title: Eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a clinicopathologic disease of increasing prevalence. Because EoE is a chronic disease, its prevalence will continue to increase. Antigen triggers, including food and aeroallergens, drive eosinophilic and T helper cell type 2 inflammation, resulting in subepithelial fibrosis; this esophageal remodeling is the likely underlying pathogenesis for complications of narrowing, rigidity, and food impactions. Management includes dietary antigen elimination and topical corticosteroids. Long-term therapy and repeated endoscopy are often needed; consideration must be given to maintenance regimens and side effects. This review describes the clinical features, treatment options, epidemiology, and pathogenesis of EoE.
authors.affiliation: Department of Pediatrics and Medicine, Division of Allergy and Immunology, Center for Infection, Inflammation, and Immunology, 9500 Gilman Drive, MC-0760, La Jolla, CA 92093, USA. Electronic address: saceves@ucsd.edu.
authors.forename: Seema S
authors.initials: SS
authors.lastname: Aceves
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002648:Child; D004724:Endoscopy; D057765:Eosinophilic Esophagitis / Q000178:diet therapy / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004804:Eosinophils / Q000276:immunology*; D005355:Fibrosis / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000188:drug therapy / Q000276:immunology; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones; D007073:Immunoglobulin E; D011241:Prednisone
keywords: Clinical features; Eosinophilic esophagitis; Fibrosis; Pathogenesis; Remodeling; Treatment options