title: Trigger of autoimmune diseases (SLE): identification of LINE transposition based novel therapeutic molecular targets.
abstract: Autoimmune diseases are the highly heterogeneous at cellular and molecular level. The causes and consequences of most of the autoimmune diseases are not well explored. However the researches focusing on the development of biomarkers for the diagnosis of autoimmune diseases are seems to be inadequate and given treatment are insufficient to control or cure the disease properly. It is a big obstacle to develop any therapy without knowing the actual cause and molecular event playing role in disease onset. In this article we are raising the involvement of LINE or other transposition as a first trigger and cause for autoimmune disease. Further we are proposing a novel hybrid aptamers based biocapturing model which would help in the investigation of genome-wide LINE transposition in pristane induced SLE mice model. Importantly the effect of new LINE movements at the expression pattern of neighboring genes would be used as novel molecular prognostic biomarkers for onset of SLE and related autoimmune diseases. We are also proposing that the differential expression either inductive or suppressive pattern of expected several candidate genes would be implicated in the defective biochemical or cellular defects, and targeted therapy would be employed to such life threatening disease.
authors.affiliation: Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Tiwari
authors.affiliation: Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India. Electronic address: upendrasoni20@gmail.com.
authors.forename: Upendra Kumar
authors.initials: UK
authors.lastname: Soni
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: D052157:Aptamers, Nucleotide; D015415:Biomarkers