title: The rules of aging: are they universal? Is the yeast model relevant for gerontology?
abstract: The success of experimental biology was possible due to the use of model organisms. It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms. The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging. Furthermore, the use of unicellular organisms like yeast Saccharomyces cerevisiae to explain the aging processes of multicellular organisms runs the risk of oversimplification. Aging is a very complex process and therefore in this paper we present arguments suggesting that some of these fundamental assumptions require a deep rethinking and verification.
authors.affiliation: Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bilinski
authors.affiliation: Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Zadrag-Tecza
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D005853:Geriatrics; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000378:metabolism