title: Can we predict the outcome of 595-nm wavelength pulsed dye laser therapy on capillary vascular malformations from the first beginning: a pilot study of efficacy co-related factors in 686 Chinese patients.
abstract: Currently, there are no standardized, objective, and clinically applicable methods to predict the outcome of pulsed dye laser (PDL) therapy on capillary vascular malformation (CVM) patients. The introduction of a method that can predict the outcome prior to treatment will be valuable for both the patients and the doctors. In this study, the authors treated CVM with 595-nm wavelength PDL in Chinese patients (n = 686) and analyzed the efficacy of treatment and complications retrospectively in a 5-year period. Nearly 18 % of patients (n = 122) had 76 % or more clearing of lesions; over 52 % of patients (n = 360) had more than 50 % of clearing. The lesions in head and neck region had the best effective rate (58.3 %), followed by trunk (42.9 %) and extremities (35.6 %). The efficacy of PDL therapy is related to age, type, and location of lesions. Fifty-seven patients (8.3 %) had complications, including 2.0 % blistering (n = 14), 4.5 % hyperpigmentation (n = 31), 1.3 % hypopigmentation (n = 9), and 0.4 % hypertrophic scarring (n = 3). Based on these preliminary data, the authors established a standardized, objective, and clinically applicable equation that may be applied to predict the efficacy of 595 nm PDL therapy on a newly diagnosed Chinese CVM patients based on the age, type, and location of lesions.
authors.affiliation: Division of Plastic and Reconstructive Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China, liuxiangxia@gmail.com.
authors.forename: Xiangxia
authors.initials: X
authors.lastname: Liu
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Fan
authors.forename: Jiexin
authors.initials: J
authors.lastname: Huang
authors.forename: Ruixi
authors.initials: R
authors.lastname: Zeng
authors.forename: Guangling
authors.initials: G
authors.lastname: Cao
authors.forename: Mukai
authors.initials: M
authors.lastname: Chen
authors.forename: Wenna
authors.initials: W
authors.lastname: Chen
authors.forename: Jinming
authors.initials: J
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D054025:Lasers, Dye; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012372:ROC Curve; D012189:Retrospective Studies; D016896:Treatment Outcome; D054079:Vascular Malformations / Q000473:pathology / Q000601:surgery*; D055815:Young Adult