title: Absence of the memory response to encephalitogen following intergender adoptively transferred experimental autoimmune encephalomyelitis.
abstract: Animals that have recovered from adoptively transferred EAE develop clinical disease signs 2-3days earlier than controls when challenged with encephalitogen. This may be due to the reactivation of donor-derived memory cells or stimulation of recipient-derived memory cells primed during the adoptive disease episode. In order to determine the origin of the memory cell subset, we used a donor-recipient model where donor cells are rejected in recipients following a course of adoptively transferred disease. Our results suggest the early onset of disease seen in recipients recovered from adoptively transferred disease and challenged with encephalitogen is due to the sustained presence of donor-derived memory cells.
authors.affiliation: Immunology Research Group, Veterans Affairs Medical Center, Portland, OR 97239, United States; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, United States. Electronic address: archie.bouwer@va.gov.
authors.forename: H G
authors.initials: HG
authors.lastname: Archie Bouwer
authors.affiliation: Immunology Research Group, Veterans Affairs Medical Center, Portland, OR 97239, United States; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, United States; Center for Regenerative Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Gregory
authors.affiliation: Immunology Research Group, Veterans Affairs Medical Center, Portland, OR 97239, United States.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Wegmann
authors.affiliation: Immunology Research Group, Veterans Affairs Medical Center, Portland, OR 97239, United States; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, United States.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hinrichs
mesh_terms: D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000628:therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D007156:Immunologic Memory / Q000502:physiology*; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D004676:Myelin Basic Protein; D005620:Freund's Adjuvant
keywords: Adoptive transfer; Experimental autoimmune encephalomyelitis; Memory cells