title: Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T1 MRI contrast agent.
abstract: Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles were fabricated via the nanoscale acid-etching process from the solid MnO and Pt/MnO core/shell nanoparticles, respectively. In the synthesis, alkylphosphonic acid impurity in trioctylphosphine oxide was a key component, resulting in amorphous hollow metal phosphate nanoparticles. Hollow nanoparticles containing Mn(2+) ions showed positively enhanced T1 relaxation, in which the r1 values of the hollow MnOxPy and Pt/MnOxPy yolk/shell were greater than that of the original MnO nanocrystals. The increased surface area of the hollow nanoparticles enhanced interaction between Mn(2+) ions of the nanoparticle surface and water molecules. Cytotoxicity experiment revealed that Mn ions released from hollow walls of the MnOxPy nanoparticles were responsible for the cytotoxicity, while Pt ions from the Pt/MnOxPy yolk/shell were not released in the cells. These nanoparticles provide potential insights into an anticancer drug, enabling simultaneous T1 magnetic resonance imaging (MRI) and therapy.
authors.affiliation: School of Advanced Materials Engineering, Kookmin University, Jeungneung-ro 77, Seongbuk-gu, Seoul 136-702, Republic of Korea; School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Kwangjin
authors.initials: K
authors.lastname: An
authors.affiliation: Department of Chemical Engineering, Myongji University, Yongin, Gyeonggido 449-728, Republic of Korea.
authors.forename: Hyon Bin
authors.initials: HB
authors.lastname: Na
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Yong Il
authors.initials: YI
authors.lastname: Park
authors.affiliation: Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744, Republic of Korea.
authors.forename: Seung Hong
authors.initials: SH
authors.lastname: Choi
authors.affiliation: School of Materials Science and Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Republic of Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Son
authors.affiliation: School of Advanced Materials Engineering, Kookmin University, Jeungneung-ro 77, Seongbuk-gu, Seoul 136-702, Republic of Korea. Electronic address: nohyunlee@kookmin.ac.kr.
authors.forename: Nohyun
authors.initials: N
authors.lastname: Lee
mesh_terms: D002478:Cells, Cultured; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D019301:Oleic Acid; D008345:Manganese
keywords: Contrast agent; Cytotoxicity; MRI; Yolk/shell nanoparticle