title: Reprogramming during epithelial to mesenchymal transition under the control of TGFβ.
abstract: Epithelial-mesenchymal transition (EMT) refers to plastic changes in epithelial tissue architecture. Breast cancer stromal cells provide secreted molecules, such as transforming growth factor β (TGFβ), that promote EMT on tumor cells to facilitate breast cancer cell invasion, stemness and metastasis. TGFβ signaling is considered to be abnormal in the context of cancer development; however, TGFβ acting on breast cancer EMT resembles physiological signaling during embryonic development, when EMT generates or patterns new tissues. Interestingly, while EMT promotes metastatic fate, successful metastatic colonization seems to require the inverse process of mesenchymal-epithelial transition (MET). EMT and MET are interconnected in a time-dependent and tissue context-dependent manner and are coordinated by TGFβ, other extracellular proteins, intracellular signaling cascades, non-coding RNAs and chromatin-based molecular alterations. Research on breast cancer EMT/MET aims at delivering biomolecules that can be used diagnostically in cancer pathology and possibly provide ideas for how to improve breast cancer therapy.
authors.affiliation: a Ludwig Institute for Cancer Research; Science for Life Laboratory; Uppsala University ; Uppsala , Sweden ;
authors.forename: E-Jean
authors.initials: EJ
authors.lastname: Tan
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Olsson
authors.forename: Aristidis
authors.initials: A
authors.lastname: Moustakas
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D065150:Cellular Reprogramming; D044127:Epigenesis, Genetic; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D051379:Mice; D014411:Neoplastic Stem Cells / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D022661:RNA, Untranslated; D016212:Transforming Growth Factor beta
keywords: BMP, bone morphogenetic protein; CSC, cancer stem cell; DNMT, DNA methyltransferase; EMT, epithelial-mesenchymal transition; FGF, fibroblast growth factor; HDAC, histone deacetylase; MAPK, mitogen activated protein kinase; MET, mesenchymal-epithelial transition; PDGF, platelet derived growth factor; PRC, polycomb repressive complex; TF, transcription factor; TGFβ; bHLH, basic helix-loop-helix; epithelial-mesenchymal transition; lncRNA, long non-coding RNA; mTORC, mammalian target of rapamycin complex; miRNA, micro-RNA; signal transduction; transforming growth factor β; transforming growth factor β.; tumor invasiveness