title: What is the best biomarker for metabolic syndrome diagnosis?
abstract: OBJECTIVE
  There are three definitions belong to metabolic syndrome (MetS). These definitions have some differences that make some problem for MetS diagnosis criteria. So a new diagnosis marker can help to MetS diagnosis. The aim of this study was the assess of serum levels of leptin, total adiponectin, high molecular weight (HMW) adiponectin, and their ratio with MetS.
  
  
  METHODS
  We searched Science direct, Pubmed, and Google Scholar for related articles in English. Review studies excluded.
  
  
  RESULTS
  Of 1827 articles found, 16 articles met our inclusion criteria. leptin is higher in MetS group but adiponectin is lower (<4 μg/ml) and it shows the paradoxical effect of them in MetS. Higher L/A ratio is a better biomarker for MetS diagnosis criteria than leptin and adiponectin separately. HMW adiponectin (<2.5 μg/ml) can be the most reliable biomarker for MetS diagnosis criteria.
  
  
  CONCLUSIONS
  Our systematic review showed that HMW adiponectin and Leptin to adiponectin ratio should be the best biomarkers for MetS.
authors.affiliation: Nutrition Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: e_falahi@yahoo.com.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Falahi
authors.affiliation: Department of Nutrition, Faculty of Health & Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: amirhossein.khalkhalirad@yahoo.com.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Khalkhali Rad
authors.affiliation: Department of Nutrition, Faculty of Health & Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: sajjad.roosta@yahoo.com.
authors.forename: Sajjad
authors.initials: S
authors.lastname: Roosta
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis*; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Adiponectin; High molecular weight adiponectin (HMW); Leptin; Leptin to adiponectin ratio; Metabolic syndrome