title: Eosinophilic esophagitis: an emerging disease in childhood - review of diagnostic and management strategies.
abstract: Eosinophilic esophagitis is a chronic immune/antigen mediated inflammatory disease of the esophagus. It comprises a separate entity of increasing incidence and prevalence in children and adults. The disease is characterized by histological evidence of dense esophageal tissue eosinophilia in the presence of a variety of upper GI symptoms including vomiting, dysphagia, food impaction, and odynophagia. Cornerstone of treatment is dietary intervention and/or the off-label use of swallowed topical corticosteroids. New drug therapies are under investigation. In this review, we focus on the diagnostic approach and the currently available treatment strategies.
authors.affiliation: First Department of Pediatrics, Athens Children's Hospital "Agia Sofia", University of Athens , Athens , Greece.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papadopoulou
authors.affiliation: Department of Pediatrics, Hospital S. João , Porto , Portugal.
authors.forename: Jorge Amil
authors.initials: JA
authors.lastname: Dias
keywords: amino acid-based formula; empiric elimination diet; eosinophilic esophagitis; fluticasone propionate; oral steroids; oral viscous budesonide; targeted elimination diet