title: Noncoding RNAs as epigenetic mediators of skeletal muscle regeneration.
abstract: Skeletal muscle regeneration is a well-characterized biological process in which resident adult stem cells must undertake a series of cell-fate decisions to ensure efficient repair of the damaged muscle fibers while also maintaining the stem cell niche. Satellite cells, the main stem cell contributing to the repaired muscle fiber, are maintained in a quiescent state in healthy muscle. Upon injury, the satellite cells become activated, and proliferate to expand the muscle progenitor cell population before returning to the quiescent state or differentiating to become myofibers. Importantly, the determination of cell fate is controlled at the epigenetic level in response to environmental cues. In this review, we discuss our current understanding of the role played by noncoding RNAs (both miRNAs and long-noncoding RNAs) in the epigenetic control of muscle regeneration.
authors.affiliation: Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Canada.
authors.forename: Gurjeev
authors.initials: G
authors.lastname: Sohi
authors.forename: Francis Jeffrey
authors.initials: FJ
authors.lastname: Dilworth
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D022661:RNA, Untranslated / Q000235:genetics*; D012038:Regeneration
chemical_list: D022661:RNA, Untranslated
keywords: MyoD; differentiation; epigenetics; gene expression; lncRNAs; miRNAs; myoMiRs; myogenesis; satellite cells; skeletal muscle