title: Β-catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition.
abstract: Previously, we found that brain expressed X-linked gene 2 (Bex2) regulates the invasion/migration ability of glioma cells. However, the mechanism of this effect remains unknown. In current study, we reported that Bex2 down-regulation inhibited glioma cell migration and invasion by decreasing the nucleus and cytoplasm protein level of β-catenin. We found that the protein levels of Bex2 and β-catenin were up-regulated and showed direct correlation in glioma tissues. Bex2 down-regulation significantly decreased β-catenin protein levels but not its mRNA levels. Furthermore, the decreased protein level of β-catenin was located in the nucleus and cytoplasm but not in the cell membrane. Further study found that the effects of Bex2 down-regulation on the invasion and migration of glioma cell could be reversed by β-catenin over-expression. Taken together, Bex2 affects the invasion and migration ability of glioma cells by regulating β-catenin.
authors.affiliation: The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Er
authors.initials: E
authors.lastname: Nie
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Shao
authors.initials: S
authors.lastname: Xie
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Jinxia
authors.initials: J
authors.lastname: Hu
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Qingming
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China. Electronic address: xpzhou@xzmc.edu.cn.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China. Electronic address: yu.rutong@163.com.
authors.forename: Rutong
authors.initials: R
authors.lastname: Yu
mesh_terms: D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D003593:Cytoplasm / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D014945:Wound Healing; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C530662:BEX2 protein, human; C495270:CTNNB1 protein, human; D009419:Nerve Tissue Proteins; D034741:RNA, Small Interfering; D051176:beta Catenin
keywords: Bex2; Glioblastoma; Invasion; Migration; β-Catenin