title: Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy.
abstract: Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma. First-line treatment is surgical excision, though nonsurgical treatment modalities such as 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and imiquimod also have been investigated for this neoplasm. Unfortunately, recurrences are known to occur after both surgical and nonsurgical monotherapies. We report a case of perianal SCCIS that was successfully treated with a novel combination of ALA-PDT and imiquimod.
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Bontumasi
authors.forename: David
authors.initials: D
authors.lastname: Sheinbein
authors.affiliation: Center for Dermatologic and Cosmetic Surgery, Washington University School of Medicine, 969 Mason Rd, Ste 200, St Louis, MO 63141, USA. ehurst@dom.wustl.edu.
authors.forename: Eva A
authors.initials: EA
authors.lastname: Hurst
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D000634:Aminoquinolines / Q000008:administration & dosage*; D001003:Anal Canal / Q000473:pathology / Q000601:surgery; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D004210:Dissection / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; D000077271:Imiquimod