title: A novel method for the preparation of a chiral stationary phase containing an enantiopure acridino-18-crown-6 ether selector.
abstract: This paper reports a novel method for the preparation of chiral stationary phases (CSPs) using an acridino-18-crown-6 ether selector as a model compound. Chiral stationary phase (R,R)-CSP- 2A: was obtained by in situ continuously recirculating the solution of carboxyl-substituted acridino-18-crown-6 ether (R,R)- 4: , dicyclohexylcarbodiimide and 3-(triethoxysilyl)propylamine through a high-performance liquid chromatography (HPLC) column containing blank silica gel in elevated pressure and temperature. The enantiomer separating ability of chiral stationary phase (R,R)-CSP- 2A: was investigated by HPLC using mixtures of enantiomers of 1-(1-naphthyl)ethylamine hydrogen perchlorate, 1-(2-naphthyl)ethylamine, 1-(4-bromophenyl)ethylamine and 1-(4-nitrophenyl)ethylamine hydrogen chloride. The best results were found for the separation of the mixtures of enantiomers of Br-PEA.
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, Budapest H-1521, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Németh
authors.affiliation: Compound Profiling Laboratory, Chemical Works of Gedeon Richter Plc., PO Box 27, Budapest H-1475, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Lévai
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, Budapest H-1521, Hungary Compound Profiling Laboratory, Chemical Works of Gedeon Richter Plc., PO Box 27, Budapest H-1475, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Fődi
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, Budapest H-1521, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Kupai
authors.affiliation: Medicinal Chemistry Laboratory II, Chemical Works of Gedeon Richter Plc., PO Box 27, Budapest H-1475, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Túrós
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, Budapest H-1521, Hungary.
authors.forename: Tünde
authors.initials: T
authors.lastname: Tóth
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, Budapest H-1521, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Huszthy
authors.affiliation: Compound Profiling Laboratory, Chemical Works of Gedeon Richter Plc., PO Box 27, Budapest H-1475, Hungary gy.balogh@richter.hu.
authors.forename: György Tibor
authors.initials: GT
authors.lastname: Balogh
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D043844:Crown Ethers / Q000737:chemistry*; D004986:Ether / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D043844:Crown Ethers; D004986:Ether; D058428:Silica Gel; C015762:18-crown-6