title: Highly selective and sensitive 1-amino BODIPY-based red fluorescent probe for thiophenols with high off-to-on contrast ratio.
abstract: A highly selective and sensitive turn-on red fluorescent 1-amino BODIPY-based probe (where BODIPY denotes indole-based boron-dipyrromethene) with high off-to-on contrast ratio has been developed. The probe displayed selective response to thiophenols over aliphatic thiols. Probe 1 is promising for the quantitative detection of thiophenol with a linear response from 6 × 10(-6) M to 1 × 10(-4) M, and the detection limit for thiophenol (PhSH) reaches 4 × 10(-6) M measured in acetonitrile/PBS buffer. The detection limit could be improved to 37 nM (detection limit to 4 ppb) in water when 1% Tween 20 was used to assist the dissolvation of probe 1 in water. Probe 1 is also a useful fluorescent probe for detecting thiophenols in living cells in red emission, which may greatly improve the detectable sensitivity.
authors.affiliation: Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University , Kaifeng, 475004, People's Republic of China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Shao
authors.forename: Ruixue
authors.initials: R
authors.lastname: Kang
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhentao
authors.initials: Z
authors.lastname: Huang
authors.forename: Fangfang
authors.initials: F
authors.lastname: Peng
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Fuchao
authors.initials: F
authors.lastname: Pan
authors.forename: Weijuan
authors.initials: W
authors.lastname: Zhang
authors.forename: Weili
authors.initials: W
authors.lastname: Zhao
mesh_terms: D001896:Boron Compounds / Q000737:chemistry; D006528:Carcinoma, Hepatocellular; D003287:Contrast Media / Q000737:chemistry; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted; D057230:Limit of Detection; D008113:Liver Neoplasms; D008856:Microscopy, Fluorescence; D010636:Phenols / Q000032:analysis*; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000032:analysis*; D014407:Tumor Cells, Cultured
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D003287:Contrast Media; D005456:Fluorescent Dyes; D010636:Phenols; D013438:Sulfhydryl Compounds; C042983:thiophenol