title: The effects of intraoperative dexamethasone on left atrial function and postoperative atrial fibrillation in cardiac surgical patients.
abstract: Postoperative new-onset atrial fibrillation (PNAF) is very common after cardiac surgery and postoperative inflammation may contribute to PNAF by inducing atrial dysfunction. Corticosteroids reduce inflammation and may thus reduce atrial dysfunction and PNAF development. This study aimed to determine whether dexamethasone protects against left atrial dysfunction and PNAF in cardiac surgical patients. Cardiac surgical patients were randomised to a single dose of dexamethasone (1 mg.kg(-1)) or placebo after inducing anaesthesia. Transoesophageal echocardiography was performed in patients before and after surgery. Primary outcome was left atrial total ejection fraction (LA-TEF) after sternal closure; secondary outcomes included left atrial diameter and PNAF. 62 patients were included. Baseline characteristics were well balanced. Postoperative LA-TEF was 36.4 % in the dexamethasone group and 40.2 % in the placebo group (difference -3.8 %; 95 % confidence interval (CI) -9.0 to 1.4 %; P = 0.15). Postoperative left atrial diameter was 4.6 and 4.3 cm, respectively (difference 0.3; 95 % CI -0.2 to 0.7; P = 0.19). The incidence of PNAF was 30 % in the dexamethasone group and 39 % in the placebo group (P = 0.47). Intraoperative high-dose dexamethasone did not protect against postoperative left atrial dysfunction and did not reduce the risk of PNAF in cardiac surgical patients.
authors.affiliation: Department of Anesthesiology and Intensive Care, University Medical Center Utrecht, Mail Stop F.06.149, PO Box 85500, 3508, Utrecht, the Netherlands, k.a.jacob@umcutrecht.nl.
authors.forename: K A
authors.initials: KA
authors.lastname: Jacob
authors.forename: J M
authors.initials: JM
authors.lastname: Dieleman
authors.forename: H M
authors.initials: HM
authors.lastname: Nathoe
authors.forename: D
authors.initials: D
authors.lastname: van Osch
authors.forename: E E C
authors.initials: EE
authors.lastname: de Waal
authors.forename: M J
authors.initials: MJ
authors.lastname: Cramer
authors.forename: J
authors.initials: J
authors.lastname: Kluin
authors.forename: D
authors.initials: D
authors.lastname: van Dijk