title: Towards the elaboration of new gold-based optical theranostics.
abstract: Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue Alain Savary, BP 47870, 21080 Dijon Cedex, France. ewen.bodio@u-bourgogne.fr christine.goze@u-bourgogne.fr.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Doulain
authors.forename: Richard
authors.initials: R
authors.lastname: Decréau
authors.forename: Cindy
authors.initials: C
authors.lastname: Racoeur
authors.forename: Victor
authors.initials: V
authors.lastname: Goncalves
authors.forename: Laurence
authors.initials: L
authors.lastname: Dubrez
authors.forename: Ali
authors.initials: A
authors.lastname: Bettaieb
authors.forename: Pierre
authors.initials: P
authors.lastname: Le Gendre
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
authors.forename: Catherine
authors.initials: C
authors.lastname: Paul
authors.forename: Christine
authors.initials: C
authors.lastname: Goze
authors.forename: Ewen
authors.initials: E
authors.lastname: Bodio
mesh_terms: D001692:Biological Transport; D001839:Bombesin / Q000378:metabolism; D001896:Boron Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D061848:Optical Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D009942:Organometallic Compounds; D006046:Gold; D001839:Bombesin