title: Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study.
abstract: OBJECTIVE
  To determine whether baseline Heidelberg Retina Tomograph (HRT) measurements of the optic disc are associated with the development of open-angle glaucoma (OAG) in individuals with ocular hypertension in the European Glaucoma Prevention Study (EGPS).
  
  
  METHODS
  Retrospective analysis of a prospective, randomized, multicenter, double-masked, controlled clinical trial.
  
  
  METHODS
  There were 489 participants in the HRT Ancillary Study to the EGPS. Each baseline HRT parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of OAG. Proportional hazards models were used to identify HRT variables that predicted which participants in the EGPS had developed OAG. Development of OAG was based on visual field and/or optic disc changes.
  
  
  RESULTS
  At a median follow-up time of about 5 years, 61 participants developed OAG. In multivariate analyses, adjusting for randomization arm, age, baseline IOP, central corneal thickness, pattern standard deviation, and HRT disc area, the following HRT parameters were associated with the development of OAG: the "outside normal limits" classification of the Frederick Mikelberg (FSM) discriminant function (hazard ratio [HR] 2.51, 95% confidence interval [CI]: 1.45-4.35), larger mean cup depth (HR 1.64, 95% CI: 1.21-2.23), cup-to-disc area ratio (HR 1.43, 95% CI: 1.14-1.80), linear cup-to-disc ratio (HR 1.43, 95% CI: 1.13-1.80), cup area (HR 1.33, 95% CI: 1.08-1.64), smaller rim area (HR 1.33, 95% CI: 1.07-1.64), larger cup volume (HR 1.30, 95% CI: 1.05-1.61), smaller rim volume (HR 1.25, 95% CI: 1.01-1.54), larger maximum cup depth (HR 1.18, 95% CI: 1.01-1.36), and cup shape measure (HR 1.18, 95% CI: 1.01-1.36).
  
  
  CONCLUSIONS
  Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants.
authors.affiliation: Department of Ophthalmology, University of Milan Bicocca, Policlinico di Monza, Monza, Italy. Electronic address: stefano.miglior@unimib.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Miglior
authors.affiliation: Leuven University Hospitals, Leuven, Belgium.
authors.forename: Thierry
authors.initials: T
authors.lastname: Zeyen
authors.affiliation: Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
authors.forename: Esther M
authors.initials: EM
authors.lastname: Hoffmann
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Torri
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.
authors.forename: Eliana
authors.initials: E
authors.lastname: Rulli
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Floriani
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Poli
authors.affiliation: Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
authors.forename: Shakhsanam
authors.initials: S
authors.lastname: Aliyeva
authors.affiliation: Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Cunha-Vaz
authors.affiliation: Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Pfeiffer
mesh_terms: D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012189:Retrospective Studies; D014054:Tomography; D014794:Visual Fields