title: The metabolic syndrome and risk of coronary artery disease in patients with chronic schizophrenia or schizoaffective disorder in a chronic mental institute.
abstract: The prevalence rate of metabolic syndrome (MS) and coronary artery disease (CAD) has been found to be high in patients with chronic schizophrenia. Current evidence shows that CAD is underdiagnosed in this group. Our study evaluated the prevalence of MS and the risk of CAD in patients with chronic schizophrenia in a chronic care mental hospital in southern Taiwan. We included all patients with the diagnosis of schizophrenia or schizoaffective disorder. We collected all laboratory, physical examination, psychiatric interview, and chart review data. We also evaluated the risk of CAD in these patients using the Framingham point system. There was no significant age difference in the MS prevalence rate in these patients. The young patients with schizophrenia in our study tended to have a higher prevalence of MS than the general population. In addition, female patients had a higher prevalence rate of MS than males. Based on the Framingham point system, we found the 10-year risk of CAD to be higher among the patients with schizophrenia than in the general population. Our study highlights the importance of the high risk of MS in both younger and older patients with schizophrenia, without a significant relationship to the use of antipsychotics. More complete cohort studies are needed to confirm these findings. Psychiatrists may want to establish more specific and detailed clinical guidelines for patients with chronic schizophrenia with comorbid physical diseases, especially MS and CAD.
authors.affiliation: Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan.
authors.forename: Ping-Tao
authors.initials: PT
authors.lastname: Tseng
authors.affiliation: Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan.
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan.
authors.forename: Yu-Shian
authors.initials: YS
authors.lastname: Cheng
authors.affiliation: Division of Endocrinology and Metabolism, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Feng-Chih
authors.initials: FC
authors.lastname: Shen
authors.affiliation: Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
authors.forename: Pao-Yen
authors.initials: PY
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan. Electronic address: wckuan@ms28.hinet.net.
authors.forename: Ching-Kuan
authors.initials: CK
authors.lastname: Wu
mesh_terms: D000367:Age Factors; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology*; D003710:Demography; D005260:Female; D006778:Hospitals, Psychiatric / Q000706:statistics & numerical data*; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology*; D008875:Middle Aged; D015995:Prevalence; D011618:Psychotic Disorders / Q000150:complications*; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications*; D013624:Taiwan / Q000453:epidemiology
keywords: Cardiovascular disease; Coronary artery disease; Framingham point system; Metabolic syndrome; Schizophrenia