title: Both volumetry and functional connectivity of Heschl's gyrus are associated with auditory P300 in first episode schizophrenia.
abstract: BACKGROUND
  Reduced gray matter volume in left superior temporal gyrus (STG) is considered to be associated with auditory P300 amplitude in schizophrenia. Little is known about possible pathological circuits regarding sub-regions of STG that contribute to auditory P300 abnormality in schizophrenia. The current study investigated gray matter volume in STG and functional connectivity of Heschl's gyrus in first-episode schizophrenia (FESZ), as well as their correlations with P300 amplitude.
  
  
  METHODS
  Nineteen FESZ patients and 19 healthy controls contributed MRI scans. Eighteen patients and 17 controls underwent auditory P300 test within 1 week after MRI scanning. STG structural abnormalities were analyzed using voxel-based morphometry (VBM) analysis. Bilateral Heschl's gyri (HG) were selected as seeds for FC analysis in resting MRI data. Correlations of P300 amplitude with gray matter alterations in STG and HG-based FC were analyzed using Pearson correlation analysis within each group.
  
  
  RESULTS
  Compared to healthy controls, FESZ patients showed reduced gray matter in left STG and P300 amplitude. Gray matter volume of left Heschl's gyrus was positively correlated with P300 amplitude in FESZ patients. HG-based FC of resting fMRI was decreased in the inferior frontal gyrus (IFG), medial frontal gyrus (MFG), anterior cingulate cortex (ACC), and left temporal pole, whereas the same metric was increased in the lingual gyrus, precuneus and cerebellar tonsil among FESZ patients. FC between bilateral HG and precuneus was inversely correlated with P300 amplitude among healthy controls, and was absent among FES patients.
  
  
  CONCLUSIONS
  The findings point towards both decreased volume of Heschl's gyrus and its altered functional pathways may contribute to auditory P300 abnormality in schizophrenia.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Tianhong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Physics, East China Normal University, Shanghai 200062, China.
authors.forename: Jianqi
authors.initials: J
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Dengtang
authors.initials: D
authors.lastname: Liu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China. Electronic address: Jijunwang27@gmail.com.
authors.forename: Jijun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D066128:Gray Matter / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009929:Organ Size; D012146:Rest; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D055815:Young Adult
keywords: Auditory P300; First-episode schizophrenia; Functional connectivity; Heschl's gyrus; Precuneus; Superior temporal gyrus