title: The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease.
abstract: Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.
authors.affiliation: Department of Psychiatry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6G 4X8, Canada. Electronic address: schiu3207@rogers.com.
authors.forename: Simon
authors.initials: S
authors.lastname: Chiu
authors.affiliation: Department of Psychiatry, University of Puerto Rico School of Medicine, 307 Calle Eleonor Roosevelt, San Juan, PR 00918-2720, USA.
authors.forename: Michel A
authors.initials: MA
authors.lastname: Woodbury-Fariña
authors.affiliation: Oregon Health & Science University, Department Psychiatry, 3181 South West Sam Jackson Park Road, Portland, OR 97239-3098, USA.
authors.forename: Mujeeb U
authors.initials: MU
authors.lastname: Shad
authors.affiliation: Northern Ontario Medical School/Lakehead University, 955 Oliver Road, Thunder Bay, ON P7B 5E1, Canada; Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
authors.forename: Mariwan
authors.initials: M
authors.lastname: Husni
authors.affiliation: Vancouver Island Health Authority, Department of Psychiatry, Victoria, BC, University of British Columbia-Victoria Medical Campus, Island Medical Program, University of Victoria, 3800 Finnerty Road, Victoria, BC V8N-1M5, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Copen
authors.affiliation: Department of Medical Biophysics, Schulich School of Medicine & Dentistry University of Western Ontario, London, ON N6G 4X8, Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Bureau
authors.affiliation: Certificate Professional Qualification (CPQ), Clinical Psychology, Association of State and Provincial Psychology Board (ASPB): USA and Canada.
authors.forename: Zack
authors.initials: Z
authors.lastname: Cernovsky
authors.affiliation: Epigenetics Research Group, Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
authors.forename: J Jurui
authors.initials: JJ
authors.lastname: Hou
authors.affiliation: Epigenetics Research Group, Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
authors.forename: Hana
authors.initials: H
authors.lastname: Raheb
authors.affiliation: Accelerated B.Sc.N. Nursing Program, Lawrence S. Bloomberg, Faculty of Nursing, University of Toronto, 155 College Street, Suite 130 Toronto, ON M5T 1P8, Canada.
authors.forename: Kristen
authors.initials: K
authors.lastname: Terpstra
authors.affiliation: McGill University, Meakins-Christie Labs, 3626 St., Urbain Street, Montreal, QC H2X 2P2, Canada.
authors.forename: Veronica
authors.initials: V
authors.lastname: Sanchez
authors.affiliation: Geriatric Psychiatry Division, St. Joseph's Healthcare Hamilton /McMaster University Health Sciences, West 5th Campus 100 West 5th Hamilton, ON L8N 3K7, Canada.
authors.forename: Ana
authors.initials: A
authors.lastname: Hategan
authors.affiliation: Epigenetics Research Group, Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
authors.forename: Mike
authors.initials: M
authors.lastname: Kaushal
authors.affiliation: Department of Psychiatry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6G 4X8, Canada.
authors.forename: Robbie
authors.initials: R
authors.lastname: Campbell
mesh_terms: D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D004032:Diet / Q000379:methods*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications / Q000235:genetics* / Q000503:physiopathology
keywords: Alzheimer dementia; Cognition; Epigenetics diet; Nutraceuticals; Stress