title: HMGA1-pseudogene overexpression contributes to cancer progression.
abstract: Two pseudogenes for HMGA1, whose overexpression has a critical role in cancer progression, have been identified. They act as decoy for miRNAs that are able to target the HMGA1 gene then enhancing cell proliferation and migration. Moreover, these pseudogenes contain sequences that are potential target sites for cancer-related miRNAs. Interestingly, HMGA1 pseudogenes are highly expressed in human anaplastic thyroid carcinomas, that is one of the most aggressive tumor in mankind, but almost undetectable in well differentiated thyroid carcinomas.
authors.affiliation: a Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli ; Università degli Studi di Napoli "Federico II," ; Naples , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Esposito
authors.forename: Marco
authors.initials: M
authors.lastname: De Martino
authors.forename: Floriana
authors.initials: F
authors.lastname: Forzati
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D024003:HMGA Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011544:Pseudogenes / Q000502:physiology*
chemical_list: D024003:HMGA Proteins; D035683:MicroRNAs