title: The anti-catabolic role of bovine lactoferricin in cartilage.
abstract: Bovine lactoferricin (LfcinB) is a multifunctional peptide derived from bovine lactoferrin that demonstrates antibacterial, antifungal, antiviral, antitumor, and immunomodulatory activities. Recently, studies have focused on the anti-catabolic and anti-inflammatory potential of LfcinB. LfcinB is able to modulate the effects cytokines such as IL-1 and fibroblast growth factor 2 as well as promote specific cartilage anabolic factors. These properties are particularly important in maintaining cartilage homeostasis and preventing a catabolic state, which leads to clinical pathology. This review focuses on the recent literature elucidating the role of LfcinB in preventing cartilage degradation.
authors.forename: Kasra
authors.initials: K
authors.lastname: Ahmadinia
authors.forename: Dongyao
authors.initials: D
authors.lastname: Yan
authors.forename: Michael
authors.initials: M
authors.lastname: Ellman
authors.forename: Hee-Jeong
authors.initials: HJ
authors.lastname: Im
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002356:Cartilage / Q000187:drug effects* / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy; D007375:Interleukin-1 / Q000378:metabolism; D007403:Intervertebral Disc / Q000187:drug effects / Q000378:metabolism; D007781:Lactoferrin / Q000494:pharmacology* / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D007375:Interleukin-1; D016222:Fibroblast Growth Factor 2; C082171:lactoferricin B; D010450:Endopeptidases; D007781:Lactoferrin; D020782:Matrix Metalloproteinases