title: Chronic gastritis - an update.
abstract: Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Mariya
authors.initials: M
authors.lastname: Varbanova
authors.affiliation: Institute of Pathology, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Frauenschläger
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: peter.malfertheiner@med.ovgu.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000752:Anemia, Pernicious / Q000175:diagnosis; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases; D002908:Chronic Disease; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D010295:Parietal Cells, Gastric / Q000276:immunology; D014806:Vitamin B 12 Deficiency / Q000175:diagnosis
chemical_list: D001323:Autoantibodies; D001324:Autoantigens
keywords: Autoimmune gastritis; Gastritis; Helicobacter pylori; Pernicious anaemia