title: Overexpression of SAMD9 suppresses tumorigenesis and progression during non small cell lung cancer.
abstract: The Sterile Alpha Motif Domain-containing 9 (SAMD9) gene has been recently emphasized during the discovery that it is expressed at a lower level in aggressive fibromatosis and some cases of breast and colon cancer, however, the underlying mechanisms are poorly understood. Here, we found that SAMD9 is down-regulated in human non-small cell lung cancer (NSCLC). Furthermore, knockdown of SAMD9 expression is increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. Finally, depletion of SAMD9 increases tumor formation in vivo. Our results may provide a strategy for blocking NSCLC tumorigenesis and progression.
authors.affiliation: Department of Oncology, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Oncology, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Oncology, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Ren
authors.affiliation: Department of Oncology, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Gong
authors.affiliation: Department of Oncology, General Hospital of Tianjin Medical University, Tianjin, China. Electronic address: zhongdsyx@126.com.
authors.forename: Dian-Sheng
authors.initials: DS
authors.lastname: Zhong
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000209:etiology / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D015536:Down-Regulation; D055785:Gene Knockdown Techniques; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009361:Neoplasm Invasiveness; D011506:Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C514443:SAMD9 protein, human
keywords: Carcinogenesis; Non small cell lung cancer; Progression; SAMD9