title: A hospital based study on reference range of serum prostate specific antigen levels.
abstract: OBJECTIVE
  Serum prostate specific antigen (PSA) levels are known to vary with race and ethnicity, environmental factors, lifestyle, metabolic and physiologic changes and advancing age. This study was designed to determine age specific serum PSA level in healthy Indian men and its comparison with that reported in different populations of the world.
  
  
  METHODS
  A total of 1300 adult men who attended Executive Health Check-up programme in a tertiary care hospital in Haryana, India, were included in the study. Forty seven men were excluded from the analysis because of urological conditions affecting PSA values. Overall, 1253 men were analyzed for age specific PSA values.
  
  
  RESULTS
  The age specific reference range of serum PSA values was 0.71 ng/ml in those younger than 40 yr; 0.85 ng/ml in 40-49 yr; 1.13 ng/ml in 50-59 yr group; 1.45 ng/ml in 60-69 yr group; 1.84 ng/ml in 70-79 yr group and 2.35 ng/ml in men older than 80 yr.
  
  
  CONCLUSIONS
  Our study provided the age-specific reference range of serum PSA in healthy men in India. The data suggested that the PSA levels were associated with increasing age.
authors.affiliation: Department of Clinical Laboratory, Medanta-The Medicity, Gurgaon, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Gupta
authors.forename: Deepa
authors.initials: D
authors.lastname: Gupta
authors.forename: Arun
authors.initials: A
authors.lastname: Raizada
authors.forename: Narmada Prasad
authors.initials: NP
authors.lastname: Gupta
authors.forename: Rajiv
authors.initials: R
authors.lastname: Yadav
authors.forename: Kamini
authors.initials: K
authors.lastname: Vinayak
authors.forename: Vijay
authors.initials: V
authors.lastname: Tewari
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006761:Hospitals; D006801:Humans; D007194:India; D007610:Kallikreins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen