title: The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis.
abstract: OBJECTIVE
  Fatty pancreas (FP) is related to obesity, and may have some clinical implications on glucose metabolism. The frequency and importance of FP in patients with nonalcoholic steatohepatitis (NASH) are not clear. This study aimed to investigate: the frequency of FP in patients with NASH, and its effects on serum glucose parameters.
  
  
  METHODS
  FP was detected and graded by transabdominal ultrasonography (USG) in patients with biopsy-proven NASH and healthy controls. Body Mass Index and waist circumference were recorded, and serum lipids, fasting serum glucose, HbA1c, OGTT 2-h, insulin level, insulin resistance, type 2 diabetes mellitus (DM) and prediabetes rates were detected.
  
  
  RESULTS
  Eighty-four subjects with NASH and 35 healthy controls were enrolled in the study. There was no FP in 41 (48.8%) of the NASH patients according to the study criteria. Forty-three of the NASH patients and 5 of the controls had different grades of fat in their pancreas (51.2% vs. 14%, p=0.001). The HbA1c and OGTT 2-h results were significantly higher in NASH patients with FP compared to those without FP (p=0.003 and p=0.018). The rates of both prediabetes and DM were also found to be significantly increased in NASH patients with FP (p=0.004). The mean waist circumference was higher in patients with FP (p=0.027). Grade of FP by USG showed no effect on study parameters in subgroup analysis.
  
  
  CONCLUSIONS
  FP is common in patients with NASH and increases the rate of prediabetes and DM. The coexistence of both NASH and FP has a further impact on glucose metabolism and DM frequency.
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uygun
authors.affiliation: Division of Gastroenterology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: kadayifci@hotmail.com.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kadayifci
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Demirci
authors.affiliation: Department of Radiology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Saglam
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Yusuf S
authors.initials: YS
authors.lastname: Sakin
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Ozturk
authors.affiliation: Division of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Zulfikar
authors.initials: Z
authors.lastname: Polat
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Karslioglu
authors.affiliation: Division of Endocrinology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Bolu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000378:metabolism; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism; D011236:Prediabetic State / Q000453:epidemiology* / Q000378:metabolism; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human
keywords: Diabetes mellitus; Fatty pancreas; Glucose; Nonalcoholic steatohepatitis; Prediabetes