title: Treg/Th17 balance in stable CAD patients with different stages of coronary atherosclerosis.
abstract: Objective. Immune processes play a significant role in atherosclerosis plaque progression. Regulatory T cells and T helpers 17 were shown to possess anti- and pro-atherogenic activity, respectively. We aimed to investigate the balance of circulating Treg and Th17 in stable angina patients with different stages of coronary atherosclerosis. Methods. Treg, Th17 and Th1 cell frequencies were studied in 117 patients via direct immunofluorescence staining and flow cytometry. Group 1 had intact coronary arteries. Group 2 and Group 3 had undergone previous coronary stenting; in Group 2 no coronary atherosclerosis progression was found, in Group 3 patients had disease progression in non-invaded coronary arteries. Group 4 had severe coronary atherosclerosis. Results. The frequencies of CD4+CD25highCD127low, CD4+foxp3+, and CD4+IL10 + T cells were decreased, and CD4+IL17 + T cells frequencies were increased in group 4 vs. 1. Treg/Th17 ratios were declined in groups 3 and 4 vs. groups 1 and 2. IL-10 level was lower while hsCRP and sCD25 levels were higher in group 4 vs. 1. Conclusion. We assume that the imbalance in pro- and anti-inflammatory/atherogenic lymphocyte subpopulations is associated with atherosclerosis progression.
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: potehina@gmail.com.
authors.forename: Alexandra V
authors.initials: AV
authors.lastname: Potekhina
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: iamfrommsu@yandex.ru.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Pylaeva
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: semaver@yandex.ru.
authors.forename: Sergey
authors.initials: S
authors.lastname: Provatorov
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: nruleva@cardio.ru.
authors.forename: Natalya
authors.initials: N
authors.lastname: Ruleva
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: massenko@mail.ru.
authors.forename: Valery
authors.initials: V
authors.lastname: Masenko
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: albumin1080@gmail.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Noeva
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: tlkrasnikova@gmail.com.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Krasnikova
authors.affiliation: Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: arefieva@cardio.ru.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Arefieva
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology; D003324:Coronary Artery Disease / Q000276:immunology* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation / Q000473:pathology; D016753:Interleukin-10 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D053699:Interleukin-7 Receptor alpha Subunit / Q000378:metabolism; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*; D058504:Th17 Cells / Q000166:cytology*
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007166:Immunosuppressive Agents; D020381:Interleukin-17; D053645:Interleukin-2 Receptor alpha Subunit; D053699:Interleukin-7 Receptor alpha Subunit; D016753:Interleukin-10
keywords: Coronary artery disease; Regulatory T cells; T helpers 17