title: Caveolae, lipid droplets, and adipose tissue biology: pathophysiological aspects.
abstract: Adipocytes are specialized cells that function to store energy in the form of lipids, predominantly triglycerides (TGs), and as a regulatory system contributing to metabolic homoeostasis through the production and secretion of hormones and cytokines. The regulation of lipid homeostasis by adipose tissue is an important aspect of whole-body metabolism. Owing to the central nature of adipose tissue in lipid metabolism, dysregulation has wide-ranging effects, contributing to disorders as diverse as diabetes, cardiovascular disease, cancer, and neurodegeneration. Excess lipids are stored in specialized organelles called lipid droplets (LDs). The surface of the lipid droplet can be considered a highly regulated membrane domain that both protects the contents of the LD from unregulated lipolysis and the cell from the cytotoxic effects of elevated free fatty acids. The surface of the LD is coated with a variety of regulatory proteins, either resident or transiently associated, including enzymes involved in the breakdown of TG, lipid transport proteins, and cofactors. Recent studies have begun to unravel the range of LD-associated proteins and to define their functional significance. Importantly, the involvement of LD proteins in pathophysiological disorders is beginning to be understood. This review will outline recent advances in defining the diversity of LD-associated proteins and their links to metabolic disorders including the integral membrane protein, caveolin-1 (CAV1). Analysis of the role of CAV1 in adipose tissue has highlighted the interconnectedness between the regulation of lipid storage and the function of the adipocyte plasma membrane.
authors.affiliation: Queensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia.  s.martin@uq.edu.au
authors.forename: Sally
authors.initials: S
authors.lastname: Martin
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D021941:Caveolae / Q000378:metabolism / Q000473:pathology*; D051242:Caveolin 1 / Q000032:analysis / Q000378:metabolism; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism / Q000473:pathology*; D008066:Lipolysis
chemical_list: D051242:Caveolin 1