title: NAIP inflammasomes give the NOD to bacterial ligands.
abstract: NLRs are innate immune sensors that monitor the sanctity of the cytosolic compartment. In a recent paper in Molecular Cell, Tenthorey et al. reveal a novel ligand-sensing interface within regions of the oligomerization domain of the NAIPs, rather than within the leucine-rich repeats, as was anticipated.
authors.affiliation: Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Vivien I
authors.initials: VI
authors.lastname: Maltez
authors.affiliation: Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: emiao@med.unc.edu.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Miao
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D058847:Inflammasomes; D051616:Neuronal Apoptosis-Inhibitory Protein