title: Sonochemical fabrication of dual-targeted redox-responsive smart microcarriers.
abstract: In the present study, the molecular and magnetic dual-targeted redox-responsive folic acid-cysteine-Fe3O4 microcapsules (FA-Cys-Fe3O4 MCs) have been synthesized via the sonochemical technique, and targeting molecule (folic acid) and Fe3O4 magnetic nanoparticles are introduced into the microcapsule shells successfully. The obtained FA-Cys-Fe3O4 MCs show excellent magnetic responsive ability by the oriented motion under an external magnetic field. The hydrophobic fluorescent dye (Coumarin 6) is successfully loaded into the FA-Cys-Fe3O4 MCs, demonstrating that it could be also easily realized to encapsulate hydrophobic drugs into the FA-Cys-Fe3O4 MCs when the drugs are dispersed into the oil phase before sonication. Cellular uptake demonstrates that FA-Cys-Fe3O4 MCs could target selectively the cells via folate-receptor-mediated endocytosis. Moreover, the FA-Cys-Fe3O4 MCs show their potential ability to be an attractive carrier for drug controlled release owing to the redox responsiveness of the disulfide in the microcapsule shells.
authors.affiliation: College of Chemistry, Jilin University , Changchun, 130012, P. R. China.
authors.forename: Zhanfeng
authors.initials: Z
authors.lastname: Li
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.forename: Bingnan
authors.initials: B
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Helmoth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Xuejun
authors.initials: X
authors.lastname: Cui
mesh_terms: D002214:Capsules / Q000138:chemical synthesis* / Q000528:radiation effects; D003545:Cysteine / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D005492:Folic Acid / Q000008:administration & dosage* / Q000737:chemistry; D006367:HeLa Cells; D019220:High-Energy Shock Waves; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D010084:Oxidation-Reduction / Q000528:radiation effects; D010316:Particle Size; D013010:Sonication / Q000379:methods*
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D005492:Folic Acid; D003545:Cysteine
keywords: dual-targeted; microcapsule; redox-responsive; sonochemical