title: Glucose and Fatty Acid Metabolism in Placental Explants From Pregnancies Complicated With Gestational Diabetes Mellitus.
abstract: Placental metabolism is an important mechanism for the regulation of fetal growth and long-term health of the newborns. In this study, we investigated the effects of maternal metabolic environment on human placental fatty acid and glucose metabolism. We used placental explants from uncomplicated pregnancies or pregnancies complicated with gestational diabetes mellitus (GDM), undergoing vaginal delivery (VD) or cesarean section (CS). Fatty acid oxidation (FAO) and glucose uptake (2-DOG) were similar in both modes of delivery in normal and GDM pregnancies. However, placental explants from GDM exhibited 40% to 50% reduced FAO capacity compared to control placentas in women undergoing VD or CS. In contrast, 2-DOG uptake was 2- to 3-fold higher in placental explants from GDM compared to control placentas in women undergoing VD or CS, respectively. In conclusion, ex vivo placental fuel selection is influenced by maternal GDM, but placental metabolic characteristics are not altered by the mode of delivery.
authors.affiliation: Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Visiedo
authors.affiliation: Department of Obstetrics and Gynecology, Puerta del Mar University Hospital, Cádiz, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Bugatto
authors.affiliation: Division of Maternal-Fetal Medicine, Ginemed, Sevilla, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: Quintero-Prado
authors.affiliation: Research Unit, Puerta del Mar University Hospital, Cádiz, Spain Instituto de Genética y Biología Molecular (IBGM)-Universidad de Valladolid, Valladolid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Cózar-Castellano
authors.affiliation: Department of Obstetrics and Gynecology, Puerta del Mar University Hospital, Cádiz, Spain Department of Obstetrics and Gynecology, La Paz University Hospital, Madrid, Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Bartha
authors.affiliation: Research Unit, Puerta del Mar University Hospital, Cádiz, Spain University of Castilla-La Mancha, School of Environmental Sciences and Biochemistry, Toledo, Spain perdomogm@yahoo.com.
authors.forename: Germán
authors.initials: G
authors.lastname: Perdomo
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D009924:Organ Culture Techniques; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D005227:Fatty Acids; D005947:Glucose
keywords: fatty acid oxidation; gestational diabetes mellitus; glucose uptake; placental villous explants