title: Potential lung nodules identification for characterization by variable multistep threshold and shape indices from CT images.
abstract: Computed tomography (CT) is an important imaging modality. Physicians, surgeons, and oncologists prefer CT scan for diagnosis of lung cancer. However, some nodules are missed in CT scan. Computer aided diagnosis methods are useful for radiologists for detection of these nodules and early diagnosis of lung cancer. Early detection of malignant nodule is helpful for treatment. Computer aided diagnosis of lung cancer involves lung segmentation, potential nodules identification, features extraction from the potential nodules, and classification of the nodules. In this paper, we are presenting an automatic method for detection and segmentation of lung nodules from CT scan for subsequent features extraction and classification. Contribution of the work is the detection and segmentation of small sized nodules, low and high contrast nodules, nodules attached with vasculature, nodules attached to pleura membrane, and nodules in close vicinity of the diaphragm and lung wall in one-go. The particular techniques of the method are multistep threshold for the nodule detection and shape index threshold for false positive reduction. We used 60 CT scans of "Lung Image Database Consortium-Image Database Resource Initiative" taken by GE medical systems LightSpeed16 scanner as dataset and correctly detected 92% nodules. The results are reproducible.
authors.affiliation: CEME, National University of Science and Technology, Islamabad 46000, Pakistan.
authors.forename: Saleem
authors.initials: S
authors.lastname: Iqbal
authors.affiliation: CEME, National University of Science and Technology, Islamabad 46000, Pakistan.
authors.forename: Khalid
authors.initials: K
authors.lastname: Iqbal
authors.affiliation: MCS, National University of Science and Technology, Islamabad 46000, Pakistan.
authors.forename: Fahim
authors.identifier: 0000-0002-5361-8600
authors.initials: F
authors.lastname: Arif
authors.affiliation: CEME, National University of Science and Technology, Islamabad 46000, Pakistan.
authors.forename: Arslan
authors.initials: A
authors.lastname: Shaukat
authors.affiliation: CEME, National University of Science and Technology, Islamabad 46000, Pakistan.
authors.forename: Aasia
authors.initials: A
authors.lastname: Khanum
mesh_terms: D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008962:Models, Theoretical; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*