title: Personalised dosing: Printing a dose of one's own medicine.
abstract: Ink-jet printing is a versatile, precise and relatively inexpensive method of depositing small volumes of solutions with remarkable accuracy and repeatability. Although developed primarily as a technology for image reproduction, its areas of application have expanded significantly in recent years. It is particularly suited to the manufacture of low dose medicines or to short production runs and so offers a potential manufacturing solution for the paradigm of personalised medicines. This review discusses the technical and clinical aspects of ink-jet printing that must be considered in order for the technology to become widely adopted in the pharmaceutical arena and considers applications in the literature.
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1 N 1AX, UK.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Alomari
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1 N 1AX, UK.
authors.forename: Fatima H
authors.initials: FH
authors.lastname: Mohamed
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1 N 1AX, UK.
authors.forename: Abdul W
authors.initials: AW
authors.lastname: Basit
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1 N 1AX, UK. Electronic address: s.gaisford@ucl.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Gaisford
mesh_terms: D003199:Computer Systems; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000191:economics / Q000295:instrumentation*; D004355:Drug Stability; D019220:High-Energy Shock Waves; D006801:Humans; D057285:Precision Medicine / Q000191:economics / Q000295:instrumentation*; D013678:Technology, Pharmaceutical / Q000191:economics / Q000295:instrumentation*; D013997:Time Factors
keywords: Ink-jet printing; Narrow therapeutic index; Personalised medicine; Pharmaceutical; Piezoelectric printer