title: Incorporating privileged genetic information for fundus image based glaucoma detection.
abstract: Visual features extracted from retinal fundus images have been increasingly used for glaucoma detection, as those images are generally easy to acquire. In recent years, genetic researchers have found that some single nucleic polymorphisms (SNPs) play important roles in the manifestation of glaucoma and also show superiority over fundus images for glaucoma detection. In this work, we propose to use the SNPs to form the so-called privileged information and deal with a practical problem where both fundus images and privileged genetic information exist for the training subjects, while the test objects only have fundus images. To solve this problem, we present an effective approach based on the learning using privileged information (LUPI) paradigm to train a predictive model for the image visual features. Extensive experiments demonstrate the usefulness of our approach in incorporating genetic information for fundus image based glaucoma detection.
authors.forename: Lixin
authors.initials: L
authors.lastname: Duan
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Xu
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Damon Wing Kee
authors.initials: DW
authors.lastname: Wing
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001185:Artificial Intelligence; D020000:Decision Support Systems, Clinical; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005451:Fluorescein Angiography; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D005901:Glaucoma / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity