title: Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia.
abstract: OBJECTIVE
  To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia.
  
  
  METHODS
  Three study groups were determined: Group 1-normal umbilical artery (UA; referent), Group 2-abnormal UA and normal CPR and Group 3-abnormal UA and an abnormal CPR. The primary outcome was the development of severe pre-eclampsia.
  
  
  RESULTS
  We included 270 women. Women in Group 3 had significantly elevated rates of severe pre-eclampsia versus those in Group 1 and Group 2, 52.5% versus 5.1% and 15.4%, respectively, (P<0.01), adjusted odds ratio 4.14 (95% confidence interval, 2.59 to 6.61). Kaplan-Meier analysis revealed earlier delivery in women with pre-eclampsia in Group 3 versus Group 1, Cox-Mantel hazard ratio 2.39 (1.17 to 4.88), log rank P=0.01.
  
  
  CONCLUSIONS
  An abnormal CPR is associated with a higher rate severe pre-eclampsia with delivery at earlier gestational ages than with a normal UA or an abnormal UA, but normal CPR.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: J
authors.initials: J
authors.lastname: Regan
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: H
authors.initials: H
authors.lastname: Masters
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Warshak
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*; D055815:Young Adult