title: The long-term outcomes of induction chemoradiotherapy followed by surgery for locally advanced non-small cell lung cancer.
abstract: BACKGROUND
  Although the concept of induction therapy followed by surgical resection for locally advanced non-small cell lung cancer (LA-NSCLC) has found general acceptance, the appropriate indications and the strategy for this treatment are still controversial.
  
  
  METHODS
  From 2000 through 2008, 36 patients received concurrent chemoradiotherapy followed by surgery. We retrospectively reviewed these cases, analyzed the outcomes and examined the prognosis.
  
  
  RESULTS
  The median radiation dose given was 60 Gy. Chemotherapy included a platinum agent in all cases; cisplatin-based chemotherapy was administered to 9 cases, and a carboplatin-based chemotherapy regimen was administered to 27. A complete resection was performed in 94% of the patients. Seventeen (47.2%) patients exhibited a complete pathological response, and downstaging was induced in 26 (72%) cases. The morbidity and 30-day mortality rates were 11.1 and 0%, respectively. The 5-year overall survival rate in the patients with complete resection (n = 33) was 83.3%.
  
  
  CONCLUSIONS
  Induction chemoradiotherapy followed by surgery for LA-NSCLC provided a favorable prognosis for selected patients. A complete pathological response was found in about half of cases. This strategy is feasible and was associated with low morbidity and high resectability rates, suggesting that it contributed to improving the treatment results.
authors.affiliation: Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Uramoto
authors.affiliation: Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Akiyama
authors.affiliation: Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kinoshita
authors.affiliation: Division of Thoracic Surgery, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Division of Thoracic Oncology, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Kurimoto
authors.affiliation: Department of Pathology, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Nishimura
authors.affiliation: Department of Radiation Oncology, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Division of Thoracic Oncology, Saitama Cancer Center, Saitama, Hidaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakai
authors.affiliation: Department of Respiratory Medicine, Saitama International Medical Center, Hidaka, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kobayashi
keywords: Induction chemotherapy; Locally advanced non-small cell lung cancer; Non-small cell lung cancer; Prognosis; Surgical resection