title: Cortical thinning in type 2 diabetes mellitus and recovering effects of insulin therapy.
abstract: The purpose of this study was to explore the brain structural changes in type 2 diabetes and the effect of insulin on the brain using a surface-based cortical thickness analysis. High-resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI were obtained from 11 patients with type 2 diabetes before and after insulin therapy. The cortical thickness over the entire brain was calculated, and cross-sectional and longitudinal surface-based cortical thickness analyses were also performed. Regional cortical thinning was demonstrated in the middle temporal gyrus, posterior cingulate gyrus, precuneus, right lateral occipital gyrus and entorhinal cortex bilaterally for patients with type 2 diabetes mellitus compared with normal controls. Cortical thickening was seen in the middle temporal gyrus, entorhinal cortex and left inferior temporal gyrus bilaterally after patients underwent 1 year of insulin therapy. These findings suggest that insulin therapy may have recovering effects on the brain cortex in type 2 diabetes mellitus. The precise mechanism should be investigated further.
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Zhiye
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Chinese PLA 89 Hospital, Weifang, Shandong, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lou
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. Electronic address: cjr.malin@vip.163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Brain; Cerebral cortex; Insulin; MRI; Type 2 diabetes mellitus