title: Regulatory SNPs and transcriptional factor binding sites in ADRBK1, AKT3, ATF3, DIO2, TBXA2R and VEGFA.
abstract: Abstract Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes. Changes in the TFBS where TFs attach to regulate these genes may result in human sickness and disease. The highlights of this previous work were reviewed for these genes.
authors.affiliation: a Department of Pediatrics , University of Washington , Seattle , WA USA.
authors.forename: Norman E
authors.initials: NE
authors.lastname: Buroker
mesh_terms: D051700:Activating Transcription Factor 3 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D055106:Genome-Wide Association Study; D006801:Humans; D007453:Iodide Peroxidase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000235:genetics; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020506:Untranslated Regions; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000097564:Iodothyronine Deiodinase Type II
chemical_list: D051700:Activating Transcription Factor 3; D054769:G-Protein-Coupled Receptor Kinase 2; D007453:Iodide Peroxidase; D051057:Proto-Oncogene Proteins c-akt; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D014157:Transcription Factors; D020506:Untranslated Regions; D042461:Vascular Endothelial Growth Factor A; D000097564:Iodothyronine Deiodinase Type II; C490449:ATF3 protein, human; C467484:VEGFA protein, human; C491754:AKT3 protein, human; C496567:GRK2 protein, human
keywords: ADRBK1; AKT3; ATF3; DIO2; TBXA2R and VEGFA genes; rSNPs; transcriptional factor binding site; transcriptional factors