title: Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study.
abstract: Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 was also assessed (immunohistochemistry) on sural nerve biopsies from POEMS and vasculitic neuropathy patients. No correlation was found between PTX3 and VEGF levels in POEMS or controls. Sural nerve biopsies from vasculitic neuropathy patients, but not those from POEMS syndrome, showed strong PTX3 staining. PTX3, expression of vessel inflammation/remodeling, and VEGF, crucial pro-angiogenic cytokine, appear to be independently regulated in POEMS syndrome.
authors.affiliation: Department of Neurosciences, Sciences NPSRR, University of Padova, Italy. Electronic address: chiara.briani@unipd.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.affiliation: Department of Neurosciences, Sciences NPSRR, University of Padova, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dalla Torre
authors.affiliation: Department of Medicine, Haematology Unit, University of Padova, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Lessi
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cavallaro
authors.affiliation: Neuroscience, Department of Neurology & INSPE, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Scarlato
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Ferrari
authors.affiliation: Department of Neurosciences, Sciences NPSRR, University of Padova, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Campagnolo
authors.affiliation: Department of Neurosciences, Sciences NPSRR, University of Padova, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Lucchetta
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cabrini
authors.affiliation: 3rd Neurology Unit, IRCCS Fondazione Istituto Neurologico "Carlo Besta", Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Morbin
authors.affiliation: 3rd Neurology Unit, IRCCS Fondazione Istituto Neurologico "Carlo Besta", Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.affiliation: Department of Medicine, Haematology Unit, University of Padova, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Adami
authors.affiliation: Internal Medicine, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Manfredi
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000378:metabolism* / Q000473:pathology*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013497:Sural Nerve / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D042461:Vascular Endothelial Growth Factor A; D000099153:Pentraxins
keywords: POEMS syndrome; Pentraxin 3; Polyneuropathy; Vascular endothelial growth factor (VEGF); Vasculitis