title: Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this systematic review was to evaluate the efficacy of anti-plaque chemical formulations for managing gingivitis, in 6-month, home-use, randomised clinical trials (RCTs).
  
  
  METHODS
  A protocol was designed, including inclusion and exclusion criteria to identify RCTs assessing gingival and/or bleeding indices. Electronic and hand-searches identified relevant papers, which were screened and evaluated for inclusion. Full-papers were retrieved and relevant information was extracted (also plaque indices), including quality and risk of bias. Mean treatment effects were calculated to obtain weighted mean differences (WMD) and 95% confidence intervals.
  
  
  RESULTS
  After the process of screening and selection, 87 articles with 133 comparisons, were included in the review. The additional effects of the tested products were statistically significant in terms of Löe & Silness gingival index (46 comparisons, WMD -0.217), modified gingival index (n = 23, -0.415), gingivitis severity index (n = 26, -14.939%) or bleeding index (n = 23, -7.626%), with significant heterogeneity. For plaque, additional effects were found for Turesky (66 studies, WMD -0.475), Silness & Löe (n = 26, -0.109), and plaque severity (n = 12, -23.4%) indices, with significant heterogeneity.
  
  
  CONCLUSIONS
  Within the limitations of the present study, formulations with specific agents for chemical plaque control provide statistically significant improvements in terms of gingival, bleeding and plaque indices.
authors.affiliation: ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Serrano
authors.forename: Marta
authors.initials: M
authors.lastname: Escribano
authors.forename: Silvia
authors.initials: S
authors.lastname: Roldán
authors.forename: Conchita
authors.initials: C
authors.lastname: Martín
authors.forename: David
authors.initials: D
authors.lastname: Herrera
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy* / Q000517:prevention & control; D003774:Dental Plaque Index; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D010512:Periodontal Index; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local
keywords: antiseptics; bleeding; gingivitis; plaque; systematic review