title: [Influence of immunoregulatory cytokines (IL-2, IL-7 and IL-15) in vitro upon activation, proliferation and apoptosis of immune memory T-cells].
abstract: Under the experimental conditions in vitro the effects of immunoregulatory cytokines (IL-2, IL-7 and IL-15) on the activation, proliferation and apoptosis of different subpopulations of immune memory T-cell (Cd45RO+) were investigated in healthy donors. It was demonstrated that the effects of rlL-2 in vitro equally affect the activation and proliferation of CD4+ and CD8+ subpopulations of memory T cells. It has been shown that high concentrations of rIL-2 lead to an increase in the number of CD8+ memory cells expressing apoptotic molecule CD95. Different effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic CD8+ memory ells has been revealed in vitro. CD4+ memory lymphocytes have relative resistance to the activation and proliferative effect of rlL-7 and rlL-15, if compared with the effects of rIL-2, which can provide their relative resistance to the activation apoptosis as well as create the necessary conditions for the accelerated implementation of their functional capacity in the development of a secondary immune response.
authors.forename: L S
authors.initials: LS
authors.lastname: Litvinova
authors.forename: N A
authors.initials: NA
authors.lastname: Sokhonevich
authors.forename: A A
authors.initials: AA
authors.lastname: Gutsol
authors.forename: K A
authors.initials: KA
authors.lastname: Kofanova
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D019409:Interleukin-15 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D015851:Interleukin-7 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D061251:Primary Cell Culture; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: C569274:IL15 protein, human; C508605:IL7 protein, human; D019409:Interleukin-15; D007376:Interleukin-2; D015851:Interleukin-7; D011994:Recombinant Proteins