title: Nuclear translocation of proteins and the effect of phosphatidic acid.
abstract: Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm.
authors.affiliation: a National Key Laboratory of Plant Molecular Genetics ; Institute of Plant Physiology and Ecology; Chinese Academy of Sciences ; Shanghai , China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yao
authors.forename: Geliang
authors.initials: G
authors.lastname: Wang
authors.forename: Xuemin
authors.initials: X
authors.lastname: Wang
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D017360:Arabidopsis / Q000187:drug effects / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism; D008954:Models, Biological; D019913:Nuclear Localization Signals / Q000378:metabolism; D010712:Phosphatidic Acids / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D019913:Nuclear Localization Signals; D010712:Phosphatidic Acids; D011956:Receptors, Cell Surface
keywords: Arabidopsis; NLS, nuclear localization signal; NPCs, nuclear pore complexes; PA, phosphatidic acid; PLD, phospholipase D.; PtdIns(5)P, Phosphatidylinositol-5-bisphosphate; nuclear localization signal; phosphatidic acid; phospholipid; protein nuclear import