title: Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle.
abstract: Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼ 3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼-25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.
authors.affiliation: School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Walsh
authors.forename: Brittany A
authors.initials: BA
authors.lastname: Edgett
authors.forename: Michael E
authors.initials: ME
authors.lastname: Tschakovsky
authors.forename: Brendon J
authors.initials: BJ
authors.lastname: Gurd
mesh_terms: D000328:Adult; D001642:Bicycling; D019208:Brain-Derived Neurotrophic Factor / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D018592:Cross-Over Studies; D015444:Exercise; D005215:Fasting / Q000009:adverse effects*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D010101:Oxygen Consumption; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D005082:Physical Exertion; D052097:Quadriceps Muscle / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*; D013312:Stress, Physiological; D014157:Transcription Factors / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger; D014157:Transcription Factors; C579455:BDNF protein, human
keywords: PGC-1α; energetic stress; exercice par intervalle d’intensité élevée; high-intensity interval exercise; stress énergétique