title: A systematic review of the effectiveness of intravenous tranexamic acid administration in managing perioperative blood loss in patients undergoing spine surgery.
abstract: This systematic review aimed to identify the effectiveness of intravenous tranexamic acid (TXA) administration in managing perioperative blood loss in patients undergoing spine surgery. The study design was a systematic review and meta-analysis. Quantitative articles were pooled in a statistical meta-analysis using the Joanna Briggs Institute Meta-Analysis of Statistical Assessment and Review Instrument. Twelve studies totaling 934 participants carried out between 1960 and 2013 were included in the review. Intraoperative blood loss showed statistically significant (P < .0001) blood loss in the control group compared with that in the treatment group. Perioperative blood loss was approaching significance for blood loss in the control group with an overall P = .067. TXA helps reduce perioperative blood loss for patients undergoing spine surgery. TXA should be administered to patients undergoing spine surgery when significant blood loss is anticipated.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Badeaux
authors.forename: Diane
authors.initials: D
authors.lastname: Hawley
mesh_terms: D016063:Blood Loss, Surgical; D006801:Humans; D007262:Infusions, Intravenous; D019637:Orthopedic Procedures / Q000009:adverse effects*; D013131:Spine / Q000601:surgery*; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D014148:Tranexamic Acid
keywords: blood loss; intraoperative blood loss; perioperative blood loss; postoperative blood loss; spine surgery or diskectomy or laminectomy or spinal fusion; surgical blood loss; tranexamic acid or tranexamic