title: Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects.
abstract: OBJECTIVE
  To determine (1) the effects of weight loss in obese subjects on six adipokines and joint biomarkers; and (2) the relationship between changes in these markers with changes in cartilage outcomes.
  
  
  METHODS
  Plasma levels of adiponectin, leptin, IL-6, COMP, MMP-3 and urine levels of CTX-II were measured at baseline and 12 months from 75 obese subjects enrolled in two weight-loss programs. Magnetic resonance imaging (MRI) was used to assess cartilage volume and thickness. Associations between weight loss, cartilage outcomes and markers were adjusted for age, gender, baseline BMI, presence of clinical knee OA, with and without weight loss percent.
  
  
  RESULTS
  Mean weight loss was 13.0 ± 9.5%. Greater weight loss percentage was associated with an increase in adiponectin (β = 0.019, 95% CI 0.012 to 0.026,) and a decrease in leptin (β = -1.09, 95% CI -1.37 to -0.82). Multiple regression analysis saw an increase in adiponectin associated with reduced loss of medial tibial cartilage volume (β = 14.4, CI 2.6 to 26.3) and medial femoral cartilage volume (β = 18.1, 95% CI 4.4 to 31.8). Decrease in leptin was associated with reduced loss of medial femoral volume (β = -4.1, 95% CI -6.8 to -1.4) and lateral femoral volume (β = -1.8, 95% CI -3.7 to 0.0). When weight loss percent was included in the model, only the relationships between COMP and cartilage volume remained statistically significant.
  
  
  CONCLUSIONS
  Adiponectin and leptin may be associated with cartilage loss. Further work will determine the relative contributions of metabolic and mechanical factors in the obesity-related joint changes.
authors.affiliation: Sydney Medical School, The University of Sydney, Australia. Electronic address: laurenkarinaking@gmail.com.
authors.forename: L K
authors.initials: LK
authors.lastname: King
authors.affiliation: Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia. Electronic address: holger.henneicke@googlemail.com.
authors.forename: H
authors.initials: H
authors.lastname: Henneicke
authors.affiliation: Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia. Electronic address: markus.seibel@sydney.edu.au.
authors.forename: M J
authors.initials: MJ
authors.lastname: Seibel
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney, Australia; Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia. Electronic address: lyn.march@sydney.edu.au.
authors.forename: L
authors.initials: L
authors.lastname: March
authors.affiliation: Sydney Medical School, The University of Sydney, Australia; Department of Rheumatology, Concord Hospital, Sydney, Australia. Electronic address: anaananda@med.usyd.edu.au.
authors.forename: A
authors.initials: A
authors.lastname: Anandacoomarasmy
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D064236:Cartilage Oligomeric Matrix Protein / Q000378:metabolism; D002358:Cartilage, Articular / Q000473:pathology*; D015331:Cohort Studies; D024043:Collagen Type II / Q000652:urine; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007719:Knee Joint / Q000473:pathology*; D020738:Leptin / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D009929:Organ Size; D020370:Osteoarthritis, Knee / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010446:Peptide Fragments / Q000652:urine; D011446:Prospective Studies; D012044:Regression Analysis; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D015850:Interleukin-6; D020738:Leptin; D019278:Matrix Metalloproteinase 3; D010446:Peptide Fragments; C499918:ADIPOQ protein, human; C000590554:C-terminal cross-linking telopeptide of type II collagen, human; C508600:IL6 protein, human; C511768:MMP3 protein, human; C577553:TSP5 protein, human
keywords: Adipokines; Biomarkers; Cartilage; Knee osteoarthritis; Obesity