title: The effect of antireflux treatment on the frequency of awakenings from sleep in patients with Gastroesophageal reflux disease.
abstract: BACKGROUND
  Up to half of gastroesophageal reflux disease (GERD) patients report having heartburn that awakens them from sleep during the night. Recumbent-awake and conscious awakenings from sleep during the night are commonly associated with acid reflux events. The aim of the study was to assess the effect of esomeprazole 40 mg once daily on nighttime acid reflux, frequency of conscious awakenings associated with acid reflux and the recumbent-awake period.
  
  
  METHODS
  Patients with heartburn and/or regurgitation at least three times a week were eligible for this study. All patients underwent upper endoscopy and were evaluated by demographic, Epworth Sleepiness scale, Berlin and GERD symptom checklist questionnaires. Subjects then underwent esophageal pH testing concomitantly with an actigraphy. All subjects were given esomeprazole 40 mg once daily for 7 days and completed a daily symptom record diary. On day 7, subjects repeated the pH test with actigraphy.
  
  
  RESULTS
  Twenty patients (mean age of 48.95 ± 18.69, age range 20-81 years) were enrolled. Esophageal acid exposure parameters, during recumbent-awake, recumbent-asleep, and conscious awakenings were significantly improved on last day of treatment as compared to baseline (p < 0.05). However, the frequency and duration of conscious awakenings and duration of recumbent-awake period did not improve as compared to baseline (p > 0.05).
  
  
  CONCLUSIONS
  While esomeprazole significantly reduced esophageal acid exposure during conscious awakenings and recumbent-awake and asleep periods, it did not decrease the number and duration of conscious awakening or duration of recumbent-awake period.
authors.affiliation: The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson, AZ, USA.
authors.forename: L K
authors.initials: LK
authors.lastname: Jha
authors.forename: C
authors.initials: C
authors.lastname: Maradey-Romero
authors.forename: R
authors.initials: R
authors.lastname: Gadam
authors.forename: T
authors.initials: T
authors.lastname: Hershcovici
authors.forename: O Z
authors.initials: OZ
authors.lastname: Fass
authors.forename: S F
authors.initials: SF
authors.lastname: Quan
authors.forename: J
authors.initials: J
authors.lastname: Guillen
authors.forename: R
authors.initials: R
authors.lastname: Fass
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064098:Esomeprazole / Q000627:therapeutic use*; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006356:Heartburn / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology*; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors; D064098:Esomeprazole
keywords: GERD; actigraphy; heartburn; pH test; sleep