title: Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011.
abstract: BACKGROUND
  PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines.
  
  
  METHODS
  We performed sequence analysis of meningococcal porA, fetA and fHbp genes on 128 isolates from Western Australia, relating results to age, gender, race and geographic region.
  
  
  RESULTS
  We found predominantly PorA subtypes P1.22,14-16 (n = 23) and P1.7-2,4 (n = 19); FetA subtypes F1-5 (n = 41), F3-6 (n = 11), F5-1 (n = 10), F5-2 (n = 9), F5-5 (n = 8), F3-3 (n = 8); and FHbp variant groups 1 (n = 65) and 2 (n = 44). PorA P1.22,14-16 and FHbp variant group 2 were associated with younger age and aboriginality.
  
  
  CONCLUSIONS
  FHbp modular groups of the bivalent recombinant FHbp vaccine and the multicomponent 4CMenB vaccine make up 8.3% and 47.7% respectively of the examined serogroup B isolates from 2000-2011, however to estimate vaccine efficacy requires an account of all vaccine antigens and their levels of expression.
authors.affiliation: Department of Microbiology, PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Australia. Peter.Boan@health.wa.gov.au.
authors.forename: Peter
authors.initials: P
authors.lastname: Boan
authors.forename: Norhaliza
authors.initials: N
authors.lastname: Metasan
authors.forename: Simone
authors.initials: S
authors.lastname: Tempone
authors.forename: Gerry
authors.initials: G
authors.lastname: Harnett
authors.forename: David J
authors.initials: DJ
authors.lastname: Speers
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Keil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000382:microbiology* / Q000517:prevention & control; D022401:Meningococcal Vaccines; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000235:genetics* / Q000276:immunology; D018272:Porins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014611:Vaccination; D014904:Western Australia; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C093120:FrpB protein, bacteria; D022401:Meningococcal Vaccines; D018272:Porins; C484699:factor H-binding protein, Neisseria meningitidis; C057699:porin protein, Neisseria