title: CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas.
abstract: OBJECTIVE
  In previous CYP2D6 genotyping studies in Mexican-Amerindians a very low frequency of poor metabolizers (PMs) has been reported. Moreover, ultrarapid metabolizers (UMs) status has only been analyzed in some groups from Northern Mexico.
  
  
  METHODS
  In the present study we evaluated the hypothesis of low frequency of PMs in Mexican-Amerindians in Southern Mexican populations from Chiapas (Lacandones [ML] vs Mestizos [MM]). The frequency of UMs is also reported. CYP2D6 alleles *2, *3, *4, *5, *6, *10, *17, *35 and *41 and copy number variations were analyzed in 154 ML and 100 MM healthy volunteers.
  
  
  RESULTS
  The PM frequency was 0% in MLs and 1% in MMs, and for UMs was 2.6% in MLs and 3% in MMs.
  
  
  CONCLUSIONS
  The present data support previous findings reporting a very low frequency of CYP2D6 PMs in Mexican-Amerindians. Furthermore, the predicted UM phenotype in both MMs and MLs was lower than those reported for most Mexican populations.
authors.affiliation: Department of Biological Systems, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
authors.forename: Marisol
authors.initials: M
authors.lastname: López-López
authors.forename: Eva
authors.initials: E
authors.lastname: Peñas-Lledó
authors.forename: Pedro
authors.initials: P
authors.lastname: Dorado
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortega
authors.forename: Teresa
authors.initials: T
authors.lastname: Corona
authors.forename: Adriana
authors.initials: A
authors.lastname: Ochoa
authors.forename: Petra
authors.initials: P
authors.lastname: Yescas
authors.forename: Elisa
authors.initials: E
authors.lastname: Alonso
authors.forename: Adrián
authors.initials: A
authors.lastname: LLerena
mesh_terms: D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008297:Male; D008800:Mexico
chemical_list: D019389:Cytochrome P-450 CYP2D6
keywords: CYP2D6; Lacandones; Mexican–Mestizo; pharmacogenetics