title: A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse.
abstract: A very fast-responsive fluorescent probe PZ-Py for imaging mitochondrial HClO/ClO(-), with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ-Py was successfully applied in the imaging of endogenous HClO/ClO(-) in the mitochondria of RAW 264.7 cells and living nude mouse.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China. yingui@nju.edu.cn.
authors.forename: Hongde
authors.initials: H
authors.lastname: Xiao
authors.forename: Kai
authors.initials: K
authors.lastname: Xin
authors.forename: Haifang
authors.initials: H
authors.lastname: Dou
authors.forename: Gui
authors.initials: G
authors.lastname: Yin
authors.forename: Yiwu
authors.initials: Y
authors.lastname: Quan
authors.forename: Ruiyong
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D006997:Hypochlorous Acid / Q000737:chemistry / Q000378:metabolism*; D008819:Mice, Nude; D008928:Mitochondria / Q000378:metabolism*; D010640:Phenothiazines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005456:Fluorescent Dyes; D010640:Phenothiazines; D006997:Hypochlorous Acid; C031637:phenothiazine