title: Healthcare utilization and costs in women diagnosed with endometriosis before and after diagnosis: a longitudinal analysis of claims databases.
abstract: OBJECTIVE
  To assess healthcare resource utilization and costs during the 5 years before and 5 years after diagnosis among women with endometriosis, in comparison with women without endometriosis.
  
  
  METHODS
  Longitudinal, retrospective, case-control study.
  
  
  METHODS
  None.
  
  
  METHODS
  A total of 37,570 matched pairs of women with and without (controls) endometriosis were identified from the Truven Health MarketScan claims database (2000-2010).
  
  
  METHODS
  None.
  
  
  METHODS
  Annual healthcare resource utilization and costs (in 2010 US dollars) were evaluated for the 5 years before and 5 years after diagnosis.
  
  
  RESULTS
  Mean patient age at index (first diagnosis) date was 36.4 years for endometriosis patients and controls. Endometriosis patients had a higher utilization of outpatient and emergency room services during each pre- and postindex year, and a higher utilization of inpatient services during the last preindex year and all 5 postindex years. Total costs were highest in the first postindex year for endometriosis patients, reaching $13,199, compared with $3,747 for controls. Annual costs were significantly higher for patients than controls during each pre- and postindex year; overall, the cost difference was $26,305 over 10 years: $7,028 in the 5 years before diagnosis and $19,277 in the 5 years after diagnosis.
  
  
  CONCLUSIONS
  Endometriosis poses a significantly high economic burden, both before and after diagnosis. The highest resource utilization and costs experienced by endometriosis patients occur in the first year after diagnosis.
authors.affiliation: AbbVie, Inc., North Chicago, Illinois. Electronic address: Mahesh.fuldeore@abbvie.com.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Fuldeore
authors.affiliation: Analysis Group, Inc., Boston, Massachusetts.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yang
authors.affiliation: Analysis Group, Inc., Boston, Massachusetts.
authors.forename: Ella Xiaoyan
authors.initials: EX
authors.lastname: Du
authors.affiliation: AbbVie, Inc., North Chicago, Illinois.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Soliman
authors.affiliation: Analysis Group, Inc., Boston, Massachusetts.
authors.forename: Eric Q
authors.initials: EQ
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC.
authors.forename: Craig
authors.initials: C
authors.lastname: Winkel
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000553:Ambulatory Care / Q000191:economics* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D017281:Cost of Illness; D004636:Emergency Service, Hospital / Q000191:economics* / Q000706:statistics & numerical data; D004715:Endometriosis / Q000191:economics* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D007349:Insurance, Health, Reimbursement / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008875:Middle Aged; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D015995:Prevalence; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D014600:Utilization Review; D055815:Young Adult
keywords: Endometriosis; case–control; costs; economic burden; healthcare resource utilization