title: Genetic polymorphism study on 12 X STR loci of investigator Argus X STR kit in Bhil tribal population of Madhya Pradesh, India.
abstract: The analysis of 12 X STR loci (DXS10103, DXS8378, DXS7132, DXS10134, DXS10074, DXS10101, DXS10135, DXS7423, DXS10146, DXS10079, HPRTB and DXS10148) belonging to four linkage group was done in 183 (100 males and 83 females) unrelated members of Bhil population. Heterozygosity among the studied 12 X STR loci showed a distribution of from 59.7% to 92.8%. No significant difference was recorded in the allele frequencies of males and females. The loci DXS10135 and DXS10101 were found to be most polymorphic. Haplotype diversity was found to be higher than 0.990 for all the four linkage groups. A total of 86, 69, 71 and 71 haplotypes were observed for linkage group I, II, III and IV, respectively. The results showed departure from Hardy-Weinberg equilibrium with respect to three loci DXS10079, DXS10135 and DXS10101. This is first report on these 12 X STR markers from India. All the loci in the Argus X 12 kit were fairly informative in the Bhil population and the population showed significant genetic variation with all the compared populations from other parts of the world.
authors.affiliation: DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of Madhya Pradesh, Sagar 470001 (MP), India. Electronic address: pankaj.shrivastava@rediffmail.com.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Shrivastava
authors.affiliation: DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of Madhya Pradesh, Sagar 470001 (MP), India.
authors.forename: Toshi
authors.initials: T
authors.lastname: Jain
authors.affiliation: DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of Madhya Pradesh, Sagar 470001 (MP), India.
authors.forename: Umang
authors.initials: U
authors.lastname: Gupta
authors.affiliation: DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of Madhya Pradesh, Sagar 470001 (MP), India.
authors.forename: Veena Ben
authors.initials: VB
authors.lastname: Trivedi
mesh_terms: D041321:Chromosomes, Human, X / Q000235:genetics*; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007194:India; D008297:Male; D018895:Microsatellite Repeats; D060885:Multiplex Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*
keywords: Argus X 12; Bhil; DNA typing; Forensic science; Population study; X STR