title: Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?
abstract: High-risk human papillomaviruses (HR-HPV) are an established etiologic factor for a growing number of oropharyngeal cancers. However, their potential role in other upper aerodigestive tract locations is still a matter of debate, particularly in the oral cavity. This is of paramount importance as in the future diagnosis, treatment and follow up in head and neck squamous cell carcinoma may vary according to HPV status. This article reviews the recent published data and highlights some of the pitfalls that have hampered the accurate assessment of HR-HPV oncological role outside the oropharynx. We demonstrate that, in contrast to the oropharynx, only a small fraction of cancers located in the oral cavity seem to be HPV-related even in young non-smoking non-drinking patients. We emphasize several relevant factors to consider in assumed HPV-induced oral cavity cancers and discuss the current theories that explain why HPV-induced cancers arise preferentially in the oropharynx.
authors.affiliation: Department of Head and Neck Surgery, Institut de Cancérologie Gustave Roussy, Villejuif, France. Electronic address: mirghani_fr@yahoo.fr.
authors.forename: H
authors.initials: H
authors.lastname: Mirghani
authors.affiliation: Department of Otolaryngology, Peterborough City Hospital and Addenbrooke's Hospital, Cambridge, UK. Electronic address: furratamen@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Amen
authors.affiliation: Department of Virology, Faculty of Medicine-Pierre et Marie Curie University-Paris VI and Tenon Hospital, Assistance Publique Hôpitaux de Paris, France. Electronic address: frederiquemoreau@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Moreau
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine-Pierre et Marie Curie University-Paris VI and Tenon Hospital, Assistance Publique Hôpitaux de Paris, France. Electronic address: jean.lacau@tnn.aphp.fr.
authors.forename: J
authors.initials: J
authors.lastname: Lacau St Guily
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000821:virology*; D006801:Humans; D009062:Mouth Neoplasms / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000821:virology*; D012307:Risk Factors
keywords: HPV; Non-drinkers/non-smokers; Oral/oropharyngeal/oral cavity/head and neck cancer; Young patients