title: Epigenetics, embryo quality and developmental potential.
abstract: It is very important for embryologists to understand how parental inherited genomes are reprogrammed after fertilisation in order to obtain good-quality embryos that will sustain further development. In mammals, it is now well established that important epigenetic modifications occur after fertilisation. Although gametes carry special epigenetic signatures, they should attain embryo-specific signatures, some of which are crucial for the production of healthy embryos. Indeed, it appears that proper establishment of different epigenetic modifications and subsequent scaffolding of the chromatin are crucial steps during the first cleavages. This 'reprogramming' is promoted by the intimate contact between the parental inherited genomes and the oocyte cytoplasm after fusion of the gametes. This review introduces two main epigenetic players, namely histone post-translational modifications and DNA methylation, and highlights their importance during early embryonic development.
authors.affiliation: INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France. Email:
authors.forename: Nathalie
authors.initials: N
authors.lastname: Beaujean
mesh_terms: D000818:Animals; D001947:Breeding / Q000379:methods; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D008954:Models, Biological; D053652:Nuclear Transfer Techniques; D011499:Protein Processing, Post-Translational / Q000502:physiology*
chemical_list: D006657:Histones