title: Corpora amylacea in the neocortex in patients with temporal lobe epilepsy and focal cortical dysplasia.
abstract: BACKGROUND
  Corpora amylacea (CoA) are present in about 60% of atrophic hippocampi resected from patients with drug resistant temporal lobe epilepsy (DRTLE). They have also been described in the lateral temporal neocortex, although less frequently.
  
  
  OBJECTIVE
  The objective is to measure the presence, distribution and density of CoA in the lateral temporal lobes of patients with DRTLE and focal cortical dysplasia (FCD), also examining how CoA density may be linked to demographic and clinical traits.
  
  
  METHODS
  Resected tissue from 35 patients was analysed. CoA density was assessed with a semi-quantitative scale according to the criteria established by Cherian et al.
  
  
  RESULTS
  Presence of CoA in the neocortex of 9 patients was associated with hippocampal sclerosis (FCD type iiia, 7 cases), disembryoplastic neuroepithelial tumour (FCD type iiib, 1 case), and cavernous angioma (FCD type iiic, 1 case). The meningeal surface (MS) was involved in all cases, and 8 cases displayed CoA in the cerebral parenchyma (white matter) and around blood vessels. CoA density on the MS showed a negative correlation with age at seizure onset (r = -0.828, P<.05) and a positive correlation with disease duration (r = 0.678, P<.05) but not with postoperative clinical outcome.
  
  
  CONCLUSIONS
  Patients with DRTLE and a primary lesion (hippocampal sclerosis, tumour, vascular malformation) associated with mild FCD were shown to have CoA deposits in the neocortex. No association was found between presence of CoA and clinical outcome one year after surgery.
authors.affiliation: Laboratorio de Anatomía Patológica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. Electronic address: baby@neuro.ciren.cu.
authors.forename: B O
authors.initials: BO
authors.lastname: Estupiñán-Díaz
authors.affiliation: Servicio de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: L M
authors.initials: LM
authors.lastname: Morales-Chacón
authors.affiliation: Servicio de Neurocirugía, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: I
authors.initials: I
authors.lastname: García-Maeso
authors.affiliation: Laboratorio de Neuroinmunología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: L
authors.initials: L
authors.lastname: Lorigados-Pedre
authors.affiliation: Servicio de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: M
authors.initials: M
authors.lastname: Báez-Martín
authors.affiliation: Departamento de Neuropsicología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: M E
authors.initials: ME
authors.lastname: García-Navarro
authors.affiliation: Servicio de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: O
authors.initials: O
authors.lastname: Trápaga-Quincoses
authors.affiliation: Servicio de Neurocirugía, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: N
authors.initials: N
authors.lastname: Quintanal-Cordero
authors.affiliation: Servicio de Neurocirugía, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: J
authors.initials: J
authors.lastname: Prince-López
authors.affiliation: Servicio de Neurología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
authors.forename: J E
authors.initials: JE
authors.lastname: Bender-del Busto
mesh_terms: D000328:Adult; D000069279:Drug Resistant Epilepsy; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000473:pathology*; D008875:Middle Aged; D019579:Neocortex / Q000473:pathology*; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology; D055815:Young Adult
keywords: Clinical outcome; Corpora amylacea; Cuerpos amiláceos; Displasia cortical focal; Drug-resistant; Epilepsia del lóbulo temporal; Evolución clínica; Farmacorresistencia; Focal cortical dysplasia; Histopathology; Histopatología; Temporal lobe epilepsy