title: Chikungunya, a paradigm of neglected tropical disease that emerged to be a new health global risk.
abstract: Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family that causes chronic and incapacitating arthralgia in human populations. Since its discovery in 1952, CHIKV was responsible for sporadic and infrequent outbreaks. However, since 2005, global Chikungunya outbreaks have occurred, inducing some fatalities and associated with severe and chronic morbidity. Chikungunya is thus considered as an important re-emerging public health problem in both tropical and temperate countries, where the distribution of the Aedes mosquito vectors continues to expand. This review highlights the most recent advances in our knowledge and understanding of the epidemiology, biology, treatment and vaccination strategies of CHIKV.
authors.affiliation: Centre International de Recherches Médicales de Franceville, Franceville, Gabon; Unité Mixte de Recherche Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (IRD 224 - CNRS 5290 - UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Rougeron
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Sam
authors.affiliation: Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Caron
authors.affiliation: Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Nkoghe
authors.affiliation: Centre International de Recherches Médicales de Franceville, Franceville, Gabon; Unité Mixte de Recherche Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (IRD 224 - CNRS 5290 - UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Leroy
authors.affiliation: CEA, Institute of Emerging Diseases and Innovative Therapies, Division of Immuno-Virology, Fontenay-aux-Roses, France; Université Paris-Sud 11, UMR E1, Orsay, France. Electronic address: pierre.roques@cea.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Roques
mesh_terms: D000330:Aedes / Q000821:virology*; D000349:Africa / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D065632:Chikungunya Fever / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D002646:Chikungunya virus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D021821:Communicable Diseases, Emerging; D004196:Disease Outbreaks; D014943:Global Health; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D058069:Neglected Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D014611:Vaccination; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines
keywords: Chikungunya