title: Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4.
abstract: Two substituted biaryl analogues of colchicine and combretastatin A4, readily available through a one-step, protecting group free Suzuki-Miyaura reaction were discovered to exhibit anticancer activity while simultaneously being of low cytotoxicity to noncancerous cell lines. The compounds were shown to initiate apoptosis selectively via a mechanism involving inhibition of tubulin polymerization.
authors.affiliation: Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ont. L8S 4M1, Canada.
authors.forename: James
authors.initials: J
authors.lastname: McNulty
authors.forename: Sean
authors.initials: S
authors.lastname: van den Berg
authors.forename: Dennis
authors.initials: D
authors.lastname: Ma
authors.forename: Daniel
authors.initials: D
authors.lastname: Tarade
authors.forename: Seema
authors.initials: S
authors.lastname: Joshi
authors.forename: Julia
authors.initials: J
authors.lastname: Church
mesh_terms: D050256:Antimitotic Agents / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045744:Cell Line, Tumor; D003078:Colchicine / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013267:Stilbenes / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D050256:Antimitotic Agents; D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C058728:fosbretabulin; D003078:Colchicine