title: Age-related hair changes in men: mechanisms and management of alopecia and graying.
abstract: The appearance of human scalp hair is often tied to perceptions of youth and virility, especially in men. Hair loss, or alopecia and hair graying are commonly associated with advancing age and are frequently a source for emotional distress and anxiety. Our understanding of the complex molecular signals and mechanisms that regulate and influence the hair follicle has expanded in recent years. By harnessing this understanding we are poised to address the esthetic concerns of aging hair. Additionally, changes in the hair follicle may be a reflection of systemic senescent signals, thus because of its accessibility, the hair follicle may serve as an important research tool in gerontology. In this review, the most current knowledge and research regarding mechanisms of androgenetic alopecia, senescent alopecia, and graying are discussed, as are extrinsic factors that may contribute to hair changes with age. Evidence based management strategies for treatment of age-related hair changes are also reviewed.
authors.affiliation: Department of Dermatology, The Permanente Medical Group, Vallejo, CA, United States; Department of Dermatology, University of California, San Francisco, San Francisco, CA, United States; Department of Dermatology, Case Western Reserve University, Cleveland, OH, United States. Electronic address: paradi.mirmirani@kp.org.
authors.forename: Paradi
authors.initials: P
authors.lastname: Mirmirani
mesh_terms: D000375:Aging; D000505:Alopecia / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D008297:Male
keywords: Alopecia; Androgenetic alopecia; Graying; Hair loss; Male pattern balding; Senescent alopecia