title: Synthesis, structural, optical and anti-rheumatic activity of metal complexes derived from (E)-2-amino-N-(1-(2-aminophenyl)ethylidene)benzohydrazide (2-AAB) with Ru(III), Pd(II) and Zr(IV).
abstract: Three new metal complexes derived from Pd(II), Ru(III) and Zr(IV) with (E)-2-amino-N-(1-(2-aminophenyl)ethylidene)benzohydrazide (2-AAB) have been synthesized. The isolated complexes were characterized by elemental analyses, FT-IR, UV-Vis, ES-MS, (1)H NMR, XRD, thermal analyses (TGA and DTA) and conductance. The morphology and the particle size were determined by transmittance electron microscope (TEM). The results showed that, the ligand coordinates to Pd(II) in the enol form, while it coordinates to Ru(III) and Zr(IV) in the keto form. A square planar geometry is suggested for Pd(II) complex and octahedral geometries are suggested for Ru(III) and Zr(IV) complexes. The optical band gaps of the isolated complexes were measured and indicated the semi-conductivity nature of the complexes. The anti-inflammatory and analgesic activities of the ligand and its complexes showed that, Ru(III) complex has higher effect than the well known drug "meloxicam".
authors.affiliation: Chemistry Department, Faculty of Science, Port-Said University, 23 December Street, Port-Said, Egypt. Electronic address: Nasserh56@yahoo.com.
authors.forename: Nasser Mohammed
authors.initials: NM
authors.lastname: Hosny
authors.affiliation: Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Saudi Arabia; Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Yousery E
authors.initials: YE
authors.lastname: Sherif
mesh_terms: D000586:Amination; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D035002:Lower Extremity / Q000473:pathology; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry* / Q000627:therapeutic use; D017207:Rats, Sprague-Dawley; D012428:Ruthenium / Q000737:chemistry* / Q000627:therapeutic use; D015040:Zirconium / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D001555:Benzene Derivatives; D056831:Coordination Complexes; D006834:Hydrazines; D010165:Palladium; D012428:Ruthenium; D015040:Zirconium
keywords: Anti-inflammatory activity; Metal complexes; Pd(II); Ru(III); Zr(IV)