title: Synthetic approach toward complexity of sialic acid-containing glycans.
abstract: The biological relevance of sialic acid-containing glycans (sialo-glycans) to various interactions at the cell surface has increased the demand for the supply of structurally defined sialo-glycans. Due to their unique structures, the stereoselective synthesis of glycosides of sialic acid is inherently difficult, which makes the synthetic approach to synthesize diverse and complex sialo-glycans far from successful. However, the gap between the chemical and natural synthesis of complex sialo-glycans is narrowing through the emergence of synthetic methods. This review highlights recent progress made in the synthesis of complex sialo-glycans via cutting-edge synthetic methods.
authors.affiliation: a Department of Applied Bioorganic Chemistry , Gifu University , Gifu , Japan.
authors.forename: Hiromune
authors.initials: H
authors.lastname: Ando
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006031:Glycosylation; D006878:Hydroxides / Q000737:chemistry; D019158:N-Acetylneuraminic Acid; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D006878:Hydroxides; D011134:Polysaccharides; C031356:hydroxide ion; D019158:N-Acetylneuraminic Acid
keywords: glycan; glycosylation; organic synthesis; sialic acid