title: Bifidobacterium longum bacteremia in preterm infants receiving probiotics.
abstract: Administration of probiotics to premature newborns has been shown to prevent necrotizing enterocolitis and reduce all-cause mortality. In our hospital, we documented 2 cases of Bifidobacterium longum subspecies infantis bacteremia in newborns receiving probiotics. By comparative genomics, we confirmed that the strains isolated from each patient originated from the probiotics.
authors.affiliation: Laboratory of Microbial Genomics, Institute of Microbiology, University Hospital Center and University of Lausanne SIB Swiss Institute of Bioinformatics.
authors.forename: Claire
authors.initials: C
authors.lastname: Bertelli
authors.affiliation: Laboratory of Microbial Genomics, Institute of Microbiology, University Hospital Center and University of Lausanne SIB Swiss Institute of Bioinformatics.
authors.forename: Trestan
authors.initials: T
authors.lastname: Pillonel
authors.affiliation: Service of Neonatology.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Torregrossa
authors.affiliation: Laboratory of Bacteriology, Institute of Microbiology.
authors.forename: Guy
authors.initials: G
authors.lastname: Prod'hom
authors.affiliation: Service of Neonatology.
authors.forename: Céline Julie
authors.initials: CJ
authors.lastname: Fischer
authors.affiliation: Laboratory of Microbial Genomics, Institute of Microbiology, University Hospital Center and University of Lausanne Laboratory of Bacteriology, Institute of Microbiology Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Greub
authors.affiliation: Service of Neonatology.
authors.forename: Eric
authors.initials: E
authors.lastname: Giannoni
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016470:Bacteremia / Q000188:drug therapy*; D039941:Bifidobacteriales Infections / Q000382:microbiology*; D001644:Bifidobacterium / Q000302:isolation & purification* / Q000472:pathogenicity; D020345:Enterocolitis, Necrotizing / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D007235:Infant, Premature, Diseases / Q000382:microbiology*; D019102:Infant, Very Low Birth Weight; D010802:Phylogeny; D019936:Probiotics / Q000009:adverse effects* / Q000627:therapeutic use; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents
keywords: Bifidobacterium; genome sequence; newborn; probiotics; sepsis