title: Recovery of hibernating myocardium: what is the role of surgical revascularization?
abstract: Myocardial responses to chronic ischemia represent a continuum of adaptations resulting, over time, in a stress-resistant phenotype. One such adaptation, hibernating myocardium (HM), has increased antioxidant capacity that protects against ischemia-induced oxidative stress. Studies have suggested that revascularization alone may not fully restore cardiac function, highlighting the need for targeted therapies to serve as adjuncts to the innate healing process following revascularization. In our review, we discuss current understanding of HM and the recovery process following surgical revascularization, focusing on animal models of HM to understand implications for human patients.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Holley
authors.forename: Eric K
authors.initials: EK
authors.lastname: Long
authors.forename: Megan E
authors.initials: ME
authors.lastname: Lindsey
authors.forename: Edward O
authors.initials: EO
authors.lastname: McFalls
authors.forename: Rosemary F
authors.initials: RF
authors.lastname: Kelly
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism; D009204:Myocardial Revascularization; D017682:Myocardial Stunning / Q000209:etiology / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D018384:Oxidative Stress