title: Antimalarial, antimicrobial, cytotoxic, DNA interaction and SOD like activities of tetrahedral copper(II) complexes.
abstract: The mononuclear copper(II) complexes with P, O-donor ligand and different fluoroquinolones have been synthesized and characterized by elemental analysis, electronic spectra, TGA, EPR, FT-IR and LC-MS spectroscopy. An antimicrobial efficiency of the complexes has been tested against five different microorganisms in terms of minimum inhibitory concentration (MIC) and displays very good antimicrobial activity. The binding strength and binding mode of the complexes with Herring Sperm DNA (HS DNA) have been investigated by absorption titration and viscosity measurement studies. The studies suggest the classical intercalative mode of DNA binding. Gel electrophoresis assay determines the ability of the complexes to cleave the supercoiled form of pUC19 DNA. Synthesized complexes have been tested for their SOD mimic activity using nonenzymatic NBT/NADH/PMS system and found to have good antioxidant activity. All the complexes show good cytotoxic and in vitro antimalarial activities.
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
authors.forename: Jugal V
authors.initials: JV
authors.lastname: Mehta
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Gajera
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India. Electronic address: jeenen@gmail.com.
authors.forename: Mohan N
authors.initials: MN
authors.lastname: Patel
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D001156:Artemia; D001769:Blood / Q000187:drug effects / Q000469:parasitology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; D056831:Coordination Complexes; D003603:Cytotoxins; D007364:Intercalating Agents; D003300:Copper; D004247:DNA
keywords: HS DNA; IC(50); LC(50); MIC; P, O-donor