title: Betatrophin--promises fading and lessons learned.
abstract: The discovery of a potent mitogen for insulin-producing pancreatic β cells, optimistically termed "betatrophin," excited researchers and laypeople alike, promising a new therapeutic approach to diabetes. A recent "Matters Arising" report by Gusarova and colleagues (2014) places serious doubts on whether "betatrophin" plays any major role in β cell replication.
authors.affiliation: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: kaestner@mail.med.upenn.edu.
authors.forename: Klaus H
authors.initials: KH
authors.lastname: Kaestner
mesh_terms: D042682:Angiopoietins / Q000378:metabolism*; D000818:Animals; D050417:Insulin-Secreting Cells / Q000166:cytology*; D008297:Male
chemical_list: D042682:Angiopoietins