title: Adopting the principles of collagen biomineralization for intrafibrillar infiltration of yttria-stabilized zirconia into three-dimensional collagen scaffolds.
abstract: In this paper, we report a process for generating collagen-yttria-stabilized amorphous zirconia hybrid scaffolds by introducing acetylacetone-inhibited zirconia precursor nanodroplets into a poly(allylamine)-coated collagen matrix. This polyelectrolyte coating triggers intrafibrillar condensation of the precursors into amorphous zirconia, which is subsequently transformed into tetragonal yttria-stabilized zirconia after calcination. Our findings represent a new paradigm in the synthesis of non-naturally occurring collagen-based hybrid scaffolds under alcoholic mineralizing conditions.
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan (PR China).
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: School of Stomatology, Fourth Military Medical University, Xi'an (PR China).
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Niu
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan (PR China).
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan (PR China).
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, Maryland (USA).
authors.forename: Dwayne D
authors.initials: DD
authors.lastname: Arola
authors.affiliation: University of Trieste, Trieste and IGM-CNR, Bologna (Italy).
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Breschi
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan (PR China).
authors.forename: Jing
authors.initials: J
authors.lastname: Mao
authors.affiliation: School of Stomatology, Fourth Military Medical University, Xi'an (PR China).
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Georgia Health Sciences University, Augusta, Georgia, 30912-1129 (USA) Tel: (706) 7212031.
authors.forename: David H
authors.initials: DH
authors.lastname: Pashley
authors.affiliation: Georgia Health Sciences University, Augusta, Georgia, 30912-1129 (USA) Tel: (706) 7212031.
authors.forename: Franklin R
authors.initials: FR
authors.lastname: Tay
keywords: Biomimetic synthesis; Collagen; Intrafibrillar; Zirconia