title: p23 and Aha1.
abstract: Hsp90 is a conserved molecular chaperone and is responsible for the folding and activation of several hundred client proteins, involved in various cellular processes. The large number and the diversity of these client proteins demand a high adaptiveness of Hsp90 towards the need of the individual client. This adaptiveness is amongst others mediated by more than 20 so-called cochaperones that differ in their actions towards Hsp90. Some of these cochaperones are able to modulate the ATPase activity of Hsp90 and/or its client protein binding, folding and activation. p23 and Aha1 are two prominent examples with opposing effects on the ATPase activity of Hsp90. p23 is able to inhibit the ATP turnover while Aha1 is the strongest known activator of the ATPase activity of Hsp90. Even though both cochaperones are conserved from yeast to man and have been studied for years, some Hsp90-related as well as Hsp90-independent functions are still enigmatic and under current investigation. In this chapter, we first introduce the ATPase cycle of Hsp90 and then focus on the two cochaperones integrating them in the Hsp90 cycle.
authors.affiliation: Department Chemie, Technische Universität München, Munich, Germany, alexandra.rehn@tum.de.
authors.forename: Alexandra Beatrice
authors.initials: AB
authors.lastname: Rehn
authors.forename: Johannes
authors.initials: J
authors.lastname: Buchner
mesh_terms: D000818:Animals; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism*; D000071876:Prostaglandin-E Synthases; D011487:Protein Conformation; D017510:Protein Folding; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: C515652:AHSA1 protein, human; D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases