title: Blocking monoclonal antibodies of TIM proteins as orchestrators of anti-tumor immune response.
abstract: Monoclonal antibody (mAb)-based treatment of cancer has a significant effect on current practice in medical oncology, and is considered now as one of the most successful therapeutic strategies for cancer treatment. MAbs are designed to initiate or enhance anti-tumor immune responses, which can be achieved by either blocking inhibitory immune checkpoint molecules or triggering activating receptors. TIM gene family members are type-I surface molecules expressed in immune cells, and play important roles in the regulation of both innate and adaptive arms of the immune system. Therapeutic strategies based on anti-TIMs mAbs have shown promising results in experimental tumor models, and synergistic combinations of anti-TIMs mAbs with cancer vaccines, adoptive T-cell therapy, radiotherapy and chemotherapy will have great impact on cancer treatment in future clinical development.
authors.affiliation: a Division of Immunobiology; Institute for Genetic Medicine ; Hokkaido University ; Sapporo , Japan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Baghdadi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Haruka
authors.initials: H
authors.lastname: Wada
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Seino
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000276:immunology* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D019138:Antibodies, Blocking; D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines; D008565:Membrane Proteins; C512411:TIMD4 protein, human
keywords: TIM family proteins; antitumor immune response; cancer vaccines; chemotherapy; tumor immunity