title: A decade of norovirus genetic diversity in Belgium.
abstract: Outbreaks of norovirus-associated gastroenteritis occur during all seasons and in various locations, and are recognized as one of the most common causes of nonbacterial food-borne infections. The molecular epidemiology of norovirus infections has not been well characterized in Belgium. To study the incidence of norovirus infections and the nature of the circulating genotypes, 3080 specimens were collected from patients with acute gastroenteritis between 2004 and 2014. Norovirus was detected with RT-PCR in 554 samples (18%). The circulating strains were genotyped based on the variability in the 5' end of the capsid gene (region C). The GII.4 genotype, which is detected predominantly worldwide, was also the most prevalent genotype in our study (87%). This study shows a high frequency and genetic diversity of norovirus in patients with acute gastroenteritis in health care facilities in Flanders, Belgium.
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Laboratory of Clinical Virology, BE3000 Leuven, Belgium. Electronic address: Elke.Wollants@uzleuven.be.
authors.forename: Elke
authors.initials: E
authors.lastname: Wollants
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Laboratory of Clinical Virology, BE3000 Leuven, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: De Coster
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Laboratory of Clinical Virology, BE3000 Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Laboratory of Clinical Virology, BE3000 Leuven, Belgium.
authors.forename: Piet
authors.initials: P
authors.lastname: Maes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium / Q000453:epidemiology; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D017720:Molecular Epidemiology; D029322:Norovirus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D055815:Young Adult
keywords: Belgium; Genetic diversity; Norovirus