title: Topical curcumin-loaded hydrogels obtained using galactomannan from Schizolobium parahybae and xanthan.
abstract: The curcumin (CUR)-loaded binary hydrogel was formulated using xanthan and galactomannan from Schizolobium parahybae (guapuruvu). The binary hydrogels presented gel characteristics, stable pH values and mechanical stress resistance even after 45 days of heat exposure (45 °C). The CUR-loaded hydrogel content was 98.6% for XGMC (xanthan and galactomannan with CUR-microemulsion) after the stability test. The in vitro cytotoxicity analysis suggested non-cutaneous membrane irritation, and the in vitro skin permeation analysis indicated 2.15 to 2.50 μg mL(-1) CUR at the stratum corneum, epidermal and dermal levels. The XGEC (xanthan and galactomannan with CUR solubilized in ethanol) and XGMC hydrogels presented 76.8 and 63.2% inhibition of topical inflammation, respectively. Chemical stability and non-cytotoxicity analysis confirm the safety of prolonged exposure of the skin during the topical treatment, offering long-lasting XGEC and XGMC action.
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
authors.forename: Heidegrid Siebert
authors.initials: HS
authors.lastname: Koop
authors.affiliation: Department of Chemistry, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
authors.forename: Rilton Alves
authors.initials: RA
authors.lastname: de Freitas
authors.affiliation: Postgraduate Program at Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Brazil.
authors.forename: Márcia Maria
authors.initials: MM
authors.lastname: de Souza
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Savi
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil. Electronic address: jlms12@yahoo.com.
authors.forename: Joana Léa Meira
authors.initials: JL
authors.lastname: Silveira
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003436:Croton Oil; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D065546:Drug Liberation; D004355:Drug Stability; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004655:Emulsions; D007887:Fabaceae / Q000737:chemistry*; D005690:Galactose / Q000031:analogs & derivatives; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012869:Skin Absorption; D013314:Stress, Mechanical; D013552:Swine; D014945:Wound Healing
chemical_list: D000893:Anti-Inflammatory Agents; D004655:Emulsions; D020100:Hydrogels; D008351:Mannans; D011135:Polysaccharides, Bacterial; C012990:galactomannan; D003436:Croton Oil; D003474:Curcumin; C002563:xanthan gum; D005690:Galactose
keywords: Curcumin; Galactomannan; In-vitro skin permeation; Microemulsion; Polysaccharide hydrogel; Xanthan