title: Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!
abstract: Recently we have documented research efforts aimed at new classes of oxetanes as well as spiroheteroalicyclic ring systems (which we have termed 'Compact Modules') designed to expand the palette of tailored module scaffolds available to medicinal chemists, which constitute an important role for synthetic chemistry in the drug discovery process. An essential component for this process is to provide access to specific molecular topologies with functional group diversity, essential for generating leads that discriminate among biological targets, therefore promoting selectivity and enhancing the safety profile of the final clinical candidates.
authors.affiliation: F. Hoffmann-La Roche AG Pharma Research and Early Development Discovery Chemistry Roche Innovation Center, Basel Grenzacherstrasse CH-4070 Basel, Switzerland. mark.rogers-evans@roche.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Rogers-Evans
authors.affiliation: F. Hoffmann-La Roche AG Pharma Research and Early Development Discovery Chemistry Roche Innovation Center Basel Grenzacherstrasse CH-4070 Basel, Switzerland.
authors.forename: Henner
authors.initials: H
authors.lastname: Knust
authors.affiliation: F. Hoffmann-La Roche AG Pharma Research and Early Development Discovery Chemistry Roche Innovation Center Basel Grenzacherstrasse CH-4070 Basel, Switzerland.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Plancher
authors.affiliation: Laboratorium für Organische Chemie der ETH Vladimir Prelog Weg 3 CH-8093 Zürich, Switzerland.
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
authors.affiliation: Laboratorium für Organische Chemie der ETH Vladimir Prelog Weg 3 CH-8093 Zürich, Switzerland.
authors.forename: George
authors.initials: G
authors.lastname: Wuitschik
authors.affiliation: Laboratorium für Organische Chemie der ETH Vladimir Prelog Weg 3 CH-8093 Zürich, Switzerland.
authors.forename: Johannes
authors.initials: J
authors.lastname: Burkhard
authors.affiliation: Laboratorium für Organische Chemie der ETH Vladimir Prelog Weg 3 CH-8093 Zürich, Switzerland.
authors.forename: Dong B
authors.initials: DB
authors.lastname: Li
authors.affiliation: Laboratorium für Organische Chemie der ETH Vladimir Prelog Weg 3 CH-8093 Zürich, Switzerland.
authors.forename: Carine
authors.initials: C
authors.lastname: Guérot
mesh_terms: D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry*; D055808:Drug Discovery; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001384:Azetidines; D004988:Ethers, Cyclic; D013141:Spiro Compounds; C005287:oxetane