title: The correlation of expression of VEGF and EGFR with SUV of (18)FDG-PET-CT in non-small cell lung cancer.
abstract: OBJECTIVE
  To explore the correlation of the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) with maximum standardised uptake value (SUVmax) of (18)FDG-PET-CT in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Thirty patients received PET-CT imaging protocol first, and then all the patients underwent needle biopsy though CT guidance. The tumour tissue of each patient was taken from two biopsy areas: one area was SUVmax = 2.5-5, and the other was SUVmax > 5. Expression of VEGF and EGFR were detected and analysed by immunohistochemical staining.
  
  
  RESULTS
  The expressions of both VEGF and EGFR had no statistically significant correlation with SUVmax in age, gender, pathology, or differentiation (p > 0.05). The expressions of both VEGF and EGFR had statistically significant correllation with SUVmax in tumour size and clinical stage (p < 0.05). SUVmax correlated positively with VEGF and EGFR expressions (r = 0.879, p < 0.05).
  
  
  CONCLUSIONS
  SUVmax correlated positively with expressions of VEGF and EGFR (r = 0.879, p = 0.000; r = 0.839, and p = 0.000, respectively). This study may provide guidance for radiotherapy of NSCLC.
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Haichao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
authors.forename: Shan-Ai
authors.initials: SA
authors.lastname: Song
keywords: non-small cell lung cancer; vascular endothelial growth factor