title: High rate of inducible clindamycin resistance in Staphylococcus aureus isolates--a multicenter study in Tokyo, Japan.
abstract: The resistance of Staphylococcus aureus (S. aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S. aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S. aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (n = 585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S. aureus isolates in our geographic area.
authors.affiliation: Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address: shoji-k@ncchd.go.jp.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shoji
authors.affiliation: Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan; Center for Infectious Diseases and Infection Control, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shinjoh
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
authors.forename: Yuho
authors.initials: Y
authors.lastname: Horikoshi
authors.affiliation: Department of Education for Clinical Research, National Center for Child Health and Development, Japan.
authors.forename: Julian
authors.initials: J
authors.lastname: Tang
authors.affiliation: Division of Microbiology, Department of Clinical Laboratory Medicine, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Center for Infectious Diseases and Infection Control, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Sugita
authors.affiliation: Division of Microbiology, Department of Laboratory, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tame
authors.affiliation: Center for Infectious Diseases and Infection Control, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
authors.affiliation: Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Miyairi
authors.affiliation: Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002981:Clindamycin / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D015994:Incidence; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014041:Tokyo / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin
keywords: Antistaphylococcal; Clindamycin; Inducible resistance; MRSA; MSSA