title: [Antioxidant protection of statins in acute kidney injury induced by sepsis].
abstract: OBJECTIVE
  Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis.
  
  
  METHODS
  Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated.
  
  
  RESULTS
  The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality.
  
  
  CONCLUSIONS
  This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.
authors.affiliation: School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Franciele do Nascimento
authors.initials: Fdo N
authors.lastname: Santos
authors.affiliation: School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Mirian
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Carolina Ferreira
authors.initials: CF
authors.lastname: Vasco
authors.affiliation: School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Cassiane Dezoti da
authors.initials: CD
authors.lastname: Fonseca
authors.affiliation: Department of Medical-Surgical Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Maria de Fatima Fernandes
authors.initials: Mde F
authors.lastname: Vattimo
mesh_terms: D058186:Acute Kidney Injury / Q000382:microbiology* / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications*; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin