title: Identification of the first imported KPC-3 Klebsiella pneumoniae from the USA to Taiwan.
abstract: Establishment of KPC-associated genes into a new region usually requires travellers with hospital admission and their carriage into the communities. In this report, a worldwide spreading clone carrying KPC-3 was isolated from the sputum of a hospitalised patient with a serious infection who had just come from the USA and had been admitted to a New York hospital. By genetic comparison with a strain isolated from New Jersey (NJ-KPC-21), this isolate from the traveller was genetically related. The blaKPC-3 gene was harboured on a large plasmid with a complex structure of a Tn3-based transposon, Tn4401a. The KPC-3-carrying plasmid was very similar (>99.9% identity) to the 113 637-bp blaKPC-3-encoding plasmid pKpQIL that originated from the 2006 epidemic carbapenem-resistant Klebsiella pneumoniae outbreak in Israel. With the first recognition of KPC-2 in 2011 and continuing spread, physicians should be aware of the coming of KPC-3 K. pneumoniae in Taiwan.
authors.affiliation: Departments of Medicine, Chi Mei Medical Center, Liu Ying, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy & Science, Tainan, Taiwan.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Tang
authors.affiliation: Institute of Genomics and Bioinformatics, and Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Ying-Tsong
authors.initials: YT
authors.lastname: Chen
authors.affiliation: AIDS Healthcare Foundation, Los Angeles, CA, USA; Department of Infectious Diseases, Veterans Affairs New Jersey Healthcare System, East Orange, NJ, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Chiang
authors.affiliation: Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Chang-Phone
authors.initials: CP
authors.lastname: Fung
authors.affiliation: Departments of Medicine, Chi Mei Medical Center, Liu Ying, Tainan, Taiwan.
authors.forename: Yin-Ching
authors.initials: YC
authors.lastname: Chuang
authors.affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan. Electronic address: klksiu@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Kristopher Siu
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009518:New York; D010957:Plasmids; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013624:Taiwan; D014195:Travel; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae
keywords: KPC-3, Klebsiella pneumoniae; Taiwan