title: Concurrent and lasting effects of emotion regulation on amygdala response in adolescence and young adulthood.
abstract: This study used functional MRI (fMRI) to examine a novel aspect of emotion regulation in adolescent development: whether age predicts differences in both the concurrent and lasting effects of emotion regulation on amygdala response. In the first, active regulation, phase of the testing session, fMRI data were collected while 56 healthy individuals (age range: 10.50-22.92 years) reappraised aversive stimuli so as to diminish negative responses to them. After a short delay, the second, re-presentation, phase involved passively viewing the aversive images from the reappraisal task. During active regulation, older individuals showed greater drops in negative affect and inverse rostrolateral prefrontal-amygdala connectivity. During re-presentation, older individuals continued to show lasting reductions in the amygdala response to aversive stimuli they had previously reappraised, an effect mediated by rostrolateral PFC. These data suggest that one source of heightened emotionality in adolescence is a diminished ability to cognitively down-regulate aversive reactions.
authors.affiliation: Department of Psychology, Columbia University, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Silvers
authors.affiliation: Department of Psychology, Columbia University, USA.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Shu
authors.affiliation: Department of Psychology, Columbia University, USA.
authors.forename: Alexa D
authors.initials: AD
authors.lastname: Hubbard
authors.affiliation: Department of Psychology, Columbia University, USA.
authors.forename: Jochen
authors.initials: J
authors.lastname: Weber
authors.affiliation: Department of Psychology, Columbia University, USA.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Ochsner
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000375:Aging / Q000523:psychology*; D000679:Amygdala / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D055815:Young Adult
chemical_list: D010100:Oxygen