title: Physicochemical and biological properties of oxovanadium(IV), cobalt(II) and nickel(II) complexes with oxydiacetate anions.
abstract: The potentiometric and conductometric titration methods have been used to characterize the stability of series of VO(IV)-, Co(II)- and Ni(II)-oxydiacetato complexes in DMSO-water solutions containing 0-50 % (v/v) DMSO. The influence of DMSO as a co-solvent on the stability of the complexes as well as the oxydiacetic acid was evaluated. Furthermore, the reactivity of the complexes towards superoxide free radicals was assessed by employing the nitro blue tetrazolium (NBT) assay. The biological properties of the complexes were investigated in relation to their cytoprotective activity against the oxidative damage generated exogenously by using hydrogen peroxide in the Human Dermal Fibroblasts adult (HDFa) cell line as well as to their antimicrobial activity against the bacteria (Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis). The relationship between physicochemical and biological properties of the complexes was discussed.
authors.affiliation: Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland, dariusz.wyrzykowski@ug.edu.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wyrzykowski
authors.forename: Anna
authors.initials: A
authors.lastname: Kloska
authors.forename: Joanna
authors.initials: J
authors.lastname: Pranczk
authors.forename: Aneta
authors.initials: A
authors.lastname: Szczepańska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tesmar
authors.forename: Dagmara
authors.initials: D
authors.lastname: Jacewicz
authors.forename: Bogusław
authors.initials: B
authors.lastname: Pilarski
authors.forename: Lech
authors.initials: L
authors.lastname: Chmurzyński
mesh_terms: D000838:Anions / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014638:Vanadates / Q000737:chemistry*
chemical_list: D000838:Anions; D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; C075743:oxovanadium IV; D003035:Cobalt; D014638:Vanadates; D009532:Nickel