title: The role of glia in stress: polyamines and brain disorders.
abstract: This review focuses on the roles of glia and polyamines (PAs) in brain function and dysfunction, highlighting how PAs are one of the principal differences between glia and neurons. The novel role of PAs, such as putrescine, spermidine, and spermine and their precursors and derivatives, is discussed. However, PAs have not yet been a focus of much glial research. They affect many neuronal and glial receptors, channels, and transporters. They are therefore key elements in the development of many diseases and syndromes, thus forming the rationale for PA-focused and glia-focused therapy for these conditions.
authors.affiliation: Department of Biochemistry, School of Medicine, Universidad, Central del Caribe, PO Box 60-327, Bayamón, PR 00960-6032, USA; Department of Physiology, School of Medicine, Universidad, Central del Caribe, PO Box 60-327, Bayamón, PR 00960-6032, USA. Electronic address: sergueis50@yahoo.com.
authors.forename: Serguei N
authors.initials: SN
authors.lastname: Skatchkov
authors.affiliation: Department of Psychiatry, University of Puerto Rico School of Medicine, 307 Calle Eleonor Roosevelt, San Juan, PR 00918-2720, USA.
authors.forename: Michel A
authors.initials: MA
authors.lastname: Woodbury-Fariña
authors.affiliation: Department of Biochemistry, School of Medicine, Universidad, Central del Caribe, PO Box 60-327, Bayamón, PR 00960-6032, USA.
authors.forename: Misty
authors.initials: M
authors.lastname: Eaton
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000378:metabolism*; D006801:Humans; D009457:Neuroglia / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D011073:Polyamines
keywords: Brain disorders; Glia; Polyamines; Stress