title: Neurological examination combined with brain MRI or cranial US improves prediction of neurological outcome in preterm infants.
abstract: BACKGROUND
  The predictive value of the combination of neurological examination and brain magnetic resonance imaging (MRI) or cranial ultrasound (cUS) in preterm infants is not known.
  
  
  OBJECTIVE
  To study the prognostic value of the combination of neurological examination and brain MRI at term equivalent age (TEA) or serial neonatal cUS in very preterm infants for neurosensory outcome at 2 years of corrected age.
  
  
  METHODS
  A prospective follow-up study.
  
  
  METHODS
  A total of 216 very preterm infants (birth weight 1132 g [SD 331 g]) born in Turku University Hospital, from 2001 to 2006, were included.
  
  
  METHODS
  The Dubowitz neurologic examination and brain MRI were done at TEA, and serial cUS examinations were performed until TEA. The Hammersmith Infant Neurological Examination (HINE) and neurosensory impairments (NSI) were assessed at 2 years of corrected age.
  
  
  RESULTS
  Of all infants, 163 (76%) had one or more deviant neurological items at TEA, and 32 (15%) had the HINE total score below the 10th percentile at 2 years of corrected age. A total of 17 (8%) infants had NSI. Neurological examination at TEA improved the negative and positive predictive values of brain MRI for NSI from 99% to 100%, and from 28% to 35%, respectively, and the negative and positive predictive values of cUS from 97% to 100%, and from 61% to 79%, respectively.
  
  
  CONCLUSIONS
  The combination of the Dubowitz neurologic examination and the brain MRI at TEA or serial neonatal cUS provides a valuable clinical tool for predicting long-term neurosensory outcome in preterm infants.
authors.affiliation: Department of Pediatric Neurology, University of Turku, Turku University Hospital, Turku, Finland. Electronic address: sirkku.a.setanen@utu.fi.
authors.forename: Sirkku
authors.initials: S
authors.lastname: Setänen
authors.affiliation: Department of Medicine, University of Turku, Turku, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Lahti
authors.affiliation: Department of Pediatrics, University of Turku, Turku University Hospital, Turku, Finland.
authors.forename: Liisa
authors.initials: L
authors.lastname: Lehtonen
authors.affiliation: Turku PET Center, Turku University Hospital, Turku, Finland.
authors.forename: Riitta
authors.initials: R
authors.lastname: Parkkola
authors.affiliation: Department of Pediatric Psychiatry, University of Turku, Turku University Hospital, Turku, Finland.
authors.forename: Jonna
authors.initials: J
authors.lastname: Maunu
authors.affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland.
authors.forename: Katriina
authors.initials: K
authors.lastname: Saarinen
authors.affiliation: Department of Pediatric Neurology, University of Turku, Turku University Hospital, Turku, Finland.
authors.forename: Leena
authors.initials: L
authors.lastname: Haataja
mesh_terms: D002675:Child, Preschool; D004453:Echoencephalography; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D019102:Infant, Very Low Birth Weight / Q000254:growth & development / Q000502:physiology*; D009422:Nervous System Diseases / Q000175:diagnosis*; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies
keywords: Cerebral palsy; Long-term development; Predictive value; The Dubowitz neurologic examination; The Hammersmith Infant Neurological Examination