title: Relationships of mean platelet volume and plasma thrombopoietin with glycocalicin levels in thrombocytopenic patients.
abstract: OBJECTIVE
  Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients.
  
  
  METHODS
  MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPT patients had PA-IgG <300% and glycocalicin <50% of control values.
  
  
  CONCLUSIONS
  MPV was higher in ITP than in HPT patients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
authors.affiliation: Russian Cardiology Research and Production Complex, Russian Ministry of Health, Moscow, Russian Federation.
authors.forename: Svetlana G
authors.initials: SG
authors.lastname: Khaspekova
authors.forename: Olga N
authors.initials: ON
authors.lastname: Shustova
authors.forename: Nina V
authors.initials: NV
authors.lastname: Golubeva
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Vasiliev
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Mazurov
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D013921:Thrombocytopenia / Q000097:blood*; D013926:Thrombopoietin / Q000097:blood*
chemical_list: D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin; D013926:Thrombopoietin