title: First reported human case of native mitral infective endocarditis caused by Streptococcus canis.
abstract: A 65 year-old woman was admitted for acute heart failure and severe sepsis revealing definite mitral infective endocarditis with severe regurgitation, complicated by multiple embolisms. Three blood cultures yielded a group G Streptococcus canis strain. Urgent surgery was performed with bioprosthetic valve replacement. Polymerase chain reaction analysis of the valve found S canis DNA. Amoxicillin and gentamicin were given for 2 weeks followed by 4 weeks of amoxicillin alone. She reported contact with a dog without bite. S canis has been reported to cause zoonotic septicemia but to our knowledge, this is the first human case of native valve infective endocarditis.
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France. Electronic address: myriam.amsallem@gmail.com.
authors.forename: Myriam
authors.initials: M
authors.lastname: Amsallem
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bouleti
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Armand-Lefevre
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Anne-Line
authors.initials: AL
authors.lastname: Eme
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Aziza
authors.initials: A
authors.lastname: Touati
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kirsch
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Duval
authors.affiliation: Department of Cardiology, Bichat Claude Bernard Hospital, AP-HP, Paris Diderot University, Paris, France.
authors.forename: Alec
authors.initials: A
authors.lastname: Vahanian
mesh_terms: D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000032:analysis; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D013290:Streptococcal Infections / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D013291:Streptococcus / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial