title: Fetal programming, epigenetics, and adult onset disease.
abstract: How early life events program adult disease is undergoing a transition from the broad field of maternal malnutrition to the current relevant issues of food deserts and prematurity. Although many adult diseases and morbidities associate with various early life events and programming, the morbidities of insulin resistance, cardiovascular disease, and obesity seem to be common end points of many early life events despite potential confounders.
authors.affiliation: Department of Pediatrics, Children's Hospital of Wisconsin, Medical College of Wisconsin, Suite 720, PO Box 1997, Milwaukee, WI 53201-1997, USA. Electronic address: rlane@mcw.edu.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lane
mesh_terms: D000328:Adult; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D047109:Fetal Development / Q000235:genetics*; D005523:Food Supply; D059647:Gene-Environment Interaction; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics*
keywords: DNA methylation; Developmental origins of disease; Epigenetics; Food desert; Histone covalent modifications; Insulin growth factor 1; Insulin resistance; Obesity