title: HORMA domains at the heart of meiotic chromosome dynamics.
abstract: HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.
authors.affiliation: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. Electronic address: gerben.vader@mpi-dortmund.mpg.de.
authors.forename: Gerben
authors.initials: G
authors.lastname: Vader
authors.affiliation: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, 45117 Essen, Germany. Electronic address: andrea.musacchio@mpi-dortmund.mpg.de.
authors.forename: Andrea
authors.initials: A
authors.lastname: Musacchio
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D023902:Chromosome Pairing / Q000235:genetics*; D002875:Chromosomes / Q000378:metabolism*; D008540:Meiosis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013573:Synaptonemal Complex / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins