title: Understanding and treating cytopenia through mathematical modeling.
abstract: Here, we briefly review how the study of dynamic hematological diseases with mathematical modeling tools has led to a better understanding of the origin of some types of neutropenia and thrombocytopenia and to improved treatment strategies. In addition, we have briefly discussed how these models suggest improved ways to minimize and/or treat cytopenia induced by chemotherapy.
authors.affiliation: Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China, jzlei@tsinghua.edu.cn.
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Lei
authors.forename: Michael C
authors.initials: MC
authors.lastname: Mackey
mesh_terms: D000740:Anemia / Q000209:etiology / Q000628:therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D006402:Hematologic Diseases / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000628:therapy; D008954:Models, Biological; D009503:Neutropenia / Q000209:etiology / Q000628:therapy; D010507:Periodicity; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents