title: TDS exposure project: application of the analytic hierarchy process for the prioritization of substances to be analyzed in a total diet study.
abstract: The objective of this article is to develop a general method based on the analytic hierarchy process (AHP) methodology to rank the substances to be studied in a Total Diet Studies (TDS). This method was tested for different substances and groups of substances (N = 113), for which the TDS approach has been considered relevant. This work was performed by a group of 7 experts from different European countries representing their institutes, which are involved in the TDS EXPOSURE project. The AHP methodology is based on a score system taking into account experts' judgments quantified assigning comparative scores to the different identified issues. Hence, the 10 substances of highest interest in the framework of a TDS are trace elements (methylmercury, cadmium, inorganic arsenic, lead, aluminum, inorganic mercury), dioxins, furans and polychlorinated biphenyls (PCBs), and some additives (sulfites and nitrites). The priority list depends on both the national situation (geographical variations, consumer concern, etc.) and the availability of data. Thus, the list depends on the objectives of the TDS and on reachable analytical performances. Moreover, such a list is highly variable with time and new data (e.g. social context, vulnerable population groups, emerging substances, new toxicological data or health-based guidance values).
authors.affiliation: French Agency for Food, Environmental and Occupational Health Safety (ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail), 14, rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France. Electronic address: alexandra.papadopoulos@anses.fr.
authors.forename: A
authors.initials: A
authors.lastname: Papadopoulos
authors.affiliation: Department of Public Health, Universiteit Gent - Ghent University, UZ 2 Block A, De Pintelaan 185, B-9000 Gent, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Sioen
authors.affiliation: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità - National Health Institute, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cubadda
authors.affiliation: TÜBİTAK Marmara Research Center, Food Institute, P.O. Box 21, 41470 Kocaeli, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Ozer
authors.affiliation: TÜBİTAK Marmara Research Center, Food Institute, P.O. Box 21, 41470 Kocaeli, Turkey.
authors.forename: H I Oktay
authors.initials: HI
authors.lastname: Basegmez
authors.affiliation: Consiglio per la Ricerca e la sperimentazione in Agricoltura (CRA) - Centro di Ricerca per gli alimenti e la NUTrizione (CRA-NUT), Via Ardeatina 546, I-00178 Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Turrini
authors.affiliation: Agencia Española de Seguridad Alimentaria y Nutrición, C/Alcalá, 56 28071 Madrid, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Lopez Esteban
authors.affiliation: Agencia Española de Seguridad Alimentaria y Nutrición, C/Alcalá, 56 28071 Madrid, Spain.
authors.forename: P M
authors.initials: PM
authors.lastname: Fernandez San Juan
authors.affiliation: Hrvatska agencija za hranu/Croatian Food Agency, Ivana Gundulića 36b, 31000 Osijek, Hrvatska, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Sokolić-Mihalak
authors.affiliation: Hrvatska agencija za hranu/Croatian Food Agency, Ivana Gundulića 36b, 31000 Osijek, Hrvatska, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Jurkovic
authors.affiliation: Department of Public Health, Universiteit Gent - Ghent University, UZ 2 Block A, De Pintelaan 185, B-9000 Gent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: De Henauw
authors.affiliation: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità - National Health Institute, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Aureli
authors.affiliation: French Agency for Food, Environmental and Occupational Health Safety (ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail), 14, rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
authors.forename: K
authors.initials: K
authors.lastname: Vin
authors.affiliation: French Agency for Food, Environmental and Occupational Health Safety (ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail), 14, rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Sirot
mesh_terms: D000348:Aflatoxins / Q000032:analysis; D001151:Arsenic / Q000032:analysis; D002104:Cadmium / Q000032:analysis; D004032:Diet; D004147:Dioxins / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis*; D005060:Europe; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis; D008628:Mercury / Q000032:analysis; D019216:Metals, Heavy / Q000032:analysis; D009573:Nitrites / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis; D018570:Risk Assessment; D013447:Sulfites / Q000032:analysis
chemical_list: D000348:Aflatoxins; D004147:Dioxins; D019216:Metals, Heavy; D009573:Nitrites; D013447:Sulfites; D002104:Cadmium; D011078:Polychlorinated Biphenyls; D008628:Mercury; D001151:Arsenic
keywords: Analytic hierarchy process; Expert judgment; Prioritization; Substance; Total diet study