title: MicroRNA-124 modulates social behavior in frontotemporal dementia.
abstract: Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.
authors.affiliation: Center for Neurodegeneration and Experimental Therapeutics, Departments of Neurology and Neurobiology, Birmingham, Alabama, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arrant
authors.affiliation: Center for Neurodegeneration and Experimental Therapeutics, Departments of Neurology and Neurobiology, Birmingham, Alabama, USA.
authors.forename: Erik D
authors.initials: ED
authors.lastname: Roberson
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005625:Frontal Lobe / Q000378:metabolism*; D057180:Frontotemporal Dementia / Q000235:genetics*; D035683:MicroRNAs / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism*; D012919:Social Behavior
chemical_list: C525139:CHMP2B protein, mouse; D056827:Endosomal Sorting Complexes Required for Transport; D035683:MicroRNAs; C540079:Mirn124 microRNA, mouse; D009419:Nerve Tissue Proteins; D018091:Receptors, AMPA