title: Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration.
abstract: The nHAC/CSH composite is an injectable bone repair material with controllable injectability and self-setting properties prepared by introducing calcium sulfate hemihydrate (CSH) into mineralized collagen (nHAC). When mixed with water, the nHAC/CSH composites can be transformed into mineralized collagen/calcium sulfate dihydrate (nHAC/CSD) composites. The nHAC/CSD composites have good biocompatibility and osteogenic capability. Considering that the degradation behavior of bone repair material is another important factor for its clinical applications, the degradability of nHAC/CSD composites was studied. The results showed that the degradation ratio of the nHAC/CSD composites with lower nHAC content increased with the L/S ratio increase of injectable materials, but the variety of L/S ratio had no significant effect on the degradation ratio of the nHAC/CSD composites with higher nHAC content. Increasing nHAC content in the composites could slow down the degradation of nHAC/CSD composite. Setting accelerator had no significant effect on the degradability of nHAC/CSD composites. In vivo histological analysis suggests that the degradation rate of materials can match the growth rate of new mandibular bone tissues in the implanted site of rabbit. The regulable degradability of materials resulting from the special prescriptions of injectable nHAC/CSH composites will further improve the workability of nHAC/CSD composites.
authors.affiliation: National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China; Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, PR China. Electronic address: chenzg@sdu.edu.cn.
authors.forename: Zonggang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, PR China.
authors.forename: Qing-Yuan
authors.initials: QY
authors.lastname: Meng
authors.affiliation: Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110001, PR China.
authors.forename: Huanye
authors.initials: H
authors.lastname: Liu
authors.affiliation: Jinan Military General Hospital of PLA, Jinan 250031, PR China.
authors.forename: Zhaoliang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China. Electronic address: zwguo@sdu.edu.cn.
authors.forename: Zhongwu
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, PR China. Electronic address: cuifz@mail.tsinghua.edu.cn.
authors.forename: Fu-Zhai
authors.initials: FZ
authors.lastname: Cui
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002133:Calcium Sulfate / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D006801:Humans; D008334:Mandible / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D003094:Collagen; D002133:Calcium Sulfate
keywords: Bone repair materials; Calcium sulfate; Degradability; Mineralized collagen; Tissue regeneration