title: Severe acute vision loss, dyschromatopsia, and changes in the ellipsoid zone on sd-oct associated with intravitreal ocriplasmin injection.
abstract: OBJECTIVE
  To present the long-term follow-up of a patient injected with intravitreal ocriplasmin who experienced severe acute post-intravitreal ocriplasmin complications.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 68-year-old man with vitreomacular traction was treated with intravitreal ocriplasmin. He experienced dyschromatopsia, severe acute visual acuity, and field loss 4 hours after the injection. This was accompanied by decreased reflectivity on spectral domain optical coherence tomography in the ellipsoid zone of the outer retina. These changes were transient, and 3 years after the injection, the patient is asymptomatic and no outer reflectivity changes are noted on his spectral domain optical coherence tomography images.
  
  
  CONCLUSIONS
  Acute visual changes and spectral domain optical coherence tomography hyporeflectivity in the ellipsoid zone after intravitreal ocriplasmin can occur in some individuals, but in this case, these changes were reversible, and there have been no long-term implications.
authors.affiliation: California Retina Consultants and Research Foundation, Santa Barbara, California.
authors.forename: Carlos
authors.initials: C
authors.lastname: Quezada Ruiz
authors.forename: Dante J
authors.initials: DJ
authors.lastname: Pieramici
authors.forename: Maʼan
authors.initials: M
authors.lastname: Nasir
authors.forename: Melvin
authors.initials: M
authors.lastname: Rabena
authors.forename: Robert L
authors.initials: RL
authors.lastname: Avery
mesh_terms: D000208:Acute Disease; D000368:Aged; D001766:Blindness / Q000139:chemically induced* / Q000175:diagnosis; D005341:Fibrinolysin / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000009:adverse effects*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin