title: Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.
abstract: In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Vance
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Rong
authors.affiliation: Soligenix, Inc., Princeton, NJ, USA.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Brey
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, University at Albany, Albany, NY, USA. Electronic address: nicholas.mantis@health.ny.gov.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Mantis
mesh_terms: D000818:Animals; D000881:Anthrax / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000008:administration & dosage / Q000276:immunology*; D057134:Antibodies, Neutralizing / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology; D000992:Antitoxins / Q000097:blood; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D008807:Mice, Inbred BALB C; D011041:Poisoning / Q000517:prevention & control*; D012276:Ricin / Q000037:antagonists & inhibitors* / Q000276:immunology; D016019:Survival Analysis; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
chemical_list: D022122:Anthrax Vaccines; D057134:Antibodies, Neutralizing; D000942:Antigens, Bacterial; D000992:Antitoxins; D001427:Bacterial Toxins; C509236:RiVax; D014612:Vaccines; D017778:Vaccines, Combined; D022223:Vaccines, Subunit; C030325:anthrax toxin; D012276:Ricin
keywords: Antigen; Biodefense; Toxin; Vaccine