title: Oxidative nucleophilic cyclization of 2-alkynylanilines with thiophenols under metal-free conditions.
abstract: An oxidative nucleophilic cyclization of 2-alkynylanilines with thiophenols under metal-free conditions was developed. The one-pot two-step reaction involves a PhI(OAc)2-mediated oxidative dearomatization and a Brønsted acid promoted nucleophilic cyclization. DFT calculations were performed to understand the reaction pathway.
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai, 200433, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Han
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Li
authors.forename: Renhua
authors.initials: R
authors.lastname: Fan
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*; D011789:Quantum Theory; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D008670:Metals; D010636:Phenols; D013438:Sulfhydryl Compounds; C042983:thiophenol