title: Role of SRC family kinases in prolactin signaling.
abstract: Prolactin (PRL) is a polypeptide hormone/cytokine mainly synthesized by the lactotrophic cells of the adenohypophysis. In addition to the best-known role in mammary gland development and the functional differentiation of its epithelium, PRL is involved in regulation of multiple physiological processes in higher organisms contributing to their homeostasis. PRL has been also associated with pathology, including breast cancer. Therefore, it is relevant to determine the molecular mechanisms by which PRL controls cellular functions. Here, we analyze the role of Src family kinases (SFKs) in the intracellular signaling pathways controlled by PRL in several model systems. The data show that SFKs are essential components in transmitting signals upon PRL receptor stimulation, as they control activation of Jak2/Stat5 and other routes that regulate PRL cellular responses.
authors.affiliation: Department of Cancer Biology, Instituto de Investigaciones Biomédicas A. Sols (CSIC/UAM), Arturo Duperier 4, 28029, Madrid, Spain, jmartin@iib.uam.es.
authors.forename: Jorge
authors.initials: J
authors.lastname: Martín-Pérez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: García-Martínez
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Sánchez-Bailón
authors.forename: Víctor
authors.initials: V
authors.lastname: Mayoral-Varo
authors.forename: Annarica
authors.initials: A
authors.lastname: Calcabrini
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004789:Enzyme Activation; D006801:Humans; D053614:Janus Kinase 2 / Q000378:metabolism; D053612:Janus Kinases / Q000502:physiology; D011388:Prolactin / Q000378:metabolism* / Q000494:pharmacology; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000502:physiology; D011981:Receptors, Prolactin / Q000502:physiology; D015398:Signal Transduction; D019061:src-Family Kinases / Q000502:physiology*
chemical_list: D011981:Receptors, Prolactin; D011388:Prolactin; D053614:Janus Kinase 2; D053612:Janus Kinases; D019061:src-Family Kinases; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11