title: Effect of intraperitoneal curcumin instillation on postoperative peritoneal adhesions.
abstract: OBJECTIVE
  The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model.
  
  
  METHODS
  Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined.
  
  
  RESULTS
  There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05).
  
  
  CONCLUSIONS
  These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.
authors.affiliation: Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakır,Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Türkoğlu
authors.forename: Mesut
authors.initials: M
authors.lastname: Gül
authors.forename: Hatice Kurt
authors.initials: HK
authors.lastname: Yuksel
authors.forename: Ulas
authors.initials: U
authors.lastname: Alabalik
authors.forename: Burak Veli
authors.initials: BV
authors.lastname: Ülger
authors.forename: Omer
authors.initials: O
authors.lastname: Uslukaya
authors.forename: Yahya
authors.initials: Y
authors.lastname: Avci
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D002432:Cecum / Q000187:drug effects* / Q000473:pathology; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D006909:Hydroxyproline / Q000032:analysis; D007263:Infusions, Parenteral; D008297:Male; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology; D011183:Postoperative Complications / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin; D006909:Hydroxyproline