title: Safety and efficacy of a novel plastic stent coated with stone-dissolving agents for the treatment of biliary stones in a porcine model.
abstract: OBJECTIVE
  We previously reported on a plastic stent that was coated with ethylenediaminetetraacetic acid (EDTA) and sodium cholate, which dissolved common bile duct (CBD) stones ex vivo. The aim of this study was to investigate the safety and efficacy of such stents on biliary stones in a live porcine model.
  
  
  METHODS
  Stents without coating or with degradable membranes containing 0 % or 50 % EDTA and sodium cholate were inserted together with human CBD stones into the porcine CBD. Serum laboratory variables, histological examinations of the bile duct, and the weight change in stones were compared during and after stent placement for 6 months.
  
  
  RESULTS
  A total of 16 pigs were included (5 no coating, 5 0 % coating, 6 50 % coating). Biliary stones showed decreased weight in all groups; however, stones in the group with 50 % coated stents showed a greater reduction in weight compared with the no coating and the 0 % coating groups (269 ± 66 mg vs. 179 ± 51 mg [P = 0.09]; 269 ± 66 mg vs. 156 ± 26 mg [P = 0.01], respectively).
  
  
  CONCLUSIONS
  The plastic stent coated with 50 % agent enhanced CBD stone dissolution in vivo and may be a promising tool for patients with difficult biliary stones.
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Cai
authors.affiliation: Department of Endoscopy, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Wei Xing
authors.initials: WX
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Ru Ling
authors.initials: RL
authors.lastname: Zhang
authors.affiliation: Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Xiao
authors.initials: X
authors.lastname: Dong Yuan
authors.affiliation: College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of General Surgery, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xiao Shen
authors.initials: XS
authors.lastname: Qi
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Bai Wen
authors.initials: BW
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Qin Qian
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xing Peng
authors.initials: XP
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Lun Gen
authors.initials: LG
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Zheng Jie
authors.initials: ZJ
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xin Jian
authors.initials: XJ
authors.lastname: Wan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000681:Amylases / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D065096:Calcium Chelating Agents / Q000008:administration & dosage*; D002758:Cholangiography; D004195:Disease Models, Animal; D054855:Drug-Eluting Stents / Q000009:adverse effects; D004492:Edetic Acid / Q000008:administration & dosage*; D042882:Gallstones / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D007958:Leukocyte Count; D010969:Plastics; D020358:Sodium Cholate / Q000008:administration & dosage*; D013552:Swine
chemical_list: D065096:Calcium Chelating Agents; D010969:Plastics; D004492:Edetic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000681:Amylases; D020358:Sodium Cholate