title: Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates.
abstract: Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6')-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(')-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.
authors.affiliation: Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong, People's Republic of China. Electronic address: plho@hkucc.hku.hk.
authors.forename: Pak-Leung
authors.initials: PL
authors.lastname: Ho
authors.affiliation: Department of Clinical Pathology, Princess Margaret Hospital, Hospital Authority, Hong Kong, People's Republic of China.
authors.forename: Lai-Ming
authors.initials: LM
authors.lastname: Leung
authors.affiliation: Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Kin-Hung
authors.initials: KH
authors.lastname: Chow
authors.affiliation: Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Eileen L
authors.initials: EL
authors.lastname: Lai
authors.affiliation: Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Wai-U
authors.initials: WU
authors.lastname: Lo
authors.affiliation: Department of Clinical Pathology, Princess Margaret Hospital, Hospital Authority, Hong Kong, People's Republic of China.
authors.forename: Tak-Keung
authors.initials: TK
authors.lastname: Ng
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D006723:Hong Kong; D006801:Humans; D015995:Prevalence; D062606:Tertiary Care Centers; D012359:tRNA Methyltransferases / Q000235:genetics*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012359:tRNA Methyltransferases; D000123:Acetyltransferases
keywords: aminoglycoside resistance; molecular epidemiology; multidrug resistance