title: Seizure prevention by the naturally occurring phenols, carvacrol  and thymol in a partial seizure-psychomotor model.
abstract: The natural compounds carvacrol and thymol completely prevented seizures in the 6 Hz, 32 mA partial seizure model. Carvacrol and thymol, both exhibited an ED₅₀ = 35.8 mg/kg, ip and yielded protective indices of 5.3 and 3.4, respectively. At 44 mA current intensity, carvacrol and thymol exhibited ED₅₀s of 88.82 mg/kg (PI = 2.15) and 73.0 mg/kg (PI = 1.65), respectively. Thymol, but not carvacrol showed partial inhibitory activity in the maximal electroshock (MES), sc Metrazol (scMET) and Corneal-kindled models. These results suggest that carvacrol and thymol are more efficacious anticonvulsants than suggested by their lower efficacies in the conventional MES and scMET tests.
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Mishra
authors.forename: Max T
authors.initials: MT
authors.lastname: Baker
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D000081007:Cymenes; D004195:Disease Models, Animal; D039821:Monoterpenes / Q000627:therapeutic use*; D010636:Phenols / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D012640:Seizures / Q000517:prevention & control*; D013943:Thymol / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D000081007:Cymenes; D039821:Monoterpenes; D010636:Phenols; D013943:Thymol; C073316:carvacrol