title: Growth plate stress distribution implications during bone development: a simple framework computational approach.
abstract: Mechanical stimuli play a significant role in the process of long bone development as evidenced by clinical observations and in vivo studies. Up to now approaches to understand stimuli characteristics have been limited to the first stages of epiphyseal development. Furthermore, growth plate mechanical behavior has not been widely studied. In order to better understand mechanical influences on bone growth, we used Carter and Wong biomechanical approximation to analyze growth plate mechanical behavior, and explore stress patterns for different morphological stages of the growth plate. To the best of our knowledge this work is the first attempt to study stress distribution on growth plate during different possible stages of bone development, from gestation to adolescence. Stress distribution analysis on the epiphysis and growth plate was performed using axisymmetric (3D) finite element analysis in a simplified generic epiphyseal geometry using a linear elastic model as the first approximation. We took into account different growth plate locations, morphologies and widths, as well as different epiphyseal developmental stages. We found stress distribution during bone development established osteogenic index patterns that seem to influence locally epiphyseal structures growth and coincide with growth plate histological arrangement.
authors.affiliation: Institute for the Study of Inborn Errors of Metabolism, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: J M
authors.initials: JM
authors.lastname: Guevara
authors.affiliation: Biomimetics Laboratory and Numerical Methods and Modeling Research Group (GNUM), Instituto de Biotecnología (IBUN), Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: M A
authors.initials: MA
authors.lastname: Moncayo
authors.affiliation: Biomimetics Laboratory and Numerical Methods and Modeling Research Group (GNUM), Instituto de Biotecnología (IBUN), Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: J J
authors.initials: JJ
authors.lastname: Vaca-González
authors.affiliation: Biomimetics Laboratory and Numerical Methods and Modeling Research Group (GNUM), Instituto de Biotecnología (IBUN), Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: M L
authors.initials: ML
authors.lastname: Gutiérrez
authors.affiliation: Institute for the Study of Inborn Errors of Metabolism, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: L A
authors.initials: LA
authors.lastname: Barrera
authors.affiliation: Biomimetics Laboratory and Numerical Methods and Modeling Research Group (GNUM), Instituto de Biotecnología (IBUN), Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address: dagarzona@unal.edu.co.
authors.forename: D A
authors.initials: DA
authors.lastname: Garzón-Alvarado
mesh_terms: D000293:Adolescent; D001846:Bone Development / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004838:Epiphyses / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D005260:Female; D020342:Finite Element Analysis; D006132:Growth Plate / Q000196:embryology / Q000254:growth & development* / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D008954:Models, Biological; D010012:Osteogenesis / Q000502:physiology; D011247:Pregnancy; D013314:Stress, Mechanical
keywords: Epiphyseal stress distribution; Growth plate; Long bone development; Mechanical stimulus