title: Use of gonadotropin-releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  Forty women with PCOS and 74 hyper-responders without PCOS.
  
  
  METHODS
  GnRHa trigger.
  
  
  METHODS
  Number of oocytes.
  
  
  RESULTS
  Serum E2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS).
  
  
  CONCLUSIONS
  The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: O'Neill
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address: Suneeta.Senapati@uphs.upenn.edu.
authors.forename: Suneeta
authors.initials: S
authors.lastname: Senapati
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Anuja
authors.initials: A
authors.lastname: Dokras
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000628:therapy*; D009865:Oocytes / Q000187:drug effects / Q000473:pathology*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone
keywords: GnRHa trigger; IVF outcomes; OHSS; PCOS