title: [Association of mifepristone and misoprostol for the medical management of early pregnancy failure].
abstract: OBJECTIVE
  A retrospective monocentric clinical trial was performed to evaluate the efficacy of the association of mifepristone and misoprostol for the management of early pregnancy failure.
  
  
  METHODS
  Ninety-two women with early pregnancy failure or anembryonic pregnancy were first treated with 600 mg of mifepristone and 48 hours later with 400 μg of misoprostol by oral administration. Successful treatment, defined as an empty uterus, was searched at day 3, with the association of misoprostol-mifepristone alone or with complementary medical treatment, prostaglandins or ocytocine.
  
  
  RESULTS
  The overall treatment success was 82% (75 of 92 women) with 69 successful cases at day 3 (75%). Six of 92 women (7%) needed a second-line medical treatment. For the last 17 women (18%), the failure of the associated tested medical treatment lead to a secondary surgery. No prognostic factor for the successful medical treatment has been highlighted.
  
  
  CONCLUSIONS
  A high efficacy for the management of early pregnancy failure is demonstrated for the mifepristone and misoprostol medical treatment. The specific contribution of mifepristone, although proven in the cases of termination of evolutive pregnancies, should be further evaluated in the future for the specific management of early pregnancy failure. Nevertheless, no prognostic factor for the success of the propose treatment can be determined, as the amount of patients enrolled in this study was not sufficient.
authors.affiliation: Service de gynécologie obstétrique, maternité Bel-Air, CHR Metz-Thionville, 2, rue de friscaty, BP 60327, 57126 Thionville, France; Service de gynécologie obstétrique et médecine fœtale, pôle de la femme, maternité régionale universitaire de Nancy, université de Lorraine, 10, avenue Docteur Heydenreich, 54000 Nancy, France. Electronic address: laurianne.bouschbacher@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Bouschbacher
authors.affiliation: Service de gynécologie obstétrique, maternité Bel-Air, CHR Metz-Thionville, 2, rue de friscaty, BP 60327, 57126 Thionville, France.
authors.forename: A
authors.initials: A
authors.lastname: Maatouk
authors.affiliation: Service de gynécologie obstétrique, maternité Bel-Air, CHR Metz-Thionville, 2, rue de friscaty, BP 60327, 57126 Thionville, France.
authors.forename: P
authors.initials: P
authors.lastname: Collin
authors.affiliation: Service de gynécologie obstétrique, maternité Bel-Air, CHR Metz-Thionville, 2, rue de friscaty, BP 60327, 57126 Thionville, France.
authors.forename: E
authors.initials: E
authors.lastname: Welter
authors.affiliation: Service de gynécologie obstétrique et médecine fœtale, pôle de la femme, maternité régionale universitaire de Nancy, université de Lorraine, 10, avenue Docteur Heydenreich, 54000 Nancy, France.
authors.forename: O
authors.initials: O
authors.lastname: Morel
authors.affiliation: Service de gynécologie obstétrique et médecine fœtale, pôle de la femme, maternité régionale universitaire de Nancy, université de Lorraine, 10, avenue Docteur Heydenreich, 54000 Nancy, France.
authors.forename: C Mezan
authors.initials: CM
authors.lastname: de Malartic
mesh_terms: D000022:Abortion, Spontaneous / Q000188:drug therapy*; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005865:Gestational Age; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D010120:Oxytocics; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D015735:Mifepristone
keywords: Early pregnancy failure; Fausse couche; Medical treatment; Mifepristone; Mifépristone; Misoprostol; Traitement médical