title: Novel alginate hydrogel core-shell systems for combination delivery of ranitidine HCl and aceclofenac.
abstract: A novel hydrogel system was successfully developed based on core-shell approach for the delivery of ranitidine HCl and aceclofenac. Aceclofenac-loaded alginate microspheres coated with eudragit L-100 was used as core material and that of freeze-thaw cross-linked chitosan-PVA gels containing ranitidine HCl served as the shell-forming material. The alginate microspheres coated with eudragit L-100 showed drug encapsulation efficiency of 56.06±1.12 to 68.03±2.16% and had average particle sizes of 551.29±25.92 to 677.18±27.05 μm. The viscosity of chitosan-PVA gels ranged between 505.74±1.04 and 582.41±2.09 cps. The formulations were characterized by FTIR, SEM and polarized microscopy analyses. The release of ranitidine HCl was comparatively higher in acidic medium (pH 1.2) than in alkaline medium (pH 7.4). The release of aceclofenac became slower in alkaline medium (pH 7.4) and continued up to 3.5 h. Super case-II transport mechanism was assumed for the release of ranitidine HCl in both media; whereas non-Fickian (anomalous) diffusion mechanism predominated in the release of aceclofenc. Thus, hydrogel-based core-shell formulations were found suitable for simultaneous delivery of aceclofenac and ranitidine HCl which could minimize the chances of excessive gastric acid secretion through suitable ranitidine HCl release in gastric region.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, WB, India. Electronic address: janapharmacy@rediffmail.com.
authors.forename: Sougata
authors.initials: S
authors.lastname: Jana
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, WB, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Samanta
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, WB, India.
authors.forename: Kalyan Kumar
authors.initials: KK
authors.lastname: Sen
authors.affiliation: Department of Chemistry, V.E.C, Sarguja University, Ambikapur 497001, CG, India.
authors.forename: Subrata
authors.initials: S
authors.lastname: Jana
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry; D011899:Ranitidine / Q000008:administration & dosage*; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011109:Polymethacrylic Acids; D004008:Diclofenac; C038300:methylmethacrylate-methacrylic acid copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011899:Ranitidine; D020723:Glucuronic Acid; C056498:aceclofenac
keywords: Dual drug delivery, Aceclofenac; Hydrogel; Ranitidine HCl