title: A session of resistance exercise increases vasodilation in intermittent claudication patients.
abstract: No study has shown the effects of acute resistance exercise on vasodilatory capacity of patients with peripheral artery disease. The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease. Fourteen peripheral artery disease patients underwent, in a random order, 2 experimental sessions: control (rest for 30 min) and resistance exercise (8 exercises, 2 sets of 10 repetitions at an intensity of 5-7 in the OMNI Resistance Exercise Scale). Blood flow, reactive hyperemia, plasma nitrite, and malondialdehyde were measured before and 40 min after the interventions in both sessions. Data were compared between sessions by analysis of covariance, using pre-intervention values as covariates. The increases in blood flow, reactive hyperemia, and log plasma nitrite were greater (p ≤ 0.05) after resistance exercise than the control session (3.2 ± 0.1 vs. 2.7 ± 0.1 mL · 100 mL(-1) tissue · min(-1), 8.0 ± 0.1 vs. 5.7 ± 0.1 AU, and 1.36 ± 0.01 vs. 1.26 ± 0.01 μmol ∙ L(-1), respectively). On the other hand, malondialdehyde was similar between sessions (p > 0.05). In peripheral arterial disease patients, a single session of resistance exercise increases blood flow and reactive hyperemia, which seems to be mediated, in part, by increases in nitric oxide release.
authors.affiliation: a School of Physical Education, University of Pernambuco, Rua Arnóbio Marques, 310, Recife, Pernambuco 50.100-130, Brazil.
authors.forename: Aluísio
authors.initials: A
authors.lastname: Lima
authors.forename: Raphael
authors.initials: R
authors.lastname: Ritti-Dias
authors.forename: Cláudia L M
authors.initials: CL
authors.lastname: Forjaz
authors.forename: Marilia
authors.initials: M
authors.lastname: Correia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Miranda
authors.forename: Maria
authors.initials: M
authors.lastname: Brasileiro-Santos
authors.forename: Amilton
authors.initials: A
authors.lastname: Santos
authors.forename: Dario
authors.initials: D
authors.lastname: Sobral Filho
authors.forename: Alexandre
authors.initials: A
authors.lastname: Silva
mesh_terms: D000368:Aged; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007383:Intermittent Claudication / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D055806:Microvessels / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood / Q000378:metabolism; D058729:Peripheral Arterial Disease / Q000503:physiopathology; D012039:Regional Blood Flow; D055070:Resistance Training / Q000009:adverse effects; D014664:Vasodilation
chemical_list: D009573:Nitrites; D009569:Nitric Oxide; D008315:Malondialdehyde
keywords: exercice de force; maladie artérielle périphérique; microvascular reactivity; oxidative stress; peripheral artery disease; réactivité microvasculaire; strength exercise; stress oxydatif