title: MicroRNA signatures highlight new breast cancer subtypes.
abstract: MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development. Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim.
authors.affiliation: Department of Information Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India. Electronic address: malaybhattacharyya@it.iiests.ac.in.
authors.forename: Malay
authors.initials: M
authors.lastname: Bhattacharyya
authors.affiliation: Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700108, India. Electronic address: joyshreenath@gmail.com.
authors.forename: Joyshree
authors.initials: J
authors.lastname: Nath
authors.affiliation: Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700108, India. Electronic address: sanghami@isical.ac.in.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Bandyopadhyay
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D035683:MicroRNAs
keywords: Breast cancer; Cancer subtype; MicroRNA; Survival analysis