title: Nanomedicines for antimicrobial interventions.
abstract: The development of new antimicrobial therapeutic tools addresses the emergence of multidrug-resistant micro-organisms or clones and the need for more effective antimicrobial strategies. Overcoming the hurdles in providing early diagnosis and intervention on hard-to-reach and/or resting bacteria (i.e. biofilm-embedded cells) represents a challenging task. In this review, we identify a set of organic, inorganic, and hybrid materials that might be used for prevention and control of healthcare-associated infections. We report the current knowledge on nano- and microparticle-based antimicrobial agents and describe the possible mode of their action.
authors.affiliation: Dipartimento di Scienze e Tecnologie Chimiche, Università degli studi di Roma Tor Vergata, Roma, Italy. Electronic address: francesca.cavalieri@uniroma2.it.
authors.forename: F
authors.initials: F
authors.lastname: Cavalieri
authors.affiliation: Dipartimento di Scienze e Tecnologie Chimiche, Università degli studi di Roma Tor Vergata, Roma, Italy; Istituto di Biochimica delle Proteine-IBP, CNR, Napoli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tortora
authors.affiliation: Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanità, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Stringaro
authors.affiliation: Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanità, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colone
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Roma, Italy. Electronic address: lucilla.baldassarri@iss.it.
authors.forename: L
authors.initials: L
authors.lastname: Baldassarri
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry; D050997:Nanomedicine; D011108:Polymers / Q000737:chemistry; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D011108:Polymers; D012834:Silver
keywords: Antimicrobial micro/nanosystems; Gold nanoparticles; Lipid nanoparticles; Microbubbles; Polymeric materials; Silver nanoparticles