title: The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease.
abstract: Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection. Recent human microbiome studies suggest that the gut microbiome composition is differentiated in carriers of many risk variants of major CD susceptibility genes. This interplay between host genetics and its associated gut microbiome may play an essential role in the pathogenesis of CD. The ongoing microbiome research is aimed to investigate the detailed host genetics-microbiome interacting mechanism.
authors.affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 14-70 Icahn Building, New York, NY 10029, USA. Electronic address: Jianzhong.hu@mssm.edu.
authors.forename: Hu
authors.initials: H
authors.lastname: Jianzhong
mesh_terms: D001343:Autophagy / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D064307:Microbiota
keywords: Crohn disease; Gut microbiome; Host genetics