title: An epigenetic therapy for diffuse intrinsic pontine gliomas.
abstract: Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Vijay
authors.initials: V
authors.lastname: Ramaswamy
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Remke
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology*; D020295:Brain Stem Neoplasms / Q000235:genetics*; D049109:Cell Proliferation / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics*; D006657:Histones / Q000187:drug effects*; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000494:pharmacology*
chemical_list: D001552:Benzazepines; C000593030:GSK-J4; D006657:Histones; D011743:Pyrimidines; D056484:Jumonji Domain-Containing Histone Demethylases; C524220:KDM6B protein, human