title: Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1,3,4-oxadiazoles.
abstract: Synthesis of a series of novel N-acylhydrazones of nicotinic acid hydrazides 3a-j via condensation of nicotinic acid hydrazide 1 with the corresponding aldehydes and ketones is described. The series 3a-j was evaluated for in vitro antibacterial activity against two gram negative (Pseudomonas aeruginosa and Klebsiella pneumoniae) and two gram positive (Streptococcus pneumoniae and Staphylococcus aureus) bacteria. The zone of inhibition was measured using the disk diffusion method, and in vitro minimum inhibitory concentration indicating that compounds 3a and 3e were effective against P. aeruginosa with MICs of 0.220 and 0.195 μg respectively.
authors.affiliation: Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine.
authors.forename: Rami Y
authors.initials: RY
authors.lastname: Morjan
authors.affiliation: Chemistry Department, Faculty of Applied Science, Alaqsa University, PO Box 4051, Gaza, Palestine.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Mkadmh
authors.affiliation: Chemistry Department, Manchester Metropolitan University, All Saints Building, All Saints, Manchester M15 6BH, United Kingdom.
authors.forename: Ian
authors.initials: I
authors.lastname: Beadham
authors.affiliation: Medical Technology Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine.
authors.forename: Abdelrauof A
authors.initials: AA
authors.lastname: Elmanama
authors.affiliation: Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine.
authors.forename: Mohammed R
authors.initials: MR
authors.lastname: Mattar
authors.affiliation: School of Chemistry, The University of Manchester, Brunswick Street, Manchester M13 9PL, United Kingdom.
authors.forename: James
authors.initials: J
authors.lastname: Raftery
authors.affiliation: School of Chemistry, The University of Manchester, Brunswick Street, Manchester M13 9PL, United Kingdom.
authors.forename: Robin G
authors.initials: RG
authors.lastname: Pritchard
authors.affiliation: Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine.
authors.forename: Adel M
authors.initials: AM
authors.lastname: Awadallah
authors.affiliation: Manchester Institute of Biotechnology, School of Chemistry and EPS, The University of Manchester, Manchester M1 7DN, United Kingdom.
authors.forename: John M
authors.initials: JM
authors.lastname: Gardiner
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D052978:Disk Diffusion Antimicrobial Tests; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006834:Hydrazines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008968:Molecular Conformation; D009539:Nicotinic Acids / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D006834:Hydrazines; D007659:Ketones; D009539:Nicotinic Acids; D010069:Oxadiazoles; C583463:1,3,4-oxadiazole; C028571:nicotinic acid hydrazide
keywords: 1,3,4-Oxadiazole; Antibacterial; Hydrazides; N-acetyl-1,3,4-oxadiazoles; N-acylhydrazone