title: Inflammation versus host defense in obesity.
abstract: Obesity is characterized by a state of low-grade, chronic inflammation. Wang et al. (2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hwu@bcm.edu.
authors.forename: Huaizhu
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D018928:Immunity, Mucosal; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism*
chemical_list: D007378:Interleukins