title: Interleukin-22 and rheumatoid arthritis: emerging role in pathogenesis and therapy.
abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and resultant progressive joint damage. It has become increasingly evident that cytokines play an important role in the pathogenesis of RA. Interleukin-22 (IL-22) is a member of the IL-10 cytokine family. Recent findings suggest that not only the expression of IL-22 is abnormal both in RA patients and in arthritis mice but also the aberrant IL-22 performs significantly in disease onset of RA. In this paper, we focus on the critical role of IL-22 in RA. Hopefully, the information obtained may lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for this systemic autoimmune disease.
authors.affiliation: School of Pharmacy, Anhui Medical University , Hefei, Anhui , PR China .
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D001323:Autoantibodies / Q000096:biosynthesis; D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D007596:Joints / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D015398:Signal Transduction; D000097043:Interleukin-22
chemical_list: D001323:Autoantibodies; D016753:Interleukin-10; D007378:Interleukins; D000097043:Interleukin-22; C508609:IL10 protein, human
keywords: Autoimmune; cytokine; inflammation; interleukin-22; rheumatoid arthritis