title: Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging.
abstract: In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries showed that this combined system is capable of providing high resolution, deep penetration depth and specific molecular fluorescence contrast simultaneously.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liang
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.forename: Joseph
authors.initials: J
authors.lastname: Jing
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Jiawen
authors.initials: J
authors.lastname: Li
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004724:Endoscopy / Q000295:instrumentation*; D006801:Humans; D064847:Multimodal Imaging / Q000295:instrumentation*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014463:Ultrasonography