title: Immunohistochemical expression of mTOR in germinal center and nongerminal center group of diffuse large B-cell lymphoma: a clinicopathological study.
abstract: BACKGROUND
  The mammalian target of rapamycin (mTOR) pathway regulates many major cellular processes and is implicated in an increasing number of neoplasms, including lymphoma.
  
  
  METHODS
  We correlated immunohistochemical expression of mTOR with germinal center and nongerminal center phenotype, B cell lymphoma-2 (bcl-2) and cellular homolog of the retroviral v-myconcogene (c-myc) expression, and International Prognostic Index (IPI) score in 31 patients with diffuse large B-cell lymphoma (DLBCL).
  
  
  RESULTS
  Virtually all patients in our study with high mTOR scores had a germinal center phenotype. Furthermore within the germinal center subgroup, patients with high mTOR scores were associated with higher IPI scores (P < .001).
  
  
  CONCLUSIONS
  Based on our results we propose that within the category of germinal center phenotype of DLBCL, mTOR expression might help identify a subset of patients with potentially more aggressive tumors who might benefit from use of targeted therapy using mTOR inhibitors.
authors.affiliation: Department of Pathology, SUNY Upstate Medical University, Syracuse, NY. Electronic address: vajpayen@upstate.edu.
authors.forename: Neerja
authors.initials: N
authors.lastname: Vajpayee
authors.affiliation: Department of Pathology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY.
authors.forename: Richard
authors.initials: R
authors.lastname: Burack
authors.affiliation: Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Pathology, SUNY Upstate Medical University, Syracuse, NY.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hutchison
authors.affiliation: Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Gajra
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D018858:Germinal Center / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008221:Lymphoid Tissue / Q000378:metabolism* / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D058570:TOR Serine-Threonine Kinases
keywords: Germinal center and nongerminal center phenotype; Immunohistochemistry; International prognostic index; Prognostic markers; Targeted therapy