title: Experimental infection of tree shrews (Tupaia belangeri) with Coxsackie virus A16.
abstract: Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews (Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Li
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Li-Chun
authors.initials: LC
authors.lastname: Wang
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Feng
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China. imbcams.lq@gmail.com.
authors.forename: Qi-Han
authors.initials: QH
authors.lastname: Li
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China.longdingl@gmail.com.
authors.forename: Long-Ding
authors.initials: LD
authors.lastname: Liu
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D003384:Coxsackievirus Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D004770:Enterovirus / Q000502:physiology*; D005260:Female; D014018:Tissue Distribution; D014418:Tupaiidae; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral
keywords: Coxsackie virus A16; Infection; Tree shrew