title: Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration.
abstract: OBJECTIVE
  To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves (BPE) against different gastric ulcer models in rats.
  
  
  METHODS
  The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress (CRS), and pylorus ligation (PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model.
  
  
  RESULTS
  BPE showed a dose-dependent ulcer protective effect in PL (18.67%-66.26% protection), aspirin (24.65%-63.25% protection), CRS (20.77%-59.42% protection), and EtOH (16.93%-77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO (P < 0.01-0.001), SOD (P < 0.01-0.001), and an increase in CAT (P < 0.01-0.001), activity in the CRS-induced model.
  
  
  CONCLUSIONS
  The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.
authors.affiliation: Department of Pharmacy, Rameshwaram Institutes of Technology & Management, Lucknow 226020, Uttar Pradesh, India.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Jaiswal
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Dubey
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Das
authors.affiliation: Pharmacognosy & Ethnopharmacology Div., National Botanical Research Institute (CSIR), Rana Pratap Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address: sunil_pharmachem90@yahoo.co.in.
authors.forename: Ch V
authors.initials: ChV
authors.lastname: Rao
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006801:Humans; D039823:Iridoids / Q000008:administration & dosage*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D039823:Iridoids; D010936:Plant Extracts; D020011:Protective Agents
keywords: Anti-ulcer activity; Antioxidant enzymes; Barleria prionitis; HPTLC; Iridoid