title: A case of occupational bile duct carcinoma following exposure to a chlorinated organic solvent in the printing industry that was recognized as a work-related accident.
abstract: A man in his 40s presented with liver dysfunction on a screening examination. He was working in the printing industry and had been exposed to a chlorinated organic solvent for 12 years from the age of 20. Detailed examination revealed hilar bile duct cancer; proton radiotherapy was initiated. About three years after completing the proton radiotherapy, recurrence was suspected in hepatic hilar lymph nodes on radiological examination, and he was referred to our hospital. Endoscopic ultrasound-guided fine-needle aspiration of hepatic hilar lymph nodes revealed adenocarcinoma, and systemic chemotherapy was started. Two years later, the lymph nodes showed tumor regrowth, and surgical lymph node resection was performed. To date, 20 months after resection, no recurrence has been identified. We report a case of bile duct carcinoma that was recognized as a work-related accident in an individual working in the printing industry.
authors.affiliation: Department of Gastroenterolgy, Aichi Cancer Center Hospital.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Fujiyoshi
authors.forename: Susumu
authors.initials: S
authors.lastname: Hijioka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imaoka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hara
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Mizuno
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tajika
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamao
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000532:radiotherapy / Q000601:surgery; D001650:Bile Duct Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects*; D008207:Lymphatic Metastasis; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011327:Printing; D012008:Recurrence; D012997:Solvents / Q000009:adverse effects
chemical_list: D006843:Hydrocarbons, Chlorinated; D012997:Solvents