title: [Comparison of the effects of magnesium sulphate and dexmedetomidine on surgical vision quality in endoscopic sinus surgery: randomized clinical study].
abstract: OBJECTIVE
  Even a small amount of bleeding during endoscopic sinus surgery can corrupt the endoscopic field and complicate the procedure. Various techniques, including induced hypotension, can minimize bleeding during endoscopic sinus surgery. The aim of this study was to compare the surgical vision quality, haemodynamic parameters, postoperative pain, and other effects of magnesium, a hypotensive agent, with that of dexmedetomidine, which was initially developed for short-term sedation in the intensive care unit but also is an alpha 2 agonist sedative.
  
  
  METHODS
  60 patients between the ages of 18 and 45 years were divided into either the magnesium group (Group M) or the dexmedetomidine group (Group D). In Group M, magnesium sulphate was given at a pre-induction loading dose of 50mgkg(-1) over 10min and maintained at 15mgkg(-1)h(-1); in Group D, dexmedetomidine was given at 1mcgkg(-1) 10min before induction and maintained at 0.6mcgkg(-1)h(-1). Intraoperatively, the haemodynamic and respiratory parameters and 6-point intraoperative surgical field evaluation scale were recorded. During the postoperative period, an 11-point numerical pain scale, the Ramsay sedation scale, the nausea/vomiting scale, the adverse effects profile, and itching parameters were noted.
  
  
  RESULTS
  Group D showed a significant decrease in intraoperative surgical field evaluation scale scale score and heart rate. The average operation time was 50min, and Group M had a higher number of prolonged surgeries. No significant difference was found in the other parameters.
  
  
  CONCLUSIONS
  Due to its reduction of bleeding and heart rate in endoscopic sinus surgery and its positive impacts on the duration of surgery, we consider dexmedetomidine to be a good alternative to magnesium.
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia. Electronic address: akcanakkaya@hotmail.com.
authors.forename: Akcan
authors.initials: A
authors.lastname: Akkaya
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Umit Yasar
authors.initials: UY
authors.lastname: Tekelioglu
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Demirhan
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Murat
authors.initials: M
authors.lastname: Bilgi
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Isa
authors.initials: I
authors.lastname: Yildiz
authors.affiliation: Departamento de Cirurgia de Cabeça e Pescoço, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Apuhan
authors.affiliation: Departamento de Anestesiologia e Reanimação, Abant Izzet Baysal University Medical School, Bolu, Turquia.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kocoglu
keywords: Cirurgia endoscópica sinusal; Dexmedetomidina; Dexmedetomidine; Endoscopic sinus surgery; Hipotensão; Hypotension; Magnesium; Sulfato de Magnésio