title: Evaluation of achiral templates with fluxional Brønsted basic substituents in enantioselective conjugate additions.
abstract: Enantioselective conjugate addition of malononitrile to pyrazolidinone-derived enoates proceeds in excellent yields and high enantioselectivities. A comparison of fluxional substituents with and without a Brønsted basic site and their impact on selectivity is detailed. Molecular sieves as an additive were found to be essential to achieve high enantioselectivity.
authors.affiliation: Department of Chemistry and Biochemistry, North Dakota State University , Fargo, North Dakota 58108-6050, United States.
authors.forename: Shinya
authors.initials: S
authors.lastname: Adachi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takeda
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi