title: Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study.
abstract: OBJECTIVE
  To evaluate the relationship between polycystic ovarian morphology (PCOM) and oocyte quality after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Prospective, comparative study with concurrently treated and age-matched controls.
  
  
  METHODS
  Academic IVF unit of the Lille University Hospital.
  
  
  METHODS
  A total of 194 women were prospectively included before their first IVF-ICSI attempt for exclusive male infertility. They were classified into PCOM (n = 97) or control groups (n = 97) according to their follicle number per ovary. The nuclear maturation and morphologic aspects of 1,013 oocytes from PCOM patients were assessed and compared with those of 774 oocytes from controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Rate of metaphase II (MII) and morphologically abnormal oocytes.
  
  
  RESULTS
  The mean number of total and MII oocytes retrieved was significantly higher in the PCOM group. The rate of MII and morphologically abnormal oocytes was equivalent between the two groups. The mean number of embryos was significantly higher in the PCOM group. However, the percentage of top-quality embryos on day 3 was similar between the two groups. The implantation and clinical pregnancy rates were significantly higher in the PCOM group.
  
  
  CONCLUSIONS
  Polycystic ovarian morphology does not have a negative impact on the quality of oocytes and embryos or the outcome of IVF-ICSI.
authors.affiliation: EA 4308 Gamétogenèse et qualité du gamète, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France. Electronic address: christine.decanter@chru-lille.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Sigala
authors.affiliation: Service d'Histologie-Embryologie-Cytogénétique-CECOS, Hôpital Jean Verdier (AP-HP), Centre Hospitalier Universitaire, Bondy, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Sifer
authors.affiliation: Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Dewailly
authors.affiliation: Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Robin
authors.affiliation: Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Bruyneel
authors.affiliation: Centre d'Etudes et de Recherche en Informatique Médicale, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Nassima
authors.initials: N
authors.lastname: Ramdane
authors.affiliation: EA 4308 Gamétogenèse et qualité du gamète, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Lefebvre-Khalil
authors.affiliation: EA 4308 Gamétogenèse et qualité du gamète, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Mitchell
authors.affiliation: Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional et Universitaire, Lille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Decanter
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D009865:Oocytes / Q000473:pathology*; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D055815:Young Adult
keywords: IVF; PCOM; PCOS; oocyte morphology; oocyte quality