title: Preparation and characterization of new biologically active polyurethane foams.
abstract: Biologically active polyurethane foams are the fast-developed alternative to many applications of biomedical materials. Due to the polyurethane structure features and foam technology it is possible to incorporate into their structure the biologically active compounds of target purpose via structural-chemical modification of macromolecule. A series of new biologically active polyurethane foams (PUFs) was synthesized with polyethers (MM 2500-5000), polyesters MM (500-2200), 2,4(2,6) toluene diisocyanate, water as a foaming agent, catalysts, foam stabilizers and functional compounds. Different functional compounds: 1,4-di-N-oxy-2,3-bis-(oxymethyl)-quinoxaline (DOMQ), partial sodium salt of poly(acrylic acid) and 2,6-dimethyl-N,N-diethyl aminoacetatanilide hydrochloride were incorporated into the polymer structure/composition due to the chemical and/or physical bonding. Structural peculiarities of PUFs were studied by FTIR spectroscopy and X-ray scattering. Self-adhesion properties of PUFs were estimated by measuring of tensile strength at break of adhesive junction. The optical microscopy method was performed for the PUF morphology studies. Toxicological estimation of the PUFs was carried out in vitro and in vivo. The antibacterial action towards the Gram-positive and Gram-negative bacteria (Escherichia coli ATC 25922, E. coli ATC 2150, Klebsiella pneumoniae 6447, Staphylococcus aureus 180, Pseudomonas aeruginosa 8180, Proteus mirabilis F 403, P. mirabilis 6054, and Proteus vulgaris 8718) was studied by the disc method on the solid nutrient. Physic-chemical properties of the PUFs (density, tensile strength and elongation at break, water absorption and vapor permeability) showed that all studied PUFs are within the operational requirements for such materials and represent fine-cellular foams. Spectral studies confirmed the incorporation of DOMQ into the PUF's macrochain. PUFs are characterized by microheterogeneous structure. They are antibacterially active, non-toxic materials with high affinity to the tissue body, self-adhesive properties and local anesthetic effect.
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Savelyev
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Vitali
authors.initials: V
authors.lastname: Veselov
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Markovskaya
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Olga
authors.initials: O
authors.lastname: Savelyeva
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Elena
authors.initials: E
authors.lastname: Akhranovich
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Natalya
authors.initials: N
authors.lastname: Galatenko
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Robota
authors.affiliation: Institute of Macromolecular Chemistry, NAS of Ukraine, 48 Kharkovskoe shosse, 02160 Kiev, Ukraine. Electronic address: travinskaya-tamara@rambler.ru.
authors.forename: Tamara
authors.initials: T
authors.lastname: Travinskaya
mesh_terms: D000268:Adhesiveness; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005740:Gases / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D010539:Permeability; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D005740:Gases; D011140:Polyurethanes; D014867:Water; C028279:polyurethane foam
keywords: Biological activity; Non-toxicity; Polyurethane foam; Self-adhesive properties