title: Statistical significance in the selection of the regions of interest for Parkinson brain image processing.
abstract: This paper presents the analysis of the statistical significance in the selection of the ROI for the discriminant analysis of brain images to identify Parkinson patients or subjects without any pathology. The particular features and brain functional patterns of the Parkinson's disease cause that there are regions that conveniently reveal the presence of the pathology, in this case mainly the striatum region. The selection of the brain mask makes incidence in two main aspects: the selection of the region of interest (striatum and surrounding area) for the analysis, but also the selection of the region without significance, which is the reference area for the intensity normalization, previous to the analysis. This work studies the statistical significance in the selection of ROIs in 3D brain images for Parkinson, depending on the objective to be achieved in the posterior analysis process.
authors.affiliation: University of Granada - CITIC, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Padilla
authors.affiliation: University of Granada - CITIC, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Ramírez
authors.affiliation: University of Granada - CITIC, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Górriz
authors.affiliation: University of Granada - CITIC, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Salas-González
authors.affiliation: University of Granada - CITIC, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alvarez-Illán
mesh_terms: D000465:Algorithms; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000473:pathology; D003627:Data Interpretation, Statistical; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D009662:Nortropanes; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D009662:Nortropanes; D019275:Radiopharmaceuticals; C519528:ioflupane