title: SIRT1: role in cardiovascular biology.
abstract: SIRT1 (silent information regulator two protein) is a type III protein deacetylase that regulates a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance. It reverses cholesterol transport and reduces risk for development of atherosclerosis and cardiovascular disease. The following review highlights the potential role of SIRT1 on cardiovascular biology and function.
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China. Electronic address: liy_xw@sina.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D002319:Cardiovascular System / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology; D004734:Energy Metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D056564:Sirtuin 1 / Q000502:physiology*; D059506:Telomere Shortening
chemical_list: D002784:Cholesterol; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Cardiovascular biology; Expression regulation; SIRT1; Senescence