title: Association between hepatitis C virus and opioid use while in buprenorphine treatment: preliminary findings.
abstract: BACKGROUND
  The prevalence of hepatitis-C-virus (HCV) infections is high among opioid-dependent individuals. Prior research on the simultaneous treatment of both conditions has primarily assessed success as it pertains to HCV. However, it has been noted that favorable substance use therapy outcomes may improve the likelihood of HCV-treatment initiation and success. Therefore, current guidelines for the treatment of HCV among illicit drug users suggest that treatment for addiction be given the highest priority.
  
  
  OBJECTIVE
  To determine whether opioid-dependent participants in a clinical trial of buprenorphine-treatment tapering regimens, who tested positive for the HCV antibody, experienced significantly different levels of opioid abstinence than those not infected.
  
  
  METHODS
  Data came from the National Drug Abuse Treatment Clinical Trial Network study 0003. 516 eligible opioid-dependent participants were randomized to either a 7-day or 28-day buprenorphine tapering schedule following a 4-week buprenorphine stabilization period. Generalized estimating equations were used to test the research question.
  
  
  RESULTS
  Participants with the HCV antibody were significantly less likely to submit opioid-negative urine analyses during and/or immediately following active treatment [OR = 0.69; CI = 0.51-0.93], indicating a higher rate of opioid use among this group.
  
  
  CONCLUSIONS
  Individualized opioid-dependence treatment strategies may be required for opioid-dependent individuals who test positive for the HCV antibody in order to ensure resources for both opioid-dependence and HCV therapies are used efficiently.
authors.affiliation: Department of Health Policy and Administration, Washington State University , Spokane, Washington , USA .
authors.forename: Sean M
authors.initials: SM
authors.lastname: Murphy
authors.forename: Dana
authors.initials: D
authors.lastname: Dweik
authors.forename: Sterling
authors.initials: S
authors.lastname: McPherson
authors.forename: John M
authors.initials: JM
authors.lastname: Roll
mesh_terms: D000293:Adolescent; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D009293:Opioid-Related Disorders / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D006508:Hepatitis Antibodies; D009292:Narcotic Antagonists; D002047:Buprenorphine
keywords: Buprenorphine; Opioid dependence; hepatitis C