title: [Violation of the homologous chromosomes approchement as the answer to the small doses of roentgen irradiation].
abstract: Any violation of the homologous chromosome DNA repair leads to the genome instability, characteristic for hereditary syndromes and for aging cells. Using low doses of ionizing radiation (3-10 cGy) we have found any transference of the homologous centromere loci of the chromosome 1 (1q12) from the periphery to the cen- tre of the nucleus in the lymphocytes of young healthy donors. The same effect was found after any influence of RNA-polymerase inhibitor a-amanitine. Some changes in the chromatin structure during aging (70-80 years old patients) result in the difficulties in chromosome displacement, accompanied with any trouble in the appro- achement of the homologous chromosome loci as an answer to low doses of radiation.
authors.forename: A
authors.initials: A
authors.lastname: Bernadotte
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhelson
authors.forename: I M
authors.initials: IM
authors.lastname: Spivak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000528:radiation effects; D002878:Chromosomes, Human, Pair 1 / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D056426:Genetic Loci; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D059767:Recombinational DNA Repair / Q000528:radiation effects*; D014965:X-Rays