title: Three-dimensional vascular imaging of proliferative diabetic retinopathy by Doppler optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the 3-dimensional architecture of neovascularization in proliferative diabetic retinopathy using Doppler optical coherence tomography (OCT).
  
  
  METHODS
  Prospective, nonrandomized clinical trial.
  
  
  METHODS
  Seventeen eyes of 14 patients with proliferative diabetic retinopathy were prospectively studied. Prototype Doppler OCT was used to evaluate the 3-dimensional vascular architecture at vitreoretinal adhesions.
  
  
  RESULTS
  Proliferative membranes were detected in all eyes with proliferative diabetic retinopathy by standard OCT images. Doppler OCT images detected blood flow by neovascularization of the disc in 12 eyes and neovascularization elsewhere in 11 eyes. Doppler OCT images showed the 3-dimensional extent of new vessels at various stages of neovascularization, and the extent of new vessels could be clearly confirmed at vitreoretinal adhesions.
  
  
  CONCLUSIONS
  Doppler OCT is useful for the detection and evaluation of the 3-dimensional vascular structure of neovascularization, and can assist in the noninvasive assessment of proliferative diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. Electronic address: m-miura@tokyo-med.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.affiliation: Computational Optics Group, University of Tsukuba, Ibaraki, Japan.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Computational Optics Group, University of Tsukuba, Ibaraki, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Muramatsu
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002199:Capillary Permeability; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000503:physiopathology; D004301:Doppler Effect; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply; D011446:Prospective Studies; D012039:Regional Blood Flow; D015861:Retinal Neovascularization / Q000175:diagnosis* / Q000503:physiopathology; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*