title: Bioactive triterpenoid saponins and phenolic compounds against glioma cells.
abstract: A total of 54 natural origin compounds were evaluated for their activity in inhibiting the proliferation of glioma cells. Results showed that four Aesculus polyhydroxylated triterpenoid saponins (3-6), six Gleditsia triterpenoid saponins (7-12), and five phenolic compounds (43-46, 51) had dose-dependent activity suppressing the proliferation of both C6 and U251 cells. Structure-activity relationship analysis suggested that the acetyl group at C-28 for the Aesculus saponins and the monoterpenic acid moiety for the Gleditsia saponins could be critical for the activity of these active compounds. Aesculioside H (4), gleditsioside A (7), and feuric acid 3,4-dihydroxyphenethyl ester (FADPE, 46) were the three most active compounds from the different types of the active compounds and induced apoptosis and necrosis in glioma cells.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Ye
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Siran
authors.initials: S
authors.lastname: Yu
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Haocai
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: xylian@zju.edu.cn.
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Lian
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. Electronic address: zzhang88@zju.edu.cn.
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005910:Glioma; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010636:Phenols; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes
keywords: Inhibition of glioma cell proliferation; Phenolic compounds; Triterpenoid saponins