title: THPO-MPL pathway and bone marrow failure.
abstract: Single or multilineage bone marrow failure can be a serious health problem caused by hereditary and non-hereditary causes such as exposure to drugs or environmental toxins. Normal hematopoiesis requires the integrity of several pathways including the THPO-MPL pathway. Over the last two decades, significant advances in the understanding of normal and abnormal functions of this and related pathways have led to novel diagnostic and therapeutic options.
authors.affiliation: Department of Genetics, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: madasouki@kfshrc.edu.sa.
authors.forename: Majed
authors.initials: M
authors.lastname: Dasouki
authors.affiliation: Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Irfan
authors.initials: I
authors.lastname: Saadi
authors.affiliation: Adult Hematology/Bone Marrow Transplantation, Oncology Center, MBC-64, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
authors.forename: Syed O
authors.initials: SO
authors.lastname: Ahmed
mesh_terms: D001853:Bone Marrow / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D013926:Thrombopoietin / Q000378:metabolism*
chemical_list: D013926:Thrombopoietin
keywords: Aplastic anemia; Bone marrow failure; CALR (calreticulin); Eltrombopag; JAK (Janus Kinase); MPL (myeloproliferative leukemia virus); Myelofibrosis; Romiplostim; THPO (Thrombopoietin); Thrombocythemia