title: Small RNAs meet their targets: when methylation defends miRNAs from uridylation.
abstract: Small RNAs are incorporated into Argonaute protein-containing complexes to guide the silencing of target RNAs in both animals and plants. The abundance of endogenous small RNAs is precisely controlled at multiple levels including transcription, processing and Argonaute loading. In addition to these processes, 3' end modification of small RNAs, the topic of a research area that has rapidly evolved over the last several years, adds another layer of regulation of their abundance, diversity and function. Here, we review our recent understanding of small RNA 3' end methylation and tailing.
authors.affiliation: a State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development; Institute of Plant Biology; School of Life Sciences; Fudan University ; Shanghai , China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Ren
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D060565:Argonaute Proteins / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D035683:MicroRNAs / Q000378:metabolism*; D026721:RNA 3' End Processing / Q000502:physiology; D034741:RNA, Small Interfering / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism*
chemical_list: D060565:Argonaute Proteins; D035683:MicroRNAs; D034741:RNA, Small Interfering; D014529:Uridine
keywords: argonaute; methylation; small RNA; uridylation