title: Multiple types of logic gates based on a single G-quadruplex DNA strand.
abstract: In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K(+), thrombin, Hg(2+), and Pb(2+)) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.
authors.affiliation: 1] Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China) [2] Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry &Molecular Sciences, Wuhan University, Wuhan, 430072 (China).
authors.forename: Yahui
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China).
authors.forename: Lu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China).
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry &Molecular Sciences, Wuhan University, Wuhan, 430072 (China).
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry &Molecular Sciences, Wuhan University, Wuhan, 430072 (China).
authors.forename: Jiming
authors.initials: J
authors.lastname: Hu
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China).
authors.forename: Renjun
authors.initials: R
authors.lastname: Pei
mesh_terms: D039301:Computers, Molecular; D004277:DNA, Single-Stranded / Q000737:chemistry*; D054856:G-Quadruplexes; D007854:Lead / Q000737:chemistry; D008628:Mercury / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D013917:Thrombin / Q000737:chemistry
chemical_list: D004277:DNA, Single-Stranded; D007854:Lead; D013917:Thrombin; D008628:Mercury; D011188:Potassium