title: The neurophysiology of language: Insights from non-invasive brain stimulation in the healthy human brain.
abstract: With the advent of non-invasive brain stimulation (NIBS), a new decade in the study of language has started. NIBS allows for testing the functional relevance of language-related brain activation and enables the researcher to investigate how neural activation changes in response to focal perturbations. This review focuses on the application of NIBS in the healthy brain. First, some basic mechanisms will be introduced and the prerequisites for carrying out NIBS studies of language are addressed. The next section outlines how NIBS can be used to characterize the contribution of the stimulated area to a task. In this context, novel approaches such as multifocal transcranial magnetic stimulation and the condition-and-perturb approach are discussed. The third part addresses the combination of NIBS and neuroimaging in the study of plasticity. These approaches are particularly suited to investigate short-term reorganization in the healthy brain and may inform models of language recovery in post-stroke aphasia.
authors.affiliation: Department of Psychology, Christian-Albrechts-University Kiel, Germany. Electronic address: hartwigsen@psychologie.uni-kiel.de.
authors.forename: Gesa
authors.initials: G
authors.lastname: Hartwigsen
mesh_terms: D001037:Aphasia / Q000503:physiopathology / Q000534:rehabilitation; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D064368:Healthy Volunteers; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity / Q000502:physiology; D050781:Transcranial Magnetic Stimulation
keywords: Broca; Network; Plasticity; Recovery; Reorganization; Speech; Transcranial direct current stimulation; Transcranial magnetic stimulation; Virtual lesion; Wernicke