title: Gut microbes and adverse food reactions: Focus on gluten related disorders.
abstract: Immediately following birth, the gastrointestinal tract is colonized with a complex community of bacteria, which helps shape the immune system. Under conditions of health, the immune system is able to differentiate between innocuous antigens, including food protein and commensals, and harmful antigens such as pathogens. However, patients with celiac disease (CD) develop an intolerance to gluten proteins which results in a pro-inflammatory T-cell mediated immune response with production of anti-gluten and anti-tissue transglutaminase antibodies. This adaptive immune response, in conjunction with activation of innate inflammatory cells, lead to destruction of the small intestinal mucosa. Overall 30% of the global population has genetic risk to develop CD. However, only a small proportion develop CD, suggesting that additional environmental factors must play a role in disease pathogenesis. Alterations in small intestinal microbial composition have recently been associated with active CD, indicating a possible role for the microbiota in CD. However, studies demonstrating causality are lacking. This review will highlight the recent data on the potential role of the microbiota in CD pathogenesis, the potential mechanisms, and discuss future research directions.
authors.affiliation: a Farncombe Family Digestive Health Research Institute ; McMaster University ; Hamilton , Canada.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Galipeau
authors.forename: Elena F
authors.initials: EF
authors.lastname: Verdu
mesh_terms: D002446:Celiac Disease / Q000382:microbiology* / Q000473:pathology*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D005983:Glutens / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D064307:Microbiota
chemical_list: D005983:Glutens
keywords: CD, celiac disease; CTL, cytotoxic T lymphocytes; DC, dendritic cell; EC, epithelial cell.; FISH, fluorescence in situ hybridization; GALT, gut associated lymphoid tissue; GFD, gluten-free diet; GRD, gluten related disorders; IBD, inflammatory bowel disease; IEL, intraepithelial lymphocyte; MLN, mesenteric lymph node; PBMC, peripheral blood mononuclear cell; SCFA, short chain fatty acids; SFB, segmented filamentous bacteria; TG2, tissue transglutaminase; Tregs, regulatory T cells; WT, wild-type; celiac disease; gluten related disorders; immune homeostasis; microbiota; oral tolerance