title: Electrochemical behavior and voltammetric determination of acetaminophen based on glassy carbon electrodes modified with poly(4-aminobenzoic acid)/electrochemically reduced graphene oxide composite films.
abstract: Poly(4-aminobenzoic acid)/electrochemically reduced graphene oxide composite film modified glassy carbon electrodes (4-ABA/ERGO/GCEs) were fabricated by a two-step electrochemical method. The electrochemical behavior of acetaminophen at the modified electrode was investigated by means of cyclic voltammetry. The results indicated that 4-ABA/ERGO composite films possessed excellent electrocatalytic activity towards the oxidation of acetaminophen. The electrochemical reaction of acetaminophen at 4-ABA/ERGO/GCE is proved to be a surface-controlled process involving the same number of protons and electrons. The voltammetric determination of acetaminophen performed with the 4-ABA/ERGO modified electrode presents a good linearity in the range of 0.1-65 μM with a low detection limit of 0.01 μM (S/N=3). In the case of using the 4-ABA/ERGO/GCE, acetaminophen and dopamine can be simultaneously determined without mutual interference. Furthermore, the 4-ABA/ERGO/GCE has good reproducibility and stability, and can be used to determine acetaminophen in tablets.
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; School of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250013, China.
authors.forename: Wencai
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Gao
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. Electronic address: hyma@sdu.edu.cn.
authors.forename: Houyi
authors.initials: H
authors.lastname: Ma
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry; D000082:Acetaminophen / Q000032:analysis*; D002244:Carbon / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets / Q000737:chemistry
chemical_list: D010087:Oxides; D011108:Polymers; D013607:Tablets; D000082:Acetaminophen; D002244:Carbon; D006108:Graphite; D010129:4-Aminobenzoic Acid; D004298:Dopamine
keywords: Acetaminophen; Electroanalysis; Graphene; Poly(4-aminobenzoic acid); Voltammetric determination