title: Assessment and comparison of left ventricular shear in normal and situs inversus totalis hearts by means of magnetic resonance tagging.
abstract: Situs inversus totalis (SIT) is characterized by complete mirroring of gross cardiac anatomy and position combined with an incompletely mirrored myofiber arrangement, being normal at the apex but inverted at the base of the left ventricle (LV). This study relates myocardial structure to mechanical function by analyzing and comparing myocardial deformation patterns of normal and SIT subjects, focusing especially on circumferential-radial shear. In nine control and nine SIT normotensive human subjects, myocardial deformation was assessed from magnetic resonance tagging (MRT) image sequences of five LV short-axis slices. During ejection, no significant difference in either circumferential shortening (εcc) or its axial gradient (Δεcc) is found between corresponding LV levels in control and SIT hearts. Circumferential-radial shear (εcr) has a clear linear trend from apex-to-base in controls, while in SIT it hovers close to zero at all levels. Torsion as well as axial change in εcr (Δεcr) is as in controls in apical sections of SIT hearts but deviates significantly towards the base, changing sign close to the LV equator. Interindividual variability in torsion and Δεcr values is higher in SIT than in controls. Apex-to-base trends of torsion and Δεcr in SIT, changing sign near the LV equator, further substantiate a structural transition in myofiber arrangement close to the LV equator itself. Invariance of εcc and Δεcc patterns between controls and SIT subjects shows that normal LV pump function is achieved in SIT despite partial mirroring of myocardial structure leading to torsional and shear patterns that are far from normality.
authors.affiliation: Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands; and.
authors.forename: Alessandro C
authors.initials: AC
authors.lastname: Rossi
authors.affiliation: Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands; and.
authors.forename: Marieke
authors.initials: M
authors.lastname: Pluijmert
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Peter H M
authors.initials: PH
authors.lastname: Bovendeerd
authors.affiliation: Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands; and.
authors.forename: Wilco
authors.initials: W
authors.lastname: Kroon
authors.affiliation: Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands; and.
authors.forename: Theo
authors.initials: T
authors.lastname: Arts
authors.affiliation: Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands; and tammo.delhaas@maastrichtuniversity.nl.
authors.forename: Tammo
authors.initials: T
authors.lastname: Delhaas
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000502:physiology; D033081:Shear Strength; D012857:Situs Inversus / Q000473:pathology / Q000503:physiopathology*; D054159:Torsion, Mechanical
keywords: magnetic resonance tagging; myocardial contraction; myocardial shear; myofiber architecture; situs inversus