title: Alterations in the basal ganglia in patients with brain tumours may be due to excessive iron deposition.
abstract: The accumulation of iron in the brain is a common physiological process. However, alterations in the deposition of iron or other paramagnetic substances are associated with various diseases. In the present study, the deposition of paramagnetic substances in patients with brain tumours was evaluated using T2relaxometry. A total of 23 patients with untreated tumours or with recurrent tumours following treatment, together with a group of 19 age-matched healthy controls, were examined using T2relaxometry at 3T. The relaxation times in the basal ganglia, thalamus and white matter were evaluated. Significantly lower T2relaxation times were identified in the basal ganglia and thalamus of the patients with tumours, as compared with those of the controls (P<0.05). No statistically significant difference was identified between patients with untreated or recurrent brain tumours. The reduction in T2relaxation times in the brain tumour patients was possibly caused by the accumulation of iron, since iron homeostasis is known to be altered in patients with tumours. We propose that increased iron deposition is a consequence of a higher risk of oxidative stress caused by an increased iron concentration in the plasma or cerebrospinal fluid.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Vídeňská, Prague 14021, Czech Republic.
authors.forename: Vít
authors.initials: V
authors.lastname: Herynek
authors.affiliation: Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Vídeňská, Prague 14021, Czech Republic.
authors.forename: Dita
authors.initials: D
authors.lastname: Wagnerová
authors.affiliation: Department of Neurosurgery, JE Purkyně University and Masaryk Hospital, Sociální péče, Ústí nad Labem 40113, Czech Republic.
authors.forename: Alberto
authors.initials: A
authors.lastname: Malucelli
authors.affiliation: Department of Radiology, Na Homolce Hospital, Roentgenova, Prague 15030, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Vymazal
authors.affiliation: Department of Neurosurgery, JE Purkyně University and Masaryk Hospital, Sociální péče, Ústí nad Labem 40113, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Sameš
authors.affiliation: Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Vídeňská, Prague 14021, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Hájek
keywords: basal ganglia; brain tumours; iron; magnetic resonance imaging; oxidative stress