title: Chromatin modification by the RNA Polymerase II elongation complex.
abstract: Transcription elongation by RNA polymerase II (RNAP II) involves the coordinated action of numerous regulatory factors. Among these are chromatin-modifying enzymes, which generate a stereotypic and conserved pattern of histone modifications along transcribed genes. This pattern implies a precise coordination between regulators of histone modification and the RNAP II elongation complex. Here I review the pathways and molecular events that regulate co-transcriptional histone modifications. Insight into these events will illuminate the assembly of functional RNAP II elongation complexes and how the chromatin landscape influences their composition and function.
authors.affiliation: a Department of Pharmacology and Therapeutics ; McGill University ; Montreal , Canada.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Tanny
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D012319:RNA Polymerase II / Q000378:metabolism*; D035602:Transcriptional Elongation Factors / Q000378:metabolism*; D000095043:Cyclin-Dependent Kinase-Activating Kinase
chemical_list: D002843:Chromatin; D006657:Histones; D035602:Transcriptional Elongation Factors; D018844:Cyclin-Dependent Kinases; D012319:RNA Polymerase II; D000095043:Cyclin-Dependent Kinase-Activating Kinase; C000722416:CDK7 protein, human
keywords: Cdk7; Cdk9; H3K4 methylation; histone H2B ubiquitylation; histone modifications; transcription elongation