title: New approaches to psychiatric diagnostic classification.
abstract: Recent findings in psychiatric genetics have crystallized concerns that diagnostic categories used in the clinic map poorly onto the underlying biology. If we are to harness developments in genetics and neuroscience to understand disease mechanisms and develop new treatments, we need new approaches to patient stratification that recognize the complexity and continuous nature of psychiatric traits and that are not constrained by current categorical approaches. Recognizing this, the National Institute for Mental Health (NIMH) has developed a novel framework to encourage more research of this kind. The implications of these recent findings and funding policy developments for neuroscience research are considerable.
authors.affiliation: MRC Centre for Neuropsychiatric Genetics and Genomics, and the Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK. Electronic address: owenmj@cardiff.ac.uk.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D035843:Biomedical Research / Q000191:economics / Q000379:methods*; D005826:Genetics, Medical; D006801:Humans; D001523:Mental Disorders / Q000145:classification* / Q000175:diagnosis* / Q000191:economics / Q000235:genetics; D009488:Neurosciences / Q000379:methods; D015203:Reproducibility of Results