title: 3D velocity field and flow profile reconstruction from arbitrarily sampled Doppler ultrasound data.
abstract: With the need for adequate analysis of blood flow dynamics, different maging modalities have been developed to measure varying blood velocities over time. Due to its numerous advantages, Doppler ultrasound sonography remains one of the most widely used techniques in clinical routine, but requires additional preprocessing to recover 3D velocity information. Despite great progress in the last years, recent approaches do not jointly consider spatial and temporal variation in blood flow. In this work, we present a novel gating- and compounding-free method to simultaneously reconstruct a 3D velocity field and a temporal flow profile from arbitrarily sampled Doppler ultrasound measurements obtained from multiple directions. Based on a laminar flow assumption, a patch-wise B-spline formulation of blood velocity is coupled for the first time with a global waveform model acting as temporal regularization. We evaluated our method on three virtual phantom datasets, demonstrating robustness in terms of noise, angle between measurements and data sparsity, and applied it successfully to five real case datasets of carotid artery examination.
authors.forename: Oliver
authors.initials: O
authors.lastname: Zettinig
authors.forename: Christoph
authors.initials: C
authors.lastname: Hennersperger
authors.forename: Christian
authors.initials: C
authors.lastname: Schulte Zu Berge
authors.forename: Maximilian
authors.initials: M
authors.lastname: Baust
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000502:physiology*; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted