title: Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover pilot study.
authors.affiliation: Department of Dermatology, Chiba University Graduate School of Medicine, Japan.
authors.forename: Yaei
authors.initials: Y
authors.lastname: Togawa
authors.affiliation: Department of Dermatology, Chiba University Graduate School of Medicine, Japan. Electronic address: nkambe@faculty.chiba-u.jp.
authors.forename: Naotomo
authors.initials: N
authors.lastname: Kambe
authors.affiliation: Department of Pediatrics, Chiba University Graduate School of Medicine, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimojo
authors.affiliation: Department of Pediatrics, Chiba University Graduate School of Medicine, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Nakano
authors.affiliation: Clinical Research Center, Chiba University Hospital, Chiba, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mochizuki
authors.affiliation: Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Department of Dermatology, Chiba University Graduate School of Medicine, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsue
mesh_terms: D002118:Calcium / Q000032:analysis; D002675:Child, Preschool; D018592:Cross-Over Studies; D003876:Dermatitis, Atopic / Q000503:physiopathology / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008274:Magnesium / Q000032:analysis; D008297:Male; D010865:Pilot Projects; D014867:Water / Q000737:chemistry*; D014880:Water Softening
chemical_list: D014867:Water; D008274:Magnesium; D002118:Calcium
keywords: Atopic dermatitis; Out-in skin transparency; Skin barrier function; Ultra-pure soft water