title: Evaluation of computed tomography-guided parapharyngeal mass needle biopsy through mandibular notch for diagnosis of recurrent nasopharygeal carcinoma.
abstract: OBJECTIVE
  The aim was to evaluate the effectiveness of computed tomography (CT)-guided fine-needle aspiration biopsy (FNAB) from Mandibular notch and under the zygomatic arch for pathological diagnosis of recurrence nasopharyngeal carcinoma (NPC) after radiotherapy (RT).
  
  
  METHODS
  Between October 2007 and December 2013, 48 patients with suspected recurrent NPC underwent CT-guided FNAB. A modified coaxial technique was used in all cases, and multiple samples were obtained for histological studies.
  
  
  RESULTS
  We obtained a definite histological diagnosis with 87.5% (42/48) overall diagnostic accuracy. In 42 patients the needle aspirate confirmed a clinical suspicion of recurrent disease and the histologic finding was positive (10 cases of squamous cell carcinoma, 3 cases of adenocarcinoma, finding tumor cells tend to squamous cell carcinoma in 24 patients and undifferentiated carcinoma in 5 patients). In the six cases of "no tumor seen" confirmation was made by clinical and imaging follow-up showing 2 tumor relapse and 4 fibrillation.
  
  
  CONCLUSIONS
  CT-guided FNAB from Mandibular notch and under the zygomatic arch is a safe and accurate technique useful for pathological diagnosis of recurrence NPC after RT.
authors.forename: Liming
authors.initials: L
authors.lastname: Jiang
authors.forename: Haimiao
authors.initials: H
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.forename: Lirong
authors.initials: L
authors.lastname: Tang
authors.forename: Tiemin
authors.initials: T
authors.lastname: Xie
authors.forename: Xing
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Oncology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002277:Carcinoma; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods