title: Evaluation of Aquacel Ag for Autogenous Skin Donor Sites.
abstract: An ongoing objective of burn research is to evaluate wound dressings and develop new treatments to expedite wound healing. This was a single-center, prospective, randomized, controlled study to evaluate the effectiveness of Aquacel Ag as a dressing for autogenous skin donor sites compared with Xeroform. We hypothesized that donor sites treated with Aquacel Ag would heal faster. Patients were considered for enrollment if they required skin grafting with two donor sites >100 cm at least 2 inches apart. Dressings were observed daily starting on post-op day #2 until discharge and then weekly in the outpatient burn clinic. Assessments evaluated pain, infection, and reapplication. Photographs were taken on post-op day #2, upon "90% re-epithelialization," and at post-op day #30-45. Scar assessments and blinded photographic reviews were completed to assess cosmetic healing. Twenty-nine patients completed the study. Re-epithelialization occurred faster with Xeroform (15.2 days vs. 17.6 days). Daily pain scores were higher with Xeroform (6.72 vs. 5.68) and Aquacel Ag needed to be replaced more often (1.72 times vs. 0.10 times). Three patients developed donor site infections with Aquacel Ag. Scar scores between the donor sites were not statistically significant. The blinded photo review concluded that Xeroform had a better cosmetic outcome (24 vs. 10%). Although patients complained of more pain with Xeroform, it demonstrated shorter healing times and better cosmetic outcomes. Aquacel Ag needed to be replaced more often and represented the only three donor site infections.
authors.affiliation: From the The Nathan Speare Regional Burn Treatment Center, Crozer-Chester Medical Center, One Medical Center Boulevard, Upland, Pennsylvania.
authors.forename: Linwood R
authors.initials: LR
authors.lastname: Haith
authors.forename: Megan E
authors.initials: ME
authors.lastname: Stair-Buchmann
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Ackerman
authors.forename: Diane
authors.initials: D
authors.lastname: Herder
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Reigart
authors.forename: Marla
authors.initials: M
authors.lastname: Stoering
authors.forename: Robert E
authors.initials: RE
authors.lastname: Guilday
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Patton
authors.forename: Kerry M
authors.initials: KM
authors.lastname: Ross
mesh_terms: D000328:Adult; D002056:Burns / Q000601:surgery*; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010147:Pain Measurement; D010636:Phenols / Q000494:pharmacology*; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D016038:Skin Transplantation; D060053:Transplant Donor Site; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D010636:Phenols; D002266:Carboxymethylcellulose Sodium; C004554:2,4,6-tribromophenol