title: The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls.
abstract: OBJECTIVE
  Experimental in vitro studies have shown that bisphenol A affects steroidogenesis, folliculogenesis and ovarian morphology. The aim of this study was to investigate the role of the endocrine disruptor bisphenol A in the aetiopathogenesis of polycystic ovary syndrome (PCOS) in adolescents and its relationship with metabolic parameters, insulin resistance and obesity in this population.
  
  
  METHODS
  A total of 112 girls with PCOS and 61 controls between 13 and 19 years of age were enrolled in the study. Serum bisphenol A levels were measured by high-pressure liquid chromatography. An oral glucose tolerance test was also performed.
  
  
  RESULTS
  Adolescents with PCOS had markedly increased serum bisphenol A levels (mean: 1.1 ng/mL 95% CI: 1.0-1.2) than controls (mean: 0.8 ng/mL 95% CI: 0.6-0.9, p = 0.001). When we compared the subgroups according to obesity, the main factor determining the significant increase in bisphenol A was the presence of PCOS, but not obesity (p = 0.029). Bisphenol A was significantly correlated with total testosterone (r = 0.52), free testosterone (r = 0.44), dehydroepiandrosterone sulphate (r = 0.37) and Ferriman-Gallwey score (r = 0.43) (p < 0.05).
  
  
  CONCLUSIONS
  Adolescents with PCOS had higher serum bisphenol A levels than controls, independent of obesity. Bisphenol A concentrations were significantly correlated with androgen levels, leading us to consider that bisphenol A might play a role in the aetiopathogenesis of PCOS in adolescents.
authors.affiliation: Department of Pediatric Endocrinology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Akın
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kendirci
authors.forename: Figen
authors.initials: F
authors.lastname: Narin
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
authors.forename: Recep
authors.initials: R
authors.lastname: Saraymen
authors.forename: Meda
authors.initials: M
authors.lastname: Kondolot
authors.forename: Selda
authors.initials: S
authors.lastname: Koçak
authors.forename: Ferhan
authors.initials: F
authors.lastname: Elmali
mesh_terms: D000293:Adolescent; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000097:blood; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D010636:Phenols / Q000009:adverse effects* / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000139:chemically induced*; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Adolescents; Bisphenol A; Endocrine disruptors; Polycystic ovary syndrome