title: Associations between metabolic and aerobic fitness parameters in patients with schizophrenia.
abstract: The primary aim was to determine whether the presence of metabolic syndrome (MetS) limits aerobic fitness in patients with schizophrenia. A secondary aim was to investigate the associations between aerobic fitness and MetS parameters. Aerobic fitness (expressed as predicted maximal oxygen uptake) was assessed using the Astrand-Rhyming test. Those with MetS (n = 19) were similar in age, sex, antipsychotic medication use, symptoms, and smoking behavior than those without (n = 31). Estimated maximal oxygen uptake was 21.4% lower (p = 0.001) in patients with MetS than in patients without MetS (29.5 ± 7.4 ml of O2/min/kg vs. 37.5 ± 8.2 ml of O2/min/kg, respectively). The estimated maximal oxygen uptake of the entire sample was correlated with waist circumference, the level of high-density lipoproteins, and fasting glucose. The current study demonstrates that the additive burden of MetS might place people with schizophrenia at increased risk for functional limitations in daily life activities.
authors.affiliation: *Department of Rehabilitation Sciences, KU Leuven, Belgium; †KU Leuven Department of Neurosciences, UPC KU Leuven (Campus Kortenberg), Belgium; ‡School of Health and Social Care, University of Greenwich, London, UK; §School of Psychiatry, University of New South Wales, Sydney, Australia; ∥Schizophrenia Research Unit, South Western Sydney Local Health District, Liverpool, Australia; ¶Musculoskeletal Division, The George Institute for Global Health, Sydney, Australia; and **School of Public Health, University of Sydney, Australia.
authors.forename: Davy
authors.initials: D
authors.lastname: Vancampfort
authors.forename: Hannes
authors.initials: H
authors.lastname: Guelinkcx
authors.forename: Michel
authors.initials: M
authors.lastname: Probst
authors.forename: Brendon
authors.initials: B
authors.lastname: Stubbs
authors.forename: Simon
authors.initials: S
authors.lastname: Rosenbaum
authors.forename: Philip B
authors.initials: PB
authors.lastname: Ward
authors.forename: Marc
authors.initials: M
authors.lastname: De Hert
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*; D055815:Young Adult