title: Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells.
abstract: The combination of imaging diagnosis and photothermal ablation (PTA) therapy has become a potential treatment for cancer. In particular, tungsten bronzes have a number of unique properties such as broad near-infrared (NIR) absorption and a large X-ray attenuation coefficient. However, these materials have seldom been reported as an X-ray computed tomography (CT) contrast agent and a photothermal agent. Herein, we synthesized PEGylated Na(0.3)WO(3) nanorods (mean size ∼39 nm × 5 nm) by a simple one-pot solvothermal route. As we expected, the prepared PEGylated Na(0.3)WO(3) nanorods exhibit intense NIR absorption, derived from the outer d-electron of W(5+). These PEGylated Na(0.3)WO(3) nanorods also show an excellent CT imaging effect and a high HU value of 29.95 HU g L(-1) (much higher than the figure of iopamidol (19.35 HU g L(-1))), due to the intrinsic property of tungsten of large atomic number and X-ray attenuation coefficient. Furthermore, the temperature elevation and the in vivo photothermal experiment reveal that as-synthesized Na(0.3)WO(3) nanorods could be an effective photothermal agent, as they have low toxicity, high effectiveness and good photostability.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yunjiu
authors.initials: Y
authors.lastname: Cao
authors.forename: Jinbao
authors.initials: J
authors.lastname: Qin
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Peng
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Xiao
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.forename: Rujia
authors.initials: R
authors.lastname: Zou
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D043942:Nanotubes / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D010087:Oxides / Q000737:chemistry; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D013329:Structure-Activity Relationship; D014414:Tungsten / Q000737:chemistry; D055114:X-Ray Microtomography
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010087:Oxides; D011092:Polyethylene Glycols; C511604:tungsten oxide; D012964:Sodium; D014414:Tungsten