title: [Synthesis of a nano-antibacterial inorganic filler containing a quaternary ammonium salt with long chain alkyl and its effect on dental resin composites].
abstract: OBJECTIVE
  This study aimed to synthesize a novel nano-antibacterial inorganic filler that contains a quaternary ammonium salt with long chain alkyl and to report the antibacterial property of dental resin composites.
  
  
  METHODS
  A novel nano-antibacterial inorganic filler that contains a quaternary ammonium salt with long chain alkyl was synthesized based on previous research. The antibacterial property of the filler was measured. The surface of the novel nano-antibacterial inorganic filler was modified by a coupling agent to achieve a good interfacial bonding between the filler and the resin matrix. Infrared spectrum analysis was carried out. The modified novel nano-antibacterial inorganic fillers were then incorporated into the dental resin matrix. The dispersion of the fillers was observed and compared with those incorporated into Tetric N-Ceram, a commercial resin composite, under a scanning electron microscope. Streptococcus mutans was used in testing the antibacterial property of the dental resin composites.
  
  
  RESULTS
  A quaternary ammonium salt with a long chain alkyl was successfully grafted onto the surface of nano-silica particles. The novel nano-antibacterial inorganic filler that contains quaternary ammonium salt with a long chain alkyl showed stronger antibacterial efficacy than the antibacterial inorganic filler that contains quaternary ammonium salt with a short chain alkyl. The modified novel antibacterial inorganic fillers displayed a homogeneous dispersion in the resin composite bulk and combined closely with the resin matrix, similar to the Tetric N-Ceram. The resin composites that contain novel antibacterial inorganic fillers showed stronger antibacterial effect on Streptococcus mutans compared with the control group.
  
  
  CONCLUSIONS
  The novel nano-antibacterial inorganic filler that contains a quaternary ammonium salt with long chain alkyl showed a strong antibacterial property. It also exhibited good compatibility with the dental resin matrix after undergoing coupling treatment.
authors.forename: Wu
authors.initials: W
authors.lastname: Junling
authors.forename: Zhou
authors.initials: Z
authors.lastname: Kaiyun
authors.forename: Zhu
authors.initials: Z
authors.lastname: Ting
authors.forename: Zhou
authors.initials: Z
authors.lastname: Chuanjian
mesh_terms: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D003188:Composite Resins; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds; D013295:Streptococcus mutans
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C029012:Composite Dental Resin; D003188:Composite Resins; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds; C121818:Tetric ceram