title: Potential New Pharmacological Agents Derived From Medicinal Plants for the Treatment of Pancreatic Cancer.
abstract: In the present article, we reviewed plants and phytochemical compounds demonstrating beneficial effects in pancreatic cancer to find new sources of pharmaceutical agents. For this purpose, Scopus, PubMed, Web of Science, and Google scholar were searched for plants or herbal components with beneficial effects in the treatment of pancreatic cancer. Data were collected up to January 2013. The search terms were "plant," "herb," "herbal therapy," or "phytotherapy" and "pancreatic cancer" or "pancreas." All of the human in vivo and in vitro studies were included. According to studies, among diverse plants and phytochemicals, 12 compounds including apigenin, genistein, quercetin, resveratrol, epigallocatechin gallate, benzyl isothiocyanate, sulforaphane, curcumin, thymoquinone, dihydroartemisinin, cucurbitacin B, and perillyl alcohol have beneficial action against pancreatic cancer cells through 4 or more mechanisms. Applying their plausible synergistic effects can be an imperative approach for finding new efficient pharmacological agents in the treatment of pancreatic cancer.
authors.affiliation: From the *Faculty of Pharmacy, Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, and †Faculty of Traditional Medicine, Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Haniye
authors.initials: H
authors.lastname: Azimi
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Khakshur
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Roja
authors.initials: R
authors.lastname: Rahimi
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D011838:Radiation-Sensitizing Agents