title: [DNA methylation in obesity].
abstract: The number of overweight and obese people is increasing at an alarming rate, especially in the developed and developing countries. Obesity is a major risk factor for diabetes, cardiovascular disease, and cancer, and in consequence for premature death. The development of obesity results from the interplay of both genetic and environmental factors, which include sedentary life style and abnormal eating habits. In the past few years a number of events accompanying obesity, affecting expression of genes which are not directly connected with the DNA base sequence (e.g. epigenetic changes), have been described. Epigenetic processes include DNA methylation, histone modifications such as acetylation, methylation, phosphorylation, ubiquitination, and sumoylation, as well as non-coding micro-RNA (miRNA) synthesis. In this review, the known changes in the profile of DNA methylation as a factor affecting obesity and its complications are described.
authors.affiliation: Ośrodek Badań Genetycznych i Nutrigenomiki, Małopolskie Centrum Biotechnologii, Uniwersytet Jagielloński.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pokrywka
authors.affiliation: Katedra i Klinika Chorób Metabolicznych Collegium Medicum Uniwersytetu Jagiellońskiego.
authors.forename: Beata
authors.initials: B
authors.lastname: Kieć-Wilk
authors.affiliation: Katedra Biochemii Klinicznej Collegium Medicum Uniwersytetu Jagiellońskiego.
authors.forename: Anna
authors.initials: A
authors.lastname: Polus
authors.affiliation: Ośrodek Badań Genetycznych i Nutrigenomiki, Małopolskie Centrum Biotechnologii, Uniwersytet Jagielloński; Katedra Biochemii Klinicznej Collegium Medicum Uniwersytetu Jagiellońskiego.
authors.forename: Iwona
authors.initials: I
authors.lastname: Wybrańska
mesh_terms: D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000235:genetics*; D012307:Risk Factors