title: US valuation of health outcomes measured using the PROMIS-29.
abstract: OBJECTIVE
  Health valuation studies enhance economic evaluations of treatments by estimating the value of health-related quality of life (HRQOL). The Patient-Reported Outcomes Measurement Information System (PROMIS) includes a 29-item short-form HRQOL measure, the PROMIS-29.
  
  
  METHODS
  To value PROMIS-29 responses on a quality-adjusted life-year scale, we conducted a national survey (N = 7557) using quota sampling based on the US 2010 Census. Based on 541 paired comparisons with over 350 responses each, pair-specific probabilities were incorporated into a weighted least-squared estimator.
  
  
  RESULTS
  All losses in HRQOL influenced choice; however, respondents valued losses in physical function, anxiety, depression, sleep, and pain more than those in fatigue and social functioning.
  
  
  CONCLUSIONS
  This article introduces a novel approach to valuing HRQOL for economic evaluations using paired comparisons and provides a tool to translate PROMIS-29 responses into quality-adjusted life-years.
authors.affiliation: Health Outcomes and Behavior, Moffitt Cancer Center and University of South Florida, Tampa, FL, USA. Electronic address: benjamin.craig@moffitt.org.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Craig
authors.affiliation: Department of Health Policy and Management, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Bryce B
authors.initials: BB
authors.lastname: Reeve
authors.affiliation: School of Social Sciences, Humanities and Arts, University of California, Merced, Merced, CA, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Brown
authors.affiliation: Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: David
authors.initials: D
authors.lastname: Cella
authors.affiliation: Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; RAND, Health Program, Santa Monica, CA, USA.
authors.forename: Ron D
authors.initials: RD
authors.lastname: Hays
authors.affiliation: Department of Health and Policy Management, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Lipscomb
authors.affiliation: Department of Pharmacy Systems, Outcomes and Policy, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Simon Pickard
authors.affiliation: Outcomes Research, Evidera, Bethesda, MD, USA.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Revicki
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000523:psychology; D002755:Choice Behavior; D003863:Depression / Q000523:psychology; D005221:Fatigue / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D010146:Pain / Q000523:psychology; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D019057:Quality-Adjusted Life Years; D015203:Reproducibility of Results; D012890:Sleep; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: discrete choice experiments; patient-reported outcomes; quality-adjusted life-years