title: Long-term survival following total pancreatectomy and superior mesenteric-portal vein resection for pancreatic ductal adenocarcinoma: A case report.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with few therapeutic options. At present, surgical resection remains the only potential curative treatment for PDAC. However, only 15-20% of patients with PDAC are eligible for lesion resection. Total pancreatectomy (TP) and superior mesenteric-portal vein resection (SMPVR) may increase the rate of resection of PDCA, but the effect of this approach on improving long-term patient outcomes remains controversial. The present study investigated a case of PDAC in the pancreatic neck of a male patient. The patient underwent a TP, combined with SMPVR, for a margin-negative resection. Following an uneventful post-operative recovery, the patient received adjuvant chemoradiotherapy. The patient is currently alive at six years post-surgery, with a high quality of life. Given the clinical outcome of this patient, TP combined with SMPVR may provide PDAC patients with an opportunity for long-term survival. Therefore, patients with PDAC that is believed to be unresectable based on pre-operative assessment, may benefit from TP and SMPVR.
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Han-Xing
authors.initials: HX
authors.lastname: Tong
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Ye-Fei
authors.initials: YF
authors.lastname: Rong
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Dan-Song
authors.initials: DS
authors.lastname: Wang
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Tian Tao
authors.initials: TT
authors.lastname: Kuang
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Xu
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Lou
authors.affiliation: Pancreatic Cancer Group, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: DA-Yong
authors.initials: DY
authors.lastname: Jin
keywords: long-term survival; pancreatic ductal adenocarcinoma; superior mesenteric-portal vein resection