title: Study on fibrous materials for brain phantoms.
abstract: Generally, current clinical imaging methods do not provide highly detailed information about location of axonal injury, severity of injury or expected recovery of patients with traumatic brain injury (TBI). High-Definition Fiber Tractography (HDFT) is a novel imaging modality that allows visualizing and quantifying, directly, the degree of axons damage, predicting functional deficits due to traumatic axonal injury and loss of cortical projections. This imaging modality is based on diffusion technology. Being a novel modality, validation and quality control are essential. Thus this study aims at the development of a brain phantom to mimic the human brain in order to fill some gaps that currently exist in this area. This paper is focused on this novel imaging approach, the role of brain phantoms on its validation and the quality control, as well as, on the materials used in their construction. Furthermore, some important characteristics of fibrous materials for brain phantom are also discussed.
authors.affiliation: University of Minho, Guimarães, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Guise
authors.affiliation: University of Minho, Guimarães, Portugal.
authors.forename: Raul
authors.initials: R
authors.lastname: Fangueiro
authors.affiliation: University of Minho, Guimarães, Portugal.
authors.forename: João Miguel
authors.initials: JM
authors.lastname: Nóbrega
authors.affiliation: University of Pittsburgh, Pennsylvania, United States of America.
authors.forename: Walter
authors.initials: W
authors.lastname: Schneider
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D000070642:Brain Injuries, Traumatic / Q000000981:diagnostic imaging*; D056324:Diffusion Tensor Imaging / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008422:Materials Testing; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D066127:White Matter / Q000000981:diagnostic imaging* / Q000293:injuries / Q000473:pathology