title: Synthetic fluorescent probes capable of selective recognition of 3'-overhanging nucleotides for siRNA delivery imaging.
abstract: Peptide nucleic acid (PNA)-thiazole orange (TO) conjugates are developed as fluorescent probes capable of selective recognition of 3'-overhanging nucleotides of siRNAs for an accurate analysis of the siRNA delivery process.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. satoyuu@m.tohoku.ac.jp teramae@m.tohoku.ac.jp.
authors.forename: Takaya
authors.initials: T
authors.lastname: Sato
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.forename: Kenta
authors.initials: K
authors.lastname: Iwai
authors.forename: Shusuke
authors.initials: S
authors.lastname: Kuge
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Norio
authors.initials: N
authors.lastname: Teramae
mesh_terms: D052160:Benzothiazoles / Q000008:administration & dosage* / Q000737:chemistry; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000008:administration & dosage* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D009711:Nucleotides / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000008:administration & dosage* / Q000737:chemistry; D011804:Quinolines / Q000008:administration & dosage* / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D009711:Nucleotides; D020135:Peptide Nucleic Acids; D011804:Quinolines; D034741:RNA, Small Interfering; C051000:thiazole orange