title: [Effect of different concentrations liposomal emoxipine on coronary flow, contractive and pump function of the isolated rat heart after normotermic ischema and further reperfusion].
abstract: In the experiments on the isolated perfused rat heart we studied the effects of liposomes containing different concentrations (0.25 and 0.1 mg/ml) of emoxipine on coronary flow, contractive and pump function of the isolated heart, which was effected by total normothermical ischemia and reperfusion. The parameters of the contractile activity of hearts, coronary flow and pump function of the hearts were assessed. It was detected that the introduction of the liposomal emoxipine during ischemia provides a protective effect against ischemic and reperfusion myocardial damage and smaller concentration of the emoxipin (0.1 mg/ml) in composition with the liposomes promote the best recovery of contractile activity and the pumping function of the ischemic heart in the period of the reperfusion.
authors.forename: Ia G
authors.initials: IaG
authors.lastname: Toropova
authors.forename: R A
authors.initials: RA
authors.lastname: Mukhamadiiarov
authors.forename: A S
authors.initials: AS
authors.lastname: Golovkin
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009924:Organ Culture Techniques; D010847:Picolines / Q000008:administration & dosage; D051381:Rats
chemical_list: D008081:Liposomes; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine