title: Elements toward novel therapeutic targeting of the adrenergic system.
abstract: Adrenergic receptors belong to the family of the G protein coupled receptors that represent important targets in the modern pharmacotherapies. Studies on different physiological and pathophysiological properties of the adrenergic system have led to novel evidences and theories that suggest novel possible targeting of such system in a variety of pathologies and disorders, even beyond the classical known therapeutic possibilities. Herein, those advances have been illustrated with selected concepts and different examples. Furthermore, we illustrated the applications and the therapeutic implications that such findings and advances might have in the contexts of experimental pharmacology, therapeutics and clinic. We hope that the content of this work will guide researches devoted to the adrenergic aspects that combine neurosciences with pharmacology.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China; University of Chinese Academy of Science, Beijing, China. Electronic address: ghanemiabdelaziz@hotmail.com.
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Ghanemi
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China; Key State Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China. Electronic address: xthu@mail.kiz.ac.cn.
authors.forename: Xintian
authors.initials: X
authors.lastname: Hu
mesh_terms: D018663:Adrenergic Agents / Q000627:therapeutic use; D002490:Central Nervous System / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D011941:Receptors, Adrenergic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018663:Adrenergic Agents; D011941:Receptors, Adrenergic
keywords: Adrenergic system; GPCR; Pharmacological target; Therapeutic potential