title: The acute effects of exercise on cortical excitation and psychosocial outcomes in men treated for prostate cancer: a randomized controlled trial.
abstract: OBJECTIVE
  Regular exercise improves psychological well-being in men treated for prostate cancer (PCa). For this population and among cancer survivors in general, the effect of a single bout of exercise on self-report or objective measures of psychological well-being has not been examined. We examined the acute effect of a single bout of exercise on the cortical silent period (CSP) and on self-reported mood in men that have received treatment for PCa.
  
  
  METHODS
  Thirty-six PCa survivors were randomly assigned to 60 min of low to moderate intensity exercise or to a control condition. Outcomes were assessed immediately before and after either the exercise or the control condition.
  
  
  RESULTS
  No significant between-group differences were observed in CSP or mood were observed following the exercise session or control conditions. Participants with higher scores of trait anxiety had significantly shorter CSP at baseline, as well as those receiving androgen deprivation therapy. Age and baseline CSP had a low-moderate, but significant negative correlation. Changes in CSP following the exercise condition were strongly negatively correlated with changes in self-reported vigor.
  
  
  CONCLUSIONS
  While we did not observe any acute effect of exercise on the CSP in this population, the associations between CSP and trait anxiety, age, and vigor are novel findings requiring further examination.
  
  
  CONCLUSIONS
  Exercise did not acutely affect our participants in measures of psychological well-being. Additional mechanisms to explain the chronic psychosocial benefits of exercise previously observed in men with PCa require further exploration. Clinicaltrials.gov Identifier: NCT01715064 (http://clinicaltrials.gov/show/NCT01715064).
authors.affiliation: Kinesiology Program, University of Guelph-Humber Toronto, ON, Canada ; Prostate Centre - Princess Margaret Cancer Centre Toronto, ON, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Santa Mina
authors.affiliation: School of Kinesiology and Health Science, York University Toronto, ON, Canada.
authors.forename: Crissa L
authors.initials: CL
authors.lastname: Guglietti
authors.affiliation: Centre for Addiction and Mental Health Toronto, ON, Canada ; University of Toronto Toronto, ON, Canada.
authors.forename: Danilo R
authors.initials: DR
authors.lastname: de Jesus
authors.affiliation: School of Kinesiology and Health Science, York University Toronto, ON, Canada.
authors.forename: Saam
authors.initials: S
authors.lastname: Azargive
authors.affiliation: Prostate Centre - Princess Margaret Cancer Centre Toronto, ON, Canada ; University of Toronto Toronto, ON, Canada.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Matthew
authors.affiliation: University of Toronto Toronto, ON, Canada ; University Health Network Toronto, ON, Canada.
authors.forename: Shabbir M H
authors.initials: SM
authors.lastname: Alibhai
authors.affiliation: Prostate Centre - Princess Margaret Cancer Centre Toronto, ON, Canada ; University of Toronto Toronto, ON, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg
authors.affiliation: Centre for Addiction and Mental Health Toronto, ON, Canada ; University of Toronto Toronto, ON, Canada.
authors.forename: Jeffrey Z
authors.initials: JZ
authors.lastname: Daskalakis
authors.affiliation: School of Kinesiology and Health Science, York University Toronto, ON, Canada ; Cancer Care Ontario Toronto, ON, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Ritvo
keywords: anxiety; cortical silent period; depression; physical activity; prostate cancer; randomized controlled trial