title: (11)C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer.
abstract: To assess the diagnostic usefulness of (11)C-choline PET/CT vs. multi-parametric MRI in the prostate cancer relapse. A retrospective study of 21 patients with prostate cancer treated initially with surgery (n=12), radiotherapy (n=9). PSA levels were increased (post-surgery: .3-3.6 ng/ml; post-radiotherapy: 2.4-8.8 ng/ml). In an interval of time of 15 days all patients were underwent to: whole-body-dual-modality PET-CT carried out early after (11)C-choline (296 ± 29 MBq) injection, and multiparametric prostate MRI with paramagnetic intravenous contrast (using anatomical imaging sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging). On the basis of our results, all patients were underwent to directed diagnosis and/or clinical, analytic and imaging follow-up. In 15 patients (71.4%) both procedures showed concordant results: 4 negative and 11 positive cases [7 local recurrences, 3 isolated pelvic lymph nodes (2 infracentimetric), 1 local relapse and only one M1 bone metastases]. The results were discordant in 6 patients (28.6%): 3 local relapses in MRI with no PET significance, 1 local relapse in PET with no MRI significance. 2 bone metastases were identified with PET (out of the field-of-view of MRI).
  
  
  CONCLUSIONS
  (11)C-choline PET/CT and multi-parametric MRI play a complementary role in the detection of local relapse in prostate cancer patients, with similar sensitivity for the detection of lymph involvement. Whole-body 11C-choline PET/CT technique is also useful for bone staging.
authors.affiliation: Unidad PET/TC, CETIR, España. Electronic address: jrgarcia@cetir.es.
authors.forename: J R
authors.initials: JR
authors.lastname: Garcia
authors.affiliation: Servicio de Radiología, Centro Médico Teknon, Barcelona, España.
authors.forename: N
authors.initials: N
authors.lastname: Romera
authors.affiliation: Unidad PET/TC, CETIR, España.
authors.forename: M
authors.initials: M
authors.lastname: Cozar
authors.affiliation: Unidad PET/TC, CETIR, España.
authors.forename: M
authors.initials: M
authors.lastname: Soler
authors.affiliation: Unidad PET/TC, CETIR, España.
authors.forename: M
authors.initials: M
authors.lastname: Moragas
authors.affiliation: Servicio de Radiología, Centro Médico Teknon, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Escobar
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000556:secondary / Q000628:therapy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002250:Carbon Radioisotopes; D002794:Choline; D003131:Combined Modality Therapy; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D019275:Radiopharmaceuticals; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D017430:Prostate-Specific Antigen; D002794:Choline
keywords: (11)C-choline positron emission tomography/computed tomography; (11)C-colina tomografía por emisión de positrones/tomografía computarizada; Biochemical relapse; Cáncer de próstata; Multiparametric magnetic resonance imaging; Prostate cancer; Recidiva bioquímica; Resonancia magnética multiparamétrica