title: Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant.
abstract: Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.
authors.affiliation: Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India.
authors.forename: Kanthilatha
authors.initials: K
authors.lastname: Pai
authors.affiliation: Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Shricharith
authors.initials: S
authors.lastname: Shetty
authors.affiliation: Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: J
authors.initials: J
authors.lastname: Padmapriya
authors.affiliation: Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Sathish
authors.initials: S
authors.lastname: Pai
authors.affiliation: Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Rao
keywords: Acantholytic; Bowens’ disease; squamous cell carcinoma