title: Influence of titanium dioxide nanoparticles on  2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration  and toxicity in the marine fish European sea bass  (Dicentrarchus labrax).
abstract: The present study investigated the influence of nano-TiO(2) (1 mg L(-1)) on 2,3,7,8-tetrachlorodibenzo-p-dioxin(2,3,7,8-TCDD) (46 pg L(-1)) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano-TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.
authors.affiliation: Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy.
authors.forename: Camilla Della
authors.initials: CD
authors.lastname: Torre
authors.forename: Francesco
authors.initials: F
authors.lastname: Buonocore
authors.forename: Giada
authors.initials: G
authors.lastname: Frenzilli
authors.forename: Simonetta
authors.initials: S
authors.lastname: Corsolini
authors.forename: Andrea
authors.initials: A
authors.lastname: Brunelli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Guidi
authors.forename: Anton
authors.initials: A
authors.lastname: Kocan
authors.forename: Michela
authors.initials: M
authors.lastname: Mariottini
authors.forename: Filomena
authors.initials: F
authors.lastname: Mottola
authors.forename: Marco
authors.initials: M
authors.lastname: Nigro
authors.forename: Karla
authors.initials: K
authors.lastname: Pozo
authors.forename: Elisa
authors.initials: E
authors.lastname: Randelli
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Vannuccini
authors.forename: Simona
authors.initials: S
authors.lastname: Picchietti
authors.forename: Marianna
authors.initials: M
authors.lastname: Santonastaso
authors.forename: Vittoria
authors.initials: V
authors.lastname: Scarcelli
authors.forename: Silvano
authors.initials: S
authors.lastname: Focardi
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcomini
authors.forename: Lucia
authors.initials: L
authors.lastname: Rocco
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Scapigliati
authors.forename: Ilaria
authors.initials: I
authors.lastname: Corsi
mesh_terms: D000818:Animals; D001492:Bass; D004249:DNA Damage; D005880:Gills; D008099:Liver; D009132:Muscles; D053758:Nanoparticles / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism* / Q000633:toxicity; D012623:Seawater; D014025:Titanium / Q000633:toxicity*; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D014874:Water Pollutants, Chemical; C009495:titanium dioxide; D014025:Titanium