title: Fetal Bovine Collagen Matrix in the Treatment of a Full Thickness Burn Wound: A Case Report With Long-Term Follow-Up.
abstract: The treatment of full thickness skin wounds commonly associated with large burns continues to represent a challenging clinical entity. The current treatment for large TBSA burns is split thickness autologous skin grafting; however, this treatment often results in poor textural durability, hypertrophic scarring, and fibrotic contractures. In this case report, we describe our experience and long-term follow-up results after the application of fetal bovine collagen (FBC) matrix (PriMatrix, TEI Biosciences, Boston, MA) to burn wounds clinically assessed as full thickness that healed without the need for subsequent skin grafting. The patient presented with 25% TBSA burns and was debrided and covered with FBC on postburn day 7. By postoperative day 12, the patient had large areas of reepithelialization distributed throughout the wound bed. By postoperative day 26, the patient had significantly more areas of wound closure and was discharged. Reepithelialization and repigmentation continued, and long-term follow-up after 26 months demonstrated complete reepithelialization and nearly complete repigmentation, without the appearance of contractures or hypertrophic scarring. This case report highlights the use of FBC as a scaffold capable of dermal regeneration and spontaneous reepithelialization with an excellent long-term functional and cosmetic outcome.
authors.affiliation: From the *Center for Stem Cell Research and Regenerative Medicine, Tulane University, School of Medicine, New Orleans, Louisiana; and †Baton Rouge General Medical Center, Baton Rouge, Louisiana.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Strong
authors.forename: Danielle K
authors.initials: DK
authors.lastname: Bennett
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Spreen
authors.forename: Dhaval V
authors.initials: DV
authors.lastname: Adhvaryu
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Littleton
authors.forename: Ernest J
authors.initials: EJ
authors.lastname: Mencer
mesh_terms: D000818:Animals; D002056:Burns / Q000628:therapy*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016038:Skin Transplantation; D014945:Wound Healing
chemical_list: D003094:Collagen