title: The first trimester: prediction and prevention of the great obstetrical syndromes.
abstract: A number of groups are currently examining the potential of screening for pre-eclampsia and gestational diabetes at 12 weeks' gestation. This can be performed at the time of combined first-trimester screening for aneuploidy using a similar method of regression analysis to combine multiple demographic and investigative factors. At present, research into the prediction of pre-eclampsia is more robust and is associated with the potential for therapeutic intervention that can reduce the prevalence of early-onset pre-eclampsia and improve maternal and neonatal outcomes.
authors.affiliation: Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
authors.forename: Arianne
authors.initials: A
authors.lastname: Sweeting
authors.affiliation: Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Department of Obstetrics and Gynaecology, John Hunter Hospital, Newcastle, NSW, Australia.
authors.forename: Felicity
authors.initials: F
authors.lastname: Park
authors.affiliation: Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Department of High Risk Obstetrics, Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address: jon.hyett@sswahs.nsw.gov.au.
authors.forename: Jon
authors.initials: J
authors.lastname: Hyett
mesh_terms: D015415:Biomarkers / Q000097:blood; D003661:Decision Support Techniques; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D018570:Risk Assessment; D013577:Syndrome
chemical_list: D015415:Biomarkers
keywords: first-trimester pregnancy; gestational diabetes; pre-eclampsia; screening