title: miRNA expression is highly sensitive to a drug therapy in Parkinson's disease.
abstract: BACKGROUND
  miRNAs may play a role in the pathogenesis of Parkinson's disease. It is necessary to continue the search for new miRNAs that may affect the development of neurodegeneration in Parkinson's disease.
  
  
  METHODS
  20 untreated patients with Parkinson's disease and 18 treated patients with Parkinson's disease (Hoehn and Yahr scores 1-2) were studied. An analysis of the levels of 11 miRNAs in the peripheral blood lymphocytes of patients was carried out using reverse transcription followed by real-time PCR.
  
  
  RESULTS
  The levels of miR-7, miR-9-3p, miR-9-5p, miR-129, and miR-132 were increased by more than three times in treated patients with Parkinson's disease compared with those of the controls.
  
  
  CONCLUSIONS
  It is probable that miRNAs are very sensitive to drug therapy and that the effects of therapy observed may be associated with changes in the levels of these miRNAs and their target genes in patients with Parkinson's disease.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia. Electronic address: anelja.a@gmail.com.
authors.forename: Anelya Kh
authors.initials: AKh
authors.lastname: Alieva
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Filatova
authors.affiliation: Research Centre of Neurology, Volokolamskoe Shosse 80, Moscow 125367, Russia.
authors.forename: Aleksey V
authors.initials: AV
authors.lastname: Karabanov
authors.affiliation: Research Centre of Neurology, Volokolamskoe Shosse 80, Moscow 125367, Russia.
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Illarioshkin
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Limborska
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Shadrina
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Petr A
authors.initials: PA
authors.lastname: Slominsky
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000978:Antiparkinson Agents; D035683:MicroRNAs
keywords: Parkinson's disease; Peripheral blood; microRNAs