title: Parvalbumin expression and distribution in the hippocampal formation of Cebus apella.
abstract: New World primates play an important role in biomedical research. However, the literature still lacks information on many structural features of the brain in these species, particularly structures of the hippocampal formation that are related to long-term memory storage. This study was designed to provide information, for the first time, about the distribution and number of neurons expressing parvalbumin-immunoreactivity (PV-I) in the subregions of the hippocampal formation in Cebus apella, a New World primate species commonly used in biomedical research. Our results revealed that for several morphometric variables, PV-I cells differ significantly among the subregions CA1, CA2, CA3, and the hilus. Based upon our findings and those of other studies, we hypothesize that the proportional increase from monkeys to humans in PV-I cell density within CA1 is a factor contributing to the evolution of increased memory formation and storage.
authors.affiliation: Universidade Federal de São Paulo, Unifesp/EPM, Departamento de Neurologia e Neurocirurgia, Laboratório de Neurociências, São Paulo, Brazil; Hospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo, Brazil; Instituto Evandro Chagas (IEC), Centro Nacional de Primatas (CENP), Ananindeua, Brazil.
authors.forename: Laila Brito
authors.initials: LB
authors.lastname: Torres
authors.forename: Bruno Henrique Silva
authors.initials: BH
authors.lastname: Araujo
authors.forename: Klena Sarges
authors.initials: KS
authors.lastname: Marruaz
authors.forename: Janaina Sena
authors.initials: JS
authors.lastname: de Souza
authors.forename: Bolivar Saldanha
authors.initials: BS
authors.lastname: Sousa
authors.forename: Sérgio
authors.initials: S
authors.lastname: Gomes da Silva
authors.forename: Francisco Romero
authors.initials: FR
authors.lastname: Cabral
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D000818:Animals; D002428:Cebus / Q000033:anatomy & histology / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D007395:Interneurons / Q000166:cytology / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*
chemical_list: D010320:Parvalbumins
keywords: CA2 layer; inhibitory interneurons; memory storage; new world primates; stereology