title: Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects.
abstract: As candidate genes of attention--deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on the X chromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I). The present study is to investigate the potential gene-gene interaction (G × G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family-based association study, 177 female trios were included. For case-control study, 1,462 probands and 807 normal controls were recruited. The ADHD Rating Scale-IV (ADHD-RS-IV) was used to evaluate ADHD symptoms. Pedigree-based generalized multifactor dimensionality reduction (PGMDR) for female ADHD trios indicated significant gene interaction effect of rs5905859 and rs5906754. Generalized multifactor dimensionality reduction (GMDR) indicated potential gene-gene interplay on ADHD RS-IV scores in female ADHD-I. No associations were observed in male subjects in case-control analysis. In conclusion, our findings suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype and predict ADHD symptoms.
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Hai-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Yi-Lang
authors.initials: YL
authors.lastname: Tang
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Qiu-Jin
authors.initials: QJ
authors.lastname: Qian
mesh_terms: D019958:Attention Deficit and Disruptive Behavior Disorders / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D016708:Synaptophysin / Q000235:genetics*
chemical_list: C569014:SYP protein, human; D016708:Synaptophysin; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: ADHD; MAOA; SYP; gene; interaction