title: Initial evidence demonstrating the association between the vascular status in surgically resected renal parenchymal pathology and sexual function.
abstract: Our goal is to evaluate the association between histopathology of glomerulosclerosis (GS) and atherosclerosis (AS) in the nephrectomized normal parenchyma together with patients' background, and erectile dysfunction (ED) of patients treated with radical nephrectomy (RN) for renal cell carcinoma (RCC). ED was assessed with the International Index of Erectile Function in 65 patients who were less than age 70 years at the time of questionnaire. Glomeruli status was assessed by the extent of global GS. AS was graded based on lumen occlusion and frequency of involvement. Patients' backgrounds included any comorbidities, post-RN renal insufficiency, tumor pathology, demographics and social status. The presence of diabetes mellitus and lack of a spouse were independent predictors for severe ED, whereas G0/1 AS was an independent predictor for mild/no ED. The extent of global GS was significantly lower in patients with mild/no ED than in other patients. Our study represents the first report identifying healthy arterial status in the renal parenchyma as a significant indicator of favorable erectile function and that the evaluation of AS severity is not a superior indicator of severe ED in the presence of comorbidities or social status among patients treated with RN.
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sejima
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwamoto
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Masago
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Morizane
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yao
authors.affiliation: Division of Organ Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Umekita
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Honda
authors.affiliation: Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takenaka
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000150:complications / Q000473:pathology / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000601:surgery*; D015331:Cohort Studies; D015897:Comorbidity; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000473:pathology / Q000601:surgery; D006801:Humans; D018783:Impotence, Vasculogenic / Q000209:etiology* / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011183:Postoperative Complications / Q000473:pathology*; D011237:Predictive Value of Tests; D012077:Renal Artery / Q000473:pathology; D012079:Renal Circulation; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires