title: Allogeneic and autologous mode of stem cell transplantation in regenerative medicine: which way to go?
abstract: Stem cell transplantation is a generic term covering different techniques. However there is argument over the pros and cons of autologous and allogeneic transplants of mesenchymal stem cells (MSCs) for regenerative therapy. Given that the MSCs have already been proven to be safe in patients, we hypothesize that allogeneic transplantation could be more effective and cost-effective as compared to autologous transplantation specifically in older subjects who are the likely victims of degenerative diseases. This analysis is based on the scientific logic that allogeneic stem cells extracted in large numbers from young and healthy donors could be physiologically, metabolically and genetically more stable. Therefore stem cells from young donors may be expected to exhibit higher vigor in secreting trophic factors leading to activation of host tissue-specific stem cells and also be more efficient in remodeling the micro-environmental niche of damaged tissue.
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India.
authors.forename: Murali Krishna
authors.initials: MK
authors.lastname: Mamidi
authors.affiliation: Department of Anesthesiology, Taylor's University Clinical School, Sungai Buloh Hospital, Selangor, Malaysia.
authors.forename: Susmita
authors.initials: S
authors.lastname: Dutta
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Bhonde
authors.affiliation: Department of Surgery, Taylor's University Clinical School, Sungai Buloh Hospital, Selangor, Malaysia. Electronic address: akdcts@yahoo.com.
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Das
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India. Electronic address: rajarshi.pal@manipal.edu.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Pal
mesh_terms: D000367:Age Factors; D064591:Allografts; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D016922:Cellular Senescence; D003362:Cost-Benefit Analysis; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics / Q000379:methods; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D017382:Reactive Oxygen Species / Q000378:metabolism; D044968:Regenerative Medicine / Q000191:economics / Q000379:methods*; D015398:Signal Transduction; D033581:Stem Cell Transplantation / Q000191:economics / Q000379:methods*; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D017382:Reactive Oxygen Species