title: Recurrent, spontaneous esophageal ruptures associated with antiphospholipid antibody syndrome: report of a case.
abstract: A 52-year-old man was admitted to our hospital with a spontaneous esophageal rupture (Boerhaave syndrome) and was successfully treated. Eight years after the first incident, he was readmitted with a recurrent rupture. Recurrence of Boerhaave syndrome is extremely rare, with only 7 cases reported in the English literature. During treatment, the patient was also diagnosed with antiphospholipid syndrome (APS). Although APS is known to cause a variety of symptoms due to vascular thrombosis, recurrence of Boerhaave syndrome, coincident with APS, has never been reported. The pathogenesis of Boerhaave syndrome has not been clearly determined. This report serves to increase awareness of the risk of APS, which results in an increased risk of spontaneous rupture of the esophagus.
authors.affiliation: 1 Department of Surgery, Social Insurance Gunma Chuo General Hospital, Maebashi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naitoh
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kiriyama
authors.forename: Takaharu
authors.initials: T
authors.lastname: Fukasawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tabe
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kana
authors.initials: K
authors.lastname: Saito
authors.forename: Kei
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004939:Esophageal Perforation / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D004945:Esophagoscopy; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D008875:Middle Aged; D012008:Recurrence; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed; D004935:Esophageal Diseases; D000072663:Spontaneous Perforation
keywords: Antiphospholipid syndrome; Boerhaave syndrome; Esophageal rupture