title: The medicinal chemistry of genus Aralia.
abstract: The genus Aralia contains many plants used medicinally in Asia and the Americas. Although many members of this genus are used medicinally, the vast majority of this genus has not been explored chemically. The species of Aralia that have been explored chemically have yielded compounds of several classes, including triterpenoid saponins, sterols, diterpenoids, and acetylenic lipids. Many of the biologically active components found in genus Aralia have been evaluated for their potential as lead compounds for drug discovery. This review will explore the medicinal chemistry of compounds reported from genus Aralia, and future prospects for this genus will be considered.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Clement
authors.affiliation: Natural Products Discovery Institute, Baruch S. Blumberg Institute, 3805 Old Easton Rd., Doylestown, PA, 18960, USA. jason.clement@npdi-us.org.
authors.forename: Ella S H
authors.initials: ES
authors.lastname: Clement
mesh_terms: D000480:Alkynes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027983:Aralia / Q000737:chemistry* / Q000145:classification; D001688:Biological Products / Q000737:chemistry; D002316:Cardiotonic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000480:Alkynes; D000893:Anti-Inflammatory Agents; D019440:Anti-Obesity Agents; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D002316:Cardiotonic Agents; D004224:Diterpenes; D007004:Hypoglycemic Agents; D007155:Immunologic Factors; D008055:Lipids; D012503:Saponins; D009828:Oleanolic Acid