title: Potential treatment of inflammatory bowel disease: a review of helminths therapy.
abstract: An inflammatory bowel disease (IBD) is most common in highly industrialized Western countries but uncommon in less developed areas of the world where helminths are frequent. The hygiene hypothesis proposes that the recent increase in allergic and autoimmune diseases is due to modern highly hygienic life styles and medical conditions. Loss of routine exposure to parasitic helminths, as a result of increasing lifestyle-associated factors, may be one factor leading to the increased disease prevalence. In animal models and clinical trials of IBD, gastrointestinal nematodes colonization suppresses intestinal inflammation through multiple mechanisms including induction of innate and adaptive regulatory circuits. Studies using helminths like Trichuris suis or Necator americanus showed that these helminths are safe and may be effective therapeutic approaches for the control of IBD and other immune diseases. The aim of present review was to exploring the therapeutic use of helminths for the control of IBD.
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Department of Medical Parasitology & Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Taghipour
authors.affiliation: Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Asadzadeh
authors.initials: HA
authors.lastname: Aghdaei
authors.affiliation: Department of Medical Parasitology & Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Haghighi
authors.affiliation: Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nariman
authors.initials: N
authors.lastname: Mossafa
authors.affiliation: Department of Medical Parasitology & Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Seyyed Javad Seyyed
authors.initials: SJ
authors.lastname: Tabaei
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rostami-Nejad
keywords: Helminthes; Inflammatory bowel disease; Therapeutic