title: Comparison of peak flow velocity through the left ventricular outflow tract and effective orifice area indexed to body surface area in Golden Retriever puppies to predict development of subaortic stenosis in adult dogs.
abstract: OBJECTIVE
  To evaluate the usefulness of Doppler-derived peak flow velocity through the left ventricular outflow tract (LVOT Vmax) and effective orifice area indexed to body surface area (EOAi) in puppies to predict development of subaortic stenosis (SAS) in the same dogs as adults.
  
  
  METHODS
  Prospective, longitudinal, observational study.
  
  
  METHODS
  38 Golden Retrievers.
  
  
  METHODS
  Cardiac auscultation and echocardiography were performed on 2- to 6-month-old puppies, then repeated at 12 to 18 months. Subaortic stenosis was diagnosed when LVOT Vmax was ≥ 2.3 m/s in adult dogs with left basilar systolic murmurs.
  
  
  RESULTS
  All puppies with EOAi < 1.46 cm(2)/m(2) had SAS as adults. All adults with EOAi < 1.29 cm(2)/m(2) had SAS. An LVOT Vmax > 2.3 m/s in puppyhood was 63% sensitive and 100% specific for SAS in adulthood. In puppies, LVOT Vmax was more strongly associated with a future diagnosis of SAS (area under the curve [AUC], 0.89) than was EOAi (AUC, 0.80). In puppies, the combination of LVOT Vmax and EOAi yielded slightly higher sensitivity (69%) and specificity (100%) for adult SAS than did LVOT Vmax alone. In unaffected and affected dogs, LVOT Vmax increased significantly from puppyhood to adulthood but EOAi did not.
  
  
  CONCLUSIONS
  In Golden Retriever puppies, LVOT Vmax > 2.3 m/s and EOAi < 1.46 cm(2)/m(2) were both associated with a diagnosis of SAS at adulthood. The combination of these 2 criteria may result in higher sensitivity for SAS screening. Unlike LVOT Vmax, EOAi did not change during growth in either unaffected Golden Retrievers or those with SAS.
authors.affiliation: Companion Animal Research Group, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC J2S 7C6, Canada.
authors.forename: Romain
authors.initials: R
authors.lastname: Javard
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Bélanger
authors.forename: Etienne
authors.initials: E
authors.lastname: Côté
authors.forename: Guy
authors.initials: G
authors.lastname: Beauchamp
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001830:Body Surface Area / Q000662:veterinary*; D021922:Discrete Subaortic Stenosis / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D008297:Male