title: Electroanalysis of antitubercular drugs in pharmaceutical dosage forms and biological fluids: a review.
abstract: Tuberculosis remains a major global public health problem. Given the need for extensive analysis of antitubercular drugs, the development of sensitive, reliable and facile analytical methods to determine these compounds becomes necessary. Electrochemical techniques have inherent advantages over other well-established analytical methods, this review aiming to provide an updated overview of the latest trends (from 2006 till date) in the voltammetric determination of antitubercular drugs. Furthermore, the advantages and limitations of these methods are critically discussed. The review reveals that in spite of using a variety of chemically modified electrodes to determine antitubercular drugs, there is still a dearth of applicability of the voltammetric methods to quantify these compounds in human body fluids, especially in blood plasma.
authors.affiliation: Department of Pharmaceutical, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
authors.forename: Neeta
authors.initials: N
authors.lastname: Thapliyal
authors.affiliation: Department of Pharmaceutical, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
authors.forename: Rajshekhar V
authors.initials: RV
authors.lastname: Karpoormath
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. Electronic address: rngcyfcy@iitr.ac.in.
authors.forename: Rajendra N
authors.initials: RN
authors.lastname: Goyal
mesh_terms: D000995:Antitubercular Agents / Q000032:analysis* / Q000097:blood; D001826:Body Fluids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D055664:Electrochemical Techniques; D006801:Humans; D013058:Mass Spectrometry; D013607:Tablets / Q000737:chemistry
chemical_list: D000995:Antitubercular Agents; D013607:Tablets
keywords: Antitubercular drugs; Human body fluids; Pharmaceutical formulations; Tuberculosis; Voltammetry