title: [Squamous cell carcinoma in localized scleroderma].
abstract: We present a case of a young 26-year-old woman, who has been suffering from localised scleroderma (morphea) for 15 years. Recently, a lesion on the dorsum of her right foot ulcerated. Based on a CT scan and X-ray a diagnosis of ulcerative osteomyellitis was established. The patient was treated with a combination of antibiotics. Subsequent histological examinations showed granulomatous tissue and chronic inflammatory changes on top of pseudoepiteliomatous hyperplasia. The patients status was deteriorating, which resulted in a limb amputation under the knee. Three months later, there was a metastasis of squamous cell carcinoma found in the patients inguinal lymph node. In spite of combined therapy (surgery, radioterapy and systemic chemotherapy), new metastases occurred and the patient succumbed to the disease several months afterwards. The case was concluded as a squamous cell carcinoma camouflaged by osteomyelitis. Malignant turn of localised sclerodema is very rare. It usually occurs on the lower extremities of patients with a long course of the disease and is associated with pansclerotic or generalised variants of morphea.
authors.forename: V
authors.initials: V
authors.lastname: Durčanská
authors.forename: H
authors.initials: H
authors.lastname: Jedličková
authors.forename: O
authors.initials: O
authors.lastname: Sláma
authors.forename: L
authors.initials: L
authors.lastname: Velecký
authors.forename: E
authors.initials: E
authors.lastname: Březinová
authors.forename: V
authors.initials: V
authors.lastname: Vašků
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D016523:Foot Ulcer / Q000209:etiology / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000628:therapy; D011859:Radiography; D012594:Scleroderma, Localized / Q000150:complications*; D012878:Skin Neoplasms / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents