title: Plasmodium and mononuclear phagocytes.
abstract: Plasmodium, the causative agent of malaria, initially multiplies inside liver cells and then in successive cycles inside erythrocytes, causing the symptoms of the disease. In this review, we discuss interactions between the extracellular and intracellular forms of the Plasmodium parasite and innate immune cells in the mammalian host, with a special emphasis on mononuclear phagocytes. We overview here what is known about the innate immune cells that interact with parasites, mechanisms used by the parasite to evade them, and the protective or detrimental contribution of these interactions on parasite progression through its life cycle and pathology in the host.
authors.affiliation: Malaria Biology and Genetics Unit, Department of Parasitology, Pasteur Institute, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Mac-Daniel
authors.affiliation: Malaria Biology and Genetics Unit, Department of Parasitology, Pasteur Institute, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address: robert.menard@pasteur.fr.
authors.forename: Robert
authors.initials: R
authors.lastname: Ménard
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D010586:Phagocytes / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology / Q000502:physiology*
keywords: Innate immunity; Mononuclear phagocytes; Plasmodium