title: Novel polycarboxylate porphyrins: synthesis, characterization, photophysical properties and preliminary antimicrobial study against Gram-positive bacteria.
abstract: We describe the synthesis, characterization and photophysical properties of two new polycarboxylic photosensitizers. Owing to their structural design, these two compounds show water solubilities larger than natural carboxylic photosensitizers (e.g., protoporphyrin IX, hematoporphyrin, etc.) and also good singlet oxygen quantum yields. These compounds were tested as photo-antimicrobial agents against Staphylococcus aureus and Bacillus cereus strains. Results reveal that their photocytotoxicities are strongly dependent on their amphiphilic character and more precisely the number and position of the carboxylic acid and mesityl substituents.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Jiblaoui
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Leroy-Lhez
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Tan-Sothea
authors.initials: TS
authors.lastname: Ouk
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Grenier
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, 87060 Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008027:Light; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen
keywords: Antibacterial agents; Carboxylic porphyrins; Oxygen singlet quantum yield; Photodynamic antimicrobial chemotherapy; Photosensitizers