title: Investigation on artificial blood vessels prepared from bacterial cellulose.
abstract: BC (bacterial cellulose) exhibits quite distinctive properties than plant cellulose. The outstanding properties make BC a promising material for preparation of artificial blood vessel. By taking advantage of the high oxygen permeability of PDMS (polydimethylsiloxane) as a tubular template material, a series of BC tubes with a length of 100 mm, a thickness of 1mm and an outer diameter of 4 or 6mm were biosynthesized with the help of Gluconacetobacter xylinum. Through characterization by SEM (scanning electron microscope), tensile testing and thermal analysis, it is demonstrated that BC tubes are good enough for artificial blood vessel with elaborated nano-fiber architecture, qualified mechanical properties and high thermal stability. In addition, measurement of biocompatibility also shows that BC tubes are greatly adaptable to the in vivo environment. The results indicate that BC tubes have great potential for being utilized as tubular scaffold materials in the field of tissue engineering.
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zang
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Jianhai
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chang
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Guixing
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: yang_sunny@yahoo.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001808:Blood Vessels / Q000502:physiology*; D002448:Cell Adhesion; D002470:Cell Survival; D002482:Cellulose / Q000737:chemistry*; D004129:Dimethylpolysiloxanes; D041822:Gluconacetobacter xylinus / Q000737:chemistry; D006461:Hemolysis; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D008422:Materials Testing; D051379:Mice; D008810:Mice, Inbred C57BL; D008955:Models, Cardiovascular; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; C013830:baysilon; D002482:Cellulose
keywords: Bacterial cellulose; Biocompatibility; Cell adhesion; PDMS