title: [Fatal Panton-Valentine leukocidine-associated Staphylococcus aureus necrotizing pneumonia].
abstract: Panton-Valentine leukocidin-producing Staphylococcus aureus necrotizing pneumonia is an unusual cause of community-acquired pneumonia associated with a high fatality rate. The specificities of its presentation must be known by the critical care doctor, in order to quickly make the diagnosis and start the right antibiotics and discuss adjunctive therapy with intravenous immunoglobin. Moreover, the management of close contacts (household and healthcare workers) of patient with such a pneumonia is not well-known. The present case report underlines the clinical presentation of this pneumonia, the specificities of its treatment, and specifies the management of close contacts.
authors.affiliation: Service de réanimation médico-chirurgicale, centre hospitalier de Versailles, site André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: F
authors.initials: F
authors.lastname: Laverdure
authors.affiliation: Service de prévention du risque infectieux, centre hospitalier de Versailles, site André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: C
authors.initials: C
authors.lastname: Neulier
authors.affiliation: Service de pédiatrie, centre hospitalier de Poissy, 78300 Poissy, France.
authors.forename: J
authors.initials: J
authors.lastname: Sudant
authors.affiliation: Service de réanimation médico-chirurgicale, centre hospitalier de Versailles, site André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: S
authors.initials: S
authors.lastname: Legriel
authors.affiliation: Service de réanimation médico-chirurgicale, centre hospitalier de Versailles, site André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: fbruneel@ch-versailles.fr.
authors.forename: F
authors.initials: F
authors.lastname: Bruneel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000032:analysis / Q000378:metabolism*; D019090:Case Management; D016358:Contact Tracing; D005098:Exotoxins / Q000032:analysis / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007956:Leukocidins / Q000032:analysis / Q000378:metabolism*; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D016756:Immunoglobulins, Intravenous; D007956:Leukocidins; C078284:Panton-Valentine leukocidin
keywords: Cas contact; Contacts; Dépistage; Leucocidine de Panton-Valentine; Panton-Valentine leukocidin; Pneumonia; Pneumonie; Screening; Staphylococcus