title: Assessment of the relationship between entomologic indicators of Aedes aegypti and the epidemic occurrence of dengue virus 3 in a susceptible population, São José do Rio Preto, São Paulo, Brazil.
abstract: The aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. We selected the dengue autochthonous cases that occurred between September 2005 and August 2007 in São José do Rio Preto to calculate incidence rates by month, year and census tracts. The monthly incidence rates of the city were compared to the monthly Breteau indices (BI) of the São José do Rio Region. Between December 2006 and February 2007, an entomological survey was conducted to collect immature forms of Aedes aegypti in Jaguaré, a São José do Rio Preto neighborhood, and to obtain entomological indices. These indices were represented using statistical interpolation. To represent the occurrence of dengue in the Jaguaré neighborhood in 2006 and 2007, we used the Kernel ratio and to evaluate the relationship between dengue and the entomological indices, we used a generalized additive model in a spatial case-control design. Between September 2005 and August 2007, the occurrence of dengue in São José do Rio Preto was almost entirely caused by DENV3, and the monthly incidence rates presented high correlation coefficients with the monthly BI. In Jaguaré neighborhood, the entomological indices calculated by hectare were better predictors of the spatial distribution of dengue than the indices calculated by properties, but the pupae quantification did not show better prediction qualities than the indices based on the container positivity, in relation to the risk of dengue occurrence. The fact that the municipality's population had a high susceptibility to the serotype DENV3 before the development of this research, along with the almost total predominance of the occurrence of this serotype between 2005 and 2007, facilitated the analysis of the epidemiological situation of the disease and allowed us to connect it to the entomological indicators.
authors.affiliation: Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715, 01246-904 São Paulo, SP, Brazil. Electronic address: franciscochiara@usp.br.
authors.forename: Francisco
authors.initials: F
authors.lastname: Chiaravalloti-Neto
authors.affiliation: Diretoria de Combate a Vetores, Superintendência de Controle de Endemias, Rua Paula Souza, 166, 01027-000 São Paulo, SP, Brazil. Electronic address: mariza@sucen.sp.gov.br.
authors.forename: Mariza
authors.initials: M
authors.lastname: Pereira
authors.affiliation: Laboratório de Virologia, Faculdade de Medicina de São José do Rio Preto, Av. Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil. Electronic address: eliane_favaro@yahoo.com.br.
authors.forename: Eliane Aparecida
authors.initials: EA
authors.lastname: Fávaro
authors.affiliation: Laboratório de Vetores de São José do Rio Preto, Superintendência de Controle de Endemias, Av. Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil. Electronic address: mrdibo@yahoo.com.br.
authors.forename: Margareth Regina
authors.initials: MR
authors.lastname: Dibo
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Rodovia Araraquara - Jaú, Km 1, 14801-902 Araraquara, SP, Brasil. Electronic address: amondini@fcfar.unesp.br.
authors.forename: Adriano
authors.initials: A
authors.lastname: Mondini
authors.affiliation: Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900 Hospital Universitário, 2° andar, 14049-900 Ribeirão Preto, SP, Brazil. Electronic address: alrj@fmrp.usp.br.
authors.forename: Antonio Luiz
authors.initials: AL
authors.lastname: Rodrigues-Junior
authors.affiliation: Laboratório de Vetores de São José do Rio Preto, Superintendência de Controle de Endemias, Av. Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil. Electronic address: achierotti@yahoo.com.br.
authors.forename: Ana Patrícia
authors.initials: AP
authors.lastname: Chierotti
authors.affiliation: Laboratório de Virologia, Faculdade de Medicina de São José do Rio Preto, Av. Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil. Electronic address: mnogueira@famerp.br.
authors.forename: Maurício Lacerda
authors.initials: ML
authors.lastname: Nogueira
mesh_terms: D000330:Aedes / Q000254:growth & development* / Q000821:virology; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D003710:Demography; D003715:Dengue / Q000453:epidemiology* / Q000517:prevention & control; D003716:Dengue Virus / Q000145:classification / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D007303:Insect Vectors / Q000254:growth & development*; D011156:Population Density; D012621:Seasons; D014505:Urban Population
keywords: Aedes aegypti; Dengue; Entomologic indicator; Spatial analysis; Temporal analysis