title: MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy.
abstract: OBJECTIVE
  To search subclinical platelet activation via detecting three important platelet activation parameters; mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in diabetic retinopathy (DR) in comparison with those in healthy adults as controls.
  
  
  METHODS
  This prospective study included 140 patients who were followed-up at the Ankara Ulucanlar Eye Education and Research Hospital, and 40 normal subjects. All patients and control subjects underwent complete ophthalmologic evaluation. Of patients with type 2 diabetes, 43 cases with diabetes mellitus (DM) have no DR (Group 1), 45 cases with DM have nonproliferative DR (NPDR) (Group 2), and 52 cases with DM have proliferative DR (PDR) (Group 3). In addition, 40 age- and sex-matched healthy controls (Group 4) were included into the study. MPV, PDW, and PCT were measured in the studied groups.
  
  
  RESULTS
  The MPV levels were significantly altered in Group 1, Group 2, and Group 3 patients when compared with those in the controls (P<0.05), whereas PDW and PCT levels were not significantly changed among groups (P>0.05).
  
  
  CONCLUSIONS
  The data provided a significant association between MPV levels and DM. Diabetic patients have increased MPV values compared with healthy subjects, but MPV levels were not altered together with the DR stage. Diabetic and DR patients have no different PDW and PCT values compared with healthy subjects. MPV may be a clue for the reflection of subclinical platelet activation in DM regardless of the DR stage.
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Citirik
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Beyazyildiz
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Simsek
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Beyazyildiz
authors.affiliation: Department of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: I C
authors.initials: IC
authors.lastname: Haznedaroglu
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count; D011446:Prospective Studies