title: One-generation reproduction study of esterified propoxylated glycerol (EPG) administered in the feed to CD® (Sprague-Dawley) rats.
abstract: This one-generation study assessed the potential of esterified propoxylated glycerol (EPG) to affect reproduction and offspring development in rats. Male and female Crl:CD(SD)BR rats (30/sex/group) were exposed to EPG at 0, 0.5, 1, and 2g/kg bw/day or at 5% (w/w) in the diet prior to (13 weeks), during, and after two consecutive matings. For dams, exposure continued through gestation and lactation; F1a and F1b pups were weaned to the respective diet (for up to 91 days). No consistent treatment-related effects were observed in: body weights/gains; feed consumption; clinical observations; mating indices; survival, growth and development of litters, litter sizes, body weights, sex ratios (lower % males/litter at 1 and 2g/kg bw/day), acquisition of developmental landmarks, behavioral indices, or histology of selected organs. Lower serum vitamin D, liver vitamin A, and liver vitamin E levels were seen in some EPG-treated groups. None of the reductions were judged to be biologically significant. A/G ratio was greater among males receiving 2g/kg bw/day and 5%. In the absence of any other related effects, the biological significance of this finding is doubtful.
authors.affiliation: RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, PO Box 12194, United States.
authors.forename: Rochelle W
authors.initials: RW
authors.lastname: Tyl
authors.affiliation: Best Foods, Division of CPC International, 150 Pierce St., Somerset, NJ 08873, United States. Electronic address: david.bechtel@intertek.com.
authors.forename: David H
authors.initials: DH
authors.lastname: Bechtel
mesh_terms: D000818:Animals; D004032:Diet; D019358:Fat Substitutes / Q000633:toxicity*; D005260:Female; D005989:Glycerides / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*
chemical_list: D019358:Fat Substitutes; D005989:Glycerides
keywords: EPG; Esterified propoxylated glycerol; Fat substitute; One-generation; Reproductive toxicity