title: The clinical pharmacology of traditional antiepileptic drugs.
abstract: Despite the availability of newer agents, a number of antiepileptic drugs have continued to be employed reasonably widely, many years after their introduction to human therapeutics. These drugs comprise phenobarbitone and some of its congeners, phenytoin, ethosuximide, carbamazepine, valproate, and certain benzodiazepines. Details of their pharmacological profiles are outlined in the following account.
authors.affiliation: Department of Medicine, Neurology, University of Melbourne, Melbourne.
authors.forename: Frank J E
authors.initials: FJ
authors.lastname: Vajda
authors.affiliation: School of Health, Biomedical Science, University of Queensland, Brisbane, Australia.
authors.forename: Mervyn J
authors.initials: MJ
authors.lastname: Eadie
mesh_terms: D000927:Anticonvulsants / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans
chemical_list: D000927:Anticonvulsants
keywords: benzodiazepines; carbamazepine; ethosuximide; mechanism of action; pharmacokinetics; phenobarbitone; phenytoin; valproate