title: Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases.
abstract: BACKGROUND
  There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders, especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.
  
  
  METHODS
  We carried out a PubMed search of English-language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.
  
  
  RESULTS
  The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however, reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.
  
  
  CONCLUSIONS
  The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases is observed, but the exact role of these enzymes demands further studies.
authors.affiliation: Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a, Lublin 20-093, Poland. jacek.kurzepa@umlub.pl.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kurzepa
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mądro
authors.forename: Grażyna
authors.initials: G
authors.lastname: Czechowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Kurzepa
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Celiński
authors.forename: Weronika
authors.initials: W
authors.lastname: Kazmierak
authors.forename: Maria
authors.initials: M
authors.lastname: Slomka
mesh_terms: D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D061965:Matrix Metalloproteinase Inhibitors / Q000378:metabolism*; D050500:Pancreatitis, Chronic / Q000378:metabolism; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9