title: Aging alters visual processing of objects and shapes in inferotemporal cortex in monkeys.
abstract: Visual perception declines with age. Perceptual deficits may originate not only in the optical system serving vision but also in the neural machinery processing visual information. Since homologies between monkey and human vision permit extrapolation from monkeys to humans, data from young, middle aged and old monkeys were analyzed to show age-related changes in the neuronal activity in the inferotemporal cortex, which is critical for object and shape vision. We found an increased neuronal response latency, and a decrease in the stimulus selectivity in the older animals and suggest that these changes may underlie the perceptual uncertainties found frequently in the elderly.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary; Department of Neurology, Faculty of Medicine, Semmelweis u. 6, H-6725 Szeged, Hungary. Electronic address: cseteg@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Csete
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. Electronic address: annab89@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Bognár
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. Electronic address: csibripeter@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Csibri
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. Electronic address: kaposvari.peter@med.u-szeged.hu.
authors.forename: P
authors.initials: P
authors.lastname: Kaposvári
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. Electronic address: sary.gyula@med.u-szeged.hu.
authors.forename: Gy
authors.initials: G
authors.lastname: Sáry
mesh_terms: D000200:Action Potentials; D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D005556:Form Perception / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000254:growth & development / Q000502:physiology*; D013997:Time Factors; D014786:Vision Disorders / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*
keywords: Aging; Inferotemporal cortex; Monkey; Perceptual deficit; Shape vision