title: Bioactive nucleoside analogues possessing selected five-membered azaheterocyclic bases.
abstract: This review summarizes briefly literature reports on nucleoside analogues containing five-membered aglycones based on imidazole-4-carboxamide, 1,2,4-triazole-3-carboxamide or 1,2,3-triazole-4-carboxamide structural motifs, which exhibit diverse therapeutically useful or promising biological properties. We do not describe synthetic approaches but try to present the essential activities of compounds and their established or postulated mechanisms of action.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zeidler
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Baraniak
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland. Electronic address: tostr@ibch.poznan.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ostrowski
mesh_terms: D000818:Animals; D001372:Aza Compounds / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001372:Aza Compounds; D006571:Heterocyclic Compounds; D009705:Nucleosides
keywords: 1,2,3-Triazole nucleosides; 1,2,4-Triazole nucleosides; Imidazole nucleosides; Mechanism of action; Ribavirin