title: Evaluation of corneal deformation analyzed with a Scheimpflug based device.
abstract: OBJECTIVE
  To evaluate the correlation between corneal biomechanical and morphological data in healthy eyes.
  
  
  METHODS
  A complete clinical eye examination of naïve eyes was followed by tomographic (Pentacam, Oculus, Wetzlar, Germany) and biomechanical (Corvis ST, Oculus, Wetzlar, Germany) evaluation. Linear regression between central corneal thickness (CCT), corneal volume (CV) and anterior corneal curvature measured with Sim'K (SK), versus corneal deformation parameters measured with Corvis ST have been run using SPSS software version 18.0.
  
  
  RESULTS
  Seventy-six eyes of 76 healthy subjects (44 women and 32 men) with a mean age of 36.84 ± 10.74 years and a mean refractive error of -0.55 ± 1.68 D (measured as spherical equivalent) were evaluated. Corneal deformation parameters were weakly correlated with corneal morphological parameters and with spherical equivalent. Although the correlations between deformation amplitude versus SK and between SK versus Velocity of Applanation 2, were higher than the others (R(2) = 0.28 and 0.26 respectively), none of them was statistically significant (p>0.01).
  
  
  CONCLUSIONS
  According with these findings, Corvis ST seems to be able to provide an analysis of corneal deformation independent from corneal morphological characteristics. If these data will be confirmed in further studies, this device could be useful in the management and screening of eyes with corneal diseases.
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy; Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy. Electronic address: mic.lanza@gmail.com.
authors.forename: Michele
authors.initials: M
authors.lastname: Lanza
authors.affiliation: Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Cennamo
authors.affiliation: Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Iaccarino
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Romano
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Bifani
authors.affiliation: Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Irregolare
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lanza
mesh_terms: D000328:Adult; D000368:Aged; D001699:Biometry / Q000295:instrumentation*; D003315:Cornea / Q000033:anatomy & histology* / Q000502:physiology*; D063171:Corneal Pachymetry / Q000295:instrumentation*; D019781:Corneal Topography / Q000295:instrumentation*; D055119:Elastic Modulus / Q000502:physiology; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D055815:Young Adult
keywords: Biomechanical evaluation; Corneal biomechanics; Corneal pachimetry; Naive eyes; Tomographic evaluation