title: Alterations of natural killer cells in traumatic brain injury.
abstract: To investigate the relationship between natural killer (NK) cells and traumatic brain injury (TBI), we tracked an established phenotype of circulating NK cells at several time points in patients with different grades of TBI. In serial peripheral blood samples, NK cells were prospectively measured by flow cytometry of CD3(-) CD56(+) lymphocytes. Compared to healthy controls, TBI patients had reductions in both the percentage and the absolute number of NK cells. Furthermore, the magnitude of NK cell reduction correlated with the degree of TBI severity at several time points. That is, NK cell population size was independently associated with lower Glasgow Coma Scale scores. In addition, at some time points, a positive correlation was found between the NK cell counts and Glasgow Outcome Scale scores. Our results indicate that TBI induces a reduction in the number of NK cells, and the magnitude of the reduction appears to parallel the severity of TBI.
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.|Department of Geriatrics, Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Kong
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Bai
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Hui-Jie
authors.initials: HJ
authors.lastname: Wei
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Jin
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Li
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. fshi@tijmu.edu.cn.|Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. fshi@tijmu.edu.cn.
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D055815:Young Adult