title: Quantitative bone ultrasound at the distal radius in adults with cystic fibrosis.
abstract: It is of clinical importance to identify bone disease related to cystic fibrosis (CF) early in its course to allow therapeutic interventions that optimize bone health. To test the technical (precision) and clinical (percentage of abnormal results, correlation with clinical parameters) performance of a commercial quantitative ultrasound apparatus for radial measurements, speed of sound (SOS) was measured at the distal third of the left radius with the Omnisense 7000p apparatus (Sunlight Medical, Tel-Aviv, Israel) in a group of young adult CF patients with regular follow-up at the Brussels and Ghent University Hospital. Sixty-three (37 males) CF patients at a median (range) age of 23.5 y (18.1-39.9) were included. SOS, SOS z-score and SOS t-score were respectively 4017 ± 97 m/s, -0.31 ± 0.74 and -0.60 ± 0.78 in males and 4086 ± 97 m/s, -0.19 ± 0.75 and -0.51 ± 0.95 in females. Mean SOS t-score was significantly lower compared with the manufacturer's reference data for males (p < 0.0001) and females (p = 0.01). SOS z- and t-scores correlated with weight z-score and body mass index z-score in females. No significant correlation was found between SOS and forced expiratory volume in 1 s (%). Neither diabetes mellitus nor liver disease was found to influence SOS. Radial quantitative ultrasound has a precision of 0.55%. The SOS is in the low normal range in 14% of CF patients and is influenced by weight in female patients, but not by the severity of the lung disease.
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium. Electronic address: inge.roggen@uzbrussel.be.
authors.forename: Inge
authors.initials: I
authors.lastname: Roggen
authors.affiliation: Department of Radiology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Olivia
authors.initials: O
authors.lastname: Louis
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Gent, Ghent, Belgium.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Van Biervliet
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Gent, Ghent, Belgium.
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Daele
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Gent, Ghent, Belgium.
authors.forename: Eddy
authors.initials: E
authors.lastname: Robberecht
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Elke
authors.initials: E
authors.lastname: De Wachter
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Malfroot
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Gent, Ghent, Belgium.
authors.forename: Kathleen
authors.initials: K
authors.lastname: De Waele
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Inge
authors.initials: I
authors.lastname: Gies
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Jesse
authors.initials: J
authors.lastname: Vanbesien
authors.affiliation: Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Jette, Belgium.
authors.forename: Jean
authors.initials: J
authors.lastname: De Schepper
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D011884:Radius / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods*; D014955:Wrist Joint / Q000000981:diagnostic imaging; D055815:Young Adult
keywords: Bone mineral density; Cystic fibrosis; Malnutrition; Osteoporosis; Quantitative ultrasound