title: Ionic liquid mediated synthesis and molecular docking study of novel aromatic embedded Schiff bases as potent cholinesterase inhibitors.
abstract: Novel aromatic embedded Schiff bases have been synthesized in ionic liquid [bmim]Br and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activities. Among the newly synthesized compounds, 5f, 5h and 7j displayed higher AChE enzyme inhibitory activities than standard drug, galanthamine, with IC50 values of 1.88, 2.05 and 2.03μM, respectively. Interestingly, all the compounds except for compound 5c displayed higher BChE inhibitories than standard with IC50 values ranging from 3.49 to 19.86μM. Molecular docking analysis for 5f and 7j possessing the most potent AChE and BChE inhibitory activities, disclosed their binding interaction templates to the active site of AChE and BChE enzymes, respectively.
authors.affiliation: School of Chemical Sciences, University Sains Malaysia, Minden, 11800 Penang, Malaysia; College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq.
authors.forename: Basma M
authors.initials: BM
authors.lastname: Abd Razik
authors.affiliation: School of Chemical Sciences, University Sains Malaysia, Minden, 11800 Penang, Malaysia. Electronic address: osman.hasnah2012@yahoo.com.
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia. Electronic address: alirezaa.basiri@gmail.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Basiri
authors.affiliation: School of Chemical Sciences, University Sains Malaysia, Minden, 11800 Penang, Malaysia.
authors.forename: Abdussalam
authors.initials: A
authors.lastname: Salhin
authors.affiliation: School of Chemical Sciences, University Sains Malaysia, Minden, 11800 Penang, Malaysia.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Kia
authors.affiliation: Center for Drug Research, University Sains Malaysia, Minden, 11800 Penang, Malaysia.
authors.forename: Mohammed Oday
authors.initials: MO
authors.lastname: Ezzat
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia.
authors.forename: Vikneswaran
authors.initials: V
authors.lastname: Murugaiyah
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology; D000818:Animals; D002091:Butyrylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D052578:Ionic Liquids / Q000737:chemistry*; D062105:Molecular Docking Simulation; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014101:Torpedo
chemical_list: D002800:Cholinesterase Inhibitors; D006841:Hydrocarbons, Aromatic; D052578:Ionic Liquids; D012545:Schiff Bases; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: AChE and BChE; Galanthamine; Ionic liquids; Schiff base