title: Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.
abstract: A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Atigan
authors.initials: A
authors.lastname: Thongtharb
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Ayaka
authors.initials: A
authors.lastname: Takahashi
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nishimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D008204:Lymphangiosarcoma / Q000473:pathology / Q000662:veterinary*; D008223:Lymphoma / Q000662:veterinary; D012983:Soft Tissue Neoplasms / Q000556:secondary / Q000662:veterinary*