title: Light chain deposition disease and proximal tubulopathy in two successive kidney allografts.
abstract: Light chain proximal tubulopathy (LCPT) is a rare kidney disease associated with plasma cell dyscrasias, characterized by light chain deposits in the proximal tubular cells, with or without crystal formation. We describe an exceptional case of LCPT without crystal formation in a kidney allograft, in a patient who underwent two renal transplants for a light chain deposition disease (LCDD) complicating smoldering myeloma. This is the first description of this association in successive kidney allografts. We concisely describe pathology of LCDD and LCPT and discuss potential pathophysiological mechanisms relating these two conditions.
authors.forename: Fanny
authors.initials: F
authors.lastname: Drieux
authors.forename: Marie-Charlotte
authors.initials: MC
authors.lastname: Loron
authors.forename: Arnaud
authors.initials: A
authors.lastname: Francois
authors.forename: Dominique
authors.initials: D
authors.lastname: Bertrand
authors.forename: Isabelle
authors.initials: I
authors.lastname: Etienne
authors.forename: Sebastien
authors.initials: S
authors.lastname: Bender
authors.forename: Michel
authors.initials: M
authors.lastname: Godin
authors.forename: Dominique
authors.initials: D
authors.lastname: Guerrot
mesh_terms: D000328:Adult; D064591:Allografts; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D010265:Paraproteinemias / Q000150:complications*
chemical_list: D007147:Immunoglobulin Light Chains