title: Acute liver failure following atorvastatin dose escalation: is there a threshold dose for idiosyncratic hepatotoxicity?
authors.affiliation: Department of Internal Medicine, Hospital of Laredo, Laredo, Cantabria, Spain. Electronic address: miguel.carrascosa@scsalud.es.
authors.forename: Miguel F
authors.initials: MF
authors.lastname: Carrascosa
authors.affiliation: Department of Internal Medicine, Gastroenterology Section, Hospital of Laredo, Laredo, Cantabria, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Salcines-Caviedes
authors.affiliation: Unidad de Gestión Clínica de Aparato Digestivo y Hepatología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA and Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Lucena
authors.affiliation: Unidad de Gestión Clínica de Aparato Digestivo y Hepatología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA and Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors.forename: Raul J
authors.initials: RJ
authors.lastname: Andrade
mesh_terms: D000369:Aged, 80 and over; D000069059:Atorvastatin / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000069059:Atorvastatin