title: FKBP5 moderation of depressive symptoms in peer victimized, post-institutionalized children.
abstract: The purpose of this study was to examine whether FKBP5 rs1360780 moderates relations between different forms of life stress/adversity (early institutional rearing and peer victimization) and depressive symptoms in adolescents. As reported previously, PI youth were at risk for being victimized by peers. Here, victimization was associated with elevated depressive symptoms. While FKBP5 did not moderate the association between early life adversity and depressive symptoms for either sex, it moderated the association between current adversity and depressive symptoms for victimized girls carrying the minor allele. Consistent with a differential susceptibility model, girls with the minor allele exhibited more depressive symptoms at higher levels of victimization, but fewer depressive symptoms at lower levels of victimization. Interestingly, boys with the CC genotype had higher rates of depressive symptoms compared to girls with the CC genotype in the context of heightened victimization.
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States. Electronic address: vanz0037@umn.edu.
authors.forename: Adrienne A
authors.initials: AA
authors.lastname: VanZomeren-Dohm
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States.
authors.forename: Clio E
authors.initials: CE
authors.lastname: Pitula
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States.
authors.forename: Kalsea J
authors.initials: KJ
authors.lastname: Koss
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Thomas
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States.
authors.forename: Megan R
authors.initials: MR
authors.lastname: Gunnar
mesh_terms: D000293:Adolescent; D000483:Alleles; D058445:Bullying / Q000523:psychology*; D002648:Child; D002674:Child, Institutionalized / Q000523:psychology*; D019548:Crime Victims; D003863:Depression / Q000235:genetics* / Q000523:psychology; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008297:Male; D010379:Peer Group; D012737:Sex Factors; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: Adolescents; Adoption; Depressive symptoms; FKBP5; Orphanage; Peer victimization