title: Prostate cancer antigen 3 as a biomarker in the urine for prostate cancer diagnosis: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to investigate the clinical value of urine Prostate cancer antigen 3 (PCA3) test in the diagnosis of prostate cancer by pooling the published data.
  
  
  METHODS
  The clinical trials about urine PCA3 test in the diagnosis of prostate cancer were searched in the PubMed (January, 1966-July, 2014). Cochrane library (Section 3, 2013), CNKI (March, 1994-July, 2014). All relevant prospective studies of urine PCA3 test in the diagnosis of prostate cancer were screened. The aggregated sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnosis odds ratio (DOR) and area under the area under curve (AUC) were calculated by using Meta-disc 1.4 and STATA 11.0 statistic software.
  
  
  RESULTS
  Finally, a total of 13 trials including 3245 subjects were included in this meta-analysis. The pooled sensitivity, specificity, +LR, -LR, DOR and AUC were 0.62 (95% confidence interval [CI]: 0.59-0.65), 0.75 (95% CI: 0.73-0.76), 6.16 (95% CI: 3.39-11.21), 0.50 (95% CI: 0.43-0.59), 5.49 (95% CI: 3.76-8.019) and 0.75 (95% CI: 0.71-0.78), respectively.
  
  
  CONCLUSIONS
  Urine PCA3 test has acceptable sensitivity and specificity in the diagnosis of prostate cancer, which can be used as non-invasive method for diagnosis of prostate cancer.
authors.forename: Wu-Jin
authors.initials: WJ
authors.lastname: Xue
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Ying
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Jiang
authors.affiliation: Department of Hematology, The People's Hospital of Lishui City, Zhejiang Province, 323000, China.
authors.forename: Ye-Hui
authors.initials: YH
authors.lastname: Xu
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000652:urine*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000652:urine*; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C479341:prostate cancer antigen 3, human