title: Tablets compressed with gastric floating pellets coated with acrylic resin for gastro retention and sustained release of famotidine: in-vitro and in-vivo study.
abstract: OBJECTIVE
  The aim of this study was to prepare a disintegrating gastric floating tablet composed of floating pellets coated with acrylic resin to prolong the gastric residence time and increase the oral bioavailability of famotidine.
  
  
  METHODS
  The gastric floating pellets containing famotidine, stearyl alcohol and microcrystalline cellulose (1 : 10 : 1) were prepared by extrusion-spheronization process and coated with acrylic resin, then compressed into tablets with Avicel PH 301 pellets and cross-linked polyvinylpyrrolidone. The coating weight, volume ratio of Eudragit RL30 D and RS30 D and solid content of coating fluid were optimized by Box-Behnken design.
  
  
  RESULTS
  In 0.1 M HCl, tablets can immediately disintegrate into pellets which can remain floating and sustained drug releasing over 12 h. The AUC0-∞ of famotidine gastric floating pellets (7776.52 ± 1065.93 h ng/ml) administered into rats was significantly higher than that of marketed rapid release tablets Xingfading® (Xingyi, Shanghai, China) (4166.23 ± 312.43 h ng/ml), while the relative bioavailability was 187.01 ± 22.81%.
  
  
  CONCLUSIONS
  The experimental results indicated that the optimized formulation did offer a new gastro retention and sustained release approach to enhance the oral absorption of famotidine.
authors.affiliation: Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, China.
authors.forename: Xiaole
authors.initials: X
authors.lastname: Qi
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Huiting
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002482:Cellulose / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D015738:Famotidine / Q000008:administration & dosage*; D006851:Hydrochloric Acid / Q000737:chemistry; D007408:Intestinal Absorption; D011109:Polymethacrylic Acids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D011312:Pressure; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000737:chemistry*; D013607:Tablets
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D015738:Famotidine; D002482:Cellulose; D011205:Povidone; C109691:microcrystalline cellulose; D006851:Hydrochloric Acid
keywords: bioavailability; famotidine; floating drug delivery system; pellets; tablets