title: Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid.
abstract: In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers.
authors.affiliation: Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice, Poland. Electronic address: monika.smiga-matuszowicz@polsl.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Smiga-Matuszowicz
authors.affiliation: Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Janicki
authors.affiliation: Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jaszcz
authors.affiliation: Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody Street 9, 44-100 Gliwice, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Łukaszczyk
authors.affiliation: Silesian University of Technology, Department of Biomaterials and Medical Devices Engineering, de Gaulle'a Street 66, 41-800 Zabrze, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kaczmarek
authors.affiliation: Medical University of Silesia, Department of General and Molecular Biology and Genetics, Medyków Street 18, 40-752 Katowice, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Lesiak
authors.affiliation: Medical University of Silesia, Department of General and Molecular Biology and Genetics, Medyków Street 18, 40-752 Katowice, Poland.
authors.forename: Aleksander L
authors.initials: AL
authors.lastname: Sieroń
authors.affiliation: Silesian University of Technology, Department of Chemistry, Inorganic Technology and Fuels, B. Krzywoustego Street 6, 44-100 Gliwice, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Simka
authors.affiliation: Medical University of Silesia, Department of Orthopedics and Traumatology, Ziołowa Street 45, 40-635 Katowice, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Mierzwiński
authors.affiliation: Medical University of Silesia, Department of Orthopedics and Traumatology, Ziołowa Street 45, 40-635 Katowice, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Kusz
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry; D055119:Elastic Modulus; D006801:Humans; D007547:Isosorbide / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D012117:Resins, Synthetic / Q000737:chemistry* / Q000633:toxicity; D013052:Spectrometry, X-Ray Emission; D019802:Succinic Acid / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D012117:Resins, Synthetic; D017886:Durapatite; D019802:Succinic Acid; D007547:Isosorbide
keywords: Biobased oligoesters; Isosorbide; Orthopedic biomaterials; Polymeric scaffolds