title: Giant left ventricular thrombus formation associated with heparin-induced thrombocytopenia.
abstract: A 33-year-old man underwent urgent coronary artery de-obstruction for acute thrombotic occlusion of the left descending coronary artery. After 10 days of antiplatelet and heparin therapy, ventriculographic and echocardiographic control revealed a giant thrombus in the left ventricle, an ejection fraction of 40%, and severe mitral regurgitation. Heparin-induced thrombocytopenia was diagnosed. After urgent mitral valve annuloplasty and left ventricular thrombectomy, the patient was discharged. In the literature, several cases of right atrial and ventricular thrombi have been described; however, to the best of our knowledge, this is the first report of giant left ventricular thrombus during heparin-induced thrombocytopenia.
authors.affiliation: Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: campisis@hotmail.com.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Campisi
authors.affiliation: Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Fuzellier
authors.affiliation: Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Marco
authors.initials: M
authors.lastname: Vola
authors.affiliation: Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Favre
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects; D004452:Echocardiography; D005500:Follow-Up Studies; D015637:Gated Blood-Pool Imaging; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006352:Heart Ventricles; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017131:Thrombectomy / Q000379:methods*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
chemical_list: D000925:Anticoagulants; D006493:Heparin