title: Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus).
abstract: Selective Serotonin Re-uptake Inhibitors (SSRI) are mood-altering, psychotropic drugs commonly used in the treatment of depression and other psychological illnesses. Many of them are poorly degraded in sewage treatment plants and enter the environment unaltered. In laboratory studies, they have been demonstrated to affect a wide range of behaviours in aquatic organisms. In this study we investigated the effect of a three-week exposure to 0.15 and 1.5 μg/l of the SSRI citalopram dissolved in the ambient water on the feeding behaviour in three-spine stickleback (Gasterosteus aculeatus). Feeding, measured as the number of attacks performed on a piece of frozen bloodworms during a 10-min period, was reduced by 30-40% in fish exposed to both 0.15 and 1.5 μg/l citalopram. The effects of the environmentally relevant concentration 0.15 μg/l on feeding, an important fitness characteristic, suggests that the ecological significance of environmental SSRI exposure may be pronounced.
authors.affiliation: Department of Natural Sciences, Environment and Technology, Södertörn University, SE-14189 Huddinge, Sweden. Electronic address: martin.kellner@sh.se.
authors.forename: M
authors.initials: M
authors.lastname: Kellner
authors.affiliation: Department of Natural Sciences, Environment and Technology, Södertörn University, SE-14189 Huddinge, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Porseryd
authors.affiliation: Department of Natural Sciences, Environment and Technology, Södertörn University, SE-14189 Huddinge, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Porsch-Hällström
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: S H
authors.initials: SH
authors.lastname: Hansen
authors.affiliation: Department of Natural Sciences, Environment and Technology, Södertörn University, SE-14189 Huddinge, Sweden.
authors.forename: K H
authors.initials: KH
authors.lastname: Olsén
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015283:Citalopram / Q000633:toxicity*; D004781:Environmental Exposure; D005247:Feeding Behavior / Q000187:drug effects*; D023701:Smegmamorpha / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D015283:Citalopram
keywords: Antidepressant; Citalopram; Feeding; SSRI; Serotonin; Three-spine stickleback