title: Prognostic factors for long-term poor outcomes after acute ischemic stroke in very old age (>80 years) patients: Total cholesterol level might differently influence long-term outcomes after acute ischemic stroke at ages above 80 years.
abstract: OBJECTIVE
  We investigated the differences in determinant factors for functional outcomes between patients aged >80 years and those aged <80 years after acute ischemic stroke (AIS). In particular, we would like to know the differential impacts of initial total cholesterol (TC) levels between the two groups.
  
  
  METHODS
  We defined a poor outcome as 3-6 modified Rankin Scale 90 days after AIS.
  
  
  RESULTS
  In the present study, 2772 participants were enrolled. Among them, 374 patients (13.5%) were aged >80 years, and 1061 patients had a poor outcome 90 days after AIS. The proportion was significantly higher in patients aged >80 years than in those aged <80 years after AIS. Regarding factors relating to poor outcomes, previous history of stroke, stroke severity and stroke subtypes of ischemic stroke were independent factors in patients aged <80 years, and the stroke severity and initial TC level independently influenced the outcome for patients aged >80 years. In particular, risk of poor outcome adjusted for age, stroke severity and subtypes of ischemic stroke for patients (OR [95% CI]) in the first quartile range (≤157 mg%) were 2.21 (1.06-4.62), in the third quartile range (184-210 mg%) 2.76 (1.27-6.01) and in the fourth quartile range (≥211 mg%) 2.75 (1.21-6.24) compared with those in the second quartile range (158-183 mg%) in patients aged >80 years.
  
  
  CONCLUSIONS
  There were also some differences in related factors regarding occurrences of poor outcome between the two groups. In particular, the initial TC level might play a crucial role for the outcome after AIS in the very old population.
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Cha
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Nah
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Hyun-Seok
authors.initials: HS
authors.lastname: Park
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Visual Optics, KyungWoon University, Gumi, Korea.
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Suh
authors.affiliation: Stroke Center, Dong-A University Hospital, Busan, Korea.
authors.forename: Jae-Taeck
authors.initials: JT
authors.lastname: Huh
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000401:mortality* / Q000628:therapy; D002423:Cause of Death; D002784:Cholesterol / Q000097:blood*; D016208:Databases, Factual; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood / Q000401:mortality* / Q000628:therapy; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D002784:Cholesterol
keywords: cholesterol; old ages; outcomes; risk factors; stroke