title: Synthesis of attapulgite/N-isopropylacrylamide and its use in drug release.
abstract: Environmentally sensitive hydrogels as one of the most potential drug delivery systems have gained considerable interest in recent years. In the present study, we synthesized a newly temperature-responsive composite hydrogel based on attapulgite (ATP) and poly (N-isopropylacrylamide) (PNIPAM) as the localized drug carriers for drug delivery. The as-prepared ATP/PNIPAM hydrogel has large aperture which significantly improved the quantity of adsorption of drugs, exhibiting the excellent properties of drug release. The scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and X-ray diffraction (XRD) were used to characterize the ATP/PNIPAM. The swelling/deswelling behaviors and the release of ciprofloxacin lactate were studied. When the temperature was below the low critical solution temperature (LCST), the swelling property of hydrogels was excellent and the swelling rate was large. And, the drug release rate increased with the increase of the content of attapulgite in the composite hydrogel when it was put in the buffer solution (pH7.38) at 37.0°C. Therefore, the composite hydrogels might be very useful for its application in biomedical fields.
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China; Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, PR China.
authors.forename: Xiaomo
authors.initials: X
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China; Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, PR China. Electronic address: huizhong@hytc.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhong
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China. Electronic address: lxr206206@163.com.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China; Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, PR China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Jia
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China.
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Yin
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China.
authors.forename: Litao
authors.initials: L
authors.lastname: An
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun 130024, Jilin, PR China. Electronic address: guolp078@nenu.edu.cn.
authors.forename: Liping
authors.initials: L
authors.lastname: Guo
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D002939:Ciprofloxacin / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis*; D065546:Drug Liberation; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017616:Magnesium Compounds / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D017655:Silicon Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D017616:Magnesium Compounds; D017655:Silicon Compounds; C052970:poly-N-isopropylacrylamide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002939:Ciprofloxacin; C026325:attapulgite
keywords: Attapulgite; Ciprofloxacin lactate; Drug delivery system; N-isopropylacrylamide