title: Synthesis, crystal and solution structures and antimicrobial screening of palladium(II) complexes with 2-(phenylselanylmethyl)oxolane and 2-(phenylselanylmethyl)oxane as ligands.
abstract: Two novel Pd(II) complexes with 2-(phenylselanylmethyl)oxolane and 2-(phenylselanylmethyl)oxane as ligands were synthesized. The crystal and molecular structure of the complexes has been determined by single crystal X-ray diffraction. It turned out for both complexes that the two ligands are coordinated to Pd via Se atoms in a trans-fashion and the other two trans-positions are occupied by Cl ions. Detailed 1D- and 2D-NMR analyses revealed the existence of equilibrating trans-diastereomeric species differing in the configuration at four chiral centers (selenium and carbon) in the solution of the complexes. A computational study was also undertaken to assess the relative stabilities of the mentioned stereoisomeric species. The antimicrobial properties of the complexes were investigated against a series of human pathogenic bacterial and fungal strains. The complexes were shown to possess promising broad spectrum moderate antimicrobial activity that is more pronounced against fungal organisms. The noted activity could be completely attributed to the Pd(II) center, whereas the ligands probably mediate the transportation of a Pd(II) species across cell membranes.
authors.affiliation: Faculty of Science, Department of Chemistry, University of Kragujevac, Radoja Domanovića 12, Kragujevac 34 000, Serbia. Electronic address: zoricab@kg.ac.rs.
authors.forename: Zorica M
authors.initials: ZM
authors.lastname: Bugarčić
authors.affiliation: Faculty of Science, Department of Chemistry, University of Kragujevac, Radoja Domanovića 12, Kragujevac 34 000, Serbia.
authors.forename: Vera M
authors.initials: VM
authors.lastname: Divac
authors.affiliation: Faculty of Science, Department of Chemistry, University of Kragujevac, Radoja Domanovića 12, Kragujevac 34 000, Serbia.
authors.forename: Marina D
authors.initials: MD
authors.lastname: Kostić
authors.affiliation: Faculty of Science, Department of Chemistry, University of Kragujevac, Radoja Domanovića 12, Kragujevac 34 000, Serbia.
authors.forename: Nenad Ž
authors.initials: NŽ
authors.lastname: Janković
authors.affiliation: Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstrasse 1, Erlangen 91058, Germany.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Heinemann
authors.affiliation: Faculty of Science and Mathematics, Department of Chemistry, University of Niš, Višegradska 33, Niš 18000, Serbia.
authors.forename: Niko S
authors.initials: NS
authors.lastname: Radulović
authors.affiliation: Faculty of Science and Mathematics, Department of Biology and Ecology, University of Niš, Višegradska 33, Niš 18000, Serbia.
authors.forename: Zorica Z
authors.initials: ZZ
authors.lastname: Stojanović-Radić
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000254:growth & development*; D018360:Crystallography, X-Ray; D006801:Humans; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D010165:Palladium
keywords: Antimicrobial activity; Ligands; Organoselenium chemistry; Palladium