title: SERUM magnesium levels as an indicator of status of Diabetes Mellitus type 2.
abstract: BACKGROUND
  Magnesium deficiency is commonly associated with endocrine and metabolic disorders, especially with Diabetes Mellitus type 2 though the mechanism of hypomagnesemia in Diabetes Mellitus is not completely known. There is a close association between metabolic control of Diabetes Mellitus and impaired magnesium balance.
  
  
  OBJECTIVE
  To estimate the serum levels of magnesium in patients of with Diabetes Mellitus type 2 and to find a correlation if any, with the duration and control (by estimating HbA1c) of Diabetes Mellitus type 2.
  
  
  METHODS
  Fifty patients of Diabetes Mellitus type 2 were included in the study. Blood samples were analyzed for fasting and post prandial glucose, HbA1c and magnesium. The patients were grouped into three categories based upon their HbA1c levels into those with good control, need intervention and poor control. The three groups were compared with reference to their mean levels of blood glucose and magnesium. Association of serum magnesium levels with HbA1c, Fasting and postprandial blood glucose and duration of Diabetes Mellitus was also done.
  
  
  RESULTS
  Serum magnesium levels were found to decline with rise in HbA1c levels and with duration of Diabetes Mellitus type 2.
  
  
  CONCLUSIONS
  Hypomagnesemia is linked to poor control of Diabetes Mellitus type 2 and depletion of serum magnesium occurs exponentially with duration of disease.
authors.affiliation: Department of Physiology, Indira Gandhi Medical College and Research Institute, Pondicherry, India. Electronic address: ramarguz@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Ramadass
authors.affiliation: Department of Biochemistry, Indira Gandhi Medical College and Research Institute, Pondicherry, India. Electronic address: ddbasu@gmail.com.
authors.forename: Sharbari
authors.initials: S
authors.lastname: Basu
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India. Electronic address: raghavan.drvars2000@gmail.com.
authors.forename: A R
authors.initials: AR
authors.lastname: Srinivasan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007194:India / Q000453:epidemiology; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008274:Magnesium; C517652:hemoglobin A1c protein, human
keywords: Diabetes Mellitus type 2; HbA1c; Hypomagnesemia