title: Prevalence of asymptomatic coronary disease in fibrosing idiopathic interstitial pneumonias.
abstract: BACKGROUND
  Because of growing body of interest on the association between fibrosing idiopathic interstitial pneumonias (f-IIP) and ischaemic heart disease, we initiated this prospective study to evaluate the prevalence of asymptomatic coronary artery disease (CAD) in patients with f-IIP.
  
  
  METHODS
  Forty-two patients with f-IIP underwent noninvasive screening for CAD that included (a) a chest CT examination enabling calculation of the coronary artery calcium (CAC) score, then depiction of coronary artery stenosis; and (b) stress myocardial perfusion scintigraphy (MPS). Patients with significant coronary abnormalities, defined by a CAC score >400 or coronary artery stenosis >50% at CT and/or perfusion defect >5% at MPS, were referred to the cardiologist. Coronary angiography was indicated in presence of a perfusion defect >10% at MPS or significant left main or proximal left anterior descending stenosis whatever MPS findings.
  
  
  RESULTS
  Combining CT and MPS, significant abnormalities were detected in 32/42 patients (76%). The cardiologist: (a) did not consider further investigation in 21 patients (CT abnormalities but no ischaemia at MPS: 12/21; false-positive findings at MPS: 3/21; poor respiratory condition: 6/21); (b) proceeded to coronary angiography in 11 patients which confirmed significant stenoses in 5 patients (5/42; 12%). In the worst-case-scenario (i.e., inclusion of 6 patients with significant coronary artery abnormalities who were not investigated due to poor respiratory condition), the prevalence of CAD reached 26% (11/42).
  
  
  CONCLUSIONS
  In the studied population of patients with f-IIP, asymptomatic CAD ranged between 12% and 26%.
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Cassagnes
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Vianney
authors.initials: V
authors.lastname: Gaillard
authors.affiliation: Department of Pulmonology, Center of Competence for Rare Pulmonary Diseases, Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Monge
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Faivre
authors.affiliation: Department of Cardiology, Cardiology Hospital, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Delhaye
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Francesco
authors.initials: F
authors.lastname: Molinari
authors.affiliation: Department of Nuclear Medicine, Hospital Salengro, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Petyt
authors.affiliation: Department of Nuclear Medicine, Hospital Salengro, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Hossein-Foucher
authors.affiliation: Department of Pulmonology, Center of Competence for Rare Pulmonary Diseases, Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Wallaert
authors.affiliation: Department of Medical Statistics (EA 2694), Univ Lille Nord de France, F-59000 Lille, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Remy
authors.affiliation: Department of Thoracic Imaging (EA 2694), Hospital Calmette, CHRU and Univ Lille 2 Nord de France, F-59000 Lille, France. Electronic address: martine.remy@chru-lille.fr.
authors.forename: Martine
authors.initials: M
authors.lastname: Remy-Jardin
mesh_terms: D000368:Aged; D015897:Comorbidity; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Atherosclerosis; Chest CT; Coronary arteries; Interstitial lung disease; Lung diseases