title: Safety and prolonged efficacy of Botulin Toxin A in primary hyperhidrosis.
abstract: BACKGROUND
  Hyperhidrosis is a condition characterized by generalized or localized hyperfunction of the eccrine sweat glands with a deep negative impact on patient's quality of life.
  
  
  OBJECTIVE
  To evaluate the efficacy and the safety of Botulin Toxin A (BTX-A) intradermal injection in the treatment of primary axillary and palmar hyperhidrosis, investigating symptoms-free period, and the subjective improving of quality life.
  
  
  METHODS
  50 consecutive patients with primary hyperhidrosis were evaluated detecting age, gender, hyperhidrosis onset period, disease duration and years of treatment with BTX-A, Minor's iodine test, Hyperhidrosis Disease Severity Scale (HDSS), Dermatology Life Quality Index (DLQI).
  
  
  RESULTS
  The treatment is significantly effective both for axillae and palms: the majority of the patients improved their HDSS and Minor's scores from a value of 4 in the two tests, to values of 1 (HDSS) and 0 (Minor test). Patients reported a duration of symptoms relief from 4 to 12 months, with a mean of 5.68 months; specifically, we have observed that the axillary group experienced a longer symptoms-free period (mean RFS 7.2 months) than the palmar group (mean: RFS 4.27 months).
  
  
  CONCLUSIONS
  Authors suggest that BTX-A is a safe, easy, and fast procedure for the treatment of primary axillary and palmar hyperhidrosis.
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: D'Epiro
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Macaluso
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Salvi
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Luci
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mattozzi
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Marzocca
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Salvo
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Scarnò
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
authors.affiliation: Dermatology Clinic, 'Sapienza' University of Rome, Italy.
authors.forename: A G
authors.initials: AG
authors.lastname: Richetta
mesh_terms: D000328:Adult; D001365:Axilla; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy* / Q000523:psychology; D007271:Injections, Intradermal; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011788:Quality of Life; D012720:Severity of Illness Index
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A
keywords: Axillary hyperhidrosis; Botulinum toxin; Palmar hyperhidrosis