title: The relevance of dengue virus genotypes surveillance at country level before vaccine approval.
abstract: Dengue is a major threat for public health in tropical and subtropical countries around the world. In the absence of a licensed vaccine and effective antiviral therapies, control measures have been based on education activities and vector elimination. Current efforts for developing a vaccine are both promising and troubling. At the advent of the introduction of a tetravalent dengue vaccine, molecular surveillance of the circulating genotypes in different geographical regions has gained considerable importance. A growing body of in vitro, preclinical, and clinical phase studies suggest that vaccine conferred protection in a geographical area could depends on the coincidence of the dengue virus genotypes included in the vaccine and those circulating. In this review we present the state-of-the-art in this field, highlighting the need of deeper knowledge on neutralizing immune response for making decisions about future vaccine approval and the potential need for different vaccine composition for regional administration.
authors.affiliation: a Grupo de Virología; Subdirección Red Nacional de Laboratorios ; Dirección de Redes en Salud Pública; Instituto Nacional de Salud ; Bogotá DC , Colombia.
authors.forename: José A
authors.initials: JA
authors.lastname: Usme-Ciro
authors.forename: Jairo A
authors.initials: JA
authors.lastname: Méndez
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Laiton
authors.forename: Andrés
authors.initials: A
authors.lastname: Páez
mesh_terms: D003715:Dengue / Q000517:prevention & control* / Q000821:virology*; D053059:Dengue Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017277:Drug Approval; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology
chemical_list: D053059:Dengue Vaccines
keywords: ADE, antibody-dependent enhancement; DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin; DENV, dengue viruses; E, envelope protein; Hsp70, heat shock protein 70; Hsp90, heat shock protein 90; M, membrane protein; MRCA, more recent common ancestor; NS1, non-structural protein 1; UTR, untranslated region; dengue virus; genotypes; neutralizing antibodies; ssRNA+, single-stranded positive-sense RNA viruses; surveillance; vaccines