title: Ca(2+)- and CaMKII-mediated processes in early LTP.
abstract: Learning methods determine the degree of stimulation of engrams encoding information to be memorised. More enriching modes of learning allow more enduring long-term potentiation of the synapses associated with these memories. The additional activity causes a prolonged increase in [Ca2+] in the dendritic spine of the postsynaptic neuron. This allows Ca(2+)-mediated molecular pathways to bring about cytoskeletal remodeling, posttranslational modifications, and protein trafficking. These processes contribute to early long-term potentiation of the synapses, strengthening the memory they store and lead to improved performance on tests of memory recall.
authors.affiliation: School of Natural Sciences, Nathan Campus, Griffith University 170 Kessels Rd, Nathan Brisbane, QLD, 4111, AUSTRALIA.
authors.forename: Lachlan A
authors.initials: LA
authors.lastname: Byth
keywords: AMPARs; Calcium signalling; Calcium/calmodulin-dependent protein kinase II; Long-term potentiation; Signal transduction