title: Risk of respiratory syncytial virus infection in infants with congenital cystic lung disease.
abstract: BACKGROUND
  Congenital cystic lung disease (CCLD), which includes congenital cystic adenomatoid malformation, bronchopulmonary sequestration, and congenital lobar emphysema, has been reported to increase the risk of recurrent respiratory infection. In particular, respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in high-risk infants. The objective of this study was to investigate the risk of severe RSV infection in infants with CCLD.
  
  
  METHODS
  Infants antenatally diagnosed as having CCLD and admitted to a neonatal intensive care unit at the National Center for Child Health and Development in Tokyo between September 2002 and October 2011 were included in this study. We investigated retrospectively whether the infants were hospitalized with RSV infection by 24 months of age using their medical records.
  
  
  RESULTS
  Forty-eight infants were antenatally diagnosed as having CCLD. Of the 48 infants, four (8.3%) were hospitalized with RSV infection by 24 months of age.
  
  
  CONCLUSIONS
  Infants with CCLD have increased risk of severe RSV infection.
authors.affiliation: Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Hama
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Tomoo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
mesh_terms: D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000175:diagnosis; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification*; D012189:Retrospective Studies; D012307:Risk Factors; D014041:Tokyo
keywords: bronchopulmonary sequestration; congenital cystic adenomatoid malformation; congenital lobar emphysema