title: Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy.
abstract: Radiation therapy undeniably enhances local control and thus improves overall survival in cancer patients. However, some long-term cancer survivors (less than 10%) develop severe late radio-induced toxicities altering their quality of life. Therefore, there is a need to identify patients who are sensitive to those toxicities and who could benefit from adapted care. In this review, we address all available techniques aiming to detect patients' hyper-radiosensitivity and present the scientific rationales these techniques are based on.
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; Institut régional du Cancer de Montpellier (ICM) - Val d'Aurelle, Department of Radiotherapy, Montpellier, France. Electronic address: celine.bourgier@icm.unicancer.fr.
authors.forename: Céline
authors.initials: C
authors.lastname: Bourgier
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lacombe
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; CHU Montpellier, Arnaud de Villeneuve Hospital, Department of Cellular Biology, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Solassol
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Mange
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.
authors.forename: André
authors.initials: A
authors.lastname: Pèlegrin
authors.affiliation: CHUV Lausanne, Service de Radio-Oncologie, CH-1011 Lausanne, Switzerland.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozsahin
authors.affiliation: University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; Institut régional du Cancer de Montpellier (ICM) - Val d'Aurelle, Department of Radiotherapy, Montpellier, France.
authors.forename: David
authors.initials: D
authors.lastname: Azria
mesh_terms: D015415:Biomarkers; D009369:Neoplasms / Q000150:complications* / Q000401:mortality / Q000532:radiotherapy; D057285:Precision Medicine; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D017741:Survivors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Predictive markers; Radiotherapy outcome