title: [Mechanisms of analgesic action of corticotropin-releasing factor on somatic pain sensitivity in rats].
abstract: The article reviews our recent data on the mechanisms of corticotropin-releasing factor (CRF) effect on the somatic pain sensitivity. The involvement of opioid and glucocorticoid receptors and CRF receptors of type 2 in analgesic effect induced by systemic CRF was studied in rats. According to the data obtained CRF receptors of type 2 are involved in CRF-induced analgesia whereas CRF-induced analgesic effect may be manifested in opioid-dependent and opioid-independent forms that apparently depend on pain stimulus and anesthesia. Opioid-independent form of anaIgesia may be provided by glucocorticoids.
authors.forename: N I
authors.initials: NI
authors.lastname: Iarushkina
authors.forename: T R
authors.initials: TR
authors.lastname: Bagaeva
authors.forename: L P
authors.initials: LP
authors.lastname: Filaretova
mesh_terms: D000698:Analgesia; D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage* / Q000378:metabolism; D059226:Nociceptive Pain / Q000188:drug therapy*; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D018019:Receptors, Corticotropin-Releasing Hormone; D011965:Receptors, Glucocorticoid; D003346:Corticotropin-Releasing Hormone