title: Evaluation of body adiposity index as a predictor of aortic stiffness in multi-ethnic Asian population with type 2 diabetes.
abstract: Cardiovascular disease is the leading cause of morbidity and mortality in type 2 diabetes mellitus. We evaluated the predictive ability of the recently developed body adiposity index for aortic stiffness, an intermediate endpoint of cardiovascular disease, in a cross-sectional multi-ethnic Asian type 2 diabetes mellitus cohort (N = 1408). AS was estimated using carotid-femoral pulse wave velocity measured by applanation tonometry. Body adiposity index was computed as hip circumference/(height)(1.5) - 18. Compared to body mass index, waist circumference and visceral fat area, body adiposity index displayed the weakest association with pulse wave velocity (r = 0.077, 0.096, 0.134 and 0.058, respectively; all p < 0.05). Interestingly, the relationship between measurements of obesity and pulse wave velocity was ethnic dependent - body mass index, body adiposity index, waist circumference and visceral fat area consistently predicted pulse wave velocity only in Indians but not others. In multi-variable analysis, body mass index was a significant determinant of pulse wave velocity in all ethnicities. In conclusion, body adiposity index is a weak predictor of aortic stiffness (when compared with body mass index) in Asians with type 2 diabetes mellitus.
authors.affiliation: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
authors.forename: Mei Chung
authors.initials: MC
authors.lastname: Moh
authors.affiliation: Diabetes Centre, Khoo Teck Puat Hospital, Singapore.
authors.forename: Chee Fang
authors.initials: CF
authors.lastname: Sum
authors.affiliation: Department of Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.
authors.forename: Benjamin Chih Chiang
authors.initials: BC
authors.lastname: Lam
authors.affiliation: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Ng
authors.affiliation: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
authors.forename: Chang
authors.initials: C
authors.lastname: Su
authors.affiliation: Diabetes Centre, Khoo Teck Puat Hospital, Singapore.
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Tavintharan
authors.affiliation: Department of Medicine, Khoo Teck Puat Hospital, Singapore.
authors.forename: Lee Ying
authors.initials: LY
authors.lastname: Yeoh
authors.affiliation: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
authors.forename: Melvin Ding Sheng
authors.initials: MD
authors.lastname: Wong
authors.affiliation: National Healthcare Group Polyclinics, Singapore.
authors.forename: Simon Biing Ming
authors.initials: SB
authors.lastname: Lee
authors.affiliation: National Healthcare Group Polyclinics, Singapore.
authors.forename: Wern Ee
authors.initials: WE
authors.lastname: Tang
authors.affiliation: Diabetes Centre, Khoo Teck Puat Hospital, Singapore lim.su.chi@alexandrahealth.com.sg.
authors.forename: Su Chi
authors.initials: SC
authors.lastname: Lim
mesh_terms: D050154:Adiposity / Q000208:ethnology*; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D001837:Body Weights and Measures; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000503:physiopathology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000503:physiopathology; D017097:Electric Impedance; D005260:Female; D006615:Hip / Q000503:physiopathology*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000208:ethnology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D063177:Pulse Wave Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D059289:Vascular Stiffness; D055105:Waist Circumference
keywords: Aortic stiffness; body adiposity index; obesity; type 2 diabetes