title: Peptide-directed self-assembly of functionalized polymeric nanoparticles. Part II: effects of nanoparticle composition on assembly behavior and multiple drug loading ability.
abstract: Peptide-functionalized polymeric nanoparticles were designed and self-assembled into continuous nanoparticle fibers and three-dimensional scaffolds via ionic complementary peptide interaction. Different nanoparticle compositions can be designed to be appropriate for each desired drug, so that the release of each drug is individually controlled and the simultaneous sustainable release of multiple drugs is achieved in a single scaffold. A self-assembled scaffold membrane was incubated with NIH3T3 fibroblast cells in a culture dish that demonstrated non-toxicity and non-inhibition on cell proliferation. This type of nanoparticle scaffold combines the advantages of peptide self-assembly and the versatility of polymeric nanoparticle controlled release systems for tissue engineering.
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, 49931, Michigan.
authors.forename: Xu
authors.initials: X
authors.lastname: Xiang
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Ding
authors.forename: Trevor
authors.initials: T
authors.lastname: Moser
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
authors.forename: Tolou
authors.initials: T
authors.lastname: Shokuhfar
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Heiden
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: D010455:Peptides
keywords: controlled release; multi-drug loading; nanoparticle scaffold; peptides; self-assembly