title: Clinical application of remifentanil in local anesthesia for tumor resection in functional brain area.
abstract: OBJECTIVE
  The aim of this study was to investigate clinical application of remifentanil in local anesthesia for resection of tumors in functional brain area.
  
  
  METHODS
  Twenty-four patients were randomly divided into two groups: control group and remifentanil group. In remifentanil group remifentanil was infused intravenously with micro pump in 0.05-0.1 µg·kg-1·min-1. The hemodynamic changes and complications during operation were monitored.
  
  
  RESULTS
  The satisfactory degree for surgical procedure was evaluated. The surgery of two groups could be completed in a conscious state. Mean artery pressure (MAP), heart rate (HR) in remifentanil group during opening or closing skull or intra- cranial period were significantly lower than control group (p < 0.05). There were no conspicuous complications in two groups such as respiratory depression, nausea, vomitting and dysphoria. Satisfaction rate of remifentanyl group was significantly higher than control group (p < 0.05).
  
  
  CONCLUSIONS
  Awake brain tumor surgery could be completed in rational use of remifentanil on the base of good local anesthesia, and hemodynamics were stable and the patients were well tolerated.
authors.affiliation: Department of Anesthesia of the First Affiliated Hospital, Xinxiang Medical University, Weihui, Henan, China. yqmhcn@126.com.
authors.forename: S-E
authors.initials: SE
authors.lastname: Cao
authors.forename: B-Q
authors.initials: BQ
authors.lastname: Gao
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Zhang
authors.forename: S-M
authors.initials: SM
authors.lastname: Yang
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Liu
authors.forename: X-R
authors.initials: XR
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000772:Anesthesia, Local / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005910:Glioma / Q000473:pathology / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage; D000077208:Remifentanil; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol