title: The correlation between mid-brain serotonin transporter availability and intelligence quotient in healthy volunteers.
abstract: OBJECTIVE
  This study was performed to investigate the association between the mid-brain serotonin transporter (SERT) availability and intelligence quotient (IQ).
  
  
  METHODS
  One hundred and thirteen healthy participants, including 52 male and 61 female subjects, were recruited. We used SPECT with [(123)I]ADAM images to determine the SERT availability in the mid-brain, and measured the subjects' IQ using the WAIS-R.
  
  
  RESULTS
  We found a significant positive correlation between the mid-brain SERT availability and the IQ of the participants. Even when controlling for age and sex, the significant association still existed.
  
  
  CONCLUSIONS
  This result implied that the higher the SERT binding in the mid-brain, the better the IQ in healthy participants.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: P Y
authors.initials: PY
authors.lastname: Tseng
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: I H
authors.initials: IH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan.
authors.forename: K C
authors.initials: KC
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan.
authors.forename: P S
authors.initials: PS
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: N T
authors.initials: NT
authors.lastname: Chiu
authors.affiliation: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: W J
authors.initials: WJ
authors.lastname: Yao
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: C L
authors.initials: CL
authors.lastname: Chu
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
authors.forename: T L
authors.initials: TL
authors.lastname: Yeh
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan. Electronic address: ykyang@mail.ncku.edu.tw.
authors.forename: Y K
authors.initials: YK
authors.lastname: Yang
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007360:Intelligence; D007457:Iodine Radioisotopes; D008297:Male; D059906:Neuroimaging / Q000379:methods; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Cognitive function; Intelligence quotient; SPECT; Serotonin transporter availability; [(123)I]ADAM