title: Effect of gefitinib plus Chinese herbal medicine (CHM) in patients with advanced non-small-cell lung cancer: a retrospective case-control study.
abstract: BACKGROUND
  Some patients with non-small-cell lung cancer (NSCLC) respond well to the EGFR tyrosine kinase inhibitor gefitinib. Chinese herbal medicine (CHM) was effective in improving the quality of life and prolonging overall survival in patient with NSCLC. We aim to determine whether gefitinib plus CHM could prolong the progression-free survival (PFS) or median survival time (MST) in patients with NSCLC than gefitinib alone.
  
  
  METHODS
  We retrospectively analyzed 159 non-small-cell lung cancer patients with the method of retrospective case-control study, matching factors included gender, age categories (30-39,40-49,50-59,60-69,70-79), pathological stage (IIIB or IV), smoking status (never: <100 lifetime cigarettes, or ever: ≥100 lifetime cigarettes), pathology, and performance status. Among the 159 patients, 100 patients treated with gefitinib (250mg/day orally) plus CHM ("Fuzheng Kang'ai" decoction, a Chinese herbal medicine, 250ml/bid/day orally), 59 patients treated with gefitinib (250mg/day orally) only. PFS and MST were analyzed for the whole population.
  
  
  RESULTS
  58 pairs were matched successfully. 1 patient (treated with gefitinib) with the age of 27 years failed to be matched. Progression-free survival was significantly longer in patients treated with gefitinib plus CHM than with gefitinib: median PFS was 13.1 months (95% CI 6.50-19.70) with gefitinib plus CHM versus 11.43 months (95% CI 7.95-14.91) with gefitinib (log-rank P=0.013). Median overall survival was longer with gefitinib plus CHM than with gefitinib: median MST was 22.83 months (95% CI 17.51-28.16) with gefitinib plus CHM versus 18.7 months (95% CI 16.83-20.57) with gefitinib (log-rank P=0.049). The most common adverse event was rash, the incidence in the gefitinib plus CHM group was 41.38% while in the gefitinib group was 24.14% (P=0.048).
  
  
  CONCLUSIONS
  This case-control analysis suggested that treatment with gefitinib plus CHM prolonged PFS and MST compared with gefitinib in patients with NSCLC, and it is worthy of further study.
authors.affiliation: Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 36, Huadi Yong'An Street, Liwan District, Guangzhou 510120, China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Yang
authors.affiliation: Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 36, Huadi Yong'An Street, Liwan District, Guangzhou 510120, China. Electronic address: wwanyin@126.com.
authors.forename: Wan-Yin
authors.initials: WY
authors.lastname: Wu
authors.affiliation: Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 36, Huadi Yong'An Street, Liwan District, Guangzhou 510120, China.
authors.forename: Shun-Qin
authors.initials: SQ
authors.lastname: Long
authors.affiliation: Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 36, Huadi Yong'An Street, Liwan District, Guangzhou 510120, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 36, Huadi Yong'An Street, Liwan District, Guangzhou 510120, China.
authors.forename: Zong-Qi
authors.initials: ZQ
authors.lastname: Pan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D016022:Case-Control Studies; D018572:Disease-Free Survival; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D005260:Female; D000077156:Gefitinib; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011799:Quinazolines / Q000008:administration & dosage; D012189:Retrospective Studies
chemical_list: D004365:Drugs, Chinese Herbal; D011799:Quinazolines; D000077156:Gefitinib
keywords: Case–control analysis; Chinese herbal medicine; Gefitinib; Non-small-cell lung cancer