title: Different resting-state functional connectivity alterations in smokers and nonsmokers with Internet gaming addiction.
abstract: This study investigated changes in resting-state functional connectivity (rsFC) of posterior cingulate cortex (PCC) in smokers and nonsmokers with Internet gaming addiction (IGA). Twenty-nine smokers with IGA, 22 nonsmokers with IGA, and 30 healthy controls (HC group) underwent a resting-state fMRI scan. PCC connectivity was determined in all subjects by investigating synchronized low-frequency fMRI signal fluctuations using a temporal correlation method. Compared with the nonsmokers with IGA, the smokers with IGA exhibited decreased rsFC with PCC in the right rectus gyrus. Left middle frontal gyrus exhibited increased rsFC. The PCC connectivity with the right rectus gyrus was found to be negatively correlated with the CIAS scores in the smokers with IGA before correction. Our results suggested that smokers with IGA had functional changes in brain areas related to motivation and executive function compared with the nonsmokers with IGA.
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Weina
authors.initials: W
authors.lastname: Ding
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhuang
authors.affiliation: Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Child & Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Yasong
authors.initials: Y
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000328:Adult; D016739:Behavior, Addictive / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D006801:Humans; D020407:Internet; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012907:Smoking / Q000503:physiopathology*; D018910:Video Games / Q000009:adverse effects*