title: Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population.
abstract: Certain gene polymorphisms are associated with human aging. This study investigated polymorphisms of a metabolism-related gene, Klotho, and an inflammatory gene, IL6, for association with the aging process in a healthy Han Chinese population. A total of 482 healthy subjects were recruited and divided into aging and young groups according to chronological age and biological age. Snapshots were used to detect a Klotho gene tag SNP (rs571118) and the F-SNPs rs9536314 (F352V) and rs9527025 (C370S), and an interleukin 6 (IL-6) gene tag SNP (rs1524107) and the F-SNPs rs1800795 (-174G/C) and rs1800796 (-572G/C). Klotho F352V and IL-6-174G/C was G homozygous, C370S was T homozygous while IL-6-572G/C MAF less than 5%. There was a statistically significant difference in the Klotho rs571118 SNP between chronological age groups, but not biological age groups. However, other SNPs, including IL-6 gene SNPs, didn't correlate with age in the Han Chinese population. Human aging is a complex process that includes chronological and biological aging. Our current data showed that Klotho gene rs571118 SNP was associated with chronological aging, but not biological aging, in a Han Chinese population. Further study will investigate genetic build up for the difference between chronological and biological aging.
authors.affiliation: Xiang-Mei Chen, Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing 100853, China. Phone: 86-010-66937463; Fax: 86-010-68130297; Email: xmchen301@126.com.
authors.forename: W-G
authors.initials: WG
authors.lastname: Zhang
authors.forename: X-J
authors.initials: XJ
authors.lastname: Bai
authors.forename: D-P
authors.initials: DP
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Lv
authors.forename: X-F
authors.initials: XF
authors.lastname: Sun
authors.forename: G-Y
authors.initials: GY
authors.lastname: Cai
authors.forename: X-Y
authors.initials: XY
authors.lastname: Bai
authors.forename: X-M
authors.initials: XM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D005966:Glucuronidase; D000090265:Klotho Proteins