title: Meningitis caused by Neisseria Meningitidis, Hemophilus Influenzae Type B and Streptococcus Pneumoniae during 2005-2012 in Turkey. A multicenter prospective surveillance study.
abstract: Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to ≤18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey.
authors.affiliation: a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceyhan
authors.forename: Nezahat
authors.initials: N
authors.lastname: Gürler
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Ozsurekci
authors.forename: Melike
authors.initials: M
authors.lastname: Keser
authors.forename: Ahmet Emre
authors.initials: AE
authors.lastname: Aycan
authors.forename: Venhar
authors.initials: V
authors.lastname: Gurbuz
authors.forename: Nuran
authors.initials: N
authors.lastname: Salman
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Camcioglu
authors.forename: Ener Cagri
authors.initials: EC
authors.lastname: Dinleyici
authors.forename: Sengul
authors.initials: S
authors.lastname: Ozkan
authors.forename: Gulnar
authors.initials: G
authors.lastname: Sensoy
authors.forename: Nursen
authors.initials: N
authors.lastname: Belet
authors.forename: Emre
authors.initials: E
authors.lastname: Alhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Hacimustafaoglu
authors.forename: Solmaz
authors.initials: S
authors.lastname: Celebi
authors.forename: Hakan
authors.initials: H
authors.lastname: Uzun
authors.forename: Ahmet
authors.initials: A
authors.lastname: Faik Oner
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kurugol
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ali Tas
authors.forename: Denizmen
authors.initials: D
authors.lastname: Aygun
authors.forename: Eda
authors.initials: E
authors.lastname: Karadag Oncel
authors.forename: Melda
authors.initials: M
authors.lastname: Celik
authors.forename: Olcay
authors.initials: O
authors.lastname: Yasa
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Coşkun
mesh_terms: D000293:Adolescent; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000134:cerebrospinal fluid; D062665:Epidemiological Monitoring; D005260:Female; D019741:Haemophilus influenzae type b / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000453:epidemiology* / Q000382:microbiology; D008585:Meningitis, Meningococcal / Q000453:epidemiology* / Q000382:microbiology; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000382:microbiology; D060885:Multiplex Polymerase Chain Reaction; D009345:Neisseria meningitidis / Q000302:isolation & purification; D015995:Prevalence; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D014421:Turkey / Q000453:epidemiology
chemical_list: D004269:DNA, Bacterial
keywords: Hib; Meningitis; N. meningitidis; S. pneumoniae; Turkey; epidemiology; etiologic agents; surveillance