title: Imaging-based evaluation of liver function: comparison of ⁹⁹mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI.
abstract: OBJECTIVE
  To compare Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.
  
  
  METHODS
  Fourteen patients underwent Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T max, T 1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.
  
  
  RESULTS
  Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r (2) = 0.802, p = 0.001) and RE for LLL (r (2) = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r (2) = 0.560, p = 0.037) and RE for RLL (r (2) = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r (2) = 0.775, p = 0.002).
  
  
  CONCLUSIONS
  Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.
  
  
  CONCLUSIONS
  • Information about liver function can be acquired with routine Gd-EOB-MRI. • Gd-EOB-MRI and (99m) Tc-mebrofenin HBS show elevated function of non-embolized lobe. • Gd-EOB-MRI and (99m) Tc-mebrofenin HBS can determine lobar liver function.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany, dominik.geisel@charite.de.
authors.forename: Dominik
authors.initials: D
authors.lastname: Geisel
authors.forename: Lutz
authors.initials: L
authors.lastname: Lüdemann
authors.forename: Vera
authors.initials: V
authors.lastname: Fröling
authors.forename: Maciej
authors.initials: M
authors.lastname: Malinowski
authors.forename: Martin
authors.initials: M
authors.lastname: Stockmann
authors.forename: Annekathrin
authors.initials: A
authors.lastname: Baron
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gebauer
authors.forename: Daniel
authors.initials: D
authors.lastname: Seehofer
authors.forename: Vikas
authors.initials: V
authors.lastname: Prasad
authors.forename: Timm
authors.initials: T
authors.lastname: Denecke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000814:Aniline Compounds; D003287:Contrast Media; D004621:Embolization, Therapeutic; D005260:Female; D019786:Gadolinium DTPA; D005998:Glycine; D006801:Humans; D007098:Imino Acids; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies
chemical_list: D000814:Aniline Compounds; D003287:Contrast Media; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C073590:gadolinium ethoxybenzyl DTPA; C034837:technetium Tc 99m mebrofenin; D019786:Gadolinium DTPA; D005998:Glycine