title: Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review.
abstract: IMRT has been suggested to reduce treatment-related toxicity in pancreatic cancer. We attempted to identify all IMRT-studies indexed in PubMed/Medline, comparing them with recent 3D-CRT trials. The predominant treatment-related toxicities, namely nausea/vomiting, diarrhoea and late GI toxicity, are significantly reduced with IMRT while there was no apparent difference for outcome measures.
authors.affiliation: Department of Radiation Oncology, University Medical Centre Freiburg, Germany; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK(1).
authors.forename: Martin-Immanuel
authors.initials: MI
authors.lastname: Bittner
authors.affiliation: Department of Radiation Oncology, University Medical Centre Freiburg, Germany.
authors.forename: Anca-Ligia
authors.initials: AL
authors.lastname: Grosu
authors.affiliation: Department of Radiation Oncology, University Medical Centre Freiburg, Germany. Electronic address: thomas.brunner@uniklinik-freiburg.de.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Brunner
mesh_terms: D005767:Gastrointestinal Diseases / Q000209:etiology; D006402:Hematologic Diseases / Q000209:etiology; D006801:Humans; D009325:Nausea / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D014839:Vomiting / Q000209:etiology
keywords: IMRT; Pancreatic cancer; Radiotherapy planning; Toxicity