title: Epstein-Barr virus: dermatologic associations and implications: part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders.
abstract: Epstein-Barr virus (EBV) is a ubiquitous virus that has been implicated in a wide range of human diseases, many of which have mucocutaneous manifestations. As a member of the herpesviridae family, EBV causes lifelong infection by establishing latency in B lymphocytes. An intact immune response is critical in preventing progression of EBV disease, and the clinical manifestations of infection are dependent on the intricate relationship between virus and host immune system. This review provides a comprehensive overview of the epidemiology, pathophysiology, and diagnostic testing in EBV infection. In part I of this continuing medical education article, the mucocutaneous manifestations of EBV infection are reviewed with an emphasis on pathophysiology and management.
authors.affiliation: Ackerman Academy of Dermatopathology, New York, New York. Electronic address: davehall1012@gmail.com.
authors.forename: Lawrence David
authors.initials: LD
authors.lastname: Hall
authors.affiliation: Geisinger Medical Center, Danville, Pennsylvania.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Eminger
authors.affiliation: Tulane University Medical Center, New Orleans, Louisiana.
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Hesterman
authors.affiliation: Cooper Medical School of Rowan University, Camden, New Jersey; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Warren R
authors.initials: WR
authors.lastname: Heymann
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006837:Hydroa Vacciniforme / Q000821:virology; D007244:Infectious Mononucleosis / Q000821:virology; D017733:Leukoplakia, Hairy / Q000821:virology; D009092:Mucous Membrane; D012874:Skin Diseases, Infectious / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology*
keywords: Epstein-Barr virus; heterophile antibodies; histiocytic necrotizing lymphadenitis; human herpes virus 4; hydroa vacciniforme; infectious mononucleosis; latency; lymphoproliferative; nonsexually related acute genital ulcers; oral hairy leukoplakia; papular acrodermatitis of childhood