title: Five new eudesmane-type sesquiterpenoids from Chinese agarwood induced by artificial holing.
abstract: Five new eudesmane-type sesquiterpenoids (1-5), along with six known ones (6-11), were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae). The structures of the new sesquiterpenoids were established by spectroscopic methods including UV, IR, MS, 1D, and 2D NMR. Compounds 1, 3, 6 and 7 exhibited antibacterial activities against both Staphylococcus aureus and Ralstonia solanacearum, and compound 5 only showed an inhibitory activity towards S. aureus. Compounds 1, 6, 7 and 10 showed weak acetylcholinesterase inhibitory activity.
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Cai-Hong
authors.initials: CH
authors.lastname: Cai
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zuo
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: meiwenli@itbb.org.cn.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D043367:Ralstonia / Q000187:drug effects; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane
keywords: AChE inhibitory activities; Agarwood induced by artificial holing; Antibacterial activities; Aquilaria sinensis (Lour.) Gilg; Sesquiterpenoids; Thymelaeaceae