title: Sero-surveillance to assess rubella susceptibility and assessment of immunogenicity and reactogenicity of rubella vaccine in Indian girls aged 18-24 years.
abstract: Rubella infection though a mild infection, may cause foetal death or a variety of congenital anomalies. Multiple sero-surveys confirmed that 5-10% women are unexposed to natural or vaccinated rubella virus and remain susceptible to rubella infection. The current study was conducted in 600 girls, aged 18-24 y from Symbiosis International University (SIU), Pune, India to assess their sero-status against rubella infection and to estimate the immunogenicity of rubella vaccine in achieving sero-protective antibody titres. Prior to administration of a single i.m. dose of rubella vaccine (R-vac®) to eligible participants, blood sample (pre-vaccination) was collected. During the 4-6 weeks observation period, adverse events were noted. Then, a second blood sample (post-vaccination) was collected. Significant increase was noted in sero-protection response, viz., 98.6% (post-vaccination) vis-à-vis 66.5% (pre-vaccination); Geometric mean titer (GMT) was significantly higher post-vaccination. Effective measures to introduce rubella vaccination on a larger scale need to be undertaken. An immunization policy with mandatory rubella vaccination for all girls in the reproductive age group and its inclusion in national immunization schedule is highly desirable.
authors.affiliation: a Symbiosis Institute of Health Sciences ; Pune , India.
authors.forename: Deepak S
authors.initials: DS
authors.lastname: Phalgune
authors.forename: Rajiv C
authors.initials: RC
authors.lastname: Yervadekar
authors.forename: Hitt J
authors.initials: HJ
authors.lastname: Sharma
authors.forename: Rajeev M
authors.initials: RM
authors.lastname: Dhere
authors.forename: Sameer S
authors.initials: SS
authors.lastname: Parekh
authors.forename: Alka O
authors.initials: AO
authors.lastname: Chandak
authors.forename: Abhijeet A
authors.initials: AA
authors.lastname: Safai
authors.forename: Sunil D
authors.initials: SD
authors.lastname: Shewale
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007194:India; D012409:Rubella / Q000276:immunology*; D012410:Rubella Syndrome, Congenital / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D012411:Rubella Vaccine; C040901:rubella antibodies
keywords: CRS, congenital rubella syndrome; GMT, geometric mean titer; India; immunogenicity; rubella; safety; sero-survey