title: KO(t)Bu-mediated aerobic transition-metal-free regioselective β-arylation of indoles: synthesis of β-(2-/4-nitroaryl)-indoles.
abstract: A KO(t)Bu-mediated intermolecular oxidative C-C coupling of nitroarenes with indoles is presented in DMSO at room temperature in an open flask. By using this mild and economical methodology, syntheses of β-(2/4-nitroaryl)-indoles with sensitive functionalities such as bromo, iodo, cyano, and nitro were achieved chemo- and regioselectively. Synthesized β-(2/4-nitroaryl) indoles were transformed into densely functionalized biindoles, indoloindoles, and (4-aminoaryl)-indoles which demonstrate post-transformation utility of the developed methodology.
authors.affiliation: Department of Chemistry, IISER Bhopal , Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh, India -462 066.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Vandana
authors.initials: V
authors.lastname: Rathore
authors.forename: Ajay
authors.initials: A
authors.lastname: Verma
authors.forename: Ch Durga
authors.initials: ChD
authors.lastname: Prasad
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Yadav
authors.forename: Sadhan
authors.initials: S
authors.lastname: Jana
authors.forename: Moh
authors.initials: M
authors.lastname: Sattar
authors.lastname: Meenakshi
authors.forename: Sangit
authors.initials: S
authors.lastname: Kumar