title: Association of infertile patients having polycystic ovarian syndrome with recurrent miscarriage.
abstract: Polycystic ovarian syndrome (PCOS) has a pivotal role in the development of various complications during pregnancy. Polycystic ovarian syndrome women having elevated LH and hyper insulineuia may be at increased risk of miscarriage. The study was done to find out the recurrent pregnancy loss among the PCOS patient. This was a cross sectional case control study in total 100 infertile patients between age 20-40 years attending BSMMU out patient Department from July 2011 to June 2012, among them 50 infertile patients with PCOS regarding as a case and 50 infertile patients without PCOS selected as a control. Regarding case (infertile patients with PCOS) shows 20(40%) recurrent miscarriage and among control (infertile patients without PCOS) shows recurrent miscarriage 6(12%). And also among case group shows insulin resistance 8(16%) and control group insulin resistance 1(2%). Six (75%) abortion occur among PCOS with insulin resistance and 5(62.5%) abortion occur among PCOS with raised testosterone level. It is observed that recurrent miscarriage is higher in PCOS group. And also concluded that insulin resistance and raised testosterone level is responsible for this condition. So, further large scale study would be needed to reduce the chance of recurrent pregnancy loss by treatment with insulin sensitizer in case of obese PCOS with insulin resistance patient.
authors.affiliation: Dr Jesmine Banu, Associate Professor (Infertility Unit), Department of Obs & Gynae, Bangbandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
authors.forename: J
authors.initials: J
authors.lastname: Banu
authors.forename: P
authors.initials: P
authors.lastname: Fatima
authors.forename: P
authors.initials: P
authors.lastname: Sultana
authors.forename: M A
authors.initials: MA
authors.lastname: Chowdhury
authors.forename: N
authors.initials: N
authors.lastname: Begum
authors.forename: S A
authors.initials: SA
authors.lastname: Anwary
authors.forename: S
authors.initials: S
authors.lastname: Ishrat
authors.forename: F
authors.initials: F
authors.lastname: Deeba
authors.forename: S A
authors.initials: SA
authors.lastname: Begum
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female; D007328:Insulin / Q000652:urine; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D013739:Testosterone / Q000097:blood
chemical_list: D007328:Insulin; D013739:Testosterone