title: Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells.
abstract: Ten new valepotriates, jatamanvaltrates P-Y (1-10) and a known one, nardostachin (11), have been isolated from the whole plants of Valeriana jatamansi. The structures of the new compounds were determined by detailed spectroscopic data analysis. The isolated compounds were evaluated for cytotoxic activity against PC-3M cells, and a structure-activity relationship was examined for all the valepotriates isolated from V. jatamansi. The results highlighted the structure-activity relationship importance of the C-3-C-4 double bond, the oxirane ring, and the 10-chlorine in the valepotriates.
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Longgang Central Hospital, ENT hospital of Longgang Central Hospital, Otolaryngology Institute of Shenzhen University, Otolaryngology Institute of Shenzhen, Shenzhen, Guangdong, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Su
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Zhong-Xiao
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship; D014632:Valerian / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D039823:Iridoids; C000600596:jatamanvaltrate P