title: The protective effect of apelin on ischemia/reperfusion injury.
abstract: Apelin is the endogenous ligand for the APJ, a member of the G protein coupled receptors family. Apelin/APJ system is widely distributed in central nervous system and peripheral tissues, especially in heart, lung and kidney. Apelin plays important physiological and pathological roles in cardiovascular system, immune system, neuroprotection, etc. This article outlines the protective effect of apelin on ischemia/reperfusion (I/R) injury. Apelin could activate multiple protective mechanisms to prevent heart, brain, liver and kidney I/R injury. Apelin/APJ system may be a promising therapeutic target for ischemic and other related diseases.
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China. Electronic address: shuangyulv@henu.edu.cn.
authors.forename: Shuang-Yu
authors.initials: SY
authors.lastname: Lv
authors.affiliation: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Shuang-Kun
authors.initials: SK
authors.lastname: Lyu
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wu
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000073861:Apelin; D001921:Brain / Q000098:blood supply; D015687:Cell Hypoxia; D002560:Cerebrovascular Circulation; D003331:Coronary Vessels / Q000503:physiopathology; D006321:Heart / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D007511:Ischemia / Q000378:metabolism*; D065840:Protective Factors; D015427:Reperfusion Injury / Q000378:metabolism*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins
keywords: APJ; Apelin; Brain; Heart; Ischemia/reperfusion injury