title: Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.
abstract: In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Angad P
authors.initials: AP
authors.lastname: Mehta
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Sameh H
authors.initials: SH
authors.lastname: Abdelwahed
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Nilkamal
authors.initials: N
authors.lastname: Mahanta
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Dmytro
authors.initials: D
authors.lastname: Fedoseyenko
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Philmus
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Cooper
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and.
authors.forename: Isita
authors.initials: I
authors.lastname: Jhulki
authors.affiliation: the Department of Chemistry, Cornell University, Ithaca, New York 14850.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Ealick
authors.affiliation: From the Department of Chemistry, Texas A&M University, College Station, Texas 77843 and begley@chem.tamu.edu.
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
mesh_terms: D000818:Animals; D003067:Coenzymes / Q000737:chemistry / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry*; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism; D008745:Methylation; D000090006:Molybdenum Cofactors; D011496:Protein Methyltransferases / Q000378:metabolism*; D011621:Pteridines / Q000737:chemistry / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000737:chemistry / Q000378:metabolism*; D013831:Thiamine / Q000737:chemistry / Q000378:metabolism; D024482:Vitamin K 2 / Q000737:chemistry / Q000378:metabolism
chemical_list: D003067:Coenzymes; D005609:Free Radicals; D006418:Heme; D008667:Metalloproteins; D000090006:Molybdenum Cofactors; D011496:Protein Methyltransferases; D011621:Pteridines; D012436:S-Adenosylmethionine; D013831:Thiamine; D024482:Vitamin K 2; C022261:molybdopterin
keywords: Biosynthesis; Deazaflavin; Enzyme Mechanism; Heme; Menaquinone; Molybdopterin; Rearrangement; S-Adenosylmethionine (SAM); Thiamin; radical