title: Brain Graph Topology Changes Associated with Anti-Epileptic Drug Use.
abstract: Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using graph theory analysis. Patients were divided into two groups based on anti-epileptic medication use: those taking carbamazepine/oxcarbazepine (CBZ/OXC) (n=9) and those not taking CBZ/OXC (n=16) as a part of their medication regimen. The following graph topology metrics were analyzed: global efficiency, betweenness centrality (BC), clustering coefficient, and small-world index. Multiple linear regression was used to examine the association of CBZ/OXC with graph topology. The two groups did not differ from each other based on epilepsy characteristics. Use of CBZ/OXC was associated with a lower BC. Longer epilepsy duration was also associated with a lower BC. These findings can inform graph theory-based studies in patients with TLE. The changes observed are discussed in relation to the anti-epileptic mechanism of action and adverse effects of CBZ/OXC.
authors.affiliation: 1 Department of Neurology, Baylor College of Medicine , Houston, Texas.|2 Neurology Care Line, VA Medical Center , Houston, Texas.
authors.forename: Zulfi
authors.initials: Z
authors.lastname: Haneef
authors.affiliation: 3 Department of Physical Medicine, Baylor College of Medicine , Houston, Texas.
authors.forename: Harvey S
authors.initials: HS
authors.lastname: Levin
authors.affiliation: 4 Department of Statistics, Rice University , Houston, Texas.
authors.forename: Sharon
authors.initials: S
authors.lastname: Chiang
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D001931:Brain Mapping; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D000078330:Oxcarbazepine; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D010100:Oxygen; D000078330:Oxcarbazepine
keywords: anti-epileptic drugs; betweenness centrality; carbamazepine; clustering coefficient; global efficiency; graph theory; small-world index; temporal lobe epilepsy