title: [Effect of polyoxyalkanoate -based cover on properties of suture material].
abstract: The results of a surgical intervention and, in particular, reconstructive operations on arteries are largely influenced by suture material. Despite a wide range of choice, the market concerned lacks suture material which would make it possible to decrease the risk of thrombosis in the area of the vascular anastomosis. In order to increase bio- and haemocompatibility, the surface of a polypropylene thread was covered with a layer based on polyoxyalkanoates - polyhydroxybutyrate and copolymer polyhydroxybutyrate-oxyvaleriate (PHBV). The strongest and most uniformly distributed coating of the polypropylene thread was provided by PHBV. We assessed the bio- and haemocompatibility properties of suture material modified by PHBV, revealing that this modification does not exert negative effect on the main components of blood - thrombocytes and erythrocytes. Treatment of the thread's surface with PHBV promoted a significant (p<0.05) decrease in the amount of absorbed proteins in the area of the vascular anastomosis in experiment: the amount of IgM decreased by 26%, that of fibrinogen by 29%, and that of D-Dimer by 281%, being on the whole indicative of bio- and haemocompatibility of the modified suture material.
authors.forename: T N
authors.initials: TN
authors.lastname: Akent'eva
authors.forename: V V
authors.initials: VV
authors.lastname: Borisov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kudriavtseva
authors.forename: N V
authors.initials: NV
authors.lastname: Doronina
authors.forename: V A
authors.initials: VA
authors.lastname: Ezhov
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D000818:Animals; D001158:Arteries / Q000601:surgery*; D002318:Cardiovascular Diseases / Q000601:surgery*; D013504:Cardiovascular Surgical Procedures / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D004195:Disease Models, Animal; D008422:Materials Testing / Q000379:methods; D011091:Polyesters / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013537:Sutures / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D000094122:Polyhydroxybutyrates
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates