title: Recurrent laryngeal papillomatosis with oesophageal involvement in a 2 year old boy: successful treatment with the quadrivalent human papillomatosis vaccine.
abstract: Authors present a case report of a 2-year-old boy with recurrent laryngeal papillomatosis with oesophageal involvement due to human papilloma virus types 6 and 11, who needed surgical treatment every 4-6 weeks, altogether 11 times. After detailed immunological evaluation of basic immunological parameters, and in vitro detection of good responses to routine childhood immunization, a therapeutic vaccination has been decided with a 4-valent HPV vaccine. Following the third vaccine dose both laryngeal and oesophageal lesions disappeared completely, and for 2 years follow-up no papillomas could be detected. Vaccination could be a promising method in the treatment of RRP in children.
authors.affiliation: National Centre for Immunization at Szent László Hospital for Infectious Diseases, National Institute of Child Health, Budapest, Hungary.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Mészner
authors.affiliation: National Centre for Epidemiology, Department of Virology, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Jankovics
authors.affiliation: Heim Pál Children's Hospital, Endoscopy Laboratory, Budapest, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Nagy
authors.affiliation: Pécs University, Ear-Nose-Throat-, Head-Neck Surgery Department University of Pécs, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Gerlinger
authors.affiliation: Heim Pál Children's Hospital, Ear-Nose-Throat Department, Budapest, Hungary. Electronic address: katonagbor@gmail.com.
authors.forename: Gábor
authors.initials: G
authors.lastname: Katona
mesh_terms: D002675:Child, Preschool; D052140:Human papillomavirus 11 / Q000276:immunology; D052163:Human papillomavirus 6 / Q000276:immunology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy* / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy* / Q000821:virology; D010212:Papilloma / Q000628:therapy* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications* / Q000276:immunology; D053918:Papillomavirus Vaccines
chemical_list: D053918:Papillomavirus Vaccines
keywords: Children; Quadrivalent human papilloma vaccine; Recurrent oesophageal papillomatosis; Recurrent respiratory papillomatosis