title: Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma.
abstract: Hydroxyurea (HU) is an antineoplastic drug used in the treatment of chronic myeloproliferative neoplasms (MPNs). HU is associated with cutaneous adverse effects, whereas severe complications such as leg ulcers and non-melanoma skin cancers (NMSCs) are rare and only observed after long-term treatment. We herein report a patient with essential thrombocythemia (ET) treated chronically with HU, and who developed refractory bilateral leg ulcers complicated by squamous cell carcinoma (SCC) over both heels. The patient was successfully managed by multiple debridement stages and skin grafting surgeries.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Antar
authors.affiliation: Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Rim S
authors.initials: RS
authors.lastname: Ishak
authors.affiliation: Department of Pathology and Immunology, Washington University, Barnes-Jewish Hospital, St. Louis, MO, USA.
authors.forename: Zaher K
authors.initials: ZK
authors.lastname: Otrock
authors.affiliation: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Nadim
authors.initials: N
authors.lastname: El-Majzoub
authors.affiliation: Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Samer
authors.initials: S
authors.lastname: Ghosn
authors.affiliation: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Rami
authors.initials: R
authors.lastname: Mahfouz
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: ataher@aub.edu.lb.
authors.forename: Ali T
authors.initials: AT
authors.lastname: Taher
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000009:adverse effects*; D007871:Leg Ulcer / Q000139:chemically induced* / Q000601:surgery*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D006918:Hydroxyurea
keywords: Essential thrombocythemia; Hydroxyurea; Squamous cell carcinoma