title: [Coexisting systemic lupus erythematosus and sickle cell disease: case report and literature review].
abstract: OBJECTIVE
  To report a case of coexisting systemic lupus erythematosus (SLE) and sickle cell disease (SCD) with a review of the literature on the topic.
  
  
  METHODS
  Report of case and research of the association between SLE and SCD in literature through scientific articles in health sciences databases, such as LILACS, MEDLINE/Pubmed and Scielo, until May 2012. Descriptors used: 1. Sickle cell anemia; 2. Sickle cell disease; 3. Systemic lupus erythematosus; 4. Hemoglobinopathies.
  
  
  RESULTS
  The authors describe an association between SLE and SS hemoglobinopathy in an eight-year-old female patient displaying articular, hematologic and neuropsychiatric manifestations during clinical evolution. Forty-five cases of association between SLE and SCD are described in literature, mostly adult (62.2%), women (78%) and with the SS phenotype in 78% of the cases, and different clinical manifestations. Compared with our patient, articular, hematologic and neuropsychiatric manifestations were present in 76%, 36% and 27% of the cases, respectively.
  
  
  CONCLUSIONS
  SLE and SCD are chronic diseases that have several clinical and laboratory findings in common, meaning difficult diagnosis and difficulty in finding the correct treatment. Although the association between these diseases is not common, it is described in literature, so it is imperative that physicians who treat such diseases be alert to this possibility.
authors.affiliation: Reumatologia pediátrica, Universidade Federal da Bahia, Salvador, BA, Brasil. Electronic address: trobazzi@gmail.com.
authors.forename: Teresa Cristina M V
authors.initials: TC
authors.lastname: Robazzi
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brasil.
authors.forename: Crésio
authors.initials: C
authors.lastname: Alves
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brasil.
authors.forename: Laís
authors.initials: L
authors.lastname: Abreu
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brasil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Lemos
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*
keywords: Anemia falciforme; Doença falciforme; Hemoglobinopathies; Hemoglobinopatias; Lúpus eritematoso sistêmico; Sickle cell anemia; Sickle cell disease; Systemic lupus erythematosus