title: Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages.
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea [3] Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Yun
authors.initials: HY
authors.lastname: Kim
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Hyunjin V
authors.initials: HV
authors.lastname: Kim
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.
authors.forename: Jin H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Bo Ram
authors.initials: BR
authors.lastname: Kang
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Soo Min
authors.initials: SM
authors.lastname: Cho
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Sejin
authors.initials: S
authors.lastname: Lee
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Ji Yoon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Department of Applied Chemistry, Dongduk Women's University, Seoul, Republic of Korea.
authors.forename: Joo Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
authors.forename: Yakdol
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
authors.forename: Jiwan
authors.initials: J
authors.lastname: Woo
authors.affiliation: 1] Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea [2] Biological Chemistry Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
authors.forename: YoungSoo
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D060766:Drinking Water; D006801:Humans; D007124:Immunoenzyme Techniques; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control*; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000502:physiology*; D013654:Taurine / Q000008:administration & dosage*
chemical_list: C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D060766:Drinking Water; C508853:PSEN1 protein, human; D053764:Presenilin-1; D013654:Taurine