title: One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.
abstract: The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoromethylketones yields α-CF3 morpholines and piperazines.
authors.affiliation: Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
authors.forename: Woon-Yew
authors.initials: WY
authors.lastname: Siau
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bode
mesh_terms: D000588:Amines / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D055808:Drug Discovery; D007202:Indicators and Reagents / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000588:Amines; D007202:Indicators and Reagents; D007659:Ketones; D013141:Spiro Compounds