title: [Dopamine-NO interaction in the nucleus accumbens during stress-induced inhibition of expliratory behavior].
abstract: In Sprague-Dawley rats by means of in vivo microdialysis it was shown that stress, evoked by conditioned fear response acquisition, resulted in inhibition of exploratory behavior and produced a reduction of exploration-induced rise in extracellular levels of citrulline (an NO co-product) in the nucleus accumbens which were observed 24 hours after the stress. Intra-accumbal infusion of dopamine D2 receptor antagonist raclopride (10 μM), made after the conditioned fear response acquisition, in 24 hours after the infusion, restore the exploratory behavior and exploration-induced rise of extracellular levels of citrulline in this brain area. The data obtained indicate for the first time that stress-induced inhibition of the exploratory behavior might be mediated by inhibition of the nucleus accumbens nitrergic system occurring under the control of D2 receptors of this brain area.
authors.forename: N B
authors.initials: NB
authors.lastname: Saulskaya
authors.forename: P V
authors.initials: PV
authors.lastname: Sudorgina
mesh_terms: D000818:Animals; D002956:Citrulline / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology*; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D017551:Microdialysis; D009569:Nitric Oxide / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000503:physiopathology; D020891:Raclopride / Q000008:administration & dosage; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000378:metabolism
chemical_list: D017448:Receptors, Dopamine D2; D002956:Citrulline; D009569:Nitric Oxide; D020891:Raclopride; D004298:Dopamine