title: Eco-friendly aqueous core surface-modified nanocapsules.
abstract: In this work, positively charged nanocapsules have been developed for potential ocular delivery exploiting the deposition of PLA onto the droplet surface of a W/O nanoemulsion prepared by the reversed procedure of the PIT method. PLA in combination with different amounts of various oils and surfactants have been studied in order to select the best formulation for polymeric nanocapsule preparation. The traditional visual observation together with the Turbiscan(®) technology were exploited in order to identify the best combination of polymer/oil for nanocapsule preparation. Two different primary surfactants (Span(®) 60 and Span(®) 80) have been tested to select their influence on the field of existence of the nanoemulsion by the construction of the pseudoternary phase diagrams. Cationic hybrid NC have been prepared by the addition of a coating layer of DDAB. The physico-chemical and morphological properties of all the prepared nanocapsules have been evaluated and compared by PCS, DSC and AFM. Therefore, positively charged nanocapsules can be easily prepared by a simple eco-friendly technique that exploits biocompatible materials avoiding a large input of mechanical energy as a potential ocular delivery systems for hydrophilic compounds or gene materials.
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy. Electronic address: ccarbone@unict.it.
authors.forename: C
authors.initials: C
authors.lastname: Carbone
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy. Electronic address: teresa.musumeci@unict.it.
authors.forename: T
authors.initials: T
authors.lastname: Musumeci
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Lauro
authors.affiliation: Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Puglisi
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D055772:Green Chemistry Technology; D006601:Hexoses / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009822:Oils, Volatile / Q000737:chemistry*; D044367:Phase Transition; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D055672:Static Electricity; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D006601:Hexoses; D053769:Nanocapsules; D009822:Oils, Volatile; D011091:Polyesters; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C018665:sorbitan monooleate; C046112:didodecyldimethylammonium; D019344:Lactic Acid; C033616:poly(lactide); C009298:sorbitan monostearate
keywords: Cationic lipid; Cationic nanoparticles; Hybrid nanoparticles; Ocular delivery; PLA; Turbiscan