title: Tissue engineered scaffolds in regenerative medicine.
abstract: Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications.
authors.affiliation: Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran;
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hosseinkhani
authors.affiliation: Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
authors.affiliation: Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran;
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Karimfar
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical sciences, Ilam, Iran;
authors.forename: Salar
authors.initials: S
authors.lastname: Bakhtiyari
authors.affiliation: Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Amir
authors.initials: A
authors.lastname: Manafi
authors.affiliation: Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; ; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Shirazi
keywords: Regenerative medicine; Scaffold; Stem cells; Tissue engineering