title: Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).
abstract: BACKGROUND
  Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals; EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited.
  
  
  OBJECTIVE
  We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153).
  
  
  METHODS
  We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation.
  
  
  RESULTS
  We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; p trend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; p trend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa.
  
  
  CONCLUSIONS
  Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1085, IRSET, Pointe à Pitre, Guadeloupe, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Emeville
authors.forename: Arnaud
authors.initials: A
authors.lastname: Giusti
authors.forename: Xavier
authors.initials: X
authors.lastname: Coumoul
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Thomé
authors.forename: Pascal
authors.initials: P
authors.lastname: Blanchet
authors.forename: Luc
authors.initials: L
authors.lastname: Multigner
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood* / Q000633:toxicity; D052244:Endocrine Disruptors / Q000633:toxicity; D004785:Environmental Pollutants / Q000009:adverse effects; D019430:Guadeloupe / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000633:toxicity; D011471:Prostatic Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls