title: Clock genes, pancreatic function, and diabetes.
abstract: Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic β cells, glucose homeostasis, and diabetes.
authors.affiliation: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08033 Barcelona, Spain. Electronic address: evieira@ciberdem.org.
authors.forename: Elaine
authors.initials: E
authors.lastname: Vieira
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Burris
authors.affiliation: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08033 Barcelona, Spain; Instituto de Bioingeniería, Universidad Miguel Hernández, 03202 Elche, Spain. Electronic address: ivanq@umh.es.
authors.forename: Ivan
authors.initials: I
authors.lastname: Quesada
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics* / Q000378:metabolism; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*
chemical_list: D007328:Insulin; D056926:CLOCK Proteins
keywords: clock genes; diabetes; insulin; pancreas; β cell