title: The effect of intraurethral dexpanthenol on healing and fibrosis in rats with experimentally induced urethral trauma.
abstract: OBJECTIVE
  To determine the efficacy of dexpanthenol applied early after urethral trauma for preventing inflammation and spongiofibrosis.
  
  
  METHODS
  Twenty-seven rats were randomized and divided into 3 groups, with 9 rats in each group. The urethras of all rats were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14 days, group I was given 0.9% saline twice a day (control group), group II was given dexpanthenol 500 mg/kg ampules once a day and 0.9% saline once a day, and group III was given dexpanthenol 500 mg/kg ampules twice a day intraurethrally using a 22 ga catheter sheath. On day 15, the penises of the rats were degloved to perform penectomy.
  
  
  RESULTS
  The mean fibrosis scores were 2.4, 2.2, and 1.4, and mean inflammation scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for inflammation (P = .011); however, the difference for fibrosis was not significant (P = .331). The differences between groups I and III were statistically significantly different both for inflammation and fibrosis (P = .004 and P = .003, respectively). Groups II and III were not different significantly for inflammation (P = .638); however, there was less fibrosis in group III, in which high-dose dexpanthenol was administered.
  
  
  CONCLUSIONS
  We showed that dexpanthenol applied early after urethral trauma significantly decreased inflammation and spongiofibrosis. We hope that our study will help to decrease strictures after urethral trauma and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yardimci
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey. Electronic address: tolgakarakan@yahoo.com.
authors.forename: Tolga
authors.initials: T
authors.lastname: Karakan
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey; Department of Urology, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Berkan
authors.initials: B
authors.lastname: Resorlu
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozcan
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Aydın
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Demirbas
authors.affiliation: Department of Pathology, Ankara Research and Training Hospital, Ankara, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Unverdi
authors.affiliation: Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eroglu
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000517:prevention & control; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar; D014521:Urethra / Q000293:injuries* / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010205:Pantothenic Acid; C007288:dexpanthenol