title: Chromosomal aberrations and polymorphic evaluation in males with primary infertility from Indian population.
abstract: OBJECTIVE
  The chromosomal abnormalities are one of the important causes of male infertility. In view of the genetic risks for the next generation, the importance of careful evaluation of karyotype is essential. The objective of this study was to determine the frequency of chromosomal abnormalities in infertile men with primary infertility from Indian population.
  
  
  METHODS
  The 78 infertile men with primary infertility, out of which 26 men were azoospermic, 19 men were oligospermic, 4 men were asthenospermic and 29 men were oligoasthenospermic were studied. Karyoptying was performed on peripheral blood lymphocytes by using the Giemsa trypsin banding (GTG) banding technique. Additional data was collected from published studies in Indian population leading to a total of 1814 cases.
  
  
  RESULTS
  Chromosome analysis of 78 infertile males showed major chromosome abnormalities in 10.2%, with 6.4% in autosomal chromosome abnormalities and 3.8% in sex chromosome abnormalities. The incidence of major chromosome abnormalities in oligospermic males were 21% and azoospermic males were 15.4 %. Chromosomal polymorphic variants were identified to be 16.7%. Combining the data from other published studies identified 153/ 1814 (8.4%) infertile men of chromosomal abnormalities; with 10.8% in azoospermia, 7.3% in oligospermia and 7.3% in oligoasthenoteratospermic from India.
  
  
  CONCLUSIONS
  The overall high prevalence of chromosomal abnormalities in infertile males suggests that the conventional chromosomal analysis is an important investigative tool for male infertility, especially prior to use of any assisted reproductive techniques.
authors.affiliation: Senior Scientific Officer & Quality Manager, Department of Cytogenetics, PreventiNe Life Care Pvt Ltd. , Mumbai, India .
authors.forename: Ushang V
authors.initials: UV
authors.lastname: Kate
authors.affiliation: Scientific Officer, Department of Cytogenetics, PreventiNe Life Care Pvt Ltd. , Mumbai, India .
authors.forename: Yamini S
authors.initials: YS
authors.lastname: Pokale
authors.affiliation: Scientific Officer, Department of Cytogenetics, PreventiNe Life Care Pvt Ltd. , Mumbai, India .
authors.forename: Ajinkya M
authors.initials: AM
authors.lastname: Jadhav
authors.affiliation: Head of Department, Genetic Division, Department of Anatomy, Grant Medical College & Sir J.J. Group of Hospitals , Mumbai, India .
authors.forename: Suresh D
authors.initials: SD
authors.lastname: Gangane
keywords: Chromosomal abnormality; Cytogenetic study; Heteromorphism; Male infertility