title: Renal water molecular diffusion characteristics in healthy native kidneys: assessment with diffusion tensor MR imaging.
abstract: BACKGROUND
  To explore the characteristics of diffusion tensor imaging (DTI) and magnetic resonance (MR) imaging in healthy native kidneys.
  
  
  METHODS
  Seventy-three patients without chronic kidney disease underwent DTI-MRI with spin echo-echo planar (SE-EPI) sequences accompanied by an array spatial sensitivity encoding technique (ASSET). Cortical and medullary mean, axial and radial diffusivity (MD, AD and RD), fractional anisotropy (FA) and primary, secondary and tertiary eigenvalues (λ1, λ2, λ3) were analysed in both kidneys and in different genders.
  
  
  RESULTS
  Cortical MD, λ2, λ3, and RD values were higher than corresponding medullary values. The cortical FA value was lower than the medullary FA value. Medullary λ1 and RD values in the left kidney were lower than in the right kidney. Medullary λ2, and λ3 values in women were higher than those in men. Medullary FA values in women were lower than those in men. Medullary FA (r = 0.351, P = 0.002) and λ1 (r = 0.277, P = 0.018) positively correlated with eGFR. Medullary FA (r = -0.25, P = 0.033) negatively correlated with age.
  
  
  CONCLUSIONS
  Renal water molecular diffusion differences exist in human kidneys and genders. Age and eGFR correlate with medullary FA and primary eigenvalue.
authors.affiliation: Department of Nephrology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Radiology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
authors.forename: Huilan
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Radiology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
authors.forename: Yunting
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate; D064368:Healthy Volunteers; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014867:Water
chemical_list: D014867:Water