title: Reshuffling transcriptional circuits: how microorganisms adapt to colonize the human body.
abstract: Several hundred taxa of microorganisms-including bacteria, archaea and eukaryotes-inhabit the human body. What did it take for these species to become stable residents of humans? Recent reports illustrate how evolutionary changes in transcriptional circuits played a pivotal role in the adaptation of single-celled eukaryotes to colonize mammals.
authors.affiliation: a Institut für Molekulare Infektionsbiologie ; Universität Würzburg ; Würzburg , Germany.
authors.forename: Sonakshi
authors.initials: S
authors.lastname: De
authors.forename: J Christian
authors.initials: JC
authors.lastname: Pérez
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D001105:Archaea / Q000378:metabolism* / Q000472:pathogenicity; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D056890:Eukaryota / Q000378:metabolism* / Q000472:pathogenicity; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals / Q000382:microbiology*; D014158:Transcription, Genetic; D014774:Virulence
keywords: evolution; microbiota; regulator; transcriptional circuits; yeast