title: The TNFAIP3 polymorphism rs610604 both associates with the risk of psoriasis vulgaris and affects the clinical severity.
abstract: BACKGROUND
  Genome-wide association studies in white and Chinese Han populations have found that the single-nucleotide polymorphism (SNP) rs610604, at the tumour necrosis factor (TNF)-α-induced protein 3 (TNFAIP3) locus, is associated with psoriasis, and is also associated with response to TNF blockade in psoriasis.
  
  
  OBJECTIVE
  To examine whether this SNP is also associated with the clinical traits of psoriasis vulgaris (PV).
  
  
  METHODS
  A hospital-based case-control study was performed, which involved 647 subjects [351 patients with PV and 296 healthy controls (HC)]. The rs610604 variants were typed using a SNaPshot assay.
  
  
  RESULTS
  Both the G allele and the dominant model genotype (GG + GT) of rs610604 were associated with risk of PV (OR = 1.53; P = 0.01 and OR = 1.68, P < 0.01, respectively). In genotype-phenotype analysis, both the G allele and the GG + GT genotype were also associated with the clinical severity of PV. Severe cases [Psoriasis Area and Severity Index (PASI) > 6] had a higher frequency of the G allele and the GG + GT genotype compared with mild cases (PASI ≤ 6) (OR = 2.03, P = 0.001 and OR = 2.46, P < 0.001, respectively). In addition, rs610604 was significantly associated with almost all of the phenotypes in subphenotype-control analyses.
  
  
  CONCLUSIONS
  SNP rs610604 in the TNFAIP3 locus is associated with the clinical severity of PV in a Chinese Han population.
authors.affiliation: Department of Dermatology, Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: K-J
authors.initials: KJ
authors.lastname: Zhu
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: C
authors.initials: C
authors.lastname: Quan
authors.affiliation: Department of Dermatology, Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Department of Dermatology, Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Zhu
authors.affiliation: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: K-S
authors.initials: KS
authors.lastname: Li
authors.affiliation: Department of Dermatology, Anhui Provincial Hospital, Hefei, Anhui, China.
authors.forename: Y-M
authors.initials: YM
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology; D012720:Severity of Illness Index; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3