title: Genome sequence of type strain Paenibacillus polymyxa DSM 365, a highly efficient producer of optically active (R,R)-2,3-butanediol.
abstract: Paenibacillus polymyxa DSM 365, an efficient producer of (R,R)-2,3-butanediol, is known to show the highest production titer and productivity reported to date. Here, the first draft genome sequence of this promising strain may provide the genetic basis for further insights into the molecular mechanisms underlying the production of (R,R)-2,3-butanediol with high optical purity and at a high titer. It will also facilitate the design of rational strategies for further strain improvements, as well as construction of artificial biosynthetic pathways through synthetic biology for asymmetric synthesis of chiral 2,3-butanediol or acetoin in common microbial hosts.
authors.affiliation: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China.
authors.forename: Neng-Zhong
authors.initials: NZ
authors.lastname: Xie
authors.affiliation: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China.
authors.forename: Jian-Xiu
authors.initials: JX
authors.lastname: Li
authors.affiliation: Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse 15, Hamburg 21073, Germany.
authors.forename: Li-Fu
authors.initials: LF
authors.lastname: Song
authors.affiliation: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, NO. 1 Beichen West Road, Beijing 100101, China.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Hou
authors.affiliation: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.affiliation: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China.
authors.forename: Qi-Shi
authors.initials: QS
authors.lastname: Du
authors.affiliation: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, NO. 1 Beichen West Road, Beijing 100101, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China. Electronic address: rbhuang@gxas.ac.cn.
authors.forename: Ri-Bo
authors.initials: RB
authors.lastname: Huang
mesh_terms: D002072:Butylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D056507:Paenibacillus / Q000235:genetics* / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D002072:Butylene Glycols; C026978:2,3-butylene glycol
keywords: (R,R)-2,3-butanediol; Genome sequence; High optical purity; Paenibacillus polymyxa