title: Imaging phenotypes in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a common disease of the central nervous system, with various clinical symptoms and a heterogeneous disease course. MRI can depict focal and diffuse manifestations of the disease, and accurately measure progression over time. The precise pathogenesis of MS is unknown. Nevertheless, genetic influences have been found for susceptibility to MS in linkage and association studies. More recent genome-wide association studies have revealed other genes to be related to disease susceptibility and severity, explaining part of the variability in symptoms, radiological manifestations and disease course. Studies relating genetics and imaging in MS are discussed in this paper.
authors.affiliation: Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands. Electronic address: stefanmed@yahoo.com.
authors.forename: Stefan Dirk
authors.initials: SD
authors.lastname: Roosendaal
authors.affiliation: Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000235:genetics*; D010641:Phenotype
keywords: Genetics; Imaging; MR imaging; Multiple sclerosis