title: Sleeping beauty wakes up the clonal succession model for homeostatic hematopoiesis.
abstract: Recently in Nature, Sun et al. (2014) used a sleeping beauty transposon system to demonstrate that natural hematopoiesis is sustained by the successive recruitment of thousands of clones that are mostly lineage restricted. These findings call into question whether homeostatic hematopoiesis is sustained by hematopoietic stem cells traditionally identified by transplantation.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, 1425 San Pablo Street, Los Angeles, CA 90033, USA. Electronic address: ronglu@usc.edu.
authors.forename: Rong
authors.initials: R
authors.lastname: Lu
mesh_terms: D000818:Animals; D019070:Cell Lineage; D002999:Clone Cells / Q000166:cytology*; D005260:Female; D006410:Hematopoiesis; D008297:Male