title: A case of Alzheimer's disease following mild traumatic brain injury.
abstract: OBJECTIVE
  To report a case of Alzheimer's disease (AD) following mild traumatic brain injury (TBI).
  
  
  METHODS
  Case report.
  
  
  RESULTS
  We report the time course of AD following mild TBI with evidence of AD pathology. A patient complained of minor memory disturbance 6 months after TBI and was diagnosed with mild cognitive impairment 1.5 years after TBI, and she was finally diagnosed as probable AD 4 years after TBI. Amyloid PET revealed brain accumulation of beta-amyloid at a pathological AD level.
  
  
  CONCLUSIONS
  Our case well illustrated how TBI can accelerate the AD process. Clinicians should carefully follow up patients with persistent cognitive impairment after TBI.
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
authors.forename: Amane
authors.initials: A
authors.lastname: Tateno
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakayori
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takizawa
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Minagawa
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan. Electronic address: okubo-y@nms.ac.jp.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications*; D060825:Cognitive Dysfunction / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged
keywords: Alzheimer's disease; Beta-amyloid; Mild cognitive impairment; Positron emission tomography; Traumatic brain injury