title: Giant Cell Tumors of the Foot and Ankle Bones: High Recurrence Rates After Surgical Treatment.
abstract: Giant cell tumor (GCT) of the bone is a benign primary bone tumor most often treated with intralesional surgery. Most cases occur around the knee; however, rarely, GCT of bone can occur in the foot and ankle. Limited data exist about the outcomes after treatment of GCT in this location. We retrospectively reviewed an orthopedic oncology database from 1970 to 2010 for cases of GCT of the bone, specifically within the foot and ankle bones. After exclusionary criteria were applied, a total of 19 disease sites in 18 patients were included for analysis. Of the 19 disease sites, 10 recurred. Patients, on average, required 1.7 operations per disease site. Of the 18 patients, 10 required ≥2 operations, 3 required ≥3 operations, and 1 required 4 operations. A total of 4 amputations were performed, including 2 below the knee amputations. Of the 10 patients with recurrence, 2 also had evidence of metastatic disease. The recurrence rates of GCT in the foot and ankle bones appear to be greatest after intralesional curettage without the use of cement. Although the recurrence rates are high, intralesional operations with multiple adjuvant therapy can eventually result in cure.
authors.affiliation: Assistant Professor, Department of Orthopaedics, University of Texas Health Sciences Center San Antonio, San Antonio, TX. Electronic address: Rajani@uthscsa.edu.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Rajani
authors.affiliation: Resident, Department of Orthopaedics, University of Texas Health Sciences Center San Antonio, San Antonio, TX.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Schaefer
authors.affiliation: Professor, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Scarborough
authors.affiliation: Professor, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL.
authors.forename: C Parker
authors.initials: CP
authors.lastname: Gibbs
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000601:surgery*; D005260:Female; D005528:Foot / Q000601:surgery*; D018212:Giant Cell Tumor of Bone / Q000601:surgery*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D013639:Tarsal Bones / Q000601:surgery*
keywords: amputation; benign bone tumors; giant cell tumor of bone; incidence; metastatic disease; tumor recurrence