title: Hippo pathway in mammary gland development and breast cancer.
abstract: Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor growth, metastasis, and drug resistance. It is expected that the Hippo pathway will provide novel therapeutic targets for breast cancer. This review will discuss and summarize the roles of several core components of the Hippo pathway in mammary gland development and breast cancer.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, China University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Peiguo
authors.initials: P
authors.lastname: Shi
authors.affiliation: Department of laboratory medicine & Central Laboratory, South Medical University Affiliated Fengxian Hospital, Shanghai 201499, China chenc@mail.kiz.ac.cn fengjing8801530@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, China chenc@mail.kiz.ac.cn fengjing8801530@163.com.
authors.forename: Ceshi
authors.initials: C
authors.lastname: Chen
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D063646:Carcinogenesis; D049109:Cell Proliferation / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D000090683:Hippo Signaling Pathway; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D042361:Mammary Glands, Human / Q000254:growth & development* / Q000473:pathology; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017346:Protein Serine-Threonine Kinases
keywords: Hippo pathway; TAZ; YAP; breast cancer; mammary gland development