title: Alterations in circadian/seasonal rhythms and vegetative functions are related to suicidality in DSM-5 PTSD.
abstract: BACKGROUND
  Alterations in rhythmicity and vegetative functions have been reported as correlates of suicidality, particularly in patients with mood disorders. No investigation has addressed their impact on patients with post-traumatic stress disorder (PTSD). Aim of the present study was to fulfill this gap.
  
  
  METHODS
  Sixty-five out- and inpatients with DSM-5 PTSD were assessed by using the Mood Spectrum-Self Report-Lifetime Version (MOODS-SR), a questionnaire for lifetime mood spectrum symptomatology including alterations in circadian/seasonal rhythms and vegetative functions. Six items of the MOODS-SR were combined and dichotomized to assess suicidal ideation and/or attempts.
  
  
  RESULTS
  Significant and positive associations were found between symptoms of lifetime dysregulations in rhythmicity and vegetative functions and suicidal ideation and/or attempts. All MOODS-SR sub-domains (rhythmicity, sleep, appetite/weight, sexual function, physical symptoms) were associated with an increased likelihood of suicidal ideation, but only changes in appetite/weight were associated with greater odd ratios of suicide attempts (OR = 2.099, 95% CI 1.148-3.841).
  
  
  CONCLUSIONS
  Our results suggest that lifetime dysregulations in rhythmicity and vegetative functions may represent correlates of suicidality in patients with DSM-5 PTSD.
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, 56126, Italy. liliana.dellosso@med.unipi.it.
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, 56126, Italy. gabriele.massimetti@med.unipi.it.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Massimetti
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, 56126, Italy. psicologiaapplicata@gmail.com.
authors.forename: Ciro
authors.initials: C
authors.lastname: Conversano
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, 56126, Italy. carlo.ab@hotmail.it.
authors.forename: Carlo Antonio
authors.initials: CA
authors.lastname: Bertelloni
authors.affiliation: Department of Public Health, University of Cagliari, Cagliari, Italy. mgcarta@tiscali.it.
authors.forename: Mauro Giovanni
authors.initials: MG
authors.lastname: Carta
authors.affiliation: Department of Neuropsychiatry, University of Florence, Florence, Italy. valdo.ricca@unifi.it.
authors.forename: Valdo
authors.initials: V
authors.lastname: Ricca
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, 56126, Italy. ccarmassi@gmail.com.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carmassi
mesh_terms: D000328:Adult; D021081:Chronobiology Disorders / Q000175:diagnosis / Q000523:psychology*; D002940:Circadian Rhythm / Q000502:physiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000523:psychology*; D012621:Seasons; D012890:Sleep / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000523:psychology*; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology; D011795:Surveys and Questionnaires