title: Chronic kidney disease, frailty, and unsuccessful aging: a review.
abstract: The global prevalence of chronic kidney disease (CKD) is rising, particularly among the elderly population. Defining aging as successful or unsuccessful has become clinically relevant in the last 15 years, with an increased recognition of the frail phenotype. Frailty has been shown to be associated with CKD and poorer outcomes, such as death or dialysis. It is likely that the mechanisms of disease in CKD such as altered protein metabolism, inflammation, oxidative stress, and anemia accelerate normal aging and lead to worsening frailty in elderly patients with CKD.
authors.affiliation: Department of Medicine, Division of Nephrology, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Simon R
authors.initials: SR
authors.lastname: Walker
authors.affiliation: Department of Medicine, Division of Nephrology, University of Würzburg, Bavaria, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Department of Medicine, Division of Nephrology, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: ntangri@sogh.mb.ca.
authors.forename: Navdeep
authors.initials: N
authors.lastname: Tangri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000740:Anemia / Q000097:blood / Q000453:epidemiology*; D002118:Calcium / Q000097:blood; D016330:Frail Elderly; D006801:Humans; D044342:Malnutrition / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000453:epidemiology*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D014807:Vitamin D; D002118:Calcium