title: Metabolic control via the mitochondrial protein import machinery.
abstract: Mitochondria have to import most of their proteins in order to fulfill a multitude of metabolic functions. Sophisticated import machineries mediate targeting and translocation of preproteins from the cytosol and subsequent sorting into their suborganellar destination. The mode of action of these machineries has been considered for long time as a static and constitutively active process. However, recent studies revealed that the mitochondrial protein import machinery is subject to intense regulatory mechanisms that include direct control of protein flux by metabolites and metabolic signalling cascades.
authors.affiliation: Institut für Biochemie und Molekularbiologie, ZBMZ, Germany.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Opalińska
authors.affiliation: Institut für Biochemie und Molekularbiologie, ZBMZ, Germany; BIOSS Centre for Biological Signalling Studies, Germany. Electronic address: chris.meisinger@biochemie.uni-freiburg.de.
authors.forename: Chris
authors.initials: C
authors.lastname: Meisinger
mesh_terms: D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction; D015003:Yeasts / Q000166:cytology / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins