title: Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.
abstract: There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Although these exacerbations are associated with several types of viruses, human rhinoviruses (HRVs) are associated with the vast majority of disease exacerbations. Due to the lack of an animal species that is naturally permissive for HRVs to use as a facile model system, and the limitations associated with animal models of asthma and COPD, studies of controlled experimental infection of humans with HRVs have been used and conducted safely for decades. This review discusses how these experimental infection studies with HRVs have provided a means of understanding the pathophysiology underlying virus-induced exacerbations of asthma and COPD with the goal of developing agents for their prevention and treatment.
authors.affiliation: Janssen Research and Development, Immunology Clinical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA.
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Del Vecchio
authors.affiliation: Janssen Research and Development, Immunology Clinical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Branigan
authors.affiliation: Janssen Research and Development, Immunology Clinical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA.
authors.forename: Elliot S
authors.initials: ES
authors.lastname: Barnathan
authors.affiliation: Janssen Research and Development, Immunology Clinical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Flavin
authors.affiliation: Janssen Research and Development, Immunology Clinical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA. Electronic address: PSilkoff@its.jnj.com.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Silkoff
authors.affiliation: University of Virginia, School of Medicine, Charlottesville, VA 22908, USA.
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Turner
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology / Q000821:virology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D010850:Picornaviridae Infections / Q000503:physiopathology / Q000821:virology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000821:virology*; D012229:Rhinovirus / Q000302:isolation & purification*
keywords: Asthma; Chronic obstructive pulmonary disease; Exacerbation; Experimental infection; Rhinovirus