title: n-3 polyunsaturated fatty acids and insulin secretion.
abstract: n-3 polyunsaturated fatty acids (PUFAs) are a subgroup of fatty acids with broad health benefits, such as lowering blood triglycerides and decreasing the risk of some types of cancer. A beneficial effect of n-3 PUFAs in diabetes is indicated by results from some studies. Defective insulin secretion is a fundamental pathophysiological change in both types 1 and 2 diabetes. Emerging studies have provided evidence of a connection between n-3 PUFAs and improved insulin secretion from pancreatic β-cells. This review summarizes the recent findings in this regard and discusses the potential mechanisms by which n-3 PUFAs influence insulin secretion from pancreatic β-cells.
authors.affiliation: Department of AgriculturalFood and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of AgriculturalFood and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3 cbchan@ualberta.ca.
authors.forename: Catherine B
authors.initials: CB
authors.lastname: Chan
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000818:Animals; D004435:Eating; D015525:Fatty Acids, Omega-3 / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D021962:Membrane Microdomains / Q000187:drug effects / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D055571:Secretory Pathway / Q000187:drug effects
chemical_list: D054392:Adipokines; D015525:Fatty Acids, Omega-3; D018836:Inflammation Mediators; D007328:Insulin; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled
keywords: insulin secretion; islets; n-3 PUFA; β-cells