title: Synthesis of OSW-1 derivatives by site-selective acylation and their biological evaluation.
abstract: A strategy to site-selectively monoacylate an antitumor saponin OSW-1 was developed using an organotin reagent to rapidly access its derivatives that are useful as chemical probes. 4″-O-Acylated OSW-1 derivatives bearing a fluorophore, an alkyne tag, or biotin were prepared in good yields and were shown to maintain highly cytotoxic activity.
authors.affiliation: Tokyo University of Agriculture and Technology , Department of Biotechnology and Life Science, Koganei-shi, Tokyo 184-8588, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakurai
authors.forename: Tomoya
authors.initials: T
authors.lastname: Takeshita
authors.forename: Masato
authors.initials: M
authors.lastname: Hiraizumi
authors.forename: Rika
authors.initials: R
authors.lastname: Yamada
mesh_terms: D000215:Acylation; D001710:Biotin / Q000737:chemistry*; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D002783:Cholestenones; D012503:Saponins; C106408:OSW 1; D001710:Biotin