title: Unprecedented dinuclear silver(I)-mediated base pair involving the DNA lesion 1,N(6)-ethenoadenine.
abstract: The DNA lesion 1,N(6)-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA : εA mispair readily forms doubly silver(I)-mediated base pairs εA-Ag(I)2-εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
authors.affiliation: Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstr. 28/30, 48149 Münster, Germany. mueller.j@uni-muenster.de.
authors.forename: Soham
authors.initials: S
authors.lastname: Mandal
authors.forename: Alexander
authors.initials: A
authors.lastname: Hepp
authors.forename: Jens
authors.initials: J
authors.lastname: Müller
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D020029:Base Pairing; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012834:Silver / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: C004981:1,N(6)-ethenoadenine; D012834:Silver; D004247:DNA; D000225:Adenine