title: Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial.
abstract: OBJECTIVE
  The purpose of the study was to evaluate the clinical effects of the Shenzhu Tiaopi granule (SZTP) combined with a lifestyle intervention in patients with impaired glucose tolerance (IGT), who also had a spleen deficiency and damp overabundance syndrome (SDDOS).
  
  
  METHODS
  After a one-month washout period, a total of 514 patients were randomly assigned to the control (lifestyle intervention) and experimental (SZTP plus lifestyle intervention) groups, with 257 patients in each group. Patients in the control group received the lifestyle intervention (diet and exercise) for 12 months, while the patients in the experimental group were treated with SZTP plus the lifestyle intervention for 12 months. The Traditional Chinese Medicinal (TCM) symptom scores were observed in each group before and after treatment; the conversion rates from IGT to diabetes mellitus (DM) were also measured.
  
  
  RESULTS
  Following 12 months of treatment, the conversion rate from IGT to DM in the experimental group was significantly lower than in the control group (8.52% vs. 15.28%, P<0.05). A significantly higher number of patients with IGT reverted to normal blood glucose levels in the experimental group than in the control group (42.15% vs. 32.87%, P<0.05). In addition, after following the treatment for 12 months, the TCM symptoms of patients in the experimental group were markedly alleviated, as compared to the control group (P<0.01).
  
  
  CONCLUSIONS
  The combination of SZTP and lifestyle intervention showed a reduction in the conversion from IGT to DM, and an increase in the conversion from IGT to normal blood glucose levels.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China; Institute of Chinese Medicine Prevention and Therapy Diabetes Mellitus, Anhui Academy of Chinese Medicine, Hefei 230031, Anhui Province, China. Electronic address: fangzhaohui1111@163.com.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Fang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China; Institute of Chinese Medicine Prevention and Therapy Diabetes Mellitus, Anhui Academy of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Guobing
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Yiqiong
authors.initials: Y
authors.lastname: Shu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Yingqun
authors.initials: Y
authors.lastname: Ni
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Ruimin
authors.initials: R
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Shangyu City Hospital of Chinese Medicine, Shangyu 312300, Zhejiang Province, China.
authors.forename: Senhua
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, the Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Wuhu City Hospital of Chinese Medicine, Wuhu 241000, Anhui Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Hanpeng
authors.initials: H
authors.lastname: Ling
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Institute of Chinese Medicine Prevention and Therapy Diabetes Mellitus, Anhui Academy of Chinese Medicine, Hefei 230031, Anhui Province, China; The Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005221:Fatigue / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D008055:Lipids
keywords: Impaired glucose tolerance (IGT); Lifestyle; Shenzhu Tiaopi granule (SZTP); Spleen deficiency and damp overabundance syndrome (SDDOS)