title: A virus that can take the heat.
abstract: Foot-and-mouth disease virus shows remarkable thermal lability, a property that is a particular problem for vaccine preparations. In this issue of Structure, Rincón and colleagues show that electrostatic repulsion within the capsid is responsible for this lability, and they present rationally designed mutants with increased thermostability.
authors.affiliation: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
authors.forename: Elin M
authors.initials: EM
authors.lastname: Sivertsson
authors.affiliation: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. Electronic address: lsi10@cam.ac.uk.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Itzhaki
mesh_terms: D036022:Capsid Proteins / Q000737:chemistry*; D029544:Foot-and-Mouth Disease Virus / Q000502:physiology*; D012367:RNA, Viral / Q000235:genetics*; D014765:Viral Vaccines / Q000737:chemistry*; D014771:Virion / Q000737:chemistry*
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral; D014765:Viral Vaccines