title: A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer.
abstract: Cyclin A2 is a promising cancer prognostic indicator, but its intracellular in situ imaging is still a challenging task. This work designs an "off-on" fluorescent probe, which can fluorescently detect intracellular cyclin A2 and distinguish cancer cells. In addition, this work sheds light on the development of future protein biosensors.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Ji
authors.forename: Yijia
authors.initials: Y
authors.lastname: Guan
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Daisuke
authors.initials: D
authors.lastname: Miyoshi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056751:Cyclin A2 / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008856:Microscopy, Fluorescence; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis; D012235:Rhodamines / Q000737:chemistry / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D056751:Cyclin A2; D005456:Fluorescent Dyes; D012235:Rhodamines; D012822:Silicon Dioxide; D006108:Graphite; C029773:rhodamine B