title: The two faces of receptor interacting protein kinase-1.
abstract: Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications. Genetic evidence supported by biochemical and cellular biology approaches sheds light on the circumstances in which RIPK1 promotes or inhibits these processes.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Weinlich
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: douglas.green@stjude.org.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Green
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: C506249:RIPK1 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases