title: Extra-nodal B-cell non-Hodgkin's lymphomas of the head and neck: a study of 68 cases.
abstract: OBJECTIVE
  The objectives of this study are to describe the distinctive characteristics of extra-nodal B-cell non-Hodgkin's lymphomas (BNHLs) located in the head and neck in a series of patients, to discuss patient survival, and to compare the oral versus the non-oral locations of the extra-nodal BNHLs of the head and neck.
  
  
  METHODS
  We studied 68 patients with BNHL of the head and neck. We analyzed the clinical and survival characteristics. Additionally, we performed Kaplan-Meier and Cox regression analyses to determine the influence of the different factors on survival.
  
  
  RESULTS
  This study included 68 non-nodal lymphomas; 30 lymphomas (31.9%) were located intraorally, with the gingiva as the most frequent location. The oral lymphomas in stages 1 and 2 showed a prevalence of 60% (18/30). The Kaplan-Meier analysis showed that the stage of disease and the oral versus non-oral extranodal lymphomas were significant prognostic factors (p<0.05). However, the multivariate Cox analysis indicated that only complete remission and oral versus non-oral location were significant prognostic factors (p<0.01).
  
  
  CONCLUSIONS
  The gingiva was the most common location of the intraoral lymphomas. Complete remission and non-oral location were the only significant survival factors in the multivariate Cox regression analysis.
authors.affiliation: Department of Oral Medicine, Valencia University, Valencia, Spain; Department of Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain. Electronic address: bagan@uv.es.
authors.forename: Jose V
authors.initials: JV
authors.lastname: Bagan
authors.affiliation: Department of Hematology, Valencia University, Valencia, Spain; Department of Hematology, University General Hospital, Valencia, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Carbonell
authors.affiliation: ENT Unit, University General Hospital, Valencia, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Gómez
authors.affiliation: Department of Hematology, University General Hospital, Valencia, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sánchez
authors.affiliation: Department of Pathology, University General Hospital, Valencia, Spain.
authors.forename: Atilio
authors.initials: A
authors.lastname: Navarro
authors.affiliation: Department of Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Leopoldo
authors.affiliation: Department of Oral Medicine, Valencia University, Valencia, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Bagán
authors.affiliation: ENT Unit, University General Hospital, Valencia, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Zapater
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate