title: A case of delayed oxaliplatin-induced pseudo-obstruction: an atypical presentation of oxaliplatin neurotoxicity.
abstract: Chemotherapy-induced neurotoxicity is a serious complication of cancer treatment. Oxaliplatin, a third-generation platinum drug, has become one of the first-line therapies used in the treatment of metastatic colorectal cancer. Peripheral neuropathy is a common complication of platinum-based chemotherapy. Most commonly a sensory neuropathy occurs with cold-triggered symptoms in the acute phase and numbness and painful paresthesias as a late presentation. Autonomic neurotoxicity and late presentation, months after cessation of the therapy, has rarely been described. We report a patient who clinically presented with a pseudo-obstruction months after treatment with oxaliplatin for metastatic colorectal cancer. Intestinal adhesions and relapsing malignancy were carefully excluded. By exclusion the pseudo-obstruction was attributed to a toxic oxaliplatin-induced autonomic neuropathy which slowly improved during months of follow-up.
authors.forename: M
authors.initials: M
authors.lastname: Vandamme
authors.forename: W
authors.initials: W
authors.lastname: Pauwels
authors.forename: J De
authors.initials: JD
authors.lastname: Bleecker
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003082:Colectomy / Q000379:methods; D003112:Colonic Pseudo-Obstruction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D020258:Neurotoxicity Syndromes / Q000150:complications / Q000209:etiology; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077150:Oxaliplatin; D010288:Parenteral Nutrition / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000150:complications; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil
keywords: Autonomic neuropathy,; Metastatic colorectal cancer,; Neurotoxicity,; Oxaliplatin,; Pseudo-obstruction