title: Mass spectrometry-based proteomics in Chest Medicine, Gerontology, and Nephrology: subgroups omics for personalized medicine.
abstract: Mass spectrometry (MS) is currently the most promising tool for studying proteomics to investigate largescale proteins in a specific proteome. Emerging MS-based proteomics is widely applied to decipher complex proteome for discovering potential biomarkers. Given its growing usage in clinical medicine for biomarker discovery to predict, diagnose and confer prognosis, MS-based proteomics can benefit study of personalized medicine. In this review we introduce some fundamental MS theory and MS-based quantitative proteomic approaches as well as several representative clinical MS-based proteomics issues in Chest Medicine, Gerontology, and Nephrology.
authors.affiliation: Institute of Clinical Medical Science, China Medical University College of Medicine, 404 Taichung, Taiwan ; Department of Internal Medicine, China Medical University Hospital, 404 Taichung, Taiwan ; Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan.
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Institute of Clinical Medical Science, China Medical University College of Medicine, 404 Taichung, Taiwan ; Department of Internal Medicine, China Medical University Hospital, 404 Taichung, Taiwan ; Division of Pulmonary and Critical Care Medicine, China Medical University Hospital and China Medical University, 404 Taichung, Taiwan.
authors.forename: Wu-Huei
authors.initials: WH
authors.lastname: Hsu
authors.affiliation: Institute of Clinical Medical Science, China Medical University College of Medicine, 404 Taichung, Taiwan ; Department of Family Medicine, China Medical University Hospital, 404 Taichung, Taiwan ; School of Medicine, College of Medicine China Medical University, No. 91, Hsueh Shih Road, 404 Taichung, Taiwan.
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Road, 402 Taichung, Taiwan ; Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, 404 Taichung, Taiwan.
authors.forename: Chao-Jung
authors.initials: CJ
authors.lastname: Chen
keywords: Chest Medicine;; Gerontology; Mass spectrometry;; Nephrology;; Personalized medicine;; Proteomics;