title: Differential lncRNA expression profiles in brown and white adipose tissues.
abstract: Long non-coding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. It can serve as key co-activators of proteins involved in transcriptional regulation. Studies have found that white and brown adipocytes both originate from the mesoderm. However, it remains unclear whether lncRNAs function during adipogenesis or in energy metabolism in brown adipose tissue (BAT) and white adipose tissue (WAT). In this study, we used lncRNA microarray technology to evaluate differences in the lncRNA expression profiles of WAT and BAT. We observed 735 up-regulated and 877 down-regulated lncRNAs (fold change >4.0). To reveal the potential functions of these lncRNAs, we applied GO and pathway analyses to study the differentially expressed lncRNAs. We found that AK142386 and AK133540 may affect adipogenesis and metabolism. Our data indicate that AK142386 and AK133540 may be involved in BAT and WAT development through their target genes Hoxa3 and Acad10. Together, we have identified numerous lncRNAs and these lncRNAs can potentially serve as a required component for proper adipogenesis.
authors.affiliation: Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital Affiliated with Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Chen
authors.forename: Xianwei
authors.initials: X
authors.lastname: Cui
authors.forename: Chunmei
authors.initials: C
authors.lastname: Shi
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Lingxia
authors.initials: L
authors.lastname: Pang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xirong
authors.initials: X
authors.lastname: Guo
authors.forename: Jiaqin
authors.initials: J
authors.lastname: Wang
authors.forename: Chenbo
authors.initials: C
authors.lastname: Ji
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D063990:Gene Ontology; D008297:Male; D008810:Mice, Inbred C57BL; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome
chemical_list: D062085:RNA, Long Noncoding