title: Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis.
abstract: OBJECTIVE
  To provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity.
  
  
  RESULTS
  It is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state.
  
  
  CONCLUSIONS
  Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-β may contribute to reducing adipose inflammation that may also provide renoprotection.
authors.affiliation: aCenter for Renal Translational Medicine, La Jolla, California, USA bLaboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium cInstitute for Metabolomic Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, La Jolla, California, USA.
authors.forename: Anne-Emilie
authors.initials: AE
authors.lastname: Declèves
authors.forename: Kumar
authors.initials: K
authors.lastname: Sharma
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005355:Fibrosis / Q000209:etiology / Q000378:metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007249:Inflammation / Q000209:etiology / Q000378:metabolism*; D007333:Insulin Resistance; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D019255:NADPH Oxidases / Q000378:metabolism; D009393:Nephritis / Q000209:etiology / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016207:Cytokines; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D043562:Receptors, G-Protein-Coupled; D016212:Transforming Growth Factor beta; D019255:NADPH Oxidases; D055372:AMP-Activated Protein Kinases