title: Adaptive settings for the nearest-neighbor particle tracking algorithm.
abstract: BACKGROUND
  The performance of the single particle tracking (SPT) nearest-neighbor algorithm is determined by parameters that need to be set according to the characteristics of the time series under study. Inhomogeneous systems, where these characteristics fluctuate spatially, are poorly tracked when parameters are set globally.
  
  
  RESULTS
  We present a novel SPT approach that adapts the well-known nearest-neighbor tracking algorithm to the local density of particles to overcome the problems of inhomogeneity.
  
  
  CONCLUSIONS
  We demonstrate the performance improvement provided by the proposed method using numerical simulations and experimental data and compare its performance with state of the art SPT algorithms.
  
  
  METHODS
  The algorithms proposed here, are released under the GNU General Public License and are freely available on the web at http://sourceforge.net/p/adaptivespt.
  
  
  BACKGROUND
  javier.mazzaferri@gmail.com
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4.
authors.forename: Javier
authors.initials: J
authors.lastname: Mazzaferri
authors.affiliation: Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4.
authors.forename: Joannie
authors.initials: J
authors.lastname: Roy
authors.affiliation: Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4 Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4.
authors.forename: Stephane
authors.initials: S
authors.lastname: Lefrancois
authors.affiliation: Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4 Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada H1T 2M4, Département de Médecine, Université de Montréal, Montréal, Canada H3T 3J7 and Département d'Ophtalmologie et Institut de Génie Biomédical, Université de Montréal, Montréal, Canada H3T 1J4.
authors.forename: Santiago
authors.initials: S
authors.lastname: Costantino
mesh_terms: D000465:Algorithms; D002465:Cell Movement; D058948:Cell Tracking; D016000:Cluster Analysis; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D009504:Neutrophils / Q000166:cytology* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes