title: [Opposite Semax influence on conditioning and functional disturbances of avoidance responses in rats].
abstract: Semax effects on formation of active avoidance reaction in rats in different experimental models have been studied. It was shown that intraperitoneal Semax administration at a dose of 0.05 mg/kg accelerated acquisition of one-way active avoidance response when rats were trained to avoid electric foot-shock by jumping on the shelf. When rats were trained in shuttle-box the peptide increased the electroshock threshold value required to provocation of rat moving in experimental box and delayed acquisition of two-way active avoidance response. At the same time Semax stimulated avoidance response restoration in shuttle-box after functional disturbances induced by acute modification of cause-effect and spatial relationships in experimental environment. Data obtained support nootropic properties of Semax.
authors.forename: A N
authors.initials: AN
authors.lastname: Inozemtsev
authors.forename: A E
authors.initials: AE
authors.lastname: Agapitova
authors.forename: S B
authors.initials: SB
authors.lastname: Bokieva
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Glazova
authors.forename: N G
authors.initials: NG
authors.lastname: Levitskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskiĭ
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology*; D004597:Electroshock; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats
chemical_list: D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone