title: A highly selective photoelectrochemical biosensor for uric acid based on core-shell Fe3O4@C nanoparticle and molecularly imprinted TiO2.
abstract: Combining the surface modification and molecular imprinting technique, a novel photoelectrochemical sensing platform with excellent photochemical catalysis and molecular recognition capabilities was established for the detection of uric acid based on the magnetic immobilization of Fe3O4@C nanoparticles onto magnetic glassy carbon electrode (MGCE) and modification of molecularly imprinted TiO2 film on Fe3O4@C. The developed biosensor was highly sensitive to uric acid in solutions, with a linear range from 0.3 to 34µM and a limit of detection of 0.02μM. Furthermore, the biosensor exhibited outstanding selectivity while used in coexisting systems containing various interferents with high concentration. The practical application of the biosensor was also realized for the selective detection of uric acid in spiked samples. The study made a successful attempt in the development of highly selective and sensitive photoelectrochemical biosensor for urine monitoring.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China; Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China.
authors.forename: Chunjing
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Electronic address: shihuisi2013@163.com.
authors.forename: Shihui
authors.initials: S
authors.lastname: Si
authors.affiliation: Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China.
authors.forename: Zhengpeng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D006801:Humans; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D054802:Molecular Imprinting; D014025:Titanium / Q000737:chemistry*; D014527:Uric Acid / Q000652:urine*
chemical_list: D058185:Magnetite Nanoparticles; C009495:titanium dioxide; D014527:Uric Acid; D014025:Titanium
keywords: Fe(3)O(4)@C; Magnetic electrode; Molecularly imprinted TiO(2); Photoelectrochemical biosensor; Uric acid