title: Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids.
abstract: A previously healthy 48-year-old woman was evaluated for lightheadedness and chest heaviness 2 weeks after starting the herbal supplement Garcinia cambogia. She was found to be hypotensive and had an elevated serum troponin level. The patient had a progressive clinical decline, ultimately experiencing fulminant heart failure and sustained ventricular arrhythmias, which required extracorporeal membrane oxygenation support. Endomyocardial biopsy results were consistent with acute necrotizing eosinophilic myocarditis (ANEM). High-dose corticosteroids were initiated promptly and her condition rapidly improved, with almost complete cardiac recovery 1 week later. In conclusion, we have described a case of ANEM associated with the use of Garcinia cambogia extract.
authors.affiliation: Department of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA. Electronic address: scal@med.umich.edu.
authors.forename: Scott F
authors.initials: SF
authors.lastname: Allen
authors.affiliation: Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Godley
authors.affiliation: Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Evron
authors.affiliation: Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Amer
authors.initials: A
authors.lastname: Heider
authors.affiliation: Department of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Nicklas
authors.affiliation: Department of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Thomas
mesh_terms: D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D029761:Garcinia cambogia / Q000009:adverse effects*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D009205:Myocarditis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D009206:Myocardium / Q000473:pathology; D028321:Plant Preparations / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D028321:Plant Preparations