title: Koschei the immortal and anti-aging drugs.
abstract: In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.
authors.affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Blagosklonny
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D031204:Caloric Restriction; D015444:Exercise; D005495:Folklore; D015870:Gene Expression; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008687:Metformin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012426:Russia; D020123:Sirolimus / Q000494:pharmacology*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D008687:Metformin; D011433:Propranolol; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D005947:Glucose; D001241:Aspirin; D020123:Sirolimus