title: PET tracers for somatostatin receptor imaging of neuroendocrine tumors: current status and review of the literature.
abstract: Neuroendocrine tumors have shown rising incidence mainly due to higher clinical awareness and better diagnostic tools over the last 30 years. Functional imaging of neuroendocrine tumors with PET tracers is an evolving field that is continuously refining the affinity of new tracers in the search for the perfect neuroendocrine tumor imaging tracer. (68)Ga-labeled tracers coupled to synthetic somatostatin analogs with differences in affinity for the five somatostatin receptor subtypes are now widely applied in Europe. Comparison of sensitivity between the most used tracers - (68)Ga-DOTA-Tyr3-octreotide, (68)Ga-DOTA-Tyr3-octreotate and (68)Ga-DOTA-l-Nal3-octreotide - shows little difference and expertise on the specific tracer used, and knowledge regarding physiological uptake might be more important than in vitro-proven differences in affinity. Using isotopes such as (18)F or (64)Cu might improve these PET tracers further.
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET & Cluster for Molecular Imaging, Rigshospitalet & University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
authors.forename: Camilla Bardram
authors.initials: CB
authors.lastname: Johnbeck
authors.forename: Ulrich
authors.initials: U
authors.lastname: Knigge
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjær
mesh_terms: D006801:Humans; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000737:chemistry; D017481:Receptors, Somatostatin / Q000737:chemistry / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin
keywords: 18F-DOPA; 64Cu-DOTATATE; 68Ga-DOTANOC; 68Ga-DOTATATE; 68Ga-DOTATOC; PET imaging; cancer; molecular imaging; neuroendocrine tumors; somatostatin receptor imaging