title: Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome.
abstract: Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Polwarth Building, Aberdeen, AB25 2ZD, Scotland, UK.
authors.forename: Satnam
authors.initials: S
authors.lastname: Singh
authors.forename: Roger
authors.initials: R
authors.lastname: Beadle
authors.forename: Donnie
authors.initials: D
authors.lastname: Cameron
authors.forename: Amelia
authors.initials: A
authors.lastname: Rudd
authors.forename: Maggie
authors.initials: M
authors.lastname: Bruce
authors.forename: Baljit
authors.initials: B
authors.lastname: Jagpal
authors.forename: Konstantin
authors.initials: K
authors.lastname: Schwarz
authors.forename: Gemma
authors.initials: G
authors.lastname: Brindley
authors.forename: Fergus
authors.initials: F
authors.lastname: Mckiddie
authors.forename: Peter
authors.initials: P
authors.lastname: Nightingale
authors.forename: Chim
authors.initials: C
authors.lastname: Lang
authors.forename: Dana
authors.initials: D
authors.lastname: Dawson
authors.forename: Michael
authors.initials: M
authors.lastname: Frenneaux
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002985:Clinical Protocols; D004311:Double-Blind Method; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D017063:Outcome Assessment, Health Care; D010480:Perhexiline / Q000627:therapeutic use*; D013318:Stroke Volume / Q000502:physiology*; D013577:Syndrome
chemical_list: D002317:Cardiovascular Agents; D010480:Perhexiline
keywords: cardiac spectroscopy; diastole; ejection fraction; heart failure; perhexiline