title: Tumour necrosis factor-α/interleukin-10 ratio in patients with obstructive sleep apnoea hypopnoea syndrome.
abstract: OBJECTIVE
  To explore the significance of the tumour necrosis factor-α/interleukin-10 ratio and the effect of continuous positive airway pressure in patients with different degrees of obstructive sleep apnoea hypopnoea syndrome severity.
  
  
  METHODS
  This study comprised 135 patients with obstructive sleep apnoea hypopnoea syndrome and 94 control subjects.
  
  
  RESULTS
  Tumour necrosis factor-α and tumour necrosis factor-α/interleukin-10 ratio values were significantly higher in the obstructive sleep apnoea hypopnoea syndrome group than in the control group, but interleukin-10 was significantly lower. Tumour necrosis factor-α/interleukin-10 ratio values increased in line with the severity of obstructive sleep apnoea hypopnoea syndrome. In multivariate analysis, the tumour necrosis factor-α/interleukin-10 ratio correlated positively with the apnoea-hypopnoea index and all indices of obstructive sleep apnoea hypopnoea syndrome, except for age, body mass index and neck circumference. After one month of continuous positive airway pressure therapy, levels of tumour necrosis factor-α decreased; interleukin-10 showed no change.
  
  
  CONCLUSIONS
  The results suggest that inflammation is activated and anti-inflammatory cytokines are decreased in obstructive sleep apnoea hypopnoea syndrome patients. Tumour necrosis factor-α/interleukin-10 ratio may prove useful for severity monitoring and management of obstructive sleep apnoea hypopnoea syndrome patients, and may reduce the need for polysomnography.
authors.affiliation: Clinical Laboratory,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Clinical Laboratory,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: H
authors.initials: H
authors.lastname: Cao
authors.affiliation: Department of Otolaryngology,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Cardiology,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: F
authors.initials: F
authors.lastname: Cao
authors.affiliation: Department of Otolaryngology,Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science,Xiangyang,PR China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D017677:Age Distribution; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009333:Neck / Q000033:anatomy & histology; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: Interleukin-10