title: MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons.
abstract: Autophagy is a spatially regulated process in axons; autophagosomes form preferentially in the distal axon tip then move actively and processively toward the cell body. Despite the primarily unidirectional transport observed in live-cell imaging experiments, both anterograde-directed KIF5/kinesin-1 motors and retrograde-directed dynein motors are tightly associated with axonal autophagosomes. Here, we discuss our recent work identifying the scaffolding protein MAPK8IP1/JIP1 (mitogen-activated protein kinase 8 interacting protein 1) as a key regulator of autophagosome transport in neurons. MAPK8IP1 tightly coordinates motor activity to ensure the fidelity of retrograde autophagosome transport in the axon.
authors.affiliation: a Department of Physiology ; University of Pennsylvania Perelman School of Medicine ; Philadelphia , PA USA.
authors.forename: Meng-meng
authors.initials: MM
authors.lastname: Fu
authors.forename: Erika L F
authors.initials: EL
authors.lastname: Holzbaur
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D001343:Autophagy; D001369:Axons / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009154:Mutation; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D010588:Phagosomes; D010766:Phosphorylation; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C477012:MAP1LC3A protein, human; C490666:MAPK8IP1 protein, human; D008869:Microtubule-Associated Proteins; C118519:SNAPIN protein, human; D033921:Vesicular Transport Proteins; D016547:Kinesins
keywords: JIP1; LC3; LIR; MKP1; autophagosomes; axonal transport; dynactin; dynein; kinesin; motor regulation