title: Partial volume correction in quantitative amyloid imaging.
abstract: Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. As positron emission tomography (PET) scanners have limited spatial resolution, measured signals are distorted by partial volume effects. Various techniques have been proposed for correcting partial volume effects, but there is no consensus as to whether these techniques are necessary in amyloid imaging, and, if so, how they should be implemented. We evaluated a two-component partial volume correction technique and a regional spread function technique using both simulated and human Pittsburgh compound B (PiB) PET imaging data. Both correction techniques compensated for partial volume effects and yielded improved detection of subtle changes in PiB retention. However, the regional spread function technique was more accurate in application to simulated data. Because PiB retention estimates depend on the correction technique, standardization is necessary to compare results across groups. Partial volume correction has sometimes been avoided because it increases the sensitivity to inaccuracy in image registration and segmentation. However, our results indicate that appropriate PVC may enhance our ability to detect changes in amyloid deposition.
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: suy@mir.wustl.edu.
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Tyler M
authors.initials: TM
authors.lastname: Blazey
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Raichle
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Marcus
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Beau M
authors.initials: BM
authors.lastname: Ances
authors.affiliation: Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Bateman
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Cairns
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Aldea
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Cash
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Jon J
authors.initials: JJ
authors.lastname: Christensen
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Karl
authors.initials: K
authors.lastname: Friedrichsen
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Russ C
authors.initials: RC
authors.lastname: Hornbeck
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Farrar
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Owen
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: William
authors.initials: W
authors.lastname: Klunk
authors.affiliation: Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: Julie C
authors.initials: JC
authors.lastname: Price
authors.affiliation: Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA 90032, USA; Department of Neurology, University of Southern California, Los Angeles, CA 90032, USA; Department of Psychiatry, University of Southern California, Los Angeles, CA 90032, USA; Department of Engineering, University of Southern California, Los Angeles, CA 90032, USA; Department of Radiology, University of Southern California, Los Angeles, CA 90032, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA 90032, USA; Department of Ophthalmology, University of Southern California, Los Angeles, CA 90032, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Bernadino
authors.initials: B
authors.lastname: Ghetti
authors.affiliation: Center for Neuroimaging, Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.affiliation: Neuroscience Research Australia, Sydney, NSW 2031, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Schofield
authors.affiliation: Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Virginia
authors.initials: V
authors.lastname: Buckles
authors.affiliation: Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Tammie L S
authors.initials: TLS
authors.lastname: Benzinger
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000682:Amyloid / Q000378:metabolism*; D017772:Amyloid Neuropathies / Q000000981:diagnostic imaging*; D000814:Aniline Compounds; D052160:Benzothiazoles; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D003198:Computer Simulation; D003430:Cross-Sectional Studies; D006801:Humans; D007206:Individuality; D008137:Longitudinal Studies; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: Amyloid imaging; PET; Partial volume correction; PiB