title: Molecular genetics of glioblastomas: defining subtypes and understanding the biology.
abstract: Despite comprehensive therapy, which includes surgery, radiotherapy, and chemotherapy, the prognosis of glioblastoma multiforme is very poor. Diagnosed individuals present an average of 12 to 18 months of life. This article provides an overview of the molecular genetics of these tumors. Despite the overwhelming amount of data available, so far little has been translated into real benefits for the patient. Because this is such a complex topic, the goal is to point out the main alterations in the biological pathways that lead to tumor formation, and how this can contribute to the development of better therapies and clinical care.
authors.affiliation: DASA, Rua João Borges 120/502, Gavea, Rio de Janeiro CEP 22451-100, Brazil. Electronic address: Zalcberg@inca.gov.br.
authors.forename: Ilana Zalcberg
authors.initials: IZ
authors.lastname: Renault
authors.affiliation: Symbiosis-Biotechnology Consultancy, Rio de Janeiro, Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: Golgher
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology / Q000379:methods*
keywords: Glioblastoma multiforme; Gliomas; Molecular genetics; Mutations