title: Feasibility, Sensitivity, and Specificity of Postprocedure Peritoneal Cytology.
abstract: The objective of this study was to determine the feasibility and diagnostic performance of cytopathologic evaluation of postprocedure washings collected after hysterectomy for gynecologic cancer. A total of 92 cases of hysterectomy for malignancy having cytology reports of both pre- and postprocedure washings were retrospectively identified. In all, 98.7% of preprocedure and 99.3% of postprocedure washings (P = 1.00) were satisfactory for cytopathology. Discordance regarding the observation of malignant cells between preprocedure and postprocedure washings was insignificant (P = .267). The sensitivity of postprocedure cytology for detecting malignant cells in cases of positive peritoneal histology was significantly lower than the sensitivity of preprocedure cytology (28.6% vs 57.1%, P = .041), with similar specificities (both 94%). Four patients with endometrial cancer having negative preprocedure peritoneal cytology were discovered to have positive postprocedure cytology. Postprocedure peritoneal cytology is feasible and may benefit patients with early-stage cancer by increasing the detection of microscopic peritoneal metastasis or cancer cell seeding during surgery.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Western Connecticut Health Network, Danbury, CT, USA.
authors.forename: Brandon-Luke L
authors.initials: BL
authors.lastname: Seagle
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Western Connecticut Health Network, Danbury, CT, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Dawson
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Western Connecticut Health Network, Danbury, CT, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Samuelson
authors.affiliation: Department of Pathology and Laboratory Medicine, Western Connecticut Health Network, Danbury, CT, USA.
authors.forename: Mary S
authors.initials: MS
authors.lastname: Chacho
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Rutherford
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Western Connecticut Health Network, Danbury, CT, USA shohreh.shahabi@wchn.org.
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahabi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003581:Cytodiagnosis / Q000379:methods / Q000592:standards*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000639:trends; D008875:Middle Aged; D010537:Peritoneum / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies
keywords: cancer; cytology; postoperative