title: Ligand Design for Rh(III)-Catalyzed C-H Activation: An Unsymmetrical Cyclopentadienyl Enables a Regioselective Synthesis of Dihydroisoquinolones.
abstract: We report the regioselective synthesis of dihydroisoquinolones from aliphatic alkenes andO-pivaloyl benzhydroxamic acids mediated by a Rh(III) precatalyst bearing sterically bulky substituents. While the prototypical Cp* ligand provides product with low selectivity, sterically bulky Cptaffords product with excellent regioselectivity for a range of benzhydroxamic acids and alkenes. Crystallographic evidence offers insight as to the source of the increased regioselectivity.
authors.affiliation: Department of Chemistry Colorado State University Fort Collins, Colorado 80523 USA.
authors.forename: Todd K
authors.initials: TK
authors.lastname: Hyster
authors.affiliation: Department of Chemistry Colorado State University Fort Collins, Colorado 80523 USA.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Dalton
authors.affiliation: Department of Chemistry Colorado State University Fort Collins, Colorado 80523 USA.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Rovis