title: Simulation environment and graphical visualization environment: a COPD use-case.
abstract: BACKGROUND
  Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which in turn simplify the communication among models. Nevertheless, not all of these tools are able to run models written in different programming languages. In addition, interoperability between such models remains an unresolved issue.
  
  
  RESULTS
  In this paper we present a simulation environment that allows, first, the execution of models developed in different programming languages and second the communication of parameters to interconnect these models. This simulation environment, developed within the Synergy-COPD project, aims at helping and supporting bio-researchers and medical students understand the internal mechanisms of the human body through the use of physiological models. This tool is composed of a graphical visualization environment, which is a web interface through which the user can interact with the models, and a simulation workflow management system composed of a control module and a data warehouse manager. The control module monitors the correct functioning of the whole system. The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules.
  
  
  CONCLUSIONS
  It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment. A new tool for bio-researchers is ready for deployment in various use cases scenarios.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Huertas-Migueláñez
authors.forename: Daniel
authors.initials: D
authors.lastname: Mora
authors.forename: Isaac
authors.initials: I
authors.lastname: Cano
authors.forename: Dieter
authors.initials: D
authors.lastname: Maier
authors.forename: David
authors.initials: D
authors.lastname: Gomez-Cabrero
authors.forename: Magí
authors.initials: M
authors.lastname: Lluch-Ariet
authors.forename: Felip
authors.initials: F
authors.lastname: Miralles
mesh_terms: D003142:Communication; D003196:Computer Graphics; D003198:Computer Simulation; D016208:Databases, Factual; D006801:Humans; D008962:Models, Theoretical; D011336:Probability; D016730:Program Development; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012984:Software; D014584:User-Computer Interface