title: Acute and subacute (28 days) oral toxicity assessment of the oil  extracted from Acrocomia aculeata pulp in rats.
abstract: Acrocomia aculeata, popularly known as “bocaiúva”, is a species used for nutritional purposes and for the treatment of various diseases, as it has, among other things, high levels of antioxidant compounds. This study aimed to assess the toxicological profile of A. aculeata, through acute and subacute toxicity tests. Male and female rats (Wistar) received by gavage 2000 mg/kg of oil extracted from the pulp of A. aculeata (OPAC) for the acute toxicity test and 125, 250, 500 or 1000 mg/kg of OPAC for subacute toxicity test. In the acute toxicity study no mortality or behavioral changes were observed in rats treated with 2000 mg/kg, indicating that the LD50 is higher than this dose. In the subacute toxicity test, the tested doses produced no significant changes in hematological, biochemical or histopathological parameters in the animals exposed. These results demonstrate the absence of acute and subacute toxicity after oral exposure to A. aculeata oil in rats. However, further studies in animals and in humans are needed in order to have sufficient safety evidence for its use in humans.
authors.affiliation: School of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
authors.forename: Giseli Karenina
authors.initials: GK
authors.lastname: Traesel
authors.forename: Juliane Coelho
authors.initials: JC
authors.lastname: de Souza
authors.forename: Aline Lima
authors.initials: AL
authors.lastname: de Barros
authors.forename: Marcos Alexandre
authors.initials: MA
authors.lastname: Souza
authors.forename: Wanderley Onofre
authors.initials: WO
authors.lastname: Schmitz
authors.forename: Rozanna Marques
authors.initials: RM
authors.lastname: Muzzi
authors.forename: Silvia Aparecida
authors.initials: SA
authors.lastname: Oesterreich
authors.forename: Arielle Cristina
authors.initials: AC
authors.lastname: Arena
mesh_terms: D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D001772:Blood Cell Count; D005229:Fatty Acids, Monounsaturated / Q000032:analysis; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
chemical_list: D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils