title: In vitro activity of fosfomycin tromethamine against extended spectrum beta-lactamase producing urinary tract bacteria.
abstract: OBJECTIVE
  To determine the in vitro activity of Fosfomycin tromethamine against extended spectrum beta-lactamase producing uropathogens.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi, from October 2011 to October 2012.
  
  
  METHODS
  A total of 381 culture positive ESBL producing isolates from 2400 urine samples submitted over a period of one year were included in this study. Identification of isolates was done by standard biochemical profile of the organisms. The antimicrobial susceptibility of culture positive isolates was performed by disk diffusion method as recommended by Clinical Laboratory Standard Institute guidelines (CLSI).
  
  
  RESULTS
  The antimicrobial activity of Fosfomycin to various isolates revealed that 93% of E. coli, 64% Klebsiella spp. 50% Proteus spp. 75% Enterobacter cloacae, 100% Citrobacter freundii, 100% Burkholderia spp. 100% Serratia spp. and 50% Stenotrophomonas maltophilia were susceptible to this chemical compound.
  
  
  CONCLUSIONS
  Fosfomycin showed excellent effectiveness to most of the common ESBL producing bacteria such as E. coli, Klebsiella and Proteus spp.
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Inam Ullah
authors.initials: IU
authors.lastname: Khan
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Irfan Ali
authors.initials: IA
authors.lastname: Mirza
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Aamer
authors.initials: A
authors.lastname: Ikram
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Shamshad
authors.initials: S
authors.lastname: Ali
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Aamir
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Tahir
authors.initials: T
authors.lastname: Ghafoor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005578:Fosfomycin / Q000494:pharmacology* / Q000627:therapeutic use*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014551:Urinary Tract / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D056689:Uropathogenic Escherichia coli / Q000187:drug effects; D055815:Young Adult; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D001618:beta-Lactamases