title: Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx.
abstract: OBJECTIVE
  To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx.
  
  
  METHODS
  We present a narrative literature review, conducted in PubMed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk in different populations worldwide.
  
  
  RESULTS
  We initially found 65 articles and, after selection criteria, 20 case-control studies with various populations worldwide were eligible. The most studied polymorphisms were those of CYP2E1 and CYP1A1 subfamilies. There is little about the other subfamilies. The association found between polymorphisms and cancer risk amounted to a countless number of variables, amongst them: population, selection methods, racial factors and different modes of exposure to carcinogens, genotyping methods, and nomenclature of the polymorphisms.
  
  
  CONCLUSIONS
  so far, there is no proven link between genetic polymorphisms of cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx relationship.
authors.affiliation: Department of Surgery, Faculty of Medical Sciences.
authors.forename: Celso Muller
authors.initials: CM
authors.lastname: Bandeira
authors.affiliation: Department of Surgery, Faculty of Medical Sciences.
authors.forename: Adriana Ávila de
authors.initials: AÁ
authors.lastname: Almeida
authors.affiliation: Department of Surgery, Faculty of Medical Sciences.
authors.forename: Antonio José
authors.initials: AJ
authors.lastname: Gonçalves
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D010610:Pharyngeal Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D003577:Cytochrome P-450 Enzyme System