title: Interferon gamma in autoimmunity: A complicated player on a complex stage.
abstract: Early views of autoimmune disease cast IFNγ as a prototypic pro-inflammatory factor. It is now clear that IFNγ is capable of both pro- and anti-inflammatory activities with the functional outcome dependent on the physiological and pathological setting examined. Here, the major immune modulatory activities of IFNγ are reviewed and current evidence for the impact of IFNγ on pathology and regulation of several autoimmune diseases and disease models is summarized.
authors.affiliation: Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: jason.lees@usuhs.edu.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Lees
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors; D007249:Inflammation / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D007371:Interferon-gamma
keywords: Autoimmunity; Immune pathology; Immune regulation; Inflammation; Interferon gamma