title: A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea.
abstract: This work presents a methodology for the in vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the deformation of human corneas due to non-contact tonometry, and an iterative search controlled by a genetic heuristic was used to estimate the elastic parameters that most closely approximates the simulated deformation to the real one. The results from a synthetic experiment showed that these parameters can be estimated with an error of about 5%. The results of 24 in vivo corneas showed an overlap of about 90% between simulation and real deformed cornea and a modified Hausdorff distance of 25 μm, which indicates the great accuracy of the proposed methodology.
authors.affiliation: LabHuman, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address: malago@labhuman.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Lago
authors.affiliation: LabHuman, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rupérez
authors.affiliation: LabHuman, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Martínez
authors.affiliation: LabHuman, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Monserrat
authors.affiliation: AJL Ophthalmics, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Larra
authors.affiliation: Instituto de Microcirugía Ocular, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Güell
authors.affiliation: Fundación Oftalmológica del Mediterráneo, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Peris-Martínez
mesh_terms: D000328:Adult; D000465:Algorithms; D001696:Biomechanical Phenomena / Q000502:physiology; D003315:Cornea / Q000502:physiology*; D004548:Elasticity / Q000502:physiology*; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008954:Models, Biological; D066230:Patient-Specific Modeling; D014065:Tonometry, Ocular
keywords: Biomechanical characterization; Cornea; Parameter optimization