title: Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy.
abstract: Cell behaviors, including proliferation, differentiation and apoptosis, are intricately controlled during organ development and tissue regeneration. In the past 9 years, the Hippo signaling pathway has been delineated to play critical roles in organ size control, tissue regeneration and tumorigenesis through regulating cell behaviors. In mammals, the core modules of the Hippo signaling pathway include the MST1/2-LATS1/2 kinase cascade and the transcriptional co-activators YAP/TAZ. The activity of YAP/TAZ is suppressed by cytoplasmic retention due to phosphorylation in the canonical MST1/2-LATS1/2 kinase cascade-dependent manner or the non-canonical MST1/2- and/or LATS1/2-independent manner. Hippo signaling pathway, which can be activated or inactivated by cell polarity, contact inhibition, mechanical stretch and extracellular factors, has been demonstrated to be involved in development and tumorigenesis of liver and pancreas. In addition, we have summarized several small molecules currently available that can target Hippo-YAP pathway for potential treatment of hepatic and pancreatic cancers, providing clues for other YAP initiated cancers therapy as well.
authors.affiliation: College of life science, Northeast Forestry University , Harbin , China.
authors.forename: Delin
authors.initials: D
authors.lastname: Kong
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tong
authors.initials: T
authors.lastname: Men
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Teng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016764:Cell Polarity / Q000187:drug effects; D000090683:Hippo Signaling Pathway; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries; D017346:Protein Serine-Threonine Kinases
keywords: Cancer gene therapy; hepatic targeting; in vitro model; tumor targeting