title: Canine hereditary ataxia.
abstract: The hereditary ataxias are a group of neurodegenerative diseases that cause a progressive (or episodic) cerebellar ataxia. A large number of different disorders have been described in different breeds of purebred dog, and in some instances, more than one disorder occurs in a single breed, creating a confusing clinical picture. The mutations associated with these disorders are being described at a rapid rate, potentially changing our ability to prevent, diagnose, and treat affected dogs. A breed-related neurodegenerative process should be suspected in any pure bred dog with slowly progressive, symmetric signs of ataxia.
authors.affiliation: Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, 999 Phuttamonthon Sai 4 Road, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand.
authors.forename: Ganokon
authors.initials: G
authors.lastname: Urkasemsin
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address: natasha_olby@ncsu.edu.
authors.forename: Natasha J
authors.initials: NJ
authors.lastname: Olby
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D004285:Dogs; D020022:Genetic Predisposition to Disease; D013132:Spinocerebellar Degenerations / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000628:therapy / Q000662:veterinary*
keywords: Cerebellar abiotrophy; Granuloprival degeneration; Purkinje neuron; Spinocerebellar