title: Gram-positive antimicrobial activity of amino acid-based hydrogels.
abstract: Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
authors.forename: I
authors.initials: I
authors.lastname: Irwansyah
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Li
authors.forename: Wenxiong
authors.initials: W
authors.lastname: Shi
authors.forename: Dianpeng
authors.initials: D
authors.lastname: Qi
authors.forename: Wan Ru
authors.initials: WR
authors.lastname: Leow
authors.forename: Mark B Y
authors.initials: MB
authors.lastname: Tang
authors.forename: Shuzhou
authors.initials: S
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D005449:Fluorenes / Q000737:chemistry; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D020100:Hydrogels / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D000596:Amino Acids; D000900:Anti-Bacterial Agents; D005449:Fluorenes; D020100:Hydrogels
keywords: Fmoc-amino acids; antimicrobial hydrogels; biocompatible; co-assembly; gram-positive bacteria