title: Association of IASLC/ATS/ERS Histologic Subtypes of Lung Adenocarcinoma With Epidermal Growth Factor Receptor Mutations in 320 Resected Cases.
abstract: BACKGROUND
  The relationships between the subtypes defined by the new international histologic classification of lung adenocarcinoma (IASLC/ATS/ERS) and epidermal growth factor receptor (EGFR) mutations were studied.
  
  
  METHODS
  We retrospectively reviewed 320 patients with lung adenocarcinoma (162 women, 158 men; mean age, 69 years) who had undergone complete resection, focusing on the new histologic subtypes and EGFR mutations. The clinical stage was IA in 196 patients, IB in 95, IIA in 10, IIB in 10, IIIA in 6, and IV in 3.
  
  
  RESULTS
  The most prevalent subtype was papillary (35.0%), followed by acinar (29.4%), lepidic (13.1%), solid (7.2%), adenocarcinoma in situ (6.6%), minimally invasive adenocarcinoma (6.3%), micropapillary (1.6%), and invasive mucinous adenocarcinoma (1.0%). These subtypes were predictive for both postoperative disease-free and overall survival. EGFR mutations, detected in 40.6% of all cases, were most frequent in acinar (48.4%), followed by minimally invasive adenocarcinoma (45.0%) and papillary (43.8%). They were least frequent in the solid subtype (17.4%). EGFR mutation status did not affect postoperative disease-free or overall survival.
  
  
  CONCLUSIONS
  The outcome after complete resection for lung adenocarcinoma was predicted by the proposed subtype classification. Because EGFR mutations were found in all subtypes, mutation analyses are essential to identify patients with postoperative relapse who would benefit from EGFR-tyrosine kinase inhibitor therapy.
authors.affiliation: Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan. Electronic address: h-nakamura@marianna-u.ac.jp.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Saji
authors.affiliation: Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Takuo
authors.initials: T
authors.lastname: Shinmyo
authors.affiliation: Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Tagaya
authors.affiliation: Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kurimoto
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Koizumi
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takagi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D066246:ErbB Receptors
keywords: Adenocarcinoma; Disease-free survival; EGFR; Lung cancer; Overall survival