title: M. paratuberculosis and Parkinson's disease--is this a trigger.
abstract: Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP has been linked to other inflammatory diseases: sarcoidosis, Blau syndrome, autoimmune diabetes, autoimmune thyroiditis and multiple sclerosis. Genetic studies reveal an association between Parkinson's disease (PD), leprosy and Crohn's disease and since discovered, these findings have been considered "surprising". Autophagy and ubiquitin-proteosome systems are cellular systems that both fight intracellular pathogens (xenophagy) and maintain cellular protein quality control. PD is a common neurodegenerative disease that manifests clinically as a profound movement disorder. The recognized genetic defects of PD create disruption of cellular homeostasis that result in protein folding abnormalities of PD called Lewy bodies. Those same genetic defects are associated with susceptibility to intracellular pathogens, including mycobacteria. It is now understood that PD Lewy body pathology starts in the enteric nervous system and "spreads" to the brain in a retrograde fashion via the vagus nerve. This is the same process by which prions affect the brain. Lewy body pathology of the enteric nervous system predates the Lewy body pathology of the central nervous system (CNS) by years or even decades. This article proposes that genetic defects associated with PD also result in a permissive environment for MAP infection--ineffective xenophagy. It postulates that beginning as an enteric infection, MAP--via the vagus nerve--initiates a pathologic process that results in a targeted neuroinvasion of the CNS. The article proposes that MAP infection and resultant PD pathology are due, in the genetically at-risk and age dependant, to the consumptive exhaustion of the protein quality control systems.
authors.affiliation: McPherson Eye Research Institute, University of Wisconsin-Madison, 9431 WIMR, 1111 Highland Avenue, Madison, WI 53705, United States; Chippewa Valley Eye Clinic, 2715 Damon Street, Eau Claire, WI 54701, United States. Electronic address: ctdow@me.com.
authors.forename: Coad Thomas
authors.initials: CT
authors.lastname: Dow
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000382:microbiology; D001706:Biopsy; D002490:Central Nervous System / Q000473:pathology; D003424:Crohn Disease / Q000382:microbiology; D008040:Genetic Linkage; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007501:Iron / Q000737:chemistry; D016631:Lewy Bodies / Q000473:pathology; D016927:Mycobacterium avium subsp. paratuberculosis; D009615:Nocardia; D010283:Paratuberculosis / Q000382:microbiology; D010300:Parkinson Disease / Q000235:genetics / Q000382:microbiology* / Q000503:physiopathology; D012307:Risk Factors; D051843:Synucleins / Q000378:metabolism
chemical_list: D051843:Synucleins; D007501:Iron