title: Polymorphic expression of CYP2C19 and CYP2D6 in the developing and adult human brain causing variability in cognition, risk for depression and suicide: the search for the endogenous substrates.
authors.affiliation: Department of Physiology & Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Ingelman-Sundberg
authors.forename: Anna
authors.initials: A
authors.lastname: Persson
authors.forename: Marin M
authors.initials: MM
authors.lastname: Jukic
mesh_terms: D001921:Brain / Q000254:growth & development* / Q000503:physiopathology; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology; D065731:Cytochrome P-450 CYP2C19 / Q000096:biosynthesis / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000096:biosynthesis / Q000235:genetics*; D003863:Depression / Q000235:genetics / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D013405:Suicide
chemical_list: C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6
keywords: GABA receptors; depression; endocannabinoids; gene duplication; serotonin; ultrarapid metabolizer