title: Human Dobrava-Belgrade hantavirus infection, Kosovo.
abstract: Here we describe an acute Dobrava-Belgrade virus (DOBV) infection that presented as severe hemorrhagic fever with renal syndrome (HFRS) in an active-duty U.S. soldier. The infection was acquired in northern Kosovo in spring 2013. Amplification of DOBV genome segments directly from the patient's serum sample was successfully performed. Phylogenetic analysis demonstrated that the strain belong to DOBV genotype Dobrava and is closely related to strains circulating in Southeast Europe and Slovakia. Thus, our case confirms that DOBV genotype Dobrava is able to cause a severe form of HFRS, especially when compared to the other less pathogenic DOBV genotypes.
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Emmerich
authors.affiliation: Department of Internal Medicine, German Armed Forces Medical Centre, Hamburg, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Müller
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; Institute of Medical Virology, Charite Medical School, Berlin, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Heinemann
authors.affiliation: Department of Internal Medicine, German Armed Forces Medical Centre, Ulm, Germany.
authors.forename: Enno
authors.initials: E
authors.lastname: Rother
authors.affiliation: National Institute of Public Health of Kosovo, Pristina, Kosovo, Serbia.
authors.forename: Xhevat
authors.initials: X
authors.lastname: Jakupi
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Günther
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cadar
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; German Centre for Infection Research (DZIF), partner site Hamburg-Luebeck-Borstel, Hamburg, Germany. Electronic address: jonassi@gmx.de.
authors.forename: Jonas
authors.initials: J
authors.lastname: Schmidt-Chanasit
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D005838:Genotype; D006476:Orthohantavirus / Q000302:isolation & purification*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D063826:Kosovo; D008297:Male; D008889:Military Personnel; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral
keywords: Dobrava-Belgrade virus; Genome; HFRS; Hantavirus; Kosovo