title: Effects of selenium deficiency on principal indexes of chicken kidney function.
abstract: Selenium (Se) deficiency leads to many pathological changes in animals. However, there have been very few reports regarding chicken tissue injury in the kidney caused by Se deficiency. In this study, a chicken Se-deficient disease model has been constructed, and two renal function indexes [including creatinine (CREA) and uric acid (URIC)], seven renal antioxidative function indexes [including glutathione peroxidase (GPx), anti-hydroxyl radical (AHR), catalase (CAT), hydrogen peroxide (H2O2), nitrogen monoxide (NO), glutathione (GSH), and malonyldialdehyde (MDA)], and two organ/tissue injury-related indexes [including inducible nitric oxide synthase (iNOS) and inducible heme oxygenase (HO)-1] were detected and analyzed to investigate the effects of Se deficiency on chicken kidney tissue. The results showed that Se deficiency caused a significant increase in CREA and URIC levels and a decrease in renal antioxidative capacity. Meanwhile, Se deficiency upregulated the expression of organ/tissue injury-related genes, such as the messenger RNA (mRNA) of HO-1 and iNOS as well as their protein expression levels, in the chicken kidney tissue. These data suggest that Se deficiency in birds triggers renal function regression and oxidative stress in the kidney tissue.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Xiangfang District, 150030, Harbin, People's Republic of China.
authors.forename: Dongbo
authors.initials: D
authors.lastname: Sun
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002645:Chickens; D003404:Creatinine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D014527:Uric Acid; D009569:Nitric Oxide; D008315:Malondialdehyde; D003404:Creatinine; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D052247:Nitric Oxide Synthase Type II; D005978:Glutathione; D012643:Selenium