename: Sona
authors.initials: S
authors.lastname: John
authors.affiliation: Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore 560064, India. Electronic address: jain@jncasr.ac.in.
authors.forename: Kavita
authors.initials: K
authors.lastname: Jain
mesh_terms: D040961:Genetic Drift; D009154:Mutation / Q000235:genetics*; D059645:Mutation Rate; D011156:Population Density; D011995:Recombination, Genetic; D012641:Selection, Genetic
keywords: Back mutations; Finite population; Linkage