title: Kinetic release studies of nitrogen-containing bisphosphonate from gum acacia crosslinked hydrogels.
abstract: Natural polymer hydrogels are useful for controlling release of drugs. In this study, hydrogels containing gum acacia were synthesized by free-radical polymerization of acrylamide with gum acacia. The effect of gum acacia in the hydrogels on the release mechanism of nitrogen-containing bisphosphonate (BP) was studied at pH 1.2 and 7.4. The hydrogels exhibited high swelling ratios at pH 7.4 and low swelling ratios at pH 1.2. The release study was performed using UV-Visible spectroscopy via complex formation with Fe(III) ions. At pH 1.2, the release profile was found to be anomalous while at pH 7.4, the release kinetic of BP was a perfect zero-order release mechanism. The hydrogels were found to be pH-sensitive and the release profiles of the BP were found to be influenced by the degree of crosslinking of the hydrogel network with gum acacia. The preliminary results suggest that these hydrogels are promising devices for controlled delivery of bisphosphonate to the gastrointestinal region.
authors.affiliation: Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, South Africa. Electronic address: blessingaderibigbe@gmail.com.
authors.forename: B A
authors.initials: BA
authors.lastname: Aderibigbe
authors.affiliation: Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa; Centre de Investigación de Polimeros Avanzados, CIPA, Beltràn Mathieu 224, piso 2, Concepción, Chile.
authors.forename: K
authors.initials: K
authors.lastname: Varaprasad
authors.affiliation: Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa.
authors.forename: E R
authors.initials: ER
authors.lastname: Sadiku
authors.affiliation: DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa; Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.
authors.forename: S S
authors.initials: SS
authors.lastname: Ray
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.
authors.forename: X Y
authors.initials: XY
authors.lastname: Mbianda
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.
authors.forename: M C
authors.initials: MC
authors.lastname: Fotsing
authors.affiliation: Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa.
authors.forename: S J
authors.initials: SJ
authors.lastname: Owonubi
authors.affiliation: Department of Chemical, Metallurgical and Material Engineering, Tshwane University of Technology, Pretoria 0001, South Africa.
authors.forename: S C
authors.initials: SC
authors.lastname: Agwuncha
mesh_terms: D004164:Diphosphonates / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006170:Gum Arabic / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D004164:Diphosphonates; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D006170:Gum Arabic; D009584:Nitrogen
keywords: Bisphosphonate; Gum acacia.; Hydrogel