title: Copper-catalyzed three-component synthesis of benzothiazolethiones from o-iodoanilines, isocyanide, and potassium sulfide.
abstract: An efficient copper catalyzed strategy for the synthesis of a variety of benzothiazolethione derivatives has been developed. In the presence of CuCl, the three-component reaction of o-iodoanilines and K2S with p-toluenesulfonylmethyl isocyanide proceeded smoothly to obtain the corresponding benzothiazolethiones in good to excellent isolated yields. Notably, isocyanide functioned as a carbon source and K2S functioned as a sulfur source in this reaction.
authors.affiliation: National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University , Changsha, Hunan 410081, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Dang
authors.forename: Weilan
authors.initials: W
authors.lastname: Zeng
authors.forename: Yun
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D052160:Benzothiazoles; D003486:Cyanides; D013440:Sulfides; D053778:Thiazolidines; C033089:thiazoline-2-thione; C075715:3-iodoaniline; D003300:Copper; C028419:cuprous chloride; D011188:Potassium