title: Comparison of spot urine protein creatinine ratio with 24 hour urine protein for estimation of proteinuria.
abstract: The objective of our study was to evaluate and standardise the method of spot (random) urine protein creatinine ratio (UP/C) for estimation of proteinuria. The study contained 241 study participants in a tertiary care hospital inclusive of 208 cases and 33 normal volunteers. The 24 hour urine protein estimation was done on 24 hour urine samples and UP/C ratio was calculated on random urine samples. UP/C ratio and 24 hour urine protein estimation had strong correlation with r = 0.9 and p < 0.05 on Pearson's correlation analysis. Receiver operating characteristic analysis showed random UP/C ratio of 0.1171 reliably predicted 24 hour urine total protein equivalent of > 150 mg/24 hrs with sensitivity 100%, specificity 98.1%, positive likelihood ratio 53.5, and negative likelihood ratio 0. UP/C ratio of 3.2 reliably predicted nephrotic range proteinuria at 24 hour urine protein equivalent of > 3.5 g/24 hrs with sensitivity 80%, specificity 100%, positive likelihood ratio 154.4, and negative likelihood ratio 0.2. We conclude that spot/random UP/C ratio is a reliable, simple test to be introduced and adopted in routine practice for monitoring of macro proteinuria.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Patil
authors.forename: Vinaya
authors.initials: V
authors.lastname: Shah
authors.forename: Bipin
authors.initials: B
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine*; D012016:Reference Values; D012307:Risk Factors; D062606:Tertiary Care Centers; D016482:Urinalysis / Q000379:methods / Q000592:standards; D055815:Young Adult
chemical_list: D003404:Creatinine