title: Bare platinum coils vs. HydroCoil in the treatment of unruptured intracranial aneurysms-A single center randomized controlled study.
abstract: OBJECTIVE
  The HydroCoil Embolic System (HES) was developed to improve aneurysm filling to provide superior occlusion efficacy, reduce retreatment rates and enhance long-term durability. We performed a randomized clinical trial to compare the effectiveness of bare platinum coils (BPC) vs. HES for unruptured intracranial aneurysms.
  
  
  METHODS
  Ninety-six patients underwent endovascular coiling of unruptured intracranial aneurysms. The aneurysms were randomized equally to receive BPC or HES. Immediate angiographic results, number of coils used and complications were evaluated and all cases had 12-month follow-up angiography.
  
  
  RESULTS
  Immediate angiographic results demonstrated that 84.0% of aneurysms treated with HES were completely occluded compared to 76.1% of aneurysms treated with BPC (p=0.3310). The mean number of coils utilized to fill the aneurysm was significantly lower in the HES arm (5.04 vs. 6.93). Additional adjunctive techniques were performed in 51.1% of all cases. There were seven patients (7.3%) with postoperative complications during the study period. The coil type used during the treatment did not demonstrate any significant differences on the overall recurrence rate (HES - 18.0%, BPC - 17.4%, p=0.9712). There was a statistically significant difference in the aneurysm size and the neck width between completely occluded aneurysms and aneurysms with residual flow in both immediate angiographic and mid-term follow-up.
  
  
  CONCLUSIONS
  Overall, aneurysm size and neck width are the main risk factors associated with aneurysm recurrence. HES compared to BPC required less total number of coils to provide a denser aneurysm filling. However, there were equivocal results with both devices, at the mid-term angiographic follow-up.
authors.affiliation: Departament of Interventional Radiology, Pomeranian Medical University, Neurointerventional Cath Lab MSW Hospital, Al. Powst. Wielkopolskich 72, 70-111 Szczecin, Poland. Electronic address: wponcyl@poczta.onet.pl.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Poncyljusz
authors.affiliation: Department of Neurosurgery and Pediatric Neurosurgery, Pomeranian Medical University, Unii Lubelskiej 1, 71-242 Szczecin Poland. Electronic address: arturzarzycki@o2.pl.
authors.forename: Artur
authors.initials: A
authors.lastname: Zarzycki
authors.affiliation: Departament of Interventional Radiology, Pomeranian Medical University, Neurointerventional Cath Lab MSW Hospital, Al. Powst. Wielkopolskich 72, 70-111 Szczecin, Poland. Electronic address: zwarzany@gmail.com.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Zwarzany
authors.affiliation: Microvention-Terumo, Tustin, CA, USA. Electronic address: tom.burke@microvention.com.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Burke
mesh_terms: D000792:Angiography / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010984:Platinum; D011474:Prosthesis Design; D012008:Recurrence; D019233:Retreatment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010984:Platinum
keywords: Embolization; HydroCoil; Intracranial aneurysm; Platinum coil