title: Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double-blind, placebo-controlled trial.
abstract: Lipopolysaccharide fromPantoea agglomerans (LPSp) facilitates Ca and P turnover in chicken calvaria and femurs. This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double-blind clinical tests. Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp-containing water for 4 weeks. Oral administration of LPSp tended to suppress the decline in the bone density and the cortical bone thickness in the OVX mice. Moreover, the Ca concentrations were maintained in the OVX-LPSp mice. The effects of LPSp on bone turnover were tested in randomized and double-blind clinical test subjects, who were healthy women aged 40-79 years. The subjects ingested either soy milk without LPSp (control group) or with LPSp (LPSp group) for 3 months. The results showed that the LPSp group on premenopause maintained their bone density compared with the control group pre- and postmenopause. Moreover, these effects were maintained for 2 months postobservation. LPSp maintains bone volume and density in vivo. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.
authors.affiliation: Department of Nutritional Science, Okayama Prefectural University 111 Kuboki, Soja, 719-1197, Japan ; Non-profit Organization, Linking Setouchi Innate Network 2217-16 Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Nakata
authors.affiliation: Non-profit Organization, Linking Setouchi Innate Network 2217-16 Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakata
authors.affiliation: Department of Integrated and Holistic Immunology, Faculty of Medicine, Kagawa University 1750-1 Oaza-ikenobe, Miki-cho, Kida-gun, Kagawa, 761-0793, Japan ; Control of Innate Immunity Technology Research Association 2217-16, Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inagawa
authors.affiliation: Non-profit Organization, Linking Setouchi Innate Network 2217-16 Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan ; Central Park Clinic 1-10-16 Ban-cho, Takamatsu, Kagawa, 760-0017, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Nakamoto
authors.affiliation: Non-profit Organization, Linking Setouchi Innate Network 2217-16 Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan ; Nakagawa Hospital 2-17-17 Mukaishin-machi, Fukuoka-minami, Fukuoka, 811-1345, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshimura
authors.affiliation: Department of Integrated and Holistic Immunology, Faculty of Medicine, Kagawa University 1750-1 Oaza-ikenobe, Miki-cho, Kida-gun, Kagawa, 761-0793, Japan ; Control of Innate Immunity Technology Research Association 2217-16, Hayashi-cho, Takamatsu, Kagawa, 761-0301, Japan ; Niigata University of Pharmacy and Applied Life Sciences 265-1 Higashijima, Akiha, Niigata, 956-8603, Japan.
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
keywords: Bone density; LPS; osteoporosis; premenopause; soy milk