title: Obesity at adolescence and gastric cancer risk.
abstract: OBJECTIVE
  During the last few decades, prevalence of obesity has risen rapidly worldwide, markedly in children and adolescents. Epidemiologic studies have associated obesity to several cancer types, yet little is known for the effect of early life exposure to obesity on cancer risk in later life, especially in gastric cancer. Thus, the present study aimed to investigate the association of body mass index (BMI) of adolescence and the risk of gastric cancer.
  
  
  METHODS
  A multicenter case-control study was conducted between 2010 and 2014 in Korea with 1,492 incident gastric cancer cases and 1,492 controls matched by age and sex. The BMI at age 18 was calculated by using weight and height from questionnaire. The association with the risk of gastric cancer was evaluated using odds ratios by logistic regression model adjusted for potential confounding factors.
  
  
  RESULTS
  Compared with BMI 21.75 kg/m(2), higher BMI at age 18 was associated with higher risk of gastric cancer showing a nonlinear, threshold effect. Statistically significant odds ratio was observed in men with BMI higher than 25.3 kg/m(2) (OR 1.13, 95 % CI 1.01-1.27) and in women with BMI 25.3 kg/m(2) and above (OR 1.25, 95 % CI 1.01-1.55).
  
  
  CONCLUSIONS
  Similar to some other cancer types, overweight or obese in adolescence was found to be associated with the increased risk of gastric cancer. The results imply for stratified approach of tactics in prevention of gastric cancer in different population.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, Republic of Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.|Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
authors.forename: Minkyo
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Ji-Yeob
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, Republic of Korea.|Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
authors.forename: Jae Jeong
authors.initials: JJ
authors.lastname: Yang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
authors.forename: Hyuna
authors.initials: H
authors.lastname: Sung
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, Republic of Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yunhee
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, Republic of Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hwi-Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.|Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Kong
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.|Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyuk-Joon
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.|Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, Republic of Korea. dhkang@snu.ac.kr.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. dhkang@snu.ac.kr.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. dhkang@snu.ac.kr.
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology; D015995:Prevalence; D056910:Republic of Korea; D012306:Risk; D012907:Smoking; D013274:Stomach Neoplasms / Q000150:complications* / Q000453:epidemiology*; D011795:Surveys and Questionnaires