title: Early treatment with infliximab in bilateral occlusive vasculitis as a presenting manifestation of Behçet' disease.
abstract: METHODS
  A 24 year old woman who complained of maculo-papulo rash, genital and bucal aphthous ulcers, abdominal pain, minor dyspnea and visual loss in both eyes. Funduscopy revealed a bilateral occlusive vasculitis including central vessels. Treatment was initiated with a methylprednisolone bolus (1 g/24h) and infliximab 5mg/kg/day (0-2-6 weeks and every 8 weeks). The treatment prescribed induced a fast remission. Visual acuity improved. The patient did not suffer any other relapse after one year of follow-up.
  
  
  CONCLUSIONS
  An initial treatment with Infliximab should be considered in Behçet disease for serious outbreaks, such as macular occlusive vasculitis with ischemia.
authors.affiliation: Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSSC), Madrid, España. Electronic address: paulabaneros@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Bañeros-Rojas
authors.affiliation: Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSSC), Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Berrozpe-Villabona
authors.affiliation: Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSSC), Madrid, España.
authors.forename: J E
authors.initials: JE
authors.lastname: Peraza-Nieves
authors.affiliation: Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSSC), Madrid, España; RETICS RD07/0062 (Oftalmología), Instituto de Salud Carlos III, Red temática de Investigación Cooperativa, Proyecto RD 07/0062: Patología ocular del envejecieminto, calidad visual y calidad de vida. Madrid, España; Grupo de Investigación, Universidad Complutense de Madrid 920415-GR58/08, Madrid, España.
authors.forename: D
authors.initials: D
authors.lastname: Díaz-Valle
mesh_terms: D001528:Behcet Syndrome / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D000069285:Infliximab / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use*; D009887:Ophthalmoscopy; D012074:Remission Induction; D041623:Tomography, Optical Coherence; D014657:Vasculitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D000069285:Infliximab; D008775:Methylprednisolone
keywords: Behçet disease; Enfermedad de Behçet; Infliximab; Retinal vasculitis; TNF-α; Uveitis; Uveítis; Vasculitis retiniana