title: Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.
abstract: We examined the protective effect of pogostone (PO), a chemical constituent isolated from Pogostemonis Herba, on the ethanol-induced gastric ulcer in rats. Administration of PO at doses of 10, 20 and 40 mg/kg body weight prior to ethanol ingestion effectively protected the stomach from ulceration. The gastric lesions were significantly ameliorated by all doses of PO as compared to the vehicle group. Pre-treatment with PO prevented the oxidative damage and the decrease of prostaglandin E2 (PGE2) content. In addition, PO pretreatment markedly increased the mucosa levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), and decreased gastric malonaldehyde (MDA), relative to the vehicle group. In the mechanistic study, significant elevation of non-protein-sulfhydryl (NP-SH) was observed in the gastric mucosa pretreated by PO. Analysis of serum cytokines indicated that PO pretreatment obviously elevated the decrease of interleukin-10 (IL-10) level, while markedly mitigated the increment of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) secretions in ethanol-induced rats. Taken together, these results strongly indicate that PO could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH.
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Liao
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China; Faculty of Health Sciences, University of Macau, Macau 999078, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
authors.forename: Zuqing
authors.initials: Z
authors.lastname: Su
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
authors.forename: Xie
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Zhengquan
authors.initials: Z
authors.lastname: Lai
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China; Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, People's Republic of China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lai
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: linzx@cuhk.edu.hk.
authors.forename: Zhi-Xiu
authors.initials: ZX
authors.lastname: Lin
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China; Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, People's Republic of China. Electronic address: suziren@gzucm.edu.cn.
authors.forename: Ziren
authors.initials: Z
authors.lastname: Su
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects; D005753:Gastric Mucosa / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019686:Lamiaceae / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009822:Oils, Volatile / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D009822:Oils, Volatile; C483658:Pogostone; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000431:Ethanol; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D015232:Dinoprostone
keywords: Anti-inflammatory; Antioxidant; Ethanol; Gastric ulcer; Pogostone; Rats