title: Evaluation of prenatal and postnatal diagnostic criteria for twin anemia-polycythemia sequence.
abstract: OBJECTIVE
  The aim of this study is to analyze the relevance of the prenatal and postnatal diagnostic parameters of twin anemia-polycythemia sequence (TAPS).
  
  
  METHODS
  Diagnostic data of all cases of TAPS followed in our institution between 2006 and 2013 were reviewed. Statistical analyses were conducted using Bayesian methods.
  
  
  RESULTS
  Twenty cases of TAPS were included. We found a relationship between the hemoglobin level and the middle cerebral artery peak systolic velocity (coefficient -0.25 [-0.34, -0.15], Pr(coef < 0) = 99.99%). Sensitivity and specificity of the prenatal diagnosis were 71% and 50%, respectively, regarding the correspondence with postnatal diagnosis. There was no correlation between the number [odds ratio (OR) = 0.89 [0.72, 1.10], Pr(OR > 1) = 14.8%)], the mean diameter (OR = 0.98 [0.32, 3.06], Pr(OR > 1) = 48.9%), or the total diameter (OR = 0.79 [0.36, 1.53], Pr(OR > 1) = 26.3%) of arteriovenous anastomoses and the severity of TAPS.
  
  
  CONCLUSIONS
  Middle cerebral artery peak systolic velocity is a reliable tool for estimating the hemoglobin level in cases of TAPS. The correspondence between prenatal and postnatal diagnosis is imperfect. Further studies are required to evaluate opportunity of widening postnatal diagnostic criteria. © 2014 John Wiley & Sons, Ltd.
authors.affiliation: Department of Obstetrics and Gynecology, Strasbourg University Teaching Hospital, Strasbourg, France; Federation of Translational Medicine, Strasbourg University Teaching Hospital, Strasbourg, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Veujoz
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sananès
authors.forename: François
authors.initials: F
authors.lastname: Severac
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Weingertner
authors.forename: Monique
authors.initials: M
authors.lastname: Kohler
authors.forename: Fernando
authors.initials: F
authors.lastname: Guerra
authors.forename: Adrien
authors.initials: A
authors.lastname: Gaudineau
authors.forename: Israël
authors.initials: I
authors.lastname: Nisand
authors.forename: Romain
authors.initials: R
authors.lastname: Favre
mesh_terms: D000328:Adult; D000751:Anemia, Neonatal / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D001499:Bayes Theorem; D001783:Blood Flow Velocity; D015331:Cohort Studies; D005260:Female; D005330:Fetofetal Transfusion / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D005865:Gestational Age; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D011086:Polycythemia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D011247:Pregnancy; D059285:Pregnancy, Twin; D011446:Prospective Studies; D014430:Twins, Monozygotic; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D006454:Hemoglobins