title: [Frequency of lymphoscintigraphic anomalies in the contralateral limb and progression of unilateral primary lymphedema in children].
abstract: BACKGROUND
  Primary lymphoedema (LE) is the consequence of lymphatic insufficiency, usually associated with hypoplasia of the lymph vessels and/or nodes. Lymphoscintigraphy allows early diagnosis.
  
  
  OBJECTIVE
  To assess the frequency of contralateral LE by lymphoscintigraphy in children with unilateral primary LE of one limb; to assess facets of clinical bilateralization of LE.
  
  
  METHODS
  This retrospective single-centre study included children with unilateral LE followed up at the Tours university hospital centre between 2004 and 2014. Parents were contacted by phone to obtain follow-up data.
  
  
  RESULTS
  Of the 13 children included, 6 (46%) displayed bilateral lymphatic anomalies on lymphoscintigraphy. Within a median follow-up period of 6 years, clinical bilateralization was observed in one girl after progression of her LE for 7 years; in her case, bilateral lymphatic insufficiency was detected at the initial lymphoscintigraphy.
  
  
  CONCLUSIONS
  While contralateral subclinical lymphatic insufficiency is frequent in children with unilateral primary LE of the limbs, clinical bilateralization appears only rarely.
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de pédiatrie, CHRU de Tours, 37044 Tours cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Blein
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de médecine nucléaire, CHRU de Tours, 37044 Tours cedex 9, France.
authors.forename: F
authors.initials: F
authors.lastname: Baulieu
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de dermatologie, CHRU de Tours, 37044 Tours cedex 9, France; Inserm U930, 37044 Tours cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Vaillant
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de dermatologie, CHRU de Tours, 37044 Tours cedex 9, France; ISP 1282, UMR INRA, 37044 Tours cedex 9, France.
authors.forename: G
authors.initials: G
authors.lastname: Lorette
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de dermatologie, CHRU de Tours, 37044 Tours cedex 9, France; ISP 1282, UMR INRA, 37044 Tours cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Samimi
authors.affiliation: Université François-Rabelais de Tours, CHRU de Tours, 37044 Tours cedex 9, France; Service de dermatologie, CHRU de Tours, 37044 Tours cedex 9, France; Inserm U930, 37044 Tours cedex 9, France. Electronic address: annabel.maruani@univ-tours.fr.
authors.forename: A
authors.initials: A
authors.lastname: Maruani
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D057210:Delayed Diagnosis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D035002:Lower Extremity / Q000000981:diagnostic imaging; D008200:Lymphangiectasis / Q000000981:diagnostic imaging; D042601:Lymphatic Vessels / Q000002:abnormalities / Q000000981:diagnostic imaging; D008209:Lymphedema / Q000000981:diagnostic imaging*; D061305:Lymphoscintigraphy / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D034941:Upper Extremity / Q000000981:diagnostic imaging
keywords: Child; Enfant; Ganglion; Hypoplasia; Hypoplasie; Lymph node; Lymphedema; Lymphologie; Lymphology; Lymphoscintigraphie; Lymphoscintigraphy; Lymphœdème