title: Linking DNA damage, NAD(+)/SIRT1, and aging.
abstract: Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP.
authors.affiliation: Novartis Professor of Biology, Director of the Glenn Labs for the Science of Aging, and Affiliate of the Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address: leng@mit.edu.
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D019588:Aging, Premature / Q000178:diet therapy* / Q000209:etiology*; D000818:Animals; D003057:Cockayne Syndrome / Q000150:complications*; D059305:Diet, High-Fat; D006801:Humans; D009243:NAD / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: D009243:NAD; D056564:Sirtuin 1