title: Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections.
abstract: The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak poses a serious threat to public health. Here, we summarize recent advances in identifying human neutralizing monoclonal antibodies (mAbs) against MERS-CoV, describe their mechanisms of action, and analyze their potential for treatment of MERS-CoV infections.
authors.affiliation: Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Rd., Shanghai 200032, China. Electronic address: tlying@fudan.edu.cn.
authors.forename: Tianlei
authors.initials: T
authors.lastname: Ying
authors.affiliation: Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Rd., Shanghai 200032, China.
authors.forename: Haoyang
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Rd., Shanghai 200032, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
authors.forename: Dimiter S
authors.initials: DS
authors.lastname: Dimitrov
authors.affiliation: Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Rd., Shanghai 200032, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
authors.forename: Shibo
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D057134:Antibodies, Neutralizing / Q000276:immunology / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000276:immunology / Q000627:therapeutic use; D003140:Communicable Disease Control; D018352:Coronavirus Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008877:Middle East; D065207:Middle East Respiratory Syndrome Coronavirus / Q000276:immunology*; D009500:Neutralization Tests
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Coronavirus; MERS-CoV; Receptor binding domain (RBD); mAbs