title: Systems biology of platelet-vessel wall interactions.
abstract: Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.
authors.affiliation: RH Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Rm 5-220, 303 E. Superior St., 60611, Chicago, IL, USA, yolande-chen@northwestern.edu.
authors.forename: Yolande
authors.initials: Y
authors.lastname: Chen
authors.forename: Seth Joel
authors.initials: SJ
authors.lastname: Corey
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Kim
authors.forename: Mark S
authors.initials: MS
authors.lastname: Alber
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D001808:Blood Vessels / Q000166:cytology / Q000502:physiology*; D002450:Cell Communication; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D049490:Systems Biology