title: The prevalence of non organ specific and thyroid autoimmunity in patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is commonly associated with endocrine, metabolic, cardiovascular and other morbidities. However its association with autoimmune diseases is still controversial.
  
  
  OBJECTIVE
  The aim of this study was to assess the prevalence of non organ-specific and antithyroid, antibodies in PCOS women compared to healthy controls.
  
  
  METHODS
  The study included 152 women with PCOS and 76 healthy controls for the evaluation of non organ-specific autoimmunity and 64 PCOS and 68 controls for the study of organ-specific autoimmunity. All sera were tested for autoantibodies.using the ELISA method.
  
  
  RESULTS
  There were no significant differences in the prevalence of ANA, SSA, SSB, anti-dsDNA, anti-RNP, ANCA/MPO or ANCA/PR3 between PCOS and controls. The prevalence of ACLA IgG was higher in controls than PCOS (5.4% v.s. 0%, P=0.011). Patients had a higher prevalence of anti-TPO antibodies (18.75% v.s. 7.35%, P=0.045) and slightly but not significantly higher prevalence of autoimmune thyroiditis (18.75% v.s. 10.29%) than controls.
  
  
  CONCLUSIONS
  The prevalence of non organ-specific autoantibodies in PCOS women is low and similar to controls. On the other hand, we found a slightly higher prevalence of thyroid autoimmunity in PCOS women.
authors.affiliation: 1st Department of Internal Medicine, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Petrikova
authors.affiliation: 1st Department of Internal Medicine, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Ivica
authors.initials: I
authors.lastname: Lazurova
authors.affiliation: 1st Department of Internal Medicine, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dravecka
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Vrbikova
authors.affiliation: National Institute of Rheumatic Disesases, Piestany, Slovak Republic.
authors.forename: Darina
authors.initials: D
authors.lastname: Kozakova
authors.affiliation: 1st Department of Internal Medicine, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Figurova
authors.affiliation: Associated Tissue Bank, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Vaczy
authors.affiliation: Associated Tissue Bank, Medical Faculty, P. J. Safarik University Kosice, Slovak Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Rosocha
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000378:metabolism*; D015551:Autoimmunity / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G
keywords: autoimmune thyroid disease; autoimmunity; hyperandrogenism; polycystic ovary syndrome; systemic autoantibodies