title: Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction.
abstract: Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
authors.affiliation: Departamento de Química Universidade Federal de Santa Catarina FlorianópolisSC Brazil Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Marcus Mandolesi
authors.initials: MM
authors.lastname: Sá
authors.affiliation: Departamento de Química Universidade Federal de Santa Catarina FlorianópolisSC Brazil Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Misael
authors.initials: M
authors.lastname: Ferreira
authors.affiliation: Faculdade de Ciências Farmacêuticas Universidade Federal do Amazonas ManausAM Brazil Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Manaus, AM, Brazil.
authors.forename: Emerson Silva
authors.initials: ES
authors.lastname: Lima
authors.affiliation: Coordenação de Biodiversidade em Saúde Centro de Pesquisa Leônidas e Maria Deane Fundação Oswaldo Cruz ManausAM Brazil Coordenação de Biodiversidade em Saúde, Centro de Pesquisa Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brazil.
authors.forename: Ivanildes
authors.initials: I
authors.lastname: dos Santos
authors.affiliation: Coordenação de Biodiversidade em Saúde Centro de Pesquisa Leônidas e Maria Deane Fundação Oswaldo Cruz ManausAM Brazil Coordenação de Biodiversidade em Saúde, Centro de Pesquisa Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brazil.
authors.forename: Patrícia Puccinelli
authors.initials: PP
authors.lastname: Orlandi
authors.affiliation: Departamento de Engenharia Química Universidade Tecnológica Federal do Paraná Ponta GrossaPR Brazil Departamento de Engenharia Química, Universidade Tecnológica Federal do Paraná, Ponta Grossa, PR, Brazil.
authors.forename: Luciano
authors.initials: L
authors.lastname: Fernandes
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013861:Thiocyanates / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D000890:Anti-Infective Agents; D013861:Thiocyanates
keywords: MRSA; Morita-Baylis-Hillman reaction; allylic thiocyanate; antimicrobial