title: Pre-exposure prophylaxis for human immunodeficiency virus: the past, present, and future.
abstract: This article presents an overview of pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) prevention. The authors describe the past animal and human research that has been conducted that informs our current understanding of PrEP; summarize ongoing research in the area, including describing new regimens and delivery mechanisms being studied for PrEP; and highlight key issues that must be addressed in order to implement and optimize the use of this HIV prevention tool.
authors.affiliation: Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue, Northwest, 5th Floor, Washington, DC 20052, USA. Electronic address: acastel@gwu.edu.
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Castel
authors.affiliation: Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue, Northwest, 5th Floor, Washington, DC 20052, USA.
authors.forename: Manya
authors.initials: M
authors.lastname: Magnus
authors.affiliation: Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue, Northwest, 5th Floor, Washington, DC 20052, USA.
authors.forename: Alan E
authors.initials: AE
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005544:Forecasting; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D065129:Pre-Exposure Prophylaxis / Q000639:trends
chemical_list: D019380:Anti-HIV Agents
keywords: Adherence; Biomedical intervention; HIV prevention; Implementation; Pre-exposure prophylaxis