title: Activating the cathepsin B1 of a parasite: a major route with alternative pathways?
abstract: With a major leap in a long running saga, Jilkova and colleagues, in this issue of Structure, provide structural and biochemical evidence for a role of sulfated polysaccharides in the activation of parasite digestive proteases.
authors.affiliation: School of Biological Sciences, Medical Biology Centre (MBC), Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland. Electronic address: j.dalton@qub.ac.uk.
authors.forename: John P
authors.initials: JP
authors.lastname: Dalton
authors.affiliation: School of Biological Sciences, Medical Biology Centre (MBC), Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.
authors.forename: Jan
authors.initials: J
authors.lastname: Dvorak
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D015801:Helminth Proteins / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000378:metabolism*
chemical_list: D006025:Glycosaminoglycans; D015801:Helminth Proteins; D002401:Cathepsin B