title: Interactions of selected gold(III) complexes with DNA G quadruplexes.
abstract: The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III) complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation, turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear the way for novel biological and pharmacological applications of this class of metal compounds.
authors.affiliation: Department NEUROFARBA - Pharmaceutical and nutraceutical section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gratteri
authors.forename: L
authors.initials: L
authors.lastname: Massai
authors.forename: E
authors.initials: E
authors.lastname: Michelucci
authors.forename: R
authors.initials: R
authors.lastname: Rigo
authors.forename: L
authors.initials: L
authors.lastname: Messori
authors.forename: M A
authors.initials: MA
authors.lastname: Cinellu
authors.forename: C
authors.initials: C
authors.lastname: Musetti
authors.forename: C
authors.initials: C
authors.lastname: Sissi
authors.forename: C
authors.initials: C
authors.lastname: Bazzicalupi
mesh_terms: D002942:Circular Dichroism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D054856:G-Quadruplexes; D006046:Gold / Q000737:chemistry*; D006801:Humans; D009690:Nucleic Acid Conformation; D021241:Spectrometry, Mass, Electrospray Ionization; D020349:Surface Plasmon Resonance
chemical_list: D056831:Coordination Complexes; D006046:Gold