title: Association between interleukin-4 polymorphisms and environment and nonsmall cell lung cancer in Chinese population.
abstract: OBJECTIVE
  The aim was to evaluate the influence of interleukin (IL)-4-590 C/T gene polymorphism in the susceptibility to nonsmall cell lung cancer (NSCLC), whether the environment also affects genetic polymorphisms.
  
  
  METHODS
  A case-control study was conducted with 500 NSCLC patients and 500 healthy controls, matched on age and gender. The single nucleotide polymorphisms distributed in IL-4 gene were selected for genotyping. The association between genotype and NSCLC risk was evaluated by computing the odds ratio and 95% confidence interval with multivariate unconditional logistic regression analyses.
  
  
  RESULTS
  The allele frequencies were not associated with NSCLC regardless of histological type or gender. The genotype distributions were similar between cases and controls, between adenocarcinoma patients and controls, and between male squamous-cell carcinoma (SCC) patients and male controls. However, genotype (C/C + C/T) frequencies polymorphism of rs2243250 were different between female SCC patients and female controls.
  
  
  CONCLUSIONS
  These results suggest that environmental agents might have the potential for interacting with human genetic polymorphisms in NSCLC. IL-4-590 C/T polymorphism (C/C + C/T frequencies) may be a potential susceptibility marker for female SCC patients in China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Gu
authors.forename: Yingying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: C508598:IL4 protein, human; D015847:Interleukin-4