title: The role of temperature in forming sol-gel biocomposites containing polydopamine.
abstract: To further improve the physical strength and biomedical applicability of bioceramicsbuilt on hydroxyapatite-gelatin (HAp-Gel) and siloxane sol-gel reactions, we incorporated mussel adhesive inspired polydopamine (PD) into our original composite based on HAp-Gel cross-linked with siloxane. Surprisingly, with the addition of PD, we observed that the processing conditions and temperatures play an important role in the structure and performance of these materials. A systematic study to investigate this temperature dependence behavior discloses that the rate of crosslinking of silane during the sol-gel process is significantly influenced by the temperature, whereas the polymerization of the dopamine only shows minor temperature dependence. With this discovery, we report an innovative thermal process for the design and application of these biocomposites.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
authors.forename: Jason Christopher
authors.initials: JC
authors.lastname: Dyke
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
authors.forename: Huamin
authors.initials: H
authors.lastname: Hu
authors.affiliation: North Carolina Oral Health Institute, School of Dentistry, University of North Carolina, CB #7454, Chapel Hill, NC 27599-7455, USA.
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: North Carolina Oral Health Institute, School of Dentistry, University of North Carolina, CB #7454, Chapel Hill, NC 27599-7455, USA ; Department of Orthodontics and Applied Materials Sciences Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7450, USA.
authors.forename: Ching-Chang
authors.initials: CC
authors.lastname: Ko
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA ; Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3216, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: You
keywords: Gelatin; Hydroxyapatite; Nanocompsite; Osteogenesis; Silicate