title: A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells.
abstract: Inner ear hair cells transduce sound waves and acceleration. In the quest to identify the molecular machinery underlying mechanoelectrical transduction, Zhao et al. (2014) in this issue of Neuron reveal that the TMIE protein, essential for hearing, physically interacts with tip link protein protocadherin-15.
authors.affiliation: Duke University Departments of Neurology, Neurobiology and Anesthesiology, Duke University Clinics for Pain and Palliative Care, Durham, NC 27710, USA. Electronic address: wolfgang@neuro.duke.edu.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Liedtke
mesh_terms: D000818:Animals; D000070585:Cadherin Related Proteins; D015820:Cadherins / Q000378:metabolism*; D006198:Hair Cells, Auditory / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000235:genetics*; D008565:Membrane Proteins / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*
chemical_list: C418976:CDHR15 protein, mouse; D000070585:Cadherin Related Proteins; D015820:Cadherins; D008565:Membrane Proteins; D011498:Protein Precursors; C530887:Tmie protein, mouse