title: How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors.
abstract: SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France.
authors.forename: Carmen
authors.initials: C
authors.lastname: Ruggiero
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France.
authors.forename: Mabrouka
authors.initials: M
authors.lastname: Doghman
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France. Electronic address: ninino@ipmc.cnrs.fr.
authors.forename: Enzo
authors.initials: E
authors.lastname: Lalli
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D008957:Models, Genetic; D009928:Organ Specificity / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear
keywords: Adrenal cortex; Endocrine cancers; Nuclear receptors; Transcription factors