title: The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats.
abstract: OBJECTIVE
  The present study aimed to investigate the effects of the interaction between the abusive use of nandrolone decanoate (ND) and physical activity on the prostate structure of adult and older rats. We evaluated whether the use of ND, associated or not with physical exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate.
  
  
  METHODS
  Fifty-six male Sprague-Dawley rats were divided into eight groups. The animals were treated for eight weeks and divided into sedentary and trained groups, with or without ND use. Four groups were sacrificed 48 h after the end of the eight week experiment (adult groups), and four other groups were sacrificed at 300 days of age (older groups). The prostate was collected and processed for stereological and histopathological analysis and for the expression of AQP1 and VEGF by the Western blotting technique.
  
  
  RESULTS
  Both ND and physical activity altered the ventral prostate structure of the rats; the AQP1 and VEGF expression increased in young animals subjected to physical exercise.
  
  
  CONCLUSIONS
  Thus, it was concluded that the use of ND, associated or not with exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate.
authors.affiliation: Faculty of Medicine of Marília (FAMEMA), Marília, SP, Brazil.
authors.forename: João Simão
authors.initials: JS
authors.lastname: de Melo Neto
authors.affiliation: Department of Anatomy, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: de Campos Gomes
authors.affiliation: Department of Anatomy, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Patrícia Fernanda Felipe
authors.initials: PF
authors.lastname: Pinheiro
authors.affiliation: Department of Biological Sciences, School of Sciences, Univ Estadual Paulista (UNESP), Bauru, SP, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Pereira
authors.affiliation: Department of Morphology, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Wellerson Rodrigo
authors.initials: WR
authors.lastname: Scarano
authors.affiliation: Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Wagner José
authors.initials: WJ
authors.lastname: Fávaro
authors.affiliation: Department of Anatomy, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil. Electronic address: rdomeniconi@ibb.unesp.br.
authors.forename: Raquel Fantin
authors.initials: RF
authors.lastname: Domeniconi
mesh_terms: D000375:Aging / Q000502:physiology; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D051398:Aquaporin 1 / Q000096:biosynthesis; D001835:Body Weight / Q000187:drug effects; D004822:Epididymis / Q000378:metabolism; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D009929:Organ Size / Q000187:drug effects; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011467:Prostate / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012741:Sexual Maturation / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D045930:Anabolic Agents; D042461:Vascular Endothelial Growth Factor A; D051398:Aquaporin 1; D009277:Nandrolone; D000077603:Nandrolone Decanoate
keywords: AQP1; Anabolic; Resistance physical exercise; VEGF; Ventral prostate