title: Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.
abstract: BACKGROUND
  The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.
  
  
  METHODS
  Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.
  
  
  RESULTS
  Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.
  
  
  CONCLUSIONS
  Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Gloria
authors.initials: G
authors.lastname: Pelizzo
authors.affiliation: b Department of Medical and Biological Sciences , University of Udine , Udine , Italy .
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Mimmi
authors.affiliation: b Department of Medical and Biological Sciences , University of Udine , Udine , Italy .
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ballico
authors.affiliation: c Cincinnati Fetal Center, Pediatric Surgery Division, CCHMC , Cincinnati , OH , USA .|d Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d'Hebron , Edifici Infantil , Barcelona , Spain .
authors.forename: Mario
authors.initials: M
authors.lastname: Marotta
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Ilaria
authors.initials: I
authors.lastname: Goruppi
authors.affiliation: c Cincinnati Fetal Center, Pediatric Surgery Division, CCHMC , Cincinnati , OH , USA .|d Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d'Hebron , Edifici Infantil , Barcelona , Spain .
authors.forename: Jose Louis
authors.initials: JL
authors.lastname: Peiro
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Elisa
authors.initials: E
authors.lastname: Zambaiti
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Federico
authors.initials: F
authors.lastname: Costanzo
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Erika
authors.initials: E
authors.lastname: Andreatta
authors.affiliation: a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
authors.forename: Elena
authors.initials: E
authors.lastname: Tonin
authors.affiliation: e Department of the Mother and Child Health, Pediatric Unit , IRCCS Policlinico San Matteo Foundation Pavia , Pavia , Italy , and.|f Department of Internal Medicine University of Pavia , Pavia , Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Calcaterra
mesh_terms: D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000378:metabolism*; D008297:Male; D055442:Metabolome; D010641:Phenotype; D015619:Respiratory System Abnormalities / Q000378:metabolism*
keywords: Congenital lung malformations; metabolomic; translational research