title: Serial aEEG recordings in a cohort of extremely preterm infants: feasibility and safety.
abstract: OBJECTIVE
  Amplitude-integrated electroencephalography (aEEG) monitoring is increasing in the neonatal population, but the safety and feasibility of performing aEEG in extremely preterm infants have not been systematically evaluated.
  
  
  METHODS
  Inborn infants 23(0/7) to 28(6/7) weeks gestation or birth weight 401 to 1000 g were eligible. Serial, 6-h aEEG recordings were obtained from first week of life until 36 weeks postmenstrual age. Adverse events were documented, and surveys evaluated the impact of the aEEGs on routine care. Success of performing aEEGs according to protocol and aEEG quality were assessed.
  
  
  RESULTS
  A total of 102 infants were enrolled, with 755 recordings performed. 83% of recordings were performed according to schedule, and 96% were without adverse event. Bedside nurses reported no interference with routine care for 89% of recordings. 92% of recordings had acceptable signal quality.
  
  
  CONCLUSIONS
  Serial aEEG monitoring is safe in preterm infants, with few adverse events and general acceptance by nursing staff.
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Davis
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Gantz
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA.
authors.forename: B
authors.identifier: 0000000260121168
authors.initials: B
authors.lastname: Do
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: S
authors.initials: S
authors.lastname: Shankaran
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: S E G
authors.initials: SE
authors.lastname: Hamrick
authors.affiliation: Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Kennedy
authors.affiliation: Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Tyson
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Chalak
authors.affiliation: Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Laptook
authors.affiliation: Department of Pediatrics, Duke University, Durham, NC, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Goldstein
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Hintz
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
authors.forename: A
authors.initials: A
authors.lastname: Das
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Higgins
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Ball
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: E C
authors.initials: EC
authors.lastname: Hale
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Van Meurs
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D015331:Cohort Studies; D004569:Electroencephalography / Q000009:adverse effects* / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D009741:Nursing Staff, Hospital; D055815:Young Adult