title: A model of ionic transport and osmotic volume control in cochlear outer hair cells.
abstract: A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membrane of OHCs. A model of intracellular pH transients following the imposition of a rapid acid load upon the cell has been adapted from the squid axon literature and further extended in order to investigate the effects of ion transport upon the osmotic flux of water into the cell. The model predicts the slow length changes of OHCs reported in the literature a feature which may control the contribution of OHCs to cochlear amplification.
authors.affiliation: UCL Ear Institute , 332 Gray's Inn Road, London WC1X 8EE , UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: West
authors.affiliation: UCL Ear Institute , 332 Gray's Inn Road, London WC1X 8EE , UK ; Department of Neuroscience, Physiology and Pharmacology , UCL , Gower St., London WC1E 6BT , UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ashmore
keywords: cochlea, hair cell; ion flux; model; motility