title: ADXS-HPV: a therapeutic Listeria vaccination targeting cervical cancers expressing the HPV E7 antigen.
abstract: Listeria monocytogenes is a bacterium that can be genetically modified to express fusion proteins with antigens specific to certain cancer models. This technology has been harnessed to develop ADXS11-001, a vaccine that aims to elicit an immune response against human papillomavirus (HPV) oncoprotein E7.  Pre-clinical studies assessing the efficacy of recombinant Listeria vaccination targeting this same oncoprotein have consistently demonstrated successful reduction of in vivo tumor burden among animal cancer models. Several clinical trials are underway to assess the efficacy of ADXS11-001 in eliciting both immune and clinical responses against HPV-related human cervical, oropharyngeal and anal cancers.
authors.affiliation: a Department of Obstetrics and Gynecology ; Hospital of the University of Pennsylvania ; Philadelphia , PA USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Cory
authors.forename: Christina
authors.initials: C
authors.lastname: Chu
mesh_terms: D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D001005:Anus Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008089:Listeria monocytogenes / Q000235:genetics / Q000276:immunology*; D009959:Oropharyngeal Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D027383:Papillomaviridae / Q000276:immunology; D050725:Papillomavirus E7 Proteins / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology / Q000517:prevention & control; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D050725:Papillomavirus E7 Proteins; D011993:Recombinant Fusion Proteins; C059731:oncogene protein E7, Human papillomavirus type 16
keywords: ADXS11-001; FDA, Food and Drug Administration; GOG, Gynecologic Oncology Group; HPV, human papillomavirus; LLO, listeriolysin O; Listeria monocytogenes; Lm, Listeria monocytogenes; MHC, major histocompatibility complex; OPSCC, oropharyngeal cancer; PLC, phospholipase C; VLP, virus like protein; cervical cancer; human papillomavirus; immunotherapy