title: Mannich bases: an important pharmacophore in present scenario.
abstract: Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.
authors.affiliation: M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
authors.forename: Suman
authors.identifier: 0000-0002-5102-7372
authors.initials: S
authors.lastname: Bala
authors.affiliation: M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Sharma
authors.affiliation: M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
authors.forename: Anu
authors.initials: A
authors.lastname: Kajal
authors.affiliation: M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
authors.forename: Sunil
authors.identifier: 0000-0001-5531-6019
authors.initials: S
authors.lastname: Kamboj
authors.affiliation: M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Saini