title: Prediction of neonatal respiratory distress syndrome in term pregnancies by assessment of fetal lung volume and pulmonary artery resistance index.
abstract: OBJECTIVE
  To develop reference cutoff values for mean fetal lung volume (FLV) and pulmonary artery resistance index (PA-RI) for prediction of neonatal respiratory distress syndrome (RDS) in low-risk term pregnancies.
  
  
  METHODS
  As part of a cross-sectional study, women aged 20-35 years were enrolled and admitted to a tertiary hospital in Cairo, Egypt, for elective repeat cesarean at 37-40 weeks of pregnancy between January 1, 2012, and July 31, 2013. FLV was calculated by virtual organ computer-aided analysis, and PA-RI was measured by Doppler ultrasonography before delivery.
  
  
  RESULTS
  A total of 80 women were enrolled. Neonatal RDS developed in 11 (13.8%) of the 80 newborns. Compared with neonates with RDS, healthy neonates had significantly higher FLVs (P<0.001) and lower PA-RIs (P<0.001). Neonatal RDS is less likely with FLV of at least 32 cm(3) or PA-RI less than or equal to 0.74. Combining these two measures improved the accuracy of prediction.
  
  
  CONCLUSIONS
  The use of either FLV or PA-RI predicted neonatal RDS. The predictive value increased when these two measures were combined.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: laban63@yahoo.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Laban
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Ghada M
authors.initials: GM
authors.lastname: Mansour
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Mohammed S E
authors.initials: MS
authors.lastname: Elsafty
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Alaa S
authors.initials: AS
authors.lastname: Hassanin
authors.affiliation: Early Cancer Detection Unit, Ain Shams Maternity Hospital, Cairo, Egypt.
authors.forename: Sahar S
authors.initials: SS
authors.lastname: EzzElarab
mesh_terms: D000328:Adult; D017604:Cesarean Section, Repeat; D003430:Cross-Sectional Studies; D004534:Egypt; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D008176:Lung Volume Measurements / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D011651:Pulmonary Artery / Q000196:embryology*; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000503:physiopathology*; D018608:Ultrasonography, Doppler / Q000379:methods; D014655:Vascular Resistance / Q000502:physiology; D055815:Young Adult
keywords: Fetal lung volume; Fetal pulmonary artery Doppler; Neonatal respiratory distress syndrome; Pulmonary artery resistance index; Three-dimensional ultrasonography; Virtual organ computer-aided analysis