title: Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs.
abstract: A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.
authors.forename: Wang
authors.initials: W
authors.lastname: Xiao
authors.forename: Xuan
authors.initials: X
authors.lastname: Zeng
authors.forename: Hang
authors.initials: H
authors.lastname: Lin
authors.forename: Kai
authors.initials: K
authors.lastname: Han
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D016503:Drug Delivery Systems; D004705:Endocytosis; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects; D011108:Polymers / Q000737:chemistry; D012235:Rhodamines / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D014466:Ultraviolet Rays; D047391:alpha-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D003911:Dextrans; D011108:Polymers; D012235:Rhodamines; D047391:alpha-Cyclodextrins; D020782:Matrix Metalloproteinases; D016650:Fluorescein-5-isothiocyanate; C029773:rhodamine B