title: The non-canonical Hippo/Mst pathway in lymphocyte development and functions.
abstract: The canonical Hippo/Mst pathway, originally discovered in Drosophila, is famous for its function in promoting apoptosis, inhibiting cell proliferation and tumorigenesis, and regulating tissue regeneration. However, emerging evidence shows that multiple non-canonical Hippo signaling pathways are also implicated in the regulation of various other biological processes. Recent studies have revealed that Mst1/2, the core kinases of Hippo/Mst pathway are required for T cell development, function, survival, trafficking, and homing, and also involved in regulation of autoimmunity. In this review, we discuss the roles of non-canonical Hippo/Mst signaling pathways in lymphocyte development and functions.
authors.affiliation: State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Scholl of Life Sciences, Fudan University, Shanghai 200433, China.
authors.forename: Xingrong
authors.initials: X
authors.lastname: Du
authors.affiliation: University of Toronto, Toronto, Ontario M5S2J7, Canada.
authors.forename: Alan
authors.initials: A
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Scholl of Life Sciences, Fudan University, Shanghai 200433, China wufan_tao@fudan.edu.cn.
authors.forename: Wufan
authors.initials: W
authors.lastname: Tao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000276:immunology; D004330:Drosophila; D029721:Drosophila Proteins / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D020930:MAP Kinase Kinase Kinases / Q000276:immunology*; D018448:Models, Immunological; D017346:Protein Serine-Threonine Kinases / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D015533:Transcriptional Activation / Q000276:immunology; D000099317:Hippo Kinases
chemical_list: D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D020930:MAP Kinase Kinase Kinases; D017346:Protein Serine-Threonine Kinases; C105947:mst protein, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases; C093290:MAP3K10 protein, human
keywords: Mst1/2; development; function; lymphocyte