title: The mitochondrial permeability transition pore and its adaptive responses in tumor cells.
abstract: This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) - a key effector in the mitochondrial pathways to cell death - and on the adaptive responses of tumor cells that desensitize the PTP to Ca(2+) and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F-ATP synthase; and the definition of the Ca(2+)- and ROS-dependent signaling pathways affecting the transition of the F-ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells.
authors.affiliation: Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address: rasola@bio.unipd.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Rasola
authors.affiliation: Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address: bernardi@bio.unipd.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernardi
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology*; D000083162:Mitochondrial Permeability Transition Pore; D025261:Mitochondrial Proton-Translocating ATPases / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species; D025261:Mitochondrial Proton-Translocating ATPases; D002118:Calcium
keywords: Cancer; F-ATP synthase; Mitochondria; Permeability transition; Reactive oxygen species