title: Tinzaparin provides lower lipid profiles in maintenance hemodialysis patients: a cross-sectional observational study.
abstract: As a low-molecular-weight heparin, tinzaparin has effectively been used as an anticoagulant during hemodialysis sessions. However, the impact of different heparin types on dyslipidemia is still controversial. In our study, 434 chronic hemodialysis patients were evaluated. The mean age was 65 ± 13. Forty-eight patients (11%) and 386 patients (89%) were in the tinzaparin and unfractionated heparin (UFH) groups, respectively. Triglyceride had significant difference between the two groups (P = 0.001) but total cholesterol, HDL, or LDL did not. In the univariate analysis, the triglyceride level was significantly associated with tinzaparin use [β: -39.9, 95% confidence interval (CI): -76.7 to -3.0], and this association remained following the multivariate analysis (β: -40.8, 95% CI: -75.1 to -6.5). The difference in serum total cholesterol level between tinzaparin and UFH became significant (β: -13, 95% CI: -24.5 to -1.56) after adjustment in the multivariate analysis. Moreover, in a subgroup analysis, male diabetic patients showed lower serum triglyceride levels with the use of tinzaparin, while older, nondiabetic, male patients showed significant advantages in total cholesterol levels with the use of tinzaparin. Based on our findings, tinzaparin shows a significant association with a lower lipid profile in patients with chronic hemodialysis when compared to UFH.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan ; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Hsu Chow Road, Zhongzheng District, Taipei 100, Taiwan.
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Tsai
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Fang
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, No. 95 Wen-Chang Road, Shih-Lin District, Taipei 111, Taiwan ; Fu-Jen Catholic University School of Medicine, No. 510 Zhongzheng Road, Xinzhuang District, New Taipei City 24205, Taiwan.
authors.forename: Jyh-Gang
authors.initials: JG
authors.lastname: Leu
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003710:Demography; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D006435:Renal Dialysis; D000078222:Tinzaparin; D014280:Triglycerides / Q000097:blood
chemical_list: D006495:Heparin, Low-Molecular-Weight; D008055:Lipids; D014280:Triglycerides; D000078222:Tinzaparin; D002784:Cholesterol