title: Licensed pertussis vaccines in the United States. History and current state.
abstract: The United States switched from whole cell to acellular pertussis vaccines in the 1990s following global concerns with the safety of the whole cell vaccines. Despite high levels of acellular pertussis vaccine coverage, the United States and other countries are experiencing large pertussis outbreaks. The aim of this article is to describe the historical context which led to acellular pertussis vaccine development, focusing on vaccines currently licensed in the US, and to review evidence that waning protection following licensed acellular pertussis vaccines have been significant factors in the widespread reappearance of pertussis.
authors.affiliation: a Kaiser Permanente Vaccine Study Center ; Oakland , CA USA.
authors.forename: Nicola P
authors.initials: NP
authors.lastname: Klein
mesh_terms: D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000517:prevention & control; D004196:Disease Outbreaks; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000266:history / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000266:history / Q000379:methods*; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000266:history / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine; D022282:Vaccines, Acellular
keywords: acellular; history; pertussis; protection; vaccines; waning