title: Anti-hyperglycemic and anti-hyperlipidemic potential of a polyherbal preparation "Diabegon" in metabolic syndrome subject with type 2 diabetes.
abstract: BACKGROUND
  In the present study, "Diabegon" a poly-herbal preparation, with hypoglycemic activity, was evaluated for its preventive effect in metabolic syndrome subjects with type 2 diabetes and also to reveal its side effects, on liver and kidney.
  
  
  METHODS
  Type 2 diabetic subjects with metabolic syndrome (N=58) were categorized on the basis of age and fasting blood glucose. The grouping was as follows: Group I (35-50 yrs), Group II (51-65 yrs), Group III >65 yrs, Group IV FBS<145.9, Group V FBS>145. Each group was administered 4 gm of diabegon daily. Blood glucose levels, lipid profile, liver and kidney function of the subjects were regularly monitored within 3 months of interval to 18 months.
  
  
  RESULTS
  The reduction in fasting blood glucose level ranged from 12.3% (P<0.05) to 42% (P<0.001) after 18 month of therapy whereas in postprandial blood glucose, the decrease ranged from 28% (P<0.05) to 32% (P<0.05) after 18 month of therapy. Overall reductions in the individual parameters of the metabolic syndrome subjects were significantly higher in Group I. Cholesterol level decreased from 11% to 27.2% (P<0.001), triglyceride levels decreased from 24% to 55%, VLDL and LDL levels reduced by 60% & 54% respectively after 18 months of therapy. The HDL-C level increased in all groups. Moreover, diabegon administration for 1.5 years exhibited no alteration in liver and kidney function tests, which indicate its non-toxicity.
  
  
  CONCLUSIONS
  Our study suggests that diabegon could be included as a preventive treatment in metabolic syndrome subjects with type 2 diabetes especially for long term treatment as it efficiently shows anti-hyperglycemic and anti-lipidemic effects with no adverse impacts on the liver and kidney.
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea ; SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Yadav
authors.affiliation: SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: Arvind
authors.initials: A
authors.lastname: Tiwari
authors.affiliation: School of Life Sciences, Sambalpur University, Jyoti Vihar, Burla(Odisha).
authors.forename: Meerambika
authors.initials: M
authors.lastname: Mishra
authors.affiliation: SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: Senthil S
authors.initials: SS
authors.lastname: Subramanian
authors.affiliation: School of Environmental Science, JNU-New Delhi.
authors.forename: Usha Singh
authors.initials: US
authors.lastname: Baghel
authors.affiliation: SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: P S
authors.initials: PS
authors.lastname: Bisen
authors.affiliation: SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.
authors.forename: G B K S
authors.initials: GB
authors.lastname: Prasad
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: Diabegon; Metabolic syndrome; Polyherbal preparation; Type 2 diabetes