title: Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population.
abstract: Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).
authors.affiliation: Centre for Public Health, Queen's University Belfast, United Kingdom.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Douglas
authors.affiliation: Centre for Public Health, Queen's University Belfast, United Kingdom.
authors.forename: Dwaine R
authors.initials: DR
authors.lastname: Vance
authors.affiliation: TrinSeq, Trinity Genome Sequencing Lab, Department of Psychiatry, Institute of Molecular Medicine, Trinity College, Dublin, Ireland.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Kenny
authors.affiliation: TrinSeq, Trinity Genome Sequencing Lab, Department of Psychiatry, Institute of Molecular Medicine, Trinity College, Dublin, Ireland.
authors.forename: Derek W
authors.initials: DW
authors.lastname: Morris
authors.affiliation: 1] Centre for Public Health, Queen's University Belfast, United Kingdom [2] Regional Nephrology Unit, Belfast City Hospital, Belfast, United Kingdom.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Maxwell
authors.affiliation: Centre for Public Health, Queen's University Belfast, United Kingdom.
authors.forename: Amy Jayne
authors.initials: AJ
authors.lastname: McKnight
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D050259:Genes, Mitochondrial; D056726:Genetic Association Studies; D054629:Genome, Mitochondrial; D023281:Genomics; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000209:etiology*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D016030:Kidney Transplantation; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results