title: Physical exercise and weight loss for hip and knee osteoarthritis in very old patients: a systematic review of the literature.
abstract: BACKGROUND
  Rheumatologic and geriatric scholarly organisations recommendations for the management of hip and knee osteoarthritis, which emphasise the usefulness of non-pharmacological therapies, are not scaled according to patient's age and physical condition. We conducted a systematic review of clinical trials on exercise and weight loss in hip and knee osteoarthritis in very old patients.
  
  
  METHODS
  Electronic search in MEDLINE, EMBASE, PASCAL database, systematic search of the Cochrane Reviews, manual search in guidelines, meta-analyses and identified relevant articles.
  
  
  RESULTS
  We identified 83 trials, with only 2 on patients aged ≥ 75 years; we therefore lowered the mean age threshold to 70 years and found 15 trials, mainly performed in knee osteoarthritis and outpatients.
  was effective on pain and function (4 controlled trials), with a persistent effect only in case of self-rehabilitation.
  was as effective as land-based exercise.
  only patients under diet + exercise had significant improvement on symptoms.
  
  
  CONCLUSIONS
  Our systematic review confirms that international recommendations on exercise for knee osteoarthritis also apply to subjects aged 70-80 years. Long-term effectiveness requires a maintenance strategy. Specific trials on very old patients with various comorbidities are mandatory, given that these subjects are more exposed to drug-related iatrogenesis.
authors.affiliation: Service de Médecine Gériatrique 3 [Department of Geriatric Medicine 3], Hôpital Sainte-Périne (A.P-H.P), Paris, France.
authors.forename: Jean-Laurent Le
authors.initials: JL
authors.lastname: Quintrec
authors.affiliation: Pôle Vieillissement, réadaptation et Accompagnement [Centre for the Aged, Rehabilitation and Support], Hôpital Paul Brousse (A.P-H.P) Villejuif, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Verlhac
authors.affiliation: Medical Office, Paris, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Cadet
authors.affiliation: Service de Rhumatologie [Department of Rheumatology], Groupe Hospitalier Paris Saint Joseph, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bréville
authors.affiliation: Centre Hospitalier, Le Mans, France.
authors.forename: Jean M
authors.initials: JM
authors.lastname: Vetel
authors.affiliation: Centre de Médecine Interne Gériatrique [Centre for Geriatric Internal Medicine], Centre Hospitalier régional, Orléans, France.
authors.forename: Jean B
authors.initials: JB
authors.lastname: Gauvain
authors.affiliation: Service de Médecine interne et Gériatrie [Department of Internal and Geriatric Medicine], Montpellier, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Jeandel
authors.affiliation: Service de Rhumatologie, Rheumatology Department, Medical Office / Hôpital Saint Antoine -A.P-H.P, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Maheu
keywords: Hip osteoarthritis; knee; physical exercise; systematic review; very old; weight loss.