title: MiRNAs as potential molecular targets in heart failure.
abstract: Pathogenesis of heart diseases is associated with an altered expression profile of hundreds of genes. miRNAs are a newly identified layer of gene regulation operating at the post-transcriptional level by pairing to complementary base sequences in target mRNAs. Genetic data have identified the roles of miRNAs in basic pathological processes associated with heart failure: apoptosis, fibrosis, myocardial hypertrophy and cardiac remodeling. Many reports demonstrated that aberrantly expressed miRNAs and their modulation have effects on cardiac insufficiency. Here, we overview the advances in miRNAs as potential targets in the modulation of the heart failure phenotype. miRNA-based therapy holds great promise as a future strategy for treating heart diseases and identifying emerging signaling pathways responsible for the progression of heart failure.
authors.affiliation: Sanger Heart & Vascular Institute, Carolinas HealthCare System, Charlotte, NC, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Katz
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Fargnoli
authors.forename: Richard D
authors.initials: RD
authors.lastname: Williams
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Kendle
authors.forename: Nury M
authors.initials: NM
authors.lastname: Steuerwald
authors.forename: Charles R
authors.initials: CR
authors.lastname: Bridges
mesh_terms: D006333:Heart Failure / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D035683:MicroRNAs
keywords: apoptosis; cardiac remodeling; fibrosis; heart failure; microRNAs; myocardial hypertrophy