title: Modulation of the effects of the cannabinoid agonist, ACPA, on spatial and non-spatial novelty detection in mice by dopamine D1 receptor drugs infused into the basolateral amygdala.
abstract: OBJECTIVE
  The amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes. This study investigates the effect of basolateral amygdale (BLA) dopamine receptors on spatial and non-spatial novelty detection deficit, induced by a selective CB1 cannabinoid receptor agonist (Arachidonylcyclopropylamide; ACPA), during a non-associative task.
  
  
  METHODS
  Male mice weighing 30-35 g were used. Open field procedure was employed to assess the spatial and non-spatial memory retention.
  
  
  RESULTS
  Our data showed that post-training intraperitoneal injection of ACPA (0.02 mg/kg), intra-BLA microinjection of SKF38393 (D1 dopamine receptor agonist; at higher dose, 0.1 μg/mouse) and SCH23390 (D1 dopamine receptor antagonist; at lowest dose, 0.005 μg/mouse) impaired both spatial and non-spatial novelty detection. Moreover, intra-BLA microinjection of subthreshold dose of SKF38393 or SCH23390 restored and potentiated the spatial and non-spatial novelty detection impairment caused by ACPA, respectively.
  
  
  CONCLUSIONS
  Our results suggested that the ACPA induced impairment of memory retention, may occur through BLA D1 dopamine receptors.
authors.affiliation: Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
authors.forename: Meisam
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Medical Genomics Research Centerand School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran. Electronic address: Nasehi@iricss.org.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nasehi
authors.affiliation: Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Zarrindast
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D066272:Basolateral Nuclear Complex / Q000187:drug effects* / Q000502:physiology; D001552:Benzazepines / Q000494:pharmacology; D063386:Cannabinoid Receptor Agonists / Q000494:pharmacology*; D002408:Catheters, Indwelling; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D001552:Benzazepines; D063386:Cannabinoid Receptor Agonists; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; C119324:arachidonylcyclopropylamide; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
keywords: Amygdala; CB1 cannabinoid receptor; Dopamine D1 receptor; Spatial memory