title: Advanced lung cancer: aggressive surgical therapy vertebral body involvement.
abstract: The NOMS considerations provide a dynamic decision framework to determine the optimal combination of systemic and radiation therapies and surgery. Generally, NSCLC metastases to the spine require SRS because cEBRT usually fails to provide consistent long-term local control. Patients with spinal cord compression secondary to NSCLC require surgical decompression to safely undergo SRS and to reduce the risk of radiation-induced spinal cord injury. Separation surgery allows spinal cord decompression and spinal stabilization using the posterior approach and, in combination with SRS, has been shown to provide reliable local control with low risk of wound complication or spinal hardware fracture.
authors.affiliation: Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Bilsky
authors.affiliation: Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Laufer
authors.affiliation: Plastic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Matros
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Yamada
authors.affiliation: Thoracic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: ruschv@mskcc.org.
authors.forename: Valerie W
authors.initials: VW
authors.lastname: Rusch
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary / Q000601:surgery*; D019299:Decompression, Surgical / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D009362:Neoplasm Metastasis; D013125:Spinal Neoplasms / Q000556:secondary / Q000601:surgery*; D013131:Spine
keywords: Lung cancer; NOMS; Spine involvement