title: Metastasis occurring eleven years after diagnosis of human papilloma virus-related oropharyngeal squamous cell carcinoma.
abstract: Human papilloma virus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favourable prognosis, although approximately 20-25% of patients ultimately develop recurrent cancer. Most disease recurrence events appear within 3 years; however, long-term follow-up of reported studies are limited, and the risk of late recurrence is unknown. We present a case report of a patient who developed distant metastases of HPV-related SCC 11 years after initial diagnosis and treatment of HPV-related OPSCC. Late disease recurrence may occur after initial diagnosis of HPV-related OPSCC. This observation has implications on the appropriate duration of follow-up and surveillance of these patients.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Ley
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Wildes
authors.affiliation: Division of Surgical Pathology, Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Samir
authors.initials: S
authors.lastname: El-Mofty
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Adkins
keywords: human papilloma virus; oropharynx; p16