title: Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women.
abstract: OBJECTIVE
  To measure serum osteocalcin (OC), under-carboxylated osteocalcin (ucOC), osteopontin (OPN), and leptin in pregnant women with gestational diabetes mellitus (GDM) and in healthy pregnant women during pregnancy and after birth and relate these markers to glucose metabolism.
  
  
  METHODS
  This was a prospective study including 60 women with GDM and 60 subjects with normal gestation who were evaluated at gestational week 30 and 6 weeks postpartum. Serum OC, ucOC, OPN, leptin, insulin and insulin resistance were evaluated during the study.
  
  
  RESULTS
  Bone biomarkers and leptin were similar between GDM and normal pregnancy. After delivery, OC, ucOC and OPN increased in both groups, while leptin decreased only in healthy controls. Bone markers did not correlate with insulin and insulin resistance in the two groups, but leptin was positively correlated with insulin and insulin resistance and negatively correlated with bone biomarkers only in healthy women. Furthermore, the women who developed diabetes postpartum had lower levels of OC than women with normal glucose tolerance.
  
  
  CONCLUSIONS
  GDM is not associated with OC, ucOC, OPN, and leptin and does not correlate with insulin resistance. At postpartum, women who develop diabetes have lower osteocalcin concentrations. Leptin correlates with insulin resistance and bone biomarkers in non-diabetic women.
authors.affiliation: Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720, Mexico City, Mexico. sgrenata@yahoo.com.
authors.forename: R
authors.initials: R
authors.lastname: Saucedo
authors.affiliation: Unit of Experimental Medicine, UNAM, Mexico City, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Rico
authors.affiliation: Unit of Experimental Medicine, UNAM, Mexico City, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Vega
authors.affiliation: Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720, Mexico City, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Basurto
authors.affiliation: Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720, Mexico City, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Cordova
authors.affiliation: Gerontology Research Unit, UNAM, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Galvan
authors.affiliation: Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720, Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Hernandez
authors.affiliation: Hospital of Gynecology and Obstetrics, Medical Center La Raza, IMSS, Mexico City, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Puello
authors.affiliation: Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720, Mexico City, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Zarate
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D015675:Osteocalcin / Q000097:blood*; D053495:Osteopontin / Q000097:blood*; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
chemical_list: D015415:Biomarkers; D020738:Leptin; D015675:Osteocalcin; D053495:Osteopontin
keywords: Gestational diabetes mellitus; Insulin resistance; Osteocalcin; Osteopontin; Under-carboxylated osteocalcin