title: [Metabolic lung function upon activation of the substantia nigra and in conditions of gabaergic mediation of the amygdala and brainstem structures].
abstract: The study presents a comprehensive assessment of the integration of metabolic functions of the lungs when the focus of pathologic activity forms in the substantia nigra and when GABA is introduced into the central nucleus of the amygdala and into the giant cell reticular nucleus of the medulla oblongata. The experimental studies were conducted on laboratory rats. It was established that GABAergic mediation of efferent nigral influences contributes to the optimization of the surface-active properties of surfactant lipids and to the restoration of the blood supply and fluid balance in the lungs which were modified modelling the dysfunction of the substantia nigra and preserving the endothelial dysfunction in the pulmonary circulation.
authors.forename: S A
authors.initials: SA
authors.lastname: Lukina
authors.forename: M R
authors.initials: MR
authors.lastname: Timofeeva
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D050356:Lipid Metabolism / Q000187:drug effects; D008168:Lung / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D011663:Pulmonary Surfactants; D005680:gamma-Aminobutyric Acid