title: Predicting Cognitive, Functional, and Diagnostic Change over 4 Years Using Baseline Subjective Cognitive Complaints in the Sydney Memory and Ageing Study.
abstract: OBJECTIVE
  There is limited understanding of the usefulness of subjective cognitive complaint(s) (SCC) in predicting longitudinal outcome because most studies focus solely on memory (as opposed to nonmemory cognitive) complaints, do not collect data from both participants and informants, do not control for relevant covariates, and have limited outcome measures. Therefore the authors investigate the usefulness of participant and informant SCCs in predicting change in cognition, functional abilities, and diagnostic classification of mild cognitive impairment or dementia in a community-dwelling sample over 4 years.
  
  
  METHODS
  Nondemented participants (N = 620) in the Sydney Memory and Ageing Study aged between 70 and 90 years completed 15 memory and 9 nonmemory SCC questions. An informant completed a baseline questionnaire that included 15 memory and 4 nonmemory SCC questions relating to the participant. Neuropsychological, functional, and diagnostic assessments were carried out at baseline and again at 4-year follow-up. Cross-sectional and longitudinal analyses were carried out to determine the association between SCC indices and neuropsychological, functional, and diagnostic data while controlling for psychological measures.
  
  
  RESULTS
  Once participant characteristics were controlled for, participant complaints were generally not predictive of cognitive or functional decline, although participant memory-specific complaints were predictive of diagnostic conversion. Informant-related memory questions were associated with global cognitive and functional decline and with diagnostic conversion over 4 years.
  
  
  CONCLUSIONS
  Informant memory complaint questions were better than participant complaints in predicting cognitive and functional decline as well as diagnoses over 4 years.
authors.affiliation: Dementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Slavin
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Kochan
authors.affiliation: Dementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Woolf
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Crawford
authors.affiliation: Dementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: Katrina
authors.initials: K
authors.lastname: Giskes
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: Simone
authors.initials: S
authors.lastname: Reppermund
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia.
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.affiliation: Dementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Draper
authors.affiliation: Falls and Balance Research Group, Neuroscience Research Australia, Randwick, New South Wales, Australia.
authors.forename: Kim
authors.initials: K
authors.lastname: Delbaere
authors.affiliation: Dementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, The University of New South Wales, New South Wales, Australia; Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, New South Wales, Australia. Electronic address: h.brodaty@unsw.edu.au.
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D011379:Prognosis
keywords: Complaints; cognition; dementia; mild cognitive impairment