title: Infants of opioid-dependent mothers: neurodevelopment at six months.
abstract: OBJECTIVE
  The aim of this study is to describe infant neurodevelopment in 81 infants of methadone-prescribed opioid-dependent mothers.
  
  
  METHODS
  Griffith MD scores at six months.
  
  
  RESULTS
  Scores were lower in all domains compared to controls (p<0.001). Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0.002 and p=0.008 respectively).
  
  
  CONCLUSIONS
  Infants of methadone-maintained opioid-dependent mothers show poorer neurodevelopment at six months of age than non-drug exposed comparison infants. Developmental difficulties are confounded by delayed visual development.
  
  
  CONCLUSIONS
  These highly vulnerable children merit close surveillance throughout infancy.
  
  
  CONCLUSIONS
  Griffith MD scores at six months in 81 infants born to methadone-prescribed opioid-dependent mothers were lower in all domains compared to controls (p<0.001). Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0.002 and p=0.008 respectively). Co-existing visual problems were common.
authors.affiliation: Southern General Hospital and the Royal Hospital for Sick Children, Dalnair Street, Yorkhill, Glasgow G3 8SJ, United Kingdom. Electronic address: lauramcglone@doctors.org.uk.
authors.forename: Laura
authors.initials: L
authors.lastname: McGlone
authors.affiliation: Princess Royal Maternity, 8-16, Alexandra Parade, Glasgow G31 2ER, United Kingdom. Electronic address: helen.mactier@ggc.scot.nhs.UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Mactier
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects; D016022:Case-Control Studies; D002657:Child Development; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008691:Methadone / Q000627:therapeutic use; D009357:Neonatal Abstinence Syndrome / Q000175:diagnosis*; D058850:Opiate Substitution Treatment; D009293:Opioid-Related Disorders / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis*; D014786:Vision Disorders / Q000175:diagnosis*
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone
keywords: Drug misuse; Griffiths score; Methadone; Neurodevelopment