title: Comparative hair restorer efficacy of medicinal herb on nude (Foxn1nu) mice.
abstract: Eclipta alba (L.) Hassk, Asiasarum sieboldii (Miq.) F. Maek (Asiasari radix), and Panax ginseng C. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations. The hair density and length of Eclipta alba treated mice were increased significantly (P>0.001) than control mice. Hair growth area was also distinctly visible in Eclipta alba treated mice. On the other hand, Asiasari radix and Panax ginseng treated mice developing hair loss were recognized from the abortive boundaries of hair coverage. Histomorphometric observation of nude mice skin samples revealed an increase in number of hair follicles (HFs). The presence of follicular keratinocytes was confirmed by BrdU labeling, S-phase cells in HFs. Therefore, Eclipta alba extract and/or phytochemicals strongly displayed incomparability of hair growth promotion activity than others. Thus, the standardized Eclipta alba extract can be used as an effective, alternative, and complementary treatment against hair loss.
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Begum
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Mi Ra
authors.initials: MR
authors.lastname: Lee
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Li Juan
authors.initials: LJ
authors.lastname: Gu
authors.affiliation: Molecular Genetics and Genomics Lab, Department of Horticulture, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Md Jamil
authors.initials: MJ
authors.lastname: Hossain
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Hyun Kyoung
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Chang Keun
authors.initials: CK
authors.lastname: Sung
mesh_terms: D000818:Animals; D004357:Drug Synergism; D006197:Hair / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D010936:Plant Extracts