title: Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation.
abstract: Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57 NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.
authors.affiliation: aDepartment of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne bBurnet Institute, Melbourne cMelbourne Sexual Health Centre, Carlton, Victoria, Australia.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Parsons
authors.forename: Liyen
authors.initials: L
authors.lastname: Loh
authors.forename: Shayarana
authors.initials: S
authors.lastname: Gooneratne
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Center
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kent
mesh_terms: D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation
chemical_list: D015483:HIV Antibodies