title: Clinical management of multiple sclerosis and neuromyelitis optica with therapeutic monoclonal antibodies: approved therapies and emerging candidates.
abstract: Therapeutic monoclonal antibodies (mAbs) are a relatively novel class of drugs that has substantially advanced immunotherapy for patients with multiple sclerosis. The advantage of these agents is that they bind specifically and exclusively to predetermined proteins or cells. Natalizumab was the first mAb in neurology to obtain approval. It is also considered one of the most potent options for annualized relapse rate reduction among available therapeutic options. Alemtuzumab is currently also approved in several countries. Several mAbs have been tested in clinical studies in multiple sclerosis. Here, we review the history of drug development of therapeutic mAbs and their classification. Furthermore, we outline the putative mechanisms of action, clinical evidence and safety of approved mAbs and those in different stages of clinical development in multiple sclerosis and neuromyelitis optica.
authors.affiliation: UT Southwestern, Dallas, TX, USA.
authors.forename: Divyanshu
authors.initials: D
authors.lastname: Dubey
authors.forename: Bernd C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Hartung
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.forename: William A
authors.initials: WA
authors.lastname: Miller-Little
authors.forename: Olaf
authors.initials: O
authors.lastname: Stuve
mesh_terms: D000074323:Alemtuzumab; D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D000069442:Natalizumab; D009471:Neuromyelitis Optica / Q000188:drug therapy* / Q000473:pathology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000069442:Natalizumab; D000074323:Alemtuzumab
keywords: MS; monoclonal antibodies; multiple sclerosis; pharmacology; therapies