title: The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population.
abstract: BACKGROUND
  The cyclooxygenase-2 (cox-2) pathway is now recognized to be important in human cancer development and progression. The gene for cox-2 carries a common single nucleotide polymorphism, T8473C, located within a potential functional region in the 3'-UTR of cox-2 gene was identified. We have investigated the frequencies of cox-2 genotypes in Tunisian population to determine whether that polymorphism was associated with the risk of nasopharyngeal carcinoma (NPC) in Tunisian population.
  
  
  METHODS
  One hundred and eighty-nine NPC patients were compared to 237 healthy controls.
  
  
  RESULTS
  The cox-2 T8473C polymorphism was significantly associated with NPC (P=0.031). The CC-genotype and C allele were more frequent in control compared to patients group [CC: OR=0.37; P=0.013; 95% CI: 0.17-0.81; C: OR=0.72; P=0.032; 95% CI: 0.53-0.97]. Multivariate logistic regression analyses revealed that the CC-genotype was associated with a significantly decreased risk of NPC (P=0.013). Tumor sizes, histologic grade, presence of primary lymph node metastases, age or sex were not associated with cox-2 genotypes.
  
  
  CONCLUSIONS
  We conclude that the CC-genotype and C allele of cox-2 T8473C gene polymorphism are associated with decreased risk of nasopharyngeal carcinoma in a Tunisian population.
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia. Electronic address: tesnim.mamoghli@yahoo.fr.
authors.forename: T
authors.initials: T
authors.lastname: Mamoghli
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Douik
authors.affiliation: Laboratory of Biochemistry, UR "Human Nutrition and Metabolic Disorders", Faculty of Medicine, Avicenne Street, 5019 Monastir, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Mehri
authors.affiliation: Clinical biology department, Center of Traumatology and burns, 1st May Street, 2063 Ben Arous, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Ghanem
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Ben Chaabane
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: J
authors.initials: J
authors.lastname: Bouassida
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: G
authors.initials: G
authors.lastname: Kablouti
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: L
authors.initials: L
authors.lastname: Harzallah
authors.affiliation: Institut of Carcinology, Salah Azaiz, O.R.L. Department, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Gritli
authors.affiliation: Clinical Biology Department, Institut of Carcinology Salah Azaiz, boulevard du 9 Avril, Bab Saadoun, 1006 Tunis, Tunisia.
authors.forename: F
authors.initials: F
authors.lastname: Guemira
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: Association; Cancer du nasopharynx; Cox-2; Cyclooxygénase-2; Nasopharyngeal carcinoma; Polymorphisme T8473C; T8473C polymorphism