title: [Glaucoma medications, preservatives and the ocular surface.]
abstract: Several clinical and experimental studies have demonstrated that ocular surface disease is common in glaucoma patients receiving chronic glaucoma drops, and that the preservatives in these drops play a major role in the occurrence of ocular surface disease. These ocular surface changes may induce both symptoms reported by the patients and anterior segment clinical signs, and should be systematically assessed by history and exam in all glaucoma patients. In these patients with ocular surface disease, reducing the amount of preservatives administered to the eye should be strived for, rather than adding additional eye drops to alleviate or mask the side effects of the glaucoma drops.
authors.affiliation: Centre hospitalier universitaire, boulevard de la Chantourne, 38700 La Tronche, France. Electronic address: faptel@chu-grenoble.fr.
authors.forename: F
authors.initials: F
authors.lastname: Aptel
authors.affiliation: Centre hospitalier national d'ophtalmologie des Quinze-Vingts, 75012 Paris, France; Hôpital Ambroise-Paré (AP-HP), 92100 Boulogne-Billancourt, France.
authors.forename: A
authors.initials: A
authors.lastname: Labbé
authors.affiliation: Centre hospitalier national d'ophtalmologie des Quinze-Vingts, 75012 Paris, France; Hôpital Ambroise-Paré (AP-HP), 92100 Boulogne-Billancourt, France.
authors.forename: C
authors.initials: C
authors.lastname: Baudouin
authors.affiliation: Centre hospitalier universitaire, 21000 Dijon, France.
authors.forename: A
authors.initials: A
authors.lastname: Bron
authors.affiliation: Groupe hospitalier Saint-Joseph, 75674 Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Lachkar
authors.affiliation: Centre ophtalmologique Kléber, 69006 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Sellem
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, 75005 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Renard
authors.affiliation: Centre hospitalier national d'ophtalmologie des Quinze-Vingts, 75012 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Nordmann
authors.affiliation: Centre hospitalier régional universitaire, 59000 Lille, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Rouland
authors.affiliation: Hôpital de la Croix-Rousse, Hospices civils de Lyon, 69004 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Denis
keywords: Benzalkonium chloride; Chlorure de benzalkonium; Collyres; Conservateurs; Dry eye; Eye drop; Glaucoma; Glaucome; Medications; Ocular surface; Preservative; Surface oculaire; Sécheresse oculaire; Tolerability; Tolérance; Toxicity; Toxicité; Traitement