title: Semen quality in men with chronic kidney disease and its correlation with chronic kidney disease stages.
abstract: The aim of this study was to assess whether chronic kidney disease (CKD) has any impact on semen quality parameters in men with CKD stage 1-5. Results were collected from 66 men with different CKD stages (age 18-50 years). Age and BMI (body mass index) were recorded for each male. Higher CKD stage had a significant negative linear trend on semen volume (P < 0.05), progressive motility (P < 0.01), nonprogressive motility (P < 0.001), sperm concentration (P < 0.01), total sperm number (P < 0.01), cytoplasmic droplets (P < 0.01), teratozoospermia index (P < 0.05) and accessory gland markers, α-glucosidase activity (P < 0.05), zinc (P < 0.01) and fructose (P < 0.01). BMI per se had no significant effect on semen volume, sperm number, sperm concentration, morphology, α-glucosidase activity, fructose concentration or zinc level. A significant negative correlation between BMI and sexual-hormone-binding globulin (SHBG) (P < 0.01) was observed but not with other sex hormones. Age per se was related to a significant decrease of sperm concentration (P < 0.05), normal forms (P < 0.01) and testosterone level (P < 0.05). Our results indicate that CKD stage per se is a factor determining the number of spermatozoa available in the epididymis for ejaculation, in part independent of age-related decrease of testosterone level and BMI.
authors.affiliation: Department of Medicine, Karolinska Institute and Centre for Andrology and Sexual Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lehtihet
authors.affiliation: Department of Nephrology, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hylander
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D055101:Semen Analysis; D012720:Severity of Illness Index; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone
keywords: Chronic kidney disease; semen quality; subfertility