title: Tumor volume: an adjunct prognostic factor in cutaneous melanoma.
abstract: Measurement of tumor volume may be a helpful adjunct to established prognostic factors in cutaneous melanoma, including Breslow depth, presence or absence of ulceration, mitotic index, lymphovascular invasion, and microsatellites. This report expands on the theory that a tumor volume cutoff point of 250 mm³ as measured by surface area of the lesion (ie, longest vertical and horizontal measurements either based on clinical or gross pathological assessment) multiplied by the Breslow depth could serve as a potentially relevant predictor of sentinel lymph node (SLN) metastasis in both thin and thick invasive cutaneous melanomas, which prompted investigation of a larger sample size using the pathology database at our institution.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Walton
authors.forename: Jinah
authors.initials: J
authors.lastname: Kim
authors.forename: Cruz
authors.initials: C
authors.lastname: Velasco
authors.affiliation: Department of Dermatology/Cutaneous Oncology, Stanford University Medical Center and Cancer Institute, 900 Blake Wilbur Dr, W3045, Stanford, CA 94305-5356, USA. sswetter@stanford.edu.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Swetter
mesh_terms: D057186:Comparative Effectiveness Research; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology; D047368:Tumor Burden; D000096142:Cutaneous Malignant Melanoma