title: Investigating the Turing conditions for diffusion-driven instability in the presence of a binding immobile substrate.
abstract: Turing's diffusion-driven instability for the standard two species reaction-diffusion system is only achievable under well-known and rather restrictive conditions on both the diffusion rates and the kinetic parameters, which necessitates the pairing of a self-activator with a self-inhibitor. In this study we generalize the standard two-species model by considering the case where the reactants can bind to an immobile substrate, for instance extra-cellular matrix, and investigate the influence of this dynamics on Turing's diffusion-driven instability. Such systems have been previously studied on the grounds that binding of the self-activator to a substrate may effectively reduce its diffusion rate and thus induce a Turing instability for species with equal diffusion coefficients, as originally demonstrated by Lengyel and Epstein (1992) under the assumption that the bound state dynamics occurs on a fast timescale. We, however, analyse the full system without any separation of timescales and demonstrate that the full system also allows a relaxation of the standard constraints on the reaction kinetics for the Turing instability, increasing the type of interactions that could give rise to spatial patterning. In particular, we show that two self-activators can undertake a diffusively driven instability in the presence of a binding immobile substrate, highlighting that the interactions required of a putative biological Turing instability need not be associated with a self-activator-self-inhibitor morphogen pair.
authors.affiliation: Department of Mathematics, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Trojanova 13, 120 00 Prague 2, Czech Republic. Electronic address: k.korvasova@fz-juelich.de.
authors.forename: K
authors.initials: K
authors.lastname: Korvasová
authors.affiliation: Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, OX2 6GG Oxford, United Kingdom. Electronic address: gaffney@maths.ox.ac.uk.
authors.forename: E A
authors.initials: EA
authors.lastname: Gaffney
authors.affiliation: Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, OX2 6GG Oxford, United Kingdom. Electronic address: maini@maths.ox.ac.uk.
authors.forename: P K
authors.initials: PK
authors.lastname: Maini
authors.affiliation: Department of Mathematics, Faculty of Science and Technology, University of Coimbra, P.O. Box 3008, 3001-501 Coimbra, Portugal. Electronic address: marfafe@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Ferreira
authors.affiliation: Department of Mathematics, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Trojanova 13, 120 00 Prague 2, Czech Republic; Institute of Thermomechanics, Academy of Sciences of the Czech Republic, Dolejskova 5, 182 00 Prague 8, Czech Republic. Electronic address: klika@it.cas.cz.
authors.forename: V
authors.initials: V
authors.lastname: Klika
mesh_terms: D004058:Diffusion; D007700:Kinetics; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D013379:Substrate Specificity
keywords: Morphogen; Non-diffusive substrate; Pattern formation; Turing instability