title: Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.
abstract: Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.
authors.affiliation: Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada. dea.shahinas@utoronto.ca.
authors.forename: Dea
authors.initials: D
authors.lastname: Shahinas
authors.affiliation: Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada. atfolefo@ucalgary.ca.
authors.forename: Asongna
authors.initials: A
authors.lastname: Folefoc
authors.affiliation: Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada. drpillai@ucalgary.ca.
authors.forename: Dylan R
authors.initials: DR
authors.lastname: Pillai