title: Synthesis of novel p-tert-butylcalix[4]arene Schiff bases and their complexes with C60, potential HIV-Protease inhibitors.
abstract: Some p-tert-butylcalix[4]arene Schiff base crown ethers were synthesized, characterized using (1)H, (13)C-NMR, DEPT 135 and Mass spectrometry. Their complexes with C60 were isolated and characterized. The inhibition effect of these complexes on HIVP was studied and found that complexes of 9 and 10 have comparable Ki values to Pepstatine which is known as HIVP inhibitor and used as a control. The synthesis of the ligands, complexes and the inhibition behavior are discussed in this article.
authors.affiliation: Department of Biological Sciences, Yarmouk University, Jordan.
authors.forename: Khalid Abu
authors.initials: KA
authors.lastname: Khadra
authors.affiliation: Chemistry Department, Yarmouk University, Jordan. Electronic address: z79sam@hotmail.com.
authors.forename: Shehadeh
authors.initials: S
authors.lastname: Mizyed
authors.affiliation: Chemistry Department, Yarmouk University, Jordan.
authors.forename: Deeb
authors.initials: D
authors.lastname: Marji
authors.affiliation: Chemistry Department, University of Jordan, Jordan.
authors.forename: Salim F
authors.initials: SF
authors.lastname: Haddad
authors.affiliation: Chemistry Department, Mu'tah University, Jordan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashram
authors.affiliation: Chemistry Department, Yarmouk University, Jordan.
authors.forename: Ayat
authors.initials: A
authors.lastname: Foudeh
keywords: C(60); Calix[4]aren Schiff bases; Complexes; HIV-Protease inhibitors