title: Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem.
abstract: Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.
authors.affiliation: R&D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin 446-729, Republic of Korea; Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Park
authors.affiliation: R&D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin 446-729, Republic of Korea.
authors.forename: Si Young
authors.initials: SY
authors.lastname: Cho
authors.affiliation: R&D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin 446-729, Republic of Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, 194-5 Ma-dong, Iksan 570-752, Republic of Korea.
authors.forename: Bong Sik
authors.initials: BS
authors.lastname: Yun
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
authors.forename: Jeong Un
authors.initials: JU
authors.lastname: Kim
authors.affiliation: R&D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin 446-729, Republic of Korea. Electronic address: leesjun@amorepacific.com.
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: foodpro@yonsei.ac.kr.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Park
mesh_terms: D028001:Eleutherococcus / Q000737:chemistry*; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D005663:Furans / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D017705:Lignans / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D056564:Sirtuin 1 / Q000235:genetics* / Q000378:metabolism; D013237:Stereoisomerism; D020349:Surface Plasmon Resonance
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; D012333:RNA, Messenger; C042192:syringaresinol; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Acanthopanax senticosus Harms stem; Enantiomer; Panax ginseng berry pulp; SIRT1; Syringaresinol