title: Allogeneic stem cell transplantation for thalassemia major.
abstract: Allogeneic stem cell transplant remains the only curative option for β-thalassemia major. In patients with good risk features it is reasonable to anticipate a greater than 90% chance of a successful transplant outcome. The conventional risk stratification system has limitations and alternative systems are being explored to better identify subsets that require innovative approaches. Several novel regimens have been evaluated to reduce treatment-related morbidity and mortality. There remain challenges in improving the clinical outcome of high-risk patients. There are limited data on the role of splenectomy before transplantation or optimal posttransplant chelation and care of these patients.
authors.affiliation: Department of Haematology, Christian Medical College, Ida Scudder Road, Vellore, TN 632004, India. Electronic address: vikram@cmcvellore.ac.in.
authors.forename: Vikram
authors.initials: V
authors.lastname: Mathews
authors.affiliation: Department of Haematology, Christian Medical College, Ida Scudder Road, Vellore, TN 632004, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Department of Haematology and Bone Marrow Transplant, Tata Medical Center, Rajarhat, Kolkata 700020, India.
authors.forename: Mammen
authors.initials: M
authors.lastname: Chandy
mesh_terms: D016026:Bone Marrow Transplantation; D018572:Disease-Free Survival; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000628:therapy*
keywords: Allogeneic stem cell transplant; Conditioning regimens; Cord blood stem cells; Haploidentical transplants; Peripheral blood stem cell graft; Sinusoidal obstruction syndrome; Thalassemia major; Treosulfan