title: Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS).
abstract: OBJECTIVE
  To examine whether coenzyme Q10, a potent antioxidant, is associated with risk of dementia, which has not yet been elucidated.
  
  
  RESULTS
  We performed a case-control study nested in a community-based cohort of approximately 6000 Japanese aged 40-69 years at baseline (1984-1994). Serum coenzyme Q10 was measured in 65 incident cases of disabling dementia with dementia-related behavioral disturbance or cognitive impairment incident between 1999 and 2004, and in 130 age-, sex- and baseline year-matched controls. Serum coenzyme Q10 was inversely associated with dementia: the multivariate odds ratios (95% confidence intervals) were 0.68 (0.26-1.78), 0.92 (0.33-2.56), and 0.23 (0.06-0.86) for individuals with the second, third, and highest quartiles of coenzyme Q10, respectively, as compared with the lowest quartile (P for trend = 0.05). A similar association was found for the coenzyme Q10/total cholesterol ratio: the respective ORs were 0.67 (0.25-1.78), 0.73 (0.28-1.92), and 0.21 (0.05-0.90) (P for trend = 0.04).
  
  
  CONCLUSIONS
  Serum coenzyme Q10 levels were inversely associated with risk of disabling dementia.
authors.affiliation: Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan. Electronic address: yamagishi.kazumas.ge@u.tsukuba.ac.jp.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.affiliation: Department of Public Health, Juntendo University, Tokyo, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Ikeda
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Moriyama
authors.affiliation: Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Health Services and Systems Research, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
authors.forename: Choy-Lye
authors.initials: CL
authors.lastname: Chei
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noda
authors.affiliation: Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Public Health, Dokkyo Medical University, Mibu, Japan.
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Umesawa
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Department of Public Health, Dokkyo Medical University, Mibu, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nagao
authors.affiliation: Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
authors.affiliation: School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Japan.
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Antioxidant; Coenzyme Q10; Dementia; Epidemiology; Follow-up study