title: Homochiral metal-organic framework used as a stationary phase for high-performance liquid chromatography.
abstract: Metal-organic frameworks are promising porous materials. Chiral metal-organic frameworks have attracted considerable attention in controlling enantioselectivity. In this study, a homochiral metal-organic framework [Co(2) (D-cam)(2) (TMDPy)] (D-cam = D-camphorates, TMDPy = 4,4'-trimethylenedipyridine) with a non-interpenetrating primitive cubic net has been used as a chiral stationary phase in high-performance liquid chromatography. It has allowed the successful separation of six positional isomers and six chiral compounds. The good selectivity and baseline separation, or at least 60% valley separation, confirmed its excellent molecular recognition characteristics. The relative standard deviations for the retention time of run-to-run and column-to-column were less than 1.8 and 3.1%, respectively. These results demonstrate that [Co(2) (D-cam)(2) (TMDPy)] may represent a promising chiral stationary phase for use in high-performance liquid chromatography.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Kong
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Duan
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yuan
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D008670:Metals / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008670:Metals; D009930:Organic Chemicals
keywords: Chiral stationary phases; Enantioseparation; High-performance liquid chromatography; Homochiral metal-organic frameworks