title: One-step preparation of hydrophilic carbon nanofiber containing magnetic Ni nanoparticles materials and their application in drug delivery.
abstract: A one-step process for the synthesis of hydrophilic carbon nanofibers (CNFs) through CO2 hydrogenation on NiNa/Al2O3 was developed for the loading and targeted delivery of the anticancer drug doxorubicin (DOX). CNFs that were synthesized on NiNa/Al2O3 for 9 h at 500 °C exhibited an adequate magnetic response and a large content of hydrophilic oxygen-containing functional groups on the carbon surface, resulting in excellent colloidal solution. The CNF material exhibited a highly efficient capacity for DOX adsorption, particularly at pH 9.0. The loading and release of DOX was strongly pH dependent, possibly due to electrostatic and π-π stacking interactions between DOX and CNF sample. The Langmuir isotherm and pseudo second-order kinetics of DOX-loaded CNFs were well-modeled for the process of DOX adsorption. DOX-loaded CNF targeted cancer cells more selectively and effectively than free DOX and exhibited a marked tendency to kill HeLa cancer cells and reduced toxicity to normal human primary fibroblast (HPF) cells.
authors.affiliation: Center for General Education, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: scottpw@hotmail.com.
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital, 5, Fusing St., Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: ctc323@adm.cgmh.org.tw.
authors.forename: Tse-Ching
authors.initials: TC
authors.lastname: Chen
authors.affiliation: Department of Materials Science, National University of Tainan, 33, Sec. 2, Shu-Lin St., Tainan 700, Taiwan, ROC. Electronic address: janusjhlin@mail.nutn.edu.tw.
authors.forename: Jarrn-Horng
authors.initials: JH
authors.lastname: Lin
authors.affiliation: Department of Molecular and Cellular Biology, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: d9201110@stmail.cgu.edu.tw.
authors.forename: Pei-Rong
authors.initials: PR
authors.lastname: Huang
authors.affiliation: Center for General Education, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: rachealjui@hotmail.com.
authors.forename: Hsing-Jui
authors.initials: HJ
authors.lastname: Tsai
authors.affiliation: Center for General Education, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: cschen@mail.cgu.edu.tw.
authors.forename: Ching-Shiun
authors.initials: CS
authors.lastname: Chen
mesh_terms: D002244:Carbon / Q000737:chemistry*; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D002244:Carbon; D009532:Nickel
keywords: CO(2) hydrogenation; Carbon nanofibers; Doxorubicin; Drug delivery; Magnetic Ni