title: Fatty acids and the risk of death during acute myocardial ischaemia.
abstract: Plasma free fatty acids (non-esterified fatty acids) increase in the first hour of the onset of acute myocardial ischaemia. This results from catecholamine stimulation of adipose tissue lipolysis. It can lead to a metabolic crisis in the injured myocardium with the development of ventricular arrhythmias and increased early mortality. Preconditioning, β-adrenergic blockade and glucose-insulin-potassium are possible therapeutic approaches, but anti-lipolytic agents, such as some nicotinic acid derivatives, can reduce plasma free fatty acid concentrations within minutes and have untried potential. A clinical trial of their effectiveness is needed from the first moment when a patient with an acute coronary syndrome is seen by paramedics.
authors.affiliation: *University of Edinburgh, Scotland, U.K.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Oliver
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood* / Q000502:physiology; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008066:Lipolysis / Q000187:drug effects; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000401:mortality; D009206:Myocardium / Q000378:metabolism; D009525:Niacin / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D009525:Niacin