title: [The role of type II collagen fragments and X-ray progression of knee osteoarthritis].
abstract: OBJECTIVE
  To investigate the association between type II collagen fragments and the presence of knee osteoarthritis (OA) in the Tunisian population and to determine whether this biomarker can predict X-ray progression of this disease.
  
  
  METHODS
  Type II collagen C-telopeptide (uCTX-II) and helical peptide (sHelix-II) were assessed in 125 female patients with knee osteoarthritis aged 54 ± 8 years over 2 years and 57 female age-matched controls. The markers were measured at baseline, 1 and 2 yrs' follow-up corresponding to x-ray time points.
  
  
  RESULTS
  Only urinary CTX-II values were significantly 48% higher in knee OA patients compared with controls (p=0.001). The longitudinal changes over 2 yrs in Helix-II were also significantly associated with Joint Space Narrowing: JSN (p=0.03). Over the 2-yr study period average CTX-II levels were not significantly higher in progressor compared with non-progressor (339.96 vs 256.00; NS).
  
  
  CONCLUSIONS
  The data presented here suggest that CTX-II may be useful to identify patients with knee OA. These results demonstrate significantly association between progression of this disease and alterations levels of Helix-II.
authors.affiliation: Service de biochimie, Clinique Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Eya
authors.initials: E
authors.lastname: Kalaï
authors.affiliation: Service de biochimie, Clinique Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Afef
authors.initials: A
authors.lastname: Bahlous
authors.affiliation: Service de biochimie, Clinique Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Kahena
authors.initials: K
authors.lastname: Bouzid
authors.affiliation: Laboratoire de recherche immuno-rhumatologie, Service de rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Lilia
authors.initials: L
authors.lastname: Laadhar
authors.affiliation: Laboratoire de recherche immuno-rhumatologie, Service de rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Elhem
authors.initials: E
authors.lastname: Cheour
authors.affiliation: Laboratoire de recherche immuno-rhumatologie, Service de rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Sellami
authors.affiliation: Service de biochimie, Clinique Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Jaouida
authors.initials: J
authors.lastname: Abdelmoula
authors.affiliation: Laboratoire de recherche immuno-rhumatologie, Service de rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Hela
authors.initials: H
authors.lastname: Sahli
authors.affiliation: Laboratoire de recherche immuno-rhumatologie, Service de rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Mouna
authors.initials: M
authors.lastname: Chelly
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D024043:Collagen Type II / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D010446:Peptide Fragments / Q000097:blood / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D059748:Proteolysis; D011859:Radiography; D014416:Tunisia / Q000453:epidemiology; D014965:X-Rays
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D010446:Peptide Fragments; C543437:collagen II C-telopeptide
keywords: biochemical markers; osteoarthritis; type II collagen