title: Use of CT perfusion to discriminate between brain metastases from different primaries.
abstract: Thirty-six metastases in 22 patients were studied prospectively using computed tomography perfusion. Regions of interests were drawn around: the enhancing part of the tumor, necrotic central part, periphery, peritumoral edema, and normal white matter. Cerebral blood volume, cerebral blood flow, and mean transit time were calculated for each zone. The enhancing part of the tumor significantly differed from the other zones in 11 of 12. Metastases of different primaries can be differentiated from one another with statistically significance (P<.05) by at least one perfusion parameter in 57% of cases.
authors.affiliation: Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia.
authors.forename: Mikhail B
authors.initials: MB
authors.lastname: Dolgushin
authors.affiliation: Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia.
authors.forename: Igor N
authors.initials: IN
authors.lastname: Pronin
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Holodny
authors.affiliation: Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia.
authors.forename: Liudmila M
authors.initials: LM
authors.lastname: Fadeeva
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA. Electronic address: holodnya@mskcc.org.
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Holodny
authors.affiliation: Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia.
authors.forename: Valeri N
authors.initials: VN
authors.lastname: Kornienko
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Brain metastases; Brain tumors; CT perfusion; Computed tomography