title: Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans.
abstract: OBJECTIVE
  To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans.
  
  
  METHODS
  Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulin G levels were analyzed using enzyme-linked fluorescent assay.
  
  
  RESULTS
  During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulin G antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P = 0.002; OR 1.023, 95% CI 1.001-1.047, P = 0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r = 0.303, P = 0.002), CD8+ T-lymphocyte count (r = 0.313, P = 0.001) and instrumental activities of daily living scores (r = 0.217, P = 0.028). In addition, HCMV immunoglobulin G titers were inversely associated with estimated glomerular filtration rate (r = -0.268, P = 0.006). These four variables remained independently significant in multivariate correlation analysis.
  
  
  CONCLUSIONS
  These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly.
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Chang Oh
authors.initials: CO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D015992:Body Mass Index; D016516:CD4-CD8 Ratio; D003587:Cytomegalovirus / Q000276:immunology*; D000075222:Essential Hypertension; D005260:Female; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology* / Q000821:virology*; D007136:Immunoglobulins / Q000097:blood*; D016756:Immunoglobulins, Intravenous; D008297:Male; D011446:Prospective Studies; D056910:Republic of Korea
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; C045781:cytomegalovirus-specific hyperimmune globulin
keywords: antibody; cytomegalovirus; elderly patients; functional status; hypertension