title: Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!
abstract: Sirtuin 7 is a member of the sirtuin family of proteins. Sirtuins were originally discovered in yeast for its role in prolonging replicative lifespan. Until recently SIRT7 happened to be the least studied sirtuin of the seven mammalian sirtuins. However, a number of recent breakthrough reports have provided significant clarity to SIRT7 biology. SIRT7 is now seen as a vital regulator of rRNA and protein synthesis for maintenance of normal cellular homeostasis. Proteins like p53, H3K18, PAF53, NPM1 and GABP-β1 are the known substrates for the deacetylase activity of SIRT7, thereby making it a key mediator of many cellular activities. Studies using in vitro based assays and also knockout mice have revealed a role of SIRT7 in certain disease pathologies as well. High expression of SIRT7 has been reported in few cancer types and is steadily propelling SIRT7 towards an oncogene status. The role of SIRT7 as a pro-survival adaptor molecule in conditions of cellular stress has recently emerged in view of the fact that SIRT7 can regulate molecules like HIF and IRE1α. Additionally, SIRT7 plays a key role in maintenance of the epigenome as it caused the deacetylation of histone (H3K18) and global proteomics studies have shown its interaction with many chromatin remodelling complexes such as B-WICH and other proteins. Lately, the role of SIRT7 in hepatic lipid metabolism has been debated. This review attempts to summarize these recent findings and present the role of SIRT7 as an important cellular regulator.
authors.affiliation: Laboratory of Cancer Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana 500001, India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Kiran
authors.affiliation: Laboratory of Cancer Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana 500001, India.
authors.forename: Tarique
authors.initials: T
authors.lastname: Anwar
authors.affiliation: Laboratory of Computational Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana 500001, India.
authors.forename: Manjari
authors.initials: M
authors.lastname: Kiran
authors.affiliation: Laboratory of Cancer Cell Biology, Department of Research, Institute of Liver and Biliary Sciences, Delhi 110070, India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Ramakrishna
mesh_terms: D000375:Aging; D000818:Animals; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D004275:DNA, Ribosomal / Q000378:metabolism; D004722:Endoribonucleases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D000090243:Nucleophosmin; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*
chemical_list: D004275:DNA, Ribosomal; D006657:Histones; C000715570:Npm1 protein, mouse; C539736:Sirt7 protein, mouse; D000090243:Nucleophosmin; D004722:Endoribonucleases; D037761:Sirtuins
keywords: Cancer; Hepatic lipid metabolism; SIRT7; Sirtuin; Stress