title: A lignin glycoside and a nortriterpenoid from Kadsura coccinea.
abstract: OBJECTIVE
  To study the chemical constituents of the roots and stem bark of Kadsura coccinea.
  
  
  METHODS
  Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS.
  
  
  RESULTS
  Two compounds were determined as (7'S,8'S,8R)-(8β,8'α)-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside (1) and micrandiactone H (2), respectively.
  
  
  CONCLUSIONS
  Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Amorepacific Shanghai R & I Center, Shanghai 201801, China.
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Yeon
authors.affiliation: State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Amorepacific Shanghai R & I Center, Shanghai 201801, China.
authors.forename: Quan-Quan
authors.initials: QQ
authors.lastname: He
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032135:Kadsura / Q000737:chemistry*; D008031:Lignin / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D009569:Nitric Oxide; D008031:Lignin
keywords: Kadsura coccinea; Lignan glucoside; Schisandraceae; Triterpenoid