title: Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma.
abstract: OBJECTIVE
  To determine relationships between spectral-domain optical coherence tomography (SD-OCT) derived regional damage to the retinal ganglion cell-axonal complex (RGC-AC) and visual thresholds for each location of the Humphrey 24-2 visual field, in all stages of open-angle glaucoma.
  
  
  METHODS
  Patients with early, moderate, and advanced glaucoma were recruited from a tertiary glaucoma clinic. Humphrey 24-2 and 9-field Spectralis SD-OCT were acquired for each subject. Individual OCT volumes were aligned, nerve fiber layer (NFL), ganglion cell and inner plexiform layers (GCL+IPL) cosegmented. These layers were then partitioned into 54 sectors corresponding to the 24-2 grid. A Support Vector Machine was trained independently for each sector to predict the sector threshold, using these structural properties.
  
  
  RESULTS
  One hundred twenty-two consecutive subjects, 43 early, 39 moderate, and 40 advanced, glaucoma were included (122 eyes). Average correlation coefficient (R) was 0.68 (0.47-0.82), and average root mean square error (RMSE) was 6.92 dB (3.93-8.68 dB). Prediction performance averaged over the entire field, superior hemifield, and inferior hemifield had R (RMSE) values of 0.77 (3.76), 0.80 (5.05), and 0.84 (3.80) dB, respectively.
  
  
  CONCLUSIONS
  Predicting individual 24-2 visual field thresholds from structural information derived from nine-field SD-OCT local NFL and GCL+IPL thicknesses using the RGC-AC concept is feasible, showing the potential for the predictive ability of SD-OCT structural information for visual function. Ultimately, it may be feasible to complement and reduce the burden of subjective visual field testing in glaucoma patients with predicted function derived objectively from OCT.
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Bogunović
authors.affiliation: Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Young H
authors.initials: YH
authors.lastname: Kwon
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Adnan
authors.initials: A
authors.lastname: Rashid
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Kyungmoo
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Critser
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Mona K
authors.initials: MK
authors.lastname: Garvin
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Milan
authors.initials: M
authors.lastname: Sonka
authors.affiliation: Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Abràmoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: OCT; ganglion cell; image analysis; perimetry; visual field