title: Palladium(0)-catalyzed single and double isonitrile insertion: a facile synthesis of benzofurans, indoles, and isatins.
abstract: A palladium(0)-catalyzed cascade process consisting of isonitrile insertion and α-Csp(3)-H cross-coupling can be achieved for the synthesis of benzofurans and indoles. The construction of isatins by a Pd-catalyzed cascade reaction incorporating double isonitrile insertion, amination, and hydrolysis has also been achieved. The key features of this work include diverse heterocycle synthesis, phosphine-ligand-free reaction conditions, a one-pot procedure, simple and commercially available starting materials, broad functional-group compatibility, and moderate to good reaction yields.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan 1 st Rd, Sanmin district, Kaohsiung City, 807 (Taiwan).
authors.forename: Gopal Chandru
authors.initials: GC
authors.lastname: Senadi
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Siva Senthil Kumar
authors.initials: SS
authors.lastname: Boominathan
authors.forename: Jeh-Jeng
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000586:Amination; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006868:Hydrolysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007510:Isatin / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D007211:Indoles; D009570:Nitriles; D010165:Palladium; D007510:Isatin
keywords: benzofurans; indoles; insertion; isatins; palladium