title: Current management and long-term outcomes following chorioamnionitis.
abstract: Chorioamnionitis is the process of active infection within the amniotic cavity that induces an inflammatory response. A wide variety of pathologic organisms can cause chorioamnionitis. Prompt diagnosis and timely treatment with broad-spectrum antibiotics can help avert the significant short-term and long-term consequences that may result. This review aims to summarize the up-to-date diagnosis criteria, treatment protocols, and long-term sequelae of missed diagnoses or poorly treated disease. It also calls for future studies that aim to better understand the mechanism of disease and to develop better detection and intervention methods to prevent the significant associated morbidity.
authors.affiliation: Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287, USA; Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA.
authors.forename: Clark T
authors.initials: CT
authors.lastname: Johnson
authors.affiliation: Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA; Department of Pediatrics, Johns Hopkins Medical Institutions, 1800 Orleans Street, Baltimore, MD 21287, USA; International Center for Maternal & Newborn Health, Johns Hopkins University, 605 North Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Farzin
authors.affiliation: Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287, USA; Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA; Department of Neurology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: iburd@jhmi.edu.
authors.forename: Irina
authors.initials: I
authors.lastname: Burd
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D036861:Delivery, Obstetric; D004334:Drug Administration Schedule; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Chorioamnionitis; Endometritis; Fetal infection; Fetal inflammation; Funisitis; Neonatal sepsis; Perinatal infection; Perinatal inflammation