title: Is bioavailability altered in generic versus brand anticonvulsants?
abstract: Therapeutic window of anticonvulsants is not a wide one, with phenytoin being one extreme, which can be classified as a narrow therapeutic index drug, since its ratio between the least toxic and the least effective concentration is less than twofold. In order to obtain marketing authorization, a generic anticonvulsant should demonstrate relative bioequivalence with its brand-name counterpart. However, although bioequivalent, generic anticonvulsants still do not have the same bioavailability as brand-name drugs, which may lead to larger fluctuations of steady-state plasma concentrations, and sometimes to loss of seizure control if a patient is switched from brand-name to generic or from generic to generic anticonvulsant. Generic anticonvulsants are effective, safe and affordable drugs for treatment of epilepsy, and patients could be successfully treated with them from the very beginning. It is switching from brand-name to generic anticonvulsant or from one generic anticonvulsant to another that should be avoided in clinical practice, since subtle differences in bioavailability may disturb optimal degree of seizure control to which the patient was previously successfully titrated.
authors.affiliation: University of Kragujevac, Faculty of Medical Sciences , SvetozaraMarkovica Street, 30, 34000 Kragujevac , Serbia.
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Jankovic
authors.forename: Dragana
authors.initials: D
authors.lastname: Ignjatovic Ristic
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D001682:Biological Availability; D017277:Drug Approval; D016568:Drugs, Generic / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D013810:Therapeutic Equivalency
chemical_list: D000927:Anticonvulsants; D016568:Drugs, Generic
keywords: anticonvulsants; bioavailability; bioequivalence; interchangeability