title: Interval debulking surgery following neo-adjuvant chemotherapy for stage IVB ovarian cancer using neutral argon plasma (PlasmaJet™).
abstract: OBJECTIVE
  We present a novel surgical approach to ovarian cancer debulking using neutral argon plasma (PlasmaJet™).
  
  
  METHODS
  A 48 year-old woman diagnosed with FIGO stage IVB grade 3 serous epithelial ovarian carcinoma received three cycles of neoadjuvant chemotherapy with carboplatin and paclitaxel.
  
  
  METHODS
  Dissection and radical debulking surgery were performed using PlasmaJet™ as previously described [1,2]. This included diaphragmatic and abdominal peritoneal stripping, supra-colic omentectomy, tumour ablation on the small and large intestines and mesentery, pelvic and para-aortic lymphadenectomy.
  
  
  RESULTS
  The only post-operative complication was a superficial wound breakdown, which healed by secondary intention. She remains well two years after surgery, with no sign of recurrence.
  
  
  CONCLUSIONS
  In this case, PlasmaJet™ facilitated diaphragmatic peritoneal stripping as well as dissection of tissue close to bowel and major vessels. Further study is required to assess whether this device can reduce the need for bowel resection while achieving complete cytoreduction.
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, GuildfordGU2 7XX, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Butler-Manuel
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, GuildfordGU2 7XX, UK. Electronic address: jalippiatt@doctors.org.uk.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lippiatt
authors.affiliation: Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, GuildfordGU2 7XX, UK.
authors.forename: Thumuluru Kavitha
authors.initials: TK
authors.lastname: Madhuri
mesh_terms: D001128:Argon / Q000627:therapeutic use*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D001128:Argon
keywords: Cytoreduction; Debulking; Lymphadenectomy; Ovarian; Plasma; Surgery