title: Pyrrole alkaloids from the fruits of Morus alba.
abstract: Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea.
authors.forename: Seon Beom
authors.initials: SB
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, Republic of Korea.
authors.forename: Bo Yoon
authors.initials: BY
authors.lastname: Chang
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, Republic of Korea. Electronic address: sungykim@wonkwang.ac.kr.
authors.forename: Sung Yeon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea. Electronic address: mklee@chungbuk.ac.kr.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D005638:Fruit / Q000737:chemistry*; D008049:Lipase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013552:Swine
chemical_list: D000470:Alkaloids; D011758:Pyrroles; D008049:Lipase; C518354:PNLIP protein, human
keywords: Moraceae; Morroles B–F; Morus alba; Mulberry; Pancreatic lipase; Pyrrole alkaloids