title: Intergenerational transmission of fronto-parietal dysfunction during forethought in attention deficit/hyperactivity disorder: a pilot study.
abstract: There are only a few published reports of neural abnormalities within the families of children with attention deficit/hyperactivity disorder (ADHD). Functional magnetic resonance imaging was used to compare cerebral activation of ADHD and control biological parent-child dyads during forethought, a prospective function of working memory. Reduced activations in ADHD dyads were found in the inferior frontal gyrus, right superior parietal lobule and left inferior parietal lobule. This suggests that fronto-parietal abnormalities are shared within ADHD families.
authors.affiliation: Education and Pedagogy Department, Université du Québec à Montréal, Quebec, Canada. Electronic address: poissant.helene@uqam.com.
authors.forename: Hélène
authors.initials: H
authors.lastname: Poissant
authors.affiliation: Linguistics Department, Université du Québec à Montréal, Montréal, Quebec, Canada.
authors.forename: Lucile
authors.initials: L
authors.lastname: Rapin
authors.affiliation: Psychology Department, Bishop׳s University, Sherbrooke, Quebec, Canada.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mendrek
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics / Q000503:physiopathology*; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D010290:Parents / Q000523:psychology*; D010296:Parietal Lobe / Q000503:physiopathology*; D010865:Pilot Projects
keywords: ADHD; Heritability; fMRI