title: Community-driven research on environmental sources of H. pylori infection in arctic Canada.
abstract: The role of environmental reservoirs in H. pylori transmission remains uncertain due to technical difficulties in detecting living organisms in sources outside the stomach. Residents of some Canadian Arctic communities worry that contamination of the natural environment is responsible for the high prevalence of H. pylori infection in the region. This analysis aims to estimate associations between exposure to potential environmental sources of biological contamination and prevalence of H. pylori infection in Arctic Canada. Using data from 3 community-driven H. pylori projects in the Northwest and Yukon Territories, we estimated effects of environmental exposures on H. pylori prevalence, using odds ratios (OR) and 95% confidence intervals (CI) from multilevel logistic regression models to adjust for household and community effects. Investigated exposures include: untreated drinking water; livestock; dogs; cats; mice or mouse droppings in the home; cleaning fish or game. Our analysis did not identify environmental exposures associated clearly with increased H. pylori prevalence, except any exposure to mice or mouse droppings (OR = 4.6, CI = 1.2-18), reported by 11% of participants. Our multilevel models showed H. pylori clustering within households, but environmental exposures accounted for little of this clustering; instead, much of it was accounted for by household composition (especially: having infected household members; number of children). Like the scientific literature on this topic, our results do not clearly implicate or rule out environmental reservoirs of H. pylori; thus, the topic remains a priority for future research. Meanwhile, H. pylori prevention research should seek strategies for reducing direct transmission from person to person.
authors.affiliation: a School of Public Health ; University of Alberta ; Edmonton , Canada.
authors.forename: Emily V
authors.initials: EV
authors.lastname: Hastings
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yasui
authors.forename: Patrick
authors.initials: P
authors.lastname: Hanington
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Goodman
mesh_terms: D000818:Animals; D001110:Arctic Regions; D002170:Canada / Q000453:epidemiology; D002415:Cats; D004285:Dogs; D004781:Environmental Exposure; D004783:Environmental Microbiology; D005192:Family Health; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D008297:Male; D051379:Mice; D015233:Models, Statistical; D015995:Prevalence
keywords: Arctic; Canada; Helicobacter pylori; environmental exposures; epidemiology; transmission