title: Contrast-induced nephropathy: pathogenesis and new therapeutic options for prevention.
abstract: Contrast-induced nephropathy is a common cause of inpatient and outpatient acute renal failure. The pathogenesis is complex adding difficulty to its management. Several preventive measures that involved the use of intravenous fluids and oral agents have been implemented in human studies with heterogeneous results because of the disparity in defining changes in glomerular filtration rate after renal injury. New preventive techniques based on the pathogenesis of contrast-induced nephropathy are being applied to human subjects with preliminary good outcomes. Future randomized trials will give us the opportunity to elucidate its benefits.
authors.affiliation: 1Division of Nephrology and Hypertension, Allegheny General Hospital, Temple University School of Medicine, Pittsburgh, PA; and 2Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ortega
authors.forename: Imad
authors.initials: I
authors.lastname: Harmouch
authors.forename: Ali
authors.initials: A
authors.lastname: Nayer
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control; D003287:Contrast Media / Q000009:adverse effects*; D005919:Glomerular Filtration Rate; D006801:Humans; D019194:Ischemic Preconditioning; D007668:Kidney / Q000098:blood supply; D009569:Nitric Oxide / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D017693:Sodium Bicarbonate / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D009569:Nitric Oxide; D017693:Sodium Bicarbonate; D010100:Oxygen