title: [Signs of diabetic cardiomyopathy in patients with controlled arterial hypertension and early postprandial hyperglycemia].
abstract: OBJECTIVE
  To study signs of diabetic cardiomyopathy (DCM) in nondiabetic patients with controlled arterial hypertension (AH) and glycemic response during first hour of glucose tolerance test (GTT).
  
  
  METHODS
  Patients (n = 47) with controlled AH were divided into 2 groups according to results of GTT with 75 g of glucose: patients of group 1 (n = 22) had glucose level ≤ 200 mg/dl during 1-st hour of GTT; other patients (n = 25) composed group 2. Examination of all patients included transthoracic echocardiography, ultrasound Dopplerography, tissue Doppler (TD) and 24-hour Holter ECG monitoring. Using data of these methods we calculated left ventricular (LV) mass and the following characteristics of mitral ring: E/A, TD e', TD a', TD s', TD e'/a'/. The following characteristics of heart rate variability were obtained: standard deviation of normal RR intervals (SDNN), low and high frequency (LF, HF) power, LF/HF ratio.
  
  
  RESULTS
  Patients of group 2 had higher LV mass (229.5 ± 58.2 vs. 192.1 ± 50.6 g; p = 0.036), more pronounced changes of TD e'/a' (0.71 ± 0.25 vs. 1.06 ± 0.58; p = 0.011), lower SDNN both during day (85.4 ± 14.1 vs. 112.5 ± 31.3 ms, p = 0.007) and night (82.2 ± 22.1 vs. 105.9 ± 28.5 ms, p = 0,004) time, higher nocturnal LF/HF ratio (3.75 ± 4.02 vs. 1.72 ± 0.81, p = 0,029).
  
  
  CONCLUSIONS
  In patients with controlled arterial hypertension (AH) and glycemic response during first hour of GCT we revealed various pronounced manifestations of DCM. These data constitute a basis for further studies.
authors.forename: K É
authors.initials: KÉ
authors.lastname: Kagliian
authors.forename: D V
authors.initials: DV
authors.lastname: Fettser
authors.forename: S
authors.initials: S
authors.lastname: Kirim
authors.forename: S
authors.initials: S
authors.lastname: Turkmen
authors.forename: M
authors.initials: M
authors.lastname: Balli
authors.forename: K
authors.initials: K
authors.lastname: Tekin
authors.forename: R
authors.initials: R
authors.lastname: Akilli
authors.forename: O
authors.initials: O
authors.lastname: Karaaslan
authors.forename: T
authors.initials: T
authors.lastname: Seker
authors.forename: M
authors.initials: M
authors.lastname: Kaĭli
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Arystanova
authors.forename: T A
authors.initials: TA
authors.lastname: Batyraliev
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination; D003627:Data Interpretation, Statistical; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018615:Ultrasonography, Doppler, Color; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents