title: Role of Methadone in Induction and/or Exacerbation of Cluster Headache in Patients Treated for Opioid Addiction.
abstract: Methadone is a potent opioid agonist widely used in opioid maintenance therapy. In some countries, methadone is available for pain treatment. We report the cases of two patients with history of substance abuse (mainly heroin), who presented with cluster headache possibly related to high-dose methadone. One possible explanation for the severe pain described in these cases is hyperalgesia induced by high doses of methadone.
authors.affiliation: Département de pharmacologie médicale et toxicologie, Centre d'addictovigilance, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Diot
authors.affiliation: Département de pharmacologie médicale et toxicologie, Centre d'addictovigilance, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Eiden
authors.affiliation: Unité de traitement des toxicodépendances, Médecine interne E - addictologie, Hôpital Saint Eloi, CHU Montpellier, Montpellier, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Leglise
authors.affiliation: Département de médecine interne et addictologie, Hôpital Saint-Eloi, CHU Montpellier, Montpellier, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Donnadieu-Rigole
authors.affiliation: Département de pharmacologie médicale et toxicologie, Centre d'addictovigilance, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Peyrière
mesh_terms: D000328:Adult; D003027:Cluster Headache / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D006556:Heroin Dependence / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000009:adverse effects*; D058850:Opiate Substitution Treatment / Q000009:adverse effects / Q000379:methods
chemical_list: D008691:Methadone