title: Differential scanning calorimetry (DSC) as a tool for probing the reactivity of polyynes relevant to hexadehydro-Diels-Alder (HDDA) cascades.
abstract: The differential scanning calorimetry (DSC) behavior of a number of alkyne-rich compounds is described. The DSC trace for each compound exhibits an exothermic event at a characteristic onset temperature. For the tri- and tetraynes whose [4 + 2] HDDA reactivity in solution has been determined, these onset temperatures show a strong correlation with the cyclization activation energy. The studies reported here exemplify how the data available through this operationally simple analytical technique can give valuable insights into the thermal behavior of small molecules.
authors.affiliation: Department of Chemistry, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Woods
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hoye
mesh_terms: D002152:Calorimetry, Differential Scanning; D003500:Cyclization; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D053279:Polyynes / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D053279:Polyynes