title: Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells.
abstract: Recently, numerous types of human dental tissue-derived mesenchymal stem cells (MSCs) have been isolated and characterized, including dental pulp stem cells, stem cells from exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle progenitor cells, alveolar bone-derived MSCs, stem cells from apical papilla, tooth germ progenitor cells, and gingival MSCs. All these MSC-like cells exhibit self-renewal, multilineage differentiation potential, and immunomodulatory properties. Several studies have demonstrated the potential advantages of dental stem cell-based approaches for regenerative treatments and immunotherapies. This review outlines the properties of various dental MSC-like populations and the progress toward their use in regenerative therapy. Several dental stem cell banks worldwide are also introduced, with a view toward future clinical application.
authors.affiliation: Department of Ophthalmology, Shanghai Tenth People's Hospital.
authors.forename: Junjun
authors.initials: J
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Yao
authors.initials: Y
authors.lastname: Sun
authors.forename: Beizhan
authors.initials: B
authors.lastname: Jiang
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yang
authors.forename: Guo-Tong
authors.initials: GT
authors.lastname: Xu
authors.forename: Aibin
authors.initials: A
authors.lastname: Liang
authors.forename: Shangfeng
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003782:Dental Pulp / Q000166:cytology*; D003795:Dental Sac / Q000166:cytology*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D023822:Tissue Engineering
keywords: Cell-based therapy; Dental stem cell banks; Dental stem cells; Immunomodulation; Mesenchymal stem cells; Tissue regeneration