title: Effect of ramosetron on the QT interval during sevoflurane anaesthesia in children: a prospective observational study.
abstract: BACKGROUND
  We investigated the effects of concomitant administration of sevoflurane and ramosetron on the QT interval, the interval between the peak and end of the T wave (Tpe) and Tpe/QT ratio in children.
  
  
  OBJECTIVE
  To compare the effects of concomitant administration of ramosetron and sevoflurane on heart rate corrected interval with Bazett's formula (QTc), Tpe interval and Tpe/QT ratio.
  
  
  METHODS
  A prospective observational study.
  
  
  METHODS
  Elective orthopaedic surgery with patient-controlled analgesia.
  
  
  METHODS
  Forty children aged between 3 and 12 years.
  
  
  METHODS
  ECG recordings were collected before induction (BASE), before sevoflurane administration (SEVO) and after the administration of ramosetron (SEVO and R).
  
  
  METHODS
  The heart rate corrected interval with Bazett's formula (QTc), Tpe interval and Tpe/QT ratio were calculated and the changes were analysed using repeated-measures analysis of variance (ANOVA).
  
  
  RESULTS
  The QTc interval at BASE was 388.5 ± 29.3 ms. It increased with sevoflurane anaesthesia to 414.9 ± 21.4 ms and did not change with the administration of ramosetron (418.2 ± 23.0 ms). The Tpe interval and Tpe/QT ratio did not differ between measurements. No ventricular arrhythmias occurred during the study.
  
  
  CONCLUSIONS
  Ramosetron was not associated with prolongation of the QTc interval when it was given concomitantly with sevoflurane in children. No ventricular arrhythmias or other adverse effects occurred during the study.
authors.affiliation: From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Yoo
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Song
authors.forename: Jin-Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Kim
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000932:Antiemetics / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D011446:Prospective Studies; D000077149:Sevoflurane; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D001562:Benzimidazoles; D008738:Methyl Ethers; D000077149:Sevoflurane; C071315:ramosetron