title: The effect of adding zinc to vitamin A on IGF-1, bone age and linear growth in stunted children.
abstract: A randomized, double-blind, placebo controlled trial of a single dose of 200,000 I.U. of vitamin A with daily zinc supplementation was conducted with children in Mojo village, Surabaya City. Children aged 48 to 60 months were randomized to receive a single dose of 200,000 I.U. of vitamin A plus zinc sulfate (n=12) or a single dose of 200,000 I.U. of vitamin A (n=12) plus placebo six days a week for six months. Children were evaluated weekly for nutrient intake and for IGF-1, C-reactive protein levels, gamma globulin levels, serum zinc, serum retinol, bone age and the index height for age at six months. At the end of the study, there was a significant increase in the serum retinol level (p<0.03), serum zinc level (p<0.03), IGF-1 hormone (p<0.04) and Z-score height for age (p<0.001), bone age (p<0.01), and gamma globulin level (p<0.04) and a significant decrease in the amount of infection/inflammation measured by CRP level (p<0.001). There was also a significant correlation between CRP level and height for age (p<0.01), and between gamma level and height for age (p<0.01). These results suggest that combined vitamin A and zinc supplementation reduces the risk of infection and increases linear growth among children, and thus may play a key role in controlling infection and stunted growth for children under five years old.
authors.affiliation: Department of Nutrition School of Public Health, Airlangga University, Surabaya 60115, Indonesia. Electronic address: anna_b_wirjatmadi@yahoo.com.
authors.forename: Merryana
authors.initials: M
authors.lastname: Adriani
authors.affiliation: Department of Nutrition School of Public Health, Airlangga University, Surabaya 60115, Indonesia.
authors.forename: Bambang
authors.initials: B
authors.lastname: Wirjatmadi
mesh_terms: D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D014801:Vitamin A / Q000097:blood / Q000494:pharmacology*; D015032:Zinc / Q000097:blood; D019287:Zinc Sulfate / Q000494:pharmacology*; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D005719:gamma-Globulins; D014801:Vitamin A; D007334:Insulin-Like Growth Factor I; D019287:Zinc Sulfate; D002097:C-Reactive Protein; D015032:Zinc
keywords: Bone age and linear growth (H/A); Gamma globulin; IGF-1; Stunting; Zinc and vitamin A supplementation on CRP