title: Serum inflammatory factor and cytokines in AECOPD.
abstract: OBJECTIVE
  To explore the serum levels of IL-32, MMP-9,PCT and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
  
  
  METHODS
  A total of 50 patients with AECOPD and 45 cases with acute asthma attack admitted from October 2013 to August 2014 were selected, and the serum levels of IL-32, MMP-9, PCT and CRP were determined and compaed by using Double antibody sandwich Enzyme linked immunosorbent assay, immunofluorescence double antibody sandwich assay and immunoturbidimetry assay.
  
  
  RESULTS
  Serum levels of IL-32, MMP-9, PCT and CRP were significantly higher in AECOPD group than acute asthma attack group (P<0.05). IL-32 and MMP-9 were negatively correlated with lung function. MMP-9 in AECOPD patients was increased more significantly.
  
  
  CONCLUSIONS
  Serum levels of IL-32 and MMP-9 were negatively correlated with lung function, and the worse the lung function is, the more significant the increase is.
authors.affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075061, China.
authors.forename: Tie-Gang
authors.initials: TG
authors.lastname: Jia
authors.affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075061, China. Electronic address: jq.zhao66@163.com.
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Zhao
authors.affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075061, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
keywords: AECOPD; AHTMA; CRP; IL-32; MMP-9; PCT; PF; Serum