title: Impaired gallbladder motility in adults with newly detected type 2 diabetes and lack of reversibility after achieving euglycemia.
abstract: OBJECTIVE
  The effects of hyperglycemia and normoglycemia on gallbladder emptying have not been studied in detail. This prospective case-control study was designed to investigate the gallbladder ejection fraction in patients with newly detected diabetes and to assess the impact of restoring normoglycemia on gallbladder ejection fraction in such patients.
  
  
  METHODS
  (99m)Tc-mebrofenin scintigraphy was performed in 22 patients with newly detected type 2 diabetes for measurement of gallbladder ejection fraction. The scintigraphy was performed at the time of first presentation and again 6 months after control of diabetes (glycated hemoglobin [A1C] <7%). Also, gallbladder ejection fraction was measured in 20 age- and sex-matched controls without diabetes.
  
  
  RESULTS
  Gallbladder ejection fraction was lower in patients with newly detected diabetes compared with controls (31.4%±5.9% vs. 70.7%±4.3%, p<0.001). Gallbladder ejection fraction did not improve after the treatment of diabetes mellitus (21.3%±5.7%, p=0.395).
  
  
  CONCLUSIONS
  Gallbladder ejection fraction was markedly reduced in patients with newly detected diabetes compared to controls without diabetes. Control of diabetes and normalization of A1C did not reverse the motility defect.
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Faheem
authors.initials: F
authors.lastname: Arshad
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India. Electronic address: drlaway@gmail.com.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.affiliation: Department of Nuclear Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Tanveer Ahmad
authors.initials: TA
authors.lastname: Rather
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Mohammad Shafi
authors.initials: MS
authors.lastname: Kuchay
authors.affiliation: Department of Nuclear Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Shoukat Hussain
authors.initials: SH
authors.lastname: Khan
mesh_terms: D000328:Adult; D000814:Aniline Compounds; D001786:Blood Glucose / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016473:Gallbladder Emptying / Q000502:physiology*; D005998:Glycine; D006801:Humans; D007098:Imino Acids; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging
chemical_list: D000814:Aniline Compounds; D001786:Blood Glucose; D007098:Imino Acids; D015609:Organotechnetium Compounds; C034837:technetium Tc 99m mebrofenin; D005998:Glycine
keywords: (99m)TC-mebrofenin scintigraphy; diabetes; diabète; fraction d’éjection de la vésicule biliaire; gallbladder ejection fraction; scintigraphie après injection de mébrofénine-technétium 99m ((99m) Tc)