title: Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series.
abstract: METHODS
  We report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers.
  
  
  METHODS
  There were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm(2) of the wound surface with half of the amount being injected 1-2 mm deep into the wound and the wound surface was covered with the remaining half.
  
  
  RESULTS
  Complete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements.
  
  
  CONCLUSIONS
  Platelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.
authors.affiliation: Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey drlabarna@gmail.com.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Aksoy
authors.affiliation: Department of Cardiovascular Surgery, Gulhane Medical Military Academy, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Doganci
authors.affiliation: Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Yalcinkaya
authors.affiliation: Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey.
authors.forename: Adem I
authors.initials: AI
authors.lastname: Diken
authors.affiliation: Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey.
authors.forename: Kerim
authors.initials: K
authors.lastname: Cagli
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey; D014647:Varicose Ulcer / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D014689:Venous Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing; D055815:Young Adult
keywords: Platelet-rich plasma; chronic venous insufficiency; wound