title: Resting-state functional connectivity alterations in the default network of schizophrenia patients with persistent auditory verbal hallucinations.
abstract: To understand the neural mechanism that underlies treatment resistant auditory verbal hallucinations (AVH), is still an important issue in psychiatric research. Alterations in functional connectivity during rest have been frequently reported in patients with schizophrenia. Though the default mode network (DN) appears to be abnormal in schizophrenia patients, little is known about its role in resistant AVH. We collected resting-state functional magnetic resonance imaging (R-fMRI) data with a 3T scanner from 19 schizophrenia patients with chronic AVH resistant to pharmacological treatment, 14 schizophrenia patients without AVH and 20 healthy controls. Using seed-based correlation analysis, we created spherical seed regions of interest (ROI) to examine functional connectivity of the two DN hub regions (posterior cingulate cortex and anteromedial prefrontal cortex) and the two DN subsystems: dorsomedial prefrontal cortex subsystem and medial temporal lobe subsystem (p<0.0045 corrected). Patients with hallucinations exhibited higher FC between dMPFC ROI and bilateral central opercular cortex, bilateral insular cortex and bilateral precentral gyrus compared to non hallucinating patients and healthy controls. Additionally, patients with hallucinations also exhibited lower FC between vMPFC ROI and bilateral paracingulate and dorsal anterior cingulate cortex. As the anterior cingulate cortex and the insula are two hubs of the salience network, our results suggest cross-network abnormalities between DN and salience system in patients with persistent hallucinations.
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Electronic address: aalonsos@santpau.cat.
authors.forename: Anna
authors.initials: A
authors.lastname: Alonso-Solís
authors.affiliation: Port d'Informació Científica (PIC), Universitat Autònoma de Barcelona (UAB), Institut de Física d'Altes Energies (IFAE), Barcelona, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Vives-Gilabert
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM.
authors.forename: Eva
authors.initials: E
authors.lastname: Grasa
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Portella
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Rabella
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM; Centre de Salut Mental d'Adults d'Horta (CSMA), Barcelona, Spain.
authors.forename: Rosa Blanca
authors.initials: RB
authors.lastname: Sauras
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Roldán
authors.affiliation: Department of Neuroradiology, Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: Fidel
authors.initials: F
authors.lastname: Núñez-Marín
authors.affiliation: Department of Neuroradiology, Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Gómez-Ansón
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM; Servei de Psiquiatria Parc de Salut Mar, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Pérez
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM.
authors.forename: Enric
authors.initials: E
authors.lastname: Alvarez
authors.affiliation: Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM.
authors.forename: Iluminada
authors.initials: I
authors.lastname: Corripio
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D001931:Brain Mapping; D005260:Female; D006212:Hallucinations / Q000150:complications / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012146:Rest; D012559:Schizophrenia / Q000150:complications / Q000473:pathology
chemical_list: D010100:Oxygen
keywords: Auditory verbal hallucinations; Default mode network; Resting state functional connectivity; Salience network