title: Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata.
abstract: BACKGROUND
  Alopecia areata (AA) is a common type of hair loss with an autoimmune basis. As the role of homocysteine (Hcys), folate, and CRP has been considered in some autoimmune diseases.
  
  
  OBJECTIVE
  To evaluate homocysteine, folate and CRP level in AA.
  
  
  METHODS
  This study was performed on 29 patients who had AA for at least 6 months affecting more than 20% of scalp, and 32 healthy controls. Levels of serum Hcys, blood high-sensitivity CRP, and RBC folate were measured in all subjects.
  
  
  RESULTS
  The mean level of RBC folate was significantly lower in the patient group than that in controls (P < 0.001). Also, the level of RBC folate was significantly lower in patients with extensive forms of disease (alopecia totalis/alopecia universalis) in comparison with more localized form (patchy hair loss) (P < 0.05). Patients with higher "Severity of Alopecia Total" (SALT) score had lower RBC folate, as well. Serum Hcys and blood high-sensitivity CRP levels did not show a significant difference in two groups.
  
  
  CONCLUSIONS
  Patients with alopecia areata have lower level of RBC folate which is in negative correlation with both severity and extension of AA.
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.affiliation: Conjoint Faculty Member, University of New South Wales, Sydney, Australia.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Namazi
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hoda
authors.initials: H
authors.lastname: Rahimi
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Younespour
authors.affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Amir Houshang
authors.initials: AH
authors.lastname: Ehsani
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Safoura
authors.initials: S
authors.lastname: Shakoei
keywords: Alopecia areata; C-reactive protein; folate; homocysteine