title: Clinicopathological analysis of salivary gland carcinomas and literature review.
abstract: Malignant salivary gland tumors are rare and exhibit a broad spectrum of phenotypic heterogeneity. The objective of this study was to investigate prognostic factors in patients with salivary gland carcinomas and review the results in light of other reports. We retrospectively reviewed 40 patients with primary salivary gland carcinomas who were diagnosed and treated at our institution between 1991 and 2014. Of the 40 tumors, 19 (47.5%) were mucoepidermoid carcinomas, 11 (27.5%) were adenoid cystic carcinomas, 7 (17.5%) were acinic cell carcinomas, 2 (5.0%) were myoepithelial carcinomas and 1 (2.5%) was a squamous cell carcinoma. Clinically positive lymph nodes were present in 4 patients (10.0%). As regards clinical stage, 15 cases (37.5%) were stage I, 13 (32.5%) were stage II, 1 (2.5%) was stage III and 11 (27.5%) were stage IVA. The majority of the patients (97.5%) were treated with surgery, of whom 25 (62.5%) received surgery alone and 14 (35.0%) underwent surgery in combination with chemotherapy or chemotherapy and radiotherapy. The median follow-up time for all the patients was 48 months. The disease-specific survival rate at 5 years was 87.1%. We identified a significant correlation between poor survival rate and histological grade (intermediate/high), tumor size (T3/T4), lymph node metastasis (node-positive) and clinical stage (III/IV) using the Kaplan-Meier method (P<0.05 for each). In addition, the Cox proportional hazards regression analysis confirmed that lymph node metastasis and tumor size were independent prognostic factors for disease-specific survival (hazard ratio = 18.7 and 15.1, respectively; P=0.023 and 0.037, respectively). Furthermore, tumor size was found to be a predictive factor regarding recurrence in the multivariate logistic regression analysis (odds ratio = 8.35; P=0.025). Our results suggest that lymph node metastasis and tumor size are significant prognostic factors for patients with salivary gland carcinomas.
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Shigeishi
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Ohta
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Gaku
authors.initials: G
authors.lastname: Okui
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Seino
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Hashikata
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ishida
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Naruse
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Mohammad Zeshaan
authors.initials: MZ
authors.lastname: Rahman
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Uetsuki
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nimiya
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Ono
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimasue
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Higashikawa
authors.affiliation: Department of Public Oral Health, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Sugiyama
authors.affiliation: Department of Oral and Maxillofacial Surgery; Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takechi
keywords: prognostic factor; retrospective study; salivary gland carcinomas