title: Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is an extremely prevalent cause of dementia. It is characterized by progressive memory loss, confusion, and other behavioral and physiological problems. The amyloid-β (Aβ) protein is thought to be involved in the pathogenesis of AD, and there is evidence that Aβ may act through the p75 neurotrophin receptor (p75) to mediate its pathogenic effects. This raises the possibility that reducing levels of p75 could be a treatment for AD by preventing the effects of Aβ. In this study, we have crossed the transgenic AD model mice, Tg2576, with p75(-/-) mice to generate Tg2576/p75(+/-) mice with reduced levels of p75. These mice are rescued from the deficits in learning and memory and hippocampal function which were found in the Tg2576 mice. These findings suggest that reduction of p75 can ameliorate some of the primary symptoms of AD.
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: m.murphy@unimelb.edu.au.
authors.forename: Mark
authors.initials: M
authors.lastname: Murphy
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Yvette M
authors.initials: YM
authors.lastname: Wilson
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Vargas
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Munro
authors.affiliation: Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Belinda
authors.initials: B
authors.lastname: Smith
authors.affiliation: Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Amy
authors.initials: A
authors.lastname: Huang
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Qiao-Xin
authors.initials: QX
authors.lastname: Li
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Junhua
authors.initials: J
authors.lastname: Xiao
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Reid
authors.affiliation: Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Barrett
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007858:Learning; D008297:Male; D008568:Memory; D008822:Mice, Transgenic; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism* / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D017475:Receptors, Nerve Growth Factor; C517634:Ngfr protein, mouse
keywords: Alzheimer's disease; Memory; p75 neurotrophin receptor