title: Obesity-related kidney disease.
abstract: The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.
authors.affiliation: Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL 33328, USA. Electronic address: snyderdo@nova.edu.
authors.forename: Samuel
authors.initials: S
authors.lastname: Snyder
authors.affiliation: 2150 SE Salerno Rd, Suite 200, Stuart, FL 34997, USA.
authors.forename: Gracie A
authors.initials: GA
authors.lastname: Turner
authors.affiliation: 200 SE, Hospital Ave. Stuart, FL 34994, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Turner
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000367:Age Factors; D001786:Blood Glucose; D016207:Cytokines / Q000378:metabolism; D050171:Dyslipidemias / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D015438:Health Behavior; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007249:Inflammation / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D008019:Life Style; D009765:Obesity / Q000453:epidemiology* / Q000503:physiopathology*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors; D012737:Sex Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014481:United States / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D016207:Cytokines
keywords: Hypertension; Inflammation; Insulin resistance; Kidney; Obesity