title: SnapShot: Medulloblastoma.
abstract: Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification has identified four major subgroups and provides greater opportunity for developing targeted therapies more successful than current conventional therapy.
authors.affiliation: Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Rusert
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
authors.forename: Xiaochong
authors.initials: X
authors.lastname: Wu
authors.affiliation: Departments of Pathology, Ophthalmology, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Charles G
authors.initials: CG
authors.lastname: Eberhart
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.affiliation: Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wechsler-Reya
mesh_terms: D000818:Animals; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D051379:Mice; D009374:Neoplasms, Experimental