title: Chronic lymphocytic leukemia with a FGFR3 translocation: case report and literature review of an uncommon cytogenetic event.
abstract: The t(4;14) (p16; q32) with fusion of the IGH (immunoglobulin heavy chain) and FGFR3 (fibroblast growth factor receptor 3) genes are rarely present in patients with chronic lymphocytic leukemia (CLL), with only two previously reported cases. We herein describe a unique case of CLL with the occurrence of a t(4;14) (p16;q32), trisomy 12, and deletion of 11q13-q23 in the same clonal cells. In contrast to myeloma, in which FGFR3 translocations are a common early cytogenetic hit, FGFR3 rearrangement in CLL appears to occur later in the disease course.
authors.affiliation: Division of Hematopathology, Oregon Health & Science University, Portland, OR. Electronic address: geller@ohsu.edu.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Geller
authors.affiliation: Department of Pathology, Boise VA Medical Center, Boise, ID.
authors.forename: Ying
authors.initials: Y
authors.lastname: Pei
authors.affiliation: Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR; Knight Cancer Institute, Oregon Health & Science University, Portland, OR.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Spurgeon
authors.affiliation: Knight Cytogenetics Laboratory, Oregon Health & Science University, Portland, OR.
authors.forename: Connie
authors.initials: C
authors.lastname: Durum
authors.affiliation: Northwest Kaiser Permanente Pathology, Portland, OR.
authors.forename: Nicky J
authors.initials: NJ
authors.lastname: Leeborg
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D020732:Cytogenetic Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D005434:Flow Cytometry; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D016133:Polymerase Chain Reaction; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*; D012196:Review Literature as Topic; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy / Q000235:genetics
chemical_list: D007143:Immunoglobulin Heavy Chains; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3
keywords: Chronic lymphocytic leukemia; FISH; cytogenetic translocation; prognosis