title: Developmental mechanisms channeling cortical evolution.
abstract: Increase in the area and neuron number of the cerebral cortex over evolutionary time systematically changes its computational properties. One of the fundamental developmental mechanisms generating the cortex is a conserved rostrocaudal gradient in duration of neuron production, coupled with distinct asymmetries in the patterns of axon extension and synaptogenesis on the same axis. A small set of conserved sensorimotor areas with well-defined thalamic input anchors the rostrocaudal axis. These core mechanisms organize the cortex into two contrasting topographic zones, while systematically amplifying hierarchical organization on the rostrocaudal axis in larger brains. Recent work has shown that variation in 'cognitive control' in multiple species correlates best with absolute brain size, and this may be the behavioral outcome of this progressive organizational change.
authors.affiliation: Behavioral and Evolutionary Neuroscience Group, Department of Psychology, Uris Hall, Cornell University, Ithaca, NY 14853, USA. Electronic address: blf2@cornell.edu.
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Finlay
authors.affiliation: Behavioral and Evolutionary Neuroscience Group, Department of Psychology, Uris Hall, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Uchiyama
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology; D005075:Biological Evolution; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*
keywords: axon arborization; cerebral cortex; evo-devo; feed-forward; rostrocaudal axis; topography