title: Advances in the evaluation and management of esophageal disease of systemic sclerosis.
abstract: Symptoms of heartburn and dysphagia as well as objective findings of abnormal esophageal acid exposure and esophageal dysmotility are common in patients with systemic sclerosis (SSc). Treatments for SSc esophageal disease are generally limited to gastroesophageal reflux disease (GERD) treatment with proton pump inhibitors. Progresses made in esophageal diagnostic testing offer the potential for improved clinical characterization of esophageal disease in SSc that may help direct management decisions. In addition to reviewing GERD management in patients with SSc, present and potential uses of endoscopy, reflux monitoring, manometry, impedance planimetry, and endoscopic ultrasound are discussed.
authors.affiliation: Feinberg School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Northwestern University, 676 St Clair St, Suite 1400, Chicago, IL, 60611-2951, USA, dustin-carlson@northwestern.edu.
authors.forename: Dustin A
authors.initials: DA
authors.lastname: Carlson
authors.forename: Monique
authors.initials: M
authors.lastname: Hinchcliff
authors.forename: John E
authors.initials: JE
authors.lastname: Pandolfino
mesh_terms: D016099:Endoscopy, Gastrointestinal / Q000379:methods; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000628:therapy; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D008365:Manometry / Q000379:methods; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D054328:Proton Pump Inhibitors