title: Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77.
abstract: Lycorine, a natural alkaloid, has been widely reported to possess potential efficacy against cancer. However, the anti-multiple myeloma mechanism of lycorine is not fully understood. In this study, the results demonstrated that lycorine is effective against multiple myeloma cell line ARH-77 via inducing programmed necrosis. The mechanisms of lycorine on the multiple myeloma cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage. Our results elucidate the new mechanism of lycorine against multiple myeloma.
authors.affiliation: The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Luo
authors.forename: Mridul
authors.initials: M
authors.lastname: Roy
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Xiao
authors.forename: Shuming
authors.initials: S
authors.lastname: Sun
authors.forename: Long
authors.initials: L
authors.lastname: Liang
authors.forename: Huiyong
authors.initials: H
authors.lastname: Chen
authors.forename: Yin
authors.initials: Y
authors.lastname: Fu
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Mao
authors.initials: M
authors.lastname: Ye
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000096:biosynthesis; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000235:genetics; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D010617:Phenanthridines / Q000008:administration & dosage* / Q000737:chemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D047151:Amaryllidaceae Alkaloids; D010617:Phenanthridines; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D020169:Caspases; C015330:lycorine