title: Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies.
abstract: OBJECTIVE
  The findings from epidemiologic studies of dyslipidemia and colorectal cancer risk have been conflicting. We performed a dose-response meta-analysis of published prospective studies to assess the aforementioned association.
  
  
  METHODS
  Relevant studies that reported the association between the components of dyslipidemia (serum triglyceride, total cholesterol, and high-/low-density lipoprotein cholesterol) and colorectal cancer risk were identified by searching PubMed until the end of May 2014. We pooled the relative risks (RRs) from individual studies using a random- and fixed-effects models and performed dose-response, heterogeneity, and publication bias analyses.
  
  
  RESULTS
  Seventeen prospective studies, including 1,987,753 individuals with 10,876 colorectal cancer events, were included in the meta-analysis. The overall pooled RR for high versus low concentrations for triglyceride (n = 9 studies) was 1.18 (95 % CI 1.04-1.34; I (2) = 47.8 %), for total cholesterol (n = 10 studies) was 1.11 (95 % CI 1.01-1.21; I (2) = 46.7 %), for high-density lipoprotein cholesterol (n = 6 studies) was 0.84 (95 % CI 0.69-1.02; I (2) = 42.5 %), and for low-density lipoprotein cholesterol (n = 3 studies) was 1.04 (95 % CI 0.60-1.81; I (2) = 82.7 %). In the dose-response analysis, the overall pooled RR was 1.01 (95 % CI 1.00-1.03; I (2) = 0 %) per 50 mg/dL of triglyceride and 1.01 (95 % CI 0.97-1.05; I (2) = 64.3 %) per 100 mg/dL of total cholesterol.
  
  
  CONCLUSIONS
  This meta-analysis of prospective studies suggests that dyslipidemia, especially high levels of serum triglyceride and total cholesterol, is associated with an increased risk of colorectal cancer, whereas high-density lipoprotein cholesterol might associate with a decreased risk of colorectal cancer. Further studies are warranted to determine whether altering the concentrations of these metabolic variables may reduce colorectal cancer risk.
authors.affiliation: Department of General Surgery, Shengjing Hospital of China Medical University, 36, San Hao Street, Shenyang, Liaoning, 110004, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of General Surgery, Shengjing Hospital of China Medical University, 36, San Hao Street, Shenyang, Liaoning, 110004, People's Republic of China. zhongt_sjhospital@126.com.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000150:complications*; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012306:Risk; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol