title: Electrospun polyurethane/Eudragit ® L100-55 composite mats for the pH dependent release of paclitaxel on duodenal stent cover application.
abstract: A nanofiber composite mat of PU and Eudragit(®) L100-55 was created using electrospinning process. The pH dependent release of paclitaxel was successfully done with the use of PU/EL100-55 nanocomposite mats as the controlling platform. The morphology of the nanofiber composites was surveyed using FESEM and ratios of the polymers affects the diameter of the nanofiber. Characterization of the nanofiber composite mat was done using FTIR, DSC-TGA method. The release rate of paclitaxel was determined and analyzed by in vitro drug release method. In order to mimic the condition of a human duodenum, the fibers were submersed on PBS of different pH levels (4.0, 6.0,) respectively, and then analyzed using high performance liquid chromatography (HPLC). Composite mats submersed in PBS with pH 4.0 showed lesser release profile compared to mats submersed in PBS with pH of 6.0. The composite mat has adequate mechanical properties and in vitro cell biocompatibility indicating that the material can be used for drug eluting stent cover application.
authors.affiliation: Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea.
authors.forename: Ludwig Erik
authors.initials: LE
authors.lastname: Aguilar
authors.affiliation: Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea.
authors.forename: Afeesh Rajan
authors.initials: AR
authors.lastname: Unnithan
authors.affiliation: Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea; Power Engineering School, Mongolian University of Science and Technology, Ulaanbaatar, Mongolia.
authors.forename: Altangerel
authors.initials: A
authors.lastname: Amarjargal
authors.affiliation: Department of Microbiology and Genetics, Medical School, Chonbuk National University, Jeonju City, Republic of Korea.
authors.forename: Arjun Prasad
authors.initials: AP
authors.lastname: Tiwari
authors.affiliation: Department of Microbiology and Genetics, Medical School, Chonbuk National University, Jeonju City, Republic of Korea.
authors.forename: Seong Tshool
authors.initials: ST
authors.lastname: Hong
authors.affiliation: Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea; Eco-friendly Machine Parts Design Research Center, Chonbuk National University, Jeonju City, Republic of Korea. Electronic address: biochan@jbnu.ac.kr.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea; Eco-friendly Machine Parts Design Research Center, Chonbuk National University, Jeonju City, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D049109:Cell Proliferation / Q000187:drug effects; D004339:Drug Compounding; D065546:Drug Liberation; D054855:Drug-Eluting Stents; D004386:Duodenum; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry*; D011140:Polyurethanes / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011109:Polymethacrylic Acids; D011140:Polyurethanes; C038300:methylmethacrylate-methacrylic acid copolymer; D017239:Paclitaxel
keywords: Drug eluting stent; Electrospinning; Eudragit; Nanofiber; pH sensitive polymers