title: Two minor chalcone acetylglycosides from the roots extract of Glycyrrhiza uralensis.
abstract: An extensive phytochemical investigation on the roots of Glycyrrhiza uralensis led to the isolation of two new minor chalcone acetylglycosides, i.e., 6″-O-acetylisoliquiritin (1) and 6″-O-acetylneoisoliquiritin (2), including 16 kinds of known constituents (3-18) of flavonoids, chalcones and triterpene saponins. The chemical structures of 1 and 2 were established by spectroscopic analyses of them, particularly by the aid of two-dimensional NMR experiments, COSY, DEPT, HSQC and HMBC. Some isolated components except 1 and 2 exhibited significant inhibitory effects on the proliferation of cultured tumor cell lines, such as A549, SK-OV-3, A-498, and HCD15, in vitro.
authors.affiliation: Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jinhee
authors.initials: J
authors.lastname: Kim
authors.forename: Kwangho
authors.initials: K
authors.lastname: Lee
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D047188:Chalcones; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins