title: Vertebro-basilar junction aneurysms: a single centre experience and meta-analysis of endovascular treatments.
abstract: Vascular lesions of the vertebrobasilar junction (VBJ) are challenging in neurosurgical practice, and their gold-standard therapy is still under debate. We describe the operative strategies currently in use for the management of these complex vascular lesions and discuss their rationale in a literature meta-analysis and single centre blinded retrospective study. The single centre study included a review of initial presentation, angiographic features and clinical outcome (with modified Rankin Scale [mRS] scores) over a long-term follow-up. In our series, small aneurysms were effectively treated by endosaccular coil embolization, whereas a strategy including flow-diverter devices combined with endosaccular coil embolization was the option of choice in large and giant aneurysms, leading to satisfactory outcomes in most cases. Our Medline review showed that endovascular treatment was chosen in most VBJ cases, whereas the microsurgical option was assigned to only a few cases. Among the endovascular treatments, the most common techniques used for the treatment of VBJ aneurysms were: coiling, stent-assisted coiling and flow diversion. Our study highlights that aneurysm morphology, location and patient-specific angio-architecture are key factors to be considered in the management of VBJ aneurysms. Most case series, including our own, show that parent artery reconstruction using a flow-diverter device is a feasible and successful technique in some cases of giant and complex aneurysms (especially those involving the lower third of the basilar artery) while a "sit back, wait and see" approach may represent the safest and most reasonable option.
authors.affiliation: Neurosurgical Clinic, "P. Giaccone" University Hospital, Palermo University Palermo; Palermo, Italy - franeurosurgery@libero.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Graziano
authors.affiliation: Graduate School of Biomedical Engineering, University of Cagliari; Cagliari, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Ganau
authors.affiliation: Neurosurgical Clinic, "P. Giaccone" University Hospital, Palermo University Palermo; Palermo, Italy.
authors.forename: Domenico Gerardo
authors.initials: DG
authors.lastname: Iacopino
authors.affiliation: Department of Neuroradiology, Niguarda Ca' Grande Institution; Milan, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Boccardi
mesh_terms: D000328:Adult; D000368:Aged; D002533:Cerebral Angiography / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods*; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery / Q000628:therapy*; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D015607:Stents; D016896:Treatment Outcome
keywords: endovascular treatment; flow diverter; giant aneurysms; vertebrobasilar junction