title: Trends in survival outcomes of B-lineage acute lymphoblastic leukemia in elderly patients: analysis of Surveillance, Epidemiology, and End Results database.
abstract: B-lineage acute lymphoblastic leukemia (B-ALL) in the elderly population is generally considered to have a poor prognosis. It is unclear whether their survival has improved in the current era. Using the Surveillance, Epidemiology, and End Results database, we selected 717 elderly patients (age≥60) with B-ALL diagnosed between 1992 and 2011. Overall survival (OS) was compared based on their period of diagnosis and age. Patients in the age group 60-69 had an improvement in OS over time, both 1-year OS (49.4% in 2002-2011 vs. 33.1% in 1992-2001) and 5-year OS (20.4% in 2002-2011 vs. 8.1% in 1992-2001, p=0.002). Patients≥70 years had no significant improvement in 1-year OS or 5-year OS (5-year OS 5.5% in 1992-2001 vs. 9.7% in 2002-2011, p=0.326). Hence, there are discrepancies in the improvement of OS among elderly patients with B-ALL. Further focus of research in elderly patients with B-ALL is needed to improve their outcome.
authors.affiliation: a Division of Internal Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
authors.forename: Guru Subramanian
authors.initials: GS
authors.lastname: Guru Murthy
authors.affiliation: b Cochin Medical College , Kochi , India.|d John H. Stroger Jr. Hospital of Cook County , Chicago , IL , USA.
authors.forename: Raji
authors.initials: R
authors.lastname: Venkitachalam
authors.affiliation: c Division of Hematology/Oncology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health System , Little Rock , AR , USA.
authors.forename: Paulette
authors.initials: P
authors.lastname: Mehta
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000401:mortality*; D016016:Proportional Hazards Models; D012307:Risk Factors; D018426:SEER Program; D014481:United States / Q000453:epidemiology
keywords: Elderly; SEER; acute lymphoblastic leukemia; survival