title: A novel treatment target for Parkinson's disease.
abstract: We hypothesize that GPR109A message and expression are up-regulated in individuals with Parkinson's disease (PD). GPR109A is a high-affinity niacin receptor. Niacin is a precursor for NAD-NADH which is needed for dopamine production. Thus, niacin supplementation may serve three purposes: reduce inflammation through GPR109A-related mechanisms, increase dopamine synthesis in the striatum through NADPH supply and increase NAD/NADH ratio to boost mitochondrial functions. GPR109A and its agonists are known to exert anti-inflammatory actions in the skin, gut and retina. However these roles are neither anticipated nor established in the CNS. For the first time here we propose the roles of GPR109A and its agonists including niacin in CNS pathology. Moreover we predict that the neuroprotective roles of either niacin or butyrates in CNS occur via GPR109A.
authors.affiliation: Department of Physical Therapy, Georgia Regents University, Augusta, GA, USA. Electronic address: cwakade@gru.edu.
authors.forename: Chandramohan
authors.initials: C
authors.lastname: Wakade
authors.affiliation: Department of Physical Therapy, Georgia Regents University, Augusta, GA, USA. Electronic address: rchong@gru.edu.
authors.forename: Raymond
authors.initials: R
authors.lastname: Chong
mesh_terms: D000368:Aged; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D009525:Niacin / Q000378:metabolism / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C530636:HCAR2 protein, human; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D043562:Receptors, G-Protein-Coupled; D011978:Receptors, Nicotinic; D009243:NAD; D009525:Niacin; D004298:Dopamine
keywords: GPR109A; HCAR2; HM74a; Inflammation; Niacin; Niacinamide