title: Palladium-catalyzed ortho-selective C–H fluorination of oxalyl amide-protected benzylamines.
abstract: A novel and efficient synthetic method for o-fluorobenzylamines via palladium catalyst using an easily accessible oxalyl amide as directing group has been developed. The cheap N-fluorobenzenesulfonimide could be used as an effective [F+] source and t-amyl-OH as the solvent with Pd(OAc)2 as catalyst. Selective mono- or difluorination of oxalyl amide-protected benzylamine derivatives were achieved by modifying the reaction conditions, which presented an efficient method for the preparation of ortho-fluorinated benzylamines.
authors.forename: Changpeng
authors.initials: C
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000577:Amides / Q000737:chemistry*; D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D001596:Benzylamines; D006845:Hydrocarbons, Fluorinated; D010165:Palladium