title: Inhibition of α-glucosidase by polysaccharides from the fruit hull of Camellia oleifera Abel.
abstract: We isolated and purified polysaccharides from the Camellia oleifera Abel. fruit hull and studied its hypoglycemic potential. Our results revealed six polysaccharides (CFPA-1-5 & CFPB) from the aqueous extract from the defatted C. oleifera fruit hull. Purified polysaccharides (purity >90%) were investigated for the inhibition of α-glucosidase activity in vitro. Two polysaccharides, CFPB and CFPA-3 were present in high concentration in the fruit hull and showed a dose-dependent inhibition of α-glucosidase activity, with IC50 concentrations of 11.80 and 10.95 μg/mL, respectively. This result suggests that polysaccharides (CFP) extracted from the fruit hull of C. oleifera may have potential as functional foods with featuring a hypoglycemic effect.
authors.affiliation: College of Materials and Engineering, Central South University of Forestry and Technology, Changsha 410004, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Materials and Engineering, Central South University of Forestry and Technology, Changsha 410004, PR China. Electronic address: gingshen123@126.com.
authors.forename: Xiang-Zhou
authors.initials: XZ
authors.lastname: Li
mesh_terms: D028244:Camellia / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D011134:Polysaccharides; D000520:alpha-Glucosidases
keywords: Camellia oleifera Abel fruit hull; Polysaccharides; α-Glucosidase inhibition