title: Analysis of blood leukocytes in a naturally occurring immunodeficiency of pigs shows the defect is localized to B and T cells.
abstract: Severe combined immunodeficiency (SCID) is the result of a set of inherited genetic defects which render components of the immune response nonfunctional. In Arabian horses, Jack Russell terriers, and mice, the disorder is a consequence of the absence of T and B lymphocytes, while natural killer (NK) cell and other leukocyte populations remain intact. Preliminary analysis of a naturally acquired form of inherited SCID in a line of pigs showed several defects in the architecture and composition of secondary lymphoid organs. In this study, a quantitative assessment of lymphocyte populations in affected and normal littermates showed depleted T or B lymphocyte populations in affected pigs; however, NK cells and neutrophils were present in numbers comparable to unaffected littermates. The results indicate that the immune defect in pigs shares the same features as other SCID-affected species.
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
authors.forename: C L
authors.initials: CL
authors.lastname: Ewen
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
authors.forename: A G
authors.initials: AG
authors.lastname: Cino-Ozuna
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
authors.forename: H
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
authors.forename: M A
authors.initials: MA
authors.lastname: Kerrigan
authors.affiliation: Department of Animal Science, Iowa State University, Ames, IA 50011, United States.
authors.forename: J C M
authors.initials: JC
authors.lastname: Dekkers
authors.affiliation: Department of Animal Science, Iowa State University, Ames, IA 50011, United States.
authors.forename: C K
authors.initials: CK
authors.lastname: Tuggle
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
authors.forename: R R R
authors.initials: RR
authors.lastname: Rowland
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States. Electronic address: cwyatt@vet.k-state.edu.
authors.forename: C R
authors.initials: CR
authors.lastname: Wyatt
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006651:Histocytochemistry / Q000662:veterinary; D018655:Lymphocyte Count / Q000662:veterinary; D008221:Lymphoid Tissue / Q000276:immunology*; D016511:Severe Combined Immunodeficiency / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
keywords: Lymphocytes; Severe combined immunodeficiency; Swine