title: Langerhans cell histiocytosis presenting as hypothyroid goitre: a unique presentation.
abstract: Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease.
authors.affiliation: Department of Internal Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Krishna Chaitanya
authors.initials: KC
authors.lastname: Marupudi
authors.affiliation: Department of Internal Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Suman S
authors.initials: SS
authors.lastname: Karanth
authors.affiliation: Department of Medical Oncology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Joseph
authors.initials: J
authors.lastname: Thomas
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006042:Goiter / Q000175:diagnosis / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D035583:Rare Diseases; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D014747:Vinblastine; D011239:Prednisolone