title: Influence of glucose-lowering rate on CKMB and myoglobin serum levels in type-2 diabetes patients with coronary heart disease.
abstract: OBJECTIVE
  To analyze the level of creatine kinase isoenzyme (CKMB), myoglobin, to explore the influence of different glucose-lowering rate on cardiac enzyme in type 2 diabetes mellitus patients with coronary heart disease (T2DMC), to search for the rational glucose-lowering rate.
  
  
  METHODS
  A total number of 293 type 2 diabetic patients who were hospitalized in the First Affiliated Hospital of Harbin Medical University from May 2008 to December 2009 were recruited. Two groups were divided according to the coronary angiography. 142 subjects of type 2 diabetes mellitus (T2DM) and 151 subjects of T2DMC received intensive glucose therapy. After CKMB and myoglobin being measured, variation and correlation factors were evaluated.
  
  
  RESULTS
  In T2DM group, the level of CKMB was significantly lower at follow-up than that before intensive therapy. Then, we got four subgroups according to the glucose-lowering rate. In T2DM group, when the fasting or postprandial glucose-lowering rate was no more than 6 mmolL(-1)d(-1), the level of CKMB and myoglobin were significantly lower than that before intensive therapy (P<0.05). When the fasting glucose-lowering rate is faster than 6 mmolL(-1)d(-1), the level of CKMB is significantly higher after intensive therapy than that before glucose-lowering (P<0.05). In T2DMC group, when the fasting or postprandial glucose-lowering rate was not more than 4 mmolL(-1)d(-1), the level of CKMB and myoglobin was significantly lower than that before intensive therapy (P<0.05, P<0.01). When the fasting glucose-lowering rate was faster than 4 mmolL(-1)d(-1), the level of CKMB and myoglobin was significantly higher at follow-up than that before intensive therapy (P<0.05). Before intensive therapy, high density lipoprotein cholesterol (HDL-C) has a negative linear regression relationship with CKMB (P<0.01). Low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) and glycosylated hemoglobin A1c (HbA1c) have a positive linear regression relationship with CKMB (P<0.05). HDL-C has a negative linear regression relationship with myoglobin (P<0.01). LDL-C and TG have a positive linear regression relationship with myoglobin (P<0.01).
  
  
  CONCLUSIONS
  T2DM patients, no matter with CHD or not, all have a rational fasting glucose-lowering rate; the fasting glucose-lowering rate is more susceptible to myocardial damage anticipation than the postprandial glucose-lowering rate.
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Sun
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China. Electronic address: hydwwh@163.com.
authors.forename: Weihua
authors.initials: W
authors.lastname: Wu
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Liu
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ma
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Mingli
authors.initials: M
authors.lastname: Wang
authors.affiliation: The First Clinical Medical School, Harbin Medical University, PR China.
authors.forename: Jiajing
authors.initials: J
authors.lastname: Miao
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D052279:Creatine Kinase, MB Form; D006442:Glycated Hemoglobin; D009211:Myoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human
keywords: Coronary heart disease; Creatine kinase isoenzyme; Glucose-lowering rate; Myoglobin; Type 2 diabetes mellitus