title: [Studying of the role of tumor necrosis factor-alpha in regulation of erythropoiesis in erythroblastic islands cultures].
abstract: An elevated level of tumor necrosis factor-alpha in a cultural system of bone marrow erythroblastic islands was found. It was associated with the suppressed formation of erythroblastic islands de repeto in 24-hr cultures. In 48-hr cultures, an increased level of erythropoietin and intensive formation of erythroblastic islands de repeto and de novo was found. In 72-hr cultures, further elevation of TNF-alpha was accompanied by a decrease of erythroblastic islands in culture.
authors.forename: S A
authors.initials: SA
authors.lastname: Shevyakov
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Zakharov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D002478:Cells, Cultured; D004900:Erythroblasts / Q000378:metabolism*; D004920:Erythropoiesis / Q000235:genetics*; D004921:Erythropoietin / Q000378:metabolism*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D004921:Erythropoietin