title: Quantitative magnetic resonance imaging of the articular cartilage of the knee joint.
abstract: Osteoarthritis is characterized by a decrease in the proteoglycan content and disruption of the highly organized collagen fiber network of articular cartilage. Various quantitative magnetic resonance imaging techniques have been developed for noninvasive assessment of the proteoglycan and collagen components of cartilage. These techniques have been extensively used in clinical practice to detect early cartilage degeneration and in osteoarthritis research studies to monitor disease-related and treatment-related changes in cartilage over time. This article reviews the role of quantitative magnetic resonance imaging in evaluating the composition and ultrastructure of the articular cartilage of the knee joint.
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA. Electronic address: rkijowski@uwhealth.org.
authors.forename: Richard
authors.initials: R
authors.lastname: Kijowski
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Chaudhary
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D024022:Fibrillar Collagens / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D020370:Osteoarthritis, Knee / Q000378:metabolism / Q000473:pathology*; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D015415:Biomarkers; D024022:Fibrillar Collagens; D011509:Proteoglycans
keywords: Cartilage; Collagen; Magnetic resonance imaging; Proteoglycan; Quantitative; Review