title: Degradation of antidepressant drug fluoxetine in aqueous media by ozone/H2O2 system: process optimization using central composite design.
abstract: The main objective of this work is the modelling and optimization of antidepressant drug fluoxetine degradation in aqueous solution by ozone/H2O2 process using central composite design. The operational parameters were ozone concentration, initial hydrogen peroxide concentration, reaction time and initial fluoxetine concentration. A good agreement between the predicted values of fluoxetine removal and experimental results were observed (R2=0.976 and Adj-R2=0.955). Pareto analysis indicated that all selected factors and some interactions were effective on the removal efficiency. It was found that the reaction time is the most effective parameter in the ozone/H2O2 process. The maximum removal efficiency (86.14%) was achieved at ozone concentration of 30 mg L(-1), initial H2O2 concentration of 0.02 mM, reaction time of 20 min and initial fluoxetine concentration of 50 mg L(-1) as the optimum conditions.
authors.affiliation: a Department of Chemical Engineering , Environmental Engineering Research Centre, Sahand University of Technology , Tabriz , Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Aghaeinejad-Meybodi
authors.forename: Amanollah
authors.initials: A
authors.lastname: Ebadi
authors.forename: Sirous
authors.initials: S
authors.lastname: Shafiei
authors.forename: Alireza
authors.initials: A
authors.lastname: Khataee
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rostampour
mesh_terms: D005473:Fluoxetine / Q000737:chemistry*; D006861:Hydrogen Peroxide; D010126:Ozone; D013223:Statistics as Topic; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D014874:Water Pollutants, Chemical; D005473:Fluoxetine; D010126:Ozone; D006861:Hydrogen Peroxide
keywords: central composite design; fluoxetine; ozonation; pharmaceutical wastewater; response surface methodology