title: The T29C (rs1800470) polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with restenosis after coronary stenting in Mexican patients.
abstract: The aim of the present study was to establish the role of IL-6 and TGF-β1 gene polymorphisms in the risk of developing in-stent restenosis. Two IL-6 [rs1800796 (-572 G>C), rs2069827 (-1426 T>G)] and two TGF-β1 [rs1800469 (-509 T>C), rs1800470 (T29C)] gene polymorphisms were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 244 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis. Under the dominant and additive models adjusted for hypertension, stable angina, stent used, and diameter of stent, the TGF-β1 T29C (rs1800470) polymorphism was significantly associated with an increase risk of restenosis when compared to patients without restenosis (OR=2.06, 95% CI: 1.03-4.11, P(Dom)=0.034 and OR=1.64, 95% CI: 1.09-2.45, PAdd=0.016). TGF-β1 polymorphisms were in linkage disequilibrium and one haplotype (TT) was significantly increased in patients with restenosis when compared to patients without restenosis (OR=2.03, P=0.041). In summary, our results suggest that the TGF-β1 T29C gene polymorphism could be involved in the risk of developing restenosis after coronary stent placement.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.affiliation: Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Zuñiga-Ramos
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Marva
authors.initials: M
authors.lastname: Arellano-González
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Edith
authors.initials: E
authors.lastname: Alvarez-León
authors.affiliation: Laboratory of Genomics, Instituto Nacional de Medicina Genomica, Mexico City, Mexico.
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Villegas-Torres
authors.affiliation: Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cruz-Lagunas
authors.affiliation: Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Hilda
authors.initials: H
authors.lastname: Delgadillo-Rodriguez
authors.affiliation: Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Peña-Duque
authors.affiliation: Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: gvargas63@yahoo.com.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000601:surgery*; D023903:Coronary Restenosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011183:Postoperative Complications; D011379:Prognosis; D015607:Stents; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1
keywords: Coronary artery disease; Genetic susceptibility; Polymorphisms; Restenosis; Transforming growth factor-β1