title: A prospective follow-up study of the relationship between C-reactive protein and human cancer risk in the Chinese Kailuan Female Cohort.
abstract: BACKGROUND
  C-reactive protein (CRP) has been associated with cancer risk in some prospective studies. However, the associations have not been entirely consistent and have not been evaluated in Chinese females. We conducted a large population-based cohort study to investigate whether elevated levels of CRP at baseline are associated with an increased risk of cancer among Chinese females.
  
  
  METHODS
  A total of 19,437 women from the Chinese Kailuan Female Cohort were enrolled in the study in July 2006. Levels of high-sensitivity CRP (hsCRP) were tested at baseline for all subjects. Multivariable Cox proportional hazards regression models were used to evaluate the association between levels of hsCRP and risk of all cancers, including breast cancer, lung cancer, colorectal cancer, and other cancers.
  
  
  RESULTS
  By December 31, 2011, a total of 322 incident cancer cases accrued. Compared with women with lower hsCRP levels (<1 mg/L), women with higher hsCRP (>3 mg/L) had a significantly increased risk of all incident cancers [HR, 1.62; 95% confidence intervals (CI), 1.23-2.14; P(trend) = 0.001] and breast cancer (HR, 1.74; 95% CI, 1.01-2.97; P(trend) = 0.047). The significant association between hsCRP levels and breast cancer risk was apparent among younger women (<50 years; HR, 2.76; 95% CI, 1.18-6.48).
  
  
  CONCLUSIONS
  Elevated levels of hsCRP at baseline may be associated with an increased risk of cancer, especially breast cancer, and particularly in younger Chinese women.
  
  
  CONCLUSIONS
  Our findings provide additional evidence for a role of inflammation in carcinogenesis and suggest that CRP may be a potentially useful biomarker of cancer risk in this population.
authors.affiliation: Department of Oncology, Kailuan General Hospital, Tangshan, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Li
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chang
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Bassig
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Lanwei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Jiansong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Su
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Health Department of Kailuan (group), Tangshan, China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Health Department of Kailuan (group), Tangshan, China.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Oncology, Kailuan General Hospital, Tangshan, China.
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut. tongzhang.zheng@yale.edu prof.hejie@263.net.
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China. tongzhang.zheng@yale.edu prof.hejie@263.net.
authors.forename: Jie
authors.initials: J
authors.lastname: He
mesh_terms: D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology*; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein