title: Parathyroid Allotransplant for Persistent Hypocalcaemia: A New Technique Involving Short-Term Culture.
abstract: OBJECTIVE
  To develop a new parathyroid allotransplant method for the treatment of permanent hypoparathyroidism.
  
  
  METHODS
  Parathyroid cells 50 × 10(6) derived from a parathyroid hyperplasia patient were transferred to a 61-year-old patient who had thyroidectomy 17 years earlier, allowing to papillary thyroid cancer; he was admitted to our outpatient clinic with symptomatic chronic hypocalcemia. Cell isolation, cryopreservation, and culturing were conducted according to a new protocol.
  
  
  RESULTS
  During a follow-up of 5 months, the patient had no complications that could indicate rejection, and clinical symptoms completely resolved without requiring any drug supplementation.
  
  
  CONCLUSIONS
  Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia.
authors.affiliation: From the Department of General Surgery, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Aysan
authors.forename: Ulkan
authors.initials: U
authors.lastname: Kilic
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gok
authors.forename: Burcugul
authors.initials: B
authors.lastname: Altug
authors.forename: Cilem
authors.initials: C
authors.lastname: Ercan
authors.forename: Cemile
authors.initials: C
authors.lastname: Kesgin Toka
authors.forename: Ufuk Oguz
authors.initials: UO
authors.lastname: Idiz
authors.forename: Mahmut
authors.initials: M
authors.lastname: Muslumanoglu
mesh_terms: D000328:Adult; D064591:Allografts; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D017690:Cell Transplantation / Q000379:methods*; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D007011:Hypoparathyroidism / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium