title: Outcome of pregnancy in chronic myeloid leukaemia patients treated with tyrosine kinase inhibitors: short report from a single centre.
abstract: BACKGROUND
  The aim of this work was to report on the outcome of pregnancy in patients with chronic myeloid leukaemia who were on tyrosine kinase inhibitor treatment.
  
  
  METHODS
  We report the result of 22 pregnancies in 14 patients (9 female and 5 male) who conceived or their partner conceived while being on tyrosine kinase inhibitors for their CML.
  
  
  RESULTS
  All pregnancies except one were uneventful. 25 newborns were born and except in one case where small atrial septal defect was diagnosed, all infants were healthy and showed normal development after birth.
  
  
  CONCLUSIONS
  This small series does indicate that parents can most likely expect an uneventful outcome to a pregnancy despite exposure of either partner to TKIs. There is no consensus or guideline regarding the best practice in case of pregnancy. More reports of similar nature would certainly be beneficial to practitioners and patients alike. As such it is still recommended to practice effective contraception during the period of TKI treatment.
authors.affiliation: Department of Medicine, Division of Haematology-Oncology, Kaposi Mór Teaching Hospital in affiliation with Pécs University, Kaposvár, Hungary; Department of Oncology, Tawam Hospital in affiliation with Johns Hopkins Medicine, AlAin, United Arab Emirates; Department of Haematology, Mercy University Hospital, Cork, Ireland. Electronic address: alizadeh.hussain@pte.hu.
authors.forename: H
authors.initials: H
authors.lastname: Alizadeh
authors.affiliation: Department of Oncology, Tawam Hospital in affiliation with Johns Hopkins Medicine, AlAin, United Arab Emirates.
authors.forename: H
authors.initials: H
authors.lastname: Jaafar
authors.affiliation: Department of Medicine, Division of Haematology-Oncology, Kaposi Mór Teaching Hospital in affiliation with Pécs University, Kaposvár, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Rajnics
authors.affiliation: Department of Haematology, Mercy University Hospital, Cork, Ireland.
authors.forename: M I
authors.initials: MI
authors.lastname: Khan
authors.affiliation: Department of Pathology, Faculty of General Medicine, Pécs University, Pécs, Hungary.
authors.forename: B
authors.initials: B
authors.lastname: Kajtár
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000201:enzymology; D011256:Pregnancy Outcome; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*
chemical_list: D047428:Protein Kinase Inhibitors
keywords: Chronic myeloid leukaemia; Outcome; Pregnancy; Tyrosine kinase inhibitors