title: Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China.
abstract: The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the chemical composition of MEO was characterized, showing that it was mainly composed of menthol, menthone and menthy acetate. MEO exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity. The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.
authors.affiliation: State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.
authors.forename: Zhenliang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Ji Lin Medical College, Ji Lin, 132013, China.
authors.forename: Huiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Fengxian Hospital affiliated to Southern Medical University, Shanghai, 201499, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Fengxian Hospital affiliated to Southern Medical University, Shanghai, 201499, China.
authors.forename: Lianming
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.
authors.forename: Peiming
authors.initials: P
authors.lastname: Yang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002681:China; D003603:Cytotoxins / Q000032:analysis / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D006801:Humans; D008297:Male; D036142:Mentha piperita / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D000067996:RAW 264.7 Cells
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D003603:Cytotoxins; D010938:Plant Oils; D009569:Nitric Oxide; D015232:Dinoprostone