title: The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes.
abstract: Bacteria hijack eukaryotic cells by injecting virulence effectors into host cytosol with a type III secretion system (T3SS). Effectors are targeted with their cognate chaperones to hexameric T3SS ATPase at the bacterial membrane's cytosolic face. In this issue of the Journal of Bacteriology, Roblin et al. (P. Roblin, F. Dewitte, V. Villeret, E. G. Biondi, and C. Bompard, J Bacteriol 197:688-698, 2015, http://dx.doi.org/10.1128/JB.02294-14) show that the T3SS chaperone SigE of Salmonella can form hexameric rings rather than dimers when bound to its cognate effector, SopB, implying a novel multimeric association for chaperone/effector complexes with their ATPase.
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
authors.forename: Chi-Lin
authors.identifier: http://orcid.org/0000-0002-0365-2405
authors.initials: CL
authors.lastname: Tsai
authors.affiliation: Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Brianne J
authors.initials: BJ
authors.lastname: Burkinshaw
authors.affiliation: Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada ncjs@mail.ubc.ca JATainer@lbl.gov.
authors.forename: Natalie C J
authors.initials: NC
authors.lastname: Strynadka
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA ncjs@mail.ubc.ca JATainer@lbl.gov.
authors.forename: John A
authors.initials: JA
authors.lastname: Tainer
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism*; D018832:Molecular Chaperones / Q000737:chemistry* / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000378:metabolism*; D012808:Sigma Factor / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones; D012808:Sigma Factor; C060972:SopB protein, Bacteria; C111259:sigE protein, Bacteria