title: Unusual cause of aborted sudden cardiac death in a teen athlete: homozygosity for the 4G allele of the plasminogen activase inhibitor type 1 gene.
abstract: Common aetiologies of sudden cardiac death in children include coronary anomalies, channelopathies, and cardiomyopathies. Less frequently, hypercoagulable states cause sudden arrest. We report an unusual case of aborted sudden cardiac death in a teenager, ultimately found to have homozygosity for the 4G allele of the plasminogen activase inhibitor type 1 gene.
authors.affiliation: 1Department of Pediatrics,Children's Heart Center,Children's of Mississippi,University of Mississippi Medical Center,Jackson,Mississippi,United States of America.
authors.forename: Susie B
authors.initials: SB
authors.lastname: Phillips
authors.affiliation: 2Department of Pediatrics,Children's Heart Center,Division of Cardiology,Children's of Mississippi,University of Mississippi Medical Center,Jackson,Mississippi,United States of America.
authors.forename: Sarosh
authors.initials: S
authors.lastname: Batlivala
authors.affiliation: 3Department of Pediatrics,Children's Heart Center,Division of Critical Care,Children's of Mississippi,University of Mississippi Medical Center,Jackson,Mississippi,United States of America.
authors.forename: Jarrod D
authors.initials: JD
authors.lastname: Knudson
mesh_terms: D000293:Adolescent; D000483:Alleles; D001241:Aspirin / Q000627:therapeutic use; D056352:Athletes; D006328:Cardiac Catheterization / Q000379:methods; D000077144:Clopidogrel; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006720:Homozygote; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000235:genetics*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
keywords: Sudden cardiac death; coronary ischaemia; plasminogen activase inhibitor