title: Oncological and surgical results of laparoscopic versus open liver resection for HCC less than 5 cm: case-matched analysis.
abstract: BACKGROUND
  The purpose of this study is the evaluation of the surgical and oncological results of laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) by comparing laparoscopic and open liver resection (OLR) in the treatment of this disease. Retrospective analysis of laparoscopic and OLR for HCC (<5 cm) performed over a 4-year period was conducted. The LLR was done by a single surgeon.
  
  
  METHODS
  The study was performed on patients who received liver resection for HCC between July 2007 and August 2011 in our institution. Propensity-based matched analyses were used to account for operative method selection biases. During the 4 years, 1,050 patients with HCC received an operation. Among them patients who never received TACE or RFA before surgery and had HCC (<5 cm) were selected for this study.
  
  
  RESULTS
  174 patients had OLR, and 58 patients underwent LLR. Patients who received LLR had lower operative time, transfusion rate, complication rate, and shorter hospital days. There were significant differences in hospital mortality and morbidity between the two groups. Dietary recovery was relatively fast in the group of LLR. Overall and disease-free survival rates during the 4 years were also not significantly different between the two groups.
  
  
  CONCLUSIONS
  LLR is a developing and safe technique in a select group of patients including those with malignancies, and use of this procedure is associated with short hospital stays, a rapid return to a normal diet, full mobility, and minimal morbidity, with acceptable oncological parameters. It may be an optimal method of hepatectomy in HCC (<5 cm). Further, long-term follow-up should be acquired for adequate evaluation for survival.
authors.affiliation: Department of Surgery, Korea University Ansan Medical Center, Korea University College of Medicine, Gyeonggi-do, Korea, cdgx287@gmail.com.
authors.forename: Sam-Youl
authors.initials: SY
authors.lastname: Yoon
authors.forename: Ki-Hun
authors.initials: KH
authors.lastname: Kim
authors.forename: Dong-Hwan
authors.initials: DH
authors.lastname: Jung
authors.forename: Ami
authors.initials: A
authors.lastname: Yu
authors.forename: Sung-Gyu
authors.initials: SG
authors.lastname: Lee
mesh_terms: D001803:Blood Transfusion / Q000706:statistics & numerical data; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay / Q000706:statistics & numerical data; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D020127:Recovery of Function; D012189:Retrospective Studies