title: Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation.
abstract: Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Malathi
authors.initials: M
authors.lastname: Mathiyazhakan
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Yuanxiang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Caigang
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Division of Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Claus-Dieter
authors.initials: CD
authors.lastname: Ohl
authors.affiliation: Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Kam Chiu
authors.initials: KC
authors.lastname: Tam
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore. Electronic address: cjxu@ntu.edu.sg.
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
mesh_terms: D003692:Delayed-Action Preparations; D065546:Drug Liberation; D005452:Fluoresceins / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D007834:Lasers; D008081:Liposomes / Q000737:chemistry* / Q000528:radiation effects*; D053768:Metal Nanoparticles / Q000737:chemistry*; D045423:Microbubbles; D010316:Particle Size; D055668:Photochemical Processes; D013499:Surface Properties
chemical_list: D003692:Delayed-Action Preparations; D005452:Fluoresceins; D008081:Liposomes; D006046:Gold; C007740:fluorexon
keywords: Controlled release; Drug delivery; Exogenous stimuli-responsive nanoparticles; Gold nanoparticles; Microbubble cavitation; Thermal-responsive liposome