title: Potential role of High mobility group box 1 in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is characterized as a typical inflammation-related carcinoma. High mobility group box protein 1 (HMGB1), a non-histone DNA-binding protein, is identified as a potent proinflammatory mediator when presents extracellularly. Recently, a growing body of evidence indicates that HMGB1 plays a potential role in HCC, but many questions remain unanswered about the relationship between HMGB1 and HCC formation and development. This review focuses on the biological effect of HMGB1, and discusses the association of HMGB1 with HCC and potential use of strategies targeting HMGB1 in HCC treatment.
authors.affiliation: a Department of infectious diseases and Key laboratory of liver hepatitis in Hunan ; Xiangya Hospital ; Central South University ; Changsha , PR China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Zhou
authors.forename: Xu-Yuan
authors.initials: XY
authors.lastname: Kuang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Ming-Xiang
authors.initials: MX
authors.lastname: Zou
authors.forename: Dao-Lin
authors.initials: DL
authors.lastname: Tang
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Fan
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D024243:HMGB1 Protein
keywords: biological effect; chronic hepatitis; hepatocellular carcinoma; high mobility group box protein 1; tumor microenvironment