title: Hepatic arterial infusion in hepatocellular carcinoma: a single center experience.
abstract: OBJECTIVE
  The aim of the present study was to evaluate a single center experience with hepatic arterial infusion (HAI) in patients with hepatocellular carcinoma.
  
  
  METHODS
  A retrospective analysis of 20 patients treated for hepatocellular carcinoma between 1994 and 2007.
  
  
  RESULTS
  Most patients were treated with an HAI of doxorubicin and cisplatin combined with 5-fluorouracil and folinic acid. The response was not evaluable in the majority of patients, predominantly because of associated surgical procedure or because only one cycle of HAI was administered. The median progression-free survival was 7.7 months. The median survival of all patients was 12.2 months (5-year survival 5%). Serious adverse events were observed in 5 patients, and one patient died of liver failure in association with the administration of HAI.
  
  
  CONCLUSIONS
  The data show the limited efficacy of HAI in patients with hepatocellular carcinoma.
authors.affiliation: Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Josef
authors.initials: J
authors.lastname: Dvorak
authors.forename: Alexander
authors.initials: A
authors.lastname: Ferko
authors.forename: Katerina
authors.initials: K
authors.lastname: Kamaradova
authors.forename: Antonin
authors.initials: A
authors.lastname: Krajina
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage*; D018153:Czech Republic / Q000453:epidemiology; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D014803:Vitamin B Complex; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil