title: Inflammation-induced DNA damage and damage-induced inflammation: a  vicious cycle.
abstract: Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific binding proteins to instigate pro-inflammatory response. Some of these DNA binding proteins also participate in canonical DNA repair pathways and recognise damaged DNA to initiate DNA damage response. In this review we aim to capture the essence of the complex interplay between DNA damage response and the pro-inflammatory signalling through representative examples.
authors.affiliation: School of Life Sciences, University of Lincoln, Brayford Pool, Lincoln, Lincolnshire LN6 7TS, United Kingdom.
authors.forename: Timea
authors.initials: T
authors.lastname: Pálmai-Pallag
authors.forename: Csanád Z
authors.initials: CZ
authors.lastname: Bachrati
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004272:DNA, Mitochondrial / Q000378:metabolism; D004195:Disease Models, Animal; D042822:Genomic Instability; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D009154:Mutation; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D004272:DNA, Mitochondrial; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D051192:Receptors, Pattern Recognition