title: Erythrocyte sedimentation rate as baseline predictor for the development of uveitis in children with juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis.
  
  
  RESULTS
  One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed.
  
  
  CONCLUSIONS
  Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
authors.affiliation: Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands. Electronic address: a.j.w.haasnoot@umcutrecht.nl.
authors.forename: Arenda J W
authors.initials: AJ
authors.lastname: Haasnoot
authors.affiliation: Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands.
authors.forename: Maretta
authors.initials: M
authors.lastname: van Tent-Hoeve
authors.affiliation: Department of Pediatric Rheumatology, Utrecht University Medical Center, Wilhelmina Children's Hospital, Utrecht, Netherlands.
authors.forename: Nico M
authors.initials: NM
authors.lastname: Wulffraat
authors.affiliation: Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.
authors.forename: Nicoline E
authors.initials: NE
authors.lastname: Schalij-Delfos
authors.affiliation: Department of Ophthalmology, Groningen University Medical Center, Groningen, Netherlands.
authors.forename: Leonoor I
authors.initials: LI
authors.lastname: Los
authors.affiliation: Department of Pediatric Rheumatology, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, Netherlands.
authors.forename: Wineke
authors.initials: W
authors.lastname: Armbrust
authors.affiliation: Department of Biostatistics and Research Support, Julius Center, Utrecht University Medical Center, Utrecht, Netherlands.
authors.forename: Nicolaas P A
authors.initials: NP
authors.lastname: Zuithoff
authors.affiliation: Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands.
authors.forename: Joke H
authors.initials: JH
authors.lastname: de Boer
mesh_terms: D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000097:blood; D001171:Arthritis, Juvenile / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D012189:Retrospective Studies; D014605:Uveitis / Q000097:blood*
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; D015796:HLA-B27 Antigen; D002097:C-Reactive Protein