title: [Adipose-derived stromal cells: history, isolation, immunomodulatory properties and clinical perspectives].
abstract: Over the last decade, the clinical use of adipose-derived stromal/stem cells (ASC) in regenerative medicine is rapidly increasing. ASC belong to the mesenchymal stromal cells initially obtained from the bone marrow. Their limited differentiation capacity in vivo into functional mature cells has led to a reassessment of their mechanisms of action. One of the major clinical interests appears related to paracrine effects through a temporary production of trophic and immunomodulatory factors. Our purpose is to provide a review on the latest knowledge in the field of ASC, mechanisms of action, mainly immunomodulatory/immunosuppressive properties, methods of obtention, with a focus on clinical perspectives particularly in the field of cellular therapy and fat grafting technique in plastic surgery.
authors.affiliation: Service de chirurgie plastique et reconstructrice, université de Rennes 1, hôpital Sud, 16, boulevard de Bulgarie, 35200 Rennes, France; Inserm U917, université de Rennes 1, 35033 Rennes, France; Laboratoire SITI, établissement français du sang Bretagne, CHU de Rennes, 35033 Rennes, France; STROMAlab, UMR5273 CNRS/UPS/EFS, Inserm U1031, hôpital Rangueil, Toulouse, France. Electronic address: nbertheuil@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Bertheuil
authors.affiliation: STROMAlab, UMR5273 CNRS/UPS/EFS, Inserm U1031, hôpital Rangueil, Toulouse, France; Service de chirurgie plastique, reconstructrice et esthétique, université Paul-Sabatier, hôpital Rangueil, 31059 Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Chaput
authors.affiliation: Inserm U917, université de Rennes 1, 35033 Rennes, France; Laboratoire SITI, établissement français du sang Bretagne, CHU de Rennes, 35033 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Ménard
authors.affiliation: STROMAlab, UMR5273 CNRS/UPS/EFS, Inserm U1031, hôpital Rangueil, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Varin
authors.affiliation: Service de chirurgie plastique, reconstructrice et esthétique, université Paul-Sabatier, hôpital Rangueil, 31059 Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Garrido
authors.affiliation: Service de chirurgie plastique, reconstructrice et esthétique, université Paul-Sabatier, hôpital Rangueil, 31059 Toulouse, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Grolleau
authors.affiliation: STROMAlab, UMR5273 CNRS/UPS/EFS, Inserm U1031, hôpital Rangueil, Toulouse, France.
authors.forename: L
authors.initials: L
authors.lastname: Sensébé
authors.affiliation: Service de chirurgie plastique et reconstructrice, université de Rennes 1, hôpital Sud, 16, boulevard de Bulgarie, 35200 Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Watier
authors.affiliation: Inserm U917, université de Rennes 1, 35033 Rennes, France; Laboratoire SITI, établissement français du sang Bretagne, CHU de Rennes, 35033 Rennes, France.
authors.forename: K
authors.initials: K
authors.lastname: Tarte
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D006801:Humans; D056747:Immunomodulation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine
keywords: Anti-inflammatory effect; Cellules stromales mésenchymateuses; Fraction vasculaire stromale; Immunosuppression; Mesenchymal stromal cells; Médecine régénérative; Propriétés anti-inflammatoires; Regenerative medicine; Stromal vascular fraction