title: Synthesis and evaluation of indole based molecules for treatment of oxidative stress related diseases.
abstract: The chemical versatility of the indole nucleus still inspires the pharmaceutical research to develop innovative suitable indole based drugs. The present work is an overview of the use and application of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan (Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active drugs for a simpler delivery to the patients.
authors.forename: Francesca
authors.initials: F
authors.lastname: Aiello
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, Via Borsari 46 - 44121 Ferrara, Italy. giuseppe.valacchi@unife.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Valacchi
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D007211:Indoles