title: Effects of renal denervation on atrial arrhythmogenesis.
abstract: Atrial fibrillation is the most common sustained arrhythmia and is associated with significant morbidity and mortality. In addition to mechanisms such as atrial stretch and atrial remodeling, the activity of the autonomic nervous system has also been suggested to contribute to the progression from paroxysmal to persistent atrial fibrillation. Catheter-based renal denervation was introduced as a minimally invasive approach to reduce renal and whole body sympathetic activation with accompanying blood pressure reduction and left-ventricular morphological and functional improvement in drug-resistant hypertension. This review focuses on the potential effects of renal denervation on different arrhythmogenic mechanisms in the atrium and discusses potential anti-remodeling effects in atrial fibrillation patients with hypertension, heart failure and sleep apnea.
authors.affiliation: Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Linz
authors.forename: Arne van
authors.initials: Av
authors.lastname: Hunnik
authors.forename: Christian
authors.initials: C
authors.lastname: Ukena
authors.forename: Felix
authors.initials: F
authors.lastname: Mahfoud
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ewen
authors.forename: Sander
authors.initials: S
authors.lastname: Verheule
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schotten
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D003714:Denervation; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007668:Kidney / Q000294:innervation*; D012891:Sleep Apnea Syndromes / Q000150:complications
keywords: ablation; atrial fibrillation; heart failure; hypertension; renal denervation