title: Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates.
abstract: OBJECTIVE
  Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable on 3 Tesla MRI.
  
  
  METHODS
  We evaluated CMIs on 3 Tesla MRI in a population-based cohort of 194 nondemented older people (72-80 years) with systolic hypertension. Using a case-control design, participants with and without CMIs were compared on age, sex, cardiovascular risk factors, and white matter hyperintensity volume.
  
  
  RESULTS
  We identified 23 CMIs in 12 participants (6%). CMIs were associated with older age, higher diastolic blood pressure, and a history of recent stroke. There was a trend for a higher white matter hyperintensity volume in participants with CMIs.
  
  
  CONCLUSIONS
  We found an association of CMIs with clinical parameters, including age and cardiovascular risk factors. Although the prevalence of CMIs is relatively low, our results suggest that the study of CMIs in larger clinical studies is possible using 3 Tesla MRI. This opens the possibility of large-scale prospective investigation of the clinical relevance of CMIs in older people.
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.). j.vandalen@amc.nl.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: van Dalen
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Eva E M
authors.initials: EE
authors.lastname: Scuric
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Susanne J
authors.initials: SJ
authors.lastname: van Veluw
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Matthan W A
authors.initials: MW
authors.lastname: Caan
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Aart J
authors.initials: AJ
authors.lastname: Nederveen
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Willem A
authors.initials: WA
authors.lastname: van Gool
authors.affiliation: From the Department of Neurology (J.W.v.D., E.E.M.S., W.A.v.G., E.R.) and Department of Radiology (M.W.A.C., A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands (S.J.v.V., G.J.B.); and Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands (E.R.).
authors.forename: Edo
authors.initials: E
authors.lastname: Richard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D066127:White Matter / Q000473:pathology*
keywords: infarction; magnetic resonance imaging; stroke