title: P300 in individuals with sensorineural hearing loss.
abstract: BACKGROUND
  Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention.
  
  
  OBJECTIVE
  To study P300 in subjects with severe or profound sensorineural hearing loss.
  
  
  METHODS
  This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials.
  
  
  RESULTS
  A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97ms and mean amplitude of 3.76V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p=0.04), with the predominant auditory communication channels (p<0.0001), and with time of hearing loss.
  
  
  CONCLUSIONS
  P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome.
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FM-RP), Universidade de São Paulo (USP), São Paulo, SP, Brazil. Electronic address: anaclaudia@fmrp.usp.br.
authors.forename: Ana Cláudia Mirandola Barbosa
authors.initials: AC
authors.lastname: Reis
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil.
authors.forename: Ana Claudia Figueiredo
authors.initials: AC
authors.lastname: Frizzo
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FM-RP), Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Myriam de Lima
authors.initials: Mde L
authors.lastname: Isaac
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Cristiane Fregonesi Dutra
authors.initials: CF
authors.lastname: Garcia
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FM-RP), Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Carolina Araújo Rodrigues
authors.initials: CA
authors.lastname: Funayama
authors.affiliation: Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Maria Cecília Martinelli
authors.initials: MC
authors.lastname: Iório
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D003430:Cross-Sectional Studies; D004594:Electrophysiology; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013069:Speech Reception Threshold Test; D055815:Young Adult
keywords: Auditory cortex; Auditory evoked potentials; Córtex auditivo; Electrophysiology; Eletrofisiologia; Event-related potentials, P300; Hearing loss; Perda auditiva; Potenciais evocados auditivos; Potencial evocado P300