title: [Effect of the incubation medium pH on damage to macrophages plasma membranes].
abstract: In this paper we showed the pH-dependent change in the sensitivity of the membranes of murine peritoneal macrophages to UV-radiation. This relationship is discussed in terms of lipid bilayer membrane stability modification to the action of ROS and lipid peroxidation process (LPP) at different pH. Iron-ascorbate reinforced LPP also led to pH-dependent membranes damage. The increase of the cells incubation medium temperature up to 37 degrees C, which also stimulated LPP, did not change the picture of the pH-dependent damage. Decrease of the incubation medium pH did not reduce H2O2-induced cell damage. Increase of the pH intensified the cells damage.
authors.forename: S K
authors.initials: SK
authors.lastname: Pirutin
authors.forename: V B
authors.initials: VB
authors.lastname: Turovetskiĭ
authors.forename: A B
authors.initials: AB
authors.lastname: Druzhko
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kudriashov
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects* / Q000528:radiation effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D011836:Radiation Tolerance / Q000187:drug effects*; D014466:Ultraviolet Rays
chemical_list: D006861:Hydrogen Peroxide; D001205:Ascorbic Acid