title: [Clinical significance of HLA-DRB1 and HLA-DPB1 gene polymorphisms in cirrhosis patients].
abstract: OBJECTIVE
  To investigate the genetic association between cirrhosis and polymorphisms in the genes encoding major histocompatibility complex, class II (HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1).
  
  
  METHODS
  A population of 168 parent/offspring trios, in which the proband had a diagnosis of hepatitis B virus infection with clinical signs of cirrhosis.The HLA-DRB1 and DPB 1 gene polymorphisms of rs24755213 and rs202176660 were detected by PCR and single nucleotide polymorphism (SNP) genotyping.Correlation analysis and haplotype relative risk analysis were carried out.
  
  
  RESULTS
  A/G genotypes were detected in rs24755213 of HLA-DRB1 and C/T genotypes were detected in rs202176660 of DPB1.The rs24755213 allele was associated with cirrhosis (P=0.014), with the G allele identified as a protective factor (Z=-2.33) and the A allele identified as a hazard factor (Z=2.33).The rs202176660 allele was also associated with cirrhosis (P =0.026), with the T allele identified as a protective factor (Z=-2.06) and the C allele identified as a hazard factor (Z=2.06).The haplotypes of G/T and A/C in rs24755213 and rs202176660 respectively were associated with cirrhosis (P =0.037 and 0.002, Z=-2.12 and 2.09 respectively).
  
  
  CONCLUSIONS
  In this group of Chinese patients with hepatitis B virus-related cirrhosis, polymorphisms in the HLA-DRB 1 and DPB1 genes were associated with cimhosis.
authors.affiliation: Department of Infectious Diseases, the Third Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zhao
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Liu
authors.forename: Jingpei
authors.initials: J
authors.lastname: Du
authors.forename: Changan
authors.initials: C
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Dou
authors.forename: Jia
authors.initials: J
authors.lastname: Shang
mesh_terms: D000483:Alleles; D005838:Genotype; D059868:HLA-DP beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D059811:HLA-DRB1 Chains