title: Introduction to the special issue on heart regeneration and rejuvenation.
abstract: Despite therapeutic advances that slow its progression, heart disease remains the world's leading cause of death. Until recently, the "Holy Grail" of cardiac biology, to regenerate the damaged heart, appeared to be a fantastical and quixotic quest. However, recent studies showing that the mammalian heart possesses an innate, albeit limited, regenerative capacity offer hope that effective cardiac regeneration may be an attainable goal. This Special Issue of Stem Cell Research reviews the remarkable progress that has been made in this field in the last few years.
authors.affiliation: Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst 2010, New South Wales, Australia. Electronic address: r.harvey@victorchang.edu.au.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Harvey
authors.affiliation: Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst 2010, New South Wales, Australia. Electronic address: b.graham@victorchang.edu.au.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Graham
authors.affiliation: Department of Cardiology, Boston Children's Hospital, Enders 1254, 300 Longwood Ave, Boston, MA 02115, USA. Electronic address: wpu@pulab.org.
authors.forename: William T
authors.initials: WT
authors.lastname: Pu
mesh_terms: D000818:Animals; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D012038:Regeneration; D012060:Rejuvenation