title: Association between P-glycoprotein expression and response to chemotherapy in patients with osteosarcoma: a systematic and meta-analysis.
abstract: OBJECTIVE
  The aim was to investigate the association between p-glycoprotein (Pgp) expression and response to chemotherapy in patients with osteosarcoma.
  
  
  METHODS
  We searched and included the openly published articles evaluated the correlation between Pgp expression and response to chemotherapy. The odds ratio (OR) of response rate for Pgp positive group versus Pgp negative group was aggregated by random or fixed effect model.
  
  
  RESULTS
  Twelve studies were included in our meta-analysis. The mean Pgp positive rate was 0.39 ± 0.10 with its range of (0.14-0.53). The summary response rate was 0.46 ± 0.16 in Pgp positive and 0.57 ± 0.27 in the Pgp negative group, with no statistical difference between two groups (P > 0.05). The pooled OR of response rate for Pgp positive group versus Pgp negative group was 0.75 with its 95% confidence interval of 0.47-1.22, indicating there was no association between Pgp expression and response to chemotherapy in patients with osteosarcoma.
  
  
  CONCLUSIONS
  The present evidence indicated that there was no association between p-glycoprotein expression and chemotherapy response in patients with osteosarcoma.
authors.affiliation: Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Zhao
authors.forename: Fan
authors.initials: F
authors.lastname: Ding
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: De-Zhang
authors.initials: DZ
authors.lastname: Ma
authors.forename: Chang-Kun
authors.initials: CK
authors.lastname: Zheng
authors.affiliation: Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033, China.
authors.forename: Wu-Sheng
authors.initials: WS
authors.lastname: Kan
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy* / Q000235:genetics*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents