title: Mapping functional connectivity using cerebral blood flow in the mouse brain.
abstract: Brain function can be assessed from resting-state functional connectivity (rs-fc) maps, most commonly created by analyzing the dynamics of cerebral hemoglobin concentration. Here, we develop the use of Laser Speckle Contrast Imaging (LSCI) for mapping rs-fc using cerebral blood flow (CBF) dynamics. Because LSCI is intrinsically noisy, we used spatial and temporal averaging to sufficiently raise the signal-to-noise ratio for observing robust functional networks. Although CBF-based rs-fc maps in healthy mice are qualitatively similar to simultaneously-acquired [HbO2]-based maps, some quantitative regional differences were observed. These combined flow/concentration maps might help clarify mechanisms involved in network disruption during disease.
authors.affiliation: Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA.
authors.forename: Karla M
authors.initials: KM
authors.lastname: Bergonzi
authors.affiliation: Department of Radiology, Washington University in St Louis, St Louis, Missouri, USA.
authors.forename: Adam Q
authors.initials: AQ
authors.lastname: Bauer
authors.affiliation: Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Wright
authors.affiliation: 1] Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA [2] Department of Radiology, Washington University in St Louis, St Louis, Missouri, USA [3] Department of Physics, Washington University in St Louis, St Louis, Missouri, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Culver
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D008297:Male; D051379:Mice; D009434:Neural Pathways / Q000502:physiology*