title: Prevalence of Atherogenic Dyslipidemia in Spanish Hypertensive Patients and Its Relationship With Blood Pressure Control and Silent Organ Damage.
abstract: OBJECTIVE
  To assess the prevalence of atherogenic dyslipidemia in hypertensive patients and its relationship with risk profile and blood pressure control.
  
  
  METHODS
  The study included 24 351 hypertensive patients from the Spanish Ambulatory Blood Pressure Monitoring Registry. Atherogenic dyslipidemia was defined as the presence of hypertriglyceridemia (> 150mg/dL) and low levels of high-density lipoprotein cholesterol (< 40mg/dL in men and < 46mg/dL in women). Blood pressure control was assessed by office and ambulatory monitoring.
  
  
  RESULTS
  Atherogenic dyslipidemia was present in 2705 patients (11.1%). Of these, 30% had hypertriglyceridemia and 21.7% had low levels of high-density lipoprotein cholesterol. Compared with patients without these risk factors, the former group were more often male (60% vs 52%), younger (57 years vs 59 years), had other risk factors and organ damage (microalbuminuria, reduced estimated glomerular filtration rate, and left ventricular hypertrophy), worse office, diurnal, and nocturnal blood pressure values (odds ratio 1.09, 1.06, and 1.10, respectively), and the lowest nocturnal blood pressure reduction (odds ratio=1.07), despite the greater use of antihypertensive drugs.
  
  
  CONCLUSIONS
  Atherogenic dyslipidemia is present in more than 10% of hypertensive patients and is associated with other risk factors, organ damage, and poorer blood pressure control. Greater therapeutic effort is needed to reduce overall risk in these patients.
authors.affiliation: Unidad de Hipertensión, Servicio de Medicina Interna, Hospital Mútua de Terrassa, Universidad de Barcelona, Terrassa, Barcelona, Spain. Electronic address: adelasierra@mutuaterrassa.cat.
authors.forename: Alejandro
authors.initials: A
authors.lastname: de la Sierra
authors.affiliation: Servicio de Nefrología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gorostidi
authors.affiliation: Servicio de Nefrología, Hospital Carlos Haya, Málaga, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Aranda
authors.affiliation: Servicio de Medicina Interna, Hospital de Bellvitge, Universidad de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Emili
authors.initials: E
authors.lastname: Corbella
authors.affiliation: Servicio de Medicina Interna, Hospital de Bellvitge, Universidad de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pintó
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D002318:Cardiovascular Diseases / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000150:complications / Q000453:epidemiology*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012042:Registries; D013030:Spain / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D014280:Triglycerides
keywords: Ambulatory blood pressure monitoring; Atherogenic dyslipemia; Blood pressure control; Control de la presión arterial; Dislipemia aterogénica; Hipertensión arterial; Hipertrigliceridemia; Hypertension; Hypertryglyceridemia; Lesión del órgano diana; Monitorización ambulatoria de la presión arterial; Target organ damage