title: [Polyunsaturated omega-3 fatty acids and systemic lupus erythematosus: what do we know?].
abstract: Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Therefore, the supplementation of these types of lipids may represent additional option treatment for chronic systemic diseases, such as Systemic Lupus Erythematous and other rheumatic diseases. The role of these lipids has not been well established, yet. However, it seems there is a direct relationship between its intake and the decrease of the disease clinical manifestations as well as of the inflammatory status of the patients. Thus, the aim of this manuscript is to present a thorough review on the effects of omega-3 fatty acids in patients with SLE. Bibliographic data set as the Medical Literature Analysis and Retrieval System Online (MEDLINE) and Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) were searched using as key words: systemic lupus erythematous (SLE), polyunsaturated fatty acids omega-3, eicosapentanoic acid (EPA), docosahexanoic acid (DHA), antioxidants and diet. Manuscripts published up to September 2013 were included. There were 43 articles related to the topic, however only 15 pertained human studies, with three review articles and 12 clinical studies.
authors.affiliation: Programa de Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. Electronic address: maricurado@gmail.com.
authors.forename: Mariane Curado
authors.initials: MC
authors.lastname: Borges
authors.affiliation: Programa de Ciências Aplicadas à Saúde do Adulto, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil; Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Fabiana de Miranda Moura
authors.initials: Fde M
authors.lastname: Santos
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Rosa Weiss
authors.initials: RW
authors.lastname: Telles
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Maria Isabel Toulson Davisson
authors.initials: MI
authors.lastname: Correia
authors.affiliation: Departamento do Aparelho Locomotor, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Cristina Costa Duarte
authors.initials: CC
authors.lastname: Lanna
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3
keywords: Antioxidantes; Antioxidants and diet; Docosahexanoic acid (DHA); Eicosapentanoic acid (EPA); Lúpus eritematoso sistêmico (LES); Polyunsaturated fatty acids omega‐3; Systemic lupus erythematous (SLE); Ácido docosahexaenoico (DHA); Ácido eicosapentaenoico (EPA); Ácidos graxos poli‐insaturados ômega‐3