title: [Antimutagenesis of multiphytoadaptogene in yeast saccharomyces].
abstract: Multiphytoadaptogene (MPA) consists of plant extracts components including adaptogenes. Genotoxicity analysis revealed the antimutagenic activity of MPA. MPA decreased the direct mutations frequency in ADE4-ADE8 loci induced by UV radiation and nitrous acid by 3.7 and 33 times, respectively. The lethal effect of UV radiation was inhibited when the preparation was used. MPA had no effect on replicative mutagenesis. At the same time it depressed mutagenesis caused by repair errors. The data obtained suggest the antimutagenic activity of multiphytoadaptogene is associated with postreplicative repair activation.
authors.forename: O N
authors.initials: ON
authors.lastname: Kurennaya
authors.forename: R V
authors.initials: RV
authors.lastname: Karpova
authors.forename: O A
authors.initials: OA
authors.lastname: Bocharova
authors.forename: I V
authors.initials: IV
authors.lastname: Kazeev
authors.forename: E V
authors.initials: EV
authors.lastname: Bocharov
authors.forename: V G
authors.initials: VG
authors.lastname: Korolev
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair; D059645:Mutation Rate; D009608:Nitrous Acid / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D014466:Ultraviolet Rays
chemical_list: D016587:Antimutagenic Agents; D010936:Plant Extracts; D029701:Saccharomyces cerevisiae Proteins; D009608:Nitrous Acid