title: Bronchogenic squamous cell carcinoma with soft-tissue metastasis to the hand: an unusual case presentation and review of the literature.
abstract: Carcinoma of the lung is the most common lethal form of cancer in both men and women worldwide. Orthopedic manifestations of lung cancer frequently include bony metastasis, most commonly the vertebrae (42%), ribs (20%), and pelvis (18%). Acral metastatic disease is defined as metastasis distal to the elbow or the knee. Metastases to the bones of the hand are extremely rare. Only 0.1% of metastatic disease resulting from any type of carcinoma or sarcoma manifests as metastasis in the hand. There are only a few reports in the literature of soft-tissue or muscular metastasis to the hand from a carcinoma. Of these cases, the majority are caused by metastatic lung carcinoma. However, there are no reports in the literature of metastatic disease of squamous cell origin affecting the soft tissues of the hand. We present a case of a man with known metastatic squamous cell carcinoma of the lung who presented with acral soft-tissue metastatic disease. This report highlights a rare clinical scenario that has not been reported in the literature. This report also highlights a rare but important consideration for clinicians who encounter acral soft-tissue lesions in patients with a history of a primary carcinoma.
authors.forename: Zeke J
authors.initials: ZJ
authors.lastname: Walton
authors.affiliation: Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston, SC. holmesre@musc.edu.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Holmes
authors.forename: Russell W
authors.initials: RW
authors.lastname: Chapin
authors.forename: Kathryn G
authors.initials: KG
authors.lastname: Lindsey
authors.forename: Lee R
authors.initials: LR
authors.lastname: Leddy
mesh_terms: D002283:Carcinoma, Bronchogenic / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D006225:Hand; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000556:secondary*