title: The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population.
abstract: BACKGROUND
  The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly food frequency questionnaire.
  
  
  RESULTS
  The T allele of the rs7903146 single nucleotide polymorphism (SNP) was associated with lower body weight (p = 0.02), lower BMI (p = 0.009), lower waist circumference (p = 0.01) and a lower waist-to-hip ratio (p = 0.02). The T allele was associated with a significantly higher risk of T2D (odds ratio (OR) (95% confidence interval) = 1.55 (1.09-2.20), p = 0.01) and this association was independent of BMI. When considering the T2D risk, there were nominal interactions between the rs7903146 SNP and dessert (p = 0.05) and milk intakes (p = 0.01). The T2D risk was greater in T allele carriers with high dessert and milk intakes (OR = 2.61 (1.51-4.52), p = 0.0006, and 2.46 (1.47-4.12), p = 0.0006, respectively). In subjects with a high dessert intake, the T allele was also associated with higher fasting plasma glucose concentrations (4.89 ± 0.46 mmol/L in TT subjects, 4.72 ± 0.48 mmol/L in CT subjects and 4.78 ± 0.51 mmol/L in CC subjects; p = 0.03).
  
  
  CONCLUSIONS
  The T allele of the rs7903146 SNP is associated with a significantly higher risk of T2D in an Algerian population. This association was further strengthened by a high dessert intake, suggesting that gene-diet interactions increase the T2D risk.
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. djellouli.ouhaibi@gmail.com.|Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. djellouli.ouhaibi@gmail.com.
authors.forename: Hadjira
authors.initials: H
authors.lastname: Ouhaibi-Djellouli
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. sonia_mediene@yahoo.fr.|Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. sonia_mediene@yahoo.fr.
authors.forename: Sounnia
authors.initials: S
authors.lastname: Mediene-Benchekor
authors.affiliation: Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria. lardjamhetraf.sarah@gmail.com.
authors.forename: Sarah Aïcha
authors.initials: SA
authors.lastname: Lardjam-Hetraf
authors.affiliation: Caisse Nationale des Assurances Sociales des Travailleurs Salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria. amanim20002000@yahoo.fr.
authors.forename: Imane
authors.initials: I
authors.lastname: Hamani-Medjaoui
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. meroufeln@yahoo.fr.
authors.forename: Djabaria Naima
authors.initials: DN
authors.lastname: Meroufel
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. boulenouar.houssam@gmail.com.
authors.forename: Houssam
authors.initials: H
authors.lastname: Boulenouar
authors.affiliation: INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. xavier.hermant@pasteur-lille.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Hermant
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria. nmehtar2002@yahoo.fr.
authors.forename: Nadhira
authors.initials: N
authors.lastname: Saidi-Mehtar
authors.affiliation: INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. philippe.amouyel@pasteur-lille.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.affiliation: Faculté de Médecine, Université Djillali Liabes de Sidi Bel Abbès, Sidi Bel Abbès, Algeria. leilahouti@yahoo.fr.|Laboratoire des Systèmes d'Information en Santé, Université d'Oran, Oran, Algeria. leilahouti@yahoo.fr.
authors.forename: Leila
authors.initials: L
authors.lastname: Houti
authors.affiliation: INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. louisa.goumidi@pasteur-lille.fr.
authors.forename: Louisa
authors.initials: L
authors.lastname: Goumidi
authors.affiliation: INSERM, U744; Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, F-59019, Lille, France. aline.meirhaeghe@pasteur-lille.fr.
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
mesh_terms: D000328:Adult; D000462:Algeria; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005518:Food Preferences; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein