title: Do Ca2+-adsorbing ceramics reduce the release of calcium ions from gypsum-based biomaterials?
abstract: Bone implantable materials based on calcium sulfate dihydrate dissolve quickly in tissue liquids and release calcium ions at very high levels. This phenomenon induces temporary toxicity for osteoblasts, may cause local inflammation and delay the healing process. Reduction in the calcium ion release rate by gypsum could be therefore beneficial for the healing of gypsum-filled bone defects. The aim of this study concerned the potential use of calcium phosphate ceramics of various porosities for the reduction of high Ca(2+) ion release from gypsum-based materials. Highly porous ceramics failed to reduce the level of Ca(2+) ions released to the medium in a continuous flow system. However, it succeeded to shorten the period of high calcium level. It was not the phase composition but the high porosity of ceramics that was found crucial for both the shortening of the Ca(2+) release-related toxicity period and intensification of apatite deposition on the composite. Nonporous ceramics was completely ineffective for this purpose and did not show any ability to absorb calcium ions at a significant level. Moreover, according to our observations, complex studies imitating in vivo systems, rather than standard tests, are essential for the proper evaluation of implantable biomaterials.
authors.affiliation: Chair and Department of Biochemistry and Biotechnology, Medical University in Lublin, Chodzki 1, 20-093 Lublin, Poland. Electronic address: anna.belcarz@umlub.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Belcarz
authors.affiliation: Chair and Department of Biochemistry and Biotechnology, Medical University in Lublin, Chodzki 1, 20-093 Lublin, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Zalewska
authors.affiliation: Department of Materials Engineering, Lublin University of Technology, Nadbystrzycka 36, 20-619 Lublin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pałka
authors.affiliation: Institute of Agrophysics, Polish Academy of Sciences, Doswiadczalna 4, P.O. Box 201, 20-290 Lublin, Poland.
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Hajnos
authors.affiliation: Chair and Department of Biochemistry and Biotechnology, Medical University in Lublin, Chodzki 1, 20-093 Lublin, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Ginalska
mesh_terms: D000327:Adsorption; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D002118:Calcium / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D002133:Calcium Sulfate / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods; D016062:Porosity; D019736:Prostheses and Implants
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D007477:Ions; C020243:calcium phosphate; D002118:Calcium; D002133:Calcium Sulfate
keywords: Apatite deposition; Calcium phosphate; Gypsum; Implantable materials; Ion adsorption; Ion release