title: In vitro bioactivity and mechanical properties of bioactive glass nanoparticles/polycaprolactone composites.
abstract: Nanoparticles of bioactive glass (NBG) with a diameter of 50-90 nm were synthesized using the Stöber method. NBG/PCL composites with different NBG contents (0 wt.%, 10 wt.%, 20 wt.%, 30 wt.% and 40 wt.%) were prepared by a melt blending and thermal injection moulding technique, and characterized with XRD, FTIR, and SEM to study the effect of NBG on the mechanical properties and in vitro bioactivity of the NBG/PCL composites. In spite of the high addition up to 40 wt.%, the NBG could be dispersed homogeneously in the PCL matrix. The elastic modulus of the NBG/PCL composites was improved remarkably from 198±13 MPa to 851±43 MPa, meanwhile the tensile strength was retained in the range of 19-21.5 MPa. The hydrophilic property and degradation behavior of the NBG/PCL composites were also improved with the addition of the NBG. Moreover, the composites with high NBG content showed outstanding in vitro bioactivity after being immersed in simulated body fluid, which could be attributed to the excellent bioactivity of the synthesized NBG.
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China. Electronic address: ljji@yzu.edu.cn.
authors.forename: Lijun
authors.initials: L
authors.lastname: Ji
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Yangzhou University, Yangzhou 225002, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Jin
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Song
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D055119:Elastic Modulus; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone
keywords: Bioactive glass nanoparticles; Bioactivity; Mechanical properties; Polycaprolactone composites