title: Stenotrophomonas maltophilia with histopathological features mimicking cutaneous gamma/delta T-cell lymphoma.
abstract: We report a case of cutaneous Stenotrophomonas maltophilia infection which presented with clinical and histopathological findings that mimicked a gamma/delta (γδ) T-cell lymphoma. In this case, tissue culture of the biopsy specimen was key to determining the diagnosis and allowing appropriate treatment with oral trimethoprim-sulfamethoxazole and topical silvadene. A prompt complete resolution of lesions was observed following antibiotic treatment, with no recurrence of disease over the last 5 years, supporting an infectious rather than malignant etiology. In our patient, radiation therapy was indicated based on the misdiagnosis of γδ T-cell lymphoma, which was supported both clinically and histopathologically. However, tissue culture in this case avoided unnecessary radiation exposure and highlights the role of tissue culture in the evaluation of the biopsy of an undiagnosed cutaneous lesion.
authors.affiliation: Department of Dermatology, The University of Texas Medical School at Houston and MD Anderson Cancer Center, 1400 Pressler Street Unit 1452, Houston, TX 77030, USA. Electronic address: Natalie.N.Kash@uth.tmc.edu.
authors.forename: Natalie
authors.initials: N
authors.lastname: Kash
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Harina
authors.initials: H
authors.lastname: Vin
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Danialan
authors.affiliation: Department of Dermatology, The University of Texas Medical School at Houston and MD Anderson Cancer Center, 1400 Pressler Street Unit 1452, Houston, TX 77030, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.affiliation: Department of Dermatology, The University of Texas Medical School at Houston and MD Anderson Cancer Center, 1400 Pressler Street Unit 1452, Houston, TX 77030, USA.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology; D020615:Stenotrophomonas maltophilia / Q000302:isolation & purification*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Cutaneous T-cell lymphoma; Pseudolymphoma; Stenotrophomonas maltophilia; Xanthomonas maltophilia; γδ T-cell; γδ T-cell lymphoma