title: Medical genetics-based drug repurposing for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a disease that threatens the elderly. No efficient therapeutic method is currently available to combat AD. Drug repurposing has provided a new route for AD drug discovery, and medical genetics has shown potential in target-based drug repurposing. We compared AD-associated genes with approved drug targets and found that three are targeted by 23 approved drugs. Thus, these drugs may be used to treat AD according to the medical genetic information of the targets. In vitro and in vivo experiments revealed that four drugs, all of which are angiotensin-converting enzyme (ACE) inhibitors, had potential to treat AD.
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China. Electronic address: sleevexz@sdut.edu.cn.
authors.forename: Xiu-Zhen
authors.initials: XZ
authors.lastname: Zhang
authors.affiliation: Agricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: 1309458172@qq.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Quan
authors.affiliation: Agricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: gytang@mail.hzau.edu.cn.
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Tang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D058492:Drug Repositioning / Q000379:methods*; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D018697:Nootropic Agents
keywords: Alzheimer's disease; Angiotensin-converting enzyme inhibitors; Drug repurposing; Medical genetics