title: Differences between murine and human sepsis.
abstract: Sepsis can be defined as a systemic inflammatory response syndrome occurring in the presence of an infectious source. Over the past 25 years, numerous guidelines have been established to clarify definitions and improve the overall management of clinical sepsis. In light of these multiple paradigm shifts, this review attempts to summarize the innate immunologic alterations that manifest during sepsis, establish and compare mouse models of sepsis with the clinical course, and discuss the authors' views on additional elements that should be considered in modeling and predicting clinical sepsis from the standpoint of a basic research setting.
authors.affiliation: Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Chen
authors.affiliation: Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
authors.forename: Mile
authors.initials: M
authors.lastname: Stanojcic
authors.affiliation: Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Ross Tilley Burn Centre, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address: marc.jeschke@sunnybrook.ca.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Jeschke
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018805:Sepsis / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology
keywords: Anti-inflammatory; Cytokines; Leukocytes; Proinflammatory; Sepsis; Systemic inflammatory response syndrome