title: Bioactive compounds from Holothuria atra of Indian ocean.
abstract: The sea cucumber (Holothuria atra) extracts have been evaluated for the presence of bioactive compounds and various biological activities. The methanol extracts showed anti proliferative activities against the Hela and MCF-7 cell lines. Similarly the inhibitory effects of Herpes simplex virus 1 and 2 cells were detected using the plaque reduction assay. The extracts of H. atra were purified using the silica gel column chromatography. The active fractions collected were observed for antimicrobial activity. The GC-MS analysis showed the availability of 59 compounds. The active bioactive compounds found in the H. atra were analyzed and their structure was identified using the (1)HNMR and (13)C NMR experiments.
authors.affiliation: Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari District, Tamil Nadu 629502 India.
authors.forename: Devaraj Isaac
authors.initials: DI
authors.lastname: Dhinakaran
authors.affiliation: Marine Biotechnology Laboratory, Central Marine Fisheries Research Institute, Vizhinjam, 695521 Thiruvananthapuram, Kerala India.
authors.forename: Aaron Premnath
authors.initials: AP
authors.lastname: Lipton
keywords: Bioactive compounds; Cell lines Herpes simplex virus MCF-7; Holothuria atra