title: The utility of protein and mRNA correlation.
abstract: Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.
authors.affiliation: Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99354, USA. Electronic address: samuel.payne@pnnl.gov.
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Payne
mesh_terms: D019295:Computational Biology; D016678:Genome; D040901:Proteomics; D049490:Systems Biology; D059467:Transcriptome
keywords: bioinformatics; proteomics; systems biology; transcriptomics