title: A genetic polymorphism in RBP4 is associated with coronary artery disease.
abstract: Insulin resistance and obesity is influenced by the retinol binding protein 4 (RBP4) adipokine. This study aims to determine if genetic polymorphisms in RBP4 are associated with the risk of coronary artery disease (CAD) in Chinese patients. RBP4 polymorphisms were analyzed by high resolution melting (HRM) analysis in a case-control study of 392 unrelated CAD patients and 368 controls from China. The Gensini score was used to determine the severity of CAD. The genotypic and allelic frequencies of RBP4 single-nucleotide polymorphisms were evaluated for associations with CAD and severity of disease. The A allele frequency was significantly higher in CAD case groups compared to control groups (16.7% vs. 8.8%) at the RBP4 rs7094671 locus. Compared to the G allele, this allele was associated with a higher risk of CAD (OR = 2.07 (1.50-2.84)). Polymorphisms at rs7094671 were found to associate with CAD using either a dominant or recessive model (OR, 95% CI: 1.97, 1.38-2.81; 3.81, 1.53-9.51, respectively). Adjusting for sex, history of smoking, serum TC, TG, LDL-c, and HDL-c, the risk of CAD for carriers remained signiﬁcantly higher in both dominant and recessive models (OR, 95% CI: 1.68, 1.12-2.51; 2.74, 1.00-7.52, respectively). However, this SNP was not significantly associated with severity of CAD using angiographic scores in multivariable linear regression models (p = 0.373). The RBP4 rs7094671 SNP is associated with CAD; however, our results do not indicate that this locus is associated with clinical severity of CAD or the extent of coronary lesions.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. wankeabm@sina.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Wan
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. zhaojianxun100@gmail.com.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu 610041, China. dengying03@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. cxweirdo@gmail.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. qzhang2000cn@yahoo.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. zengzhi@cd120.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. LiZhangdoc@yahoo.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China. chenyucheng2003@126.com.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
mesh_terms: D050197:Atherosclerosis / Q000235:genetics; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics*; D012307:Risk Factors
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma