title: Legionella pneumophila: homeward bound away from the phagosome.
abstract: The intracellular pathogen Legionella pneumophila (Lp) survives and replicates inside a specialized vacuolar compartment that evades canonical phagosomal maturation. Through the action of a large number of effectors translocated into the host cytosol via the Dot/Icm type IV secretion system, Lp subverts host cell pathways to convert its nascent phagosome into an ER-derived compartment, the Legionella containing vacuole (LCV), which serves as bacterial replication niche.
authors.affiliation: Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: Akriti
authors.initials: A
authors.lastname: Prashar
authors.affiliation: Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5. Electronic address: terebiznik@utsc.utoronto.ca.
authors.forename: Mauricio R
authors.initials: MR
authors.lastname: Terebiznik
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D011992:Endosomes / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D016952:Legionella pneumophila / Q000276:immunology / Q000502:physiology*; D010588:Phagosomes / Q000382:microbiology*; D021381:Protein Transport; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D037521:Virulence Factors