title: Binary behaviour of an oxidation-responsive MRI nano contrast agent.
abstract: A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 μM), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non-linear cascade relation between extent of oxidation and water permeability in the particles.
authors.affiliation: Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Damien
authors.initials: D
authors.lastname: Jeanmaire
authors.forename: Grigore A
authors.initials: GA
authors.lastname: Timco
authors.forename: Arianna
authors.initials: A
authors.lastname: Gennari
authors.forename: Stephen
authors.initials: S
authors.lastname: Sproules
authors.forename: Kaye J
authors.initials: KJ
authors.lastname: Williams
authors.forename: Richard E P
authors.initials: RE
authors.lastname: Winpenny
authors.forename: Nicola
authors.initials: N
authors.lastname: Tirelli
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D003287:Contrast Media