title: Correlation between C-reactive protein in peripheral vein and coronary sinus in stable and unstable angina.
abstract: BACKGROUND
  High sensitivity C-reactive protein (hs-CRP) is commonly used in clinical practice to assess cardiovascular risk. However, a correlation has not yet been established between the absolute levels of peripheral and central hs-CRP.
  
  
  OBJECTIVE
  To assess the correlation between serum hs-CRP levels (mg/L) in a peripheral vein in the left forearm (LFPV) with those in the coronary sinus (CS) of patients with coronary artery disease (CAD) and a diagnosis of stable angina (SA) or unstable angina (UA).
  
  
  METHODS
  This observational, descriptive, and cross-sectional study was conducted at the Instituto do Coração, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, and at the Hospital Beneficência Portuguesa de Sao Paulo, where CAD patients referred to the hospital for coronary angiography were evaluated.
  
  
  RESULTS
  Forty patients with CAD (20 with SA and 20 with UA) were included in the study. Blood samples from LFPV and CS were collected before coronary angiography. Furthermore, analysis of the correlation between serum levels of hs-CRP in LFPV versus CS showed a strong linear correlation for both SA (r = 0.993, p < 0.001) and UA (r = 0.976, p < 0.001) and for the entire sample (r = 0.985, p < 0.001).
  
  
  CONCLUSIONS
  Our data suggest a strong linear correlation between hs-CRP levels in LFPV versus CS in patients with SA and UA.
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Weverton Ferreira
authors.initials: WF
authors.lastname: Leite
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Antonio Franchini
authors.initials: JA
authors.lastname: Ramires
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Luiz Felipe Pinho
authors.initials: LF
authors.lastname: Moreira
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Célia Maria Cassaro
authors.initials: CM
authors.lastname: Strunz
authors.affiliation: Hospital Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Armando
authors.initials: JA
authors.lastname: Mangione
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D060050:Angina, Stable / Q000097:blood*; D000789:Angina, Unstable / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D054326:Coronary Sinus / Q000000981:diagnostic imaging / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values; D012307:Risk Factors; D014680:Veins / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein