title: Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes.
abstract: A simple synthesis of 2-hydroxylated (E)-stilbenes was accomplished in good yields via oxidative coupling of 2-hydroxystyrenes and arylboronic acids, with Rh(III)-catalyst and Cu(OAc)2 as oxidant. The antiproliferative evaluation of all the synthesized compounds were assessed on four different human cancer cell lines (Colo-205, MDA-468, HT29, and MGC80-3), and the results showed that several compounds exhibit strong antiproliferative activities (up to IC50=35 nM for MGC80-3).
authors.affiliation: Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Mingyun
authors.initials: M
authors.lastname: Shen
authors.affiliation: Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: slcui@zju.edu.cn.
authors.forename: Sunliang
authors.initials: S
authors.lastname: Cui
authors.affiliation: Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: tingjunhou@zju.edu.cn.
authors.forename: Tingjun
authors.initials: T
authors.lastname: Hou
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D006900:Hydroxylation; D015394:Molecular Structure; D058451:Oxidative Coupling; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes
keywords: 2-Hydroxylated (E)-stilbenes; 2-Hydroxystyrenes; Antiproliferative; Arylboronic acids; Oxidative coupling