title: Parkinson's disease as a member of Prion-like disorders.
abstract: Parkinson's disease is one of several neurodegenerative diseases associated with a misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha-synuclein and its neuronal deposits in the form of Lewy bodies are considered a hallmark of the disease. In this review we describe the clinical and experimental data that have led to think of alpha-synuclein as a prion-like protein and we summarize data from in vitro, cellular and animal models supporting this view.
authors.affiliation: The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: meh67@cam.ac.uk.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Herva
authors.affiliation: The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Spillantini
mesh_terms: D000818:Animals; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism*; D011328:Prions / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017510:Protein Folding; D051844:alpha-Synuclein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D011328:Prions; D051844:alpha-Synuclein
keywords: Alpha-synuclein; Misfolding; Parkinson; Prion; Spreading