title: Association of premature hair graying with family history, smoking, and obesity: a cross-sectional study.
abstract: BACKGROUND
  Many researchers have been concerned about the association of hair graying with systemic diseases. However, the common factors associated with hair graying and systemic diseases have not been elucidated.
  
  
  OBJECTIVE
  This study aimed to identify risk factors for premature hair graying (PHG) in young men.
  
  
  METHODS
  We conducted a cross-sectional study using questionnaires in young men. After a pilot study that included 1069 men, we surveyed 6390 men younger than 30 years about their gray hair status and various socioclinical characteristics.
  
  
  RESULTS
  The age of participants in the main survey was 20.2 ± 1.3 years (mean ± SD). Of the 6390 participants, 1618 (25.3%) presented with PHG. Family history of PHG (odds ratio [OR], 12.82), obesity (OR, 2.61), and >5 pack-years history of smoking (OR, 1.61) were significantly associated with PHG. In the multivariate analysis, family history of PHG (OR, 2.63) and obesity (OR, 2.22) correlated with the severity of PHG.
  
  
  CONCLUSIONS
  Owing to the use of questionnaires, the possibility of recall bias exists. Women were not evaluated in this study.
  
  
  CONCLUSIONS
  Smoking, family history of PHG, and obesity are important factors associated with PHG.
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
authors.forename: Hyoseung
authors.initials: H
authors.lastname: Shin
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyeong Ho
authors.initials: HH
authors.lastname: Ryu
authors.affiliation: 306 Supplementary Battalion, Korea Army, Uijungbu, Korea.
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seongmoon
authors.initials: S
authors.lastname: Jo
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sihyeok
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Mira
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ohsang
authors.initials: O
authors.lastname: Kwon
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. Electronic address: sj.jo@snu.ac.kr.
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Jo
mesh_terms: D000328:Adult; D015897:Comorbidity; D003430:Cross-Sectional Studies; D006200:Hair Color / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008889:Military Personnel; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D010859:Pigmentation Disorders / Q000453:epidemiology / Q000235:genetics; D010865:Pilot Projects; D011159:Population Surveillance; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012536:Scalp Dermatoses / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology*; D013315:Stress, Psychological / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: body mass index; gray hair; obesity; premature hair graying; smoking