title: [Relationship between serum histamine levels and ST-segment resolution in patients with acute myocardial infarction treated with primary percutaneous coronary intervention].
abstract: OBJECTIVE
  To investigate the dynamic changes in serum histamine levels and their association with ST-segment resolution in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  A total of 84 consecutive STEMI patients who received primary PCI were enrolled in this study. The dynamic changes in serum histamine levels were observed from before PCI to 1 week after PCI. Factors associated with ST-segment resolution were identified by multivariate regression analysis.
  
  
  RESULTS
  The serum histamine levels of STEMI patients decreased during the first week after PCI. Multivariate regression analysis showed that the factors associated with ST-segment resolution 2 h after PCI were: the histamine level 2 h after PCI (r=-0.361, P=0.001), pain to balloon time, infarct related artery, and thrombolysis in myocardial infarction (TIMI) flow grade after PCI.
  
  
  CONCLUSIONS
  The higher histamine level 2 h after PCI was independently associated with poor myocardial reperfusion in STEMI patients.
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: D
authors.initials: D
authors.lastname: Mu
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: M
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: C
authors.initials: C
authors.lastname: Ren
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Guo
mesh_terms: D006632:Histamine / Q000097:blood*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000628:therapy*; D015425:Myocardial Reperfusion; D062645:Percutaneous Coronary Intervention; D016896:Treatment Outcome
chemical_list: D006632:Histamine