title: Efficacy of albendazole against Taenia multiceps larvae in experimentally infected goats.
abstract: A controlled trial was conducted to evaluate the efficacy of three therapeutics regimes of albendazole (ABZ) against Taenia multiceps larvae in experimental infected goats. Forty-nine goats experimentally infected with 3000 T. multiceps eggs were selected and randomly divided into treatment or control groups. Treatment with 10mg/kg for 3 days for group 1 (G1), 10mg/kg for group 2 (G2) and 20mg/kg/day for group 3 (G3) was applied 2 months after infection; group 4 (G4) served as a control group. A treatment with doses of 10mg/kg/day for 3 days on group 5 (G5) and group 6 (G6) was used as control, 5 months after the infection. The efficacy of ABZ was assessed as percentage of non-viable cysts which were determined by morphologic characteristics, movement and methyl blue staining technique. The efficacy of ABZ against 2 months old cysts was significantly different from the control and were 90.3% (28/31), 72.7% (8/11) and 73.9% (14/19) for G1, G2 and G3, respectively. No differences were observed in cyst viability between treated and control groups for 5-month old cysts. The results in this study indicate that ABZ is effective in goats against 2-month-old cysts of T. multiceps larva located in tissues outside the brain.
authors.affiliation: Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, km 1.5, P.O. Box 257, Maputo, Mozambique.
authors.forename: Sónia M S
authors.initials: SM
authors.lastname: Afonso
authors.affiliation: Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, km 1.5, P.O. Box 257, Maputo, Mozambique.
authors.forename: Luis
authors.initials: L
authors.lastname: Neves
authors.affiliation: Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, km 1.5, P.O. Box 257, Maputo, Mozambique.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pondja
authors.affiliation: Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, km 1.5, P.O. Box 257, Maputo, Mozambique.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Macuamule
authors.affiliation: School of Life Sciences, University of KwaZulu-Natal, Biological Science Building, Westville Campus, Durban 4000, South Africa.
authors.forename: Samson
authors.initials: S
authors.lastname: Mukaratirwa
authors.affiliation: Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Arboix
authors.affiliation: Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Cristòfol
authors.affiliation: Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, km 1.5, P.O. Box 257, Maputo, Mozambique. Electronic address: bpscapece@yahoo.com.
authors.forename: Bettencourt P S
authors.initials: BP
authors.lastname: Capece
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004195:Disease Models, Animal; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology; D006041:Goats; D007814:Larva / Q000187:drug effects; D010063:Ovum / Q000187:drug effects; D013621:Taenia / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D015766:Albendazole
keywords: Albendazole; Efficacy; Experimental infection; Goats; Taenia multiceps