title: Correlation of the volume of ectopic pregnancy and MTX therapy outcome: a retrospective cohort study.
abstract: OBJECTIVE
  To investigate a possible correlation between the volume of the tubal ectopic pregnancy (EP) measured by vaginal-ultrasound (VUS) and methotrexate (MTX) therapy outcome.
  
  
  METHODS
  Data of EP volume measured by one expert-sonographer, viability, clinical symptoms, previous IVF/insemination, follow-up of β-hCG and progesterone levels, and treatment of EP was collected of 100 patients with sonographically diagnosed EP, who attended the Department of Obstetrics and Gynecology of the Medical University Vienna between March 2008 and September 2011.
  
  
  RESULTS
  The mean volume of EP (mVol.) in the group with successful MTX therapy (n = 38) was 5.11 ml, 95%CI [2.4; 7.8] with a median 3.2 ml, IQR [5.0], in the group with unsuccessful MTX treatment (n = 11) it was 15.24 ml, 95%CI [-2.6; 33.1], with a median 4.4 ml, IQR [11.4]. We could observe a trend towards a lower mVol. in the successful MTX group (5.11 ml vs. 15.24 ml). We could not show a significant correlation (u-test p = 0.208).
  
  
  CONCLUSIONS
  A clear tendency was observed towards a lower mVol. in the successful MTX therapy group, but we could not verify a statistically significant correlation of volume of EP and MTX therapy outcome most likely due to the small sample size. This was the first study investigating the correlation of volume of EP and MTX therapy outcome as principal question.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Helmy
authors.affiliation: Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Koch
authors.affiliation: Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Kölbl
authors.affiliation: Medical University Vienna, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Grohmann-Izay
authors.affiliation: Department of Gynecology, Obstetrics and Reproductive Medicine, University Clinics of Saarland, Homburg/Saar, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Solomayer
authors.affiliation: Department of Gynecology, Obstetrics and Reproductive Medicine, University Clinics of Saarland, Homburg/Saar, Germany. Electronic address: bader.yvonne@gmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Bader
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011374:Progesterone / Q000097:blood; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011374:Progesterone; D008727:Methotrexate
keywords: Beta hCG; Ectopic pregnancy; Ectopic pregnancy volume; Methotrexate; Progesterone