title: Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients.
abstract: OBJECTIVE
  Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofolate reductase (MTHFR, C677T) mutation in women with recurrent pregnancy loss.
  
  
  METHODS
  This descriptive study was carried out in the Department of Obstetrics and Gynaecology, Harran University School of Medicine, and included a total of 1,507 women with histories of recurrent pregnancy loss between January 2010 and June 2013. The mutations were assessed by using the polymerase chain reaction.
  
  
  RESULTS
  The homozygous mutation frequencies of FVL, prothrombin, and MTHFR were found to be 3 (0.20%), 0 and 125 (8.29%), and the heterozygous mutation frequencies were 83 (5.51%), 61 (4.05%), and 612 (40.61%), respectively. Among the 86 FVL mutation patients, 38 also had accompanying prothrombin and MTHFR mutations.
  
  
  CONCLUSIONS
  Since the homozygous forms of the FVL-prothrombin gene mutations have low incidences and MTHFR mutation is similar to a healthy population, preconceptional thromogenic gene mutations screening seems to be controversial.
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Incebiyik
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Nese Gul
authors.initials: NG
authors.lastname: Hilali
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoglu
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
authors.affiliation: Department of Medical Biology, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Akbas
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Avni
authors.initials: A
authors.lastname: Kilic
authors.affiliation: Department of Gynecology and Obstetrics, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
keywords: Factor V Leiden; Methylenetetrahydrofolate reductas; Prevalence; Prothrombin; Recurrent pregnancy loss