title: Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.
abstract: Regenerative medicine has entered a rapid phase of discovery, and much has been learned in recent years about the lung's response to injury. This article first summarizes the cellular and molecular mechanisms that damage the alveolar-capillary barrier, producing acute respiratory distress syndrome (ARDS). The latest understanding of endogenous repair processes is discussed, highlighting the diversity of lung epithelial progenitor cell populations and their regulation in health and disease. Finally, the past, present, and future of exogenous cell-based therapies for ARDS is reviewed.
authors.affiliation: Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0624, USA.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Gotts
authors.affiliation: Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0624, USA. Electronic address: Michael.matthay@ucsf.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Matthay
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000628:therapy*
keywords: Acute respiratory distress syndrome; Lung progenitor cells; Mesenchymal stem/stromal cells