title: Inhibition of priming for bovine respiratory syncytial virus-specific protective immune responses following parenteral vaccination of passively immune calves.
abstract: The effect of maternal antibodies (MatAb) on immunological priming by neonatal parenteral vaccination for bovine respiratory syncytial virus (BRSV) was addressed for the first time in experimental infection in 34 Holstein calves. Both vaccinated and control calves developed moderate to severe respiratory disease characteristic of acute BRSV infection. There were no differences in clinical signs, BRSV shed, arterial oxygen concentrations, or mortality between vaccinated and control calves after BRSV challenge approximately 11 wk after vaccination. There were no anamnestic antibody or cytokine responses in the vaccinates after challenge. Lung lesions were extensive in both groups, and although there was a statistically significant (P = 0.05) difference between groups, this difference was considered not biologically significant. These data indicate that stimulation of protective immune responses was inhibited by maternal antibodies when a combination modified-live BRSV vaccine was administered parenterally to young passively immune calves. Alternate routes of administration or different vaccine formulations should be used to successfully immunize young calves with good passive antibody transfer.
authors.affiliation: The Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
authors.forename: John
authors.initials: J
authors.lastname: Ellis
authors.affiliation: The Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
authors.forename: Sheryl
authors.initials: S
authors.lastname: Gow
authors.affiliation: The Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
authors.forename: Michael
authors.initials: M
authors.lastname: Bolton
authors.affiliation: The Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
authors.forename: William
authors.initials: W
authors.lastname: Burdett
authors.affiliation: The Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
authors.forename: Scott
authors.initials: S
authors.lastname: Nordstrom
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002417:Cattle / Q000276:immunology / Q000821:virology; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D016207:Cytokines / Q000097:blood; D007116:Immunization, Passive / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D014765:Viral Vaccines