title: The variant rs8048002 T>C in intron 3 of the MHC2TA gene is associated with risk of developing acute coronary syndrome.
abstract: Recently, an intronic single nucleotide polymorphism (rs8048002) in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to several inflammatory diseases. The aim of the present study was to test for an association between this MHC2TA gene polymorphism and susceptibility to the risk of developing acute coronary syndromes (ACS) in a group of Mexicans patients. The single nucleotide polymorphism (rs8048002) of the MHC2TA gene was analyzed by 5' exonuclease TaqMan genotyping assays in a group of 452 patients with ACS and 456 healthy controls. The C allele and TC genotype were associated with risk of developing ACS (OR=4.55, pC=6×10(-4) and OR=4.41, pC=1.5×10(-3), respectively). Multiple logistic analysis was used for estimate risk between ACS patients and controls adjusted by cardiovascular risk factors (gender, age, hypertension, dyslipidemia, smoking, diabetes, body mass index and alcohol consumption). In this analysis, the TC+CC genotypes were significantly associated with increased risk of ACS as compared to TT genotype (OR=4.56, pC=0.004). In summary, our data suggest that the MHC2TA rs8048002 C>T gene polymorphism plays an important role in the risk of developing ACS.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Group Study of Atherosclerosis, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.affiliation: Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Roció
authors.initials: R
authors.lastname: Martínez-Alvarado
authors.affiliation: Coronary Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Group Study of Atherosclerosis, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Héctor
authors.initials: H
authors.lastname: González-Pacheco
authors.affiliation: Coronary Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Group Study of Atherosclerosis, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Martínez-Sánchez
authors.affiliation: Department of Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.affiliation: Epidemiology and Health Service Research Unit, Ageing Area, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.
authors.forename: Teresa
authors.initials: T
authors.lastname: Juarez-Cedillo
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Silvestre
authors.initials: S
authors.lastname: Ramirez-Fuentes
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Group Study of Atherosclerosis, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Group Study of Atherosclerosis, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: mfragoso1275@yahoo.com.mx.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
mesh_terms: D054058:Acute Coronary Syndrome; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015534:Trans-Activators / Q000235:genetics*
chemical_list: C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators
keywords: Acute coronary syndrome; Genetic susceptibility; Major histocompatibility complex class II trans-activator (MHC2TA); Polymorphism