title: Mid-term outcomes in patients following transcatheter aortic valve implantation in the CoreValve Australia and New Zealand Study.
abstract: BACKGROUND
  Although numerous studies have reported the safety and effectiveness of transcatheter aortic valve implantation (TAVI), integration of this therapy into standard of care varies widely by region. We evaluated mid-term follow-up in 540 patients with severe symptomatic AS at high risk of surgical AV replacement, enrolled in the ongoing Medtronic CoreValve Australia-New Zealand Study.
  
  
  METHODS
  Between August 2008 and July 2013, 10 centres in Australia/New Zealand enrolled 540 patients, which includes initial use of the CoreValve System for all investigators. Patients were deemed suitable for TAVI based on consensus of a multidisciplinary Heart Team. Primary endpoints were cardiovascular death and major adverse cardiovascular and cerebrovascular events (MACCE) at 30 days. Data were fully monitored, and an independent Clinical Events Committee employed.
  
  
  RESULTS
  Baseline characteristics include; 45% female, mean age 84 years, EuroSCORE 17.3±10.7%, and 74.9% had New York Heart Association III/IV symptoms. At 30 days, all deaths were cardiovascular (4.1%); MACCE was 11.5%. At one and two years, all-cause mortality was 11.9% and 21.2%; cardiovascular mortality, 9.9% and 15.2%; and stroke, 8.2% and 10.1%, respectively.
  
  
  CONCLUSIONS
  Early experience with the CoreValve System in a large cohort of fully-monitored patients was associated with good early- and mid-term safety outcomes.
authors.affiliation: MonashHeart and Monash University, Melbourne, Australia. Electronic address: ian.meredith@myheart.id.au.
authors.forename: Ian T
authors.initials: IT
authors.lastname: Meredith
authors.affiliation: Alfred Hospital, Melbourne, Australia; Epworth Healthcare, Melbourne, Australia.
authors.forename: Antony
authors.initials: A
authors.lastname: Walton
authors.affiliation: Prince Charles Hospital, Brisbane, Australia.
authors.forename: Darren L
authors.initials: DL
authors.lastname: Walters
authors.affiliation: Waikato Hospital, Hamilton, New Zealand.
authors.forename: Sanjeevan
authors.initials: S
authors.lastname: Pasupati
authors.affiliation: St. Vincent's Sydney, Sydney, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Muller
authors.affiliation: Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Worthley
authors.affiliation: Royal Perth Hospital, Perth, Australia.
authors.forename: Gerald
authors.initials: G
authors.lastname: Yong
authors.affiliation: St. Vincent's Hospital, Melbourne, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Whitbourn
authors.affiliation: Alfred Hospital, Melbourne, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Duffy
authors.affiliation: Mercy Hospital, Auckland, New Zealand.
authors.forename: John
authors.initials: J
authors.lastname: Ormiston
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009520:New Zealand; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000401:mortality; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000379:methods*
keywords: Aortic stenosis; Outcomes; Percutaneous; Registry; Self-expanding transcatheter heart valve; Transcatheter aortic valve implantation