title: Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral cancer.
abstract: Detecting bone invasion in oral cancer is crucial for therapy planning and the prognosis. The present study evaluated cone beam computed tomography (CBCT) for detecting bone invasion in comparison to standard imaging techniques. A total of 197 patients with diagnoses of oral cancer underwent CBCT as part of preoperative staging between January 2007 and April 2013. The sensitivity, specificity, and accuracy of CBCT were compared with panoramic radiography (PR), multi-slice computed tomography (CT) or magnetic resonance imaging (MRI), and bone scintigraphy (BS) using McNemar's test. Histopathology and clinical follow-up served as references for the presence of bone invasion. CBCT and BS (84.8% and 89.3%, respectively), as well as CBCT and CT/MRI (83.2%), showed comparable accuracy (P = 0.188 and P = 0.771). CBCT was significantly superior to PR, which was reconstructed based on a CBCT dataset (74.1%, P = 0.002). In detecting bone invasion, CBCT was significantly more accurate than PR and was comparable to BS and CT/MRI. However, each method has certain advantages, and the best combination of imaging methods must be evaluated in prospective clinic trials.
authors.affiliation: Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Würzburg, Germany. Electronic address: Linz_c@ukw.de.
authors.forename: C
authors.initials: C
authors.lastname: Linz
authors.affiliation: Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: U D A
authors.initials: UD
authors.lastname: Müller-Richter
authors.affiliation: Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: A K
authors.initials: AK
authors.lastname: Buck
authors.affiliation: Institute of Pathology, University of Würzburg, Würzburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Mottok
authors.affiliation: Department of Radiology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Ritter
authors.affiliation: Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.affiliation: Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Metzen
authors.affiliation: Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Centre, University of Würzburg, Würzburg, Germany; Clinical Trial Centre Würzburg, University Hospital Würzburg, Würzburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Heuschmann
authors.affiliation: Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Clinical Trial Centre Würzburg, University Hospital Würzburg, Würzburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Malzahn
authors.affiliation: Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: A C
authors.initials: AC
authors.lastname: Kübler
authors.affiliation: Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Herrmann
authors.affiliation: Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Bluemel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054893:Cone-Beam Computed Tomography; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging; D011862:Radiography, Panoramic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012888:Skull Neoplasms / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
keywords: bone scintigraphy; cone beam computed tomography; magnetic resonance imaging; oral cancer; panoramic radiography