title: Five new phenolic compounds from Dendrobium aphyllum.
abstract: One new phenanthrene, aphyllone A (1) and four new bibenzyl derivatives, aphyllone B (2) and aphyllals C-D (3-5), together with nine known compounds (6-14), were isolated from the stems of Dendrobium aphyllum (Roxb.) C. E. Fischer. The structures of these new compounds were elucidated by means of extensive spectroscopic analyses, and the absolute configuration of compound 1 was determined by single crystal X-ray diffraction and quantum calculations. Compounds 6, 8 and 14 inhibited NO production at the concentration of 25 μM in LPS-stimulated RAW264.7 cells with the inhibition (%) of 32.48, 35.68, and 38.50. Compound 2 possessed significant DPPH radical scavenging activity with scavenging percentage of 87.97% at the concentration of 100 μg/mL.
authors.affiliation: School of Chemical Sciences and Technology of Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guilin Normal College, Guilin 541001, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: College of Agronomy and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Liang-Yan
authors.initials: LY
authors.lastname: Liu
authors.affiliation: Guilin Normal College, Guilin 541001, PR China.
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Feng-Qing
authors.initials: FQ
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Fan
authors.affiliation: School of Chemical Sciences and Technology of Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Cheng-Ting
authors.initials: CT
authors.lastname: Zi
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Fa-Wu
authors.initials: FW
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Chemical Sciences and Technology of Yunnan University, Kunming 650091, PR China. Electronic address: ztding@ynu.edu.cn.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: hujiangmiao@mail.kib.ac.cn.
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
mesh_terms: D000818:Animals; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D045744:Cell Line, Tumor; D031667:Dendrobium / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry
chemical_list: D001632:Bibenzyls; D016166:Free Radical Scavengers; D010616:Phenanthrenes; D010636:Phenols; D009569:Nitric Oxide
keywords: Batatasin III (PubChem CID: 10466989); Bibenzyl derivative; Dendrobium aphyllum; Dihydroresveratrol (PubChem CID: 185914); Gigantol (PubChem CID: 10221179); Hircinol (PubChem CID: 442705); Moscatilin (PubChem CID: 176096); Moscatin (PubChem CID: 194774); NO production; Phenanthrene; Tristin (PubChem CID: 15736297)