title: Could occupational physical activity mitigate the link between moderate kidney dysfunction and coronary heart disease?
abstract: BACKGROUND
  Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain.
  
  
  OBJECTIVE
  We aimed to identify the potential association of PA (occupational and leisure-time) on early decline of estimated glomerular filtration rate (eGFR) and to determine the potential mediating effect of PA on the relationship between eGFR and heart disease.
  
  
  METHODS
  From the PRIME study analyses were conducted in 1058 employed men. Energy expended during leisure, work and commuting was calculated. Linear regression analyses were used to determine the link between types of PA and moderate decrements of eGFR determined with the KDIGO guideline at the baseline assessment. Cox proportional hazards analyses were used to explore the potential effect of PA on the relationship between eGFR and heart disease, ascertained during follow-up over 10 years.
  
  
  RESULTS
  For these employed men, and after adjustment for known confounders of GFR change, more time spent sitting at work was associated with increased risk of moderate decline in kidney function, while carrying objects or being active at work was associated with decreased risk. In contrast, no significant link with leisure PA was apparent. No potential mediating effect of occupational PA was found for the relationship between eGFR and coronary heart disease.
  
  
  CONCLUSIONS
  Occupational PA (potential modifiable factors) could provide a dual role on early impairment of renal function, without influence on the relationship between early decrease of e-GFR and CHD risk.
authors.affiliation: Université Paul Sabatier de Toulouse III, UMR1027, Toulouse F-31073, France; CHU Toulouse, SMPE, Toulouse F-31059, France. Electronic address: Esquirol.y@chu-toulouse.fr.
authors.forename: Yolande
authors.initials: Y
authors.lastname: Esquirol
authors.affiliation: UK Clinical Research Collaboration Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Tully
authors.affiliation: Université Paul Sabatier de Toulouse III, UMR1027, Toulouse F-31073, France.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Ruidavets
authors.affiliation: Belfast Health and Social Care Trust, Belfast, UK.
authors.forename: Damian
authors.initials: D
authors.lastname: Fogarty
authors.affiliation: Université Paul Sabatier de Toulouse III, UMR1027, Toulouse F-31073, France; CHU Toulouse, Department of Cardiology B, Toulouse F-31059, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrieres
authors.affiliation: Belfast Health and Social Care Trust, Belfast, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Quinn
authors.affiliation: UK Clinical Research Collaboration Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Hughes
authors.affiliation: UK Clinical Research Collaboration Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK.
authors.forename: Frank
authors.initials: F
authors.lastname: Kee
mesh_terms: D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006801:Humans; D007899:Leisure Activities; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D016272:Occupational Health / Q000639:trends*; D009790:Occupations / Q000639:trends*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors
keywords: Exercise; Glomerular filtration rate; Work