title: FTO: linking m6A demethylation to adipogenesis.
abstract: Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.
authors.affiliation: 1] Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel [2] Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.
authors.forename: Moshe Shay
authors.initials: MS
authors.lastname: Ben-Haim
authors.affiliation: Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Moshitch-Moshkovitz
authors.affiliation: 1] Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel [2] Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.
authors.forename: Gideon
authors.initials: G
authors.lastname: Rechavi
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives*; D017667:Adipocytes / Q000166:cytology*; D050156:Adipogenesis; D000818:Animals; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D006899:Mixed Function Oxygenases; D007652:Oxo-Acid-Lyases; D000241:Adenosine