title: A split personality for nucleosomes.
abstract: A high-resolution look at where histones touch DNA reveals a surprisingly intricate, dynamic, and modular nucleosome. Three advances in the study by Rhee et al. include unexpected interactions between the H3 tail and linker DNA, new evidence for existence of subnucleosomal particles, and asymmetric patterns of histone modification within a single nucleosome that correspond to the direction of transcription.
authors.affiliation: Department of Biology, Department of Genetics, Integrative Program for Biological and Genome Sciences, The University of North Carolina at Chapel Hill, 250 Bell Tower Drive, Chapel Hill, NC 27599, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: McKay
authors.affiliation: Department of Human Genetics, The University of Chicago, 920 East 58(th) Street, Chicago, IL, 60637, USA. Electronic address: jdlieb@uchicago.edu.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Lieb
mesh_terms: D009707:Nucleosomes / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D009707:Nucleosomes