title: Validation of magnetocardiography versus fractional flow reserve for detection of coronary artery disease.
abstract: BACKGROUND
  Although magnetocardiography (MCG) has been proposed as a non-invasive technique with high accuracy for functional diagnosis of myocardial injury, the validation of MCG against fractional flow reserve FFR in diagnosing coronary artery disease (CAD) has not yet been established. The goal of the study was to determine the diagnostic accuracy of MCG versus invasively determined FFR in patients with suspected or known CAD.
  
  
  METHODS
  Forty seven patients with suspected CAD (35 men; mean age 69 years) who underwent coronary angiography and FFR measurement were enrolled. FFR ≤ 0.8 was considered to indicate significant myocardial ischemia. The change of ST-segment fluctuation score from rest to stress was calculated from the MCG. In addition, two blinded cardiologists assessed MCG images that were visualized by post-processing method, bull's-eye mapping.
  
  
  RESULTS
  The best cut-off value of the percent change of ST-segment fluctuation score was -39.0% with sensitivity of 86.7% and specificity of 73.9%. Sensitivity, specificity, diagnostic accuracy, and the area under the receiver-operator characteristics curve of bull's-eye mapping for the detection of significant CAD were 90.5%, 92.3%, 91.5%, and 0.914 on a patient basis and 90.0%, 93.8%, 92.3%, and 0.919 by coronary territory, respectively.
  
  
  CONCLUSIONS
  MCG accurately detects functionally significant CAD as defined by using FFR, provides an assessment of ischemic status in agreement with the change of ST-segment fluctuation score, and accurately localizes the ischemic territory in bull's eye mapping. Therefore, MCG may provide an incremental value for prediction of myocardial ischemia non-invasively and safely in clinical practice with fast examination time.
authors.affiliation: Coburg Hospital, 2nd Medical Department, Coburg, Germany Asklepios Hospital Harburg, 1st Medical Department, Hamburg, Germany.
authors.forename: Jai-Wun
authors.initials: JW
authors.lastname: Park
authors.affiliation: Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea.
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Shin
authors.affiliation: Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea.
authors.forename: Soe Hee
authors.initials: SH
authors.lastname: Ann
authors.affiliation: Coburg Hospital, 2nd Medical Department, Coburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Gödde
authors.affiliation: Coburg Hospital, 2nd Medical Department, Coburg, Germany.
authors.forename: Lea Song-I
authors.initials: LS
authors.lastname: Park
authors.affiliation: Coburg Hospital, 2nd Medical Department, Coburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Brachmann
authors.affiliation: Asklepios Hospital Harburg, 1st Medical Department, Hamburg, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Vidal-Lopez
authors.affiliation: Asklepios Hospital Harburg, 1st Medical Department, Hamburg, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Wierzbinski
authors.affiliation: Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.
authors.forename: Yat-Yin
authors.initials: YY
authors.lastname: Lam
authors.affiliation: Institute for Clinical Hemostasiology and Transfusion Medicine, University of Saarland, Homburg/Saar, Germany.
authors.forename: Friedrich
authors.initials: F
authors.lastname: Jung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000503:physiopathology*; D023921:Coronary Stenosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D053798:Magnetocardiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011446:Prospective Studies
keywords: Magnetocardiography; coronary artery disease; fractional flow reserve; ischemia