title: Investigation of the impact of increased dietary insoluble fiber through the feeding of distillers dried grains with solubles (DDGS) on the incidence and severity of Brachyspira-associated colitis in pigs.
abstract: Diet has been implicated as a major factor impacting clinical disease expression of swine dysentery and Brachyspira hyodysenteriae colonization. However, the impact of diet on novel pathogenic strongly beta-hemolytic Brachyspira spp. including "B. hampsonii" has yet to be investigated. In recent years, distillers dried grains with solubles (DDGS), a source of insoluble dietary fiber, has been increasingly included in diets of swine. A randomized complete block experiment was used to examine the effect of increased dietary fiber through the feeding of DDGS on the incidence of Brachyspira-associated colitis in pigs. One hundred 4-week-old pigs were divided into five groups based upon inocula (negative control, Brachyspira intermedia, Brachyspira pilosicoli, B. hyodysenteriae or "B. hampsonii") and fed one of two diets containing no (diet 1) or 30% (diet 2) DDGS. The average days to first positive culture and days post inoculation to the onset of clinical dysentery in the B. hyodysenteriae groups was significantly shorter for diet 2 when compared to diet 1 (P = 0.04 and P = 0.0009, respectively). A similar difference in the average days to first positive culture and days post inoculation to the onset of clinical dysentery was found when comparing the "B. hampsonii" groups. In this study, pigs receiving 30% DDGS shed on average one day prior to and developed swine dysentery nearly twice as fast as pigs receiving 0% DDGS. Accordingly, these data suggest a reduction in insoluble fiber through reducing or eliminating DDGS in swine rations should be considered an integral part of any effective disease elimination strategy for swine dysentery.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Bailey L
authors.initials: BL
authors.lastname: Wilberts
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Arruda
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Joann M
authors.initials: JM
authors.lastname: Kinyon
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Frana
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Drew R
authors.initials: DR
authors.lastname: Magstadt
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Darin M
authors.initials: DM
authors.lastname: Madson
authors.affiliation: Department of Animal Science, Iowa State University, 201H Kildee, Ames, Iowa, 50011, United States of America.
authors.forename: John F
authors.initials: JF
authors.lastname: Patience
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1600 S. 16th St, Ames, Iowa, 50011, United States of America.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Burrough
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D017400:Brachyspira / Q000472:pathogenicity*; D003092:Colitis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D004043:Dietary Fiber / Q000009:adverse effects*; D004403:Dysentery / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D002523:Edible Grain / Q000009:adverse effects*; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000382:microbiology; D015994:Incidence; D008297:Male; D012720:Severity of Illness Index; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology