title: Two new furaldehyde compounds from the rhizomes of Gastrodia elata.
abstract: Two new compounds 5-[4'-(4″-hydroxybenzyl)-3'-hydroxybenzyloxymethyl]-furan-2-carbaldehyde (1) and 5-[4'-(4″-hydroxybenzyl)-3'-hydroxybenzyl]-furan-2-carbal-dehyde (2), together with two known 5-(4-hydroxbenzyloxymethyl)-furan-2-carbaldehyde] (3) and 5-(hydroxymethyl)-2-furaldehyde (4), were isolated from the rhizome of Gastrodia elata. Their structures were elucidated by spectroscopic analysis and comparison of their spectral data with those reported previously. All compounds exhibited weak or no cytotoxicity against human colon carcinoma cell line (HT-29) and human chronic myelogenous leukemia cell line (K-562).
authors.affiliation: a College of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , P.R. China.
authors.forename: Lu-Qiang
authors.initials: LQ
authors.lastname: Huang
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Cui
authors.forename: Yang-Hui
authors.initials: YH
authors.lastname: Ou
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Xiong
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Huang
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031668:Gastrodia / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
chemical_list: C000598794:5-(4'-(4''-hydroxybenzyl)-3'-hydroxybenzyl)-furan-2-carbaldehyde; C000598793:5-(4'-(4''-hydroxybenzyl)-3'-hydroxybenzyloxymethyl)furan-2-carbaldehyde; D004365:Drugs, Chinese Herbal; D010636:Phenols; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde
keywords: Gastrodia elata; HT-29; K-562; cytotoxicity assay; furaldehyde