title: Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.
abstract: Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
authors.affiliation: Department of Clinical Biology, Salah Azaiz Institut of Cancer, Tunis, Tunisia; INSERM, U940, Saint-Louis Hospital, Paris, France; Biochemistry Department, ISBAT, Science University of Tunis, Tunisia.
authors.forename: Arij
authors.initials: A
authors.lastname: Ben Chaaben
authors.forename: Christina
authors.initials: C
authors.lastname: Mariaselvam
authors.forename: Sofiane
authors.initials: S
authors.lastname: Salah
authors.forename: Marc
authors.initials: M
authors.lastname: Busson
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dulphy
authors.forename: Hayet
authors.initials: H
authors.lastname: Douik
authors.forename: Abderraouf
authors.initials: A
authors.lastname: Ghanem
authors.forename: Wahid
authors.initials: W
authors.lastname: Boukaouci
authors.forename: Reem
authors.initials: R
authors.lastname: Al Daccak
authors.forename: Tesnim
authors.initials: T
authors.lastname: Mamoghli
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.forename: Jihene
authors.initials: J
authors.lastname: Bouassida
authors.forename: Catherine
authors.initials: C
authors.lastname: Fortier
authors.forename: Said
authors.initials: S
authors.lastname: Gritli
authors.forename: Jeannette
authors.initials: J
authors.lastname: Ben Hamida
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
authors.forename: Ryad
authors.initials: R
authors.lastname: Tamouza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002277:Carcinoma; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D016017:Odds Ratio; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D005982:Glutathione Transferase