title: The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment.
abstract: Maintenance of haematopoietic stem cells and differentiation of committed progenitors occurs in highly specialized niches. The interactions of haematopoietic stem and progenitor cells (HSPCs) with cells, growth factors and extracellular matrix (ECM) components of the bone marrow (BM) microenvironment control homeostasis of HSPCs. We only start to understand the complexity of the haematopoietic niche(s) that comprises endosteal, arterial, sinusoidal, mesenchymal and neuronal components. These distinct niches produce a broad range of soluble factors and adhesion molecules that modulate HSPC fate during normal hematopoiesis and BM regeneration. Adhesive interactions between HSPCs and the microenvironment will influence their localization and differentiation potential. In this review we highlight the current understanding of the functional role of ECM- and adhesion (regulating) molecules in the haematopoietic niche during homeostatic and regenerative hematopoiesis. This knowledge may lead to the improvement of current cellular therapies and more efficient development of future cellular products.
authors.affiliation: a Department of Hematopoiesis; Sanquin Research; Landsteiner Laboratory; Academic Medical Centre ; University of Amsterdam ; Amsterdam , The Netherlands.
authors.forename: Sofieke
authors.initials: S
authors.lastname: Klamer
authors.forename: Carlijn
authors.initials: C
authors.lastname: Voermans
mesh_terms: D001853:Bone Marrow / Q000502:physiology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002454:Cell Differentiation; D005109:Extracellular Matrix / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D012038:Regeneration; D055153:Stem Cell Niche / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules
keywords: BIGH3; adhesion molecules; bone marrow niche; bone marrow regeneration; differentiation; extracellular matrix; haematopoietic stem cells; integrins; matrix proteins; periostin