title: Sessile serrated adenoma: from identification to resection.
abstract: Until the past two decades, almost all colorectal polyps were divided into two main groups: hyperplastic polyps and adenomas. Sessile serrated adenomas presented endoscopic, pathological and molecular profiles distinct from others polyps. Previously under-diagnosed, physicians now identified sessile serrated adenomas. The serrated neoplastic pathway is accounting for up to one-third of all sporadic colorectal cancers and sessile serrated adenomas have been identified as the main precursor lesions in serrated carcinogenesis. By analogy with the adenoma-adenocarcinoma sequence, the sessile serrated adenomas-adenocarcinoma sequence, has been identified. The development of endoscopic resection techniques permits the consideration of a non-surgical approach as the first option regardless of the size of the lesion. Sessile serrated adenoma warrants the watchfulness of physicians and requires an optimal quality of the colonoscopy procedure, a thorough evaluation of the lesion, an adequate endoscopic resection and follow-up colonoscopies in accordance with sessile serrated adenomas guidelines. We herein present a review on sessile serrated adenomas focusing on their pathological specificities, epidemiology, treatment modalities and follow-up.
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Bordaçahar
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
authors.forename: Maximilien
authors.initials: M
authors.lastname: Barret
authors.affiliation: Paris Descartes University, Sorbonne Paris Cité, Paris, France; Department of Pathology, Cochin Teaching Hospital, AP-HP, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Terris
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Dhooge
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
authors.forename: Johann
authors.initials: J
authors.lastname: Dreanic
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Prat
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France. Electronic address: romain.coriat@cch.aphp.fr.
authors.forename: Romain
authors.initials: R
authors.lastname: Coriat
authors.affiliation: Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Chaussade
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000230:Adenocarcinoma / Q000235:genetics*; D000236:Adenoma / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D003111:Colonic Polyps / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D019175:DNA Methylation; D053843:DNA Mismatch Repair / Q000235:genetics; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D053842:Microsatellite Instability; D000070957:MutL Protein Homolog 1; D009687:Nuclear Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D048493:Proto-Oncogene Proteins B-raf; D000070957:MutL Protein Homolog 1
keywords: Colonoscopy; Colorectal cancer; Histology; Molecular pathology; Serrated adenoma