title: Weight gain and associated factors in patients using newer antidepressant drugs.
abstract: OBJECTIVE
  The aim of the present study was to examine weight gain and its association with clinical and sociodemographic characteristics in patients using newer antidepressants.
  
  
  METHODS
  The study had a cross-sectional design. A total of 362 consecutive psychiatric patients taking antidepressant drugs for 6 to 36 months were included in the study.
  
  
  RESULTS
  The prevalence rate of weight gain was 55.2%; 40.6% of the patients had a weight gain of 7% or more compared to the baseline. Overall, antidepressant use was significantly related to increased body weight. Specifically, citalopram, escitalopram, sertraline, paroxetine, venlafaxine, duloxetine and mirtazapine, but not fluoxetine, were associated with significant weight gain. Multivariate logistic regression analysis indicated that lower education status, lower body mass index at the onset of antidepressant use and family history of obesity were independent predictors of weight gain ≥7% compared to the baseline.
  
  
  CONCLUSIONS
  The study results suggest that patients who take newer antidepressants might have significant problems related to body weight.
authors.affiliation: Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey. Electronic address: farukuguz@gmail.com.
authors.forename: Faruk
authors.initials: F
authors.lastname: Uguz
authors.affiliation: Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey. Electronic address: drpekalkan@hotmail.com.
authors.forename: Mine
authors.initials: M
authors.lastname: Sahingoz
authors.affiliation: Department of Psychiatry, Sevket Yilmaz Research and Training Hospital, Bursa, Turkey. Electronic address: buket.gungor@yahoo.com.
authors.forename: Buket
authors.initials: B
authors.lastname: Gungor
authors.affiliation: Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey. Electronic address: fadime_aksoy84@hotmail.com.
authors.forename: Fadime
authors.initials: F
authors.lastname: Aksoy
authors.affiliation: Department of Psychiatry, Sevket Yilmaz Research and Training Hospital, Bursa, Turkey. Electronic address: rustemaskin@gmail.com.
authors.forename: Rustem
authors.initials: R
authors.lastname: Askin
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D000328:Adult; D015283:Citalopram / Q000009:adverse effects; D003511:Cyclohexanols / Q000009:adverse effects; D000068736:Duloxetine Hydrochloride; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives; D008875:Middle Aged; D000078785:Mirtazapine; D017374:Paroxetine / Q000009:adverse effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013876:Thiophenes / Q000009:adverse effects; D000069470:Venlafaxine Hydrochloride; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D015283:Citalopram; D003511:Cyclohexanols; D000068736:Duloxetine Hydrochloride; D005473:Fluoxetine; D008803:Mianserin; D000078785:Mirtazapine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes; D000069470:Venlafaxine Hydrochloride
keywords: Antidepressants; Body mass index; Weight gain