title: Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers.
abstract: BACKGROUND
  Women with BRCA1 and BRCA2 mutation carriers are at substantially elevated risk of developing ovarian cancer. The aim of the meta-analysis is to clarify the role of risk-reducing salpingo-oophorectomy (RRSO) to reduce ovarian cancer risk and mortality in women with BRCA 1 and BRCA 2 mutation carriers.
  
  
  METHODS
  Pubmed, Medline and Scopus were searched to select English-language articles. Two investigators independently extracted characteristics and results of selected studies. Articles were included only if prospective and if absolute numbers of ovarian cancer and death events were available or derivable from the test. Pooled hazard ratio (HR) with 95% confidence interval (CI) was calculated using fixed effects model.
  
  
  RESULTS
  Meta-analysis of 3 prospective studies demonstrated a significant risk reduction of ovarian cancer with RRSO in BRCA 1 and BRCA 2 mutation carriers, as well as benefit in all-causes mortality incidence.
  
  
  CONCLUSIONS
  It may be justified to recommend RRSO to reduce ovarian cancer risk and all-causes mortality in women with a mutation in BRCA 1 and BRCA 2.
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. clamarchetti@libero.it.
authors.forename: Claudia
authors.initials: C
authors.lastname: Marchetti
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. fradefelice@hotmail.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: De Felice
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. innocenza.palaia@uniroma1.it.
authors.forename: Innocenza
authors.initials: I
authors.lastname: Palaia
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. claudia.marchetti@uniroma1.it.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Perniola
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. angela.musella@gmail.com.
authors.forename: Angela
authors.initials: A
authors.lastname: Musella
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. daniela.musio@libero.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Musio
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. ludovico.muzii@uniroma1.it.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Muzii
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. vincenzo.tombolini@uniroma1.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Tombolini
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. pierluigi.benedettipanici@uniroma1.it.
authors.forename: Pierluigi Benedetti
authors.initials: PB
authors.lastname: Panici
mesh_terms: D002423:Cause of Death; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006579:Heterozygote; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000517:prevention & control; D010052:Ovariectomy; D011322:Primary Prevention / Q000379:methods; D012307:Risk Factors; D040242:Risk Reduction Behavior; D058994:Salpingectomy