title: One new ergostane-type steroid and three new phthalide derivatives from cultures of the basidiomycete Albatrellus confluens.
abstract: One new ergostane-type steroid, (12β,15β,22R,23S,24S)-22,25-epoxy-12,15,23-trihydroxyergost-4,6,8(14)-trien-3-one (1), three new phthalide derivatives, 5-(2',3'-epoxy-3',3'-dimethylpropoxy)-7-methoxy-6-methylphthalide (2), (2')-(Z)-5-(3'-hydroxymethyl-3'-methylallyloxy)-7-methoxy-6-methylphthalide (3), and 5-(3',3'-dimethylallyloxy)-7-hydroxy-6-methylphthalide (4), along with one known phthalide derivative, 5-(3',3'-dimethylallyloxy)-7-methoxy-6-methylphthalide (5), were isolated from cultures of the basidiomycete Albatrellus confluens. The structures of the new compounds were established on the basis of extensive spectroscopic data (IR, MS, 1D, and 2D NMR) analyses. All compounds were evaluated for their cytotoxic activities on five tumor cell lines.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: C000598508:(12beta,15beta,22R,23S,24S)-22,25-epoxy-12,15,23-trihydroxyergost-4,6,8(14)-trien-3-one; C000598510:(2')-(Z)-5-(3'-hydroxymethyl-3'-methylallyloxy)-7-methoxy-6-methylphthalide; C000598509:5-(2',3'-epoxy-3',3'-dimethylpropoxy)-7-methoxy-6-methylphthalide; D000970:Antineoplastic Agents; D001572:Benzofurans; C082022:phthalide; C015190:ergostane; D004875:Ergosterol
keywords: Albatrellus confluens; ergostane-type steroid; phthalide derivatives