title: Correlation of gleason scores with magnetic resonance diffusion tensor imaging in peripheral zone prostate cancer.
abstract: BACKGROUND
  To investigate tumor aggressiveness in peripheral zone prostate cancer (PCa) by correlating Gleason score (GS) with diffusion tensor imaging (DTI) from multiparametric magnetic resonance imaging (MRI) at 3.0 Tesla (T).
  
  
  METHODS
  Eighty-three patients with pathological proven peripheral zone PCa whose GS in at least one core biopsy met the criteria(GS ≤3+3, GS 3+4, GS 4+3, or GS ≥4+4) were included in this study. DTI was performed using b values of 0 and 800 s/mm(2) with 32 directions in all patients on a 3.0T MRI scanner. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were calculated from the DTI data of patients with the previously mentioned four categories of Gleason scores. An association between DTI measurements(FA, ADC) and GS was tested using the Spearman rank correlation analysis.
  
  
  RESULTS
  FA values in the sextants found to harbor cancer were positively correlated with the GS(r = 0.48; P < 0.001), while the ADC values were negatively correlated with GS(r = -0.54; P < 0.001). Statistical significance(P < 0.05) was found for FA values among different GS groups, with the exception of GS 3+4 versus GS 4+3 (P = 0.105). The differences between the ADC values were statistically significant for all four different scores(all P < 0.05).
  
  
  CONCLUSIONS
  Quantitative DTI at 3.0T MRI shows a significant association with GS in the evaluation of tumor aggressiveness in peripheral zone PCa, which may be useful to ensure concordance of biopsy results and therefore make the appropriate decision in the management of patients with PCa.
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Radiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
authors.forename: Daniel J A
authors.initials: DJ
authors.lastname: Margolis
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.affiliation: Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiangde
authors.initials: X
authors.lastname: Min
authors.affiliation: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Daoyu
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D010363:Pattern Recognition, Automated / Q000379:methods*; D011467:Prostate / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
keywords: diffusion tensor imaging; prostate cancer; quantitative analysis; tumor aggressiveness