title: An overview of naturally occurring histone deacetylase inhibitors.
abstract: Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.
authors.forename: Bumki
authors.initials: B
authors.lastname: Kim
authors.affiliation: Duke University, Department of Chemistry, 124 Science Drive, Box 90346, Durham, NC 27708, USA. jiyong.hong@duke.edu.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Hong
mesh_terms: D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry*; D019175:DNA Methylation; D055808:Drug Discovery; D044127:Epigenesis, Genetic; D006570:Heterochromatin / Q000737:chemistry / Q000378:metabolism; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006655:Histone Deacetylases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011499:Protein Processing, Post-Translational
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D006570:Heterochromatin; D056572:Histone Deacetylase Inhibitors; D007527:Isoenzymes; D018696:Neuroprotective Agents; D006655:Histone Deacetylases