title: Comprehensive quality of life outcomes for pediatric patients undergoing endoscopic sinus surgery.
abstract: Limited quality of life data exist for pediatric chronic rhinosinusitis (CRS) patients undergoing endoscopic sinus surgery (ESS). Further exploration of the following areas will enhance understanding and support clinical decision-making: baseline and post-ESS general and disease-specific quality of life, parent vs. child report, and correlation of nasal endoscopy to sinus CT scores.
  
  
  
  A prospective cohort study evaluated CRS patients age 5-18 undergoing ESS. Surveys were completed at two timepoints: (1) pre-ESS and (2) 30-90 days post-ESS, with parents completing general (PedsQLTM) and CRS-specific (SNOT-16 and SN-5) quality of life surveys and children completing PedsQLTM and SNOT-16 surveys. Preoperative Lund-Kennedy nasal endoscopy and Lund-Mackay sinus CT scores were calculated. Where appropriate, outcomes were stratified by cystic fibrosis status.
  
  
  
  Impaired preoperative general quality of life was evidenced by parent proxy-report of PedsQLTM scores in 10 cystic fibrosis and 11 non-CF patients. ESS was associated with decreased sinus symptoms at 1-3 months postoperatively with SN-5 change scores of -1.85 and -2.2, in CF and non-CF patients, respectively. Parents reported worse CRS symptoms via higher preoperative SNOT-16 scores than their children did. Nasal endoscopy and sinus CT scores correlated with a Spearman correlation coefficient of 0.51. Scores not reaching statistical significance included CF-related CRS SNOT-16 change scores and PedsQLTM general quality of life change scores.
  
  
  
  In pediatric patients with CRS electing ESS, general quality of life is impaired preoperatively and sinus symptoms improve significantly 1-3 months after sinus surgery. Parents report statistically worse CRS symptom scores than their children do. Nasal endoscopy scores in this cohort correlated with sinus CT scores.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Taylor
authors.forename: Justin D
authors.initials: JD
authors.lastname: Miller
authors.forename: Austin S
authors.initials: AS
authors.lastname: Rose
authors.forename: Amelia F
authors.initials: AF
authors.lastname: Drake
authors.forename: Carlton J
authors.initials: CJ
authors.lastname: Zdanski
authors.forename: Brent A
authors.initials: BA
authors.lastname: Senior
authors.forename: Charles S
authors.initials: CS
authors.lastname: Ebert
authors.forename: Adam M
authors.initials: AM
authors.lastname: Zanation
mesh_terms: D003550:Cystic Fibrosis / Q000473:pathology*; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D010256:Paranasal Sinuses / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D011788:Quality of Life; D012220:Rhinitis / Q000601:surgery*