title: Transcranial color flow imaging can evaluate the severity of periventricular hyperintensity.
abstract: BACKGROUND
  The goal of this study was to investigate the relationship between white matter lesions on magnetic resonance imaging and flow parameters in the middle cerebral artery (MCA) measured by transcranial color flow imaging.
  
  
  METHODS
  Patients with acute ischemic stroke or transient ischemic attack were included. The relationship between severities of periventricular hyperintensity (PVH) and ultrasonographic parameters in the MCA was investigated. The frequency of PVH was calculated for different categories according to the presence or absence of 2 considerable parameters according to the value of area under the receiver operating characteristic curve.
  
  
  RESULTS
  MCA flow was successfully measured in 203 temporal windows among 124 patients. After determining the cutoff value of end-diastolic velocity (EDV) and pulsatility index (PI) for the presence of PVH, 4 different categories were established: Category A, EDV more than 40 cm/second and PI less than .7; Category B, EDV more than 40 cm/second and PI more than .7; Category C, EDV less than 40 cm/second and PI less than .7; and Category D, EDV less than 40 cm/second and PI more than .7. The prevalence of PVH gradually increased along with category (P < .01).
  
  
  CONCLUSIONS
  The evaluation of MCA parameters using the combination of PI and EDV may be useful for the prediction of PVH.
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: hmitsumura@jikei.ac.jp.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Mitsumura
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Miyagawa
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Komatsu
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kono
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furuhata
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Iguchi
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D020521:Stroke / Q000000981:diagnostic imaging; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D066127:White Matter / Q000000981:diagnostic imaging
keywords: White matter lesion; end-diastolic velocity; middle cerebral artery; periventricular hyperintensity; pulsatility index; transcranial color flow imaging