title: Nonuraemic calciphylaxis: response to treatment with pamidronate and negative pressure therapy.
abstract: Calciphylaxis is a rare cause of skin ulcerations and necrosis in patients with both normal renal and parathyroid function. Although calciphylaxis appears to be on the increase, treatments are mainly empirical, especially for wound care. The lesions in calciphylaxis are typically very painful and carry a high risk of infection, with sepsis being the leading cause of death in this serious disease. We report two cases of nonuraemic calciphylaxis, which responded to treatment with pamidronate and wound management by negative pressure system.
authors.affiliation: Department of Dermatology, Université de Picardie Jules Verne, Amiens University Medical Center, North Hospital, Amiens, France.
authors.forename: A
authors.initials: A
authors.lastname: Lorriaux
authors.forename: G
authors.initials: G
authors.lastname: Chaby
authors.forename: F
authors.initials: F
authors.lastname: Dhaille
authors.forename: A
authors.initials: A
authors.lastname: Dadban
authors.forename: J P
authors.initials: JP
authors.lastname: Arnault
authors.forename: A S
authors.initials: AS
authors.lastname: Dhillies
authors.forename: F
authors.initials: F
authors.lastname: Lombart
authors.forename: D
authors.initials: D
authors.lastname: Chatelain
authors.forename: C
authors.initials: C
authors.lastname: Lok
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002115:Calciphylaxis / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D009767:Obesity, Morbid / Q000150:complications; D000077268:Pamidronate; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate