title: Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a Korean sponge Monanchora sp.
abstract: Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Tae Gu
authors.initials: TG
authors.lastname: Lee
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Patil
authors.forename: Bora
authors.initials: B
authors.lastname: Mun
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Yehee
authors.initials: Y
authors.lastname: Lee
authors.affiliation: ‡College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan, 712-749, Korea.
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.affiliation: §Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D056910:Republic of Korea; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D001643:Bridged Bicyclo Compounds; D015850:Interleukin-6; D008070:Lipopolysaccharides; D013256:Steroids; D014409:Tumor Necrosis Factor-alpha; C000598771:monanchosterol A; C000598772:monanchosterol B; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2