title: The synthesis and antiproliferative activities of new arylidene-hydrazinyl-thiazole derivatives.
abstract: New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-4-methylthiazole on both MDA-MB-231 (IC50: 3.92 µg/mL) and HeLa (IC50: 11.4 µg/mL) cell lines, and for 2-[2-(4-methoxybenzylidene) hydrazinyl]-4-phenylthiazole on HeLa (IC50: 11.1 µg/mL) cell line is reported. Electrophoresis experiments showed no plasmid DNA (pTZ57R) cleavage in the presence of the investigated thiazoles.
authors.affiliation: Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. adriana.ignat@umfcluj.ro.
authors.forename: Adriana
authors.initials: A
authors.lastname: Grozav
authors.affiliation: Faculty of Chemistry and Chemical Engineering, University "Babes-Bolyai", M. Kogalniceanu 1, RO-400028 Cluj-Napoca. gluiza@chem.ubbcluj.ro.
authors.forename: Luiza Ioana
authors.initials: LI
authors.lastname: Găină
authors.affiliation: Research Center of Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Marinescu 23, RO-400337 Cluj-Napoca, Romania. valentinapilecki@gmail.com.
authors.forename: Valentina
authors.initials: V
authors.lastname: Pileczki
authors.affiliation: Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. ocrisan@umfcluj.ro.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Crisan
authors.affiliation: Faculty of Chemistry and Chemical Engineering, University "Babes-Bolyai", M. Kogalniceanu 1, RO-400028 Cluj-Napoca. lusi@chem.ubbcluj.ro.
authors.forename: Luminita
authors.initials: L
authors.lastname: Silaghi-Dumitrescu
authors.affiliation: Institut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland. bruno.therrien@unine.ch.
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
authors.affiliation: Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. vzaharia@umfcluj.ro.
authors.forename: Valentin
authors.initials: V
authors.lastname: Zaharia
authors.affiliation: Research Center of Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Marinescu 23, RO-400337 Cluj-Napoca, Romania. ioananeagoe29@gmail.com.
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan-Neagoe
mesh_terms: D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007364:Intercalating Agents / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006834:Hydrazines; D007364:Intercalating Agents; D013844:Thiazoles; D004247:DNA