title: Applications of biomaterials in corneal wound healing.
abstract: Disease affecting the cornea is a common cause of blindness worldwide. To date, the amniotic membrane (AM) is the most widely used clinical method for cornea regeneration. However, donor-dependent differences in the AM may result in variable clinical outcomes. To overcome this issue, biomaterials are currently under investigation for corneal regeneration in vitro and in vivo. In this article, we highlight the recent advances in hydrogels, bioengineered prosthetic devices, contact lenses, and drug delivery systems for corneal regeneration. In clinical studies, the therapeutic effects of biomaterials, including fibrin and collagen-based hydrogels and silicone contact lenses, have been demonstrated in damaged cornea. The combination of cells and biomaterials may provide potential treatment in corneal wound healing in the future.
authors.affiliation: Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan, ROC.
authors.forename: I-Lun
authors.initials: IL
authors.lastname: Tsai
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: Chih-Chien
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Division of Ophthalmology, National Yang-Ming University Hospital, I-Lan, Taiwan, ROC.
authors.forename: Kuo-Hsuan
authors.initials: KH
authors.lastname: Hung
authors.affiliation: School of Nursing, College of Medicine, Chang-Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chi-Wen
authors.initials: CW
authors.lastname: Chang
authors.affiliation: Department of Education and Research, Taipei City Hospital, Taipei, Taiwan, ROC; Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: chengyunghsin@gmail.com.
authors.forename: Yung-Hsin
authors.initials: YH
authors.lastname: Cheng
mesh_terms: D000650:Amnion / Q000502:physiology; D001672:Biocompatible Materials / Q000627:therapeutic use*; D057005:Bioengineering; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000502:physiology*; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000627:therapeutic use; D010390:Pemphigoid, Benign Mucous Membrane / Q000209:etiology; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels
keywords: bioengineered prosthetic devices; biomaterials; contact lenses; corneal regeneration; hydrogels