title: Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: a Rochester Epidemiology Project population-based study in Minnesota.
abstract: BACKGROUND
  Cutaneous malignancy is associated with worse outcomes in patients with chronic lymphocytic leukemia (CLL).
  
  
  OBJECTIVE
  We sought to identify the incidence and recurrence rate of nonmelanoma skin cancer (NMSC) in patients with non-Hodgkin lymphoma (NHL).
  
  
  METHODS
  NMSC incidence was calculated and Cox proportional hazards models were used to evaluate associations with risk of recurrence for patients with NHL between 1976 and 2005 who were in the Rochester Epidemiology Project research infrastructure.
  
  
  RESULTS
  We identified 282 patients with CLL or small lymphocytic lymphoma and 435 with non-CLL NHL. The incidence of basal cell carcinoma and squamous cell carcinoma was 1829.3 (95% confidence interval [CI] 1306.7-2491.1) and 2224.9 (95% CI 1645.9-2941.6), respectively, in patients with CLL. The cumulative recurrence rate at 8 years after treatment with Mohs micrographic surgery was 8.3% (95% CI 0.0%-22.7%) for basal cell carcinoma and 13.4% (95% CI 0.0%-25.5%) for squamous cell carcinoma in patients with CLL.
  
  
  CONCLUSIONS
  This was a retrospective cohort study.
  
  
  CONCLUSIONS
  After Mohs micrographic surgery and standard excision of NMSC, patients with NHL had a skin cancer recurrence rate that was higher than expected. Careful treatment and monitoring of patients with NHL and NMSC are warranted.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address: brewer.jerry@mayo.edu.
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Brewer
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Tait D
authors.initials: TD
authors.lastname: Shanafelt
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Khezri
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Ivette M
authors.initials: IM
authors.lastname: Sosa Seda
authors.affiliation: Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Adeel S
authors.initials: AS
authors.lastname: Zubair
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Christian L
authors.initials: CL
authors.lastname: Baum
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Arpey
authors.affiliation: Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Call
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Randall K
authors.initials: RK
authors.lastname: Roenigk
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Carin Y
authors.initials: CY
authors.lastname: Smith
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Clark C
authors.initials: CC
authors.lastname: Otley
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology* / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000556:secondary; D015331:Cohort Studies; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000556:secondary; D005260:Female; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology*; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology*
keywords: Mohs micrographic surgery; chronic lymphocytic leukemia; immunosuppression; malignant melanoma