title: IgA nephropathy in Czech patients--are we able reliably predict the outcome?
abstract: OBJECTIVE
  The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients.
  
  
  METHODS
  Cox proportional hazards regression model was used to evaluate the effects of different variables on renal survival during a median follow up of six years. McNemar´s test was used to analyse the progression of renal function according to Bartosik´s formula.
  
  
  RESULTS
  In our retrospective analysis of 520 Czech IgAN patients Cox proportional hazards regression model with five variables [hypertension, sex, GFR, proteinuria, age] was used. Significant regression coefficient was found for GFR, hypertension and proteinuria. Using stepwise algorithm GFR (OR = 3.09), hypertension (OR = 2.09) and proteinuria (OR = 1.97) were found as the most important factors for renal survival in our group of IgAN patients. Among patients with CKD 3 we found significantly better renal survival in patients with proteinuria < 1g/day compared to patients with higher proteinuria. We did not find the significant difference between predicted progression of renal function due to Bartosik´s formula and real progression of renal parametres assessed by GFR at the end of the follow up in our group of IgAN patients.
  
  
  CONCLUSIONS
  Our retrospective study of 520 Czech IgAN patients confirmed GFR, hypertension and proteinuria as the most important factors affecting the prognosis of IgAN patients. We validated Toronto Bartosik´s formula to predict prognosis of IgAN patients.
authors.affiliation: Department of Nephrology, General Teaching Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Dita
authors.initials: D
authors.lastname: Maixnerova
authors.forename: Michaela
authors.initials: M
authors.lastname: Neprasova
authors.forename: Jelena
authors.initials: J
authors.lastname: Skibova
authors.forename: Jana
authors.initials: J
authors.lastname: Mokrisova
authors.forename: Romana
authors.initials: R
authors.lastname: Rysava
authors.forename: Jana
authors.initials: J
authors.lastname: Reiterova
authors.forename: Eva
authors.initials: E
authors.lastname: Jancova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Merta
authors.forename: Josef
authors.initials: J
authors.lastname: Zadrazil
authors.forename: Eva
authors.initials: E
authors.lastname: Honsova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tesar
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome