title: Novel insights into the mitochondrial permeability transition.
abstract: Alavian and colleagues recently provided further evidence in support of the notion that the c subunit of the mitochondrial F1FO ATP synthase constitutes the long-sought pore-forming unit of the supramolecular complex responsible for the so-called 'mitochondrial permeability transition' (MPT). Besides shedding new light on the molecular mechanisms that underlie the MPT, these findings corroborate the notion that several components of the cell death machinery, including cytochrome c and the F1FO ATP synthase, mediate critical metabolic activities.
authors.affiliation: a Section of Pathology , Oncology and Experimental Biology ; Laboratory for Technologies of Advanced Therapies (LTTA); Department of Morphology , Surgery and Experimental Medicine ; University of Ferrara ; Ferrara , Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonora
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Bravo-San Pedro
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
mesh_terms: D000818:Animals; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism; D008954:Models, Biological
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D025261:Mitochondrial Proton-Translocating ATPases
keywords: AIFM1, apoptosis-inducing factor mitochondrion-associated, 1; ATP5G, ATP synthase, H+ transporting, mitochondrial FO complex, subunit C; BCL-XL; CYPD cyclophilin D; CYTC holocytochrome c; CsA, cyclosporin A; IMM, inner mitochondrial membrane; MCU, mitochondrial calcium uniporter; MPT, mitochondrial permeability transition; PPIF, peptidylprolyl isomerase F; PTPC, permeability transition pore complex; RCD, regulated cell death; SMV, submitochondrial vesicle.; apoptosis; cyclophilin D; cyclosporin A; necrosis; permeability transition pore complex; Δψm; mitochondrial transmembrane potential