title: Prevalence of chronic rhinosinusitis in the setting of Behçet disease.
abstract: Behçet disease (BD) is a systemic autoimmune/autoinflammatory, T helper 1-mediated condition. It is well known that the prevalence of a T helper 1-mediated disease increases in the presence of another T helper 1-mediated comorbidity. The purpose of this study was to investigate the prevalence of T helper 1-mediated chronic rhinosinusitis without nasal polyposis (CRSsNP) and T helper 2-mediated chronic rhinosinusitis with polyposis in the presence of comorbid BD. Sixty-nine patients and 74 healthy controls were included in the study. Participants were asked to complete a questionnaire for symptoms of rhinosinusitis. Nasal cavities were scored using the Lund-Kennedy endoscopy scores. Paranasal sinus computed tomography imagings were scored according to Lund-Mackay radiology scores. Skin prick tests were carried out for all participants to determine the predisposing role of allergy (T helper 2 disease) in the etiopathogenesis of rhinosinusitis among patients and controls. Patients' endoscopy, radiology, and skin prick testing scores were evaluated with regard to BD activity.The prevalence of CRSsNP was 23.2 % in BD and 2.7% in normal population. The CRSsNP was more frequently seen in patients than in the healthy controls (P = 0.002). The BD patients displayed worse scores on their left sinonasal endoscopy. No statistically significant difference was seen between BD and control groups with regard to Lund-Mackay radiology scores of both sides. The presence of an allergic response to a specific allergen in skin-prick testing were confirmed in 25 patients (36.2%) and 17 controls (23.0%). However, the difference was not statistically significant. There were positive responses to more allergens when BD activity was reduced.The CRSsNP thought to be of T helper 1-mediated origin was more frequently seen in the presence of comorbid BD.
authors.affiliation: From the Departments of *Otorhinolaryngology/Head and Neck Surgery and †Dermatology, Haydarpaşa Numune Educational and Research Hospital, Istanbul; ‡Department of Otorhinolaryngology/Head and Neck Surgery, Edirne State Hospital, Edirne; §Department of Otorhinolaryngology/Head and Neck Surgery, Bağcılar Medipol Hospital, Istanbul; ∥Department of Otorhinolaryngology/Head and Neck Surgery, Medical Park Hospital, Gebze; and ¶Department of Otorhinolaryngology/Head and Neck Surgery, Ünye State Hospital, Ünye, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Verim
authors.forename: Filiz
authors.initials: F
authors.lastname: Cebeci
authors.forename: Engin
authors.initials: E
authors.lastname: Başer
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Çalim
authors.forename: Dinçer
authors.initials: D
authors.lastname: Kadioğlu
authors.forename: Gamze Didem
authors.initials: GD
authors.lastname: Kocagöz
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012220:Rhinitis / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D012852:Sinusitis / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D012882:Skin Tests / Q000379:methods; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014057:Tomography, X-Ray Computed; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult