title: [Impact of androgen therapy on metabolic and inflammatory profiles in male hypogonadism].
abstract: This study aims to evaluate the impact of androgen therapy on metabolic and inflammatoy profiles in male hypogonadic patients. Forty cases with isolated hypogonadism and 80 controls were enrolled. Clinical data were collected (age, weight, height, waist circonference and androgenothearapy). Blood tests were performed to evaluate testosterone, homeostasis index modal assessment (HOMA-IR), lipids and C reactive protein (CRP). Among hypogonadic patients, 14 of them were treated for 4 +/- 3.4 years. Amongst them testosterone levels were significantly elevated comparatively to non-treated patients and significantly lower than controls. Significant differences were noted on waist circumference between non treated patients and controls. Body mass index and HOMA-IR were significantly higher in non-treated patients. Triglycerides and HDLc were significantly decreased respectively in treated and non-treated patients. However, CRP levels were significantly decreased in controls. In conclusion, androgen therapy appeared to protect against obesity, insulin resistance, and hyperlipidemia. Effects on systemic inflammation seemed to be more discrete. Testosterone substitution should be strongly indicated in daily practice with careful prostate monitoring.
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Khansa
authors.initials: K
authors.lastname: Chaabouni
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Manel
authors.initials: M
authors.lastname: Naifar
authors.affiliation: Service d'endocrinologie diabétologie, Centre hospitalo-universitaire H. Chaker, Sfax, Tunisie.
authors.forename: Nabila
authors.initials: N
authors.lastname: Mejdoub
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Amina
authors.initials: A
authors.lastname: Lahyani
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Mariem
authors.initials: M
authors.lastname: Messedi
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Aida
authors.initials: A
authors.lastname: Elleuch
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Mouna
authors.initials: M
authors.lastname: Turki
authors.affiliation: Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Kamel
authors.initials: K
authors.lastname: Jamoussi
authors.affiliation: Service d'endocrinologie diabétologie, Centre hospitalo-universitaire H. Chaker, Sfax, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abid
authors.affiliation: Laboratoire de biochimie, Centre hospitalo-universitaire H. Bourguiba, Sfax, Tunisie, Unité de recherche bases moléculaires de la pathologie humaine, Faculté de médecine, Sfax, Tunisie.
authors.forename: Fatma
authors.initials: F
authors.lastname: Ayedi
mesh_terms: D000328:Adult; D000728:Androgens / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000728:Androgens; D007328:Insulin; D008055:Lipids; D013739:Testosterone; D002097:C-Reactive Protein
keywords: androgen therapy; body mass index; insulin sensitivity; lipids