title: MOR1 expression in gastric cancer: a biomarker associated with poor outcome.
abstract: BACKGROUND
  At present, the expression of MOR1 and its function in gastric cancer remains unclear with evidence suggesting that it is to be involved in tumor progression and metastasis. The study was to assess the clinicopathologic relevance and prognostic value of MOR1 expression in gastric cancer.
  
  
  METHODS
  Real-time quantitative RT-PCR and immunohistochemical staining were used to detect MOR1 expression in primary gastric cancerous surgical specimens and adjacent nontumorous tissues.
  
  
  RESULTS
  High MOR1 expression was detected in cancerous tumor compared with their adjacent nontumorous tissues. In addition, the chi-square test revealed that high MOR1 expression was significantly correlated with depth of invasion (p = 0.006), lymph node metastasis (p = 0.001), distant metastasis (p = 0.017), and TNM staging (p = 0.027). Moreover, Kaplan-Meier analysis revealed a significant association between MOR1 expression and overall survival. High expression of MOR1 was identified as an independent and significant predictor gene of reduced postoperative survival.
  
  
  CONCLUSIONS
  We conclude that MOR1 expression may be a useful biomarker for better prediction of the clinical outcome and management of gastric cancer patients.
authors.affiliation: Department of Oncology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Ya-sai
authors.initials: YS
authors.lastname: Yao
authors.forename: Ru-yong
authors.initials: RY
authors.lastname: Yao
authors.forename: Li-kun
authors.initials: LK
authors.lastname: Zhuang
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Lv
authors.forename: Fei
authors.initials: F
authors.lastname: Zhou
authors.forename: Wen-sheng
authors.initials: WS
authors.lastname: Qiu
authors.forename: Lu
authors.initials: L
authors.lastname: Yue
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C485764:OPRM1 protein, human; D012333:RNA, Messenger; D017450:Receptors, Opioid, mu
keywords: MOR1; gastric cancer; metastasis; prognosis