title: A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis.
abstract: Apolipoprotein A1 (Apo A-I), the most abundant component of high-density lipoprotein (HDL), is an anti-inflammatory molecule, yet its potential role in the pathogenesis of multiple sclerosis (MS) has not been fully investigated. In this study, Western blot analyses of human plasma showed differential Apo A-I expression in healthy controls compared to MS patients. Further, primary progressive MS patients had less plasma Apo A-I than other forms of MS. Using experimental allergic encephalomyelitis (EAE) as a model for MS, Apo A-I deficient mice exhibited worse clinical disease and more neurodegeneration concurrent with increased levels of pro-inflammatory cytokines compared to wild-type animals. These data suggest that Apo A-I plays a role in the pathogenesis of EAE, a model for MS, creating the possibility for agents that increase Apo A-I levels as potential therapies for MS.
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Meyers
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States.
authors.forename: Chassidy J
authors.initials: CJ
authors.lastname: Groover
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States.
authors.forename: Joshua
authors.initials: J
authors.lastname: Douglas
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
authors.forename: Sangmin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States.
authors.forename: David
authors.initials: D
authors.lastname: Brand
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Levin
authors.affiliation: Research Service VAMC, Memphis, TN 38104, United States; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, United States. Electronic address: lgardne5@uthsc.edu.
authors.forename: Lidia A
authors.initials: LA
authors.lastname: Gardner
mesh_terms: D000328:Adult; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood / Q000172:deficiency / Q000235:genetics*; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism / Q000473:pathology; D005074:Evoked Potentials, Visual / Q000235:genetics / Q000502:physiology; D005260:Female; D005452:Fluoresceins; D005620:Freund's Adjuvant / Q000633:toxicity; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009103:Multiple Sclerosis / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000633:toxicity; D010446:Peptide Fragments / Q000633:toxicity
chemical_list: D016632:Apolipoprotein A-I; D016207:Cytokines; D005452:Fluoresceins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C435731:fluoro jade; C445081:myelin oligodendrocyte glycoprotein (35-55); D005620:Freund's Adjuvant
keywords: Apolipoprotein A-I; EAE; Multiple sclerosis; Neurological disease