title: Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers.
abstract: We have investigated the in vitro anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta flower extracts. We used the HPLC technique to purify the flavonoid (quercetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside) and two phenylpropanoid glycosides (verbascoside and isoverbascoside); we evaluated the antimicrobial activity of the extracts against Candida strains (Candidaalbicans; Candidakrusei ATCC 6258; and the clinical isolate strains of Candida sp. C. albicans, C. krusei, Candidatropicalis, Candidaparapsilosis, and Candidaguilhermondii). The P. venusta flower extracts displayed antimicrobial and antioxidant activities. The semi-purified fraction of the P. venusta flower extract and the phenylpropanoid glycoside verbascoside exhibited activity similar to that of amphotericin B, which denoted that they are potentially applicable as natural antioxidant and anticandidal agents in the pharmaceutical industries.
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil. Electronic address: apereira@unaerp.br.
authors.forename: Ana Maria S
authors.initials: AM
authors.lastname: Pereira
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Hernandes
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Sarazete I V
authors.initials: SI
authors.lastname: Pereira
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Bianca W
authors.initials: BW
authors.lastname: Bertoni
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Suzelei C
authors.initials: SC
authors.lastname: França
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Paulo S
authors.initials: PS
authors.lastname: Pereira
authors.affiliation: Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Av. Costábile Romano, 2201, CEP 14096-900 Ribeirão Preto, SP, Brazil.
authors.forename: Silvia H
authors.initials: SH
authors.lastname: Taleb-Contini
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D002175:Candida / Q000187:drug effects*; D004186:Disaccharidases / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004357:Drug Synergism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006860:Hydrogen Bonding; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D059808:Polyphenols
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D004186:Disaccharidases; D005960:Glucosides; D010636:Phenols; D011794:Quercetin; C000614158:quercetin-3-O-rhamnopyranosyl-(1-6)-galactopyranoside; C058956:acteoside; D059808:Polyphenols; C064683:isoacteoside
keywords: Antimicrobial activity; Bignoniaceae; Cerrado; Phytotherapy; Verbascoside