title: The role of proteases in regulating Eph/ephrin signaling.
abstract: Proteases regulate a myriad of cell functions, both in normal and disease states. In addition to protein turnover, they regulate a range of signaling processes, including those mediated by Eph receptors and their ephrin ligands. A variety of proteases is reported to directly cleave Ephs and/or ephrins under different conditions, to promote receptor and/or ligand shedding, and regulate receptor/ligand internalisation and signaling. They also cleave other adhesion proteins in response to Eph-ephrin interactions, to indirectly facilitate Eph-mediated functions. Proteases thus contribute to Eph/ephrin mediated changes in cell-cell and cell-matrix interactions, in cell morphology and in cell migration and invasion, in a manner which appears to be tightly regulated by, and co-ordinated with, Eph signaling. This review summarizes the current literature describing the function and regulation of protease activities during Eph/ephrin-mediated cell signaling.
authors.affiliation: a Department of Biochemistry and Molecular Biology ; Monash University , Victoria ; Australia.
authors.forename: Lakmali
authors.initials: L
authors.lastname: Atapattu
authors.forename: Martin
authors.initials: M
authors.lastname: Lackmann
authors.forename: Peter W
authors.initials: PW
authors.lastname: Janes
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D036342:Ephrins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism*; D011485:Protein Binding; D036081:Receptors, Eph Family / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D036342:Ephrins; D008024:Ligands; D036081:Receptors, Eph Family; D010447:Peptide Hydrolases
keywords: AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, Amyloid precursor protein; Arf1, ADP rybosylation factor 1; BACE, β-site APP cleaving enzyme; CAM, cell adhesion molecules; CTF, cytoplasmic fragment; CNC, cranial neural crest; ECM, ; ADAM; Eph receptor tyrosine kinase; MMP; ephrin signaling; protease; γ-secretase