title: Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging.
abstract: Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributing to age-dependent cognitive decline and our susceptibility to Alzheimer's disease. It appears that both the duration of metabolic condition and the age of the individual, together can contribute to the potential impact on peripheral as well as brain health. Because of robust evidence that in animal models of aging, Ca(2+) dysregulation alters neuronal health, synaptic plasticity, and learning and memory processes, we tested the hypothesis that peripheral metabolic dysregulation could exacerbate Ca(2+) dysfunction in hippocampal CA1 neurons. Using intracellular/ extracellular electrophysiological and Ca(2+) imaging techniques, we show that Ca(2+)levels at rest or during synaptic stimulation, the Ca(2+)-dependent afterhyperpolarization, baseline field potentials, and short-term synaptic plasticity were not significantly altered in young-adult male Zucker diabetic fatty rats compare to their lean counterparts. Our observations suggest that early phases of T2DM characterized by high levels of glucose and insulin may be too transient to alter hippocampal CA1 physiology in this animal model of diabetes. These results are supported by clinical data showing that longer T2DM duration can have greater negative impact on cognitive functions. This article is part of a Special Issue entitled SI: Brain and Memory.
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Shaniya
authors.initials: S
authors.lastname: Maimaiti
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: DeMoll
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Katie L
authors.initials: KL
authors.lastname: Anderson
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Ryan B
authors.initials: RB
authors.lastname: Griggs
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Bradley K
authors.initials: BK
authors.lastname: Taylor
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA.
authors.forename: Nada M
authors.initials: NM
authors.lastname: Porter
authors.affiliation: University of Kentucky Medical Center, Department of Pharmacology and Nutritional Sciences; Department of Physiology, 800 Rose Street, UKMC-MS313, Lexington, Kentucky 40536, USA. Electronic address: othibau@uky.edu.
authors.forename: Olivier
authors.initials: O
authors.lastname: Thibault
mesh_terms: D000200:Action Potentials; D000375:Aging; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D056547:CA1 Region, Hippocampal / Q000378:metabolism* / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D019706:Excitatory Postsynaptic Potentials; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000378:metabolism*; D051381:Rats
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002118:Calcium; D006442:Glycated Hemoglobin; D007328:Insulin
keywords: Aging; Calcium; Diabetes; Imaging; Learning; Obesity