title: Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature.
abstract: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a newly recognized entity caused by monoclonal deposition of IgG. PGNMID resembles immune complex glomerulonephritis (GN) on light and electron microscopy. The monotypic immunoglobulin deposits seen on immunofluorescence (IF) clinches the diagnosis. We report a case of proliferative GN associated MGRS and review the relevant literature. The patient had significant proteinuria and elevated serum creatinine. The renal biopsy showed proliferative GN with focal crescents and monoclonal immune deposits confirming a diagnosis of PGNMID. Serum work up showed no monoclonal proteins. Proliferative GN as a manifestation of a monoclonal gammopathy needs to be borne in mind especially in renal biopsies of older patients.
authors.affiliation: Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India.
authors.forename: R
authors.initials: R
authors.lastname: Fatima
authors.affiliation: Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India.
authors.forename: R
authors.initials: R
authors.lastname: Jha
authors.affiliation: Department of Histopathology, Apollo Hospitals, Hyderabad, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Gowrishankar
authors.affiliation: Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Narayen
authors.affiliation: Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Rao
keywords: Monoclonal immune deposits; immunofluorescence; outcome; proliferative glomerulonephritis