title: Feasibility of optical coronary tomography in quantitative measurement of coronary arteries with lipid-rich plaque.
abstract: BACKGROUND
  The aim of the present study was to evaluate the feasibility of optical coherence tomography (OCT) for measurement of vessel area in coronary arteries with lipid-rich plaque as compared with intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 80 coronary artery segments with lipid-rich plaque on OCT and non-attenuated plaque on IVUS. According to the lipid arc on OCT, the plaques were classified into 4 groups: group 1, lipid arc ≤90°; group 2, 90°<lipid arc≤180°; group 3, 180°<lipid arc≤270°; group 4, lipid arc >270°. Vessel circular arcs that could not be identified due to OCT signal attenuation were interpolated using an approximating algorithm. OCT-measured vessel area was well-correlated with IVUS-measured vessel area (R=0.834, P<0.001). On Bland-Altman plot, there was a good agreement between OCT-measured vessel area and IVUS-measured vessel area, although mean difference and limits of agreement increased with increase of lipid arc (mean difference in groups 1-4: -0.21, -0.31, -1.02, and -2.13 mm(2); lower limit: -1.49, -3.22, -5.24, and -9.25 mm(2); and upper limit: 1.07, 2.60, 3.20, and 4.99 mm(2)). Intra-observer (R=0.97-0.99, P<0.001) and inter-observer (R=0.97-0.99, P<0.001) reproducibility for OCT measurement of vessel area was excellent.
  
  
  CONCLUSIONS
  Like IVUS, OCT can be used to measure vessel area in coronary arteries with lipid-rich plaque.
authors.affiliation: Department of Cardiovascular Medicine, Wakayama Medical University.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamano
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ino
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Shiono
authors.forename: Makoto
authors.initials: M
authors.lastname: Orii
authors.forename: Akira
authors.initials: A
authors.lastname: Taruya
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nishiguchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Shimokado
authors.forename: Ikuko
authors.initials: I
authors.lastname: Teraguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanimoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Kitabata
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hirata
authors.forename: Atsuhi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D041622:Tomography, Optical