title: The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Niels
authors.initials: N
authors.lastname: Weinhold
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Tobias
authors.initials: T
authors.lastname: Meissner
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Johnson
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Seckinger
authors.affiliation: INSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Moreaux
authors.affiliation: German Cancer Research Center, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.
authors.forename: Bowang
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Nickel
authors.affiliation: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chubb
authors.affiliation: Haematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Rawstron
authors.affiliation: Haematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK.
authors.forename: Chi
authors.initials: C
authors.lastname: Doughty
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Nasrin B
authors.initials: NB
authors.lastname: Dahir
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Dil B
authors.initials: DB
authors.lastname: Begum
authors.affiliation: Department of Haematology, University College London Hospital, UK.
authors.forename: Kwee
authors.initials: K
authors.lastname: Young
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Walker
authors.affiliation: Institute of Human Genetics, University of Bonn, Germany Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland.
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.affiliation: Institute of Human Genetics, University of Bonn, Germany Department of Genomics, Life & Brain Center, University of Bonn, Germany.
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Nöthen
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Faith E
authors.initials: FE
authors.lastname: Davies
authors.affiliation: INSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Klein
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.affiliation: Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Morgan
authors.affiliation: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany dirk.hose@med.uni-heidelberg.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hose
authors.affiliation: German Cancer Research Center, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
mesh_terms: D000368:Aged; D000483:Alleles; D001665:Binding Sites; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D040641:Quantitative Trait Loci; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D000099218:Interferon Regulatory Factor-4
chemical_list: D050835:Interferon Regulatory Factors; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; D000099218:Interferon Regulatory Factor-4; C513450:CDCA7L protein, human; C489427:MYC protein, human
keywords: eQTL; multiple myeloma; risk; single nucleotide polymorphism