title: The usage of micellar extraction for analysis of fluvastatin in water and wastewater samples.
abstract: This work illustrates the development of new procedures for the isolation and preconcentration of fluvastatin (FLU) from aqueous solutions. Micellar extraction (ME) combined with high performance liquid chromatography (HPLC-UV) has been successfully applied for this purpose. It was found that the analyte created micelle with anionic sodium dodecylsulfate (SDS) and/or with the binary mixture of surfactants nonionic triton X114 (TX114) and cationic tetra-n-butyloammonium bromide (TBAB). The optimal analytical conditions for the proposed extraction procedures (solution pH, concentration of surfactants, centrifugation time and electrolyte type) were ascertained. The calibration curves were recorded. The linearity ranges for FLU, isolated by SDS and the mixture of TX114/TBAB, were 0.21-28.79 μg mL(-1) and 0.21-16.45 μg mL(-1) with limit of detection (LOD) 0.19 μg mL(-1) and 0.14 μg mL(-1), respectively. The recoveries afforded by the proposed methods were high, approximately 97%. These preconcentration procedures were applied for the isolation of the statin from water and wastewater samples taken from the local rivers and wastewater treatment plants.
authors.affiliation: Institute of Chemistry, University of Białystok, ul. Hurtowa 1, 15-399 Białystok, Poland. Electronic address: martah@uwb.edu.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Hryniewicka
authors.affiliation: Institute of Chemistry, University of Białystok, ul. Hurtowa 1, 15-399 Białystok, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Starczewska
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005229:Fatty Acids, Monounsaturated / Q000032:analysis*; D000077340:Fluvastatin; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000032:analysis*; D057230:Limit of Detection; D008823:Micelles; D045483:Rivers; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013501:Surface-Active Agents / Q000737:chemistry; D062065:Wastewater / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D005229:Fatty Acids, Monounsaturated; D000077340:Fluvastatin; D007211:Indoles; D008823:Micelles; D013501:Surface-Active Agents; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: Fluvastatin; Micellar extraction; Sodium dodecylsulfate; Tetra-n-butyloammonium bromide; Triton X114