title: Association of hyper-LDL cholesterolemia with increased risk of colorectal adenoma.
abstract: OBJECTIVE
  Previous studies on the association between dyslipidemia and the presence of colorectal adenoma showed conflicting results, and were limited due to small sample sizes, inconsistent definitions of dyslipidemia, or a lack of data on full lipid profiles. The aim of this study was to determine the association between colorectal adenomas and dyslipidemia according to the definition by the National Cholesterol Education Program- Adult Treatment Panel III.
  
  
  METHODS
  We conducted a retrospective, cross-sectional study in subjects who underwent screening colonoscopy and blood tests for full lipid profiles. Serum dyslipidemia profiles were compared between the adenoma group and the control group, and multivariate analysis was performed to identify independent predictors of the presence of colorectal adenomas.
  
  
  RESULTS
  Patients with hyper-LDL cholesterolemia were more frequently included in the adenoma group than the control group (46.7% vs. 32.1%, respectively, p=0.023), and hyper-LDL cholesterolemia (OR = 1.954, 95% CI=0.981-3.893, p=0.057) showed a statistical trend for the positive association with the presence of colorectal adenomas by multivariate analysis. Furthermore, proximal colorectal adenomas were more prevalent in the hyper-LDL cholesterolemia group than in the normal LDL cholesterolemia group (p=0.026).
  
  
  CONCLUSIONS
  Hyper-LDL cholesterolemia was associated with the presence of colorectal adenomas, especially in the proximal colon.
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Hong
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Cha
authors.forename: Joung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.forename: Hyun Phil
authors.initials: HP
authors.lastname: Shin
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Jeun
authors.forename: Jun Uk
authors.initials: JU
authors.lastname: Lim
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D008078:Cholesterol, LDL / Q000097:blood*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL