title: Haemophilus influenzae Genome Database (HIGDB): a single point web resource for Haemophilus influenzae.
abstract: BACKGROUND
  Haemophilus influenzae (H. Influenzae) is the causative agent of pneumonia, bacteraemia and meningitis. The organism is responsible for large number of deaths in both developed and developing countries. Even-though the first bacterial genome to be sequenced was that of H. Influenzae, there is no exclusive database dedicated for H. Influenzae. This prompted us to develop the Haemophilus influenzae Genome Database (HIGDB).
  
  
  METHODS
  All data of HIGDB are stored and managed in MySQL database. The HIGDB is hosted on Solaris server and developed using PERL modules. Ajax and JavaScript are used for the interface development.
  
  
  RESULTS
  The HIGDB contains detailed information on 42,741 proteins, 18,077 genes including 10 whole genome sequences and also 284 three dimensional structures of proteins of H. influenzae. In addition, the database provides "Motif search" and "GBrowse". The HIGDB is freely accessible through the URL: http://bioserver1.physics.iisc.ernet.in/HIGDB/.
  
  
  CONCLUSIONS
  The HIGDB will be a single point access for bacteriological, clinical, genomic and proteomic information of H. influenzae. The database can also be used to identify DNA motifs within H. influenzae genomes and to compare gene or protein sequences of a particular strain with other strains of H. influenzae.
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.
authors.forename: Rayapadi G
authors.initials: RG
authors.lastname: Swetha
authors.affiliation: Laboratory for Structural Biology and Bio-computing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Kala Sekar
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Ramaiah
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India. Electronic address: aanand@vit.ac.in.
authors.forename: Anand
authors.initials: A
authors.lastname: Anbarasu
authors.affiliation: Laboratory for Structural Biology and Bio-computing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Kanagaraj
authors.initials: K
authors.lastname: Sekar
mesh_terms: D030541:Databases, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D006193:Haemophilus influenzae / Q000235:genetics*; D020407:Internet; D008958:Models, Molecular; D012984:Software
keywords: Annotation; Database; Genome; Haemophilus influenzae; Resistance