title: Specific organ metastases and survival in metastatic non-small-cell lung cancer.
abstract: The present retrospective study was performed to evaluate the clinicopathological characteristics associated with distant metastasis from non-small-cell lung cancer (NSCLC). The records of NSCLC patients with metastasis at the time of diagnosis between 1999 and 2012 were reviewed. Of the consecutive 1,542 NSCLC patients diagnosed during the study period, 729 (47.3%) patients presented with distant metastasis. Among those 729 metastatic NSCLC patients, 250 (34.3%), 234 (32.1%), 207 (28.4%), 122 (16.7%), 98 (13.4%) and 69 (9.5%) had bone, lung, brain, adrenal gland, liver and extrathoracic lymph node metastasis, respectively. In a multivariate analysis using the Cox proportional hazards model, liver and adrenal gland metastases were unfavorable prognostic factors. However, brain and bone metastases were not statistically significant prognostic factors. Using a logistic regression analysis, metastasis to the adrenal glands and the presence of pleural and/or pericardial fluid effusion were correlated with a poor performance status. Therefore, when planning the treatment of NSCLC patients, particularly those with liver and adrenal gland metastases, we should take into consideration information regarding these unfavorable organ metastases.
authors.affiliation: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba; Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tamura
authors.affiliation: Division of Respiratory Medicine, Tsukuba Medical Center Hospital; Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kurishima
authors.affiliation: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba; Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakazawa
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Kagohashi
authors.affiliation: Division of Respiratory Medicine, Tsukuba Medical Center Hospital; Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Hiroichi
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.affiliation: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba; Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
keywords: metastasis; non-small-cell lung cancer; survival