title: Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis.
abstract: Aciclovir is an anti-viral frequently used for herpes virus infections. Neurotoxicity and nephrotoxicity are uncommon but serious side effects of aciclovir treatment. This case illustrates how aciclovir induced neurotoxicity can present and how it can be diagnosed using quantitative assays of aciclovir and its metabolite in the CSF and serum.
authors.affiliation: Department of Infectious Diseases, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom(1). Electronic address: Louise.berry@nuh.nhs.uk.
authors.forename: L
authors.initials: L
authors.lastname: Berry
authors.affiliation: Department of Infectious Diseases, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom(1).
authors.forename: P
authors.initials: P
authors.lastname: Venkatesan
mesh_terms: D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000737:chemistry; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis*; D044967:Serum / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D006147:Guanine; C035400:9-carboxymethoxymethylguanine; D000212:Acyclovir
keywords: 9-Carboxymethoxymethylguanine; ACV; Aciclovir; CMMG; Neurotoxicity