title: Curcumin: a pleiotropic phytonutrient in diabetic complications.
abstract: Curcumin is the major polyphenolic constituent of an indigenous herb, Curcuma longa, found to have a wide range of applications right from its kitchen use as a spicy ingredient to therapeutic and medicinal applications in various diseases. Curcumin has been identified to have a plethora of biologic and pharmacologic properties owing to its antioxidant and anti-inflammatory activities. This pleiotropic regulation of redox balance of cell and inflammation might be the basis of curcumin's beneficial activities in various pathologic conditions including diabetic complications. This review summarizes various in vitro, in vivo studies done on curcumin and its therapeutic utility in diabetic micro-vascular complications. This review also emphasizes the importance of curcumin in addition to the existing therapeutic modalities in diabetic complications.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India.
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Jeenger
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India.
authors.forename: Shweta
authors.initials: S
authors.lastname: Shrivastava
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India.
authors.forename: Veera Ganesh
authors.initials: VG
authors.lastname: Yerra
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India.
authors.forename: V G M
authors.initials: VG
authors.lastname: Naidu
authors.affiliation: Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: Sistla
authors.initials: S
authors.lastname: Ramakrishna
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India. Electronic address: Ashutosh@niper.ac.in.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology*; D048909:Diabetes Complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D064209:Phytochemicals / Q000494:pharmacology*; D017365:Spices
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D064209:Phytochemicals; D003474:Curcumin
keywords: Curcumin; Diabetic complications; Nephropathy; Neuropathy; Retinopathy