title: Individual risk stratification of gastric cancer: evolving concepts and their impact on clinical practice.
abstract: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide and it mostly develops in long-standing inflammatory conditions, and Helicobacter pylori-gastritis, in particular. Despite the increasing understanding of both the phenotypic alterations and the molecular mechanisms occurring during GC multi-step carcinogenesis, no reliable biomarker is available to be reliably implemented into GC secondary prevention strategies. Multidisciplinary diagnostic approaches integrating endoscopy, serology, histology and molecular profiling currently appears as the most appropriate approach for patients' stratification into different GC risk classes.
authors.affiliation: Department of Medicine, DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, 35100 Padua, Italy. Electronic address: massimo.rugge@unipd.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
authors.forename: Lisette G
authors.initials: LG
authors.lastname: Capelle
authors.affiliation: Department of Medicine, DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, 35100 Padua, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Fassan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000382:microbiology; D015415:Biomarkers / Q000378:metabolism; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000473:pathology*; D006801:Humans; D011230:Precancerous Conditions / Q000473:pathology; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000382:microbiology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Gastric cancer; Gastritis; Gastritis staging; Molecular pathology; OLGA; OLGIM