title: Quantitative evaluation of hyaline articular cartilage T2 maps of knee and determine the relationship of cartilage T2 values with age, gender, articular changes.
abstract: OBJECTIVE
  To identify changes in knee joint cartilage transverse relaxation values depending on the patient's age and gender and to investigate the relationship between knee joint pathologies and the transverse relaxation time.
  
  
  METHODS
  Knee MRI images of 107 symptomatic patients with various pathologic knee conditions were analyzed retrospectively. T2 values were measured at patellar cartilage, posteromedial and posterolateral femoral cartilage adjacent to the central horn of posterior meniscus. 963 measurements were done for 107 knees MRI. Relationship of T2 values with seven features including subarticular bone marrow edema, subarticular cysts, marginal osteophytes, anterior-posterior cruciate and collateral ligament tears, posterior medial and posterior lateral meniscal tears, synovial thickening and effusion were analyzed. T2 values in all three compartments were evaluated according to age and gender.
  
  
  RESULTS
  A T2 value increase correlated with age was present in all three compartments measured in the subgroup with no knee joint pathology and in all patient groups. According to the ROC curve, an increase showing a statistically significant difference was present in the patient group aged over 40 compared to the patient group aged 40 and below in all patient groups. There is a statistically difference at T2 values with and without subarticular cysts, marginal osteophytes, synovial thickening and effusion. T2 relaxation time showed a statistically significant increase in the patients with a medial meniscus tear compared to those without a tear and no statistically significant difference was found in T2 relaxation times of patients with and without a posterior lateral meniscus tear.
  
  
  CONCLUSIONS
  T2 cartilage mapping on MRI provides opportunity to exhibit biochemical and structural changes related with cartilage extracellular matrix without using invasive diagnostic methods.
authors.affiliation: Department of Radiology, Ankara Oncology Research and Education Hospital, Ankara, Turkey. caglaremr41@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Cağlar
authors.forename: G
authors.initials: G
authors.lastname: Şahin
authors.forename: T
authors.initials: T
authors.lastname: Oğur
authors.forename: E
authors.initials: E
authors.lastname: Aktaş
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D051457:Hyaline Cartilage / Q000378:metabolism / Q000473:pathology; D007718:Knee Injuries / Q000175:diagnosis / Q000378:metabolism; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D008297:Male; D008592:Menisci, Tibial / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult