title: Study on the antibacterial activity of Bergenia purpurascens extract.
abstract: BACKGROUND
  Bergenia purpurascens has tonic, haemostatic and anti-tussive actions. Anti-inflammatory and anti-bacterial activities of Bergenia purpurascens have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of Bergenia purpurascens through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects.
  
  
  METHODS
  Experimental models of xylene-induced ear edema in mice, cotton pellet granuloma in rats, and acetic acid-induced peritoneal capillary permeability in mice were used to investigate the anti-inflammatory effect of Bergenia purpurascens; bacteriostatic and bactericidal effects of Bergenia purpurascens extract on Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), and β-lactamase positive Staphylococcus aureus (ESBLs-SA), were observed in vitro.
  
  
  RESULTS
  The results show that Bergenia purpurascens extract could markedly inhibit xylene-induced mouse ear edema, cotton pellet granulation tissue hyperplasia, and increased capillary permeability. Bergenia purpurascens extract has an inhibitory effect on SA, MRSA and ESBLs-SA.
  
  
  CONCLUSIONS
  We conclude that Bergenia purpurascens extract has certain anti-inflammatory and anti-bacterial effects.
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Shi
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Yingmin
authors.initials: Y
authors.lastname: Han
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Li
authors.affiliation: Pharmacy Department of Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zou
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004487:Edema / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D051379:Mice; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal
keywords: Bergenia purpurascens extract; ESBLs-SA; MRSA; SA; anti inflammation; antibacterial