title: A systems biology approach to iron metabolism.
abstract: Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several scales, ranging from the subcellular to the organismal. This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in iron metabolism and their underlying causes.
authors.affiliation: Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Chifman
authors.forename: Reinhard
authors.initials: R
authors.lastname: Laubenbacher
authors.forename: Suzy V
authors.initials: SV
authors.lastname: Torti
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D000090463:Iron Deficiencies; D019189:Iron Metabolism Disorders / Q000235:genetics / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008954:Models, Biological; D049490:Systems Biology
chemical_list: D007501:Iron