title: Combined effect of selected mineral fibres and tobacco smoke on respiratory tract in rats.
abstract: The rats were inhaling amosite and wollastonite fibres at two concentrations (30 and 60 mg/m3) one hour every second day and cigarette smoke of 3 cigarettes per day (with the exception of Saturdays and Sundays). They were sacrificed after 6 month of exposure. Bronchoalveolar lavage (BAL) was performed and selected inflammatory and cytotoxic parameters were examined. Amosite: inflammatory parameters were the most changed after 60 mg/m3 in both groups with or without smoking; the cytotoxic parameters were strongly influenced by smoking. Wollastonite (asbestos substitute) inhalation confirmed lower inflammatory and cytotoxic effects on all examined animal groups in comparison with amosite.
authors.forename: Marta
authors.initials: M
authors.lastname: Hurbánková
authors.forename: Dominika
authors.initials: D
authors.lastname: Hraškov
authors.forename: Milan
authors.initials: M
authors.lastname: Beňo
authors.forename: Silvia
authors.initials: S
authors.lastname: Černa
authors.forename: Soňa
authors.initials: S
authors.lastname: Wimmerova
authors.forename: Štefánia
authors.initials: Š
authors.lastname: Moricová
mesh_terms: D000818:Animals; D017639:Asbestos, Amosite / Q000633:toxicity*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D017610:Calcium Compounds / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D019016:Mineral Fibers / Q000633:toxicity*; D051381:Rats; D012137:Respiratory System / Q000166:cytology*; D017640:Silicates / Q000633:toxicity*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D017610:Calcium Compounds; D018836:Inflammation Mediators; D019016:Mineral Fibers; D017640:Silicates; D014028:Tobacco Smoke Pollution; D017639:Asbestos, Amosite; C031293:calcium silicate