title: Combined perfusion and doppler imaging using plane-wave nonlinear detection and microbubble contrast agents.
abstract: Plane-wave imaging offers image acquisition rates at the pulse repetition frequency, effectively increasing the imaging frame rates by up to two orders of magnitude over conventional line-by-line imaging. This form of acquisition can be used to achieve very long ensemble lengths in nonlinear modes such as pulse inversion Doppler, which enables new imaging trade-offs that were previously unattainable. We first demonstrate in this paper that the coherence of microbubble signals under repeated exposure to acoustic pulses of low mechanical index can be as high as 204 ± 5 pulses, which is long enough to allow an accurate power Doppler measurement. We then show that external factors, such as tissue acceleration, restrict the detection of perfusion at the capillary level with linear Doppler, even if long Doppler ensembles are considered. Hence, perfusion at the capillary level can only be detected with ultrasound through combined microbubbles and Doppler imaging. Finally, plane-wave contrast-enhanced power and color Doppler are performed on a rabbit kidney in vivo as a proof of principle. We establish that long pulse-inversion Doppler sequences and conventional wall-filters can create an image that simultaneously resolves both the vascular morphology of veins and arteries, and perfusion at the capillary level with frame rates above 100 Hz.
authors.forename: Charles
authors.initials: C
authors.lastname: Tremblay-Darveau
authors.forename: Ross
authors.initials: R
authors.lastname: Williams
authors.forename: Laurent
authors.initials: L
authors.lastname: Milot
authors.forename: Matthew
authors.initials: M
authors.lastname: Bruce
authors.forename: Peter N
authors.initials: PN
authors.lastname: Burns
mesh_terms: D000818:Animals; D003287:Contrast Media; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000000981:diagnostic imaging; D045423:Microbubbles; D017711:Nonlinear Dynamics; D010477:Perfusion / Q000379:methods*; D019047:Phantoms, Imaging; D011817:Rabbits; D018608:Ultrasonography, Doppler / Q000379:methods*
chemical_list: D003287:Contrast Media