title: Crystallographic study of PET radio-tracers in clinical evaluation for early diagnosis of Alzheimers.
abstract: The title compound, C24H25NO3·2CH3OH, which crystallized as a methanol disolvate, has applications as a PET radiotracer in the early diagnosis of Alzheimer's disease. The dihedral angle between the biphenyl rings is 8.2 (2)° and the heterocyclic ring adopts a half-chair conformation with the N atom adopting a pyramidal geometry (bond-angle sum = 327.6°). The C atoms of both meth-oxy groups lie close to the plane of their attached ring [deviations = 0.107 (6) and 0.031 (6) Å]. In the crystal, the components are linked by O-H⋯O and O-H⋯N hydrogen bonds, generating [010] chains. C-H⋯O inter-actions are also observed.
authors.affiliation: Istituto di Cristallografia, Via G. Amendola, 122/o, 7016, Bari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Altomare
authors.affiliation: Dip. di Farmacia-Scienze del Farmaco, Universita' degli studi di Bari, Via Orabona, 4, 70125, Bari, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Capparelli
authors.affiliation: Dip. di Farmacia-Scienze del Farmaco, Universita' degli studi di Bari, Via Orabona, 4, 70125, Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrieri
authors.affiliation: Dip. di Farmacia-Scienze del Farmaco, Biofordrug, srl, Universita' degli studi di Bari, Via Orabona, 4, 70125, Bari, Italy.
authors.forename: Nicola A
authors.initials: NA
authors.lastname: Colabufo
authors.affiliation: Istituto di Cristallografia, Via G. Amendola, 122/o, 7016, Bari, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Moliterni
authors.affiliation: Istituto di Cristallografia, Via G. Amendola, 122/o, 7016, Bari, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Rizzi
authors.affiliation: Istituto di Cristallografia, Via G. Amendola, 122/o, 7016, Bari, Italy.
authors.forename: Dritan
authors.initials: D
authors.lastname: Siliqi
keywords: P-glycoprotein inhibitor; PET radiotracer; crystal structure; hydrogen bonds; ligands