title: Increase in perioperative complications following primary total hip and knee arthroplasty in patients with hepatitis C without cirrhosis.
abstract: The effects of hepatitis C on primary total hip (THA) and knee (TKA) arthroplasties are poorly understood. The National Hospital Discharge Survey was used to identify patients who underwent THA or TKA between 1990 and 2007 without a diagnosis of cirrhosis, HIV, or hepatitis A, B, D or E virus infection. Patients were split into two groups: 1) hepatitis C (n=26,444) and 2) non-hepatitis C (n=8,336,882) and analyzed for differences in length of hospital stay, discharge status and perioperative complications. Those with hepatitis C had shorter hospital stays, higher rates of nonroutine discharge and higher odds of in-hospital complications (OR: 1.686, range: 1.645-1.727), surgery related complications (OR: 1.559, range: 1.516-1.603) and general medical complications (OR: 2.012, range: 1.961-2.064) (P<0.001).
authors.affiliation: University of Miami Miller School of Medicine, Department of Orthopaedic Surgery and Rehabilitation, Miami, Florida.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Best
authors.affiliation: University of Miami Miller School of Medicine, Department of Orthopaedic Surgery and Rehabilitation, Miami, Florida.
authors.forename: Leonard T
authors.initials: LT
authors.lastname: Buller
authors.affiliation: Cleveland Clinic Department of Orthopaedic Surgery, Cleveland, Ohio.
authors.forename: Alison K
authors.initials: AK
authors.lastname: Klika
authors.affiliation: Cleveland Clinic Department of Orthopaedic Surgery, Cleveland, Ohio.
authors.forename: Wael K
authors.initials: WK
authors.lastname: Barsoum
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000150:complications / Q000601:surgery*; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology
keywords: hepatitis C; total hip arthroplasty; total joint arthroplasty; total knee arthroplasty; transfusion