title: [Amyloidosis complicating spondyloarthropathies: Study of 15 cases].
abstract: OBJECTIVE
  Secondary amyloidosis (AA) is a rare complication of rheumatic diseases.
  
  
  OBJECTIVE
  The aim of this study was to determine the frequency of symptomatic amyloidosis AA in patients with spondyloarthropathy.
  
  
  METHODS
  Retrospective study (1984-2013). We reviewed the medical records of patients with spondyloarthropathy who had a histological diagnosis of amyloidosis AA (15 patients).
  
  
  RESULTS
  We identified 1.125 patients with spondyloarthropathies. Fifteen (1.3%) patients with amyloidosis AA were recruited. It was suspected in 14 patients (93.3%) because of nephrotic syndrome in most of them: 14 were symptomatic (93.3%): 5 (33.3%) ankylosing spondylitis (AS), 5 (33.3%) spondylitis associated with inflammatory bowel diseases (IBD), 4 (26.7%) psoriatic arthritis, and one (6.7%) reactive arthritis. The mean disease duration was 23.9 years. Mortality after one and 5 years of follow-up was 30 and 50% respectively.
  
  
  CONCLUSIONS
  The frequency of clinical amyloidosis AA in our patients was 1.3%. There was a marked male predominance, with AS or IBD. Clinical amyloidosis was diagnosed at a relatively late stage in spondyloarthropathy.
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: Sam63100@hotmail.com.
authors.forename: Samantha
authors.initials: S
authors.lastname: Rodríguez-Muguruza
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Melania
authors.initials: M
authors.lastname: Martínez-Morillo
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Holgado
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Xavier
authors.initials: X
authors.lastname: Saenz-Sarda
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateo
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Xavier
authors.initials: X
authors.lastname: Tena
authors.affiliation: Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Olivé
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D025242:Spondylarthropathies / Q000150:complications*
keywords: Amiloidosis secundaria; Espondiloartritis; Insuficiencia renal; Renal failure; Secondary amyloidosis; Spondyloarthropathy