title: Histamine skin reactivity increases with body mass index in Korean children.
abstract: OBJECTIVE
  Histamine skin prick testing is most commonly used to diagnose immunoglobulin E (IgE)-mediated allergic diseases, and histamine reactivity is used as a standardized positive control in the interpretation of a skin prick test. However, reactivity to histamine differs among individuals for reasons that are poorly understood. The present study aimed to evaluate the potential association between body mass index (BMI) and histamine skin reactivity in children.
  
  
  METHODS
  A total of 451 children (246 boys, 205 girls) aged 7-8 years were enrolled in this study. The skin prick test was performed with 26 aeroallergens commonly found in Korea. Other information was collected, including sex, age, BMI, parental allergy history, and parental smoking status. Multivariate analysis was used to confirm the association between histamine skin reactivity and BMI.
  
  
  RESULTS
  The histamine wheal size was revealed to be associated with BMI (Spearman's Rho 0.161, p<0.001). This association was confirmed by multivariate analysis, after adjusting for sex, age, parental allergy history, parental smoking status, and allergic sensitization (coefficient B 0.071, 95% confidence interval 0.030-0.112).
  
  
  CONCLUSIONS
  Skin responses to histamine were primarily correlated with increased BMI. Further studies are needed to understand the clinical implication of BMI when interpreting the results of skin prick test.
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Ju Wan
authors.initials: JW
authors.lastname: Kang
authors.affiliation: The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, South Korea.
authors.forename: Keun-Hwa
authors.initials: KH
authors.lastname: Lee
authors.affiliation: The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, South Korea.
authors.forename: Seong-Chul
authors.initials: SC
authors.lastname: Hong
authors.affiliation: The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, South Korea.
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Lee
authors.affiliation: The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, South Korea.
authors.forename: Jaechun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: entman@yuhs.ac.
authors.forename: Chang-Hoon
authors.initials: CH
authors.lastname: Kim
authors.affiliation: The Environmental Health Center (Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, South Korea; Department of Otorhinolaryngology, Jeju National University School of Medicine, Jeju, South Korea. Electronic address: jeonghongkimmd@gmail.com.
authors.forename: Jeong Hong
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000485:Allergens; D044466:Asian People; D015992:Body Mass Index; D002648:Child; D005260:Female; D006632:Histamine / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000208:ethnology; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D015999:Multivariate Analysis; D056910:Republic of Korea; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D006632:Histamine
keywords: Allergy; Body mass index; Children; Histamine; Skin prick test; Skin reactivity