title: Evaluation of correlation between high serum-ascites albumin gradient and the upper gastrointestinal endoscopic parameters in children presenting with portal hypertension with ascites.
abstract: Portal hypertension which usually leads to bleeding from oesophageal varices in children remain a difficult medical problem. The upper gastrointestinal endoscopy is currently considered as the best reliable method to diagnose oesophageal varices in portal hypertension. But endoscopic screening is an invasive procedure and is not easily available even in tertiary health care facilities of Bangladesh till now. Therefore an alternative noninvasive indicator is being looked for the diagnosis of portal hypertension. Patients with serum ascites albumin gradient (SAAG) values ≥1.1gm/dl have recently found to have presence of portal hypertension. The study was carried out to set up a diagnostic value of SAAG for the prediction of portal hypertensive changes (oesophageal and gastric varices, gastropathy) of upper gastrointestinal endoscopy in children. This cross sectional study was conducted at the Department of Paediatric Gastroenterology and Nutrition of Bangabandhu Sheikh Mujib Medical University. A total of 30 cases of portal hypertension were studied from November 2008 to February 2010. Oesophageal varices were found in 86.7% of cases. Significant association was found between high SAAG values and presence of oesophageal varices. Frequencies of oesophageal varices increased as the SAAG values increased. The cut off point of SAAG value was found to be 1.55gm/dl for the presence of oesophageal varices where sensitivity and specificity were found 84.6% and 100 % respectively. From this study, it can be concluded that SAAG value 1.6gm/dl is an indicator of portal hypertensive changes especially oesophageal varices in children.
authors.affiliation: Dr Nazma Begum, Assistant Professor, Department of Paediatrics, Shaheed Suhrawardy Medical College and Hospital, Dhaka, Bangladesh.
authors.forename: N
authors.initials: N
authors.lastname: Begum
authors.forename: A
authors.initials: A
authors.lastname: Afroza
authors.forename: B M
authors.initials: BM
authors.lastname: Karim
mesh_terms: D001201:Ascites / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D001202:Ascitic Fluid / Q000378:metabolism*; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis*; D012720:Severity of Illness Index; D013223:Statistics as Topic
chemical_list: D012709:Serum Albumin