title: Recent advances in research on Crimean-Congo hemorrhagic fever.
abstract: Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.
authors.affiliation: Department of Microbiology, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: annap@med.auth.gr.
authors.forename: Anna
authors.initials: A
authors.lastname: Papa
authors.affiliation: Swedish Institute for Communicable Disease Control, SE 171 82 Sweden; National Veterinary Institute, SE-756 51 Sweden; Dept for Clinical and Experimental Medicine, Linkopings University, SE-581 83 Sweden.
authors.forename: Ali
authors.initials: A
authors.lastname: Mirazimi
authors.affiliation: Karadeniz Technical University, Medical Faculty, Department of Infectious Diseases, Trabzon, Turkey.
authors.forename: Iftihar
authors.initials: I
authors.lastname: Köksal
authors.affiliation: Department of Animal Pathology, University of Zaragoza, Zaragoza, Spain.
authors.forename: Augustin
authors.initials: A
authors.lastname: Estrada-Pena
authors.affiliation: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, USA.
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D021821:Communicable Diseases, Emerging; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology / Q000472:pathogenicity*; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D013987:Ticks / Q000821:virology*; D014765:Viral Vaccines; D015047:Zoonoses
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines
keywords: Crimean-Congo hemorrhagic fever; Ecology; Epidemiology