title: How pathogens use linear motifs to perturb host cell networks.
abstract: Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies.
authors.affiliation: Department of Physics, Sapienza University, 00185 Rome, Italy.
authors.forename: Allegra
authors.initials: A
authors.lastname: Via
authors.affiliation: Structural and Computational Biology, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
authors.forename: Bora
authors.initials: B
authors.lastname: Uyar
authors.affiliation: Inserm, UMR1090 TAGC, Marseille F-13288, France; Aix-Marseille Université, UMR1090 TAGC, Marseille F-13288, France; CNRS, Marseille F-13402, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Brun
authors.affiliation: Inserm, UMR1090 TAGC, Marseille F-13288, France; Aix-Marseille Université, UMR1090 TAGC, Marseille F-13288, France. Electronic address: zanzoni@tagc.univ-mrs.fr.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zanzoni
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics*; D000818:Animals; D001665:Binding Sites; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D018716:Molecular Mimicry / Q000235:genetics*; D010944:Plants / Q000235:genetics / Q000821:virology; D060066:Protein Interaction Maps / Q000235:genetics; D014774:Virulence / Q000235:genetics; D014780:Viruses / Q000235:genetics* / Q000472:pathogenicity
keywords: SLiMs; host–pathogen interactions; molecular mimicry; short linear motifs; virulence