title: Gemcitabine-based regimen for primary ovarian angiosarcoma with MYC amplification.
abstract: Angiosarcoma is a rare and aggressive type of sarcoma, and primary angiosarcoma of the ovary is extremely rare. We report the case of a 29-year-old woman who was diagnosed with ovarian angiosarcoma and possible bone metastases. We treated this patient with a gemcitabine-based regimen as postoperative adjuvant chemotherapy, after which she achieved at least 7 years of progression-free survival, an extremely long duration given the aggressive features of this tumour. We retrospectively performed immunohistochemical analyses and fluorescence in situ hybridization to make a pathology diagnosis and to investigate the tumour features. MYC amplification and c-Myc protein overexpression were positively detected. It might be possible to correlate the effectiveness of the gemcitabine-based chemotherapeutic regimen with MYC gene amplification and c-Myc protein overexpression.
authors.affiliation: Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yonezawa
authors.affiliation: Cell Biology and Anatomy, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Waki
authors.affiliation: Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Onoda
authors.affiliation: Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Narushima
authors.affiliation: Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishizuka
authors.affiliation: Pathology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tajima
keywords: Angiosarcoma; MYC; chemotherapy; gemcitabine; mucinous cystadenoma; surgical resection