title: Adeno-associated virus-mediated cancer gene therapy: current status.
abstract: Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowledge on AAV-mediated cancer gene therapy.
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Nephrology, Zhuji People's Hospital, Zhuji, Zhejiang, China.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China; Image-Guided Bio-Molecular Intervention Research, Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: xmyang@uw.edu.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D052138:Genes, Neoplasm; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*
keywords: Adeno-associated virus; Cancer; Cancer gene therapy; Gene vehicle