title: Steroidal saponins obtained by biotransformation of total furostanol glycosides from Dioscorea zingiberensis with Absidia coerulea.
abstract: Five new steroidal saponins (1-5) were isolated from the fermentation broth of total furostanol glycosides from tubers of Dioscorea zingiberensis C.H. Wright incubated with a fungal, Absidia coerulea AS 3.3389, along with known saponins, zingiberensis new saponin (6), deltonin (7), prosapogenin A of dioscin (8), and protobioside (9), and their structures were established by NMR spectroscopy and mass spectrometry as well as by comparison with previously reported spectral data in the literatures. The induced effects in vitro on rat platelet aggregation of all compounds were evaluated.
authors.affiliation: Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China; Center for Culture Collection of Pharmaceutical Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China; College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Xiong
authors.affiliation: College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Center for Culture Collection of Pharmaceutical Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yu
authors.affiliation: Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China. Electronic address: mabaiping@sina.com.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
mesh_terms: D020095:Absidia / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D027742:Dioscorea / Q000737:chemistry*; D005285:Fermentation; D006027:Glycosides / Q000378:metabolism*; D008297:Male; D018514:Plant Structures / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013213:Starch / Q000378:metabolism; D013256:Steroids / Q000737:chemistry*; D013261:Sterols / Q000378:metabolism*
chemical_list: D006027:Glycosides; D012503:Saponins; D013256:Steroids; D013261:Sterols; C574436:furostanol glycoside; D013213:Starch
keywords: Absidia coerulea; Biotransformation; Dioscorea zingiberensis; Dioscoreaceae; Induced-platelet aggregation activity; Steroidal saponins