title: Cytotoxicity evaluation of a new set of 2-aminobenzo[de]iso-quinoline-1,3-diones.
abstract: A new series of 2-amino-benzo[de]isoquinoline-1,3-diones was synthesized and fully characterized in our previous paper. Here, their cytotoxic effects have been evaluated in vitro in relation to colon HCT-116, hepatocellular Hep-G2 and breast MCF-7 cancer cell lines, using a crystal violet viability assay. The IC50-values of the target compounds are reported in µg/mL, using doxorubicin as a reference drug. The findings revealed that compounds 14, 15, 16, 21 and 22 had significant cytotoxic effects against HCT-116, MCF-7 and Hep-G2 cell lines. Their IC50 values ranged between 1.3 and 8.3 μg/mL in relation to doxorubicin (IC50 ≈ 0.45-0.89 μg/mL). Therefore, these compounds could be used as templates for furthering the development and design of more potent antitumor agents through structural modification.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ralsalahi@ksu.edu.sa.
authors.forename: Rashad
authors.initials: R
authors.lastname: Al-Salahi
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ialsuwidan@ksu.edu.sa.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Alswaidan
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. mohmarzouk@ksu.edu.sa.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Marzouk
mesh_terms: D016923:Cell Death / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D011804:Quinolines; C037219:quinoline