title: Diabetes and cognition.
abstract: Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107, USA. Electronic address: elizabeth.mayeda@ucsf.edu.
authors.forename: Elizabeth Rose
authors.initials: ER
authors.lastname: Mayeda
authors.affiliation: Epidemiology, Etiology & Prevention, Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USA.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Whitmer
authors.affiliation: Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, Box VAMC - 181, San Francisco, CA 94143, USA; San Francisco Veterans Affairs Medical Center, 4150 Clements St Box VAMC - 181, San Francisco, CA 94121, USA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
mesh_terms: D000367:Age Factors; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology / Q000523:psychology*; D006801:Humans; D012307:Risk Factors
keywords: Aging; Cognition; Cognitive decline; Dementia; Epidemiology; Type 2 diabetes