title: [Research on bitter components from Coptis chinensis based on electronic tongue].
abstract: Isolated alkaloids from Coptis chinensis Franch. The compounds were identified as berberine, columbamine, groenlandicine, jatrorrhizine, magnoflorine, corydaldine and ferulic acid methylester. Then measured their bitter degree based on the electronic tongue and evaluated the antibacterial. The results based on the Electronic Tongue showed that berberine, columbamine, groenlandicine and jatrorrhizine have higher bitter degree than magnoflorine and corydaldine. And they also appeared better antibacterial activity on E. coli and S. aureus. The correlation coefficients between bitter degree and the two bacteria antibacterial activity were 0.983 and 0.911. So there was close relationship between the bitter degree and antibacterial activity of bitter components. Thus, it is confirmed further that bitter components are the material foundation of medicinal effectiveness of bitter herbs.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Liang
authors.forename: Fei
authors.initials: F
authors.lastname: Wu
authors.forename: You-Jie
authors.initials: YJ
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
mesh_terms: D001060:Aporphines / Q000032:analysis; D001599:Berberine / Q000031:analogs & derivatives / Q000032:analysis; D001600:Berberine Alkaloids / Q000032:analysis; D035843:Biomedical Research / Q000295:instrumentation / Q000379:methods; D039323:Coptis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D004581:Electronics / Q000295:instrumentation / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015203:Reproducibility of Results; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013649:Taste
chemical_list: D001060:Aporphines; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; C055785:jatrorrhizine; D001599:Berberine; C055786:columbamine; C001670:magnoflorine