title: Investigation of the functional single-nucleotide polymorphisms in theBCRPtransporter and susceptibility to colorectal cancer.
abstract: Breast cancer resistance protein (BCRP) protects tissues by actively transporting xenobiotics and their metabolites out of the cells.BCRPis expressed in the apical membrane of normal intestinal and colonic epithelium. TheBCRPsubstrates include a number of structurally unrelated compounds, such as drugs, pesticides, carcinogens and endogenous compounds. Although the functional and commonBCRPalleles, 34G>A and 421C>A, are shown to vary by ethnicity, their potential mechanism has not been adequately described with regards to affecting the susceptibility to colorectal cancer. The present study aimed to evaluate the effects of theBCRPvariants on the susceptibility to colorectal cancer and to predict the individual responses to xenobiotics transferred byBCRP.BCRP421C>A was significantly associated with the colorectal cancer risk (odds ratio, 16.12; P=0.005). These findings are the first results ofBCRPallele distributions in the Turkish population and provide an understanding of the correlation between therapeutic approaches and etiology of colorectal cancer.
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey.
authors.forename: Fatih M
authors.initials: FM
authors.lastname: Sari
authors.affiliation: Department of General Surgery, Faculty of Medicine, Istanbul University, Istanbul 34390, Turkey.
authors.forename: Hakan T
authors.initials: HT
authors.lastname: Yanar
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey.
authors.forename: Gul
authors.initials: G
authors.lastname: Ozhan
keywords: BCRP variants; colorectal cancer; genetic polymorphisms