title: Preparation of poly(cyclooctene)-g-poly(ethylene glycol) (PCOE-g-PEG) graft copolymers with tunable PEG side chains via ROMP and its protein adsorption and platelet adhesion properties.
abstract: In our previous work [H. Shi, D. Shi et al., Polymer Chemistry 2(2011)679-684], polycyclooctene-g-PEG (PCOE-g-PEG) copolymers were synthesized via ring opening metathesis polymerization (ROMP) from PEG functionalized cyclic olefin macromonomers and cyclooctene. The grafting degree and the grafting site were easily controlled through the "grafting through" approach. The PCOE-g-PEG film surface was imparted excellent anti-protein adsorption properties. In that work, the molecular weight of PEG side chain was fixed at 750 g/mol and the neat PEG content in the copolymer was lower than 50 wt.%. In this work, both the effects of PEG side chain lengths (350 to 1000 g/mol) at a fixed PEG content (50 wt.%) and the neat PEG content (30 wt.% to 70 wt.%) at a fixed PEG molecular weight (750 g/mol) on the anti-protein adsorption and anti-platelet adhesion properties are studied. It is shown that the copolymer with 60 wt.% PEG side chains of 750 g/mol, where both PEG and PCOE form continuous morphology, is optimal to reduce the adsorption of both the bovine serum albumin (BSA) and platelet. When the PEG content reaches 70 wt.%, phase inversion happens. PEG is the continuous phase but PCOE becomes the dispersed phase. The surface roughness of the casting PCOE-g-PEG film increases. In this case, both BSA adsorption and platelet adhesion will slightly increase comparing to the sample with 60 wt.% PEG.
authors.affiliation: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China. Electronic address: deanshi2012@yahoo.com.
authors.forename: Dean
authors.initials: D
authors.lastname: Shi
authors.affiliation: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: shihc@ciac.ac.cn.
authors.forename: Hengchong
authors.initials: H
authors.lastname: Shi
authors.affiliation: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.
authors.forename: Yingkui
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Luan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: yinjh@ciac.ac.cn.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, PR China.
authors.forename: Robert K Y
authors.initials: RK
authors.lastname: Li
mesh_terms: D000327:Adsorption; D000818:Animals; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D034242:Cyclooctanes / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D034242:Cyclooctanes; D011108:Polymers; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols
keywords: Platelet adhesion; Poly(cyclooctene)-g-PEG; Protein adsorption; ROMP; Tunable