title: Preoperative serum levels of mesothelin in patients with colon cancer.
abstract: BACKGROUND
  Screening for biochemical markers is important for diagnosing colon cancer. In this study, the reliability of serum mesothelin levels as a potential diagnostic and screening instrument was evaluated concerning colon cancer.
  
  
  METHODS
  Ninety-five patients who had undergone colonoscopic examination and who were diagnosed with colon cancer were included in the study. The serum mesothelin levels were measured with the ELISA kits and were evaluated in terms of significant difference when compared between colon cancer and control group.
  
  
  RESULTS
  Patients with colon cancer had significantly higher mesothelin serum levels (P < 0.001) than the control groups. We found significant associations between serum levels and tumor grade, perineural invasion, and vascular invasion (resp., P < 0.001).
  
  
  CONCLUSIONS
  Evaluating the serum levels of mesothelin has a potential to detect and screen the colon cancer in affected patients. Our data suggest that mesothelin exhibits effects towards colon cancer and serves as a biomarker for this deadly disease.
authors.affiliation: Şişli Hamidiye Etfal Training and Research Hospital General Surgery Clinic, Istanbul, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Bostancı
authors.affiliation: Department of General Surgery, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Kemik
authors.affiliation: Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Ahu
authors.initials: A
authors.lastname: Kemik
authors.affiliation: Şişli Hamidiye Etfal Training and Research Hospital General Surgery Clinic, Istanbul, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Battal
authors.affiliation: Şişli Hamidiye Etfal Training and Research Hospital General Surgery Clinic, Istanbul, Turkey.
authors.forename: Uygar
authors.initials: U
authors.lastname: Demir
authors.affiliation: Department of Biostatistics, Istanbul University Medical Faculty, Istanbul, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Purisa
authors.affiliation: Department of Radiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Alpaslan
authors.identifier: 0000-0002-8796-988X
authors.initials: A
authors.lastname: Yavuz
authors.affiliation: Şişli Hamidiye Etfal Training and Research Hospital General Surgery Clinic, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mihmanlı
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D058851:GPI-Linked Proteins / Q000097:blood*; D006801:Humans; D000090204:Mesothelin; D008875:Middle Aged; D060787:Neoplasm Grading; D057234:Preoperative Period; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D000090204:Mesothelin