title: The proteasome and the degradation of oxidized proteins: Part II - protein oxidation and proteasomal degradation.
abstract: Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted.
authors.affiliation: Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Jung
authors.affiliation: Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Höhn
authors.affiliation: Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany. Electronic address: tilman.grune@uni-jena.de.
authors.forename: Tilman
authors.initials: T
authors.lastname: Grune
mesh_terms: D000818:Animals; D006801:Humans; D010084:Oxidation-Reduction; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D059748:Proteolysis
chemical_list: D046988:Proteasome Endopeptidase Complex
keywords: 20S Proteasome; Immunoproteasome; Protein aggregates; Protein oxidation