title: Dried blood spot analysis to assess medication adherence and to inform personalization of treatment.
abstract: Little research using dried blood spot samples to assess adherence to medication has been reported. The World Health Organisation estimates that only half of the patients in the developed world take their medication as prescribed. Additional costs to the healthcare provider include wasted medicines, avoidable additional hospital visits and non-optimum patient care. There is little evidence of information concerning medication adherence being made available to inform clinical decision making. In this article we explore the potential of the dried blood spot sample collection methodology as a means of identifying medication adherence to facilitate medicines optimization for a range of disparate diseases. Furthermore, the opportunity to personalize healthcare for different patients by assessing the clinically necessary therapeutic level of the relevant drugs is highlighted.
authors.affiliation: Leicester School of Pharmacy, Faculty of Health & Life Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Tanna
authors.forename: Graham
authors.initials: G
authors.lastname: Lawson
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D059788:Dried Blood Spot Testing; D006801:Humans; D055118:Medication Adherence; D010361:Patients / Q000523:psychology; D004364:Pharmaceutical Preparations / Q000097:blood* / Q000191:economics / Q000652:urine; D057285:Precision Medicine / Q000191:economics; D053719:Tandem Mass Spectrometry
chemical_list: D015415:Biomarkers; D004364:Pharmaceutical Preparations