title: A curcumin-based TPA four-branched copper(II) complex probe for in vivo early tumor detection.
abstract: A multibranched Cu(II) complex CuL2 curcumin-based was synthesized and characterized by single-crystal X-ray diffraction analysis. The photophysical properties of the complex have been investigated both experimentally and theoretically. The results show that the target complex exhibits higher quantum yield and larger two-photon absorption (TPA) cross-section in the near infrared (NIR) region compared with its free ligand. The cell imaging studies in vitro and in vivo reveal that the complex shows good photostability and excellent tumor targeting capability to tested cancerous cells, which can be potentially used for early tumor detection.
authors.affiliation: Department of Chemical and Chemical Engineering, Hefei Normal University, Hefei 230001, PR China.
authors.forename: Zongxin
authors.initials: Z
authors.lastname: Pi
authors.affiliation: Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, PR China.
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Chemical and Chemical Engineering, Hefei Normal University, Hefei 230001, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, PR China; Center of Modern Experimental Technology, Anhui University, Hefei 230038, PR China. Electronic address: zshuangsheng@126.com.
authors.forename: Shuangsheng
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D003474:Curcumin / Q000737:chemistry*; D042241:Early Diagnosis; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009369:Neoplasms / Q000175:diagnosis*; D019265:Spectroscopy, Near-Infrared
chemical_list: D003474:Curcumin
keywords: Cell imaging; Crystal structure; Early tumor detection; Multi-branched Cu(II) complex; Photophysical property