title: E-cadherin, guardian of liver physiology.
abstract: E-cadherin is a cell-to-cell adhesion molecule involved in epithelial cell behavior, tissue formation and cancer suppression. In the liver, E-cadherin is expressed by hepatocytes and biliary epithelial cells. However, the exact role of E-cadherin in hepatic pathophysiology remains largely unknown. Recently, specific loss of E-cadherin in liver epithelial cells has been shown to favor periportal fibrosis, periportal inflammation and liver cancer progression, suggesting that E-cadherin is a central liver protector.
authors.affiliation: Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France.
authors.forename: Ester
authors.initials: E
authors.lastname: Gonzalez-Sanchez
authors.affiliation: Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France.
authors.forename: Javier
authors.initials: J
authors.lastname: Vaquero
authors.affiliation: Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Fouassier
authors.affiliation: Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France. Electronic address: nicolas.chignard@upmc.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chignard
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D063646:Carcinogenesis; D015209:Cholangitis, Sclerosing / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male
chemical_list: D015820:Cadherins