title: Corneal lymphangiogenesis in herpetic stromal keratitis.
abstract: Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immune- and inflammation-mediated damage to the deep layers of the cornea. Current research demonstrates the potential of anti-lymphangiogenic therapy to decrease and prevent herpes-induced lymphangiogenesis.
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Park
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Chang
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Garg
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Chang
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA; Department Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: dshukla@uic.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Shukla
mesh_terms: D000818:Animals; D003315:Cornea / Q000503:physiopathology*; D003319:Corneal Stroma / Q000821:virology; D004195:Disease Models, Animal; D006801:Humans; D016849:Keratitis, Herpetic / Q000188:drug therapy / Q000503:physiopathology*; D042583:Lymphangiogenesis / Q000502:physiology*; D042601:Lymphatic Vessels / Q000503:physiopathology*
keywords: cornea; herpes simplex virus-1; lymphangiogenesis; neovascularization; vascular endothelial growth factor (VEGF)