title: Gold-phosphine-porphyrin as potential metal-based theranostics.
abstract: Two new gold-phosphine-porphyrin derivatives were synthesized and fully characterized, and their photophysical properties investigated along a water-soluble analog. The cytotoxicity of the compounds was tested on cancer cells (HCT116 and SW480), and their cell uptake was followed by fluorescence microscopy in vitro (on SW480). The proof that the water-soluble gold-phosphine-porphyrin is a biologically active compound that can be tracked in vitro was clearly established, especially concerning the water-soluble analog. Some preliminary photodynamic therapy (PDT) experiments were also performed. They highlight a dramatic increase of the cytotoxicity when the cells were illuminated for 30 min with white light.
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France.
authors.forename: Semra
authors.initials: S
authors.lastname: Tasan
authors.affiliation: Unité 1113 INSERM, «Signalisation moléculaire du stress cellulaire et pathologies», Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Licona
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Doulain
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Michelin
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France. claude.gros@u-bourgogne.fr.
authors.forename: Claude P
authors.initials: CP
authors.lastname: Gros
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Le Gendre
authors.affiliation: Département de Chimie, Université de Sherbrooke, Sherbrooke, JIK 2R1, QC, Canada.
authors.forename: Pierre D
authors.initials: PD
authors.lastname: Harvey
authors.affiliation: EPHE Cancer Immunotherapy Laboratory, 21000, Dijon, France.|EA7269 EPHE-University of Burgundy, 21000, Dijon, France.|University of Burgundy, 21000, Dijon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Paul
authors.affiliation: Unité 1113 INSERM, «Signalisation moléculaire du stress cellulaire et pathologies», Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Gaiddon
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 Avenue A. Savary, BP 47870, 21078, Dijon, France. Ewen.Bodio@u-bourgogne.fr.
authors.forename: Ewen
authors.initials: E
authors.lastname: Bodio
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D010720:Phosphines / Q000737:chemistry* / Q000494:pharmacology; D010778:Photochemotherapy; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D056831:Coordination Complexes; D010720:Phosphines; D011166:Porphyrins; D006046:Gold