title: Chronic unpredictable stress during adolescence causes long-term anxiety.
abstract: Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.
authors.affiliation: Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Ecosystem Science & Management, Pennsylvania State University, University Park, PA 16802, United States; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, United States. Electronic address: Chaby@psu.edu.
authors.forename: L E
authors.initials: LE
authors.lastname: Chaby
authors.affiliation: Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, United States; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: S A
authors.initials: SA
authors.lastname: Cavigelli
authors.affiliation: Department of Biology, Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: A M
authors.initials: AM
authors.lastname: Hirrlinger
authors.affiliation: Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: M J
authors.initials: MJ
authors.lastname: Caruso
authors.affiliation: Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Ecosystem Science & Management, Pennsylvania State University, University Park, PA 16802, United States; Department of Biology, Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: V A
authors.initials: VA
authors.lastname: Braithwaite
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000367:Age Factors; D000818:Animals; D001007:Anxiety / Q000209:etiology*; D003071:Cognition; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012201:Reward; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Adolescence; Anxiety; Chronic unpredictable stress; Corticosterone; Novelty suppressed feeding; Rattus norvegicus