title: Fasting levels of hepatic p-S6 are increased in old mice.
abstract: TOR is involved in aging in a wide range of species from yeast to mammals. Here we show that, after overnight fasting, mTOR activity is higher in the livers of 28 months old female mice compared with middle-aged mice. Taken together with previous reports, our data predict that the life-extending effect of calorie restriction (CR) may be diminished, if CR is started in very old age. In contrast, rapamycin is known to be effective, even when started late in life.
authors.affiliation: a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Leontieva
authors.forename: Geraldine M
authors.initials: GM
authors.lastname: Paszkiewicz
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Blagosklonny
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D016922:Cellular Senescence; D005215:Fasting / Q000378:metabolism*; D005260:Female; D006262:Health; D008099:Liver / Q000378:metabolism*; D008136:Longevity; D008810:Mice, Inbred C57BL; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases
keywords: aging; mTOR; rapalogs; rapamycin; senescence