title: miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma.
abstract: miR-200a suppresses tumor development and progression; however, its role in tumor growth and metastasis of hepatocellular carcinoma (HCC) and the underlying mechanism have not been elucidated. In the present study, we identified that miR-200a was markedly downregulated in HCC and exerted suppressive effects on tumor cell growth and metastasis. We identified that miR-200a suppressed tumor growth and metastasis by directly targeting MACC1. In addition, HCC patients with low miR-200a expression had significantly worse prognosis than those with high expression of miR-200a. These findings suggest that miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation.
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Jiye
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Gun
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Zongyang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Ying
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhuo
authors.affiliation: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Jianlei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: C544162:MACC1 protein, human; C533896:MIRN200 microRNA, human; D035683:MicroRNAs; D015534:Trans-Activators; D014157:Transcription Factors