title: Hyperthyroid and hypothyroid status was strongly associated with gout and weakly associated with hyperuricaemia.
abstract: OBJECTIVE
  The aim of this study was to estimate the risk of hyperuricaemia and gout in people with hypothyroid or hyperthyroid status.
  
  
  METHODS
  This study analyzed data from individuals who participated in health screening programs at Chang Gung Memorial Hospital in northern Taiwan (2000-2010). Participants were categorized as having euthyroid, hypothyroid, or hyperthyroid status according to their thyroid-stimulating hormone (TSH) levels. Multinomial logistic regression models were used to calculate the odds ratios (95% CI) for hyperuricaemia and gout in participants with thyroid dysfunction compared to euthyroid participants.
  
  
  RESULTS
  A total of 87,813 (euthyroid, 83,502; hypothyroid, 1,460; hyperthyroid, 2,851) participants were included. The prevalence of hyperuricaemia was higher in hyperthyroid subjects (19.4%) than in euthyroid subjects (17.8%) but not in hypothyroid subjects (19.3%). The prevalence of gout was significantly higher in both hypothyroid (6.0%) and hyperthyroid (5.3%) subjects than in euthyroid subjects (4.3%). In men, hypothyroid or hyperthyroid status was not associated with hyperuricaemia. However, hypothyroid or hyperthyroid status was associated with ORs (95% CI) of 1.47 (1.10-1.97) and 1.37 (1.10-1.69), respectively, for gout. In women, hypothyroid status was not associated with hyperuricaemia or gout. However, hyperthyroid status was associated with ORs (95% CI) of 1.42 (1.24-1.62) for hyperuricaemia and 2.13 (1.58-2.87) for gout.
  
  
  CONCLUSIONS
  Both hyperthyroid and hypothyroid status were significantly associated with gout and weakly associated with hyperuricaemia. A thyroid function test for gout patients may by warranted.
authors.affiliation: Department of Public Health, & Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Lai-Chu
authors.initials: LC
authors.lastname: See
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Kuo
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Kuang-Hui
authors.initials: KH
authors.lastname: Yu
authors.affiliation: Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Shue-Fen
authors.initials: SF
authors.lastname: Luo
authors.affiliation: Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: I-Jun
authors.initials: IJ
authors.lastname: Chou
authors.affiliation: Health Evaluation Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; First Division of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Yu-Shien
authors.initials: YS
authors.lastname: Ko
authors.affiliation: Department of Public Health, & Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Meng-Jiun
authors.initials: MJ
authors.lastname: Chiou
authors.affiliation: Department of Public Health, & Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jia-Rou
authors.initials: JR
authors.lastname: Liu
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006073:Gout / Q000453:epidemiology*; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology*; D033461:Hyperuricemia / Q000453:epidemiology*; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013960:Thyroid Function Tests