title: Comparison of gastric cancer surgery between patients aged >80 years and <79 years: complications and multivariate analysis of prognostic factors.
abstract: OBJECTIVE
  To evaluate the clinicopathological features and results of surgery for gastric cancer in elderly patients aged ˃80 years relative to those aged ˂79 years, and to recommend the appropriate surgical treatment for elderly patients.
  
  
  METHODS
  A total of 332 patients with gastric cancer who underwent gastrectomy in our department between 2002 and 2012 were evaluated. Of these, 81 were aged ˃80 years (Group A) and 251 were aged ˂79 years (Group B). We compared surgical outcomes and survival in these two groups. RESULTS; Postopeartive complications were associated with preoperative cormorbid disease(p<0.01). D2 and R0 resection was common in GroupB (p<0.01). Respiratory complications and hospital deaths were higher in Group A than in Group B. Overall survival (OS) was significantly lower in Group A than in Group B. Regarding Stage I disease, OS was significantly lower in Group A; however, cause-specific survival was similar between the two groups. Multivariate analysis showed that radicality and postoperative complications were independent prognostic factors for OS in elderly gastric cancer patients.
  
  
  CONCLUSIONS
  These results indicate that postoperative respiratory complications and other causes of death worsened the prognosis of elderly. Preoperative accurate judgment of co-morbid disease, meticulous postoperative management and follow up might be improved survival of gastric cancer in elderly.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsujie
authors.forename: Johji
authors.initials: J
authors.lastname: Hara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kato
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kitani
authors.forename: Sayuri
authors.initials: S
authors.lastname: Isono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeyama
authors.forename: Masao
authors.initials: M
authors.lastname: Yukawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inoue
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kanaizumi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome