title: Time to overcome the high, long, and bumpy free energy barrier in a multi-stage process: the generalized steady-state approach.
abstract: This paper presents a simple but general analytical estimate of the characteristic time of crossing a long, high, and arbitrary bumpy free energy barrier in the course of a sequential (one-dimensional) chemical, biochemical, or physical reaction. This estimate is based on a generalized steady-state approach developed in this paper.
authors.affiliation: Laboratory of Protein Physics, Institute of Protein Research, Russian Academy of Sciences , 142290, Pushchino, Moscow Region, Russian Federation.
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Finkelstein
mesh_terms: D013816:Thermodynamics; D013997:Time Factors