title: Herpes simplex virus infection during pregnancy.
abstract: Genital herpes in pregnancy continues to cause significant maternal morbidity, with an increasing number of infections being due to oral-labial transmission of herpes simplex virus (HSV)-1. Near delivery, primary infections with HSV-1 or HSV-2 carry the highest risk of neonatal herpes infection, which is a rare but potentially devastating disease for otherwise healthy newborns. Prevention efforts have been limited by lack of an effective intervention for preventing primary infections and the unclear role of routine serologic testing.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA. Electronic address: alyssabs@uw.edu.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Stephenson-Famy
authors.affiliation: Division of Women's Health, Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA; Department of Gynecology, VA Puget Sound Medical Center, 1600 South Columbian Way, Seattle, WA 98108, USA.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Gardella
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents; D002585:Cesarean Section; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009749:Nutrition Surveys; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control*; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014481:United States / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents
keywords: Antiviral therapy; Genital herpes; Neonatal herpes; Pregnancy; Prevention; Serologic screening