title: Nanoparticle-Based Therapy in Genomics.
abstract: In the modern era, humankind is making daily progress through industrialization. As various types of diseases are prevailing worldwide, scientists are using many approaches to manage these diseases, such as gene therapy. A nanoparticle (NP)-based approach is an example of a modern method used to address several pathologies. This modern therapeutic approach aims not only at safely transferring the drug of choice to the site of interest in a biological system but also at ensuring the biocompatibility of these NPs. Hence, various coating methodologies are being employed to avoid NP toxicity as well as immunoreactivity. This short review covers the latest approaches and advances in this biomedical field. Among nanomaterials, gold NPs (GNPs) are comprehensively employed as a diagnostic tool for the treatment and management of diseases such as cancer.
authors.affiliation: Center of Excellence in Genomic Medicine Research (CEGMR), Post Box No. 80216, King Abdulaziz University, Jeddah, 21589 Saudi Arabia. mahmoodrasool@yahoo.com.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rasool
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.forename: Abdul
authors.initials: A
authors.lastname: Manan
authors.forename: Shakeel Ahmed
authors.initials: SA
authors.lastname: Ansari
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Naseer
authors.forename: Mahmood Husain
authors.initials: MH
authors.lastname: Qazi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Asif
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D015316:Genetic Therapy / Q000379:methods*; D023281:Genomics / Q000379:methods; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy
chemical_list: D006046:Gold