title: The roles and potential therapeutic implications of CXCL4 and its variant CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction.
abstract: Chronic liver allograft dysfunction is the leading cause of patient morbidity and late allograft loss after liver transplantation. The pathogenesis of chronic liver allograft dysfunction remains unknown. Recent studies have demonstrated that CXCL4 and its variant CXCL4L1 are involved in organ damage induced through inflammatory and immune responses throughout all stages of liver transplantation. CXCL4 and CXCL4L1 are low-molecular-weight proteins that have been implicated in hematopoiesis, angiostasis, organ fibrogenesis, mitogenesis, tumor growth and metastasis. The purpose of this review is to discuss the current status and future developments of research into the roles of CXCL4 and CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction. The potential utilization of CXCL4 and CXCL4L1 as therapeutic targets for chronic liver allograft dysfunction will also be discussed.
authors.affiliation: Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of General Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, China. Electronic address: surgeryliubin@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Lu-nan
authors.initials: LN
authors.lastname: Yan
authors.affiliation: Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
authors.forename: Wan-yee
authors.initials: WY
authors.lastname: Lau
mesh_terms: D064591:Allografts; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D016031:Liver Transplantation / Q000009:adverse effects; D058990:Molecular Targeted Therapy; D010978:Platelet Factor 4 / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C064936:PF4V1 protein, human; D010978:Platelet Factor 4
keywords: CXCL4 variants; Chemokine; Chronic allograft dysfunction; Liver transplantation