title: Executive-affective connectivity in smokers viewing anti-smoking images: an fMRI study.
abstract: Despite knowledge of the harmful consequences of smoking on health, tobacco users continue to smoke. Neuroimaging studies have begun to provide insight into the mechanisms underlying this response. Regions involved in executive control and affective processing/persuasion are activated when viewing the negative value of smoking, but these systems can interact in ways that promote or hinder its impact on behavior. The goal of this functional magnetic resonance imaging (fMRI) study was to examine the dynamics between these systems during the processing of images designed to elicit a negative emotional response regarding tobacco smoking in a group of current smokers. Thirty chronic smokers passively viewed aversive smoking-related, aversive nonsmoking-related and neutral images presented in a block design while being scanned. Functional connectivity analyses showed that the left inferior frontal gyrus (IFG) is negatively associated to activity in medial frontal, cingulate, limbic, subcortical and parietal regions in chronic smokers during the processing of aversive smoking-related material, a pattern that was significantly greater when stimuli were drug-related compared with when they were nondrug-related. Our results suggest that individuals with tobacco dependence present different patterns of functional connectivity depending on whether the aversive stimuli are smoking- or nonsmoking-related. Activity in the left inferior frontal gyrus may act to down-regulate corresponding activity in regions key to an affective and persuasive response during the processing of anti-smoking material. This mechanism may reduce the extent to which "feeling bad" brings about a change in behavior.
authors.affiliation: Centre de recherche de l׳Institut Universitaire en Santé Mentale de Montréal and Department of Psychiatry, University of Montreal, Montreal, Canada.
authors.forename: Laurence
authors.initials: L
authors.lastname: Dinh-Williams
authors.affiliation: Centre de recherche de l׳Institut Universitaire en Santé Mentale de Montréal and Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Bishop׳s University, Sherbrooke, Canada.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mendrek
authors.affiliation: Centre de recherche de l׳Institut Universitaire en Santé Mentale de Montréal and Department of Psychiatry, University of Montreal, Montreal, Canada; Institut Philippe-Pinel de Montréal, Montreal, Canada.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Dumais
authors.affiliation: Centre de recherche de l׳Institut Universitaire en Santé Mentale de Montréal and Department of Psychiatry, University of Montreal, Montreal, Canada.
authors.forename: Josiane
authors.initials: J
authors.lastname: Bourque
authors.affiliation: Centre de recherche de l׳Institut Universitaire en Santé Mentale de Montréal and Department of Psychiatry, University of Montreal, Montreal, Canada. Electronic address: stephane.potvin@umontreal.ca.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Potvin
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D054022:Cerebrum / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000503:physiopathology* / Q000523:psychology; D014029:Tobacco Use Disorder / Q000503:physiopathology* / Q000523:psychology; D055815:Young Adult
keywords: Addiction; Anti-smoking; Emotion; Inferior frontal gyrus; Tobacco; fMRI