title: Coaxial electrohydrodynamic atomization: microparticles for drug delivery applications.
abstract: As cancer takes its toll on human health and well-being, standard treatment techniques such as chemotherapy and radiotherapy often fall short of ideal solutions. In particular, adverse side effects due to excess dosage and collateral damage to healthy cells as well as poor patient compliance due to multiple administrations continue to pose challenges in cancer treatment. Thus, the development of appropriately engineered drug delivery systems (DDS) for effective, controlled and sustained delivery of drugs is of interest for patient treatment. Moreover, the physiopathological characteristics of tumors play an essential role in the success of cancer treatment. Here, we present an overview of the application of double-walled microparticles for local drug delivery with particular focus on the electrohydrodynamic atomization (EHDA) technique and its fabrication challenges. The review highlights the importance of a combination of experimental data and computational simulations for the design of an optimal delivery system.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.
authors.forename: Pooya
authors.initials: P
authors.lastname: Davoodi
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore; School of Chemistry, Biology and Materials Engineering, Suzhou University of Science and Technology, Suzhou 215009, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.
authors.forename: Qingxing
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Yan
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.
authors.forename: Yen Wah
authors.initials: YW
authors.lastname: Tong
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.
authors.forename: M P
authors.initials: MP
authors.lastname: Srinivasan
authors.affiliation: Division of Neurology, Department of Medicine, National University Hospital, Tower Block Level 10, 1E Kent Ridge Road, Singapore 119228, Singapore.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Sharma
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore. Electronic address: chewch@nus.edu.sg.
authors.forename: Chi-Hwa
authors.initials: CH
authors.lastname: Wang
mesh_terms: D000336:Aerosols; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004867:Equipment Design; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D015233:Models, Statistical; D056004:Molecular Dynamics Simulation; D009330:Nebulizers and Vaporizers; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000336:Aerosols; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers
keywords: Biodegradable polymers; Coaxial EHDA; Core-shell microparticles; Drug delivery; Electrohydrodynamic atomization; Sustained release