title: Frequency of fungal agents identified in sinus samples from patients with clinically suspected rhinosinusitis.
abstract: Fungal rhinosinusitis (FRS) is one of the most important rhinosinusoidal disorders, which involves a variety of etiological agents. We carried out a study to determine the frequency of fungal agents in sinus samples from patients with clinically suspected rhinosinusitis (RS). A total of 205 clinical samples were assessed from 174 patients with clinically suspected RS, of which 48 were positive for microscopic examination and culture, 47 were positive for direct examination but negative by culture, 4 were negative for direct examination but positive by culture, and 106 were negative for both methodologies. The main fungal agents isolated were Aspergillus spp. (32.7%), followed by Schizophyllum commune (28.8%). Sensitivity and specificity of the direct examination were 92.3% and 69.3%, respectively, and concordance between the direct examination and culture was 48.4%. This study indicated that both Aspergillus and S. commune appear to be the most important agents involved in the development of FRS.
authors.affiliation: Medical and Experimental Mycology Unit, Corporación para Investigaciones Biológicas (CIB), Carrera 72A No. 78 B 141, Medellín, Colombia.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Zuluaga
authors.affiliation: School of Microbiology, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ospina-Medina
authors.affiliation: School of Microbiology, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia.
authors.forename: Isabel
authors.initials: I
authors.lastname: Castaño-Gallego
authors.affiliation: Medical and Experimental Mycology Unit, Corporación para Investigaciones Biológicas (CIB), Carrera 72A No. 78 B 141, Medellín, Colombia.
authors.forename: Karen
authors.initials: K
authors.lastname: Arango
authors.affiliation: Basica and Applied Microbiology Research Group (MICROBA), School of Microbiology, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia. Electronic address: angelgonzalezmarin1972@gmail.com.
authors.forename: Ángel
authors.initials: Á
authors.lastname: González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003430:Cross-Sectional Studies; D003955:Diagnostic Tests, Routine; D005260:Female; D005658:Fungi / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008828:Microbiological Techniques; D008853:Microscopy; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology*; D012189:Retrospective Studies; D012220:Rhinitis / Q000453:epidemiology* / Q000209:etiology*; D012680:Sensitivity and Specificity; D012852:Sinusitis / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult
keywords: Aspergillus spp; Fungal infection; Fungal rhinosinusitis; Rhinosinusitis; Schizophyllum commune