title: Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiology.
abstract: Glioblastoma (GBM) is the most common and most aggressive primary malignant tumor of the central nervous system. Recently, researchers concluded that the "one-size-fits-all" approach for treatment of GBM is no longer valid and research should be directed toward more personalized and patient-tailored treatment protocols. Identification of the molecular and genomic pathways underlying GBM is essential for achieving this personalized and targeted therapeutic approach. Imaging genomics represents a new era as a noninvasive surrogate for genomic and molecular profile identification. This article discusses the basics of imaging genomics of GBM, its role in treatment decision-making, and its future potential in noninvasive genomic identification.
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA.
authors.forename: Mohamed G
authors.initials: MG
authors.lastname: ElBanan
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Amer
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Pascal O
authors.initials: PO
authors.lastname: Zinn
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA. Electronic address: rcolen@mdanderson.org.
authors.forename: Rivka R
authors.initials: RR
authors.lastname: Colen
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D005909:Glioblastoma / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods*
keywords: 1p/19q; EGFR; Genetic biomarkers; Glioblastoma; IDH1; Imaging genomics; MGMT; Radiogenomics