title: MRI Texture Analysis and Diffusion Tensor Imaging in Chronic Right Hemisphere Ischemic Stroke.
abstract: OBJECTIVE
  Diffusion tensor imaging (DTI) is shown to reveal changes caused by cerebral infarction. The aim of this study is to reveal those changes also in the conventional magnetic resonance (MR) images using a quantitative image analysis method, texture analysis (TA).
  
  
  METHODS
  Thirty patients who had suffered their first ever infarction located on the right hemisphere underwent DTI and conventional MRI studies in the chronic phase. DTI parameters fractional anisotropy and mean diffusivity, as well as four second-order texture parameters were calculated. Interhemispheric differences and correlations between DTI and TA parameters were evaluated.
  
  
  RESULTS
  Our DTI findings supported earlier studies as fractional anisotropy values were lowered and mean diffusivity values elevated in the lesion site, and ipsilateral cerebral peduncle, thalamus, and centrum semiovale compared to the unaffected side. Textural homogeneity parameters showed lower and complexity parameters higher values in the lesion site and ipsilateral centrum semiovale compared to the contralateral hemisphere. Correlation between the two methods was found in ipsilateral mesencephalon.
  
  
  CONCLUSIONS
  In addition to DTI method, TA could assist in revealing the changes caused by infarction, also outside the lesion site. Damaged areas were found more heterogeneous and random in texture compared to unaffected sites.
authors.affiliation: Department of Radiology, Medical Imaging Center and Hospital Pharmacy, Tampere University Hospital, Tampere, Finland.|Department of Electronics and Communications Engineering, Tampere University of Technology, Tampere, Finland.
authors.forename: Minna
authors.initials: M
authors.lastname: Sikiö
authors.affiliation: Department of Radiology, Medical Imaging Center and Hospital Pharmacy, Tampere University Hospital, Tampere, Finland.|Department of Electronics and Communications Engineering, Tampere University of Technology, Tampere, Finland.
authors.forename: Paula
authors.initials: P
authors.lastname: Kölhi
authors.affiliation: Department of Radiology, Medical Imaging Center and Hospital Pharmacy, Tampere University Hospital, Tampere, Finland.
authors.forename: Pertti
authors.initials: P
authors.lastname: Ryymin
authors.affiliation: Department of Radiology, Medical Imaging Center and Hospital Pharmacy, Tampere University Hospital, Tampere, Finland.|Department of Electronics and Communications Engineering, Tampere University of Technology, Tampere, Finland.
authors.forename: Hannu J
authors.initials: HJ
authors.lastname: Eskola
authors.affiliation: Department of Radiology, Medical Imaging Center and Hospital Pharmacy, Tampere University Hospital, Tampere, Finland.|Medical School, University of Tampere, Tampere, Finland.
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000209:etiology* / Q000473:pathology*
keywords: Chronic infarction; diffusion tensor imaging; magnetic resonance imaging; texture analysis