title: Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction.
abstract: Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Ofek Y
authors.initials: OY
authors.lastname: Hai
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Mentz
authors.forename: Faiez
authors.initials: F
authors.lastname: Zannad
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gasparini
authors.forename: Gaetano M
authors.initials: GM
authors.lastname: De Ferrari
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Daubert
authors.forename: Johannes
authors.initials: J
authors.lastname: Holzmeister
authors.forename: Carolyn S P
authors.initials: CS
authors.lastname: Lam
authors.forename: Thierry
authors.initials: T
authors.lastname: Pochet
authors.forename: Alphons
authors.initials: A
authors.lastname: Vincent
authors.forename: Cecilia
authors.initials: C
authors.lastname: Linde
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000628:therapy*
keywords: Cardiac resynchronization therapy; Heart failure; Left ventricular ejection fraction; Reverse cardiac remodelling