title: The Cancer Genomics Resource List 2014.
abstract: BACKGROUND
  Genomic sequencing for cancer is offered by commercial for-profit laboratories, independent laboratory networks, and laboratories in academic medical centers and integrated health networks. The variability among the tests has created a complex, confusing environment.
  
  
  OBJECTIVE
  To address the complexity, the Personalized Health Care (PHC) Committee of the College of American Pathologists proposed the development of a cancer genomics resource list (CGRL). The goal of this resource was to assist the laboratory pathology and clinical oncology communities.
  
  
  METHODS
  The PHC Committee established a working group in 2012 to address this goal. The group consisted of site-specific experts in cancer genetic sequencing. The group identified current next-generation sequencing (NGS)-based cancer tests and compiled them into a usable resource. The genes were annotated by the working group. The annotation process drew on published knowledge, including public databases and the medical literature.
  
  
  RESULTS
  The compiled list includes NGS panels offered by 19 laboratories or vendors, accompanied by annotations. The list has 611 different genes for which NGS-based mutation testing is offered. Surprisingly, of these 611 genes, 0 genes were listed in every panel, 43 genes were listed in 4 panels, and 54 genes were listed in 3 panels. In addition, tests for 393 genes were offered by only 1 or 2 institutions. Table 1 provides an example of gene mutations offered for breast cancer genomic testing with the annotation as it appears in the CGRL 2014.
  
  
  CONCLUSIONS
  The final product, referred to as the Cancer Genomics Resource List 2014, is available as supplemental digital content.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Zutter
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Bloom
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Ian S
authors.initials: IS
authors.lastname: Hagemann
authors.forename: Jill H
authors.initials: JH
authors.lastname: Kaufman
authors.forename: Alyssa M
authors.initials: AM
authors.lastname: Krasinskas
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Lazar
authors.forename: Debra G B
authors.initials: DG
authors.lastname: Leonard
authors.forename: Neal I
authors.initials: NI
authors.lastname: Lindeman
authors.forename: Ann M
authors.initials: AM
authors.lastname: Moyer
authors.forename: Marina N
authors.initials: MN
authors.lastname: Nikiforova
authors.forename: Jan A
authors.initials: JA
authors.lastname: Nowak
authors.forename: John D
authors.initials: JD
authors.lastname: Pfeifer
authors.forename: Antonia R
authors.initials: AR
authors.lastname: Sepulveda
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Willis
authors.affiliation: From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee (Dr Zutter); the Department of Pathology, Clarient Diagnostic Services, Aliso Viejo, California (Dr Bloom); the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis (Dr Cheng); the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri (Drs Hagemann and Pfeifer); Surveys, College of American Pathologists, Northfield, Illinois (Dr Kaufman); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Krasinskas); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology and Laboratory Medicine, Fletcher Allen Health Care, Burlington, Vermont (Dr Leonard); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the Department of Pathology, Mayo Clinic, Rochester, Minnesota (Dr Moyer); Molecular and Genomic Pathology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Nikiforova); the Department of Pathology, NorthShore University Health System, Evanston, Illinois (Dr Nowak); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Sepulveda); the Department of Pathology, Case Medical Center/Case Western Reserve University, Cleveland, Ohio (Dr Willis); and the Department of Molecular Pathology and Hematopathology, University of Minnesota, Minneapolis (Dr Yohe).
authors.forename: Sophia L
authors.initials: SL
authors.lastname: Yohe
mesh_terms: D016208:Databases, Factual; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D057089:Pathology, Molecular / Q000592:standards