title: Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties.
abstract: Nano-hydroxyapatite/polyacrylamide composite hydrogels were successfully fabricated by physically mixing nano-hydroxyapatite (nHAp) particles into a peroxidized micelles initiated and cross-linked (pMIC) polyacrylamide (PAAm) hydrogel. The nanocomposite hydrogels exhibited excellent mechanical properties. The fracture tensile stresses of the gels were in the range of 0.21-0.86 MPa and the fracture tensile strains were up to 30 mm/mm, and the compressive strengths were up to 35.8 MPa. Meanwhile the introduction of nHAp endowed the composite hydrogels with good cell adhesion properties. This nHAp/PAAm nanocomposite hydrogel is expected to find potential applications in tissue engineering.
authors.affiliation: College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Mi
authors.affiliation: College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China.
authors.forename: Huiliang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Yunlan
authors.initials: Y
authors.lastname: Su
authors.affiliation: College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China. Electronic address: herbert@bnu.edu.cn.
authors.forename: Changcheng
authors.initials: C
authors.lastname: He
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D017886:Durapatite / Q000737:chemistry*; D020100:Hydrogels / Q000009:adverse effects / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D017886:Durapatite; D020100:Hydrogels; D000099166:Polyacrylamides
keywords: Composite hydrogel; Hydroxyapatite; Mechanical property; Polyacrylamide; Tissue engineering