title: Multicomponent reactions in antimitotic drug discovery.
abstract: As enabling technology, the development and application of multicomponent reactions (MCRs) are now an integral part of the work of any major medical research unit. Targeted MCR approaches focused on specific antimitotic pathways afford new solutions for the medicinal chemistry of the XXI century. In this review, the contribution of these procedures to the discovery of antimitotic drugs that are currently in clinical trials or already in the market is discussed.
authors.forename: Angel
authors.initials: A
authors.lastname: Cores
authors.forename: Carlos
authors.initials: C
authors.lastname: Carbajales
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials. University of Santiago de Compostela. Spain. albertojose.coelho@usc.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
mesh_terms: D000818:Animals; D050256:Antimitotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D064127:Aurora Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D055808:Drug Discovery; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*; D062105:Molecular Docking Simulation; D020409:Molecular Motor Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008941:Spindle Apparatus / Q000737:chemistry / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D050256:Antimitotic Agents; D000970:Antineoplastic Agents; D020409:Molecular Motor Proteins; D047428:Protein Kinase Inhibitors; D064127:Aurora Kinases