title: Insulin resistance: cross-talk between adipose tissue and skeletal muscle, through free fatty acids, liver X receptor, and peroxisome proliferator-activated receptor-α signaling.
abstract: Skeletal muscle and adipose tissue play a major role in the regulation of whole-body glucose homeostasis. Much of the coordinated regulation of whole-body glucose homeostasis results from the regulation of lipid storage and release by adipose tissue and efficient switching between glucose oxidation and fatty acid oxidation in skeletal muscle. A control point for these biochemical actions center around the regulation of the insulin responsive glucose transporter, GLUT4. This review examines the regulation of GLUT4 in adipose tissue and skeletal muscle, in the context of the steroid nuclear hormone receptor signaling.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P. O. Box 26901, BMSB 964, Oklahoma City, OK 73190, USA. ann-olson@ouhsc.edu
authors.forename: Ann Louise
authors.initials: AL
authors.lastname: Olson
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D000071518:Liver X Receptors; D018482:Muscle, Skeletal / Q000378:metabolism*; D057093:Orphan Nuclear Receptors / Q000378:metabolism*; D047493:PPAR alpha / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051275:Glucose Transporter Type 4; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047493:PPAR alpha