title: Design, synthesis, anti-TMV, fungicidal, and insecticidal activity evaluation of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid derivatives based on virus inhibitors of plant sources.
abstract: By drawing the creation ideas of botanical pesticides, a series of tetrahydro-β-carboline-3-carboxylic acid derivatives were designed and synthesized, and first evaluated for their anti-TMV, fungicidal and insecticidal activities. Most of these derivatives exhibited good antiviral activity against TMV both in vitro and in vivo. Especially, the activities of compounds 8 and 15 in vivo were higher than that of ribavirin. The compound 8 exhibited more than 70% fungicidal activities against Cercospora arachidicola Hori, Alternaria solani, Bipolaris maydis, and Rhizoctonia solani at 50mg/kg, compounds 16 and 20 exhibited more than 60% insecticidal activities against Mythimna separate and Ostrinia nubilalis.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Hong-jian
authors.initials: HJ
authors.lastname: Song
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Yong-xian
authors.initials: YX
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Yu-xiu
authors.initials: YX
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Yuan-qiong
authors.initials: YQ
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Yong-qiang
authors.initials: YQ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China. Electronic address: wang98h@263.net.
authors.forename: Qing-min
authors.initials: QM
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002243:Carbolines / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D032443:Peganum; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D002243:Carbolines; D005659:Fungicides, Industrial; D007306:Insecticides; D010936:Plant Extracts; C054910:1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
keywords: Anti-TMV; Fungicide; Insecticide; Plant derived pesticides; β-Carboline