title: Relation of myeloperoxidase-463G/A polymorphism with metabolic syndrome and its component traits in Egyptian women.
abstract: BACKGROUND
  Myeloperoxidase is a heme protein secreted by activated macrophages and generates intermediates that oxidize lipoproteins. Myeloperoxidase-463G/A is a functional polymorphism involved in regulation of myeloperoxidase expression.
  
  
  OBJECTIVE
  The aim of this study is to assess the relation of myeloperoxidase-463G/A polymorphism with metabolic syndrome and its component traits in Egyptian women from the Suez Canal area.
  
  
  METHODS
  The study includes 100 healthy female subjects and 100 metabolic syndrome patients. The component traits of metabolic syndrome are determined and the genotypes of the polymorphisms assessed using the PCR-RFLP technique.
  
  
  RESULTS
  There was no significant difference in the allele frequencies between the metabolic syndrome and control groups. However, the GA and AA genotypes were associated with lower total cholesterol, LDL-C, systolic and diastolic blood pressure in the patients.
  
  
  CONCLUSIONS
  Myeloperoxidase-463G/A polymorphism is not associated with the incidence of metabolic syndrome.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt and.
authors.forename: Eman T
authors.initials: ET
authors.lastname: Mehanna
authors.forename: Samy M
authors.initials: SM
authors.lastname: Saleh
authors.forename: Maivel H
authors.initials: MH
authors.lastname: Ghattas
authors.forename: Noha M
authors.initials: NM
authors.lastname: Mesbah
authors.forename: Dina M
authors.initials: DM
authors.lastname: Abo-Elmatty
mesh_terms: D000328:Adult; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004534:Egypt; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D024821:Metabolic Syndrome / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D009195:Peroxidase
keywords: HDL; LDL; Peroxidase; lipoproteins