title: Aging in the canine and feline brain.
abstract: Aging dogs and cats show neurodegenerative features that are similar to human aging and Alzheimer disease. Neuropathologic changes with age may be linked to signs of cognitive dysfunction both in the laboratory and in a clinic setting. Less is known about cat brain aging and cognition and this represents an area for further study. Neurodegenerative diseases such as lysosomal storage diseases in dogs and cats also show similar features of human aging, suggesting some common underlying pathogenic mechanisms and also suggesting pathways that can be modified to promote healthy brain aging.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Section of Neurology & Neurosurgery, Department of Clinical Studies - Philadelphia, 3900 Delancey Street, Philadelphia, PA 19104, USA.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Vite
authors.affiliation: Department of Pharmacology & Nutritional Sciences, Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, 203 Sanders Brown Building, Lexington, KY 40515, USA. Electronic address: elizabeth.head@uky.edu.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Head
mesh_terms: D000375:Aging; D000818:Animals; D001927:Brain Diseases / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs
keywords: Cat; Cognitive dysfunction; Dog; Neuron loss; Tau; β-Amyloid