title: Silver-catalyzed C(sp2)-H functionalization/C-O cyclization reaction at room temperature.
abstract: Silver-catalyzed C(sp(2))-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.
authors.affiliation: School of Medical Engineering, Hefei University of Technology , Hefei 230009, P. R. China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Dai
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Xu
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Wu
authors.forename: Wen-Man
authors.initials: WM
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Gong
authors.forename: Xia-Ping
authors.initials: XP
authors.lastname: He
authors.forename: Xin-Qing
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Hua-Jian
authors.initials: HJ
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry*; D013696:Temperature
chemical_list: D007783:Lactones; D012834:Silver; D012835:Silver Nitrate