title: Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child.
abstract: BACKGROUND
  Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed.
  
  
  METHODS
  Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers.
  
  
  CONCLUSIONS
  Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
authors.affiliation: Department of Pharmacology, Masaryk University School of Medicine, Brno, Czech Republic. ; Regional Center for Applied Molecular Oncology, Brno, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Demlova
authors.affiliation: Department of Pediatric Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Melicharkova
authors.affiliation: Department of Nuclear Medicine, Masaryk Memorial Cancer Institute, Brno, Czech Republic. ; Regional Center for Applied Molecular Oncology, Brno, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Rehak
authors.affiliation: Department of Pathology, University Hospital Brno, Brno, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Kren
authors.affiliation: Department of Pediatric Neurology, University Hospital Brno, Brno, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Oslejskova
authors.affiliation: Regional Center for Applied Molecular Oncology, Brno, Czech Republic. ; Department of Pediatric Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Sterba
keywords: Metronomic chemotherapy; biomarkers; pediatric glioma; pet imaging; vinblastine