title: Analgesic topical capsaicinoid therapy increases somatostatin-like immunoreactivity in the human plasma.
abstract: The aim of the present study was to evaluate the therapeutic potential of local capsaicinoid (EMSPOMA(®) cream) treatment on chronic low back pain in patients with degenerative spine diseases and to investigate the possible mechanism of action of the therapy. The qualitative and quantitative analyses of capsaicinoids in EMSPOMA(®) cream were performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In the clinical study 20 patients with degenerative spine diseases were involved in a self-controlled examination. During the 21 day therapy they received 30 min daily treatment with capsaicinoid (EMSPOMA(®)) cream to the lumbar region of the back. The pain (VASs, Oswestry Disability Index) and the mobility of the lumbar region of the spine (Schober's, Domján's L and R test) were detected at baseline and at the end of the 1st, 2nd and 3rd weeks. The plasma level of somatostatin-like immunoreactivity (SST-LI) was measured by radioimmunoassay (RIA) before and after the treatment on the first and the last day of the therapy. Nonivamide (0.01%) was identified as the only capsaicinoid molecule in the cream. In the clinical study the 21 day local nonivamide treatment reduced the pain sensation. Oswestry Disability Index decreased from 39 ± 3.9% to 32.5 ± 4.4%. VASs showed 37.29%-59.51% improvement. In the plasma level of SST-LI threefold elevation was observed after the first nonivamide treatment. We conclude that nonivamide treatment exerts analgesic action in chronic low back pain and causes the release of the antinociceptive and anti-inflammatory neuropeptide somatostatin which may play pivotal role in the pain-relieving effect.
authors.affiliation: Zsigmondy Vilmos Harkány Medicinal Spa Hospital, 1 Zsigmondy Street, Harkány 7815, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Horváth
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Boros
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary.
authors.forename: Teréz
authors.initials: T
authors.lastname: Bagoly
authors.affiliation: MTA-PTE Molecular Interactions in Separation Science Research Group, 12 Szigeti Street, Pécs 7624, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary.
authors.forename: Viktor
authors.initials: V
authors.lastname: Sándor
authors.affiliation: Department of Bioanalysis, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Kilár
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Kemény
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Helyes
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Szolcsányi
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary. Electronic address: erika.pinter@aok.pte.hu.
authors.forename: Erika
authors.initials: E
authors.lastname: Pintér
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D002211:Capsaicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D013004:Somatostatin / Q000097:blood*; D013118:Spinal Cord Diseases / Q000150:complications
chemical_list: D000700:Analgesics; D013004:Somatostatin; D002211:Capsaicin; C040937:nonivamide
keywords: Analgesic effect; Capsaicinoid; Chronic low back pain; Mechanism of action; Nonivamide; Somatostatin; TRPV1 receptor