title: Preventive treatments for breast cancer: recent developments.
abstract: Breast cancer is a burden for western societies, and an increasing one in emerging economies, because of its high incidence and enormous psychological, social, sanitary and economic costs. However, breast cancer is a preventable disease in a significant proportion. Recent developments in the armamentarium of effective drugs for breast cancer prevention (namely exemestane and anastrozole), the new recommendation from the National Institute for Health and Care Excellence to use preventative drugs in women at high risk as well as updated Guidelines from the US Preventive Services Task Force and the American Society of Clinical Oncology should give renewed momentum to the pharmacological prevention of breast cancer. In this article we review recent major developments in the field and examine their ongoing repercussion for breast cancer prevention. As a practical example, the potential impact of preventive measures in Spain is evaluated and a course of practical actions is delineated.
authors.affiliation: Hospital Nuestra Señora de Sonsoles, GEICAM Spanish Breast Cancer Group, Ávila, Spain, jealesm@seom.org.
authors.forename: J E
authors.initials: JE
authors.lastname: Alés-Martínez
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: J I
authors.initials: JI
authors.lastname: Chacón
authors.forename: A
authors.initials: A
authors.lastname: Lluch Hernández
authors.forename: M
authors.initials: M
authors.lastname: Ramos
authors.forename: O
authors.initials: O
authors.lastname: Córdoba
authors.forename: E
authors.initials: E
authors.lastname: Aguirre
authors.forename: A
authors.initials: A
authors.lastname: Barnadas
authors.forename: C
authors.initials: C
authors.lastname: Jara
authors.forename: S
authors.initials: S
authors.lastname: González
authors.forename: A
authors.initials: A
authors.lastname: Plazaola
authors.forename: J
authors.initials: J
authors.lastname: Florián
authors.forename: R
authors.initials: R
authors.lastname: Andrés
authors.forename: P
authors.initials: P
authors.lastname: Sánchez Rovira
authors.forename: A
authors.initials: A
authors.lastname: Frau
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D013629:Tamoxifen