title: ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway.
abstract: Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.
authors.forename: Ha-Reum
authors.initials: HR
authors.lastname: Lee
authors.forename: Scarlett Yoona
authors.initials: SY
authors.lastname: Huh
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Hur
authors.forename: Hyuk
authors.initials: H
authors.lastname: Jeong
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Kim
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Seung Beom
authors.initials: SB
authors.lastname: Park
authors.forename: Yoolhee
authors.initials: Y
authors.lastname: Yang
authors.forename: Sa Ik
authors.initials: SI
authors.lastname: Bang
authors.forename: Hyunjeong
authors.initials: H
authors.lastname: Park
authors.forename: Daeho
authors.initials: D
authors.lastname: Cho
mesh_terms: D000199:Actins / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000276:immunology*
chemical_list: D000199:Actins; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; C583413:erythroid differentiation regulator 1, human