title: For Stage II Node-Positive Breast Cancer, is it Worthwhile to Consider Adjuvant Radiotherapy Following Mastectomy?
abstract: OBJECTIVE
  To evaluate overall survival (OS), progression-free survival (PFS), loco-regional recurrence (LRR), and toxicities for early breast-cancer patients with one to three positive axillary lymph nodes, by the addition of radiotherapy to adjuvant chemotherapy.
  
  
  METHODS
  Patients were eligible for enrollment into the study if they had pathologically proven stages II breast cancer, with one to three positive axillary lymph nodes. Patients were assigned to one of the two groups; Group 1; adjuvant chemotherapy then radiotherapy, and group 2; adjuvant chemotherapy only.
  
  
  RESULTS
  Between September 2008 and August 2014, 75 patients were enrolled. Forty patients group 1, and 35 group 2. The 4-year OS for group 1, and two were 77.5 and 71.4%, respectively. The 4-year PFS for group 1 and 2 were 72.5 and 60%, respectively. During the 54 months follow-up period, 11 patients from group 1 had recurrence (three locoregional, seven metastatic, and one both), and 14 patients from group 2 had recurrence (seven locoregional, three metastatic, and four both). The distant metastasis rate was the same in the two groups. However, the metastasis sites were different in the two groups.
  
  
  CONCLUSIONS
  The addition of radiotherapy in stage II breast cancer with one to three positive lymph nodes improved the PFS, and LRR. Radiotherapy improved OS in patients with high-risk features.
authors.affiliation: General Organization For Teaching Hospitals and Institutes , Cairo , Egypt.
authors.forename: Mohammed A M
authors.initials: MA
authors.lastname: Osman
authors.affiliation: Department of Oncology, Ain Shams University , Cairo , Egypt.
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Elkady
authors.affiliation: Department of Oncology, Ain Shams University , Cairo , Egypt.
authors.forename: Khalid E
authors.initials: KE
authors.lastname: Nasr
keywords: breast; group; radiotherapy; survival; toxicity