title: Association between MTHFR polymorphisms and congenital heart disease: a meta-analysis based on 9,329 cases and 15,076 controls.
abstract: The aim of our study was to evaluate the association between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk for congenital heart disease (CHD). Electronic literature databases were searched to identify eligible studies published before Jun, 2014. The association was assessed by the odds ratio (OR) with a 95% confidence interval (CI). The publication bias was explored using Begg's test. Sensitivity analysis was performed to evaluate the stability of the crude results. A total of 35 studies were included in this meta-analysis. For the MTHFR C677T polymorphism, we detected significant association in all genetic models for Asian children and the maternal population. Significant association was also detected in T vs. C for a Caucasian paediatric population (OR = 1.163, 95% CI: 1.008-1.342) and in both T vs. C (OR = 1.125, 95% CI: 1.043-1.214) and the dominant model (OR = 1.216, 95% CI:b1.096-1.348) for a Caucasian maternal population. For the MTHFR A1298C polymorphism, the association was detected in CC vs. AC for the Caucasian paediatric population (OR = 1.484, 95% CI: 1.035-2.128). Our results support the MTHFR -677T allele as a susceptibility factor for CHD in the Asian maternal population and the -1298 C allele as a risk factor in the Caucasian paediatric population.
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xuan
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Jin-Xia
authors.initials: JX
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Medical Ultrasonics, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Ning
authors.affiliation: The Key Laboratory of Hypertension, The Affiliated Hospital of Qingdao University, Qingdao, P.R China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Graduate School of Medicine, Mie University, Mie, Japan.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.affiliation: 1] TEDA International Cardiovascular Hospital, Tianjin &The Affiliated Hospital of Hangzhou Normal University, Hangzhou, P.R China [2] Department of Surgery, Oregon Health and Science University, Portland, Oregon.
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: He
authors.affiliation: 1] Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, P.R China [2] Medical College of Qingdao University, Qingdao, P.R China.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Lun
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)