title: Atenolol prevents the formation of expansive hematoma after rhytidoplasty.
abstract: OBJECTIVE
  To evaluate the perioperative use of atenolol in reducing the incidence of hematoma after rhytidoplasty.
  
  
  METHODS
  Between January 2007 and February 2013, 80 patients were randomized into two groups: Group A (n = 26) received perioperative atenolol in order to maintain heart rate (PR) around 60 per minute; Group B (n = 54) did not receive atenolol. Both groups underwent the same anesthetic and surgical technique. We monitored blood pressure (BP), HR, hematoma formation and the need for drainage. Patients were followed-up until the 90th postoperative day. The variables were compared between the groups using the ANOVA test. Continuous variables were presented as mean ± standard deviation and the differences were compared with the Student's t test. Values of p d" 0.05 were considered significant.
  
  
  RESULTS
  In group A the mean BP (110-70 mm Hg ± 7.07) and HR (64 / min ± 5) were lower (p d" 0.05) than in group B (135-90 mm Hg ± 10.6) and (76 / min ± 7.5), respectively. There were four cases of expansive hematoma in group B, all requiring reoperation for drainage, and none in group A (p d" 0,001).
  
  
  CONCLUSIONS
  The perioperative use of atenolol caused a decrease in blood pressure and heart rate and decreased the incidence of expanding hematoma after rhytidectomy.
authors.affiliation: Western São Paulo University.
authors.forename: Amanda Castilho
authors.initials: AC
authors.lastname: Moreira
authors.affiliation: Ingá Faculty.
authors.forename: Marcio
authors.initials: M
authors.lastname: Moreira
authors.affiliation: Ingá Faculty.
authors.forename: Sanderland José Tavares
authors.initials: SJ
authors.lastname: Gurgel
authors.affiliation: Ingá Faculty.
authors.forename: Yasmin Castilho
authors.initials: YC
authors.lastname: Moreira
authors.affiliation: Ingá Faculty.
authors.forename: Eguimar Roberto
authors.initials: ER
authors.lastname: Martins
authors.affiliation: Ingá Faculty.
authors.forename: Raphael Chalbaud Biscaia
authors.initials: RC
authors.lastname: Hartmann
authors.affiliation: Paulista School of Medicine, Federal University of São Paulo.
authors.forename: Djalma José
authors.initials: DJ
authors.lastname: Fagundes
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D005260:Female; D006406:Hematoma / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control*; D011446:Prospective Studies; D015361:Rhytidoplasty / Q000009:adverse effects*
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D001262:Atenolol