title: Sassarandainol: a new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense.
abstract: A new neolignan, (R)-( - )-sassarandainol (1), together with 10 known compounds (2-11), was isolated from the stem of Sassafras randaiense. The structures were determined by spectroscopic techniques. Among these isolates, γ-tocopherol (5), subamolide B (7) and β-sitosterone (9) exhibited moderate iNOS inhibitory activity on nitrite production induced (%) value of 30.51, 28.68 and 16.96, respectively.
authors.affiliation: a Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University , Kaohsiung 807 , Taiwan, ROC.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Hou
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Wang
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.forename: Tze-Ying
authors.initials: TY
authors.lastname: Chen
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D002460:Cell Line; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D009573:Nitrites / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry*; D027441:Sassafras / Q000737:chemistry*; D012855:Sitosterols; D024504:gamma-Tocopherol / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D017705:Lignans; D009573:Nitrites; D012855:Sitosterols; C000598482:sassarandainol; C517712:subamolide B; C047282:beta-sitosterone; D024504:gamma-Tocopherol; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D015107:4-Butyrolactone
keywords: (R)-( − )-sassarandainol; Lauraceae; Sassafras randaiense; anti-inflammatory activity; neolignan; stem