title: Combined early dynamic (18)F-FDG PET/CT and conventional whole-body (18)F-FDG PET/CT provide one-stop imaging for detecting hepatocellular carcinoma.
abstract: OBJECTIVE
  It is widely accepted that conventional (18)F-FDG PET/CT (whole-body static (18)F-FDG PET/CT, WB (18)F-FDG PET/CT) has a low detection rate for hepatocellular carcinoma (HCC). We prospectively assessed the role of early dynamic (18)F-FDG PET/CT (ED (18)F-FDG PET/CT) and WB (18)F-FDG PET/CT in detecting HCC, and we quantified the added value of ED (18)F-FDG PET/CT to WB (18)F-FDG PET/CT.
  
  
  METHODS
  Twenty-two patients with 37 HCC tumors (HCCs) who underwent both a liver ED (18)F-FDG PET/CT (performed simultaneously with a 5.5 MBq/kg (18)F-FDG bolus injection and continued for 240 s) and a WB (18)F-FDG PET/CT were enrolled in the study.
  
  
  RESULTS
  The WB (18)F-FDG PET/CT and ED (18)F-FDG PET/CT scans were positive in 56.7% (21/37) and 78.4% (29/37) HCCs, respectively (P<0.05). ED (18)F-FDG PET/CT in conjunction with WB (18)F-FDG PET/CT (one-stop (18)F-FDG PET/CT) improved the positive detection rates of WB and ED (18)F-FDG PET/CT alone from 56.7% and 78.4% to 91.9% (34/37) (P<0.001 and P>0.05, respectively).
  
  
  CONCLUSIONS
  One-stop (18)F-FDG PET/CT appears to be useful to improve WB (18)F-FDG PET/CT for HCC detection.
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Radiology, First People's Hospital of Yunnan Province, Kunming, China. Electronic address: wshbo_98@163.com.
authors.forename: Shao-Bo
authors.initials: SB
authors.lastname: Wang
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Hu-Bing
authors.initials: HB
authors.lastname: Wu
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: wqslph@163.net.
authors.forename: Quan-Shi
authors.initials: QS
authors.lastname: Wang
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Wen-Lan
authors.initials: WL
authors.lastname: Zhou
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Li
authors.affiliation: Department of Radiology, First People's Hospital of Yunnan Province, Kunming, China.
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Ji
authors.affiliation: Department of Radiology, First People's Hospital of Yunnan Province, Kunming, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18