title: Association between the prothrombin G20210A mutation and sudden sensorineural hearing loss in European population: a meta-analysis.
abstract: OBJECTIVE
  Epidemiological studies have reported inconsistent findings on the association between the prothrombin G20210A mutation and sudden sensorineural hearing loss (SSNHL) in European population. The aim of this meta-analysis was to clarify the association of this polymorphism with SSNHL in European population.
  
  
  METHODS
  PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to August 1, 2014. We used STATA12.0 to calculate summary odds ratios (ORs) with 95% confidence intervals (CIs).
  
  
  RESULTS
  Eight studies including 1972 patients were identified. Pooled data showed no significant association between the prothrombin G20210A mutation and risk of SSNHL in European population : A vs. G (OR =1.645, 95% CI:0.78-3.49,POR =0.194); AG vs.GG (OR =1.660, 95% CI:0.77-3.60,POR=0.199).
  
  
  CONCLUSIONS
  The present meta-analysis suggests that the prothrombin G20210A mutation is not significantly associated with an increased risk of SSNHL in European population.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Shu
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. Electronic address: shihuayin02@126.com.
authors.forename: Shihua
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: An-Zhou
authors.initials: AZ
authors.lastname: Tan
authors.affiliation: Department of Obstetrics and Gynecology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Meirong
authors.initials: M
authors.lastname: He
mesh_terms: D000483:Alleles; D005060:Europe; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D009154:Mutation; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D011516:Prothrombin
keywords: Meta-analysis; Mutation; Prothrombin; Sudden sensorineural hearing loss