title: Combination of androgen deprivation therapy and radiotherapy for localized prostate cancer in the contemporary era.
abstract: Currently, androgen deprivation therapy (ADT) has a well-defined role when administered together with radiotherapy (RT): neo-adjuvant and concurrent combination for intermediate risk-disease and adjuvant therapy for high risk disease. Evidence of this association was generated by randomized trials designed and led approximately 30 years ago; thus the question which arises is how relevant and portable are these data in our current clinical practice? In the present review, we examine the pitfalls of these published randomized controlled trials, their relevance to present daily clinics, where high-dose external beam RT or brachytherapy is applied, as well as the adoption of ADT in patients with concomitant cardiovascular disorders.
authors.affiliation: Radiation Oncology Campus Bio-Medico University, Rome Italy. Electronic address: r.dangelillo@unicampus.it.
authors.forename: Rolando M
authors.initials: RM
authors.lastname: D'Angelillo
authors.affiliation: Department of Oncology, Radiation Oncology, University of Turin School of Medicine, Turin, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne Switzerland.
authors.forename: Berardino
authors.initials: B
authors.lastname: De Bari
authors.affiliation: Radiation Oncology Department, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.
authors.forename: Alba
authors.initials: A
authors.lastname: Fiorentino
authors.affiliation: Radiation Oncology, Azienda Ospedaliera S. Camillo-Forlanini, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Arcangeli
authors.affiliation: Radiation Oncology Department, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Alongi
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods*; D015870:Gene Expression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D011944:Receptors, Androgen / Q000235:genetics*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D011944:Receptors, Androgen
keywords: Androgen deprivation therapy; Brachytherapy.; Prostate cancer; Radiotherapy