title: An update on primary findings and new designs in biotherapy studies for acute myocardial infarction.
abstract: Treatment of acute myocardial infarction in the future should focus not only on improving acute treatment, as it has been done over the past decades, but also on secondary prevention of left ventricular dysfunction and/or progression to heart failure by preserving left ventricular shape, avoiding left ventricular remodeling and stimulating cardiac regeneration. Biotherapies with adult stem cells and bone marrow-derived endothelial cell progenitors, combined or not with biomaterials, and new drugs are under investigation and will probably be part of routine clinical practice for patients suffering from myocardial infarction in the near future.
authors.forename: Jerome
authors.initials: J
authors.lastname: Roncalli
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy*; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000517:prevention & control*; D020257:Ventricular Remodeling
keywords: CD34+ cells; alginates; biomaterials; cardiac regeneration; cardioprotection; left ventricular remodeling; mesenchymal stromal cells; mononucleated cells