title: Severe retinopathy following radiation therapy with a moderate dose for orbital mucosa-associated lymphoid tissue lymphoma.
abstract: Mucosa-associated lymphoid tissue (MALT) lymphoma is a radiosensitive malignancy. We report on a case of severe retinopathy following radiation therapy with a moderate dose for orbital MALT lymphoma. A 69-year-old woman with orbital MALT lymphoma received definitive radiation therapy with a total dose of 36 Gy in 18 fractions. The patient showed complete response but had severe retinopathy along with marked deterioration in visual acuity at 2 years after irradiation. Although the patient underwent treatments for retinopathy, including laser photocoagulation and steroid injection, improvement of the visual acuity was modest. This case developed severe radiation-induced retinopathy after radiation therapy with the moderate dose of 36 Gy that is considered to be usually safe.
authors.affiliation: Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hata
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kaneko
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000368:Aged; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007834:Lasers; D008028:Light Coagulation; D018442:Lymphoma, B-Cell, Marginal Zone / Q000532:radiotherapy*; D009092:Mucous Membrane / Q000528:radiation effects; D009915:Orbit / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012160:Retina / Q000528:radiation effects*; D012164:Retinal Diseases / Q000209:etiology*; D013256:Steroids / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D013256:Steroids
keywords: mucosa-associated lymphoid tissue lymphoma; orbital lymphoma; radiation therapy; retinopathy; visual acuity