title: Epigenetic noise fuels cancer evolution.
abstract: Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.
authors.affiliation: Cancer Research UK London Research Institute, London WC2A 3LY, UK; UCL Cancer Institute, London WC1E 6BT, UK. Electronic address: charles.swanton@cancer.org.uk.
authors.forename: Charles
authors.initials: C
authors.lastname: Swanton
authors.affiliation: UCL Cancer Institute, London WC1E 6BT, UK. Electronic address: s.beck@ucl.ac.uk.
authors.forename: Stephan
authors.initials: S
authors.lastname: Beck
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*