title: Effective treatment of d-penicillamine induced elastosis perforans serpiginosa with ALA-PDT.
abstract: A case of D-penicillamine(DPA) induced elastosis perforans serpiginosa(EPS) in a 32-year-old Chinese man was reported. The presentation lasted two years and was refractory to traditional medical treatment. He was then commenced on 7.6% 5-aminolevulinic acid (ALA) induced photodynamic therapy(PDT) by a LED light of 633 nm at dose levels of 130J/ cm2 for each session with total 3 sessions at one week interval. The patient was tolerated and responded well to this new approach for DPA-induced EPS without any adverse events. The etiology, pathophysiology, natural history, and treatment options for DPA-induced EPS are reviewed, and the authors suggest this method of treatment to be effective and safe for patients of DPA-induced EPS refractory to conventional therapy.
authors.affiliation: Fudan University, Huashan Hospital, Department of Dermatology, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, People's Republic of China.
authors.forename: Duoqin
authors.initials: D
authors.lastname: Wang
authors.affiliation: Fudan University, Huashan Hospital, Department of Dermatology, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Fudan University, Huashan Hospital, Department of Dermatology, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, People's Republic of China; District Central Hospital of Shanghai, Department of Dermatology, 256 Xikang Road, Jing'an District, Shanghai 200040, People's republic of China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: Fudan University, Huashan Hospital, Department of Dermatology, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, People's Republic of China. Electronic address: hschenlianjun@163.com.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011537:Pruritus / Q000150:complications / Q000188:drug therapy; D012871:Skin Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D002614:Chelating Agents; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; D010396:Penicillamine
keywords: 5-Aminolevulinic acid; Elastosis perforans serpiginosa; Photodynamic therapy; d-Penicillamine