title: The value of SPECT/CT in localizing pain site and prediction of treatment response in patients with chronic low back pain.
abstract: In many circumstances, causing sites of low back pain (LBP) cannot be determined only by anatomical imaging. Combined functional and morphological imaging such as bone scan with single-photon emission computed tomography/computed tomography (SPECT/CT) may be helpful in identifying active lesions. The purpose of this study was to evaluate the usefulness of bone SPECT/CT in localizing the pain site and the treatment of chronic LBP. One hundred seventy-five patients suffering from chronic LBP who underwent SPECT/CT were included, retrospectively. All of the patients received multiple general treatments according to the symptoms, and some of them underwent additional target-specific treatment based on SPECT/CT. Numerical rating scale (NRS) pain score was used to assess the pain intensity. Of 175 patients, 127 showed good response to the given therapies, while the rest did not. Overall, 79.4% of patients with definite active lesions showed good response. Patients with mild active or no lesions on SPECT/CT had relatively lower response rate of 63.0%. Good response was observed by the treatment with the guidance of active lesions identified on SPECT/CT. SPECT/CT could be useful in identifying active lesions in patients with chronic LBP and guiding the clinicians to use adequate treatment.
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Inki
authors.identifier: 0000-0002-2051-3597
authors.initials: I
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Fellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea. ; Department of Nuclear Medicine, MochtarRiady Comprehensive Cancer Centre - Siloam Hospitals Semanggi, Jakarta, Indonesia.
authors.forename: Hendra
authors.identifier: 0000-0002-8645-5916
authors.initials: H
authors.lastname: Budiawan
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jee Youn
authors.identifier: 0000-0001-5551-7750
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Gi Jeong
authors.identifier: 0000-0002-1360-5186
authors.initials: GJ
authors.lastname: Cheon
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Yong Chul
authors.identifier: 0000-0002-8461-5322
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jin Chul
authors.identifier: 0000-0002-7464-9342
authors.initials: JC
authors.lastname: Paeng
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Keon Wook
authors.identifier: 0000-0003-2622-9017
authors.initials: KW
authors.lastname: Kang
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: June-Key
authors.identifier: 0000-0002-6866-8571
authors.initials: JK
authors.lastname: Chung
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Dong Soo
authors.identifier: 0000-0001-9013-4835
authors.initials: DS
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059350:Chronic Pain / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000175:diagnosis* / Q000628:therapy*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010147:Pain Measurement / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Low Back Pain; Pain Management; Technetium-99m (Tc-99m), Methylene Diphosphonate (MDP); Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed