title: Increased sister chromatid exchange in peripheral blood lymphocytes from humans exposed to pesticide: evidence based on a meta-analysis.
abstract: BACKGROUND
  Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure.
  
  
  OBJECTIVE
  To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide.
  
  
  METHODS
  Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study.
  
  
  RESULTS
  The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses.
  
  
  CONCLUSIONS
  Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic effects for pesticide-exposed populations.
authors.affiliation: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China E-mail : wangyd76@163.com.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Si-Yu
authors.initials: SY
authors.lastname: Yang
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Wang
mesh_terms: D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D010575:Pesticides