title: Effect of media milling on lipid-lowering and antioxidant activities of chitosan.
abstract: The effect of media milling on lipid-lowering and antioxidant activities of chitosan was studied in rats fed high-fat diets. Results showed that media-milled chitosan was more effective than chitosan in reducing body weight gain and liver fat accumulation of rats. Compared with chitosan, the reducing effects of media-milled chitosan on serum triacylglycerol (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were increased by 10.1, 7.5 and 10.2%, and liver TG and TC-reducing effects were increased by 16.2 and 14.6%, respectively. Rats fed media-milled chitosan showed decreased levels of free fatty acid (FFA) and thiobarbituric acid-reactive substances (TBARS) and increased superoxide dismutase (SOD) activity. The cholesterol and fat in feces of rats fed media-milled chitosan were higher than those of rats fed chitosan. These results suggested media milling enhanced the lipid-lowering and antioxidant activities of chitosan, and the reason might be partly due to its effect on strengthening the ability of chitosan in promoting fecal lipid excretions.
authors.affiliation: College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei, PR China. Electronic address: zhangwei_food@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, PR China.
authors.forename: Wenshui
authors.initials: W
authors.lastname: Xia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001709:Biotechnology / Q000379:methods*; D001835:Body Weight / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D005243:Feces / Q000737:chemistry; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008055:Lipids; D014280:Triglycerides; D048271:Chitosan; D002784:Cholesterol
keywords: Antioxidant activity.; Chitosan; Lipid-lowering activity; Media milling