title: A novel protocol for postpartum magnesium sulphate in severe pre-eclampsia: a randomized controlled pilot trial.
abstract: OBJECTIVE
  Magnesium sulphate is the preferred anticonvulsant used to prevent the development of fits in severe pre-eclampsia; we aim to compare between three different protocols of postpartum magnesium sulphate in the effectiveness of preventing the development of fits in severe pre-eclampsia.
  
  
  METHODS
  Double-blind randomized controlled pilot trial, done in Cairo university hospital, Cairo, Egypt during 2013-2014, on 240 women with severe pre-eclampsia. Magnesium sulphate intravenous infusion was given in the postpartum period to all the patients, women were randomly allocated to group I (Single loading dose only), group II (12 h abbreviated protocol) or group III (24 h standard protocol) (n = 80 in each group).
  
  
  RESULTS
  There were no significant difference between the three groups as regards the incidence of eclampsia, elevated liver enzymes and low platelets syndrome, maternal ICU admission and; however The incidence of flushing was significantly higher in group III than group II and I (24 [30%] versus 12 [15%] versus 4 [5%]; p < 0.001) respectively.
  
  
  CONCLUSIONS
  The pilot study demonstrates that the single-loading dose of postpartum magnesium sulphate is a promising alternative to the standard and the abbreviated protocol in preventing eclampsia; however, a large clinical trial is necessary to prove this.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt and.
authors.forename: Waleed
authors.initials: W
authors.lastname: El-Khayat
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt and.
authors.forename: Adel
authors.initials: A
authors.lastname: Atef
authors.affiliation: b Department of clinical and chemical pathology, Faculty of medicine , Cairo University , Cairo , Egypt.
authors.forename: Sahar
authors.initials: S
authors.lastname: Abdelatty
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt and.
authors.forename: Ali
authors.initials: A
authors.lastname: El-Semary
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage*; D002985:Clinical Protocols; D004461:Eclampsia / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D010865:Pilot Projects; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate
keywords: Abbreviated regimen; eclampsia; magnesium sulphate; pre-eclampsia