title: Development and optimization of modified release IPN macromolecules of oxcarbazepine using natural polymers.
abstract: The study shows development and optimization of modified release interpenetrating polymer network (IPN) macromolecules (beads) of oxcarbazepine using sodium alginate-egg albumin prepared by ionotropic gelation method and CaCl2 as a cross-linker. Independent variables were identified based on preliminary study of investigation. The effect of amount of both polymers on drug entrapment efficiency (DEE,%), bead size (μm) and cumulative drug release at 8 h (Q8h, %) were optimized using 3(2) factorial design. The DEE, average size and Q8h were found in the range of 65.08-91.02%, 976-1084 μm and 73.50-94.06% respectively. The beads were also characterized by FTIR, DSC, SEM and XRD. The experiential responses were coincided well with predicted values obtained by Design-Expert(®) 8.0.6.1 software. The swelling of beads were influenced by the pH of a release medium. The in vitro drug release from IPN beads exhibited sustained release Hixson-Crowell pattern with anomalous non-Fickian diffusion mechanism concluding that the developed sodium alginate-egg albumin IPN composite beads are suitable for sustained delivery of oxcarbazepine for desired period.
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India. Electronic address: vippra2000@yahoo.com.
authors.forename: Vipul D
authors.initials: VD
authors.lastname: Prajapati
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India.
authors.forename: Abhishek K
authors.initials: AK
authors.lastname: Gandhi
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India.
authors.forename: Krishna K
authors.initials: KK
authors.lastname: Patel
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India.
authors.forename: Bhumit N
authors.initials: BN
authors.lastname: Patel
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India.
authors.forename: Anita M
authors.initials: AM
authors.lastname: Chaudhari
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, U.T. of Dadra and Nagar Haveli-396230, India.
authors.forename: Girish K
authors.initials: GK
authors.lastname: Jani
mesh_terms: D000464:Alginates / Q000737:chemistry; D000704:Analysis of Variance; D002220:Carbamazepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007700:Kinetics; D008863:Microspheres; D010047:Ovalbumin / Q000737:chemistry; D000078330:Oxcarbazepine; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D011108:Polymers; D002220:Carbamazepine; D020723:Glucuronic Acid; D010047:Ovalbumin; D000078330:Oxcarbazepine
keywords: Egg albumin; Oxcarbazepine; Sodium alginate