title: The prevalence of latent autoimmune diabetes in adults and its correlates in patients with type 2 diabetes in Kerman, Iran [2011].
abstract: BACKGROUND
  Latent autoimmune diabetes in adults [LADA] is a type of autoimmune diabetes in adults that is usually identified by positive GAD-antibody [glutamic acid decarboxylase]. Epidemiological studies show that this disease has no identified prevalence and incidence in Asia due to the various criteria in diagnosing the disease.
  
  
  METHODS
  500 patients with type 2 diabetes based on American Diabetes Association [ADA] criteria and age of diabetes onset above 35 years old who needed no insulin until at least 6 months after the diagnosis of diabetes were selected from KERCADR Study and their anti-GAD serum level was determined.
  
  
  RESULTS
  From 500 patients, 429 ones [85%] were negative and 71 ones [14.2%] were positive for GAD antibody. The prevalence of latent autoimmune diabetes was higher in the age group of 50-59 years compared to the other age groups. There was no significant correlation between LADA and hypertension, family history of diabetes, cigarette smoking and tobacco use.
  
  
  CONCLUSIONS
  The prevalence rate of latent autoimmune diabetes in adults in patients with type 2 diabetes was 14.2% and we could not find any relationship.
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Gozashti Mohammad
authors.initials: GM
authors.lastname: Hossein
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Shafiei
authors.initials: S
authors.lastname: Maryam
authors.affiliation: Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Esmaeilian
authors.initials: E
authors.lastname: Saeed
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Najafipour
authors.initials: N
authors.lastname: Hamid
authors.affiliation: Research Center for Modeling in Health, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: drmahdieh@yahoo.com.
authors.forename: Mashrouteh
authors.initials: M
authors.lastname: Mahdieh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000453:epidemiology* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1
keywords: Adults; Anti GAD; Iran; Latent autoimmune diabetes; Type 2 diabetes