title: [Clinical aspects of vaso-and cardioprotection in patients with primary and recurrent myocardial infarction].
abstract: The paper is devoted to characteristics of vascular and cardiac remodeling in patients with primary and recurrent myocardial infarction (MI). Data on multifocal atheroslerotic involvement of vessels in these patients associated with development of multivascular involvement of coronary arteries are presented. Emphasis is made on remodeling of vessels and the heart, parameters of vasodilation. We have elucidated frequency of vascular vasoconstrictory reactions in acute stage of MI and relationship between vascular and myocardial remodeling. Special consideration is given to possibility of correction of vascular vasoconstrictory reaction with indapamide. We have corroborated its administration starting from first days of treatment and demonstrated its effect during use for 3 months. We have established possibility of normalization of endothelium dependent vasodilation in most patients with primary MI. Expedience of the use of indapamide for prevention of development of chronic heart failure is stressed.
authors.forename: R S
authors.initials: RS
authors.lastname: Bogachev
authors.forename: V S
authors.initials: VS
authors.lastname: Rfeenkova
authors.forename: D V
authors.initials: DV
authors.lastname: Kober
authors.forename: A P
authors.initials: AP
authors.lastname: Kraĭtser
mesh_terms: D002316:Cardiotonic Agents / Q000008:administration & dosage; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000503:physiopathology*; D004338:Drug Combinations; D045462:Endothelium-Dependent Relaxing Factors / Q000008:administration & dosage; D005263:Femoral Artery / Q000503:physiopathology*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D007190:Indapamide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D020913:Perindopril / Q000008:administration & dosage*; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D014661:Vasoconstriction / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D002316:Cardiotonic Agents; D004338:Drug Combinations; D045462:Endothelium-Dependent Relaxing Factors; D007190:Indapamide; D020913:Perindopril