title: CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron.
abstract: Sensory adaptation represents a form of experience-dependent plasticity that allows neurons to retain high sensitivity over a broad dynamic range. The mechanisms by which sensory neuron responses are altered on different timescales during adaptation are unclear. The threshold for temperature-evoked activity in the AFD thermosensory neurons (T*(AFD)) in C. elegans is set by the cultivation temperature (T(c)) and regulated by intracellular cGMP levels. We find that T*(AFD) adapts on both short and long timescales upon exposure to temperatures warmer than T(c), and that prolonged exposure to warmer temperatures alters expression of AFD-specific receptor guanylyl cyclase genes. These temperature-regulated changes in gene expression are mediated by the CMK-1 CaMKI enzyme, which exhibits T(c)-dependent nucleocytoplasmic shuttling in AFD. Our results indicate that CaMKI-mediated changes in sensory gene expression contribute to long-term adaptation of T*(AFD), and suggest that similar temporally and mechanistically distinct phases may regulate the operating ranges of other sensory neurons.
authors.affiliation: Department of Biology, National Center for Behavioral Genomics Brandeis University Waltham, MA 02454.
authors.forename: Yanxun V
authors.initials: YV
authors.lastname: Yu
authors.affiliation: Department of Biology, National Center for Behavioral Genomics Brandeis University Waltham, MA 02454.
authors.forename: Harold W
authors.initials: HW
authors.lastname: Bell
authors.affiliation: Department of Biology University of Fribourg Fribourg 1700, Switzerland.
authors.forename: Dominique
authors.initials: D
authors.lastname: Glauser
authors.affiliation: Department of Biology, National Center for Behavioral Genomics Brandeis University Waltham, MA 02454.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Van Hooser
authors.affiliation: Department of Molecular and Cellular Physiology Stanford University School of Medicine Palo Alto, CA 94305.
authors.forename: Miriam B
authors.initials: MB
authors.lastname: Goodman
authors.affiliation: Department of Biology, National Center for Behavioral Genomics Brandeis University Waltham, MA 02454.
authors.forename: Piali
authors.initials: P
authors.lastname: Sengupta
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003198:Computer Simulation; D006152:Cyclic GMP / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism*; D008959:Models, Neurological; D009154:Mutation / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D011601:Psychophysics; D011984:Sensory Receptor Cells / Q000502:physiology*; D013696:Temperature; D013697:Thermosensing / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D049452:Green Fluorescent Proteins; D019950:Mitogen-Activated Protein Kinase 1; D006152:Cyclic GMP; D002118:Calcium