title: Copper-catalyzed/promoted cross-coupling of gem-diborylalkanes with nonactivated primary alkyl halides: an alternative route to alkylboronic esters.
abstract: The first copper-catalyzed/promoted sp(3)-C Suzuki-Miyaura coupling reaction of gem-diborylalkanes with nonactivated electrophilic reagents is reported. Not only 1, 1-diborylalkanes but also some other gem-diborylalkanes can be coupled with nonactivated primary alkyl halides, offering a new method for sp(3)C-sp(3)C bond formation and, simultaneously, providing a new strategy for the synthesis of alkylboronic esters.
authors.affiliation: Anhui Province Key Laboratory of Biomass Clean Energy Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Zhen-Qi
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Chu-Ting
authors.initials: CT
authors.lastname: Yang
authors.forename: Lu-Jun
authors.initials: LJ
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Liu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Sun
authors.forename: Todd B
authors.initials: TB
authors.lastname: Marder
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004952:Esters; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001896:Boron Compounds; D003432:Cross-Linking Reagents; D004952:Esters; D006846:Hydrocarbons, Halogenated; D003300:Copper