title: Transplantation in acute myeloid leukemia.
abstract: Acute myeloid leukemia (AML) is associated with poor outcome mainly because of relapse. The best antileukemic treatment is allogeneic stem cell transplantation. However, the associated significant nonrelapse mortality limits both the application and outcome of the procedure. Recent advances in understanding the genetic landscape of the disease enable educated selection of patients. Improved treatment protocols, supportive therapy, patient selection, and posttransplant manipulations all contribute to a better outcome.
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8 Haalia Hshnia Street, Bat Galim, Haifa 3525408, Israel; The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Efron Street, P.O.B. 9649, Bat Galim, Haifa 31096, Israel. Electronic address: t_zuckerman@rambam.health.gov.il.
authors.forename: Tsila
authors.initials: T
authors.lastname: Zuckerman
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8 Haalia Hshnia Street, Bat Galim, Haifa 3525408, Israel; The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Efron Street, P.O.B. 9649, Bat Galim, Haifa 31096, Israel; Department of Hematology, Shaare Zedek Medical Center, 12 Shmuel Bait Street, Jerusalem 9102102, Israel.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Rowe
mesh_terms: D000208:Acute Disease; D014408:Biomarkers, Tumor / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis; D016019:Survival Analysis; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Acute myeloid leukemia; Allogeneic stem cell transplantation; Autologous stem cell transplantation; Complete remission; Genetic alterations