title: Rho GTPases in embryonic development.
abstract: In the last decade, several mouse models for RhoA, Rac1, and Cdc42 have emerged and have contributed a great deal to understanding the precise functions of Rho GTPases at early stages of development. This review summarizes our current knowledge of various mouse models of tissue-specific ablation of Cdc42, Rac1, and RhoA with emphasis on early embryogenesis, epithelial and skin morphogenesis, tubulogenesis, development of the central nervous system, and limb development.
authors.affiliation: a McGill University ; Department of Anatomy and Cell Biology ; Montreal , QC Canada.
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Duquette
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lamarche-Vane
mesh_terms: D000818:Animals; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D020764:cdc42 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein
chemical_list: C581598:Cdc42 protein, mouse; D009479:Neuropeptides; C484602:Rac1 protein, mouse; C526380:RhoA protein, mouse; D020764:cdc42 GTP-Binding Protein; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein
keywords: Cdc42; Rac1; RhoA; cell fate; cell migration; cell polarity; cytoskeleton; embryonic development; mouse models; tubulogenesis