title: Muscle wasting and early mobilization in acute respiratory distress syndrome.
abstract: Survivors of acute respiratory distress syndrome often sustain muscle wasting and functional impairment related to intensive care unit (ICU)-acquired weakness (ICUAW) and this disability may persist for years after ICU discharge. Early diagnosis in cooperative patients by physical examination is recommended to identify patients at risk for weaning failure and to minimize prolongation of risk factors for ICUAW. When possible, early rehabilitation in critically ill patients improves functional outcomes, likely by reducing disuse atrophy. Interventions designed to correct the functional impairment are lacking and further research to delineate the molecular pathways that give rise to ICUAW are needed.
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Keenan Centre for Biomedical Science, Li Ka Shing Knowledge institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Walsh
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Keenan Centre for Biomedical Science, Li Ka Shing Knowledge institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
authors.forename: Jane
authors.initials: J
authors.lastname: Batt
authors.affiliation: Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, NCSB 11C-1180, 585 University Avenue, Toronto, ON M5G 2N2, Canada.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Herridge
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Keenan Centre for Biomedical Science, Li Ka Shing Knowledge institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. Electronic address: dossantosc@smh.ca.
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Dos Santos
mesh_terms: D003422:Critical Care; D004434:Early Ambulation; D006801:Humans; D018908:Muscle Weakness / Q000150:complications / Q000534:rehabilitation*; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000534:rehabilitation*
keywords: ARDS; Critical illness; Early rehabilitation; Intensive care unit; Muscle weakness; Neuromuscular disease