title: Cancer incidence and mortality in the Czech Republic.
abstract: BACKGROUND
  The Czech Republic ranks among the countries with the highest cancer burden in Europe as well as worldwide. The purpose of this study is to summarize longterm trends in the cancer burden and to provide up-to-date estimates of incidence and mortality rates after 2011.
  
  
  METHODS
  The Czech National Cancer Registry (CNCR) was instituted in 1977 and contains information collected over a 34-year period of standardized registration covering 100% of cancer diagnoses within the entire Czech population. The CNCR analysis is supported by demographic data and by the Death Records Database. An overview of the epidemiology of malignant tumors in the Czech population is available online at www.svod.cz.
  
  
  RESULTS
  All neoplasms, including nonmelanoma skin cancer, reached a crude incidence rate of almost 802 cases per 100,000 men and 681 cases per 100,000 women in 2011. The annual mortality rate exceeded 258 deaths per 100,000 individuals; in other words, more than 27,000 individuals die of cancer each year. The overall incidence of malignancies has increased with a growth index of +27.6% during the last decade (2001- 2011), while the mortality rate has been stabilized over the time span (growth index in 2001- 2011: - 5.0%). Consequently, the prevalence has significantly increased in the observed period and exceeded 475,000 cases in 2011. In addition to demographic aging of the Czech population, the cancer burden has also increased due to the growing incidence of multiple primary tumors (recently more than 15% of the total incidence). The most frequent diagnoses include colorectal cancer, lung cancer, breast cancer, and prostate cancer. Although some neoplasms are increasingly diagnosed at an early stage (e. g. the proportion of stage I or II was 75.3% for female breast cancer and 84.2% for skin melanoma), the numbers of early diagnosed cases are generally insufficient, even in the case of highly prevalent cancers such as colorectal carcinoma (only 46.1% of incident cases are diagnosed at stage I or II, according to recent data).
  
  
  CONCLUSIONS
  Population-based data on malignant tumors are available in the Czech Republic. The data survey can help us define national cancer management priorities. The current priority is to achieve a sustained reduction of cases diagnosed at an advanced stage and reduction of the significant regional differences in diagnostic efficiency.
authors.forename: L
authors.initials: L
authors.lastname: Dusek
authors.forename: J
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authors.lastname: Muzik
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authors.lastname: Maluskova
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authors.lastname: Májek
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authors.lastname: Pavlík
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authors.lastname: Koptíková
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authors.lastname: Melichar
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authors.lastname: Büchler
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authors.lastname: Fínek
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authors.lastname: Cibula
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authors.lastname: Babjuk
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authors.lastname: Svoboda
authors.forename: R
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authors.lastname: Vyzula
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authors.lastname: Ryska
authors.forename: M
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authors.lastname: Ryska
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authors.lastname: Petera
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authors.initials: J
authors.lastname: Abrahámová
mesh_terms: D018153:Czech Republic / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D012042:Registries