title: A novel non-surgical, minimally invasive technique for parathyroid autotransplantation: a case report.
abstract: We present a case report of intramuscular autotransplantation of the parathyroid cell suspension acquired after total parathyroidectomy. A 15-yr-old female patient who had been undergoing hemodialysis due to chronic renal failure for eight yr was diagnosed with secondary hyperthyroidism and subsequently underwent total parathyroidectomy. The parathyroid cells were acquired from the resected tissues, processed through isolation and cultivation phases, and counted using a cell counter. A total of two million cells were injected into the left deltoid muscle using a 22-gauge needle. After surgery, five and 10 million cells were injected in the fifth and 12 week, respectively. The desired serum levels of parathyroid hormones and calcium were not achieved after the first two transplantations. In addition, there was no regression in the patient's symptoms. However, at four wk after the third transplantation, serum parathyroid hormone level did not decrease to <3 pg/mL, the patient was asymptomatic, and the oral treatment was stopped. Our findings indicate that this new technique is applicable because it is minimally invasive, and it can be easily repeated.
authors.affiliation: Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Aysan
authors.forename: Ulkan
authors.initials: U
authors.lastname: Kilic
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gok
authors.forename: Burcugul
authors.initials: B
authors.lastname: Altug
authors.forename: Cilem
authors.initials: C
authors.lastname: Ercan
authors.forename: Ufuk Oguz
authors.initials: UO
authors.lastname: Idiz
authors.forename: Cemile
authors.initials: C
authors.lastname: Kesgin
authors.forename: Mahmut
authors.initials: M
authors.lastname: Muslumanoglu
mesh_terms: D000293:Adolescent; D002118:Calcium / Q000378:metabolism; D017690:Cell Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D019060:Minimally Invasive Surgical Procedures; D010280:Parathyroid Glands / Q000166:cytology* / Q000637:transplantation; D010281:Parathyroid Hormone / Q000378:metabolism; D016105:Parathyroidectomy; D006435:Renal Dialysis; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium
keywords: autotransplantation; invasive; minimally; non-surgical; parathyroid