title: Neuroimaging and genetic influence in treating brain neoplasms.
abstract: The current treatment of glioblastoma patients based on surgery, radiation, and chemotherapy has achieved modest improvement in progression-free survival. In this direction, personalized treatment is the next achievement for better patient management and increased overall survival. Genetic characterization of high-grade gliomas by MR imaging is the goal in neuroimaging. The main genetic alterations described in these neoplasms, implications in patient treatment, and prognosis are reviewed. MR imaging features and novel techniques are correlated with the main genetic aspects of such tumors. Posttreatment phenomena, such as pseudoprogression and pseudoresponse, are analyzed in association with the genetic expression of these tumors.
authors.affiliation: MRI Department of Clínica de Diagnostico por Imagem (CDPI) and IRM Ressonância Magnética, Av. das Américas, 4666 Sl 325, Centro Médico Barrashopping, Rio de Janeiro, RJ, Brazil. Electronic address: celsohygino@hotmail.com.
authors.forename: L Celso
authors.initials: LC
authors.lastname: Hygino da Cruz
authors.affiliation: MRI Department of Clínica de Diagnostico por Imagem (CDPI), Av. das Américas, 4666 Sl 325, Centro Médico Barrashopping, Rio de Janeiro, RJ, Brazil.
authors.forename: Margareth
authors.initials: M
authors.lastname: Kimura
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D023281:Genomics / Q000379:methods*; D005909:Glioblastoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods*
keywords: Gene expression; Glioblastoma; High-grade gliomas; Outcome; Prognosis; Pseudoprogression; Radiogenomic; Treatment response