title: Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.
abstract: Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na(+) channels (NaVs). In this review, we discuss new insights into how FHFs modulate NaVs. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.
authors.affiliation: Ion Channel Research Unit, Duke University Medical Center, Durham, NC, USA Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Juan L
authors.initials: JL
authors.lastname: Pablo
authors.affiliation: Ion Channel Research Unit, Duke University Medical Center, Durham, NC, USA Department of Neurobiology, Duke University Medical Center, Durham, NC, USA Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA geoffrey.pitt@duke.edu.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Pitt
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism
chemical_list: D061566:Voltage-Gated Sodium Channels; D005346:Fibroblast Growth Factors
keywords: fibroblast growth factor homologous factors; fibroblast growth factors; neuron cell biology; spinocerebellar ataxia; voltage-gated sodium channels