title: Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with Ginkgo biloba.
abstract: In a clinical pilot study with eleven metabolic syndrome patients, a simultaneous decrease in hs-CRP from 8.85 ± 4.09 to 4.92 ± 2.51 mg/L (-44.4%) (p < 0.0436) and HOMA-IR from 3.07 ± 0.63 to 2.60 ± 0.51 mU/L × mg/dL (-15.3%) (p < 0.0120) as well as a beneficial change of arteriosclerotic, inflammatory and oxidative stress biomarkers were detected after 2-month treatment with Ginkgo biloba. Furthermore, both IL-6 (-12.9%, p < 0.0407) and nanoplaque formation (-14.3%, p < 0.0077) were additionally reduced. According to a large clinical trial elucidating the importance of insulin resistance and low-grade systemic inflammation for cardiovascular disease and overall mortality risk, these data might indicate a CVD/total mortality risk reduction.
authors.affiliation: Charité - University Clinic Berlin, 10117 Berlin, Germany; University of Uppsala Biomedical Center, 751 23 Uppsala, Sweden. Electronic address: guenter.siegel@charite.de.
authors.forename: G
authors.initials: G
authors.lastname: Siegel
authors.affiliation: Charité - University Clinic Berlin, 10117 Berlin, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Ermilov
authors.affiliation: Swiss Analysis AG, 8274 Tägerwilen, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Knes
authors.affiliation: Charité - University Clinic Berlin, 10117 Berlin, Germany; Scienion AG, 12489 Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism / Q000517:prevention & control; D004032:Diet; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000178:diet therapy / Q000188:drug therapy*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D018384:Oxidative Stress; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D000096983:Ginkgo Extract
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract
keywords: CVD/total mortality risk; Ginkgo biloba; High-sensitivity C-reactive protein (hs-CRP); Homeostasis model assessment of insulin resistance (HOMA-IR); Metabolic syndrome patients