title: Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease?
abstract: BACKGROUND
  Papillary carcinoma is the most common malignant thyroid neoplasm. The effect of the concurrent presence of Hashimoto's thyroiditis and papillary thyroid carcinoma remains controversial.
  
  
  OBJECTIVE
  To evaluate the association between Hashimoto's thyroiditis and clinicopathological parameters in thyroid papillary carcinoma cases, based on an historical institutional cohort analysis.
  
  
  METHODS
  Cross-sectional study obtained from a historical cohort, including all cases submitted to thyroidectomy for papillary thyroid carcinoma in a single institution during an 11-year period study.
  
  
  RESULTS
  A total of 417 patients with papillary thyroid carcinoma were enrolled; 148 (35.4%) also had Hashimoto's thyroiditis. A female predominance among cases associated to Hashimoto's thyroiditis was observed. The thyroid tumor, in cases associated with Hashimoto's thyroiditis, had a smaller mean diameter, lower frequency of extra-thyroid extension, and earlier clinicopathological staging.
  
  
  CONCLUSIONS
  A high proportion of papillary thyroid carcinoma cases are associated with Hashimoto's thyroiditis. There are associations among these cases with several histopathological factors already recognized for their prognostic value, which by themselves could impact outcomes.
authors.affiliation: Head and Neck Surgery Department, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address: fabiomgirardi@gmail.com.
authors.forename: Fábio Muradás
authors.initials: FM
authors.lastname: Girardi
authors.affiliation: Pathology Department, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Marinez Bizarro
authors.initials: MB
authors.lastname: Barra
authors.affiliation: Pathology Department, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Cláudio Galleano
authors.initials: CG
authors.lastname: Zettler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology*; D013965:Thyroidectomy; D055815:Young Adult
keywords: Carcinoma papilar; Neoplasias da glândula tireoide; Papillary carcinoma; Prognosis; Prognóstico; Thyroid neoplasms