title: Cost-effectiveness of larviciding for urban malaria control in Tanzania.
abstract: BACKGROUND
  Larviciding for malaria control can contribute to an Integrated Vector Management (IVM) approach. This intervention is currently supported in settings where breeding habitats are 'few, fixed, and findable', such as urban areas of sub-Saharan Africa, but the knowledge base regarding the cost-effectiveness of larviciding is non-existent.
  
  
  METHODS
  Programme costs and effectiveness data were collected from the Dar es Salaam Urban Malaria Control Programme in Tanzania. Cost-effectiveness ratios (CER) were estimated from the provider and societal perspectives for standard indicators using different malaria transmission scenarios.
  
  
  RESULTS
  CER for microbial larviciding were highly dependent on the assumed baseline malaria incidence rates. Using the societal perspective, net CER were estimated (in 2012 US dollars) at $43 (95% uncertainty intervals [UI]: $15-181) per disability-adjusted life year averted (DALY) when malaria incidence was 902 infections per 1,000 individuals, increasing to $545 (95% UI: $337-1,558) per DALY at an incidence of 122 per 1,000. Larviciding was shown to be cost-effective in Tanzania for incidences as low as 40 infections per 1,000 people per year.
  
  
  CONCLUSIONS
  This is believed to be the first study to estimate the cost-effectiveness of larviciding for urban malaria control in sub-Saharan Africa. The results support the use of larviciding as a cost-effective intervention in urban areas and managers of national malaria control programme should consider this intervention as part of an IVM approach.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Maheu-Giroux
authors.affiliation: Department of Global Health & Population, Harvard School of Public Health, Boston, MA, USA. mcastro@hsph.harvard.edu.
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Castro
mesh_terms: D003362:Cost-Benefit Analysis; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D006801:Humans; D007306:Insecticides / Q000008:administration & dosage* / Q000191:economics*; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission*; D009032:Mosquito Control / Q000191:economics* / Q000379:methods*; D013636:Tanzania; D014505:Urban Population
chemical_list: D007306:Insecticides