title: 810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice.
abstract: We explored whether 810nm near-infrared light (NIr) offered neuroprotection and/or improvement in locomotor activity in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. Mice received MPTP and 810nm NIr treatments, or not, and were tested for locomotive activity in an open-field test. Thereafter, brains were aldehyde-fixed and processed for tyrosine hydroxylase immunohistochemistry. Our results showed that MPTP-treated mice that were irradiated with 810nm NIr had both greater locomotor activity (∼40%) and number of dopaminergic cells (∼20%) than those that were not. In summary, 810nm (as with 670nm) NIr offered neuroprotection and improved locomotor activity in MPTP-treated mice.
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: florian.reinhart@cea.fr.
authors.forename: Florian
authors.initials: F
authors.lastname: Reinhart
authors.affiliation: Department of Anatomy F13, University of Sydney, Sydney 2006, Australia. Electronic address: nabil.elmassri@sydney.edu.au.
authors.forename: Nabil El
authors.initials: NE
authors.lastname: Massri
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: fannie.darlot@cea.fr.
authors.forename: Fannie
authors.initials: F
authors.lastname: Darlot
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: napoleon.torres-martinez@cea.fr.
authors.forename: Napoleon
authors.initials: N
authors.lastname: Torres
authors.affiliation: Department of Physiology F13, University of Sydney, Sydney 2006, Australia. Electronic address: daniel.johnstone@sydney.edu.au.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Johnstone
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: cl.chabrol@cea.fr.
authors.forename: Claude
authors.initials: C
authors.lastname: Chabrol
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: thomas.costecalde@cea.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Costecalde
authors.affiliation: Department of Physiology F13, University of Sydney, Sydney 2006, Australia. Electronic address: jonathan.stone@sydney.edu.au.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Stone
authors.affiliation: Department of Anatomy F13, University of Sydney, Sydney 2006, Australia. Electronic address: john.mitrofanis@sydney.edu.au.
authors.forename: John
authors.initials: J
authors.lastname: Mitrofanis
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: alimlouis@sfr.fr.
authors.forename: Alim-Louis
authors.initials: AL
authors.lastname: Benabid
authors.affiliation: CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble, Alpes F38000, France. Electronic address: cecile.moro@cea.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Moro
mesh_terms: D000818:Animals; D002452:Cell Count; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000528:radiation effects*; D007259:Infrared Rays; D028022:Low-Level Light Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000528:radiation effects*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000532:radiotherapy*; D065842:Pars Compacta / Q000378:metabolism / Q000528:radiation effects*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
chemical_list: D014446:Tyrosine 3-Monooxygenase
keywords: Neuroprotection; Substantia nigra; Tyrosine hydroxylase