title: [The distribution of 4-amino-2-phenoxyphenylmethane sulphonamide in the body of warm-blooded animals].
abstract: This study was designed to elucidate the distribution of 4-amino-2-phenoxyphenylmethane sulphonamide in the body of warm-blooded animals (rats) following intragastric administration of this poisonous substance. It was shown that the largest amounts of the unmetabolized parent compound are present in the contents of the stomach and different intestinal segments as well as in the eyes and thymus. 4-N-acetylamino-2-phenoxyphenylmethane sulphonamide, the main biotransformation product of 4-amino-2-phenoxyphenylmethane sulphonamide, is localized chiefly in the eyes, thin intestine contents, Spleen, and heart.
authors.forename: V K
authors.initials: VK
authors.lastname: Shormanov
authors.forename: D A
authors.initials: DA
authors.lastname: Gerasimov
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005123:Eye / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000378:metabolism; D013449:Sulfonamides / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: C000600135:4-amino-2-phenoxyphenylmethanesulfonamide; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide