title: DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression.
abstract: Viruses use various mechanisms to evade clearance by the host. Investigating how a few changes in the genome of a non-lethal virus can lead to altered disease, from survivable to immunosuppression/death, would provide valuable information into viral pathogenesis. The Daniels strain of Theiler's murine encephalomyelitis virus causes an asymptomatic infection or acute encephalitis followed by viral clearance. A mutant, H101, carries several alterations in the viral genome. H101 infection causes profound immunosuppression and death. Thus, a virus that is normally cleared by its natural host can become lethal due to just a few changes in the viral genome.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, United States.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Cusick
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, United States.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, United States.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Doty
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, United States. Electronic address: Robert.Fujinami@hsc.utah.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D018188:Cardiovirus Infections / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation / Q000235:genetics*; D018991:Myelin Proteolipid Protein / Q000276:immunology / Q000633:toxicity; D010446:Peptide Fragments / Q000276:immunology / Q000633:toxicity; D010798:Phycocyanin / Q000378:metabolism; D013154:Spleen / Q000473:pathology; D017945:Theilovirus / Q000235:genetics* / Q000472:pathogenicity*; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments; C002497:allophycocyanin; C435023:myelin proteolipid protein (139-151); D010798:Phycocyanin; D003208:Concanavalin A; D005620:Freund's Adjuvant
keywords: Immunosuppression; Picornavirus; T cell; Viral pathogenesis