title: Benzodioxane-benzamides as new bacterial cell division inhibitors.
abstract: A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chiodini
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Pallavicini
authors.affiliation: Department of Medical Biothechnologies and Translational Medicine, Università di Milano, Via Vanvitelli 32, I-20129 Milano, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Zanotto
authors.affiliation: Department of Pharmacological and Biomolecular Sciences, Università di Milano, Via Balzaretti 9, I-2013 Milano, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bissa
authors.affiliation: Department of Pharmacological and Biomolecular Sciences, Università di Milano, Via Balzaretti 9, I-2013 Milano, Italy; CNR Institute of Neurosciences, Cellular and Molecular Pharmacology Section, Università di Milano, Via Vanvitelli 32, I-20129 Milano, Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Radaelli
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Straniero
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Bolchi
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Fumagalli
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Ruggeri
authors.affiliation: Department of Medical Biothechnologies and Translational Medicine, Università di Milano, Via Vanvitelli 32, I-20129 Milano, Italy; CNR Institute of Neurosciences, Cellular and Molecular Pharmacology Section, Università di Milano, Via Vanvitelli 32, I-20129 Milano, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: De Giuli Morghen
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133 Milano, Italy. Electronic address: ermanno.valoti@unimi.it.
authors.forename: Ermanno
authors.initials: E
authors.lastname: Valoti
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors; D004146:Dioxanes / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001549:Benzamides; D003598:Cytoskeletal Proteins; D004146:Dioxanes; C071525:FtsZ protein, Bacteria; C531944:PC190723; D011725:Pyridines; D013844:Thiazoles; C078231:2,6-difluorobenzamide; C527681:1,4-benzodioxan
keywords: 2,6-Difluorobenzamide; Antibacterial activity; Benzodioxane; FtsZ; Staphylococcus aureus