title: Predictors of extubation failure in neurocritical patients identified by a systematic review and meta-analysis.
abstract: BACKGROUND
  Prediction of extubation failure, particularly in neurocritical patients, is unique and controversial. We conducted a systematic review and meta-analysis to identify the risk factors for extubation failure in these patients.
  
  
  METHODS
  A literature search of databases (MEDLINE, EMBASE, the Cochrane Library, and Web of Science) was performed up to August of 2013 to identify trials that evaluated extubation failure predictors. Included trials were either prospective or retrospective cohort studies.
  
  
  RESULTS
  Nine studies involving 928 participants were included. The systematic review and meta-analysis revealed that the following were predictive for extubation failure: pneumonia, atelectasis, mechanical ventilation of >24 h, a low Glasgow Coma Scale score (7-9T) (OR = 4.96, 95% CI = 1.61-15.26, P = 0.005), the inability to follow commands (OR = 2.07, 95% CI = 1.15-3.71, P = 0.02), especially the command to close the eyes, thick secretion, and no intact gag reflex. Meanwhile, the following were not predictive for extubation failure: sex, secretion volume, coughing upon suctioning, and the inability to follow one command among showing two fingers, wiggling the toes, or coughing on command. Additionally, some traditional weaning parameters were shown to poorly predict extubation failure in neurocritical patients.
  
  
  CONCLUSIONS
  Besides pneumonia, atelectasis, and the duration of mechanical ventilation, other factors that should be taken into consideration in the prediction of extubation failure when neurocritical patients are weaned from tracheal intubation include neurologic abilities (Glasgow Coma Scale score and following commands), the secretion texture, and the presence of a gag reflex.
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Neurology, The second people's hospital of chengdu, Chengdu 610017, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Kaibin
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhenzhou
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Weiguang
authors.initials: W
authors.lastname: Qiao
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Suyue
authors.initials: S
authors.lastname: Pan
mesh_terms: D060666:Airway Extubation; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000628:therapy*; D016017:Odds Ratio; D011379:Prognosis; D012121:Respiration, Artificial; D012307:Risk Factors; D017211:Treatment Failure