title: Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence of dementia and cognitive impairment in a population of 70-74-year olds: the InveCe.Ab study.
abstract: The age-specific prevalence rates of dementia vary widely. Studies focusing on specific age groups are needed to provide reliable estimates for healthcare providers and policy makers. We estimated the prevalence of dementia, dementia subtypes and cognitive impairment in "InveCe.Ab" (ClinicalTrials.gov, NCT01345110), a single-step multidimensional population-based study of 70-74-year olds living in Abbiategrasso (Milan, Italy). We also looked for associations with socio-demographic factors and the presence of the apolipoprotein E-ɛ4 allele. The overall dementia prevalence was 3% (95%CI: 2.1-4.1%) [Alzheimer's disease (AD): 1.2% (95%CI 0.6-1.9%); vascular dementia (VD): 1.4% (95%CI: 0.8-2.2%)]. Being single was found to be a risk factor for vascular dementia; subjects born in southern Italy were shown to be at greater risk both of overall dementia and of vascular dementia. The prevalence of cognitive impairment, with or without subjective cognitive complaints (cognitive impairment, no dementia, CIND) was 7.8% (95%CI: 6.4-9.4%). As regards the CIND subgroups, the prevalence of subjects with subjective cognitive complaints (mild cognitive impairment, MCI) was 5.0% (95%CI 3.9-6.3%), while the prevalence of those without MCI (CIND-other) was 2.8% (95%CI: 1.9-3.8). The males had a higher risk of MCI and CIND-other; the older subjects were more likely to have MCI, and those born in north-eastern Italy to have CIND-other. The prevalence of AD was higher among the apolipoprotein E-ɛ4 carriers. Our data highlight the importance of dementia and cognitive impairment in the transitional period from adulthood to old age, and reveal the presence of different associations with socio-demographic and genetic factors.
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy. Electronic address: a.guaita@golgicenci.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Guaita
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy; "C.Golgi" Geriatric Institute, Piazza Golgi 11, 20081 Abbiategrasso, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Vaccaro
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Davin
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy; "C.Golgi" Geriatric Institute, Piazza Golgi 11, 20081 Abbiategrasso, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Colombo
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy; "C.Golgi" Geriatric Institute, Piazza Golgi 11, 20081 Abbiategrasso, Italy.
authors.forename: Silvia Francesca
authors.initials: SF
authors.lastname: Vitali
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Abbondanza
authors.affiliation: Golgi Cenci Foundation, Corso San Martino 10, 20081 Abbiategrasso, Italy; "C.Golgi" Geriatric Institute, Piazza Golgi 11, 20081 Abbiategrasso, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Valle
authors.affiliation: "Mario Negri" Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.affiliation: Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine - University of Pavia, Via Forlanini 2, 27100 Pavia, Italy.
authors.forename: Virginia Valeria
authors.initials: VV
authors.lastname: Ferretti
authors.affiliation: Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine - University of Pavia, Via Forlanini 2, 27100 Pavia, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Villani
mesh_terms: D000367:Age Factors; D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics*; D004522:Educational Status; D005260:Female; D006579:Heterozygote; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D017533:Marital Status; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer's disease; ApoE-ɛ4; Cognitive impairment; Dementia; Prevalence; Risk factors