title: Redox cycling of copper-amyloid β 1-16 peptide complexes is highly dependent on the coordination mode.
abstract: Copper (Cu)-amyloid β (Aβ) interactions play a role in the etiology of Alzheimer's disease. This work presents a spectroscopic and electrochemical study of two physiologically relevant Aβ-Cu(II) complexes, as a function of pH and relative Cu-Aβ(1-16) concentrations. Our results reveal that these coordination modes display distinct redox behaviors and provide experimental evidence for the existence of an intermediate Cu(I) species. A mechanism for the redox cycling of these complexes is proposed, providing further insight into the redox relevance of Aβ-Cu interactions.
authors.affiliation: Departamento de Química, Centro de Investigación y de Estudios Avanzados (Cinvestav) , Avenida Instituto Politecnico Nacional 2508, San Pedro Zacatenco, 07360 Ciudad de México, D.F., Mexico.
authors.forename: Lidia G
authors.initials: LG
authors.lastname: Trujano-Ortiz
authors.forename: Felipe J
authors.initials: FJ
authors.lastname: González
authors.forename: Liliana
authors.initials: L
authors.lastname: Quintanar
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000737:chemistry*; D012996:Solutions; D013816:Thermodynamics
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D010446:Peptide Fragments; D012996:Solutions; C433241:amyloid beta-protein (1-16); D003300:Copper