title: C16:0-ceramide signals insulin resistance.
abstract: A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance (Turpin et al., 2014; Raichur et al., 2014).
authors.affiliation: Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Hla
authors.affiliation: Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: r-kolesnick@ski.mskcc.org.
authors.forename: Richard
authors.initials: R
authors.lastname: Kolesnick
mesh_terms: D000818:Animals; D002518:Ceramides / Q000378:metabolism*; D059305:Diet, High-Fat; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D051049:Sphingosine N-Acyltransferase / Q000378:metabolism*
chemical_list: D002518:Ceramides; D051049:Sphingosine N-Acyltransferase