title: Establishment of the cancer prevention study II nutrition cohort colorectal tissue repository.
abstract: BACKGROUND
  To better understand colorectal cancer etiology and prognosis, archived surgical tissues were collected from Cancer Prevention Study II (CPS-II) Nutrition Cohort participants who were diagnosed with colorectal cancer. Herein, the methodology for this collection is described to help inform other efforts to collect tissues.
  
  
  METHODS
  The main components to accruing tissue were: (i) obtaining consent from participants or next-of-kin; (ii) contacting hospitals to request materials; and (iii) pathology review and laboratory processing.
  
  
  RESULTS
  In CPS-II, we identified 3,643 participants diagnosed with colorectal cancer between 1992/1993 and 2009. Of these, tissue could not be sought from cases verified through state cancer registry linkage (N = 1,622), because of insufficient information on tissue location. We sought tissue from the 2,021 cases verified using medical records, and received tissue from 882. When hospitals were contacted within 10 years of diagnosis, we received 87% of tissue materials; beyond that 10-year mark, we received 32%. Compared with the 2,761 colorectal cancer cases without tissue, the 882 cases with tissue were more likely to be alive, diagnosed more recently during follow-up, and had less-advanced staged disease. Cases with and without tissues were similar with respect to age at diagnosis, smoking, body mass index, physical activity, and other epidemiologic factors.
  
  
  CONCLUSIONS
  Some of the most important elements in forming a tissue repository included having the cases' hospital contact and surgical accession information as well as contacting patients/next-of-kin and hospitals within 10 years of surgery.
  
  
  CONCLUSIONS
  This tissue repository will serve as an important resource for colorectal cancer studies. See all the articles in this CEBP Focus section, "Biomarkers, Biospecimens, and New Technologies in Molecular Epidemiology." Cancer Epidemiol Biomarkers Prev; 23(12); 2694-702. ©2014 AACR.
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia. peter.campbell@cancer.org.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Campbell
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Anusila
authors.initials: A
authors.lastname: Deka
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Peter
authors.initials: P
authors.lastname: Briggs
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Mine
authors.initials: M
authors.lastname: Cicek
authors.affiliation: Department of Pathology, Emory University, Atlanta, Georgia.
authors.forename: Alton B
authors.initials: AB
authors.lastname: Farris
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Mia M
authors.initials: MM
authors.lastname: Gaudet
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Jacobs
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Christina C
authors.initials: CC
authors.lastname: Newton
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Alpa V
authors.initials: AV
authors.lastname: Patel
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Lauren R
authors.initials: LR
authors.lastname: Teras
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Lori
authors.initials: L
authors.lastname: Tillmans
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult