title: (Lipo)polysaccharide interactions of antimicrobial peptides.
abstract: Due to rapidly increasing resistance development against conventional antibiotics, as well as problems associated with diseases either triggered or deteriorated by infection, antimicrobial and anti-inflammatory peptides have attracted considerable interest during the last few years. While there is an emerging understanding of the direct antimicrobial function of such peptides through bacterial membrane destabilization, the mechanisms of their anti-inflammatory function are less clear. We here summarize some recent results obtained from our own research on anti-inflammatory peptides, with focus on peptide-(lipo)polysaccharide interactions.
authors.affiliation: Section of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden; Dermatology, LKCMedicine, Nanyang Technological University, Singapore 308232, Singapore.
authors.forename: Artur
authors.initials: A
authors.lastname: Schmidtchen
authors.affiliation: Department of Pharmacy, Uppsala University, P.O. Box 580, SE-751 23 Uppsala, Sweden. Electronic address: martin.malmsten@farmaci.uu.se.
authors.forename: Martin
authors.initials: M
authors.lastname: Malmsten
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology*; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000276:immunology
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D016328:NF-kappa B
keywords: Anti-inflammatory; Antimicrobial; Lipid A; Lipopolysaccharide; Peptide