title: A prospective study on pulse wave velocity (PWV) and response to anti-hypertensive treatments: PWV determines BP control.
abstract: OBJECTIVE
  Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important relationships with BP progression; however, little information is available on the role of PWV in blood pressure (BP) control. We aimed to assess BP control during the run-in treatment period in the China Stroke Primary Prevention Trial (CSPPT).
  
  
  RESULTS
  These analyses included a total of 3056 treated hypertensive subjects (age: 59.6±7.5years, male/female 1339/1717) with PWV measured at baseline. The average BP at enrollment was 166/95mmHg, and declined to 141/85mmHg after short-term antihypertensive treatment (a median follow-up of 20days). There was an inverse relationship between PWV level and BP reduction during the treatment, most notably for systolic BP (with estimated coefficients of -9.01 (P<0.001) for the top quartile, as compared to the bottom quartile). The association did not differ significantly by gender or types of antihypertensive drugs. Factors related to smaller BP decline were low baseline BP, high baseline PWV, high body mass index, high creatinine, use of fewer types of antihypertensive drug, high heart rate (only for SBP), high homocysteine and low age (only for DBP).
  
  
  CONCLUSIONS
  PWV appears to be an independent determinant of individual response to anti-hypertensive treatment.
authors.affiliation: Heart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Cardiology Department, Peking University First Hospital, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Center for Clinical Research in Kidney Disease, Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: National Center for Clinical Research in Kidney Disease, Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China.
authors.forename: Xianhui
authors.initials: X
authors.lastname: Qin
authors.affiliation: Institute of Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Genfu
authors.initials: G
authors.lastname: Tang
authors.affiliation: Institute of Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Houxun
authors.initials: H
authors.lastname: Xing
authors.affiliation: Cardiology Department, Peking University First Hospital, Beijing, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Fan
authors.affiliation: Cardiology Department, Peking University First Hospital, Beijing, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.affiliation: Cardiology Department, Peking University First Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Center for Clinical Research in Kidney Disease, Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China.
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.affiliation: National Center for Clinical Research in Kidney Disease, Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
authors.affiliation: Heart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address: yangxc99@gmail.com.
authors.forename: Xinchun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents
keywords: Arterial stiffness; Blood pressure; Hypertension; Pulse wave velocity