title: Pseudo-continuous arterial spin labeling reflects vascular density and differentiates angiomatous meningiomas from non-angiomatous meningiomas.
abstract: Pseudo-continuous arterial spin labeling (PCASL) can measure tumor blood flow (TBF) reliably. We investigated meningioma TBF using PCASL and assessed for any correlation with histopathological microvascular density (MVD) and the World Health Organization (WHO) classification. Conventional MRI with contrast T1-weighted images and PCASL were acquired with a 3 T scanner before surgery in 25 consecutive patients with meningiomas. Using the PCASL perfusion map, the mean and maximum TBF were calculated from regions of interest placed in the largest cross-sectional plane of each tumor. Tissue sections from 16 patients were stained with CD31 to evaluate MVD and were assigned a WHO classification. The TBFs were statistically compared with MVD and the histopathological meningioma subtypes. There were 16 meningothelial meningiomas, four angiomatous meningiomas, two fibrous meningiomas, one transitional meningioma, and two atypical meningiomas. We observed significant correlation between MVD and both mean and maximum TBF (p < 0.05). The mean and maximum TBF ((mean)TBF, (max)TBF) in angiomatous meningiomas are significantly higher than that in non-angiomatous meningiomas (p < 0.05). PCASL is useful in assessing meningioma vascularity, and in differentiating angiomatous meningiomas from non-angiomatous meningiomas.
authors.affiliation: Department of Neurosurgery, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu, Shizuoka, 433-8558, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Koizumi
authors.forename: Naoto
authors.initials: N
authors.lastname: Sakai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaji
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takehara
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamashita
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Baba
authors.forename: Hisaya
authors.initials: H
authors.lastname: Hiramatsu
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sameshima
authors.forename: Hiroki
authors.initials: H
authors.lastname: Namba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002560:Cerebrovascular Circulation / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply* / Q000473:pathology*; D008579:Meningioma / Q000098:blood supply* / Q000473:pathology*; D008875:Middle Aged; D013113:Spin Labels
chemical_list: D013113:Spin Labels