title: Use of psychotropic drugs and associated dental diseases.
abstract: Patients with problems related to central nervous system dysfunctions are often treated with psychotropic drugs. These include antipsychotics, antidepressants, mood stabilizers, anticonvulsants, and drugs blocking specific receptors in the brain such as anticholinergics or beta-blockers. However, these medications have serious side effects affecting the oral health. In addition, many dental patients make use of psychoactive drugs, such as amphetamine, ecstasy, and cocaine. This article aims to review data on the psychotropic drugs being used in the last 30 years, their pharmacological profile, with special attention to the side effects related to the oral health. Oral diseases such as bruxism, orofacial dystonia, oromandibular dyskinesia, and rabbit syndrome are related to extrapyramidal effects of antipsychotic drugs because of their antagonist activity on the dopaminergic receptors. Drugs with anticholinergic and/or antiadrenergic effects such as tricyclic antidepressants may cause dry mouth and related complications such as candidiasis and other oral infections. Among mood stabilizers, lithium treatment induces a wide range of side effects on oral system including dry mouth, sialorrhea, infections, and ulceration of the oral cavity. Psychostimulants may instead provoke xerotomia, gingival enlargements, bruxism, dental erosion, mucosal ulceration, and oral/nasal lesions. This literature review supports the idea that the higher prevalence of oral diseases among patients with mental disorders may be attributed to the side effects of their medications mediated by complex interactions between different targeted receptors. Thus, dentists must be aware of the possible risks of these medications in order to take appropriate precautions in treating these patients.
authors.affiliation: "Sapienza" University, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fratto
authors.affiliation: "Sapienza" University, Rome, Italy.
authors.forename: Licia
authors.initials: L
authors.lastname: Manzon
mesh_terms: D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000453:epidemiology; D009059:Mouth Diseases / Q000139:chemically induced* / Q000453:epidemiology; D009909:Oral Health; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors; D009057:Stomatognathic Diseases / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D011619:Psychotropic Drugs
keywords: central nervous system dsyfunctions; dental diseases; psychotropic drugs