title: Chemical cryptology of cancer's histone code.
abstract: Somatic mutations in non-Hodgkin's lymphoma frequently activate EZH2, a protein methyltransferase responsible for H3K27 trimethylation. In this issue of Chemistry and Biology, Bradley and coworkers describe a new set of EZH2 inhibitors amenable to probing the targetable role of H3K27 trimethylation in lymphoma.
authors.affiliation: Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
authors.forename: Rhushikesh A
authors.initials: RA
authors.lastname: Kulkarni
authors.affiliation: Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: jordan.meier@nih.gov.
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Meier
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000633:toxicity*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D063151:Polycomb Repressive Complex 2 / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries / Q000633:toxicity*
chemical_list: D004791:Enzyme Inhibitors; D006657:Histones; D054852:Small Molecule Libraries; D063151:Polycomb Repressive Complex 2