title: [KHSV/EBV associated germinotropic lymphoproliferative disorder: a rare entity, case report and review of the literature].
abstract: We report a case of KSHV/EBV associated germinotropic lymphoproliferative disorder (LPG) in a 49-year-old African patient, without immunosuppression. LPG is a rare entity arising in immunocompetent patients in opposition to other lymphoproliferative disorders associated to Kaposi sarcoma-associated herpes virus (KSHV). The disease presents itself as localized lymphadenopathy with an infiltration of germinal centers by plasmablastic cells coinfected by KSHV and EBV (Epstein-Barr Virus). After treatment, the outcome is favorable. Differential diagnosis in our case, due to the presence of clusters of Hodgkin-like cells in the mantle zone, included lymphocyte rich classic Hodgkin lymphoma (LHCRL) and nodular lymphocyte predominant Hodgkin lymphoma (LHNPL). Finally, we highlight the differential diagnostic criteria of KSHV lymphoproliferative diseases.
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU de Poitiers, rue de la Milétrie, 86000 Poitiers, France. Electronic address: michael.taris@gmail.com.
authors.forename: Michaël
authors.initials: M
authors.lastname: Taris
authors.affiliation: Service de pathologie, hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33600 Pessac, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: de Mascarel
authors.affiliation: Service de pathologie, centre hospitalier de La Rochelle, rue du Docteur-Schweitzer, 17000 La Rochelle, France.
authors.forename: Mercédès
authors.initials: M
authors.lastname: Riols
authors.affiliation: Service d'oncologie médicale, centre hospitalier de La Rochelle, rue du Docteur-Schweitzer, 17000 La Rochelle, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Delwail
authors.affiliation: Service d'hématologie, hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33600 Pessac, France.
authors.forename: Noël
authors.initials: N
authors.lastname: Milpied
authors.affiliation: Service de biologie des tumeurs, hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33600 Pessac, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
authors.affiliation: Service de pathologie, hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33600 Pessac, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Parrens
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D005260:Female; D018858:Germinal Center / Q000473:pathology; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008198:Lymph Nodes / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000473:pathology / Q000628:therapy / Q000821:virology*; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology; D012074:Remission Induction; D012514:Sarcoma, Kaposi / Q000473:pathology*
keywords: Castleman; EBV; Germinotropic lymphoproliferative disorder; HHV8; KSHV; Lymphoma; Lymphome; Lymphoprolifération germinotrope