title: The influences of hyperbaric oxygen therapy with a lower pressure and oxygen concentration than previous methods on physiological mechanisms in dogs.
abstract: Recently, hyperbaric oxygen therapy with a lower pressure and oxygen concentration (L-HBOT) than previous methods has been used for dogs in Japan; however, the influences of L-HBOT on dogs have not been clarified. To verify the influences of L-HBOT on physiological mechanism in dogs, we investigated blood gas parameters, glutathione peroxidase (GPx) activity, heart rate variability, stress-related hormones and skin conductance (SC) in 4 clinically normal beagle dogs with catheters in their carotid arteries and jugular veins when they were quiet, after running, after receiving L-HBOT (30% oxygen concentration, 1.3 atmospheres absolute, 30 min) or after not receiving L-HBOT. The results showed there were no changes in blood gas parameters, heart rate variability and catecholamine levels after L-HBOT. GPx activity was significantly higher, and the SC and cortisol level were lower in dogs that received L-HBOT than those when they were quiet. These results suggested that L-HBOT may have a small influence on oxygenation dynamics, activate antioxidant enzymes such as GPx, restrain autonomic nervous activity and control the balance between oxidation and antioxidation inside the body.
authors.affiliation: Department of Veterinary Clinical Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ohrai-kita, Izumisano, Osaka 598-8531, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Hayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyoshi
authors.forename: Fumihito
authors.initials: F
authors.lastname: Ohashi
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005979:Glutathione Peroxidase / Q000097:blood / Q000235:genetics / Q000378:metabolism; D006339:Heart Rate; D006931:Hyperbaric Oxygenation / Q000379:methods / Q000662:veterinary*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010313:Partial Pressure; D013312:Stress, Physiological
chemical_list: D005979:Glutathione Peroxidase; D010100:Oxygen