title: High-dose re-irradiation following radical radiotherapy for non-small-cell lung cancer.
abstract: As the prognosis of lung cancer patients improves, more patients are at risk of developing local recurrence or a new primary tumour in previously irradiated areas. Technological advances in radiotherapy and imaging have made treatment of patients with high-dose re-irradiation possible, with the aim of long-term disease-free survival and even cure. However, high-dose re-irradiation with overlapping volumes of previously irradiated tissues is not without risks. Late, irreversible, and potentially serious normal tissue damage may occur because of injury to surrounding thoracic structures and organs at risk. In this Review, we aimed to report the efficacy and toxic effects of high-dose re-irradiation for locoregional recurrent non-small-cell lung cancer. Our findings indicate that high-dose re-irradiation might be beneficial in selected patients; however, patients and physicians should be aware of the scarcity of high-quality data when considering this treatment.
authors.affiliation: Radiation Oncology, University Hospitals Leuven/KU Leuven, Leuven, Belgium. Electronic address: dirk.deruysscher@uzleuven.be.
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ruysscher
authors.affiliation: Radiation Related Research, The Christie NHS Foundation Trust and University of Manchester, Manchester, UK.
authors.forename: Corinne
authors.initials: C
authors.lastname: Faivre-Finn
authors.affiliation: Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France.
authors.forename: Cecile
authors.initials: C
authors.lastname: Le Pechoux
authors.affiliation: Radiation Oncology, University Hospitals Leuven/KU Leuven, Leuven, Belgium.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Peeters
authors.affiliation: Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.
authors.forename: José
authors.initials: J
authors.lastname: Belderbos
mesh_terms: D001918:Brachytherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D019233:Retreatment