title: Comparison between adults and children with Henoch-Schönlein purpura nephritis.
abstract: BACKGROUND
  Henoch-Schönlein purpura (HSP) mainly affects children, but age is also thought to be an important prognostic factor. Kidney involvement is a major cause of mortality in HSP patients. The purpose of this study was to analyze the clinicopathological correlations between adults and children.
  
  
  METHODS
  A total of 208 children and 75 adult patients with HSP nephritis (HSPN) were evaluated. All patients underwent a renal biopsy.
  
  
  RESULTS
  Extra-renal symptoms (arthritis and abdominal pain) were more common in the pediatric patient group than in the adult group (P < 0.05), but renal symptoms (edema and hypertension) were relatively rare (P < 0.05). A significant positive correlation was noted between pathological type and clinical type (P < 0.01). Pathological activity was positively related to renal failure, abdominal pain, microscopic hematuria, hypertension, and proteinuria (P < 0.05). Pathological chronicity was positively associated with age, duration of follow-up since the onset of palpable purpura, renal failure, lower extremity edema, hypertension, and proteinuria (P < 0.05).
  
  
  CONCLUSIONS
  Various clinicopathological differences exist between children and adults with HSPN. Massive proteinuria, renal failure, and abdominal pain usually correlated with severe pathology. Renal biopsy should be performed in both pediatric and adult HSPN patients with repeated hematuria and/or consistent minimal proteinuria.
authors.affiliation: Department of Nephrology, First Affiliated Hospital of Zhengzhou University, No.1, JianShe East Road, Zhengzhou, Henan Province, The People's Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Lu
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.forename: Wenming
authors.initials: W
authors.lastname: Yuan
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhangsuo
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhanzheng
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult