title: Intracranial venous hemodynamics and rupture of cerebral aneurysm.
abstract: Many uncertain and inconsistent etiologies of cerebral aneurysmal rupture including a wide spectrum of factors have been reported. Our recent observation discloses the potential new factor of cerebral aneurysm rupture with cerebral venous pressure gradient. We retrospectively reviewed 52 cases treated with coil embolization with or without cerebral aneurysmal rupture. Seventeen males and 30 females were recruited in this study. Quantitative color-coded cerebral angiography was performed during coil therapeutic procedures to measure cerebral venous circulation. Ruptured cases had shorter and symmetrical cerebral venous circulation time (P <0.05). In addition, an asymmetrical venous outflow pattern was critical for aneurysmal rupture. Non-ruptured cases tended to have slower and asymmetrical cerebral venous circulation compared with rupture cases. Symmetrical and shorter cerebral venous circulation in the dysplasia venous outlet may be a potential new factor for cerebral aneurysm rupture.
authors.affiliation: Department of Medical Imaging, Vascular and Genomic Research Center, Changhua Christian Hospital; Taipei, Taiwan - Imaging Research Center, Taipei Medical University; Taipei, Taiwan - ftsai@uci.edu - ftsai@tmu.edu.tw.
authors.forename: Kwo-Whei
authors.initials: KW
authors.lastname: Lee
authors.affiliation: Department of Medical Imaging, Changhua Christian Hospital; Taipei, Taiwan - Imaging Research Center, Taipei Medical University; Taipei, Taiwan.
authors.forename: Fong-Y
authors.initials: FY
authors.lastname: Tsai
authors.affiliation: Department of Medical Imaging, Vascular and Genomic Research Center, Changhua Christian Hospital; Taipei, Taiwan.
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging, Vascular and Genomic Research Center, Changhua Christian Hospital; Taipei, Taiwan.
authors.forename: Chi-Kuang
authors.initials: CK
authors.lastname: Liu
authors.affiliation: Vascular and Genomic Research Center, Changhua Christian Hospital; Taipei, Taiwan.
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Kuo
mesh_terms: D000293:Adolescent; D000368:Aged; D017542:Aneurysm, Ruptured / Q000209:etiology / Q000503:physiopathology*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: DSA i-Flow; cerebral aneurysm; circulation time; venous outflow pattern