title: Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.
abstract: Gastric cancer occurs almost exclusively in patients with gastritis. Since Helicobacter pylori (Hp) was proved to cause gastritis, Hp was also expected to play a role in gastric carcinogenesis. Despite extensive studies, the mechanisms by which Hp cause gastric cancer are still poorly understood. However, there is evidence that the anatomical site of Hp infection is of major importance. Infection confined to the antral mucosa protects against gastric cancer but predisposes to duodenal ulcer, whereas Hp infection of the oxyntic mucosa increases the risk of gastric cancer. Hp infection does not predispose to cancers in the gastric cardia. In patients with atrophic gastritis of the oxyntic mucosa, the intragastric pH is elevated and the concentration of microorganisms in the stomach is increased. This does not lead to increased risk of gastric cancer at all anatomical sites. The site specificity of Hp infection in relation to cancer risk indicates that neither Hp nor the changes in gastric microflora due to gastric hypoacidity are carcinogenic per se. However, reduced gastric acidity also leads to hypergastrinemia, which stimulates the function and proliferation of enterochromaffin-like (ECL) cells located in the oxyntic mucosa. The ECL cell may be more important in human gastric carcinogenesis than previously realized, as every condition causing long-term hypergastrinemia in animals results in the development of neoplasia in the oxyntic mucosa. Patients with hypergastrinemia will far more often develop carcinomas in the gastric corpus. In conclusion, hypergastrinemia may explain the carcinogenic effect of Hp.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Prinsesse Kristinas Gate 1, 7006, Trondheim, Norway, helge.waldum@ntnu.no.
authors.forename: Helge L
authors.initials: HL
authors.lastname: Waldum
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Hauso
authors.forename: Øystein F
authors.initials: ØF
authors.lastname: Sørdal
authors.forename: Reidar
authors.initials: R
authors.lastname: Fossmark
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000502:physiology*; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012306:Risk; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D005755:Gastrins