title: Synthesis of oxidant prone nanosilver to develop H2O2 responsive drug delivery system.
abstract: Our immune system uses toxicity of hydrogen peroxide to kill off bacterial invaders. In this contribution, we intended to integrate ROS producing capability of immune system with oxidant-sensitive nature of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant drug delivery system. Prior to execute this strategy, we have developed an efficient one-pot synthetic protocol to produce ultrasmall (5 nm), water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized Ag NPs is 10-fold higher than standard citrate reduction route. The resulting therapeutically active and well-dispersed Ag NPs are used as nanolids to cap the drug loaded nanochannels of porous silica. Upon exposing to H2O2, dissolution-accompanied aggregation of Ag nanolids unleashes the encapsulated therapeutic entities from channels of nanocarrier. Combination of antibacterial and anti-inflammatory drugs in single nanocarriers can potentially augment the effectiveness of various therapies.
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, ‡China Japan Union Hospital, and §State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, China.
authors.forename: Faheem
authors.initials: F
authors.lastname: Muhammad
authors.forename: Aifei
authors.initials: A
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Miao
authors.forename: Pengyuan
authors.initials: P
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Jianshi
authors.initials: J
authors.lastname: Du
authors.forename: Guangshan
authors.initials: G
authors.lastname: Zhu
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D016877:Oxidants; D009569:Nitric Oxide; D012834:Silver; D012822:Silicon Dioxide; D006861:Hydrogen Peroxide