title: Dual-cargo selectively controlled release based on a pH-responsive mesoporous silica system.
abstract: A pH-controlled delivery system based on mesoporous silica nanoparticles (MSNs) was constructed for dual-cargo selective release. To achieve a better controlled-release effect, a modified sol-gel method was employed to obtain MSNs with tunable particle and pore sizes. The systems selectively released different kinds of cargo when stimulated by different pH values. At the lower pH value (pH 2.0) only one kind of cargo was released from the MSNs, whereas at a higher pH value (pH 7.0) only the other kind of cargo was released from the MSNs. The multi-cargo delivery system has brought the concept of selective release to new advances in the field of functional nanodevices and allows more accurate and controllable delivery of specific cargoes, which is expected to have promising applications in nanomedicine.
authors.affiliation: Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, 100083 Beijing, (China).
authors.forename: Wanyuan
authors.initials: W
authors.lastname: Gui
authors.forename: Wenqian
authors.initials: W
authors.lastname: Wang
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Jiao
authors.forename: Lifeng
authors.initials: L
authors.lastname: Chen
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; C509968:MCM-41; D012235:Rhodamines; D012822:Silicon Dioxide; D009113:Muramidase
keywords: drug delivery; mesoporous materials; nanostructures; sensors; sol-gel processes