title: Steroidal saponins with induced platelet aggregation activity  from the aerial parts of Paris verticillata.
abstract: In order to utilize and protect the resources of Rhizoma Paridis rationally, we carried out a phytochemical investigation on the non-medicinal (aerial) parts of Paris verticillata that led to the isolation of fifteen steroidal saponins. Among them, three are new spirostanol saponins, named parisverticosides A–C (1–3), as well as one new cholestane glycoside, named parisverticoside D (4). Their structures were elucidated by extensive spectroscopic analysis and acid hydrolysis. The aglycone of compound 1 is a new spirostane and identified as (23S,24S,25S)-spirost-5-en-1b,3b,23, 24-tetraol. The selected isolates were evaluated for induced platelet aggregation activity and compound 5 showed 62% maximal platelet aggregation rate at the concentration of 300 lg/mL.
authors.forename: Chang-Li
authors.initials: CL
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Ni
authors.forename: Huan
authors.initials: H
authors.lastname: Yan
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Lian
authors.initials: L
authors.lastname: Yang
authors.forename: Yong-Ai
authors.initials: YA
authors.lastname: Si
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
authors.forename: Chang-Xiang
authors.initials: CX
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Zhao
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
mesh_terms: D019668:Liliaceae / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000494:pharmacology
chemical_list: D012503:Saponins; D013150:Spirostans