title: Two new N-oxide alkaloids from Stemona cochinchinensis.
abstract: Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the 1H- and 13C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. ligenl@umac.mo.
authors.forename: Ligen
authors.initials: L
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. mb45828@umac.mo.
authors.forename: Han
authors.initials: H
authors.lastname: Bao
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. yb37510@umac.mo.
authors.forename: Anqi
authors.initials: A
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. tangcp_sh@163.com.
authors.forename: Chunping
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Hanoi National University of Education, Hanoi 100000, Vietnam. dienph@hnue.edu.vn.
authors.forename: Pham-Huu
authors.initials: PH
authors.lastname: Dien
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. yye@mail.shcnc.ac.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010087:Oxides; D010936:Plant Extracts / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010087:Oxides; D010936:Plant Extracts