title: Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results.
abstract: We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥6 months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, NY, USA. Electronic address: Andrew.Rosenkrantz@nyumc.org.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Rosenkrantz
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Rice
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Natasha E
authors.initials: NE
authors.lastname: Wehrli
authors.affiliation: Department of Pathology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Deng
authors.affiliation: Department of Urology, Division of Urologic Oncology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Samir S
authors.initials: SS
authors.lastname: Taneja
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology*; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen
keywords: Biopsy; MRI; PSA; Prostate cancer