title: [Activity and results of liver transplantation in Spain during 1984-2012. Analysis of the Spanish Liver Transplant Registry].
abstract: OBJECTIVE
  Liver transplantation (LT) is a proven effective treatment of severe liver disease. The aim of this paper is to analyze the results of LT in Spain during the period 1984-2012.
  
  
  METHODS
  We analyze the results of the database of Spanish Liver Transplant Registry.
  
  
  RESULTS
  A total of 20,288 transplants were performed in 18,568 patients. The median age of the donor and recipient increased during the analysis period: 25 years (95% confidence interval [95% CI] 18-40) and 47 years (95% CI 34-55), respectively, in the period 1984-1994 compared to 59 years (95% CI 33-65; P<.05) and 55 years (95% CI 48-61; P<.01), respectively, in the period 2010-2012. The most frequent indications were liver cirrhosis (63.18%) and hepatocellular carcinoma (19.62%). The overall patient and graft survival was respectively 85.1 and 77.8% in the first year, 72.6 and 63.5% the fifth year and 62 and 52.6% in the tenth year. First year patients and graft survival increased respectively from 77.8 and 66.3% in the period 1984-1994 to 88.5 and 83% in 2010-2012 (P<.01). Donor and recipient age, etiology of underlying disease, and hepatitis C virus serological status, were factors associated with decreased survival in univariate and multivariate analysis.
  
  
  CONCLUSIONS
  Results of LT improved significantly over the review period, despite a progressive increase in donor and recipient age.
authors.affiliation: Unidad de Trasplante Hepático, Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España. Electronic address: valentin.cuervasmons@uam.es.
authors.forename: Valentín
authors.initials: V
authors.lastname: Cuervas-Mons
authors.affiliation: Organización Nacional de Trasplantes, Madrid, España.
authors.forename: Gloria
authors.initials: G
authors.lastname: de la Rosa
authors.affiliation: Servicio de Cirugía Hepatobiliopancreática y Trasplante Hepático, Clínica Universitaria Navarra, Pamplona, Navarra, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pardo
authors.affiliation: Unidad de Cirugía y Trasplante Hepático, Hospital Universitario La Fe, Valencia, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: San Juan
authors.affiliation: Unidad de Cirugía Hepática y Trasplante, Hospital Universitario de Cruces, Barakaldo, Bizkaia, España.
authors.forename: Andrés
authors.initials: A
authors.lastname: Valdivieso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008107:Liver Diseases / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data / Q000639:trends*; D008297:Male; D008875:Middle Aged; D012042:Registries; D013030:Spain; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cirrhosis; Cirrosis; Liver transplantation; Resultados; Results; Supervivencia; Survival; Trasplante hepático