title: Should we be more cautious about replacement of vitamin B12 in patients with cancer receiving cytotoxic chemotherapy?
abstract: Vitamin B12 (Cbl) deficiency may cause hematologic and neurologic dysfunction. Replacement therapy is effective in correcting hematologic abnormalities and improving neurologic symptoms. Cbl is known to have antioxidant activity. This antioxidant activity may antagonize the effects of chemotherapeutics (i.e. genotoxic effects of paclitaxel) on tumor DNA. We claim that Cbl replacement should be done more cautiously in patients receiving cytotoxic chemotherapy.
authors.affiliation: Department of Medical Oncology, Yeditepe University Hospital, Istanbul, Turkey. Electronic address: droneren@hotmail.com.
authors.forename: Orhan Onder
authors.initials: OO
authors.lastname: Eren
authors.affiliation: Department of Internal Medicine, Yeditepe University Hospital, Istanbul, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ozturk
authors.affiliation: Department of Medical Oncology, Yeditepe University Hospital, Istanbul, Turkey.
authors.forename: Ozlem Uysal
authors.initials: OU
authors.lastname: Sonmez
authors.affiliation: Department of Medical Oncology, Yeditepe University Hospital, Istanbul, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Oyan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry; D004273:DNA, Neoplasm / Q000378:metabolism; D004347:Drug Interactions; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D014805:Vitamin B 12 / Q000009:adverse effects / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D004273:DNA, Neoplasm; D005609:Free Radicals; D014805:Vitamin B 12