title: Subspecialization in the human posterior medial cortex.
abstract: The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by forward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left inferior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-unconstrained but not task-constrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: Danilo
authors.initials: D
authors.lastname: Bzdok
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Heeger
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Langner
authors.affiliation: Dept. of Physics, FL International University, USA.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Palomero-Gallagher
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; Cingulum NeuroSciences Institute and Boston University School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA.
authors.forename: Brent A
authors.initials: BA
authors.lastname: Vogt
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address: S.Eickhoff@fz-juelich.de.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
mesh_terms: D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D003198:Computer Simulation; D063132:Connectome / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008953:Models, Anatomic; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
keywords: Connectivity-based parcellation; Default mode network; Functional decoding; Parietal lobe; Posterior cingulate cortex; Retrosplenial cortex; Statistical learning