title: Prevalence and clinicopathological features of autoimmune pancreatitis in Japanese patients with inflammatory bowel disease.
abstract: OBJECTIVE
  The purpose of this study was to clarify the clinicopathological characteristics of autoimmune pancreatitis (AIP) in Japanese patients with inflammatory bowel disease (IBD).
  
  
  METHODS
  The clinicopathological findings of 7 patients with IBD whose definite AIP was diagnosed in our hospital according to the International Consensus Diagnostic Criteria were reviewed.
  
  
  RESULTS
  Five (0.5%) of 961 patients with ulcerative colitis (UC) and 2 (0.3%) of 790 patients with Crohn disease had AIP. All of 7 patients whose AIP was diagnosed were type 2. The rate of elevated values of serum immunoglobulin G4 was 0%. Most patients with the diagnosis of IBD preceded that of AIP, and disease activity of IBD were active. Granulocyte epithelial lesion is similar to the cryptitis seen in colonic tissue of UC. All of 7 patients were given corticosteroids, immunomodulators, and/or biological agents for IBD. One patient had a recurrence.
  
  
  CONCLUSIONS
  The frequency of AIP in Japanese patients with IBD was low. All cases were type 2 and responded well to corticosteroids, immunomodulators, and biological agents. Autoimmune pancreatitis in UC patients may be an extraintestinal manifestation of UC.
authors.affiliation: From the Department of *Gastroenterology, and †Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ueki
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Ryohei
authors.initials: R
authors.lastname: Minoda
authors.forename: Toru
authors.initials: T
authors.lastname: Maruo
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Matsumura
authors.forename: Eijiro
authors.initials: E
authors.lastname: Noma
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mitsuyasu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Otani
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Aomi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yano
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisabe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ota
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology* / Q000276:immunology; D001688:Biological Products / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology* / Q000276:immunology; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology* / Q000276:immunology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007155:Immunologic Factors / Q000627:therapeutic use; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology* / Q000276:immunology; D015995:Prevalence; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D001688:Biological Products; D015415:Biomarkers; D007074:Immunoglobulin G; D007155:Immunologic Factors