title: The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis.
abstract: OBJECTIVE
  To confirm the association between troponin elevation in patients with sepsis and mortality.
  
  
  BACKGROUND
  Cardiac troponins are sensitive and specific biomarkers of myocardial injury; however their prognostic significance in patients with sepsis is still debated.
  
  
  METHODS
  PubMed and Ovid MEDLINE were searched for original articles using MeSH terms 'Troponin' and 'Sepsis.' Studies reporting on mortality in patients with sepsis, severe sepsis or septic shock who had troponin measured were eligible for inclusion. Meta-analysis was conducted with Review Manager.
  
  
  RESULTS
  Seventeen studies, with total sample size of 1857 patients were included. Elevated troponin was found to be significantly associated with mortality (Risk ratio: 1.91; 95% CI: 1.65-2.22; p < 0.05).
  
  
  CONCLUSIONS
  Troponin elevation in patients with sepsis confers poorer prognosis and is a predictor of mortality. Further studies are needed to see if more aggressive treatment of this subset of patients, or utilizing new therapeutic approaches will improve mortality.
authors.affiliation: Department of Medicine, Harlem Hospital Center, in affiliation with the College of Physicians and Surgeons of Columbia University, New York, USA. Electronic address: oas2120@columbia.edu.
authors.forename: Olusegun
authors.initials: O
authors.lastname: Sheyin
authors.affiliation: Department of Medicine, Harlem Hospital Center, in affiliation with the College of Physicians and Surgeons of Columbia University, New York, USA.
authors.forename: Oluwaseun
authors.initials: O
authors.lastname: Davies
authors.affiliation: Department of Medicine, Harlem Hospital Center, in affiliation with the College of Physicians and Surgeons of Columbia University, New York, USA.
authors.forename: Wenlan
authors.initials: W
authors.lastname: Duan
authors.affiliation: Department of Medicine, Harlem Hospital Center, in affiliation with the College of Physicians and Surgeons of Columbia University, New York, USA.
authors.forename: Xavier
authors.initials: X
authors.lastname: Perez
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D011379:Prognosis; D012306:Risk; D018805:Sepsis / Q000401:mortality / Q000503:physiopathology*; D012772:Shock, Septic / Q000401:mortality / Q000503:physiopathology*; D014336:Troponin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D014336:Troponin
keywords: Meta-analysis; Mortality; Prognosis; Sepsis; Shock; Troponin