title: Chemical sympathectomy increases neutrophil-to-lymphocyte ratio in tumor-bearing rats but does not influence cancer progression.
abstract: The sympathetic nervous system regulates many immune functions and modulates the anti-tumor immune defense response, too. Therefore, we studied the effect of 6-hydroxydopamine induced sympathectomy on selected hematological parameters and inflammatory markers in rats with Yoshida AH130 ascites hepatoma. We found that chemically sympathectomized tumor-bearing rats had significantly increased neutrophil-to-lymphocyte ratio, leukocyte-to-lymphocyte ratio, and plasma levels of tumor necrosis factor alpha. Although our findings showed that sympathetic denervation in tumor-bearing rats led to increased neutrophil-to-lymphocyte ratio, that is an indicator of the disease progression, we found no significant changes in tumor growth and survival of sympathectomized tumor-bearing rats.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia. Electronic address: ueenlack@savba.sk.
authors.forename: Lubica
authors.initials: L
authors.lastname: Horvathova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia.
authors.forename: Andrej
authors.initials: A
authors.lastname: Tillinger
authors.affiliation: Institute of Anatomy, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Sivakova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia.
authors.forename: Lucia
authors.initials: L
authors.lastname: Mikova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia.
authors.forename: Boris
authors.initials: B
authors.lastname: Mravec
authors.affiliation: Institute of Immunology, Faculty of Medicine, Comenius University, Odborarske namestie 14, 811 08 Bratislava, Slovakia.
authors.forename: Maria
authors.initials: M
authors.lastname: Bucova
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D018450:Disease Progression; D004912:Erythrocytes; D053208:Kaplan-Meier Estimate; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012517:Sarcoma, Yoshida / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D013154:Spleen / Q000378:metabolism; D013563:Sympathectomy, Chemical; D013565:Sympatholytics / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D013565:Sympatholytics; D014409:Tumor Necrosis Factor-alpha; D016627:Oxidopamine; D009638:Norepinephrine
keywords: Blood cells count; Chemical sympathectomy; Neutrophil-to-lymphocyte ratio; Rats; Tumor growth; Tumor necrosis factor alpha