title: The effect of resveratrol on the recurrent attacks of gouty arthritis.
abstract: Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration. The management of gout, especially the recurrent acute attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effect of resveratrol on gouty arthritis. MSU was used to induce gouty arthritis in the foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneal injected to the mice in the treatment group. The pad inflammation and the level of serum uric acid were investigated to estimate the effect of resveratrol in gouty arthritis. Hyperuricemia was significantly detected in the mice treated with yeast polysaccharide and potassium oxonate, and gouty arthritis was successfully induced with MSU in mice. We further identified that resveratrol inhibited pad swelling and pad 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent acute attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.|Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.|Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.|Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.
authors.forename: Shucong
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Division of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, 200040.
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, 200040.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.|Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02129, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.|Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.
authors.forename: Hejian
authors.initials: H
authors.lastname: Zou
authors.affiliation: Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040. pp056@hotmail.com.|Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040. pp056@hotmail.com.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D015210:Arthritis, Gouty / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012008:Recurrence; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood
chemical_list: D013267:Stilbenes; D014527:Uric Acid; D000077185:Resveratrol
keywords: Arthritis; Gout; Hyperuricemia; Resveratrol; Sirt1