title: Intereye Comparison of Cirrus OCT in Early Glaucoma Diagnosis and Detecting Photographic Retinal Nerve Fiber Layer Abnormalities.
abstract: OBJECTIVE
  To compare the ability of various maps constructed using Cirrus optical coherence tomography (OCT), including the "intereye comparison" derived from the temporal superior inferior nasal temporal (TSNIT) map, in terms of glaucoma diagnosis and detection of RNFL defects identified in red-free fundus photographs.
  
  
  METHODS
  This cross-sectional study was conducted on a total of 131 open-angle glaucoma patients with early-stage visual field defects (mean deviation ≤ -6.0 dB) and 56 healthy controls. Intereye differences were identified on TSNIT maps constructed by comparing the RNFL thickness curves of both eyes of individual patients and a separation of the RNFL thickness curves of either eye (by >50 μm) was defined as an abnormality.
  
  
  RESULTS
  Among 131 red-free fundus photographic RNFL defects, 57 (44.0%) in the Clock-hour map, 51 (39.0%) in the Quadrant map, 37 (28%) in the Deviation map, 16 (12%) in the Thickness map, and 3 (2%) in the intereye difference obtained from the TSNIT map were misidentified. The intereye difference derived from the TSNIT map afforded a sensitivity superior to that of all other maps when used to evaluate eyes with glaucoma (98.0%, all P values < 0.05), and preperimetric eyes (97.7%, all P values < 0.001).
  
  
  CONCLUSIONS
  Of the various maps constructed by the Cirrus OCT, comparison of the RNFL thickness curves of both eyes of an individual, which was possible using TSNIT map data, afforded the best diagnostic capability in terms of detecting photographic RNFL defects. Intereye comparisons of TSNIT thickness curves may be useful to detect early-stage glaucoma.
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea Seoul St. Mary's Hospital, Seoul, South Korea.
authors.forename: Hae-Young Lopilly
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea Uijungbu St. Mary's Hospital, Uijungbu, South Korea.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Shin
authors.affiliation: Department of Ophthalmology, Saevit Eye Hospital, Gyeonggi, Korea.
authors.forename: Jae-Yoon
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea Seoul St. Mary's Hospital, Seoul, South Korea.
authors.forename: Younhea
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea Seoul St. Mary's Hospital, Seoul, South Korea.
authors.forename: Chan Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D010781:Photography; D012372:ROC Curve; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Cirrus optical coherence tomography; glaucoma; intereye comparison