title: The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia-reperfusion.
abstract: Many literatures have proven that postoperative cognitive dysfunction (POCD) was very common in old patients after the injury of acute myocardial ischemia-reperfusion (AMIR) clinically such as the off-pump coronary artery bypass surgery (OPCAB) without definite mechanism; however, reports on the animal experiments were rarely seen. We hypothesized that AMIR could contribute to cognitive dysfunction, and this severe injury might be impeded by EA via hindering neuroinflammation and oxidative stress response as well as modulating the balance of the autonomic nervous system. The aged male Sprague Dawley rats were randomly assigned into three experimental groups: sham (sham operation), AMIR, and EA (electroacupunture treatment, acupoints GV20 and ST36+AMIR) groups. The survival rate, heart rate variability analysis, examination of pathology within the hippocampal CA1, oxidative stress, systemic inflammation and the behavior testing were evaluated by their corresponding methods. The results showed that the rats subjected to AMIR had lower survival rates, higher malondialdehyde (MDA), decreased superoxide dismutase (SOD) activity, more microglial activation, and presented evidence of severe brain injury and cognitive dysfunction on the 1st, 3rd, 7th days after reperfusion compared to sham-operated controls. Most important of all, the above damages induced by the AMIR were significantly improved by the EA treatment. Our findings indicated that EA treatment could be a neuroprotective therapy for the cognitive dysfunction induced by the AMIR event, which might be attributablefor balancing the autonomic nervous system, inhibiting the neuronic apoptosis, hindering microglial activation, attenuating oxidative stress and restraining the central and peripheral inflammation reactions.
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China. Electronic address: 15244609310@163.com.
authors.forename: Shaoting
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China.
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Bo
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China. Electronic address: wenzhili9@126.com.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine,Harbin 150081, China.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D056547:CA1 Region, Hippocampal / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D006339:Heart Rate; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017628:Microglia / Q000473:pathology / Q000502:physiology; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Acute myocardial ischemia–reperfusion (AMIR); Electroacupunture; Off-pump coronary artery bypass surgery (OPCAB); Postoperative cognitive dysfunction (POCD)