title: Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review.
abstract: Due to their biodegradability, magnesium and magnesium-based alloys could represent the third generation of biomaterials. However, their mechanical properties and time of degradation have to match the needs of applications. Several approaches, such as choice of alloying elements or tailored microstructure, are employed to tailor corrosion behaviour. Due to the high electrochemical activity of Mg, numerous environmental factors (e.g. temperature and surrounding ion composition) influence its corrosion behaviour, making it unpredictable. Nevertheless, the need of reliable in vitro model(s) to predict in vivo implant degradation is increasing. In an attempt to find a correlation between in vitro and vivo corrosion rates, this review presents a systematic literature survey, as well as an attempt to correlate the different results.
authors.affiliation: Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany. Electronic address: adela.martinez@hzg.de.
authors.forename: Adela Helvia
authors.initials: AH
authors.lastname: Martinez Sanchez
authors.affiliation: Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany.
authors.forename: Bérengère J C
authors.initials: BJ
authors.lastname: Luthringer
authors.affiliation: Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Feyerabend
authors.affiliation: Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany.
authors.forename: Regine
authors.initials: R
authors.lastname: Willumeit
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003343:Corrosion; D006801:Humans; D008274:Magnesium / Q000493:pharmacokinetics / Q000494:pharmacology; D008954:Models, Biological
chemical_list: D000497:Alloys; D008274:Magnesium
keywords: Biodegradable metallic implants; Biomaterials; In vitro and in vivo corrosion; Magnesium alloys; Orthopaedics