title: Cortical thinning in individuals with subjective memory impairment.
abstract: Elderly individuals with subjective memory impairment (SMI) report memory decline, but perform within the age-, gender-, and education- adjusted normal range on neuropsychological tests. Longitudinal studies indicate SMI as a risk factor or early sign of Alzheimer's disease (AD). There is increasing evidence from neuroimaging that at the group level, subjects with SMI display evidence of AD related pathology. This study aimed to determine differences in cortical thickness between individuals with SMI and healthy control subjects (CO) using the FreeSurfer environment. 110 participants (41 SMI/69 CO) underwent structural 3D-T1 MR imaging. Cortical thickness values were compared between groups in predefined AD-related brain regions of the medial temporal lobe, namely the bilateral entorhinal cortex and bilateral parahippocampal cortex. Cortical thickness reduction was observed in the SMI group compared to controls in the left entorhinal cortex (p = 0.003). We interpret our findings as evidence of early AD-related brain changes in persons with SMI.
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany.
authors.forename: Dix
authors.initials: D
authors.lastname: Meiberth
authors.affiliation: Department of Radiology, University of Bonn, Bonn, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Scheef
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Wolfsgruber
authors.affiliation: Department of Radiology, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Boecker
authors.affiliation: Department of Radiology, University of Bonn, Bonn, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Block
authors.affiliation: Department of Radiology, University of Bonn, Bonn, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Träber
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Charitéplatz, Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Erk
authors.affiliation: German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany Department of Neurology, University of Bonn, Bonn, Germany Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Bonn, Germany.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Heneka
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Jacobi
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Spottke
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Charitéplatz, Berlin, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Walter
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000473:pathology*; D008875:Middle Aged
keywords: Alzheimer's disease; cortical thickness; entorhinal cortex; parahippocampal cortex; subjective cognitive decline; subjective memory impairment