title: Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios.
abstract: OBJECTIVE
  To evaluate the association between orexin-A level and idiopathic polyhydramnios.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Tertiary-level university hospital.
  
  
  METHODS
  Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels.
  
  
  METHODS
  Amniotic fluid level was measured at admission for delivery using enzyme-linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta.
  
  
  METHODS
  Maternal and umbilical levels of orexin-A.
  
  
  RESULTS
  Mean umbilical serum orexin-A level was significantly lower than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin-A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin-A level was observed between the two groups.
  
  
  CONCLUSIONS
  Idiopathic polyhydramnios was associated with decreased umbilical serum orexin-A levels. Our results provide evidence that orexin-A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Geum Joon
authors.initials: GJ
authors.lastname: Cho
authors.forename: Hye-Ri
authors.initials: HR
authors.lastname: Hong
authors.forename: Suhng Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Soon Cheol
authors.initials: SC
authors.lastname: Hong
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Oh
authors.forename: Hai Joon
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D000068797:Orexins; D006831:Polyhydramnios / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D012016:Reference Values; D056910:Republic of Korea; D047929:Term Birth / Q000378:metabolism; D014470:Umbilical Cord / Q000378:metabolism*
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins
keywords: Orexin-A; amniotic fluid; placenta; polyhydramnios; umbilical cord