title: Gene-therapy for malaria prevention.
abstract: The limited number of tools for malaria prevention and the inability to eradicate the disease have required large investments in vaccine development, as vaccines have been the only foreseeable type of immunoprophylaxis against malaria. An alternative strategy named vectored immunoprophylaxis (VIP) now would allow genetically transduced host cells to assemble and secrete antibodies that neutralize the infectivity of the malaria parasite and prevent disease.
authors.affiliation: Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, SP, Brazil. Electronic address: mrodrigues@unifesp.br.
authors.forename: Mauricio M
authors.initials: MM
authors.lastname: Rodrigues
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Irene S
authors.initials: IS
authors.lastname: Soares
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D015316:Genetic Therapy; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000276:immunology / Q000592:standards; D019444:Vaccines, DNA / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D016052:Protozoan Vaccines; D019444:Vaccines, DNA
keywords: gene therapy; immune-prophylaxis; malaria prevention