title: Gene expression profiling in melasma in Korean women.
abstract: BACKGROUND
  There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one.
  
  
  OBJECTIVE
  Our aim was to identify novel genes involved in the pathogenesis of melasma.
  
  
  METHODS
  We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma.
  
  
  RESULTS
  There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier.
  
  
  CONCLUSIONS
  This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.
authors.affiliation: Department of Dermatology, College of Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Chung
authors.forename: Tai Kyung
authors.initials: TK
authors.lastname: Noh
authors.forename: Sang Hwa
authors.initials: SH
authors.lastname: Yang
authors.forename: Il Hwan
authors.initials: IH
authors.lastname: Kim
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Yoon
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
mesh_terms: D000328:Adult; D004247:DNA / Q000032:analysis*; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008548:Melanosis / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D054419:Receptors, Adiponectin / Q000032:analysis; D056910:Republic of Korea; D015398:Signal Transduction / Q000235:genetics; D015854:Up-Regulation
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D047492:Peroxisome Proliferator-Activated Receptors; D054419:Receptors, Adiponectin; D004247:DNA