title: American Recovery and Reinvestment Act investments in data infrastructure.
abstract: OBJECTIVE
  This article describes American Reinvestment and Recovery Act comparative effectiveness research data infrastructure (DI) investments and identifies facilitators and barriers to implementation.
  
  
  METHODS
  We reviewed original project proposals, conducted an investigator survey and interviewed project officers and principal investigators.
  
  
  RESULTS
  DI projects assembled or enhanced existing clinical datasets, established linkages between public and private data sources and built infrastructure. Facilitators included building on existing relationships across organizations and making collection as seamless as possible for clinicians.
  
  
  CONCLUSIONS
  To sustain DI, investigators should reduce the burden of comparative effectiveness research data collection on practices, adequately address data privacy and security issues, resolve or lessen the impact of data-linking issues and build research capacity for other investigators and clinicians.
authors.affiliation: Mathematica Policy Research, 1100 First Street NE, Suite 1200, Washington, DC 20002, USA.
authors.forename: Bonnie
authors.initials: B
authors.lastname: O'Day
authors.forename: Tessa
authors.initials: T
authors.lastname: Kieffer
authors.forename: Sarah
authors.initials: S
authors.lastname: Forrestal
authors.forename: Dominick
authors.initials: D
authors.lastname: Esposito
mesh_terms: D057171:American Recovery and Reinvestment Act / Q000191:economics*; D057186:Comparative Effectiveness Research / Q000191:economics*; D016494:Computer Security; D003625:Data Collection / Q000191:economics*; D005380:Financing, Government / Q000191:economics*; D006040:Goals; D007400:Interprofessional Relations; D012107:Research Design; D012108:Research Personnel; D014481:United States
keywords: ARRA; American Recovery and Reinvestment Act; CER; comparative effectiveness research; data infrastructure