title: The end of Nef's tether.
abstract: Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.
authors.affiliation: Department of Biological Sciences, College of Arts and Sciences, Texas Tech University, 8(th) and Canton Avenue, Lubbock, TX 79409-3131, USA. Electronic address: ruth.serra-moreno@ttu.edu.
authors.forename: Ruth
authors.initials: R
authors.lastname: Serra-Moreno
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D054311:nef Gene Products, Human Immunodeficiency Virus
keywords: HIV; Nef; restriction; tetherin