title: Evaluation of the relationship between serum ghrelin, C-reactive protein and interleukin-6 levels, and disease activity in inflammatory bowel diseases.
abstract: OBJECTIVE
  Ghrelin is a 28 aminoasid peptide hormone, have generally focused upon this peptide’s role upon growth and energy metabolism. Recently, studies investigating ghrelin’s effect upon inflammation and immune response have gained importance. We aimed to compare the effectiveness of ghrelin levels, Creactive protein and interleukin-6 levels in establishing disease activity.
  
  
  METHODS
  52 cases with ulcerative colitis and 33 with Crohn’s disease, total 85 patients, were included in this study. The serum ghrelin levels of the patients in remission and of those with active disease were compared.
  
  
  RESULTS
  The mean serum ghrelin level in active patients (1243 ± 648 pg/ml), was found to be higher than those in remission (466 ± 214 pg/ml) (p<0.001). In establishing the disease activity, CRP is a the most effective marker compared to the other two inflammatory markers. AUC values were established as; CRP: 0.947 (95% CI,0.903-0.992),ghrelin:0.934(95% CI, 0.884-0.984) and interleukin-6: 0.756 (95% CI, 0.648- 0.864).
  
  
  CONCLUSIONS
  Serum ghrelin level can be used with CRP as an important marker in establishing the mucosal damage in inflammatory bowel diseases.
authors.forename: Cem
authors.initials: C
authors.lastname: Cekic
authors.forename: Mahmut
authors.initials: M
authors.lastname: Arabul
authors.forename: Emrah
authors.initials: E
authors.lastname: Alper
authors.forename: Zehra Betul Kocal
authors.initials: ZB
authors.lastname: Pakoz
authors.forename: Elif
authors.initials: E
authors.lastname: Saritas
authors.lastname: Yuksel
authors.forename: Belkis
authors.initials: B
authors.lastname: Ünsal
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D003424:Crohn Disease / Q000097:blood* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C515349:GHRL protein, human; D054439:Ghrelin; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D002097:C-Reactive Protein