title: Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: a randomized controlled trial in polypectomized participants.
abstract: To address preventive effects of n-3 PUFAs/LC n-3 PUFAs on CRTs, a randomized controlled trial was conducted. One-hundred four experimental group participants were advised to increase intake of n-3 PUFAs, including fish/shell fish, fish oil supplements and perilla oils, and to decrease consumption of n-6 PUFAs and fats/oils as a whole for 24 months. One-hundred one control group participants were only cautioned to reduce consumption of fats/oils as a whole. Random allocation was satisfactorily attained, and participants sufficiently complied with our regimen. Intakes, plasma concentrations, and compositions of the RBC and sigmoid colon membranes of n-3 PUFAs, LC n-3 PUFAs, EPA and DHA increased, and the ratios of n-6 PUFAs/n-3 PUFAs and AA/LC n-3 PUFAs decreased without any adverse response. Twenty-four months after the intervention, the multivariate-adjusted hazard ratio (95% confidence intervals) was estimated to be 0.805 (0.536-1.209) with a signal towards the reduced CRT incidence.
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan; Social Welfare Institutions Seizanri-kai, Biwajima Care Center, Nishi-ku, Nagoya, Japan. Electronic address: tokudome2013@gmail.com.
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Department of Nutrition and Health Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Kuriki
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Nagoya Medical Association Health Care Center, Higashi-ku, Nagoya, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Department of Gastroenterology, Aichi Medical University, Nagakute, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Nagoya City Rehabilitation Center, Mizuho-ku, Nagoya, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shirai
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Department of Food Science and Nutrition, Nagoya Women's University, Mizuho-ku, Nagoya, Japan.
authors.forename: Nahomi
authors.initials: N
authors.lastname: Imaeda
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; Department of Health and Nutrition, Nagoya Bunri University, Inazawa, Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Goto
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan; School of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tokudome
authors.affiliation: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Ichikawa
authors.affiliation: Institute for Consumer Science and Human Life, Kinjo Gakuin University, Moriyama-ku, Nagoya, Japan.
authors.forename: Harumi
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control* / Q000601:surgery; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D055118:Medication Adherence; D016896:Treatment Outcome
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3
keywords: Colorectal tumors; Dietary intervention; Polypectomized participants; Randomized controlled trial; n-3 polyunsaturated fatty acids