title: [Experimental investigation of self-soluble cava-filter].
abstract: Pulmonary embolism accounts for sudden death of a third of patients. Endovascular catheter interventions including cava-filter implantation have the great promises for the prevention of pulmonary embolism and treatment of phlebothrombosis in inferior vena cava system. The aim of our research is creation of self-soluble cava-filter for prevention of pulmonary embolism and evaluation of opportunity of one-stage filter implantation. We conducted the series of experiments. We used 18 rabbits as experimental animals. The essence of experiment was to prove the possibility for application and to evaluate the extent of absorption of developed cava-filter in lumen of vena cava. It was revealed that copolymer rods implanted among gluteal muscles fibres and near ear vena completely dissolved after 40-50 days. Health of animals didn't change. The cava-filter dissolved partially. There were not toxic effects. The results suggest that there is need to continue research for developing of cava-filter of soluble copolymer.
authors.forename: A L
authors.initials: AL
authors.lastname: Charyshkin
authors.forename: L V
authors.initials: LV
authors.lastname: Glushenko
authors.forename: S N
authors.initials: SN
authors.lastname: Chvalun
authors.forename: N S
authors.initials: NS
authors.lastname: Sedush
mesh_terms: D020341:Absorbable Implants; D032761:Animal Experimentation; D000818:Animals; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods; D006801:Humans; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D011655:Pulmonary Embolism / Q000209:etiology / Q000517:prevention & control; D011817:Rabbits; D012995:Solubility; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000601:surgery; D020246:Venous Thrombosis / Q000150:complications*
chemical_list: D011091:Polyesters; C033616:poly(lactide)