title: Asymmetric synthesis of trisubstituted aziridines via aza-Darzens reaction of chiral sulfinimines.
abstract: The aza-Darzens reaction of substituted 2-bromoesters with chiral tert-butane- and mesitylsulfinimines provides a rapid access to a range of highly substituted aziridines in good yields and excellent levels of stereoselectivity. The synthetic potential of this protocol is further enhanced by the successful removal of the sulfinyl motif, yielding simple access to chiral N-H aziridines in just three steps from commercial aldehyde precursors.
authors.affiliation: School of Chemistry, University of Nottingham , Nottingham, NG7 2RD, U.K.
authors.forename: Toni
authors.initials: T
authors.lastname: Moragas
authors.forename: Ian
authors.initials: I
authors.lastname: Churcher
authors.forename: William
authors.initials: W
authors.lastname: Lewis
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockman