title: Evaluation of efficacy of skin cleansing with chlorhexidine in prevention of neonatal nosocomial sepsis - a randomized controlled trial.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of skin cleansing with chlorhexidine (CHD) in the prevention of neonatal nosocomial sepsis - a randomized controlled trial.
  
  
  METHODS
  This study design was a randomized controlled trial carried out in a tertiary care center of north India. About 140 eligible neonates were randomly allocated to either the subject area group (wiped with CHD solution till day seven of life) or the control group (wiped with lukewarm water). The primary outcome studied was to determine the decrease in the incidence of neonatal nosocomial sepsis (blood culture proven) in the intervention group.
  
  
  RESULTS
  Out of 140 enrolled neonates, 70 were allocated to each group. The ratio of positive blood culture among the CHD group was 3.57%, while the ratio of positive blood culture among the control group was 6.85%. There was trending towards a reduction in blood culture proven sepsis in the intervention group, although the remainder was not statistically significant. A similar decreasing trend was observed in rates of skin colonization, duration of hospital stay, and duration of antibiotic treatment.
  
  
  CONCLUSIONS
  CHD skin cleansing decreases the incidence of blood culture sepsis and could be an easy and cheap intervention for reducing the neonatal sepsis in countries where the neonatal mortality rate is high because of sepsis.
authors.affiliation: a Department of Paediatrics .
authors.forename: Basudev
authors.initials: B
authors.lastname: Gupta
authors.affiliation: a Department of Paediatrics .
authors.forename: Narain Das
authors.initials: ND
authors.lastname: Vaswani
authors.affiliation: a Department of Paediatrics .
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.affiliation: b Department of Microbiology , and.
authors.forename: Uma
authors.initials: U
authors.lastname: Chaudhary
authors.affiliation: c Department of Biochemistry , Pandit B.D. Sharma Postgraduate Institute of Medical Sciences , Rohtak , Haryana , India.
authors.forename: Seema
authors.initials: S
authors.lastname: Lekhwani
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001769:Blood / Q000382:microbiology; D002710:Chlorhexidine / Q000627:therapeutic use*; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control*; D008297:Male; D018805:Sepsis / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine
keywords: Chlorhexidine; neonatal mortality; neonatal sepsis; skin cleansing