title: Differentiation of benign angiomatous and microcystic meningiomas with extensive peritumoral edema from high grade meningiomas with aid of diffusion weighted MRI.
abstract: OBJECTIVE
  To determine whether angiomatous and microcystic meningiomas which mimic high grade meningiomas based on extent of peritumoral edema can be reliably differentiated as low grade tumors using normalized apparent diffusion coefficient (ADC) values.
  
  
  METHODS
  Preoperative magnetic resonance imaging (MRI) of seventy patients with meningiomas was reviewed. Morphologically, the tumors were divided into 3 groups. Group 1 contained 12 pure microcystic, 3 pure angiomatoid and 7 mixed angiomatoid and microcystic tumors. Group 2 included World Health Organization (WHO) grade II and WHO grade III tumors, of which 28 were atypical and 9 were anaplastic meningiomas. Group 3 included WHO grade I tumors of morphology different than angiomatoid and microcystic. Peritumoral edema, normalized ADC, and cerebral blood volume (CBV) were obtained for all meningiomas.
  
  
  RESULTS
  Edema index of tumors in group 1 and group 2 was significantly higher than in group 3. Normalized ADC value in group 1 was higher than in group 2, but not statistically significant between groups 1 and 3. CBV values showed no significant group differences.
  
  
  CONCLUSIONS
  A combination of peritumoral edema index and normalized ADC value is a novel approach to preoperative differentiation between true aggressive meningiomas and mimickers such as angiomatous and microcystic meningiomas.
authors.affiliation: Department of Radiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Avetis
authors.initials: A
authors.lastname: Azizyan
authors.affiliation: Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Eboli
authors.affiliation: Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Doniel
authors.initials: D
authors.lastname: Drazin
authors.affiliation: Biostatistics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: James
authors.initials: J
authors.lastname: Mirocha
authors.affiliation: Department of Radiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Maya
authors.affiliation: Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Serguei
authors.initials: S
authors.lastname: Bannykh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D011859:Radiography