title: Three key regions for supervisory attentional control: evidence from neuroimaging meta-analyses.
abstract: The supervisory attentional system has been proposed to mediate non-routine, goal-oriented behaviour by guiding the selection and maintenance of the goal-relevant task schema. Here, we aimed to delineate the brain regions that mediate these high-level control processes via neuroimaging meta-analysis. In particular, we investigated the core neural correlates of a wide range of tasks requiring supervisory control for the suppression of a routine action in favour of another, non-routine one. Our sample comprised n=173 experiments employing go/no-go, stop-signal, Stroop or spatial interference tasks. Consistent convergence across all four paradigm classes was restricted to right anterior insula and inferior frontal junction, with anterior midcingulate cortex and pre-supplementary motor area being consistently involved in all but the go/no-go task. Taken together with lesion studies in patients, our findings suggest that the controlled activation and maintenance of adequate task schemata relies, across paradigms, on a right-dominant midcingulo-insular-inferior frontal core network. This also implies that the role of other prefrontal and parietal regions may be less domain-general than previously thought.
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich, Leo-Brandt-Straße, 52428 Jülich, Germany. Electronic address: e.cieslik@fz-juelich.de.
authors.forename: Edna C
authors.initials: EC
authors.lastname: Cieslik
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich, Leo-Brandt-Straße, 52428 Jülich, Germany.
authors.forename: Veronika I
authors.initials: VI
authors.lastname: Mueller
authors.affiliation: Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich, Leo-Brandt-Straße, 52428 Jülich, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen, University, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Claudia R
authors.initials: CR
authors.lastname: Eickhoff
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich, Leo-Brandt-Straße, 52428 Jülich, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Langner
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich, Leo-Brandt-Straße, 52428 Jülich, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
mesh_terms: D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans
keywords: Go/no-go; Meta-analysis; PET; Spatial interference; Stop signal; Stroop; Supervisory attentional system; fMRI