title: Genomic characterization of two novel HIV-1 second-generation recombinant forms among men who have sex with men in Beijing, China.
abstract: We report two different unique HIV-1 recombinant viruses from two HIV-positive men who have sex with men (MSM) in Beijing, China. Phylogenetic analysis of near full-length genomes (NFLG) showed that the unique recombinant forms (URFs) were comprised of gene regions from two circulating recombinant forms, CRF01_AE and CRF07_BC, both common in China. The parental CRF01_AE region of the recombinants clustered together with a previously described cluster 4 lineage of CRF01_AE. The CRF07_BC regions of both the recombinants clustered within the CRF07_BC radiation, but were distinct from other CRF07_BC reference sequences. The two recombinant forms had two breakpoints in common. The emergence of the two URFs indicates the ongoing generation of recombinant viruses involving CRF01_AE and CRF07_BC, and may provide insight into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.
authors.affiliation: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Marcia L
authors.initials: ML
authors.lastname: Kalish
authors.forename: Hongyan
authors.initials: H
authors.lastname: Lu
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.forename: Han-Zhu
authors.initials: HZ
authors.lastname: Qian
authors.forename: Simon D W
authors.initials: SD
authors.lastname: Frost
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.forename: Sten H
authors.initials: SH
authors.lastname: Vermund
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
mesh_terms: D000328:Adult; D002681:China; D016000:Cluster Analysis; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology