title: An improved efficient synthesis of the antibacterial agent torezolid.
abstract: An improved and efficient method for the preparation of torezolid based on Suzuki cross-coupling reaction as the key step was developed on a gram scale in five steps. The total yield was 44% and the optical purity of torezolid by the improved method was above 99%.
authors.affiliation: State Key Laboratory of Bioactive Substances and Function of Natural Medicine and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Bao-Kun
authors.initials: BK
authors.lastname: Yuan
authors.forename: Wu
authors.initials: W
authors.lastname: Tang
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Zhao
authors.forename: Zi-Yun
authors.initials: ZY
authors.lastname: Lin
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Huang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D023303:Oxazolidinones; D013777:Tetrazoles; D010165:Palladium; C546016:tedizolid