title: [Pulmonary function of children with acute leukemia in maintenance phase of chemotherapy].
abstract: OBJECTIVE
  The aim of this study was to assess the pulmonary function of children with acute leukemia.
  
  
  METHODS
  Cross-sectional observational analytical study that enrolled 34 children divided into groups A (17 with acute leukemia in the maintenance phase of chemotherapy) and B (17 healthy children). The groups were matched for sex, age and height. Spirometry was measured using a spirometer Microloop Viasys(®) in accordance with American Thoracic Society and European Respiratory Society guidelines. Maximal respiratory pressures were measured with an MVD300 digital manometer (Globalmed(®)). Maximal inspiratory pressures and maximal expiratory pressures were measured from residual volume and total lung capacity, respectively.
  
  
  RESULTS
  Group A showed a significant decrease in maximal inspiratory pressures when compared to group B. No significant difference was found between the spirometric values of the two groups, nor was there any difference between maximal inspiratory pressure and maximal expiratory pressure values in group A compared to the lower limit values proposed as reference.
  
  
  CONCLUSIONS
  Children with acute leukemia, myeloid or lymphoid, during the maintenance phase of chemotherapy exhibited unchanged spirometric variables and maximal expiratory pressure; However, there was a decrease in inspiratory muscle strength.
authors.affiliation: Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
authors.forename: Thalita Medeiros Fernandes
authors.initials: TM
authors.lastname: de Macêdo
authors.affiliation: Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
authors.forename: Tania Fernandes
authors.initials: TF
authors.lastname: Campos
authors.affiliation: Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
authors.forename: Raquel Emanuele de França
authors.initials: RE
authors.lastname: Mendes
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Danielle Corrêa
authors.initials: DC
authors.lastname: França
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Gabriela Suéllen da Silva
authors.initials: GS
authors.lastname: Chaves
authors.affiliation: Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil. Electronic address: kmorganna@ufrnet.br.
authors.forename: Karla Morganna Pereira Pinto
authors.initials: KM
authors.lastname: de Mendonça
mesh_terms: D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000503:physiopathology*; D060046:Maintenance Chemotherapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000503:physiopathology*; D013147:Spirometry
keywords: Child; Criança; Espirometria; Leucemia; Leukemia; Músculos respiratórios; Respiratory muscles; Respiratory system; Sistema respiratório; Spirometry