title: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.
abstract: Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Rd, Rochester, New York 14627, USA. fasan@chem.rochester.edu.
authors.forename: Gopeekrishnan
authors.initials: G
authors.lastname: Sreenilayam
authors.forename: Rudi
authors.initials: R
authors.lastname: Fasan
mesh_terms: D000588:Amines / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D009211:Myoglobin / Q000737:chemistry*
chemical_list: D000588:Amines; D002243:Carbolines; D004952:Esters; D009211:Myoglobin; C100106:dicarbine