title: Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings.
abstract: Fractional anisotropy (FA) was examined in a priori selected fiber tracts in individuals with schizophrenia (n=25) and their non-psychotic siblings (n=29) versus controls (n=35). FA was reduced in a portion of the fornix in individuals with schizophrenia (although this did not survive correction for the number of tracts investigated). FA in the siblings did not differ from that in controls in any of the investigated tracts.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mharms@wustl.edu.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Harms
authors.affiliation: Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kazi D
authors.initials: KD
authors.lastname: Akhter
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Csernansky
authors.affiliation: Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychology, Washington University, St. Louis, MO, USA.
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Barch
mesh_terms: D000328:Adult; D016880:Anisotropy; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D020712:Fornix, Brain / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D035781:Siblings
keywords: Diffusion tensor imaging (DTI); Endophenotype; Schizophrenia