title: The long-term efficacy of Chinese hamster ovary cell derived hepatitis B vaccine after being used for 14-16 years in Chinese rural communities.
abstract: OBJECTIVE
  To evaluate the long-term efficacy of Chinese hamster ovary (CHO) cell derived hepatitis B vaccine after being used for 14-16 years in country community in Hebei province in China.
  
  
  METHODS
  A cross-sectional investigation was carried out in 3 of 7 randomly selected rural communities in Zhengding County in 2013. The children who were born between 1997 and 1999 and were vaccinated with three doses of CHO-derived hepatitis B vaccine were eligible to participate in the study. Their sera samples were tested for HBV serological markers. For HBsAg positive children, their historical results were compared, in order to see whether these were new infections.
  
  
  RESULTS
  Among the 920 participating children, the prevalence of HBsAg, anti-HBs and anti-HBc were 0.65%, 73.15% and 1.20% respectively. The differences between birth-year groups were not significant. When compared with baseline, the vaccine efficacy was 94.2% and the anti-HBs titers of 668 children with sole anti-HBs positivity were 178.8 mI U/ml. By comparing with historical data, no new infection was found in this latest survey. Among 6 mothers of HBsAg positive children, 4 were HBsAg positive, 1 was negative and 1 was unknown.
  
  
  CONCLUSIONS
  The long-term efficacy of the CHO derived hepatitis vaccine is good and stable for 14-16 years after vaccination. A booster dose seems not necessary. Implementing mother-newborn blocking measures for newborns from HBsAg carrier mothers is urgently needed in the future.
authors.affiliation: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing 102206, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Hebei Province Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Jingchen
authors.initials: J
authors.lastname: Ma
authors.affiliation: Zhengding County Center for Disease Control and Prevention, Zhengding 050800, PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Hao
authors.affiliation: Zhengding County Center for Disease Control and Prevention, Zhengding 050800, PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Zhengding County Center for Disease Control and Prevention, Zhengding 050800, PR China.
authors.forename: Xinjiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Hebei Province Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing 102206, PR China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Bi
authors.affiliation: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing 102206, PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Shen
authors.affiliation: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing 102206, PR China. Electronic address: qiufeng615@sina.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.affiliation: Hebei Province Center for Disease Control and Prevention, Shijiazhuang 050021, PR China. Electronic address: yuliang_zh@163.com.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000818:Animals; D016466:CHO Cells; D002353:Carrier State / Q000276:immunology; D002681:China / Q000453:epidemiology; D006224:Cricetinae; D003412:Cricetulus; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006801:Humans; D008297:Male; D012424:Rural Population; D013997:Time Factors; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: Children; Chinese hamster ovary cell; Hepatitis B vaccination; Hepatitis B virus; Long-term efficacy; Neonates