title: Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension.
abstract: We assessed whether red cell distribution width (RDW) is associated with serum uric acid (UA) level in a group of 512 patients with newly diagnosed hypertension, recruited in Beijing. Patients were divided into high uric acid group and low uric acid group according to the median (334.9 μmol/L) of serum uric acid. Compared with the low uric acid group, the patients with high uric acid had higher red blood cell count (P < 0.001) and RDW (P = 0.032). The multiple linear regression analysis showed that RDW (P = 0.001) was positively correlated with uric acid level after the adjustment of related factors. Stepwise multiple logistic regression model confirmed that RDW (odds ratio: OR = 1.75) was independent determinants of high serum uric acid as well as sex (OR = 6.03), triglycerides (OR = 1.84), and Blood Urea Nitrogen (BUN, OR = 1.30). RDW may be independently associated with serum UA level in patients with newly diagnosed hypertension. To firmly establish the causal role of RDW in the incidence of high uric acid level among hypertensive patients, large cohort studies are needed.
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Key Laboratory of Traditional Chinese Medicine Gan Organ of SATCM, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410078 China.
authors.forename: Min
authors.initials: M
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410078 China.
authors.forename: Zhan-Zhan
authors.initials: ZZ
authors.lastname: Li
authors.affiliation: Department of emergency, Chinese Medicine Hospital of Henan Province, Zhengzhou, Henan Province, 450002 China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410078 China.
authors.forename: Li-Zhang
authors.initials: LZ
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410078 China.
authors.forename: Shi-Peng
authors.initials: SP
authors.lastname: Yan
authors.affiliation: Xiangya Medical School, Central South University, Changsha, Hunan Province, 410078 China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Hunan provincial tumor hospital, Changsha, Hunan Province, 410013 China.
authors.forename: Ying-Yun
authors.initials: YY
authors.lastname: Hu
mesh_terms: D003430:Cross-Sectional Studies; D004906:Erythrocyte Count / Q000379:methods; D004912:Erythrocytes / Q000502:physiology*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D014280:Triglycerides; D014527:Uric Acid