title: [Role of thiopurine agents in ulcerative colitis].
abstract: Thiopurine agents have been shown to be effective in maintaining remission in patients with Crohn's disease. There is less evidence for the efficacy of these treatments in ulcerative colitis. Consequently, the effect of thiopurines in the latter disease continues to be the subject of debate and controversy remains on whether these drugs are equally effective in both diseases. The present article aims to review, from a practical point of view, the evidence of the efficacy of thiopurines in ulcerative colitis, current indications for this treatment, safety in patients with inflammatory bowel disease and the treatment optimization strategies proposed.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España. mariachs2005@gmail.com
authors.forename: María
authors.initials: M
authors.lastname: Chaparro
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España.
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
mesh_terms: D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007239:Infections / Q000209:etiology; D015122:Mercaptopurine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000209:etiology; D011355:Prodrugs / Q000493:pharmacokinetics; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D011355:Prodrugs; D015122:Mercaptopurine; D001379:Azathioprine
keywords: Azathioprine; Azatioprina; Colitis ulcerosa; Mercaptopurina; Mercaptopurine; Thiopurine; Tiopurina; Ulcerative colitis