title: An open investigation of the reproducibility of cancer biology research.
abstract: It is widely believed that research that builds upon previously published findings has reproduced the original work. However, it is rare for researchers to perform or publish direct replications of existing results. The Reproducibility Project: Cancer Biology is an open investigation of reproducibility in preclinical cancer biology research. We have identified 50 high impact cancer biology articles published in the period 2010-2012, and plan to replicate a subset of experimental results from each article. A Registered Report detailing the proposed experimental designs and protocols for each subset of experiments will be peer reviewed and published prior to data collection. The results of these experiments will then be published in a Replication Study. The resulting open methodology and dataset will provide evidence about the reproducibility of high-impact results, and an opportunity to identify predictors of reproducibility.
authors.affiliation: Timothy M Errington Center for Open Science, Charlottesville, United States.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Errington
authors.affiliation: Elizabeth Iorns Science Exchange, Palo Alto, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Iorns
authors.affiliation: William Gunn Mendeley, London, United Kingdom.
authors.forename: William
authors.initials: W
authors.lastname: Gunn
authors.affiliation: Fraser Elisabeth Tan Science Exchange, Palo Alto, United States.
authors.forename: Fraser Elisabeth
authors.initials: FE
authors.lastname: Tan
authors.affiliation: Joelle Lomax Science Exchange, Palo Alto, United States.
authors.forename: Joelle
authors.initials: J
authors.lastname: Lomax
authors.affiliation: Brian A Nosek University of Virginia, Charlottesville, United States; Center for Open Science, Charlottesville, United States.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Nosek
mesh_terms: D035843:Biomedical Research; D006801:Humans; D009369:Neoplasms; D015203:Reproducibility of Results
keywords: human; human biology; medicine; methodology; mouse; open science; replication; reproducibility; reproducibility project: cancer biology