title: Influence of the GPX1 gene polymorphism to aerobic capacity and efficiency of glutathione supplementation in athletes.
abstract: The aim was to investigate compare genotype and allele frequencies of the GPX1 gene Pro198Leu polymorphism in 736 Russian athletes and 564 non-athletic controls. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). Also, we investigated whether glutathione had antioxidant effects in runners. Runners of the experimental group 1 (16 persons) unlike the group 2 (16 persons) had been administered 600 mg of glutathione sodium intramuscularly after trainings daily, during 14 days. The best response to glutathione was presented by the GPX1 Pro allele.
authors.forename: A D
authors.initials: AD
authors.lastname: Lifanov
authors.forename: M N
authors.initials: MN
authors.lastname: Khadyeva
authors.forename: L Sh
authors.initials: LSh
authors.lastname: Rakhmatullina
authors.forename: S V
authors.initials: SV
authors.lastname: Demenev
authors.forename: G F
authors.initials: GF
authors.lastname: Khamidullina
authors.forename: A M
authors.initials: AM
authors.lastname: Chekulaeva
authors.forename: E M
authors.initials: EM
authors.lastname: Sofronova
mesh_terms: D000328:Adult; D000483:Alleles; D000975:Antioxidants / Q000008:administration & dosage*; D056352:Athletes; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D005978:Glutathione / Q000008:administration & dosage*; D005979:Glutathione Peroxidase / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007273:Injections, Intramuscular; D007930:Leucine / Q000235:genetics; D008297:Male; D010101:Oxygen Consumption / Q000235:genetics*; D010807:Physical Endurance / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011392:Proline / Q000235:genetics; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D011392:Proline; D005979:Glutathione Peroxidase; D005978:Glutathione; D007930:Leucine; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human