title: Meeting report VLPNPV: Session 8: Vaccines I.
abstract: In Session 8 of the recent conference "Virus-Like Particle and Nano-Particle Vaccines" held at the Salk Institute in La Jolla, California (05 June 2014), four scientists described new virus-like particle (VLP) approaches, progress, and early-stage plans for vaccines against significant human pathogens including HPV, malaria, HIV, Dengue, and RSV. A unifying theme was that displaying epitopes in an array on a virus-like particle can be a powerful approach for achieving a strong immune response. VLP approaches described included display of epitopes on bacteriophage, display of epitopes as fusions with other protein multimerization domains, and self-assembly of recombinantly-expressed virus coat proteins. Another theme in some of the presentations was the targeting of neutralizing epitopes that are masked or only transiently accessible during natural infection.
authors.affiliation: a Associate Principal Scientist - Biologics and Vaccine Formulation; Vaccine Drug Product Development; Merck Research Laboratories ; West Point , PA USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Thiriot
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D001435:Bacteriophages / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology*; D053059:Dengue Vaccines / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology; D053758:Nanoparticles; D053918:Papillomavirus Vaccines / Q000276:immunology; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology; D058425:Vaccines, Virus-Like Particle / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D016915:AIDS Vaccines; D036022:Capsid Proteins; D053059:Dengue Vaccines; D000939:Epitopes; D017780:Malaria Vaccines; D053918:Papillomavirus Vaccines; D011993:Recombinant Fusion Proteins; D022261:Respiratory Syncytial Virus Vaccines; D058425:Vaccines, Virus-Like Particle
keywords: Bacteriophage display; E2 display; HIV (human immunodeficiency virus); HPV (human papillomavirus); RSV (respiratory syncytial virus); VLP (virus-like particle); dengue; malaria; vaccine development