title: Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir.
abstract: A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5×10(-6)-1.0×10(-3)M with a limit of detection at 7.5×10(-7)M. Finally, the developed MIP-voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo, Cairo, Egypt.
authors.forename: Nesrine Abdelrehim
authors.initials: NA
authors.lastname: El Gohary
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Adel
authors.initials: A
authors.lastname: Madbouly
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo, Cairo, Egypt; Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: rasha.elnashar@guc.edu.eg.
authors.forename: Rasha Mohamed
authors.initials: RM
authors.lastname: El Nashar
authors.affiliation: Institute of Analytical and Bioanalytical Chemistry, University of Ulm, 89081 Ulm, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Mizaikoff
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000032:analysis; D000998:Antiviral Agents / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D000077595:Famciclovir; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008958:Models, Molecular; D054802:Molecular Imprinting; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D011108:Polymers; D015075:2-Aminopurine; D002244:Carbon; D000077595:Famciclovir
keywords: Carbon paste electrode; Computational studies; Famciclovir; MIPs; Molecular imprinted polymers; and cyclic voltammetry