title: Gastric acid secretion: changes during a century.
abstract: The advances in knowledge of gastric physiology within the past century have been the most exciting and important in this area of interest for many decades. The aim of this presentation consists of a comprehensive review of the extensive recent literature on this topic in order to highlight milestones in the field of gastric physiology, in particular in gastric acid secretion, gastric pathophysiology, acid-related diseases and use of acid regulatory drugs. Moreover, in the 21st century there have been many epidemiologic changes as well as a decrease of Helicobacter pylori infection and gastric cancer together with an increase of gastroesophageal reflux disease and the related increase of pomp proton inhibitor wide use.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Parma, School of Medicine, Via Gramsci 14, 43125, Parma, Italy. Electronic address: francesco.dimario@unipr.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Mario
authors.affiliation: Department of Clinical and Experimental Medicine, University of Parma, School of Medicine, Via Gramsci 14, 43125, Parma, Italy. Electronic address: elisabetta.goni@gmail.com.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Goni
mesh_terms: D005744:Gastric Acid / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000378:metabolism* / Q000382:microbiology; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D013270:Stomach / Q000502:physiology*
keywords: Acid regulatory drugs; Chronic atrophic gastritis; Dyspepsia; GERD; Gastric acid secretion; Gastric cancer risk; Gastric physiology; Helicobacter pylori infection; Peptic ulcer disease