title: A reinvigorated era of bacterial secondary metabolite discovery.
abstract: Secondary metabolite discovery from bacteria has become increasingly successful in the last decade due to the advancement of integrated genetic-based, spectrometric-based and informatics-based techniques. Microbes and their unique metabolic outputs have been widely studied since the beginning of modern medicine; however, it is well known that the current repertoire of secondary metabolites, or more commonly natural products, is incomplete and the understanding of natural product-mediated intracellular dialog is in its infancy. Here, we highlight the present state of bacterial metabolomics including compound discovery approaches and new strategies for probing the role of these molecules within communication networks.
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Sidebottom
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405, USA; Department of Molecular and Cellular Biochemistry, Indiana University, 212 South Hawthorne Drive, Bloomington, IN 47405, USA; Present permanent address: Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA. Electronic address: carlsone@umn.edu.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Carlson
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D023281:Genomics / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D055432:Metabolomics / Q000379:methods*
chemical_list: D001688:Biological Products