title: Adaptation to physical training in rats orally supplemented with glycerol.
abstract: We evaluated training adaptation and physical performance parameters in rats orally supplemented with glycerol, glucose, or saline, and submitted to moderate aerobic exercise. Thirty male rats were trained for 6 weeks and administered the supplements during the last 4 weeks of the experiment. Animals were distributed in a completely randomized factorial 2 × 3 design (with or without exercise and 3 substrates). Data were subjected to analysis of variance (ANOVA) and means were compared using the Student-Newmann-Keuls test at 5%. Among the trained animals, none of the substances caused differences in the percentages of protein, fat, or water content in the carcass. Compared with the sedentary animals, the trained animals supplemented with saline and glucose showed a higher protein percentage in the carcass. The relative mass of the heart and adrenal glands was higher in the trained animals. Glycerol improved the protein content in non-trained animals and increased the relative adrenal mass in both groups. Glycerol reduced the variation in levels of lactate and aspartate aminotransferase (AST) during the last exercise session. There was no difference between groups regarding the relative mass of the thymus and gastrocnemius or with the diameter of muscle fibers or the neutrophil-lymphocyte ratio. Supplementation with glycerol was efficient at attenuating variation in AST and lactate levels during exercise.
authors.affiliation: a Department of Veterinary Medicine, Federal University of Lavras, 37200-000 Lavras, Brazil.
authors.forename: Eric Francelino
authors.initials: EF
authors.lastname: Andrade
authors.forename: Raquel Vieira
authors.initials: RV
authors.lastname: Lobato
authors.forename: Ticiana Vasques
authors.initials: TV
authors.lastname: de Araújo
authors.forename: Débora Ribeiro
authors.initials: DR
authors.lastname: Orlando
authors.forename: Diego
authors.initials: D
authors.lastname: Vicente da Costa
authors.forename: Víviam
authors.initials: V
authors.lastname: de Oliveira Silva
authors.forename: Gustavo Puggina
authors.initials: GP
authors.lastname: Rogatto
authors.forename: Márcio Gilberto
authors.initials: MG
authors.lastname: Zangeronimo
authors.forename: Priscila Vieira
authors.initials: PV
authors.lastname: Rosa
authors.forename: Luciano José
authors.initials: LJ
authors.lastname: Pereira
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology*; D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D005990:Glycerol / Q000008:administration & dosage*; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005990:Glycerol
keywords: activité physique; athletes; athlètes; glycerin; glycérine; hyper-hydration; hyperhydratation; nutrition; physical activity