title: Human health risk assessment of soil dioxin/furans contamination and dioxin-like activity determined by ethoxyresorufin-O-deethylase bioassay.
abstract: The major objective of this study was to evaluate the human health risks of agricultural land use conversion to other purposes in Hong Kong, based on the levels of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/Fs) and determined dioxin-like activity in soil using ethoxyresorufin-O-deethylase (EROD) bioassay. Hazard quotient showed soils of open burning site (OBS) and electronic waste open burning site (EW (OBS)) exert a relatively higher non-cancer risk on adults (50.9 and 8.00) and children (407 and 64.0) via the pathway of accidental ingestion of soil particles than other types of land use. In addition, the levels of 17 PCDD/Fs congeners in OBS and EW (OBS) soils indicated high and moderate (1654 and 260 in one million people) cancer risks through the above pathway. Furthermore, the biologically derived TCDD concentrations (TEQbio) were also significantly correlated to the chemically derived toxic equivalent concentrations of dioxin-like chemicals (TEQcal (sum of chemically derived 2,3,7,8-TeCDD toxic equivalent concentrations (TEQPCDD/F) and chemically derived dioxin-like PAHs toxic equivalent concentrations (TEQPAH)) (r = 0.770, p <0.05). PCDD/Fs (95.4 to 99.9%) were the major stressor to the TEQcal in the soil samples, indicating higher concentrations of PCDD/Fs derived from chemical analyses may reflect a higher potency of inducing EROD activity.
authors.affiliation: Consortium on Health, Environment, Education and Research (CHEER), and Department of Science and Environmental Studies, The Hong Kong Institute of Education, Tai Po, Hong Kong, China.
authors.forename: Yu Bon
authors.initials: YB
authors.lastname: Man
authors.forename: Ka Lai
authors.initials: KL
authors.lastname: Chow
authors.forename: Hong Sheng
authors.initials: HS
authors.lastname: Wang
authors.forename: Xiao Lin
authors.initials: XL
authors.lastname: Sun
authors.forename: Sheng Chun
authors.initials: SC
authors.lastname: Wu
authors.forename: Zong Wei
authors.initials: ZW
authors.lastname: Cai
authors.forename: Yuan
authors.initials: Y
authors.lastname: Kang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jin Shu
authors.initials: JS
authors.lastname: Zheng
authors.forename: John P
authors.initials: JP
authors.lastname: Giesy
authors.forename: Ming Hung
authors.initials: MH
authors.lastname: Wong
mesh_terms: D000328:Adult; D001681:Biological Assay; D002648:Child; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004147:Dioxins / Q000737:chemistry / Q000633:toxicity*; D059029:Electronic Waste; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004787:Environmental Pollution / Q000032:analysis*; D005663:Furans / Q000737:chemistry / Q000633:toxicity*; D006723:Hong Kong; D006801:Humans; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis; D012037:Refuse Disposal; D018570:Risk Assessment; D012987:Soil; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity*
chemical_list: D004147:Dioxins; D005663:Furans; D000072317:Polychlorinated Dibenzodioxins; D012987:Soil; D012989:Soil Pollutants; D019363:Cytochrome P-450 CYP1A1