title: DOTting the path to doom: how acceleration of histone methylation leads to leukemia.
abstract: Epigenetic control mechanisms are central to normal and malignant hematopoiesis. In this issue of Cancer Cell, Deshpande and colleagues demonstrate that AF10, an interaction partner of the histone methyltransferase DOT1L, is essential for efficient H3K79 methylation, thus regulating HOX-gene transcription and transformation in myeloid leukemia.
authors.affiliation: Department of Internal Medicine 5, Hematology/Oncology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Bach
authors.affiliation: Division of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erwin-Rommelstrasse 3, 91058 Erlangen, Germany. Electronic address: robert.slany@fau.de.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Slany
mesh_terms: D000818:Animals; D006657:Histones / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism* / Q000473:pathology*; D008780:Methyltransferases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D006657:Histones; D018398:Homeodomain Proteins; D014157:Transcription Factors; D008780:Methyltransferases