title: Two SAPP2 gene homologs are present in Candida parapsilosis genome.
abstract: Candida parapsilosis produces secreted aspartic proteinases (Saps), which contribute to the virulence of this opportunistic pathogen. Gene family containing as many as 14 sequences potentially encoding secreted aspartic proteinases was identified in C. parapsilosis genome. Of them, SAPP1 and SAPP2 genes have been extensively characterized, but only now do we report that two SAPP2 homologs sharing 91.5 % identity occur in C. parapsilosis genome. Existence of SAPP2 homologs points to unexpected complexity of the SAPP gene family.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nám. 2, 166 10, Prague, Czech Republic, dostalj@uochb.cas.cz.
authors.forename: Jiří
authors.initials: J
authors.lastname: Dostál
authors.forename: Michaela
authors.initials: M
authors.lastname: Merkerová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Vinterová
authors.forename: Iva
authors.initials: I
authors.lastname: Pichová
authors.forename: Olga
authors.initials: O
authors.lastname: Hrušková-Heidingsfeldová
mesh_terms: D000595:Amino Acid Sequence; D057055:Aspartic Acid Proteases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002175:Candida / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D005656:Fungal Proteins; D057055:Aspartic Acid Proteases