title: Treatment outcomes of the patients with early glottic cancer treated with initial radiotherapy and salvaged by conservative surgery.
abstract: OBJECTIVE
  This retrospective study analyzed the oncological and treatment outcomes of the patients with T1-T2N0 glottic cancer, who were treated with radiotherapy as initial treatment and salvaged by conservative surgery for radiation failure.
  
  
  METHODS
  Between May 1999 and December 2010, 115 patients with glottic laryngeal cancer were treated at Kobe University Hospital. At presentation, 54 patients had stage T1a disease, 26 had stage T1b disease and 35 had stage T2 disease. Seventy-nine patients were treated with conventional radiotherapy and 36 patients were treated with hyperfractionated radiotherapy as initial treatment.
  
  
  RESULTS
  Median duration of follow-up was 61 months. Five-year local control rates of radiotherapy were 92% in T1a, 83% in T1b and 86% in T2. Of 12 patients who developed local recurrence, larynx was successfully preserved in 3 patients by laryngomicrosurgery, 7 patients by vertical partial laryngectomy and one patient by subtotal laryngectomy. Ultimate 5-year laryngeal preservation rate and local control rate of all cases were 99 and 100%, respectively.
  
  
  CONCLUSIONS
  Present results suggest that initial treatment with radiotherapy salvaged by organ preservation surgery is an effective strategy for laryngeal preservation in the treatment of T1-T2N0 glottic laryngeal cancer.
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Aya
authors.initials: A
authors.lastname: Harada
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe rsasaki@med.kobe-u.ac.jp.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sasaki
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Miyawaki
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishimura
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ejima
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kitajima
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Saito
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Otsuki
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nibu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery; D055088:Early Detection of Cancer; D005260:Female; D005931:Glottis; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery; D059351:Organ Sparing Treatments / Q000379:methods / Q000706:statistics & numerical data; D011855:Radiodermatitis / Q000209:etiology; D011879:Radiotherapy Dosage; D012086:Reoperation / Q000379:methods; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods; D013280:Stomatitis / Q000209:etiology; D016896:Treatment Outcome
keywords: glottic cancer; organ preservation; radiotherapy; salvage therapy