title: CXCR5-mediated shaping of the lymphoid follicle in chronic lymphocytic leukemia.
abstract: Heinig and colleagues, using the Eμ-Tcl1 mouse model of chronic lymphocytic leukemia (CLL), shed light on the trafficking routes of CLL cells into the protective microenvironmental niches in secondary lymphoid organs. The authors propose a crucial role of the resident follicular dendritic cells for leukemia pathogenesis that is essentially orchestrated by the chemokine receptor CXCR5.
authors.affiliation: Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Hematopathology Unit, Department of Pathology, Hospital Clínic, Barcelona, Spain.
authors.forename: Mònica
authors.initials: M
authors.lastname: López-Guerra
authors.affiliation: Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Xargay-Torrent
authors.affiliation: Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Hematopathology Unit, Department of Pathology, Hospital Clínic, Barcelona, Spain. dcolomer@clinic.cat.
authors.forename: Dolors
authors.initials: D
authors.lastname: Colomer
mesh_terms: D000818:Animals; D020566:Dendritic Cells, Follicular / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*