title: p53 mutations and inflammation-associated cancer are linked through TNF signaling.
abstract: In this issue, Di Minin et al. (2014) link mutant p53 and chronic inflammation to tumorigenic progression via TNF signaling. Mutp53 interacts with the tumor suppressor DAB2IP in the cytoplasm, and induces a TNF-dependent transcriptional profile via NF-kB and JNK.
authors.affiliation: Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, 20892-4258, USA. Electronic address: tomer.cooks@nih.gov.
authors.forename: Tomer
authors.initials: T
authors.lastname: Cooks
authors.affiliation: Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, 20892-4258, USA.
authors.forename: Curtis C
authors.initials: CC
authors.lastname: Harris
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D020703:ras GTPase-Activating Proteins