title: Poly(ethylene glycol) dicarboxylate/poly(ethylene oxide) hydrogel film co-crosslinked by electron beam irradiation as an anti-adhesion barrier.
abstract: The cross-linked poly(ethylene glycol) dicarboxylate (PEGDC)/poly(ethylene oxide) (PEO) and poly(ethylene glycol) dimethacrylate (PEGDMA)/(PEO) hydrogels were developed for possible biomedical applications such as an anti-adhesion barrier. Various contents of PEGDC/PEO film were irradiated using an electron beam with various beam intensities in order to obtain various degrees of crosslinked hydrogels. The optimum dose (300 kGy) and total crosslinker content of 10% were used to prepare crosslinked hydrogel films with three different compositions (10% PEGDC, 10% PEGDMA, 5% PEGDC-5% PEGDMA). Among them, 10% PEGDC hydrogel film exhibited the highest elongation at break (69.33±6.87%) with high mechanical strength. 10% PEGDC hydrogel film showed the lowest hemolysis activity (6.03±0.01%) and the highest tissue adherence (75.67±1.15 cN). The result also indicated that the carboxyl groups in PEGDC affect the tissue adherence of hydrogel films via H-bonding interactions. In animal studies, 10% PEGDC anti-adhesion hydrogel film degraded within 3 weeks and demonstrated better anti-adhesive effect compared to Guardix-SG®.
authors.affiliation: Department of Advanced Organic Materials Engineering, Yeungnam University, Gyongbuk 712-749, Republic of Korea.
authors.lastname: Haryanto
authors.affiliation: Department of Advanced Organic Materials Engineering, Yeungnam University, Gyongbuk 712-749, Republic of Korea.
authors.forename: Deepti
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Advanced Organic Materials Engineering, Yeungnam University, Gyongbuk 712-749, Republic of Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, College of Medicine, Yeungnam University, Gyongbuk 712-749, Republic of Korea.
authors.forename: Jun Hyuk
authors.initials: JH
authors.lastname: Son
authors.affiliation: Department of Advanced Organic Materials Engineering, Yeungnam University, Gyongbuk 712-749, Republic of Korea. Electronic address: sckim07@ynu.ac.kr.
authors.forename: Seong Cheol
authors.initials: SC
authors.lastname: Kim
mesh_terms: D000818:Animals; D020100:Hydrogels; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols
keywords: Anti-adhesion barrier; Crosslinked hydrogel; Electron beam; Elongation at break; Polyethyleneglycol dicarboxylate; Tensile strength