title: Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery.
abstract: Novel multifunctional porous titanium dioxide (TiO2) nanoparticles modified with polyethylenimine (PEI) were developed to explore the feasibility of exploiting the photocatalytic property of titanium dioxide to achieve ultraviolet (UV) light triggered drug release. Additionally, in order to further realize targeting delivery, folic acid, which chemically conjugated to the surface of the functionalized multifunctional porous TiO2 nanoparticles through amide linkage with free amine groups of PEI, was used as a cancer-targeting agent to effectively promote cancer-cell-specific uptake through receptor-mediated endocytosis. And a typical poorly water-soluble anti-cancer drug, paclitaxel, was encapsulated in multifunctional porous TiO2 nanoparticles. The PEI on the surface of multifunctional porous TiO2 nanoparticles could effectively block the channel to prevent premature drug release, thus providing enough circulation time to target cancer cells. Following UV light radiation, PEI molecules on the surface were cut off by the free radicals (OH˙ and O2-) that TiO2 produced, and then the drug loaded in the carrier was released rapidly into the cytoplasm. Importantly, the amount of drug released from multifunctional porous TiO2 nanoparticles can be regulated by the UV-light radiation time to further control the anti-cancer effect. This multifunctional porous TiO2 nanoparticle exhibits a combination of stimuli-triggered drug release and cancer cell targeting. The authors believe that the present study will provide important information for the use of porous TiO2 nanomaterials in light-controlled drug release and targeted therapy.
authors.affiliation: College of Life Science and Health, Northeastern University, 89 Wenhuadong Road, Shenhe District, Shenyang, Liaoning Province 110015, People's Republic of China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, People's Republic of China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, People's Republic of China.
authors.forename: Long
authors.initials: L
authors.lastname: Wan
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, People's Republic of China.
authors.forename: Qinfu
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, People's Republic of China.
authors.forename: Tongying
authors.initials: T
authors.lastname: Jiang
authors.affiliation: College of Life Science and Health, Northeastern University, 89 Wenhuadong Road, Shenhe District, Shenyang, Liaoning Province 110015, People's Republic of China. Electronic address: wangbing@mail.neu.edu.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, People's Republic of China. Electronic address: silingwang@syphu.edu.cn.
authors.forename: Siling
authors.initials: S
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D011094:Polyethyleneimine / Q000737:chemistry; D016062:Porosity; D014025:Titanium / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C009495:titanium dioxide; D011094:Polyethyleneimine; D005492:Folic Acid; D014025:Titanium; D017239:Paclitaxel
keywords: Controllable release; Nanoparticle; Porous TiO(2); Surface functionalization; Targeting