title: Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review of the literature.
abstract: OBJECTIVE
  The aim of this systematic review was to assess the efficacy of bioactive glass (BG) in bone regeneration for implant site development procedures.
  
  
  METHODS
  The following specific question was formulated with reference to Population, Intervention, Control, Outcomes (PICO): "In persons that undergo bone regeneration surgeries for implant site development, what histological outcomes does the use of BG yield, alone or in combination with AB, compared to positive or negative controls?".
  
  
  RESULTS
  The 1st phase of screening yielded 400 titles and abstracts. A total of 12 studies reporting on the use of bioactive glass were scrutinized for inclusion in the final analysis and 5 studies were selected for qualitative synthesis of the results. Data were divided into two categories: ridge preservation (n = 2) and sinus augmentation (n = 3).
  
  
  CONCLUSIONS
  Within the limitations of this review, it can be concluded that (1) the combination of BG with AB chips in a 1:1 ratio is an efficacious treatment modality for direct sinus augmentation, with histological results comparable to 100 % AB. (2) When used for ridge preservation, BG yields a high percentage of true bone regeneration. (3) Currently, no reliable controlled studies report histological outcomes from the use of BG in ridge augmentation procedures.
  
  
  CONCLUSIONS
  Clinicians may consider BG bone substitutes as efficacious alternatives for ridge preservation and sinus augmentation surgical procedures. Further controlled clinical studies are warranted to determine if bone-to-implant contact is improved in BG-grafted sites versus controls.
authors.affiliation: Advanced Education Program in Periodontology, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN, 55455, USA.
authors.forename: Andreas L
authors.initials: AL
authors.lastname: Ioannou
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Kotsakis
authors.forename: Tarun
authors.initials: T
authors.lastname: Kumar
authors.forename: James E
authors.initials: JE
authors.lastname: Hinrichs
authors.forename: Georgios
authors.initials: G
authors.lastname: Romanos
mesh_terms: D001861:Bone Regeneration; D005898:Glass; D006801:Humans; D019736:Prostheses and Implants