title: [Temporary recommendation for use on off-label baclofen: viewpoint of Prescribers of the CAMTEA system].
abstract: The use of high dose baclofen for alcohol-dependence emerged in France from 2008 based on empirical findings, and is still off-label. However, due to the rapid increase in this prescribing practice, the French health authorities have decided to frame it using an extraordinary regulatory measure named "temporary recommendation for use" (TRU). Baclofen prescribers from CAMTEA, a regional team-based off-label system for supervising baclofen prescribing, which was developed much prior to the TRU, discuss herein the pros and cons of this measure and the applicability of its different aspects in the daily clinical practice.
authors.affiliation: Université Lille Nord de France, Lille, France - Service d'addictologie, Hôpital Fontan 2, CHRU de Lille, Lille, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rolland
authors.affiliation: Centre d'évaluation et d'information sur la pharmacodépendance, CHRU de Lille, Lille, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Deheul
authors.affiliation: Université Lille Nord de France, Lille, France - CSAPA, CHRU-Le Pari, CHRU de Lille, Lille, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Danel
authors.affiliation: Service d'addictologie, Hôpital Fontan 2, CHRU de Lille, Lille, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Bence
authors.affiliation: CSAPA, le Cèdre Bleu, Lomme, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Blanquart
authors.affiliation: Service d'addictologie, Pôle de psychiatrie, Centre hospitalier de Valenciennes, Valenciennes, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bonord
authors.affiliation: Service d'addictologie, Pôle de psychiatrie, Centre hospitalier de Valenciennes, Valenciennes, France.
authors.forename: Robin
authors.initials: R
authors.lastname: Semal
authors.affiliation: CSAPA, Centre Horizon de l'Aisne, Saint Quentin, France - Service d'addictologie, CH de Ham, Ham, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Briand
authors.affiliation: Service d'addictologie, CH de Ham, Ham, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Sochala
authors.affiliation: CSAPA le Square, Lens, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Dubocage
authors.affiliation: Service de psychiatrie et d'addictologie, Secteur 62G05, CHAM, Rang du Fliers, France.
authors.forename: François
authors.initials: F
authors.lastname: Dupriez
authors.affiliation: Service d'addictologie, CSAPA, CH d'Arras, Arras, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Duquesne
authors.affiliation: Service d'addictologie, CH de Saint-Amand-les-Eaux, Saint-Amand-les-Eaux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Gibour
authors.affiliation: Service d'addictologie, CH de Saint-Amand-les-Eaux, Saint-Amand-les-Eaux, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Loosfeld
authors.affiliation: Service de psychiatr CH de Tourcoing, Tourcoing, France.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Henebelle
authors.affiliation: Service de psychiatr CH de Tourcoing, Tourcoing, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Henon
authors.affiliation: Service d'addictologie, CH de Boulogne-sur-Mer, Boulogne-sur-Mer, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Vernalde
authors.affiliation: Service d'addictologie, Clinique de la Mitterie, Lomme, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Matton
authors.affiliation: Service d'addictologie, Clinique de la Mitterie, Lomme, France.
authors.forename: Jean-Eudes
authors.initials: JE
authors.lastname: Bacquet
authors.affiliation: Service d'addictologie, CH de Hazebrouck, Hazebrouck, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Molmy
authors.affiliation: Service d'addictologie, CH Région de Saint Omer, Helfaut, France.
authors.forename: François
authors.initials: F
authors.lastname: Sarasy
authors.affiliation: CSAPA du Jeu de Paume, EPSM Val de Lys-Artois, Béthune, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Simioni
authors.affiliation: Service d'addictologie, UFAL-CSAPA, CH de Dunkerque, Dunkerque, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Richez
authors.affiliation: Service d'addictologie, CH de Tourcoing, Tourcoing, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Gentil-Spinosi
authors.affiliation: Service d'addictologie, CH Sambre Avesnois, Maubeuge, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Vosgien
authors.affiliation: Pôle d'addictologie, CH d'Avesnes-sur-Helpe, Avesnes-sur-Helpe, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Yguel
authors.affiliation: Service d'addictologie, CH de Carvin, Carvin, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Ledent
authors.affiliation: Centre régional de pharmacovigilance, CHRU de Lille, Lille, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Auffret
authors.affiliation: CH Abbeville, Abbeville, France.
authors.forename: Maroussia
authors.initials: M
authors.lastname: Wilquin
authors.affiliation: Unité d'alcoologie clinique les Erables, CH Hénin Beaumont, Hénin Beaumont, France.
authors.forename: Danièle
authors.initials: D
authors.lastname: Ziolkowski
authors.affiliation: Médecine générale, Ham, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Sochala
authors.affiliation: Université Lille Nord de France, Lille, France - Centre régional de pharmacovigilance, CHRU de Lille, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gautier
authors.affiliation: Université Lille Nord de France, Lille, France - Centre d'évaluation et d'information sur la pharmacodépendance, CHRU de Lille, Lille, France - Centre régional de pharmacovigilance, CHRU de Lille, Lille, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Bordet
authors.affiliation: Université Lille Nord de France, Lille, France - Service d'addictologie, Hôpital Fontan 2, CHRU de Lille, Lille, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cottencin
mesh_terms: D000437:Alcoholism / Q000188:drug therapy*; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005602:France; D006801:Humans; D056687:Off-Label Use; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*
chemical_list: D001418:Baclofen