title: Implementation and performance of the BioFire FilmArray® Blood Culture Identification panel with antimicrobial treatment recommendations for bloodstream infections at a midwestern academic tertiary hospital.
abstract: The FilmArray® Blood Culture Identification (BCID) panel was recently implemented at a midwestern academic tertiary care hospital to provide rapid identification (ID) of common pathogens from positive blood cultures. This study evaluated the clinical performance of the BCID panel compared to culture-based ID methods. One hundred thirty-eight monomicrobial and 8 polymicrobial blood cultures were evaluated during the 30-day study resulting in the ID of 152 total organisms by culture with 115 organisms correctly identified using the BCID panel. The BCID panel had sensitivities of 80.4% (115/152) for all organisms identified during the study and 94.6% (115/122) when considering only on-panel organisms. BCID panel specificity was 100%. Implementation of the BCID panel was coupled with the development of empiric therapy recommendations for bloodstream infections by the antimicrobial stewardship team. Based on this study, the FilmArray® BCID panel is a rapid and reliable test for the detection of common bloodstream pathogens, and therapeutic decisions can be based upon panel results.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA. Electronic address: robbie.southern@unmc.edu.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Southern
authors.affiliation: Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Trevor C
authors.initials: TC
authors.lastname: VanSchooneveld
authors.affiliation: Clinical Microbiology Laboratory, The Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Dianna L
authors.initials: DL
authors.lastname: Bannister
authors.affiliation: Clinical Microbiology Laboratory, The Nebraska Medical Center, Omaha, NE, USA.
authors.forename: TeAnne L
authors.initials: TL
authors.lastname: Brown
authors.affiliation: Clinical Microbiology Laboratory, The Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Crismon
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA.
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Buss
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Iwen
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Fey
mesh_terms: D000046:Academic Medical Centers; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis* / Q000188:drug therapy*; D001419:Bacteria / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D001769:Blood / Q000382:microbiology*; D006801:Humans; D012680:Sensitivity and Specificity; D062606:Tertiary Care Centers
chemical_list: D000890:Anti-Infective Agents
keywords: Antimicrobial recommendations; Antimicrobial stewardship; BCID; Bloodstream infection; Clinical performance; FilmArray Blood Culture Identification panel