title: Synthesis of 2,3-Dihydro-1H-2-benzazepin-1-ones and 3H-2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors.
abstract: A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini condensation and intramolecular Wittig reaction in the presence of NEt3.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.forename: Zhi-Lin
authors.initials: ZL
authors.lastname: Ren
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Ding
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012492:Salts / Q000737:chemistry
chemical_list: D001552:Benzazepines; D003486:Cyanides; D009943:Organophosphorus Compounds; D012492:Salts