title: Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update.
abstract: OBJECTIVE
  Treatment outcomes were analyzed for patients who received radiotherapy for squamous cell carcinoma of the retromolar trigone at a single institution.
  
  
  METHODS
  We reviewed the medical records of 110 patients treated with radiotherapy alone (n=36) or radiotherapy combined with surgical resection of the primary tumor (n=74) between June 1966 and October 2013. The median follow-up was 4.5years for all patients and 11.8years for living patients (range, 1.3-23.5years).
  
  
  RESULTS
  The 5-year local-regional control rates after definitive radiotherapy versus surgery and radiotherapy for stages I-III were 52% and 89% and for stage IV they were 46% and 58%, respectively. The 5-year cause-specific survival rates after definitive radiotherapy compared with surgery and radiotherapy for stages I-III were 57% and 82% and for stage IV they were 45% and 43%, respectively. Multivariate analyses revealed that the likelihood of cure was better with surgery and radiotherapy compared with radiotherapy alone (p=0.041).
  
  
  CONCLUSIONS
  Patients treated with surgery and radiotherapy had a better chance of cure than those treated with radiotherapy alone. Complications of treatment were common in both groups but more common in patients who underwent surgery.
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Hitchcock
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.affiliation: Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Werning
authors.affiliation: Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Dziegielewski
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: mendwm@shands.ufl.edu.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000473:pathology / Q000601:surgery; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome