title: Regular consumption of an antioxidant-rich juice improves oxidative status and causes metabolome changes in healthy adults.
abstract: An improvement in oxidative status is associated with a reduction in the incidence of several chronic diseases. However, daily intake of antioxidants in Western diets is decreasing. This study evaluates the effect of daily consumption of an antioxidant-rich juice (ARJ) on oxidative status, cardiovascular disease risk parameters, and untargeted plasma and urine metabolomes. Twenty-eight healthy young adults participated in an 8-week clinical trial by drinking 200 mL of ARJ (pomegranate and grape) daily. At the end of the study, the subjects showed a significant decrease (-29%) in plasma lipid oxidation (malondialdehyde concentration), and a significant increase (+115%) in plasma antioxidant capacity. Plasma and urine metabolomes were also significantly modified and some ions modified in urine were identified, including metabolites of polyphenols, ascorbic acid and biliary acids. No significant changes were observed in lipid profile, inflammation, blood pressure or glycaemia. These results show that incorporating antioxidant-rich beverages into common diets may improve oxidative status in healthy subjects.
authors.affiliation: Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais, 10, 28040, Madrid, Spain.
authors.forename: M Elena
authors.initials: ME
authors.lastname: Díaz-Rubio
authors.forename: Jara
authors.initials: J
authors.lastname: Pérez-Jiménez
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Martínez-Bartolomé
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Álvarez
authors.forename: Fulgencio
authors.initials: F
authors.lastname: Saura-Calixto
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000097:blood / Q000652:urine; D001628:Beverages; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000178:diet therapy; D008055:Lipids / Q000097:blood; D029561:Lythraceae; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D055442:Metabolome / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000097:blood / Q000652:urine; D027843:Vitis
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008055:Lipids; D059808:Polyphenols; D008315:Malondialdehyde; D001205:Ascorbic Acid