title: Cost-effectiveness of PET and PET/computed tomography: a systematic review.
abstract: The development of clinical diagnostic procedures comprises early-phase and late-phase studies to elucidate diagnostic accuracy and patient outcome. Economic assessments of new diagnostic procedures compared with established work-ups indicate additional cost for 1 additional unit of effectiveness measure by means of incremental cost-effectiveness ratios when considering the replacement of the standard regimen by a new diagnostic procedure. This article discusses economic assessments of PET and PET/computed tomography reported until mid-July 2014. Forty-seven studies on cancer and noncancer indications were identified but, because of the widely varying scope of the analyses, a substantial amount of work remains to be done.
authors.affiliation: Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, Odense 5000, Denmark; Department of Business and Economics, Centre of Health Economics Research, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark. Electronic address: oke.gerke@rsyd.dk.
authors.forename: Oke
authors.initials: O
authors.lastname: Gerke
authors.affiliation: Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3 sal, Odense 5000, Denmark.
authors.forename: Ronnie
authors.initials: R
authors.lastname: Hermansson
authors.affiliation: Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, Odense 5000, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Hess
authors.affiliation: Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, Odense 5000, Denmark; Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3 sal, Odense 5000, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Schifter
authors.affiliation: Clinical Epidemiology, Department of Medical Biometry and Medical Informatics, University of Freiburg, Stefan-Meier-Straße 26, Freiburg 79104, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Vach
authors.affiliation: Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, Odense 5000, Denmark; Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3 sal, Odense 5000, Denmark.
authors.forename: Poul Flemming
authors.initials: PF
authors.lastname: Høilund-Carlsen
mesh_terms: D003362:Cost-Benefit Analysis / Q000191:economics; D019788:Fluorodeoxyglucose F18 / Q000191:economics*; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006801:Humans; D038622:Internationality; D064847:Multimodal Imaging / Q000191:economics*; D009369:Neoplasms / Q000191:economics* / Q000453:epidemiology*; D049268:Positron-Emission Tomography / Q000191:economics*; D019275:Radiopharmaceuticals / Q000191:economics; D014057:Tomography, X-Ray Computed / Q000191:economics*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Computed tomography; Cost-benefit analysis; Cost-effectiveness; Economics; PET