title: Transition metal free intramolecular selective oxidative C(sp3)-N coupling: synthesis of N-aryl-isoindolinones from 2-alkylbenzamides.
abstract: A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp(3))-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 °C.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-pass Road, Bhauri, Bhopal, Madhya Pradesh, India-462 066. sangitkumar@iiserb.ac.in.
authors.forename: Ajay
authors.initials: A
authors.lastname: Verma
authors.forename: Saket
authors.initials: S
authors.lastname: Patel
authors.lastname: Meenakshi
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Yadav
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Sadhan
authors.initials: S
authors.lastname: Jana
authors.forename: Shubham
authors.initials: S
authors.lastname: Sharma
authors.forename: Ch Durga
authors.initials: ChD
authors.lastname: Prasad
authors.forename: Sangit
authors.initials: S
authors.lastname: Kumar