title: Efficient prediction of human protein-protein interactions at a global scale.
abstract: BACKGROUND
  Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods.
  
  
  RESULTS
  On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments.
  
  
  CONCLUSIONS
  The speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.
authors.affiliation: School of Computer Science, Carleton University, Ottawa, Canada. aschoenr@scs.carleton.ca.
authors.forename: Andrew
authors.initials: A
authors.lastname: Schoenrock
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. bahramsamanfar@gmail.com.
authors.forename: Bahram
authors.initials: B
authors.lastname: Samanfar
authors.affiliation: School of Computer Science, Carleton University, Ottawa, Canada. sylverbullit@hotmail.com.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Pitre
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. mohsen.hooshyar@gmail.com.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hooshyar
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada. jin@utoronto.ca.
authors.forename: Ke
authors.initials: K
authors.lastname: Jin
authors.affiliation: Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, Tennessee, USA. cphillip@eecs.utk.edu.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Phillips
authors.affiliation: Department of Pediatrics, Gothenburg University, Gothenburg, Sweden. hui.wang@gu.se.|The Centre for Individualized Medication, Linköping University, Linköping, Sweden. hui.wang@gu.se.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada. srphanse@gmail.com.
authors.forename: Sadhna
authors.initials: S
authors.lastname: Phanse
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. katayoun10@yahoo.com.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Omidi
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. yuangui2@hotmail.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gui
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. md_alamgir@yahoo.com.
authors.forename: Md
authors.initials: M
authors.lastname: Alamgir
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. alex_wong@carleton.ca.
authors.forename: Alex
authors.initials: A
authors.lastname: Wong
authors.affiliation: Department of Pediatrics, Gothenburg University, Gothenburg, Sweden. fredrik.barrenas@pediat.gu.se.|The Centre for Individualized Medication, Linköping University, Linköping, Sweden. fredrik.barrenas@pediat.gu.se.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Barrenäs
authors.affiliation: Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, Saskatchewan, Canada. mohanbabu_r@yahoo.com.
authors.forename: Mohan
authors.initials: M
authors.lastname: Babu
authors.affiliation: Department of Pediatrics, Gothenburg University, Gothenburg, Sweden. mikael.benson@liu.se.|The Centre for Individualized Medication, Linköping University, Linköping, Sweden. mikael.benson@liu.se.
authors.forename: Mikael
authors.initials: M
authors.lastname: Benson
authors.affiliation: Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, Tennessee, USA. langston@eecs.utk.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Langston
authors.affiliation: Department of Systems and Computer Engineering, Carleton University, Ottawa, Canada. jrgreen@sce.carleton.ca.
authors.forename: James R
authors.initials: JR
authors.lastname: Green
authors.affiliation: School of Computer Science, Carleton University, Ottawa, Canada. frank@dehne.net.
authors.forename: Frank
authors.initials: F
authors.lastname: Dehne
authors.affiliation: Department of Biology, Carleton University, Ottawa, Canada. ashkan_golshani@carleton.ca.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Golshani
mesh_terms: D019295:Computational Biology / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000378:metabolism*; D020543:Proteome / Q000032:analysis*; D012984:Software
chemical_list: D011506:Proteins; D020543:Proteome