title: Novel markers predict death and organ failure following hemorrhagic shock.
abstract: BACKGROUND
  ADAMTS 13, sP-Selectin and HSP27 have been investigated as potential prognostic markers in patients with hemorrhagic shock.
  
  
  METHODS
  This study was part of a double-blind, randomized, parallel-group, controlled trial and included seventeen trauma patients presented to ED with severe hemorrhagic. The sera for testing were collected from these patients at the time of admission. Investigators and laboratory personnel performing testing were blinded to the patients' identity and clinical course.
  
  
  RESULTS
  The prognostic value of ADAMTS13, sP-Selectin, and HSP27 was compared to prognostic value of systolic blood pressure (SBP), base deficit estimation (BD), heart rate (HR), shock index (SI) and tissue oxygen saturation (StO2) by constructing the receiver operation characteristics (ROC). The area under the curve (AUC) of the ROC for HSP27 (0.92) was greater than for SBP (0.45), BD (0.89), HR (0.61), SI (0.45) and StO2 (0.46). AUC for sP-Selectin (0.86) and for ADAMTS13 antigen (0.74) were comparable with BD one, but greater than for the rest of currently used tests.
  
  
  CONCLUSIONS
  Serum concentrations of ADAMTS13, HSP27 and sP-Selectin measured during the admission, appear to be comparable to or better than SBP, BD, SI, HR and StO2 in predicting MODS and death after hemorrhage from trauma. These potential new markers deserve further investigation.
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States. Electronic address: furmaga@uthscsa.edu.
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Furmaga
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Stephen
authors.initials: S
authors.lastname: Cohn
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Prihoda
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Muir
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Valery
authors.initials: V
authors.lastname: Mikhailov
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Janet
authors.initials: J
authors.lastname: McCarthy
authors.affiliation: Department of Pathology, University Texas Health Science Center at San Antonio, 7704 Floyd Curl Drive, San Antonio, TX, United States.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Arar
mesh_terms: D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D001794:Blood Pressure; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000097:blood; D006339:Heart Rate; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009102:Multiple Organ Failure / Q000401:mortality* / Q000503:physiopathology*; D019007:P-Selectin / Q000097:blood; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D019007:P-Selectin; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
keywords: ADAMTS13; HSP27; Hemorrhagic shock; Hemorrhagic shock markers; Multi-organ failure; sP-Selectin