title: [Comparison of the cardiovascular predictive value of MDRD and CKD-EPI in estimating chronic kidney disease].
abstract: OBJECTIVE
  To assess predictive value of the cardiovascular prognosis by comparing the two most used formulas for the estimation of glomerular filtration rate in hypertensive patients.
  
  
  METHODS
  A retrospective cohort study was designed that included 405 patients diagnosed with essential hypertension. The patients were referred from Primary Care to the Hypertension and Vascular Risk Unit between January 1, 1998 and August 31, 1999. Blood pressure measurements, blood and urine analysis, and echocardiography were simultaneously performed. They were followed up for 12.5 years (mean [± IQR]: 10.61 [± 3.11] years) and 174 events were recorded.
  
  
  RESULTS
  The study included 405 patients (53.8% women), with a mean age of 55.5 years. The estimated glomerular filtration rate according to the MDRD and CKD-EPI equations was 73.9±2.6 mL/min/1.73m(2) and 76.9±2.2 mL/min/1.73m(2), respectively. The prevalence of chronic kidney disease was 31.6% and 23.9%, respectively. Using the CKD-EPI equation led to the re-classification of 22.9% of patients. The incidence rate ratio (IRR [95%CI] for chronic kidney disease identified by the MDRD equation was 2.4 [1.8-3.3], and for the CKD-EPI calculation it was 2.5 [1.8 to 3.3]).
  
  
  CONCLUSIONS
  Both equations estimate similar magnitudes of renal function, although the CKD-EPI equation has less false positives, and both have similar prognostic values in patients at high cardiovascular risk as well those at low risk.
authors.affiliation: Medicina Familiar y Comunitaria, Centro de Salud de Porto do Son, Porto do Son, A Coruña, España. Electronic address: scinzas@semergen.es.
authors.forename: S
authors.initials: S
authors.lastname: Cinza-Sanjurjo
authors.affiliation: Unidad de HTA y Riesgo Cardiovascular, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: C
authors.initials: C
authors.lastname: Calvo-Gómez
authors.affiliation: Unidad de HTA y Riesgo Cardiovascular, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: A
authors.initials: A
authors.lastname: Hermida-Ameijeiras
authors.affiliation: Unidad de HTA y Riesgo Cardiovascular, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: J E
authors.initials: JE
authors.lastname: López-Paz
authors.affiliation: Servicio de Cardiología, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: J R
authors.initials: JR
authors.lastname: González-Juanatey
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis*; D015331:Cohort Studies; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors
keywords: CKD-EPI; Cardiovascular prognosis; Chronic kidney disease; Enfermedad renal crónica; MDRD; Pronóstico cardiovascular