title: Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers.
abstract: OBJECTIVE
  To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.
  
  
  METHODS
  Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk (4W group) or 2 wk (2W group). At 4 wk after ESD, we measured the size of the artificial ulcers by endoscopy and determined the ulcer healing rate, compared with the size of the ESD specimens. This randomized controlled trial study was approved by our ethics committee and registered in the UMIN Clinical Trial Registry.
  
  
  RESULTS
  A total of 60 consecutive patients were included in the study. All patients received rebamipide 300 mg per day for 4 wk. One patient in 2W group who showed bleeding within two weeks and received endoscopic treatment was excluded from further analysis. The numbers of patients with ulcers in the healing/scar stage in the 2W and 4W groups at 4 wk after ESD were 20/6 and 28/5, respectively, with no significant difference. The ulcer healing rate in the 2W and 4W groups were 96.1% [95% confidence interval (CI): 94.6%-97.55] vs 94.8% (95%CI: 92.6%-97.1%), respectively, with no statistical difference (UMIN000006951).
  
  
  CONCLUSIONS
  Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers.
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsumura
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Okimoto
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Oyamada
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Saito
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Minemura
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Maruoka
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Nakagawa
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Katsuno
authors.affiliation: Makoto Arai, Tomoaki Matsumura, Kenichiro Okimoto, Arata Oyamada, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Takeshi Tanaka, Tomoo Nakagawa, Tatsuro Katsuno, Osamu Yokosuka, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004210:Dissection / Q000009:adverse effects* / Q000379:methods; D004334:Drug Administration Schedule; D064098:Esomeprazole / Q000008:administration & dosage*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005773:Gastroscopy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D014456:Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D054328:Proton Pump Inhibitors; D064098:Esomeprazole
keywords: Endoscopic submucosal dissection; Esomeprazole; Proton pump inhibitor; Randomized control trial; Rebamipide