title: Targeted Screening and Quantification of dl-PCBs and Dioxins in Various Foodstuffs by Programmed-temperature Vaporizer Large-volume Injection Coupled to GC-MS.
abstract: In 2009, high concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) were found in soils located near the municipal garbage incinerator of Geneva. The matter of food contamination in this area was raised. Based on exposure criteria, a strategy of analysis of animal fats has been established with farmers in the Geneva area. Most methods of analysis of dl-PCBs, dioxins and furans, are based on gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS) and considered as the reference methodology. An innovative approach was developed by programmed-temperature vaporizer large-volume injection (PTV-LV) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) analysis. This analytical method was validated and was found suitable for screening and quantification of target compounds in animal fats (beef, pork, sheep, etc. ). PTV-LV coupled to GC-MS/MS appeared to be a good alternative compared to the GC-HRMS strategy, offering a good compromise between sensitivity, versatility of instrumentation, and economical aspects. A survey of 121 samples was conducted.
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland. ngoc-huy.ho@etat.ge.ch.
authors.forename: Ngoc Huy
authors.initials: NH
authors.lastname: Ho
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bugey
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Zimmerli
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Nançoz
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland.
authors.forename: Didier
authors.initials: D
authors.lastname: Ortelli
authors.affiliation: Official Food and Veterinary Control Authority of Geneva, Quai Ernest-Ansermet 22, CH-1205 Geneva, Switzerland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Edder
mesh_terms: D000818:Animals; D004147:Dioxins / Q000032:analysis*; D005506:Food Contamination; D008401:Gas Chromatography-Mass Spectrometry; D008460:Meat; D009330:Nebulizers and Vaporizers; D000072317:Polychlorinated Dibenzodioxins; D000069466:Red Meat; D012756:Sheep; D053719:Tandem Mass Spectrometry; D013696:Temperature
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins