title: Neisseria meningitidis: pathogenesis and immunity.
abstract: The recent advances in cellular microbiology, genomics, and immunology has opened new horizons in the understanding of meningococcal pathogenesis and in the definition of new prophylactic intervention. It is now clear that Neissera meningitidis has evolved a number of surface structures to mediate interaction with host cells and a number of mechanisms to subvert the immune system and escape complement-mediated killing. In this review we report the more recent findings on meningococcal adhesion and on the bacteria-complement interaction highlighting the redundancy of these mechanisms. An effective vaccine against meningococcus B, based on multiple antigens with different function, has been recently licensed. The antibodies induced by the 4CMenB vaccine could mediate bacterial killing by activating directly the classical complement pathway or, indirectly, by preventing binding of fH on the bacterial surface and interfering with colonization.
authors.affiliation: Novartis Vaccines, Siena, Italy. Electronic address: mariagrazia.pizza@novartis.com.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Pizza
authors.affiliation: Novartis Vaccines, Siena, Italy.
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D001422:Bacterial Adhesion; D001770:Blood Bactericidal Activity; D003165:Complement System Proteins; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D008589:Meningococcal Infections / Q000276:immunology / Q000473:pathology; D009345:Neisseria meningitidis / Q000276:immunology* / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D003165:Complement System Proteins