title: Applications of nanoparticles in treatment and diagnosis of leukemia.
abstract: The conventional chemotherapy for leukemia involves frequent dosing, severe side effects and lack of specificity of such anticancer drugs. The treatment with most of the anti-leukemic drugs would be improved if they were delivered to their biological targets through appropriate application of nanotechnology by manipulating at the molecular level. Nanoparticles in the recent years have shown tremendous application with respect to diagnosis and treatment of leukemia. The review specifically focuses on the use of nanoparticles for sustaining the release of anti-leukemic drugs and intracellular delivery of such nanoparticles. The review also highlights the application of nanoparticles in reversal of multidrug resistance.
authors.affiliation: Department of Pharmaceutics, Rajeev Gandhi College of Pharmacy, Salaiya, Via Danish Kunj, Kolar Road, Bhopal, 462042 M.P., India.
authors.forename: Govind
authors.initials: G
authors.lastname: Soni
authors.affiliation: Department of Pharmaceutics, Rajeev Gandhi College of Pharmacy, Salaiya, Via Danish Kunj, Kolar Road, Bhopal, 462042 M.P., India. Electronic address: khush.yadav@gmail.com.
authors.forename: Khushwant S
authors.initials: KS
authors.lastname: Yadav
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy*; D053758:Nanoparticles
chemical_list: D000970:Antineoplastic Agents
keywords: Cell lines; Diagnosis; Leukemia; Nanoparticles; Reversal of multidrug resistance; Treatment