title: Ebola virus (EBOV) infection: Therapeutic strategies.
abstract: Within less than a year after its epidemic started (in December 2013) in Guinea, Ebola virus (EBOV), a member of the filoviridae, has spread over a number of West-African countries (Guinea, Sierra Leone and Liberia) and gained allures that have been unprecedented except by human immunodeficiency virus (HIV). Although EBOV is highly contagious and transmitted by direct contact with body fluids, it could be counteracted by the adequate chemoprophylactic and -therapeutic interventions: vaccines, antibodies, siRNAs (small interfering RNAs), interferons and chemical substances, i.e. neplanocin A derivatives (i.e. 3-deazaneplanocin A), BCX4430, favipiravir (T-705), endoplasmic reticulum (ER) α-glucosidase inhibitors and a variety of compounds that have been found to inhibit EBOV infection blocking viral entry or by a mode of action that still has to be resolved. Much has to be learned from the mechanism of action of the compounds active against VSV (vesicular stomatitis virus), a virus belonging to the rhabdoviridae, that in its mode of replication could be exemplary for the replication of filoviridae.
authors.affiliation: Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Electronic address: erik.declercq@rega.kuleuven.be.
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000354:Africa, Western / Q000453:epidemiology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D029043:Ebolavirus / Q000187:drug effects* / Q000502:physiology; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission*; D006801:Humans
chemical_list: D000998:Antiviral Agents
keywords: 3-Deazaneplanocin A; 3-Deazaneplanocin A (PubChem CID: 73087); Amiodarone (PubChem CID: 2157); BCX-1777 (PubChem CID: 11493192); BCX4430; BCX4430 (PubChem CID: 69211190); Chloroquine (PubChem CID: 2719); Clomifene (PubChem CID: 1548953); Dronedarone (PubChem CID: 208898); Ebola; FGI-103 (PubChem CID: 5477931); Favipiravir; Favipiravir (PubChem CID: 492405); Filoviridae; LJ 001 (PubChem CID: 49777349); NSC62914 (PubChem CID: 66662); VSV (vesicular stomatitis virus); Verapamil (PubChem CID: 2520); dUY11 (PubChem CID: 24771429)