title: Diffusion Tensor Imaging (DTI) findings following pediatric non-penetrating TBI: a meta-analysis.
abstract: This study meta-analyzed research examining Diffusion Tensor Imaging following pediatric non-penetrating traumatic brain injury to identify the location and extent of white matter changes. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) data from 20 studies were analyzed. FA increased and ADC decreased in most white matter tracts in the short-term (moderate-to-large effects), and FA decreased and ADC increased in the medium- to long-term (moderate-to-very-large effects). Whole brain (short-term), cerebellum and corpus callosum (medium- to long-term) FA values have diagnostic potential, but the impact of age/developmental stage and injury severity on FA/ADC, and the predictive value, is unclear.
authors.affiliation: a School of Psychology , University of Adelaide , Adelaide , Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: Roberts
authors.forename: J L
authors.initials: JL
authors.lastname: Mathias
authors.forename: S E
authors.initials: SE
authors.lastname: Rose
mesh_terms: D016880:Anisotropy; D001930:Brain Injuries / Q000175:diagnosis*; D002648:Child; D003337:Corpus Callosum; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D015599:Trauma Severity Indices; D014949:Wounds, Nonpenetrating / Q000175:diagnosis*