title: The discovery and development of a novel vaccine to protect against Neisseria meningitidis Serogroup B Disease.
abstract: Vaccines have had a major impact on the reduction of many diseases globally. Vaccines targeted against invasive meningococcal disease (IMD) due to serogroups A, C, W, and Y are used to prevent these diseases. Until recently no vaccine had been identified that could confer broad protection against Neisseria meningitidis serogroup B (MnB). MnB causes IMD in the very young, adolescents and young adults and thus represents a significant unmet medical need. In this brief review, we describe the discovery and development of a vaccine that has the potential for broad protection against this devastating disease.
authors.affiliation: a Pfizer Vaccine Research; Pearl River, NY USA.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Zlotnick
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Jones
authors.forename: Paul
authors.initials: P
authors.lastname: Liberator
authors.forename: Li
authors.initials: L
authors.lastname: Hao
authors.forename: Shannon
authors.initials: S
authors.lastname: Harris
authors.forename: Lisa K
authors.initials: LK
authors.lastname: McNeil
authors.forename: Duzhang
authors.initials: D
authors.lastname: Zhu
authors.forename: John
authors.initials: J
authors.lastname: Perez
authors.forename: Joseph
authors.initials: J
authors.lastname: Eiden
authors.forename: Kathrin U
authors.initials: KU
authors.lastname: Jansen
authors.forename: Annaliesa S
authors.initials: AS
authors.lastname: Anderson
mesh_terms: D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D009345:Neisseria meningitidis; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*
chemical_list: D022401:Meningococcal Vaccines
keywords: Neisseria meningitidis; Serogroup B; factor H binding protein; serum bactericidal assay with human complement (hSBA); vaccine