title: The nucleolus gets the silent treatment.
abstract: In this issue of Cell Stem Cell, Savić et al. (2014) and Kim et al. (2014) provide insight into how global heterochromatin condensation and LIN28 sequestration in embryonic stem cells are independent mechanisms regulating pluripotency in the oft-overlooked nucleolus.
authors.affiliation: Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: afeinberg@jhu.edu.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Feinberg
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D053595:Embryonic Stem Cells / Q000502:physiology*; D020459:Genes, rRNA; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D062085:RNA, Long Noncoding / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins