title: Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial.
abstract: BACKGROUND
  Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions.
  
  
  METHODS
  This study was designed as a randomized double-blind placebo-controlled cross-over trial. A total of 30 obese dyslipidemic subjects were assigned to curcuminoids (1 g/day) or placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for another 4 weeks. Serum sdLDL was measured at baseline and weeks 4, 6, and 10 of the trial.
  
  
  RESULTS
  Supplementation with curcuminoids (1 g/day) did not cause any significant alteration in serum sdLDL (P > 0.05).
  
  
  CONCLUSIONS
  Four-week supplementation with curcuminoids was not associated with any significant alteration in circulating sdLDL concentrations.
authors.affiliation: Associate Professor, Cardiovascular Research Center AND Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.affiliation: Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Yazdandoust
authors.affiliation: Assistant Professor, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.affiliation: Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mazidi
authors.affiliation: Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sharghi-Shahri
authors.affiliation: Professor, Brighton and Sussex Medical School, Mayfield House, University of Brighton, Brighton, UK.
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
authors.affiliation: Associate Professor, Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
keywords: Atherosclerosis; Cardiovascular Disease; Curcuma longa L.; Diferuloylmethane; Hypercholesterolemia; Turmeric