title: Ultrasmall particles for Gd-MRI and (68) Ga-PET dual imaging.
abstract: Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd(3+) ] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[(68) Ga(3+) ] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after (68) Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Truillet
authors.affiliation: Radiochemistry Studies Laboratory, Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, National Center for Scientific Research 'Demokritos', Athens, Greece.
authors.forename: Penelope
authors.initials: P
authors.lastname: Bouziotis
authors.affiliation: Radiochemistry Studies Laboratory, Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, National Center for Scientific Research 'Demokritos', Athens, Greece.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Tsoukalas
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Brugière
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Martini
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brichart
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 21078, Dijon Cedex, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
authors.affiliation: CheMatech, 21000, Dijon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Boschetti
authors.affiliation: ICBMS, UMR 5246 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Darbost
authors.affiliation: ICBMS, UMR 5246 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bonnamour
authors.affiliation: Department of Cancer Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Stellas
authors.affiliation: Center for Experimental surgery, Clinical and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
authors.forename: Constantinos D
authors.initials: CD
authors.lastname: Anagnostopoulos
authors.affiliation: Department of Radiology, University of Athens Medical School, Areteion Hospital, Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Koutoulidis
authors.affiliation: Department of Radiology, University of Athens Medical School, Areteion Hospital, Athens, Greece.
authors.forename: Lia A
authors.initials: LA
authors.lastname: Moulopoulos
authors.affiliation: Matériaux Ingénierie et Science, INSA Lyon, UMR 5510, 69621, Villeurbanne Cedex, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.affiliation: ILM, UMR 5306 - Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000494:pharmacology; D000812:Anhydrides / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D005682:Gadolinium / Q000737:chemistry / Q000494:pharmacology; D005708:Gallium / Q000737:chemistry / Q000494:pharmacology; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: C572723:1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane; D000085:Acetates; D000812:Anhydrides; D003287:Contrast Media; C574967:DOTAGA-anhydride; D006573:Heterocyclic Compounds, 1-Ring; D005682:Gadolinium; D005708:Gallium
keywords: PET/MRI; multimodal imaging; nanoparticles