title: Genetic susceptibility of early aseptic loosening after total hip arthroplasty: the influence of TIMP-1 gene polymorphism on Chinese Han population.
abstract: OBJECTIVE
  Genetic factor plays an important role in early failure of total hip arthroplasty (aseptic loosening) etiology, and TIMP-1 gene may be involved. The present study was conducted to reveal possible association between TIMP-1 polymorphisms with the risk of early failure of total hip arthroplasty (THA) (aseptic loosening).
  
  
  METHODS
  The TIMP-1 single nucleotide polymorphisms (SNPs) rs4898, rs6609533, and rs2070584 were genotyped in 59 subjects who were diagnosed as aseptic loosening after total hip arthroplasty and in 100 controls.
  
  
  RESULTS
  The TIMP-1 SNP rs4898 T allele in the case group was found to be 1.32 fold (P = 0.0013, 95% CI = 1.16 to 1.58) than the control group. Similarly, the G allele of rs6609533 was found to be associated with increased risk of aseptic loosening (OR = 1.78, 95% CI = 1.52 to 2.17, P < 0.0001). For SNP rs2070584, no statistical association was found (A vs. G, OR = 1.14, 95% CI = 0.97 to 1.40, P = 0.2028).
  
  
  CONCLUSIONS
  The results showed that the TIMP-1 SNPs rs4898 and rs6609533 were associated with the increased risk of early aseptic loosening susceptibility.
authors.affiliation: Department of Orthopaedics, Chinese People's Liberation Army 107 Hospital, No.7 South Zhichu Road, Yantai, 264002, China. fypan_2014@163.com.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Pan
authors.affiliation: Department of Radiology, Yantai Haigang Hospital, Yantai, Shandong, China. 2215935705@qq.com.
authors.forename: Shan
authors.initials: S
authors.lastname: Hua
authors.affiliation: Department of Orthopaedics, Chinese People's Liberation Army 107 Hospital, No.7 South Zhichu Road, Yantai, 264002, China. lgdmed@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Orthopaedics, Chinese People's Liberation Army 107 Hospital, No.7 South Zhichu Road, Yantai, 264002, China. sz_niu1970@163.com.
authors.forename: Dongjun
authors.initials: D
authors.lastname: Yin
authors.affiliation: Department of Orthopaedics, Chinese People's Liberation Army 107 Hospital, No.7 South Zhichu Road, Yantai, 264002, China. lihong_endo@163.com.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011475:Prosthesis Failure / Q000209:etiology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics*
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1