title: Two new terpenoids from the stems of Manihot esculenta.
abstract: A new eremophilane sesquiterpene, sporogen AO-2 (1), and a new beyerane diterpene, thecacorin C (2), together with two known compounds, longifoamide-B (3) and methylcholestane-3β,5α,6β-triol (4), were isolated from the stems of Manihot esculenta. The structures of the two new compounds were determined by spectroscopic techniques (UV, IR, MS, 1D, and 2D NMR). Antimicrobial assay showed that compound 3 possessed modest inhibitory effects on Saphylococcus aureus and methicillin-resistant S.aureus, diameters of inhibition zones of which were 7.5 and 8.0 mm, respectively. Compound 4 possessed modest inhibitory effect on S. aureus, the diameter of inhibition zone of which was 6.8 mm.
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Li
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Kai-Mian
authors.initials: KM
authors.lastname: Li
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002365:Manihot / Q000737:chemistry*; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D012717:Sesquiterpenes; C000598455:sporogen AO-2; C000598456:thecacorin C
keywords: Euphorbiaceae; Manihot esculenta; Saphylococcus aureus; antimicrobial; sporogen AO-2; thecacorin C