title: Insight to the Epidemiology and Risk Factors of Extrapulmonary Tuberculosis in Tianjin, China during 2006-2011.
abstract: The proportion of extrapulmonary tuberculosis (EPTB) among all the reported tuberculosis (TB) cases has increased in different populations. Despite the large burden of TB in China, the epidemiology of EPTB in China remains largely understudied and the risk factors for having EPTB diagnosis in China have not been identified.
  
  
  
  To gain insight to EPTB epidemiology in China, we analyzed TB surveillance data collected in Tianjin, China, during 2006 to 2011. The frequency of EPTB among all TB cases and within different socio-demographic groups of the study patients aged 15 years and older was determined for EPTB in general and by specific types. The distribution of socio-demographic characteristics was compared between pulmonary TB (PTB) group and EPTB group by chi-square test. Crude and multiple logistic regression-derived adjusted odds ratios (aOR) and 95% confidence intervals (CI) were determined to assess the associations between having EPTB diagnosis and each individual explanatory variable in question.
  
  
  
  About one-tenth (1,512/14,561) of the patients investigated in this study had EPTB. Of these 1,512 EPTB cases, about two thirds were pleural TB. Significant difference in age, occupation, and urbanity of residence were found between PTB and EPTB groups (p<0.05). Patients with EPTB diagnosis were more likely to be 65 years or older (aOR = 1.22, 95% CI: 1.02, 1.46), to be retired (aOR = 1.37, 95% CI: 1.08, 1.75), and to live in urban areas (aOR = 1 38, 95% CI: 1.22, 1.55).
  
  
  
  The findings of this study extends the knowledgebase of EPTB epidemiology in developing countries and highlight the need for improved EPTB detection in China, especially in subpopulations with high risk for EPTB or having limited access to medical facilities with adequate capacity for EPTB diagnosis.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Tuberculosis Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Tuberculosis Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
authors.forename: Guoqin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Tuberculosis Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Tuberculosis Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tuberculosis Institute, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
authors.forename: Xiexiu
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China / Q000453:epidemiology; D003906:Developing Countries; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D014376:Tuberculosis / Q000453:epidemiology*; D014505:Urban Population; D055815:Young Adult