title: Reduced rotavirus vaccine effectiveness among children born during the rotavirus season: a pooled analysis of 5 case-control studies from the Americas.
abstract: Using data from rotavirus vaccine effectiveness (VE) studies, we assessed whether rotavirus season modifies rotavirus VE in infants. In the first year of life, adjusted VE was 72% for children born during rotavirus season and 84% for children born in other months (P = .01). Seasonal factors may interfere with vaccine performance.
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Prasanna S
authors.initials: PS
authors.lastname: Premkumar
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gastanaduy
authors.affiliation: Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City.
authors.forename: John P
authors.initials: JP
authors.lastname: McCracken
authors.affiliation: Pan American Health Organization, Washington, District of Columbia.
authors.forename: Lucia Helena
authors.initials: LH
authors.lastname: de Oliveira
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Payne
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Ben A
authors.initials: BA
authors.lastname: Lopman
mesh_terms: D000569:Americas; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D022243:Rotavirus Vaccines
keywords: birth seasons; pooled analysis; rotavirus disease; rotavirus vaccines