title: Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae.
abstract: Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms.
authors.affiliation: Department of Chemistry and Biochemistry, University of California Santa Cruz, California, 95064, USA. rliningt@ucsc.edu.
authors.forename: Christopher J A
authors.initials: CJ
authors.lastname: Warner
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Cheng
authors.forename: Fitnat H
authors.initials: FH
authors.lastname: Yildiz
authors.forename: Roger G
authors.initials: RG
authors.lastname: Linington
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development*; D015195:Drug Design; D010078:Oxazines / Q000737:chemistry* / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines