title: Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population.
abstract: The effects of genetic factors on the noise-induced hearing loss (NIHL) are still unclear. In the present study, eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23), rs1695 (GSTP1), rs137852540 (GJB2), rs2289274 (PMCA2), rs4880 (SOD2), rs7943316, and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers. The results showed that the carriers of the T allele (AT+TT) of rs7943316 and A allele (GA+AA) of rs769214, were significantly associated with an increased risk of NIHL compared to those with AA genotype (P<0.05) and GG genotype (P<0.05). Moreover, a significant three-locus model (P=0.0107) involving rs2016520, rs9794, and rs1805192 were observed that might associated with NIHL, with 53.95% of testing accuracy. Thus, our present study provided the evidence that GJB2, SOD2, and CAT genes might account for the NIHL development in independently and/or in an interactive manner.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China; Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Sheng Li
authors.initials: SL
authors.lastname: Wang
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Lu Gang
authors.initials: LG
authors.lastname: Yu
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Ren Ping
authors.initials: RP
authors.lastname: Liu
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Wan Zhan
authors.initials: WZ
authors.lastname: Zhu
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Wei Min
authors.initials: WM
authors.lastname: Gao
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Li Ping
authors.initials: LP
authors.lastname: Xue
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Ya Han
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Yi
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D002681:China; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D002374:Catalase; D000072259:Connexin 26; D017630:Connexins; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C000607042:GJB2 protein, human