title: Module number of default mode network: inter-subject variability and effects of sleep deprivation.
abstract: Sleep deprivation have shown its great influence on the default mode network (DMN). The DMN is a core system in resting state brain activity. Recent studies have focused on its subsystems and multiple functions. However, the individual specific organization of the DMN is rarely investigated. As the effects of sleep deprivation (SD) on mood are well documented, a more interesting question is whether changes in the processing of emotional information due to sleep deprivation are related to any specific topological properties of the DMN. In this study, we proposed an index, module number of DMN (mnDMN), to measure the specific modular structure of the DMN for each individual. Our results showed that the DMN was generally split into two modules after SD, and the decreased functional connectivity between the two modules was related to a worsening of the participants׳ self-reported emotional state. Furthermore, the mnDMN was correlated with participants' rating scores of high valence pictures in the SD session, indicating that the mnDMN might reflect mood valuation in the human brain. Overall, our research reveals the diversity of the DMN, and may contribute towards a better understanding of the properties and functions of the DMN.
authors.affiliation: Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China; Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China; Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
authors.forename: Glenn
authors.initials: G
authors.lastname: Hitchman
authors.affiliation: Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China; Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China. Electronic address: xlei@swu.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Lei
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000098:blood supply / Q000473:pathology*; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D012892:Sleep Deprivation / Q000473:pathology*
chemical_list: D010100:Oxygen
keywords: Default mode network; Functional connectivity; Modularity; Sleep deprivation