title: MSP: an emerging player in metabolic syndrome.
abstract: MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R). Since its discovery, MSP has been demonstrated to play a key role in regulating inflammation in the peripheral tissues of multiple disease models. Recent evidences also point toward a beneficial role of MSP in the regulation of hepatic lipid and glucose metabolism, thereby implicating MSP as a crucial regulator in maintaining metabolic homeostasis while simultaneously suppressing inflammatory processes. In this review, we discuss the recent advances that demonstrate the significance of MSP in metabolic syndrome and build a strong case supporting its therapeutic potential.
authors.affiliation: Department of Molecular Genetics, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
authors.forename: Jieyi
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands. Electronic address: d.chanda@maastrichtuniversity.nl.
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Chanda
authors.affiliation: Department of Molecular Genetics, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
authors.forename: Ronit
authors.initials: R
authors.lastname: Shiri-Sverdlov
authors.affiliation: Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
authors.forename: Dietbert
authors.initials: D
authors.lastname: Neumann
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D017228:Hepatocyte Growth Factor / Q000502:physiology* / Q000627:therapeutic use*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000502:physiology* / Q000627:therapeutic use*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011518:Proto-Oncogene Proteins; C082332:macrophage stimulating protein; D017228:Hepatocyte Growth Factor; D020794:Receptor Protein-Tyrosine Kinases
keywords: Inflammation; MSP; Metabolic syndrome; RON