title: Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis.
abstract: Growing evidence suggests that aberration of the DNA repair pathway significantly contributes to tumorigenesis. Single-nucleotide polymorphisms in DNA repair-related genes such as WRN have been implicated in cancer risk. However, the results of published studies remain inconclusive. Therefore, we performed a meta-analysis of all available and relevant published studies to clarify the role of this polymorphism in cancer. We performed a computerized search of PubMed for publications on WRN Cys1367Arg (T>C) polymorphism and cancer risk and analyzed the genotype data. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, heterogeneity test, cumulative meta-analysis, and bias assessment were performed using STATA software 11.0. No association was found between WRN Cys1367Arg (T>C) polymorphism and cancer risk in all genetic models. When stratified by cancer type, results showed that this polymorphism increased the risk of breast cancer (2CC+CT vs 2TT+CT: perallele OR = 1.14, 95% CI = 1.03-1.26, P trend = .012; CC vs TT: OR = 1.43, 95% CI = 1.04-1.95, P value = .026; CC+CT vs TT: OR = 1.14, 95% CI = 1.02-1.28, P value = .027). In another analysis stratified by ethnicity, WRN Cys1367Arg (T>C) polymorphism was significantly associated with cancer susceptibility in Europeans (2CC+CT vs 2TT+CT: perallele OR = 1.09, 95% CI = 1.00-1.19, P trend = .042; CT vs TT: OR = 1.13, 95% CI = 1.01-1.27, P value = .032; and CC+CT vs TT: OR = 1.13, 95% CI = 1.02-1.26, P value = .025). Our study suggests that WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations.
authors.affiliation: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Hematology of Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China.
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China jingdehua1963@163.com.
authors.forename: Dehua
authors.initials: D
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D005090:Exodeoxyribonucleases / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020125:Mutation, Missense; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053484:RecQ Helicases / Q000235:genetics*; D012306:Risk; D000071657:Werner Syndrome Helicase
chemical_list: D005090:Exodeoxyribonucleases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase
keywords: Cys1367Arg; WRN; cancer; meta-analysis