title: Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment.
abstract: BACKGROUND
  Current research is concerned with discovering better scaffolds for use in regenerative endodontic treatment. This study aimed to clinically and radiographically evaluate the efficacy of platelet-rich plasma (PRP) used as a scaffold in regenerative endodontic treatment and compare it with that of a conventional blood clot (BC) scaffold.
  
  
  METHODS
  A total of 20 necrotic, single-rooted immature teeth were randomly distributed into 2 groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created by using either PRP or BC and covered with white mineral trioxide aggregate. Clinical and radiographic follow-up examinations were performed once every 3 months during an 18-month period. Differences in root area were calculated from preoperative and postoperative radiographs. Fisher exact and Mann-Whitney U tests were used to evaluate differences between groups, with P value <.05 considered to be statistically significant.
  
  
  RESULTS
  All 20 teeth were clinically asymptomatic during 18-month follow-up period; however, 1 tooth in the BC group exhibited periapical pathosis and was judged radiographically unsuccessful. Complete apical closure was observed in a mean of 8.1 months in the PRP group compared with 9 months in the BC group. The PRP group exhibited 9.86% increase in root area, compared with 12.6% increase in the BC group. The difference in success rates between the groups was not statistically significant (P > .05).
  
  
  CONCLUSIONS
  PRP successfully created a scaffold for regenerative endodontic treatment; however, treatment outcomes did not differ significantly between PRP and conventional BC scaffold.
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Ankara University, Ankara, Turkey. Electronic address: cetintugba@yahoo.com.
authors.forename: Tugba
authors.initials: T
authors.lastname: Bezgin
authors.affiliation: Molecular Biology Laboratory, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Ayca Dilara
authors.initials: AD
authors.lastname: Yilmaz
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Burcu Nihan
authors.initials: BN
authors.lastname: Celik
authors.affiliation: Department of Maxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Mehmet Eray
authors.initials: ME
authors.lastname: Kolsuz
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Sonmez
mesh_terms: D000293:Adolescent; D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017610:Calcium Compounds; D002648:Child; D003782:Dental Pulp; D003790:Dental Pulp Necrosis / Q000473:pathology / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D010087:Oxides; D053657:Platelet-Rich Plasma; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation; D012390:Root Canal Therapy / Q000379:methods*; D017640:Silicates; D013927:Thrombosis; D054457:Tissue Scaffolds; D019227:Tooth Apex / Q000187:drug effects / Q000473:pathology; D014092:Tooth Root / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate
keywords: Blood clot; immature teeth; platelet-rich plasma; regenerative endodontic treatment