title: Dual inhibition of arachidonic acid pathway by mulberry leaf extract.
abstract: The present work investigates the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of mulberry leaves of variety S-1, S-13 and S-146. The S-146 extract was further evaluated for its efficacy against adjuvant arthritis in albino rats followed by inhibitory potential for COX 1, COX 2 and 5 LOX. The HPLC analysis enumerated the presence of morin, reversterol, scopoletin and 7-hydroxy coumarin as the major constituents. The anti-inflammatory, antipyretic and analgesic activity observed in the present experiment could be accredited to the dual inhibition in the AA pathway. The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.
authors.affiliation: Department of Applied Plant Sciences, SB&BT, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Vidya Vihar, Lucknow, 226 025, Uttar Pradesh, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Chauhan
authors.forename: Uma
authors.initials: U
authors.lastname: Devi
authors.forename: Venkatesh R
authors.initials: VR
authors.lastname: Kumar
authors.forename: Vikas
authors.initials: V
authors.lastname: Kumar
authors.forename: Firoz
authors.initials: F
authors.lastname: Anwar
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaithwas
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D031625:Morus; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D010936:Plant Extracts; D016718:Arachidonic Acid