title: Synthesis and insecticidal activity of new oxime derivatives of podophyllotoxin-based phenazines against Mythimna separata Walker.
abstract: To discover new natural-product-based insecticidal agents, a series of novel oxime derivatives of podophyllotoxin-based phenazines modified in the C, D and E rings of podophyllotoxin were prepared and tested as insecticidal agents against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1 mg/mL. The steric configuration of IIIc was unambiguously confirmed by single-crystal X-ray diffraction analysis. Compounds IIIa-d, and IIIi exhibited an equal or higher insecticidal activity than toosendanin.
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China. Electronic address: orgxuhui@nwsuaf.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects*; D015394:Molecular Structure; D009036:Moths; D010091:Oximes / Q000737:chemistry*; D010619:Phenazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011034:Podophyllotoxin / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007306:Insecticides; D010091:Oximes; D010619:Phenazines; D011034:Podophyllotoxin
keywords: Insecticidal activity; Mythimna separata Walker; Natural-product-based insecticide; Oxime; Phenazine; Podophyllotoxin