title: HLA-identical sibling renal transplantation: influence of donor and recipient gender mismatch on long-term outcomes.
abstract: BACKGROUND
  Long-term function of living-related kidney allograft depends on multiple variables. The aim of the present study was to assess the influence of donor and recipient gender mismatch on the short and long-term outcomes in human leukocyte antigen (HLA)-identical sibling renal transplants (SRTs) receiving induction therapy and different immunosuppressive regimens.
  
  
  METHODS
  Twenty-nine recipients who were grafted from their HLA-identical siblings between 1994 and 2008 were divided into 2 groups (same and mismatched) according to gender of donor and recipient. The analyzed variables were age, gender, cholesterol, triglyceride, proteinuria, estimated glomerular filtration rate, weight, body mass index, and serum creatinine at 6, 12, 24, 36, 48, and 60 months, and median follow-up. Univariate and multivariate logistic regression models (when appropriate) were used to evaluate the effects of variables on allograft survival.
  
  
  RESULTS
  The number of male donors (P = .001) and recipient age (P = .019) was significantly higher in the same gender group than in mismatched gender group; there were no relationships between remainder analyzed parameters. Multivariate regression analysis revealed that after median follow-up period of 84 months (range, 60-232) the most important potential factors to significantly influence long-term outcomes were male donor (P = .002), recipient age (P < .001), and donor age (P = .021).
  
  
  CONCLUSIONS
  Our study demonstrated that male donor, and donor and recipient age affected long-term survival of HLA-identical SRTs, supported with antibody induction therapy and lifetime immunosuppression.
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Turkiye Higher Education Hospital, Ankara, Turkey. Electronic address: drmedihaboran@yahoo.com.
authors.forename: Mediha
authors.initials: M
authors.lastname: Boran
authors.affiliation: Department of Thoracic Surgery, Duzce University School of Medicine, Duzce, Turkey.
authors.forename: Mertay
authors.initials: M
authors.lastname: Boran
authors.affiliation: Department of Anesthesiology and Reanimation, Duzce University School of Medicine, Duzce, Turkey.
authors.forename: Ertay
authors.initials: E
authors.lastname: Boran
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D015994:Incidence; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D012737:Sex Factors; D035781:Siblings; D013997:Time Factors; D014019:Tissue Donors; D066027:Transplant Recipients; D014184:Transplantation, Homologous; D014421:Turkey / Q000453:epidemiology
chemical_list: D006680:HLA Antigens