title: [Impact of lung cancer treatments on renal function].
abstract: BACKGROUND
  Renal failure in patients with lung cancer may be multifactorial: related to the patients and their comorbidities, direct tumor compression or the toxicity of cancer treatments and other associated medications. This literature review is intended to describe the state of knowledge regarding the nephrotoxicity of treatments used in thoracic oncology.
  
  
  RESULTS
  The majority of chemotherapy treatments are potentially nephrotoxic. Cisplatin and pemetrexed exhibit mainly renal tubular toxicity, while vascular renal impairment is found with gemcitabine and bevacizumab. Cisplatin results in acute renal failure in 30% of patients. Renal protective strategies (compliance with recommendations, limitation of nephrotoxic treatments, hydration, magnesium supplementation) must be employed systematically. Targeted therapies do not require any adjustment of the dosage in case of moderate or severe renal insufficiency but adapting the doses of biphosphonates to renal function is necessary.
  
  
  CONCLUSIONS
  This review highlights the need for monitoring of renal function in patients with lung cancer during treatment with chemotherapy or biphosphonates.
authors.affiliation: UM oncologie thoracique, pôle cancérologie médecine aiguë et communautaire, CHU A.-Michallon, BP217, 38043 Grenoble cedex 9, France; Université Grenoble 1, U 823, université J.-Fourier, institut A.-Bonniot, 38706 La Tronche cedex, France. Electronic address: atoffart@chu-grenoble.fr.
authors.forename: A-C
authors.initials: AC
authors.lastname: Toffart
authors.affiliation: Institut de pharmacie, CHU régional de Lille, rue Philippe-Marrache, 59037 Lille cedex, France; Département de biopharmacie, galénique et pharmacie hospitalière, UDSL, EA4481, UFR Pharmacie, université Lille 2, 59000 Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Belaiche
authors.affiliation: UM oncologie thoracique, pôle cancérologie médecine aiguë et communautaire, CHU A.-Michallon, BP217, 38043 Grenoble cedex 9, France; Université Grenoble 1, U 823, université J.-Fourier, institut A.-Bonniot, 38706 La Tronche cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Moro-Sibilot
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Faculté de médecine Lyon Sud, Charles-Mérieux, université Claude-Bernard Lyon 1, 165, chemin du Petit-Revoyet, 69921 Oullins cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Couraud
authors.affiliation: UM oncologie thoracique, pôle cancérologie médecine aiguë et communautaire, CHU A.-Michallon, BP217, 38043 Grenoble cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Sakhri
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D004164:Diphosphonates / Q000009:adverse effects; D005971:Glutamates / Q000008:administration & dosage / Q000009:adverse effects; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D007677:Kidney Function Tests / Q000379:methods; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000068437:Pemetrexed; D000093542:Gemcitabine
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D004164:Diphosphonates; D005971:Glutamates; D000068437:Pemetrexed; D003841:Deoxycytidine; D000068258:Bevacizumab; D006147:Guanine; D002945:Cisplatin; D000093542:Gemcitabine
keywords: Biphosphonates; Cancer broncho-pulmonaire; Cisplatin; Cisplatine; Lung cancer; Pemetrexed; Pémétrexed; Renal toxicity; Toxicité rénale