title: Bone healing around nanocrystalline hydroxyapatite, deproteinized bovine bone mineral, biphasic calcium phosphate, and autogenous bone in mandibular bone defects.
abstract: The individual healing profile of a given bone substitute with respect to osteogenic potential and substitution rate must be considered when selecting adjunctive grafting materials for bone regeneration procedures. In this study, standardized mandibular defects in minipigs were filled with nanocrystalline hydroxyapatite (HA-SiO), deproteinized bovine bone mineral (DBBM), biphasic calcium phosphate (BCP) with a 60/40% HA/β-TCP (BCP 60/40) ratio, or particulate autogenous bone (A) for histological and histomorphometric analysis. At 2 weeks, percent filler amongst the test groups (DBBM (35.65%), HA-SiO (34.47%), followed by BCP 60/40 (23.64%)) was significantly higher than the more rapidly substituted autogenous bone (17.1%). Autogenous bone yielded significantly more new bone (21.81%) over all test groups (4.91%-7.74%) and significantly more osteoid (5.53%) than BCP 60/40 (3%) and DBBM (2.25%). At 8 weeks, percent filler amongst the test groups (DBBM (31.6%), HA-SiO (31.23%), followed by BCP 60/40 (23.65%)) demonstrated a similar pattern and was again significantly higher as compared to autogenous bone (9.29%). Autogenous bone again exhibited statistically significantly greater new bone (55.13%) over HA-SiO (40.62%), BCP 60/40 (40.21%), and DBBM (36.35%). These results suggest that the osteogenic potential of HA-SiO and BCP is inferior when compared to autogenous bone. However, in instances where a low substitution rate is desired to maintain the volume stability of augmented sites, particularly in the esthetic zone, HA-SiO and DBBM may be favored.
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.|Private Practice, Studio Borsa Broggini Lanfranchini, Via Stazione 1, Balerna, Switzerland.
authors.forename: Nina
authors.initials: N
authors.lastname: Broggini
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.|Robert K. Schenk Laboratory of Oral Histology, School of Dental Medicine, University of Bern, Bern, Switzerland.
authors.forename: Dieter D
authors.initials: DD
authors.lastname: Bosshardt
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.|Department of Oral & Maxillofacial Surgery, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Jensen
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Bornstein
authors.affiliation: Division of Periodontology, Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Buser
mesh_terms: D000818:Animals; D002417:Cattle; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D017102:Fracture Healing / Q000187:drug effects*; D006882:Hydroxyapatites / Q000737:chemistry / Q000494:pharmacology; D008334:Mandible / Q000378:metabolism / Q000473:pathology; D008338:Mandibular Injuries / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D053758:Nanoparticles / Q000737:chemistry*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D006882:Hydroxyapatites; C074950:hydroxyapatite-beta tricalcium phosphate; D017886:Durapatite
keywords: autogenous bone graft; biphasic calcium phosphate; deproteinized bovine bone mineral; guided bone regeneration; unsintered nanocrystalline hydroxyapatite