title: Association between serum YKL-40 level and dysglycemia in cystic fibrosis.
abstract: BACKGROUND
  YKL-40, a chitinase-like protein, is a biomarker for type 1 and type 2 diabetes prognosis. We hypothesized that YKL-40 protein levels are elevated in CF patients with dysglycemia.
  
  
  METHODS
  Seventeen healthy control subjects and 66 CF patients were prospectively recruited and subjected to an oral glucose tolerance test. In all participants, fasting serum YKL-40 was compared between control and CF patients and between normal glucose-tolerant patients (NG-CF) and CF patients with dysglycemia (DG-CF). A Botnia clamp procedure was performed on a subset of patients for each group to determine the impact of acute increases of either glucose or insulin on YKL-40 concentration.
  
  
  RESULTS
  CF patients had higher serum YKL-40 values than the controls (113 [49;288] vs. 38 [30;50] ng/ml, p<0.001). YKL-40 concentrations in CF patients were mainly increased in the DG-CF group, who had significantly higher values: 213 [93;383] vs. 67 [27;97] ng/ml in the NG-CF group, p<0.001). No significant modulation of YKL-40 concentration was observed in serum of CF (NG or DG-CF) or non-CF patients, after acute exposure to glucose or insulin.
  
  
  CONCLUSIONS
  Higher serum YKL-40 levels in CF patients are significantly associated with dysglycemia. The increase in YKL-40 is potentially associated with an inflammatory response resulting from chronic glucose intolerance or CF disease evolution.
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada.
authors.forename: Guillaume F
authors.initials: GF
authors.lastname: Bouvet
authors.affiliation: Emergency Department, Grenoble University Hospital, F-38043, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Maignan
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Arslanian
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada.
authors.forename: Adèle
authors.initials: A
authors.lastname: Coriati
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada. Electronic address: yves.berthiaume@ircm.qc.ca.
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthiaume
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000737:chemistry; D015992:Body Mass Index; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D006946:Hyperinsulinism / Q000097:blood; D007328:Insulin / Q000097:blood; D037102:Lectins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D054392:Adipokines; D015415:Biomarkers; D001786:Blood Glucose; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D007328:Insulin; D037102:Lectins
keywords: Botnia clamp; Cystic fibrosis related diabetes; Dysglycemia; Interleukin-8; YKL-40 protein