title: Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity.
abstract: This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Dawei
authors.initials: D
authors.lastname: Xu
authors.forename: Linhai
authors.initials: L
authors.lastname: Jiang
authors.forename: Anju
authors.initials: A
authors.lastname: Singh
authors.forename: Derek
authors.initials: D
authors.lastname: Dustin
authors.forename: Miao
authors.initials: M
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Reidar
authors.initials: R
authors.lastname: Lund
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Sellati
authors.forename: He
authors.initials: H
authors.lastname: Dong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D001854:Bone Marrow Cells / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D051379:Mice; D008958:Models, Molecular; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D049329:Nanostructures; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D011487:Protein Conformation
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides