title: Acceleration of small bowel transit in a canine hypermotility model with intestinal electrical stimulation.
abstract: OBJECTIVE
  Few studies have been performed on the effect of intestinal electrical stimulation (IES) on intestinal dysmotility. This study aimed to investigate the small intestine transit (SIT) in a canine model of intestinal hypermotility when applying IES.
  
  
  METHODS
  Six hound bitches were surgically prepared with two chronic intestinal fistulas, intestinal serosal electrodes of which the proximal pair was used for serosal IES. Pacing wires were attached to a manometric catheter for mucosal IES. A nitrogen oxide synthase inhibitor, Nω-nitro-L-arginine (LNNA) was used to induce intestinal motility. SIT was measured during IES. The study consisted of four randomized sessions: session 1 (LNNA), session 2 (LNNA plus serosal IES), session 3 (LNNA plus mucosal IES) and session 4 (control).
  
  
  RESULTS
  The intestine transit was slowed down from 31.7 ± 6.1 min in the control session to 49.0 ± 6.2 min after using LNNA (P = 0.003). Both mucosal and serosal IES accelerated SIT compared with the LNNA session. The SIT time was reduced to 17.7 ± 3.4 min in the mucosal IES session (P = 0.006 vs. LNNA) and 27.5 ± 6.3 min in the serosal IES session (P = 0.020 vs. LNNA). No difference was noted in the SIT time between mucosal and serosal IES (P = 0.128).
  
  
  CONCLUSIONS
  IES significantly accelerates delayed SIT in a hypermotility model and intraluminal stimulation is as effective as a serosal one for IES, suggesting that IES may have a therapeutic potential for improving intestinal motility.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Wei Feng
authors.initials: WF
authors.lastname: Wang
authors.forename: Jie Yun
authors.initials: JY
authors.lastname: Yin
authors.forename: Jian
authors.initials: J
authors.lastname: De Dz Chen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D005767:Gastrointestinal Diseases / Q000503:physiopathology / Q000628:therapy*; D005769:Gastrointestinal Motility / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D007421:Intestine, Small / Q000503:physiopathology*; D008365:Manometry / Q000379:methods; D009119:Muscle Contraction / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology
keywords: hypermotility; intestinal electrical stimulation; small intestine transit