title: Comparison of Serum Lipid Profile in HIV Positive Patients on ART with ART Naïve Patients.
abstract: BACKGROUND
  The widespread use of effective highly active antiretroviral therapy (HAART) in HIV patients has coincided with increasing reports of complications like HIV-associated lipodystrophy syndrome and the metabolic alterations, affecting the lipid and glucose metabolism. Evidences in support of lipodystrophy and dyslipidaemia associated with First- line HAART in our area is scarce. The aim of the present study was 1) to study and compare Lipid profile in HIV positive patients on ART with that of freshly diagnosed HIV positive patients who were yet to be started on ART. 2) To assess lipodystrophy syndrome in patients on ART.
  
  
  METHODS
  Hundred newly diagnosed HIV positive patients who were yet to be started on ART were taken as controls (ART-Naïve).Hundred randomly selected HIV+ patients who were already on First-line ART regimen (Stavudine/Zudovudine + Lamivudine + Nevirapine) for more than 12 months were taken as cases (ART). This study was conducted for a period of 12 months at the VIMS ART centre, Bellary, Karnataka, India.
  
  
  RESULTS
  There was a significant increase (p<0.001) in serum Total Cholesterol, LDL-C, TG, VLDL, Non-HDL -C & TC/HDL-C ratio in ART patients compared to ART-naïve patients. Of the 100 ART patients 23 had lipodystrophy syndrome (buffalo hump, abnormal fat deposition around neck & back, buccal fat resorption, increase in abdominal fat).
  
  
  CONCLUSIONS
  To conclude, it is evident from our study that there is increase in lipid profile (except HDL) in ART patients compared to ART Naïve group and 23 ART patients showed lipodystrophy syndrome. Hence it appears reasonable to measure fasting lipid levels before and 3-6 months after antiretroviral therapy is initiated or when ART regimen is changed.
authors.affiliation: Professor & HOD, Department of Biochemistry, Vijaynagar Institute of Medical sciences , Bellary, Karnataka, India .
authors.forename: Indumati
authors.initials: I
authors.lastname: V
authors.affiliation: Associate Professor, Department of Biochemistry, Vijaynagar Institute of Medical sciences , Bellary, Karnataka, India .
authors.forename: Vijay
authors.initials: V
authors.lastname: V
authors.affiliation: Associate Professor, Department of Biochemistry, Vijaynagar Institute of Medical sciences , Bellary, Karnataka, India .
authors.forename: M S
authors.initials: MS
authors.lastname: Shekhanawar
authors.affiliation: Associate Professor, Department of Biochemistry, Vijaynagar Institute of Medical sciences , Bellary, Karnataka, India .
authors.lastname: Rajeshwari
authors.affiliation: Associate Professor, Department of Biochemistry, Vijaynagar Institute of Medical sciencesRamaiah , Bellary, Karnataka, India .
authors.forename: Amareshwaras
authors.initials: A
authors.lastname: M
authors.affiliation: PG cum Tutor, Department of Biochemistry, Vijaynagar Institute of Medical sciences , Bellary, Karnataka, India .
authors.forename: Shantala
authors.initials: S
authors.lastname: D
keywords: First line HAART regimen; Lipid profile; Lipodystrophy syndrome