title: Organocatalyzed asymmetric aldol reactions of ketones and β,γ-unsaturated α-ketoesters and phenylglyoxal hydrates.
abstract: Enantioselective aldol reactions of acetophenone with β,γ-unsaturated α-ketoesters and cyclic ketones with phenylglyoxal hydrates were realized with cinchona alkaloid-derived thiourea catalysts. The corresponding aldol products were obtained in high yields and good to excellent diastereoselectivities and enantioselectivities (up to 95% ee).
authors.affiliation: Department of Chemistry, University of Texas at San Antonio , One UTSA Circle, San Antonio, Texas 78249-0698, United States.
authors.forename: Swapna
authors.initials: S
authors.lastname: Konda
authors.forename: Qun-Sheng
authors.initials: QS
authors.lastname: Guo
authors.forename: Manabu
authors.initials: M
authors.lastname: Abe
authors.forename: Huicai
authors.initials: H
authors.lastname: Huang
authors.forename: Hadi
authors.initials: H
authors.lastname: Arman
authors.forename: John C-G
authors.initials: JC
authors.lastname: Zhao