title: The mitochondrial DNA history of a former native American village in northern Uruguay.
abstract: OBJECTIVE
  In 1828, between 8,000 and 15,000 Indians from the Jesuit Missions were brought to Uruguay. There, they were settled in a village, presently named Bella Unión, in the northwest corner of the country. According to historic sources, the Indians abandoned the settlement shortly thereafter, with the village subsequently repopulated by "criollos" and immigrants from abroad. As a first approach to reconstruct the genetic history of the population, data about the living population genetic structure will be used. Based on the analysis of the maternal lineages of the inhabitants of Bella Unión, and of those from two nearby villages, we expect to partially answer what happened with the first and subsequent inhabitants.
  
  
  METHODS
  We analyzed the maternal lineages of the present inhabitants of Bella Unión and neighboring localities through the sequencing of the mitochondrial DNA control region.
  
  
  RESULTS
  A total of 64.3%, 5.7%, and 30% of the mtDNAs were of Native, African, and West Eurasian origin, respectively. These figures are quite similar to that of the population of Tacuarembó, which is located in northeastern Uruguay. The four main Native American founding haplogroups were detected, with B2 being the most frequent, while some rare subhaplogroups (B2h, C1b2, D1f1) were also found. When compared with other Native American sequences, near- matches most consistently pointed to an Amazonian Indian origin which, when considered with historical evidence, suggested a probable Guaraní-Missionary-related origin.
  
  
  CONCLUSIONS
  The data support the existence of a relationship between the historic and present inhabitants of the extreme northwest Uruguay, with a strong contribution of Native Americans to the mitochondrial DNA diversity observed there.
authors.affiliation: Departamento de Antropología Biológica, Facultad de Humanidades y Ciencias de la Educación, Universidad de la República, Montevideo, Uruguay.
authors.forename: Mónica
authors.initials: M
authors.lastname: Sans
authors.forename: Pablo
authors.initials: P
authors.lastname: Mones
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Figueiro
authors.forename: Isabel
authors.initials: I
authors.lastname: Barreto
authors.forename: Josefina M B
authors.initials: JM
authors.lastname: Motti
authors.forename: Michael D
authors.initials: MD
authors.lastname: Coble
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Bravi
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Hidalgo
mesh_terms: D044383:Black People / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014583:Uruguay; D044465:White People / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial