title: [Brain-derived neurotrophic factor gene (BDNF) polymorphism among Moscow citizens].
abstract: Recent studies showed that brain-derived neurotrophic factor (BDNF) can participate in pathogenesis of various CNS disorders, being connected with proliferation, differentiation, and survival of neurons. In present study, analysis of occurrence rate was performed for three single nucleotide polymorphisms (SNPs) located in BDNF gene (rs6267 (A/G) allele A-0.265; rs2049046 (A/T) allele A-0.407; rs11030107 (A/G) allele A-0.872) in randomized selection of Moscow citizens. Linkage disequilibrium of rs6165 and rs2049046 loci was shown. Differences in allele frequencies in studied selection and populations of other re- gions were discovered.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kokaeva
authors.forename: T O
authors.initials: TO
authors.lastname: Kochetkova
authors.forename: E V
authors.initials: EV
authors.lastname: Afonchikova
authors.forename: N S
authors.initials: NS
authors.lastname: Kondratyeva
authors.forename: E A
authors.initials: EA
authors.lastname: Klimov
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009031:Moscow; D020641:Polymorphism, Single Nucleotide
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human