title: Current perspectives on reflux laryngitis.
abstract: Laryngopharyngeal reflux (LPR) is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). With the increase of GERD patients, the importance of LPR is acknowledged widely. However, the pathophysiology of LPR is not understood completely and the diagnostic criteria for LPR remain controversial. Unfortunately, a gold standard diagnostic test for reflux laryngitis is not available. Recently, an experimental animal model for reflux laryngitis was developed to investigate the pathophysiology of reflux laryngitis. An empirical trial of lifestyle modification and proton pump inhibitor therapy is a reasonable approach for LPR symptoms. Alternatives after failure with aggressive medical treatment are limited and multichannel intraluminal impedance and pH monitoring is currently the best alternative to detect nonacid reflux. Additional prospective and evidence-based research is anticipated.
authors.affiliation: Department of Gastroenterology, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan, daisuke@juntendo.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Asaoka
authors.forename: Akihito
authors.initials: A
authors.lastname: Nagahara
authors.forename: Kenshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Mariko
authors.initials: M
authors.lastname: Hojo
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D050782:Esophageal pH Monitoring; D018662:Fundoplication; D015438:Health Behavior; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007828:Laryngoscopy; D008019:Life Style; D008297:Male; D010434:Pepsin A / Q000032:analysis; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors; D010434:Pepsin A