title: Hepatitis E in developed countries: current status and future perspectives.
abstract: Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genotypes 3 (HEV3) and 4 (HEV4). The clinical phenotype of hepatitis E continues to emerge, and recent data show that HEV is associated with a range of neurological syndromes including Guillain-Barré syndrome and neuralgic amytrophy.
authors.affiliation: Cornwall Gastrointestinal Unit, Royal Cornwall Hospital & European Centre for the Environment & Human Health, University of Exeter Medical School, Truro TR1 3LJ, UK.
authors.forename: Harry R
authors.initials: HR
authors.lastname: Dalton
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D019049:Developed Countries; D003906:Developing Countries; D005260:Female; D005838:Genotype; D016751:Hepatitis E / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D016752:Hepatitis E virus / Q000235:genetics; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology; D013552:Swine; D015047:Zoonoses
keywords: chronic infection; cirrhosis; hepatitis; hepatitis E; pigs; zoonosis