title: Free estradiol and sex hormone-binding globulin.
abstract: SHBG is a plasma protein that participates in the regulation of free estradiol and free testosterone in plasma. We discuss the concept of the nature of a free estradiol and how best to ascertain its value. It can be measured or calculated; the ways in which this can be done are explored along with the advantages and disadvantages of each.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: wr7@columbia.edu.
authors.forename: William
authors.initials: W
authors.lastname: Rosner
mesh_terms: D004958:Estradiol / Q000032:analysis* / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D017698:Postmenopause; D012738:Sex Hormone-Binding Globulin / Q000032:analysis* / Q000378:metabolism*; D014462:Ultrafiltration / Q000379:methods*
chemical_list: D012738:Sex Hormone-Binding Globulin; D004958:Estradiol
keywords: Assay; Estradiol; Free estradiol; Free testosterone; SHBG