title: Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies.
abstract: We report the synthesis of a novel, water-soluble aryl-extended calix[4]pyrrole receptor. The water-solubilising groups are placed at the lower rim of the receptor, leaving the binding pocket unperturbed and open for modification. Binding studies were performed with a series of pyridine N-oxides. These studies revealed the ability of the receptor to bind neutral and charged N-oxides in basified water with stability constants higher than 10(4) M(-1).
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16. E-43007, Tarragona, Spain. pballester@iciq.es.
authors.forename: D
authors.initials: D
authors.lastname: Hernández-Alonso
authors.forename: S
authors.initials: S
authors.lastname: Zankowski
authors.forename: L
authors.initials: L
authors.lastname: Adriaenssens
authors.forename: P
authors.initials: P
authors.lastname: Ballester