title: Imbalanced splicing in MAPK signaling sustains Ras-induced transformation.
abstract: Increasingly, evidence suggests that phosphorylation of the mRNA translation initiation factor eIF4E plays an important role in carcinogenesis, downstream of Ras. The eIF4E factor is phosphorylated by MAPK-interacting protein kinases 1 and 2 (MNK1 and MNK2). Due to alternative splicing, two MNK2 proteins exist (MNK2a and MNK2b). While MNK2a possesses a binding site for the stress-induced p38-MAPK, MNK2b does not. Recently, Maimon et al. revealed that a splicing shift towards the MNK2b isoform, in Ras-activated cells, sustains transformation, due to a defect in p38-induced cell death, while the MNK2b-dependent phosphorylation of eIF4E is maintained.
authors.affiliation: Inserm UMR-1037, Laboratoire d'excellence Toulouse Cancer: TOUCAN, Équipe labellisée ligue contre le cancer, Université de Toulouse, 31432 Toulouse, France.
authors.forename: David
authors.initials: D
authors.lastname: Müller
authors.affiliation: Inserm UMR-1037, Laboratoire d'excellence Toulouse Cancer: TOUCAN, Équipe labellisée ligue contre le cancer, Université de Toulouse, 31432 Toulouse, France.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Martineau
authors.affiliation: Inserm UMR-1037, Laboratoire d'excellence Toulouse Cancer: TOUCAN, Équipe labellisée ligue contre le cancer, Université de Toulouse, 31432 Toulouse, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Bousquet
authors.affiliation: Inserm UMR-1037, Laboratoire d'excellence Toulouse Cancer: TOUCAN, Équipe labellisée ligue contre le cancer, Université de Toulouse, 31432 Toulouse, France. Electronic address: stephane.pyronnet@inserm.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pyronnet
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D017346:Protein Serine-Threonine Kinases; D048051:p38 Mitogen-Activated Protein Kinases