title: Pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis?
abstract: The liver involvement in alcoholic liver disease (ALD) classically ranges from alcoholic steatosis, alcoholic hepatitis or steatohepatitis, alcoholic cirrhosis and even hepatocellular carcinoma. The more commonly seen histologic features include macrovesicular steatosis, neutrophilic lobular inflammation, ballooning degeneration, Mallory-Denk bodies, portal and pericellular fibrosis. Nonalcoholic steatohepatitis (NASH) is a condition with similar histology in the absence of a history of alcohol intake. Although the distinction is essentially based on presence or absence of a history of significant alcohol intake, certain histologic features favour one or the other diagnosis. This review aims at describing the histologic spectrum of alcoholic liver disease and at highlighting the histologic differences between ALD and NASH.
authors.affiliation: Puja Sakhuja, Department of Pathology, GB Pant Hospital, New Delhi 110002, India.
authors.forename: Puja
authors.initials: P
authors.lastname: Sakhuja
mesh_terms: D000818:Animals; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000473:pathology*; D008108:Liver Diseases, Alcoholic / Q000473:pathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
keywords: Alcoholic liver disease; Cirrhosis; Fibrosis; Hepatocellular carcinoma; Non-alcoholic steatohepatitis; Steatohepatitis; Steatosis