title: Animal models of scoliosis.
abstract: Multiple techniques designed to induce scoliotic deformity have been applied across many animal species. We have undertaken a review of the literature regarding experimental models of scoliosis in animals to discuss their utility in comprehending disease aetiology and treatment. Models of scoliosis in animals can be broadly divided into quadrupedal and bipedal experiments. Quadrupedal models, in the absence of axial gravitation force, depend upon development of a mechanical asymmetry along the spine to initiate a scoliotic deformity. Bipedal models more accurately mimic human posture and consequently are subject to similar forces due to gravity, which have been long appreciated to be a contributing factor to the development of scoliosis. Many effective models of scoliosis in smaller animals have not been successfully translated to primates and humans. Though these models may not clarify the aetiology of human scoliosis, by providing a reliable and reproducible deformity in the spine they are a useful means with which to test interventions designed to correct and prevent deformity.
authors.affiliation: Orthopaedic Research & Biotechnology Unit, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia.
authors.forename: Justin D
authors.initials: JD
authors.lastname: Bobyn
authors.forename: David G
authors.initials: DG
authors.lastname: Little
authors.forename: Randolph
authors.initials: R
authors.lastname: Gray
authors.forename: Aaron
authors.initials: A
authors.lastname: Schindeler
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002417:Cattle; D002645:Chickens; D004195:Disease Models, Animal; D005399:Fishes; D006041:Goats; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D011817:Rabbits; D012600:Scoliosis / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery; D013123:Spinal Fusion / Q000379:methods; D013552:Swine; D016474:Weight-Bearing
keywords: animal model; scoliosis; spine; spine fusion