title: Do we need 'new' omega-3 polyunsaturated fatty acids formulations?
abstract: The therapeutic value of omega-3 polyunsaturated fatty acids (PUFAs), mainly (but not only) found in fish oils, eicosapentaenoic and docosahexaenoic acids (EPA and DHA, respectively), has been extensively studied in a wide variety of disease conditions, predominantly in cardiovascular disease. However, the significant difference in efficacy observed in various conditions with different dosages seems to be at least partly related to the large discrepancy in quality of the product and to the bioavailability of the omega-3 PUFA. The research of new sources (e.g., from arctic Krill oil) and pharmaceutical forms of omega-3 PUFA (e.g., omega-3 carboxylic acids) is needed in order to detect the one with the best bioavailability and efficacy, and with a parallel reduction in the production costs. There is also the need to understand if long-term PUFA supplementation could increase the efficacy of the already-available evidence-based therapies for cardiovascular disease prevention and for the management of the diseases where the use of PUFA could have a possible improving effect.
authors.affiliation: Alma Mater Studiorum University of Bologna, Medical and Surgical Sciences Department , Bologna , Italy.
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
authors.forename: Martino
authors.initials: M
authors.lastname: Morbini
authors.forename: Claudio
authors.initials: C
authors.lastname: Borghi
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000008:administration & dosage; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005395:Fish Oils / Q000737:chemistry
chemical_list: D005230:Fatty Acids, Nonesterified; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
keywords: bioavailability; docosahexaenoic acid; eicosapentaenoic acid; fish oil; polyunsaturated fatty acid