title: Acid-sensing ion channels: trafficking and pathophysiology.
abstract: Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis. Although much progress has been made in researching the structure-function relationship and pharmacology of ASICs, little is known about the trafficking of ASICs and its contribution to ASIC function. The recent identification of the mechanism of membrane insertion and endocytosis of ASIC1a highlights the emerging role of ASIC trafficking in regulating its pathophysiological functions. In this review, we summarize the recent advances and discuss future directions on this topic.
authors.affiliation: a Discipline of Neuroscience and Department of Anatomy; Histology and Embryology; Institute of Medical Sciences ; Shanghai Jiao Tong University School of Medicine ; Shanghai 200025 , P.R. China.
authors.forename: Wei-Zheng
authors.initials: WZ
authors.lastname: Zeng
authors.forename: Di-Shi
authors.initials: DS
authors.lastname: Liu
authors.forename: Tian-Le
authors.initials: TL
authors.lastname: Xu
mesh_terms: D062565:Acid Sensing Ion Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D005089:Exocytosis; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D021382:Protein Sorting Signals; D021381:Protein Transport
chemical_list: D062565:Acid Sensing Ion Channels; D021382:Protein Sorting Signals
keywords: accessory proteins; acid-sensing ion channels; motifs; signaling pathways; surface expression; trafficking