title: CD98 is a promising prognostic biomarker in biliary tract cancer.
abstract: CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman's rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 (LAT1, r=0.562, P<0.001), Ki-67 (r=0.230, P=0.006) and CD34 (r=0.290, P=0.005). Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, and Oncology Center, gunma University Hospital, Showa-machi, Maebashi, Gunma, Japan. kkaira1970@yahoo.co.jp.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kaira
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sunose
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Kanai
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D001650:Bile Duct Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D017734:Bile Ducts, Extrahepatic; D001653:Bile Ducts, Intrahepatic; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D018281:Cholangiocarcinoma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D027261:Fusion Regulatory Protein-1 / Q000032:analysis*; D005706:Gallbladder Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D027283:Large Neutral Amino Acid-Transporter 1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D027261:Fusion Regulatory Protein-1; D019394:Ki-67 Antigen; D027283:Large Neutral Amino Acid-Transporter 1