title: ER stress: how trypanosomes deal with it.
abstract: An efficient response to endoplasmic reticulum (ER) stress is essential for the viability of eukaryotic cells. The causative agent of African sleeping sickness, Trypanosoma brucei, responds to such stress by inducing spliced leader RNA silencing (SLS), resulting in shutdown of mRNA biogenesis. A new study elucidates the activation cascade and its molecular components, which are unique to the ER stress response in trypanosomes.
authors.affiliation: Institute of Biochemistry, Justus Liebig University of Giessen, D-35392 Giessen, Germany. Electronic address: albrecht.bindereif@chemie.bio.uni-giessen.de.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Bindereif
authors.affiliation: Institute of Biochemistry, Justus Liebig University of Giessen, D-35392 Giessen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Preußer
mesh_terms: D000818:Animals; D017209:Apoptosis; D059865:Endoplasmic Reticulum Stress / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006790:Host-Parasite Interactions; D006801:Humans; D034622:RNA Interference; D020038:RNA, Spliced Leader / Q000235:genetics; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000502:physiology*
chemical_list: D020038:RNA, Spliced Leader
keywords: SL RNA silencing; Trypanosoma; programmed cell death; unfolded protein response