title: Preliminary investigation of a novel technique for the quantification of the ex vivo biomechanical properties of the vocal folds.
abstract: The human vocal fold is a complex structure made up of distinct layers that vary in cellular and extracellular matrix composition. Elucidating the mechanical properties of vocal fold tissues is critical for the study of both acoustics and biomechanics of voice production, and essential in the context of vocal fold injury and repair. Both quasistatic and dynamic behavior in the 10-300 Hz range was explored in this preliminary investigation. The resultant properties of the lamina propria were compared to that of the nearby thyroarytenoid muscle. Er, quantified via quasistatic testing of the lamina propria, was 609±138 MPa and 758±142 MPa in the muscle (p=0.001). E' of the lamina propria as determined by dynamic testing was 790±526 MPa compared to 1061±928 MPa in the muscle. Differences in E' did not achieve statistical significance via linear mixed effect modeling between the tissue types (p=0.95). In addition, frequency dependence was not significant (p=0.18).
authors.affiliation: Biomaterials and Biomimetics, College of Dentistry, New York University, New York, NY, USA. Electronic address: pc92@nyu.edu.
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
authors.affiliation: Orthopedic Surgery, Hospital for Joint Diseases, New York University, New York, NY, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Sobieraj
authors.affiliation: Biomaterials and Biomimetics, College of Dentistry, New York University, New York, NY, USA.
authors.forename: Nick
authors.initials: N
authors.lastname: Tovar
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Andrews
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Paul
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Nandini
authors.initials: N
authors.lastname: Govil
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Seema
authors.initials: S
authors.lastname: Jeswani
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Milan R
authors.initials: MR
authors.lastname: Amin
authors.affiliation: Departments of Public Health and Epidemiology, New York University, New York, NY, USA.
authors.forename: Malvin N
authors.initials: MN
authors.lastname: Janal
authors.affiliation: NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Branski
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D009092:Mucous Membrane / Q000502:physiology; D009132:Muscles / Q000502:physiology; D011817:Rabbits; D014827:Vocal Cords / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
keywords: Dynamic; Mechanical testing; Quasi-static; Rabbit; Vocal fold