title: An outlook review: mechanochromic materials and their potential for biological and healthcare applications.
abstract: Macroscopic mechanical perturbations have been observed to result in optical changes for certain compounds and composite materials. This phenomenon could originate from chemical and physical changes across various length scales, from the rearrangement of chemical bonds to alteration of molecular domains on the order of several hundred nanometers. This review classifies the mechanisms and surveys of how each class of mechanochromic materials has been, and can potentially be applied in biological and healthcare innovations. The study of cellular and molecular responses to mechanical forces in biological systems is an emerging field; there is potential in applying mechanochromic principles and material systems for probing biological systems. On the other hand, application of mechanochromic materials for medical and healthcare consumer products has been described in a wide variety of concepts and inventions. It is hopeful that further understanding of mechanochromism and material innovations would initiate concrete, impactful studies in biological systems soon.
authors.affiliation: Institute of Material Science and Engineering, 3 Research Link, 117602, Singapore. Electronic address: jiangy@imre.a-star.edu.sg.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D001578:Benzopyrans / Q000737:chemistry; D015374:Biosensing Techniques; D004396:Coloring Agents / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D055595:Mechanical Phenomena; D009574:Nitro Compounds / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism; D013473:Sunscreening Agents / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D004396:Coloring Agents; D005782:Gels; D007211:Indoles; D009574:Nitro Compounds; D011108:Polymers; D013473:Sunscreening Agents; C088184:spiropyran
keywords: Biological applications; Healthcare; Luminescence; Mechanochromism; Photonic gel; Polymer