title: Toxicokinetics and tissue distribution of prothioconazole in male adult Sprague-Dawley rats following a single oral administration.
abstract: 1. Prothioconazole (PTC) is a new type of triazolinthione fungicide used worldwide. Despite its widespread use, the basic toxicokinetics (TK) information for health risk assessments of PTC is limited. 2. TK behavior and metabolism studies of PTC were performed in male adult Sprague Dawley (SD) rats after a single oral administration. Serial blood and tissue samples were analyzed for their PTC content by high-performance liquid chromatography (HPLC) to obtain comprehensive time-course data for estimation of TK parameters. 3. PTC was rapidly but incompletely absorbed from the gastrointestinal tract of fasted adult rats. It was widely distributed in all parts of body, but demonstrated little tendency to accumulate. And PTC was excreted mainly in the form of parent compound. 4. The detection of PTC in brain and testis proved that further investigations are required to determine whether PTC could result in neurotoxicity and male reproductive toxicity.
authors.affiliation: Department of Toxicology, State Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Lingling
authors.initials: L
authors.lastname: Dai
authors.forename: Sihua
authors.initials: S
authors.lastname: Wei
authors.forename: Guihong
authors.initials: G
authors.lastname: Cheng
authors.forename: Long
authors.initials: L
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000737:chemistry; D008297:Male; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014018:Tissue Distribution; D066007:Toxicokinetics; D014230:Triazoles / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D014230:Triazoles; C550005:prothioconazole
keywords: HPLC; prothioconazole; tissue distribution; toxicokinetics; triazolinthione fungicide