title: Diagnosis and management of DNA mismatch repair-deficient colorectal cancer.
abstract: Colorectal tumors exhibiting defective DNA mismatch repair (MMR-D)/microsatellite instability (MSI-H) form a distinct subgroup of CRCs associated with important clinical and pathologic features. The identification of MMR-D/MSI-H may impact CRC prognosis, prediction of response to chemotherapeutic agents, and may necessitate the need for genetic assessment for Lynch syndrome. Oncologists remain at the forefront of diagnosing, treating, and managing patients with MMR-D/MSI-H CRC and ensuring that the clinical care of these patients reflect our evolving understanding of this unique CRC subtype.
authors.affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: stadlerz@mskcc.org.
authors.forename: Zsofia K
authors.initials: ZK
authors.lastname: Stadler
mesh_terms: D000236:Adenoma / Q000235:genetics; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D053843:DNA Mismatch Repair; D019468:Disease Management; D055088:Early Detection of Cancer; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D053842:Microsatellite Instability; D011379:Prognosis
chemical_list: D005472:Fluorouracil
keywords: Colorectal cancer prognosis; Microsatellite instability; Mismatch repair deficiency