title: [The functional state of the mitochondrial respiratory chain of the small intestine enterocytes of the rats under the low dose rate X-ray total external exposure].
abstract: The influence of the low-rate ionizing radiation (0.055 Gy/min) at the doses of 0.1; 0.5 and 1.0 Gy on the functional state of the mitochondria respiratory chain of the rat small intestine enterocytes was investigated. The dysfunction of the electron transport chain enzymes and changes in the content of cytochromes b, c, a in the mitochondrial inner membrane were revealed 1, 12 and 24 hours after exposure to radiation. The revealed disorders indicate early membrane sensitivity to the radiation effect. The inhibition of the H+ -ATPase activity in the studied dose range indicates the decrease of the mitochondrial energy capacity.
authors.forename: S V
authors.initials: SV
authors.lastname: Khizhniak
authors.forename: L I
authors.initials: LI
authors.lastname: Stepanova
authors.forename: L V
authors.initials: LV
authors.lastname: Grubskaia
authors.forename: V M
authors.initials: VM
authors.lastname: Voĭtsitskiĭ
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004579:Electron Transport / Q000528:radiation effects*; D020895:Enterocytes / Q000528:radiation effects*; D007421:Intestine, Small / Q000528:radiation effects; D008297:Male; D051336:Mitochondrial Membranes / Q000378:metabolism* / Q000528:radiation effects; D010084:Oxidation-Reduction; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D051381:Rats; D014965:X-Rays
chemical_list: D006180:Proton-Translocating ATPases