title: A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound.
abstract: A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001 Ta-Hsueh Rd., Taiwan, Hsinchu, 300, Republic of China.
authors.forename: Hsin-Yang
authors.initials: HY
authors.lastname: Huang
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Po-Hung
authors.initials: PH
authors.lastname: Hsu
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chiang
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Tsai
authors.forename: Huei-Shang
authors.initials: HS
authors.lastname: Chi
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: You-Yin
authors.initials: YY
authors.lastname: Chen
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D003287:Contrast Media / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D060328:Magnetic Phenomena; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D012822:Silicon Dioxide / Q000737:chemistry; D014465:Ultrasonics
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide
keywords: brain-blood barrier; focused ultrasound; magnetic guidance; nanobubbles