title: Structural modifications of coumarin derivatives: Determination  of antioxidant and lipoxygenase (LOX) inhibitory activity.
abstract: In the present project, a series of coumarin analogues, were synthesised and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity. A variety of structural modifications on the coumarin scaffold revealed interesting structure–activity relationships concerning the different biological assays. Prenyloxy-coumarins 9 and 10 displayed the best combined inhibition of lipid peroxidation and soybean lipoxygenase. Thiocoumarins 11 and 14 were identified as potent lipoxygenase inhibitors whereas hydrazone analogues 15 and 16 were efficient DPPH radical scavengers.
authors.affiliation: Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, GR 15773 Athens, Greece. Electronic address: mroussaki@outlook.com.
authors.forename: Marina
authors.initials: M
authors.lastname: Roussaki
authors.affiliation: Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, GR 15773 Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zelianaios
authors.affiliation: Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, GR 15773 Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Kavetsou
authors.affiliation: Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, GR 15773 Athens, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Hamilakis
authors.affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, 54124 Thessaloniki, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Hadjipavlou-Litina
authors.affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, 54124 Thessaloniki, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Kontogiorgis
authors.affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, 54124 Thessaloniki, Greece.
authors.forename: Thalia
authors.initials: T
authors.lastname: Liargkova
authors.affiliation: Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, GR 15773 Athens, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Detsi
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008084:Lipoxygenase / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013025:Glycine max / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D003374:Coumarins; D016859:Lipoxygenase Inhibitors; C030123:coumarin; D008084:Lipoxygenase