title: Efficacy of adefovir dipivoxil therapy in patients with chronic hepatitis B viral infection.
abstract: Hepatitis B virus (HBV) infection is a major public health problem in the world. About 30% of world population has serological evidence of HBV infection. The prevalence of chronic hepatitis B in Bangladesh is reported to be 7.8%. Several potentially effective agents with different mechanisms of action have entered clinical practice and adefovir dipivoxil is one of them. Studies on the efficacy of adefovir dipivoxil in Bangladeshi patients are lacking. This was a prospective study to find out the effect of one year adefovir therapy in patients with chronic hepatitis B virus infection who were HBeAg positive. Total number of patients included in this study was 68. Among them 53(77.94%) patients continued the therapy and completed follow up. At the end of one year of therapy, intention to treat analysis showed that the rate of response (HBeAg seroconversion and HBV DNA negative) was 37.73% which was comparable to the results obtained in other studies. There was major difference in the pre treatment serum ALT level between the responders and non-responders. Comparison of reduction of serum ALT level before treatment and after treatment showed that ALT level to be lower in both responder group and non responder group. Adefovir was effective in replicative HBV infection in Bangladeshi population. So we suggest that treatment can be started and subsequent follow up can be done in chronic HBV patients who are HBeAg positive without liver biopsy.
authors.affiliation: Dr Md Masudur Rahman Khan, Associate Professor, Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: M S
authors.initials: MS
authors.lastname: Chowdhury
authors.forename: M
authors.initials: M
authors.lastname: Saha
authors.forename: S M
authors.initials: SM
authors.lastname: Roknuzzaman
authors.forename: M
authors.initials: M
authors.lastname: Mahmuduzzaman
authors.forename: A R
authors.initials: AR
authors.lastname: Miah
authors.forename: P K
authors.initials: PK
authors.lastname: Roy
authors.forename: M A
authors.initials: MA
authors.lastname: Raihan
authors.forename: K M
authors.initials: KM
authors.lastname: Rahman
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D001459:Bangladesh; D016903:Drug Monitoring / Q000379:methods; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000187:drug effects / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic; D063065:Organophosphonates / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D006513:Hepatitis B e Antigens; D063065:Organophosphonates; D000225:Adenine; C106812:adefovir dipivoxil