title: Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.
abstract: Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression, distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of sarcomeric proteins have been implicated to play a role in the onset and development of human heart failure. In this mini-review, we summarized isoform transitions of several most widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin and myosin binding protein-C, and the consequence of these abnormal isoform transitions. Even though the isoform transitions of sarcomeric proteins have been described in individual sarcomeric protein reviews, no concise summary of these results has been presented previously. This review is intended to fill this gap and discuss possible future perspectives.
authors.affiliation: Animal Science, College of Agriculture and Natural Resources, University of WY, Laramie WY82071, USA; Department of Cardiology, Xi Jing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Center for Cardiovascular Research and Alternative Medicine, College of Health Science, University of WY, Laramie WY82071, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Animal Science, College of Agriculture and Natural Resources, University of WY, Laramie WY82071, USA; Center for Cardiovascular Research and Alternative Medicine, College of Health Science, University of WY, Laramie WY82071, USA. Electronic address: wguo3@uwyo.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism*; D012518:Sarcomeres / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins; D020033:Protein Isoforms
keywords: Alternative splicing; Heart failure; Protein isoform transition; Sarcomere proteins