title: Effect of liver regeneration on malignant hepatic tumors.
abstract: Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications.
authors.affiliation: Ji-Hua Shi, Pål-Dag Line, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway.
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Shi
authors.affiliation: Ji-Hua Shi, Pål-Dag Line, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway.
authors.forename: Pål-Dag
authors.initials: PD
authors.lastname: Line
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects*; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000473:pathology; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary / Q000601:surgery*; D008115:Liver Regeneration; D061206:Neoplasm Micrometastasis; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction; D013997:Time Factors; D016896:Treatment Outcome; D059016:Tumor Microenvironment
keywords: Colorectal cancer; Epithelial to mesenchymal transition; Hepatic progenitor cell; Hepatocellular carcinoma; Liver regeneration; Recurrence