title: Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection.
abstract: Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI(™)) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.
authors.affiliation: Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Guinan
authors.affiliation: Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Ronci
authors.affiliation: Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Vasani
authors.affiliation: School of Physical and Chemical Sciences, Flinders University, Bedford Park, SA 5042, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Kobus
authors.affiliation: Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia. Electronic address: nico.voelcker@unisa.edu.au.
authors.forename: N H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D000662:Amphetamines / Q000302:isolation & purification*; D001569:Benzodiazepines / Q000302:isolation & purification*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D053610:Opiate Alkaloids / Q000302:isolation & purification*; D016062:Porosity; D012463:Saliva / Q000737:chemistry; D012680:Sensitivity and Specificity; D012825:Silicon / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D015813:Substance Abuse Detection / Q000295:instrumentation* / Q000379:methods; D014326:Tropanes / Q000302:isolation & purification*
chemical_list: D000662:Amphetamines; D053610:Opiate Alkaloids; D014326:Tropanes; D001569:Benzodiazepines; D012825:Silicon
keywords: DIOS; Drug detection; NALDI(™); NIMS; SALDI