title: Large solitary fibrous tumor of the oral cavity--report of a case.
abstract: The solitary fibrous tumor (SFT) is a rare soft tissue tumor with a substantially benign clinical behavior. The SFT of the oral cavity is a very uncommon entity. It is also of complicated diagnosis because of its extensive morphologic diversity and because of its similarity to many mesenchymal tumors. A 44-year-old man was referred for management of an asymptomatic lesion in the left buccal mucosa, which had been identified 10 years earlier. Intra-oral examination revealed a well-demarcated, fibroelastic, rounded exophytic mass located in the left buccal mucosa. The mass was covered with a non-ulcerated mucosa of normal color and measured approximately 4.0 cm in diameter. Histopathological examination showed proliferation of spindle-shaped cells arranged in fascicles and in a patternless pattern, highly vascularized, with focal staghorn vessels. Immunohistochemical analysis revealed diffuse positivity for CD34 and focal positivity for Bcl-2. Awareness of the morphological diversity of SFT coupled to a judicious use of appropriate immunohistochemical probes should prove valuable to accurately segregate SFT from other spindle cell neoplasms.
authors.affiliation: Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil. Electronic address: denisehelen2011@hotmail.com.
authors.forename: Denise Hélen Imaculada Pereira
authors.initials: DH
authors.lastname: de Oliveira
authors.affiliation: Division of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: Assis Filipe Medeiros
authors.initials: AF
authors.lastname: Albuquerque
authors.affiliation: Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: Matheus Dantas
authors.initials: MD
authors.lastname: de Araújo Barreto
authors.affiliation: State University of Paraíba, Campina Grande, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: Cassiano Francisco Weege
authors.initials: CF
authors.lastname: Nonaka
authors.affiliation: Division of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: José Sandro Pereira
authors.initials: JS
authors.lastname: da Silva
authors.affiliation: Division of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: Adriano Rocha
authors.initials: AR
authors.lastname: Germano
authors.affiliation: Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000 Natal, RN, Brazil.
authors.forename: Lélia Maria Guedes
authors.initials: LM
authors.lastname: Queiroz
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009055:Mouth / Q000473:pathology*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D054364:Solitary Fibrous Tumors / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; C000595707:BCL2 protein, human; D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2
keywords: CD34; Differential diagnosis; Immunohistochemistry; Oral cavity; Solitary fibrous tumor