title: [Stimuli-sensitive polymer systems].
abstract: The polymers can be found in different forms in solution (particles, capsules, pseudo-micelles, hydrogels…) or on surface with important prospects in many field applications. These polymer systems are particularly very good candidates to entrap, transport and deliver an active substance in biomedical applications however with many limitations on control of release of a given target. The stimuli-sensitive polymers, also called smart or environmentally sensitive polymers, present physical or chemical changes under the action of small variations of an external stimulus. This signal acts as a stimulus which causes the change of conformation and/or solvation of the macromolecular chains by modifying their various interactions. The stimuli are classified into two broad categories: physical or external stimuli: temperature, mechanical stress, light, magnetic and electric fields; chemical and biochemical or internal stimuli: pH, ionic strength, chemical molecule (glucose, redox) or biochemical (enzymes, antigens…). The use of stimuli-sensitive pathway is widely used in the literature to enhance or trigger the release of an active compound. In this paper, we present the different stimuli addressing the theoretical aspects, polymers corresponding to these stimuli. Some examples illustrate these systems for the controlled release of active compounds.
authors.affiliation: Normandie université, France; Laboratoire polymères biopolymères surfaces, université de Rouen, 76821 Mont Saint-Aignan, France; CNRS UMR 6270 & FR3038, 76821 Mont Saint-Aignan, France. Electronic address: didier.lecerf@univ-rouen.fr.
authors.forename: D
authors.initials: D
authors.lastname: Le Cerf
mesh_terms: D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D006801:Humans; D060526:Magnetic Fields; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
chemical_list: D011108:Polymers
keywords: Champ magnétique; Light; Lumière; Magnetic field; Polymer; Polymère; Stimuli; Stimulus; Temperature; Température; pH