title: Rapid Construction of (-)-Paroxetine and (-)-Femoxetine viaN-Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes.
abstract: A concise enantioselective synthesis of (-)-paroxetine (Paxil) and (-)-femoxetine has been achieved. Key to these syntheses is aN-heterocyclic carbene catalyzed homoenolate addition to a nitroalkene followed by in situ reduction of the nitro-group to rapidly access δ-lactams.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: White
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).
authors.forename: Kerem E
authors.initials: KE
authors.lastname: Ozboya
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).
authors.forename: Darrin M
authors.initials: DM
authors.lastname: Flanigan
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).
authors.forename: Tomislav
authors.initials: T
authors.lastname: Rovis