title: Risk assessment derived from migrants identified in several adhesives commonly used in food contact materials.
abstract: Adhesives are used to manufacture multilayer materials, where their components pass through the layers and migrate to the food. Nine different adhesives (acrylic, vinyl and hotmelt) and their migration in 21 laminates for future use as market samples have been evaluated and risk assessment has been carried out. A total of 75 volatiles and non volatile compounds were identified by gas chromatography-mass spectrometry and ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Most of the compounds migrated below their specific migration limit (SML), lowest observed adverse effect level (LOAEL), no observed adverse effect level (NOAEL) and values recommended by Cramer. Six compounds classified as high toxicity class III according to Cramer classification, migrated over their SML and exposure values recommended by Cramer, when they were applied in the full area of the packaging. Nevertheless, these adhesives fulfill the threshold in the real application as they are applied in a small area of the packaging.
authors.affiliation: GUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna,3, 50018 Zaragoza, Spain; Samtack Adhesivos Industriales, C/ Cerámica, n°3, Pol. Ind. Magarola Sud, 08292, Esparreguera, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Canellas
authors.affiliation: GUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna,3, 50018 Zaragoza, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Vera
authors.affiliation: GUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna,3, 50018 Zaragoza, Spain. Electronic address: cnerin@unizar.es.
authors.forename: C
authors.initials: C
authors.lastname: Nerín
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging / Q000592:standards*; D008401:Gas Chromatography-Mass Spectrometry; D019055:No-Observed-Adverse-Effect Level; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D000269:Adhesives; D055549:Volatile Organic Compounds
keywords: Adhesives; Food contact materials; GC-MS; Migration; UPLC-MS/QTOF