title: Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.
abstract: Chromium(II) chloride catalyzes the chemoselective cross-coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated in this transformation. Previously challenging substrates, quinolines and isoquinolines, participate in the selective Cr-catalyzed cross-coupling in cyclopentyl methyl ether (CPME) as the solvent. The effective purging of Cr salts is demonstrated by using various solid supports.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich (Germany).
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Steib
authors.forename: Olesya M
authors.initials: OM
authors.lastname: Kuzmina
authors.forename: Sarah
authors.initials: S
authors.lastname: Fernandez
authors.forename: Sushant
authors.initials: S
authors.lastname: Malhotra
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D007202:Indicators and Reagents; D002857:Chromium
keywords: chromium; cross-coupling; magnesium; nitrogen heterocycles