title: High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort.
abstract: Abstract The aim of this study was to evaluate the role of S100A4 as a biomarker in patients with early rheumatoid arthritis (RA). S100A4 levels were measured in 59 patients with early RA and in 41 healthy controls. The association between the S100A4 levels and the treatment outcome after 12 months was determined using multivariate regression analysis. Serum S100A4 levels were significantly higher in the patients with early RA than in the healthy subjects and significantly decreased after 3 months of treatment. Diseases activity at 12 months was significantly higher in female patients who had initially high levels of S100A4. Persistently high S100A4 levels predicted poor treatment outcome and S100A4 may thus represent promising biomarker for assessing treatment response in patients with RA.
authors.affiliation: Institute of Rheumatology , Prague , Czech Republic .
authors.forename: Ladislav
authors.initials: L
authors.lastname: Šenolt
authors.forename: Lucie Andres
authors.initials: LA
authors.lastname: Cerezo
authors.forename: Barbora
authors.initials: B
authors.lastname: Šumová
authors.forename: Ondřej
authors.initials: O
authors.lastname: Pecha
authors.forename: Lenka
authors.initials: L
authors.lastname: Pleštilová
authors.forename: Šárka
authors.initials: Š
authors.lastname: Forejtová
authors.forename: Olga
authors.initials: O
authors.lastname: Růžičková
authors.forename: Markéta
authors.initials: M
authors.lastname: Hušáková
authors.forename: Jakub
authors.initials: J
authors.lastname: Závada
authors.forename: Karel
authors.initials: K
authors.lastname: Pavelka
authors.forename: Jiří
authors.initials: J
authors.lastname: Vencovský
authors.forename: Heřman
authors.initials: H
authors.lastname: Mann
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C077591:S100A4 protein, human
keywords: Disease activity; S100A4; response to treatment; rheumatoid arthritis