title: Granulomatous cheilitis with intralymphatic histiocytosis possibly associated with calcium deposition caused by chronic inflammation owing to dental metals and periodontitis.
abstract: Granulomatous cheilitis (GC) is an uncommon disease and the pathogenesis of GC has not been clear. Here, we present two cases of GC associated with calcium deposition caused by chronic inflammation owing to dental metal allergy and periodontitis. Histopathologically, intralymphatic histiocytosis (IH) in addition to non-caseating granulomas was seen in both cases. The results of a patch test were positive for some dental metals. Qualitative analyses by energy-dispersive X-ray spectroscopy detected calcium from biopsy specimens. We considered that partial destruction of teeth by chronic inflammation induced reactive proliferation of histiocytes, resulting in IH. Our study suggests that GC and IH is a consequence of chronic inflammatory diseases caused by dental metals and periodontitis. Dental care is necessary for treatment of GC.
authors.affiliation: Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kano
authors.forename: Shingo
authors.initials: S
authors.lastname: Kurimoto
authors.forename: Ayako
authors.initials: A
authors.lastname: Ito
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000209:etiology; D017266:Dental Prosthesis / Q000009:adverse effects*; D015614:Histiocytosis / Q000209:etiology; D006801:Humans; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000209:etiology*; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications*
chemical_list: D008670:Metals
keywords: X-ray spectroscopy; cheilitis; granuloma; histiocyte; histopathology