title: A review of biotransformation and pharmacology of ginsenoside compound K.
abstract: As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic, anti-inflammation, antiallergic, anti-diabetic, anti-angiogenesis, anti-aging, neuroprotective and hepatoprotective effects. The present review shall summarize recent studies on various biotransformation and pharmacological activities of CK.
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410013, China; School of Pharmaceutical Science, Central South University, Changsha 410013, China.
authors.forename: Xi-Ding
authors.initials: XD
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Science, Central South University, Changsha 410013, China.
authors.forename: Yong-Yu
authors.initials: YY
authors.lastname: Yang
authors.affiliation: Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Ouyang
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410013, China. Electronic address: ygp9880@126.com.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Yang
mesh_terms: D001711:Biotransformation; D036145:Ginsenosides / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D036145:Ginsenosides; C112772:ginsenoside compound K
keywords: Biotransformation; Ginseng; Ginsenoside compound K; Pharmacological activities