title: A retrospective analysis of 111 canine prostatic samples: histopathological findings and classification.
abstract: The purpose of this retrospective study is to evaluate the frequency and further characterize the pathological features of common and uncommon histological lesions in 111 canine prostatic samples. Benign prostatic hyperplasia, suppurative and non-suppurative prostatitis, and prostate cancer were observed individually or in combination in 45, 11, 68 and 50 samples, respectively. Six growth patterns of prostatic carcinoma were differentiated: papillary, cribriform, solid, small acinar/ductal, signet ring, mucinous. In a few cases, perineurial invasion and collagenous micronodules were observed. Lesions considered preneoplastic in men, such as high-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic inflammatory atrophy (PIA), were observed in 27 and 21 histological samples, respectively. This study represents a detailed characterization of the different histological subtypes of canine prostate cancer. The awareness of the unusual patterns might be critical in avoiding diagnostic misinterpretation. The high prevalence of PIA and HGPIN underlines the reasonable chance of their detection in routine biopsy specimens.
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland 4343, Australia. Electronic address: c.palmieri@uq.edu.au.
authors.forename: C
authors.initials: C
authors.lastname: Palmieri
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland 4343, Australia.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Lean
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland 4343, Australia.
authors.forename: S H
authors.initials: SH
authors.lastname: Akter
authors.affiliation: Department of Veterinary Science and Public Health, Universita' degli Studi di Milano, via Celoria 10, Milan 20133, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Romussi
authors.affiliation: Department of Veterinary Science and Public Health, Universita' degli Studi di Milano, via Celoria 10, Milan 20133, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Grieco
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000145:classification* / Q000473:pathology*; D004285:Dogs; D006652:Histological Techniques / Q000662:veterinary; D008297:Male; D011470:Prostatic Hyperplasia / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D019048:Prostatic Intraepithelial Neoplasia / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies
keywords: Classification; Dog; Histology; Prostate