title: A self-assembling lanthanide molecular nanoparticle for optical imaging.
abstract: Chromophores that incorporate f-block elements have considerable potential for use in bioimaging applications because of their advantageous photophysical properties compared to organic dye, which are currently widely used. We are developing new classes of lanthanide-based self-assembling molecular nanoparticles as reporters for imaging and as multi-functional nanoprobes or nanosensors for use with biological samples. One class of these materials, which we call lanthanide "nano-drums", are homogeneous 4d-4f clusters approximately 25 to 30 Å in diameter. These are capable of emitting from the visible to near-infrared wavelengths. Here, we present the synthesis, crystal structure, photophysical properties and comparative cytotoxicity data for a 32 metal Eu-Cd nano-drum [Eu(8)Cd(24)L(12)(OAc)(48)] (1). We also explored the imaging capabilities of this nano-drum using epifluorescence, TIRF, and two-photon microscopy platforms.
authors.affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Brown
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Desmond
authors.initials: D
authors.lastname: Schipper
authors.forename: Justin W
authors.initials: JW
authors.lastname: Hall
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: DePue
authors.forename: Annie J
authors.initials: AJ
authors.lastname: Gnanam
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Arambula
authors.forename: Jessica N
authors.initials: JN
authors.lastname: Jones
authors.forename: Jagannath
authors.initials: J
authors.lastname: Swaminathan
authors.forename: Yakhya
authors.initials: Y
authors.lastname: Dieye
authors.forename: Jamuna
authors.initials: J
authors.lastname: Vadivelu
authors.forename: Don J
authors.initials: DJ
authors.lastname: Chandler
authors.forename: Edward M
authors.initials: EM
authors.lastname: Marcotte
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
authors.forename: Lauren I R
authors.initials: LI
authors.lastname: Ehrlich
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jones
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds