title: Male sexual dysfunction and ankylosing spondylitis: a systematic review and metaanalysis.
abstract: OBJECTIVE
  No consensus has been reached on sexual dysfunction in men with ankylosing spondylitis (AS). Our study aimed to derive a more precise estimation of the sexual function and its clinical correlations in men with AS.
  
  
  METHODS
  A metaanalysis was performed and the related literature were searched in PubMed, Elsevier Science Direct, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and in reference lists of articles and systematic reviews. Score of the International Index of Erectile Function (IIEF) was used as the outcome measurement, and standardized mean differences (SMD) with 95% CI were calculated.
  
  
  RESULTS
  Eleven studies were included, including 535 men with AS and 430 male controls. Each domain of the IIEF score (erectile function: SMD -0.52, 95% CI -0.68 - -0.37; orgasmic function: -0.72, -1.03 - -0.42; sexual drive: -0.40, -0.62 - -0.18; intercourse satisfaction: -0.86, -1.15 - -0.56; and overall satisfaction: -0.61, -0.91 - -0.32) were lower in men with AS than in controls. In the subgroup analysis, the results did not change except for the sexual drive in the Asians group (-0.15, -0.42-0.13). At metaregression, no study characteristics were significantly associated with effect size of the IIEF score.
  
  
  CONCLUSIONS
  Sexual function is impaired in male patients with AS and further studies are necessary to better understand risk factors for sexual dysfunction in this population.
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Fan
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Si
authors.initials: S
authors.lastname: Liu
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Hu
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Guoqi
authors.initials: G
authors.lastname: Cai
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Guo
authors.initials: G
authors.lastname: Xia
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Lihong
authors.initials: L
authors.lastname: Xin
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Shengqian
authors.initials: S
authors.lastname: Xu
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zou
authors.affiliation: From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and the Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, China.D. Fan, MD; L. Liu, MD; N. Ding, MD; S. Liu, MD; Y. Hu, MD; G. Cai, MD; G. Xia, MD; L. Xin, MD; L. Wang, MD; Y. Zou, PhD; F. Pan, PhD, Department of Epidemiology and Biostatistics, School of Public Health; S. Xu, PhD; J. Xu, PhD, Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University. famingpan@ahmu.edu.cn.
authors.forename: Faming
authors.initials: F
authors.lastname: Pan
mesh_terms: D006801:Humans; D007989:Libido / Q000502:physiology*; D008297:Male; D010549:Personal Satisfaction; D012735:Sexual Dysfunction, Physiological / Q000150:complications*; D013167:Spondylitis, Ankylosing / Q000150:complications*
keywords: ANKYLOSING SPONDYLITIS; MEN; METAANALYSIS; SEXUAL DYSFUNCTION