title: Differential expression of genes linked to the leukemia inhibitor factor signaling pathway during the estrus cycle and early pregnancy in the porcine endometrium.
abstract: The objective of this study was to determine the expression profiles of leukemia inhibitory factor (LIF) and its receptor (LIFR), interleukin 6 receptor (IL6R), tumor protein p53 (TP53) and B-cell CLL/lymphoma 2 (BCL2) in the porcine endometrium on selected days of the estrous cycle and pregnancy. Time- and reproductive status (estrous cycle/pregnancy)-specific patterns of expression were identified for all investigated genes. The most pronounced changes were seen on Days 12 and 14 of pregnancy when maternal recognition of pregnancy and implantation, respectively, occurs in pigs.
authors.affiliation: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland; Department for Large Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland. Electronic address: m.kaczmarek@pan.olsztyn.pl.
authors.forename: Monika M
authors.initials: MM
authors.lastname: Kaczmarek
authors.affiliation: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Krawczynski
authors.affiliation: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Najmula
authors.affiliation: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
authors.forename: Zaneta P
authors.initials: ZP
authors.lastname: Reliszko
authors.affiliation: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Sikora
authors.affiliation: Department for Large Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland.
authors.forename: Zdzislaw
authors.initials: Z
authors.lastname: Gajewski
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004717:Endometrium / Q000378:metabolism / Q000502:physiology*; D030762:Estrous Cycle / Q000378:metabolism / Q000502:physiology*; D005260:Female; D020869:Gene Expression Profiling / Q000662:veterinary; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D053605:Leukemia Inhibitory Factor / Q000378:metabolism*; D011247:Pregnancy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D053606:Receptors, OSM-LIF / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013552:Swine / Q000378:metabolism / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D053605:Leukemia Inhibitory Factor; D019253:Proto-Oncogene Proteins c-bcl-2; D019947:Receptors, Interleukin-6; D053606:Receptors, OSM-LIF; D016159:Tumor Suppressor Protein p53
keywords: BCL2; IL6R; LIF; LIFR; Pig; TP53