title: [Radiotherapy of a glioma in a pregnant woman: evaluation of the foetal dose in conformational 3D or intensity-modulated].
abstract: The purpose was to assess three treatments planning techniques including one in intensity-modulated radiation therapy (IMRT) for cerebral irradiation of pregnant woman, in order to limit the dose delivered to the foetus. The treatment provided was 60 Gy to the planning target volume. Estimated foetal dose was measured using an anthropomorphic phantom, on the upper and middle part of the uterus. The first plan consisted in four beams in conformational technique delivered from a Varian accelerator with a 120 leaves collimator, the second one used non-coplanar fields and the third one assessed IMRT. With the conformational technique, the dose at the upper part of the uterus was 8.3 mGy and 6.3 mGy at the middle part. The dose delivered to the foetus was higher with the non-coplanar fields. In IMRT, the dose at the upper part of the uterus was 23.8 mGy and 14.3 mGy at the middle part. The three plans used 6 MV X-rays. Because of the use of leaves and non-coplanar fields, IMRT does not seem to be the optimal technique for the treatment of pregnant woman. However, the dose delivered to the foetus remains low and below the dose of 100 mGy recommended by the International Commission of Radiological Protection. It seems possible to consider the use of this technique for a better sparing of organs at risk for the mother.
authors.affiliation: Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen cedex 1, France.
authors.forename: L
authors.initials: L
authors.lastname: Lefebvre
authors.affiliation: Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen cedex 1, France.
authors.forename: K
authors.initials: K
authors.lastname: Doyeux
authors.affiliation: Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen cedex 1, France.
authors.forename: S
authors.initials: S
authors.lastname: Linca
authors.affiliation: Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen cedex 1, France.
authors.forename: T
authors.initials: T
authors.lastname: Challand
authors.affiliation: Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen cedex 1, France. Electronic address: Chantal.hanzen@chb.unicancer.fr.
authors.forename: C
authors.initials: C
authors.lastname: Hanzen
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated
keywords: Cranial irradiation; Femme enceinte; Glioma; Gliome; Intensity-modulated; Irradiation cérébrale; Pregnant women; Radiotherapy; Radiothérapie conformationelle en modulation d’intensité