title: Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease.
abstract: Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
authors.affiliation: Mount Sinai Heart, Cardiometabolic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: robert.rosenson@mssm.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Rosenson
authors.affiliation: Division of Cardiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Davidson
authors.affiliation: Mount Sinai Heart, Mount Sinai Hospital, New York, New York.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Hirsh
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kathiresan
authors.affiliation: ECOGENE-21 and Lipid Clinic, Department of Medicine, Université de Montreal, Chicoutimi, Quebec, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gaudet
mesh_terms: D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D005215:Fasting; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000627:therapeutic use; D014644:Genetic Variation; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D015228:Hypertriglyceridemia / Q000175:diagnosis / Q000188:drug therapy; D007249:Inflammation / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D019518:Postprandial Period; D017422:Sequence Analysis, DNA; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D015525:Fatty Acids, Omega-3; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins; D014280:Triglycerides
keywords: atherosclerosis; cardiovascular disease; genetics; triglyceride; triglyceride-rich lipoproteins