title: Selective autophagy: xenophagy.
abstract: Xenophagy is an autophagic phenomenon that specifically involves pathogens and other non-host entities. Although the understanding of the relationship between autophagosomes and invading organisms has grown significantly in the past decade, the exact steps to confirm xenophagy has been not been thoroughly defined. Here we describe a methodical approach to confirming autophagy, its interaction with bacterial invasion, as well as the specific type of autophagic formation (i.e. autophagosome, autolysosome, phagolysosome). Further, we argue that xenophagy is not limited to pathogen interaction with autophagosome, but also non-microbial entities such as iron.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Bauckman
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Nana
authors.initials: N
authors.lastname: Owusu-Boaitey
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: indira@wustl.edu.
authors.forename: Indira U
authors.initials: IU
authors.lastname: Mysorekar
mesh_terms: D001343:Autophagy / Q000235:genetics*; D002002:Brucella / Q000235:genetics / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D007239:Infections / Q000235:genetics* / Q000382:microbiology; D008247:Lysosomes / Q000378:metabolism; D008967:Molecular Biology / Q000379:methods*; D010588:Phagosomes / Q000235:genetics / Q000382:microbiology / Q000473:pathology
keywords: Ferritinophagy; Infection; Inflammasome; LC3 Associated Phagocytosis; Symbiophagy; UPEC