title: Identifying aggressive forms of endometrioid-type endometrial cancer: new insights into molecular subtyping.
abstract: Clinical heterogeneity represents a great challenge for cancer therapeutics. Molecular classification of patients into different subtypes based on genetic or epigenetic characteristics has the potential to revolutionize the clinical care and mechanistic understanding of a wide spectrum of cancers, including endometrial carcinoma, the most common gynecological cancer affecting women.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Liu
authors.forename: Russell R
authors.initials: RR
authors.lastname: Broaddus
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis / Q000639:trends*; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness
chemical_list: D014408:Biomarkers, Tumor
keywords: CTNNB1 mutation; cancer therapeutics; endometrial carcinoma; molecular subtyping; wnt signaling pathway