title: Modulation of physical activity to optimize pain sensation following an intra-articular corticosteroid injection in patients with knee osteoarthritis.
abstract: BACKGROUND
  Intra-articular corticosteroid injection is often used to relieve pain caused by knee osteoarthritis. This study aims to assess the impact after an intra-articular corticosteroid injection treatment on objective and subjective measurement of physical function in knee osteoarthritis patients.
  
  
  METHODS
  Fourteen patients with unilateral knee osteoarthritis participated in this open-label uncontrolled trial. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. Symptoms, quality of life and spatiotemporal parameters of gait were assessed every two weeks.
  
  
  RESULTS
  From the injection until six weeks later, pain and stiffness were reduced by approximately 60%. Patients' daily physical activity time was significantly improved after injection: participation in light and moderate physical activities increased during four and two weeks, respectively.
  
  
  CONCLUSIONS
  The beneficial effects after the intra-articular corticosteroid injection are visible in the duration and intensity of the knee osteoarthritis patients' daily physical activity. However, these effects declined gradually two weeks after injection. Modulating the intensity and duration of physical activity would allow patients to optimize pain sensation over a longer period following an intra-articular corticosteroid injection. Trial Registration. This trial was registered with ClinicalTrials: NCT02049879.
authors.affiliation: Département de Kinésiologie, Faculté de Médecine, Université Laval, 2300 rue de la Terrasse, Quebec City, QC, Canada G1V 0A6 ; Unité de Recherche sur le Vieillissement, Centre de Recherche FRSQ du CHA Universitaire de Québec, 1050 Chemin Sainte-Foy, Quebec City, QC, Canada G1S 4L8.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Dessery
authors.affiliation: Division de Chirurgie Orthopédique, CHUQ, 11 Côte du Palais, Quebec City, QC, Canada G1R 2J6 ; Département de Chirurgie, Faculté de Médecine, Université Laval, 1050 avenue de la Médecine, Quebec City, QC, Canada G1V 0A6.
authors.forename: Étienne L
authors.initials: ÉL
authors.lastname: Belzile
authors.affiliation: Division de Chirurgie Orthopédique, CHUQ, 11 Côte du Palais, Quebec City, QC, Canada G1R 2J6.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Turmel
authors.affiliation: Département de Kinésiologie, Faculté de Médecine, Université Laval, 2300 rue de la Terrasse, Quebec City, QC, Canada G1V 0A6.
authors.forename: Jean
authors.initials: J
authors.lastname: Doré
authors.affiliation: Département de Kinésiologie, Faculté de Médecine, Université Laval, 2300 rue de la Terrasse, Quebec City, QC, Canada G1V 0A6 ; Unité de Recherche sur le Vieillissement, Centre de Recherche FRSQ du CHA Universitaire de Québec, 1050 Chemin Sainte-Foy, Quebec City, QC, Canada G1S 4L8.
authors.forename: Binta
authors.initials: B
authors.lastname: Diallo
authors.affiliation: Département de Kinésiologie, Faculté de Médecine, Université Laval, 2300 rue de la Terrasse, Quebec City, QC, Canada G1V 0A6 ; Unité de Recherche sur le Vieillissement, Centre de Recherche FRSQ du CHA Universitaire de Québec, 1050 Chemin Sainte-Foy, Quebec City, QC, Canada G1S 4L8.
authors.forename: Philippe
authors.identifier: 0000-0002-9934-3825
authors.initials: P
authors.lastname: Corbeil
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones