title: Site selective activation of lateral hypothalamic mGluR1 and R5 receptors elicits feeding in rats.
abstract: Recent findings from our lab indicate that metabotropic glutamate receptor (mGluR) activation elicits eating, and the goal of the current study was to specify whether the lateral hypothalamus (LH) is the actual brain site mediating this effect. To examine this issue we injected the selective mGluR group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) unilaterally into the LH and surrounding regions (n=5-8 subjects/brain site) of satiated adult male Sprague-Dawley rats and measured elicited feeding. We determined that 1.0 nmol elicited food intake only within the LH. Increasing the dose to 10 or 25 nmol produced a more sustained effect in the LH, and also elicited eating in several other brain sites. These results, demonstrating that the LH mediates the eating elicited by low doses of DHPG, suggest that the LH may contain mGluR whose activation can produce eating behavior.
authors.affiliation: Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA. Electronic address: jchar008@ucr.edu.
authors.forename: J R
authors.initials: JR
authors.lastname: Charles
authors.affiliation: Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA.
authors.forename: E
authors.initials: E
authors.lastname: Hernandez
authors.affiliation: Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA.
authors.forename: A
authors.initials: A
authors.lastname: Winter
authors.affiliation: Eli Lilly & Co., Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Yang
authors.affiliation: Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA; Department of Psychology, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA.
authors.forename: B G
authors.initials: BG
authors.lastname: Stanley
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D008297:Male; D020645:Mediodorsal Thalamic Nucleus / Q000187:drug effects / Q000502:physiology; D017207:Rats, Sprague-Dawley; D064529:Receptor, Metabotropic Glutamate 5 / Q000819:agonists / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000378:metabolism*; D012118:Resorcinols / Q000494:pharmacology; D012527:Satiation / Q000187:drug effects / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D013788:Thalamus / Q000187:drug effects / Q000502:physiology
chemical_list: D018690:Excitatory Amino Acid Agonists; C578937:Grm5 protein, rat; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C104077:metabotropic glutamate receptor type 1; C079215:3,5-dihydroxyphenylglycine; D005998:Glycine
keywords: Feeding; Glutamate; Glutamate receptor; Lateral hypothalamus; Metabotropic