title: Heteroatom-embedded medium-sized cycloalkynes: concise synthesis, structural analysis, and reactions.
abstract: A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.
authors.affiliation: Department of Molecular and Material Sciences, Kyushu University (Japan).
authors.forename: Runyan
authors.initials: R
authors.lastname: Ni
authors.forename: Naoto
authors.initials: N
authors.lastname: Mitsuda
authors.forename: Takeru
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Igawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tomooka
keywords: alkynes; cycloaddition; heterocycles; peptides; strained molecules