title: The developmental effects of extremely low frequency electric fields on visual and somatosensory evoked potentials in adult rats.
abstract: The purpose of our study was to investigate the developmental effects of extremely low frequency electric fields (ELF-EFs) on visual evoked potentials (VEPs) and somatosensory-evoked potentials (SEPs) and to examine the relationship between lipid peroxidation and changes of these potentials. In this context, thiobarbituric acid reactive substances (TBARS) levels were determined as an indicator of lipid peroxidation. Wistar albino female rats were divided into four groups; Control (C), gestational (prenatal) exposure (Pr), gestational+ postnatal exposure (PP) and postnatal exposure (Po) groups. Pregnant rats of Pr and PP groups were exposed to 50 Hz electric field (EF) (12 kV/m; 1 h/day), while those of C and Po groups were placed in an inactive system during pregnancy. Following parturition, rats of PP and Po groups were exposed to ELF-EFs whereas rats of C and Pr groups were kept under the same experimental conditions without being exposed to any EF during 68 days. On postnatal day 90, rats were prepared for VEP and SEP recordings. The latencies of VEP components in all experimental groups were significantly prolonged versus C group. For SEPs, all components of PP group, P2, N2 components of Pr group and P1, P2, N2 components of Po group were delayed versus C group. As brain TBARS levels were significantly increased in Pr and Po groups, retina TBARS levels were significantly elevated in all experimental groups versus C group. In conclusion, alterations seen in evoked potentials, at least partly, could be explained by lipid peroxidation in the retina and brain.
authors.affiliation: a Department of Biophysics , Faculty of Medicine, Akdeniz University , Antalya , Turkey .
authors.forename: Deniz Kantar
authors.initials: DK
authors.lastname: Gok
authors.affiliation: a Department of Biophysics , Faculty of Medicine, Akdeniz University , Antalya , Turkey .
authors.forename: Deniz
authors.initials: D
authors.lastname: Akpinar
authors.affiliation: a Department of Biophysics , Faculty of Medicine, Akdeniz University , Antalya , Turkey .
authors.forename: Enis
authors.initials: E
authors.lastname: Hidisoglu
authors.affiliation: b Department of Electrical and Electronics Engineering , Engineering Faculty, Akdeniz University , Antalya , Turkey , and.
authors.forename: Sukru
authors.initials: S
authors.lastname: Ozen
authors.affiliation: c Department of Physiology , Faculty of Medicine, Akdeniz University , Antalya , Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Agar
authors.affiliation: a Department of Biophysics , Faculty of Medicine, Akdeniz University , Antalya , Turkey .
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargicoglu
mesh_terms: D000818:Animals; D004560:Electricity; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D015227:Lipid Peroxidation; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D017392:Thiobarbituric Acid Reactive Substances
keywords: Developmental period; electric field; lipid peroxidation; somatosensory evoked potentials; visual evoked potentials