title: Human metapneumovirus pneumonia in patients with hematological malignancies.
abstract: BACKGROUND
  Human metapneumovirus (HMPV) has recently emerged as a cause of respiratory infections in hematological patients. Clinical data are lacking to guide the management of HMPV pneumonias.
  
  
  OBJECTIVE
  To characterize the clinical and radiographic presentation and outcome of HMPV pneumonias diagnosed in hematological patients.
  
  
  METHODS
  We screened the patients with a positive HMPV respiratory test in two French teaching hospitals between 2007 and 2011. Among them, the medical charts from the hematological patients who presented with HMPV pneumonia were reviewed.
  
  
  RESULTS
  Among the 54 patients with several underlying hematological conditions who were positive for HMPV, we found 13 cases of HMPV pneumonias. HMPV could be the cause of pneumonia as a single pathogen without associated upper respiratory infection. Centrilobular nodules were constant on lung computed tomography scans. No patients died despite the absence of administration of antiviral treatments.
  
  
  CONCLUSIONS
  Our data provide further insights in the diagnosis and management of HMPV pneumonias in this setting.
authors.affiliation: Service de Maladies Infectieuses et de Médecine Interne, CHU Poitiers, France.
authors.forename: Cendrine
authors.initials: C
authors.lastname: Godet
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire de microbiologie, AP-HP, Hôpital Saint Louis, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Le Goff
authors.affiliation: Service de Virologie, CHU Poitiers, Université de Poitiers, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Beby-Defaux
authors.affiliation: Univ Paris Diderot, Sorbonne Cité, Service d'Hématologie-Greffe, AP-HP, Hôpital Saint Louis, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.affiliation: Univ Paris Diderot, Sorbonne Cité, Maladies du sang, AP-HP, Hôpital Saint Louis, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Raffoux
authors.affiliation: Univ Paris Diderot, Sorbonne Cité, Service d'Immuno-Hématologie, AP-HP, Hôpital Saint Louis, Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Arnulf
authors.affiliation: Service de Maladies Infectieuses et de Médecine Interne, CHU Poitiers, France.
authors.forename: France
authors.initials: F
authors.lastname: Roblot
authors.affiliation: Service de Réanimation Médicale, CHU Poitiers, France.
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Frat
authors.affiliation: Service d'Hématologie, CHU Poitiers, France.
authors.forename: Natacha
authors.initials: N
authors.lastname: Maillard
authors.affiliation: Biostatistics and Clinical Epidemiology Research Team (ECSTRA), UMR 1153 INSERM, Univ Paris Diderot, Sorbonne Paris Cité, France; AP-HP, Hôpital Saint-Louis, Service de Pneumologie, F-75010 Paris, France.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Tazi
authors.affiliation: Biostatistics and Clinical Epidemiology Research Team (ECSTRA), UMR 1153 INSERM, Univ Paris Diderot, Sorbonne Paris Cité, France; AP-HP, Hôpital Saint-Louis, Service de Pneumologie, F-75010 Paris, France. Electronic address: anne.bergeron@sls.aphp.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Bergeron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D005260:Female; D005602:France; D019337:Hematologic Neoplasms / Q000150:complications*; D006784:Hospitals, Teaching; D006801:Humans; D016867:Immunocompromised Host; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification*; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D014057:Tomography, X-Ray Computed
keywords: Emerging virus; Hematological patients; Immunocompromised; Metapneumovirus; Respiratory infection