title: Penthorin A and B, two unusual 2,4'-epoxy-8,5'-neolignans from Penthorum chinese.
abstract: Two new 2,4'-epoxy-8,5'-neolignans (1 and 2), together with five known 7,9';7',9-diepoxylignans (3-7), were isolated from an ethyl acetate soluble portion of a hepatoprotective water decoction of Penthorum chinese. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. This is the second report of 2,4'-epoxy-8,5'-neolignans from plants. Compounds 2, 6, and 7 showed in vitro protective activities against acetaminophen-induced hepatocyte injury at 5 μM.
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
authors.forename: Ya-Cong
authors.initials: YC
authors.lastname: He
authors.affiliation: Department of Chemistry, University of Pennsylvania, 231 S. 34 Street, Philadelphia, PA 19104-6323, United States.
authors.forename: Yike
authors.initials: Y
authors.lastname: Zou
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address: pengchengchengdu@126.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Liu
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: He
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Xie
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address: xiling0505@126.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Xiong
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D002460:Cell Line; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D017705:Lignans; C000597716:penthorin A; C000597717:penthorin B; D000082:Acetaminophen
keywords: 2,4′-Epoxy-8,5′-neolignans; Absolute configuration; ECD calculation; Hepatoprotective activity; Penthorum chinese