title: Chemokines as relay signals in human dendritic cell migration: serum amyloid A kicks off chemotaxis.
abstract: Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration-based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et al. [Eur. J. Immunol. 2015. 45: 101-112] show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte-derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1α for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia and Humanitas Clinical and Research Institute, Rozzano, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
authors.forename: Annalisa
authors.initials: A
authors.lastname: Del Prete
mesh_terms: D054405:Chemokine CCL3 / Q000276:immunology*; D003713:Dendritic Cells / Q000187:drug effects*; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology*; D009000:Monocytes / Q000187:drug effects*; D000685:Serum Amyloid A Protein / Q000494:pharmacology*
chemical_list: C515429:CCL3 protein, human; D054405:Chemokine CCL3; D016209:Interleukin-8; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein
keywords: Chemokines; Chemotaxis; Dendritic cells; Migration; Monocytes; Serum amyloid A