title: Nanogel Carrier Design for Targeted Drug Delivery.
abstract: Polymer-based nanogel formulations offer features attractive for drug delivery, including ease of synthesis, controllable swelling and viscoelasticity as well as drug loading and release characteristics, passive and active targeting, and the ability to formulate nanogel carriers that can respond to biological stimuli. These unique features and low toxicity make the nanogels a favorable option for vascular drug targeting. In this review, we address key chemical and biological aspects of nanogel drug carrier design. In particular, we highlight published studies of nanogel design, descriptions of nanogel functional characteristics and their behavior in biological models. These studies form a compendium of information that supports the scientific and clinical rationale for development of this carrier for targeted therapeutic interventions.
authors.affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Eckmann
authors.affiliation: Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Composto
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Tsourkas
authors.affiliation: Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Muzykantov
keywords: endothelial targeting; nanocarrier; nanogel; targeted drug delivery