title: Stationary chest tomosynthesis using a carbon nanotube x-ray source array: a feasibility study.
abstract: Chest tomosynthesis is a low-dose, quasi-3D imaging modality that has been demonstrated to improve the detection sensitivity for small lung nodules, compared to 2D chest radiography. The purpose of this study is to investigate the feasibility and system requirements of stationary chest tomosynthesis (s-DCT) using a spatially distributed carbon nanotube (CNT) x-ray source array, where the projection images are collected by electronically activating individual x-ray focal spots in the source array without mechanical motion of the x-ray source, detector, or the patient. A bench-top system was constructed using an existing CNT field emission source array and a flat panel detector. The tube output, beam quality, focal spot size, system in-plane and in-depth resolution were characterized. Tomosynthesis slices of an anthropomorphic chest phantom were reconstructed for image quality assessment. All 75 CNT sources in the source array were shown to operate reliably at 80 kVp and 5 mA tube current. Source-to-source consistency in the tube current and focal spot size was observed. The incident air kerma reading per mAs was measured as 74.47 uGy mAs(-1) at 100 cm. The first half value layer of the beam was 3 mm aluminum. An average focal spot size of 2.5  ×  0.5 mm was measured. The system MTF was measured to be 1.7 cycles mm(-1) along the scanning direction, and 3.4 cycles mm(-1) perpendicular to the scanning direction. As the angular coverage of 11.6°-34°, the full width at half maximum of the artifact spread function improved greatly from 9.5 to 5.2 mm. The reconstructed tomosynthesis slices clearly show airways and pulmonary vascular structures in the anthropomorphic lung phantom. The results show the CNT source array is capable of generating sufficient dose for chest tomosynthesis imaging. The results obtained so far suggest an s-DCT using a distributed CNT x-ray source array is feasible.
authors.affiliation: Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Shan
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Tucker
authors.forename: Yueh Z
authors.initials: YZ
authors.lastname: Lee
authors.forename: Michael D
authors.initials: MD
authors.lastname: Heath
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.forename: David H
authors.initials: DH
authors.lastname: Foos
authors.forename: Jianping
authors.initials: J
authors.lastname: Lu
authors.forename: Otto
authors.initials: O
authors.lastname: Zhou
mesh_terms: D016477:Artifacts; D005240:Feasibility Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D037742:Nanotubes, Carbon / Q000737:chemistry*; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000295:instrumentation* / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D013902:Radiography, Thoracic / Q000295:instrumentation* / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods; D014965:X-Rays
chemical_list: D037742:Nanotubes, Carbon