title: Light emitting fabric technologies for photodynamic therapy.
abstract: Photodynamic therapy (PDT) is considered to be a promising method for treating various types of cancer. A homogeneous and reproducible illumination during clinical PDT plays a determinant role in preventing under- or over-treatment. The development of flexible light sources would considerably improve the homogeneity of light delivery. The integration of optical fiber into flexible structures could offer an interesting alternative. This paper aims to describe different methods proposed to develop Side Emitting Optical Fibers (SEOF), and how these SEOF can be integrated in a flexible structure to improve light illumination of the skin during PDT. Four main techniques can be described: (i) light blanket integrating side-glowing optical fibers, (ii) light emitting panel composed of SEOF obtained by micro-perforations of the cladding, (iii) embroidery-based light emitting fabric, and (iv) woven-based light emitting fabric. Woven-based light emitting fabrics give the best performances: higher fluence rate, best homogeneity of light delivery, good flexibility.
authors.affiliation: INSERM U 703, Lille University Hospital-CHRU, 152, rue du Dr. Yersin, 59120 Loos, France; University of Lille, F-59000 Lille, France. Electronic address: serge.mordon@inserm.fr.
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
authors.affiliation: ENSAIT, GEMTEX, F-59100 Roubaix, France; University of Lille, F-59000 Lille, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Cochrane
authors.affiliation: INSERM U 703, Lille University Hospital-CHRU, 152, rue du Dr. Yersin, 59120 Loos, France.
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Tylcz
authors.affiliation: INSERM U 703, Lille University Hospital-CHRU, 152, rue du Dr. Yersin, 59120 Loos, France; University of Lille, F-59000 Lille, France.
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.affiliation: INSERM U 703, Lille University Hospital-CHRU, 152, rue du Dr. Yersin, 59120 Loos, France; University of Lille, F-59000 Lille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mortier
authors.affiliation: ENSAIT, GEMTEX, F-59100 Roubaix, France; University of Lille, F-59000 Lille, France.
authors.forename: Vladan
authors.initials: V
authors.lastname: Koncar
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D008029:Lighting / Q000295:instrumentation*; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012666:Semiconductors; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents
keywords: Embroidery; Light emitting fabric; Micro-perforation; Optical fiber; Photodynamic therapy; Weaving