title: Increased serum mannose binding lectin levels are associated with diabetic retinopathy.
abstract: BACKGROUND
  Mannose-binding lectin (MBL) may be implicated in the pathogenesis of diabetic retinopathy (DR) complications. We investigated serum MBL levels in type 2 diabetic patients with and without DR.
  
  
  METHODS
  Serum MBL levels were determined in 184 type 2 diabetic patients with DR and 189 type 2 diabetic patients without DR matched for age, sex, and duration of diabetes. Multivariate analyses were performed using logistic regression models. The diagnostic value of MBL was compared with the HbA1c, Hs-CRP and with other known markers.
  
  
  RESULTS
  We found that serum MBL levels were significantly higher in diabetes with DR as compared to without-DR [3456 (IQR, 3128-3800) ug/l and 2432 (IQR, 2100-2670) ug/l, respectively; P<0.0001]. In multivariate logistic regression analysis, after adjusting for all other significant factors, MBL remained can be seen as an independent DR marker with an adjusted OR of 1.002 (95% CI, 1.001-1.003; P<0.0001). Based on the ROC curve, the optimal cutoff value of serum MBL levels as an indicator for diagnosis of DR was projected to be 3050 ug/L, which yielded a sensitivity of 82.5% and a specificity of 88.0%, with the area under the curve at 0.907 (95% CI, 0.876-0.938).
  
  
  CONCLUSIONS
  In type 2 diabetic patients, evaluated serum levels of MBL can be seen as an independent marker of DR even after correcting for possible confounding factors.
authors.affiliation: Department of Ophthalmology, Yantai Yuhuangding Hospital, Yantai, China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Man
authors.affiliation: Shanghai Tian tan pu hua Hospital, Shanghai, China.
authors.forename: Houliang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Yantai Yuhuangding Hospital, Yantai, China.
authors.forename: Huajun
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology, Yantai Yuhuangding Hospital, Yantai, China.
authors.forename: Lusheng
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Laboratory, Yantai Yuhuangding Hospital, Yantai, China. Electronic address: duqqj535@163.com.
authors.forename: Jiangdong
authors.initials: J
authors.lastname: Du
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D016001:Confidence Intervals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D037601:Mannose-Binding Lectin
keywords: Chinese; Diabetic retinopathy; Mannose-binding lectin; Risk; Type 2 diabetic patients