title: Capsaicin-loaded vesicular systems designed for enhancing localized delivery for psoriasis therapy.
abstract: The aim of the current investigation is to evaluate the potential of capsaicin (CAP)-containing liposomes, niosomes and emulsomes in providing localized and controlled delivery, to improve the topical delivery of drug. CAP-bearing systems were prepared by the film hydration method and compared through various in vitro and in vivo parameters. The TEM photographs suggested that the carrier systems were spherical in shape and nanometric in size range. Skin retention studies of CAP from in vitro and in vivo experiments revealed significantly higher accumulation of drug in the case of the emul-gel formulation. Based on the results, we concluded that the emul-gel may be a potential approach for the topical delivery of CAP, for an effective therapy for psoriasis.
authors.affiliation: a Nanomedicine Research Center, ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: a Nanomedicine Research Center, ISF College of Pharmacy , Moga , Punjab , India.|b Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour University , Sagar , M.P. , India.
authors.forename: Madhu
authors.initials: M
authors.lastname: Gupta
authors.affiliation: a Nanomedicine Research Center, ISF College of Pharmacy , Moga , Punjab , India.|b Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour University , Sagar , M.P. , India.
authors.forename: Sharad
authors.initials: S
authors.lastname: Mangal
authors.affiliation: b Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour University , Sagar , M.P. , India.
authors.forename: Udita
authors.initials: U
authors.lastname: Agrawal
authors.affiliation: a Nanomedicine Research Center, ISF College of Pharmacy , Moga , Punjab , India.|b Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour University , Sagar , M.P. , India.
authors.forename: Suresh Prasad
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002211:Capsaicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D008081:Liposomes; D011565:Psoriasis / Q000188:drug therapy*; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D004655:Emulsions; D008081:Liposomes; D002211:Capsaicin
keywords: capsaicin; localized effect; psoriasis; topical delivery; vesicular system