title: Dynamic analysis of blood pressure changes in progressive cerebral infarction.
abstract: BACKGROUND
  Progressive cerebral infarction is one of the leading causes of high disability and lethality for stroke patients. However, the association between progression of BP changes and cerebral infarction is not currently well understood.
  
  
  METHODS
  We analyzed the dynamic changes in the BP of patients with acute ischemic stroke and explored the correlation between BP change and cerebral infarction progression.
  
  
  RESULTS
  30.9% (30/97) of the patients investigated developed to progressive cerebral infarction 17-141 h after admission. The percentage of patients with a long history of hypertension was significantly higher in the progressive group than in the non-progressive group. The mean systolic BP of the patients 16 h to 5 d after admission was also much higher in the progressive group. A greater abnormality of circadian blood pressure was also observed among patients in the progressive group.
  
  
  CONCLUSIONS
  Hypertension history of more than 5 years is an important risk factor for progressive cerebral infarction. Both the elevation of systolic blood pressure 16 h to 5 d after admission and abnormal circadian blood pressure are associated with the disease progression.
authors.affiliation: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Manli
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Lunzhong
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Zeying
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Xianglei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Yuyong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wei
authors.affiliation: Laiwu People's Hospital, Laiwu 271100, Shandong, PR China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Hospital, Jinan 250021, Shandong, PR China yifengdu2013@163.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Du
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002544:Cerebral Infarction / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000150:complications*; D013599:Systole
keywords: Blood pressure; Circadian variation; Progressive cerebral infarction