title: MicroRNAs: association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches.
abstract: Radiotherapy plays an essential primary role in cancer patients. Regardless of its significant advances in treatment options, tumor recurrence and radio-resistance in cancer cells still occur in a high percentage of patients. Furthermore, the over expression of miRNAs accompanies the development of radio-resistant cancer cells. Consequently, miRNAs might serve as therapeutic targets for the treatment of radio-resistance in cancer cells. The findings of the current research also signify that the use of a natural anti-miRNA substance could inhibit specific miRNAs, and, concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy. Therefore, in this review, we have reported the association of miRNAs with radio-resistance and the potential uses of natural remedies as green gene therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation on healthy cells during radiotherapy.
authors.forename: Subramanion L
authors.initials: SL
authors.lastname: Jothy
authors.forename: Yeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Soundararajan
authors.initials: S
authors.lastname: Vijayarathna
authors.forename: Jagat R
authors.initials: JR
authors.lastname: Kanwar
authors.affiliation: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia. srisasidharan@yahoo.com.
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Sasidharan
mesh_terms: D045744:Cell Line, Tumor; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D064209:Phytochemicals / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods
chemical_list: D035683:MicroRNAs; D064209:Phytochemicals; D011837:Radiation-Protective Agents