title: Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling.
abstract: We used pharmacological modulation of the mGlu5 receptor to investigate its role in the extinction of conditioned fear throughout development. In postnatal day (P) 17 rats, the positive allosteric modulator CDPPB facilitated, while the negative allosteric modulator MTEP impaired extinction. These drugs had no such effects on P24 or adult rats. These results establish a changing importance of mGlu5 in extinction of conditioned fear at distinct stages of development.
authors.affiliation: Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: despina.ganella@florey.edu.au.
authors.forename: Despina E
authors.initials: DE
authors.lastname: Ganella
authors.affiliation: Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
authors.forename: Pushbalela
authors.initials: P
authors.lastname: Thangaraju
authors.affiliation: Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lawrence
authors.affiliation: Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: drjeehyunkim@gmail.com.
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000494:Allosteric Regulation; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D004597:Electroshock; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects / Q000502:physiology; D008297:Male; D009483:Neuropsychological Tests; D011720:Pyrazoles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D064529:Receptor, Metabotropic Glutamate 5 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology
chemical_list: C472365:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine; C494553:3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide; D001549:Benzamides; D018683:Excitatory Amino Acid Agents; C578937:Grm5 protein, rat; D011720:Pyrazoles; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D013844:Thiazoles
keywords: CDPPB; Development; Extinction; Fear; MTEP; Mglu5