title: Influence of chemotherapy for lymphoma in canine parvovirus DNA distribution and specific humoral immunity.
abstract: In man, the combination of cancer and its treatment increases patients' susceptibility to opportunistic infections, due to immune system impairment. In veterinary medicine little information is available concerning this issue. In order to evaluate if a similar dysfunction is induced in small animals undergoing chemotherapy, we assessed the complete blood count, leukocytic, plasma and fecal canine parvovirus (CPV) viral load, and anti-CPV protective antibody titers, in dogs with lymphoma treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) protocol, before and during chemotherapy. There was no evidence of decreased immune response, either at admission or after two chemotherapy cycles, indicating that the previously established immunity against CPV was not significantly impaired, supporting the idea that immunosuppression as a result of hematopoietic neoplasms and their treatment in dogs requires further investigation and conclusions cannot be extrapolated from human literature.
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: marta.a.elias@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Elias
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: anaduarte@fmv.ulisboa.pt.
authors.forename: A
authors.initials: A
authors.lastname: Duarte
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: pinanunes@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Nunes
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal; Faculty of Veterinary Medicine Teaching Hospital, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: dermavet@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Lourenço
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: bsaobraz@fmv.ulisboa.pt.
authors.forename: B S
authors.initials: BS
authors.lastname: Braz
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal; Faculty of Veterinary Medicine Teaching Hospital, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: gonvic@sapo.pt.
authors.forename: G
authors.initials: G
authors.lastname: Vicente
authors.affiliation: Oncovet, Avenida de Berna, 35, 1050-038 Lisbon, Portugal. Electronic address: oncovet@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Henriques
authors.affiliation: Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal. Electronic address: ltavares@fmv.ulisboa.pt.
authors.forename: L
authors.initials: L
authors.lastname: Tavares
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols; D003520:Cyclophosphamide / Q000008:administration & dosage; D004279:DNA, Viral / Q000097:blood*; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects*; D008223:Lymphoma / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000821:virology; D017993:Parvovirus, Canine / Q000276:immunology / Q000472:pathogenicity; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone; D013045:Species Specificity; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D011241:Prednisone
keywords: CHOP; Canine lymphoma; Canine parvovirus; Dog; Immunosuppression