title: Pharmaceutical properties of a low-substituted hydroxypropyl cellulose (L-HPC) hydrogel as a novel external dressing.
abstract: Controlling the moisture balance between exudates and their transpiration from the surface of wounded skin is important for healing. Low-substituted hydroxypropyl cellulose (L-HPC) hydrogel sheets (HGSs) possessing high water retention and water vapor transmission properties were prepared by neutralizing the highly viscous alkaline liquid of 7-10% L-HPC. Glycerol-impregnated L-HPC hydrogel sheets (L-HPC G-HGSs) were obtained by exchanging aqueous liquid in L-HPC HGSs. The physical characteristics required for wound dressings, i.e., mechanical strength, adhesive strength, and water retention properties, as well as the water vapor transmission (WVT) properties of L-HPC HGSs and L-HPC G-HGSs were evaluated. The mechanical strengths of L-HPC HGSs were enhanced with increases in the L-HPC content. The impregnation of glycerol in L-HPC HGSs yielded a significantly elasticated sheet. The adhesive strengths of L-HPC HGSs were significantly lower than those of commercial medical dressings. Water retention in L-HPC HGSs after being stored for 2h at 37°C was approximately 50%. The WVT rate of 7% L-HPC HGS was approximately 40g/m(2)/h, which was markedly higher than that of silicone gel type medical dressings. In conclusion, L-HPC HGSs are promising dressings that maintain an adequate moisture balance by transpiring excessive wound exudates with less damage to the healing wound.
authors.affiliation: Department of Pharmaceutical Formulation Design, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ogawa
authors.affiliation: Department of Pharmaceutical Formulation Design, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Nakayama
authors.affiliation: Department of Pharmaceutical Formulation Design, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Uehara
authors.affiliation: Department of Pharmaceutical Formulation Design, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Clinical Pharmacokinetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Aiba
authors.affiliation: Department of Pharmaceutical Formulation Design, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. Electronic address: kurosaki@pharm.okayama-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kurosaki
mesh_terms: D000268:Adhesiveness; D000818:Animals; D047070:Bandages, Hydrocolloid; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D013314:Stress, Mechanical; D013718:Tensile Strength; D014835:Volatilization; D014867:Water / Q000032:analysis; D014945:Wound Healing / Q000187:drug effects
chemical_list: D014867:Water; D002482:Cellulose; C008079:hydroxypropylcellulose
keywords: Adhesive strength; Dressing; Hydrogel; Low-substituted hydroxypropyl cellulose (L-HPC); Water retention; Water vapor transmission