title: Kinetic model of continuous ethanol fermentation in closed-circulating process with pervaporation membrane bioreactor by Saccharomyces cerevisiae.
abstract: Unstructured kinetic models were proposed to describe the principal kinetics involved in ethanol fermentation in a continuous and closed-circulating fermentation (CCCF) process with a pervaporation membrane bioreactor. After ethanol was removed in situ from the broth by the membrane pervaporation, the secondary metabolites accumulated in the broth became the inhibitors to cell growth. The cell death rate related to the deterioration of the culture environment was described as a function of the cell concentration and fermentation time. In CCCF process, 609.8 g L(-1) and 750.1 g L(-1) of ethanol production were obtained in the first run and second run, respectively. The modified Gompertz model, correlating the ethanol production with the fermentation period, could be used to describe the ethanol production during CCCF process. The fitting results by the models showed good agreement with the experimental data. These models could be employed for the CCCF process technology development for ethanol fermentation.
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Senqing
authors.initials: S
authors.lastname: Fan
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Chen
authors.affiliation: Biogas Institute of Ministry of Agriculture, Chengdu 610041, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Tang
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China. Electronic address: mgch@scu.edu.cn.
authors.forename: Zeyi
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Deng
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Peina
authors.initials: P
authors.lastname: Yao
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Zhaopeng
authors.initials: Z
authors.lastname: Sun
authors.affiliation: School of Chemical Engineering, Sichuan University, 610065 Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest Petroleum University, 610500 Chengdu, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Chen
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D049109:Cell Proliferation; D002470:Cell Survival; D003198:Computer Simulation; D000431:Ethanol / Q000378:metabolism*; D005285:Fermentation; D007700:Kinetics; D008567:Membranes, Artificial; D050296:Microbial Viability; D008962:Models, Theoretical; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors; D014835:Volatilization
chemical_list: D008567:Membranes, Artificial; D000431:Ethanol
keywords: CCCF process; Ethanol fermentation; Kinetic models; Pervaporation membrane bioreactor; Secondary metabolite inhibition