title: Possible addiction transference from cocaine insufflation to oral bupropion in bipolar patient.
abstract: OBJECTIVE
  Alert for the risk of oral bupropion addiction in patients with cocaine dependence.
  
  
  METHODS
  Single-case study.
  
  
  RESULTS
  After a period of cocaine and alcohol abstinence, a 42-year-old patient started taking oral bupropion to relieve the symptoms of cocaine craving. He increased the bupropion dose up to 2250 mg/d without seizures.
  
  
  CONCLUSIONS
  This case highlights the possibility of oral bupropion addiction after cocaine dependence. To our knowledge, it is the first case in the literature and emphasizes the risk of bupropion's misuse. Therefore, physicians should carefully examine the patient's profile before prescribing it, as well as follow appropriate measures.
authors.affiliation: From the Institute of Psychiatry (CC, MC), the Federal University of Rio de Janeiro, RJ, Brazil; and Clementino Fraga Filho Hospital (AA, MB), Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Costa
authors.forename: Alberto
authors.initials: A
authors.lastname: Araujo
authors.forename: Marco
authors.initials: M
authors.lastname: Brasil
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cruz
mesh_terms: D000284:Administration, Oral; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects; D016739:Behavior, Addictive / Q000523:psychology*; D001714:Bipolar Disorder / Q000523:psychology*; D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects*; D003042:Cocaine / Q000008:administration & dosage*; D066249:Craving / Q000187:drug effects; D006801:Humans; D007327:Insufflation; D008297:Male; D012651:Self Medication / Q000523:psychology*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D003042:Cocaine