title: Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells.
abstract: Mammalian hearts carry a number of primitive stem cell-like populations, although the magnitude of their contribution to tissue homeostasis and repair remains controversial. Recent CRE recombinase-based lineage tracing experiments suggest only a minor contribution to the formation of new cardiomyocytes from such cells, albeit one that might be augmented therapeutically. As the field explores clinical translation of cardiac stem cells, it will be important to understand the biology of these cells in great detail. In this review we document the various reported stem and progenitor cell populations in mammalian hearts and discuss the current state of knowledge on their origins and lineage capabilities.
authors.affiliation: Department of Cardiology, Westmead Hospital, Hawkesbury and Darcy Rds., Westmead 2145, New South Wales, Australia; School of Medicine, University of Sydney, 2006, Australia; Centre for Heart Research, Westmead Millennium Institute for Medical Research, Hawkesbury Rd, Westmead 2145, New South Wales, Australia; Stem Cells Australia, Melbourne Brain Centre, The University of Melbourne, 3010 Victoria, Australia.
authors.forename: James J H
authors.initials: JJ
authors.lastname: Chong
authors.affiliation: Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St., Darlinghurst 2010, New South Wales, Australia.
authors.forename: Elvira
authors.initials: E
authors.lastname: Forte
authors.affiliation: Stem Cells Australia, Melbourne Brain Centre, The University of Melbourne, 3010 Victoria, Australia; Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St., Darlinghurst 2010, New South Wales, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, New South Wales, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, New South Wales, Australia. Electronic address: r.harvey@victorchang.edu.au.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Harvey
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D006321:Heart / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology*