title: Adverse events after treatment of patients with acute limb ischemia.
abstract: BACKGROUND
  To assess the outcome and the occurrence and consequences of adverse events (AEs) after treatment of acute limb ischemia (ALI).
  
  
  METHODS
  Retrospective analysis on intra-arterial thrombolysis (group I) and thromboembolectomy (group II). Outcome measures were primary patency and limb salvage rates. AEs and consequences were registered during admission and 30 days after discharge.
  
  
  RESULTS
  A total of 238 procedures were included (group I, 173 vs. group II, 65). The primary patency (P = 0.144) and limb salvage rates (P = 0.166) were not significantly different between both groups. A total of 195 AEs were registered. Most AEs were procedure related and resulted in surgical reintervention (77% vs. 76%). Some AEs resulted in irreversible physical damage (15% vs. 25%) and death (6% vs. 12%).
  
  
  CONCLUSIONS
  Both, intra-arterial thrombolysis and thromboembolectomies are adequate therapies; however, they result in a wide variety of AEs resulting in serious morbidity and even death.
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands. Electronic address: JvanderSlegt@amphia.nl.
authors.forename: Jasper
authors.initials: J
authors.lastname: van der Slegt
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands.
authors.forename: Hans C
authors.initials: HC
authors.lastname: Flu
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands.
authors.forename: Eelco J
authors.initials: EJ
authors.lastname: Veen
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands.
authors.forename: Gwan H
authors.initials: GH
authors.lastname: Ho
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands.
authors.forename: Hans G W
authors.initials: HG
authors.lastname: de Groot
authors.affiliation: Department of Radiology, Amphia Hospital, Breda, The Netherlands.
authors.forename: Louwerens D
authors.initials: LD
authors.lastname: Vos
authors.affiliation: Department of Surgery, Amphia Hospital, Breda, The Netherlands.
authors.forename: Lijckle
authors.initials: L
authors.lastname: van der Laan
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D017128:Embolectomy / Q000009:adverse effects* / Q000401:mortality; D005121:Extremities / Q000098:blood supply*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D017131:Thrombectomy / Q000009:adverse effects* / Q000401:mortality; D015912:Thrombolytic Therapy / Q000009:adverse effects* / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency / Q000187:drug effects
chemical_list: D005343:Fibrinolytic Agents