title: Rhinosinusitis in hematopoietic stem cell-transplanted patients: influence of nasosinus mucosal abnormalities?
abstract: BACKGROUND
  Rhinosinusitis is characterized by inflammation extending from the mucosa of the nasal cavity into the paranasal sinuses. There are some aggravating features, such as immunosuppression, that can cause the nasal mucosal inflammation to linger for a long period, resulting in chronic or recurrent episodes. Such immunosuppression is the major feature of patients undergoing a hematopoietic stem cell transplant (HSCT); rhinosinusitis prevalence is higher in this group compared to immunocompetent patients. Nasal epithelial abnormalities have been described in, and may have some influence over, recurrent sinus infections among those patients. However, it is not clear whether rhinosinusitis can trigger mucosal abnormalities or whether a preexisting vulnerability for sinusitis recurrence is more likely. The objective of the study was to verify the influence of rhinosinusitis on nasal epithelial damage in patients undergoing hematopoietic stem cell transplantation.
  
  
  METHODS
  A total of 30 allogeneic HSCT patients were divided into two groups: 24 patients with chronic or recurrent rhinosinusitis and 6 patients without rhinosinusitis. These patients underwent a biopsy of the uncinate process that was analyzed by transmission electron microscopy and optical microscopy.
  
  
  RESULTS
  The nasal mucosa analysis by optical microscopy showed no significant abnormalities. The ciliary orientation was obviously normal in the transplanted patients without rhinosinusitis. There was a trend toward a difference in the amount of cilia (decreased) and the primary modification of the ultrastructure of transplanted patients with rhinosinusitis.
  
  
  CONCLUSIONS
  HSCT patients, with and without rhinosinusitis, showed no significant histological abnormalities, except for ciliary disorientation and a possible decrease in ciliary and ultrastructural abnormalities in HSCT patients with rhinosinusitis.
authors.forename: Erica
authors.initials: E
authors.lastname: Ortiz
authors.forename: Albina
authors.initials: A
authors.lastname: Altemani
authors.forename: Afonso Celso
authors.initials: AC
authors.lastname: Vigorito
authors.forename: Eulalia
authors.initials: E
authors.lastname: Sakano
authors.forename: Ester Maria Danielli
authors.initials: EM
authors.lastname: Nicola
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000473:pathology*; D012220:Rhinitis / Q000276:immunology / Q000473:pathology*; D012852:Sinusitis / Q000276:immunology / Q000473:pathology*; D033581:Stem Cell Transplantation