title: [Acute kidney injury secondary to the first intravenous administration of acyclovir].
abstract: Acute kidney injury secondary to precipitation of acyclovir crystals in the kidneys is well known and mainly observed in the setting of dehydration or pre-existing renal impairment. We describe a case of acute kidney injury secondary to intravenous administration of acyclovir in a 64-year-old female with trans-versal myelitis and no prior medical history. She developed a rapid rise in the plasma creatinine level only seven hours after the primary drug administration. Acyclovir was discontinued and a urinary flow rate was maintained at 100-200 ml/h with IV fluids. The kidney function returned to normal within five days.
authors.affiliation: Nyremedicinsk Afdeling C, Aarhus Universitetshospital, Brendstrupgaardsvej 100, 8200 Aarhus N. jesprant@rm.dk.
authors.forename: Jesper Mosgaard
authors.initials: JM
authors.lastname: Rantanen
authors.forename: Lars Høj
authors.initials: LH
authors.lastname: Markvardsen
authors.forename: Johannes
authors.initials: J
authors.lastname: Jakobsen
authors.forename: Henrik
authors.initials: H
authors.lastname: Birn
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D061605:Administration, Intravenous; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir