title: [Management of acute complications in sickle cell disease ].
abstract: Acute complications in sickle cell disease are a major and life-long cause for hospital referral. The most frequent events are painful acute vaso-occlusive crisis involving the limbs and back, and acute chest syndrome. Acute vaso-occlusive crisis is a therapeutic emergency because of the very high level of pain. Acute chest syndrome may be potentially fatal and must be adequately searched for and treated. Sickle cell patients are susceptible to pneumococcal infections notably, but any infection may favour vaso-occlusive crisis. Triggers of sickle cell vase occlusion must be tracked and corrected, if possible. Moderate crisis can be managed at home, but referral is necessary as soon as opiates are needed and/or if acute chest syndrome is suspected. Additional treatments besides opiates include co analgesics, oxygen, hydration, physiotherapy. Blood transfusion may be required but is not systematic. Acute spleen sequestration occurs in young children and requires immediate hospital referral for transfusion.
authors.forename: Justine
authors.initials: J
authors.lastname: Gellen-Dautremer
authors.forename: Valentine
authors.initials: V
authors.lastname: Brousse
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Arlet
mesh_terms: D000208:Acute Disease; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D006801:Humans; D007223:Infant; D014652:Vascular Diseases / Q000209:etiology / Q000628:therapy