title: Polysaccharide-based strategies for heart tissue engineering.
abstract: Polysaccharides are abundant biomolecules in nature presenting important roles in a wide variety of living systems processes. Considering the structural and biological functions of polysaccharides, their properties have raised interest for tissue engineering. Herein, we described the latest advances in cardiac tissue engineering mediated by polysaccharides. We reviewed the data already obtained in vitro and in vivo in this field with several types of polysaccharides. Cardiac injection, intramyocardial in situ polymerization strategies, and scaffold-based approaches involving polysaccharides for heart tissue engineering are thus discussed.
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS, Université Paris 7, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris Cedex 13, France; Inserm, U1148, Cardiovascular Bio-Engineering, X. Bichat Hospital, 46 rue H. Huchard, F-75018 Paris, France.
authors.forename: Amanda K A
authors.initials: AK
authors.lastname: Silva
authors.affiliation: Inserm, U1148, Cardiovascular Bio-Engineering, X. Bichat Hospital, 46 rue H. Huchard, F-75018 Paris, France; Université Paris 13, Sorbonne Paris Cité, F-93430 Villetaneuse, France.
authors.forename: Maya
authors.initials: M
authors.lastname: Juenet
authors.affiliation: Inserm, U1148, Cardiovascular Bio-Engineering, X. Bichat Hospital, 46 rue H. Huchard, F-75018 Paris, France; Université Paris 13, Sorbonne Paris Cité, F-93430 Villetaneuse, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Meddahi-Pellé
authors.affiliation: Inserm, U1148, Cardiovascular Bio-Engineering, X. Bichat Hospital, 46 rue H. Huchard, F-75018 Paris, France; Université Paris 13, Sorbonne Paris Cité, F-93430 Villetaneuse, France. Electronic address: didier.letourneur@inserm.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Letourneur
mesh_terms: D000818:Animals; D006321:Heart; D011134:Polysaccharides / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D011134:Polysaccharides
keywords: Alginate (PubChem CID: 6850754); Cardiac patch; Chitosan (PubChem CID: 71853); Dextran (PubChem CID: 71315856); Fibroblast growth factor (PubChem CID: 5486993); Heart tissue engineering; Hyaluronic acid (PubChem CID: 24759); Polysaccharides; RGD peptide (PubChem CID: 104802); Scaffolds