title: Comparing human exposure to emerging and legacy flame retardants from the indoor environment and diet with concentrations measured in serum.
abstract: This study investigates associations between serum concentrations of emerging and legacy halogenated flame retardants (HFRs) in 46 Norwegian women and measured indoor air and dust concentrations of the HFRs as well as detailed information on diet and household factors. Hexabromobenzene (median 0.03ng/g lipid) and Dechlorane 602 (median 0.18ng/g lipid) were detected in about 50% of the samples and Dechlorane Plus syn (median 0.45ng/g lipid) and anti (median 0.85ng/g lipid) in more than 78%. The most abundant polybrominated diphenyl ethers were 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153; median 0.82ng/g lipid) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47; median 0.49ng/g lipid) detected in more than 70% of the samples. In the bivariate analysis, no consistent associations were observed between the biomonitoring data and measured concentrations in indoor air and dust. On the other hand, consumption of specific food items (mainly lamb/mutton and margarine) correlated significantly with more than two HFR serum concentrations, while this was not the case for household factors (electronic appliances). Only the significant bivariate associations with diet were confirmed by multivariate linear regression analyses, which might indicate a higher contribution from food compared to the indoor environment to the variation of the body burden of these HFRs.
authors.affiliation: Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway; Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain. Electronic address: enrique.cequier@fhi.no.
authors.forename: Enrique
authors.initials: E
authors.lastname: Cequier
authors.affiliation: Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Marcé
authors.affiliation: Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway; Department of Chemistry, University of Oslo, Norway.
authors.forename: Georg
authors.initials: G
authors.lastname: Becher
authors.affiliation: Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Cathrine
authors.initials: C
authors.lastname: Thomsen
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis*; D001822:Body Burden; D002648:Child; D004032:Diet; D004391:Dust / Q000032:analysis; D005260:Female; D005411:Flame Retardants / Q000032:analysis*; D055768:Halogenated Diphenyl Ethers / Q000032:analysis / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000097:blood; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000097:blood; D011083:Polycyclic Compounds / Q000032:analysis / Q000097:blood
chemical_list: D004391:Dust; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D011075:Polybrominated Biphenyls; D011083:Polycyclic Compounds; C556733:dechlorane 602; C517828:hexabrominated diphenyl ether 153; C511295:2,2',4,4'-tetrabromodiphenyl ether
keywords: Blood; Dietary exposure; Dust; Emerging flame retardant; Indoor; Polybrominated diphenyl ether