title: Resolving lipids: lipoxins regulate reverse cholesterol transport.
abstract: Disruptions in cholesterol homeostasis contribute to cardiovascular disease (CVD). In a recent issue of Cell Metabolism, Demetz et al. (2014) report that endogenous lipoxygenase-mediated metabolism of another lipid, arachidonic acid, produces lipoxins that regulate reverse cholesterol transport. These results suggest that lipoxins may represent a novel class of therapeutics for CVD.
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: mspite@partners.org.
authors.forename: Matthew
authors.initials: M
authors.lastname: Spite
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D055442:Metabolome
chemical_list: D016718:Arachidonic Acid; D002784:Cholesterol