title: Salmonella modulates B cell biology to evade CD8(+) T cell-mediated immune responses.
abstract: Although B cells and antibodies are the central effectors of humoral immunity, B cells can also produce and secrete cytokines and present antigen to helper T cells. The uptake of antigen is mainly mediated by endocytosis; thus, antigens are often presented by MHC-II molecules. However, it is unclear if B cells can present these same antigens via MHC-I molecules. Recently, Salmonella bacteria were found to infect B cells, allowing possible antigen cross-processing that could generate bacterial peptides for antigen presentation via MHC-I molecules. Here, we will discuss available knowledge regarding Salmonella antigen presentation by infected B cell MHC-I molecules and subsequent inhibitory effects on CD8(+) T cells for bacterial evasion of cell-mediated immunity.
authors.affiliation: Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados del IPN , México City, DF , Mexico.
authors.forename: Marcela
authors.initials: M
authors.lastname: Lopez-Medina
authors.affiliation: Department of Microbiology and Molecular Genetics, Irvine School of Medicine, University of California , Irvine, CA , USA.
authors.forename: Araceli
authors.initials: A
authors.lastname: Perez-Lopez
authors.affiliation: Instituto Nacional de Salud Pública, Secretaría de Salud y Asistencia , Cuernavaca, Morelos CP , Mexico.
authors.forename: Celia
authors.initials: C
authors.lastname: Alpuche-Aranda
authors.affiliation: Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados del IPN , México City, DF , Mexico.
authors.forename: Vianney
authors.initials: V
authors.lastname: Ortiz-Navarrete
keywords: B cells; CD8 T cells; PD-L1; Salmonella; cross-presentation