title: Fabrication of dual-pore scaffolds using SLUP (salt leaching using powder) and WNM (wire-network molding) techniques.
abstract: In this study, a novel technique was proposed to fabricate dual-pore scaffolds combining both SLUP (salt leaching using powder) and WNM (wire-network molding) techniques. This technique has several advantages: solvent-free, no limit on the use of thermoplastic polymers as a raw material, and easiness of fabricating scaffolds with dual-scale pores that are interconnected randomized small pores. To fabricate dual-pore scaffolds, PCL and NaCl powders were mixed at a certain ratio. Subsequently, needles were inserted into a designed mold, and the mixture was filled into the mold thereafter. Subsequently, after the mold was pressurized, the mold was heated to melt the PCL powders. The PCL/NaCl structure and needles were separated from the mold. The structure was sonicated to leach-out the NaCl particles and was dried. Consequently, the remaining PCL structure became the dual-pore scaffold. To compare the characteristics of dual-pore scaffolds, control scaffolds, which are 3D plotter and SLUP scaffolds were fabricated.
authors.affiliation: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Cho
authors.affiliation: Department of Orthopedic Sugery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Myoung Wha
authors.initials: MW
authors.lastname: Hong
authors.affiliation: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: So-Youn
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Nature-Inspired Nano Convergence System, Nano Convergence and Manufacturing Systems Research Division, Korea Institute of Machinery and Materials (KIMM), 156, Gajeongbuk-Ro, Yuseong-Gu, Daejeon 305-343, Republic of Korea.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Orthopedic Sugery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea. Electronic address: kimtwins72@catholic.ac.kr.
authors.forename: Young Yul
authors.initials: YY
authors.lastname: Kim
authors.affiliation: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea. Electronic address: youngsamcho@wku.ac.kr.
authors.forename: Young-Sam
authors.initials: YS
authors.lastname: Cho
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D012965:Sodium Chloride / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D012965:Sodium Chloride
keywords: Dual-pore scaffold; PCL (polycaprolactone); SLUP (salt leaching using powder); Tissue engineering; WNM (wire-network molding)