title: Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum.
abstract: This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined with deferasirox. Smaller lesions were observed in infected rabbits receiving the combination therapy, although it favored disease dissemination to the lungs. The present results show that micafungin alone is ineffective against P. insidiosum, and the combination micafungin-deferasirox might have deleterious effects for the host.
authors.affiliation: Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Campus UFSM, Prédio 20, Sala 4139, 97105-900, Santa Maria, RS, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Zanette
authors.affiliation: Graduate Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: F P K
authors.initials: FP
authors.lastname: Jesus
authors.affiliation: Mycologycal Research Laboratory, UFSM, Santa Maria, RS, Brazil.
authors.forename: M B
authors.initials: MB
authors.lastname: Pilotto
authors.affiliation: Mycologycal Research Laboratory, UFSM, Santa Maria, RS, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Weiblen
authors.affiliation: Department of Zootechny, UFSM, Santa Maria, RS, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Pötter
authors.affiliation: Graduate Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Ferreiro
authors.affiliation: Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Campus UFSM, Prédio 20, Sala 4139, 97105-900, Santa Maria, RS, Brazil.
authors.forename: S H
authors.initials: SH
authors.lastname: Alves
authors.affiliation: Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Campus UFSM, Prédio 20, Sala 4139, 97105-900, Santa Maria, RS, Brazil. Electronic address: janio.santurio@gmail.com.
authors.forename: J M
authors.initials: JM
authors.lastname: Santurio
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage; D001565:Benzoates / Q000008:administration & dosage*; D000077588:Deferasirox; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy / Q000382:microbiology; D006736:Horses; D055666:Lipopeptides / Q000008:administration & dosage*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D058968:Pythiosis / Q000188:drug therapy* / Q000382:microbiology; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D011817:Rabbits; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D001565:Benzoates; D054714:Echinocandins; D055666:Lipopeptides; D014230:Triazoles; D000077551:Micafungin; D000077588:Deferasirox
keywords: Chélateur du fer; Echinocandin; Iron chelator; Oomycete; Oomycète; Sensibilité; Susceptibility; Échinocandine