title: A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking.
abstract: This review presents a novel view and working hypothesis about the hierarchy within the adult bone marrow stem cell compartment and the still-intriguing question of whether adult bone marrow contains primitive stem cells from early embryonic development, such as cells derived from the epiblast, migrating primordial germ cells or yolk sac-derived hemangioblasts. It also presents a novel view of the mechanisms that govern stem cell mobilization and homing, with special emphasis on the role of the complement cascade as a trigger for egress of hematopoietic stem cells from bone marrow into blood as well as the emerging role of novel homing factors and priming mechanisms that support stromal-derived factor 1-mediated homing of hematopoietic stem/progenitor cells after transplantation.
authors.affiliation: Stem Cell Biology Program, Stella and Henry Hoenig Endowed Chair, Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Ratajczak
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism; D001854:Bone Marrow Cells / Q000145:classification / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D019070:Cell Lineage / Q000235:genetics / Q000276:immunology; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000235:genetics / Q000276:immunology; D003165:Complement System Proteins / Q000235:genetics; D015870:Gene Expression; D005854:Germ Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D006801:Humans
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D003165:Complement System Proteins