title: Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.
abstract: BACKGROUND
  Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.
  
  
  METHODS
  This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.
  
  
  RESULTS
  Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.
  
  
  CONCLUSIONS
  The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.
authors.affiliation: Department of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, Room 334, 3rd Floor, New York, NY, 10016, USA, Gregory.chang@nyumc.org.
authors.forename: Gregory
authors.initials: G
authors.lastname: Chang
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hotca-Cho
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.forename: Stephen
authors.initials: S
authors.lastname: Honig
authors.forename: Artem
authors.initials: A
authors.lastname: Mikheev
authors.forename: Kenneth
authors.initials: K
authors.lastname: Egol
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
authors.forename: Chamith S
authors.initials: CS
authors.lastname: Rajapakse
mesh_terms: D055119:Elastic Modulus; D005260:Female; D005269:Femur / Q000473:pathology*; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000473:pathology*; D015203:Reproducibility of Results