title: A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines.
abstract: This review provides an outlook of the medical applications of immunomodulatory compounds taken from Pleurotus and proposes this fungus as a convenient host for the development of innovative vaccines. Although some fungal species, such as Saccharomyces and Pichia, occupy a relevant position in the biopharmaceutical field, these systems are essentially limited to the production of conventional expensive vaccines. Formulations made with minimally processed biomass constitute the ideal approach for developing low cost vaccines, which are urgently needed by low-income populations. The use of edible fungi has not been explored for the production and delivery of low cost vaccines, despite these organisms' attractive features. These include the fact that edible biomass can be produced at low costs in a short period of time, its high biosynthetic capacity, its production of immunomodulatory compounds, and the availability of genetic transformation methods. Perspectives associated to this biotechnological application are identified and discussed.
authors.affiliation: Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, SLP, 78210, Mexico.
authors.forename: Ana S
authors.initials: AS
authors.lastname: Pérez-Martínez
authors.affiliation: Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, SLP, 78210, Mexico.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Acevedo-Padilla
authors.affiliation: Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Tepetitla de Lardizábal, Tlaxcala, 90700, Mexico.
authors.forename: Martha
authors.initials: M
authors.lastname: Bibbins-Martínez
authors.affiliation: Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, SLP, 78210, Mexico.
authors.forename: Jenifer
authors.initials: J
authors.lastname: Galván-Alonso
authors.affiliation: Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, SLP, 78210, Mexico. Electronic address: rosales.s@fcq.uaslp.mx.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
mesh_terms: D001709:Biotechnology / Q000379:methods*; D006801:Humans; D020076:Pleurotus / Q000235:genetics / Q000378:metabolism*; D013678:Technology, Pharmaceutical / Q000379:methods*; D022462:Vaccines, Edible / Q000235:genetics / Q000378:metabolism*; D022223:Vaccines, Subunit / Q000235:genetics / Q000378:metabolism*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000378:metabolism*
chemical_list: D022462:Vaccines, Edible; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
keywords: Adjuvant; Fungi; Glucan; Mushrooms; Oral subunit vaccine; Production cost