title: Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer diagnosis and staging.
abstract: Lung cancer is one of the most prevalent types of cancer in the world. A complete diagnosis of lung cancer involves tissue acquisition for pathological subtype, molecular diagnosis and accurate staging of the disease to guide appropriate therapy. Real-time endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is minimally invasive and relatively safe procedure, which can be done on an outpatient basis under moderate sedation. EBUS-TBNA has been shown to be a safe modality to obtain tissue for diagnosis, staging and molecular profiling in lung cancer. EBUS-TBNA stands out in comparison with other modalities for tissue acquisition in lung cancer. EBUS-TBNA performed with the patient under moderate sedation yields sufficient tissue for sequential molecular analysis in most patients. In this review, we describe the role of EBUS-TBNA in various aspects of diagnosis and staging of lung cancer in the present era along with its future aspects.
authors.affiliation: Institute of Pulmonology, Medical Research and Development, Mumbai, India.
authors.forename: Preyas J
authors.initials: PJ
authors.lastname: Vaidya
authors.forename: Arvind H
authors.initials: AH
authors.lastname: Kate
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yasufuku
authors.forename: Prashant N
authors.initials: PN
authors.lastname: Chhajed
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D020680:Bronchoscopes; D001999:Bronchoscopy / Q000295:instrumentation; D016292:Procedural Sedation; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D025202:Molecular Diagnostic Techniques; D009367:Neoplasm Staging; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor
keywords: CP-EBUS; EBUS-TBNA; diagnosis; endobronchial ultrasound; lung cancer; molecular analysis; re-staging; staging; technical aspects