title: Bone marrow transplantation for acquired severe aplastic anemia.
abstract: This article addresses current transplant options for patients with acquired severe aplastic anemia (SAA). This discussion includes ongoing progress in the use of SAA in the setting of unrelated donor transplants, which now provide outcomes similar, though still not identical, to HLA-identical sibling transplants. Recent data on stem cell source, conditioning regimens, and graft-versus-host disease prophylaxis are outlined. Other donor types such as cord blood and haploidentical mismatched family donors are also discussed.
authors.affiliation: Division of Hematology and Bone Marrow Transplant Unit, IRCCS San Martino, Pzza R Bensi 1, Genova 16132, Italy. Electronic address: andrea.bacigalupo@hsanmartino.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bacigalupo
mesh_terms: D000741:Anemia, Aplastic / Q000473:pathology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006650:Histocompatibility Testing; D006801:Humans; D012720:Severity of Illness Index; D035781:Siblings; D016019:Survival Analysis; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods
keywords: Acquired severe aplastic anemia; Bone marrow transplantation; Graft-versus-host disease; Unrelated donors