title: Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.
abstract: Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Amandine
authors.initials: A
authors.lastname: Chaix
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Gastroenterology, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Zarrinpar
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Phuong
authors.initials: P
authors.lastname: Miu
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: satchin@salk.edu.
authors.forename: Satchidananda
authors.initials: S
authors.lastname: Panda
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D004041:Dietary Fats / Q000009:adverse effects; D002149:Energy Intake / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D008659:Metabolic Diseases / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000517:prevention & control; D013997:Time Factors; D015430:Weight Gain / Q000502:physiology
chemical_list: D004041:Dietary Fats