title: Bioactive thiazole and benzothiazole derivatives.
abstract: The heterocycles are the versatile compounds existing in almost all natural products and synthetic organic compounds, usually associated with one or the other biological activity. Among the heterocycles the thiazoles and benzothiazoles occupy a prominent position. They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thiamine, sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (antifungal drug) and tiazofurin (antineoplastic drug). The thiazole moiety is abundantly found in natural products while benzothiazole moiety is rare. In this review we disclose the literature reports of thiazoles and benzothiazoles possessing different biological activities.
authors.affiliation: Department of Chemistry, Middle East Technical University (METU), 06800 Ankara, Turkey.
authors.forename: Abdul
authors.initials: A
authors.lastname: Rouf
authors.affiliation: Department of Chemistry, Middle East Technical University (METU), 06800 Ankara, Turkey. Electronic address: tanyeli@metu.edu.tr.
authors.forename: Cihangir
authors.initials: C
authors.lastname: Tanyeli
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry* / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052160:Benzothiazoles; C005465:benzothiazole
keywords: Antibacterial activity; Anticancer activity; Benzothiazoles; Heterocycles; Thiazoles