title: Functions of lncRNA HOTAIR in lung cancer.
abstract: Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognosis. Moreover, HOTAIR promotes proliferation, survival, invasion, metastasis, and drug resistance in lung cancer cells. Here we review the molecular mechanisms underlying HOTAIR-mediated aggressive phenotypes of lung cancer. We also discuss HOTAIR's potential in diagnosis and treatment of lung cancer, as well as the challenges of exploiting HOTAIR for intervention of lung cancer.
authors.affiliation: Providence Regional Cancer Center, 105 W. 8th Avenue, Spokane, WA, 99204, USA. gregory.loewen@gmail.com.
authors.forename: Gregory
authors.initials: G
authors.lastname: Loewen
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, LA, 70118, USA. jananj@tulane.edu.
authors.forename: Janarthanan
authors.initials: J
authors.lastname: Jayawickramarajah
authors.affiliation: Kadlec Regional Medical Center, 888 Swift Boulevard, Richland, WA, 99352, USA. zhuoying1@yahoo.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhuo
authors.affiliation: College of Medical Sciences, Washington State University Spokane, 412 E. Spokane Falls Boulevard, Spokane, WA, 99202, USA. bin.shan@wsu.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: Shan
mesh_terms: D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011379:Prognosis; D016372:RNA, Antisense / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C561566:HOTAIR long untranslated RNA, human; D016372:RNA, Antisense; D062085:RNA, Long Noncoding