title: Screening, prevention, and treatment of congenital cytomegalovirus.
abstract: Congenital cytomegalovirus (CMV) is a leading cause of permanent disability in children. The main source of maternal infection is from contact with young children. Primary maternal infection is diagnosed with demonstration of seroconversion or a positive CMV IgM in combination with a low-avidity CMV IgG. Fetal infection may be diagnosed with amniotic fluid polymerase chain reaction and culture. CMV-specific hyperimmune globulin has shown promise as a possible means to prevent congenital infection; large randomized trials are ongoing. To date, the only effective means of prevention is through reducing exposure to the virus. Rates of maternal infection may be reduced through education regarding sources of infection and improved hygiene.
authors.affiliation: Department of Obstetrics & Gynecology, Women & Infants Hospital, Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA. Electronic address: jujohnson@wihri.org.
authors.forename: Julie
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Department of Obstetrics & Gynecology, Women & Infants Hospital, Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA.
authors.forename: Brenna
authors.initials: B
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006920:Hygiene / Q000592:standards*; D007116:Immunization, Passive / Q000379:methods*; D007136:Immunoglobulins / Q000302:isolation & purification*; D016756:Immunoglobulins, Intravenous; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D008403:Mass Screening; D010353:Patient Education as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D011296:Prenatal Diagnosis / Q000379:methods; D040242:Risk Reduction Behavior
chemical_list: D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; C045781:cytomegalovirus-specific hyperimmune globulin
keywords: CMV diagnosis; CMV hyperimmune globulin; CMV prevention; Congenital infection; Cytomegalovirus