title: Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.
abstract: Genetic association studies of the cytokine interleukin-10 (IL-10) and sepsis have provided inconsistent results. This work attempts to further quantitatively assess the association of three widely evaluated polymorphisms of IL-10 (-592C/A, -819C/T, -1082A/G) with sepsis susceptibility through a meta-analysis. A search of Pubmed, Web of Science and EMBASE databases was performed. Overall, the three polymorphisms have no strong association with sepsis risk. Subgroup analysis by ethnicity showed there was association between sepsis susceptibility with -592C/A in Caucasians (A vs. C: OR 0·78, 95% CI 0·62-1·00, P = 0·05; AA + CA vs. CC: OR 0·75, 95% CI 0·56-1·00, P = 0·05), and with -1082A/G in Asians (G vs. A: OR 1·41, 95% CI 1·04-1·91, P = 0·03; GG + AG vs. AA: OR 2·11, 95% CI 1·07-4·16, P = 0·03). This meta-analysis suggests that -592C/A and -1082A/G polymorphisms are associated with sepsis susceptibility in Caucasian, and Asian populations, respectively.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: W
authors.initials: W
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: A Q
authors.initials: AQ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: C L
authors.initials: CL
authors.lastname: Yue
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: J W
authors.initials: JW
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: W
authors.initials: W
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.
authors.forename: J X
authors.initials: JX
authors.lastname: Jiang
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018805:Sepsis / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10