title: Synthesis of unsymmetrical 3,6-branched Man5 oligosaccharide: a comparison between one-pot sequential glycosylation and stepwise synthesis.
abstract: An expeditious three-component, one-pot sequential glycosylation protocol has been developed for the preparation of 3,6-branched unsymmetrical mannopentaose (Man5), employing a mannose trisaccharide donor, a mannose monosaccharide donor and a mannose monosaccharide acceptor. The high efficiency of this one-pot procedure was demonstrated by comparison study with a stepwise synthesis using the same three building blocks.
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Chen
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Jin
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
authors.forename: Haining
authors.initials: H
authors.lastname: Tan
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Jinan 250012, China. Electronic address: fswang@sdu.edu.cn.
authors.forename: Fengshan
authors.initials: F
authors.lastname: Wang
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China. Electronic address: hzcao@sdu.edu.cn.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Cao
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006031:Glycosylation; D008358:Mannose / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D014312:Trisaccharides / Q000737:chemistry
chemical_list: D009844:Oligosaccharides; D014312:Trisaccharides; C048068:mannopentaose; D008358:Mannose
keywords: Glycosylation; Oligomannose; One-pot; Thioglycoside