title: Prolactin in inflammatory response.
abstract: Prolactin (PRL) is a peptide hormone produced by the pituitary gland and diverse extrapituitary sites, which triggers activation of various signaling pathways after binding to its receptor (PRLr) resulting in the activation of specific genes associated with the pleiotropic activities of PLR. To date, various PRLr isoforms have been described, generated by post-transcriptional or post-translational processes. PRL has been associated with the modulation of a variety of actions in the immune response and inflammatory processes in several physiologic and pathologic conditions. However, PRL can have opposite effects, which might be regulated by interaction with the various isoforms of PRLR and PRL variants, as well as the cellular and molecular microenvironment influence.
authors.affiliation: Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340, Guadalajara, JAL, México.
authors.forename: Ana Laura
authors.initials: AL
authors.lastname: Pereira Suarez
authors.forename: Gonzalo
authors.initials: G
authors.lastname: López-Rincón
authors.forename: Priscila A
authors.initials: PA
authors.lastname: Martínez Neri
authors.forename: Ciro
authors.initials: C
authors.lastname: Estrada-Chávez
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology; D015213:Neuroimmunomodulation / Q000502:physiology; D009490:Neurosecretory Systems / Q000276:immunology; D011388:Prolactin / Q000502:physiology*; D011981:Receptors, Prolactin / Q000502:physiology
chemical_list: D011981:Receptors, Prolactin; D011388:Prolactin