title: Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand.
abstract: The toxicity of cyanide is hitherto attributed to its ability to bind to heme proteins' active site and thereby inhibit their activity. It is shown herein that the long-held interpretation is inadequate to explain several observations in heme-enzyme reaction systems. Generation of cyanide-based diffusible radicals in heme-enzyme reaction milieu could shunt electron transfers (by non-active site processes), and thus be detrimental to the efficiency of oxidative outcomes.
authors.affiliation: Center for Biomedical Research, VIT University, Vellore, Tamil Nadu, 632014 India.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Parashar
authors.affiliation: REDOx Lab, PSG Institute of Advanced Studies, Avinashi Road, Peelamedu, Coimbatore, Tamil Nadu, 641004, India.
authors.forename: Avanthika
authors.initials: A
authors.lastname: Venkatachalam
authors.affiliation: Center for Biomedical Research, VIT University, Vellore, Tamil Nadu, 632014 India.
authors.forename: Daniel Andrew
authors.initials: DA
authors.lastname: Gideon
authors.affiliation: REDOx Lab, PSG Institute of Advanced Studies, Avinashi Road, Peelamedu, Coimbatore, Tamil Nadu, 641004, India. Electronic address: satyamjayatu@yahoo.com.
authors.forename: Kelath Murali
authors.initials: KM
authors.lastname: Manoj
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D002417:Cattle; D002711:Chloride Peroxidase / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D004583:Electrons; D004798:Enzymes / Q000737:chemistry; D005609:Free Radicals; D005658:Fungi / Q000378:metabolism; D006418:Heme / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D008024:Ligands; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry; D010944:Plants / Q000378:metabolism; D011485:Protein Binding
chemical_list: D003486:Cyanides; D004798:Enzymes; D005609:Free Radicals; D008024:Ligands; D010545:Peroxides; D006418:Heme; D002711:Chloride Peroxidase; D010100:Oxygen
keywords: Cyanide; Dose-response; Heme-enzymes; Inhibition; Peroxidation