title: A longer life for yeast with good memory.
abstract: Cell polarity establishment has been studied in great detail, but much less is known about mechanisms that prevent polarization. Reporting recently in Cell, Meitinger et al. (2014) identify an elaborate mechanism in yeast cells that efficiently inhibits Cdc42 activation in cytokinesis remnants. Failure of this "anti-polarization" memory increases replicative aging.
authors.affiliation: Institute of Cell Dynamics and Imaging and Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Muenster, Von Esmarchstrasse 56, 48149 Muenster, Germany. Electronic address: wedlich@uni-muenster.de.
authors.forename: Roland
authors.initials: R
authors.lastname: Wedlich-Söldner
mesh_terms: D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae