title: Assessment of coronary hemodynamics and vascular function.
abstract: Coronary blood flow closely matches to metabolic demands of heart and myocardial oxygen consumption and is conditioned by function of coronary resistance vessels. The microvascular endothelium of coronary resistance vessels is exposed to a spatially and temporally regulated input from cardiomyocytes and the haemodynamic forces of the cardiac cycle. Functional measurements of coronary pressure and flow are important approaches that provide complementary information on the function of coronary vessel function that could not be assessed by the methods utilized for the anatomic characterization of coronary disease, such as coronary angiography. The goal of this paper is to review the methodologies for assessment of coronary vascular function and haemodynamics which are utilized in research and to discuss their potential applicability in the clinical settings.
authors.affiliation: Faculty of Medicine Osijek, University of Osijek, Department of Physiology and Immunology, Osijek, Croatia. Electronic address: ines.drenjancevic@mefos.hr.
authors.forename: Ines
authors.initials: I
authors.lastname: Drenjancevic
authors.affiliation: Department of Physiology and Gerontology, Medical School and Szentagothai Research Centre, University of Pecs, Hungary, Department of Pathophysiology, Semmelweis University, Budapest, Hungary, Department of Physiology New York Medical College, Valhalla NY 10595, USA; Walhala University NW, USA.
authors.forename: Akos
authors.initials: A
authors.lastname: Koller
authors.affiliation: Faculty of Medicine Osijek, University of Osijek, Dept of Internal Medicine, Osijek, Croatia; Clinical Hospital Center Osijek, Clinic for Internal Diseases, Osijek, Croatia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Selthofer-Relatic
authors.affiliation: Faculty of Medicine Osijek, University of Osijek, Department of Physiology and Immunology, Osijek, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Grizelj
authors.affiliation: Faculty of Medicine Osijek, University of Osijek, Department of Physiology and Immunology, Osijek, Croatia.
authors.forename: Ana
authors.initials: A
authors.lastname: Cavka
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism / Q000503:physiopathology*; D003935:Diagnostic Techniques, Cardiovascular; D006439:Hemodynamics; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Coronarography; Coronary blood flow; Coronary pressure; Coronary resistance vessels