title: Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To analyze whether leukocyte telomere length (LTL) is impaired in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  A total of 274 women, including 150 patients with PCOS and 124 controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Body mass index (BMI), waist circumference, systemic arterial pressure, lipid profile, E(2), LH, T, androstenedione, PRL, TSH, sex hormone-binding globulin, C-reactive protein (CRP), homocysteine, free androgen index, and the homeostatic model of insulin sensitivity (HOMA-IR) index were analyzed. The LTL evaluation was measured by quantitative polymerase chain reaction.
  
  
  RESULTS
  The PCOS group had higher values for weight, BMI, waist circumference, systolic arterial pressure, triglycerides, LH, T, insulin, CRP, free androgen index, and HOMA-IR compared with the control group. Sex hormone-binding globulin and E(2) levels were lower in the PCOS group than in the control group. The LTL did not differ between groups. Age, BMI, and HOMA-IR had no significant effect on LTL. The inflammatory biomarkers CRP and homocysteine were negatively correlated with LTL in patients with PCOS.
  
  
  CONCLUSIONS
  Our results showed no differences in LTL between patients with PCOS and controls, but CRP and homocysteine biomarkers negatively correlated with LTL in the PCOS group.
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Daiana Cristina Chielli
authors.initials: DC
authors.lastname: Pedroso
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Cristiana Libardi
authors.initials: CL
authors.lastname: Miranda-Furtado
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Gislaine Satyko
authors.initials: GS
authors.lastname: Kogure
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Meola
authors.affiliation: Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida.
authors.forename: Maja
authors.initials: M
authors.lastname: Okuka
authors.affiliation: Center for Reproductive Medicine, Orlando, Florida.
authors.forename: Celso
authors.initials: C
authors.lastname: Silva
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Rodrigo T
authors.initials: RT
authors.lastname: Calado
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Rui Alberto
authors.initials: RA
authors.lastname: Ferriani
authors.affiliation: Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, New York.
authors.forename: David L
authors.initials: DL
authors.lastname: Keefe
authors.affiliation: Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. Electronic address: romareis@fmrp.usp.br.
authors.forename: Rosana Maria
authors.initials: RM
authors.lastname: dos Reis
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis*; D016615:Telomere / Q000378:metabolism*; D059505:Telomere Homeostasis / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: Polycystic ovary syndrome; hyperandrogenism; inflammatory biomarkers; oxidative stress; telomeres