title: Regulation of the protein stability of EMT transcription factors.
abstract: The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.
authors.affiliation: a Programa de Recerca en Càncer ; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM); Parc de Recerca Biomèdica de Barcelona; Doctor Aiguader; Barcelona, Spain.
authors.forename: V M
authors.initials: VM
authors.lastname: Díaz
authors.forename: R
authors.initials: R
authors.lastname: Viñas-Castells
authors.forename: A
authors.initials: A
authors.lastname: García de Herreros
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D010641:Phenotype; D055550:Protein Stability; D015398:Signal Transduction; D000071250:Snail Family Transcription Factors; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases; C000604407:SNAI1 protein, human; C000604429:Snai1 protein, mouse
keywords: EMT; F-box; Snail1; hypoxia; proteasome; stress; ubiquitination