title: Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
abstract: Faithful chromosome segregation during mitosis is essential for genome integrity and is mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules through kinetochores. Errors in kinetochore-microtubule (k-MT) attachment that could cause chromosome mis-segregation are frequent and are corrected by the dynamic turnover of k-MT attachments. Thus, regulating the rate of spindle microtubule attachment and detachment to kinetochores is crucial for mitotic fidelity and is frequently disrupted in cancer cells displaying chromosomal instability. A model based on homeostatic principles involving receptors, a core control network, effectors and feedback control may explain the precise regulation of k-MT attachment stability during mitotic progression to ensure error-free mitosis.
authors.affiliation: Department of Biochemistry, The Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755, USA, and at the Norris Cotton Cancer Center, Lebanon, New Hampshire 03766, USA.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Godek
authors.affiliation: Department of Biochemistry, The Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755, USA, and at the Norris Cotton Cancer Center, Lebanon, New Hampshire 03766, USA.
authors.forename: Lilian
authors.initials: L
authors.lastname: Kabeche
authors.affiliation: Department of Biochemistry, The Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755, USA, and at the Norris Cotton Cancer Center, Lebanon, New Hampshire 03766, USA.
authors.forename: Duane A
authors.initials: DA
authors.lastname: Compton
mesh_terms: D000818:Animals; D043171:Chromosomal Instability; D020090:Chromosome Segregation; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology