title: Diagnostic value of interleukin-8 in colorectal cancer: a case-control study and meta-analysis.
abstract: OBJECTIVE
  To assess the diagnostic value of serum interleukin-8 (IL-8) in the detection of colorectal cancer (CRC).
  
  
  METHODS
  An original study was conducted to explore the potential value of IL-8 in CRC diagnosis. Receiver operating characteristic (ROC) analysis was performed and the area under the curve (AUC) value was calculated. PUBMED and EMBASE were searched (to October, 2013), supplemented with manual screening for relevant publications. Meta-analysis methods were applied to pool sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratios and to construct a summary receiver-operating characteristic (sROC) curve. Heterogeneity across studies was checked by the I(2) test and Deek's funnel plot method was applied to test publication bias.
  
  
  RESULTS
  In our original study, serum IL-8 yielded an AUC of 0.742 [95%CI: 0.635-0.849]. The sensitivity and specificity were 85.42% and 54.05%, respectively, at a cut-off value of 5.39. In this meta-analysis, we included five studies with 668 CRC patients and 374 controls and one study in our own center with 48 CRC patients and 37 controls. The pooled sensitivity and specificity of IL-8 were 0.69 (95%CI: 0.42-0.87) and 0.85 (95%CI: 0.68-0.94) for CRC detection. Besides, the area under the sROC curve was 0.86 (95%CI: 0.82-0.88). Subgroup analysis suggested that there was no heterogeneity in the Asian subgroup but some in the European subgroup. In addition, no publication bias was found according to the Deek's funnel plot asymmetry test.
  
  
  CONCLUSIONS
  Serum IL-8 is a promising biomarker for CRC detection and may become a clinically useful tool to identify high-risk patients.
authors.affiliation: Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Jin
authors.affiliation: Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Xu
authors.affiliation: Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Xu
authors.affiliation: Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: Gu
authors.affiliation: Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
authors.forename: Pei-Wei
authors.initials: PW
authors.lastname: Li
mesh_terms: D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000208:ethnology; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C508606:CXCL8 protein, human; D016209:Interleukin-8
keywords: Case-control study; Colorectal cancer; Diagnostic value; Interleukin-8; Meta-analysis