title: Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy.
abstract: The fully automated solid-phase synthetic strategy of hairpin pyrrole-imidazole polyamides is described. A key advance is the development of methodology for the application of triphosgene as a coupling agent in the automated synthesis of hairpin polyamides without racemization. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in good yield (9-15%) and crude purity.
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055, P. R. China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Fang
authors.forename: Guiyang
authors.initials: G
authors.lastname: Yao
authors.forename: Zhengyin
authors.initials: Z
authors.lastname: Pan
authors.forename: Chunlei
authors.initials: C
authors.lastname: Wu
authors.forename: Heng-Shan
authors.initials: HS
authors.lastname: Wang
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Burley
authors.forename: Wu
authors.initials: W
authors.lastname: Su
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; D004247:DNA