title: Oocyte donation outcome after oncological treatment in cancer survivors.
abstract: OBJECTIVE
  To study reproductive outcome in patients cured of cancer who required oocyte donation (OD) owing to iatrogenic ovarian dysfunction.
  
  
  METHODS
  Multicenter, unmatched, retrospective cohorts study.
  
  
  METHODS
  Private, university-affiliated group of clinics.
  
  
  METHODS
  Women treated and cured of cancer (n = 142) who underwent 333 cycles of OD (exposed group) and women without a previous cancer diagnosis (n = 17,844) who underwent 29,778 cycles of OD (unexposed cohort) between January 2000 and January 2012.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Pregnancy, implantation, miscarriage, and ongoing pregnancy rates.
  
  
  RESULTS
  There were no differences in terms of pregnancy (55.7% vs. 54.7%), implantation (39.8% vs. 38.2%), miscarriage (29.5% vs. 26.9%), or delivery rates (39.3% vs. 39.9%) between the unexposed group and the patients previously diagnosed and cured of cancer, respectively. There was no correlation between OD outcome and cancer type.
  
  
  CONCLUSIONS
  Endometrial receptivity in women treated and cured of cancer was comparable to that of general patients without previous malignancies who had received OD, based on the largest series available in the literature.
authors.affiliation: IVI Vigo, Vigo, Spain. Electronic address: elkin.munoz@ivi.es.
authors.forename: Elkin
authors.initials: E
authors.lastname: Muñoz
authors.affiliation: IVI Vigo, Vigo, Spain.
authors.forename: Iria
authors.initials: I
authors.lastname: Fernandez
authors.affiliation: IVI Madrid, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Martinez
authors.affiliation: IVI Seville, Seville, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Tocino
authors.affiliation: IVI Vigo, Vigo, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Portela
authors.affiliation: Instituto Universitario IVI Valencia, Universidad de Valencia, Valencia, Spain; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.affiliation: IVI Madrid, Madrid, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: García-Velasco
authors.affiliation: Instituto Universitario IVI Valencia, Universidad de Valencia, Valencia, Spain.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Garrido
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D015984:Causality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D009369:Neoplasms / Q000453:epidemiology*; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D010049:Ovarian Diseases / Q000453:epidemiology* / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D017741:Survivors / Q000706:statistics & numerical data; D016896:Treatment Outcome
keywords: Assisted reproduction; cancer; chemotherapy; oocytes donation; radiotherapy