title: Quantitative and qualitative comparison of 0.025 mmol/kg gadobenate dimeglumine for abdominal MRI at 1.5T and 3T MRI in patients with low estimated glomerular filtration rate.
abstract: OBJECTIVE
  To investigate the efficacy and adequacy of enhancement employing 0.025 mmol/kg of gadobenate dimeglumine at 1.5 Tesla (T), and to compare the extent of enhancement of this dosage between 1.5T and 3T systems.
  
  
  METHODS
  Our final population included 116 consecutive patients who underwent 0.025 mmol/kg gadobenate dimeglumine-enhanced abdominal MRI (78 men and 38 women; age, 64.1 ± 13.6 years). Sixty patients underwent imaging at 1.5T and 56 patients underwent imaging at 3T. Abdominal enhancement was evaluated qualitatively and quantitatively. The quality of enhancement was compared using Mann-Whitney U test. The percentage of enhancement of each organ was compared using Student t-test.
  
  
  RESULTS
  The mean quality rating of enhancement was at least "good" in all phases of enhancement for both 1.5T and 3T. There was a non-significant trend to higher mean ratings at 3T. The liver showed a 1.3-fold higher arterial-phase percentage of enhancement at 3T (p=0.0138). There were no differences between the mean relative enhancement of the pancreas and aorta throughout all phases of enhancement. The percentage of enhancement of the renal cortex was significantly higher at 3T (p<0.0001 to p=0.0293).
  
  
  CONCLUSIONS
  A dose of 0.025 mmol/kg of gadobenate dimeglumine demonstrates diagnostic enhancement in the majority of patients at 1.5T, without significant differences on qualitative evaluation compared to 3T.
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ramalho
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Mamdoh
authors.initials: M
authors.lastname: AlObaidy
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Busireddy
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Ersan
authors.initials: E
authors.lastname: Altun
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Baodong
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Radiology, University Of North Carolina At Chapel Hill, Chapel Hill, NC, USA. Electronic address: richsem@med.unc.edu.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Semelka
mesh_terms: D000005:Abdomen / Q000473:pathology; D000328:Adult; D003287:Contrast Media / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007668:Kidney / Q000378:metabolism*; D008107:Liver Diseases / Q000175:diagnosis* / Q000473:pathology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000378:metabolism; D008875:Middle Aged; D009942:Organometallic Compounds / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000473:pathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
keywords: 0.025mmol/kg; 1.5T; Dynamic imaging; Gadobenate dimeglumine; Nephrogenic systemic fibrosis; Quarter dose