title: Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment.
abstract: The combination of a multi-therapeutic mode with a controlled fashion is a key improvement in nanomedicine. Here, we synthesized polyethylene glycol (PEG)-modified doxorubicin (DOX)-loaded mesoporous silica nanoparticle (MSN) @CuS nanohybrids as efficient drug delivery carriers, combined with photothermal therapy and chemotherapy to enhance the therapeutic efficacy on hepatocellular carcinoma (HCC). The physical properties of the nanohybrids were characterized by transmission electron microscopy (TEM), N2 adsorption and desorption experiments and by the Vis-NIR absorption spectra. The results showed that the doxorubicin could be stored in the inner pores of mesoporous silica nanoparticles; the CuS nanoparticles, which are coated on the surface of a mesoporous silica nanoparticle, could serve as efficient photothermal therapy (PTT) agents; the loaded drug release could be easily triggered by NIR irradiation. The combination of the PTT treatment with controlled chemotherapy could further enhance the cancer ablation ability compared to any of the single approaches alone. Hence, the reported PEG-modified DOX-loaded mesoporous silica nanoparticle@CuS nanohybrids might be very promising therapeutic agents for HCC treatment.
authors.affiliation: The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, People's Republic of China. The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, People's Republic of China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Da
authors.initials: D
authors.lastname: Zhang
authors.forename: Aixian
authors.initials: A
authors.lastname: Zheng
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liu
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D065546:Drug Liberation; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007834:Lasers; D008113:Liver Neoplasms / Q000188:drug therapy*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D013696:Temperature
chemical_list: D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide