title: HIV: a vicTIM.
abstract: TIM proteins are known to promote viral entry into host cells. Unexpectedly, a recent study has shown that TIM proteins also inhibit HIV-1 release from the host cell by directly binding to phosphatidylserine exposed on the virus surface, providing details on a new role of TIM proteins in HIV replication.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
authors.forename: Jiri
authors.initials: J
authors.lastname: Vlach
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294. Electronic address: saad@uab.edu.
authors.forename: Jamil S
authors.initials: JS
authors.lastname: Saad
mesh_terms: D015497:HIV-1 / Q000502:physiology*; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D054884:Host-Pathogen Interactions; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D011991:Receptors, Virus / Q000378:metabolism*; D057074:Virus Release
chemical_list: C491143:HAVCR1 protein, human; C448908:HAVCR2 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011991:Receptors, Virus; C512411:TIMD4 protein, human
keywords: HIV; TIM; phosphatidylserine (PS)