title: High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect.
abstract: We demonstrate an ultrahigh sensitivity silicon photonic biosensor based on cascaded Mach-Zehnder interferometer (MZI) and ring resonator with the Vernier effect using wavelength interrogation. Experimental results show that the sensitivities reached 2870 nm/RIU and 21,500 nm/RIU for MZI sensor and MZI-ring sensor, respectively. A biosensing application was demonstrated by monitoring the interaction between goat and antigoat immunoglobulin G (IgG) pairs. The measured results show that 1 ng/ml IgG resulted in 0.035 nm and 0.5 nm wavelength shift for MZI sensor and MZI-ring sensor, respectively. This high performance sensor is promising for medical diagnostic applications.
authors.forename: Xianxin
authors.initials: X
authors.lastname: Jiang
authors.forename: Yangqing
authors.initials: Y
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Longhua
authors.initials: L
authors.lastname: Tang
authors.forename: Mingyu
authors.initials: M
authors.lastname: Li
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: He
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D006041:Goats; D007074:Immunoglobulin G / Q000276:immunology; D007368:Interferometry / Q000295:instrumentation*; D055096:Optical Devices
chemical_list: D007074:Immunoglobulin G