title: Stability studies of As4S4 nanosuspension prepared by wet milling in Poloxamer 407.
abstract: In this paper the stability of the arsenic sulfide (As4S4) nanosuspension prepared by wet milling in a circulation mill in the environment of copolymer Poloxamer 407 was studied. The obtained As4S4 particles in nanosuspension were of ∼ 100 nm in size. The influence of temperature and UV irradiation on the changes in physical and/or chemical properties was followed. Long-term stability was observed via particle size distribution and zeta potential measurements. Influence of UV irradiation was studied via UV-vis spectroscopy (UV-vis), photoluminicsence (PL) technique and Fourier transform infrared spectroscopy (FTIR) measurements. The best stability of the nanosuspension (24 weeks) was achieved when stored at 4°C and in the dark.
authors.affiliation: Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Košice 040 01, Slovakia. Electronic address: bujnakova@saske.sk.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Bujňáková
authors.affiliation: Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Košice 040 01, Slovakia.
authors.forename: Erika
authors.initials: E
authors.lastname: Dutková
authors.affiliation: Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Košice 040 01, Slovakia.
authors.forename: Matej
authors.initials: M
authors.lastname: Baláž
authors.affiliation: Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Košice 040 01, Slovakia.
authors.forename: Erika
authors.initials: E
authors.lastname: Turianicová
authors.affiliation: Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Košice 040 01, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Baláž
mesh_terms: D001152:Arsenicals / Q000737:chemistry* / Q000528:radiation effects; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry* / Q000528:radiation effects; D013535:Suspensions; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D001152:Arsenicals; D013440:Sulfides; D013535:Suspensions; D020442:Poloxamer
keywords: Arsenic sulfide; Nanomilling; Nanosuspension; Particle size; Stability