title: A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co(2+) in semi-aqueous medium: application in cancer cell imaging.
abstract: A new phthalazine based chemosensor was developed for the highly selective and sensitive detection of Co(2+) in the mixed solvent system, CH3CN-H2O (1 : 1, v/v). In the presence of Co(2+), the colour of the solution changed from yellow to green; the absorption maxima of was red-shifted from 383 nm to 435 nm, and the fluorescence of at 550 nm was significantly enhanced. The sensor showed a detection limit down to 25 nM by forming a complex species with Co(2+) in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co(2+) in living cells.
authors.affiliation: School of Chemical Sciences, North Maharashtra University, Jalgaon-425 001, MS, India. kuwaras@gmail.com benderers@rediffmail.com.
authors.forename: Smita
authors.initials: S
authors.lastname: Patil
authors.forename: Rahul
authors.initials: R
authors.lastname: Patil
authors.forename: Umesh
authors.initials: U
authors.lastname: Fegade
authors.forename: Banashree
authors.initials: B
authors.lastname: Bondhopadhyay
authors.forename: Umesh
authors.initials: U
authors.lastname: Pete
authors.forename: Suban K
authors.initials: SK
authors.lastname: Sahoo
authors.forename: Narinder
authors.initials: N
authors.lastname: Singh
authors.forename: Anupam
authors.initials: A
authors.lastname: Basu
authors.forename: Ratnamala
authors.initials: R
authors.lastname: Bendre
authors.forename: Anil
authors.initials: A
authors.lastname: Kuwar
mesh_terms: D003035:Cobalt / Q000032:analysis*; D003116:Color; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000032:analysis*; D018613:Microscopy, Confocal; D008956:Models, Chemical; D057054:Molecular Imaging / Q000295:instrumentation; D009566:Nitrates / Q000737:chemistry; D010793:Phthalazines / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013057:Spectrum Analysis; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D009566:Nitrates; D010793:Phthalazines; D012997:Solvents; D014867:Water; D003035:Cobalt