title: Orbital immunoglobulin IgG4-related inflammatory fibrosclerosing lesion treated with pentoxifylline and α-tocopherol: case report.
abstract: Immunoglobulin G4 (IgG4)-related disease is a distinct group of disorders that are characterised by intense infiltration of an organ with IgG4(+) cells, subsequent inflammation, fibrosis, and masses. We report a new treatment of orbital IgG4-related disease with pentoxyphylline and α-tocopherol, both of which are anti-inflammatory and antifibrotic agents.
authors.affiliation: Head & Neck and Skull Base Surgery/Oncology Programme, Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Private Bag 31-907, High St, Lower Hutt, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Lee
authors.affiliation: Head & Neck and Skull Base Surgery/Oncology Programme, Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Private Bag 31-907, High St, Lower Hutt, New Zealand.
authors.forename: C A
authors.initials: CA
authors.lastname: MacKinnon
authors.affiliation: Department of Ophthalmology, Wellington Regional Hospital, Riddiford Street, Newtown, Wellington 6021, New Zealand.
authors.forename: N
authors.initials: N
authors.lastname: Aburn
authors.affiliation: Head & Neck and Skull Base Surgery/Oncology Programme, Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Private Bag 31-907, High St, Lower Hutt, New Zealand; Gillies McIndoe Research Institute, PO Box 7184, Newtown, Wellington 6242, New Zealand. Electronic address: swee.tan@gmri.org.nz.
authors.forename: S T
authors.initials: ST
authors.lastname: Tan
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001402:B-Lymphocytes / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000187:drug effects*; D008214:Lymphocytes / Q000473:pathology; D009916:Orbital Diseases / Q000188:drug therapy*; D016727:Orbital Pseudotumor / Q000188:drug therapy; D010431:Pentoxifylline / Q000627:therapeutic use*; D010950:Plasma Cells / Q000473:pathology; D012598:Sclerosis; D013601:T-Lymphocytes / Q000473:pathology; D024502:alpha-Tocopherol / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D007074:Immunoglobulin G; D024502:alpha-Tocopherol; D010431:Pentoxifylline
keywords: Fibrosclerotic; IgG(4); Orbital; Pentoxifylline; Vitamin E; α-Tocopherol