title: A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: an unusual case report.
abstract: Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition. This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.
authors.affiliation: Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
authors.forename: Bao-Chun
authors.initials: BC
authors.lastname: Lu
authors.affiliation: Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Yu
authors.affiliation: Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Shen
authors.affiliation: Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010641:Phenotype; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Adenosquamous carcinoma; Epithelial-mesenchymal transition; Histopathological types; Pancreatic tumors; Sarcomatoid change