title: Synchronous diffuse large B-cell lymphoma and squamous cell lung carcinoma.
abstract: A 68-year-old woman was referred for a nodule in the right lung and hilar and mediastinal lymphadenopathy. Physical examination revealed left cervical lymphadenopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images revealed radiotracer uptake in the pulmonary nodule and multiple lymph nodes of the truncus. Biopsies confirmed the diagnosis of synchronous diffuse large B-cell lymphoma and squamous cell lung carcinoma. Because the etiology of hilar and mediastinal lymphadenopathy was unknown, the staging of lung cancer could not be determined. We performed therapy for malignant lymphoma earlier than lung cancer. After therapy, FDG-PET showed that uptake in the lymph nodes due to lymphoma had disappeared, whereas uptake in the pulmonary nodule and right hilar lymph node remained or had increased. Based on these findings, the staging of lung cancer was determined and radical surgery was performed successfully. This rare case of synchronous malignancy illustrates the limitation of initial single testing of FDG-PET.
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital Shizuoka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital Shizuoka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shirai
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital Shizuoka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Asada
authors.affiliation: Department of Hematology, Shizuoka General Hospital Shizuoka, Japan.
authors.forename: Yuu
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Department of Thoracic Surgery, Shizuoka General Hospital Shizuoka, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Hirose
authors.affiliation: Second Department of Internal Medicine, Hamamatsu University School of Medicine Hamamatsu, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
keywords: 18F-fluorodeoxyglucose positron emission tomography; diffuse large B-cell lymphoma; squamous cell lung carcinoma; staging; synchronous