title: The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps.
abstract: BACKGROUND
  Genetic variability in DNA repair genes may contribute to differences in DNA repair capacity and susceptibility to colon polyps and cancer. In this study, we examined the role of MGMT polymorphisms in colon polyps formation.
  
  
  METHODS
  PCR-SSCP analysis was performed included 254 patients with colon polyps and 330 controls.
  
  
  RESULTS
  The homozygous F84F genotype was significantly more prevalent in study group than in controls. The polymorphic allele 84F was more frequent appeared in group of older patients and in group of smoking patients. On the other hand, there were no association between 84F and gender, size of polyps, cancer family history.
  
  
  CONCLUSIONS
  We concluded that high frequency of 84F allele in the group of patients may suggest the role of the MGMT variant in colon polyps etiology.
authors.affiliation: Department of Oncological Surgery II, Greater Poland Cancer Centre, Poznań, Poland. Electronic address: witold.kycler@wco.pl.
authors.forename: Witold
authors.initials: W
authors.lastname: Kycler
authors.affiliation: Department of Pathology, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Konstanty
authors.initials: K
authors.lastname: Korski
authors.affiliation: Department of Oncological Surgery II, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Loziński
authors.affiliation: Cancer Genetics Laboratory, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Teresiak-Mańczak
authors.affiliation: University of Medical Sciences, Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Przybyła
authors.affiliation: University of Medical Sciences, Poznań, Poland; Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mackiewicz
authors.affiliation: Microbiology Laboratory, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Zefiryn
authors.initials: Z
authors.lastname: Cybulski
authors.affiliation: Cancer Genetics Laboratory, Greater Poland Cancer Centre, Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lamperska
mesh_terms: D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D003106:Colon / Q000473:pathology*; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011127:Polyps / Q000235:genetics* / Q000473:pathology; D012907:Smoking / Q000453:epidemiology
chemical_list: D019853:O(6)-Methylguanine-DNA Methyltransferase
keywords: Colon cancer; Colon polyps; Genetic analysis; MGMT