title: A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory.
abstract: Novel dual vaccine, WSN-Aβ(1-10), based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ(1-10) enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ(1-10) within the context of an inactivated influenza virus vaccine. These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
authors.forename: Hayk
authors.initials: H
authors.lastname: Davtyan
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
authors.forename: Anahit
authors.initials: A
authors.lastname: Ghochikyan
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
authors.forename: Armine
authors.initials: A
authors.lastname: Hovakimyan
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
authors.forename: Arpine
authors.initials: A
authors.lastname: Davtyan
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Cadagan
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Marleau
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Randy A
authors.initials: RA
authors.lastname: Albrecht
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA; Department of Medicine, Division of Infection Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Adolfo
authors.initials: A
authors.lastname: García-Sastre
authors.affiliation: Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA; University of California, Irvine, Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697, USA. Electronic address: magadjanyan@immed.org.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Agadjanyan
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D023582:Alzheimer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D016229:Amyloid beta-Peptides / Q000276:immunology* / Q000633:toxicity; D000704:Analysis of Variance; D000818:Animals; D000906:Antibodies / Q000097:blood; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory
chemical_list: D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D000906:Antibodies
keywords: Alzheimer's disease; Dual vaccine; Immune responses; Influenza; Memory T cells