title: Quality of life before and after laparoscopic sleeve gastrectomy. A prospective cohort study.
abstract: BACKGROUND
  There is a lack of adequate prospective data on quality-of-life (QOL) and its predictors in patients undergoing laparoscopic sleeve gastrectomy (LSG). The aim of this study was to assess longitudinal changes in QOL after LSG with the use of the obesity-specific Moorehead-Ardelt II questionnaire (MAII) and to identify clinical parameters associated with QOL outcome.
  
  
  METHODS
  Morbidly obese patients consecutively admitted for LSG, over a 30-month period, were prospectively studied. QOL was assessed using the validated Greek version of the MAII questionnaire and a visual analogueue scale (VAS), preoperatively and at 6, 12, and 24 months postoperatively. Anthropometric data and obesity-related co-morbidities were recorded.
  
  
  RESULTS
  A total of 111 patients with a mean age 36.8±9.2 years were included. Mean preoperative body mass index (BMI) was 49.1±7.5 kg/m2. Percentage excess BMI loss (%EBL) was 51.1±14.9, 64.2±17.9 and 66.4±18.0 at 6, 12, and 24 months, respectively. Postoperatively, all obesity-related co-morbidities were significantly improved. MAII score increased from -.40±1.30 preoperatively to 1.75±.83, 2.18±.80, and 1.95±.71 at 6, 12, and 24 months postoperatively (trend P<.001). Preoperative median (interquartile range) VAS was 3 (1) increasing to 9 (2), 10 (1), and 9 (1) at 6, 12, and 24 months postoperatively (P<.001). %EBL and reduction in obesity-related co-morbidities, especially resolution of diabetes and sleep apnea, correlated significantly with higher QOL during the course of the study.
  
  
  CONCLUSIONS
  LSG, a safe and effective bariatric operation, results in sustained weight loss and significant improvements in QOL. Both weight loss and amelioration of co-morbidities contribute to higher level of postsurgical QOL.
authors.affiliation: Bariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, University of Crete, Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Charalampakis
authors.affiliation: Rheumatology-Clinical Immunology, Heraklion University Hospital, University of Crete, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Bertsias
authors.affiliation: Bariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, University of Crete, Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Lamprou
authors.affiliation: Bariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, University of Crete, Greece.
authors.forename: Eelco
authors.initials: E
authors.lastname: de Bree
authors.affiliation: Bariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, University of Crete, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Romanos
authors.affiliation: Bariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, University of Crete, Greece. Electronic address: melissas@med.uoc.gr.
authors.forename: John
authors.initials: J
authors.lastname: Melissas
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000704:Analysis of Variance; D050110:Bariatric Surgery / Q000379:methods / Q000523:psychology; D005260:Female; D005743:Gastrectomy / Q000379:methods / Q000523:psychology*; D006801:Humans; D007398:Interpersonal Relations; D010535:Laparoscopy / Q000379:methods / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000523:psychology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D011788:Quality of Life; D012649:Self Concept; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Bariatric surgery; Moorehead-Ardelt II questionnaire; Quality of life; Sleeve gastrectomy