title: Spatiotemporal integration of developmental cues in neural development.
abstract: Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms of three classes of these cues: morphogenetic proteins, electrical activity, and the environment. We focus on second messenger dynamics and their role as integrators of the action of diverse cues, enabling plasticity in the process of neural development.
authors.affiliation: Department of Physiology & Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Sacramento, California, 95817.
authors.forename: Laura N
authors.initials: LN
authors.lastname: Borodinsky
authors.forename: Yesser H
authors.initials: YH
authors.lastname: Belgacem
authors.forename: Immani
authors.initials: I
authors.lastname: Swapna
authors.forename: Olesya
authors.initials: O
authors.lastname: Visina
authors.forename: Olga A
authors.initials: OA
authors.lastname: Balashova
authors.forename: Eduardo B
authors.initials: EB
authors.lastname: Sequerra
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Tu
authors.forename: Jacqueline B
authors.initials: JB
authors.lastname: Levin
authors.forename: Kira A
authors.initials: KA
authors.lastname: Spencer
authors.forename: Patricio A
authors.initials: PA
authors.lastname: Castro
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Hamilton
authors.forename: Sangwoo
authors.initials: S
authors.lastname: Shim
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003463:Cues; D006801:Humans; D009420:Nervous System / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D058953:Neural Stem Cells / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
keywords: calcium; electrical activity; environmental factors; morphogenetic proteins; neuronal differentiation