title: Altered trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) in the striatum leads to behavioral changes in emotional responses.
abstract: The striatum receives and integrates multiple inputs from diverse areas in the brain and plays a critical role in the regulation of motor activity. However, whether the striatum is involved in the alteration of behavior in the presence of emotional challenges is unknown. Here, we examined whether alterations in the surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) in the dorsal striatum would affect anxiety-related behaviors. We found that the transient expression of G1CT or G2CT, AMPAR-derived peptides, in the dorsomedial striatum led to decreased mobility in high-anxiety circumstances; however, the expression of these peptides in the dorsolateral striatum did not affect anxiety-related behavior. These data suggest that excitatory connections within the dorsomedial striatum play important roles in the control of motor actions in the presence of emotional challenges.
authors.affiliation: Division of Life Sciences, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Division of Life Sciences, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Hojin
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Life Sciences, Sejong University, Seoul 143-747, Republic of Korea.
authors.forename: Hyung-Wook
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Division of Life Sciences, Korea University, Seoul 136-701, Republic of Korea. Electronic address: bjyoon69@korea.ac.kr.
authors.forename: Bong-June
authors.initials: BJ
authors.lastname: Yoon
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000523:psychology; D003342:Corpus Striatum / Q000378:metabolism*; D004644:Emotions; D005822:Genetic Vectors; D008297:Male; D018782:Maze Learning; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D021381:Protein Transport; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D018139:Simplexvirus / Q000235:genetics
chemical_list: D018091:Receptors, AMPA
keywords: AMPA receptor; Emotion; Emotional response; G1CT; G2CT; Striatum