title: Rutin mediated targeting of signaling machinery in cancer cells.
abstract: Progress in our understanding of molecular oncology has started to shed light on dysregulation of spatio-temporally controlled signaling pathways, inactivation of tumor suppressor genes, tumour and normal stem cell quiescence, overexpression of oncogenes, extracellular and stromal microenvironments, epigenetics and autophagy. Sequentially and characteristically it has been shown that cancer cells acquire the ability to escape from apoptotic cell death, proliferate uncontrollably, sustain angiogenesis and tactfully reconstitute intracellular pathways to avoid immune surveillance. We have attempted to provide a recent snapshot of most recent progress with emphasis on how rutin modulates wide ranging intracellular signaling cascades as evidenced by in-vitro and in-vivo research. It is worth describing that 'single-cell proteomics' analysis has further improved our understanding regarding intracellular signaling pathways frequently activated in cancer cells resistant to therapeutics and can provide biomarkers for cancer diagnosis and prognosis. Data obtained from preclinical studies will prove to be helpful for scientists to bridge basic and translational studies.
authors.affiliation: Faculty of Science, Department of Biology, Division of Botany, Istanbul University, Istanbul, 34460 Turkey.
authors.forename: Aliye Aras
authors.initials: AA
authors.lastname: Perk
authors.affiliation: Diagnostic Imaging and Radiation Therapy Department, Lviv National Medical University, Lviv, Ukraine.
authors.forename: Iryna
authors.initials: I
authors.lastname: Shatynska-Mytsyk
authors.affiliation: Faculty of Science, Department of Biology, Division of Botany, Istanbul University, Istanbul, 34460 Turkey.
authors.forename: Yusuf Can
authors.initials: YC
authors.lastname: Gerçek
authors.affiliation: Faculty of Science, Department of Biology, Division of Botany, Istanbul University, Istanbul, 34460 Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Boztaş
authors.affiliation: Faculty of Science, Department of Biology, Division of Botany, Istanbul University, Istanbul, 34460 Turkey.
authors.forename: Mevzule
authors.initials: M
authors.lastname: Yazgan
authors.affiliation: Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, 35 Km Ferozepur Road, Lahore, Pakistan.
authors.forename: Sundas
authors.initials: S
authors.lastname: Fayyaz
authors.affiliation: Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, 35 Km Ferozepur Road, Lahore, Pakistan.
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
keywords: Apoptosis; Cancer; Signaling