title: [Toward pertinent analytical objectives for haematological parameters].
abstract: Usually, the blood cell counting activity in haematology laboratory uses the comparison of IQC values to the target values proposed by the manufacturer. We intended to improve the monitoring of the proper functioning of our analytical measure system for 17 main haematologic parameters. To set the allowable critical limits of IQC, we propose our reflection based on several elements: benchmark and expert recommendation, clinical requirements, statistical indicators of the laboratory calculated using IQC values (3 levels, 2 different lots, 2 haematology analysers and 2 passage modes) and the EEQ values, during four months. We exploited the reports obtained from the middleware (our own IQC values), and the interlaboratory comparison reports (obtained from SNCS and EuroCell websites) and we compared our performances to the Ricos objectives, to set clearly argued allowable limits for IQC values. Finally, the allowable limits correspond to the imprecision limits stated by Ricos for 14 parameters (desirable for 11 parametres and minimal for 3 parameters) and personalized limits (more exigent than desirable Ricos limits) for 3 parameters of blood cell counting.
authors.affiliation: Laboratoire de biologie, Centre hospitalier de Roanne, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Iobagiu
authors.affiliation: Laboratoire de biologie, Centre hospitalier de Roanne, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Nehar
authors.affiliation: Laboratoire de biologie, Centre hospitalier de Roanne, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Denis
authors.affiliation: Laboratoire de biologie, Centre hospitalier de Roanne, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: de Saint-Trivier
authors.affiliation: Laboratoire de biologie, Centre hospitalier de Roanne, France.
authors.forename: Michelle
authors.initials: M
authors.lastname: Boyer
mesh_terms: D057205:Automation, Laboratory; D001772:Blood Cell Count / Q000592:standards; D019411:Clinical Laboratory Techniques / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D004909:Erythrocyte Indices; D006403:Hematologic Tests / Q000379:methods / Q000639:trends; D006801:Humans; D007753:Laboratories / Q000592:standards; D059021:Laboratory Proficiency Testing; D057230:Limit of Detection; D012016:Reference Values; D015203:Reproducibility of Results
keywords: allowable limit; externalised IQC; quality control