title: Pleural liquid and kinetic friction coefficient of mesothelium after mechanical ventilation.
abstract: Volume and protein concentration of pleural liquid in anesthetized rabbits after 1 or 3h of mechanical ventilation, with alveolar pressure equal to atmospheric at end expiration, were compared to those occurring after spontaneous breathing. Moreover, coefficient of kinetic friction between samples of visceral and parietal pleura, obtained after spontaneous or mechanical ventilation, sliding in vitro at physiological velocity under physiological load, was determined. Volume of pleural liquid after mechanical ventilation was similar to that previously found during spontaneous ventilation. This finding is contrary to expectation of Moriondo et al. (2005), based on measurement of lymphatic and interstitial pressure. Protein concentration of pleural liquid after mechanical ventilation was also similar to that occurring after spontaneous ventilation. Coefficient of kinetic friction after mechanical ventilation was 0.023±0.001, similar to that obtained after spontaneous breathing.
authors.affiliation: Dipartimento di Fisiopatologia e dei Trapianti, Sezione di Fisiologia Umana, Università degli Studi di Milano, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bodega
authors.affiliation: Dipartimento di Fisiopatologia e dei Trapianti, Sezione di Fisiologia Umana, Università degli Studi di Milano, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sironi
authors.affiliation: Dipartimento di Fisiopatologia e dei Trapianti, Sezione di Fisiologia Umana, Università degli Studi di Milano, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Porta
authors.affiliation: Dipartimento di Fisiopatologia e dei Trapianti, Sezione di Fisiologia Umana, Università degli Studi di Milano, Milan, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Zocchi
authors.affiliation: Dipartimento di Fisiopatologia e dei Trapianti, Sezione di Fisiologia Umana, Università degli Studi di Milano, Milan, Italy. Electronic address: emilio.agostoni@unimi.it.
authors.forename: Emilio
authors.initials: E
authors.lastname: Agostoni
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D004848:Epithelium / Q000502:physiology*; D017276:Friction / Q000502:physiology*; D016014:Linear Models; D055595:Mechanical Phenomena; D010994:Pleura / Q000502:physiology*; D011817:Rabbits; D012119:Respiration; D012121:Respiration, Artificial
keywords: Friction coefficient; Mechanical ventilation; Pleural liquid; Pleural mesothelium; Rabbit; Spontaneous breathing