title: A patient with cholangiocarcinoma demonstrating pathologic complete response to chemotherapy: exploring the role of neoadjuvant therapy in biliary tract cancer.
abstract: The role of neoadjuvant chemotherapy and/or radiation for localized or potentially resectable cholangiocarcinoma (CCA) has not been well established. We present here the case of a patient with an extrahepatic CCA who achieved a pathologic complete response after undergoing preoperative gemcitabine-based chemotherapy, without sequential or concurrent use of radiation. Further evaluation of neoadjuvant strategies in CCA, including not only combined-modality therapy but also the use of chemotherapy exclusively, is warranted in prospective study design.
authors.affiliation: 1 Division of Hematology/Oncology, 2 Departments of Anatomic Pathology, Urology and Radiation Oncology, 3 Department of Surgery, University of California, San Francisco, USA.
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Walker
authors.affiliation: 1 Division of Hematology/Oncology, 2 Departments of Anatomic Pathology, Urology and Radiation Oncology, 3 Department of Surgery, University of California, San Francisco, USA.
authors.forename: Jeffry P
authors.initials: JP
authors.lastname: Simko
authors.affiliation: 1 Division of Hematology/Oncology, 2 Departments of Anatomic Pathology, Urology and Radiation Oncology, 3 Department of Surgery, University of California, San Francisco, USA.
authors.forename: Eric K
authors.initials: EK
authors.lastname: Nakakura
authors.affiliation: 1 Division of Hematology/Oncology, 2 Departments of Anatomic Pathology, Urology and Radiation Oncology, 3 Department of Surgery, University of California, San Francisco, USA.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Ko
keywords: Cholangiocarcinoma (CCA); chemotherapy; complete response; neoadjuvant