title: [Breast and ovarian cancer due to BRCA1&2 hereditary cancer predisposition syndrome and reproduction: literature review].
abstract: BACKGROUND
  Germline mutations BRCA1&2 are responsible in women for breast and ovarian cancers that commonly occur at a young age: as such, there are strong interactions between the oncological risks and the events of reproductive life, pregnancy, breastfeeding, and management of infertility.
  
  
  METHODS
  A review of the international literature from the PubMed database was conducted, and recommendations of French health agencies were exposed. Published studies are case-control and cohort studies in the majority, with a low level of evidence.
  
  
  RESULTS
  Pregnancy and lactation have no effect on breast and ovaries or even decreases the risk. The sex ratio among patients carrying the mutation is in favor of girls. It is not observed more infertility in patients carrying a mutation despite a strong suspicion of premature ovarian failure, and infertility treatments do not increase breast and ovarian risk. There are ethical debates concerning the place of pre-natal diagnosis: both experts and concerned patients recommend a case-by-case analysis of the requests.
authors.affiliation: Service de gynécologie obstétrique, CHU La Milétrie, 86000 Poitiers, France.
authors.forename: M
authors.initials: M
authors.lastname: Jégu
authors.affiliation: Service de gynécologie, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Some Der
authors.affiliation: Service de gynécologie, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France.
authors.forename: K
authors.initials: K
authors.lastname: Morcel
authors.affiliation: Service de génétique, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Abadie
authors.affiliation: Service de gynécologie obstétrique, CHU La Milétrie, 86000 Poitiers, France.
authors.forename: X
authors.initials: X
authors.lastname: Fritel
authors.affiliation: Service de gynécologie, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France. Electronic address: Jean.Leveque@chu-rennes.fr.
authors.forename: J
authors.initials: J
authors.lastname: Levêque
mesh_terms: D001942:Breast Feeding; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005298:Fertility / Q000502:physiology; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D013577:Syndrome
keywords: Allaitement maternel; BRCA; Breast and ovarian cancer; Breastfeeding; Cancer du sein et de l’ovaire; Diagnostic pré-implantatoire; Grossesse; Infertility; Infertilité; Pre-natal diagnosis; Pregnancy