title: First trimester cervical length is associated with mid-trimester loss.
abstract: OBJECTIVE
  To study the value of the cervical length (CL) measurement at 11-14 weeks in predicting second trimester miscarriage occurring at 16-24 weeks.
  
  
  METHODS
  Prospective study in routine obstetric population using transvaginal ultrasound examination to measure the length of the endocervical canal at 11-14 weeks.
  
  
  RESULTS
  The study group consisted of 2836 singleton pregnancies. Eleven (0.0038%) women miscarried between 16 and 24 weeks whereas 2825 delivered after 34 weeks. CL was significantly shorter (Mann-Whitney U test, p = 0.001), in women that had a second trimester miscarriage in comparison to those who delivered after 34 weeks (median CL 28 mm versus 32 mm, respectively). First trimester CL was predictive of a late miscarriage (OR = 0.7093304, R(2 )= 0.1211, AUC = 0.7838, p < 0.001). The detection rate was 63.64% for 20% screen positive rate.
  
  
  CONCLUSIONS
  First trimester endocervix is significantly shorter in women destined to miscarry between 16 and 24 weeks. In low risk singleton pregnancies, first trimester CL can be useful in predicting second trimester miscarriage.
authors.affiliation: a Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology , Athens Medical School, National and Kapodistrian University of Athens, 'Attikon' University Hospital , Athens , Greece .|b Fetal Medicine Unit , Leto Maternity Hospital , Athens , Greece , and.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Papastefanou
authors.affiliation: c Fetal Medicine Unit, Department of Obstetrics and Gynecology , Rhodos General Hospital , Rhodes , Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kavalakis
authors.affiliation: a Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology , Athens Medical School, National and Kapodistrian University of Athens, 'Attikon' University Hospital , Athens , Greece .|b Fetal Medicine Unit , Leto Maternity Hospital , Athens , Greece , and.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Pilalis
authors.affiliation: a Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology , Athens Medical School, National and Kapodistrian University of Athens, 'Attikon' University Hospital , Athens , Greece .|b Fetal Medicine Unit , Leto Maternity Hospital , Athens , Greece , and.
authors.forename: Makarios
authors.initials: M
authors.lastname: Eleftheriades
authors.affiliation: a Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology , Athens Medical School, National and Kapodistrian University of Athens, 'Attikon' University Hospital , Athens , Greece .|b Fetal Medicine Unit , Leto Maternity Hospital , Athens , Greece , and.
authors.forename: Athena P
authors.initials: AP
authors.lastname: Souka
mesh_terms: D000022:Abortion, Spontaneous / Q000000981:diagnostic imaging* / Q000453:epidemiology; D054791:Cervical Length Measurement / Q000706:statistics & numerical data*; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies
keywords: Cervix; first trimester ultrasound; late miscarriage; mid-trimester loss; screening