title: Mediation analysis of health-related quality of life among people living with HIV infection in China.
abstract: The effects of stigma, social support, and depressive symptoms on health-related quality of life are well documented in the literature, but how these psychological factors interact with each other, and the combined effects when taken together on the health-related quality of life for people living with HIV, remain unclear. This cross-sectional study investigated 114 people living with HIV who were taking antiretroviral medication using the HIV/AIDS-related Stigma Scale (Chinese version), the Social Support Rating Scale, the Center for Epidemiological Studies Depression Scale, and the Medical Outcomes Study-HIV health survey. Multiple linear regression analyses were used to examine the mediation effect of the psychosocial factors on health-related quality of life. Results showed that stigma and social support did not have direct effects, but indirect effects on health-related quality of life through a full mediation effect of depressive symptoms. The results indicate that interventions targeting depression might be the most effective approach to improving health-related quality of life among people living with HIV who are taking antiretroviral medication in China.
authors.affiliation: Xiangya School of Nursing, Central South University, Changsha, China.
authors.forename: Xianhong
authors.initials: X
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Honghong
authors.initials: H
authors.lastname: Wang
authors.forename: Kristopher P
authors.initials: KP
authors.lastname: Fennie
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Ann Bartley
authors.initials: AB
authors.lastname: Williams
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000451:nursing / Q000523:psychology*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D057545:Social Stigma; D012944:Social Support
chemical_list: D019380:Anti-HIV Agents
keywords: China; HIV; depression; quality of life; social support; stigma