title: Clinical application of plasma thermograms. Utility, practical approaches and considerations.
abstract: Differential scanning calorimetry (DSC) studies of blood plasma are part of an emerging area of the clinical application of DSC to biofluid analysis. DSC analysis of plasma from healthy individuals and patients with various diseases has revealed changes in the thermal profiles of the major plasma proteins associated with the clinical status of the patient. The sensitivity of DSC to the concentration of proteins, their interactions with other proteins or ligands, or their covalent modification underlies the potential utility of DSC analysis. A growing body of literature has demonstrated the versatility and performance of clinical DSC analysis across a range of biofluids and in a number of disease settings. The principles, practice and challenges of DSC analysis of plasma are described in this article.
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, KY 40202, USA. Electronic address: nichola.garbett@louisville.edu.
authors.forename: Nichola C
authors.initials: NC
authors.lastname: Garbett
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: Chongkham S
authors.initials: CS
authors.lastname: Mekmaysy
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: DeLeeuw
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Chaires
mesh_terms: D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002152:Calorimetry, Differential Scanning / Q000379:methods*; D019937:Diagnostic Techniques and Procedures; D010949:Plasma / Q000378:metabolism*; D013696:Temperature; D013816:Thermodynamics
chemical_list: D015415:Biomarkers; D001798:Blood Proteins
keywords: Clinical diagnostics; Differential scanning calorimetry; Plasma; Thermogram