title: Alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development.
abstract: The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. cimperat@unina.it.
authors.forename: Concetta
authors.initials: C
authors.lastname: Imperatore
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. aiello@unina.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Aiello
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. filomena.daniello@unina.it.
authors.forename: Filomena
authors.initials: F
authors.lastname: D'Aniello
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. maria.senese@unina.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Senese
authors.affiliation: The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. mlmenna@unina.it.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Menna
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D055808:Drug Discovery; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007448:Invertebrates / Q000737:chemistry*; D008938:Mitosis / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001688:Biological Products; D047428:Protein Kinase Inhibitors; D059004:Topoisomerase I Inhibitors; D018844:Cyclin-Dependent Kinases