title: Asymmetric dimethylarginine is associated with carotid atherosclerosis in patients with essential hypertension.
abstract: This study was to assess the relationship between asymmetric dimethylarginine (ADMA) and carotid atherosclerosis in patients with essential hypertension. A total of 182 individuals with never-treated essential hypertension and 182 age-matched healthy controls were studied. Plasma ADMA levels, mean intima-media thickness (IMT) and plaque score were significantly greater in hypertensive patients than normotensive controls. ADMA was positively correlated with mean IMT. On multiple logistic regression analysis, ADMA was a crucial independent predictor of carotid plaque formation (plaque score ≥1.1). Our results suggest that increased levels of ADMA are associated with the development of carotid atherosclerosis in hypertensive patients.
authors.affiliation: Department of Cardiology, Qingdao Municipal Hospital , Shandong , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Wenliang
authors.initials: W
authors.lastname: Xu
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Yao
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D002340:Carotid Artery Diseases / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018608:Ultrasonography, Doppler
chemical_list: D015415:Biomarkers; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Asymmetric dimethylarginine; atherosclerosis; carotid plaque; essential hypertension; intima-media thickness