title: Altered fractionation schedules in radiation treatment: a review.
abstract: Conventionally fractionated radiotherapy is delivered in 1.8- to 2.0-Gy fractions. With increases in understanding of radiation and tumor biology, various alterations of radiotherapy schedules have been tested in clinical trials and are now regarded by some as standard treatment options. Hyperfractionation is delivered through a greater number of smaller treatment doses. Accelerated fractionation decreases the amount of time over which radiotherapy is delivered typically by increasing the number of treatments per day. Hypofractionation decreases the number of fractions delivered by increasing daily treatment doses. Furthermore, many of these schedules have been tested with concurrent chemotherapy regimens. In this review, we summarize the major clinical studies that have been conducted on altered fractionation in various disease sites.
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Kamran A
authors.initials: KA
authors.lastname: Ahmed
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Candace R
authors.initials: CR
authors.lastname: Correa
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Dilling
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Nikhil G
authors.initials: NG
authors.lastname: Rao
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Ravi
authors.initials: R
authors.lastname: Shridhar
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Andy M
authors.initials: AM
authors.lastname: Trotti
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Wilder
authors.affiliation: Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. Electronic address: jimmy.caudell@moffitt.org.
authors.forename: Jimmy J
authors.initials: JJ
authors.lastname: Caudell
mesh_terms: D000818:Animals; D019583:Dose Fractionation, Radiation; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*