title: The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome.
abstract: OBJECTIVE
  Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain.
  
  
  METHODS
  The study included 190 patients with an initial diagnosis of acute coronary syndrome in the emergency department. Based on a definitive diagnosis, these patients were classified into 3 groups: ST-elevation myocardial infarction (STEMI), NSTE-ACS, and NCCP.
  
  
  RESULTS
  Plasma SCUBE1 levels were significantly higher in the STEMI group when compared with those of the other groups (P < .05). They were also significantly higher in the NSTE-ACS group when compared with those of the NCCP group (P < .01). Troponin I, creatinine kinase, and creatinine kinase MB levels were significantly different in the NSTE-ACS group when compared with those of the NCCP group (P < .05).
  
  
  CONCLUSIONS
  High rates of SCUBE1 were found both in the STEMI and NSTE-ACS patients. Furthermore, in the study group, SCUBE1 was an adequate marker for distinguishing NSTE-ACS from NCCP.
authors.affiliation: Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: ertansnmz@gmail.com.
authors.forename: Ertan
authors.initials: E
authors.lastname: Sonmez
authors.affiliation: Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: drturkdogan@gmail.com.
authors.forename: Kenan Ahmet
authors.initials: KA
authors.lastname: Turkdogan
authors.affiliation: Isparta State Hospital, Department of Emergency Medicine, Isparta, Turkey. Electronic address: drmustafa1979@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.affiliation: Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: ccivelek@msn.com.
authors.forename: Cemil
authors.initials: C
authors.lastname: Civelek
authors.affiliation: Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: cahityilmaz870@hotmail.com.
authors.forename: Cahit
authors.initials: C
authors.lastname: Yilmaz
authors.affiliation: Bezmialem Vakıf University, Department of Emergency Medicine, İstanbul, Turkey. Electronic address: omerfaruk2005@yahoo.com.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Ozer
authors.affiliation: Dişkapi Yildirim Beyazit Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey. Electronic address: acildrumut@yahoo.com.
authors.forename: Umut Yücel
authors.initials: UY
authors.lastname: Çavuş
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D055395:Bone Morphogenetic Protein 1 / Q000097:blood*; D002637:Chest Pain / Q000097:blood / Q000175:diagnosis*; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D004815:Epidermal Growth Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D010865:Pilot Projects; D021382:Protein Sorting Signals; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood
chemical_list: D015415:Biomarkers; D021382:Protein Sorting Signals; D014336:Troponin; D004815:Epidermal Growth Factor; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; C525705:BMP1 protein, human; D055395:Bone Morphogenetic Protein 1