title: Endoscopic management of acute peptic ulcer bleeding.
abstract: This review discusses the indications, technical aspects, and comparative effectiveness of the endoscopic treatment of upper gastrointestinal bleeding caused by peptic ulcer. Pre-endoscopic considerations, such as the use of prokinetics and timing of endoscopy, are reviewed. In addition, this article examines aspects of postendoscopic care such as the effectiveness, dosing, and duration of postendoscopic proton-pump inhibitors, Helicobacter pylori testing, and benefits of treatment in terms of preventing rebleeding; and the use of nonsteroidal anti-inflammatory drugs, antiplatelet agents, and oral anticoagulants, including direct thrombin and Xa inhibitors, following acute peptic ulcer bleeding.
authors.affiliation: Division of Gastroenterology, McGill University Health Center, McGill University, 1650 Cedar Avenue, Montréal H3G 1A4, Canada.
authors.forename: Yidan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Division of Gastroenterology, McGill University Health Center, McGill University, 1650 Cedar Avenue, Montréal H3G 1A4, Canada.
authors.forename: Yen-I
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology, McGill University Health Center, McGill University, 1650 Cedar Avenue, Montréal H3G 1A4, Canada; Division of Clinical Epidemiology, McGill University Health Center, McGill University, 687 Pine Avenue West, Montréal H3A 1A1, Canada. Electronic address: alan.barkun@muhc.mcgill.ca.
authors.forename: Alan
authors.initials: A
authors.lastname: Barkun
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D000075202:Contraindications; D004381:Duodenal Ulcer / Q000150:complications*; D004564:Electrocoagulation / Q000379:methods; D016099:Endoscopy, Gastrointestinal; D016558:Hemostasis, Endoscopic / Q000295:instrumentation / Q000379:methods*; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors; D011208:Powders / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D018570:Risk Assessment; D013276:Stomach Ulcer / Q000150:complications*; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D011208:Powders; D054328:Proton Pump Inhibitors
keywords: Duodenal ulcer; Endoscopy; Gastric ulcer; Nonvariceal upper gastrointestinal hemorrhage; Peptic ulcer bleeding; Upper gastrointestinal bleeding