title: Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption.
abstract: The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10 weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added to milk. Groups 3 and 4 had 18% of estimated caloric intake from high fructose corn syrup or sucrose, respectively, added to the milk. Blood pressure and uric acid were determined prior to and after the 10-week intervention. There was no effect of sugar type on either blood pressure or uric acid (interaction P>.05), and a significant time effect for blood pressure was noted (P<.05). The authors conclude that 10 weeks of consumption of fructose at the 50th percentile level, whether consumed as pure fructose or with fructose-glucose-containing sugars, does not promote hyperuricemia or increase blood pressure.
authors.affiliation: Laboratory of Applied Physiology, Program in Physical Therapy, Department of Health Professions, University of Central Florida, Orlando, FL.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Angelopoulos
authors.forename: Joshua
authors.initials: J
authors.lastname: Lowndes
authors.forename: Stephanie
authors.initials: S
authors.lastname: Sinnett
authors.forename: James M
authors.initials: JM
authors.lastname: Rippe
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D004040:Dietary Carbohydrates / Q000009:adverse effects / Q000494:pharmacology*; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D033461:Hyperuricemia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016037:Single-Blind Method; D013395:Sucrose / Q000494:pharmacology; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
chemical_list: D004040:Dietary Carbohydrates; D014527:Uric Acid; D005632:Fructose; D013395:Sucrose