title: Comparison of two mouthrinses in relation to salivary flow and perceived dryness.
abstract: OBJECTIVE
  To compare measures of dry mouth following extended use of an alcohol-based mouthrinse (LISTERINE Antiseptic [LA]) and a non-alcohol-based mouthrinse (Crest Pro-Health Rinse [CPH]) on healthy adults with "normal" salivary flow.
  
  
  METHODS
  This single-site, randomized, observer-blinded, parallel study compared unstimulated whole salivary flow and perceived dryness following daily use at weeks 4 and 12 versus baseline. Noninferiority, between-treatment flow comparisons (0.15 mL/min margin), and between-treatment comparisons of the mean Bluestone Mouthfeel Questionnaire (BMQ) visual analog scale scores were made using analysis of covariance.
  
  
  RESULTS
  Measures of dry mouth were comparable between mouthrinses, as demonstrated by both noninferiority of LA versus CPH flow (P < .001) and no significant differences between groups in the BMQ measures at 4 or 12 weeks.
  
  
  CONCLUSIONS
  Extended use of an alcohol-based mouthrinse is no more likely to cause reduction in salivary flow or perceived dryness in individuals with normal salivary flow compared with a non-alcohol-based mouthrinse (CPH).
authors.affiliation: Assistant Professor, Department of Implant Dentistry & Periodontics; Assistant Director, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, USA. Electronic address: ark3@nyu.edu.
authors.forename: A R
authors.initials: AR
authors.lastname: Kerr
authors.affiliation: Research Coordinator, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Corby
authors.affiliation: Director, Johnson & Johnson Consumer and Personal Products Worldwide, Division of Johnson & Johnson Consumer Companies, Inc, New Brunswick, NJ, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kalliontzi
authors.affiliation: Director, Global Biostatistics, Johnson & Johnson Consumer and Personal Products Worldwide, Division of Johnson & Johnson Consumer Companies, Inc, New Brunswick, NJ, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: McGuire
authors.affiliation: Clinical Professor, Department of Oral & Maxillofacial Pathology, Radiology & Medicine; Director of the Oral Mucosal Disease Service, New York University College of Dentistry, New York, NY, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Charles
mesh_terms: D000328:Adult; D002594:Cetylpyridinium / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000009:adverse effects*; D012459:Salicylates / Q000009:adverse effects*; D012472:Salivation / Q000187:drug effects*; D011795:Surveys and Questionnaires; D013729:Terpenes / Q000009:adverse effects*; D014987:Xerostomia / Q000139:chemically induced*
chemical_list: C505193:Crest Pro-Health mouthrinse; D004338:Drug Combinations; D009067:Mouthwashes; D012459:Salicylates; D013729:Terpenes; C057473:Listerine; D002594:Cetylpyridinium