title: Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.
abstract: Accumulation of glutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs. In the current issue of Neuron, Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also provide the conductances necessary to maintain the appropriate voltage and pH inside these vesicles.
authors.affiliation: Department of Anesthesiology, Department of Physiology and Biophysics, Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: ala2022@med.cornell.edu.
authors.forename: Alessio
authors.initials: A
authors.lastname: Accardi
mesh_terms: D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism*; D050598:Vesicular Glutamate Transport Protein 1 / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002712:Chlorides; D018377:Neurotransmitter Agents; D050598:Vesicular Glutamate Transport Protein 1; D018698:Glutamic Acid; D011188:Potassium