title: Update on pancreatic neuroendocrine tumors.
abstract: Pancreatic neuroendocrine tumors (pNETs) are relatively rare tumors comprising 1-2% of all pancreas neoplasms. In the last 10 years our understanding of this disease has increased dramatically allowing for advancements in the treatment of pNETs. Surgical excision remains the primary therapy for localized tumors and only potential for cure. New surgical techniques using laparoscopic approaches to complex pancreatic resections are a major advancement in surgical therapy and increasingly possible. With early detection being less common, most patients present with metastatic disease. Management of these patients requires multidisciplinary care combining the best of surgery, chemotherapy and other targeted therapies. In addition to surgical advances, recently, there have been significant advances in systemic therapy and targeted molecular therapy.
authors.affiliation: Department of Surgery, University of Colorado, Academic Office One, Aurora, CO, USA.
authors.forename: Logan R
authors.initials: LR
authors.lastname: McKenna
authors.affiliation: Department of Surgery, University of Colorado, Academic Office One, Aurora, CO, USA.
authors.forename: Barish H
authors.initials: BH
authors.lastname: Edil
keywords: Pancreatic neuroendocrine tumor (pNET); islet cell tumor; laparoscopic pancreas surgery; liver metastases; neuroendocrine neoplasm; pancreas; pancreas cancer; surgical therapy; targeted therapy