title: The role of Mycoplasma and Ureaplasma in adverse pregnancy outcomes.
abstract: Genital mycoplasmas are frequently found in the vaginal flora across socioeconomic and ethnic groups and have been demonstrated to be involved in adverse perinatal outcomes. Both Mycoplasma and Ureaplasma spp cause inflammation potentially leading to spontaneous preterm birth and PPROM as well as postdelivery infectious complications and neonatal infections. Herein we have provided an overview of the existing literature and supportive evidence for genital mycoplasma's role in perinatal complications. Future research will need to focus on clearly delineating the species, allowing for discrimination of their effects.
authors.affiliation: Department of Obstetrics and Gynecology, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA; Division of Maternal Fetal Medicine, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA; Department of Pediatrics, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA. Electronic address: amy.murtha@dm.duke.edu.
authors.forename: Amy P
authors.initials: AP
authors.lastname: Murtha
authors.affiliation: Department of Obstetrics and Gynecology, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Edwards
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D002821:Chorioamnionitis / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000382:microbiology; D009174:Mycoplasma / Q000302:isolation & purification*; D009175:Mycoplasma Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000382:microbiology / Q000517:prevention & control*; D015995:Prevalence; D014509:Ureaplasma / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D014621:Vagina / Q000382:microbiology
chemical_list: D000998:Antiviral Agents
keywords: Bronchopulmonary dysplasia; Chorioamnionitis; Endometritis; Genital mycoplasma; Mycoplasma; Preterm birth; Ureaplasma