title: Biocompatible long-sustained release oil-core polyelectrolyte nanocarriers: From controlling physical state and stability to biological impact.
abstract: It has been generally expected that the most applicable drug delivery system (DDS) should be biodegradable, biocompatible and with incidental adverse effects. Among many micellar aggregates and their mediated polymeric systems, polyelectrolyte oil-core nanocarriers have been found to successfully encapsulate hydrophobic drugs in order to target cells and avoid drug degradation and toxicity as well as to improve drug efficacy, its stability, and better intracellular penetration. This paper reviews recent developments in the formation of polyelectrolyte oil-core nanocarriers by subsequent multilayer adsorption at micellar structures, their imaging, physical state and stability, drug encapsulation and applications, in vitro release profiles and in vitro biological evaluation (cellular uptake and internalization, biocompatibility). We summarize the recent results concerning polyelectrolyte/surfactant interactions at interfaces, fundamental to understand the mechanisms of formation of stable polyelectrolyte layered structures on liquid cores. The fabrication of emulsion droplets stabilized by synergetic surfactant/polyelectrolyte complexes, properties, and potential applications of each type of polyelectrolyte oil-core nanocarriers, including stealth nanocapsules with pegylated shell, are discussed and evaluated.
authors.affiliation: J. Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szczepanowicz
authors.affiliation: Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Bazylińska
authors.affiliation: Department of Medical Biochemistry, Medical University, Chałubińskiego 10, 50-368 Wrocław, Poland.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Pietkiewicz
authors.affiliation: J. Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.
authors.forename: Lilianna
authors.initials: L
authors.lastname: Szyk-Warszyńska
authors.affiliation: Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. Electronic address: kazimiera.wilk@pwr.edu.pl.
authors.forename: Kazimiera A
authors.initials: KA
authors.lastname: Wilk
authors.affiliation: J. Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland. Electronic address: ncwarszy@cyf-kr.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Warszyński
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004573:Electrolytes / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D009821:Oils / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004573:Electrolytes; D009821:Oils; D011108:Polymers
keywords: Biocompatibility; Cytotoxicity; Encapsulation; Layer-by-layer; Nanoemulsion-templated nanocapsules; Release profiles