title: "Post-it" type connected DNA created with a reversible covalent cross-link.
abstract: We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.
authors.affiliation: Department of Chemistry and Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München (Germany) http://www.carellgroup.de.
authors.forename: María
authors.initials: M
authors.lastname: Tomás-Gamasa
authors.forename: Sascha
authors.initials: S
authors.lastname: Serdjukow
authors.forename: Meng
authors.initials: M
authors.lastname: Su
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Carell
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry; D044366:Transition Temperature
chemical_list: D000447:Aldehydes; D000588:Amines; D003432:Cross-Linking Reagents; D009711:Nucleotides; D004247:DNA
keywords: DNA; DNA cross-linking; DNA nanostructures; imines; reversible bonding