title: An Immunohistochemical Survey to Evaluate the Expression of CD105 and CD34 in Ameloblastoma and Odontogenic Keratocyst.
abstract: Statement of the Problem : Ameloblastoma is the most common odontogenic tumor which is slow-growing, locally invasive and exhibit specific biologic behavior and high recurrence rate. Likewise, odontogenic keratocyst is a developmental odontogenic cyst that has a high recurrence rate and aggressive behavior. There are limited studies considering the relationship between the angiogenesis factors and the biologic behavior of these lesions.
  
  
  OBJECTIVE
  the aim of this study was to evaluate the mean density of vessels in odontogenic keratocysts and ameloblastoma and investigate its possible relationship with biological behavior of these lesions.
  
  
  METHODS
  In this descriptive-analytic cross-sectional study, 40 cases, comprising 10 odontogenic keratocysts and 30 ameloblastomas (10 plexiform, 10 follicular, and 10 unicystic type) were selected and were stained immuno-histochemically with CD34 and CD105. The micro vessel density was assessed and compared in all groups. T- test for the independent samples' One- way Anova, Wilcoxon test and Tukey tests were adopted for statistical analysis.
  
  
  RESULTS
  A statistically significant difference was observed in mean vascular density (MVD) between the odontogenic keratocyst and ameloblastoma groups concerning the CD105 and CD34 markers (p= 0.005, p= 0.000, respectively). The MVD was significantly higher in ameloblastomas than odontogenic keratocyst. MVD with CD34 was significantly higher than MVD with CD105 in ameloblastomas (p= 0.00).
  
  
  CONCLUSIONS
  It can be suggested that angiogenesis might be one of the mechanisms that is more possible to contribute the aggressive biological behaviors in ameloblastoma rather than odontogenic keratocyst.
authors.affiliation: Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Shokoofeh
authors.initials: S
authors.lastname: Jamshidi
authors.affiliation: Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Massoumeh
authors.initials: M
authors.lastname: Zargaran
authors.affiliation: Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Fahime
authors.initials: F
authors.lastname: Baghaei
authors.affiliation: Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Setareh
authors.initials: S
authors.lastname: Shojaei
authors.affiliation: Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Zare Mahmoodabadi
authors.affiliation: Dept. of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Dehghan
authors.affiliation: Modeling of Noncommunicable Disease Research Center, Dept. of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical sciences, Hamadan, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Moghimbeigi
keywords: Ameloblastoma; Angiogenesis; CD 34; CD105; Odontogenic keratocyst