title: Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development.
abstract: Hepatocellular carcinoma (HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis (NASH). NASH is a complex metabolic disorder that can impact greatly on hepatic function. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give an overview of the recent novel mechanisms published that have been associated with NASH and subsequent HCC progression. We will focus our discussion on inflammation and gut derived inflammation and how they contribute to NASH driven HCC.
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Chun-Meng
authors.initials: CM
authors.lastname: Jiang
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Chun-Wen
authors.initials: CW
authors.lastname: Pu
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Hou
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alanazy
authors.affiliation: Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
authors.forename: Lionel
authors.initials: L
authors.lastname: Hebbard
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D018836:Inflammation Mediators
keywords: Bile acids; Hepatocellular carcinoma; Inflammation; Microbiome; Nonalcoholic steatohepatitis