title: Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis.
abstract: BACKGROUND
  Paraoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment.
  
  
  METHODS
  A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated.
  
  
  RESULTS
  In the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively).
  
  
  CONCLUSIONS
  Low serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.
authors.affiliation: Department of Neonatology, Faculty of Medicine, Selcuk University, Konya, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Annagür
authors.affiliation: Department of Neonatology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Örs
authors.affiliation: Department of Neonatology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Altunhan
authors.affiliation: Department of Clinical Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.affiliation: Department of Neonatology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Ertuğrul
authors.affiliation: Department of Neonatology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Konak
authors.affiliation: Department of Neonatology, Faculty of Medicine, Selcuk University, Konya, Turkey.
authors.forename: Saime Sündüz
authors.initials: SS
authors.lastname: Uygun
authors.affiliation: Department of Neonatology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Pekcan
authors.affiliation: Department of Clinical Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Erbay
authors.affiliation: Department of Clinical Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
authors.forename: İdris
authors.initials: İ
authors.lastname: Mehmetoğlu
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D000071074:Neonatal Sepsis / Q000097:blood*; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D012189:Retrospective Studies
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D043303:Aryldialkylphosphatase
keywords: neonatal sepsis; oxidative stress index; paraoxonase-1; total antioxidant state; total oxidant state