title: Efficacy of psychoeducational family intervention for bipolar I disorder: A controlled, multicentric, real-world study.
abstract: BACKGROUND
  This study assessed the efficacy of the Falloon model of psychoeducational family intervention (PFI), originally developed for schizophrenia management and adapted to bipolar I disorder. The efficacy of the intervention was evaluated in terms of improvement of patients׳ social functioning and reduction of family burden.
  
  
  METHODS
  This was a multicentre, real-world, controlled, outpatient trial carried out in 11 randomly recruited Italian mental health centres. Enroled patients and key-relatives were consecutively allocated either to receive PFI and Treatment As Usual (TAU) or to a waiting list receiving TAU alone. The efficacy of the intervention was evaluated in terms of improvement in patients׳ social functioning (primary outcome) and reduction of family burden (secondary outcome).
  
  
  RESULTS
  Of the 137 recruited families, 70 were allocated to the experimental group and 67 to the control group. At the end of the intervention, significant improvements in patients׳ social functioning and in relatives׳ burden were found in the treated group compared to TAU. This effect of the intervention remained also after controlling for several confounding patient׳s socio-demographic and clinical factors. The experimental intervention had an impact also on other outcome measures, such as patients׳ clinical status and personal burden.
  
  
  CONCLUSIONS
  Lack of an active control group.
  
  
  CONCLUSIONS
  The results of this study clearly show that the psychoeducational family intervention according to the Falloon model is effective in improving the social outcome of patients with bipolar I disorder.
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy. Electronic address: anfioril@tin.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fiorillo
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Del Vecchio
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Luciano
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Sampogna
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: De Rosa
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Malangone
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Volpe
authors.affiliation: Mental Health Centre of Grosseto, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bardicchia
authors.affiliation: Mental Health Centre of Lanciano, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ciampini
authors.affiliation: Pavia University, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Crocamo
authors.affiliation: Mental Health Centre of Montecatini, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Iapichino
authors.affiliation: Mental Health Centre of Lanusei, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Lampis
authors.affiliation: Niguarda Hospital, Milan, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Moroni
authors.affiliation: Mental Health Centre of Sassuolo, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Orlandi
authors.affiliation: Mental Health Centre of Foligno, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Piselli
authors.affiliation: Mental Health Centre of Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Pompili
authors.affiliation: Mental Health Department of Campobasso, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Veltro
authors.affiliation: University College of London, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carrà
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna Delle Grazie, 80138 Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006266:Health Education / Q000379:methods*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012107:Research Design; D012559:Schizophrenia / Q000628:therapy
keywords: Bipolar I disorder; Family; Family burden; Outcome; Psychoeducation; Social functioning