title: Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis.
abstract: OBJECTIVE
  To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  A patient who presented with a painful peripheral corneal infiltrate underwent PACK-CXL with a local limited abrasion and accelerated ultraviolet-A irradiation at 365 μm and 9 mW/cm² for 10 minutes. Cultures grew Aureobasidium pullulans. The corneal epithelium closed completely within 3 days and the infiltrate was completely eradicated without administration of antibiotics.
  
  
  CONCLUSIONS
  Accelerated PACK-CXL was successfully used as a first-line and sole treatment in a case of early fungal keratitis caused by Aureobasidium pullulans. Further characterization of the antifungal effect of PACK-CXL is needed in prospective studies.
authors.forename: David
authors.initials: D
authors.lastname: Tabibian
authors.forename: Olivier
authors.initials: O
authors.lastname: Richoz
authors.forename: Arnaud
authors.initials: A
authors.lastname: Riat
authors.forename: Jacques
authors.initials: J
authors.lastname: Schrenzel
authors.forename: Farhad
authors.initials: F
authors.lastname: Hafezi
mesh_terms: D000328:Adult; D001203:Ascomycota / Q000302:isolation & purification*; D003094:Collagen / Q000378:metabolism*; D003319:Corneal Stroma / Q000378:metabolism*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D003432:Cross-Linking Reagents / Q000627:therapeutic use; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012256:Riboflavin / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin