title: Statins and alveolar bone resorption: a narrative review of preclinical and clinical studies.
abstract: BACKGROUND
  Tooth extraction and periodontal disease are both common clinical situations associated with alveolar bone loss.
  
  
  OBJECTIVE
  To analyze the reported results of in vivo studies investigating the effectiveness of statins to reduce alveolar bone resorption.
  
  
  METHODS
  Systematic electronic search of the MEDLINE-PubMed database.
  
  
  RESULTS
  A total of 21 studies met the inclusion criteria. This review showed that the use of statins reduced significantly alveolar bone resorption observed during periodontal disease and after tooth extraction. Oral administration was effective using high statin concentrations, although local administration using a biodegradable carrier was effective with lower concentrations. It was recently reported that statins were effective to reduce alveolar bone loss as an adjunct to scaling and root planing (SRP) in several clinical trials. Further studies are needed to confirm these promising results.
authors.affiliation: INSERM U1026, Tissue Bioengineering, 146 rue Léo-Saignat, F-33000 Bordeaux, France; University of Bordeaux, 146 rue Léo-Saignat, F-33000 Bordeaux, France; Department of Otolaryngology - Head and Neck Surgery, Univ. Bordeaux, Place Amélie Raba Léon, F-33000 Bordeaux, France. Electronic address: Erwan.de-mones-del-pujol@chu-bordeaux.fr.
authors.forename: Erwan
authors.initials: E
authors.lastname: de Monès
authors.affiliation: University of Bordeaux, 146 rue Léo-Saignat, F-33000 Bordeaux, France; Bordeaux University Hospital, CIC 1401, PTIB, Xavier Arnozan Hospital, F-33600 Pessac, France.
authors.forename: Silke
authors.initials: S
authors.lastname: Schlaubitz
authors.affiliation: INSERM U1026, Tissue Bioengineering, 146 rue Léo-Saignat, F-33000 Bordeaux, France; University of Bordeaux, 146 rue Léo-Saignat, F-33000 Bordeaux, France; Department of Dentistry, University of Bordeaux, Place Amélie Raba Léon, F-33000 Bordeaux, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Catros
authors.affiliation: INSERM U1026, Tissue Bioengineering, 146 rue Léo-Saignat, F-33000 Bordeaux, France; University of Bordeaux, 146 rue Léo-Saignat, F-33000 Bordeaux, France; Department of Dentistry, University of Bordeaux, Place Amélie Raba Léon, F-33000 Bordeaux, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fricain
mesh_terms: D000284:Administration, Oral; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors