title: The "psychomicrobiotic": Targeting microbiota in major psychiatric disorders: A systematic review.
abstract: The gut microbiota is increasingly considered as a symbiotic partner in the maintenance of good health. Metagenomic approaches could help to discover how the complex gut microbial ecosystem participates in the control of the host's brain development and function, and could be relevant for future therapeutic developments, such as probiotics, prebiotics and nutritional approaches for psychiatric disorders. Previous reviews focused on the effects of microbiota on the central nervous system in in vitro and animal studies. The aim of the present review is to synthetize the current data on the association between microbiota dysbiosis and onset and/or maintenance of major psychiatric disorders, and to explore potential therapeutic opportunities targeting microbiota dysbiosis in psychiatric patients.
authors.affiliation: Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France. Electronic address: guillaume.fond@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Fond
authors.affiliation: Jean-Dausset Laboratory & Inserm, UMRS 940, Saint-Louis hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: W
authors.initials: W
authors.lastname: Boukouaci
authors.affiliation: Unité de développement du tissu lymphoïde, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Chevalier
authors.affiliation: Inserm, Institut Pasteur, aviesan/institut multi-organismes immunologie, hématologie et pneumologie (ITMO IHP), bâtiment Biopark, 8, rue de la Croix Jarry 1(er) étage, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Regnault
authors.affiliation: Unité de développement du tissu lymphoïde, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Eberl
authors.affiliation: Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France.
authors.forename: N
authors.initials: N
authors.lastname: Hamdani
authors.affiliation: Stanley Research Program, Sheppard Pratt Health System, 6501N, Charles Street, MD 21204 Baltimore, United States.
authors.forename: F
authors.initials: F
authors.lastname: Dickerson
authors.affiliation: Inserm U1061, academic adult psychiatry department, Montpellier 1 university, La Colombière hospital, Montpellier CHRU, 191, avenue du doyen Gaston-Giraud, 34295 Montpellier cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Macgregor
authors.affiliation: EA 3279-Self-perceived Health Assessment Research Unit, School of Medicine, La Timone University, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France.
authors.forename: L
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France.
authors.forename: A
authors.initials: A
authors.lastname: Dargel
authors.affiliation: Jean-Dausset Laboratory & Inserm, UMRS 940, Saint-Louis hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Oliveira
authors.affiliation: Jean-Dausset Laboratory & Inserm, UMRS 940, Saint-Louis hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Tamouza
authors.affiliation: Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D016503:Drug Delivery Systems / Q000379:methods; D064806:Dysbiosis / Q000150:complications / Q000178:diet therapy* / Q000382:microbiology; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000178:diet therapy* / Q000382:microbiology; D064307:Microbiota / Q000187:drug effects*; D056692:Prebiotics / Q000008:administration & dosage; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D056692:Prebiotics
keywords: Anxiety; Anxiété; Autism; Autisme; Axe intestin-cerveau; Dépression; Microbiota dysbiosis; Microbiote; Métagénome; Probiotic; Probiotique; Prébiotique; Schizophrenia; Thérapeutique; Traitement