title: Low prevalence of Clostridium septicum fecal carriage in an adult population.
abstract: Clostridium septicum is an uncommon cause of severe infection. Real-time PCR against the C. septicum-specific alpha-toxin gene (csa) was used to estimate the prevalence of this microbe in human stool from 161 asymptomatic community-dwelling adults and 192 hospitalized patients with diarrhea. All samples were negative, suggesting a low prevalence.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, USA.
authors.forename: Fatos A
authors.initials: FA
authors.lastname: Kopliku
authors.affiliation: Department of Microbiology and Immunology, University of Michigan, USA.
authors.forename: Alyxandria M
authors.initials: AM
authors.lastname: Schubert
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, USA.
authors.forename: Jill
authors.initials: J
authors.lastname: Mogle
authors.affiliation: Department of Microbiology and Immunology, University of Michigan, USA.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Schloss
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, USA; Department of Microbiology and Immunology, University of Michigan, USA.
authors.forename: Vincent B
authors.initials: VB
authors.lastname: Young
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Vanderbilt University, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, USA. Electronic address: d.aronoff@vanderbilt.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Aronoff
mesh_terms: D000328:Adult; D002353:Carrier State; D003015:Clostridium Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D052557:Clostridium septicum / Q000145:classification / Q000235:genetics*; D004269:DNA, Bacterial; D005243:Feces / Q000382:microbiology*; D005738:Gas Gangrene / Q000453:epidemiology / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D016133:Polymerase Chain Reaction; D015995:Prevalence
chemical_list: D004269:DNA, Bacterial
keywords: Clostridial infections; Malignancy; Microbiome; Myonecrosis; Sepsis