title: Initial operative treatment of isolated ileal Crohn's disease in adolescents.
abstract: BACKGROUND
  We hypothesize that in children with Crohn's disease (CD) isolated to a single site, resection leads to clinical improvement, decreased medication requirements, and improved growth.
  
  
  METHODS
  A retrospective review was conducted of children with CD isolated to the terminal ileum undergoing operative intervention at Children's Hospital Colorado between 2002 and 2013.
  
  
  RESULTS
  Twenty-six patients underwent ileocecetomy (mean age at diagnosis 14.1 ± 2.6 years; mean age at resection 15.7 ± 2.5 years; median follow-up 2 ± 1.5 years). Twenty-two (84.6%) patients reported clinical improvement and 17 (65.4%) were able to decrease the number or dosage of medications. Average weight increased from the 29th to the 45th percentile (P = .09) at 1 year and to the 56th percentile (P = .02) at 3 years post resection. Average body mass index increased from the 30th to the 48th and 49th percentile at 1 and 3 years (P < .05 for both), respectively. Height increased from the 39th percentile at the time of resection to the 51st percentile at 3 years (P = nonsignificant).
  
  
  CONCLUSIONS
  Surgical resection of an isolated ileal segment in adolescents with CD allows for catch-up growth and reduction in medication requirements.
authors.affiliation: Department of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Division of Surgery, University of Colorado, School of Medicine, Aurora, CO 80045, USA. Electronic address: Ann.kulungowski@childrenscolorado.org.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Kulungowski
authors.affiliation: Department of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Division of Surgery, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Acker
authors.affiliation: Department of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Department of Pediatrics, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Hoffenberg
authors.affiliation: Department of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Department of Pediatrics, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Neigut
authors.affiliation: Department of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Division of Surgery, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Partrick
mesh_terms: D000293:Adolescent; D003424:Crohn Disease / Q000601:surgery*; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000601:surgery*; D008297:Male; D012189:Retrospective Studies
keywords: Crohn's disease; Inflammatory bowel disease; Intestine; Pediatrics; Surgery