title: Supermacroporous polymer monolith prepared with polymeric porogens via viscoelastic phase separation for capillary electrochromatography.
abstract: Supermacroporous poly(methacrylic acid-butyl methacrylate-ethylene glycol dimethacrylate) monoliths with the pore size up to 5-10 μm were successfully prepared in a ternary polymeric porogens utilizing viscoelastic effect. High concentration (over 20 mg/mL) of polystyrene (PS) in porogen was used to achieve the desirable characteristics of the monolithic capillary. Modification of the co-porogen composition, i.e., the content of dimethyl sulfoxide and isooctane, enabled tailoring of the supermacropore structure with a wide range of pore size. The effects of the amount of polymer porogen and molecular weights of PS on the formation of supermacropore were also studied. In preliminary applications, the separations of alkyl phenones and alkylbenzenes were achieved on the supermacropore columns using a mode of capillary electrochromatography. The study demonstrated successfully the ability of polymer porogen to form supermacropore monolith via viscoelastic phase separation.
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Shang
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Pang
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Li-Shun
authors.initials: LS
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Huang
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address: zhaoshengliu@sohu.com.
authors.forename: Zhao-Sheng
authors.initials: ZS
authors.lastname: Liu
mesh_terms: D053801:Capillary Electrochromatography / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004548:Elasticity; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results; D014783:Viscosity
chemical_list: D011109:Polymethacrylic Acids; C000597207:poly(methacrylic acid-butyl methacrylate-ethylene glycol dimethacrylate); D011092:Polyethylene Glycols
keywords: Capillary electrochromatography; Monolithic columns; Polymeric porogens; Polystyrene; Supermacroporous polymer