title: Beyond boundaries--Eph:ephrin signaling in neurogenesis.
abstract: Eph:ephrin signaling plays an important role in embryonic development as well as tissue homeostasis in the adult. At the cellular level, this transduction pathway is best known for its role in the control of cell adhesion and repulsion, cell migration and morphogenesis. Yet, a number of publications have also implicated Eph:ephrin signaling in the control of adult and embryonic neurogenesis. As is the case for other biological processes, these studies have reported conflicting and sometimes opposite roles for Eph:ephrin signaling in neurogenesis. Herein, we review these studies and we discuss existing mathematical models of stem cell dynamics and neurogenesis that provide a coherent framework and may help reconcile conflicting results.
authors.affiliation: a Centre de Biologie du Développement; CNRS; Université de Toulouse ; Toulouse , France.
authors.forename: J
authors.initials: J
authors.lastname: Laussu
authors.forename: A
authors.initials: A
authors.lastname: Khuong
authors.forename: J
authors.initials: J
authors.lastname: Gautrais
authors.forename: A
authors.initials: A
authors.lastname: Davy
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D002448:Cell Adhesion; D002465:Cell Movement; D002945:Cisplatin; D047108:Embryonic Development; D036342:Ephrins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007069:Ifosfamide; D016685:Mitomycin; D008962:Models, Theoretical; D009024:Morphogenesis; D055495:Neurogenesis; D011247:Pregnancy; D011485:Protein Binding; D036081:Receptors, Eph Family / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology
chemical_list: D036342:Ephrins; D016685:Mitomycin; D036081:Receptors, Eph Family; D002945:Cisplatin; D007069:Ifosfamide
keywords: Eph receptors; SVZ; adult stem cells; development; ephrin; model; neocortex; neural progenitors; neurogenesis; population dynamics, SGZ