title: Serum insulin-like growth factor-1 and C-reactive protein concentrations before and after ovariohysterectomy in bitches with pyometra.
abstract: Pyometra is one of the most common diseases of the reproductive system in bitches. The inflammatory processes occurring in the uterus result in changes in concentrations of numerous serum biomarkers, which are used for monitoring the postoperative period. The aim of the present report was to study the evolution of serum levels of insulin-like growth factor-1 (IGF-1) and C-reactive protein (CRP) in bitches suffered from pyometra and after ovariohysterectomy in comparison with the control group of healthy dogs submitted to the surgery. Our results indicate that the serum level of IGF-1 is decreased (101.6 ng/mL [73.8-177.8 ng/mL]), whereas CRP is increased (114.6 μg/mL [95.3-131.6 μg/mL]) during severe inflammation. When inflammation caused by pyometra and surgery is resolved, the level of IGF-1 is increased (186.0 ng/mL [94.6-344.3 ng/mL], P < 0.05) and CRP decreased (23.3 μg/mL [9.9-77.0 μg/mL], P < 0.01), suggesting that these markers could be useful for assessment of the postoperative period in bitches.
authors.affiliation: Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland. Electronic address: roman.dabrowski@up.lublin.pl.
authors.forename: Roman
authors.initials: R
authors.lastname: Dąbrowski
authors.affiliation: Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Szczubiał
authors.affiliation: Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kostro
authors.affiliation: Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.
authors.forename: Władysław
authors.initials: W
authors.lastname: Wawron
authors.affiliation: Interdisciplinary Laboratory of Clinical Pathology, Iterlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, Murcia, Spain.
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Ceron
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000601:surgery*; D004285:Dogs; D005260:Female; D005786:Gene Expression Regulation; D007044:Hysterectomy / Q000662:veterinary*; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D010052:Ovariectomy / Q000662:veterinary*; D055112:Pyometra / Q000097:blood / Q000601:surgery / Q000662:veterinary*
chemical_list: D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein
keywords: Bitches; C-reactive protein; Insulin-like growth factor-1; Postoperative monitoring; Pyometra