title: Influence of component 5a receptor 1 (C5AR1) -1330T/G polymorphism on nonsedating H1-antihistamines therapy in Chinese patients with chronic spontaneous urticaria.
abstract: BACKGROUND
  The nonsedating H1-antihistamines are the first-line medicines for chronic spontaneous urticaria (CSU) patients. However, not all these patients respond well to the antihistamines, and the mechanisms underlying the interindividual differences are still unclear. C5AR1 gene encodes the component 5a receptor (C5aR) protein, which has been reported to play an important role in chronic spontaneous urticaria.
  
  
  OBJECTIVE
  This study aimed to investigate whether the single nucleotide polymorphisms (SNPs) in C5AR1 are associated with CSU susceptibility and antihistamines therapeutic efficacy in Chinese CSU patients.
  
  
  METHODS
  A total of 191 CSU patients and 102 healthy controls were prospectively studied in our study. CSU patients were treated by nonsedating H1-antihistamines monotherapy for 4 weeks. The C5AR1 -1330T/G (rs11673309) genotype was determined by Sequenom Massarray.
  
  
  RESULTS
  Among these 191 CSU patients, there were 114 patients who were treated with desloratadine, 65 were treated with mizolastine, and 12 with fexofenadine. The-1330T alleles in CSU patients were significantly higher than controls (0.555 vs. 0.466, P=0.040, OR=1.429 [1.016-2.010]). The poorest response to desloratadine was observed in heterozygotes, when compared with either GG or TT homozgote (P=0.001). However, there was no significant difference in three genotypes when treated with mizolastine group (P=0.215).
  
  
  CONCLUSIONS
  We concluded that the C5AR1 SNP -1330T/G may serve as a useful pharmacodynamic predictor of nonsedating H1-antihistamines efficacy in CSU patients, and -1330T alleles may be taken as a risk factor for the CSU.
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Wangqing
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor PLZ, Houston, TX 77030, United States.
authors.forename: Shu
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Aiyuan
authors.initials: A
authors.lastname: Guo
authors.affiliation: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Jianglin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Yijing
authors.initials: Y
authors.lastname: He
authors.affiliation: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Zhaoqian
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Honghao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Weiqi
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: lijie82@yahoo.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: chenxiangck@gmail.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001562:Benzimidazoles / Q000627:therapeutic use; D016022:Case-Control Studies; D002681:China; D002908:Chronic Disease; D005260:Female; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use*; D006801:Humans; D017336:Loratadine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D044087:Receptor, Anaphylatoxin C5a / Q000235:genetics*; D012307:Risk Factors; D016896:Treatment Outcome; D014581:Urticaria / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D001562:Benzimidazoles; C488033:C5AR1 protein, human; D039563:Histamine H1 Antagonists, Non-Sedating; D044087:Receptor, Anaphylatoxin C5a; C076170:mizolastine; D017336:Loratadine; C121345:desloratadine
keywords: Antihistamines; C5AR1 polymorphism; Chronic spontaneous urticaria; Desloratadine; Mizolastine; UAS7