title: Altered default mode network functional connectivity in schizotypal personality disorder.
abstract: The default mode network (DMN) has been identified to play a critical role in many mental disorders, but such abnormalities have not yet been determined in patients with schizotypal personality disorder (SPD). The purpose of this study was to analyze the alteration of the DMN functional connectivity in subjects with (SPD) and compared it to healthy control subjects. Eighteen DSM-IV diagnosed SPD subjects (all male, average age: 19.7±0.9) from a pool of 3000 first year college students, and eighteen age and gender matched healthy control subjects were recruited (all male, average age: 20.3±0.9). Independent component analysis (ICA) was used to analyze the DMN functional connectivity alteration. Compared to the healthy control group, SPD subjects had significantly decreased functional connectivity in the frontal areas, including the superior and medial frontal gyrus, and greater functional connectivity in the bilateral superior temporal gyrus and sub-lobar regions, including the bilateral putamen and caudate. Compared to subjects with SPD, the healthy control group showed decreased functional connectivity in the bilateral posterior cingulate gyrus, but showed greater functional connectivity in the right transverse temporal gyrus and left middle temporal gyrus. The healthy control group also showed greater activation in the cerebellum compared to the SPD group. These findings suggest that DMN functional connectivity, particularly that involving cognitive or emotional regulation, is altered in SPD subjects, and thus may be helpful in studying schizophrenia.
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China; Tianjin Medical University, Tianjin, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China; Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region.
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China; Tianjin Medical University, Tianjin, China. Electronic address: cjr.wujianlin@vip.163.com.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region.
authors.forename: Wutao
authors.initials: W
authors.lastname: Lou
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region; Department of Biomedical Engineering and Shun Hing Institute of Advanced Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China. Electronic address: dfwang@cuhk.edu.hk.
authors.forename: Defeng
authors.initials: D
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: Default mode network; Functional connectivity; MRI; Schizotypal personality disorder