title: Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.
abstract: The process of mRNA decay and surveillance is considered to be one of the main posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of stable, protein-coding transcripts is normally initiated by removal of the poly(A) tail followed by 5'-cap hydrolysis and degradation of the remaining mRNA body by Xrn1. Alternatively, the exosome complex degrades mRNA in the 3'>5'direction. The newly discovered uridinylation-dependent pathway, which is present in many different organisms, also seems to play a role in bulk mRNA degradation. Simultaneously, to avoid the synthesis of incorrect proteins, special cellular machinery is responsible for the removal of faulty transcripts via nonsense-mediated, no-go, non-stop or non-functional 18S rRNA decay. This review is focused on the major eukaryotic cytoplasmic mRNA degradation pathways showing many similarities and pointing out main differences between the main model-species: yeast, Drosophila, plants and mammals.
authors.affiliation: a Institute of Biochemistry and Biophysics ; Polish Academy of Sciences ; Warsaw , Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Siwaszek
authors.forename: Marta
authors.initials: M
authors.lastname: Ukleja
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dziembowski
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D020871:RNA Stability / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D011506:Proteins; D012333:RNA, Messenger
keywords: Arabidopsis thaliana; Drosophila melanogaster; Saccharomyces cerevisiae; Schizosaccharomyces pombe; human; mRNA decay; mRNA surveillance