title: In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey.
abstract: Staphylococcus species are one of the major causes of bacterial bloodstream infections. Multi-resistant staphylococci infections are major therapeutic problems. This study was aimed to detect methicillin, linezolid and vancomycin susceptibilities of Staphylococcus isolates. A total of 870 Staphylococcus strains isolated from blood cultures of hospitalized patients with BSI. Antimicrobial susceptibilities of methicillin, linezolid and vancomycin were detected according to the Clinical and Laboratory Standards Institute (CLSI). A total of 771 (88.6%) isolates were coagulase-negative staphylococci (CoNS). 700 (80.5%) isolates were methicillin-resistant (MR) and 170 (19.5%) were methicillin-susceptible (MS). All the MS isolates were also susceptible to linezolid. However 15 (1.7%) of MR strains were resistant to linezolid. The minimum inhibitory concentration range for the linezolid-resistant isolates by Etest was 6-32 μg/mL. The difference between linezolid susceptibilities for MS and MR staphylococci was not quite statistically significant (p = 0.052). There was no statistically significant difference between S. aureus and CoNS isolates for linezolid susceptibility. All of the isolates were susceptible to vancomycin. In conclusion, linezolid is currently an efficient option for the treatment of methicillin-resistant staphylococci infections.
authors.affiliation: Department of Microbiology and Clinical Microbiology Medical Faculty Dicle University Diyarbakir Turkey Department of Microbiology and Clinical Microbiology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Alicem
authors.initials: A
authors.lastname: Tekin
authors.affiliation: Department of Microbiology and Clinical Microbiology Medical Faculty Dicle University Diyarbakir Turkey Department of Microbiology and Clinical Microbiology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Dal
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases Medical Faculty Dicle University Diyarbakir Turkey Department of Clinical Microbiology and Infectious Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Deveci
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases Medical Faculty Dicle University Diyarbakir Turkey Department of Clinical Microbiology and Infectious Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Tekin
authors.affiliation: Department of Microbiology and Clinical Microbiology Medical Faculty Dicle University Diyarbakir Turkey Department of Microbiology and Clinical Microbiology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Nida
authors.initials: N
authors.lastname: Özcan
authors.affiliation: Department of Microbiology and Clinical Microbiology Medical Faculty Dicle University Diyarbakir Turkey Department of Microbiology and Clinical Microbiology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Atmaca
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases Medical Faculty Dicle University Diyarbakir Turkey Department of Clinical Microbiology and Infectious Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Saim
authors.initials: S
authors.lastname: Dayan
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D018805:Sepsis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014421:Turkey; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D008712:Methicillin
keywords: Staphylococcus; linezolid; methicillin; vancomycin