title: Fifty ways to inhibit motility via cyclic di-GMP: the emerging Pseudomonas aeruginosa swarming story.
abstract: There are numerous ways by which cyclic dimeric GMP (c-di-GMP) inhibits motility. Kuchma et al. (S. L. Kuchma, N. J. Delalez, L. M. Filkins, E. A. Snavely, J. P. Armitage, and G. A. O'Toole, J. Bacteriol. 197:420-430, 2015, http://dx.doi.org/10.1128/JB.02130-14) offer a new, previously unseen way of swarming motility inhibition in Pseudomonas aeruginosa PA14. This bacterium possesses a single flagellum with one rotor and two sets of stators, only one of which can provide torque for swarming. The researchers discovered that elevated levels of c-di-GMP inhibit swarming by skewing stator selection in favor of the nonfunctional, "bad" stators.
authors.affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, USA linda-mccarter@uiowa.edu gomelsky@uwyo.edu.
authors.forename: Linda L
authors.initials: LL
authors.lastname: McCarter
authors.affiliation: Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, USA linda-mccarter@uiowa.edu gomelsky@uwyo.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: Gomelsky
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008124:Locomotion; D011550:Pseudomonas aeruginosa / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; C063010:MotA protein, Bacteria; C064779:MotB protein, Bacteria; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP