title: Biomarkers for cancer-related fatigue and adverse reactions to chemotherapy in lung cancer patients.
abstract: This study was conducted to investigate the biomarkers that appear to be correlated with cancer-related fatigue (CRF) and the adverse reactions (ADRs) to chemotherapy. A total of 100 lung cancer patients were selected and CRF prior to and following chemotherapy was evaluated. The plasma levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1 and the level of 17-hydroxycorticosteroid (17-OHCS) in the urine were analyzed and correlated with CRF and the ADRs associated with chemotherapy. The incidence of CRF was found to be 88.0% and ADRs following chemotherapy occurred in 15.0% of the patients. An increase in the TNF-α and IL-1 levels was detected in patients with CRF. The level of 17-OHCS in the urine was found to be elevated in cases that experienced ADRs following chemotherapy. In conclusion, CRF is closely correlated with increased plasma levels of TNF-α and IL-1. Furthermore, an abnormally elevated 17-OHCS level in the urine may be an important indicator predicting ADR development following chemotherapy.
authors.affiliation: Departments of Pharmacy, Shantou, Guangdong 505031, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Sha
authors.affiliation: Departments of Clinical Laboratory Medicine, Shantou, Guangdong 505031, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhuang
authors.affiliation: Departments of Gynecological Oncology, Shantou, Guangdong 505031, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Departments of IT, and Shantou, Guangdong 505031, P.R. China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Departments of Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China.
authors.forename: Yuxian
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Departments of Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China.
authors.forename: Shengqi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Departments of Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Departments of Pharmacy, Shantou, Guangdong 505031, P.R. China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Departments of Pharmacy, Shantou, Guangdong 505031, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Departments of Pharmacy, Shantou, Guangdong 505031, P.R. China.
authors.forename: Jieting
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Departments of Pharmacy, Shantou, Guangdong 505031, P.R. China.
authors.forename: Shuyao
authors.initials: S
authors.lastname: Zhang
keywords: 17-hydroxycorticosteroid; adverse reactions to chemotherapy; cancer-related fatigue; interleukin 1; lung cancer; tumor necrosis factor-α