title: Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals.
abstract: BACKGROUND
  The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities.
  
  
  METHODS
  The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed. The correlations of oncologic endpoints with tumor parameters and primary treatment were evaluated.
  
  
  RESULTS
  The overall survival (OS) rate was 76% and the disease-specific survival (DSS) rate was 80% at 3 years in the entire group. Sex and T and N classifications significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and radiotherapy (RT), and the temporal sequence of the 2 modalities did not affect prognosis.
  
  
  CONCLUSIONS
  The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in univariate and multivariate analyses for any stage considered.
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bussu
authors.affiliation: Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Mura
authors.affiliation: Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Miccichè
authors.affiliation: Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bertino
authors.affiliation: Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Occhini
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Almadori
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Galli
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Manlio
authors.initials: M
authors.lastname: Pandolfini
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallus
authors.affiliation: Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Autorino
authors.affiliation: Institute of Anesthesiology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Maria Lavinia
authors.initials: ML
authors.lastname: Guidi
authors.affiliation: Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Dinapoli
authors.affiliation: Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
authors.affiliation: Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Benazzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006785:Hospitals, University; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D007558:Italy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D016896:Treatment Outcome
keywords: hypopharyngeal squamous cell carcinoma; multidisciplinary approach; primary treatment; radiotherapy; surgery