title: Treating prolactinoma can prevent autoimmune diseases.
abstract: Prolactin (PRL) is a pleiotropic hormone; in addition to a wide variety of endocrine effects, PRL also exhibits immunostimulating effects. Therefore, there is increasing evidence linking PRL with a large number of systemic and organ specific autoimmune diseases. Herein, we report the case of an adolescent girl diagnosed with multiple sclerosis (MS) occurring in the context of untreated prolactinoma evolving since childhood. This raises the exciting question of the involvement of PRL in the pathogenesis of MS. It is likely that early treatment of hyperprolactinemia in this case would have significantly reduced the risk of developing MS or even prevented its occurrence.
authors.affiliation: Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Abdulla
authors.initials: A
authors.lastname: Watad
authors.affiliation: Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis, Nice, France; Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Versini
authors.affiliation: Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis, Nice, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Jeandel
authors.affiliation: Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: Howard
authors.initials: H
authors.lastname: Amital
authors.affiliation: Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis, Nice, France; Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: shoenfel@post.tau.ac.il.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000077465:Cabergoline; D002648:Child; D004873:Ergolines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000628:therapy; D009103:Multiple Sclerosis / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000150:complications / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D004873:Ergolines; D011388:Prolactin; D000077465:Cabergoline
keywords: Autoimmune disease; Autoimmunity; Bromocriptine; Cabergoline; Hormones; Multiple sclerosis; Prolactin; Prolactinoma