title: Short- and Long-term exercise induced alterations in haemostasis: a review of the literature.
abstract: Although regular exercise is beneficial for health, exercise-related thrombotic events, such as venous thromboembolism and myocardial infarctions, are occasionally observed. These events are characterized by a prothrombotic condition in which interactions between coagulation factors, the vessel wall and the fibrinolytic system play an important role. Apparently, various durations and intensities of exercise have different effects on haemostasis and especially high intensity exercise tends to increase the risk of thrombotic events. However, the mechanisms behind this have not been entirely established. In this review we provide an overview of the various effects of the different intensities and durations of exercise on haemostasis. Overall, the haemostatic profile is mainly affected by the intensity of exercise; and is more pronounced after high (>80%) compared to low intensity (<60%), as reflected by increased platelet and coagulant activity. These findings are in line with the increased risk of exercise-induced thrombotic events during high intensity exercise.
authors.affiliation: Departments of Internal Medicine and Biochemistry, Laboratory for Clinical Thrombosis and Haemostasis Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 (Room H4.330), P.O. Box 616, 6200MD Maastricht, The Netherlands. Electronic address: jelle.posthuma@student.maastrichtuniversity.nl.
authors.forename: Jelle J
authors.initials: JJ
authors.lastname: Posthuma
authors.affiliation: Departments of Internal Medicine and Biochemistry, Laboratory for Clinical Thrombosis and Haemostasis Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 (Room H4.322), P.O. Box 616, 6200MD Maastricht, The Netherlands. Electronic address: p.vandermeijden@maastrichtuniversity.nl.
authors.forename: Paola E J
authors.initials: PE
authors.lastname: van der Meijden
authors.affiliation: Departments of Internal Medicine and Biochemistry, Laboratory for Clinical Thrombosis and Haemostasis Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 (Room H4.344), P.O. Box 616, 6200MD Maastricht, The Netherlands. Electronic address: h.tencate@maastrichtuniversity.nl.
authors.forename: Hugo
authors.initials: H
authors.lastname: Ten Cate
authors.affiliation: Departments of Internal Medicine and Biochemistry, Laboratory for Clinical Thrombosis and Haemostasis Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 (Room H4.326), P.O. Box 616, 6200MD Maastricht, The Netherlands. Electronic address: henri.spronk@maastrichtuniversity.nl.
authors.forename: Henri M H
authors.initials: HM
authors.lastname: Spronk
mesh_terms: D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D015444:Exercise; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D013997:Time Factors
keywords: Blood coagulation; Cardiovascular diseases; Exercise; Haemostasis; Platelets