title: Diagnosis of thyroid nodules using virtual touch tissue quantification value and anteroposterior/transverse diameter ratio.
abstract: This paper proposes an effective approach to differential diagnosis of thyroid nodules using a hierarchical classification model based on the Virtual Touch tissue quantification (VTQ) value and anteroposterior/transverse diameter (A/T) ratio. One hundred twenty nodules (92 benign, 28 malignant) were analyzed using this approach by combining the quantitative elastic characteristic with the conventional sonographic feature. First, nodules were classified as benign (VTQ values <2.27 m/s), malignant (VTQ values >2.73 m/s) and indeterminate (2.27 m/s ≤ VTQ values ≤2.73 m/s) using two cutoff points selected on the basis of receiver operating characteristic analysis. Second, the indeterminate nodules were separated into malignant and benign nodules using an A/T ratio ≥1. The advantage of this approach was that it could alleviate the limitation of an overlap in VTQ values between benign and malignant nodules. According to the pathologic results, the accuracy of this approach was 95%. The proposed approach may potentially improve diagnostic accuracy.
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, HuBei Province, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Wuhan General Hospital of Guangzhou Command, People's Liberation Army, Wuhan, HuBei Province, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhou
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, HuBei Province, People's Republic of China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, HuBei Province, People's Republic of China. Electronic address: myding@mail.hust.edu.cn.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Ding
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, HuBei Province, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yuchi
authors.affiliation: Department of Medical Engineering, Wuhan General Hospital of Guangzhou Command, People's Liberation Army, Wuhan, HuBei Province, People's Republic of China.
authors.forename: Yiyong
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D016606:Thyroid Nodule / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Anteroposterior/transverse diameter ratio; Thyroid nodules; Ultrasound; Virtual touch tissue quantification value