title: Integrating systemic and surgical approaches to treating metastatic colorectal cancer.
abstract: Multiple new treatment options for metastatic colorectal cancer have been developed over the past 2 decades, including conventional chemotherapy and agents directed against vascular endothelial growth factor and epidermal growth factor receptor. Combination regimens, integrated with surgical approaches, have led to an increase in median survival, and a minority of patients with resectable disease can survive for years. Clinical decision-making therefore requires a strategic, biomarker-based multidisciplinary approach to maximize life expectancy and quality of life. This review describes systemic approaches to the treatment of patients with metastatic colorectal cancer, including integration with liver resection, other liver-directed therapies, and primary resection.
authors.affiliation: Taussig Cancer Institute, Department of Hematology and Oncology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Kaihong
authors.initials: K
authors.lastname: Mi
authors.affiliation: Taussig Cancer Institute, Department of Hematology and Oncology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Digestive Disease Institute, Department of Colorectal Surgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Kalady
authors.affiliation: Digestive Disease Institute, HPB and Liver Transplant Program, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Quintini
authors.affiliation: Taussig Cancer Institute, Department of Hematology and Oncology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: Khorana@ccf.org.
authors.forename: Alok A
authors.initials: AA
authors.lastname: Khorana
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents
keywords: Antiangiogenic therapy; Antineoplastic therapy; Colorectal cancer; Liver metastases; Liver-directed therapy