title: [Sensivity of some enzymes in Guérin tumours after the administration of Nystatin MC].
abstract: In the animals with a 24 hours and 15 days transplant of Guérin lymphotropic epithelioma Nystatin MC in a dose of 800 mg/K body weight/day and 1 800 mg/K body weight/day every 3 and 6 hours daily for 8 days was injected subcutaneously. The dosing of the activity of gluthamin-synthetase, MDH and catalase in tumours of 8, 23, and 38 days showed that Nystatin MC disturbed the activity of the enzymes from mythocondries and cytoplasm especially in the 8 and 23 days tumours, influencing the glycolitic process. The gluthamin-synthesis was inhibited during the entire tumoral activity period, reaching after treatment almost normal values. Cytoplasmic MDH was influenced by the treatment in relation with the age of the tumour and the used dose. I
authors.forename: L
authors.initials: L
authors.lastname: Enescu
authors.forename: L
authors.initials: L
authors.lastname: Bazgan
authors.forename: M
authors.initials: M
authors.lastname: Pavel
authors.forename: L
authors.initials: L
authors.lastname: Jerca
authors.forename: N
authors.initials: N
authors.lastname: Gheorghiţă
authors.forename: A
authors.initials: A
authors.lastname: Iacobovici
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D050538:Malate Dehydrogenase (NADP+) / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000201:enzymology; D009761:Nystatin / Q000008:administration & dosage; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000201:enzymology*
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D014408:Biomarkers, Tumor; D009761:Nystatin; D050538:Malate Dehydrogenase (NADP+); D002374:Catalase; D005974:Glutamate-Ammonia Ligase