title: Purloined mechanisms of bacterial immunity can cure muscular dystrophy.
abstract: Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes muscular dystrophy (Long et al., 2014).
authors.affiliation: Molecular, Cellular and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, CA 90095-7239, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1732, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095-7239, USA. Electronic address: jtidball@lifesci.ucla.edu.
authors.forename: James G
authors.initials: JG
authors.lastname: Tidball
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: Bertoni
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics*; D004195:Disease Models, Animal; D016189:Dystrophin / Q000235:genetics*; D051379:Mice; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics* / Q000628:therapy; D009154:Mutation
chemical_list: D016189:Dystrophin