title: mRNA localization in the Drosophila germline.
abstract: Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This review will discuss the diverse roles of mRNA localization in the Drosophila germline, the cis-elements and cellular components regulating localization and the superimposition of translational regulatory mechanisms. Despite a history of discovery, there are still many fundamental questions regarding mRNA localization that remain unanswered. Take home messages, outstanding questions and future approaches that will likely lead to resolving these unknowns in the future are summarized at the end.
authors.affiliation: a Department of Zoology ; University of Cambridge ; Cambridge , UK.
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Weil
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics* / Q000302:isolation & purification; D012261:Ribonucleoproteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein
keywords: Drosophila germline; active transport; mRNA localization; ribonucleoprotein (RNP) complex