title: miRNome of inflammatory breast cancer.
abstract: BACKGROUND
  Inflammatory breast cancer (IBC) is an extremely malignant form of breast cancer which can be easily misdiagnosed. Conclusive prognostic IBC molecular biomarkers which are also providing the perspectives for targeted therapy are lacking so far. The aim of this study was to reveal the IBC-specific miRNA expression profile and to evaluate its association with clinicopathological parameters.
  
  
  METHODS
  miRNA expression profiles of 13 IBC and 17 non-IBC patients were characterized using comprehensive Affymetrix GeneChip miRNA 3.0 microarray platform. Bioinformatic analysis was used to reveal IBC-specific miRNAs, deregulated pathways and potential miRNA targets.
  
  
  RESULTS
  31 differentially expressed miRNAs characterize IBC and mRNAs regulated by them and their associated pathways can functionally be attributed to IBC progression. In addition, a minimal predictive set of 4 miRNAs characteristic for the IBC phenotype and associated with the TP53 mutational status in breast cancer patients was identified.
  
  
  CONCLUSIONS
  We have characterized the complete miRNome of inflammatory breast cancer and found differentially expressed miRNAs which reliably classify the patients to IBC and non-IBC groups. We found that the mRNAs and pathways likely regulated by these miRNAs are highly relevant to cancer progression. Furthermore a minimal IBC-related predictive set of 4 miRNAs associated with the TP53 mutational status and survival for breast cancer patients was identified.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Maltseva
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Galatenko
authors.affiliation: SRC Bioclinicum, Ugreshskaya str 2/85, 115088 Moscow, Russia. t.samatov@bioclinicum.com.
authors.forename: Timur R
authors.initials: TR
authors.lastname: Samatov
authors.forename: Svetlana O
authors.initials: SO
authors.lastname: Zhikrivetskaya
authors.forename: Nadezhda A
authors.initials: NA
authors.lastname: Khaustova
authors.forename: Ilya N
authors.initials: IN
authors.lastname: Nechaev
authors.forename: Maxim U
authors.initials: MU
authors.lastname: Shkurnikov
authors.forename: Alexey E
authors.initials: AE
authors.lastname: Lebedev
authors.forename: Irina A
authors.initials: IA
authors.lastname: Mityakina
authors.forename: Andrey D
authors.initials: AD
authors.lastname: Kaprin
authors.forename: Udo
authors.initials: U
authors.lastname: Schumacher
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Tonevitsky
mesh_terms: D016000:Cluster Analysis; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged
chemical_list: D035683:MicroRNAs