title: MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches.
abstract: BACKGROUND
  To date, many publications have evaluated the correlation between the Ethylenetetrahydrofolate reductase gene (MTHFR) C677T and Ischemic Stroke susceptibility in adults. However, the results remain inconclusive. The meta-analysis was performed to resolve the problem.
  
  
  METHODS
  Based on 38 studies, dichotomous data were presented as the odds ratio (OR) with a 95% confidence interval (CI).
  
  
  RESULTS
  This study found, the carriers of the MTHFR 677C→T variation were more likely to increase the risk of Ischemic Stroke susceptibility in all over pooled population, including Asian and European, but not in African population (Europe: TT vs. CC+TC: OR = 1.364 95% CI = 1.010-1.841 p = 0.043; Asia subgroup: T vs. C: OR = 1.245, 95% CI = 1.141-1.358, p < 0.001; Africa: T vs. C: OR = 1.202, 95% CI = 0.990-1.459, p = 0.062). Among etiology stratified analysis, only large-artery atherosclerosis subgroups had a significant different, and the p value was less than 0.01 in all genetic models (T vs. C: OR = 1.29, 95% CI = 1.09-1.52, p = 0.002; TT+TC vs. CC: OR = 1.27, 95% CI = 1.06-1.51, p = 0.009; TT vs. CC+TC: OR = 1.62, 95% CI = 1.19-2.19, p = 0.002).
  
  
  CONCLUSIONS
  This meta-analysis suggests that MTHFR C677T mutation increased the risk of Ischemic Stroke in adults, especially in large-artery atherosclerosis.
authors.affiliation: a Department of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology, HeNan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Cui
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000208:ethnology / Q000235:genetics*; D044383:Black People / Q000235:genetics; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics*; D016001:Confidence Intervals; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: MTHFR gene; gene polymorphism; ischemic stroke; meta-analysis; susceptibility