title: Long-Term Efficacy of Oxybutynin for Palmar and Plantar Hyperhidrosis in Children Younger than 14 Years.
abstract: Oxybutynin for treating hyperhidrosis in children has been evaluated only in short-term studies. We aimed to investigate the long-term effects of oxybutynin in treating children with palmar and plantar hyperhidrosis who had not undergone surgery and who were monitored for at least 6 months (median 19.6 mos). A cohort of 97 patients was evaluated retrospectively, with particular attention to 59 children (ages 4-14 yrs) who were treated for longer than 6 months. Their quality of life (QOL) was evaluated using a validated clinical questionnaire before and after 6 weeks of pharmacologic therapy. A self-assessment of hyperhidrosis was performed after 6 weeks and after the last consultation. By their final office visit, more than 91% of the children with hyperhidrosis treated with oxybutynin experienced moderate or great improvement in their level of sweating and 94.9% experienced improvement in QOL. More than 90% of children reported improvement of hyperhidrosis at other sites. Dry mouth was the most common side effect. Oxybutynin appears to be an effective treatment option for children with hyperhidrosis, and positive results are maintained over the long term (median 19.6 mos).
authors.affiliation: Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.|Vascular and Endovascular Division, Department of Surgery, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Wolosker
authors.affiliation: Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Marcelo P
authors.identifier: http://orcid.org/0000-0002-3648-6773
authors.initials: MP
authors.lastname: Teivelis
authors.affiliation: Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Krutman
authors.affiliation: Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Rafael P
authors.initials: RP
authors.lastname: de Paula
authors.affiliation: Division of Pediatrics, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Claudio
authors.initials: C
authors.lastname: Schvartsman
authors.affiliation: Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Kauffman
authors.affiliation: Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.|Division of Thoracic Surgery, Hospital das Clinicas, University of São Paulo and Division of Thoracic Surgery, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: José R M
authors.initials: JR
authors.lastname: de Campos
authors.affiliation: Vascular and Endovascular Division, Department of Surgery, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Puech-Leão
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005528:Foot; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000627:therapeutic use*; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin