title: Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.
abstract: Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.
authors.affiliation: Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Baugé
authors.affiliation: Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Girard
authors.affiliation: Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Lhuissier
authors.affiliation: Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France ; Service d'Anatomie Pathologique, CHU, Caen, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Bazille
authors.affiliation: Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Boumediene
keywords: TGFbeta; aging; chondrocytes; osteoarthritis