title: Synthesis, analgesic, anti-inflammatory and anti-ulcerogenic activities of certain novel Schiff's bases as fenamate isosteres.
abstract: A series of certain novel Schiff bases as fenamate isosteres (VI:a-k) were synthesized to locate analgesic, anti-inflammatory agent with minimal ulcerogenic potential. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis as well as IR, and NMR and mass spectroscopic data. All the compounds were evaluated for their anti-inflammatory activity by carrageenan induced paw oedema method. The compounds possessing good anti-inflammatory activity were further tested for analgesic, ulcerogenic, lipid peroxidation potentials and liver toxicity. Compounds (VI-c), (VI-f), (VI-h) and (VI-i) showed the best anti-inflammatory and significant analgesic activities at doses comparable to that of the standard drug Indomethacin. However, compounds (VI-c) and (VI-f) could be considered the most potent anti-inflammatory and analgesic molecules with maximum reduction in gastro-intestinal ulceration with no hepatocyte necrosis or liver degeneration.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia. Electronic address: a.alafeefy@sau.edu.sa.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Alafeefy
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Bakht
authors.affiliation: Department of Pharmacology and Toxicology, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia.
authors.forename: Majid A
authors.initials: MA
authors.lastname: Ganaie
authors.affiliation: Department of Pharmacology and Toxicology, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia.
authors.forename: Mohd N
authors.initials: MN
authors.lastname: Ansarie
authors.affiliation: Department of Chemistry, College of Science, "Girls Section", King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; National Organization for Drug Control and Research, Giza 35521, Egypt.
authors.forename: Nahed N
authors.initials: NN
authors.lastname: El-Sayed
authors.affiliation: Department of Pharmacognosy, College of Pharmacy 'Girls Section', Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia.
authors.forename: Amani S
authors.initials: AS
authors.lastname: Awaad
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D054361:Fenamates / Q000138:chemical synthesis* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D012545:Schiff Bases / Q000138:chemical synthesis / Q000627:therapeutic use; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D054361:Fenamates; D012545:Schiff Bases
keywords: Analgesic; Anti-inflammatory; Anti-ulcerogenic; Fenamate isostere; Schiff’s bases; Synthesis