title: Heterogeneity assessment of histological tissue sections in whole slide images.
abstract: Computerized image analysis (IA) can provide quantitative and repeatable object measurements by means of methods such as segmentation, indexation, classification, etc. Embedded in reliable automated systems, IA could help pathologists in their daily work and thus contribute to more accurate determination of prognostic histological factors on whole slide images. One of the key concept pathologists want to dispose of now is a numerical estimation of heterogeneity. In this study, the objective is to propose a general framework based on the diffusion maps technique for measuring tissue heterogeneity in whole slide images and to apply this methodology on breast cancer histopathology digital images.
authors.affiliation: Normandie Université; UNICAEN, CLCC F. Baclesse, PATHIMAGE BioTICLA EA 4656, Caen, France. Electronic address: philippe.belhomme@unicaen.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Belhomme
authors.affiliation: Normandie Université; UNICAEN, CLCC F. Baclesse, PATHIMAGE BioTICLA EA 4656, Caen, France; CIALab, Department of Biomedical Informatics, OSU, Columbus, OH, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Toralba
authors.affiliation: Normandie Université; UNICAEN, CLCC F. Baclesse, PATHIMAGE BioTICLA EA 4656, Caen, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Plancoulaine
authors.affiliation: Normandie Université; UNICAEN, CLCC F. Baclesse, PATHIMAGE BioTICLA EA 4656, Caen, France; Pathology Department, CLCC F. Baclesse, Caen, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Oger
authors.affiliation: CIALab, Department of Biomedical Informatics, OSU, Columbus, OH, USA.
authors.forename: Metin N
authors.initials: MN
authors.lastname: Gurcan
authors.affiliation: Normandie Université; UNICAEN, CLCC F. Baclesse, PATHIMAGE BioTICLA EA 4656, Caen, France; Pathology Department, CLCC F. Baclesse, Caen, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bor-Angelier
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000145:classification* / Q000473:pathology*; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Breast cancer; Dimensionality reduction; Heterogeneity; Spectral graph theory; Whole slide image