title: Current concepts in C3 glomerulopathy.
abstract: Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis. The key histological feature is the presence of isolated C3 deposits without immunoglobulins. Often masqueradng as some of the common glomerulonephritides this is a prototype disorder occurring from dysregulated alternate complement pathway with recently identified genetic defects and autoantibodies. We review the pathophysiology, clinical features, and diagnostic and treatment strategies.
authors.affiliation: Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Thomas
authors.affiliation: Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Ranganathan
authors.affiliation: Department of Pathology, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Francis
authors.affiliation: Department of Renal Medicine, Hervey Bay Hospital, Hervey Bay, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Madhan
authors.affiliation: Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: G T
authors.initials: GT
authors.lastname: John
keywords: Alternate complement pathway; complement component 3 glomerulonephritis; complement component 3 glomerulopathy; complements; dense deposit disease