title: Effect and tolerability of blonanserin in severe delusion with various types of dementia.
abstract: Low-dose blonanserin was effective for treating severe delusions in six patients with various types of dementia, and it was also well tolerated. Delusion and hallucination scores, as measured by the Neuropsychiatric Inventory, improved, and extrapyramidal symptom scores, as measured by the Drug-Induced Extrapyramidal Symptoms Scale, were unchanged. Blonanserin has strong dopamine D2receptor-, 5-hydroxytryptamine 2A receptor-, and dopamine D3receptor-blocking activities and weak 5-hydroxytryptamine-2C, α1-, histamine H1-, and muscarinic M1-blocking activities. Its unique characteristics may make it suitable for treating severe delusions and hallucination in patients with dementia.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Takaki
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Honda
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Terada
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Uchitomi
keywords: D3 receptor; blonanserin; delusion; dementia; hallucination