title: [Association of BRAF(V) 600E mutation with clinical pathological features in papillary thyroid carcinoma: meta-analysis].
abstract: OBJECTIVE
  To evaluate the association between BRAF(V) 600E mutation and pathological features in papillary thyroid carcinoma (PTC).
  
  
  METHODS
  The raleted studies were searched through Medline, PubMed, and Web of Science, and meta-analysis was used to calculate the OR and 95%CI of the study results.
  
  
  RESULTS
  A total of 52 studies including 12 029 PTC patients was identified. The prevalence of BRAF(V) 600E mutation in PTC was 57.85%. There was a closed association between the BRAF(V) 600E mutation and pathological features, including advanced TNM stage (OR = 1.89, 95%CI 1.58-2.27), lymph node metastasis (OR = 1.74, 95%CI 1.42-2.14), multifocality (OR = 1.25, 95%CI 1.07-1.46), and recurrence (OR = 2.26, 95%CI 1.25-4.09) of PTC. For Asians with PTC, the association between the BRAF(V) 600E mutation and pathological features was indicated for advanced TNM stage (OR = 1.56, 95%CI 1.24-1.96) and lymph node metastasis (OR = 1.57, 95%CI 1.25-1.99). For Europeans with PTC, the association between the BRAF(V) 600E mutation and pathological features was indicated for advanced TNM stage (OR = 2.63, 95%CI 2.10-3.30), lymph node metastasis(OR = 1.97, 95%CI 1.19-3.25), and multifocality (OR = 1.35, 95%CI 1.01-1.80).
  
  
  CONCLUSIONS
  There were associations between the BRAF(V) 600E utation and advanced TNM stage, lymph node metastasis, multifocality, and recurrence of PTC.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Kangkang
authors.initials: K
authors.lastname: Yan
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Honghong
authors.initials: H
authors.lastname: Bao
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Longyu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China. Email: liuxin201311@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002291:Carcinoma, Papillary; D006801:Humans; D008207:Lymphatic Metastasis; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D048493:Proto-Oncogene Proteins B-raf