title: Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation.
abstract: Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex nitrogenous structures ideally functionalized for medicinal applications. Isonitrile insertion into transition metal complexes has featured in numerous synthetic and mechanistic studies, leading to rapid deployment of isonitriles in numerous catalytic processes, including multicomponent reactions (MCR). Covering the literature from 1990-2014, the present review collates reaction types to highlight reactivity trends and allow catalyst comparison.
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Suravi
authors.initials: S
authors.lastname: Chakrabarty
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Shruti
authors.initials: S
authors.lastname: Choudhary
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Arpit
authors.initials: A
authors.lastname: Doshi
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Fa-Qiang
authors.initials: FQ
authors.lastname: Liu
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Rishabh
authors.initials: R
authors.lastname: Mohan
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Manasa P
authors.initials: MP
authors.lastname: Ravindra
authors.affiliation: Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Dhruv
authors.initials: D
authors.lastname: Shah
authors.affiliation: Department of Chemistry, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Xun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Duquesne University, Pittsburgh, PA 15282-1530, USA.
authors.forename: Fraser F
authors.initials: FF
authors.lastname: Fleming
keywords: catalysis; condensation; coupling; isocyanides; isonitriles