title: Clinical heterogeneity in the same generation of siblings with GCK/MODY 2.
abstract: We report a peculiar case of a GCK/MODY2 family in whom monogenic and autoimmune diabetes coexist and exert different effects on clinical pictures, passing from mild hyperglycaemia not requiring any treatment through occasional insulin administration to complete insulin dependent type 1 diabetes.
authors.affiliation: Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy. Electronic address: giulio.maltoni2@unibo.it.
authors.forename: Giulio
authors.initials: G
authors.lastname: Maltoni
authors.affiliation: Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zucchini
authors.affiliation: Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy.
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Martini
authors.affiliation: Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Marasco
authors.affiliation: Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Vilma
authors.initials: V
authors.lastname: Mantovani
authors.affiliation: Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pession
mesh_terms: D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005941:Glucokinase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000201:enzymology / Q000235:genetics; D007328:Insulin / Q000627:therapeutic use
chemical_list: D007328:Insulin; D005941:Glucokinase
keywords: Autoimmunity; Diabetes; Glucokinase