title: Serum sCD26 for colorectal cancer screening in family-risk individuals: comparison with faecal immunochemical test.
abstract: BACKGROUND
  The development of specific screening programs for individuals with a family history of colorectal cancer (CRC) is a priority. This study evaluates the diagnostic performance of serum soluble CD26 (sCD26) in family-risk individuals and compares this marker with the faecal immunochemical test for the detection of advanced neoplasia (AN) (CRC or advanced adenomas; AA).
  
  
  METHODS
  Five hundred and sixteen asymptomatic individuals with at least one first-degree relative with CRC were included. Serum sCD26 was measured in all the individuals who also underwent a colonoscopy (53 AA and four cancer cases were found) and a faecal immunochemical test.
  
  
  RESULTS
  Setting specificity to 90% and 95%, respectively, sCD26 showed a sensitivity of 39.6% and 28.3% for AA, and of 42.1% and 28.1% for AN. The combination of sCD26 and the faecal test detected AA and AN with a 52.8% and 56.1% sensitivity, corresponding to 93.5% specificity.
  
  
  CONCLUSIONS
  The combination of serum sCD26 and the faecal blood test could result a valuable strategy for detecting AN in familial-risk CRC screening.
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Universidad de Vigo, 36310 Vigo, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Otero-Estévez
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Universidad de Vigo, 36310 Vigo, Spain.
authors.forename: L
authors.initials: L
authors.lastname: De Chiara
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Universidad de Vigo, 36310 Vigo, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Rodríguez-Berrocal
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Universidad de Vigo, 36310 Vigo, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Páez de la Cadena
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, 32005 Ourense, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cubiella
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, 32005 Ourense, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Castro
authors.affiliation: Department of Clinical Analysis, Complexo Hospitalario Universitario de Vigo, 36200 Vigo, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Gonzalez-Mao
authors.affiliation: Department of Gastroenterology, Complexo Hospitalario Universitario de Vigo, 36200 Vigo, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Hernandez
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Universidad de Vigo, 36310 Vigo, Spain.
authors.forename: V S
authors.initials: VS
authors.lastname: Martínez-Zorzano
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D004311:Double-Blind Method; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D011446:Prospective Studies; D012306:Risk; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4