title: Changes in immunity parameters and blood cytokine concentrations after chronic nitrile acrylate intoxication.
abstract: Experiments on outbred albino rats showed that chronic nitrile acrylate intoxication (60 days, 0.05 LD50 per day subcutaneously) led to reduction of T-dependent humoral immune response (T-independent humoral immune response was less affected); parameters cell immunity were suppressed to a greater extent than parameters of humoral immune reactions. Equal attenuation of the functions of Th1 and Th2 lymphocytes, decrease of the blood levels of immunoregulatory, pro- and anti-inflammatory cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-13), and decrease of acetyl cholinesterase activity in thymic and splenic T lymphocytes were observed.
authors.affiliation: Saratov Affiliated Department of REAVIZ Samara Medical Institute, Saratov, Russia, pfzabrodsky@gmail.com.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: M S
authors.initials: MS
authors.lastname: Gromov
authors.forename: V V
authors.initials: VV
authors.lastname: Maslyakov
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D007111:Immunity, Cellular / Q000187:drug effects*; D056724:Immunity, Humoral / Q000187:drug effects*; D009570:Nitriles / Q000633:toxicity*; D051381:Rats; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D000179:Acrylates; D016207:Cytokines; D009570:Nitriles; D000110:Acetylcholinesterase