title: [Illicit drug use by pregnant women infected with HIV].
abstract: OBJECTIVE
  To determine if illicit drug use increases the vertical transmission of HIV, to identify the risk factors involved in mother and child health and the prevalence of illicit drug use among these pregnant women.
  
  
  METHODS
  Sixty-four (7.6%) of 845 pregnant women from the metropolitan region of Belo Horizonte, Minas Gerais, Brazil, attended in the service between October 1997 and February 2012 reported the use of illicit drugs. Cases were HIV-positive drug users (n=64) and controls were women who did not use drugs (n=192). Three controls were selected for each case. Several conditions of exposure were considered in the control group such as tobacco use, alcohol use, alcohol and tobacco use, maternal age, educational level, ethnicity, and marital status. Problems during the prenatal period, delivery and postpartum, vertical HIV transmission and neonatal outcomes were also investigated.
  
  
  RESULTS
  Univariate analysis showed as significant variables: maternal age, tobacco use, number of prenatal care visits, antiretroviral therapy, mode of infection, and viral load at delivery. Logistic regression revealed as significant variables: maternal age (less than 25 years); tobacco use, and number of prenatal care visits (less than 6). The vertical transmission of HIV was 4,8% (95%CI 1.7-13.3) among drug users and 2,1% (95%CI 0.8-5.2) in the control group, with no statistically significant difference between groups. Neonatal complications were more frequent among drug users, but also with no statistically significant difference between groups.
  
  
  CONCLUSIONS
  The use of illicit drug is frequent during pregnancy among HIV-infected women. The approach to illicit drug use should be routine during prenatal care visits. These women are more discriminated against and tend to deny their habits or do not seek prenatal care. There was no difference in vertical virus transmission between groups, probably indicating adherence to antiretroviral use for antiretroviral therapies during pregnancy.
authors.affiliation: Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Melo
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.
authors.forename: Ana Paula Machado
authors.initials: AP
authors.lastname: Botelho
authors.affiliation: Grupo de Pesquisa em HIV Materno/Infantil, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.
authors.forename: Marcelle Marie Martins
authors.initials: MM
authors.lastname: Maia
authors.affiliation: Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.
authors.forename: Mário Dias
authors.initials: MD
authors.lastname: Correa
authors.affiliation: Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.
authors.forename: Jorge Andrade
authors.initials: JA
authors.lastname: Pinto
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015995:Prevalence; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D013287:Illicit Drugs