title: Late outcomes after arterial switch operation for Taussig-Bing anomaly.
abstract: OBJECTIVE
  To assess the long-term results of the arterial switch operation (ASO) for Taussig-Bing Anomaly (TBA) and identify risk factors affecting outcomes.
  
  
  METHODS
  Retrospective review and late follow-up was performed for all TBA patients from 1997 to 2010 (follow-up >3 years). Selection criteria included the absence of mitro-pulmonary continuity.
  
  
  RESULTS
  Sixty-nine children underwent ASO at a median age of 24 days (interquartile range [IR] 11-125), with concomitant repair of aortic arch obstruction in 26 (37.7%). Complex coronary anatomy (n = 38; 55.0%) was common. Nine (13.0%) patients had staged repair. Hospital mortality was 5.8% (95% confidence interval [CI], 1.6%-14.2%; n = 4). Median follow-up was 11.2 years (IR 7.2-13.8). Subsequent mortality was confined to the first postoperative year (n = 5, 86% [95% CI, 78%-95%]), 1-, and 10-year survival). Overall mortality was related to coronary pattern (Yacoub types C and E vs A and D, multivariate, hazard ratio [HR] 12.2 [95% CI, 1.2-122.1], P = .03). At latest follow-up, 96% of the survivors are asymptomatic, with normal ventricular function. Cumulative incidence of reintervention at 10 years was 53% (95% CI, 28%-77%). Concomitant aortic arch obstruction was a predictor of reintervention (multivariate, HR 2.9 [95% CI, 1.1-7.4], P = .03). No mortality occurred upon reinterventions.
  
  
  CONCLUSIONS
  In the largest series to date of ASO for TBA, mortality is confined to the first postoperative year, and related to coronary artery pattern. Beyond the first year, needed reinterventions are frequent, but with sustained functional status and no mortality over >10 years follow-up. Aortic arch obstruction is the main predictor for reintervention. Despite a significant rate of early events, favorable long-term outcomes argue for use of the ASO in TBA patients.
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France. Electronic address: mvergnat@gmail.com.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Vergnat
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France; School of Medicine Paris-South, University Paris-South, Le Kremlin-Bicêtre, France.
authors.forename: Alban-Elouen
authors.initials: AE
authors.lastname: Baruteau
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France.
authors.forename: Lucile
authors.initials: L
authors.lastname: Houyel
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France.
authors.forename: Mohamedou
authors.initials: M
authors.lastname: Ly
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France.
authors.forename: Régine
authors.initials: R
authors.lastname: Roussin
authors.affiliation: School of Medicine Paris-South, University Paris-South, Le Kremlin-Bicêtre, France; INSERM U999, Marie-Lannelongue Hospital, Le Plessis Robinson, France.
authors.forename: André
authors.initials: A
authors.lastname: Capderou
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France; INSERM U999, Marie-Lannelongue Hospital, Le Plessis Robinson, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Lambert
authors.affiliation: Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France.
authors.forename: Emre
authors.initials: E
authors.lastname: Belli
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D004310:Double Outlet Right Ventricle / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000401:mortality / Q000628:therapy; D016016:Proportional Hazards Models; D019233:Retreatment; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome