title: Weight loss and metabolic outcomes of bariatric surgery in men versus women - A matched comparative observational cohort study.
abstract: BACKGROUND
  Despite the high prevalence of morbid obesity, the global frequency of bariatric surgery in men is significantly lower than in women. It is unclear if this is due to the perception of poorer outcomes in men.
  
  
  OBJECTIVE
  Compare weight loss and metabolic outcomes in men vs. women after bariatric surgery.
  
  
  METHODS
  University teaching hospital in North West England.
  
  
  METHODS
  We performed an observational cohort analysis of 79 men matched to 79 women for baseline age (± 5 years), body mass index (BMI; ± 2 kg/m(2)), bariatric procedure (69 gastric bypass and 10 sleeve gastrectomy each), type 2 diabetes (33 each), and continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA; 40 each).
  
  
  RESULTS
  Overall mean (95% confidence interval) reduction in BMI was 17.5 (15.7-19.4) kg/m(2) (P<0.001) at 24 months. There was no significant difference between men and women in mean percentage excess BMI loss (65.8% vs. 72.9%) at 24 months. Likewise, there were significant reductions in blood pressure, glycosylated haemoglobin and total cholesterol-to-high density lipoprotein cholesterol overall but no significant gender differences. Postoperatively, 77.5% of men and 90.0% of women with OSA discontinued CPAP therapy (non-significant).
  
  
  CONCLUSIONS
  Weight loss and metabolic outcomes after bariatric surgery are of similar magnitude in men compared to women. The use of bariatric surgery in eligible men should be encouraged.
authors.affiliation: Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Department of Obesity Medicine and Endocrinology, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kennedy-Dalby
authors.affiliation: Department of Obesity Medicine and Endocrinology, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK. Electronic address: s.adam@doctors.org.uk.
authors.forename: Safwaan
authors.initials: S
authors.lastname: Adam
authors.affiliation: Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Department of Bariatric and Upper Gastrointestinal Surgery, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK.
authors.forename: Basil J
authors.initials: BJ
authors.lastname: Ammori
authors.affiliation: Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Department of Obesity Medicine and Endocrinology, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK.
authors.forename: Akheel A
authors.initials: AA
authors.lastname: Syed
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D001794:Blood Pressure; D002784:Cholesterol / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D002784:Cholesterol; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Gastric bypass; Gender variation; Hypertension; Obesity; Sleeve gastrectomy; Type 2 diabetes