title: ShcC proteins: brain aging and beyond.
abstract: To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging.
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Orli
authors.initials: O
authors.lastname: Sagi
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel; Judea Regional Research & Development Center, Carmel 90404, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Budovsky
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Marina
authors.initials: M
authors.lastname: Wolfson
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel. Electronic address: vadim.fraifeld@gmail.com.
authors.forename: Vadim E
authors.initials: VE
authors.lastname: Fraifeld
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001932:Brain Neoplasms / Q000503:physiopathology; D006801:Humans; D055765:Shc Signaling Adaptor Proteins / Q000502:physiology*
chemical_list: D055765:Shc Signaling Adaptor Proteins
keywords: Aging; Brain ischemia; Brain tumors; Immunity; ShcC adaptor proteins; Signaling