title: A novel thermal and pH responsive drug delivery system based on ZnO@PNIPAM hybrid nanoparticles.
abstract: A smart ZnO@PNIPAM hybrid was prepared by grafting thermal responsive poly(N-isopropylacrylamide) (PNIPAM) on zinc oxide (ZnO) nanoparticles via surface-initiated atom transfer radical polymerization (ATRP). The thermal gravimetric analysis (TGA) shows that the grafting amount of PNIPAM was about 38%, and the SEM images show that the PNIPAM chains can prevent the aggregation of ZnO nanoparticles. The responsive properties of ZnO@PNIPAM were measured by photoluminescence spectra, and the results demonstrate that the PNIPAM chains grafted on ZnO surfaces can realize reversible thermal responsive and photoluminescence properties. An anticancer drug, doxorubicin (Dox), was used as a model drug and loaded into the hybrid nanoparticles, and an in vitro drug release test implied that ZnO@PNIPAM could work as a thermal responsive drug delivery system. Furthermore, pH sensitive drug releases were carried out in acetate buffer at pH 5.0 and pH 6.0 and in water at pH7.0, and the results showed evident pH dependency, showing its pH responsive properties.
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Licheng
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 220 Handan Road, Shanghai 200433, China. Electronic address: weijunchao@ncu.edu.cn.
authors.forename: Junchao
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Peng
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D057446:Hydrodynamics; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013696:Temperature; D013818:Thermogravimetry; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C052970:poly-N-isopropylacrylamide; D004317:Doxorubicin; D015034:Zinc Oxide
keywords: ATRP; Drug delivery; Surface modification; Thermal responsive; ZnO