title: High-efficient synthesis and biological activities of allosamidins.
abstract: The pseudo-trisaccharide allosamidin 1 is a potent inhibitor of all family-18 chitinases, and it is confirmed to have insecticidal and antifungal activities. But the synthesis of allosamidins is very difficult, and it is a challengeable subject. Allosamidins were synthesized in solid-liquid phase, total solid-phase and total liquid-phase, respectively. Solid-liquid phase method realizes the partial solid-phase synthesis of allosamidins. Total solid-phase method greatly simplifies the purification process. Total liquid-phase method shortens the synthetic steps of allosamidins. The insecticidal and antifungal activities of allosamidins were also reported herein.
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Gangliang
authors.initials: G
authors.lastname: Huang
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Daquan
authors.initials: D
authors.lastname: Peng
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Xinya
authors.initials: X
authors.lastname: Mei
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xiao
authors.affiliation: a College of Chemistry, Chongqing Normal University , Chongqing , China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Tang
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012831:Bombyx / Q000187:drug effects; D002236:Carbohydrate Conformation; D002688:Chitinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018411:Spodoptera / Q000187:drug effects; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D007306:Insecticides; D014312:Trisaccharides; C054851:allosamidin; D002688:Chitinases; D000117:Acetylglucosamine
keywords: Allosamidins; chitinase inhibitory activities; insecticidal and antifungal activities; synthesis