title: A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity.
abstract: OBJECTIVE
  Several studies have reported the effects of prebiotics and synbiotics supplementation in lipid profile and glucose homeostasis, however a pooled analysis of clinical trials that assessed these parameters has not been performed in overweight or obese individuals. The aim of this study was to evaluate the effects of prebiotics and synbiotics on plasma lipid profile, fasting insulin and fasting glucose in adults with overweight or obesity.
  
  
  METHODS
  Randomized controlled trials were systematically searched before May 2014 in electronic databases and screening reference lists. Combined and stratified (diabetics and non-diabetics trials) meta-analyzes were performed.
  
  
  RESULTS
  Thirteen trials, representing 513 adult participants with Body Mass Index ≥25 kg/m² were included. Prebiotic supplementation reduced plasma total cholesterol (SMD -0.25; 95% CI -0.48, -0.02) and LDL-c (SMD -0.22; 95% CI -0.44, -0.00) concentrations in overall analysis, and reduced triglycerides (SMD -0.72; 95% CI -1.20, -0.23) and increased HDL-c (SMD 0.49; 95% CI 0.01, 0.97) concentrations in diabetic trials. Synbiotic supplementation reduced plasma fasting insulin (SMD -0.39; 95% CI -0.75, -0.02) and triglycerides (SMD -0.43; 95% CI -0.70, -0.15) concentrations.
  
  
  CONCLUSIONS
  The improvement of the evaluated parameters supports prebiotics and synbiotics supplementation as an adjuvant therapy in obesity-related comorbidities, such as dyslipidemia and insulin resistance.
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Bruna T S
authors.initials: BT
authors.lastname: Beserra
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fernandes
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Vinicius A
authors.initials: VA
authors.lastname: do Rosario
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Michel C
authors.initials: MC
authors.lastname: Mocellin
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Marilyn G F
authors.initials: MG
authors.lastname: Kuntz
authors.affiliation: Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil. Electronic address: erasmotrindade@gmail.com.
authors.forename: Erasmo B S M
authors.initials: EB
authors.lastname: Trindade
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D016208:Databases, Factual; D005215:Fasting; D006801:Humans; D007328:Insulin / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000628:therapy; D050177:Overweight / Q000097:blood* / Q000628:therapy; D056692:Prebiotics / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D058616:Synbiotics / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D056692:Prebiotics; D014280:Triglycerides; D002784:Cholesterol
keywords: Meta-analysis; Obesity; Overweight; Prebiotic; Synbiotic