title: Evidence for a 12 kDa "Carrier Protein" for Natriuretic Hormone.
abstract: The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 Da. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF.
authors.affiliation: Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, CA , USA.
authors.forename: Harvey C
authors.initials: HC
authors.lastname: Gonick
keywords: Anf; carrier proteins; hormones; hypertension; natriuretic hormone; proANF; review