title: Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer.
abstract: We present first quantitative three-dimensional (3D) data sets recorded using optical coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 transrectal ultrasound guided prostate biopsy specimens from 10 men suspected with prostate cancer were imaged using OCE. 3D quantitative mechanical assessment of biopsy specimens obtained in kilopascals (kPa) at an interval of 40 µm was compared with histopathology. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE in comparison to histopathology. The results show OCE imaging could reliably differentiate between benign prostate tissue, acinar atypical hyperplasia, prostatic intraepithelial neoplasia and malignant PCa. The sensitivity and specificity of OCE for the detection of prostate cancer was 0.98 and 0.91 with AUC > 0.99. Quantitative 3D OCE based on the assessment of mechanical properties of tissues can reliably differentiate prostate tissue specimen in an ex-vivo setting. This is a promising imaging modality for characterising different grades of cancers.
authors.affiliation: Academic Section of Urology, Division of Imaging Technology, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Li
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom; Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, United States.
authors.forename: Guangying
authors.initials: G
authors.lastname: Guan
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ling
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom.
authors.forename: Ying-Ting
authors.initials: YT
authors.lastname: Hsu
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom; Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, United States.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Song
authors.affiliation: Medical Research Institute, Jacqui Wood Cancer Centre, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom.
authors.forename: Jeffrey T-J
authors.initials: JT
authors.lastname: Huang
authors.affiliation: Medical Research Institute, Jacqui Wood Cancer Centre, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom; Department of Pathology, Ninewells Hospital, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Lang
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom; Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, United States.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
authors.affiliation: School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Academic Section of Urology, Division of Imaging Technology, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom. Electronic address: g.nabi@dundee.ac.uk.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Nabi
mesh_terms: D000368:Aged; D054459:Elasticity Imaging Techniques / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
keywords: Optical coherence elastography (OCE); Prostate biopsy; Prostate cancer (PCa); Young's modulus