title: Boosting NAD to spare hearing.
abstract: Ex vivo experiments have strangely shown that inhibition or stimulation of NAD metabolism can be neuroprotective. In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3.
authors.affiliation: Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: charles-brenner@uiowa.edu.
authors.forename: Charles
authors.initials: C
authors.lastname: Brenner
mesh_terms: D000818:Animals; D005260:Female; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control*; D008297:Male; D009243:NAD / Q000627:therapeutic use*; D009536:Niacinamide / Q000031:analogs & derivatives*; D056566:Sirtuin 3 / Q000378:metabolism*
chemical_list: D009243:NAD; D009536:Niacinamide; D056566:Sirtuin 3