title: Development of new strategies for early diagnosis of mucormycosis from bench to bedside.
abstract: Early diagnosis and initiation of amphotericin B (AmB) for treatment of mucormycosis increases survival from approximately 40% to 80%. The central objective of a new study of the European Confederation of Medical Mycology (ECMM) and the International Society for Human and Animal Mycology (ISHAM) Zygomycosis Working Group is to improve the clinical and laboratory diagnosis of mucormycosis. The diagnostic tools generated from this study may help to significantly improve survival from mucormycosis worldwide. The study has three major objectives: to conduct a prospective international registration of patients with mucormycosis using a well-established global network of centres; to construct a predictive risk model for patients at risk for mucormycosis; and to establish an international archive of specimens of tissues, fluids, and organisms linked from the patients enrolled into the registry that will be used for development of leading edge molecular, proteomic, metabolic and antigenic systems for mucormycosis.
authors.affiliation: Henry Schueler Foundation Scholar in Mucormycosis, Transplantation-Oncology Infectious Diseases Program, Infectious Diseases Translational Research Laboratory, Departments of Medicine, Pediatrics, and Microbiology and Immunology, Weill Cornell Medical Center of Cornell University, New York, NY, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Anna
authors.initials: A
authors.lastname: Skiada
authors.forename: Oliver A
authors.initials: OA
authors.lastname: Cornely
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
authors.forename: Ashraf
authors.initials: A
authors.lastname: Ibrahim
authors.forename: Theoklis
authors.initials: T
authors.lastname: Zaoutis
authors.forename: Andreas
authors.initials: A
authors.lastname: Groll
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: George
authors.initials: G
authors.lastname: Petrikkos
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D016208:Databases, Factual; D003952:Diagnostic Imaging; D042241:Early Diagnosis; D006801:Humans; D008828:Microbiological Techniques; D009090:Mucorales / Q000472:pathogenicity*; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy; D012042:Registries; D018570:Risk Assessment; D012958:Societies, Scientific; D013048:Specimen Handling
chemical_list: D000935:Antifungal Agents
keywords: diagnosis; epidemiology; mucormycosis; network; zygomycosis