title: [Causes of lymphocytic meningitis in people with HIV admitted to the Infectious Disease department of Conakry].
abstract: OBJECTIVE
  The advent of HIV infection has significantly changed the distribution of the causes of lymphocytic meningitis. The objective of this study was to identify these causes among persons with HIV hospitalized in the infectious disease department of the CHU of Conakry.
  
  
  METHODS
  This retrospective study examined hospital records of patients with HIV infection admitted for lymphocytic meningitis over a 10-year period.
  
  
  RESULTS
  Of the 8649 hospitalizations in the department during the study period, 3167 patients had HIV infection, and 85 of the latter were diagnosed with lymphocytic meningitis. Slightly more than half were male (sex ratio M/F = 1.1). Their mean age was 32 years. Of these 85 patients, 73 were positive for HIV-1 only and 12 for HIV1+2. A CD4 count was performed only in 13/85 patients and averaged 140 cells/mm3. The main causes associated with lymphocytic meningitis were cryptococcosis (58%), toxoplasmosis (5%), and tuberculosis (2%). Streptococcus pneumoniae, Neisseria meningitidis, and Hæmophilus influenzae were also identified in 16% of cases. In 18% of cases no microbe was identified. The overall lethality rate was 68%; it reached 100% for tuberculous meningitis and for the cases without any identified cause and was 75%-76% for the patients with toxoplasmosis and cryptococcosis. The survival rate was 100% for all bacterial causes.
  
  
  CONCLUSIONS
  A cause for lymphocytic meningitis was identified in more than 81% of the patients in our series, and the most common microbe was Cryptococcus neoformans. A better microbiological technical platform and improved accessibility to treatment would enable us to provide more relevant results and treatment.
authors.affiliation: Service des maladies infectieuses et tropicales de l'hôpital national Donka, CHU de Conakry, Guinée, Université Gamal-Abdel-Nasser de Conakry, commune de Dixinn, 224 Conakry, Guinée.
authors.forename: F A
authors.initials: FA
authors.lastname: Traoré
authors.affiliation: Centre national de transfusion sanguine (CNTS), Bamako, Mali.
authors.forename: Y
authors.initials: Y
authors.lastname: Cissoko
authors.affiliation: Université Gamal-Abdel-Nasser de Conakry, commune de Dixinn, 224 Conakry, Guinée, Service de dermatologie-MST de Conakry, Guinée.
authors.forename: T M
authors.initials: TM
authors.lastname: Tounkara
authors.affiliation: Service des maladies infectieuses et tropicales de l'hôpital national Donka, CHU de Conakry, Guinée, Université Gamal-Abdel-Nasser de Conakry, commune de Dixinn, 224 Conakry, Guinée.
authors.forename: F B
authors.initials: FB
authors.lastname: Sako
authors.affiliation: Service des maladies infectieuses et tropicales de l'hôpital national Donka, CHU de Conakry, Guinée.
authors.forename: A D
authors.initials: AD
authors.lastname: Mouelle
authors.affiliation: Service des maladies infectieuses et tropicales de l'hôpital national Donka, CHU de Conakry, Guinée.
authors.forename: D O
authors.initials: DO
authors.lastname: Kpami
authors.affiliation: Médecin sans frontières, France.
authors.forename: M
authors.initials: M
authors.lastname: Traoré
authors.affiliation: Service des maladies infectieuses et tropicales de l'hôpital national Donka, CHU de Conakry, Guinée.
authors.forename: M
authors.initials: M
authors.lastname: Doumbouya
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D016701:Guinea / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000453:epidemiology / Q000382:microbiology*; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D055815:Young Adult
keywords: Guinea; HIV; cryptococcosis; lymphocytic meningitis