title: Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails.
abstract: One of the major problems in orthopedic surgery is infection associated with implantation. The treatment is a very difficult and long-term process. A solution to this issue can be the use of implants which additionally constitute an antibiotic carrier preventing the development of an infection. Prototypes of biodegradable intramedullary nails made of three different composites with a poly(L-lactide) matrix were designed. The nails served as gentamicin sulfate (GS) carrier - an antibiotic commonly used in the treatment of osteomyelitis. The matrix was reinforced with carbon fibers (CF), alginate fibers (Alg) and magnesium alloy wires (Mg), as well as modified with bioactive particles of tricalcium phosphate (TCP) in various systems. In this way, novel, multi-phase and multifunctional degradable intramedullary nails were obtained. The tests demonstrated strong dependence between the type of the modifying phase introduced into the composite, and the rate of drug release. Introduction of gentamicin into the nail structure strengthened and prolonged antibacterial activity of the nails.
authors.affiliation: AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland. Electronic address: morawska@agh.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Morawska-Chochół
authors.affiliation: AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Domalik-Pyzik
authors.affiliation: AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Chłopek
authors.affiliation: AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Szaraniec
authors.affiliation: Warsaw University of Life Sciences - SGGW, Faculty of Veterinary Medicine, Department of Small Animal Diseases with Clinic, ul. Nowoursynowska 159c, 02-776 Warszawa, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Sterna
authors.affiliation: Warsaw University of Life Sciences - SGGW, Faculty of Veterinary Medicine, Department of Preclinical Sciences, ul. Ciszewskiego 8, 02-786 Warszawa, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rzewuska
authors.affiliation: Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, ul. Żeromskiego 116, 90-924 Lodz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Boguń
authors.affiliation: CJS Sp. z o. o., Gen. Jankego 134/1, 40-617 Katowice, Poland; IEE Group, Hannover, Germany.
authors.forename: Rafael
authors.initials: R
authors.lastname: Kucharski
authors.affiliation: AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biochemistry and Neurobiology, al. A. Mickiewicza 30, 30-059 Krakow, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Mielczarek
mesh_terms: D000464:Alginates / Q000737:chemistry; D000497:Alloys / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry*; D001858:Bone Nails / Q000382:microbiology; D002130:Calcium Phosphates / Q000737:chemistry; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010019:Osteomyelitis / Q000188:drug therapy / Q000517:prevention & control; D011091:Polyesters / Q000737:chemistry*; D019736:Prostheses and Implants; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000464:Alginates; D000497:Alloys; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D005839:Gentamicins; D006603:Hexuronic Acids; D011091:Polyesters; C033616:poly(lactide); D020723:Glucuronic Acid; C018392:tricalcium phosphate
keywords: Antibacterial activity; Composites; Degradable materials; Gentamicin release; Intramedullary nails; Poly(lactic acid)