title: A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children.
abstract: OBJECTIVE
  The aim of this study is to investigate the efficacy of topical application of mitomycin C after dilation in pediatric patients having post corrosive esophageal stricture.
  
  
  METHODS
  Thirty patients with post corrosive esophageal strictures were divided into two groups: 12 patients had repeated esophageal dilation without mitomycin C application, 18 patients had repeated esophageal dilation and topical application of mitomycin C.
  
  
  RESULTS
  There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0.005). The number of repetition of dilatation ranged from 2 to 6 (median=3) in the 1st group, and 2 to 4 (median=2.5) in the mitomycin C group. There were no adverse effects from the topical application of the mitomycin C.
  
  
  CONCLUSIONS
  Topical application of mitomycin C after oesophageal dilation can be beneficial in improving dysphagia in patients with post corrosive oesophageal stricture.
authors.affiliation: Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: ahmed.sweed@aintree.nhs.uk.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Sweed
authors.affiliation: Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Samya A
authors.initials: SA
authors.lastname: Fawaz
authors.affiliation: Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Waleed F
authors.initials: WF
authors.lastname: Ezzat
authors.affiliation: Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Sabri M
authors.initials: SM
authors.lastname: Sabri
mesh_terms: D000287:Administration, Topical; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000150:complications*; D002424:Caustics; D002648:Child; D002675:Child, Preschool; D003680:Deglutition Disorders / Q000209:etiology / Q000628:therapy; D004106:Dilatation; D004940:Esophageal Stenosis / Q000209:etiology / Q000628:therapy*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D000903:Antibiotics, Antineoplastic; D002424:Caustics; D016685:Mitomycin
keywords: Corrosive esophagitis; Dysphagia; Esophageal dilatation; Esophageal stricture; Topical Mitomycin C