title: A supramolecular vesicle of camptothecin for its water dispersion and controllable releasing.
abstract: Camptothecin, as an antitumor drug, has shown significant antitumor activity against various cancers through the inhibition of topoisomerase I. However, its poor solubility severely limits the clinical applications. Here, we report a camptothecin supramolecular vesicle based on the host-guest interactions, which can uniformly disperse camptothecin into water and greatly enhance camptothecin aqueous solubility. The camptothecin vesicles were identified by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scattering (DLS). X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), UV-vis spectrum, 1H NMR and 2D NMR ROESY were further employed to study the formation mechanism of the vesicles. Furthermore, camptothecin could be controllably released when the competitive guests were added into the vesicles system. Finally, the camptothecin vesicles in aqueous solution exhibited comparable antitumor activity in vitro as natural camptothecin in DMSO to HeLa cells under the same conditions.
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Mingfang
authors.initials: M
authors.lastname: Ma
authors.affiliation: Wuxi Medical School of Jiangnan University, Wuxi 214122, PR China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Shang
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Pengyao
authors.initials: P
authors.lastname: Xing
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Shangyang
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Chu
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China. Electronic address: haoay@sdu.edu.cn.
authors.forename: Aiyou
authors.initials: A
authors.lastname: Hao
authors.affiliation: Qianfoshan Hospital Affiliated to Shandong University, Jinan 250018, PR China.
authors.forename: Guangcun
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Yimeng
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D002166:Camptothecin / Q000737:chemistry* / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D008567:Membranes, Artificial; D014867:Water / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D008567:Membranes, Artificial; D047392:beta-Cyclodextrins; D014867:Water; D002166:Camptothecin; D004121:Dimethyl Sulfoxide
keywords: Anticancer activity; Camptothecin; Cyclodextrin; Drug release; Vesicles