title: As time goes by: KRABs evolve to KAP endogenous retroelements.
abstract: Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 and SVA retrotransposons in humans, highlighting the evolutionary interplay between retroelements and their hosts.
authors.affiliation: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Imbeault
authors.affiliation: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: didier.trono@epfl.ch.
authors.forename: Didier
authors.initials: D
authors.lastname: Trono
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D011323:Primates / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; D018626:Retroelements