title: Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives.
abstract: G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA or RNA secondary structures that are formed in guanine-rich sequences. They are widely distributed in functional regions of the human genome, such as telomeres, ribosomal DNA (rDNA), transcription start sites, promoter regions and untranslated regions of mRNA, suggesting that G-quadruplex structures may play a pivotal role in the control of a variety of cellular processes. G-Quadruplexes are viewed as valid therapeutic targets in human cancer diseases. Small molecules, from naturally occurring to synthetic, are exploited to specifically target G-quadruplexes and have proven to be a new class of anticancer agents. Notably, alkaloids are an important source of G-quadruplex ligands and have significant bioactivities in anticancer therapy. In this review, the authors provide a brief, up-to-date summary of heterocyclic alkaloids and their derivatives targeting G-quadruplexes.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Xiong
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Zhi-Shu
authors.initials: ZS
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: tanjiah@mail.sysu.edu.cn.
authors.forename: Jia-Heng
authors.initials: JH
authors.lastname: Tan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D012313:RNA; D004247:DNA
keywords: Alkaloid derivative; Anti-cancer; Bioactivity; G-Quadruplex; Heterocyclic alkaloid