title: Biomarkers in IgA nephropathy.
abstract: IgA nephropathy is the most common primary glomerulonephritis and presents with gross hematuria and upper respiratory infection, with slow progression to end-stage renal disease in up to 50% of affected patients. Kidney biopsies are the gold standard method of diagnosis and frequently are not performed as the majority of individuals are asymptomatic. Thus, there is a need to discover and validate prognostic and predictive biomarkers that can be noninvasively obtained and are specific to this disease. Here we discuss the current state of research in this area and examine validated and clinically promising biofluid and tissue biomarkers of IgA nephropathy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Genome & Biomedical Sciences Building, Room 6312, University of California, Davis, CA 95616, USA.
authors.forename: Vicki J
authors.initials: VJ
authors.lastname: Hwang
authors.forename: Arzu
authors.initials: A
authors.lastname: Ulu
authors.forename: Justin
authors.initials: J
authors.lastname: van Hoorebeke
authors.forename: Robert H
authors.initials: RH
authors.lastname: Weiss
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D011506:Proteins
keywords: IgA nephropathy; biofluid; glomerulonephritis; glycomics; predictive biomarker; prognostic biomarker; tissue