title: [Computer modeling of spatial-time distribution of metabolite concentrations in phantoms of biological objects by example of rat brain pial].
abstract: A method for quantitative assessment of the metabolite concentrations in digital phantoms of the biological objects has been proposed. The objects under consideration are expected to have a complex geometry of diffusive sources. We present an algorithm for calculation of non-steady state gradients of the diffusing compounds under their constant border concentration. The algorithm is based on the analytical solutions for a centrally symmetric spherical source. Spatial-time distribution of metabolites is considered by the example of glucose diffusion around blood vessels in the rat brain pial. It was shown that glucose level in the tissue was increased after glycine treatment and under condition of other biological system parameters to be unchanged.
authors.forename: Ia R
authors.initials: IaR
authors.lastname: Nartsissov
authors.forename: E S
authors.initials: ES
authors.lastname: Tiukina
authors.forename: S E
authors.initials: SE
authors.lastname: Boronovskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Sheshegova
mesh_terms: D000465:Algorithms; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D004058:Diffusion; D005947:Glucose / Q000378:metabolism; D051381:Rats
chemical_list: D005947:Glucose