title: Chitosan as a sustainable organocatalyst: a concise overview.
abstract: Increased demand for more sustainable materials and chemical processes has tremendously advanced the use of polysaccharides, which are natural biopolymers, in domains such as adsorption, catalysis, and as an alternative chemical feedstock. Among these biopolymers, the use of chitosan, which is obtained by deacetylation of natural chitin, is on the increase due to the presence of amino groups on the polymer backbone that makes it a natural cationic polymer. The ability of chitosan-based materials to form open-network, macroporous, high-surface-area hydrogels with accessible basic surface sites has enabled their use not only as macrochelating ligands for active metal catalysts and as a support to disperse nanosized particles, but also as a direct organocatalyst. This review provides a concise overview of the use of native and modified chitosan, possessing different textural properties and chemical properties, as organocatalysts. Organocatalysis with chitosan is primarily focused on carbon-carbon bond-forming reactions, multicomponent heterocycle formation reactions, biodiesel production, and carbon dioxide fixation through [3+2] cycloaddition. Furthermore, the chiral, helical organization of the chitosan skeleton lends itself to use in enantioselective catalysis. Chitosan derivatives generally display reactivity similar to homogeneous bases, ionic liquids, and organic and inorganic salts. However, the introduction of cooperative acid-base interactions at active sites substantially enhances reactivity. These functional biopolymers can also be easily recovered and reused several times under solvent-free conditions. These accomplishments highlight the important role that natural biopolymers play in furthering more sustainable chemistry.
authors.affiliation: Euro-Med Research Institute, Engineering Division, Euro-Mediterranean University of Fes (UEMF), Fès Shore, Route de Sidi Hrazem, 30070 Fès (Morocco). a.elkadib@ueuromed.org.
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: El Kadib
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D048271:Chitosan / Q000737:chemistry*; D003247:Conservation of Natural Resources / Q000379:methods*
chemical_list: D048271:Chitosan
keywords: biomass; chitosan; heterogeneous catalysis; organocatalysis; sustainable chemistry