title: Ileal ganglioneuromatosis in a piglet: histopathological and immunohistochemical studies.
abstract: Ganglioneuromatosis (GNM) is a rare condition characterized by the benign proliferation of ganglion cells, nerve fibres and supporting cells of the enteric nervous system. Necropsy examination of a female piglet weighing 4 kg revealed a well-demarcated 20 cm segment of terminal ileum with thickening of the wall. Microscopically, the lamina propria was infiltrated by enteric glial cells and large ganglion cells. Within the submucosal and muscular layers, aggregates of neurons were interlaced by Schwann cells and enteric glial cells arranged in concentric rings. Immunohistochemically, the neurons were weakly labelled for S-100 and neuron-specific enolase, Schwann cells expressed S-100 and vimentin and enteric glial cells expressed glial fibrillary acidic protein and S-100. Pathological and immunohistochemical findings supported the diagnosis of ileal GNM.
authors.affiliation: Department of Veterinary Pathology, Faculty of Veterinary Science, La Plata National University, cc 296, B1900AVW, La Plata, Buenos Aires, Argentina.
authors.forename: M A
authors.initials: MA
authors.lastname: Quiroga
authors.forename: M I
authors.initials: MI
authors.lastname: Lozada
authors.forename: G
authors.initials: G
authors.lastname: Madariaga
authors.forename: J A
authors.initials: JA
authors.lastname: Cappucio
authors.forename: M A
authors.initials: MA
authors.lastname: Machuca
authors.forename: H
authors.initials: H
authors.lastname: Barrales
authors.forename: E M
authors.initials: EM
authors.lastname: Perez
authors.forename: C J
authors.initials: CJ
authors.lastname: Perfumo
mesh_terms: D000818:Animals; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology / Q000662:veterinary*; D007078:Ileal Neoplasms / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D034421:Sus scrofa; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*