title: A C. elegans homolog of the Cockayne syndrome complementation group A gene.
abstract: Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA and CSB. The links between the molecular functions of the CS genes and the complex pathophysiology of CS are as of yet poorly understood and are the subject of intense debate. While mouse models reflect the complexity of CS, studies on simpler genetic models might shed new light on the consequences of CS mutations. Here we describe a functional homolog of the human CSA gene in Caenorhabditis elegans. Similar to its human counterpart, mutations in the nematode csa-1 gene lead to developmental growth defects as a consequence of DNA lesions.
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
authors.forename: Vipin
authors.initials: V
authors.lastname: Babu
authors.affiliation: Institute for Genetics, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.
authors.forename: Kay
authors.initials: K
authors.lastname: Hofmann
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
authors.forename: Björn
authors.initials: B
authors.lastname: Schumacher
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000528:radiation effects; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects; D045643:DNA Repair Enzymes / Q000235:genetics* / Q000378:metabolism; D005260:Female; D009154:Mutation; D000081223:Polycyclic Sesquiterpenes; D017386:Sequence Homology, Amino Acid; D012717:Sesquiterpenes; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D029742:Caenorhabditis elegans Proteins; C095472:ERCC8 protein, human; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D014157:Transcription Factors; C052673:illudin M; D045643:DNA Repair Enzymes
keywords: C. elegans; Cockayne syndrome; Nucleotide excision repair