title: Intestinal obstruction in pregnancy by ondansetron.
abstract: BACKGROUND
  Ondansetron use for nausea and vomiting during pregnancy has increased in the last years, although its maternal and fetal safety is not conclusive.
  
  
  METHODS
  We describe a case of intestinal obstruction in a pregnant woman with severe nausea and vomiting of pregnancy treated with ondansetron, which is known to slow gut motility.
  
  
  CONCLUSIONS
  The spontaneous reporting system of WHO confirms that this potentially life threatening complication is more common than what the peer review literature may suggest and needs to be looked into carefully, especially in view of the wide spread off-label use for NVP.
authors.affiliation: Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Rana
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: meitalym42@gmail.com.
authors.forename: Meital
authors.initials: M
authors.lastname: Shlomo
authors.affiliation: Pharmaceutical Division, Ministry of Health, Israel.
authors.forename: Dorit Nahlieli
authors.initials: DN
authors.lastname: Dil
authors.affiliation: Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Natalia
authors.initials: N
authors.lastname: Dinavitser
authors.affiliation: Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Mati
authors.initials: M
authors.lastname: Berkovitch
authors.affiliation: Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; The Motherisk Program, Division of Clinical Pharmacology-Toxicology, Department of Pediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Canada. Electronic address: gkoren@sickkids.ca.
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced*; D017294:Ondansetron / Q000009:adverse effects*; D011247:Pregnancy; D012702:Serotonin Antagonists / Q000009:adverse effects*
chemical_list: D000932:Antiemetics; D012702:Serotonin Antagonists; D017294:Ondansetron
keywords: 5-HT3 receptor antagonist; Adverse event; Hyperemesis gravidarum; Intestinal obstruction; Ondansetron; Pregnancy