title: Effects of lazaroid U-74389G on intestinal ischemia and reperfusion injury in porcine experimental model.
abstract: BACKGROUND
  The readmission of molecular oxygen into an ischemic tissue promotes the oxidation of resuscitated tissue with certain pathophysiologic mechanisms.
  
  
  METHODS
  Twenty four pigs (male or female) were randomized in this study. The animals were allocated to four groups with an equal number (n = 6) in each group: (1) control group-ischemia for 30 min and reperfusion for 60 min. (2) control group-ischemia for 30 min and reperfusion for 120 min. (3) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 60 min. (4) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 120 min.
  
  
  RESULTS
  We investigated further the role of an antioxidant molecule such as U-74389G and we concluded that there is statistically significant relation in MDA (malondialdeyde), TNF -α (tumor necrosis factor-α) measurement in tissue, while the histological score in the groups that the lazaroid was administered was improved.
  
  
  CONCLUSIONS
  In many emergency clinical situations, such as reperfusion of the intestine, the role of U-74389G can be protective.
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece. Electronic address: iflessas@gmail.com.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Flessas
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Bramis
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Menenakos
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.affiliation: Department of Pathology, School of Medicine, University of Athens, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.affiliation: Department of Pathology, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.affiliation: Department of Pathology, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Afroditi
authors.initials: A
authors.lastname: Nonni
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Chrysikos
authors.affiliation: Department of Surgery, Red Cross Hospital, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Korontzi
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Greece.
authors.forename: Aristea
authors.initials: A
authors.lastname: Gioxari
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Zografos
authors.affiliation: Experimental-Research Center, Elpen Pharmaceuticals, Athens, Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008962:Models, Theoretical; D011281:Pregnatrienes / Q000494:pharmacology / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D013552:Swine; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000975:Antioxidants; D011281:Pregnatrienes; D014409:Tumor Necrosis Factor-alpha; C074965:U 74389F; D008315:Malondialdehyde
keywords: Intestinal ischemia; Lazaroid; Reperfusion injury; U-74389G