title: A meta-analysis of serum cancer antigen 125 array for diagnosis of ovarian cancer in Chinese.
abstract: OBJECTIVE
  To further evaluation the diagnosis accuracy of serum cancer antigen 125 (CA125) in the diagnosis of ovarian cancer in Chinese patients.
  
  
  METHODS
  The PubMed, Wanfang and CNKI databases were electric searched and relevant diagnosis trials were reviewed and finally included in this meta-analysis. The diagnosis sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnostic odds ratio (DOR) and receiver operating characteristic curve were pooled by Meta DiSc 1.4 software.
  
  
  RESULTS
  Nineteen studies with a total of 2426 subjects were included in this meta-analysis. The pooled sensitivity, specificity, +LR, -LR and DOR were 0.75 (95% confidence interval = 0.73-0.78), 0.80 (0.77-0.82), 4.52 (3.27-6.26), 0.31 (0.28-0.35) and 15.76 (10.45-23.75) respectively. The area under the summary receiver operating characteristic curve was 0.84.
  
  
  CONCLUSIONS
  Serum CA125 was potential biomarker for diagnosis of ovarian cancer with acceptable diagnosis value.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Liao
authors.affiliation: Department of Oncology, The People's Hospital of Pi County, Chengdu, 611730, China.
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Gao
authors.forename: Guang-Hong
authors.initials: GH
authors.lastname: Wang
mesh_terms: D044466:Asian People; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins