title: Synthesis and biological applications of phosphinates and derivatives.
abstract: This review first outlines general considerations on phosphinic acids and derivatives as bioisosteric groups. The next sections present key aspects of phosphinic acid-based molecules and include a brief description of the biological pathways involved for their activities. The synthetic aspects and the biological activities of such compounds reported in the literature between 2008 and 2013 are also described.
authors.affiliation: UMR 5253 - ICG Montpellier, Equipe AM2N, ENSCM, 8, rue de l'Ecole, Normale, 34296, Montpellier Cedex 5, France, david.virieux@enscm.fr.
authors.forename: David
authors.initials: D
authors.lastname: Virieux
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Volle
authors.forename: Norbert
authors.initials: N
authors.lastname: Bakalara
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pirat
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000963:Antimetabolites / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D018757:GABA Modulators / Q000138:chemical synthesis / Q000494:pharmacology; D006540:Herbicides / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D010721:Phosphinic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D010756:Phosphoric Acids / Q000737:chemistry; D006109:Poaceae / Q000187:drug effects / Q000254:growth & development; D013237:Stereoisomerism
chemical_list: D000890:Anti-Infective Agents; D000963:Antimetabolites; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002264:Carboxylic Acids; D004337:Drug Carriers; D018691:Excitatory Amino Acid Antagonists; D018757:GABA Modulators; D006540:Herbicides; D010721:Phosphinic Acids; D010756:Phosphoric Acids