title: Dermoscopy, reflectance confocal microscopy and immunohistochemical analysis in melanocytic lesions with Meyerson's phenomenon.
abstract: BACKGROUND
  Meyerson's phenomenon is characterized by a symmetrical halo of erythema and scale around central, mostly melanocytic lesions.
  
  
  OBJECTIVE
  Our aim was to describe the dermoscopic and reflectance confocal microscopy (RCM) features of melanocytic tumors less frequently associated with Meyerson's phenomenon, with histopathology and immunohistochemistry correlation.
  
  
  METHODS
  Clinical, dermoscopic and RCM images of 4 histopathologically confirmed melanocytic tumors associated with Meyerson's phenomenon (3 dysplastic compound nevi and 1 melanoma) were retrospectively collected, with additional immunohistochemical analysis.
  
  
  RESULTS
  RCM showed in vivo features of both melanocytic and spongiotic nature of the lesion associated with Meyerson's phenomenon, even in cases with absent halo. Our study also supported the involvement of immune-mediated CD4+ T lymphocyte mechanisms and Langerhans cells.
  
  
  CONCLUSIONS
  Our case series supports the potential of RCM in the evaluation of tumoral and inflammatory skin diseases. RCM features of rare Meyerson's melanoma were also described for the first time. © 2014 S. Karger AG, Basel.
authors.affiliation: Department of Dermatology and Venereology, Hospital de Curry Cabral - Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
authors.forename: André
authors.initials: A
authors.lastname: Oliveira
authors.forename: Edith
authors.initials: E
authors.lastname: Arzberger
authors.forename: Cesare
authors.initials: C
authors.lastname: Massone
authors.forename: Regina
authors.initials: R
authors.lastname: Fink-Puches
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
authors.forename: Rainer
authors.initials: R
authors.lastname: Hofmann-Wellenhof
mesh_terms: D000368:Aged; D018949:Antigens, CD1 / Q000032:analysis; D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D046169:Dermoscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000737:chemistry*; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000473:pathology*; D018613:Microscopy, Confocal; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D055815:Young Adult
chemical_list: D018949:Antigens, CD1; D018951:Antigens, CD20; C419393:CD1a antigen; D017252:CD3 Complex