title: Risk assessment for preeclampsia in nulliparous women at 11-13 weeks gestational age: prospective evaluation of two algorithms.
abstract: OBJECTIVE
  To evaluate two algorithms for prediction of preeclampsia in a population of nulliparous women in Norway.
  
  
  METHODS
  Prospective screening study.
  
  
  METHODS
  National Centre for Fetal Medicine in Trondheim, Norway.
  
  
  METHODS
  Five hundred and forty-one nulliparous women.
  
  
  METHODS
  The women were examined between 11(+0) and 13(+6) weeks with interviews for maternal characteristics and measurements of mean arterial pressure, uterine artery pulsatility index, pregnancy-associated plasma protein A and placental growth factor. The First Trimester Screening Program version 2.8 by The Fetal Medicine Foundation (FMF) was compared with the Preeclampsia Predictor TM version 1 revision 2 by Perkin Elmer (PREDICTOR).
  
  
  METHODS
  Prediction of preeclampsia requiring delivery before 37 weeks, before 42 weeks and late preeclampsia (delivery after 34 weeks).
  
  
  RESULTS
  The performance of the two algorithms was similar, but quite poor, for prediction of preeclampsia requiring delivery before 42 weeks with an area under the curve of 0.77 (0.67-0.87) and sensitivity 40% (95% CI 19.1-63.9) at a fixed 10% false positive rate for FMF and 0.74 (0.63-0.84) and sensitivity 30% (95% CI 11.9-54.3) at a fixed 10% false positive rate for PREDICTOR. The FMF algorithm for preeclampsia requiring delivery <37 weeks had an area under the curve of 0.94 (0.86-1.0) and sensitivity of 80% (95% CI 28.4-99.5) at a 10% fixed false positive rate.
  
  
  CONCLUSIONS
  Fetal Medicine Foundation and PREDICTOR algorithms had similar and only modest performance in predicting preeclampsia. The results indicate that the FMF algorithm is suitable for prediction of preterm preeclampsia.
authors.affiliation: Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Obstetrics and Gynaecology, National Centre for Fetal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: R B
authors.initials: RB
authors.lastname: Skråstad
authors.affiliation: Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: G G
authors.initials: GG
authors.lastname: Hov
authors.affiliation: Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Obstetrics and Gynaecology, National Centre for Fetal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: H-G K
authors.initials: HG
authors.lastname: Blaas
authors.affiliation: Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: P R
authors.initials: PR
authors.lastname: Romundstad
authors.affiliation: Department of Obstetrics and Gynaecology, National Centre for Fetal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.|Department of Obstetrics and Gynaecology, Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: K Å
authors.initials: KÅ
authors.lastname: Salvesen
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D005865:Gestational Age; D006801:Humans; D009664:Norway; D010298:Parity; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D011446:Prospective Studies; D011673:Pulsatile Flow; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D011266:Pregnancy-Associated Plasma Protein-A
keywords: Biomarkers; Doppler; blood pressure; first trimester; preeclampsia; risk calculation; ultrasound; uterine artery