title: Role of sulfiredoxin in systemic diseases influenced by oxidative stress.
abstract: Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions.
authors.affiliation: Department of Periodontics, Saveetha Dental College and Hospitals, 162, Poonamallee High Road, Vellappanchavadi, Chennai, Tamil Nadu 600077, India. Electronic address: ash.periopg@gmail.com.
authors.forename: Asha
authors.initials: A
authors.lastname: Ramesh
authors.affiliation: Department of Periodontics, Saveetha Dental College and Hospitals, 162, Poonamallee High Road, Vellappanchavadi, Chennai, Tamil Nadu 600077, India. Electronic address: drsheeja@rediffmail.com.
authors.forename: Sheeja S
authors.initials: SS
authors.lastname: Varghese
authors.affiliation: Department of Periodontics, Saveetha Dental College and Hospitals, 162, Poonamallee High Road, Vellappanchavadi, Chennai, Tamil Nadu 600077, India. Electronic address: principaldental@saveetha.com.
authors.forename: Jayakumar
authors.initials: J
authors.lastname: Doraiswamy
authors.affiliation: Department of Periodontics, Saveetha Dental College and Hospitals, 162, Poonamallee High Road, Vellappanchavadi, Chennai, Tamil Nadu 600077, India. Electronic address: msankari@gmail.com.
authors.forename: Sankari
authors.initials: S
authors.lastname: Malaiappan
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000235:genetics / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; D050862:Oxidoreductases Acting on Sulfur Group Donors; C504024:SRXN1 protein, human
keywords: Antioxidant; Oxidative stress; Reactive oxygen species; Sulfiredoxin; Systemic diseases