title: Alginate electrodeposition onto three-dimensional porous Co-Ni films as drug delivery platforms.
abstract: Three-dimensional porous Co-Ni films/alginate hybrid materials have been successfully prepared by electrodeposition to be used as a steerable magnetic device for drug delivery. Firstly, 3D porous Co-Ni films were prepared as substrates for the subsequent electrodeposition of the alginate biopolymer. Cyclic voltammetry, galvanostatic and potentiostatic studies were performed to establish the best conditions to obtain porous Co-Ni films. The electrochemical experiments were carried out in an electrolyte containing the metal salts and ammonium chloride at low pHs. In a second stage, the electrochemical deposition of alginate as a biocompatible polymer drug delivery carrier was performed. The characteristics of the alginate matrix were investigated in terms of electrochemical properties, morphology and drug release. The hybrid material obtained showed soft-magnetic behavior and drug release indicating its suitability to be used as a steerable magnetic drug delivery device.
authors.affiliation: Ge-CPN, Physical Chemistry Department, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès, 1. 08028 Barcelona, Spain. garcia.torres.jm@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: García-Torres
authors.forename: C
authors.initials: C
authors.lastname: Gispert
authors.forename: E
authors.initials: E
authors.lastname: Gómez
authors.forename: E
authors.initials: E
authors.lastname: Vallés
mesh_terms: D000464:Alginates / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D016503:Drug Delivery Systems; D004595:Electroplating; D020723:Glucuronic Acid / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D000464:Alginates; D006454:Hemoglobins; D006603:Hexuronic Acids; D003035:Cobalt; D009532:Nickel; D020723:Glucuronic Acid