title: Information processing speed impairment and cerebellar dysfunction in relapsing-remitting multiple sclerosis.
abstract: OBJECTIVE
  The aim of this work is to study the relationship between information processing speed (IPS) impairment and motor testing that reflects cerebellar function in persons with multiple sclerosis (PwMS).
  
  
  METHODS
  60 persons with relapsing-remitting multiple sclerosis with a mean disease duration of 4.2 ± 4 years were studied cross-sectionally. Motor cerebellar functioning was studied using the Nine-Hole Peg Test (NHPT) and the Kurtzke Functional Status Scales, and several cognitive domains were evaluated (IPS, working memory, episodic memory, attention, executive function). Correlations between the global NHPT score and neuropsychological test scores or impairment in each cognitive domain were studied using univariate and multivariate analyses.
  
  
  RESULTS
  The NHPT and a test of IPS significantly differentiated PwMS with and without cerebellar impairment. The NHPT total score was correlated with measures of IPS. Multivariate analyses showed a correlation between the NHPT and measures of IPS, but not between the NHPT and other neuropsychological tests that did not have a speed component.
  
  
  CONCLUSIONS
  In this sample of PwMS, motor cerebellar impairment assessed by the NHPT was correlated with IPS impairment.
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ruet
authors.affiliation: Neurocentre Magendie, INSERM U862, Université de Bordeaux, F-33076 Bordeaux, France; Translational Research and Advanced Imaging Laboratory (TRAIL) cluster of excellence, Université de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Hamel
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Mathilde S A
authors.initials: MS
authors.lastname: Deloire
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Charré-Morin
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Saubusse
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France; Neurocentre Magendie, INSERM U862, Université de Bordeaux, F-33076 Bordeaux, France; Translational Research and Advanced Imaging Laboratory (TRAIL) cluster of excellence, Université de Bordeaux, F-33076 Bordeaux, France. Electronic address: bruno.brochet@chu-bordeaux.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Brochet
mesh_terms: D000328:Adult; D001288:Attention; D002526:Cerebellar Diseases / Q000503:physiopathology*; D003071:Cognition; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008606:Mental Processes; D008875:Middle Aged; D009043:Motor Activity; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D012720:Severity of Illness Index
keywords: Cerebellum; Cognition; Information processing speed; Multiple sclerosis; Neuropsychology