title: Troponin T: Correlation with location and volume of acute brain infarction.
abstract: BACKGROUND
  The troponin T (cTnT) is frequently elevated in acute ischemic stroke (AIS) patients. However, the relationship, if any, between the cTnT level and brain infarction remains to be established. The aim was to investigate the possible correlation between the location and volume of brain infarction and the cardiac cTnT serum level in AIS patients.
  
  
  METHODS
  The study consisted of consecutive AIS patients admitted within 12h of stroke onset. The location and volume of the acute ischemic lesion was assessed with magnetic resonance imaging. Standard laboratory tests, including cTnT and repeated electrocardiograms, were performed at admission and after 4h. Correlations between the cTnT level and the location and volume of brain infarction and baseline parameters were tested with a Spearman correlation coefficient. Univariate and multiple logistic regression analysis (LRA) were used to determine the possible predictors of cTnT elevation.
  
  
  RESULTS
  Out of the 200 enrolled patients, elevated cTnT was present in 71 (36%). No correlation was found between the cTnT serum levels and the location (P>0.05) nor volume of brain infarction (r=0.05, P=0.48). LRA identified creatinine (OR: 1.26 per 10μmol/L increase; 95% CI: 1.043-1.524), NT-proBNP (OR: 1.05 per 100μg/L increase; 95% CI: 1.018-1.093) and male gender (OR: 3.674; 95% CI: 1.025-13.164) as significant independent predictors of pathological elevation of cTnT.
  
  
  CONCLUSIONS
  Although elevated cTnT serum level is relatively frequent in AIS patients within the first 12h of stroke onset, it is not related to the location or volume of brain infarction.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov (No. NCT01541163).
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Král
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Šaňák
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Veverka
authors.affiliation: Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Hutyra
authors.affiliation: Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Vindiš
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bártková
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Kunčarová
authors.affiliation: Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Dorňák
authors.affiliation: Department of Radiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Čecháková
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Herzig
authors.affiliation: Department of Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Olomouc, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Langová
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Kaňovský
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic; Department of Nursing, Faculty of Health Science, Palacký University, Olomouc, Czech Republic. Electronic address: skoloudik@hotmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Školoudík
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D020520:Brain Infarction / Q000097:blood / Q000175:diagnosis; D003404:Creatinine / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D015203:Reproducibility of Results; D012737:Sex Factors; D013223:Statistics as Topic; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T; D003404:Creatinine
keywords: Acute ischemic stroke; Brain infarction; Cardiac troponin T; Magnetic resonance imaging; Myocardial injury