title: Choroid plexus in developmental and evolutionary perspective.
abstract: The blood-cerebrospinal fluid boundary is present at the level of epithelial cells of the choroid plexus. As one of the sources of the cerebrospinal fluid (CSF), the choroid plexus (CP) plays an important role during brain development and function. Its formation has been studied largely in mammalian species. Lately, progress in other model animals, in particular the zebrafish, has brought a deeper understanding of CP formation, due in part to the ability to observe CP development in vivo. At the same time, advances in comparative genomics began providing information, which opens a possibility to understand further the molecular mechanisms involved in evolution of the CP and the blood-cerebrospinal fluid boundary formation. Hence this review focuses on analysis of the CP from developmental and evolutionary perspectives.
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles Los Angeles, CA, USA.
authors.forename: Brent Roy
authors.initials: BR
authors.lastname: Bill
authors.affiliation: Agency for Science, Technology and Research of Singapore, Institute of Molecular and Cell Biology Singapore, Singapore ; National University of Singapore, Department of Biological Sciences Singapore, Singapore.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Korzh
keywords: brain-CSF; epithelium; glia; stroma; transgenics; vasculature