title: Synergetic signal amplification based on electrochemical reduced graphene oxide-ferrocene derivative hybrid and gold nanoparticles as an ultra-sensitive detection platform for bisphenol A.
abstract: In this paper, a novel electro-active graphene oxide (GO) nanocomposite was firstly prepared by covalently grafted (4-ferrocenylethyne) phenylamine (Fc-NH2) onto the surface of GO. The synthesized hybridized nanocomposite of GO-Fc-NH2 coupled with HAuCl4 simultaneously electrodeposited on the glassy carbon electrodes (GCE) to obtain rGO-Fc-NH2/AuNPs/GCE. The covalently grafted material of the rGO-Fc-NH2/AuNPs film can effectively prevent the electron mediator leaking from the electrode surface, which can hold the advantage of both the nanomaterials and electron mediator. By employing the catalysis effect of the nanomaterial and electron mediator coupling with large active surface area and high accumulation capacity of rGO-Fc-NH2/AuNPs, a synergetic signal amplification platform for ultra-sensitive detection of bisphenol A (BPA) was successfully established. With this novel sensor, the oxidation peak currents of BPA were linearly dependent on the BPA concentrations in the range of 0.005-10 μM with the detection limit of 2 nM. Modification of electron mediators on nanomaterials can greatly enhance the electrochemical performance of the sensors and will provide a new concept for fabricating newly electro-active nanomaterials-based electrochemical biosensors.
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Huang
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China. Electronic address: liumeilingww@126.com.
authors.forename: Meiling
authors.initials: M
authors.lastname: Liu
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Youyu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000032:analysis*; D055664:Electrochemical Techniques; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D000075163:Metallocenes; D008892:Milk / Q000737:chemistry; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D010636:Phenols / Q000032:analysis*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D005296:Ferrous Compounds; D006046:Gold; D006108:Graphite; D000075163:Metallocenes; D010087:Oxides; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C004998:ferrocene
keywords: (4-Ferrocenylethyne) phenylamine; BPA detection; Functional graphene oxide; Synergetic signal amplification