title: Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide.
abstract: In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.
authors.affiliation: Key Laboratory of Eco-Textiles, Ministry of Education (Jiangnan University), Wuxi 214122, China; College of Textile & Clothing, Jiangnan University, Wuxi 214122, China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Eco-Textiles, Ministry of Education (Jiangnan University), Wuxi 214122, China; College of Textile & Clothing, Jiangnan University, Wuxi 214122, China.
authors.forename: Tianxun
authors.initials: T
authors.lastname: Gu
authors.affiliation: Key Laboratory of Eco-Textiles, Ministry of Education (Jiangnan University), Wuxi 214122, China; College of Textile & Clothing, Jiangnan University, Wuxi 214122, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Fu
authors.affiliation: Key Laboratory of Eco-Textiles, Ministry of Education (Jiangnan University), Wuxi 214122, China; College of Textile & Clothing, Jiangnan University, Wuxi 214122, China; Technical University of Denmark, DTU Food, Søltofts plads, B227, 2800 Kgs. Lyngby, Denmark. Electronic address: leecaiwei@163.com.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Technical University of Denmark, DTU Food, Søltofts plads, B227, 2800 Kgs. Lyngby, Denmark.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Chronakis
authors.affiliation: Key Laboratory of Eco-Textiles, Ministry of Education (Jiangnan University), Wuxi 214122, China; College of Textile & Clothing, Jiangnan University, Wuxi 214122, China.
authors.forename: Mingqiao
authors.initials: M
authors.lastname: Ge
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004987:Ethers / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D054118:Nanospheres / Q000737:chemistry* / Q000633:toxicity; D009569:Nitric Oxide / Q000032:analysis*; D010316:Particle Size; D045663:Quantum Dots / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D019187:Cadmium Compounds; D004987:Ethers; D037741:Fullerenes; D018036:Selenium Compounds; D009569:Nitric Oxide; C058667:cadmium selenide
keywords: Biomaterials; Composite materials; Fullerenes; Surface properties