title: One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties.
abstract: A one-pot environmentally friendly transamidation of ω-3 fatty acid ethyl esters to amides and mono- or diacylglycerols was investigated via the use of a polymer-supported lipase. The method was used to synthesize a library of fatty acid monoglyceryl esters and amides. These new derivatives were found to have potent growth inhibition effects against A549 lung cancer cells.
authors.affiliation: Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, Canada.
authors.forename: Hugo
authors.initials: H
authors.lastname: Tremblay
authors.affiliation: Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: St-Georges
authors.affiliation: Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, Canada.
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Legault
authors.affiliation: SCF Pharma, Ste Luce (Qc) G0K 1P0, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Morin
authors.affiliation: SCF Pharma, Ste Luce (Qc) G0K 1P0, Canada.
authors.forename: Samuel
authors.initials: S
authors.lastname: Fortin
authors.affiliation: Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Marsault
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D004952:Esters; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004800:Enzymes, Immobilized; D004952:Esters; D005231:Fatty Acids, Unsaturated; D008049:Lipase
keywords: Environmentally friendly synthesis; Growth inhibition; Polyunsaturated fatty acid amides; Transamidation