title: Diffuse sclerosing osteomyelitis (DSO) of the mandible in SAPHO syndrome: a novel approach with anti-TNF therapy. Systematic review.
abstract: Diffuse sclerosing osteomyelitis of the mandible is now considered a local manifestation of SAPHO syndrome. This rare condition is thought to be of auto-inflammatory origin. The myriad of treatments shown in the literature, are basically empirical and reflect its unknown origin. We present a clinical case of refractory DSO treated with an anti-TNF drug (etanercept) with complete clinical remission. We advise against radical surgery and an interdisciplinary approach is recommended. A systematic literature review was also conducted.
authors.affiliation: Department of Oral and Maxillofacial Surgery (Head: Antonio Marí), University Hospital Bellvitge (HUB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain; Màster in Medicine, Surgery and Implantology (Directors: José López, Antonio Marí), University of Barcelona (UB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain. Electronic address: amari@bellvitgehospital.cat.
authors.forename: Antonio
authors.initials: A
authors.lastname: Marí
authors.affiliation: Department of Oral and Maxillofacial Surgery (Head: Antonio Marí), University Hospital Bellvitge (HUB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain; Màster in Medicine, Surgery and Implantology (Directors: José López, Antonio Marí), University of Barcelona (UB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Morla
authors.affiliation: Department of Oral and Maxillofacial Surgery (Head: Antonio Marí), University Hospital Bellvitge (HUB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain; Màster in Medicine, Surgery and Implantology (Directors: José López, Antonio Marí), University of Barcelona (UB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Melero
authors.affiliation: Màster in Medicine, Surgery and Implantology (Directors: José López, Antonio Marí), University of Barcelona (UB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Rocio
authors.initials: R
authors.lastname: Schiavone
authors.affiliation: Department of Rheumatology (Head: Joan Miquel Nolla), University Hospital Bellvitge (HUB), c/ Feixa Llarga, sn 08907 Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Rodríguez
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000068800:Etanercept / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007595:Joint Prosthesis; D008335:Mandibular Condyle / Q000601:surgery; D008336:Mandibular Diseases / Q000188:drug therapy* / Q000601:surgery; D063175:Mandibular Reconstruction / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy* / Q000601:surgery; D010026:Osteosclerosis / Q000188:drug therapy / Q000601:surgery; D012008:Recurrence; D012074:Remission Induction; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000068800:Etanercept
keywords: Anti-TNF; Diffuse sclerosing osteomyelitis; SHAPO syndrome