title: Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: a resting state functional magnetic imaging study.
abstract: Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated with suicidal behavior by comparing local synchronization of resting-state functional magnetic resonance imaging signals in suicide attempters without a psychiatric diagnosis (SA group, 19.84±1.61 years, n=19) with those in healthy controls (HC group, 20.30±1.72 years, n=20) using regional homogeneity (ReHo) analysis. The SA group exhibited significantly lower mean ReHo in the left (L) fusiform and supraorbital inferior frontal gyri, L hippocampus, bilateral parahippocampal and middle frontal gyri, right (R) angular gyrus, and cerebellar lobules RVIII, RII, and LVI compared with the HC group. Conversely, in the SA group, ReHo was higher in the R supraorbital middle frontal gyrus, R inferior parietal lobe, and L precuneus. The SA group also had significantly higher total Barratt Impulsiveness Scale scores compared with the HC group. Local functional connectivity is altered in multiple regions of the cerebral cortex, limbic system, and cerebellum of suicidal young adults. Elucidating the functional deficits associated with these ReHo changes may clarify the pathophysiological mechanisms of suicidal behavior and assist in identifying high-risk individuals.
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jian-mei
authors.initials: JM
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: kuangli0308@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Kuang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ai
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Fang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Gan
authors.affiliation: Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China.
authors.forename: Wo
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Heng-guang
authors.initials: HG
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lv
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002531:Cerebellum / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D013406:Suicide, Attempted / Q000523:psychology; D055815:Young Adult
keywords: Attempted suicide; Cerebellum; Cerebral cortex; Hippocampus; Impulsive behavior; fMRI