title: Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy.
abstract: Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment.
authors.affiliation: Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA, Zui.Pan@osumc.edu.
authors.forename: Zui
authors.initials: Z
authors.lastname: Pan
authors.forename: JianJie
authors.initials: J
authors.lastname: Ma
mesh_terms: D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D006801:Humans; D017136:Ion Transport; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis
chemical_list: D002118:Calcium