title: Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis.
abstract: Five new cyclic peptides (including four heptapeptides and one octapeptide), reniochalistatins A-E (1-5), were isolated and characterized from the marine sponge Reniochalina stalagmitis collected off Yongxing Island in the South China Sea. Their structures were assigned on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MALDI-TOF/TOF data for sequence analysis. The absolute configurations of all of the amino acid residues were determined using chiral-phase HPLC and Marfey's analysis. The cyclic octapeptide reniochalistatin E showed biological activity in various cytotoxicity assays employing different tumor cell lines (RPMI-8226, MGC-803, HL-60, HepG2, and HeLa).
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
authors.forename: Kai-Xuan
authors.initials: KX
authors.lastname: Zhan
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Li
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C000595536:reniochalistatin E; D004317:Doxorubicin