title: Allogeneic hematopoietic cell transplantation in adult patients with acute lymphoblastic leukemia.
abstract: This review discusses the use of prognostic factors, patient and donor selection, choice of conditioning regimens, and timing of transplant. It also describes the management of Philadelphia-positive acute lymphocytic leukemia (ALL) and central nervous system disease. All aggressively treated adults with ALL should be considered for allogeneic transplantation and tissue typed at diagnosis. We further suggest that eligible patients be entered into clinical trials (that incorporate transplantation); these unselected prospective outcome data are essential to evaluate the true value of allogeneic transplantation in adults with ALL.
authors.affiliation: Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK. Electronic address: David.Marks@UHBristol.nhs.uk.
authors.forename: David I
authors.initials: DI
authors.lastname: Marks
authors.affiliation: Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Alonso
authors.affiliation: Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK.
authors.forename: Rohini
authors.initials: R
authors.lastname: Radia
mesh_terms: D000328:Adult; D001782:Blood Donors; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
keywords: Acute lymphoblastic leukemia; Allogeneic hematopoietic cell transplantation; Pretransplant conditioning; Prognostic factors; Timing of transplant