title: Water-soluble fullerene materials for bioapplications: photoinduced reactive oxygen species generation.
abstract: The photoinduced reactive oxygen species (ROS) generation from several water-soluble fullerenes was examined. Macromolecular or small molecular water-soluble fullerene complexes/derivatives were prepared and their (1)O(2) and O(2)˙(-) generation abilities were evaluated by ESR spin-trapping methods. As a result, efficient (1)O(2) generation was detected from photoexcited C(60), not only in organic solvents, but also in aqueous media and especially from small molecule C(60)-carboxylic acid derivatives. Whereas efficient O(2)˙(-) generation was observed in the aqueous solution of the C(60)/γ-CD complex under photoirradiation.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Zürich, Vladimir-Prelog-Weg 3, CH8093 Zürich, Switzerland. yamakoshi@org.chem.ethz.ch.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamakoshi
authors.forename: Safwan
authors.initials: S
authors.lastname: Aroua
authors.forename: Thach-Mien Duong
authors.initials: TM
authors.lastname: Nguyen
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ohnishi
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D037741:Fullerenes / Q000737:chemistry*; D008027:Light; D017382:Reactive Oxygen Species / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D037741:Fullerenes; D017382:Reactive Oxygen Species; D014867:Water; C069837:fullerene C60