title: Methods and challenges in quantitative imaging biomarker development.
abstract: Academic radiology is poised to play an important role in the development and implementation of quantitative imaging (QI) tools. This article, drafted by the Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force, reviews current issues in QI biomarker research. We discuss motivations for advancing QI, define key terms, present a framework for QI biomarker research, and outline challenges in QI biomarker development. We conclude by describing where QI research and development is currently taking place and discussing the paramount role of academic radiology in this rapidly evolving field.
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, CCC-1121 MCN, Nashville, TN 37232-2675. Electronic address: richard.abramson@vanderbilt.edu.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Abramson
authors.affiliation: Department of Medical Imaging and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kirsteen R
authors.initials: KR
authors.lastname: Burton
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, California.
authors.forename: John-Paul J
authors.initials: JP
authors.lastname: Yu
authors.affiliation: Department of Radiology, SUNY Upstate Medical University, Syracuse New York.
authors.forename: Ernest M
authors.initials: EM
authors.lastname: Scalzetti
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Yankeelov
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, New York.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Rosenkrantz
authors.affiliation: Abdominal and Cross-Sectional Interventional Radiology, Henry Ford Hospital, Detroit, Michigan.
authors.forename: Mishal
authors.initials: M
authors.lastname: Mendiratta-Lala
authors.affiliation: Division of Radiology Informatics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bartholmai
authors.affiliation: Department of Abdominal Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Dhakshinamoorthy
authors.initials: D
authors.lastname: Ganeshan
authors.affiliation: Department of Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.
authors.forename: Leon
authors.initials: L
authors.lastname: Lenchik
authors.affiliation: Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Rathan M
authors.initials: RM
authors.lastname: Subramaniam
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D015336:Molecular Probe Techniques; D015335:Molecular Probes
chemical_list: D015415:Biomarkers; D015335:Molecular Probes
keywords: Radiology; biomarker development; quantitative imaging