title: Biomarkers and physiopathology in the cardiorenal syndrome.
abstract: Acute cardiorenal syndrome (CRS) corresponds to an association of acute heart failure and a worsening of renal function. The detection of acute kidney injury (AKI) unfortunately occurs at a late stage of CRS, leading to an increased mortality of the patients. In this review, we described the pathophysiology of CRS and discussed the potential interest of biochemical biomarkers (namely creatinine, cystatin C, NGAL, KIM-1, fatty acid binding protein, Nacetyl-β-D-glucosaminidase and IL-18) that could potentially help to detect AKI earlier and thus reduce the morbi-mortality of the patients suffering from CRS.
authors.affiliation: Department of Nephrology, Dialysis, Transplantation, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium. Electronic address: antoine.bouquegneau@chu.ulg.ac.be.
authors.forename: Antoine
authors.initials: A
authors.lastname: Bouquegneau
authors.affiliation: Department of Nephrology, Dialysis, Transplantation, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.affiliation: Department of Nephrology, Dialysis, Transplantation, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.affiliation: Department of Biochemistry, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D059347:Cardio-Renal Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: Acute kidney injury; Cardiorenal syndrome; Creatinine; Cystatine; Kidney failure; NGAL