title: Galenic approaches in troubleshooting of glibenclamide tablet adhesion in compression machine punches.
abstract: This study aimed to examine the adhesion of glibenclamide 5 mg tablets to the tools of compression machines. This problem is not commonly reported in the literature, since it is considered as tacit knowledge. The starting point was the implementation of three technical alternatives: changing the parameters of compression, evaluating the humidity of the powder blend and the manufacturer of the lubricant magnesium stearate. The adhesion was directly related to the characteristics of magnesium stearate from different manufacturers, and the feasibility of evaluating powder flow characteristics by different techniques that are not routinely followed in various pharmaceutical companies. In vitro dissolution tests showed that the magnesium stearate manufacturer can influence on the dissolution profile of glibenclamide tablets. This study presented various aspects of tablet adhesion to compression machine punches. Troubleshooting approaches can be, most of times, conducted based on previous experience, or an experimental research needs to be implemented in order to have confident results.
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Janine
authors.initials: J
authors.lastname: Boniatti
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: Pereira Cerqueira
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Alexandre Carnevale
authors.initials: AC
authors.lastname: de Souza
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Cristiane Rodrigues
authors.initials: CR
authors.lastname: Drago Hoffmeister
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Maira Assis
authors.initials: MA
authors.lastname: da Costa
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Livia Deris
authors.initials: LD
authors.lastname: Prado
authors.affiliation: University of Caxias do Sul, R. Francisco Getúlio Vargas 1130, 95070-560 Caxias do Sul, RS, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Tasso
authors.affiliation: Farmanguinhos (FIOCRUZ), Av. Comandante Guaranys 447, 22775-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Helvécio Vinícius
authors.initials: HV
authors.lastname: Antunes Rocha
keywords: Adhesion; Glibenclamide; Magnesium stearate; Tableting