title: Dyslipidemia and reduced total antioxidant status in young adult Saudis with prediabetes.
abstract: OBJECTIVE
  Lifestyle related noncommunicable health conditions are having an increasingly negative impact on the health. This study aimed to assess the lipid profile, total antioxidant capacity, and the lifestyle predictors of conversion to prediabetes in young Saudis with prediabetes.
  
  
  METHODS
  One hundred and twenty-one young Saudis with fasting plasma glucose (<125 mg/dl) enrolled in this study who further categorized into normal glucose tolerance "NGT" group (n=86) and prediabetes group (IFG; n=08/IGT; n=27) based on American Association criteria. Venous blood samples were collected at fasting and 2h postprandial from participants. Chemistry parameters and total antioxidant status (TAS) were assayed by standard procedures. Questionnaires were applied to collect information including demographic characteristics, physical activity, and family history to diabetes. Statistical analysis was performed using SPSS version 17.
  
  
  RESULTS
  Compared to NGT subjects, the prediabetics characterized by marked obesity (p=.027), visceral obesity (p=.002), dyslipidemia, significantly increased HbA1c (p=.003), reduced TAS (p<.001), more sedentary lifestyle (p=.010). Positive correlations were documented between FPG, 2-h plasma glucose and HbA1c, BMI, WC, TC, LDL cholesterol, TG while negative correlations with HDL cholesterol, TAS.
  
  
  CONCLUSIONS
  The current study reported that prediabetes condition (in young adult Saudis) was associated with dyslipidemia, reduced total antioxidant status, obesity, central obesity, and physical inactivity compared to those with normoglycemia. Lifestyle modifications (through weight loss, regular physical activity, and healthy diet) should be encouraged especially among young Saudis to prevent the progression to type 2 diabetes and its complications from prediabetes state.
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia. Electronic address: mabdelmarouf@hotmail.com.
authors.forename: Abdelmarouf H
authors.initials: AH
authors.lastname: Mohieldein
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia.
authors.forename: Marghoob
authors.initials: M
authors.lastname: Hasan
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia.
authors.forename: Khalid K
authors.initials: KK
authors.lastname: Al-Harbi
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia.
authors.forename: Sattam S
authors.initials: SS
authors.lastname: Alodailah
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia.
authors.forename: Rajab M
authors.initials: RM
authors.lastname: Azahrani
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Al-Qassim, Saudi Arabia.
authors.forename: Sami A
authors.initials: SA
authors.lastname: Al-Mushawwah
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology*; D005215:Fasting / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011236:Prediabetic State / Q000503:physiopathology*; D011379:Prognosis; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids
keywords: Dyslipidemia; Life style; Prediabetes; Saudi Arabia; Total antioxidant status; Young adults