title: Functional block copolymer nanoparticles: toward the next generation of delivery vehicles.
abstract: The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyesviacopper catalyzed azide alkyne cycloaddition 'click' chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditionsviathe degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.
authors.affiliation: Department of Chemistry and Biochemistry, Materials Department, and Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Maxwell J
authors.initials: MJ
authors.lastname: Robb
authors.affiliation: Department of Chemistry and Biochemistry, Materials Department, and Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Luke A
authors.initials: LA
authors.lastname: Connal
authors.affiliation: Department of Chemistry and Biochemistry, Materials Department, and Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Bongjae F
authors.initials: BF
authors.lastname: Lee
authors.affiliation: Department of Chemistry and Biochemistry, Materials Department, and Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Nathaniel A
authors.initials: NA
authors.lastname: Lynd
authors.affiliation: Department of Chemistry and Biochemistry, Materials Department, and Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA ; King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia 31261.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker