title: Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage.
abstract: Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS)-induced cell death and stimulate proliferation due to the antioxidative property of these particles.
authors.affiliation: Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University, Düsseldorf 40225, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: von Montfort
authors.affiliation: Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University, Düsseldorf 40225, Germany. Electronic address: alili@uni-duesseldorf.de.
authors.forename: Lirija
authors.initials: L
authors.lastname: Alili
authors.affiliation: Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University, Düsseldorf 40225, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Teuber-Hanselmann
authors.affiliation: Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University, Düsseldorf 40225, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Brenneisen
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002563:Cerium / Q000008:administration & dosage* / Q000009:adverse effects; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000517:prevention & control; D010084:Oxidation-Reduction / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000633:toxicity; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide
keywords: Cerium oxide; Fibroblasts; Redox-active nanoparticles; Skin cancer; Tumor–stroma interaction