title: The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion.
abstract: Pituitary adenylate cyclase activating polypeptide (PACAP ) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycin- and cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.
authors.affiliation: PTE-MTA PACAP "Lendület" Research Team Department of Anatomy Pécs Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: László
authors.affiliation: PTE-MTA PACAP "Lendület" Research Team Department of Anatomy Pécs Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Kiss
authors.affiliation: PTE-MTA PACAP "Lendület" Research Team Department of Anatomy Pécs Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Horváth
authors.affiliation: University of Pécs Department of Surgery Pécs Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Szakály
authors.affiliation: PTE-MTA PACAP "Lendület" Research Team Department of Anatomy Pécs Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tamás
authors.affiliation: PTE-MTA PACAP "Lendület" Research Team Department of Anatomy Pécs Hungary.
authors.forename: Dóra
authors.initials: D
authors.lastname: Reglődi
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D007674:Kidney Diseases / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000008:administration & dosage / Q000378:metabolism*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism; D015427:Reperfusion Injury / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
keywords: Kidney; PACAP; ischemia/reperfusion; renoprotection