title: Coupling of replication and assembly in flaviviruses.
abstract: Flaviviruses affect hundreds of millions of people each year causing tremendous morbidity and mortality worldwide. This genus includes significant human pathogens such as dengue, West Nile, yellow fever, tick-borne encephalitis and Japanese encephalitis virus among many others. The disease caused by these viruses can range from febrile illness to hemorrhagic fever and encephalitis. A deeper understanding of the virus life cycle is required to foster development of antivirals and vaccines, which are an urgent need for many flaviviruses, especially dengue. The focus of this review is to summarize our current knowledge of flaviviral replication and assembly, the proteins and lipids involved therein, and how these processes are coordinated for efficient virus production.
authors.affiliation: Markey Center for Structural Biology, Department of Biological Sciences and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
authors.forename: Swapna
authors.initials: S
authors.lastname: Apte-Sengupta
authors.affiliation: Markey Center for Structural Biology, Department of Biological Sciences and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
authors.forename: Devika
authors.initials: D
authors.lastname: Sirohi
authors.affiliation: Markey Center for Structural Biology, Department of Biological Sciences and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA. Electronic address: kuhnr@purdue.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kuhn
mesh_terms: D005416:Flavivirus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D050356:Lipid Metabolism; D014764:Viral Proteins / Q000378:metabolism; D019065:Virus Assembly; D014779:Virus Replication
chemical_list: D014764:Viral Proteins