title: [Efficacy of Venarus in treatment of patients with post-thrombotic disease of lower limbs].
abstract: The authors studied efficacy of Venarus in comprehensive treatment of patients presenting with post-thrombotic disease. An open multicenter retrospective study included a total of 110 patients subdivided into two groups. Group One (Study Group) consisted of 51 patients with post-thrombotic syndrome, undergoing comprehensive medical treatment with the use of phlebotonic agent Venarus. Group Two (Control Group) comprised 59 patients with post-thrombotic syndrome undergoing similar conservative treatment but without taking phlebotonics. It was proved that Venarus included into comprehensive treatment of patients with post-thrombotic syndrome led to a statistically significant increase of both psychological and social activity and improved patients' quality of life. During the standard term of administration (2 months) Venarus levelled subjective symptoms and certain objective symptoms (according to the Villalta Scale) of post-thrombotic syndrome. After 2-month use Venarus demonstrated the highest efficacy in treating patients with mild-to-moderate post-thrombotic syndrome. The maximal efficacy was observed after 3 months of administration in standard doses. No side effects were noted during the whole period of the study.
authors.forename: I N
authors.initials: IN
authors.lastname: Son'kin
authors.forename: E V
authors.initials: EV
authors.lastname: Shaĭdakov
authors.forename: D V
authors.initials: DV
authors.lastname: Krylov
authors.forename: V L
authors.initials: VL
authors.lastname: Bulatov
authors.forename: A S
authors.initials: AS
authors.lastname: Remizov
authors.forename: M V
authors.initials: MV
authors.lastname: Rezvantsev
mesh_terms: D058128:Compression Bandages; D004145:Diosmin / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D016903:Drug Monitoring; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000009:adverse effects; D006569:Hesperidin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D054070:Postthrombotic Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications*
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; D004145:Diosmin; D006569:Hesperidin