title: Serum levels of the adipokine Pref-1 in gestational diabetes mellitus.
abstract: OBJECTIVE
  Pref-1 has recently been introduced as a novel insulin resistance-inducing adipokine influencing adipogenesis. The role of circulating Pref-1 in patients with gestational diabetes mellitus (GDM) has not been assessed so far.
  
  
  METHODS
  We determined circulating Pref-1 serum levels in 74 patients with GDM, as well as 74 healthy age-, body mass index (BMI-), and gestational age-matched pregnant controls. Furthermore, Pref-1 was correlated with anthropometric measures, as well as biochemical markers, of glucose homeostasis, lipid metabolism, renal function, and inflammation.
  
  
  RESULTS
  Mean serum Pref-1 levels during pregnancy were not significantly different between patients with GDM (0.40μg/l) and healthy controls (0.42μg/l) (p=0.655). Multivariate analysis revealed that gestational age at blood sampling, triglycerides (TG), and creatinine independently and positively predicted Pref-1 levels (p<0.05). Furthermore, Pref-1 levels were independently and negatively associated with BMI and C reactive protein (p<0.05).
  
  
  CONCLUSIONS
  Pref-1 is probably not a major contributor to GDM pathophysiology but might directly contribute to TG metabolism, as well as depend on gestational age and renal function.
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address: ulrike.wurst@medizin.uni-leipzig.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Wurst
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebert
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002135:Calcium-Binding Proteins; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008565:Membrane Proteins / Q000097:blood*; D015999:Multivariate Analysis; D011247:Pregnancy; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C512941:DLK1 protein, human; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D003404:Creatinine
keywords: Adipocytes; Gestational diabetes mellitus; Pref-1; Pregnancy