title: In vivo assessment of the effect of taxifolin glycoside on atopic dermatitis-like skin lesions using biomedical tools in NC/Nga mice.
abstract: BACKGROUND
  Noninvasive methods of assessment are widely used in clinical trials. However, such methods have not been established in atopic dermatitis (AD), which is a chronic inflammatory skin disease.
  
  
  OBJECTIVE
  To demonstrate, using biomedical tools, the benefits of a new substance, taxifolin glycoside (TAX), in an AD model, the NC/Nga mouse.
  
  
  METHODS
  We evaluated the efficacy of topical TAX for AD by measuring clinical skin severity score, cytokine expression and serum IgE level, and by using biomedical measures (vapometry and corneometry). Topical TAX was applied to AD-induced NC/Nga mice for 3 weeks. The anti-inflammatory effects of this compound were demonstrated noninvasively using biomedical tools and immunological assays.
  
  
  RESULTS
  Our method of AD assessment using biomedical tools is more objective and accurate than visual inspection. The results obtained using the biomedical tools were identical to those obtained using immunological assays.
  
  
  CONCLUSIONS
  In vivo biomedical tools are useful for diagnosing and monitoring treatment effects in AD.
authors.affiliation: Research Institute for Skin Imaging, College of Medicine, Korea University, Seoul, Korea.|Biomedical Engineering, Biomedical Science of Brain Korea 21, Korea Universitiy, Seoul, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Radiological Science, College of Natural Science, Gimcheon University, Gyeongbuk, Korea.
authors.forename: O S
authors.initials: OS
authors.lastname: Lee
authors.affiliation: Department of Nursing, School of Health, Chungbuk Health and Science University, Chungbuk, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Ha
authors.affiliation: Department of Dermatology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Research Institute for Skin Imaging, College of Medicine, Korea University, Seoul, Korea.
authors.forename: G
authors.initials: G
authors.lastname: Park
authors.affiliation: Medical Engineering R&D Center, ASAN Medical Center, Seoul, Korea.
authors.forename: J K
authors.initials: JK
authors.lastname: Kim
authors.affiliation: Research Institute for Skin Imaging, College of Medicine, Korea University, Seoul, Korea.|Biomedical Engineering, Biomedical Science of Brain Korea 21, Korea Universitiy, Seoul, Korea.|Department of Dermatology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D007073:Immunoglobulin E / Q000097:blood; D051379:Mice; D011794:Quercetin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014870:Water Loss, Insensible / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D007073:Immunoglobulin E; D011794:Quercetin; C003377:taxifolin