title: Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis.
abstract: The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
authors.affiliation: Department of Gynecology, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Sun
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Chen
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Xie
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Du
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Xu-Liang
authors.initials: XL
authors.lastname: Shen
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wu
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2