title: Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.
abstract: In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: chin.chiang@vanderbilt.edu.
authors.forename: Chin
authors.initials: C
authors.lastname: Chiang
authors.affiliation: Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Neurological Surgery, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: rebecca.ihrie@vanderbilt.edu.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Ihrie
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology*; D055495:Neurogenesis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051560:Proto-Oncogene Proteins c-bcl-6; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: C084103:BCL6 protein, human; C411984:BCOR protein, human; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D012097:Repressor Proteins; D056564:Sirtuin 1