title: Simplified Selvester Score: a practical electrocardiographic instrument to predict response to CRT.
abstract: OBJECTIVE
  To investigate the LBBB Selvester Scoring System (LBBB-SSc) and the Simplified-SSc prognostic impact in predicting response to CRT, all cause and cardiac mortality, heart failure (HF) hospitalizations and onset of arrhythmias in HF patients undergoing CRT.
  
  
  METHODS
  We retrospectively evaluated LBBB-SSc and Simplified-SSc of 172 consecutive HF patients with true-LBBB who underwent CRT. Response to CRT was defined as the improvement of LVEF of at least 10% or as the reduction of LVESV of at least 15% at 6-month follow-up. Logistic regression analysis and Cox proportional hazard analysis were performed to evaluate each endpoint related risk according to LBBB-SSc and Simplified-SSc.
  
  
  RESULTS
  The LBBB-SSc and the Simplified-SSc were inversely correlated with response to CRT. Myocardial scar at both scores was independently associated to non-response to CRT. No correlation was observed between LBBB-SSc or Simplified-SSc and other endpoints.
  
  
  CONCLUSIONS
  In HF patients with true-LBBB, Simplified-SSc is able to predict response to CRT.
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Bani
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy. Electronic address: checchi.luca@gmail.com.
authors.forename: Luca
authors.initials: L
authors.lastname: Checchi
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Cartei
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pieragnoli
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ricciardi
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Paoletti Perini
authors.affiliation: Department of Cardiology, University of Siena, Siena, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Padeletti
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Michelotti
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Michelucci
authors.affiliation: Department of Cardiology, Cliniche Gavazzeni, Bergamo, Italy.
authors.forename: Giosuè
authors.initials: G
authors.lastname: Mascioli
authors.affiliation: Department of Cardiology, University of Florence, Florence, Italy; Department of Cardiology, Cliniche Gavazzeni, Bergamo, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Padeletti
mesh_terms: D000368:Aged; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy*; D058406:Cardiac Resynchronization Therapy / Q000401:mortality*; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Cardiac Resynchronization Therapy; Heart failure; Myocardial fibrosis; Reverse remodeling; Selvester QRS Score