title: NMR hyperpolarization techniques for biomedicine.
abstract: Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo molecular imaging modalities, ranging from functional imaging of the lungs to metabolic imaging of cancer. This Concept article explores selected advances in methods for the preparation and use of hyperpolarized contrast agents, many of which are already at or near the phase of their clinical validation in patients.
authors.affiliation: Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University, 1161 21st Ave South AA-1107, Nashville, Tennessee, 37232-2310 (USA).
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Nikolaou
authors.forename: Boyd M
authors.initials: BM
authors.lastname: Goodson
authors.forename: Eduard Y
authors.initials: EY
authors.lastname: Chekmenev
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: dynamic nuclear polarization; hyperpolarization; medicinal chemistry; molecular imaging; spin exchange optical pumping