title: Wireless neurosensor for full-spectrum electrophysiology recordings during free behavior.
abstract: Brain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high data rate wireless neurosensor capable of recording the full spectrum of electrophysiological signals from the cortex of mobile subjects. The wireless communication system exploits a spatially distributed network of synchronized receivers that is scalable to hundreds of channels and vast environments. To demonstrate the versatility of our wireless neurosensor, we monitored cortical neuron populations in freely behaving nonhuman primates during natural locomotion and sleep-wake transitions in ecologically equivalent settings. The interface is electrically safe and compatible with the majority of existing neural probes, which may support previously inaccessible experimental and clinical research.
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA; Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Lausanne, CH-1015 Vaud, Switzerland.
authors.forename: David A
authors.initials: DA
authors.lastname: Borton
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Komar
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Naubahar
authors.initials: N
authors.lastname: Agha
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Marvell Semiconductor, 5488 Marvell Lane, Santa Clara, CA 95054, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Lausanne, CH-1015 Vaud, Switzerland.
authors.forename: Jean
authors.initials: J
authors.lastname: Laurens
authors.affiliation: Institute of Neurodegenerative diseases, Bordeaux Institut of Neuroscience, 146 Rue Léo Saignat, UMR, 33076 Bordeaux, France.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Lang
authors.affiliation: Motac Neuroscience, Lloyd Street N., Manchester, M15 6SE, UK; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, NO. 9, Dongdan san tiao, Dongcheng District, 100730 Beijing, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bull
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Larson
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA; Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, 830 Chalkstone Avenue, Providence, RI 02908, USA.
authors.forename: David
authors.initials: D
authors.lastname: Rosler
authors.affiliation: Institute of Neurodegenerative diseases, Bordeaux Institut of Neuroscience, 146 Rue Léo Saignat, UMR, 33076 Bordeaux, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, NO. 9, Dongdan san tiao, Dongcheng District, 100730 Beijing, China.
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
authors.affiliation: Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Lausanne, CH-1015 Vaud, Switzerland.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Courtine
authors.affiliation: School of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA. Electronic address: arto_nurmikko@brown.edu.
authors.forename: Arto V
authors.initials: AV
authors.lastname: Nurmikko
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology; D012890:Sleep / Q000502:physiology; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods; D014851:Wakefulness / Q000502:physiology; D016138:Walking / Q000502:physiology