title: Oral changes in individuals undergoing hematopoietic stem cell transplantation.
abstract: BACKGROUND
  Patients undergoing hematopoietic stem cell transplantation receive high doses of chemotherapy and radiotherapy, which cause severe immunosuppression.
  
  
  OBJECTIVE
  To report an oral disease management protocol before and after hematopoietic stem cell transplantation.
  
  
  METHODS
  A prospective study was carried out with 65 patients aged>18 years, with hematological diseases, who were allocated into two groups: A (allogeneic transplant, 34 patients); B (autologous transplant, 31 patients). A total of three dental status assessments were performed: in the pre-transplantation period (moment 1), one week after stem cell infusion (moment 2), and 100 days after transplantation (moment 3). In each moment, oral changes were assigned scores and classified as mild, moderate, and severe risks.
  
  
  RESULTS
  The most frequent pathological conditions were gingivitis, pericoronitis in the third molar region, and ulcers at the third moment assessments. However, at moments 2 and 3, the most common disease was mucositis associated with toxicity from the drugs used in the immunosuppression.
  
  
  CONCLUSIONS
  Mucositis accounted for the increased score and potential risk of clinical complications. Gingivitis, ulcers, and pericoronitis were other changes identified as potential risk factors for clinical complications.
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil.
authors.forename: Regina Haddad
authors.initials: RH
authors.lastname: Barrach
authors.affiliation: Hospital Amaral Carvalho, Jaú, SP, Brazil.
authors.forename: Mair Pedro de
authors.initials: MP
authors.lastname: Souza
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil. Electronic address: daniela-polo@uol.com.br.
authors.forename: Daniela Polo Camargo da
authors.initials: DP
authors.lastname: Silva
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil.
authors.forename: Priscila Suman
authors.initials: PS
authors.lastname: Lopez
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil.
authors.forename: Jair Cortez
authors.initials: JC
authors.lastname: Montovani
mesh_terms: D000293:Adolescent; D006402:Hematologic Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D009059:Mouth Diseases / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors
keywords: Hematopoietic stem cell transplantation; Medical oncology; Mucosite; Mucositis; Oncologia; Sistema hematopoético