title: Severe, but manageable hypoxia caused by bronchospasm induced by bevacizumab.
abstract: Bevacizumab has a lower risk of treatment-related infusion reactions than other humanized monoclonal antibodies, and bronchospasm induced by bevacizumab has not been reported. We administered bevacizumab 15 mg/kg over 90 min infusion to a 34 year-old man with lung adenocarcinoma and childhood asthma. Then, grade 3 hypoxia developed and improved spontaneously. This reversible obstructive lung disorder was confirmed using a flow-volume loop, and the patient was diagnosed as having a bronchospasm due to infusion reaction of bevacizumab. This bronchospasm was easily manageable and preventable using an oral bronchodilator and an inhalant combination product, and the patient continued with bevacizumab therapy until the disease progression.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan ; Sasebo City General Hospital Sasebo, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsuchida
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Motoshima
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Mizoguchi
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine Nagasaki, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
keywords: bevacizumab; bronchospasm; infusion reaction; non-small cell lung cancer