title: Longitudinal assessment of clinically isolated syndrome with diffusion tensor imaging and volumetric MRI.
abstract: The potential of diffusion tensor imaging (DTI) indices and volumes of focal lesions on conventional magnetic resonance imaging to predict conversion to multiple sclerosis (MS) was analyzed in subjects with clinically isolated syndrome (CIS) over 4 years. Twenty patients with CIS and 10 healthy controls were included in the study. The data showed an association between the volumes of T1 and fluid-attenuated inversion recovery (FLAIR) lesions and conversion to MS (T1: P=.02; FLAIR: P=.02). The worsening of DTI indices (mean diffusivity and fractional anisotropy) was primarily seen in patients progressing to MS, but clear-cut association with conversion could not be detected.
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere, Finland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kolasa
authors.affiliation: Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland; Department of Electronics and Communications Engineering Tampere University of Technology, Tampere, Finland.
authors.forename: Ullamari
authors.initials: U
authors.lastname: Hakulinen
authors.affiliation: Science Center, Pirkanmaa Hospital District and School of Health Sciences, University of Tampere, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Helminen
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere, Finland.
authors.forename: Sanna
authors.initials: S
authors.lastname: Hagman
authors.affiliation: Department of Neurology, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Minna
authors.initials: M
authors.lastname: Raunio
authors.affiliation: Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland.
authors.forename: Maija
authors.initials: M
authors.lastname: Rossi
authors.affiliation: Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Brander
authors.affiliation: Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland.
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere, Finland; Department of Neurology, Tampere University Hospital, Tampere, Finland. Electronic address: irina.elovaara@uta.fi.
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D066127:White Matter / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult
keywords: Clinically isolated syndrome; Diffusion tensor; Normal-appearing gray matter; Normal-appearing white matter; Volume measurements