title: [Pathophysiological changes of umbilical vessels in intrauterine growth restriction].
abstract: BACKGROUND
  The prevalence of intrauterine growth restriction is 4-5000/100,000 births, and they give the majority of perinatal morbidity.
  
  
  OBJECTIVE
  The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies.
  
  
  METHODS
  Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists' protocol.
  
  
  RESULTS
  After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups.
  
  
  CONCLUSIONS
  The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight.
authors.affiliation: Szegedi Tudományegyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Szeged Semmelweis u. 1. 6725.
authors.forename: Mária
authors.initials: M
authors.lastname: Jakó
authors.affiliation: Szegedi Tudományegyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Szeged Semmelweis u. 1. 6725.
authors.forename: Andrea
authors.initials: A
authors.lastname: Surányi
authors.affiliation: Szegedi Tudományegyetem, Általános Orvostudományi Kar Patológiai Intézet Szeged.
authors.forename: László
authors.initials: L
authors.lastname: Kaiser
authors.affiliation: Szegedi Tudományegyetem, Gyógyszerésztudományi Kar Biofarmáciai és Gyógyszerhatástani Intézet Szeged.
authors.forename: Dóra
authors.initials: D
authors.lastname: Domokos
authors.affiliation: Szegedi Tudományegyetem, Gyógyszerésztudományi Kar Biofarmáciai és Gyógyszerhatástani Intézet Szeged.
authors.forename: Róbert
authors.initials: R
authors.lastname: Gáspár
authors.affiliation: Szegedi Tudományegyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Szeged Semmelweis u. 1. 6725.
authors.forename: György
authors.initials: G
authors.lastname: Bártfai
mesh_terms: D001724:Birth Weight; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000473:pathology / Q000503:physiopathology; D014470:Umbilical Cord / Q000098:blood supply* / Q000503:physiopathology*; D014471:Umbilical Veins / Q000473:pathology / Q000503:physiopathology
keywords: intrauterine growth restriction; köldökzsinór; köldökzsinórerek; méhen belüli fejlődési visszamaradás; umbilical cord; umbilical vessels; vessel tone