title: [Mesalazine old and new].
abstract: Aminosalycylates (5-ASA) are still the drugs of choice both for mild-to-moderate outbreaks of ulcerative colitis and to maintain long-term remission. The efficacy of these drugs has been widely demonstrated in placebo-controlled trials. However, when administered orally, their pharmacological characteristics hamper the desired therapeutic effect. Currently, efficiency can be optimized by exclusive or combined rectal administration. The present article reviews the available data on the efficacy of galenic preparations of 5-ASA and discusses the potential advantages of galenic forms of 5-ASA coated with a novel multi-matrix delivery system.
authors.affiliation: Unidad de Enfermedades Inflamatorias Intestinales, Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Míriam
authors.initials: M
authors.lastname: Mañosa
authors.affiliation: Unidad de Enfermedades Inflamatorias Intestinales, Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España, Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España. Electronic address: edomenech.germanstrias@gencat.cat.
authors.forename: Eugeni
authors.initials: E
authors.lastname: Domènech
mesh_terms: D000284:Administration, Oral; D000285:Administration, Rectal; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004339:Drug Compounding; D006801:Humans; D019804:Mesalamine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013608:Tablets, Enteric-Coated
chemical_list: D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013608:Tablets, Enteric-Coated; D019804:Mesalamine
keywords: Aminosalicilatos; Aminosalycylates; Colitis ulcerosa; Mesalazina; Mesalazine; Multi-matrix; Multimatrix; Ulcerative colitis