title: Synthesis of fused 1-aminoindole polycycles by a sequence of palladium-catalyzed N–H and C(sp2)–H arylations.
abstract: An efficient Pd-catalyzed selective intramolecular arylation of functionalized N,N′-substituted 1-aminoindoles has been reported. In all cases, the reactions take place rapidly in DMA and efficiently proceed in the presence of a Pd(OAc)2/Dpephos catalytic system, furnishing the fused indolo[2,1-a]phthalazines in high yields. Additionally, the one-pot double C–H arylation at positions C-2 and C-3 of N,N′-substituted 1-aminoindoles is effective and leads to unknown complex scaffolds of biological interest.
authors.forename: Thi Thanh Huyen
authors.initials: TT
authors.lastname: Luong
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.forename: Mouad
authors.initials: M
authors.lastname: Alami
authors.forename: Samir
authors.initials: S
authors.lastname: Messaoudi
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006860:Hydrogen Bonding; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D007211:Indoles; D010165:Palladium; C512101:5-aminoindole