title: Captopril partially decreases the effect of H(2)S on rat blood pressure and inhibits H(2)S-induced nitric oxide release from S-nitrosoglutathione.
abstract: We studied the effects of the H(2)S donor Na(2)S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na(2)S (1-4 micromol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 micromol/kg, Na(2)S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H(2)S influences MAP and heart and breathing rates. The effect of Na(2)S in decreasing MAP was less pronounced in the presence of captopril (2 micromol/l), which may indicate that the renin-angiotensin system is partially involved in the Na(2)S effect. Captopril decreased H(2)S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H(2)S. These results contribute to the understanding of the effects of H(2)S on the cardiovascular system.
authors.affiliation: Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic, Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic. karol.ondrias@savba.sk.
authors.forename: M
authors.initials: M
authors.lastname: Drobná
authors.forename: A
authors.initials: A
authors.lastname: Misak
authors.forename: T
authors.initials: T
authors.lastname: Holland
authors.forename: F
authors.initials: F
authors.lastname: Kristek
authors.forename: M
authors.initials: M
authors.lastname: Grman
authors.forename: L
authors.initials: L
authors.lastname: Tomasova
authors.forename: A
authors.initials: A
authors.lastname: Berenyiova
authors.forename: S
authors.initials: S
authors.lastname: Cacanyiova
authors.forename: K
authors.initials: K
authors.lastname: Ondrias
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology*; D002216:Captopril / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004347:Drug Interactions; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D056152:Respiratory Rate / Q000502:physiology / Q000528:radiation effects; D026422:S-Nitrosoglutathione / Q000378:metabolism*; D013440:Sulfides / Q000008:administration & dosage
chemical_list: D013440:Sulfides; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D002216:Captopril; C033479:sodium sulfide; D006862:Hydrogen Sulfide