title: Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L.) infantum chagasi-infection.
abstract: American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection--AI, Sub-clinical Resistant Infection--SRI, and Indeterminate Initial Infection--III), and two symptomatic ones [Symptomatic Infection--SI (=AVL) and Sub-clinical Oligosymptomatic Infection--SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.
authors.forename: Luciana Vieira
authors.initials: LV
authors.lastname: do Rêgo Lima
authors.forename: Patrícia Karla
authors.initials: PK
authors.lastname: Santos Ramos
authors.forename: Marliane Batista
authors.initials: MB
authors.lastname: Campos
authors.forename: Thiago Vasconcelos
authors.initials: TV
authors.lastname: dos Santos
authors.forename: Claudia Maria
authors.initials: CM
authors.lastname: de Castro Gomes
authors.forename: Márcia Dalastra
authors.initials: MD
authors.lastname: Laurenti
authors.forename: Carlos Eduardo Pereira
authors.initials: CE
authors.lastname: Corbett
authors.forename: Fernando Tobias
authors.initials: FT
authors.lastname: Silveira
mesh_terms: D000913:Antibodies, Protozoan / Q000097:blood*; D058345:Asymptomatic Infections; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D018314:Leishmania infantum / Q000276:immunology* / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014481:United States; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D007075:Immunoglobulin M
keywords: American visceral leishmaniasis; Human indeterminate initial infection,; IgM-antibody response,; Leishmania (L.) infantum chagasi,; Preclinical diagnosis,