title: Urinary bisphenol A and semen quality, the LIFE Study.
abstract: Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer products, has been negatively associated with sperm quality. This study aimed to estimate the association between BPA and 35 measures of semen quality among reproductive aged men recruited from 16 counties in Michigan and Texas, 2005-2009. Of 501 enrolled males, 418 (83.4%) provided a urine sample and at least one semen sample. Linear and logistic regression models assessed the association between urinary BPA levels and individual semen quality endpoints. Generalized estimating equations were used to account for repeated measures of semen quality and adjusted models accounted for 11 a priori covariates. Geometric mean total urinary BPA concentration among participants was 0.55ng/mL (95% CI 0.49-0.63). A negative relation between BPA and DNA fragmentation was the sole significant finding in adjusted linear regression (β=-0.0544, p=0.035) and suggestive of less sperm DNA damage.
authors.affiliation: Department of Environmental & Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Goldstone
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Environmental & Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Perry
authors.affiliation: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Environmental Health Sciences, School of Public Health, The University at Albany-SUNY, Albany, NY, USA.
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA. Electronic address: louisg@mail.nih.gov.
authors.forename: Germaine M Buck
authors.initials: GM
authors.lastname: Louis
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D053938:DNA Fragmentation; D004785:Environmental Pollutants / Q000652:urine*; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D010636:Phenols / Q000652:urine*; D011446:Prospective Studies; D055101:Semen Analysis; D013781:Texas / Q000453:epidemiology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; DNA fragmentation; Endocrine disruptors; Fecundity; Fertility; Semen; Sperm; Sperm chromatin structure assay.