title: Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.
abstract: Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Hima B
authors.initials: HB
authors.lastname: Avatapalle
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Mars S
authors.initials: MS
authors.lastname: Skae
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Raja
authors.initials: R
authors.lastname: Padidela
authors.affiliation: Department of Pediatric Histopathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Melanie
authors.initials: M
authors.lastname: Newbould
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Rigby
authors.affiliation: Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Flanagan
authors.affiliation: Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
authors.forename: Sian
authors.initials: S
authors.lastname: Ellard
authors.affiliation: Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Rahier
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; Manchester Academic Health Science Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Peter E
authors.initials: PE
authors.lastname: Clayton
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Dunne
authors.affiliation: Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Indraneel
authors.initials: I
authors.lastname: Banerjee
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom. Electronic address: karen.e.cosgrove@manchester.ac.uk.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Cosgrove
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002675:Child, Preschool; D044903:Congenital Hyperinsulinism / Q000097:blood* / Q000235:genetics; D006801:Humans; D054795:Incretins / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D054086:KATP Channels / Q000235:genetics*; D009154:Mutation; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D054795:Incretins; D054086:KATP Channels