title: Gas chromatography-mass spectrometry and high-performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device.
abstract: The aim of the present study was to investigate the characteristics of Su Xiao Jiu Xin dripping pill absorption in the buccal mucosa of healthy volunteers. This pill is a traditional Chinese medicine that is widely used as an emergency treatment for cardiovascular and cerebrovascular diseases. It is sublingually administered and can be absorbed in the buccal mucosa. In the present study, a method was developed to investigate the absorption characteristics in the buccal mucosa of healthy volunteers via a circulating device by gas chromatography-mass spectrometry and high-performance liquid chromatography. The five main efficacy components associated with cardiovascular and cerebrovascular diseases, which are borneol, isoborneol, ligustilide,n-butylphthalide and ferulic acid, were detected and rapidly absorbed. Among these components, four exhibited good absorption, thus confirming that the method developed is efficient for analysis of the absoption characteristics.
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, P.R. China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Li
authors.affiliation: Tianjin Zhongxin Pharmaceutical Group Corporation Limited, Tianjin 300193, P.R. China.
authors.forename: Daoqing
authors.initials: D
authors.lastname: Xu
authors.affiliation: No.6 Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Co., Qingguang North, Tianjin 300401, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: No.6 Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Co., Qingguang North, Tianjin 300401, P.R. China.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, P.R. China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, P.R. China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
keywords: Su Xiao Jiu Xin dripping pill; absorption; buccal mucosa absorption; cardiovascular and cerebrovascular disease