title: Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata.
abstract: Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.
authors.affiliation: Department of Biosystems and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Nguyen Tuan
authors.initials: NT
authors.lastname: Hiep
authors.affiliation: Department of Biosystems and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Kwon
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: Korea Forest Research Institute, Seoul 130-712, Republic of Korea.
authors.forename: Hak-Ju
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: mars@snu.ac.kr.
authors.forename: Woongchon
authors.initials: W
authors.lastname: Mar
authors.affiliation: Department of Biosystems and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: dongholee@korea.ac.kr.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
mesh_terms: D016923:Cell Death / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016627:Oxidopamine / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D007529:Isoflavones; D018696:Neuroprotective Agents; D016627:Oxidopamine
keywords: 6-OHDA; Cudrania tricuspidata; Human neuroblastoma SH-SY5Y; Isoflavones; Moraceae; Neuroprotection; Parkinson’s disease