title: Prognostic role of thyroid transcription factor-1 (TTF-1) in advanced and inoperable adenocarcinoma subtype of lung cancer among Thai patients.
abstract: OBJECTIVE
  To determine the role of thyroid transcription factor-1 (TTF-1) as a prognostic factor in advanced adenocarcinoma of non-small cell lung cancer.
  
  
  METHODS
  Retrospective cohort study among lung cancer patients with inoperable or metastases, adenocarcinoma type whose tumors were already tested for TTF-1 in Rajavithi Hospital from December 2003 to November 2011. The correlation of TTF-1 to survival period and the treatment outcomes were defined.
  
  
  RESULTS
  Of 67 patients, 48 TTF-1 positive cases and 19 TTF-1 negative cases were included in the analysis. Median overall survival for all population was 263 days (111-415 days). No significant difference was found between TTF-1 positive and negative tumors (251 and 369 days, p-value = 0.8). The systemic treatment with chemotherapy was the only effective prognostic factor for survival of this study.
  
  
  CONCLUSIONS
  The prognostic factor of TTF-1 positive and negative in advanced adenocarcinoma subtype of NSCLC was not different in median overall survival.
authors.forename: Jedzada
authors.initials: J
authors.lastname: Maneechawakajorn
authors.forename: Duangnapa
authors.initials: D
authors.lastname: Benjawongsathien
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000453:epidemiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis* / Q000737:chemistry; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013785:Thailand / Q000453:epidemiology; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis* / Q000737:chemistry
chemical_list: C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors