title: Metabolic syndrome in patients with myotonic dystrophy type 1.
abstract: BACKGROUND
  The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1).
  
  
  METHODS
  We studied 66 DM1 patients (50% men, aged 41.9 ± 10.5 years, disease duration of 19.3 ± 8.6 years). New worldwide consensus criteria for MetS from 2009 were used.
  
  
  RESULTS
  Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P > 0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P < 0.05).
  
  
  CONCLUSIONS
  Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.
authors.affiliation: Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Milorad
authors.initials: M
authors.lastname: Vujnic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
authors.forename: Stojan
authors.initials: S
authors.lastname: Peric
authors.affiliation: Endocrinology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Popovic
authors.affiliation: Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Nela
authors.initials: N
authors.lastname: Raseta
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Ralic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
authors.forename: Valerija
authors.initials: V
authors.lastname: Dobricic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Novakovic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
authors.forename: Vidosava
authors.initials: V
authors.lastname: Rakocevic-Stojanovic
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology
keywords: dyslipidemia; hypertension; metabolic syndrome; myotonic dystrophy type 1; obesity