title: [Comparison of the Disease Activity Score-28 and Juvenile Arthritis Disease Activity Score in the juvenile idiopathic arthritis].
abstract: BACKGROUND
  the assessment of the activity of rheumatoid arthritis and juvenile idiopathic arthritis is made by means of different tools, respectively DAS-28 and JADAS.
  
  
  OBJECTIVE
  To compare DAS-28 and JADAS with scores of 71, 27 and 10 joint counts in juvenile idiopathic arthritis.
  
  
  METHODS
  A secondary analysis of a phase III placebo-controlled trial, testing safety and efficacy of abatacept was conducted in 8 patients with 178 assessment visits. Joint count scores for active and limited joints, physician's and parents' global assessment by 0-10cm Visual Analog Scale, and erythrocyte sedimentation rate normalized to 0-10 scale, in all visits. The comparison among the activity indices in different observations was made through Anova or adjusted gamma model. The paired observations between DAS-28 and JADAS 71, 27 and 10, respectively, were analyzed by linear regression.
  
  
  RESULTS
  There were significant differences among individual measures, except for ESR, in the first four months of biological treatment, when five of the eight patients reached ACR-Pedi 30, with improvement. The indices of DAS-28, JADAS 71, 27 and 10 also showed significant difference during follow-up. Linear regression adjusted model between DAS-28 and JADAS resulted in mathematical formulas for conversion: [DAS-28=0.0709 (JADAS 71)+1.267] (R(2)=0.49); [DAS-28=0.084 (JADAS 27) +1.7404] (R(2)=0.47) and [DAS-28=0.1129 (JADAS-10) +1.5748] (R(2)=0.50).
  
  
  CONCLUSIONS
  The conversion of scores of DAS-28 and JADAS 71, 27 and 10 for this mathematical model would allow equivalent application of both in adolescents with arthritis.
authors.affiliation: Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.
authors.forename: Renata Campos
authors.initials: RC
authors.lastname: Capela
authors.affiliation: Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Corrente
authors.affiliation: Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil. Electronic address: claudi@fmb.unesp.br.
authors.forename: Claudia Saad
authors.initials: CS
authors.lastname: Magalhães
mesh_terms: D000069594:Abatacept / Q000627:therapeutic use*; D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000175:diagnosis* / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index
chemical_list: D018501:Antirheumatic Agents; D000069594:Abatacept
keywords: Artrite idiopática juvenil; Artrite reumatoide; Disease Activity Score‐28; Juvenile Arthritis Disease Activity Score; Juvenile idiopathic arthritis; Rheumatoid arthritis