title: Photothermal effects and toxicity of Fe3O4 nanoparticles via near infrared laser irradiation for cancer therapy.
abstract: The photothermal effect of magnetite (Fe3O4) nanoparticles was characterized by photonic absorption in the near-infrared (NIR) region. Upon laser irradiation at 785 nm, the Fe3O4 nanoparticles generate localized hyperthermia in tumorous lesions, which is an effective strategy for cancer therapy; however, uncoated magnetite possesses an innate toxicity which can lead to drawbacks in the clinical setting. To reduce innate toxicity, a poly(acrylic acid) (PAA) coating on the nanoparticles was investigated in order to determine the alterations to stability and the degree of toxicity in an attempt to create a higher utility vector. It was found that the PAA coating significantly reduced the innate toxicity of the uncoated magnetite. Furthermore, the efficacy of PAA-coated magnetite nanoparticles (PAA-Fe3O4) was investigated for treating MDA-MB-231 (human mammary gland adenocarcinoma) cultures in viable concentration ranges (0.1-0.5mg/ml). An appropriate PAA-Fe3O4 concentration range was then established for inducing significant cell death by hyperthermic ablation, but not through innate toxicity.
authors.affiliation: The Materials Science and Engineering Program, Dept. of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Dunn
authors.affiliation: Department of Physics, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Sadat M
authors.initials: SM
authors.lastname: Ehsan
authors.affiliation: Department of Physics, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: David
authors.initials: D
authors.lastname: Mast
authors.affiliation: The James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA.
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Pauletti
authors.affiliation: Nano Biomedical Research Center, School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Geological & Environmental Sciences, Stanford University, Stanford, CA 94305, USA.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Geological & Environmental Sciences, Stanford University, Stanford, CA 94305, USA.
authors.forename: Rodney C
authors.initials: RC
authors.lastname: Ewing
authors.affiliation: The Materials Science and Engineering Program, Dept. of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA; Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China. Electronic address: donglu.shi@uc.edu.
authors.forename: Donglu
authors.initials: D
authors.lastname: Shi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007259:Infrared Rays; D007834:Lasers; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy; D010789:Phototherapy
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; C006903:carbopol 940
keywords: Cancer therapy; Hyperthermia; Nanomedicine; Nanotechnology; Photothermal effect