title: Aurora-A kinase: potential tumor marker of osteosarcoma.
abstract: Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.
authors.affiliation: Department of Orthopedic Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China.
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Zhu
authors.forename: Jiong
authors.initials: J
authors.lastname: Mei
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D064096:Aurora Kinase A / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology; D012516:Osteosarcoma / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D064096:Aurora Kinase A