title: A critical look at local-regional management of peritoneal metastasis.
abstract: For patients with stage IV colorectal cancer, the presence of peritoneal metastases is a poor prognostic feature. Despite the improvement in systemic therapy, long-term survival remains poor for patients with peritoneal carcinomatosis. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can be associated with long-term survival in patients who have limited peritoneal disease, particularly those who can have complete cytoreduction. Whether the possible benefit of CRS and HIPEC is from the surgical resection of all disease or the combination of CRS and HIPEC remains unclear.
authors.affiliation: Division of Surgical Oncology, Massachusetts General Hospital Cancer Center, Yawkey 7B, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Carlos H F
authors.initials: CH
authors.lastname: Chan
authors.affiliation: Division of Surgical Oncology, Massachusetts General Hospital Cancer Center, Yawkey 7B, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Cusack
authors.affiliation: Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Yawkey 7B, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: DPRYAN@mgh.harvard.edu.
authors.forename: David P
authors.initials: DP
authors.lastname: Ryan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures; D019468:Disease Management; D006801:Humans; D006979:Hyperthermia, Induced; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Carcinomatosis; Colorectal cancer; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; Systemic chemotherapy