title: [Effects-of combined calories restriction and polyunsaturated fatty acids on colitis in rats].
abstract: OBJECTIVE
  To explore the effect of n-6 and n-3 polyunsaturated fatty acids combined with calorie restriction( CR) in DSS induced ulcerative colitis rats.
  
  
  METHODS
  Forty female rats were randomly divided into five groups, control group, model group, CR group, 5:1 PUFA ad libitum group, 5: 1 PUFA CR group. CR groups provided with a limited daily food allotment of 60% of that eaten by the ad libitum animals for 14 weeks. Ulcerative colitis model in rats were given 5. 0% dextran sulfate sodium in their drinking water for 7 days.
  
  
  RESULTS
  5:1 PUFA CR group significantly decreased body weight, disease activity index, macroscopic and histological score compared to model group. In addition, administration of 5: 1 PUFA CR effectively inhibited MPO activity. The levels of TNF-α and IL-6 in the serum with colitis were decreased by 5: 1 PUFA CR (P <0. 05).
  
  
  CONCLUSIONS
  These results suggest that combination of calories restriction and n-6/n-3 =5:1 PUFA may be more beneficial in attenuating the progression of DSS induced ulcerative colitis.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qian
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Li
authors.forename: Fubin
authors.initials: F
authors.lastname: Qiu
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000178:diet therapy*; D016264:Dextran Sulfate / Q000633:toxicity*; D004041:Dietary Fats / Q000008:administration & dosage; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016264:Dextran Sulfate