title: Structure-activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases.
abstract: In the present study, we designed and synthesised new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octane (DABCO) moieties with hydrophobic groups connected by different linkers. The structure and the RNA-cleavage activity relationships of this novel series of artificial ribonucleases (aRNases) were investigated.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia. Electronic address: kat7@ngs.ru.
authors.forename: E
authors.initials: E
authors.lastname: Burakova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Kovalev
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
authors.forename: M
authors.initials: M
authors.lastname: Zenkova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
authors.forename: V
authors.initials: V
authors.lastname: Vlassov
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
authors.forename: V
authors.initials: V
authors.lastname: Silnikov
mesh_terms: D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000071228:Polyelectrolytes; D012313:RNA / Q000378:metabolism*; D012260:Ribonucleases / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D010879:Piperazines; D011073:Polyamines; D000071228:Polyelectrolytes; D012313:RNA; D012260:Ribonucleases; C007306:triethylenediamine
keywords: Artificial ribonucleases; Lipophilicity; Phosphodiester bond cleavage; RNA