title: Mitochondrial pyruvate import and its effects on homeostasis.
abstract: Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.
authors.affiliation: Department of Cell Biology, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.
authors.forename: Benoît
authors.initials: B
authors.lastname: Vanderperre
authors.affiliation: Department of Cell Biology, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.
authors.forename: Tom
authors.initials: T
authors.lastname: Bender
authors.affiliation: Mitochondrial Biology Unit, Medical Research Council, Cambridge CB2 0XY, United Kingdom.
authors.forename: Edmund R S
authors.initials: ER
authors.lastname: Kunji
authors.affiliation: Department of Cell Biology, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland. Electronic address: jean-claude.martinou@unige.ch.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Martinou
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D051336:Mitochondrial Membranes / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D019289:Pyruvic Acid / Q000378:metabolism*
chemical_list: C573718:MPC1 protein, human; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D027501:Monocarboxylic Acid Transporters; D019289:Pyruvic Acid; D005947:Glucose