title: Acute necrotizing pancreatitis: Surgical indications and technical procedures.
abstract: Necrosis of pancreatic parenchyma or extrapancreatic tissues is present in 10%-20% of patients with acute pancreatitis, defining the necrotizing presentation frequently associated with high morbidity and mortality rates. During the initial phase of acute necrotizing pancreatitis the most important pillars of medical treatment are fluid resuscitation, early enteral nutrition, endoscopic retrograde colangiopancreatography if associated cholangitis and intensive care unit support. When infection of pancreatic or extrapancreatic necrosis occurs, surgical approach constitutes the most accepted therapeutic option. In this context, we have recently assited to changes in time for surgery (delaying the indication if possible to around 4 wk to deal with "walled-off" necrosis) and type of access for necrosectomy: from a classical open approach (with closure over large-bore drains for continued postoperative lavage or semiopen techniques with scheduled relaparotomies), trends have changed to a "step-up" philosophy with initial percutaneous drainage and posterior minimally invasive or endoscopic access to the retroperitoneal cavity for necrosectomy if no improvement has been previously achieved. These approaches are progressively gaining popularity and morbidity and mortality rates have decreased significantly. Therefore, a staged, multidisciplinary, step-up approach with minimally invasive or endoscopic access for necrosectomy is widely accepted nowadays for management of pancreatic necrosis.
authors.affiliation: José Manuel Aranda-Narváez, Antonio Jesús González-Sánchez, María Custodia Montiel-Casado, Alberto Titos-García, Julio Santoyo-Santoyo, General, Digestive and Transplantation Surgery Department, University Regional Hospital, 29010 Málaga, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Aranda-Narváez
authors.affiliation: José Manuel Aranda-Narváez, Antonio Jesús González-Sánchez, María Custodia Montiel-Casado, Alberto Titos-García, Julio Santoyo-Santoyo, General, Digestive and Transplantation Surgery Department, University Regional Hospital, 29010 Málaga, Spain.
authors.forename: Antonio Jesús
authors.initials: AJ
authors.lastname: González-Sánchez
authors.affiliation: José Manuel Aranda-Narváez, Antonio Jesús González-Sánchez, María Custodia Montiel-Casado, Alberto Titos-García, Julio Santoyo-Santoyo, General, Digestive and Transplantation Surgery Department, University Regional Hospital, 29010 Málaga, Spain.
authors.forename: María Custodia
authors.initials: MC
authors.lastname: Montiel-Casado
authors.affiliation: José Manuel Aranda-Narváez, Antonio Jesús González-Sánchez, María Custodia Montiel-Casado, Alberto Titos-García, Julio Santoyo-Santoyo, General, Digestive and Transplantation Surgery Department, University Regional Hospital, 29010 Málaga, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Titos-García
authors.affiliation: José Manuel Aranda-Narváez, Antonio Jesús González-Sánchez, María Custodia Montiel-Casado, Alberto Titos-García, Julio Santoyo-Santoyo, General, Digestive and Transplantation Surgery Department, University Regional Hospital, 29010 Málaga, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Santoyo-Santoyo
keywords: Acute pancreatitis; Minimal access retroperitoneal pancreatic necrosectomy; Necrotizing pancreatitis; Open necrosectomy; Surgery; Video-assisted retroperitoneal debridement