title: Heartworm 'lack of effectiveness' claims in the Mississippi delta: computerized analysis of owner compliance--2004-2011.
abstract: A retrospective medical record review was conducted to identify factors from veterinary clinic medical records that may have contributed to suspected ineffectiveness of a heartworm preventive product. Patient records of 271 dogs, comprising 301 instances of positive heartworm antigen test results while the dogs were receiving heartworm preventive were evaluated. Nineteen veterinary practices in 17 counties and parishes in Arkansas, Louisiana, Mississippi, and Tennessee participated in the study. Records were selected by the veterinary clinics as representative of cases of suspected lack of effectiveness for a heartworm preventive, and for which an owner satisfaction claim had been filed with the manufacturer. Medical record data were entered into a software program, and a graphic representation was created to facilitate analysis of whether pet owners had purchased sufficient heartworm preventive for the dog to be compliant during the period when infection with Dirofilaria immitis could have led to the positive heartworm antigen test result for that patient ("window of infection"). In 243 (80.7%) cases, there was insufficient heartworm preventive purchased, leading to a gap in protection during the "window of infection". In only five cases (1.7%) there were no purchase lapses or extenuating circumstances (underdosing of medication, multiple purchase gaps outside the established window of infection, or dogs have been diagnosed with heartworm infection more than once during the period studied). Half the cases were from multiple-dog households, and in many of these households, sharing of product between pets was acknowledged. In another 28% of the cases from multiple-dog households, more product was purchased than was needed for one dog, suggesting that the product was being shared between more than one pet. In most cases, there was at least one reason that a dog did not receive sufficient heartworm preventive product, placing the dog at risk of developing an infection with mature heartworms. Several actions were identified that veterinary clinics can take to improve heartworm disease prevention in their patients.
authors.affiliation: Department of Clinical Sciences, North Carolina State University, 1052 William Moore Drive, Raleigh, NC 27607, United States. Electronic address: clarke_atkins@ncsu.edu.
authors.forename: Clarke E
authors.initials: CE
authors.lastname: Atkins
authors.affiliation: Merial Limited, 3239 Satellite Blvd., Duluth, GA 30096, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Murray
authors.affiliation: Merial Limited, 3239 Satellite Blvd., Duluth, GA 30096, United States.
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: Olavessen
authors.affiliation: Merial Limited, 3239 Satellite Blvd., Duluth, GA 30096, United States.
authors.forename: K Wade
authors.initials: KW
authors.lastname: Burton
authors.affiliation: Merial Limited, 3239 Satellite Blvd., Duluth, GA 30096, United States.
authors.forename: James W
authors.initials: JW
authors.lastname: Marshall
authors.affiliation: Merial Limited, 3239 Satellite Blvd., Duluth, GA 30096, United States.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Brooks
mesh_terms: D000818:Animals; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000517:prevention & control*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D001330:Electronic Data Processing; D005369:Filaricides / Q000008:administration & dosage*; D012189:Retrospective Studies; D015144:Southeastern United States; D013714:Tennessee; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D005369:Filaricides
keywords: Dirofilaria immitis; Efficacy; Heartworm preventive; Macrocyclic lactone