title: Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer.
abstract: The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Huiying
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Department of General Surgery , The Fourth Hospital of Hebei Medical University , Shijiazhuang , P.R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Fengbin
authors.initials: F
authors.lastname: Zhang
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of Gastroenterology and Hepatology and.
authors.forename: Ruixing
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004272:DNA, Mitochondrial; D004273:DNA, Neoplasm
keywords: D-Loop; SNPs; gastric cancer; mtDNA