title: Analysis of the prevalence of dyslipidemia in individuals with HIV and its association with antiretroviral therapy.
abstract: BACKGROUND
  Antiretroviral therapy (ART) has been used to treat large numbers of patients living with human immunodeficiency virus (HIV) infection. Lipid disorders are often observed in these patients, and include elevations in total cholesterol (TC) and triglycerides (TG).
  
  
  METHODS
  A cross-sectional study was performed using 333 patient records from the Regional Hospital of São José Doutor Homero de Miranda Gomes (HRSJHMG). The study population consisted of patients with HIV who were under medical follow up, either on or off drug treatment. The data were entered into Excel and exported to SPSS 16.0 for analysis using chi-square testing. We used prevalence ratios as the measure of association.
  
  
  RESULTS
  Lipid abnormalities were observed in 78.9% of individuals who received ART. Of the 308 subjects on ART, 59.1%, 41.9%, and 33.1% had TG, TC and low-density lipoprotein (LDL) abnormalities, respectively. The prevalence of LDL changes was 2.57-fold higher in individuals who had been using ART for more than 12 months, compared to those using ART for 6 to 12 months.
  
  
  CONCLUSIONS
  HIV patients showed a significant increase in the association between TC and TG levels and the use of ART. In particular, changes in TC, LDL and TG were greater in individuals who had received ART for over more than 12 months.
authors.affiliation: Faculdade de Medicina, Universidade do Sul de Santa Catarina, Palhoça, SC.
authors.forename: Talita Gabriela de
authors.initials: TG
authors.lastname: Limas
authors.affiliation: Departamento de Doenças Infecciosas, Hospital Regional Doutor Homero de Miranda Gomes, São José, SC.
authors.forename: Gustavo de Araujo
authors.initials: Gde A
authors.lastname: Pinto
authors.affiliation: Faculdade de Medicina, Universidade do Sul de Santa Catarina, Palhoça, SC.
authors.forename: Liz Miriane
authors.initials: LM
authors.lastname: Marcato
authors.affiliation: Faculdade de Medicina, Universidade do Sul de Santa Catarina, Palhoça, SC.
authors.forename: Daniel Reszel
authors.initials: DR
authors.lastname: Coelho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D008055:Lipids