title: How I use fibrinogen replacement therapy in acquired bleeding.
abstract: Fibrinogen is a critical protein for hemostasis and clot formation. However, transfusion guidelines have variable recommendations for maintaining fibrinogen levels in bleeding patients. An increasing number of studies support the practice of fibrinogen replacement therapy for acquired coagulopathies, and additional studies are underway. Fibrinogen therapy can be administered with cryoprecipitate or fibrinogen concentrates, and clinical practice varies according to their availability and licensing status. Fibrinogen concentrate therapy has been studied in animal models and clinical trials and supports the critical role of fibrinogen repletion in bleeding patients. Point-of-care testing will have an important role in guiding fibrinogen replacement for hemostatic therapy in clinical settings such as cardiovascular surgery, postpartum hemorrhage, and trauma. Fibrinogen therapy is an important component of a multimodal strategy for the treatment of coagulopathic bleeding.
authors.affiliation: Department of Anesthesiology and Department of Surgery, Duke University School of Medicine, Durham, NC; and.
authors.forename: Jerrold H
authors.identifier: http://orcid.org/0000-0003-3766-4962
authors.initials: JH
authors.lastname: Levy
authors.affiliation: Department of Pathology and Department of Medicine, Stanford University, Stanford, CA.
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Goodnough
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D005340:Fibrinogen / Q000032:analysis / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D011379:Prognosis
chemical_list: D005340:Fibrinogen