title: [Infusion of vasoactive drugs at low flow rate: effects of the syringe switch and syringe volume (experimental study)].
abstract: OBJECTIVE
  The flow rate of intravenous administration of vasoactive agents should be steady in order to prevent changes in hemodynamics. In the newborns, because the flow rate is often lower than 1mL/h, it is difficult to switch of the syringe. The aim of our study was to compare the variations of concentration of active substance delivered after a manual or an automatic switch off the syringe with three different volumes (10mL, 20mL and 50mL).
  
  
  METHODS
  Glucose solution (10g/L) was used to simulate the administered substance. Saline was administered in "Y" simultaneously with the glucose solution through a catheter. The infused substance was collected at the tip of the catheter. The glucose concentration was measured at 15min-interval for 3hours.
  
  
  RESULTS
  The manual switch of the syringe was associated with a significant alteration of the flow rate, lasting more than 15min. In contrast, the automatic switch of syringes was associated with no change of the flow rate, especially with small-volume syringes (10mL).
  
  
  CONCLUSIONS
  In newborns, in order to prevent the change in flow rate of drugs after a switch of syringes, our results suggest the use of syringe-pump with built-in automatic switch and small-volume syringes.
authors.affiliation: Pôle Femme-Mère-Nouveau-Né, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, rue Eugène-Aviné, 59037 Lille cedex 1, France; EA 4489, environnement périnatal et santé, faculté de médecine, université Lille II, 42, rue Paul-Duez, 59800 Lille, France. Electronic address: thameur.rakza@chru-lille.fr.
authors.forename: T
authors.initials: T
authors.lastname: Rakza
authors.affiliation: Pôle Femme-Mère-Nouveau-Né, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, rue Eugène-Aviné, 59037 Lille cedex 1, France.
authors.forename: A
authors.initials: A
authors.lastname: Fily
authors.affiliation: Pôle Femme-Mère-Nouveau-Né, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, rue Eugène-Aviné, 59037 Lille cedex 1, France.
authors.forename: S
authors.initials: S
authors.lastname: Mur
authors.affiliation: Pôle Femme-Mère-Nouveau-Né, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, rue Eugène-Aviné, 59037 Lille cedex 1, France.
authors.forename: T
authors.initials: T
authors.lastname: Pennaforte
authors.affiliation: Pôle Femme-Mère-Nouveau-Né, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, rue Eugène-Aviné, 59037 Lille cedex 1, France; EA 4489, environnement périnatal et santé, faculté de médecine, université Lille II, 42, rue Paul-Duez, 59800 Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Storme
mesh_terms: D001331:Automation; D057785:Catheters; D004867:Equipment Design; D005260:Female; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D013594:Syringes; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
chemical_list: D005950:Glucose Solution, Hypertonic; D014662:Vasoconstrictor Agents
keywords: Automatic switch; Enfant prématuré; Médicament vasoactif; Premature baby; Relais automatisés; Vasoactive agents