title: Blood-brain barrier dysfunction, seizures and epilepsy.
abstract: The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis.
authors.affiliation: Academic Medical Center, Department (Neuro)Pathology, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: e.a.vanvliet@uva.nl.
authors.forename: E A
authors.initials: EA
authors.lastname: van Vliet
authors.affiliation: Academic Medical Center, Department (Neuro)Pathology, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Aronica
authors.affiliation: Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Gorter
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology / Q000503:physiopathology*; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology*
keywords: Albumin; Blood–brain barrier; Epileptogenesis; Temporal lobe epilepsy; Traumatic brain injury