title: Family-based association study of the arsenite methyltransferase gene (AS3MT, rs11191454) in Korean children with attention-deficit hyperactivity disorder.
abstract: We examined the association between the selected polymorphisms in two candidate genes, the arsenite methyltransferase gene (AS3MT, rs11191454) and the inter-α-trypsin inhibitors heavy chain-3 gene (ITIH3, rs2535629), and attention-deficit hyperactivity disorder (ADHD) in a Korean population. A total of 238 patients with ADHD, along with both of their biological parents, were recruited. The children were administered intelligence quotient tests, whereas their parents completed the Child Behavior Checklist. In the transmission disequilibrium test on 181 trios, we found overtransmission of the A allele at the AS3MT rs11191454 polymorphism in children with ADHD (χ²=8.81, P=0.003). However, there was no preferential transmission at the ITIH3 rs52535629 polymorphism (χ²=0.14, P=0.707). Our results provide preliminary evidence for the overtransmission of the A allele at the AS3MT rs11191454 polymorphism in ADHD.
authors.affiliation: aDepartment of Psychiatry, Seoul National Hospital bDepartment of Psychiatry, Chung Ang University, College of Medicine cDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Seoul National University Hospital dUimyung Research Institute for Neuroscience, Sahmyook University, Seoul eDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Park
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Cheong
authors.forename: Doug Hyun
authors.initials: DH
authors.lastname: Han
authors.forename: Bung-Nyun
authors.initials: BN
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000510:Alpha-Globulins / Q000235:genetics; D020261:Arsenic Poisoning / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000523:psychology; D044466:Asian People / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007361:Intelligence Tests; D016014:Linear Models; D015810:Linkage Disequilibrium; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000510:Alpha-Globulins; C011877:inter-alpha-inhibitor; D008780:Methyltransferases; C505756:AS3MT protein, human