title: The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors.
abstract: BACKGROUND
  The aims of this study were to investigate the immunolocalization of ezrin and its relationship with the podoplanin expression in keratocystic odontogenic tumors.
  
  
  METHODS
  The immunohistochemical expressions of ezrin and podoplanin by odontogenic epithelium were evaluated in keratocystic odontogenic tumors using monoclonal antibodies.
  
  
  RESULTS
  Our results showed strong cytoplasmic ezrin and membranous podoplanin expressions in basal epithelial layer of all keratocystic odontogenic tumors. The cytoplasmic and membranous ezrin expressions were also detected in suprabasal epithelial layers of tumors. Statistically significant difference between cellular immunolocalization of ezrin and podoplanin odontogenic epithelium were found by Wilcoxon's test (p < 0.05). No correlation between both proteins in keratocystic odontogenic tumors was detected by Spearman test.
  
  
  CONCLUSIONS
  These results suggest that ezrin and podoplanin may contribute to the expansive growth and local invasiveness of keratocystic odontogenic tumors. Additionally, as both proteins were overexpressed by odontogenic epithelium, their possible roles need to be further explored in benign odontogenic tumors.
authors.affiliation: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, 17012-901 Bauru, São Paulo, Brazil. denisetostes@usp.br.
authors.forename: Denise Tostes
authors.initials: DT
authors.lastname: Oliveira
authors.forename: Laís Priscila
authors.initials: LP
authors.lastname: de Santis
authors.forename: Agnes
authors.initials: A
authors.lastname: Assao
authors.forename: Kellen Cristine
authors.initials: KC
authors.lastname: Tjioe
authors.forename: Suely
authors.initials: S
authors.lastname: Nonogaki
authors.forename: José Roberto Pereira
authors.initials: JR
authors.lastname: Lauris
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Soares
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002462:Cell Membrane / Q000737:chemistry; D002648:Child; D003593:Cytoplasm / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000032:analysis*; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000473:pathology; D008441:Maxillary Neoplasms / Q000737:chemistry / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000737:chemistry* / Q000473:pathology; D055815:Young Adult; D000099149:Ezrin; D000098853:Podoplanin
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D008562:Membrane Glycoproteins; D000099149:Ezrin; C117468:PDPN protein, human; D000098853:Podoplanin