title: Absorption efficiency and heating kinetics of nanoparticles in the RF range for selective nanotherapy of cancer.
abstract: Radio-frequency (RF) waves have an excellent ability to penetrate into the human body, giving a great opportunity to activate/heat nanoparticles delivered inside the body as a contrast agent for diagnosis and treatment purposes. However the heating of nanoparticles in the RF range of the spectrum is controversial in the research community because of the low power load of RF waves and low absorption of nanoparticles in the RF range. This study uses a phenomenological approach to estimate the absorption efficiency of metal and dielectric nanoparticles in the RF range through a study of heating kinetics of those particles in radio wave field. We also discuss the specific features of heating kinetics of nanoparticles, such as a short time scale for heating and cooling of nanoparticles in a liquid biological environment, and the effect of the radiation field structure on the heating kinetics by single-pulse and multipulse RF radiation.
  
  
  BACKGROUND
  In this study a phenomenological approach was applied to estimate the absorption efficiency of radiofrequency radiation (RF) by metal and dielectric nanoparticles. Such nanoparticles can be designed and used for therapeutic purposes, like for localized heating and to activate nanoparticles by RF. The authors also discuss the differences in heating kinetics using single-pulse and multi-pulse RF radiation.
authors.affiliation: Department of Physics and Optical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN, USA. Electronic address: letfullin@rose-hulman.edu.
authors.forename: Renat R
authors.initials: RR
authors.lastname: Letfullin
authors.affiliation: Department of Physics and Optical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN, USA.
authors.forename: Alla R
authors.initials: AR
authors.lastname: Letfullin
authors.affiliation: Office of the Chancellor and Center for Nanoscience, Departments of Chemistry & Biochemistry and Physics & Astronomy, University of Missouri-St. Louis, St. Louis, MO, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: George
mesh_terms: D006361:Heating; D006801:Humans; D007700:Kinetics; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000528:radiation effects; D050997:Nanomedicine; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011846:Radio Waves
keywords: Cancer treatment; Nanoparticle RF heating