title: Chemical imaging and solid state analysis at compact surfaces using UV imaging.
abstract: Fast non-destructive multi-wavelength UV imaging together with multivariate image analysis was utilized to visualize distribution of chemical components and their solid state form at compact surfaces. Amorphous and crystalline solid forms of the antidiabetic compound glibenclamide, and microcrystalline cellulose together with magnesium stearate as excipients were used as model materials in the compacts. The UV imaging based drug and excipient distribution was in good agreement with hyperspectral NIR imaging. The UV wavelength region can be utilized in distinguishing between glibenclamide and excipients in a non-invasive way, as well as mapping the glibenclamide solid state form. An exploratory data analysis supported the critical evaluation of the mapping results and the selection of model parameters for the chemical mapping. The present study demonstrated that the multi-wavelength UV imaging is a fast process analytical technique with the potential for real-time monitoring of critical quality attributes.
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark.
authors.forename: Jian X
authors.initials: JX
authors.lastname: Wu
authors.affiliation: University of Hamburg, Department of Chemistry, Division of Pharmaceutical Technology, Bundesstrasse 45, 20146 Hamburg, Germany.
authors.forename: Sönke
authors.initials: S
authors.lastname: Rehder
authors.affiliation: Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg, Denmark.
authors.forename: Frans van den
authors.initials: Fv
authors.lastname: Berg
authors.affiliation: Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg, Denmark.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Amigo
authors.affiliation: DTU Compute, Technical University of Denmark, Building 321, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Jens Michael
authors.initials: JM
authors.lastname: Carstensen
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rades
authors.affiliation: University of Hamburg, Department of Chemistry, Division of Pharmaceutical Technology, Bundesstrasse 45, 20146 Hamburg, Germany.
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Leopold
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark. Electronic address: jukka.rantanen@sund.ku.dk.
authors.forename: Jukka
authors.initials: J
authors.lastname: Rantanen
mesh_terms: D002482:Cellulose / Q000737:chemistry; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D005905:Glyburide / Q000008:administration & dosage / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry*; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D015999:Multivariate Analysis; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D044367:Phase Transition; D025341:Principal Component Analysis; D013229:Stearic Acids / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014466:Ultraviolet Rays
chemical_list: D004337:Drug Carriers; D005079:Excipients; D007004:Hypoglycemic Agents; D004364:Pharmaceutical Preparations; D013229:Stearic Acids; C031183:stearic acid; D002482:Cellulose; C109691:microcrystalline cellulose; D005905:Glyburide
keywords: Glibenclamide; Multivariate curve resolution; Multivariate image analysis; NIR imaging; Solid state packing; UV imaging