title: Intercellular adhesion molecule 1 and progression of percent emphysema: the MESA Lung Study.
abstract: BACKGROUND
  Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline.
  
  
  METHODS
  The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors.
  
  
  RESULTS
  Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function.
  
  
  CONCLUSIONS
  Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Carrie P
authors.initials: CP
authors.lastname: Aaron
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Schwartz
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
authors.affiliation: Department of Radiology, University of Iowa, Iowa City, IA, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
authors.affiliation: Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: John H M
authors.initials: JH
authors.lastname: Austin
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Oelsner
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Donohue
authors.affiliation: Department of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Kalhan
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Berardi
authors.affiliation: Department of Environmental Medicine and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Kaufman
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.affiliation: Department of Pathology, University of Vermont, Colchester, VT, USA.
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: rgb9@columbia.edu.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
mesh_terms: D000368:Aged; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging*; D013147:Spirometry; D014057:Tomography, X-Ray Computed / Q000379:methods; D014797:Vital Capacity / Q000502:physiology
chemical_list: D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1
keywords: CT imaging; Emphysema; Endothelium; Intercellular adhesion molecule-1