title: The direct asymmetric alkylation of α-amino aldehydes with 3-indolylmethanols by enamine catalysis.
abstract: This work describes an efficient α-alkylation reaction of α-amino aldehydes with 3-indolylmethanols. In the promotion of catalyst 3f, the target products were obtained in high yields (up to 99%), good diastereoselectivities (up to 88:12), and excellent enantioselectivities (up to 96% ee). The direct alkylation products can be readily converted into other tryptophan derivatives without the loss of stereoselectivities.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing 400715, China.
authors.forename: Zhi-Lei
authors.initials: ZL
authors.lastname: Guo
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Xue
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Fu
authors.forename: Shun-En
authors.initials: SE
authors.lastname: Zhang
authors.forename: Qi-Xiang
authors.initials: QX
authors.lastname: Guo