title: Effects of amphiphilic chitosan-g-poly(ε-caprolactone) polymer additives on paclitaxel release from drug eluting implants.
abstract: Bioresorbable polymer stents have been proposed as promising medical implants to avoid long-term safety concerns and other potential issues caused by traditional materials. As an important member, poly(ε-caprolactone) (PCL) was used as the implant matrix with different drug loadings. To better regulate drug release rate, the hydrophilicity of PCL was adjusted by addition of amphiphilic graft copolymers, chitosan-g-poly(ε-caprolactone) (CP). The in vitro release results indicated that the improvement of bulk hydrophilicity could accelerate drug release better than that of surface coating. The optimum additive amount was 25% with CP9. Further study showed that the effect of aspirin molecules displayed no obvious difference to that of CP macromolecules on drug release rate. Moreover, these release profiles were fitted with mathematical models. The similarities were evaluated with similarity factors. Scanning electron microscopy (SEM) images displayed surface/cross-section morphologies of pure PCL and modified implants before and after release.
authors.affiliation: Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
authors.forename: Weibin
authors.initials: W
authors.lastname: Shi
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Gu
authors.affiliation: Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
authors.forename: Han
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Mengru
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: mdlang@ecust.edu.cn.
authors.forename: Meidong
authors.initials: M
authors.lastname: Lang
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004343:Drug Implants / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000032:analysis / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D015607:Stents; D013499:Surface Properties
chemical_list: D004343:Drug Implants; D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan; D017239:Paclitaxel
keywords: Drug release; Graft copolymer; Paclitaxel; Poly(ε-caprolactone)