title: Prediction of long-term outcome after acute myocardial infarction using circulating miR-145.
abstract: BACKGROUND
  Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating miR-145 concentration.
  
  
  METHODS
  We assessed 246 patients with first ST-segment-elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured circulating miR-145, N-terminal fragment of the precursor B-type natriuretic peptide, myocardial-band creatine kinase, and cardiac troponin-I concentrations on day 5 after primary percutaneous coronary intervention and assessed their correlations with long-term clinical outcome.
  
  
  RESULTS
  During the one-year follow-up period, 72 patients experienced primary composite cardiac events (cardiac death or hospitalization for worsening heart failure). Multivariable Cox proportional hazards analysis indicated that circulating miR-145 (hazard ratio 7.174, 95% confidence interval 4.208-12.229); p < 0.0001) was a significant independent predictor of cardiac events after adjustment for multiple confounders.
  
  
  CONCLUSIONS
  Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction.
authors.affiliation: Department of Cardiology, Center for Atrial Fibrillation, Beijing Anzhen Hospital, Capital Medical University , Beijing.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Dong
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Liu
authors.forename: Guo-Qian
authors.initials: GQ
authors.lastname: Wei
authors.forename: Ying-Nan
authors.initials: YN
authors.lastname: Da
authors.forename: Li
authors.initials: L
authors.lastname: Cha
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Ma
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016016:Proportional Hazards Models; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C541010:MIRN145 microRNA, human; D035683:MicroRNAs
keywords: Heart failure; acute myocardial infarction; biomarker; cardiac death; miR-145