title: The molecular mechanism of rhein in diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is characterized by unclear pathogenesis. Recent medical data shows that the incidence of DN rises year by year. Rhein is the main compositions of rhubarb, a traditional Chinese medicinal plant, which plays an active role in kidney protection. The prophylaxis and phytotherapeutic effects of rhein are due to its anti-inflammatory and antifibrosis properties. Here, we shed light on the renal protective role of rhein in diabetes mellitus (DM) with a particular focus on the molecular basis of this effect.
authors.affiliation: Department of Nephrology, The Wenzhou Traditional Chinese Medicine Affiliated Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Zeng
authors.affiliation: Department of Nephrology, The Wenzhou Traditional Chinese Medicine Affiliated Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
authors.affiliation: Department of Nephrology, The Wenzhou Traditional Chinese Medicine Affiliated Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Qian-Jia
authors.initials: QJ
authors.lastname: Wu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.
authors.forename: Wang-Wang
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Department of Nephrology, The Wenzhou Traditional Chinese Medicine Affiliated Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Luo
authors.affiliation: Department of Nephrology, The Wenzhou Traditional Chinese Medicine Affiliated Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Jin-Guo
authors.initials: JG
authors.lastname: Cheng