title: A signaling-induced switch in dicer localization and function.
abstract: In this issue of Developmental Cell, Drake and colleagues (2014) report that Ras signaling results in Dicer phosphorylation, which induces its nuclear localization and modulates its function. This regulatory strategy, conserved in mammals, allows dynamic control of microRNA function required for Caenorhabditis elegans germline development and oogenesis.
authors.affiliation: Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Avenue, Box 252, New York, NY 10065, USA.
authors.forename: Fuqu
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Avenue, Box 252, New York, NY 10065, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lai
authors.affiliation: Temasek Life Sciences Laboratory, 1 Research Link 117604 and School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 639798 Singapore. Electronic address: okamurak@tll.org.sg.
authors.forename: Katsutomo
authors.initials: K
authors.lastname: Okamura
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism*; D012330:RNA, Double-Stranded / Q000378:metabolism*; D043244:Ribonuclease III / Q000378:metabolism*
chemical_list: D012330:RNA, Double-Stranded; D043244:Ribonuclease III