title: Multiple intracranial and spinal metastases from a nonfunctioning pituitary adenoma following multiple surgeries: an illustrative case with 16 years of follow-up.
abstract: Pituitary adenomas are the third most common primary intracranial tumor; however, those with postoperative metastases are very rare and are classically considered as pituitary carcinomas. The field of neurosurgery has struggled with diagnosing and treating these unusual lesions. In this report, we retrospectively analyze the clinical features, imaging findings, pathological characteristics and prognosis of one patient with non-hormone-secreting pituitary adenoma who had multiple intracranial and spinal metastases and underwent four surgeries in a 16-year follow-up period. In addition, on the basis of the existing literature, we explore the underlying mechanisms of, as well as the preventive and therapeutic strategies used to treat, pituitary carcinomas and postoperative metastasis of pituitary tumors.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Er-Meng
authors.initials: EM
authors.lastname: Ma
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wu
authors.forename: Bo Qiu
authors.initials: BQ
authors.lastname: And
authors.affiliation: Department of Neurosurgery, The First Hospital of China Medical University, No, 155, Nanjing North Street, Heping Ward, Shenyang 110001, China. woaishoushu@126.com.
authors.forename: Yun-Jie
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D013125:Spinal Neoplasms / Q000556:secondary / Q000601:surgery*