title: Fabrication of a nanofibrous mat with a human skin pattern.
abstract: A number of studies on skin tissue regeneration and wound healing have been conducted. Electrospun nanofibers have numerous advantages for use in wound healing dressings. Here, we present an electrospinning method for alteration of the surface morphological properties of electrospun mats because most previous studies focused on the materials used or the introduction of bioactive healing agents. In this study, a micromachined human skin pattern mold was used as a collector in an electrospinning setup to replicate the pattern onto the surface of the electrospun mat. We demonstrated the successful fabrication of a nanofibrous mat with a human skin pattern. To verify its suitability for wound healing, a 14-day in vitro cell culture was carried out. The results indicated that the fabricated mat not only induces equivalent cell viability to the conventional electrospun mat, but also exhibits guidance of cells along the skin pattern without significant deterioration of pattern geometry.
authors.affiliation: Department of Mechanical Engineering, Korea Polytechnic University , Gyeonggi 429-793, South Korea.
authors.forename: Jeong Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Jinah
authors.initials: J
authors.lastname: Jang
authors.forename: Young Hun
authors.initials: YH
authors.lastname: Jeong
authors.forename: Tae Jo
authors.initials: TJ
authors.lastname: Ko
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Cho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004560:Electricity; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods*; D012867:Skin / Q000166:cytology*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials