title: Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance.
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam.
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: Ariës
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam.
authors.forename: Rosanna E
authors.initials: RE
authors.lastname: van den Dungen
authors.affiliation: Department of Medical Genetics, University Medical Center Utrecht Center for Personalized Cancer Treatment.
authors.forename: Marco J
authors.initials: MJ
authors.lastname: Koudijs
authors.affiliation: Department of Medical Genetics, University Medical Center Utrecht Center for Personalized Cancer Treatment.
authors.forename: Edwin
authors.initials: E
authors.lastname: Cuppen
authors.affiliation: Department of Medical Genetics, University Medical Center Utrecht Center for Personalized Cancer Treatment.
authors.forename: Emile
authors.initials: E
authors.lastname: Voest
authors.affiliation: Department of Human Genetics, Academic Medical Centre, University of Amsterdam Individualized Therapies for Children with Cancer Study Group.
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Molenaar
authors.affiliation: Department of Human Genetics, Academic Medical Centre, University of Amsterdam Individualized Therapies for Children with Cancer Study Group.
authors.forename: Huib N
authors.initials: HN
authors.lastname: Caron
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam Individualized Therapies for Children with Cancer Study Group Dutch Childhood Oncology Group, The Hague, The Netherlands.
authors.forename: Rob
authors.initials: R
authors.lastname: Pieters
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam Individualized Therapies for Children with Cancer Study Group Dutch Childhood Oncology Group, The Hague, The Netherlands m.l.denboer@erasmusmc.nl.
authors.forename: Monique L
authors.initials: ML
authors.lastname: den Boer
mesh_terms: D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D019008:Drug Resistance, Neoplasm; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D057285:Precision Medicine; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011239:Prednisolone
keywords: RAS; clonal mutations; pediatric acute lymphoblastic leukemia; prednisolone resistance