title: Morphological and ultrastructural effects of sodium fluoride toxicity on the liver of rat.
abstract: In the present investigation, the purpose was to investigate the fluoride induced histological and ultrastructural changes in the liver. The rats were given 10 mg NaF/kg bw/day for 30 days. Transmission electron microscopy revealed clumping of cytoplasmic organelles and extensive cytoplasmic degeneration in the hepatocytes. Extensive damages of mitochondria and rough endoplasmic reticulum were revealed in the treated rats. Reduction in the amount of glycogen was also observed. Disorganization of hepatic cells plates were observed using scanning electron microscopy. Changes in the liver cells of the treated rats observed under the light microscopic examination were degeneration of hepatic cords and cells and vacuolar degeneration of hepatic cells. The extensive degenerative changes seen in the liver cells due to fluoride may lead to decreased functioning of liver viz. urea formation and synthesis of proteins and their secretion.
authors.forename: Arbind
authors.initials: A
authors.lastname: Kumar
authors.forename: Mani Bhushan
authors.initials: MB
authors.lastname: Choudhary
mesh_terms: D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D051381:Rats; D012969:Sodium Fluoride / Q000633:toxicity*
chemical_list: D012969:Sodium Fluoride