title: Synthesis, spectral, thermal and biological studies on N(-)(2,4-dinitro-phenyl)-2-mercaptoacetohydrazide and its metal complexes.
abstract: Complexes of VO(2+), Cr(3+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+) and Hg(2+) ions with N(-)(2,4-dinitrophenyl)-2-mercaptoacetohydrazide (H2L) have been prepared and characterized on the basis of elemental analysis, molar conductance, thermal (TGA, DTGA), spectral (IR, NMR, UV-Visible, MS) and magnetic measurements. The IR spectra show that H2L behaves in a mononegative and/or binegative bidentate manner. The sulfate bridged the two complex molecules in [Cu(HL)(H2O)2(½SO4)]⋅3H2O. The acetate functions as a monodentate in [Ni(HL)(OAc)(H2O)3] and [Cr(HL)(OAc)2(H2O)(EtOH)]. Different stereochemistries are proposed: octahedral for Cr(III), Ni(II), Hg(II) and [Cu(HL)(H2O)2(SO4)0.5]⋅3H2O, square-based pyramid for [VO(HL)2]⋅EtOH, square-planar for [Co(L)(EtOH)(H2O)]⋅H2O, [Cu(L)(H2O)2] and tetrahedral for [Zn(L)(EtOH)(H2O)], [Cd(L)(EtOH)(H2O)] and [Cu2(HL)(H2O)6]Cl3⋅H2O according to the data of electronic spectra and magnetic measurements. The TGA data support the formula and indicate the outer and inner solvents as well as the final residue. The thermodynamic parameters are calculated using the Coats-Redfern and Horowitz-Metzger methods. H2L and [Zn(L)(EtOH)(H2O)] showed the highest cytotoxic activity while H2L has a higher antioxidant activity than ascorbic acid. The ionization constant of the ligand and the stability constant of the Cu(II)H2L in absence and presence of hexamine buffer were calculated.
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt; Chemistry Department, Faculty of Science, Kuwait University, Kuwait. Electronic address: aelasmy@yahoo.com.
authors.forename: A A
authors.initials: AA
authors.lastname: El-Asmy
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors.forename: T H
authors.initials: TH
authors.lastname: Rakha
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors.forename: M H
authors.initials: MH
authors.lastname: Abdel-Rhman
authors.affiliation: Chemistry Department, Industrial Education College, Beni-Suef University, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Hassanien
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors.forename: A S
authors.initials: AS
authors.lastname: Al-Mola
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013816:Thermodynamics
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D003603:Cytotoxins; D006834:Hydrazines; D013438:Sulfhydryl Compounds; C014949:acetylhydrazine
keywords: Complexes; Cytotoxic and antioxidant activity; Mercaptoacetohydrazide; Solution chemistry; Spectra; Thermal analysis