title: Optical quality in central serous chorioretinopathy.
abstract: OBJECTIVE
  To assess optical quality and intraocular scattering using the Optical Quality Analysis System (OQAS) in central serous chorioretinopathy (CSC) and to determine the effects of retinal changes on optical quality.
  
  
  METHODS
  This was a prospective, case-control study. Participants were 29 patients with diagnosis of CSC. The control group consisted of the patients' unaffected eyes. Initial logMAR visual acuity, central macular thickness (by spectral domain optical coherence tomography), and optical quality parameters including modulation transfer function (MTF) cutoff frequency, Strehl (2-dimensional) ratio, and OQAS values at 100%, 20%, and 9% contrast levels were investigated. Objective scattering index (OSI) at 4.0-mm pupil size was assessed in both eyes by using the OQAS. After 3 months of treatment, which included observation and focal laser or injections of antivascular endothelial growth factor, every CSC-affected eye was followed. Main outcome measures were differences between clinical parameters of the CSC-affected eye and those of the control eye and changes in those parameters according to the clinical course of CSC over 3 months.
  
  
  RESULTS
  In CSC-affected eyes, the MTF cutoff was significantly reduced (P = 0.01), and OSI was significantly increased (P = 0.03). As macular thickness decreased, OSI decreased but did not become normalized compared to the control eye, nor was it statistically significantly correlated with central macular thickness change.
  
  
  CONCLUSIONS
  Retinal change affected optical quality and intraocular scatter. Therefore, when the severity of a cataract is assessed using the OQAS, retinal status should be considered when interpreting OQAS values.
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, Catholic University of Korea, Seoul, Korea HanGil Eye Hospital, Incheon, Korea.
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
authors.affiliation: HanGil Eye Hospital, Incheon, Korea.
authors.forename: Joonhong
authors.initials: J
authors.lastname: Sohn
authors.affiliation: HanGil Eye Hospital, Incheon, Korea Department of Optometry, Seoul National University of Science and Technology, Seoul, Korea.
authors.forename: Jong Gil
authors.initials: JG
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Kun
authors.initials: SK
authors.lastname: Chung
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D056910:Republic of Korea; D012542:Scattering, Radiation; D014792:Visual Acuity / Q000502:physiology
keywords: central serous chorioretinopathy; double-pass system; optical quality; retinal sensitivity