title: Endoscopic papillary large balloon dilation for removal of bile duct stones.
abstract: OBJECTIVE
  To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation (EPLBD) for bile duct stones in a multicenter prospective study.
  
  
  METHODS
  Lithotomy by EPLBD was conducted in 124 patients with bile duct stones ≥ 13 mm in size or with three or more bile duct stones ≥ 10 mm. After endoscopic sphincterotomy, the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct diameter.
  
  
  RESULTS
  The success rate of first-time lithotomy was 86.3% (107/124) and the final lithotomy success rate was 100% (124/124). Lithotripsy was needed in 10 of the 124 (13.6%) patients. Adverse events due to the treatment procedure occurred in 6 (4.8%) patients, all of which were mild. Performing large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for lithotripsy.
  
  
  CONCLUSIONS
  It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful.
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sakai
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Tsuyuguchi
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawaguchi
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Nobuto
authors.initials: N
authors.lastname: Hirata
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: So
authors.initials: S
authors.lastname: Nakaji
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kitamura
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Mikami
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fujimoto
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ijima
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Eishin
authors.initials: E
authors.lastname: Kurihara
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Oana
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nishino
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Tamura
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Sakamoto
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Nishikawa
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Harutoshi
authors.initials: H
authors.lastname: Sugiyama
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mine
authors.affiliation: Yuji Sakai, Toshio Tsuyuguchi, Ryo Tamura, Dai Sakamoto, Masato Nakamura, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects / Q000379:methods*; D002769:Cholelithiasis / Q000175:diagnosis* / Q000628:therapy*; D004106:Dilatation; D005260:Female; D006801:Humans; D007564:Japan; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016717:Sphincterotomy, Endoscopic; D016896:Treatment Outcome
keywords: Endoscopic papillary large balloon dilation; Endoscopic retrograde cholangiopancreatography; Endoscopic sphincterotomy; Large bile duct stones; Multiple bile duct stones