title: Innate immunity and epigenetic plasticity in cellular reprogramming.
abstract: Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.
authors.affiliation: Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States. Electronic address: jpcooke@houstonmethodist.org.
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
authors.affiliation: Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States.
authors.forename: Nazish
authors.initials: N
authors.lastname: Sayed
authors.affiliation: Department of Medicine, Stanford University, United States.
authors.forename: Jieun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States.
authors.forename: Wing Tak
authors.initials: WT
authors.lastname: Wong
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming / Q000276:immunology*; D044127:Epigenesis, Genetic; D006801:Humans; D007113:Immunity, Innate; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism