title: Gold-Coated Fe3O4Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging and Therapy.
abstract: The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis and therapy will provide the multimodality needed for accurate diagnosis and targeted therapy. Here, we demonstrate gold-coated iron oxide (Fe3O4@Au) nanoroses with five distinct functions, which integrate aptamer-based targeting, magnetic resonance imaging (MRI), optical imaging, photothermal therapy and chemotherapy into one single probe. The inner Fe3O4core functions as an MRI agent, while the photothermal effect is achieved through near-infrared absorption by the gold shell, causing a rapid rise in temperature and also resulting in a facilitated release of the anticancer drug doxorubicin carried by the nanoroses. Where the doxorubicin is released is monitored by its fluorescent. Aptamers immobilized on the surfaces of the nanoroses enable efficient and selective drug delivery, imaging and photothermal effect with high specificity. The five-function-embedded nanoroses show great advantages in multimodality.
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States; Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, College of Pharmaceutical Science, Southwest University, Chongqing 400715, (P.R. China).
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Ismail
authors.initials: I
authors.lastname: Ocsoy
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Emir
authors.initials: E
authors.lastname: Yasun
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Mingxu
authors.initials: M
authors.lastname: You
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States.
authors.forename: Cuichen
authors.initials: C
authors.lastname: Wu
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States; Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States; Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, College of Pharmaceutical Science, Southwest University, Chongqing 400715, (P.R. China).
authors.forename: Erqun
authors.initials: E
authors.lastname: Song
authors.affiliation: Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, College of Pharmaceutical Science, Southwest University, Chongqing 400715, (P.R. China).
authors.forename: Cheng Zhi
authors.initials: CZ
authors.lastname: Huang
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611-7200, United States; Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
keywords: cancer cells; chemotherapy; imaging; nanorose; photothermal therapy