title: Association between advanced oxidation protein products and 5-year mortality risk among amazon riparian elderly population.
abstract: Proteins are important targets of several modifications caused by oxidative stress, leading to structural changes and consequently partial or total loss of their functions. The oxidized proteins include advanced oxidation protein products (AOPP) derived from oxidation-modified albumin, as well as fibrinogen and lipoproteins. An increase in AOPP levels indicates an oxidative stress state and the presence of coexisting inflammation. Several investigations have also suggested an association between high AOPP levels and aging-related diseases. However, the link between elevated AOPP levels and elderly mortality risk has not yet been investigated. Here, we report on a 5-year longitudinal study that investigated the potential association between AOPP levels and mortality using a population-based representative sample of riparian elders living in Brazilian Amazon region (Maués-AM). Age, sex, socioeconomic and cultural conditions, chronic morbidities, polypharmacy, and previous morbidities were also tested as potential confounders. The AOPP levels were measured in 540 (84.78%) individuals, all of whom were followed over a 5-year period in order to establish the mortality rate. Within this study period, 74 (13.7%) elders died and 466 (86.3%) survived. The AOPP levels were higher among the elders who died within the 5-year period (46.27 ± 40.6 mmol/L) compared with those who survived (36.79 ± 20.84 mmol/L) (p = 0.002). The analysis confirmed the link between high AOPP levels and mortality risk, independent of other intervenient factors. These results suggest that elevated AOPP levels could be used to predict mortality risk in elderly patients.
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria , Brazil.
authors.forename: T O
authors.initials: TO
authors.lastname: Silva
authors.forename: I E C
authors.initials: IE
authors.lastname: Jung
authors.forename: R N
authors.initials: RN
authors.lastname: Moresco
authors.forename: F
authors.initials: F
authors.lastname: Barbisan
authors.forename: E E
authors.initials: EE
authors.lastname: Ribeiro
authors.forename: E A M
authors.initials: EA
authors.lastname: Ribeiro
authors.forename: K
authors.initials: K
authors.lastname: Motta
authors.forename: E
authors.initials: E
authors.lastname: Britto
authors.forename: E
authors.initials: E
authors.lastname: Tasch
authors.forename: G
authors.initials: G
authors.lastname: Bochi
authors.forename: M M F
authors.initials: MM
authors.lastname: Duarte
authors.forename: A R
authors.initials: AR
authors.lastname: Oliveira
authors.forename: M
authors.initials: M
authors.lastname: Marcon
authors.forename: C
authors.initials: C
authors.lastname: Belló
authors.forename: G F
authors.initials: GF
authors.lastname: dos Santos Montagner
authors.forename: I B M
authors.initials: IB
authors.lastname: da Cruz
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers; D001938:Brazil; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009026:Mortality; D018384:Oxidative Stress; D012306:Risk
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers
keywords: advanced oxidation protein products; aging; epidemiology