title: Nuclease-containing media for resettable operation of DNA logic gates.
abstract: We designed and tested a system that allows DNA logic gates to respond multiple times to the addition of oligonucleotide inputs. After producing an output signal, the system spontaneously resets to the background state. This system does not require any operator action to achieve reset of a DNA logic gate, and may become useful for construction of reusable DNA-based computational devices.
authors.affiliation: Chemistry Department, University of Central Florida, Orlando, FL 32816, USA. dmk2111@gmail.com.
authors.forename: Martin R
authors.initials: MR
authors.lastname: O'Steen
authors.forename: Evan M
authors.initials: EM
authors.lastname: Cornett
authors.forename: Dmitry M
authors.initials: DM
authors.lastname: Kolpashchikov
mesh_terms: D039301:Computers, Molecular; D005090:Exodeoxyribonucleases / Q000737:chemistry; D008128:Logic; D009841:Oligonucleotides / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; D005090:Exodeoxyribonucleases