title: Clinical usefulness of oral immunoglobulins in lung transplant recipients with norovirus gastroenteritis: a case series.
abstract: Viral gastroenteritis causing diarrhea is a common complication observed in lung transplant recipients. Differently from the mild and typically self-limited disease seen in immunocompetent subjects, immunocompromised patients frequently have a more severe course. Norovirus and rotavirus are among the leading causes of severe gastroenteritis in transplant recipients. Specific treatment is unavailable, although good supportive treatment can significantly reduce morbidity. Previous studies have suggested that oral immunoglobulins may be used for the treatment of acute viral gastroenteritis after solid-organ transplantation. Herein, we conducted a retrospective chart review of 12 lung transplant recipients with norovirus-induced gastroenteritis who were treated with oral immunoglobulins for 2 days. Eleven patients were successfully treated, whereas 1 subject was only mildly improved. Four patients had at least 1 recurrence. No significant adverse effects were observed. We conclude that oral immunoglobulins may be clinically useful for lung transplant recipients with norovirus-induced gastroenteritis.
authors.affiliation: Department of Pharmacy, Strasbourg University Hospital, Strasbourg, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Gairard-Dory
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: T
authors.initials: T
authors.lastname: Dégot
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Hirschi
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Schuller
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Leclercq
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France.
authors.forename: B
authors.initials: B
authors.lastname: Renaud-Picard
authors.affiliation: Department of Pharmacy, Strasbourg University Hospital, Strasbourg, France.
authors.forename: B
authors.initials: B
authors.lastname: Gourieux
authors.affiliation: Department of Pneumology, Strasbourg University Hospital, Strasbourg, France. Electronic address: romain.kessler@chru-strasbourg.fr.
authors.forename: R
authors.initials: R
authors.lastname: Kessler
mesh_terms: D000284:Administration, Oral; D017250:Caliciviridae Infections / Q000188:drug therapy* / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007136:Immunoglobulins / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D029322:Norovirus; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D012189:Retrospective Studies; D066027:Transplant Recipients
chemical_list: D007136:Immunoglobulins; D007155:Immunologic Factors