title: In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent.
abstract: In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional--PDT and imaging--gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species--singlet oxygen--before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy.
authors.affiliation: Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; Ministry of Education Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, People's Republic of China; and.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR;
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Lan
authors.affiliation: Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR;
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Chan
authors.affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
authors.forename: Ga-Lai
authors.initials: GL
authors.lastname: Law
authors.affiliation: Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
authors.affiliation: Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
authors.forename: Ka-Leung
authors.initials: KL
authors.lastname: Wong
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005682:Gadolinium / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy
chemical_list: D005682:Gadolinium
keywords: gadolinium; imaging; in vivo PDT; survivin; tumor recognition