title: [Vasculogenic mimicry in laryngeal squamous cell carcinoma and its clinicopathological significance].
abstract: The present paper aims to investigate whether or not vasculogenic mimicry (VM) exists in laryngeal squamous cell carcinoma (LSCC), and to elucidate its relationship to microvessel density (MVD), galectin-3 (Gal-3) expression, and clinicopathological factors of patients with LSCC. VM, score of MVD and expression of Gal-3 protein were detected by immunohistochemistry and histochemistry in 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue. The positive rate of VM in normal laryngeal tissues was 0%, and was 33.7% in LSCC tissues. There was a significant difference between the two groups (P<0. 01). VM or MVD was significantly related to differentiation, pTNM stages and lymph node metastasis of LSCC (P<0.05), but not to age, gender and tumor site (P>0. 05). And there was a positive correlation between every two of VM, score of MVD, and Gal-3 protein (P< 0. 05). The results suggest that expression of Gal-3 protein may be related to the initiation, angiogenesis and VM formation in LSCC; And VM, angiogenesis and Gal-3 protein may be involved in the development, invasion and metastasis of LSCC.
authors.forename: Shiwu
authors.initials: S
authors.lastname: Wu
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Zenong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Danna
authors.initials: D
authors.lastname: Wang
mesh_terms: D001798:Blood Proteins; D002294:Carcinoma, Squamous Cell / Q000098:blood supply*; D037502:Galectin 3 / Q000378:metabolism; D037161:Galectins; D006258:Head and Neck Neoplasms / Q000098:blood supply*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000098:blood supply*; D008207:Lymphatic Metastasis; D009389:Neovascularization, Pathologic; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human