title: Coronary artery disease and plasma apolipoprotein E4 in mild cognitive impairment.
abstract: BACKGROUND
  Atherosclerosis and apolipoprotein E4 (APOE4) are known risks for Dementia. We sought to evaluate the relationship between coronary atherosclerosis and APOE4 with mild cognitive impairment (MCI).
  
  
  METHODS
  In a case-control study, subjects with age more than 60 years and recent coronary angiography were evaluated by mini-mental state examination and neuropsychiatry unit cognitive assessment tool (NUCOG) to find the patients with MCI (n = 40) and the controls with normal cognition (n = 40). Coronary angiography records were re-assessed to find the severity of coronary artery disease by the Gensini scores. Plasma levels of APOE4 were measured.
  
  
  RESULTS
  There were no-significant difference between the 2 groups regarding the plasma APOE4 levels (P = 0.706) and the Gensini scores (P = 0.236). Associations between the Gensini scores and the NUCOG scores in the MCI group (r = -0.196, P = 0.225) and the control group (r = 0.189, P = 0.243) were not significant. However, the interaction effect between the Gensini and the NUCOG scores based on allocation to the control or the patient groups showed statistically significant difference (F(1,67) = 4.84, P = 0.031).
  
  
  CONCLUSIONS
  Although atherosclerosis has been considered as known risk factor for dementia and MCI, this study could not reveal that coronary atherosclerosis-related to declining in cognitive functioning. There was no significant association between plasma APOE4 levels and MCI.
authors.affiliation: Associate Professor, Psychosomatic Research Center AND Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Barekatain
authors.affiliation: Resident, Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Zahedian
authors.affiliation: Resident, Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hedyeh
authors.initials: H
authors.lastname: Askarpour
authors.affiliation: Associate Professor, Department of Epidemiology and Biostatistics AND Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Maracy
authors.affiliation: Associate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi-Jazi
authors.affiliation: Isfahan Center of Health Research, Isfahan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Aghaye-Ghazvini
keywords: Angiography; Apolipoprotein E4; Coronary Artery; Mild Cognitive Impairment