title: Evaluation profile of thyroid nodule by fnac in the rural population of khanpur kalan, sonepat, haryana.
abstract: BACKGROUND
  Thyroid disease is most common endocrine disorder and is different from other endocrine diseases because of its visible swelling and ease of diagnosis. If left untreated, thyroid disease makes a person more prone for heart disease, infertility and osteoporosis. In India, significant burden of thyroid diseases exist with an estimation of around 42 million cases. The thyroid status and autoimmune status of adult Indian population in the post iodinization phase is largely unknown.
  
  
  OBJECTIVE
  The main objective of this study was to generate valuable epidemiological data regarding the prevalence of thyroid disorders in rural population of Khanpur Kalan, Sonepat in the post-iodinisation era in India. To assess whether thyroid autoimmunity or goitrogens along with environmental factors play role in the development of thyroid.This paper is being presented in view that no such study has been carried out in the rural population of this region in Haryana.
  
  
  METHODS
  The present study was conducted in Department of Pathology, Bhagat Phool Singh Medical College for Women, Khanpur Kalan, Sonepat between August 2011 to July 2013. It included retrospective analysis of cytomorphology of fine needle aspiration cytology material of 206 patients presenting with thyroid nodule in the Department of Pathology.
  
  
  RESULTS
  The commonest age group affected was 31-40 yrs. The female patients (93.4%) outnumbered the male patients (6.6%).The cytomorphological analysis of 206 patients revealed 190 cases (92.2%) of neoplastic lesions, 10 cases (4.8%) were neoplastic and 6 cases (2.9%) had indeterminate cytomorphology. Maximum number (65.5%) of patients was suffering with goiter followed by lymphocytic thyroiditis (26.2%). Amongst the malignant cases three cases were of papillary carcinoma and one case of medullary carcinoma. Two out of the six cases of follicular neoplasm proved to be follicular adenoma on histopathology. Four patients with high T3 levels were under treatment with neomercazole. They showed change in cytomorphology from hyperplasia to colloid goiter. Only one case of acute suppurative thyroiditis was reported which shows rarity of its type.
  
  
  CONCLUSIONS
  The increased prevalence of goiter in this post iodinisation era can be attributed to goitrogens, autoimmune thyroid disease and micronutrient deficiency of iron and selenium. Higher prevalence of autoimmune thyroiditis in females is linked with both genetic and environmental factors such as infection, stress.
authors.affiliation: Associate Professor, Department of Pathology, BPS GMC, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Hemlata T
authors.initials: HT
authors.lastname: Kamra
authors.affiliation: Assistant Professor, Department of Pathology, BPSGMC, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Ruchi
authors.initials: R
authors.lastname: Agarwal
authors.affiliation: Assistant Professor, Department of Pathology, BPSGMC, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Parveen
authors.initials: P
authors.lastname: Rana
authors.affiliation: Professor, Department of Pathology, Post graduate, Institute of Medical Sciences , Rohtak, Haryana, India .
authors.forename: Rajnish
authors.initials: R
authors.lastname: Kalra
authors.affiliation: Professor, Department of Pathology, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Swarn
authors.initials: S
authors.lastname: Kaur
authors.affiliation: Assistant Professor, Department of Pathology, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Amrita
authors.initials: A
authors.lastname: Duhan
authors.affiliation: Demonstrator, Department of Pathology, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Sanjay
authors.initials: S
authors.lastname: Verma
authors.affiliation: Associate Professor, Department of Pathology, Bhagat Phool Singh Medical College for women , Khanpur Kalan, Sonepat, Haryana, India .
authors.forename: Deepti
authors.initials: D
authors.lastname: Agarwal
keywords: Autoimmune thyroiditis; Goiter; Post iodinisation; Thyroid