title: Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
abstract: The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model. Twenty-eight male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). Three weeks after induction of diabetes, mice were divided randomly into 4 groups in which each group contained 7 mice; fisetin-treated group (group 1), α-lipoic acid-treated group (group 2), fisetin placebo group (group 3), α-lipoic acid placebo group (group 4). Fisetin and α-lipoic acid were administered intraperitoneally weekly for 5 weeks. Cataract development was assessed at the end of 8 weeks by slit lamp examination, and cataract formation was graded using a scale. All groups developed at least grade 1 cataract formation. In the fisetin-treated group, the cataract stages were significantly lower than in the placebo group (p = 0.02). In the α-lipoic acid-treated group, the cataract stages were lower than in the placebo group but it did not reach to a significant value. Both fisetin and α-lipoic acid had a protective effect on cataract development in a streptozotocin-induced experimental cataract model. The protective effect of fisetin appears as though more effective than α-lipoic acid.
authors.affiliation: Department of Ophthalmology, Samsun Training and Research Hospital, Samsun, Turkey. dremrahkan@yahoo.com.
authors.forename: Emrah
authors.initials: E
authors.lastname: Kan
authors.affiliation: Department of Endocrinology and Metabolism, Samsun Training and Research Hospital, Samsun, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Kiliçkan
authors.affiliation: Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ayar
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Ramis
authors.initials: R
authors.lastname: Çolak
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D002386:Cataract / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D048909:Diabetes Complications / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000008:administration & dosage*; D044948:Flavonols; D007908:Lens, Crystalline / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008063:Thioctic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; D008063:Thioctic Acid; C017875:fisetin
keywords: Antioxidants; Diabetic cataract; Experimental cataract; Fisetin; α-Lipoic acid