title: Accelerated orthodontic tooth movement: molecular mechanisms.
abstract: Accelerating orthodontic tooth movement can significantly reduce treatment duration and risks of side effects. The rate of orthodontic tooth movement is chiefly determined by the remodeling of tissues surrounding the roots; this in turn is under the control of molecular mechanisms regulating cellular behaviors in the alveolar bone and periodontal ligament. This review summarizes the current knowledge on the molecular mechanisms underlying accelerated orthodontic tooth movement, and the clinical and experimental methods that accelerate orthodontic tooth movement with possible molecular mechanisms. The review also shows directions for future studies to develop more clinically applicable methods to accelerate orthodontic tooth movement.
authors.affiliation: Assistant professor, Department of Orthodontics and Pediatric Dentistry, School of Dental Medicine, State University of New York, Stony Brook, NY.
authors.forename: Hechang
authors.initials: H
authors.lastname: Huang
authors.affiliation: Professor, Department of Periodontology, School of Dental Medicine, State University of New York, Stony Brook, NY.
authors.forename: Ray C
authors.initials: RC
authors.lastname: Williams
authors.affiliation: Professor and chair, Department of Orthodontics and Pediatric Dentistry, associate dean, Research and Faculty Development, School of Dental Medicine, State University of New York, Stony Brook, NY. Electronic address: Stephanos.Kyrkanides@stonybrookmedicine.edu.
authors.forename: Stephanos
authors.initials: S
authors.lastname: Kyrkanides
mesh_terms: D000539:Alveolar Process / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010011:Osteocytes / Q000502:physiology; D010513:Periodontal Ligament / Q000502:physiology; D014087:Tooth Movement Techniques / Q000379:methods*