title: Ehealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome.
abstract: OBJECTIVE
  To investigate the effects of a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols diet (LFD) and the probiotic Lactobacillus rhamnosus GG (LGG) in irritable bowel syndrome (IBS).
  
  
  METHODS
  Randomised, unblinded controlled trial on the effect of 6-wk treatment with LFD, LGG or a normal Danish/Western diet (ND) in patients with IBS fulfilling Rome III diagnostic criteria, recruited between November 2009 and April 2013. Patients were required to complete on a weekly basis the IBS severity score system (IBS-SSS) and IBS quality of life (IBS-QOL) questionnaires in a specially developed IBS web self-monitoring application. We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.
  
  
  RESULTS
  One hundred twenty-three patients (median age 37 years, range: 18-74 years), 90 (73%) females were randomised: 42 to LFD, 41 to LGG and 40 to ND. A significant reduction in mean ± SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed: 133 ± 122 vs 68 ± 107, 133 ± 122 vs 34 ± 95, P < 0.01. Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND (IBS-SSS score 75; 95%CI: 24-126, P < 0.01), but not in LGG compared to ND (IBS-SSS score 32; 95%CI: 18-80, P = 0.20). IBS-QOL was not altered significantly in any of the three groups: mean ± SD in LFD 8 ± 18 vs LGG 7 ± 17, LFD 8 ± 18 vs ND 0.1 ± 15, P = 0.13.
  
  
  CONCLUSIONS
  Both LFD and LGG are efficatious in patients with IBS.
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Natalia
authors.initials: N
authors.lastname: Pedersen
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Nynne Nyboe
authors.initials: NN
authors.lastname: Andersen
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Végh
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Jensen
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Dorit Vedel
authors.initials: DV
authors.lastname: Ankersen
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Maria
authors.initials: M
authors.lastname: Felding
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Mette Hestetun
authors.initials: MH
authors.lastname: Simonsen
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Johan
authors.initials: J
authors.lastname: Burisch
authors.affiliation: Natalia Pedersen, Johan Burisch, Pia Munkholm, Digestive Disease Centre, Medical Section, Herlev University Hospital, 2730 Copenhagen, Denmark.
authors.forename: Pia
authors.initials: P
authors.lastname: Munkholm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003718:Denmark; D050528:Diet, Carbohydrate-Restricted; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005240:Feasibility Studies; D005260:Female; D005285:Fermentation; D006801:Humans; D020407:Internet; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000178:diet therapy* / Q000378:metabolism / Q000382:microbiology; D052201:Lacticaseibacillus rhamnosus / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010352:Patient Dropouts; D019936:Probiotics / Q000627:therapeutic use*; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates
keywords: Disease severity; Irritable bowel syndrome; Irritable bowel syndrome-quality of life; Lactobacillus rhamnosus GG; Low FODMAP diet; Web-based management