title: [A negative correlation between B7-H3 expression and the number of CD8+ T cell infiltration in primary hepatocellular carcinoma tissues].
abstract: OBJECTIVE
  To investigate the relationship between B7-H3 expression and the number of CD8(+) T cell infiltration in primary hepatocellular carcinoma (HCC) tissues.
  
  
  METHODS
  The level of B7-H3 expression and the number of CD8(+) T cell infiltration in primary HCC were determined using immunohistochemical staining, and then the correlation between them was analyzed statistically.
  
  
  RESULTS
  The immunohistochemical staining showed that the high expression of B7-H3 was found in 26 cases (41.3%), and the low expression in 37 cases (58.7%) of the 63 primary HCC. Fifty-seven cases (90.5%) were positive for B7-H3 expression in HCC tissues, and normal hepatocellular tissues hardly expressed B7-H3 molecules. The number of infiltrating CD8(+) T cells in B7-H3 high expression group was less than that in B7-H3 low expression group. B7-H3 expression was negatively correlated with the number of infiltrating CD8(+) T cells in HCC tissues. Moreover, both B7-H3 expression and CD8(+)T cell infiltration were related with clinical stage, local lymph node metastasis and distant metastasis in HCC patients.
  
  
  CONCLUSIONS
  B7-H3 molecules were highly expressed and negatively correlated with CD8(+) T cell infiltration in primary HCC tissues.
authors.affiliation: Basic Medical College, Binzhou Medical University, Yantai 264003, China.
authors.forename: Tongshen
authors.initials: T
authors.lastname: Liu
authors.affiliation: Affiliated Hospital, Binzhou Medical University, Binzhou 256603, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Qianfoshan Hospital, Jinan 250014, China.
authors.forename: Guangyun
authors.initials: G
authors.lastname: Li
authors.affiliation: Yuhuangding Hospital, Yantai 264000, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Yu
authors.affiliation: Basic Medical College, Binzhou Medical University, Yantai 264003, China.
authors.forename: Xiying
authors.initials: X
authors.lastname: Luan
mesh_terms: D000328:Adult; D000368:Aged; D060887:B7 Antigens / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D060887:B7 Antigens; C423237:CD276 protein, human