title: Prevalence and characteristics of Streptococcus pneumoniae "putative serotype 6E" isolates from Asian countries.
abstract: The prevalence, antimicrobial susceptibility, and genotypes of Streptococcus pneumoniae “putative serotype 6E” isolates from Asian countries were investigated. A total of 244 S. pneumoniae serogroup 6 isolates obtained from 11 Asian countries were included in this study. Of the 244 serogroup 6 isolates, 101 (41.4%) were typed as "putative serotype 6E," followed by serotypes 6A, 6B, 6C, and 6D (27.0, 20.1, 5.7, and 5.7%, respectively). Multilocus sequence typing revealed that clonal complex (CC) 90, including ST90 and its variants, was the most prevalent clonal group of "putative serotype 6E" isolates (n = 63; 62.4%). CC146 and CC315 were also found frequently in some of the countries. Most of the "putative serotype 6E" isolates showed very high resistance rates against cefuroxime, erythromycin, azithromycin, clarithromycin, clindamycin, and trimethoprim/sulfamethoxazole, probably due to their highly resistant to antimicrobials clone, CC90. Our results indicate that “putative serotype 6E” is prevalent in Asian countries. The clonal dissemination of "putative serotype 6E" isolates was also identified.
authors.forename: Jin Yang
authors.initials: JY
authors.lastname: Baek
authors.forename: In Ho
authors.initials: IH
authors.lastname: Park
authors.forename: Thomas Man-kit
authors.initials: TM
authors.lastname: So
authors.forename: M K
authors.initials: MK
authors.lastname: Lalitha
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shimono
authors.forename: Rohani Md
authors.initials: RM
authors.lastname: Yasin
authors.forename: Celia C
authors.initials: CC
authors.lastname: Carlos
authors.forename: Jennifer
authors.initials: J
authors.lastname: Perera
authors.forename: Visanu
authors.initials: V
authors.lastname: Thamlikitkul
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
authors.forename: Pham Hung
authors.initials: PH
authors.lastname: Van
authors.forename: Atef M
authors.initials: AM
authors.lastname: Shibl
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001208:Asia; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents