title: Combination of fluoroalkylation and Kornblum-DeLaMare reaction: a new strategy for the construction of (Z)-β-perfluoroalkyl enaminones.
abstract: A novel strategy has been developed for the highly chemo- and stereo-selective synthesis of (Z)-β-perfluoroalkyl enaminones from readily available starting materials via a multicomponent radical reaction involving sequential fluoroalkylation and Kornblum-DeLaMare reaction. Notably, this methodology involves the concurrent cleavage of at least three chemical bonds, including two C-F bonds and one C-X (X = Br or I) bond, as well as the formation of three new bonds, including one C=O bond, one C=C bond and one C-N bond, in one pot.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Road, 215123 Suzhou, China. wanxb@suda.edu.cn.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Liu
authors.forename: Erbo
authors.initials: E
authors.lastname: Shi
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Luo
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Wang
authors.forename: Jijun
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D054879:Halogenation; D013237:Stereoisomerism
chemical_list: D000475:Alkenes