title: Heightened eating drive and visual food stimuli attenuate central nociceptive processing.
abstract: Hunger and pain are basic drives that compete for a behavioral response when experienced together. To investigate the cortical processes underlying hunger-pain interactions, we manipulated participants' hunger and presented photographs of appetizing food or inedible objects in combination with painful laser stimuli. Fourteen healthy participants completed two EEG sessions: one after an overnight fast, the other following a large breakfast. Spatio-temporal patterns of cortical activation underlying the hunger-pain competition were explored with 128-channel EEG recordings and source dipole analysis of laser-evoked potentials (LEPs). We found that initial pain ratings were temporarily reduced when participants were hungry compared with fed. Source activity in parahippocampal gyrus was weaker when participants were hungry, and activations of operculo-insular cortex, anterior cingulate cortex, parahippocampal gyrus, and cerebellum were smaller in the context of appetitive food photographs than in that of inedible object photographs. Cortical processing of noxious stimuli in pain-related brain structures is reduced and pain temporarily attenuated when people are hungry or passively viewing food photographs, suggesting a possible interaction between the opposing motivational forces of the eating drive and pain.
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Hazel
authors.initials: H
authors.lastname: Wright
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Fallon
authors.affiliation: Unilever R&D, Vlaardingen, The Netherlands.
authors.forename: Timo
authors.initials: T
authors.lastname: Giesbrecht
authors.affiliation: Unilever R&D, Vlaardingen, The Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Thomas
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Joanne A
authors.initials: JA
authors.lastname: Harrold
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Jason C G
authors.initials: JC
authors.lastname: Halford
authors.affiliation: Department of Psychological Sciences, University of Liverpool, Liverpool, United Kingdom; and.
authors.forename: Andrej
authors.initials: A
authors.lastname: Stancak
mesh_terms: D000328:Adult; D001066:Appetite; D002531:Cerebellum / Q000502:physiology; D005260:Female; D005502:Food; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D006815:Hunger / Q000502:physiology*; D066331:Laser-Evoked Potentials; D008297:Male; D059225:Nociception; D020534:Parahippocampal Gyrus / Q000502:physiology*; D010775:Photic Stimulation; D014796:Visual Perception
keywords: EEG; appetite; hunger; pain; source analysis