title: A multifunctional β-CD-modified Fe3O4@ZnO:Er(3+),Yb(3+) nanocarrier for antitumor drug delivery and microwave-triggered drug release.
abstract: We constructed a novel core-shell structured Fe3O4@ZnO:Er(3+),Yb(3+)@(β-CD) nanoparticles used as drug carrier to investigate the loading and controllable release properties of the chemotherapeutic drug etoposide (VP-16). The cavity of β-cyclodextrin is chemically inert, it can store etoposide molecules by means of hydrophobic interactions. The Fe3O4 core and ZnO:Er(3+),Yb(3+) shell functioned successfully for magnetic targeting and up-conversion fluorescence imaging, respectively. In addition, the ZnO:Er(3+),Yb(3+) shell acts as a good microwave absorber with excellent microwave thermal response property for microwave triggered drug release (the VP-16 release of 18% under microwave irradiation for 15 min outclass the 2% within 6h without microwave irradiation release). The release profile could be controlled by the duration and number of cycles of microwave application. This material therefore promises to be a useful noninvasive, externally controlled drug-delivery system in cancer therapy.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Peng
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China. Electronic address: cuibin@nwu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Li
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Yingsai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Nini
authors.initials: N
authors.lastname: Li
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Zhuguo
authors.initials: Z
authors.lastname: Chang
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
authors.forename: Yaoyu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D004871:Erbium / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008872:Microwaves; D015018:Ytterbium / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D047392:beta-Cyclodextrins; C000499:ferric oxide; D004871:Erbium; D015018:Ytterbium; D015034:Zinc Oxide
keywords: Controlled drug release; Fe(3)O(4)@ZnO:Er(3+),Yb(3+)@(β-CD); Magnetic properties; Microwave-triggered; Up-conversion luminescence