title: Efficacy and safety of porcine collagen filler for nasolabial fold correction in Asians: a prospective multicenter, 12 months follow-up study.
abstract: Recently, injectable dermal fillers have become important alternatives to surgical procedures for the correction of facial wrinkles. Bovine collagen is the first approved material for filler injection, and several studies have shown its efficacy. However, the risk of developing an allergic reaction and xenogenic transmission of bovine spongiform encephalopathy remain among its disadvantages. In this randomized, double-blinded, split-face study, we compared the efficacy and safety of a porcine collagen filler (TheraFill®) with that of a bovine collagen filler (KOKEN®) for nasolabial fold correction. A total of sixty one patients with mild to severe nasolabial fold were randomized to receive TheraFill® and KOKEN® on contralateral sides of the face. During the 12-month follow-up period, improvement in the Wrinkle-Severity Rating Scale score was slightly higher in TheraFill® group than KOKEN® group, although the difference was not statistically significant. No serious adverse reactions were observed and both materials were tolerable in most cases. In conclusion, the long-term effect of TheraFill® on nasolabial fold correction was comparable to that of KOKEN®, and it may be a good alternative to bovine collagen filler.
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jung Ho
authors.identifier: 0000-0002-3800-5494
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yong Sung
authors.identifier: 0000-0002-6108-758X
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sue Min
authors.identifier: 0000-0002-0894-5207
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Young Jin
authors.identifier: 0000-0002-9046-9907
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jong Won
authors.identifier: 0000-0002-9398-8059
authors.initials: JW
authors.lastname: Rhie
authors.affiliation: Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Young Joon
authors.identifier: 0000-0002-2678-9092
authors.initials: YJ
authors.lastname: Jun
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D002417:Cattle; D003094:Collagen / Q000009:adverse effects / Q000627:therapeutic use*; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D004311:Double-Blind Method; D005145:Face / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold / Q000601:surgery*; D011446:Prospective Studies; D015595:Skin Aging; D013518:Surgery, Plastic / Q000379:methods*; D013552:Swine; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D003094:Collagen
keywords: Bovine Collagen; Filler; Nasolabial Fold; Porcine Collagen