title: 320-channel active probe for high-resolution neuromonitoring and responsive neurostimulation.
abstract: We present a 320-channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural recording and 64-site neural stimulation at the spatial resolution of 400 μ m and 200 μ m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integer multiples of 200 μm. In the presented configuration, the IC is bonded with a 8 × 8 400 μ m-pitch Utah electrode array (UEA) and up to additional 192 recording channels are used for peripheral neuromonitoring. The 0.35 μ m CMOS circuit array has a total die size of 3.5 mm × 3.65 mm. Each stimulator channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 μA-250 μA square or arbitrary waveform current, occupies 0.02 mm (2), and dissipates 2.76 μ W quiescent power. Each fully differential recording channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035 mm (2) , and consumes 51.9 μ W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo .
authors.forename: Ruslana
authors.initials: R
authors.lastname: Shulyzki
authors.forename: Karim
authors.initials: K
authors.lastname: Abdelhalim
authors.forename: Arezu
authors.initials: A
authors.lastname: Bagheri
authors.forename: M Tariqus
authors.initials: MT
authors.lastname: Salam
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Florez
authors.forename: Jose Luis Perez
authors.initials: JL
authors.lastname: Velazquez
authors.forename: Peter L
authors.initials: PL
authors.lastname: Carlen
authors.forename: Roman
authors.initials: R
authors.lastname: Genov
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004867:Equipment Design; D006624:Hippocampus / Q000502:physiology; D051379:Mice; D008839:Microelectrodes; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology