title: Diffusion tensor imaging for brain malformations: does it help?
abstract: In this article, the basics of diffusion-weighted imaging/diffusion tensor imaging (DTI) are discussed, including a short historical perspective on the fiber dissection technique, followed by a review of selected brain malformations in which DTI and tractography have contributed to a better understanding of the malformations, and by a clinical case in which DTI showed a disorder of the internal neuroarchitecture that could not be correctly appreciated by conventional anatomic magnetic resonance imaging.
authors.affiliation: Section of Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Charlotte R. Bloomberg Children's Center, The Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD 21287-0842, USA. Electronic address: thuisma1@jhmi.edu.
authors.forename: Thierry A G M
authors.initials: TA
authors.lastname: Huisman
authors.affiliation: Section of Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Charlotte R. Bloomberg Children's Center, The Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD 21287-0842, USA.
authors.forename: Thangamadhan
authors.initials: T
authors.lastname: Bosemani
authors.affiliation: Section of Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Charlotte R. Bloomberg Children's Center, The Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD 21287-0842, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Poretti
mesh_terms: D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066127:White Matter / Q000002:abnormalities* / Q000473:pathology*
keywords: Axonal guidance disorders; Brain malformations; Children; Diffusion tensor imaging; Fiber tractography; Neuroimaging