title: Prognostic value and clinical implication of serum ferritin levels following allogeneic hematopoietic cell transplantation.
abstract: Little research has been done on changes in serum ferritin (s-ferritin) levels and clinical implications following allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluated the correlation of s-ferritin levels after HCT with survival in 203 patients. The s-ferritin level was significantly elevated, with 75% of the patients showing peak levels 90 days after HCT. The level was >10,000 ng/ml in a total of 43% of the patients, a finding that was associated with febrile neutropenia or infection. The s-ferritin level at day 30 and at 1 year after HCT was significantly associated with prognosis. However, this statistically significant relationship was lost after adjusting for acute-phase reactants. We conclude that hyperferritinemia is very common and the degree of influence of a red blood cell transfusion will vary depending on the phase after HCT. A prospective study is needed to determine if iron load in and of itself contributes to a worse prognosis after HCT.
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Nakamae
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Shiro
authors.initials: S
authors.lastname: Koh
authors.forename: Hideo
authors.initials: H
authors.lastname: Koh
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Nishimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Asao
authors.initials: A
authors.lastname: Hirose
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D002908:Chronic Disease; D018572:Disease-Free Survival; D020031:Epstein-Barr Virus Infections / Q000401:mortality* / Q000628:therapy*; D017707:Erythrocyte Transfusion; D005260:Female; D005293:Ferritins; D006402:Hematologic Diseases / Q000401:mortality* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007239:Infections / Q000209:etiology / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology / Q000401:mortality / Q000628:therapy; D015996:Survival Rate
chemical_list: D005293:Ferritins