title: Efficient Approach To Discover Novel Agrochemical Candidates: Intermediate Derivatization Method.
abstract: Intensive competition of intellectual property, easy development of agrochemical resistance, and stricter regulations of environmental concerns make the successful rate for agrochemical discovery extremely lower using traditional agrochemical discovery methods. Therefore, there is an urgent need to find a novel approach to guide agrochemical discovery with high efficiency to quickly keep pace with the changing market. On the basis of these situations, here we summarize the intermediate derivatization method (IDM) between conventional methods in agrochemicals and novel ones in pharmaceuticals. This method is relatively efficient with short time in discovery phase, reduced cost, especially good innovated structure, and better performance. In this paper, we summarize and illustrate "what is the IDM" and "why to use" and "how to use" it to accelerate the discovery of new biologically active molecules, focusing on agrochemicals. Furthermore, we display several research projects in our novel agrochemical discovery programs with improved success rate under guidance of this strategy in recent years.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Changling
authors.initials: C
authors.lastname: Liu
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Aiying
authors.initials: A
authors.lastname: Guan
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Baoshan
authors.initials: B
authors.lastname: Chai
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Huichao
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
mesh_terms: D016573:Agrochemicals / Q000737:chemistry*; D002622:Chemistry, Agricultural / Q000379:methods*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D016573:Agrochemicals; D010936:Plant Extracts
keywords: intermediate derivatization method; lower cost; new agrochemical discovery; patentable novel structure; shorter discovery phase