title: [A systemic review of low intensity anticoagulation therapy for Chinese population with heart valve replacement].
abstract: OBJECTIVE
  To investigate the safety and efficacy of low intensity anticogulation therapy for chinese population underwent heart valve replacemnt.
  
  
  METHODS
  From January 1999 to October 2010, the literatures concering anticoagulation therapy for chinese population with heart valve replacement were researched in following databases: CBM, CNKI, VIP, Pubmed as well as cochrane library. Screening and quality evaluation was conducted according to the inclusion and exclusion criteria. Meta-analysis of control studies and descriptive analysis of descriptive studies were conducted.
  
  
  RESULTS
  Total 61 articles were reviewed, including 4 control studies and 57 descriptive studies. Both Meta analysis and descriptive analysis results showed also that the rates of total anticoagulation-related complications as well as bleeding events were significantly decreased in patients receiving low intensity anticoagulation therapy in compared with classical intensity strategy (RR = -0.06, 95%CI: -0.08--0.03, P < 0.001;RR = -0.06 , 95%CI:-0.08-0.04, P < 0.001), while no significant differeces were noted as for risk of thrmoboembolic events among two different intensity groups (RR = 0.01, 95%CI:-0.01-0.03, P > 0.05).
  
  
  CONCLUSIONS
  Low intensity anticoagulation therapy (INR ≤ 2.5) could effectively miminze the anticoagulation-related hemorrhage and mortality rates and while without increasing the rates of thrmoboembolic event. This therapy was safe, effective and suitable for the coagulation characteristics of Chinese population.
authors.affiliation: Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Email: syk@mcwcums.com.
authors.forename: Yingkang
authors.initials: Y
authors.lastname: Shi
authors.forename: Bo
authors.initials: B
authors.lastname: Fu
authors.forename: Xiao
authors.initials: X
authors.lastname: Teng
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.forename: Bengui
authors.initials: B
authors.lastname: Zhang
mesh_terms: D006801:Humans; D000925:Anticoagulants; D001777:Blood Coagulation; D006348:Cardiac Surgical Procedures; D006351:Heart Valves; D006470:Hemorrhage
chemical_list: D000925:Anticoagulants