title: Adolescent social defeat disturbs adult aggression-related impulsivity in wild-type rats.
abstract: Adolescence is generally considered as a developmental period during which adverse social experiences may have lasting consequences in terms of an increased vulnerability to affective disorders. This study aimed at determining the individual susceptibility to adolescent social stress using a rat model. We used rats of the Wild-type Groningen strain, which are characterized by a broad variation in adult levels of aggression and impulsivity. We hypothesized that experience of social defeat in adolescence results in heightened aggression and impulsivity levels in adulthood. In contrast to our expectation, adolescent social defeat did not lead to a difference in the average adult level of aggression and impulsivity, but the significant correlation between offensive aggression and impulsivity found in control animals was not present in animals defeated during adolescence.
authors.affiliation: Department of Behavioural Physiology, University of Groningen, PO Box 11103, 9700 CC Groningen, The Netherlands. Electronic address: C.M.Coppens@rug.nl.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Coppens
authors.affiliation: Department of Behavioural Physiology, University of Groningen, PO Box 11103, 9700 CC Groningen, The Netherlands.
authors.forename: Alex
authors.initials: A
authors.lastname: Coolen
authors.affiliation: Department of Behavioural Physiology, University of Groningen, PO Box 11103, 9700 CC Groningen, The Netherlands.
authors.forename: Sietse F
authors.initials: SF
authors.lastname: de Boer
authors.affiliation: Department of Behavioural Physiology, University of Groningen, PO Box 11103, 9700 CC Groningen, The Netherlands.
authors.forename: Jaap M
authors.initials: JM
authors.lastname: Koolhaas
mesh_terms: D000367:Age Factors; D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004291:Dominance-Subordination; D007175:Impulsive Behavior / Q000502:physiology*; D008297:Male; D051381:Rats
keywords: Adolescence; Aggression; Coping style; Impulsivity; Social defeat