title: Comparison of the oncologic outcomes of anatomic segmentectomy and lobectomy for early-stage non-small cell lung cancer.
abstract: Interest has been renewed in segmentectomy for non-small cell lung cancer (NSCLC). However, whether the oncologic outcomes are comparable with lobectomy is conflicting. To assess the evidence base, a systematic search identified 31 comparative studies for meta-analysis. No higher local or distant recurrence in segmentectomy compared with lobectomy. Nevertheless, worse outcomes in overall and recurrence-free survival for patients treated with segmentectomy were found. Lobectomy conferred a significant survival advantage compared with segmentectomy for stage I. However, segmentectomy was more suitable for stage IA NSCLC, with survivals equivalent to lobectomy. Further randomized controlled trials are needed to confirm the results.
authors.affiliation: Department of Thoracic Surgery, Jiangsu Province Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Louqian
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Jiangsu Province Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Jiangsu Province Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yin
authors.affiliation: Department of Thoracic Surgery, Jiangsu Province Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Jiangsu Province Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China. Electronic address: xulinjs@yeah.net.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D016896:Treatment Outcome