title: Can dopamine agonists trigger tactile hallucinations in patients with Parkinson's disease?
abstract: Various hallucinations are unpleasant for patients with Parkinson's disease (PD). Hallucinations are often related to anti-parkinsonian drugs. Tactile hallucinations rarely occur in patients with PD. In contrast to other types of hallucinations, tactile hallucinations often make physicians wonder if a physical abnormality is the underlying cause. However, the relation of tactile hallucinations to anti-parkinsonian drugs remains uncertain because studies are scant. We describe three patients with PD who had tactile hallucinations that were triggered by dopamine agonists. In our patients, tactile hallucinations occurred in a clear sensorium and persisted for a prolonged time. Two patients had clear visual hallucinations such as of insects, which were associated with tactile hallucinations such as of insects tied to the body. Clear tactile sensoria were unpleasant. Dopamine agonists were initiated or the doses were increased during several periods immediately before the onset of tactile hallucinations. Although the other anti-parkinsonian drugs used, such as amantadine, zonisamide, or trihexyphenidyl, were likely to be partly responsible for the tactile hallucinations, our observations suggest that an increase in the dose of dopamine agonists can trigger tactile hallucinations.
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara, Japan. Electronic address: hk55@naramed-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sawa
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sugie
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists
keywords: Cenesthetic hallucinations; Dopamine agonist; Dopaminergic treatment; Hallucinations; Parkinson; Tactile hallucinations