title: Trophoblastic E-cadherin and TGF-beta expression in placenta percreta and normal pregnancies.
abstract: OBJECTIVE
  This study aimed to evaluate whether trophoblastic transforming growth factor beta (TGF-β) and E-cadherin expression levels have a role in placenta percreta (PP) aetiopathogenesis.
  
  
  METHODS
  This study was carried out in the Obstetrics & Gynecology and Pathology Departments of Harran University Medicine School. Forty-four women who underwent caesarean section for PP and other obstetric reasons were included in this study. PP was defined as the detection of placental invasion during the histopathological examination of the hysterectomy specimen, which passes the uterine wall as a whole layer and involves the uterine serosa. Placental tissue samples were collected from all pregnant patients to evaluate TGF-β and E-cadherin expression levels.
  
  
  RESULTS
  No significant difference was found in demographic features, including age, gestational week, number of pregnancies and body mass index, among the groups. Immunohistochemical staining against E-cadherin, a cell adhesion molecule, showed significantly reduced staining in PP patients (p = 0.048). TGF-β staining was also low in PP patients, but this difference was not significant (p = 0.107).
  
  
  CONCLUSIONS
  The findings of this study suggest that a decrease in trophoblastic E-cadherin expression may have an important role in PP aetiopathogenesis.
authors.affiliation: a Department of Gynecology and Obstetrics , and.
authors.forename: Adnan
authors.initials: A
authors.lastname: Incebiyik
authors.affiliation: b Department of Pathology, Faculty of Medicine , Harran University , Sanliurfa , Turkey , and.
authors.forename: Sezen
authors.initials: S
authors.lastname: Kocarslan
authors.affiliation: a Department of Gynecology and Obstetrics , and.
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoglu
authors.affiliation: a Department of Gynecology and Obstetrics , and.
authors.forename: Nese Gul
authors.initials: NG
authors.lastname: Hilali
authors.affiliation: c Department of Internal Medicine , Sanliurfa Edessa Hospital , Sanliurfa , Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Incebiyik
authors.affiliation: a Department of Gynecology and Obstetrics , and.
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
mesh_terms: D000328:Adult; D015820:Cadherins / Q000378:metabolism*; D005260:Female; D006801:Humans; D010921:Placenta Accreta / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015820:Cadherins; D016212:Transforming Growth Factor beta
keywords: E-cadherin; TGF-β; placenta percreta; trophoblastic invasion