title: Dosimetric impact of the 160 MLC on head and neck IMRT treatments.
abstract: The purpose of this work is to investigate if the change in plan quality with the finer leaf resolution and lower leakage of the 160 MLC would be dosimetrically significant for head and neck intensity-modulated radiation therapy (IMRT) treat- ment plans. The 160 MLC consisting of 80 leaves of 0.5 cm on each bank, a leaf span of 20 cm, and leakage of less than 0.37% without additional backup jaws was compared against the 120 Millennium MLC with 60 leaves of 0.5 and 1.0 cm, a leaf span of 14.5 cm, and leakage of 2.0%. CT image sets of 16 patients previously treated for stage III and IV head and neck carcinomas were replanned on Prowess 5.0 and Eclipse 11.0 using the 160 MLC and the 120 MLC. IMRT constraints for both sets of 6 MV plans were identical and based on RTOG 0522. Dose-volume histograms (DVHs), minimum dose, mean dose, maximum dose, and dose to 1 cc to the organ at risks (OAR) and the planning target volume, as recommended by QUANTEC 2010, were compared. Both collimators were able to achieve the target dose to the PTVs. The dose to the organs at risk (brainstem, spinal cord, parotids, and larynx) were 1%-12% (i.e., 0.5-8 Gy for a 70 Gy prescription) lower with the 160 MLC compared to the 120 MLC, depending on the proximity of the organ to the target. The large field HN plans generated with the 160 MLC were dosimetrically advantageous for critical structures, especially those located further away from the central axis, without compromising the target volume.
authors.affiliation: University of Utah. prema.rassiah-szegedi@hci.utah.edu.
authors.forename: Prema
authors.initials: P
authors.lastname: Rassiah-Szegedi
authors.forename: Martin
authors.initials: M
authors.lastname: Szegedi
authors.forename: Vikren
authors.initials: V
authors.lastname: Sarkar
authors.forename: Seth
authors.initials: S
authors.lastname: Streitmatter
authors.forename: Y Jessica
authors.initials: YJ
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Bill
authors.initials: B
authors.lastname: Salter
mesh_terms: D002277:Carcinoma / Q000532:radiotherapy*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000592:standards; D050397:Radiotherapy, Intensity-Modulated