title: Well-defined biohybrids using reversible-deactivation radical polymerization procedures.
abstract: The use of reversible deactivation radical polymerization (RDRP) methods has significantly expanded the field of bioconjugate synthesis. RDRP procedures have allowed the preparation of a broad range of functional materials that could not be realized using prior art poly(ethylene glycol) functionalization. The review of procedures for synthesis of biomaterials is presented with a special focus on the use of RDRP to prepare biohybrids with proteins, DNA and RNA.
authors.affiliation: Laboratory for Bimolecular Medicine, Allegheny Health Network Research Institute, 320 E. North St., Pittsburgh, PA 15212, USA. Electronic address: saverick@WPAHS.org.
authors.forename: Saadyah
authors.initials: S
authors.lastname: Averick
authors.affiliation: Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA. Electronic address: Ryan.Mehl@oregonstate.edu.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Mehl
authors.affiliation: Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: srdas@andrew.cmu.edu.
authors.forename: Subha R
authors.initials: SR
authors.lastname: Das
authors.affiliation: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: km3b@andrew.cmu.edu.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Matyjaszewski
mesh_terms: D001672:Biocompatible Materials; D002626:Chemistry, Pharmaceutical; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins; D012313:RNA; D004247:DNA
keywords: ATRP; Bioconjugates; Biohybrids; Polymer; RAFT; RDRP