title: [Intra-articular injections of triamcinolone hexacetonide in rheumatoid arthritis: short and long-term improvement predictors].
abstract: OBJECTIVE
  Identify good response predictors to intra-articular injection (IAI) with triamcinolone hexacetonide (TH).
  
  
  METHODS
  This study was carried out in rheumatoid arthritis (RA) patients (American College of Rheumatology criteria) submitted to IAI (mono, pauci or polyarticular injection).
  
  
  RESULTS
  A "blinded" observer prospectively evaluated joints at one week (T1), four weeks (T4), twelve weeks (T12) and 24 weeks (T24) after IAI. Outcome measurements included Visual Analogue Scale (0-10 cm) at rest, in movement and for swollen joints. Clinical, demographic and variables related to injection at baseline were analyzed according to IAI response.
  
  
  RESULTS
  We studied 289 patients with RA (635 joints) with a mean age of 48.7 years (±10.68), 48.5% of them Caucasians, VAS for global pain=6.52 (±1.73). Under univariate analysis, the variables relating the best responses following IAI (improvement > 70%) were: "elbow and metacarpophalangeal (MCP) IAI, and functional class II". Under multivariate analysis, "males" and "non-whites" were the predictors with the best response to IAI at T4, while "elbow and MCP IAI", "polyarticular injection", "use of methotrexate" and "higher total dose of TH" obtained the best response at T24.
  
  
  CONCLUSIONS
  Several predictors of good response to IAI in patients with RA were identified. The best-response predictors for TH IAI of long term were "apply elbow and MCP IAI" and "apply polyarticular injection".
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Rita Nely Vilar
authors.initials: RN
authors.lastname: Furtado
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Flavia Soares
authors.initials: FS
authors.lastname: Machado
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Karine Rodrigues da
authors.initials: KR
authors.lastname: Luz
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marla Francisca dos
authors.initials: MF
authors.lastname: Santos
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Monique Sayuri
authors.initials: MS
authors.lastname: Konai
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Roberta Vilela
authors.initials: RV
authors.lastname: Lopes
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil. Electronic address: jnatour@unifesp.br.
authors.forename: Jamil
authors.initials: J
authors.lastname: Natour
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide
keywords: Arthritis rheumatoid; Artrite reumatoide; Infiltração; Injection; Predictions; Prognósticos; Triamcinolone hexacetonide; Triancinolona hexacetonida