title: Systemic oxidative stress biomarkers in chronic periodontitis: a meta-analysis.
abstract: Oxidative stress biomarkers have been observed in peripheral blood of chronic periodontitis patients; however, their associations with periodontitis were not consistent. This meta-analysis was performed to clarify the associations between chronic periodontitis and oxidative biomarkers in systemic circulation. Electronic searches of PubMed and Embase databases were performed until October 2014 and articles were selected to meet inclusion criteria. Data of oxidative biomarkers levels in peripheral blood of periodontitis patients and periodontal healthy controls were extracted to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) by using random-effects model. Of 31 eligible articles, 16 articles with available data were included in meta-analysis. Our results showed that periodontitis patients had significantly lower levels of total antioxidant capacity (SMD = -2.02; 95% CI: -3.08, -0.96; P = 0.000) and higher levels of malondialdehyde (SMD = 0.99; 95% CI: 0.12, 1.86; P = 0.026) and nitric oxide (SMD = 4.98; 95% CI: 2.33, 7.63; P = 0.000) than periodontal healthy control. Superoxide dismutase levels between two groups were not significantly different (SMD = -1.72; 95% CI: -3.50, 0.07; P = 0.059). In conclusion, our meta-analysis showed that chronic periodontitis is significantly associated with circulating levels of three oxidative stress biomarkers, indicating a role of chronic periodontitis in systemic diseases.
authors.affiliation: Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China ; Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China ; Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Song
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Laboratory of Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China ; Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.
authors.forename: Zuomin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood*; D006801:Humans; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers