title: Au-nanomaterials as a superior choice for near-infrared photothermal therapy.
abstract: Photothermal therapy (PPT) is a platform to fight cancer by using multiplexed interactive plasmonic nanomaterials as probes in combination with the excellent therapeutic performance of near-infrared (NIR) light. With recent rapid developments in optics and nanotechnology, plasmonic materials have potential in cancer diagnosis and treatment, but there are some concerns regarding their clinical use. The primary concerns include the design of plasmonic nanomaterials which are taken up by the tissues, perform their function and then clear out from the body. Gold nanoparticles (Au NPs) can be developed in different morphologies and functionalized to assist the photothermal therapy in a way that they have clinical value. This review outlines the diverse Au morphologies, their distinctive characteristics, concerns and limitations to provide an idea of the requirements in the field of NIR-based therapeutics.
authors.affiliation: Division of Analytical Chemistry, Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. fahmida-09-07@hotmail.com.
authors.forename: Fahmida
authors.initials: F
authors.lastname: Jabeen
authors.affiliation: Division of Analytical Chemistry, Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. najamulhaq@bzu.edu.pk.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Najam-ul-Haq
authors.affiliation: Division of Analytical Chemistry, Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. rabiapuic@gmail.com.
authors.forename: Rabia
authors.initials: R
authors.lastname: Javeed
authors.affiliation: Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innrain 80-82. Innsbruck 6020, Austria. christian.w.huck@uibk.ac.at.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Huck
authors.affiliation: Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innrain 80-82. Innsbruck 6020, Austria. guenther.bonn@uibk.ac.at.
authors.forename: Guenther K
authors.initials: GK
authors.lastname: Bonn
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy; D010789:Phototherapy / Q000379:methods; D019265:Spectroscopy, Near-Infrared
chemical_list: D058185:Magnetite Nanoparticles; D006046:Gold