title: Urinary Iodine Clearance following Iodinated Contrast Administration: A Comparison of Euthyroid and Postthyroidectomy Subjects.
abstract: Purpose. To compare iodine clearance following iodinated contrast administration in thyroidectomised thyroid cancer patients and euthyroid individuals. Methods. A convenience population (6 thyroidectomised thyroid cancer patients and 7 euthyroid controls) was drawn from patients referred for iodinated contrast-enhanced computed tomography (CT) studies. Subjects had sequential urine samples collected up to 6 months (50 samples from the thyroidectomised and 63 samples from the euthyroid groups). t-tests and generalised estimating equations (GEE) were used to test for group differences in urinary iodine creatinine ratios. Results. Groups had similar urinary iodine creatinine ratios at baseline, with a large increase 2 weeks following iodinated contrast (P = 0.005). Both groups had a return of urinary iodine creatinine ratios to baseline by 4 weeks, with no significant group differences overall or at any time point. Conclusions. Thyroidectomised patients did not have a significantly different urinary iodine clearance than euthyroid individuals following administration of iodinated contrast. Both had a return of urinary iodine creatinine ratios to baseline within 4 weeks.
authors.affiliation: University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
authors.forename: Janice D
authors.initials: JD
authors.lastname: Ho
authors.affiliation: Department of Radiology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
authors.forename: James F
authors.initials: JF
authors.lastname: Tsang
authors.affiliation: Sector Strategies Division, Risk Management Bureau, Safe Environments Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
authors.forename: Kylie A
authors.initials: KA
authors.lastname: Scoggan
authors.affiliation: University of Manitoba, Winnipeg, MB, Canada R3T 2N2 ; Department of Medicine (C5121), 409 Tache Avenue, Winnipeg, MB, Canada R2H 2A6.
authors.forename: William D
authors.initials: WD
authors.lastname: Leslie