title: Beyond autonomic neuromodulation: acetylcholinesterase inhibitor against peripheral artery disease.
abstract: The acetylcholinesterase inhibitor (AChEI)-based therapeutic strategies have been shown to have vasculoprotective properties in the animal model of hindlimb ischemia due to its activation of the endothelial cholinergic system. However, little is know about whether other cell types (myocytes, immunocytes) are involved in the AChEI-related therapeutic benefits in peripheral artery disease. Therefore, we review the multiple cell-targeted effects of AChEI on the animal model of hindlimb ischemia and explore its clinical application in angiomyogenesis.
authors.affiliation: Department of Vascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: gilberthaocn@163.com.
authors.forename: Chang-Ning
authors.initials: CN
authors.lastname: Hao
authors.affiliation: Department of Vascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yi-Qin
authors.initials: YQ
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Ze-En
authors.initials: ZE
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Cardiology, Yanbian University School of Medicine, Yanji, China. Electronic address: xianwu@med.nagoya-u.ac.jp.
authors.forename: Xianwu
authors.initials: X
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology
chemical_list: D002800:Cholinesterase Inhibitors
keywords: Acetylcholinesterase inhibitor; Angiomyogenesis; Peripheral artery disease