title: The antitumor action of cannabinoids on glioma tumorigenesis.
abstract: Cannabinoids are a class of chemical compounds with a wide spectrum of pharmacological effects, mediated by two specific plasma membrane receptors (CB1 and CB2). Recently, CB1 and CB2 expression levels have been detected in human tumors, including those of brain. Cannabinoids-endocannabinoids exert anti-inflammatory, anti-proliferative, anti-invasive, anti-metastatic and pro-apoptotic effects in different cancer types, both in vitro and in vivo in animal models, after local or systemic administration. We present the available experimental and clinical data, to date, regarding the antitumor action of cannabinoids on the tumorigenesis of gliomas.
authors.affiliation: First Department of Pathology, Medical School, University of Athens. p.zogopoulos@yahoo.com.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Zogopoulos
authors.affiliation: First Department of Pathology, Medical School, University of Athens.
authors.forename: Penelope
authors.initials: P
authors.lastname: Korkolopoulou
authors.affiliation: First Department of Pathology, Medical School, University of Athens.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.affiliation: First Department of Pathology, Medical School, University of Athens.
authors.forename: Stamatios
authors.initials: S
authors.lastname: Theocharis
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002186:Cannabinoids / Q000494:pharmacology* / Q000627:therapeutic use; D063646:Carcinogenesis / Q000187:drug effects* / Q000378:metabolism; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*
chemical_list: D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1