title: Expression of glucose transporters 1 and 3 in metastatic and non-metastatic lower lip squamous cell carcinoma.
abstract: This study aimed to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty LLSCCs with regional nodal metastasis and 20 LLSCCs without metastasis were selected. The distribution of staining and the percentage of GLUT-1 and GLUT-3 staining in each tumor core and at the deep invasive front were assessed. Most tumors (70%) exhibited peripheral staining for GLUT-1 in nests, sheets and islands of neoplastic cells, whereas predominantly central staining was observed for GLUT-3 (72.5%). A high percentage of GLUT-1-positive cells was observed at the deep invasive front and in the tumor core of metastatic and non-metastatic tumors (p>0.05). The percentage of GLUT-1-positive cells was much higher than that of GLUT-3-positive cells both in the deep invasive front (p<0.001) and in the tumor core (p<0.001) of LLSCCs. No significant differences in the percentage of GLUT-1- and GLUT-3-positive cells were observed according to nodal metastasis, clinical stage or histological grade of malignancy (p>0.05). In conclusion, the results of the present study suggest an important role of GLUT-1 in glucose uptake in LLSCCs, although this protein does not seem to be involved in the progression of these tumors. On the other hand, GLUT-3 expression may represent a secondary glucose uptake mechanism in LLSCCs.
authors.affiliation: Department of Oral Pathology, UFRN - Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Clarissa Favero
authors.initials: CF
authors.lastname: Demeda
authors.affiliation: Department of Oral Pathology, UFRN - Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Cyntia Helena Pereira de
authors.initials: CH
authors.lastname: Carvalho
authors.affiliation: Department of Dentistry, UFRN - Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Ana Rafaela Luz de
authors.initials: AR
authors.lastname: Aquino
authors.affiliation: Department of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil.
authors.forename: Cassiano Francisco Weege
authors.initials: CF
authors.lastname: Nonaka
authors.affiliation: Department of Oral Pathology, UFRN - Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Lélia Batista de
authors.initials: LB
authors.lastname: Souza
authors.affiliation: Department of Oral Pathology, UFRN - Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Leão Pereira
authors.initials: LP
authors.lastname: Pinto
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D002462:Cell Membrane / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D051272:Glucose Transporter Type 1 / Q000032:analysis*; D051274:Glucose Transporter Type 3 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008048:Lip Neoplasms / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D007633:Keratins