title: Structural basis of cell apoptosis and necrosis in TNFR signaling.
abstract: The tumor necrosis factor receptors (TNFRs) play essential roles in innate and adaptive immunity. Depending on conditions, TNFR induces multiple cell fates including cell survival, cell apoptosis, and cell programmed necrosis. Here, we review recent progress in structural studies of the TNFR signaling pathway. The structural basis for the high order signal complexes, including the DISC, ripoptosome, necrosome, and RIP3/MLKL complex, may provide novel insights for understanding the biophysical principles of cell signaling cascades.
authors.affiliation: State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, 200438, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Shaoning
authors.initials: S
authors.lastname: Yu
authors.forename: Chaoneng
authors.initials: C
authors.lastname: Ji
authors.forename: Jixi
authors.initials: J
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D006801:Humans; D008958:Models, Molecular; D009336:Necrosis; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D053422:Receptor-Interacting Protein Serine-Threonine Kinases