title: Liquid biopsies in lung cancer: the new ambrosia of researchers.
abstract: In the last decades the approach to cancer patient management has been deeply revolutionized. We are moving from a "one-fits-all" strategy to the "personalized medicine" based on the molecular characterization of the tumor. In this new era it is becoming more and more clear that the monitoring of the disease is fundamental for the success of the treatment, thus there is the need of new biomarker discovery. More precisely in the last years the scientific community has started to use the term "liquid biopsy". A liquid biopsy is a liquid biomarker that can be easily isolated from many body fluids (blood, saliva, urine, ascites, pleural effusion, etc.) and, as well as a tissue biopsy, a representative of the tissue from which it is spread. In this review we will focus our attention on circulating tumor cells, circulating tumor DNA, exosomes and secretomes with the aim to underlie their usefulness and potential application in a clinical setting for lung cancer patient management.
authors.affiliation: Phase I - Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium. Electronic address: christian.rolfo@uza.be.
authors.forename: Christian
authors.initials: C
authors.lastname: Rolfo
authors.affiliation: Molecular Pathology Unit, Pathology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium; Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Via Liborio Giuffrè 5, Palermo 90127, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Castiglia
authors.affiliation: Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Holcombe Blvd 1400, Unit 455, Houston 77030, USA.
authors.forename: David
authors.initials: D
authors.lastname: Hong
authors.affiliation: Department of Biopathology and Medical and Forensic Biotechnologies, Section of Biology and Genetics, University of Palermo, Via Divisi 81-85, 90133 Palermo, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Alessandro
authors.affiliation: Center for Proteomics, VITO, Boeretang 200, Mol, BE-2400, Belgium, Antwerp University, Groenenborgerlaan 171, Antwerpen 2020, Belgium.
authors.forename: Inge
authors.initials: I
authors.lastname: Mertens
authors.affiliation: Center for Proteomics, VITO, Boeretang 200, Mol, BE-2400, Belgium, Antwerp University, Groenenborgerlaan 171, Antwerpen 2020, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Baggerman
authors.affiliation: Molecular Pathology Unit, Pathology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium.
authors.forename: Karen
authors.initials: K
authors.lastname: Zwaenepoel
authors.affiliation: Lung Cancer Unit, Department of Oncology, Clínica Universidad de Navarra, Avenida Pío XII 36, Pamplona 31008, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Gil-Bazo
authors.affiliation: Phase I - Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium; Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Via Liborio Giuffrè 5, Palermo 90127, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Passiglia
authors.affiliation: Phase I - Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium; Molecular Pathology Unit, Pathology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium.
authors.forename: Anna P
authors.initials: AP
authors.lastname: Carreca
authors.affiliation: Department of Biopathology and Medical and Forensic Biotechnologies, Section of Biology and Genetics, University of Palermo, Via Divisi 81-85, 90133 Palermo, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Taverna
authors.affiliation: Laboratory of Biochemistry, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Polyclinic, University of Palermo, Viale delle Scienze, Ed. 13, 90128 Palermo, Italy.
authors.forename: Renza
authors.initials: R
authors.lastname: Vento
authors.affiliation: Medical Oncology Department, University Campus Bio-Medico, Rome, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.affiliation: Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Peeters
authors.affiliation: Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Via Liborio Giuffrè 5, Palermo 90127, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.affiliation: Molecular Pathology Unit, Pathology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Pauwels
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004273:DNA, Neoplasm / Q000097:blood; D055354:Exosomes; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D009360:Neoplastic Cells, Circulating
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Biomarkers; Circulating tumor DNA; Circulating tumor cells; Exosomes; Lung cancer