title: Clinical outcome of renal artery stenting for hypertension and chronic kidney disease up to 12 months in the J-RAS Study – prospective, single-arm, multicenter clinical study.
abstract: BACKGROUND
  Atherosclerotic renal artery stenosis (ARAS) causes renovascular hypertension (HTN) and impairs renal function, leading to chronic kidney disease (CKD). The J-RAS study was a prospective, multicenter study to assess the clinical outcome of renal artery stenting for up to 1 year in Japanese patients with ARAS.
  
  
  RESULTS
  One hundred and forty-nine patients were enrolled between November 2010 and January 2013. The patients were classified into an HTN (n=121) group and a CKD (n=108) group in the primary analysis. The primary efficacy endpoints were change in blood pressure for the HTN group and change in estimated glomerular filtration rate (eGFR) for the CKD group at 1 months. The primary safety endpoint was freedom from major cardiovascular or renal events at 12 months. In the HTN group, the mean systolic blood pressure (SBP) significantly decreased from 161.6 ± 21 mmHg at baseline to 137.0 ± 21 mmHg (P<0.0001). In the CKD group, there was no significant difference in eGFR from 40.7 ± 10 ml·min(-1)·1.73 m(-2)at baseline to 40.8 ± 13 ml·min(-1)·1.73 m(-2)(P=0.32). The primary safety endpoint was 89.4% at 12 months.
  
  
  CONCLUSIONS
  In the J-RAS trial, significant SBP reduction was seen in the HTN group, and stabilization of renal function in the CKD group. Renal artery stenting for ARAS is safe and effective in Japanese patients.
authors.affiliation: Kishiwada Tokushukai Hospital Cardiovascular Center, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Fujihara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yokoi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Abe
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Soga
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyashita
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yokoi
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D050197:Atherosclerosis / Q000503:physiopathology / Q000601:surgery; D001794:Blood Pressure; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000601:surgery; D007564:Japan; D008875:Middle Aged; D011446:Prospective Studies; D012077:Renal Artery / Q000503:physiopathology / Q000601:surgery; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology / Q000601:surgery; D015607:Stents