title: Ephrin-Eph signaling in embryonic tissue separation.
abstract: The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences in cell-cell adhesion. However, vertebrate embryonic tissues also express a variety of cell surface cues, in particular ephrins and Eph receptors, and there is now firm evidence that these molecules are systematically used to induce local repulsion at contacts between different cell types, efficiently preventing mixing of adjacent cell populations.
authors.affiliation: a Dpt. of Biology ; McGill University ; Montreal , Quebec , Canada.
authors.forename: Francois
authors.initials: F
authors.lastname: Fagotto
authors.forename: Rudolf
authors.initials: R
authors.lastname: Winklbauer
authors.forename: Nazanin
authors.initials: N
authors.lastname: Rohani
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D002642:Chick Embryo; D047108:Embryonic Development; D036342:Ephrins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009024:Morphogenesis; D036081:Receptors, Eph Family / Q000378:metabolism*; D015398:Signal Transduction; D014981:Xenopus; D015027:Zebrafish
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family
keywords: Cell adhesion; Cell sorting; Contact inhibition; Differential adhesion; Embryonic Development; Morphogenesis; Signaling