title: Diterpenes from a Chinese collection of the brown alga Dictyota plectens.
abstract: Twenty-seven diterpenes of six chemical classes, including seven new diterpenes (1, 2, 6, 10, 11, 16, and 19), have been isolated from a collection of the brown alga Dictyota plectens from the South China Sea. The structures of the new diterpenes were elucidated by extensive spectroscopic analysis and by comparison with reported data. In the in vitro assays, 9, 12, 14, 16, and 22 showed inhibitory activity against HIV-1 replication with IC50 values of 16.1-30.5 μM, compounds 5, 13, 24, and 26 exhibited anti-H5N1 activity with inhibition rates of 50%-62% at 30.0 μM, and 12 and 24 also showed potent inhibition against LPS-induced NO production with inhibition rates of 90% and 86%, respectively, at 10.0 μM.
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University , Wenzhou 325035, People's Republic of China.
authors.forename: Shimiao
authors.initials: S
authors.lastname: Cheng
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Sun
authors.forename: Weiping
authors.initials: W
authors.lastname: Yuan
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Yuepiao
authors.initials: Y
authors.lastname: Cai
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
authors.forename: Kexin
authors.initials: K
authors.lastname: Huang
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
mesh_terms: D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015497:HIV-1 / Q000187:drug effects; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D008070:Lipopolysaccharides