title: Electrocatalysis in DNA Sensors.
abstract: Electrocatalysis is often thought of solely in the inorganic realm, most often applied to energy conversion in fuel cells. However, the ever-growing field of bioelectrocatalysis has made great strides in advancing technology for both biofuel cells as well as biological detection platforms. Within the context of bioelectrocatalytic detection systems, DNA-based platforms are especially prevalent. One subset of these platforms, the one we have developed, takes advantage of the inherent charge transport properties of DNA. Electrocatalysis coupled with DNA-mediated charge transport has enabled specific and sensitive detection of lesions, mismatches and DNA-binding proteins. Even greater signal amplification from these platforms is now being achieved through the incorporation of a secondary electrode to the platform both for patterning DNA arrays and for detection. Here, we describe the evolution of this new DNA sensor technology.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125.
authors.forename: Ariel
authors.initials: A
authors.lastname: Furst
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hill
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Barton