title: Radiation and inflammation.
abstract: The immune system has the power to modulate the expression of radiation-induced normal and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the other hand, it can influence acute and late radiation side effects, which in many ways resemble acute and chronic inflammatory disease states. The way radiation-induced inflammation feeds into adaptive antigen-specific immune responses adds another dimension to the tumor-host cross talk during radiation therapy and to possible radiation-driven autoimmune responses. Understanding how radiation affects inflammation and immunity is therefore critical if we are to effectively manipulate these forces for benefit in radiation oncology treatments.
authors.affiliation: Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
authors.forename: Dörthe
authors.initials: D
authors.lastname: Schaue
authors.affiliation: Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
authors.forename: Ewa D
authors.initials: ED
authors.lastname: Micewicz
authors.affiliation: Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
authors.forename: Josephine A
authors.initials: JA
authors.lastname: Ratikan
authors.affiliation: Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Xie
authors.affiliation: Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.
authors.forename: Genhong
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA. Electronic address: wmcbride@mednet.ucla.edu.
authors.forename: William H
authors.initials: WH
authors.lastname: McBride
mesh_terms: D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000528:radiation effects*; D007249:Inflammation / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000276:immunology*