title: Genome-wide redistribution of BRD4 binding sites in transformation resistant cells.
abstract: Hutchinson-Gilford progeria syndrome (HGPS) patients do not develop cancer despite a significant accumulation of DNA damage in their cells. We have recently reported that HGPS cells are refractory to experimental oncogenic transformation and we identified the bromodomain-containing 4 protein (BRD4) as a mediator of the transformation resistance. ChIP-sequencing experiments revealed distinct genome-wide binding patterns for BRD4 in HGPS cells when compared to control wild type cells. Here we provide a detailed description of the ChIP-seq dataset (NCBI GEO accession number GSE61325), the specific and common BRD4 binding sites between HGPS and control cells, and the data analysis procedure associated with the publication by Fernandez et al., 2014 in Cell Reports 9, 248-260 [1].
authors.affiliation: CCRIFX, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Han
authors.initials: H
authors.lastname: Si
authors.affiliation: Cell Biology of Genomes Group, LRBGE, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Paola
authors.initials: P
authors.lastname: Scaffidi
authors.affiliation: CCRIFX, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Anand
authors.initials: A
authors.lastname: Merchant
authors.affiliation: OSTR, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Maggie
authors.initials: M
authors.lastname: Cam
authors.affiliation: CCRIFX, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Eric
authors.initials: E
authors.lastname: Stahlberg
authors.affiliation: Cell Biology of Genomes Group, LRBGE, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
authors.affiliation: Cell Biology of Genomes Group, LRBGE, National Cancer Institute, NIH, Bethesda, Maryland, 20892.
authors.forename: Patricia
authors.initials: P
authors.lastname: Fernandez