title: Association analysis between 8-oxoguanine DNA glycosylase genetic variants and endometrial cancer susceptibility in Chinese Han population.
abstract: OBJECTIVE
  Numerous epidemiologic studies demonstrate that 8-oxoguanine DNA glycosylase gene (hOGG1) is an important candidate gene for the development of endometrial cancer (EC). The objective of this study is to evaluate the potential association between hOGG1 genetic variants and the susceptibility to EC.
  
  
  METHODS
  In total, 218 EC patients and 243 cancer-free controls were recruited in this study.
  
  
  RESULTS
  Our data indicate that the hOGG1 c.269C > A and c.828A > G genetic variants are statistically associated with the increased susceptibility to EC (for c.269C > A, AA vs CC: odds ratio (OR) = 2.14, 95% confidence interval (CI), 1.21 to 3.78, P = 0.008; A vs C: OR = 1.43, 95% CI, 1.09 to 1.88, P = 0.010; for c.828A > G, GG vs AA: OR = 2.31, 95% CI, 1.24 to 4.30, P = 0.008; G vs A: OR = 1.35, 95% CI, 1.03 to 1.78, P = 0.032). The A allele and AA genotype of c.269C > A and G allele and GG genotype of c.828A > G genetic variants could contribute to the susceptibility to EC.
  
  
  CONCLUSIONS
  Taken together, our findings suggest that the hOGG1 c.269C > A and c.828A > G genetic variants are significantly associated with EC susceptibility in Chinese Han populations and might be used as molecular markers for assessing the risk of EC.
authors.affiliation: Department of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Huaiwu
authors.initials: H
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Lingling
authors.initials: L
authors.lastname: Xie
authors.forename: Miaofang
authors.initials: M
authors.lastname: Wu
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Lin
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C024829:8-hydroxyguanine; D006147:Guanine; D045647:DNA Glycosylases
keywords: cancer susceptibility; endometrial cancer; genetic variants; hOGG1 gene; molecular markers