title: Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors.
abstract: OBJECTIVE
  A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized.
  
  
  METHODS
  It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels.
  
  
  RESULTS
  The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo.
  
  
  CONCLUSIONS
  The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors.forename: Hua-Jing
authors.initials: HJ
authors.lastname: Jhan
authors.forename: Jun-Jen
authors.initials: JJ
authors.lastname: Liu
authors.forename: Ying-Chen
authors.initials: YC
authors.lastname: Chen
authors.forename: Der-Zen
authors.initials: DZ
authors.lastname: Liu
authors.forename: Ming-Thau
authors.initials: MT
authors.lastname: Sheu
authors.forename: Hsiu-O
authors.initials: HO
authors.lastname: Ho
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007267:Injections; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D044367:Phase Transition; D020442:Poloxamer / Q000737:chemistry*; D013696:Temperature
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D020100:Hydrogels; D020442:Poloxamer; D004317:Doxorubicin; D006820:Hyaluronic Acid
keywords: Pluronic F127; doxorubicin; hyaluronic acid; hydrogel; intratumoral