title: CX-5461 inhibits RNA Pol I in blood cancers.
abstract: In a preclinical study, the investigational drug CX-5461, which blocks the protein RNA polymerase I, extended survival in mouse models of highly aggressive acute myeloid leukemia and multiple myeloma refractory to standard therapy.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D052160:Benzothiazoles / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D051379:Mice; D009287:Naphthyridines / Q000627:therapeutic use*; D012318:RNA Polymerase I / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D052160:Benzothiazoles; C557717:CX 5461; D009287:Naphthyridines; D012318:RNA Polymerase I