title: Development of a new test for the easy characterization of the adhesion at the interface of bilayer tablets: proof-of-concept study by experimental design.
abstract: Although, adhesion at the interface of bilayer tablets is critical for their design it is difficult to characterize this adhesion between layers. In view of this, a new test with an easy implementation was proposed for the characterization of the interface of bilayer tablets. This work is presented as a proof-of-concept study to investigate the reliability of this new test with regard to the effects of some critical process parameters (e.g., compaction pressure applied on each layer) and material attributes (e.g., elasticity of the layered materials) on the interfacial adhesion of bilayer tablets. This was investigated using a design of experiment approach and the results obtained were in good accordance with those obtained with other tests and thus, confirms the potential of such a method for the measurement of the interfacial adhesion of bilayer tablets.
authors.affiliation: Univ Paris-Sud UFR de Pharmacie, 92296 Châtenay-Malabry, France; Institut de Mécanique et d'Ingénierie, I2M, UMR CNRS 5295, Bordeaux, France. Electronic address: virginie.busignies@u-psud.fr.
authors.forename: Virginie
authors.initials: V
authors.lastname: Busignies
authors.affiliation: Institut de Mécanique et d'Ingénierie, I2M, UMR CNRS 5295, Bordeaux, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Mazel
authors.affiliation: Univ Paris-Sud UFR de Pharmacie, 92296 Châtenay-Malabry, France; Institut de Mécanique et d'Ingénierie, I2M, UMR CNRS 5295, Bordeaux, France.
authors.forename: Harona
authors.initials: H
authors.lastname: Diarra
authors.affiliation: Institut de Mécanique et d'Ingénierie, I2M, UMR CNRS 5295, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Tchoreloff
mesh_terms: D000269:Adhesives; D004548:Elasticity; D005079:Excipients / Q000737:chemistry*; D054327:Lubricants / Q000737:chemistry; D010316:Particle Size; D012107:Research Design; D013314:Stress, Mechanical; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
chemical_list: D000269:Adhesives; D005079:Excipients; D054327:Lubricants; D013607:Tablets
keywords: Bilayer tablet; Delamination; Elasticity; Interfacial strength; Test device