title: Anisomycin administered in the olfactory bulb and dorsal hippocampus impaired social recognition memory consolidation in different time-points.
abstract: To identify an individual as familiar, rodents form a specific type of memory named social recognition memory. The olfactory bulb (OB) is an important structure for social recognition memory, while the hippocampus recruitment is still controversial. The present study was designed to elucidate the OB and the dorsal hippocampus contribution to the consolidation of social memory. For that purpose, we tested the effect of anisomycin (ANI), which one of the effects is the inhibition of protein synthesis, on the consolidation of social recognition memory. Swiss adult mice with cannulae implanted into the CA1 region of the dorsal hippocampus or into the OB were exposed to a juvenile during 5 min (training session; TR), and once again 1.5 h or 24 h later to test social short-term memory (S-STM) or social long-term memory (S-LTM), respectively. To study S-LTM consolidation, mice received intra-OB or intra-CA1 infusion of saline or ANI immediately, 3, 6 or 18 h after TR. ANI impaired S-LTM consolidation in the OB, when administered immediately or 6h after TR. In the dorsal hippocampus, ANI was amnesic only if administered 3 h after TR. Furthermore, the infusion of ANI in either OB or CA1, immediately after training, did not affect S-STM. Moreover, ANI administered into the OB did not alter the animal's performance in the buried food-finding task. Altogether, our results suggest the consolidation of S-LTM requires both OB and hippocampus participation, although in different time points. This study may help shedding light on the specific roles of the OB and dorsal hippocampus in social recognition memory.
authors.affiliation: Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627-CEP, Campus Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: R R
authors.initials: RR
authors.lastname: Pena
authors.affiliation: Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627-CEP, Campus Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Pereira-Caixeta
authors.affiliation: Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627-CEP, Campus Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: M F D
authors.initials: MF
authors.lastname: Moraes
authors.affiliation: Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627-CEP, Campus Pampulha, 31270-901 Belo Horizonte, MG, Brazil. Electronic address: grace@icb.ufmg.br.
authors.forename: G S
authors.initials: GS
authors.lastname: Pereira
mesh_terms: D000367:Age Factors; D000818:Animals; D000841:Anisomycin / Q000633:toxicity*; D003213:Conditioning, Psychological / Q000187:drug effects; D004195:Disease Models, Animal; D005239:Fear / Q000523:psychology; D005247:Feeding Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D051379:Mice; D019384:Nucleic Acid Synthesis Inhibitors / Q000633:toxicity*; D009830:Olfactory Bulb / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects*; D012919:Social Behavior; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D000841:Anisomycin
keywords: Anisomycin; Dorsal hippocampus; Olfactory bulb; Social recognition memory