title: Use of High-Flow Continuous Renal Replacement Therapy with Citrate Anticoagulation to Control Intracranial Pressure by Maintaining Hypernatremia in a Patient with Acute Brain Injury and Renal Failure.
abstract: Traumatic brain injury and intracranial hypertension often require treatment to optimize patient outcome. There are a variety of complex medical conditions that can preclude standard approaches to the treatment of intracranial hypertension. We describe a case where a novel approach using continuous dialysis with trisodium citrate was used to optimize the outcome of a young male with acute renal failure and acute respiratory distress syndrome in the setting of acute traumatic brain injury.
authors.affiliation: Department of Neurosurgery, University of Wisconsin, Madison, WI USA medow@neurosurgery.wisc.edu.
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Medow
authors.affiliation: Department of Medicine, Section of Nephrology, University of Wisconsin, Madison, WI USA.
authors.forename: Shalin R
authors.initials: SR
authors.lastname: Sanghvi
authors.affiliation: Department of Medicine, Section of Nephrology, University of Wisconsin, Madison, WI USA.
authors.forename: R Michael
authors.initials: RM
authors.lastname: Hofmann
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy*; D000293:Adolescent; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D001930:Brain Injuries / Q000150:complications / Q000628:therapy*; D002951:Citrates / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced*; D007427:Intracranial Pressure; D008297:Male; D017582:Renal Replacement Therapy / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000628:therapy
chemical_list: D000925:Anticoagulants; D002951:Citrates; C514290:trisodium citrate
keywords: CRRT; CVVH; Dialysis; Intracranial pressure; Renal failure