title: Injectable tissue-engineered soft tissue for tissue augmentation.
abstract: Soft tissue augmentation is a process of implanting tissues or materials to treat wrinkles or soft tissue defects in the body. Over the years, various materials have evolved to correct soft tissue defects, including a number of tissues and polymers. Autogenous dermis, autogenous fat, autogenous dermis-fat, allogenic dermis, synthetic implants, and fillers have been widely accepted for soft tissue augmentations. Tissue engineering technology has also been introduced and opened a new venue of opportunities in this field. In particular, a long-lasting filler consisting of hyaluronic acid filler and living human mesenchymal cells called "injectable tissue-engineered soft tissue" has been created and applied clinically, as this strategy has many advantages over conventional methods. Fibroblasts and adipose-derived stromal vascular fraction cells can be clinically used as injectable tissue-engineered soft tissue at present. In this review, information on the soft tissue augmentation method using the injectable tissue-engineered soft tissue is provided.
authors.affiliation: Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Sung-Mi
authors.initials: SM
authors.lastname: Rhee
authors.affiliation: Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hi-Jin
authors.identifier: 0000-0002-9997-2736
authors.initials: HJ
authors.lastname: You
authors.affiliation: Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Seung-Kyu
authors.identifier: 0000-0002-2875-9276
authors.initials: SK
authors.lastname: Han
mesh_terms: D017667:Adipocytes / Q000637:transplantation; D000273:Adipose Tissue / Q000166:cytology; D001672:Biocompatible Materials; D003238:Connective Tissue / Q000601:surgery*; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D005145:Face; D005347:Fibroblasts / Q000637:transplantation; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007271:Injections, Intradermal; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells; D012867:Skin; D015595:Skin Aging; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D006820:Hyaluronic Acid
keywords: Cell Therapy; Soft Tissue; Tissue Engineering