title: Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia--a study from Southern India.
abstract: The present study was undertaken to validate the measurement of biomarkers as a supplement to the latest diagnostic criteria for Alzheimer disease (AD) dementia by National Institute on Aging-Alzheimer's Association (NIA-AA) work group using a sample attending a tertiary care center in Southern India. A total of 20 subjects diagnosed clinically as Alzheimer's dementia according to the NIA-AA criteria for AD were included in the study. The CSF biomarkers Aβ42, t-tau, and p-tau181 were assessed. The biomarker results were compared among mild and moderate to severe AD as defined in the NIA-AA work group guidelines. The results revealed that the amount of Aβ42 was very low in all the 20 samples (<50pg/ml) collected from mild AD cases with CDR score of 1 (n=8), and moderate to severe AD cases with CDR >1 (n=12). t-tau and p-tau levels were in the range of 39.45±5.09pg/ml and 13.06±7.32pg/ml for CDR 1 group. t-tau and p-tau levels were in the range of 49.9±11.28pg/ml and 33.94±15.13pg/ml for moderate to severe cases. Analysis of the data revealed statistically significant differences in the p-tau/t-tau ratio and p-tau/Aβ ratio between CDR 1and CDR >1 AD cases (p<0.001) suggesting that p-tau/t-tau and p-tau/Aβ ratio are good indicators of severity of dementia with discriminative value in differentiating mild AD from moderate to severe AD.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Chandrashekar B
authors.initials: CB
authors.lastname: Huded
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Srikala
authors.initials: S
authors.lastname: Bharath
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Chandra
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: P T
authors.initials: PT
authors.lastname: Sivakumar
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Mathew
authors.initials: M
authors.lastname: Varghese
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Bangalore, India. Electronic address: sarada@nimhans.kar.nic.in.
authors.forename: Sarada
authors.initials: S
authors.lastname: Subramanian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D054561:National Institute on Aging (U.S.); D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D014481:United States; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Alzheimer disease; Amyloid β; Biomarker; Cerebrospinal fluid; Tau