title: Application of Proteomic Tools in Modern Nanotechnological Approaches Towards Effective Management of Neurodegenerative Disorders.
abstract: Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease, and Huntington's disease. Due to recent advancements in highthroughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of agerelated neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Ali
authors.forename: Ishfaq Ahmed
authors.initials: IA
authors.lastname: Sheikh
authors.forename: Zeenat
authors.initials: Z
authors.lastname: Mirza
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
authors.forename: Adel M
authors.initials: AM
authors.lastname: Abuzenadah
authors.forename: Ghazi A
authors.initials: GA
authors.lastname: Damanhouri
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia. gashraf@kau.edu.sa.
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
mesh_terms: D000367:Age Factors; D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000503:physiopathology; D040901:Proteomics / Q000379:methods*