title: The potential of 12/15-lipoxygenase inhibitors in stroke therapy.
authors.affiliation: Neuroprotection Research Laboratory, Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
authors.forename: Klaus
authors.initials: K
authors.lastname: van Leyen
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holman
authors.forename: David J
authors.initials: DJ
authors.lastname: Maloney
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001092:Arachidonate 12-Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D001093:Arachidonate 15-Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: C475064:12-15-lipoxygenase; D016859:Lipoxygenase Inhibitors; D018696:Neuroprotective Agents; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase; D010959:Tissue Plasminogen Activator
keywords: edema; eicosanoid; hemorrhage; ischemia; lipoxygenase; oxidative stress; stroke; tissue plasminogen activator