title: Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy.
abstract: A novel hyaluronic acid modified transfersome was prepared to deliver drugs to lymphatics through the transdermal route. Doxorubicin loaded HA-GMS-T was able to efficiently penetrate into the deep skin tissue, leading to enhanced absorption by lymphatics. Most importantly, hyaluronic acid effectively improved the uptake of drug loaded nanocarriers by tumor cells.
authors.affiliation: Biochemistry and biomaterial key laboratory of Shandong colleges and universities, College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao, China. kongming@ouc.edu.cn xgchen@ouc.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Kong
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Cheng
authors.forename: Xiguang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D005990:Glycerol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000737:chemistry; D008081:Liposomes; D008099:Liver / Q000378:metabolism; D008208:Lymphatic System / Q000378:metabolism; D061986:MCF-7 Cells; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013228:Stearates / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D013228:Stearates; C529864:glycerol 1-stearate; D004317:Doxorubicin; D006820:Hyaluronic Acid; D005990:Glycerol