title: Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.
abstract: Tumor necrosis factor-alpha-induced protein-8 like-3 (TNFAIP8L3, TIPE3) is a newly discovered member of TNFAIP8 family and regarded as a lipid second messenger transfer protein that promotes cancer. Yet the nature of the cells and tissues that express TIPE3 protein has not been determined. In this study, we examined TIPE3 expression in various murine and human tissues by immunohistochemistry and quantitative PCR. We found that TIPE3 expression was almost identical in most organs from human and mice. TIPE3 is a cytoplasmic protein expressed preferentially in epithelial-derived cells with secretory functions. Furthermore, TIPE3 protein is highly expressed in most human carcinoma cell lines. These results suggest that TIPE3 may play important roles in carcinogenesis and cell secretion.
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Pathology, Shandong University School of Medicine, Ji'nan, P.R. China. (CH)
authors.forename: Chunyan
authors.initials: C
authors.lastname: Hao
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Wenqian
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Jie
authors.initials: J
authors.lastname: Shao
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Guizhong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Shandong University School of Medicine, Ji'nan, P.R. China(JC, WZ, JS, NZ, GZ, SL)
authors.forename: Suxia
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics; D002277:Carcinoma / Q000235:genetics; D002460:Cell Line; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis* / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D059467:Transcriptome
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C000597332:TIPE3 protein, mouse; C000593651:TNFAIP8L3 protein, human
keywords: TNFAIP8L3 (TIPE3); carcinogenesis; expression; secretion