title: [Non-palpable breast cancer malignant on needle core biopsy and no malignancy in surgical excision: how to manage?].
abstract: OBJECTIVE
  Despite the standard management of non-palpable breast cancer (needle core biopsy diagnostic, accurate preoperative localization), there are differences in some cases between the malignant histo-pathological finding in diagnostic biopsy results and negative histo-pathological finding after surgical excision. The aim of this study is to evaluate this incidence and classifying them under three category: failure of surgical excision after preoperative identification; removal of the tumor was already completed by percutaneous biopsy; percutaneous biopsy true false positive.
  
  
  METHODS
  We conducted a study based on prospective database, all patients included in this study had partial mastectomy for ductal carcinoma in-situ or invasive cancer which was diagnosed by needle core biopsy and normal/benign after surgery.
  
  
  RESULTS
  Regarding the partial mastectomy, 1863 was performed in the last three years in our center. Thirty-seven patients (2%) correspond our study criteria. After discussion of cases in our multidisciplinary reunion, 6 patients (16%) were considered as failure of surgical excision, 26 patients (70%) as true removal of the whole lesion in the core, and 5 patients (13%) as true false-positive cores.
  
  
  CONCLUSIONS
  This is the first study witch investigate all factors that influence the results of negative final histo-pathological finding of surgical excision of the tumor after malignant diagnostic needle core biopsy. This rare situation need a multidisciplinary meeting to analyse all the steps of management and to determine causes of those false results and try to find adequate management to solve this problem.
authors.affiliation: Département de sénologie, centre Oscar-Lambret, 3, rue F.-Combemale, 59020 Lille cedex, France. Electronic address: cheurfa_nahla@yahoo.fr.
authors.forename: N
authors.initials: N
authors.lastname: Cheurfa
authors.affiliation: Département de sénologie, centre Oscar-Lambret, 3, rue F.-Combemale, 59020 Lille cedex, France. Electronic address: s-giard@o-lambret.fr.
authors.forename: S
authors.initials: S
authors.lastname: Giard
mesh_terms: D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D016208:Databases, Factual; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D017211:Treatment Failure
keywords: Biopsie positive; Cancer du sein infra-clinique; False–positive cores; Needle core biopsy; Non-palpable breast cancer; Pièce opératoire blanche