title: Molecular pathways of mitochondrial dysfunctions: possible cause of cell death in anesthesia-induced developmental neurotoxicity.
abstract: The effect of anesthesia on the developing brain has attracted more attention and arguments. This review summarizes various studies on developmental neurotoxicity induced by anesthesia, particularly focuses on the function of the mitochondrial dysfunction. Experimental results present evidence that general anesthesia can cause mitochondrial dysfunction via complex pathways, including oxidative stress, electron transport chain dysfunction, mitochondrial dynamics, calcium homeostasis, and mitochondrion-dependent apoptotic pathway. Hence, the molecular processes of mitochondrial dysfunction should be understood to develop novel therapeutic strategies that can prevent anesthesia-induced neurotoxicity and provide neuroprotection against developmental central nervous system.
authors.affiliation: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China. Electronic address: mazuilili@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China. Electronic address: yu.qiong816@gmail.com.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China. Electronic address: chiefliang@sina.com.
authors.forename: Weimin
authors.initials: W
authors.lastname: Liang
mesh_terms: D000777:Anesthetics / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D020258:Neurotoxicity Syndromes / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D000777:Anesthetics; D002118:Calcium
keywords: Anesthesia; Developing brain; Mitochondrial dysfunction; Neurotoxicity