title: Experimental study of pharmacokinetics of external, whole-body bathing application of ivermectin.
abstract: As a novel method improving the safety of conventional oral ivermectin (IVM) for scabies treatment, we conceived an idea called the "whole-body bathing method". In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. To evaluate the feasibility of the method, we investigated the IVM concentration in the skin and plasma after bathing rats in a fluid containing 100 ng/mL of IVM. After the bathing, the concentration of IVM in the skin was more than 400 ng/g wet weight and was maintained until 8 h after the bathing. The concentration was clearly higher than that in patients taking IVM p.o. as previously reported; IVM was not detected in plasma in the present study. Thus, the method would be a preferable drug delivery system for the skin application of IVM compared with p.o. administration.
authors.affiliation: Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyajima
authors.forename: Masayo
authors.initials: M
authors.lastname: Komoda
authors.forename: Keita
authors.initials: K
authors.lastname: Akagi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yuzawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirota
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007559:Ivermectin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D017208:Rats, Wistar; D012532:Scabies / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin
keywords: bathing; ivermectin; rats; scabies; skin