title: Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: development and characterization.
abstract: The aim of the current study is to explore the potential of PEG-30-dipolyhydroxystearate (Cithrol(®) DPHS) and Soluplus(®) as ingredients in novel semisolid self-nanoemulsifying drug delivery systems (SNEDDS). Semisolid SNEDDS consisting of Cithrol(®) DPHS, Capmul(®) MCM and Kolliphor(®) HS 15 were successfully prepared. The formulations were comprehensively characterized by photon correlation spectroscopy (PCS), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), electron spin resonance (ESR) and proton nuclear magnetic resonance ((1)H NMR). All formulations were semisolid at room temperature and melted at body temperature. The hydrodynamic diameter of the dispersions was less than 25 nm. The ratio Cithrol(®) DPHS:Capmul(®) MCM was found to be critical for the dispersibility and the stability of the formed nanoemulsion.
authors.affiliation: Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle (Saale), Germany.
authors.forename: Tamer H
authors.initials: TH
authors.lastname: Hassan
authors.affiliation: Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle (Saale), Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Metz
authors.affiliation: Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle (Saale), Germany. Electronic address: karsten.maeder@pharmazie.uni-halle.de.
authors.forename: Karsten
authors.initials: K
authors.lastname: Mäder
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004578:Electron Spin Resonance Spectroscopy; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D044366:Transition Temperature
chemical_list: D004655:Emulsions; D005079:Excipients; C000600434:PEG-30-dipolyhydroxystearate; D011091:Polyesters; D011145:Polyvinyls; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D011092:Polyethylene Glycols
keywords: Capmul(®) MCM; Cithrol(®) DPHS; ESR; Kolliphor(®) HS 15; PEG-30-dipolyhydroxystearate; SNEDDS; Selfemulsifying; Soluplus(®); Tempolbenzoate