title: Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration.
abstract: In this issue, Sorbara et al. (2014) demonstrate that axonal transport impairment is an early feature of neurodegeneration in multiple sclerosis models. This transport deficit is reversible by anti-inflammatory intervention but, if untreated, can contribute to late-stage axonal dystrophy.
authors.affiliation: Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
authors.forename: Calliope A
authors.initials: CA
authors.lastname: Dendrou
authors.affiliation: Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Clinical Institute, Aarhus University Hospital, Skejby Sygehus, DK-8000 Aarhus, Denmark. Electronic address: lars.fugger@imm.ox.ac.uk.
authors.forename: Lars
authors.initials: L
authors.lastname: Fugger
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000502:physiology*; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology*