title: Stabilization of ribofuranose by a mineral surface.
abstract: The existence of the ribose moiety in biomolecules poses two problems for prebiotic chemistry. First, the exclusive presence of the furanose isomer in RNA has to be accounted for since furanose is a minor form in solution and does not exist in crystals. Second, all D-ribose polymorphs are unstable in aqueous medium so that a stabilization mechanism has to be invoked. We observed that the adsorption on mineral surfaces as amorphous silica protects the sugar from degradation processes. Moreover, this silica surface, used as realistic chert model, is able to increase significantly the proportion of ribofuranose compared to ribopyranose forms. The interaction between surface and sugar was analyzed by 13C NMR. Our results show a very significant chemical and thermal stabilization of the adsorbed sugar by a silica surface and an almost twofold increase of ribofuranose compared to ribose in solution.
authors.affiliation: Laboratoire de Réactivité de Surface, CNRS UMR-7197, UPMC Univ Paris 06, 3 Rue Galilée, 94200 Ivry sur Seine, France. Electronic address: thomas.georgelin@upmc.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Georgelin
authors.affiliation: Laboratoire de Réactivité de Surface, CNRS UMR-7197, UPMC Univ Paris 06, 3 Rue Galilée, 94200 Ivry sur Seine, France.
authors.forename: Maguy
authors.initials: M
authors.lastname: Jaber
authors.affiliation: Laboratoire de Réactivité de Surface, CNRS UMR-7197, UPMC Univ Paris 06, 3 Rue Galilée, 94200 Ivry sur Seine, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Fournier
authors.affiliation: Laboratoire de Chimie de la Matiere Condensée de Paris, UPMC Univ Paris 06, CNRS UMR 7574, Collège de France, 11 place Marcelin Berthelot, 75005 Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Laurent
authors.affiliation: Laboratoire de Réactivité de Surface, CNRS UMR-7197, UPMC Univ Paris 06, 3 Rue Galilée, 94200 Ivry sur Seine, France.
authors.forename: France
authors.initials: F
authors.lastname: Costa-Torro
authors.affiliation: UMR 7205-ISyEB, CNRS-MNHN-UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Maurel
authors.affiliation: Laboratoire de Réactivité de Surface, CNRS UMR-7197, UPMC Univ Paris 06, 3 Rue Galilée, 94200 Ivry sur Seine, France. Electronic address: jean-francois.lambert@upmc.fr.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Lambert
mesh_terms: D000327:Adsorption; D004355:Drug Stability; D007536:Isomerism; D012266:Ribose / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D012266:Ribose; D012822:Silicon Dioxide
keywords: Mineral surfaces; Prebiotic chemistry; RNA world; Silica; d-Ribose