title: Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: a novel case in infancy.
abstract: Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pediatric lymphoma despite their high prevalence in pediatric leukemia. We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement. We also briefly summarize the clinicopathologic significance of MLL gene rearrangements, and review the reported cases of pediatric ovarian lymphoma with and without MLL rearrangement.
authors.affiliation: *University of Minnesota Medical School †Department of Laboratory Medicine and Pathology, University of Minnesota Medical School ‡Department of Laboratory Medicine and Pathology, Children's Hospitals & Clinics of Minnesota §Department of Pediatric Hematology/Oncology, Children's Hospitals & Clinics of Minnesota.
authors.forename: Alyssa M
authors.initials: AM
authors.lastname: Larish
authors.forename: Michelle
authors.initials: M
authors.lastname: Dolan
authors.forename: Tim
authors.initials: T
authors.lastname: Casey
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Perkins
mesh_terms: D019070:Cell Lineage; D005260:Female; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D007223:Infant; D016393:Lymphoma, B-Cell / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase