title: Larvicidal activity of the methanol extract and fractions of the green fruits of Solanum lycocarpum (Solanaceae) against the vector Culex quinquefasciatus (Diptera: Culicidae).
abstract: BACKGROUND
  The larvicidal activity of Solanum lycocarpum against Culex quinquefasciatus is unknown.
  
  
  METHODS
  We evaluated the larvicidal activity of extracts of the green fruits of Solanum lycocarpum against third and fourth instar larvae of C. quinquefasciatus.
  
  
  RESULTS
  Dichloromethane and ethyl acetate fractions showed the greatest larvicidal effect at 200mg/L (83.3% and 86.7%, respectively). The methanol and dichloromethane, ethyl acetate, and hydromethanolic fractions demonstrated larvicidal effects against C. quinquefasciatus, with LC50 values of 126.24, 75.13, 83.15, and 207.05 mg/L, respectively.
  
  
  CONCLUSIONS
  Thus, when considering new drugs with larvicidal activity from natural products, S. lycocarpum fruits may be good candidate sources.
authors.affiliation: Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
authors.forename: Thamer Matias
authors.initials: TM
authors.lastname: Pereira
authors.affiliation: Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
authors.forename: Viviane de Cássia Bicalho
authors.initials: Vde C
authors.lastname: Silva
authors.affiliation: Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
authors.forename: José Antônio
authors.initials: JA
authors.lastname: Ribeiro Neto
authors.affiliation: Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
authors.forename: Stênio Nunes
authors.initials: SN
authors.lastname: Alves
authors.affiliation: Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
authors.forename: Luciana Alves Rodrigues dos Santos
authors.initials: LA
authors.lastname: Lima
mesh_terms: D000818:Animals; D001681:Biological Assay; D003465:Culex / Q000187:drug effects*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D010936:Plant Extracts / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*
chemical_list: D010936:Plant Extracts