title: [Molecular basis of circadian rhythms and principles of circadian disruption].
abstract: Current knowledge of core molecular mechanisms of circadian system is reviewed with intent look at consequences of pleiotropic effects of phase and amplitude disturbances in rhythmic expression of genome-transcriptome-proteome elements in development of desynchronized phenotypic functions. Multiple adverse implications of compromised circadian synchronization for health and longevity are discussed. Concept of extracircadian dissemination of output physiological functions as a general feature of phenotypic circadian disorder is PRESENTED.
authors.forename: D G
authors.initials: DG
authors.lastname: Gubin
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins; D035683:MicroRNAs