title: Synthesis and evaluation of curcumin-related compounds containing inden-2-one for their effects on human cancer cells.
abstract: Indanones are very useful molecules as starting building blocks for the synthesis of biologically active compounds. A series of novel curcumin-related compounds containing indan-2-one were synthesized and screened for anticancer activities. The structures were confirmed by spectral data (IR, NMR, and Mass). Inhibitory effects of these compounds on the growth of prostate cancer PC-3 cells, pancreatic cancer BxPC-3 cells, colon cancer HT-29 cells, lung cancer H1299 cells and non-tumorigenic human prostate epithelial RWPE-1 cells were determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The IC50 for compound IND-4 was lower than 1 µM in the four cancer cell lines. The present study indicates that IND-4 may have useful effects on human cancer cells.
authors.affiliation: Guangdong Food and Drug Vocational College.
authors.forename: Daiying
authors.initials: D
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Suqing
authors.initials: S
authors.lastname: Zhao
authors.forename: Dongli
authors.initials: D
authors.lastname: Li
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Van Doren
authors.forename: Yu
authors.initials: Y
authors.lastname: Qian
authors.forename: Xingchuan
authors.initials: X
authors.lastname: Wei
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003474:Curcumin