title: Dendritic cell vaccine treatment of advancedde novocolorectal cancer in renal transplant patients.
abstract: Objective: The clinical outcome, especial the immunologic responses to cancer and graft, of dendritic cell (DC) vaccine in the treatment of advanced de novo colorectal cancer (CRC) in renal transplant patients was investigated in this study. Materials and Methods: 7 patients were received 1 cycle tumor lysate pulsed autologous DC vaccine. The positive cell-mediated cytotoxicity responses to DC vaccine against CRC cell in two out of 7 patients were seen by delayed type hypersensitivity (DTH) test. The positive cell-mediated cytotoxicity responses to DC vaccine against normal kidney cell in all 7 patients were not seen by DTH tests and no notable change of renal function during and after vaccination. Conclusions: DC vaccine has emerged as a promising new strategy in the treatment of advanced de novo CRC in renal transplant patients and DC vaccines have become an attractive therapeutic option, developing immune responses specific against CRC cell, achieving clinical efficacy without graft failure.
authors.forename: J
authors.initials: J
authors.lastname: Ying
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: F
authors.initials: F
authors.lastname: Hao
authors.forename: X
authors.initials: X
authors.lastname: Xin
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Oncology, Tianjin Union Medicine Centre, Tianjin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Pang