title: Leptin mediates seasonal variation in some but not all symptoms of sickness in Siberian hamsters.
abstract: Many seasonally breeding species, including Siberian hamsters (Phodopus sungorus), exhibit seasonal variation in sickness responses. One hypothesis regarding the mechanism of this variation is that sickness intensity tracks an animal's energetic state, such that sickness is attenuated in the season that an animal has the lowest fat stores. Energetic state may be signaled via leptin, an adipose hormone that provides a signal of fat stores. Siberian hamsters respond to extended housing in short, winter-like days by reducing fat stores and leptin levels, relative to those housed in long, summer-like days. Sickness responses are also attenuated in short-day hamsters as compared to long-day hamsters. We hypothesized that leptin provides a physiological signal by which seasonally breeding animals modulate sickness responses, such that animals with higher leptin levels show increased sickness intensity. To test this, we provided short-day hamsters with a long-day-like leptin signal and assessed their responses to lipopolysaccharide (LPS), a sickness-inducing antigen. We compared these responses to short-day vehicle-, long-day vehicle-, and long-day leptin-treated hamsters. Unexpectedly, LPS induced a hypothermic response (rather than fever) in all groups. Short-day vehicle-treated hamsters exhibited the greatest LPS-induced hypothermia, and leptin treatment attenuated this response, making hypothermia more long-day-like. Contrary to our hypothesis, short-day leptin-treated hamsters showed the least pronounced LPS-induced anorexia among all groups. These results suggest that leptin may mediate some but not all aspects of seasonal sickness variation in this species. Future studies should be targeted at determining roles of other energetic hormones in regulating seasonal sickness response variation.
authors.affiliation: Department of Biology, Program in Neuroscience and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, USA. Electronic address: elcarlto@indiana.edu.
authors.forename: Elizabeth D
authors.initials: ED
authors.lastname: Carlton
authors.affiliation: Department of Biology, Program in Neuroscience and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, USA.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Demas
mesh_terms: D059445:Anhedonia / Q000187:drug effects; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D006224:Cricetinae; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary; D055809:Illness Behavior / Q000187:drug effects*; D015918:Infusion Pumps, Implantable; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D009425:Nesting Behavior / Q000187:drug effects; D017111:Phodopus / Q000502:physiology; D017440:Photoperiod; D012621:Seasons
chemical_list: D020738:Leptin; D008070:Lipopolysaccharides
keywords: Ecoimmunology; Energetics; Infection-induced anorexia; Infection-induced hypothermia; Lipopolysaccharide; Seasonality