title: Exosomes and other extracellular vesicles in host-pathogen interactions.
abstract: An effective immune response requires the engagement of host receptors by pathogen-derived molecules and the stimulation of an appropriate cellular response. Therefore, a crucial factor in our ability to control an infection is the accessibility of our immune cells to the foreign material. Exosomes-which are extracellular vesicles that function in intercellular communication-may play a key role in the dissemination of pathogen- as well as host-derived molecules during infection. In this review, we highlight the composition and function of exosomes and other extracellular vesicles produced during viral, parasitic, fungal and bacterial infections and describe how these vesicles could function to either promote or inhibit host immunity.
authors.affiliation: Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA schorey.1@nd.edu.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Schorey
authors.affiliation: Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Prachi P
authors.initials: PP
authors.lastname: Singh
authors.affiliation: Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Smith
mesh_terms: D000818:Animals; D015415:Biomarkers; D055354:Exosomes / Q000737:chemistry / Q000502:physiology; D006790:Host-Parasite Interactions / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000382:microbiology / Q000821:virology; D014612:Vaccines
chemical_list: D015415:Biomarkers; D014612:Vaccines
keywords: exosomes; extracellular vesicles; immunity; pathogens