title: Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia.
abstract: OBJECTIVE
  To evaluate whether ramosetron increases the corrected QT (QTc) interval.
  
  
  METHODS
  Prospective, randomized, controlled study.
  
  
  METHODS
  Operating room.
  
  
  METHODS
  135 patients undergoing elective laparoscopic cholecystectomy.
  
  
  METHODS
  Patients were allocated to three groups to receive ondansetron 4 mg (Group O4), ramosetron 0.3 mg (Group R), or ondansetron 8 mg (Group O8). The study drugs were administered intravenously approximately 15 minutes before the end of surgery.
  
  
  METHODS
  The QT interval for 10 minutes after administration was recorded. The QTc interval was calculated according to the Fridericia (QTcF) formula. The primary outcome was the QTcF interval among the three groups during the 10 minutes after administration of the study drugs.
  
  
  RESULTS
  The QTcF interval was not significantly prolonged after administration of ondansetron 4 mg and ramosetron. It was significantly increased from one minute after administration until 7 minutes after ondansetron 8 mg (Group O8). The QTcF interval was significantly longer in Group O8 at 1, 2, 3, 4, and 5 minutes.
  
  
  CONCLUSIONS
  The prophylactic administration 0.3 mg of ramosetron does not increase the QTc interval. Ondansetron 8 mg increases the QTc interval more so than 4 mg of ondansetron.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea. Electronic address: skim@schmc.ac.kr.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Su-Myung
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Young-Kwon
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Soon Chun Hyang University Hospital, 657 Hannam-dong, Yongsan-gu, Seoul 140-210, South Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Chai
authors.affiliation: Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: Hee-Cheol
authors.initials: HC
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods; D000932:Antiemetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017081:Cholecystectomy, Laparoscopic; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D017294:Ondansetron / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000932:Antiemetics; D001562:Benzimidazoles; D017294:Ondansetron; C071315:ramosetron
keywords: Laparoscopic cholecystectomy; Ondansetron; Postoperative nausea and vomiting; QT interval; QTc interval; Ramosetron