title: Assisted reproductive technologies in Latin America: the Latin American Registry, 2012.
abstract: Multinational data on assisted reproduction technologies were collected from 155 institutions in 14 Latin American countries during 2012. Case-by-case data included 47,326 assisted reproduction technology cycles covering over 80% of cycles carried out in Latin America. Treatments included IVF, intracytoplasmic sperm injection (ICSI), frozen embryo transfers, oocyte donations and fertility preservation. Embryo transfer and IVF-ICSI was carried out in 39% of women aged 35-39 years and 31% of women aged 40 years or over. Delivery rate per oocyte retrieval was 20.9% for ICSI and 26.5% for IVF. Multiple births comprised 20.6% twins and 1.2% triplets and over. In oocyte donations, twins reached 27.8% and triplets and over 2.4%. Pre-term births in singletons were 14%. The relative risk of prematurity increased by 4.30 (95% CI 4.1 to 4.6) in twins and 43.8 (95% CI 28.5 to 67.4) in triplets and higher. Perinatal mortality increased from 25.2 per thousand in singletons to 44.4 in twins and 80.7 in triplets and over. Elective single embryo transfer was carried out in only 1.4%, of cycles, with a delivery rate of 30% in women 34 years or younger, and should be considered the way forward provided access is facilitated with public funding.
authors.affiliation: Unit of Reproductive Medicine, Clínica las Condes, Lo Fontecilla 4412, Santiago, Chile; Program of Ethics and Public Policies in Human Reproduction, University Diego Portales, Ejercito 260, Santiago, Chile. Electronic address: fzegers@clc.cl.
authors.forename: Fernando
authors.initials: F
authors.lastname: Zegers-Hochschild
authors.affiliation: Clínica Monteblanco, Camino a Farellones 17780, Santiago, Chile.
authors.forename: Juan Enrique
authors.initials: JE
authors.lastname: Schwarze
authors.affiliation: Unit of Reproductive Medicine, Clínica las Condes, Lo Fontecilla 4412, Santiago, Chile.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Crosby
authors.affiliation: Unit of Reproductive Medicine, Clínica las Condes, Lo Fontecilla 4412, Santiago, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Musri
authors.affiliation: Fertipraxis- Centro de Reprodução Humana, Av. das Américas, 4.666 grupos 312/313, Rio de Janeiro, Brasil.
authors.forename: Maria
authors.initials: M
authors.lastname: do Carmo Borges de Souza
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D006801:Humans; D007843:Latin America; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D012042:Registries; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data; D014310:Triplets; D014427:Twins
keywords: IVF; Latin America; assisted reproductive technologies; epidemiology; multiple births; outcomes; registry