title: Isolation and stereospecific synthesis of janolusimide B from a New Zealand collection of the bryozoan Bugula flabellata.
abstract: NMR-directed screening of New Zealand marine organisms has led to the isolation of the modified tripeptide janolusimide B from the common invasive bryozoan Bugula flabellata. The structure was established by NMR and MS analysis, degradative hydrolysis and derivatization, and stereoselective fragment synthesis. The bryozoan natural product is an N-methyl analogue of janolusimide, previously reported from the Mediterranean nudibranch Janolus cristatus, a species known to prey upon bryozoa.
authors.affiliation: †School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Wang
authors.affiliation: ‡Chemistry, School of Science, Faculty of Science and Engineering, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
authors.forename: Michèle R
authors.initials: MR
authors.lastname: Prinsep
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Gordon
authors.affiliation: ⊥NIWA, PO Box 893, Nelson 7010, New Zealand.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Page
authors.affiliation: †School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Copp
mesh_terms: D000818:Animals; D002013:Bryozoa / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D009842:Oligopeptides; C000598679:janolusimide B