title: Comparative pathology of canine soft tissue sarcomas: possible models of human non-rhabdomyosarcoma soft tissue sarcomas.
abstract: Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other's interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models.
authors.affiliation: Department of Clinical Sciences, Oregon State University, Corvallis, Oregon, USA. Electronic address: milan.milovancev@oregonstate.edu.
authors.forename: M
authors.initials: M
authors.lastname: Milovancev
authors.affiliation: Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hauck
authors.affiliation: Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA; Children's Cancer Therapy Development Institute (cc-TDI), Fort Collins, CO 80524, USA.
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.affiliation: Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: L W
authors.initials: LW
authors.lastname: Stranahan
authors.affiliation: Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mansoor
authors.affiliation: Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Malarkey
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D007150:Immunohistochemistry; D012509:Sarcoma / Q000473:pathology* / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: comparative pathology; dog; man; soft tissue sarcoma