title: Parents are interested in newborn genomic testing during the early postpartum period.
abstract: OBJECTIVE
  We surveyed parents to ascertain interest in newborn genomic testing and determine whether these queries would provoke refusal of conventional state-mandated newborn screening.
  
  
  METHODS
  After a brief genetics orientation, parents rated their interest in receiving genomic testing for their healthy newborn on a 5-point Likert scale and answered questions about demographics and health history. We used logistic regression to explore factors associated with interest in genomic testing and tracked any subsequent rejection of newborn screening.
  
  
  RESULTS
  We queried 514 parents within 48 hours after birth while still in hospital (mean age (SD) 32.7 (6.4) years, 65.2% female, 61.2% white, 79.3% married). Parents reported being not at all (6.4%), a little (10.9%), somewhat (36.6%), very (28.0%), or extremely (18.1%) interested in genomic testing for their newborns. None refused state-mandated newborn screening. Married participants and those with health concerns about their infant were less interested in newborn genomic testing (P = 0.012 and P = 0.030, respectively). Degree of interest for mothers and fathers was discordant (at least two categories different) for 24.4% of couples.
  
  
  CONCLUSIONS
  Interest in newborn genomic testing was high among parents of healthy newborns, and the majority of couples had similar levels of interest. Surveying parents about genomic sequencing did not prompt rejection of newborn screening.Genet Med 17 6, 501-504.
authors.affiliation: 1] Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA [2] Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA [3] Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Waisbren
authors.affiliation: 1] Harvard Medical School, Boston, Massachusetts, USA [2] Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Danielle K
authors.initials: DK
authors.lastname: Bäck
authors.affiliation: Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Christina
authors.identifier: 0000000264110482
authors.initials: C
authors.lastname: Liu
authors.affiliation: Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Sarah S
authors.identifier: 0000000317253445
authors.initials: SS
authors.lastname: Kalia
authors.affiliation: 1] Harvard Medical School, Boston, Massachusetts, USA [2] Department of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Ringer
authors.affiliation: 1] Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA [3] Manton Center for Orphan Diseases Research, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Ingrid A
authors.initials: IA
authors.lastname: Holm
authors.affiliation: 1] Harvard Medical School, Boston, Massachusetts, USA [2] Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA [3] Partners Personalized Medicine, Boston, Massachusetts, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015997:Neonatal Screening; D016017:Odds Ratio; D010290:Parents; D049590:Postpartum Period; D011795:Surveys and Questionnaires; D055815:Young Adult