title: Microbial production of short chain diols.
abstract: Short chain diols (propanediols, butanediols, pentanediols) have been widely used in bulk and fine chemical industries as fuels, solvents, polymer monomers and pharmaceutical precursors. The chemical production of short chain diols from fossil resources has been developed and optimized for decades. Consideration of the exhausting fossil resources and the increasing environment issues, the bio-based process to produce short chain diols is attracting interests. Currently, a variety of biotechnologies have been developed for the microbial production of the short chain diols from renewable feed-stocks. In order to efficiently produce bio-diols, the techniques like metabolically engineering the production strains, optimization of the fermentation processes, and integration of a reasonable downstream recovery processes have been thoroughly investigated. In this review, we summarized the recent development in the whole process of bio-diols production including substrate, microorganism, metabolic pathway, fermentation process and downstream process.
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. jiangyd@qibebt.ac.cn.|University of Chinese Academy of Sciences, Beijing, China. jiangyd@qibebt.ac.cn.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. liuwei@qibebt.ac.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. zouhb@qibebt.ac.cn.
authors.forename: Huibin
authors.initials: H
authors.lastname: Zou
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. chengtao@qibebt.ac.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Cheng
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. tianning@qibebt.ac.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Tian
authors.affiliation: CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101, China. xianmo@qibebt.ac.cn.
authors.forename: Mo
authors.initials: M
authors.lastname: Xian
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D002072:Butylene Glycols / Q000378:metabolism*; D011409:Propylene Glycols / Q000378:metabolism*
chemical_list: D002072:Butylene Glycols; D011409:Propylene Glycols