title: High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study.
abstract: OBJECTIVE
  Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men.
  
  
  METHODS
  The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n = 1010; median age 75.3 years, range 69-81).
  
  
  METHODS
  We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition, erythropoietin (EPO), total oestradiol, leptin, cystatin C and iron and B vitamin status].
  
  
  RESULTS
  In these elderly men, age was negatively associated with Hb (r = -0.12, P < 0.001) and positively associated with adiponectin level (r = 0.13, P < 0.001). In age-adjusted partial correlations, Hb and adiponectin levels were negatively correlated (r = -0.20, P < 0.001); this association remained significant after multivariable adjustment for age, body composition, EPO, fasting insulin, sex hormones, leptin and ferritin. Age-adjusted mean adiponectin concentrations were significantly higher in anaemic men (66/1005; Hb <130 g L(-1) ) compared to nonanaemic men (14.0 vs. 11.7 μg mL(-1) , P < 0.05). In multivariate analysis, adiponectin together with EPO, total oestradiol, insulin, albumin, transferrin saturation, HDL cholesterol, cystatin C, total body fat mass and free thyroxine, but not leptin, explained 35% of the variation in Hb level. These results remained essentially unchanged after exclusion of men with diabetes.
  
  
  CONCLUSIONS
  Serum adiponectin, but not leptin, was negatively and independently associated with Hb. This finding suggests a possible role of adiponectin in the age-related decline in Hb level observed in apparently healthy elderly men.
authors.affiliation: Section of Haematology and Coagulation, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Lewerin
authors.affiliation: Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Johansson
authors.affiliation: Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.|Molecular Peridontology, Umeå University, Umeå, Sweden.
authors.forename: U H
authors.initials: UH
authors.lastname: Lerner
authors.affiliation: Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Malmö, Sweden.
authors.forename: M K
authors.initials: MK
authors.lastname: Karlsson
authors.affiliation: Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lorentzon
authors.affiliation: Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Barrett-Connor
authors.affiliation: Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Smith
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Center for Bone and Arthritis Research (CBAR), Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Ohlsson
authors.affiliation: Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Mellström
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000740:Anemia / Q000097:blood; D001823:Body Composition; D004921:Erythropoietin / Q000097:blood; D004958:Estradiol / Q000097:blood; D005293:Ferritins / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D013831:Thiamine / Q000097:blood
chemical_list: D052242:Adiponectin; D012739:Gonadal Steroid Hormones; D006454:Hemoglobins; D007328:Insulin; D020738:Leptin; D004921:Erythropoietin; D004958:Estradiol; D005293:Ferritins; D013831:Thiamine
keywords: adiponectin; ageing; anaemia; haemoglobin; men