title: New insights into the mechanisms of acute kidney injury in the intensive care unit.
abstract: Acute kidney injury is a frequent complication in the intensive care unit that is associated with increased mortality and morbidity. Traditional models consider reductions of global renal blood flow as the cause of acute kidney injury. However, a complex interplay between ischemia-reperfusion injury and inflammation may lead to intrarenal hypoperfusion and acute kidney injury. The role of changes of global renal blood flow as a cause for acute kidney injury remains controversial, especially in sepsis-induced acute kidney injury.
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Seth D
authors.initials: SD
authors.lastname: Glodowski
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: gw72@columbia.edu.
authors.forename: Gebhard
authors.initials: G
authors.lastname: Wagener
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D007362:Intensive Care Units; D007668:Kidney / Q000503:physiopathology; D012079:Renal Circulation / Q000502:physiology; D015427:Reperfusion Injury / Q000150:complications; D018805:Sepsis / Q000150:complications
keywords: Ischemia reperfusion injury; RIFLE criteria; Renal autoregulation; Renal blood flow; Sepsis; Septic AKI