title: Intravenous thrombolysis for acute ischemic stroke.
abstract: Intravenous thrombolysis (IVT) with alteplase remains the standard treatment for acute ischemic stroke. Although IVT can be started up to 4.5 hours after symptoms' onset, it is all the more effective and safe when started early. It allows a 10% absolute reduction in the risk of handicap or death at 3 months, despite a 2-7% risk of symptomatic intracranial hemorrhage. Current research efforts involve firstly trying to treat a larger proportion of patients by overcoming some of the contraindications to IVT and secondly assessing combined or alternative treatments to achieve a higher early recanalization rate.
authors.affiliation: Stroke unit, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; Inserm UMR S894, France. Electronic address: g.turc@ch-sainte-anne.fr.
authors.forename: G
authors.initials: G
authors.lastname: Turc
authors.affiliation: Stroke unit, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France.
authors.forename: C
authors.initials: C
authors.lastname: Isabel
authors.affiliation: Stroke unit, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; Inserm UMR S894, France.
authors.forename: D
authors.initials: D
authors.lastname: Calvet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000209:etiology*; D061345:Early Medical Intervention; D006801:Humans; D007262:Infusions, Intravenous; D020300:Intracranial Hemorrhages / Q000139:chemically induced; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator
keywords: Interventional radiology; Ischemia; Stroke; Thrombectomy; Thrombolysis