title: Aminoquinoline based highly sensitive fluorescent sensor for lead(II) and aluminum(III) and its application in live cell imaging.
abstract: We have synthesized a new probe 5-((anthracen-9-ylmethylene) amino)quinolin-10-ol (ANQ) based on anthracene platform. The probe was tested for its sensing behavior toward heavy metal ions Hg(2+), Pb(2+), light metal Al(3+) ion, alkali, alkaline earth, and transition metal ions by UV-visible and fluorescent techniques in ACN/H2O mixture buffered with HEPES (pH 7.4). It shows high selectivity toward sensing Pb(2+)/Al(3+) metal ions. Importantly, 10-fold and 5- fold fluorescence enhancement at 429 nm was observed for probe upon complexation with Pb(2+) and Al(3+) ions, respectively. This fluorescence enhancement is attributable to the prevention of photoinduced electron transfer. The photonic studies indicate that the probe can be adopted as a sensitive fluorescent chemosensor for Pb(2+) and Al(3+) ions.
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, India.
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Anand
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, India.
authors.forename: Gandhi
authors.initials: G
authors.lastname: Sivaraman
authors.affiliation: School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India. Electronic address: mahesh.a06@gmail.com.
authors.forename: Ayyavu
authors.initials: A
authors.lastname: Mahesh
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625021, India. Electronic address: dcmku123@gmail.com.
authors.forename: Duraisamy
authors.initials: D
authors.lastname: Chellappa
mesh_terms: D000535:Aluminum / Q000032:analysis*; D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000873:Anthracenes / Q000138:chemical synthesis / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D007854:Lead / Q000032:analysis*; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence
chemical_list: C000599942:5-((anthracen-9-ylmethylene)amino)quinolin-10-ol; D000634:Aminoquinolines; D000873:Anthracenes; D005456:Fluorescent Dyes; D007477:Ions; D007854:Lead; D000535:Aluminum
keywords: Anthracene; Lead(II); Live cell imaging; Time dependent-density functional theory; Turn-on