title: Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton.
abstract: Vibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system (T3SS) on each chromosome (T3SS1 and T3SS2). T3SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3SS genes present in V. parahaemolyticus, T3SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3SS2 effectors and their roles in virulence. This review focuses on the regulation of T3SS2 gene expression and T3SS2 effectors that specifically target the actin cytoskeleton.
authors.affiliation: Pathogenic Microbes Repository Unit, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kodama
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Hiyoshi
authors.forename: Ryu
authors.initials: R
authors.lastname: Okada
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Matsuda
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Gotoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Iida
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D058947:Bacterial Secretion Systems; D003967:Diarrhea / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D014735:Vibrio Infections / Q000382:microbiology; D014736:Vibrio parahaemolyticus / Q000378:metabolism / Q000502:physiology*
chemical_list: D058947:Bacterial Secretion Systems