title: Widespread of ESBL- and carbapenemase GES-type genes on carbapenem-resistant Pseudomonas aeruginosa clinical isolates: a multicenter study in Mexican hospitals.
abstract: The present work describes a prevalence of 36.2% of carbapenemases IMP-, VIM-, and GES-type on 124 imipenem-resistant Pseudomonas aeruginosa clinical isolates. The ESBL GES-19 and carbapenemase GES-20 genes were the most prevalent (84.4%) β-lactamases among imipenem-resistant P. aeruginosa clinical isolates in Mexico. These genes are chromosomal encoded on embedded class 1 integron arrays.
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico.
authors.forename: Ulises
authors.initials: U
authors.lastname: Garza-Ramos
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico.
authors.forename: Humberto
authors.initials: H
authors.lastname: Barrios
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyna-Flores
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico.
authors.forename: Elsa
authors.initials: E
authors.lastname: Tamayo-Legorreta
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Catalan-Najera
authors.affiliation: Hospital Civil de Guadalajara (HCG-J) Fray Antonio Alcalde, Instituto de Patología, CUCS, UDG Guadalajara, Jalisco, Mexico.
authors.forename: Rayo
authors.initials: R
authors.lastname: Morfin-Otero
authors.affiliation: Hospital Civil de Guadalajara (HCG-J) Fray Antonio Alcalde, Instituto de Patología, CUCS, UDG Guadalajara, Jalisco, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodríguez-Noriega
authors.affiliation: Instituto Nacional de Cancerología (INCan), Ciudad de México, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Volkow
authors.affiliation: Instituto Nacional de Cancerología (INCan), Ciudad de México, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Cornejo-Juarez
authors.affiliation: Centro Médico Nacional Siglo XXI-Cardiología (CMNSXXI), Ciudad de México, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: González
authors.affiliation: Hospital de Infectología del Centro médico Nacional La Raza (HICMNR), Ciudad de México, Mexico.
authors.forename: Jesus
authors.initials: J
authors.lastname: Gaytan-Martinez
authors.affiliation: Unidad Médica de Alta Especialidad No. 71 IMSS, Torreon, Coahuila, Mexico.
authors.forename: Marisela
authors.initials: M
authors.lastname: Del Rocío Gónzalez-Martínez
authors.affiliation: Unidad Médica de Alta Especialidad No. 71 IMSS, Torreon, Coahuila, Mexico.
authors.forename: Maria
authors.initials: M
authors.lastname: Vazquez-Farias
authors.affiliation: Instituto Nacional de Salud Pública (INSP), CISEI, Cuernavaca, Morelos, Mexico. Electronic address: jsilva@insp.mx.
authors.forename: Jesus
authors.initials: J
authors.lastname: Silva-Sanchez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D002876:Chromosomes, Bacterial; D005798:Genes, Bacterial; D006761:Hospitals; D032023:Integrons; D008800:Mexico; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases
keywords: ESBL; GES; IMP; Imipenem resistance; VIM