title: Sequential synthesis of coordination polymersomes.
abstract: Novel organic-inorganic hybrid liposomes, so-called coordination polymersomes (CPsomes), with artificial domains that exhibit strong lateral cohesion were prepared by a three-step procedure that formed a coordinative interaction leading to a lipid bilayer. First, the lipophilic complex (dabco-C18)[Mn(N)(CN)4(dabco-C18)] (1; dabco-C18(+)=1,4-diazabicyclo[2,2,2]octane-(CH2)17-CH3 cation), was synthesized. 1 has a lipophilic alkyl tail part and a tetracyanometallate head group, which can be used for an expansion to two-dimensional coordination networks. Second, 1 and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine were mixed to prepare the liposomes. Finally, CPsomes were obtained by the addition of transition-metal ions (M) to form unilamellar faceted liposomes with plain CP raft domains with Mn-CN-M linkages. The concentration of 1 influences the size of the CP raft domains and the shape of the CPsomes. The synthesis of coordination polymers in lipid bilayers is a novel approach for the construction of artificial architectures as raft domains, for example, in cell membranes.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510 (Japan).
authors.forename: Ryo
authors.initials: R
authors.lastname: Ohtani
authors.forename: Munehiro
authors.initials: M
authors.lastname: Inukai
authors.forename: Yuh
authors.initials: Y
authors.lastname: Hijikata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ogawa
authors.forename: Mikihito
authors.initials: M
authors.lastname: Takenaka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ohba
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitagawa
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry
chemical_list: D003486:Cyanides; D007477:Ions; D008051:Lipid Bilayers; D008081:Liposomes; D011108:Polymers; D028561:Transition Elements; D015060:1,2-Dipalmitoylphosphatidylcholine
keywords: coordination polymers; liposomes; nanostructures; supramolecular chemistry