title: Association between ABO blood group and osteoporosis among postmenopausal women of North India.
abstract: The present study is an attempt to examine possible associations between ABO blood groups and the risk of osteoporosis among postmenopausal women of North India. This cross-sectional study involved 250 postmenopausal women from North India, ranging in age from 45 to 80 years. Four anthropometric measurements (height, weight, waist circumference and hip circumference), blood sample (ABO status and haemoglobin concentration) and grip strength (dominant as well as non-dominant hand) of all the participants were taken. Bone mineral density (BMD) was evaluated by using dual energy X-ray absorptiometry (DXA) at lumbar spine (L1-L4) and proximal femur. Analysis of data revealed that at lumbar spine (L1-L4) osteoporosis was more prevalent among individuals with blood group A (31.58%), followed by those with blood group B (29.67%), AB (28.57%) and then blood group O (15%), whereas for proximal femur individuals with blood group AB (21.43%) showed the highest prevalence of osteoporosis followed by a decreasing trend from blood group A (17.54%) to B (12.08%) and then O (5%). Total prevalence of osteoporosis was 26.4% in lumbar spine and 13.2% in proximal femur, indicating that lumbar spine had an elevated risk for osteoporosis among postmenopausal women. All the anthropometric variables, haemoglobin concentration as well as grip strength of individuals with blood group O demonstrated non-significant differences with non-O blood group except for weight and body mass index, where differences were statistically significant. Women with blood group O exhibited significantly higher bone mineral density for lumbar spine (0.90 g/cm(2) vs. 0.85 g/cm(2), p<0.05) and proximal femur (0.87 g/cm(2) vs. 0.79 g/cm(2), p<0.05) as compared to those with non-O blood group, thereby suggesting an increasing risk of osteoporosis among individuals with non-O blood group.
authors.affiliation: Department of Anthropology, Panjab University, Chandigarh, India. Electronic address: maninderkaur_1@yahoo.in.
authors.forename: Maninder
authors.initials: M
authors.lastname: Kaur
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood* / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System