title: Eradication of Pseudomonas aeruginosa in adults with cystic fibrosis.
abstract: BACKGROUND
  Eradication of new infection of Pseudomonas aeruginosa is an important intervention in managing cystic fibrosis (CF). Previous trials, studying predominantly under 18-year-olds, indicate that antibiotic eradication therapy (AET) has success rates of 62.8-93.0%. In this retrospective cohort study, we report the outcomes of AET in an adult population.
  
  
  METHODS
  Adults with a confirmed diagnosis of CF and a first isolation of P aeruginosa were studied between 1999 and 2012. Choice of therapy, time to eradication and reinfection, and lung function (forced expiratory volume in 1 s (FEV1)) were determined.
  
  
  RESULTS
  20 patients (median age 27 years) isolated P aeruginosa during the study period. 10 patients were treated with oral ciprofloxacin (median duration 6 weeks) and nebulised colomycin (median duration 3 months). 7 patients were treated with intravenous antipseudomonal antibiotics (median duration 14 days). 2 patients received other combinations of oral and inhaled antipseudomonal therapy and one patient received no therapy. AET was successful in 15 cases who received antipseudomonal therapy (79%). The median time to eradication was 1 month. The median time to reinfection with P aeruginosa was 43 months. There was no significant change in FEV1 after 12 months.
  
  
  CONCLUSIONS
  Aggressive AET of new infection of P aeruginosa in adults is successful in the majority of patients and has similar efficacy to the reported efficacy in paediatric populations.
authors.affiliation: Centre for Infection and Immunity, Queen's University Belfast , Belfast , UK ; Adult CF Centre, BHSCT , Belfast , UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Kenny
authors.affiliation: Centre for Infection and Immunity, Queen's University Belfast , Belfast , UK ; Adult CF Centre, BHSCT , Belfast , UK.
authors.forename: T D
authors.initials: TD
authors.lastname: Shaw
authors.affiliation: Adult CF Centre, BHSCT , Belfast , UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Downey
authors.affiliation: Department of Bacteriology , Belfast City Hospital , Belfast , UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Moore
authors.affiliation: Adult CF Centre, BHSCT , Belfast , UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Rendall
authors.affiliation: Centre for Infection and Immunity, Queen's University Belfast , Belfast , UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Elborn
keywords: Bacterial Infection; Cystic Fibrosis; Respiratory Infection