title: Long non-coding RNAs and hepatocellular carcinoma.
abstract: Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.
authors.affiliation: Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508.
authors.forename: Fu-Jun
authors.initials: FJ
authors.lastname: Yu
authors.affiliation: Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
authors.forename: Jian-Jian
authors.initials: JJ
authors.lastname: Zheng
authors.affiliation: Wenzhou Key Laboratory of Surgery, Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Fan
keywords: H19; HOX antisense intergenic RNA; downregulated expression by HBx; hepatocellular carcinoma; high expression in HCC; highly upregulated in liver cancer; long non-coding RNA; maternally expressed gene 3; metastasis associated lung adenocarcinoma transcript 1; microvascular invasion in HCC