title: Fatal Anaphylactic Shock Ceftriaxone-Induced in a 4-Year-Old Child.
abstract: One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).
authors.affiliation: From the *Department of Clinical and Experimental Medicine, Section of Pharmacology; †Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Messina; ‡Department of Biotechnology and Legal Medicine, Section of Legal Medicine, University of Palermo, Palermo; §Department of Drug Sciences and Health Products, University of Messina; ∥IRCCS Centro Neurolesi "Bonino-Pulejo", Messina; and ¶Institute of Biomedicine and MolecularImmunology "A. Monroy" (IBIM)-Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy.
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Calapai
authors.forename: Selene
authors.initials: S
authors.lastname: Imbesi
authors.forename: Elvira
authors.initials: E
authors.lastname: Ventura-Spagnolo
authors.forename: Viviana
authors.initials: V
authors.lastname: Cafeo
authors.forename: Livio
authors.initials: L
authors.lastname: Milone
authors.forename: Michele
authors.initials: M
authors.lastname: Navarra
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000276:immunology; D001344:Autopsy / Q000379:methods; D002443:Ceftriaxone / Q000009:adverse effects* / Q000276:immunology; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone