title: Mucolipidosis type IV protein TRPML1-dependent lysosome formation.
abstract: Lysosomes are dynamic organelles that undergo cycles of fusion and fission with themselves and with other organelles. Following fusion with late endosomes to form hybrid organelles, lysosomes are reformed as discrete organelles. This lysosome reformation or formation is a poorly understood process that has not been systematically analyzed and that lacks known regulators. In this study, we quantitatively define the multiple steps of lysosome formation and identify the first regulator of this process.
authors.affiliation: Department of Molecular and Cellular Biology, Life Sciences South Room 531, University of Arizona, Tucson, AZ, 85721, USA.
authors.forename: Austin
authors.initials: A
authors.lastname: Miller
authors.forename: Jessica
authors.initials: J
authors.lastname: Schafer
authors.forename: Cameron
authors.initials: C
authors.lastname: Upchurch
authors.forename: Ellen
authors.initials: E
authors.lastname: Spooner
authors.forename: Julie
authors.initials: J
authors.lastname: Huynh
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hernandez
authors.forename: Brooke
authors.initials: B
authors.lastname: McLaughlin
authors.forename: Liam
authors.initials: L
authors.lastname: Oden
authors.forename: Hanna
authors.initials: H
authors.lastname: Fares
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D008247:Lysosomes / Q000378:metabolism* / Q000502:physiology*; D051379:Mice; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: C512321:Mcoln1 protein, mouse; D050051:Transient Receptor Potential Channels
keywords: TRPML1; lysosome; mucolipidosis type IV