title: New supramolecular metallo-terpyridine carboxymethyl cellulose derivatives with antimicrobial properties.
abstract: Preparation of a new water-soluble, cellulose derivative via a supramolecular route is presented. In a one-step procedure, carboxymethyl cellulose (CMC) was reacted with the Cu(BF4)2 complex of 4'-chloro[2,2':6',2″]terpyridine to generate the desired CMC-Cu(II)-terpyridine derivative. This polymeric salt was characterized by elemental analysis, ultraviolet-visible spectroscopy (UV-visible), Fourier transform infrared (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), rheological properties measurements, thermogravimetric analysis (TGA), dynamic mechanical thermal analysis (DMTA), and tensile strength properties testing. In addition, antimicrobial properties were demonstrated against Gram-positive bacteria (Staphylococcus aureus and Streptococcus thermophilus), Gram-negative bacteria (Escherichia coli), and yeast (Saccharomyces cervisiae). The minimum inhibitory concentration of the prepared metallo-terpyridine CMC derivative against the studied microorganisms ranged from 6 to 8 mg/L to achieve ≥90% of microbial growth inhibition.
authors.affiliation: Cellulose and Paper Department, National Research Centre, Dokki, Giza 12622, Egypt.
authors.forename: Enas A
authors.initials: EA
authors.lastname: Hassan
authors.affiliation: Cellulose and Paper Department, National Research Centre, Dokki, Giza 12622, Egypt; Centre of Excellence for Advanced Sciences, Advanced Materials and Nanotechnology Group, National Research Centre, Dokki, Giza 12622, Egypt. Electronic address: mlhassan2012@yahoo.com.
authors.forename: Mohammad L
authors.initials: ML
authors.lastname: Hassan
authors.affiliation: Department of Polymer Science, The University of Akron, Akron, OH 44325, USA.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Moorefield
authors.affiliation: Department of Polymer Science, The University of Akron, Akron, OH 44325, USA; Department of Chemistry, The University of Akron, Akron, OH 44325, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Newkome
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D011725:Pyridines; D003300:Copper; D002266:Carboxymethylcellulose Sodium
keywords: Antimicrobial; Carboxymethyl cellulose; Supramolecular; Terpyridine