title: Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy.
abstract: The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology is developed to construct a multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T1-weighted magnetic resonance imaging (MRI), X-ray computed tomography (CT) imaging, photothermal therapy (PTT), and chemotherapy, into one single nanoprobe (named as UCNP@PDA5-PEG-DOX). For generating the UCNP@PDA5-PEG-DOX, a near-infrared light (NIR)-absorbing polydopamine (PDA) shell is directly coated on oleic-acid-capped β-NaGdF4:Yb(3+),Er(3+)@β-NaGdF4 upconverting nanoparticle (UCNP) core for the first time to form monodisperse, ultrastable, and noncytotoxic core-shell-structured nanosphere via water-in-oil microemulsion approach. When combined with 808 nm NIR laser irradiation, the UCNP@PDA5-PEG-DOX shows great synergistic interaction between PTT and the enhanced chemotherapy, resulting in completely eradicated mouse-bearing SW620 tumor without regrowth. In addition, leakage study, hemolysis assay, histology analysis, and blood biochemistry assay unambiguously reveal that the UCNP@PDA5-PEG has inappreciable cytotoxicity and negligible organ toxicity. The results provide explicit strategy for fabricating multifunctional nanoplatforms from the integration of UCNP with NIR-absorbing polymers, important for developing multi-mode nanoprobes for biomedical applications.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China; University of Chinese Academy of Sciences, Beijing, 100039, P.R. China.
authors.forename: Fuyao
authors.initials: F
authors.lastname: Liu
authors.forename: Xiuxia
authors.initials: X
authors.lastname: He
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lei
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
authors.forename: Hongpeng
authors.initials: H
authors.lastname: You
authors.forename: Huimao
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D004357:Drug Synergism; D004358:Drug Therapy; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D051379:Mice; D064847:Multimodal Imaging; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D019265:Spectroscopy, Near-Infrared; D013696:Temperature; D014057:Tomography, X-Ray Computed
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: chemotherapy; multimodality imaging; photothermal therapy; polydopamine; upconversion nanoparticle