title: Synthesis, characterization and fungicidal activity of binary and ternary metal(II) complexes derived from 4,4'-((4-nitro-1,2-phenylene) bis(azanylylidene))bis(3-(hydroxyimino)pentan-2-one).
abstract: Ternary copper(II) and binary copper(II), nickel(II) and cobalt(II) complexes derived from 4,4'-((4-nitro-1,2-phenylene)bis(azanylylidene))bis(3-(hydroxyimino)pentan-2-one) (H2L) were synthesized and characterized by elemental and thermal analyses, IR, UV-Vis. and (1)H NMR spectroscopy, conductivity and magnetic moments measurements. The analytical and spectral data showed that, the ligand acts as dibasic tetradentate or dibasic hexadentate bonding to the metal ion via the two-imine nitrogen, two nitrogen and/or oximato oxygen atoms of deprotonated oxime groups forming five and/or six rings including the metal ions. The complexes adopt either tetragonal distorted octahedral or square planar geometry around metal ions. The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and having an axial symmetry type of a d(x2-y2) ground state. The g values confirmed the geometry is elongated tetragonal octahedral geometry with considerably ionic or covalent environment. The antifungal biological activity of the prepared compounds was studied using well diffusion method. The obtained results showed that, the ligand is biologically inactive while its metal complexes were more potent fungicides than the ligand and standard antifungal drug (Amphotericin B).
authors.affiliation: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt. Electronic address: asaeltabl@yahoo.com.
authors.forename: Abdou S
authors.initials: AS
authors.lastname: El-Tabl
authors.affiliation: Department of Chemistry, Faculty of Science and Arts, Khulais, King Abdulaziz University, Saudi Arabia; Inorganic Chemistry Department, National Research Centre, P.O. 12311, Dokki, Cairo, Egypt.
authors.forename: Mohamad M E
authors.initials: MM
authors.lastname: Shakdofa
authors.affiliation: Inorganic Chemistry Department, National Research Centre, P.O. 12311, Dokki, Cairo, Egypt.
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Whaba
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010422:Pentanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D008670:Metals; D010422:Pentanones; D012545:Schiff Bases
keywords: Antifungal; Complexes; Oxime; Schiff base; Spectroscopic studies; Synthesis