title: Ten years cardiovascular risk estimation according to Framingham score and non HDL-cholesterol in blood donors.
abstract: Cardiovascular disease (CVD) is currently the primary cause of morbidity and mortality.
  
  
  OBJECTIVE
  (1) Assess the 10 years risk for CVD in Argentinean blood donors, according to Framingham score (updated by ATP III), (2) evaluate the prevalence of the MS, (3) evaluate non HDL-cholesterol level in this population as other risk for CVD.
  
  
  METHODS
  A prospective, epidemiological, transversal study was performed to evaluate 585 volunteer blood donors for two years. Non HDL-C was calculated as total cholesterol minus HDL-C and we evaluated the 10 years risk for CVD according to Framingham score (updated by ATP III).
  
  
  RESULTS
  Metabolic syndrome prevalence was estimated according to ATP III and IDF criteria. Non HDL-C was (media±SD) 178.3±48.0 mg/dl in participants with MS and 143.7±39.3 mg/dl without MS (ATPIII) and 160.1±43.6 mg/dl in participants with MS and 139.8±43.1 mg/dl without MS (IDF). Participants with MS presented an OR of 3.1; IC 95% (2-5) of CVD according to de Framingham score.
  
  
  CONCLUSIONS
  Individuals with MS and elevated non HDL-C are at a higher estimated risk for cardiovascular events in the next 10 years according to the Framingham risk score.
authors.affiliation: Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina; Endocrinology Division, Carlos Durand Hospital, Buenos Aires, Argentina. Electronic address: mgraffigna@gmail.com.ar.
authors.forename: Mabel Nora
authors.initials: MN
authors.lastname: Graffigna
authors.affiliation: Clinical Biochemistry Department, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Electronic address: gaberg@ffyb.uba.ar.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Berg
authors.affiliation: Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina. Electronic address: memigliano@yahoo.com.ar.
authors.forename: Marta
authors.initials: M
authors.lastname: Migliano
authors.affiliation: Bachelor of Science in Biology, Centre for Population Health Research. Durand Hospital, Buenos Aires, Argentina. Electronic address: psalgado@fibertel.com.ar.
authors.forename: Pablo
authors.initials: P
authors.lastname: Salgado
authors.affiliation: Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina; Endocrinology Service, Churruca-Visca Hospital, Argentina. Electronic address: jimesoutelo@arnet.com.ar.
authors.forename: Jimena
authors.initials: J
authors.lastname: Soutelo
authors.affiliation: Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina; Endocrinology and Metabolism Unit, Dr. C Milstein Hospital, Buenos Aires, Argentina. Electronic address: mussocar@hotmail.com.
authors.forename: Carla
authors.initials: C
authors.lastname: Musso
mesh_terms: D000328:Adult; D017677:Age Distribution; D001118:Argentina / Q000453:epidemiology; D001782:Blood Donors / Q000706:statistics & numerical data*; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D002784:Cholesterol
keywords: Cardiovascular disease; Framingham score; Metabolic syndrome; Non HDL-cholesterol