title: Steroid unresponsive case of ulcerative mucha-habermann disease (febrile ulcernecrotic mucha-habermann disease) treated with methotrexate.
abstract: A 20 year old male presented with fever associated with eruption of papules, plaques and vesiculobullous lesions on the chest, back, extremities, palms, soles, and genital mucosa of 20 days duration. Histopathological examination revealed epidermal clefts, edema and vacuolar degeneration of keratinocytes, basal cell degeneration, and dermal perivascular lymphocytic infiltrate. On the basis of clinical features and histology, a diagnosis of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) was made. Treatment with doxycycline (100 mg BD for 4 weeks) and oral prednisolone 60 mg/day tapered to 25 mg in 4 weeks led to initial response that was followed by a relapse on tapering steroid. Addition of methotrexate (7.5 mg increased to 15 mg in 2 weeks) led to a dramatic response.
authors.affiliation: Department of Dermatology, INHS Asvini, Colaba, Mumbai, Maharashtra, India.
authors.forename: Deepam J
authors.initials: DJ
authors.lastname: Shah
authors.affiliation: Department of Dermatology, INHS Asvini, Colaba, Mumbai, Maharashtra, India ; Department of Venerology, INHS Asvini, Colaba, Mumbai, Maharashtra, India ; Department of Lerprosy, INHS Asvini, Colaba, Mumbai, Maharashtra, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Dhir
authors.affiliation: Department of Dermatology, INHS Asvini, Colaba, Mumbai, Maharashtra, India.
authors.forename: Harsh
authors.initials: H
authors.lastname: Shah
authors.affiliation: Department of Pathology, INHS Asvini, Colaba, Mumbai, Maharashtra, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Chawla
keywords: Febrile ulceronecrotic mucha-habermann disease; methotrexate; steroids