title: Nuclear envelope lamin-A as a coordinator of T cell activation.
abstract: Nuclear lamins A/C control several critical cellular functions, e.g., chromatin organization, gene transcription, DNA replication, DNA damage responses, cell cycle progression, cell differentiation, and cell polarization during migration. However, few studies have addressed the role of lamins A/C in the control of the functions of immune cells. Recently, we have demonstrated that lamins A/C are induced in T cells upon antigen recognition. Lamins A/C enhance T cell responses by coupling the plasma membrane to the nucleus via the linker of nucleoskeleton and cytoskeleton (LINC) complex and the actin cytoskeleton. Here, we discuss the possible physiological relevance and functional context of lamin A/C in T cell activation and propose a model in which lamins A/C are key modulators of immune cell functions.
authors.affiliation: a Servicio de Inmunología; Hospital Universitario de la Princesa; Instituto de Investigación Sanitaria de la Princesa; Madrid, Spain.
authors.forename: Vera
authors.initials: V
authors.lastname: Rocha-Perugini
authors.forename: José M
authors.initials: JM
authors.lastname: González-Granado
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics / Q000276:immunology; D002843:Chromatin / Q000235:genetics; D006801:Humans; D007107:Immune System; D034904:Lamin Type A / Q000235:genetics* / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics* / Q000276:immunology; D009685:Nuclear Envelope / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D002843:Chromatin; D034904:Lamin Type A
keywords: T-cell activation; immune synapse; immune system; lamin A/C; nuclear envelope proteins