title: Virology and cell biology of the hepatitis C virus life cycle: an update.
abstract: Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways.
authors.affiliation: Institut Pasteur de Lille, Center for Infection & Immunity of Lille (CIIL), F-59019 Lille, France; CNRS UMR8204, F-59021 Lille, France; Inserm U1019, F-59019 Lille, France; Université Lille Nord de France, F-59000 Lille, France. Electronic address: jean.dubuisson@ibl.cnrs.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Dubuisson
authors.affiliation: CIRI - International Center for Infectiology Research, Team EVIR, Université de Lyon, Lyon, France; Inserm, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; CNRS, UMR5308, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; LabEx Ecofect, Université de Lyon, Lyon, France. Electronic address: flcosset@ens-lyon.fr.
authors.forename: François-Loïc
authors.initials: FL
authors.lastname: Cosset
mesh_terms: D003585:Cell Biology / Q000639:trends*; D016174:Hepacivirus / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity*; D006526:Hepatitis C / Q000473:pathology / Q000503:physiopathology; D022781:Hepatocytes / Q000473:pathology / Q000821:virology; D006801:Humans; D008018:Life Cycle Stages / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology; D012367:RNA, Viral / Q000502:physiology; D014773:Virology / Q000639:trends*; D014779:Virus Replication / Q000502:physiology
chemical_list: D012367:RNA, Viral
keywords: Hepatitis C virus; Viral life cycle; Virus entry; Virus-host interactions