title: Bilateral thalamic stimulation induces insomnia in patients treated for intractable tremor.
abstract: OBJECTIVE
  To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep.
  
  
  METHODS
  Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights.
  
  
  METHODS
  Sleep disorders unit of a university hospital.
  
  
  METHODS
  Eleven patients with bilateral stimulation of the ventral intermediate nucleus of the thalamus (VIM) for drug-resistant tremor.
  
  
  METHODS
  Sleep measures on polysomnography.
  
  
  RESULTS
  Total sleep time was reduced during night ON-stim compared to OFF- stim, as well as rapid eye movement sleep percentage while the percentage of N2 increased. Wakefulness after sleep onset time was increased.
  
  
  CONCLUSIONS
  Our results show that bilateral stimulation of the VIM nuclei reduces sleep and could be associated with insomnia.
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Physiologie Créteil, 94010, France.|Département de Physiologie, Hôpital Henri Mondor, Faculté de Médecine de Créteil, UPEC, Créteil, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Bridoux
authors.affiliation: CHU Poitiers, Service de Neurophysiologie Clinique, Pole Neurosciences, Poitiers, France.|Université de Poitiers, Faculté de Médecine et de Pharmacie, Poitiers, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Drouot
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Physiologie Créteil, 94010, France.|Département de Physiologie, Hôpital Henri Mondor, Faculté de Médecine de Créteil, UPEC, Créteil, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Sangare
authors.affiliation: Département de Physiologie, Hôpital Henri Mondor, Faculté de Médecine de Créteil, UPEC, Créteil, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Al-Ani
authors.affiliation: DIRO, Université de Montréal, succursale Centre-Ville, Montréal (Québec), Canada.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Brignol
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Statistiques, Créteil, France.
authors.forename: Anais
authors.initials: A
authors.lastname: Charles-Nelson
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Radiologie, Créteil, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Brugières
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Neurochirurgie, Unité de Neurochirurgie Fonctionnelle, Créteil, France.
authors.forename: Gaëtane
authors.initials: G
authors.lastname: Gouello
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Neurochirurgie, Unité de Neurochirurgie Fonctionnelle, Créteil, France.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hosomi
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Neurochirurgie, Unité de Neurochirurgie Fonctionnelle, Créteil, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lepetit
authors.affiliation: AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Neurochirurgie, Unité de Neurochirurgie Fonctionnelle, Créteil, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Palfi
mesh_terms: D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011897:Random Allocation; D012890:Sleep / Q000502:physiology; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000502:physiology*; D013997:Time Factors; D014202:Tremor / Q000628:therapy*; D014851:Wakefulness / Q000502:physiology
keywords: adverse event; deep brain stimulation; insomnia; sleep