title: Differences between chemical element contents in hyperplastic and nonhyperplastic prostate glands investigated by neutron activation analysis.
abstract: In order to clarify the differences between Ag, Br, Ca, Co, Cr, Fe, Hg, K, Mg, Mn, Na, Rb, Sb, Sc, Se, and Zn contents in hyperplastic (patients with benign prostate hyperplasia (BPH), n = 32) and nonhyperplastic (control group of healthy male inhabitants, n = 32) prostates, an instrumental neutron activation analysis was performed. Mean values (M ± SΕΜ) for mass fraction (mg/kg, dry mass basis) of chemical elements in glands of patients with BPH were the following: Ag, 0.0346 ± 0.0060; Br, 30.4 ± 3.6; Ca, 2030 ± 165; Co, 0.0716 ± 0.0097; Cr, 1.073 ± 0.119; Fe, 130.0 ± 7.9; Hg, 0.232 ± 0.030; K, 14,470 ± 740; Mg, 1200 ± 80; Mn, 1.19 ± 0.09; Na, 11,610 ± 870; Rb, 14.7 ± 0.8; Sb, 0.163 ± 0.025; Sc, 0.0257 ± 0.0040; Se, 1.243 ± 0.079; and Zn, 1235 ± 92. It was observed that in BPH tissue, the mass fraction of Co (p < 0.015), Cr (p < 0.0002), Hg (p < 0.000007), K (p < 0.001), Rb (p < 0.048), Sb (p < 0.0001), and Se (p < 0.000001) were significantly higher than in controls. In the sixth to eighth decades, the mass fractions of almost all chemical elements in hyperplastic prostates did not depend from age. Our finding of correlation between pairs of prostatic chemical element mass fractions indicates that there is a great disturbance of prostatic chemical element relationships with a benign hyperplastic transformation. The results apparently confirm the disturbed homeostasis of Zn and Se and some other chemical elements in the etiology of BPH.
authors.affiliation: Radionuclide Diagnostics Department, Medical Radiological Research Centre, Koroleva St.-4, Obninsk, 249036, Kaluga Region, Russia, vezai@obninsk.com.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zaichick
authors.forename: Sofia
authors.initials: S
authors.lastname: Zaichick
authors.forename: German
authors.initials: G
authors.lastname: Davydov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001966:Bromine / Q000032:analysis; D002118:Calcium / Q000032:analysis; D002857:Chromium / Q000032:analysis; D003035:Cobalt / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis; D008274:Magnesium / Q000032:analysis; D008297:Male; D008628:Mercury / Q000032:analysis; D019216:Metals, Heavy / Q000032:analysis; D008875:Middle Aged; D009501:Neutron Activation Analysis / Q000379:methods*; D011188:Potassium / Q000032:analysis; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D012643:Selenium / Q000032:analysis; D012834:Silver / Q000032:analysis; D012964:Sodium / Q000032:analysis; D015032:Zinc / Q000032:analysis
chemical_list: D019216:Metals, Heavy; D002857:Chromium; D003035:Cobalt; D012834:Silver; D012964:Sodium; D007501:Iron; D008628:Mercury; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D001966:Bromine; D002118:Calcium