title: The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease.
abstract: We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed with multicentric CD, a non-malignant lymphoproliferative disorder fueled by excessive IL-6 production. Treatment with IL-6 blockade (tocilizumab) every two wk and methylprednisolone had no effect on his lymph nodes or cardiac function while on temporary RotaFlow. A Berlin LVAD was placed for treatment with rituximab, COP, vincristine, and methylprednisolone. After three courses of chemotherapy, his inflammatory markers normalized and his lymphadenopathy decreased but cardiac function remained severely depressed. He tolerated chemotherapy on the Berlin but required frequent titrations of his anti-coagulation regimen and he did suffer a hemorrhagic stroke. His clinical status improved significantly with rehabilitation, and he tolerated heart transplantation without further complications. MCS is a feasible option as a bridge to recovery or heart transplant eligibility for patients with hemodynamic collapse requiring chemotherapy but it does necessitate close titration of the anti-coagulation regimen to coincide with changes in the inflammatory state.
authors.affiliation: The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Tamara O
authors.initials: TO
authors.lastname: Thomas
authors.forename: Shanmuganathan
authors.initials: S
authors.lastname: Chandrakasan
authors.forename: Maureen
authors.initials: M
authors.lastname: O'Brien
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Ryan
authors.forename: Ivan
authors.initials: I
authors.lastname: Wilmot
authors.forename: Michael L
authors.initials: ML
authors.lastname: Baker
authors.forename: Peace C
authors.initials: PC
authors.lastname: Madueme
authors.forename: David
authors.initials: D
authors.lastname: Morales
authors.forename: Angela
authors.initials: A
authors.lastname: Lorts
mesh_terms: D002313:Cardiomyopathy, Restrictive / Q000150:complications / Q000601:surgery*; D005871:Castleman Disease / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male
keywords: Castleman's disease; cardiac function; cardiomyopathy; lymphoproliferative disorder; mechanical circulatory; pediatric heart transplant; support