title: Early identification and management of patients with severe sepsis and septic shock in the emergency department.
abstract: Severe sepsis and septic shock have great relevance to Emergency Medicine physicians because of their high prevalence, morbidity, and mortality. Treatment is time-sensitive, depends on early identification risk stratification, and has the potential to significantly improve patient outcomes. In this article, we review the pathophysiology of, and evidence basis for, the emergency department management of severe sepsis and septic shock.
authors.affiliation: Department of Emergency Medicine, Yale School of Medicine, 464 Congress Avenue, Suite 260, New Haven, CT 06450, USA. Electronic address: josh.keegan@gmail.com.
authors.forename: Joshua
authors.initials: J
authors.lastname: Keegan
authors.affiliation: Department of Emergency Medicine, Yale School of Medicine, 464 Congress Avenue, Suite 260, New Haven, CT 06450, USA.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Wira
mesh_terms: D000465:Algorithms; D004636:Emergency Service, Hospital; D006801:Humans; D018570:Risk Assessment; D018805:Sepsis / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012772:Shock, Septic / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents
keywords: Early goal-directed therapy; Organ dysfunction; Sepsis; Sepsis bundles; Shock