title: The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma.
abstract: The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is not defined. The aim of this meta-analysis was to evaluate the prognostic value of cyclin D1 in patients with head and neck cancer. A search thorough Ovid MEDLINE was performed to enroll all eligible articles. Twenty-two studies comprising a total of 1,929 patients with different head and neck cancers were included. Cyclin D1 overexpression was significantly associated with lymph node metastasis [OR 2.25; 95 % confidence interval (CI) 1.76-2.87] and worse disease-free survival (OR 3.06; 95 % CI 2.42-3.87]. Subgroup analysis revealed that cyclin D1 overexpression correlated significantly with nodal metastasis for laryngeal cancer (OR 2.26; 95 % CI 1.61-3.16) and was a significant poor predictor for nasopharyngeal cancer (OR 4.44; 95 % CI 1.89-10.42). Our meta-analysis suggests that cyclin D1 overexpression could represent an important prognostic indicator for patients with head and neck cancer.
authors.affiliation: Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy. giox83@hotmail.com.
authors.forename: Federico M
authors.initials: FM
authors.lastname: Gioacchini
authors.affiliation: Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Alicandri-Ciufelli
authors.affiliation: Department of Diagnostic Medicine, Clinical and Public Health University Hospital of Modena, Modena, Italy.
authors.forename: Shaniko
authors.initials: S
authors.lastname: Kaleci
authors.affiliation: Department of Otorhinolaryngology ''G. Ferreri'', ''La Sapienza'' University, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magliulo
authors.affiliation: Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy.
authors.forename: Livio
authors.initials: L
authors.lastname: Presutti
authors.affiliation: Otorhinolaryngology Department, Marche Polytechnic University, Ancona, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Re
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D019938:Cyclin D1 / Q000096:biosynthesis / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D014943:Global Health; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D006801:Humans; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate / Q000639:trends
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers; D019938:Cyclin D1
keywords: Biomarkers; Cyclin D1; Head and neck cancer; Prognosis; Survival