title: Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity.
abstract: Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea; New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
authors.forename: Hunseung
authors.initials: H
authors.lastname: Yoo
authors.affiliation: College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.affiliation: College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Kim
authors.affiliation: New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
authors.forename: Minseok
authors.initials: M
authors.lastname: Kang
authors.affiliation: New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Ryu
authors.affiliation: College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Ahn
authors.affiliation: College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 420-743, Republic of Korea.
authors.forename: Kee Dong
authors.initials: KD
authors.lastname: Yoon
authors.affiliation: College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: jwkim@snu.ac.kr.
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification; D000001:Calcimycin / Q000494:pharmacology; D002460:Cell Line; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D027343:Rhizome / Q000737:chemistry / Q000378:metabolism; D029909:Sophora / Q000737:chemistry* / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: C000599489:2'-hydroxyglabrol; C000599492:3-methylmaackiapterocarpan B; D001572:Benzofurans; D044950:Flavanones; D005419:Flavonoids; D015850:Interleukin-6; D010936:Plant Extracts; D013729:Terpenes; D000001:Calcimycin; C105430:benzofuran; D013755:Tetradecanoylphorbol Acetate
keywords: Anti-allergy; Arylbenzofruran; Flavonoid; Interleukin-6; Sophora tonkinensis