title: Immunocompetent mouse models to evaluate intrahepatic T cell responses to HCV vaccines.
abstract: Despite considerable progress in the development of immunocompetent mouse models using different high end technologies, most available small animal models for HCV study are unsuitable for challenge experiments, which are vital for vaccine development, as they fail to measure the T cell response in liver. A recently developed intra-hepatic challenge model results in HCV antigen expression in mouse hepatocytes and through the detection of the surrogate marker, SEAP, in serum, the effect of prior vaccination can be monitored longitudinally.
authors.affiliation: a Discipline of Surgery ; University of Adelaide; Basil Hetzel Institute ; Adelaide , SA , Australia.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Yu
authors.forename: Branka
authors.initials: B
authors.lastname: Grubor-Bauk
authors.forename: Ranajoy
authors.initials: R
authors.lastname: Mullick
authors.forename: Saumitra
authors.initials: S
authors.lastname: Das
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Gowans
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007111:Immunity, Cellular; D008099:Liver / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D014761:Viral Hepatitis Vaccines
keywords: C virus; Hepatitis HCV Vaccine; Rag 2, Recombination activating gene 2; SCID, severe combined immunodeficiency; SEAP, secreted alkaline phosphatase; mouse challenge models; uPA, urokinase-type plasminogen activator