title: Cardiac energetic impairment in heart disease and the potential role of metabolic modulators: a review for clinicians.
abstract: Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.
authors.affiliation: From the Department of Cardiovascular Medicine, University of Aberdeen, Aberdeen, United Kingdom (S.S., K.S., M.F.); and Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia (J.H.).
authors.forename: Satnam
authors.initials: S
authors.lastname: Singh
authors.affiliation: From the Department of Cardiovascular Medicine, University of Aberdeen, Aberdeen, United Kingdom (S.S., K.S., M.F.); and Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia (J.H.).
authors.forename: Konstantin
authors.initials: K
authors.lastname: Schwarz
authors.affiliation: From the Department of Cardiovascular Medicine, University of Aberdeen, Aberdeen, United Kingdom (S.S., K.S., M.F.); and Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia (J.H.).
authors.forename: John
authors.initials: J
authors.lastname: Horowitz
authors.affiliation: From the Department of Cardiovascular Medicine, University of Aberdeen, Aberdeen, United Kingdom (S.S., K.S., M.F.); and Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia (J.H.). m.p.frenneaux@abdn.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Frenneaux
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D002309:Cardiology / Q000379:methods*; D002334:Carnitine O-Palmitoyltransferase / Q000037:antagonists & inhibitors; D004579:Electron Transport; D005227:Fatty Acids / Q000737:chemistry; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia; D007333:Insulin Resistance; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species
chemical_list: D005227:Fatty Acids; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D002334:Carnitine O-Palmitoyltransferase; D010100:Oxygen
keywords: drug therapy; energy metabolism; perhexiline; reperfusion injury