title: Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: comparison with F-18-FDG PET.
abstract: OBJECTIVE
  To determine the diagnostic performance of three-dimensional (3D) texture analysis (TA) of contrast-enhanced computed tomography (CE-CT) images for treatment response assessment in patients with Hodgkin lymphoma (HL), compared with F-18-fludeoxyglucose (FDG) positron emission tomography/CT.
  
  
  METHODS
  3D TA of 48 lymph nodes in 29 patients was performed on venous-phase CE-CT images before and after chemotherapy. All lymph nodes showed pathologically elevated FDG uptake at baseline. A stepwise logistic regression with forward selection was performed to identify classic CT parameters and texture features (TF) that enable the separation of complete response (CR) and persistent disease.
  
  
  RESULTS
  The TF fraction of image in runs, calculated for the 45° direction, was able to correctly identify CR with an accuracy of 75%, a sensitivity of 79.3%, and a specificity of 68.4%. Classical CT features achieved an accuracy of 75%, a sensitivity of 86.2%, and a specificity of 57.9%, whereas the combination of TF and CT imaging achieved an accuracy of 83.3%, a sensitivity of 86.2%, and a specificity of 78.9%.
  
  
  CONCLUSIONS
  3D TA of CE-CT images is potentially useful to identify nodal residual disease in HL, with a performance comparable to that of classical CT parameters. Best results are achieved when TA and classical CT features are combined.
authors.forename: Thomas
authors.initials: T
authors.lastname: Knogler
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
authors.forename: Knogler
authors.initials: K
authors.lastname: Thomas
authors.forename: Karem
authors.initials: K
authors.lastname: El-Rabadi
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
authors.forename: El-Rabadi
authors.initials: el-R
authors.lastname: Karem
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
authors.forename: Weber
authors.initials: W
authors.lastname: Michael
authors.forename: Georgios
authors.initials: G
authors.lastname: Karanikas
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
authors.forename: Karanikas
authors.initials: K
authors.lastname: Georgios
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
authors.forename: Marius E
authors.initials: ME
authors.lastname: Mayerhoefer
authors.forename: Mayerhoefer
authors.initials: M
authors.lastname: Marius Erik
mesh_terms: D000293:Adolescent; D000328:Adult; D055592:Biophysical Phenomena; D002648:Child; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D016015:Logistic Models; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18