title: [Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia].
abstract: OBJECTIVE
  Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy.
  
  
  METHODS
  45 patients between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into three groups on the way to surgery: propofol (group P, n=15), sevoflurane (group S, n=15) and desflurane (group D, n=15). All groups were given hypnotic 2mg/kg propofol IV, 1mcg/kg fentanyl IV and 0.1mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, group D cases were given 6% desflurane and group P were given propofol infusions of 12mg/kg/h for the first 10minutes, 9mg/kg/h for the second 10minutes and 6mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants.
  
  
  CONCLUSIONS
  The 45 patients included in the study were 22 male and 23 female patients. The demographic characteristics of the groups were similar. In the postoperative period we observed that while sevoflurane and propofol increased antioxidants by a statistically significant level, desflurane increased the total oxidants level by a significant amount compared to levels before the operation.
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina, Çanakkale Onsekiz Mart University, Canakkale, Turquia.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbas
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina, Duzce University, Duzce, Turquia. Electronic address: demiraran@gmail.com.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Demiraran
authors.affiliation: Departamento de Bioquímica, Hospital Mehmet Akif Ersoy de Pesquisa e Formação em Cirurgia Torácica e Cardiovascular, Istambul, Turquia.
authors.forename: Hayriye Ak
authors.initials: HA
authors.lastname: Yildirim
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina, Duzce University, Duzce, Turquia.
authors.forename: Gulbin
authors.initials: G
authors.lastname: Sezen
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina, Duzce University, Duzce, Turquia.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Iskender
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina, Duzce University, Duzce, Turquia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Karagoz
authors.affiliation: Departamento de Medicina de Emergência, Faculdade de Medicina, Duzce University, Duzce, Turquia.
authors.forename: Hayati
authors.initials: H
authors.lastname: Kandis
keywords: Anestesia geral; Antioxidant; Antioxidante; General anesthesia; Oxidant; Oxidante; Propofol