title: Probing disease-related proteins with fluorogenic composite materials.
abstract: Construction of composite materials based on the self-assembly of fluorescently labeled biomolecules with a variety of micro- or nano-quenching materials (by the Förster Resonance Energy Transfer mechanism) for the fluorogenic recognition of disease-related proteins has become a dynamic research topic in the field of fluorescence recognition. Here we summarize the recent progress on the composition of fluorescence dye-labeled biomolecules including sugars, peptides and nucleotides with organic (graphene and carbon nanotubes) and inorganic (gold nanoparticles) materials. Their application in the fluorescence detection of proteins and enzymes on both the molecular and cellular levels is discussed. Perspectives are proposed with respect to the future directions of employing these composite materials in the recognition of pathological proteins.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology (ECUST), 130 Meilong Rd., Shanghai 200237, PR China. mrs_guorongchen@ecust.edu.cn.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), 189 Guo Shoujing Rd., Shanghai 201203, PR China. jli@simm.ac.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), 189 Guo Shoujing Rd., Shanghai 201203, PR China. jli@simm.ac.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology (ECUST), 130 Meilong Rd., Shanghai 200237, PR China. mrs_guorongchen@ecust.edu.cn.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D011506:Proteins / Q000032:analysis / Q000737:chemistry
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes; D011506:Proteins; D006108:Graphite