title: Endoscopic endonasal transsphenoidal treatment for acromegaly: 2010 consensus criteria for remission and predictors of outcomes.
abstract: OBJECTIVE
  Acromegaly is a chronic disorder characterized by enhanced growth hormone (GH) secretion and elevated insulin-like growth factor-I (IGF-I) levels, usually caused by pituitary adenomas. In this retrospective study, we reviewed our experience with endoscopic endonasal transsphenoidal surgery (EETS) with in remission rates using the 2010 consensus criteria, predictors of remission and associated complications.
  
  
  METHODS
  The authors retrospectively analyzed data from 56 acromegalic patients who underwent pure EETS. Tumors were classified according to size and suprasellar/parasellar extension. The criteria of remission were GH levels < 1 ng/mL randomly, < 0.4 ng/mL after oral glucose tolerance test and normal IGF-I levels for age and sex within the first 3 and 6 months after surgery.
  
  
  RESULTS
  Biochemical remission was achieved in 4 of 5 microadenomas (80%) and in 33 of 51 macroadenomas (64.7%). The total remission rate was 66.1% (37 of 56 adenomas). Age, gender and suprasellar extension did not affect the remission rate. However, cavernous sinus invasion, sphenoid sinus invasion and history of prior surgery were associated with lower rates of disease control.
  
  
  CONCLUSIONS
  EETS represents an effective and safe option for the treatment of patients with acromegaly. High disease control rates and a small number of complications are some of the most important points related to the technique.
authors.affiliation: Ankara Numune Research and Education Hospital, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Yildirim
authors.forename: Mert
authors.initials: M
authors.lastname: Sahinoglu
authors.forename: Denizhan
authors.initials: D
authors.lastname: Divanlioglu
authors.forename: Fatih
authors.initials: F
authors.lastname: Alagoz
authors.forename: Ahmet Gurhan
authors.initials: AG
authors.lastname: Gurcay
authors.forename: Ergun
authors.initials: E
authors.lastname: Daglioglu
authors.forename: Hilmi Onder
authors.initials: HO
authors.lastname: Okay
authors.forename: Ahmed Deniz
authors.initials: AD
authors.lastname: Belen
mesh_terms: D000172:Acromegaly / Q000601:surgery*; D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000009:adverse effects / Q000379:methods*; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult