title: Twenty year follow-up after successful percutaneous balloon mitral valvuloplasty in a large contemporary series of patients with mitral stenosis.
abstract: BACKGROUND
  Percutaneous balloon mitral valvuloplasty (PMV) is currently considered the standard of care for suitable patients with rheumatic mitral stenosis. We sought to assess very long-term outcome after PMV.
  
  
  METHODS
  Between 1991 and 2010, 482 consecutive patients underwent successful PMV in a single center. Procedural success was defined as post-procedural valve area ≥ 1.5 cm(2) and regurgitation moderate or less, without in-hospital major adverse cardiac and cerebro-vascular events. The primary endpoint was 20-year incidence of major adverse cardiac events (MACE), including cardiovascular death and need for mitral surgery or repeat PMV.
  
  
  RESULTS
  Long-term follow-up (mean 11.6 ± 4.9 years; range 0.5 to 20) was completed in 441 (91.5%) patients. The incidence of the primary endpoint was 41.9% (95% confidence interval [CI]: 37.3 to 46.7%). The rate of cardiovascular death, need for mitral surgery or repeat PMV was 9.1% (95% CI: 6.6 to 12.1), 27% (95% CI: 22.9 to 31.4), and 5.9% (95% CI: 3.9 to 8.5), respectively. Cumulative MACE-free survival at 20 years was 35.9 ± 4.7%. At multivariate analysis, male gender (hazard ratio [HR]: 1.99; 95% CI: 1.4-2.8, p < 0.001), echocardiographic score > 8 (HR: 2.19; 95% CI: 1.6-2.9, p < 0.001), atrial fibrillation (HR: 1.54; 95% CI: 1.2-2.1, p = 0.003) and valve area ≤ 1.75 cm(2) after PMV (HR: 3.1; 95% CI: 2.3-4.2, p < 0.001) were identified as independent predictors of the primary endpoint.
  
  
  CONCLUSIONS
  Up to 20 years after successful PMV, a sizeable proportion of patients still exhibit a good clinical result.
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Rome, Italy. Electronic address: f.tomai@tiscali.it.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tomai
authors.affiliation: Department of Medicine, S. Eugenio Hospital, Rome, Italy.
authors.forename: Achille
authors.initials: A
authors.lastname: Gaspardone
authors.affiliation: Cardiology Unit, Cardarelli Hospital, Campobasso, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Versaci
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Rome, Italy.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Ghini
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Altamura
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Rome, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: De Luca
authors.affiliation: Department of Medicine, S. Eugenio Hospital, Rome, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Gioffrè
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Rome, Italy.
authors.forename: Pier Agostino
authors.initials: PA
authors.lastname: Gioffrè
mesh_terms: D000328:Adult; D000368:Aged; D063126:Balloon Valvuloplasty / Q000401:mortality / Q000639:trends*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
keywords: Mitral stenosis; Percutaneous balloon mitral valvuloplasty; Valvular heart disease