title: Effect of porcine circovirus type 2 (PCV2) load in serum on average daily weight gain during the postweaning period.
abstract: Porcine circovirus type 2 (PCV2) is a ubiquitous virus that mainly affects nursery and fattening pigs causing systemic disease (PCV2-SD) or subclinical infection. A characteristic sign in both presentations is reduction of average daily weight gain (ADWG). The present study aimed to assess the relationship between PCV2 load in serum and ADWG from 3 (weaning) to 21 weeks of age (slaughter) (ADWG 3-21). Thus, three different boar lines were used to inseminate sows from two PCV2-SD affected farms. One or two pigs per sow were selected (60, 61 and 51 piglets from Pietrain, Pietrain×Large White and Duroc×Large White boar lines, respectively). Pigs were bled at 3, 9, 15 and 21 weeks of age and weighted at 3 and 21 weeks. Area under the curve of the viral load at all sampling times (AUCqPCR 3-21) was calculated for each animal according to standard and real time quantitative PCR results; this variable was categorized as "negative or low" (<10(4.3) PCV2 genome copies/ml of serum), "medium" (≥10(4.3) to ≤10(5.3)) and "high" (>10(5.3)). Data regarding sex, PCV2 antibody titre at weaning and sow parity was also collected. A generalized linear model was performed, obtaining that paternal genetic line and AUCqPCR 3-21 were related to ADWG 3-21. ADWG 3-21 (mean±typical error) for "negative or low", "medium" and "high" AUCqPCR 3-21 was 672±9, 650±12 and 603±16 g/day, respectively, showing significant differences among them. This study describes different ADWG performances in 3 pig populations that suffered from different degrees of PCV2 viraemia.
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain. Electronic address: sergio.lopez@cresa.uab.cat.
authors.forename: S
authors.initials: S
authors.lastname: López-Soria
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sibila
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Nofrarías
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Calsamiglia
authors.affiliation: Departament de Ciència Animal i dels Aliments, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
authors.forename: E G
authors.initials: EG
authors.lastname: Manzanilla
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
authors.forename: H
authors.initials: H
authors.lastname: Ramírez-Mendoza
authors.affiliation: Swine Veterinarians, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Mínguez
authors.affiliation: Swine Veterinarians, Valencia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Serrano
authors.affiliation: Swine Veterinarians, Valencia, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Marín
authors.affiliation: Merial S.A.S., BP 7123, 69348 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Joisel
authors.affiliation: Merial S.A.S., BP 7123, 69348 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Charreyre
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain; Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D058345:Asymptomatic Infections; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000502:physiology*; D005260:Female; D016014:Linear Models; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D019562:Viral Load; D014766:Viremia / Q000662:veterinary; D014886:Weaning; D015430:Weight Gain
chemical_list: D000914:Antibodies, Viral
keywords: Average daily weight gain; Genetics; PCV2-subclinical infection (PCV2-SI); PCV2-systemic disease (PCV2-SD); Porcine circovirus type 2 (PCV2); Viral load