title: Multidrug-resistant Acinetobactor baumannii isolated from a traveler returned from Brunei.
abstract: We report a case of multidrug-resistant (MDR) Acinetobactor baumannii isolates obtained from a traveler returned from Brunei. Whole-genome sequencing analysis revealed that the isolates harbored blaOxA-23 and armA. The minimum inhibitory concentrations of antibiotics against the strain were as follows: imipenem, 32 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, ≧ 1024 μg/ml; arbekacin, ≧ 1024 μg/ml; aztreonam, 64 μg/ml; colistin, 4 μg/ml. A. baumannii harboring both blaOxA-23 and armA is rarely reported in Japan, and, to the best of our knowledge, this is the second report of A. baumannii harboring both resistant genes in Japan.
authors.affiliation: Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Disease Control and Prevention Center, Japan; Department of Infectious Diseases, Research Institute, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Tojo
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Mawatari
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Hayakawa
authors.affiliation: Disease Control and Prevention Center, Japan; Department of Infectious Diseases, Research Institute, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Nagamatsu
authors.affiliation: Department of Infectious Diseases, Research Institute, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Clinical Laboratory, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mezaki
authors.affiliation: Infection Control and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sugiki
authors.affiliation: Infection Control and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Kuroda
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kutsuna
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujiya
authors.affiliation: Department of Infectious Diseases, Research Institute, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Miyoshi-Akiyama
authors.affiliation: Department of Infectious Diseases, Research Institute, Japan. Electronic address: tkirikae@ri.ncgm.go.jp.
authors.forename: Teruo
authors.initials: T
authors.lastname: Kirikae
authors.affiliation: Disease Control and Prevention Center, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ohmagari
mesh_terms: D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000201:enzymology / Q000302:isolation & purification*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D001426:Bacterial Proteins / Q000378:metabolism; D002010:Brunei / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D014195:Travel; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008780:Methyltransferases; D001618:beta-Lactamases; C000599728:beta-lactamase OXA-23, Acinetobacter baumannii
keywords: 16S rRNA methylase; Acinetobacter baumannii; Antimicrobial resistance; Carbapenemase; armA; bla(OxA-23)