title: Perfusion and ventilation filters for Fourier-decomposition MR lung imaging.
abstract: MR imaging without the use of contrast agents has recently been used for creating perfusion and ventilation functional lung images. The technique incorporates frequency- or wavelet-domain filters to separate the MR signal components. This paper presents a new, subject-adaptive algorithm for perfusion and ventilation filters design. The proposed algorithm uses a lung signal model for separation of the signal components in the frequency domain. Non-stationary lung signals are handled by a short time Fourier transform. This method was applied to sets of 192 and 90 co-registered non-contrast MR lung images measured for five healthy subjects at the rate of 3,33 images per second, using different slice thicknesses. In each case, the resulted perfusion and ventilation images showed a smaller amount of mutual information, when compared to those obtained using the known lowpass/highpass filter approach.
authors.affiliation: Institute of Electronics, Lodz University of Technology, 90-924 Lodz, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Wujcicki
authors.affiliation: Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
authors.forename: Dominique
authors.initials: D
authors.lastname: Corteville
authors.affiliation: Institute of Electronics, Lodz University of Technology, 90-924 Lodz, Poland. Electronic address: amaterka@gmail.com.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Materka
authors.affiliation: Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Schad
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D011652:Pulmonary Circulation / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Perfusion imaging; Perfusionsbildgebung; Ventilationsbildgebung; functional FD lung MRI; funktionelle FD Lungen-MRT; kontrastmittelfreie Lungen-MRT; non-contrast lung MRI; ventilation imaging