title: Nardosinane-type sesquiterpenoids of Nardostachys chinensis Batal.
abstract: Four new nardosinane-type sesquiterpenoids nardosinanones F-I (1-2, 4-5), along with eight known sesquiterpenoids (3, 6-12) were isolated from the underground parts of Nardostachys chinensis Batal. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 were new nardosinane sesquiterpenoids processing a rare 4,11-epoxy group in nature. In addition, compounds 1, 5-7, 11 and 12 showed protective effects on neonatal rat cardiomyocyte injury induced by hydrogen peroxide.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Liu
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Li
authors.affiliation: State-Province Key Laboratory of Biomedicine-Pharmaceutics of China, Department of Pharmacology, Harbin Medical University, Harbin 150086, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: daiyi1004@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006861:Hydrogen Peroxide / Q000009:adverse effects; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects*; D032404:Nardostachys / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D012717:Sesquiterpenes; D006861:Hydrogen Peroxide
keywords: Myocardial injury; Nardosinane-type sesquiterpenoids; Nardostachys chinensis Batal