title: Elastin peptides in aging and pathological conditions.
abstract: Elastin is the protein responsible for the resilience of vertebrate tissue. It is an extremely stable protein deposited during the early stages of life and experiencing almost no renewal. As a consequence, it can be considered that each individual has an elastin capital for life. Despite its extreme stability, elastin can be degraded by several enzymes termed elastases. Elastases are among the most aggressive proteases, and their presence is increased with age. As a consequence, elastin fragmentation resulting in the generation of elastin peptides is one of the hallmarks of aging. This review will examine their nature and further expose our current understanding of the role played by these peptides in aging and their contribution to tissue homeostasis and several pathologies.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Baud
authors.forename: Laurent
authors.initials: L
authors.lastname: Duca
authors.forename: Brigida
authors.initials: B
authors.lastname: Bochicchio
authors.forename: Bertrand
authors.initials: B
authors.lastname: Brassart
authors.forename: Nicolas
authors.initials: N
authors.lastname: Belloy
authors.forename: Antonietta
authors.initials: A
authors.lastname: Pepe
authors.forename: Manuel
authors.initials: M
authors.lastname: Dauchez
authors.forename: Laurent
authors.initials: L
authors.lastname: Martiny
authors.forename: Laurent
authors.initials: L
authors.lastname: Debelle
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D004194:Disease; D004549:Elastin / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D010455:Peptides / Q000378:metabolism*; D059748:Proteolysis
chemical_list: D010455:Peptides; D004549:Elastin