title: Hearing loss in a pediatric patient following cisplatin chemotherapy and subsequent exposure to excessive noise.
abstract: Cisplatin is a commonly-used chemotherapeutic agent that is highly-effective against a variety of pediatric cancers. Unfortunately, it may lead to ototoxicity, with serious consequences on the quality of life of survivors. Patients remain at risk of progression of ototoxicity even after completion of treatment. We report the case of a medulloblastoma survivor with previously documented normal hearing, who developed significant hearing loss and tinnitus following exposure to excessive noise at a nightclub three years after completion of treatment. We highlight the importance of long-term audiological follow up and education about the increased risk of hearing loss in this population.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
authors.forename: Emilia
authors.initials: E
authors.lastname: Peleva
authors.affiliation: Faculté de Médicine de Montpellier, Université Montpellier 1, Montpellier, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Aloy
authors.affiliation: Division of Hematology-Oncology, Department of Pediatrics, CHU Sainte-Justine/Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Carret
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada. Electronic address: sam.daniel@mcgill.ca.
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Daniel
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects*; D006317:Hearing Loss, Noise-Induced / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy; D014012:Tinnitus / Q000209:etiology*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Cisplatin; Late effects; Noise-induced hearing loss; Ototoxicity; Pediatric oncology; Progressive hearing loss