title: Salinomycin Suppresses PDGFRβ, MYC, and Notch Signaling in Human Medulloblastoma.
abstract: Medulloblastoma (MB) is the most common childhood brain tumor. Despite improved therapy and management, approximately 30% of patients die of the disease. To search for a more effective therapeutic strategy, the effects of salinomycin were tested on cell proliferation, cell death, and cell cycle progression in human MB cell lines. The results demonstrated that salinomycin inhibits cell proliferation, induces cell death , and disrupts cell cycle progression in MB cells. Salinomycin was also tested on the expression levels of key genes involved in proliferation and survival signaling and revealed that salinomycin down-regulates the expression of PDGFRβ, MYC, p21 and Bcl-2 as well as up-regulates the expression of cyclin A. In addition, the results reveal that salinomycin suppresses the expression ofHes1andHes5in MB cells. Our data shed light on the potential of using salinomycin as a novel therapeutic agent for patients with MB.
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, USA.
authors.forename: Fengfei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Retina Consultants Ltd and University of North Dakota, USA.
authors.forename: Max R
authors.initials: MR
authors.lastname: Johnson
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Qian
authors.affiliation: Department of Basic Sciences, University of North Dakota, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, USA.
authors.forename: Erxi
authors.initials: E
authors.lastname: Wu
keywords: MYC; Medulloblastoma; Notch Signaling; PDGFRβ; Salinomycin