title: Massive mandibular destruction and alveolar nerve infiltration without lower lip paresthesia in primary intraosseous carcinoma: report of two cases and critical appraisal of diagnostic criteria.
abstract: OBJECTIVE
  To report two cases of solid type primary intraosseous carcinoma (PIOC) with a critical appraisal of one of the WHO diagnostic criteria.
  
  
  CONCLUSIONS
  Both patients had radiographic and histopathologic findings showing massive mandibular destruction as well as the involvement of the inferior alveolar nerve, without lip or chin paresthesia. Patients were treated through hemimandibulectomy followed by reconstruction through fibula free flap and forearm flap.
  
  
  CONCLUSIONS
  Lip and/ or chin paresthesia are rather frequent in metastatic and salivary gland tumors but not in primary tumors of the jaws. Reasons for such a discrepancy are mostly unknown. A few hypotheses are put forward here. It is the opinion of the authors that most of the diagnostic criteria for solid type PIOC are acceptable. However, the criterion "absence of ulcer formation on the overlying mucosa" mainly depends on the dimension of the tumor at diagnosis.
authors.forename: Paolo
authors.initials: P
authors.lastname: Vescovi
authors.forename: Ilaria
authors.initials: I
authors.lastname: Giovannacci
authors.forename: Silvano
authors.initials: S
authors.lastname: Ferrari
authors.forename: Davide
authors.initials: D
authors.lastname: Lanfranco
authors.forename: Domenico
authors.initials: D
authors.lastname: Corradi
authors.forename: Maddalena
authors.initials: M
authors.lastname: Manfredi
authors.forename: Carlo
authors.initials: C
authors.lastname: Fornaini
authors.forename: Mauro
authors.initials: M
authors.lastname: Bonanini
authors.forename: Marco
authors.initials: M
authors.lastname: Meleti
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005360:Fibula / Q000637:transplantation; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008340:Mandibular Nerve / Q000473:pathology*; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D013524:Surgical Flaps