title: A hub for ABA signaling to the nucleus: significance of a cytosolic and nuclear dual-localized PPR protein SOAR1 acting downstream of Mg-chelatase H subunit.
abstract: SOAR1 is a cytosol-nucleus dual-localized pentatricopeptide repeat (PPR) protein, which we indentified recently as a crucial regulator in the CHLH/ABAR (Mg-chelatase H subunit /putative ABA receptor)-mediated signaling pathway, acting downstream of CHLH/ABAR and upstream of a nuclear ABA-responsive bZIP transcription factor ABI5. Downregulation and upregulation of SOAR1 expression alter dramatically both ABA sensitivity and expression of a subset of key, nuclear ABA-responsive genes, suggesting that SOAR1 is a hub for ABA signaling to the nucleus, and CHLH/ABAR mediates a central signaling pathway to regulate downstream gene expression through SOAR1.
authors.affiliation: a MOE Systems Biology and Bioinformatics Laboratory; Center for Plant Biology; School of Life Sciences ; Tsinghua University ; Beijing , China.
authors.forename: Shang-Chuan
authors.initials: SC
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Mei
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Zhang
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D008190:Lyases / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D021122:Protein Subunits; C538752:pentatricopeptide repeat protein, Arabidopsis; D000040:Abscisic Acid; D008190:Lyases; C086788:magnesium chelatase
keywords: ABA receptor; ABA signaling; ABA, abscisic acid; ABAR, putative ABA receptor; CHLH, Mg-chelatase H subunit; CPN20, cochaperonin 20; Mg-chelatase H subunit; PPR, pentatricopeptide repeat; SOAR1, suppressor of the ABAR-overexpressor 1; WRKY, WRKY-domain transcription factor; cytosol-nucleus dual-localization; pentatricopeptide repeat (PPR) protein