title: Updating memories--the role of prediction errors in memory reconsolidation.
abstract: Memories are not static imprints of past experience, but rather are dynamic entities which enable us to predict outcomes of future situations and inform appropriate behaviours. In order to maintain the relevance of existing memories to our daily lives, memories can be updated with new information via a process of reconsolidation. In this review we describe recent experimental advances in the reconsolidation of both appetitive and aversive memory, and explore the neuronal mechanisms that underpin the conditions under which reconsolidation will occur. We propose that a prediction error signal, originating from dopaminergic midbrain neurons, is necessary for destabilisation and subsequent reconsolidation of a memory.
authors.affiliation: School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Marc T J
authors.initials: MT
authors.lastname: Exton-McGuinness
authors.affiliation: School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Jonathan L C
authors.initials: JL
authors.lastname: Lee
authors.affiliation: School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom; School of Psychology, University of New South Wales, Kensington, Sydney 2052, NSW, Australia. Electronic address: a.reichelt@unsw.edu.au.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Reichelt
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D006040:Goals; D006801:Humans; D008568:Memory / Q000502:physiology*; D008636:Mesencephalon / Q000166:cytology; D009046:Motor Neurons / Q000502:physiology; D062308:Optogenetics; D011237:Predictive Value of Tests; D012201:Reward
chemical_list: D004298:Dopamine
keywords: Dopamine; Memory; NMDAR; Prediction error; Reconsolidation