title: Levels of mRNA for dopaminergic receptor D₅ in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis.
abstract: Interferon (IFN)-β is among the first-line therapies for multiple sclerosis (MS), however the clinical response varies among individuals, and early identification of responders and non-responders would be of critical importance. Here we show that before treatment circulating lymphocytes of MS patients who will respond to IFN-β have higher mRNA levels for the D1-like dopaminergic receptor (DR) D5 in comparison to cells from those who will not respond. Lymphocyte DR D5 is reduced in MS and IFN-β restores their expression and responsiveness. DR D5 mRNA levels in circulating lymphocytes might represent an early marker of response to IFN-β in MS patients.
authors.affiliation: Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy. Electronic address: marco.cosentino@uninsubria.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Cosentino
authors.affiliation: Multiple Sclerosis Center, Hospital 'S. Antonio Abate', Gallarate, VA, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Zaffaroni
authors.affiliation: Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy.
authors.forename: Franca
authors.initials: F
authors.lastname: Marino
mesh_terms: D000328:Adult; D000906:Antibodies / Q000494:pharmacology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D016899:Interferon-beta / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism*; D012372:ROC Curve; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D050641:Receptors, Dopamine D5 / Q000235:genetics* / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D000906:Antibodies; D007155:Immunologic Factors; D012333:RNA, Messenger; D018343:Receptors, Adrenergic, beta-2; D017448:Receptors, Dopamine D2; D050641:Receptors, Dopamine D5; D016899:Interferon-beta; D014446:Tyrosine 3-Monooxygenase
keywords: Dopaminergic receptors; Interferon beta; Lymphocytes; Multiple sclerosis; Tyrosine hydroxylase; β(2)-Adrenoceptors