title: Association of the C-type lectin-like domain family-16A (CLEC16A) gene polymorphisms with acute coronary syndrome in Mexican patients.
abstract: The CLEC16A gene has an important role in the immune activation and regulation inflammatory. This gene encodes to C-type lectin domain that is involved in the recognition of DAMPS. The aim of this study was assess the CLEC16A gene polymorphisms in the risk of developing ACS in a group of patients. Four rs12708716, rs12917716, rs6498142 and rs9925481 (positions 146529 A>G, 155804 G>C, 47905 C>G and 64135 C>T, respectively) single nucleotide polymorphisms of CLEC16A gene were analyzed by TaqMan assays in a group of 452 patients with ACS and 456 healthy controls. The analysis was performed on the total group of individuals and then in groups of men and women separately. Under co-dominant model adjusted by cardiovascular risk factors the rs12708716 (146529 A>G) and rs12917716 (155804 G>C) polymorphisms were significantly associated with decrease risk of ACS in men (OR=0.16, PCo-dom=0.027 and OR=0.37, PCo-dom=0.016, respectively). In summary, our data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men.
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcon
authors.affiliation: Laboratory of Genomic Medicine, Unit of Research, Hospital Juárez de Mexico, Mexico City, Mexico.
authors.forename: Julian
authors.initials: J
authors.lastname: Ramirez-Bello
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Angeles-Martinez
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Rodriguez-Perez
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Nonanzit
authors.initials: N
authors.lastname: Perez-Hernandez
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Wendy Angelica
authors.initials: WA
authors.lastname: Ocampo-Arcos
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Obil-Chavarria
authors.affiliation: Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: mfragoso1275@yahoo.com.mx.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Fragoso
mesh_terms: D054058:Acute Coronary Syndrome / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D000368:Aged; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics* / Q000276:immunology; D008297:Male; D008800:Mexico; D008875:Middle Aged; D008957:Models, Genetic; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: C522505:CLEC16A protein, human; D037181:Lectins, C-Type; D009004:Monosaccharide Transport Proteins
keywords: Acute coronary syndrome; C-type lectin-like domain family 16A (CLEC16A); Genetic polymorphisms; Susceptibility