title: Fe-S proteins that regulate gene expression.
abstract: Iron-sulfur (Fe-S) cluster containing proteins that regulate gene expression are present in most organisms. The innate chemistry of their Fe-S cofactors makes these regulatory proteins ideal for sensing environmental signals, such as gases (e.g. O2 and NO), levels of Fe and Fe-S clusters, reactive oxygen species, and redox cycling compounds, to subsequently mediate an adaptive response. Here we review the recent findings that have provided invaluable insight into the mechanism and function of these highly significant Fe-S regulatory proteins. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.
authors.affiliation: University of Wisconsin-Madison, Department of Biomolecular Chemistry, 440 Henry Mall, Biochemical Sciences Building, Room 4204C, Madison, WI 53706, USA. Electronic address: elmettert@wisc.edu.
authors.forename: Erin L
authors.initials: EL
authors.lastname: Mettert
authors.affiliation: University of Wisconsin-Madison, Department of Biomolecular Chemistry, 440 Henry Mall, Biochemical Sciences Building, Room 4204C, Madison, WI 53706, USA. Electronic address: pjkiley@wisc.edu.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Kiley
mesh_terms: D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D020218:Response Elements
chemical_list: D004269:DNA, Bacterial; D007506:Iron-Sulfur Proteins; D007501:Iron
keywords: Gene expression; Iron–sulfur (Fe–S) cluster; Regulatory protein; Sensor; Transcription factor