title: Safety and efficacy of the vibrating capsule, an innovative non-pharmacological treatment modality for chronic constipation.
abstract: BACKGROUND
  Constipation is a common disorder. Because the prevalence is high and the satisfaction level with currently available treatment is low, there is an unmet need for innovative treatment. We assessed the safety and efficacy of the Vibrant Capsule, a non-pharmacological device that is assumed to induce a normal peristaltic wave in the large intestine to alleviate constipation.
  
  
  METHODS
  Two animal safety studies and a safety study on healthy volunteers were conducted, followed by a prospective, non-randomized, open-label, single group assignment, safety and efficacy study. The latter was conducted among 26 patients who ingested the capsule twice weekly for a study period of 7.5 weeks, after a run-in period of 2 weeks without usual treatment for constipation.
  
  
  RESULTS
  In the studies on animals and healthy volunteers, there were no adverse events. Twenty-eight patients began the clinical trial and 26 completed it (25 women). The mean age was 47.0 ± 12.6 years (range: 19-65). The two dropouts, who completed the safety phase, and the 26 who completed the entire study expelled the capsule without difficulty. Twelve participants reported 27 adverse events, none serious, and all transient. There was a significant increase of 1.60 ± 1.09 in the mean number of bowel movements/week from 2.19 ± 0.67 to 3.79 ± 1.31 (p < 0.001). This increase was seen in 23 of the 26 patients (88.5%). The mean number of spontaneous bowel movements for the study group increased in each treatment week compared to baseline.
  
  
  CONCLUSIONS
  The Vibrant Capsule is safe and potentially effective in the treatment of constipation, justifying randomized controlled studies.
authors.affiliation: Department of Gastroenterology and Hepatology, The Tel-Aviv Sourasky Medical Center and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Ron
authors.forename: Z
authors.initials: Z
authors.lastname: Halpern
authors.forename: R
authors.initials: R
authors.lastname: Safadi
authors.forename: R
authors.initials: R
authors.lastname: Dickman
authors.forename: R
authors.initials: R
authors.lastname: Dekel
authors.forename: A D
authors.initials: AD
authors.lastname: Sperber
mesh_terms: D000328:Adult; D000818:Animals; D002214:Capsules; D002908:Chronic Disease; D003248:Constipation / Q000628:therapy*; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome; D014732:Vibration / Q000009:adverse effects* / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D002214:Capsules
keywords: IBS; Vibrant; capsule; constipation; treatment