title: Geissoschizine methyl ether N-oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla.
abstract: Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC₅₀ value of 23.4 μM.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , People's Republic of China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Jiang
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000302:isolation & purification; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D032070:Uncaria / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D003497:Cyclic N-Oxides; D026121:Indole Alkaloids; C110832:geissoschizine methylether
keywords: Rubiaceae; Uncaria rhynchophylla; alkaloids; anti-AChE activity; geissoschizine methyl ether N-oxide