title: Cadherins as regulators of neuronal polarity.
abstract: A compelling amount of data is accumulating about the polyphonic role of neuronal cadherins during brain development throughout all developmental stages, starting from the involvement of cadherins in the organization of neurulation up to synapse development and plasticity. Recent work has confirmed that specifically N-cadherins play an important role in asymmetrical cellular processes in developing neurons that are at the basis of polarity. In this review we will summarize recent data, which demonstrate how N-cadherin orchestrates distinct processes of polarity establishment in neurons.
authors.affiliation: a VIB Center for the Biology of Disease; KULeuven Center for Human Genetics ; Leuven ; Belgium and KULeuven; Department of Development and Regeneration ; Leuven , Belgium.
authors.forename: Annette
authors.initials: A
authors.lastname: Gärtner
authors.forename: Eugenio F
authors.initials: EF
authors.lastname: Fornasiero
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Dotti
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion; D002465:Cell Movement; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D051379:Mice; D055495:Neurogenesis; D054261:Neurulation; D051381:Rats; D015398:Signal Transduction
chemical_list: D015820:Cadherins
keywords: N-cadherin; adhesion; axon; migration; neuronal polarity