title: Relationship between history of smoking, metabolic and inflammatory markers, parameters of body composition and muscle strength.
abstract: The objective of this study was to investigate the relationship between smoking history expressed by pack-years, metabolic and inflammatory markers, parameters of body composition (BC) and muscle strength among heavy smokers. A detailed smoking history was obtained from 49 heavy smokers (age = 44 ± 12, pack-years = 31 ± 23). Blood samples were analyzed for levels of glucose, lipids, liver enzymes and C-reactive protein (CRP). Anthropometric measurements included waist circumference and assessment of BC by dual energy X-ray absorptiometry (DEXA) and bioelectrical impedance analysis (BIA). Muscle strength was assessed by handgrip dynamometry and predicted one-repetition maximum (p1RM) tests. Positive correlations were found between pack-years of smoking, fasting glucose, alkaline phosphatase and CRP levels. Pack-years were also positively correlated with waist circumference, body mass index (BMI), whole-body and trunk fat mass measured by both DEXA and BIA. A negative correlation was found between pack-years of smoking and muscle strength measured by p1RM for the leg press exercise. After adjustment for age, sex and BMI, a positive correlation remained between pack-years of smoking and CRP levels. In conclusion, after controlling for possible confounders, smoking history was found to be positively associated with CRP levels among heavy smokers.
authors.affiliation: Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Rom
authors.forename: K
authors.initials: K
authors.lastname: Karkabi
authors.forename: A Z
authors.initials: AZ
authors.lastname: Reznick
authors.forename: Z
authors.initials: Z
authors.lastname: Keidar
authors.forename: D
authors.initials: D
authors.lastname: Aizenbud
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D001823:Body Composition / Q000187:drug effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D053581:Muscle Strength Dynamometer; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism*
chemical_list: D015415:Biomarkers