title: Production of intraperitoneal interleukin-6 following open or laparoscopic assisted distal gastrectomy.
abstract: The interleukin (IL)-6 concentration in plasma or serum has been considered to represent the degree of stress resulting from surgery. However, IL-6 in peritoneal fluid has rarely been considered. The aim of this study was to assess the concentration and amount of IL-6 in peritoneal fluid as indicators of surgical stress. To obtain basic data on peritoneal release of IL-6 during gastric cancer surgery, we measured IL-6 in peritoneal drainage samples, stored for up to 72 hours postoperatively, from patients who had undergone conventional open (ODG group, n = 20) and laparoscopic-assisted (LADG group, n = 19) distal gastrectomy. Within 24 hours, 61 and 77% of the IL-6 was released into the peritoneal cavity in the LADG and ODG groups, respectively. In both groups, the concentration and amount of peritoneal fluid IL-6 were significantly correlated with each other (LADG group: Spearman's rank correlation test [rS] = 0.48, P = 0.04; ODG group: rS = 0.58, P = 0.01). The concentration and amount of IL-6 in peritoneal fluid was 2.8- and 3.6-fold higher in the ODG than in the LADG group, respectively (P < 0.01). With regard to the relationship between the serum C-reactive protein (CRP) peak and the concentration or amount of peritoneal fluid IL-6 released within 24 hours, only the concentration of peritoneal fluid IL-6 in the LADG group was significantly correlated (rS = 0.60, P = 0.01) with the serum CRP peak. Our findings suggest that the amount and concentration of IL-6 released into the peritoneal cavity for up to 24 hours after surgery can each be a reliable parameter for assessment of surgical stress.
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tajima
authors.forename: Toru
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Norihiro
authors.initials: N
authors.lastname: Haga
authors.forename: Hideko
authors.initials: H
authors.lastname: Imaizumi
authors.forename: Okihide
authors.initials: O
authors.lastname: Suzuki
authors.forename: Koki
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Takeaki
authors.initials: T
authors.lastname: Matsuzawa
authors.forename: Jun
authors.initials: J
authors.lastname: Sobajima
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D004322:Drainage; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D005773:Gastroscopy; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: Cytokine; Gastrectomy; Gastric cancer; Interleukin (IL)-6; Laparoscopic surgery; Peritoneal fluid; Surgical stress