title: Meta-analysis of quantitative diffusion-weighted MR imaging in differentiating benign and malignant pancreatic masses.
abstract: There have been numerous studies done to explore the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging to differentiate between benign and malignant pancreatic masses. However, the results have been inconsistent. We performed a meta-analysis to investigate whether DW-MR imaging can differentiate between these two diseases. Databases including MEDLINE, EMBASE and Cochrane Library were utilized to find relevant articles published between January 2001 and January 2014. A Stata version 12.0 and a Meta-Disc version 1.4 were used to describe primary results. Twelve studies with 594 patients, which fulfilled the inclusion criteria, were enrolled for the analysis. The pooled sensitivity and specificity of DW imaging was 0.91 (95% CI: 0.84, 0.95) and 0.86 (95% CI: 0.76, 0.93) respectively. The area under the curve of the summary receiver operating characteristic was 0.95 (95% CI: 0.93, 0.96). The results indicated that DW imaging might be a valuable tool for differentiating benign and malignant pancreatic masses.
authors.affiliation: Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu, 610000, China.
authors.forename: Xiang-Ke
authors.initials: XK
authors.lastname: Niu
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Anup
authors.initials: A
authors.lastname: Bhetuwal
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Sushant
authors.initials: S
authors.lastname: Das
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Ying-Quan
authors.initials: YQ
authors.lastname: Xiao
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Li-Chuan
authors.initials: LC
authors.lastname: Zeng
authors.affiliation: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China. niu19850519@163.com.
authors.forename: Han-Feng
authors.initials: HF
authors.lastname: Yang
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D016239:MEDLINE; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D011859:Radiography; D012680:Sensitivity and Specificity