title: BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid.
abstract: BACKGROUND
  The recently discovered small-molecule BI-2 potently blocks HIV-1 infection. BI-2 binds to the N-terminal domain of HIV-1 capsid. BI-2 utilizes the same capsid pocket used by the small molecule PF74. Although both drugs bind to the same pocket, it has been proposed that BI-2 uses a different mechanism to block HIV-1 infection when compared to PF74.
  
  
  RESULTS
  This work demonstrates that BI-2 destabilizes the HIV-1 core during infection, and prevents the binding of the cellular factor CPSF6 to the HIV-1 core.
  
  
  CONCLUSIONS
  Overall this short-form paper suggests that BI-2 is using a similar mechanism to the one used by PF74 to block HIV-1 infection.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY, 10461, USA. thomas.fricke@einstein.yu.edu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fricke
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY, 10461, USA. cindy.buffone@phd.einstein.yu.edu.
authors.forename: Cindy
authors.initials: C
authors.lastname: Buffone
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY, 10461, USA. oppsil82@gmx.de.
authors.forename: Silvana
authors.initials: S
authors.lastname: Opp
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY, 10461, USA. oVaCas@me.com.
authors.forename: Jose
authors.initials: J
authors.lastname: Valle-Casuso
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY, 10461, USA. felipe.diaz-griffero@einstein.yu.edu.|Albert Einstein College of Medicine, 1301 Morris Park - Price Center 501, New York, NY, 10461, USA. felipe.diaz-griffero@einstein.yu.edu.
authors.forename: Felipe
authors.initials: F
authors.lastname: Diaz-Griffero
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D002213:Capsid / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000187:drug effects*; D011485:Protein Binding; D014779:Virus Replication / Q000187:drug effects*; D039221:mRNA Cleavage and Polyadenylation Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D019380:Anti-HIV Agents; C450562:cleavage factor Im, human; D039221:mRNA Cleavage and Polyadenylation Factors