title: Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse.
abstract: Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying mechanisms and crosstalk with other oncogenic factors, we developed the NRL-PRL mouse. In this model, mammary expression of a rat prolactin transgene raises local exposure to PRL without altering estrous cycling. Nulliparous females develop metastatic, histotypically diverse mammary carcinomas independent from ovarian steroids, and most are ER+. These characteristics resemble the human clinical disease, facilitating study of tumorigenesis, and identification of novel preventive and therapeutic approaches.
authors.affiliation: Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA, olearyk@svm.vetmed.wisc.edu.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: O'Leary
authors.forename: Michael P
authors.initials: MP
authors.lastname: Shea
authors.forename: Linda A
authors.initials: LA
authors.lastname: Schuler
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D011388:Prolactin / Q000097:blood / Q000235:genetics / Q000502:physiology*; D051381:Rats; D020239:Receptor Cross-Talk / Q000502:physiology
chemical_list: D047628:Estrogen Receptor alpha; D004958:Estradiol; D011388:Prolactin