title: Molecular actions of ovarian cancer G protein-coupled receptor 1 caused by extracellular acidification in bone.
abstract: Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. bjjq88@163.com.
authors.forename: Feng-Lai
authors.initials: FL
authors.lastname: Yuan
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. zhaomingdong@medmail.com.cn.
authors.forename: Ming-Dong
authors.initials: MD
authors.lastname: Zhao
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. j198611@163.com.
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Jiang
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. 13788999017@163.com.
authors.forename: Hui-Ren
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. caolu922@126.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. zhou.xiaogang@zs-hospital.sh.cn.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Zhou
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. li.xilei2@gmail.com.
authors.forename: Xi-Lei
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. dong.jian@zs-hospital.sh.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Dong
mesh_terms: D000143:Acids / Q000378:metabolism*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism*; D011522:Protons; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D000143:Acids; D011522:Protons; D043562:Receptors, G-Protein-Coupled