title: Effects of in utero and lactational exposure to SbV on rat neurobehavioral development and fertility.
abstract: Meglumine antimoniate (MA) is a pentavalent antimony drug used to treat leishmaniases. We investigated the neurobehavioral development, sexual maturation and fertility of the offspring of MA-treated rats. Dams were administered MA (0, 75, 150, 300 mg Sb(V)/kg body wt/d, sc) from gestation day 0, throughout parturition and lactation, until weaning. At the highest dose, MA reduced the birth weight and the number of viable newborns. In the male offspring, MA did not impair development (somatic, reflex maturation, weight gain, puberty onset, open field test), sperm count, or reproductive performance. Except for a minor effect on body weight gain and vertical exploration in the open field, MA also did not affect the development of female offspring. Measurements of the Sb levels (ICP-MS) in the blood of MA-treated female rats and their offspring demonstrated that Sb is transferred to the fetuses via the placenta and to the suckling pups via milk.
authors.affiliation: Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: Deise R
authors.initials: DR
authors.lastname: Coelho
authors.affiliation: Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: Rosangela R
authors.initials: RR
authors.lastname: De-Carvalho
authors.affiliation: Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil.
authors.forename: Rafael C C
authors.initials: RC
authors.lastname: Rocha
authors.affiliation: Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil.
authors.forename: Tatiana D
authors.initials: TD
authors.lastname: Saint'Pierre
authors.affiliation: Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. Electronic address: paum@ensp.fiocruz.br.
authors.forename: Francisco J R
authors.initials: FJ
authors.lastname: Paumgartten
mesh_terms: D000818:Animals; D000965:Antimony / Q000378:metabolism; D000967:Antimony Sodium Gluconate / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D007774:Lactation; D008297:Male; D008536:Meglumine / Q000633:toxicity*; D000077485:Meglumine Antimoniate; D008892:Milk / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony; D000967:Antimony Sodium Gluconate
keywords: Antimony; Developmental toxicity; Kinetics; Leishmaniasis; Maternal milk; Metalloids; Pentavalent antimonial drugs; Reproductive toxicity