title: Tabebuia aurea decreases inflammatory, myotoxic and hemorrhagic activities induced by the venom of Bothrops neuwiedi.
abstract: BACKGROUND
  Ethnobotanical studies show that Tabebuia aurea has been used as anti-inflammatory and for snake bite. Evaluate the effect of treatment with the hydroethanolic extract of Tabebuia aurea (HETa) on inflammatory, hemorrhagic and myotoxic activities induced by Bothrops neuwiedi (BnV) in mice.
  
  
  METHODS
  The anti-inflammatory, antihemorragic and antimyotoxic properties of the HETa 100, 200 and 400mg/kg or BnV neutralized with HETa (1:50) were evaluated using the following animal models: BnV-induced paw edema, BnV-induced recruitment of polymorphonuclear cells into the peritoneal cavity, hemorrhagic activity, myotoxic activity and hydrogen peroxide production by peritoneal macrophages in vitro.
  
  
  RESULTS
  HETa inhibited the paw edema and polymorphonuclear cell recruitment into the peritoneal cavity. BnV neutralized with HETa reduced the hemorrhagic activity and histopathological analysis of skeletal muscle tissue showed that the hemorrhagic area was smaller and multifocal. The leukocyte infiltrate was less intense and muscle necrosis discrete. BnV induced hydrogen peroxide production and BnV neutralized reduced this production. In addition, the HETa was nontoxic to macrophages.
  
  
  CONCLUSIONS
  The activities of the HETa presented herein justify the popular use of Tabebuia aurea in inflammatory situations from snake bite.
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Fernanda Paes
authors.initials: FP
authors.lastname: Reis
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Iluska Moslaves
authors.initials: IM
authors.lastname: Senna Bonfa
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Rafael Bezerra
authors.initials: RB
authors.lastname: Cavalcante
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Denis
authors.initials: D
authors.lastname: Okoba
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Simone Bertozi
authors.initials: SB
authors.lastname: de Souza Vasconcelos
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Luciane
authors.initials: L
authors.lastname: Candeloro
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Wander Fernando
authors.initials: WF
authors.lastname: de Oliveira Filiu
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Duenhas Monreal
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Valter Jose
authors.initials: VJ
authors.lastname: da Silva
authors.affiliation: Biotério Central, Universidade Católica Dom Bosco, 79117-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Paula Helena
authors.initials: PH
authors.lastname: Santa Rita
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Carlos Alexandre
authors.initials: CA
authors.lastname: Carollo
authors.affiliation: Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brazil. Electronic address: monica.kadri@ufms.br.
authors.forename: Mônica Cristina
authors.initials: MC
authors.lastname: Toffoli-Kadri
mesh_terms: D000818:Animals; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009132:Muscles / Q000187:drug effects* / Q000473:pathology; D010936:Plant Extracts / Q000627:therapeutic use*; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D003435:Crotalid Venoms; D010936:Plant Extracts; D006861:Hydrogen Peroxide
keywords: Anti-inflammatory; Antihemorragic; Antimyotoxic; Bothrops; Paratudo; Snake bite