title: Time-warped geodesic regression.
abstract: We consider geodesic regression with parametric time-warps. This allows for example, to capture saturation effects as typically observed during brain development or degeneration. While highly-flexible models to analyze time-varying image and shape data based on generalizations of splines and polynomials have been proposed recently, they come at the cost of substantially more complex inference. Our focus in this paper is therefore to keep the model and its inference as simple as possible while allowing to capture expected biological variation. We demonstrate that by augmenting geodesic regression with parametric time-warp functions, we can achieve comparable flexibility to more complex models while retaining model simplicity. In addition, the time-warp parameters provide useful information of underlying anatomical changes as demonstrated for the analysis of corpora callosa and rat calvariae. We exemplify our strategy for shape regression on the Grassmann manifold, but note that the method is generally applicable for time-warped geodesic regression.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hong
authors.forename: Nikhil
authors.initials: N
authors.lastname: Singh
authors.forename: Roland
authors.initials: R
authors.lastname: Kwitt
authors.forename: Marc
authors.initials: M
authors.lastname: Niethammer
mesh_terms: D000293:Adolescent; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D002648:Child; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000254:growth & development*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated / Q000379:methods; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000033:anatomy & histology* / Q000254:growth & development*; D013382:Subtraction Technique; D055815:Young Adult