title: Pseudomonas aeruginosa in CF and non-CF homes is found predominantly in drains.
abstract: BACKGROUND
  For patients with cystic fibrosis (CF) Pseudomonas aeruginosa infection is a major contributor to progressive lung disease. While colonizing strains are thought to be primarily environmental, which environments are important in lung colonization is unclear.
  
  
  METHODS
  We took 11,674 samples from a broad range of sites over 3-8 visits to homes with (7) and without (8) CF patients.
  
  
  RESULTS
  Twenty-eight percent of sampled drains yielded P. aeruginosa at least once, and a general mixed linear model estimated that 6.3% of samples from drains yield P. aeruginosa. This is more than eight times the estimated recovery from any other type of household environment.
  
  
  CONCLUSIONS
  These findings implicate drains as important potential sources of P. aeruginosa infection. They suggest that maximizing P. aeruginosa control efforts for drains would reduce exposure with minimal extra burden to CF patients and families.
authors.affiliation: University of Louisville, Dept. of Biology, Louisville, KY 40292, United States.
authors.forename: M E
authors.initials: ME
authors.lastname: Purdy-Gibson
authors.affiliation: University of Idaho, Dept. of Biological Sciences and Institute for Bioinformatics and Evolutionary Studies, Moscow, ID 83844, United States.
authors.forename: M
authors.initials: M
authors.lastname: France
authors.affiliation: University of Louisville, Dept. of Biology, Louisville, KY 40292, United States.
authors.forename: T C
authors.initials: TC
authors.lastname: Hundley
authors.affiliation: University of Louisville Medical School, Dept. of Pediatric Pulmonology, Louisville, KY 40292, United States.
authors.forename: N
authors.initials: N
authors.lastname: Eid
authors.affiliation: University of Louisville, Dept. of Biology, Louisville, KY 40292, United States. Electronic address: susanna.remold@louisville.edu.
authors.forename: S K
authors.initials: SK
authors.lastname: Remold
mesh_terms: D003550:Cystic Fibrosis / Q000453:epidemiology / Q000382:microbiology*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000382:microbiology*; D008297:Male; D009017:Morbidity / Q000639:trends; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012189:Retrospective Studies; D012722:Sewage / Q000382:microbiology*; D014481:United States / Q000453:epidemiology
chemical_list: D012722:Sewage
keywords: Cystic fibrosis; Environmental source; Household drains; Human home; Pseudomonas aeruginosa