title: An autopsy case of unicentric Castleman's disease associated with bronchiolitis obliterans.
abstract: A 34-year-old woman visited the hospital suffering from enanthema of the tongue, hair loss, and nonproductive cough. Corticosteroid administration slightly resolved the enanthema and hair loss, but not the nonproductive cough. She was transferred to another hospital for the resection of a retroperitoneal mass, which was histopathologically diagnosed as unicentric, hyaline vascular type Castleman's disease. She was then referred to our hospital due to progressive dyspnea and was diagnosed as having bronchiolitis obliterans based on computed tomography scan findings and a lung function test, while paraneoplastic pemphigus was clinically considered for her enanthema. After her death from respiratory failure in spite of corticosteroid administration, autopsy confirmed constrictive bronchiolitis in the lung. Mucocutaneous lesions, clinically considered as paraneoplastic pemphigus, were histologically different from pemphigus. The constrictive bronchiolitis and other pathological findings, including nonviral chronic hepatitis and interstitial nephritis, confirmed the diagnosis of paraneoplastic autoimmune multiorgan syndrome associated with the Castleman's disease.
authors.affiliation: Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Asthma and Allergy Center, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Ohshima
authors.affiliation: Department of Clinical Research, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shimada
authors.affiliation: Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawashima
authors.affiliation: Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Department of Clinical Research, National Hospital Organization Tokyo National Hospital Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hebisawa
keywords: Bronchiolitis obliterans; paraneoplastic autoimmune multiorgan syndrome; paraneoplastic pemphigus; unicentric Castleman’s disease