title: Enteroendocrine MC4R and energy balance: linking the long and the short of it.
abstract: Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance. In this issue, Panaro et al. (2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.
authors.affiliation: Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; School of Medicine, University College Cork, Cork, Ireland.
authors.forename: Sean
authors.initials: S
authors.lastname: Manning
authors.affiliation: Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK. Electronic address: r.batterham@ucl.ac.uk.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Batterham
mesh_terms: D000818:Animals; D019858:Enteroendocrine Cells / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D019894:Peptide YY / Q000378:metabolism*; D044105:Receptor, Melanocortin, Type 4 / Q000378:metabolism*
chemical_list: D044105:Receptor, Melanocortin, Type 4; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1