title: The impact of obesity on pentraxin 3 and inflammatory milieu to acute aerobic exercise.
abstract: Pentraxin 3 (PTX3) has recently been linked to obesity-associated inflammation, serving as a cardioprotective modulator against cardiovascular disease (CVD). Aerobic exercise has been shown to enhance plasma PTX3 levels; however, the impact of obesity on PTX3 response to exercise remains unknown.
  
  
  OBJECTIVE
  Therefore, this study sought to examine whether obese subjects would have an attenuated plasma PTX3 response compared to normal-weight subjects following acute aerobic exercise. The relationship of plasma PTX3 with pro-inflammatory cytokines (IL-6 and TNF-α) was also examined.
  
  
  METHODS
  Twenty healthy subjects (10 obese [4 males and 6 females] and 10 normal-weight [4 males, 6 females]) performed 30min of continuous submaximal aerobic exercise.
  
  
  RESULTS
  At baseline, obese subjects exhibited approximately 40% lower plasma PTX3 and a 7-fold greater IL-6 concentration compared to normal-weight subjects. In response to exercise, no difference was observed in PTX3 or IL-6 as indicated by area-under-the-curve "with respect to increase" (AUCi) analyses. Furthermore, PTX3 AUCi was positively correlated with cardiorespiratory fitness levels (VO(2max)) (r=0.594, p=0.006), even after controlling for body mass index.
  
  
  CONCLUSIONS
  These findings suggest that in addition to obesity-associated complications, low cardiorespiratory fitness levels could impact exercise-induced PTX3 elevations, thereby potentially diminishing PTX3's effects of anti-inflammation and/or cardioprotection.
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL. Electronic address: aslusher@fau.edu.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Slusher
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL.
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Mock
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL.
authors.forename: Michael
authors.initials: M
authors.lastname: Whitehurst
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL.
authors.forename: Arun
authors.initials: A
authors.lastname: Maharaj
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL.
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001642:Bicycling; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D015536:Down-Regulation; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009043:Motor Activity; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism*; D009765:Obesity / Q000097:blood* / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D010101:Oxygen Consumption; D010809:Physical Fitness; D000683:Serum Amyloid P-Component / Q000032:analysis* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015854:Up-Regulation; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D015850:Interleukin-6; D000683:Serum Amyloid P-Component; D014409:Tumor Necrosis Factor-alpha; D000099153:Pentraxins; C508600:IL6 protein, human; C439524:TNF protein, human
keywords: Exercise; Interleukin-6; Obesity; Pentraxin 3; Tumor necrosis factor-alpha