title: Antioxidant capacity of synovial fluid in the temporomandibular joint correlated with radiological morphology of temporomandibular disorders.
abstract: We investigated the correlation between the antioxidant capacity of synovial fluid and radiological findings of intra-articular structures in patients with disorders of the temporomandibular joint (TMJ). We recruited 21 patients (9 men and 12 women, aged 18-84 years of age) with such disorders, excluding myofascial pain and dysfunction syndrome, or other muscular disorders. The clinical variables recorded included age, sex, interincisal distance, and visual analogue pain scores (VAS). Radiological findings were obtained from diagnostic arthrogram and cone-beam computed tomography (CT). The antioxidant capacity of the synovial fluid was measured by chemiluminescence. Eleven patients were radiologically diagnosed with closed lock, and the remaining 10 with no closed lock. An anchored intra-articular disc was most often seen on cone-beam CT (n=19) followed by perforated disc (n=7), osteoarthrosis (n=7), and anterior disc displacement without reduction (n=5). Although there were no significant differences between antioxidant capacity and age, sex, VAS, or any findings on cone-beam CT, antioxidant capacity was significantly decreased in the patients with closed lock compared with those who did not have closed lock (p=0.02). The results suggest an association between the oxidative stress of the synovial fluid and closed-lock in disorders of the TMJ.
authors.affiliation: Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ishimaru
authors.affiliation: Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Seigo
authors.initials: S
authors.lastname: Ohba
authors.affiliation: Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshimura
authors.affiliation: Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Matsuda
authors.affiliation: Department of Oral and Maxillofacial Surgery, Gifu Prefectural General Medical Centre, Gifu, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Ishimaru
authors.affiliation: Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: sano@u-fukui.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sano
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis*; D001175:Arthrography / Q000379:methods; D054893:Cone-Beam Computed Tomography / Q000379:methods; D003287:Contrast Media; D003974:Diatrizoate Meglumine; D005260:Female; D006801:Humans; D004204:Joint Dislocations / Q000000981:diagnostic imaging / Q000378:metabolism; D049449:Luminescence; D008297:Male; D008335:Mandibular Condyle / Q000000981:diagnostic imaging / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010147:Pain Measurement / Q000379:methods; D016059:Range of Motion, Articular / Q000502:physiology; D012737:Sex Factors; D013582:Synovial Fluid / Q000737:chemistry* / Q000000981:diagnostic imaging; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging / Q000378:metabolism*; D019224:Temporomandibular Joint Disc / Q000000981:diagnostic imaging / Q000378:metabolism; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D003287:Contrast Media; D003974:Diatrizoate Meglumine
keywords: Antioxidant capacity; Hydroxyl radical; Oxidative stress; Radiological morphology; Synovial fluid; Temporomandibular disorders