title: Wound repair and regeneration: mechanisms, signaling, and translation.
abstract: The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
authors.affiliation: Department of Dermatology, University of Cologne, Cologne 50937, Germany. Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany. Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne 50931, Germany. sabine.eming@uni-koeln.de paul.martin@bristol.ac.uk mtcanic@med.miami.edu.
authors.forename: Sabine A
authors.initials: SA
authors.lastname: Eming
authors.affiliation: Schools of Biochemistry and Physiology and Pharmacology, Faculty of Medical and Veterinary Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK. School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. sabine.eming@uni-koeln.de paul.martin@bristol.ac.uk mtcanic@med.miami.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Martin
authors.affiliation: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. sabine.eming@uni-koeln.de paul.martin@bristol.ac.uk mtcanic@med.miami.edu.
authors.forename: Marjana
authors.initials: M
authors.lastname: Tomic-Canic
mesh_terms: D000375:Aging; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002921:Cicatrix; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007239:Infections; D007249:Inflammation; D051379:Mice; D009389:Neovascularization, Pathologic; D010447:Peptide Hydrolases / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction; D012867:Skin / Q000473:pathology; D013234:Stem Cells / Q000166:cytology; D057170:Translational Research, Biomedical; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D010447:Peptide Hydrolases