title: Oxidative stress in the oral cavity: sources and pathological outcomes.
abstract: Oxidative stress (OS), an imbalance in the oxidant-antioxidant equilibrium, is thought to be involved in the development of many seemingly unrelated diseases. Oral cavity tissues are a unique environment constantly exposed to internal and external compounds and material hazards as almost no other part of the human body. Some of the compounds are capable of generating OS. Here, the main groups of endogenous as well as exogenous OS sources are presented, followed by their oxidative effect on the salivary contents and function. The oxidative mechanisms in oral cells and their pathologic influence are also discussed.
authors.affiliation: Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, PO Box 9649, Haifa, Israel; Orthodontic and Craniofacial Department, Graduate School of Dentistry, Rambam Health Care Campus, PO Box 9602, Haifa, Israel.
authors.forename: Katia
authors.initials: K
authors.lastname: Avezov
authors.affiliation: Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, PO Box 9649, Haifa, Israel. Electronic address: Reznick@technion.ac.il.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Reznick
authors.affiliation: Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, PO Box 9649, Haifa, Israel; Orthodontic and Craniofacial Department, Graduate School of Dentistry, Rambam Health Care Campus, PO Box 9602, Haifa, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Aizenbud
mesh_terms: D005502:Food; D006801:Humans; D009055:Mouth / Q000502:physiology* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D012463:Saliva / Q000378:metabolism; D012907:Smoking / Q000503:physiopathology
keywords: Oral cavity; Oral pathology; Oxidative stress