title: Flexible organic electrochemical transistors for highly selective enzyme biosensors and used for saliva testing.
abstract: Flexible organic electrochemical transistors (OECTs) are successfully used as high-performance enzyme biosensors, such as uric acid (UA) and cholesterol sensors. The sensitivity and selectivity of the sensors can be simultaneously enhanced by co-modifying the gate electrodes with positively/negatively charged bilayer polymer films and enzymes. These OECT-based UA sensors are successfully utilized for non-invasive UA detection in human saliva.
authors.affiliation: Department of Applied Physics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Caizhi
authors.initials: C
authors.lastname: Liao
authors.forename: Chunhin
authors.initials: C
authors.lastname: Mak
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Helen L W
authors.initials: HL
authors.lastname: Chan
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004563:Electrochemistry; D004566:Electrodes; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012463:Saliva / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry; D014173:Transistors, Electronic; D014503:Urate Oxidase / Q000737:chemistry / Q000378:metabolism; D014527:Uric Acid / Q000032:analysis* / Q000737:chemistry
chemical_list: D004800:Enzymes, Immobilized; D009930:Organic Chemicals; D011093:Polyethylene Terephthalates; D011137:Polystyrenes; D013876:Thiophenes; C533756:poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate); D014527:Uric Acid; D010984:Platinum; D006861:Hydrogen Peroxide; D014503:Urate Oxidase
keywords: biosensors; enzymes; organic electrochemical transistors; selectivity; uric acid