title: The Effect of Systemic Tamsulosin Hydrochloride on Choroidal Thickness Measured by Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography.
abstract: BACKGROUND
  To evaluate the effects of selective α1A-adrenoceptor antagonist tamsulosin hydrochloride on choroidal thickness using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).
  
  
  METHODS
  This is a prospective observational study including 29 eyes of 29 patients with newly diagnosed benign prostatic hyperplasia. Choroidal thickness and retrobulbar ocular blood flow measurements were performed at baseline and after 3 months of treatment. Results were analyzed by the masked observer.
  
  
  RESULTS
  The mean subfoveal choroidal thickness (275.8-291.9 µm) and thicknesses 750 µm nasal (257.9-270.4 µm) and 750 µm temporal (262.4-277.0 µm) to the fovea were significantly increased after 3 months of treatment (p < 0.001). No statistically significant change was found in retrobulbar ocular blood flow.
  
  
  CONCLUSIONS
  Tamsulosin causes a significant increase in EDI-OCT-based choroidal thickness measurements. This increase might be associated with choroidal vasodilation in consequence of blockade of sympathetic α1A-adrenoceptors, which is critical for the maintenance of vascular tone and resistance in the choroidal vascular architecture. This should be kept in mind when choroidal disease and its response to treatment are followed by EDI-OCT imaging.
authors.affiliation: a Department of Urology .
authors.forename: Erhan
authors.initials: E
authors.lastname: Sari
authors.affiliation: b Department of Ophthalmology .
authors.forename: Esin Sogutlu
authors.initials: ES
authors.lastname: Sari
authors.affiliation: b Department of Ophthalmology .
authors.forename: Alper
authors.initials: A
authors.lastname: Yazici
authors.affiliation: a Department of Urology .
authors.forename: Akif
authors.initials: A
authors.lastname: Koç
authors.affiliation: c Department of Radiology, Faculty of Medicine , Balikesir University , Balıkesir , Turkey .
authors.forename: Erdogan
authors.initials: E
authors.lastname: Bulbul
authors.affiliation: d Department of Ophthalmology, Faculty of Medicine , Bezmialem Vakif University , İstanbul , Turkey and.
authors.forename: Arif
authors.initials: A
authors.lastname: Koytak
authors.affiliation: b Department of Ophthalmology .
authors.forename: Sitki Samet
authors.initials: SS
authors.lastname: Ermis
authors.affiliation: e Department of Ophthalmology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Muhammet Kazim
authors.initials: MK
authors.lastname: Erol
mesh_terms: D000284:Administration, Oral; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000368:Aged; D001783:Blood Flow Velocity; D002829:Choroid / Q000098:blood supply / Q000473:pathology*; D019842:Ciliary Arteries / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000502:physiology; D009929:Organ Size; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000503:physiopathology; D012039:Regional Blood Flow; D012161:Retinal Artery / Q000502:physiology; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D041623:Tomography, Optical Coherence; D018615:Ultrasonography, Doppler, Color
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin
keywords: Choroidal thickness; enhanced depth imaging optical coherence tomography; tamsulosin