title: Auditory selective attention in adolescents with major depression: An event-related potential study.
abstract: BACKGROUND
  Major depression (MD) is associated with deficits in selective attention. Previous studies in adults with MD using event-related potentials (ERPs) reported abnormalities in the neurophysiological correlates of auditory selective attention. However, it is yet unclear whether these findings can be generalized to MD in adolescence. Thus, the aim of the present ERP study was to explore the neural mechanisms of auditory selective attention in adolescents with MD.
  
  
  METHODS
  24 male and female unmedicated adolescents with MD and 21 control subjects were included in the study. ERPs were collected during an auditory oddball paradigm.
  
  
  RESULTS
  Depressive adolescents tended to show a longer N100 latency to target and non-target tones. Moreover, MD subjects showed a prolonged latency of the P200 component to targets. Across groups, longer P200 latency was associated with a decreased tendency of disinhibited behavior as assessed by a behavioral questionnaire.
  
  
  CONCLUSIONS
  To be able to draw more precise conclusions about differences between the neural bases of selective attention in adolescents vs. adults with MD, future studies should include both age groups and apply the same experimental setting across all subjects.
  
  
  CONCLUSIONS
  The study provides strong support for abnormalities in the neurophysiolgical bases of selective attention in adolecents with MD at early stages of auditory information processing. Absent group differences in later ERP components reflecting voluntary attentional processes stand in contrast to results reported in adults with MD and may suggest that adolescents with MD possess mechanisms to compensate for abnormalities in the early stages of selective attention.
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany. Electronic address: Ellen.Greimel@med.uni-muenchen.de.
authors.forename: E
authors.initials: E
authors.lastname: Greimel
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Trinkl
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Bartling
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Bakos
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany; Translational Brain Medicine in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of the RWTH Aachen/JARA Brain Translational Medicine, Aachen and Juelich, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Grossheinrich
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schulte-Körne
mesh_terms: D000293:Adolescent; D001288:Attention / Q000502:physiology; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology*; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male
keywords: Adolescence; Attention; Auditory oddball; Depression; Event-related potentials