title: Aminoacids as non-traditional plasticizers of maltodextrins fast-dissolving films.
abstract: This study explored the effect of aminoacids as non-traditional plasticizers of maltodextrins fast dissolving films. 5% w/w glycine and proline decreased the glass transition temperature (Tg) of maltodextrins from 102.6±2.0°C to 73.1±1.4°C and 76.1±0.7°C, respectively; meanwhile the binary mixture made with lysine had a Tg value of 83.6±2.2°C. At the same time, all aminoacids increased the ΔCp values. The shift of the thermal data were due to profound effect on the hydrogen bonding as evidenced by ATR-FTIR spectra since the OH stretching and scissoring bands decreased of about 15-26 cm(-1). A linear relationship was found (R(2)=0.9334) between HOH scissoring wavenumbers and Tg values. The addition of glycine and proline resulted effective in reducing the elastic modulus (about 50%) and tensile strength (about three times) and, therefore, can be used to increase the film ductility.
authors.affiliation: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71, 20133 Milan, Italy. Electronic address: francesca.selmin@unimi.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Selmin
authors.affiliation: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71, 20133 Milan, Italy. Electronic address: ilaria.franceschini@unimi.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Franceschini
authors.affiliation: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71, 20133 Milan, Italy. Electronic address: cupone@bouty.it.
authors.forename: Irma E
authors.initials: IE
authors.lastname: Cupone
authors.affiliation: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71, 20133 Milan, Italy. Electronic address: paola.minghetti@unimi.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Minghetti
authors.affiliation: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71, 20133 Milan, Italy. Electronic address: francesco.cilurzo@unimi.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cilurzo
mesh_terms: D002152:Calorimetry, Differential Scanning; D055119:Elastic Modulus; D005998:Glycine / Q000737:chemistry*; D006860:Hydrogen Bonding; D008239:Lysine / Q000737:chemistry*; D010968:Plasticizers / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D013818:Thermogravimetry
chemical_list: D010968:Plasticizers; D011134:Polysaccharides; C008315:maltodextrin; D011392:Proline; D008239:Lysine; D005998:Glycine
keywords: ATR-FTIR spectroscopy; DSC; Fast-dissolving films; Maltodextrins; Plasticization; Tensile properties