title: Bronchoscopic intervention as a main treatment for tracheobronchial adenoid cystic carcinoma.
abstract: BACKGROUND
  Bronchial adenoid cystic carcinoma (ACC) is a rare disease with low malignancy and indolent progression. Airway obstruction caused by ACC can be resolved by endoscopic procedures. The efficacy of different techniques of bronchoscopic interventions for ACC has not been determined.
  
  
  METHODS
  From November 2004 to March 2012, ACC patients, mainly treated with different techniques of bronchoscopic interventions in our hospital, were reviewed.
  
  
  RESULTS
  The study included 37 ACC patients. Five patients (13.5%) with intra-luminal type underwent bronchoscopic therapies for a median of three times (range 1-6 times). Thirty-two patients (86.5%) with mixed type underwent bronchoscopic interventions for a median of 14 times (range 4-20 times). The dyspnea index was significantly improved after the first endoscopic procedure. The overall five- and ten-year survival rate was 85.9% and 45.9%, respectively, similar to surgery-dominant treatments.
  
  
  CONCLUSIONS
  The present study demonstrates that different procedures of bronchoscopic interventions, as main treatments for ACC, are as effective as surgery-dominant treatment. More prospective and multicentric studies are required to confirm these favorable results, which may influence the therapeutic strategy for ACC in the future.
authors.affiliation: Department of Medical Oncology, China Meitan General Hospital , Beijing , China.
authors.forename: Hongwu
authors.initials: H
authors.lastname: Wang
authors.forename: Jieli
authors.initials: J
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Li
authors.forename: Heng
authors.initials: H
authors.lastname: Zou
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Sujuan
authors.initials: S
authors.lastname: Liang
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: Mao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001984:Bronchial Neoplasms / Q000628:therapy*; D001999:Bronchoscopy / Q000295:instrumentation* / Q000379:methods*; D003528:Carcinoma, Adenoid Cystic / Q000628:therapy*; D004417:Dyspnea; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors; D016019:Survival Analysis
keywords: Adenoid cystic carcinoma (ACC); bronchoscopic therapy; survival