title: Aflibercept-related nasal septum perforation.
abstract: Hypertension, cytopenia and diarrhea are the most common side effects of aflibercept. Rarely thromboembolism, hemorrhage, fistulization and reversible posterior leukoencephalopathy have been reported. Here we report a patient experiencing nasal septum perforation during aflibercept therapy.
authors.affiliation: Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Alkan
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Yücel
authors.affiliation: Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Dılşa
authors.initials: D
authors.lastname: Mızrak
authors.affiliation: Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Akbulut
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D061270:Nasal Septal Perforation / Q000209:etiology*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011993:Recombinant Fusion Proteins; C533178:aflibercept; D040262:Receptors, Vascular Endothelial Growth Factor