title: Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.
abstract: In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to address, especially for those from less understood putative new cancer genes. As a powerful approach, in silico bioinformatics analysis could efficiently sort out mutations that are predicted to damage gene function. Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1//2 as negative growth regulators and tumor suppressors.
authors.affiliation: Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Yu
authors.forename: John
authors.initials: J
authors.lastname: Bachman
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Lai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D018797:Cell Cycle Proteins; D019295:Computational Biology; D052138:Genes, Neoplasm; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D000090742:Serine-Threonine Kinase 3; D017855:Transferases (Other Substituted Phosphate Groups) / Q000737:chemistry / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000091102:YAP-Signaling Proteins; D000099317:Hippo Kinases
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases; D000090742:Serine-Threonine Kinase 3; D017855:Transferases (Other Substituted Phosphate Groups); D025521:Tumor Suppressor Proteins; D000091102:YAP-Signaling Proteins; C539495:Wwc1 protein, mouse; C486223:Yap1 protein, mouse; C485607:ajuba protein, mouse; C092745:LATS1 protein, human; C490660:Stk4 protein, mouse; D000099317:Hippo Kinases; C406449:LATS2 protein, human; C490818:Stk3 protein, mouse; C556686:Sgms1 protein, mouse