title: Hispidacine, an unusual 8,4'-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
abstract: Hispidacine, an 8,4'-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.
authors.affiliation: School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: Veronica Alicia
authors.initials: VA
authors.lastname: Yap
authors.affiliation: Department of Biomedical Sciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: Bi-Juin
authors.initials: BJ
authors.lastname: Loong
authors.affiliation: Department of Biomedical Sciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: Kang-Nee
authors.initials: KN
authors.lastname: Ting
authors.affiliation: School of Biosciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: Sandy Hwei-San
authors.initials: SH
authors.lastname: Loh
authors.affiliation: Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Kien-Thai
authors.initials: KT
authors.lastname: Yong
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yun-Yee
authors.initials: YY
authors.lastname: Low
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
authors.affiliation: School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address: KuanHon.Lim@nottingham.edu.my.
authors.forename: Kuan-Hon
authors.initials: KH
authors.lastname: Lim
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001011:Aorta / Q000187:drug effects; D045744:Cell Line, Tumor; D030681:Ficus / Q000737:chemistry*; D006801:Humans; D054836:Indolizidines / Q000737:chemistry / Q000302:isolation & purification; D007212:Indolizines / Q000737:chemistry / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D008297:Male; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry / Q000302:isolation & purification; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D054836:Indolizidines; D007212:Indolizines; D017705:Lignans; D010618:Phenanthrolines; D014665:Vasodilator Agents; C000598226:hispidacine; C000598227:hispiloscine; C521640:phenanthroindolizidine
keywords: Alkaloids; Antiproliferation; Ficus hispida; Moraceae; NMR; Neolignans; Phenanthroindolizidine; Vasorelaxation