title: Down the line from genome-wide association studies in inflammatory bowel disease: the resulting clinical benefits and the outlook for the future.
abstract: Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, is a chronic inflammatory disease of the gut. The etiology of IBD is complex, involving genetic as well as environmental factors. Genetic studies have identified 163 genetic risk loci for IBD, which have led to new insights into the biological mechanisms of the disease. The currently known IBD risk loci show an almost 75% overlap with genetic risk loci for other immune mediated diseases. Current studies are focused on the translation of the identified risk loci to clinical practice. The first steps towards this translation are being taken with the identification of genetic risk factors for drugs toxicity, specific disease course and response to therapy. In this review we will discuss how the IBD genetic risk loci were identified and how this knowledge can be translated towards clinical practice.
authors.affiliation: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Lieke M
authors.initials: LM
authors.lastname: Spekhorst
authors.forename: Marijn C
authors.initials: MC
authors.lastname: Visschedijk
authors.forename: Rinse K
authors.initials: RK
authors.lastname: Weersma
authors.forename: Eleonora Anna
authors.initials: EA
authors.lastname: Festen
mesh_terms: D003093:Colitis, Ulcerative / Q000235:genetics* / Q000628:therapy; D003424:Crohn Disease / Q000235:genetics* / Q000628:therapy; D056426:Genetic Loci; D055106:Genome-Wide Association Study / Q000379:methods* / Q000639:trends; D006801:Humans
keywords: GWAS; crohn’s disease; drug targets; immune mediated diseases; immunochip; inflammatory bowel disease; risk models; ulcerative colitis