title: CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites.
abstract: The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.
authors.affiliation: Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA.
authors.forename: Marcus Cs
authors.initials: MC
authors.lastname: Lee
authors.affiliation: Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA ; Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Fidock