title: Prediction of future rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) results from an interaction between genetic susceptibility and environmental factors. Several of these factors are known, such as family history of RA, high birth weight, smoking, silica exposure, alcohol nonuse, obesity, diabetes mellitus, rheumatoid factor, anti-citrullinated protein antibody, and genetic variants such as the shared epitope and protein tyrosine phosphatase nonreceptor type 22. The impact of these factors can be modeled in the 2 main groups at risk of RA: family members of patients with RA and seropositive persons with or without arthralgia. Current models have the potential to select individuals for preventive strategies.
authors.affiliation: Department of Rheumatology, Jan van Breemen Research Institute/Reade, Doctor Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands. Electronic address: s.turk@reade.nl.
authors.forename: Samina A
authors.initials: SA
authors.lastname: Turk
authors.affiliation: Department of Rheumatology, Jan van Breemen Research Institute/Reade, Doctor Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands.
authors.forename: Marian H
authors.initials: MH
authors.lastname: van Beers-Tas
authors.affiliation: Department of Rheumatology, Jan van Breemen Research Institute/Reade, Doctor Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands.
authors.forename: Dirkjan
authors.initials: D
authors.lastname: van Schaardenburg
mesh_terms: D064829:Alcohol Abstinence / Q000706:statistics & numerical data*; D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001724:Birth Weight; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008403:Mass Screening; D009765:Obesity / Q000453:epidemiology*; D017584:Reproductive History; D018570:Risk Assessment; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*
chemical_list: D001323:Autoantibodies
keywords: Arthralgia; Autoantibodies; Biomarkers; Environmental; Prediction; Rheumatoid arthritis; Risk factors