title: Efficacy and security of ivermectin given orally to rats naturally infected with Syphacia spp., Giardia spp. and Hymenolepis nana.
abstract: The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe and highly effective treatment for Giardia spp. and Hymenolepis nana in laboratory rat colonies. The drug can be easily and safely administered using drinking water. This simple regimen should control pinworm infection (Syphacia muris), a problem that can be endemic in laboratory colonies. Experiments using healthy animals are likely to generate more consistent results, thereby requiring a reduced number of animals per group.
authors.affiliation: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil vanessafoletto@uol.com.br.
authors.forename: V R S
authors.initials: VR
authors.lastname: Foletto
authors.affiliation: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Vanz
authors.affiliation: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Gazarini
authors.affiliation: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
authors.forename: C A J
authors.initials: CA
authors.lastname: Stern
authors.affiliation: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
authors.forename: C R
authors.initials: CR
authors.lastname: Tonussi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D041981:Gastrointestinal Tract / Q000469:parasitology; D005872:Giardia / Q000187:drug effects; D005873:Giardiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D006925:Hymenolepiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D048189:Hymenolepis nana / Q000187:drug effects; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010123:Oxyuriasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010124:Oxyuroidea / Q000187:drug effects; D010270:Parasite Egg Count / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000188:drug therapy* / Q000469:parasitology; D012377:Rodentia
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin
keywords: Giardia; Hymenolepis; Syphacia; faecal examination; ivermectin; laboratory animals