title: Comparison of T stage, N stage, multifocality, and bilaterality in papillary thyroid carcinoma patients according to the presence of coexisting lymphocytic thyroiditis.
abstract: OBJECTIVE
  This study aimed to assess the relationship between coexisting lymphocytic thyroiditis and T-N stages of papillary thyroid carcinoma (PTC) by histopathological analysis.
  
  
  METHODS
  The study included 653 patients who underwent thyroid surgery for PTC at our hospital. Each case was classified as either Hashimoto's thyroiditis (HT), non-Hashimoto type of lymphocytic thyroiditis (NHLT), or normal according to the histopathology of thyroid parenchyma. Patient age, gender, surgical modality, location, T stage, N stage, multifocality and bilaterality were compared according to the histopathology.
  
  
  RESULTS
  The prevalence of coexisting lymphocytic thyroiditis was 25.8% (169/653); HT (7.5%, 49/653) and NHLT (18.3%, 120/653). There were no significant differences in T stage, N stage, multifocality and bilaterality with regard to coexisting lymphocytic thyroiditis, regardless of whether HT and NHLT were considered collectively or discretely. Primary tumor size (p < 0.0001), location (p = 0.0011), N stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to T stage, and gender (p = 0.0193), primary tumor size (p < 0.0001), T stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to N stage.
  
  
  CONCLUSIONS
  PTC patients with coexisting lymphocytic thyroiditis did not differ from those with normal parenchyma in terms of T stage, N stage, multifocality and bilaterality.
authors.affiliation: Department of Radiology .
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Park
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Ha Kyung
authors.initials: HK
authors.lastname: Park
authors.forename: Tae Kwun
authors.initials: TK
authors.lastname: Ha
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jung
authors.forename: Do Hun
authors.initials: DH
authors.lastname: Kim
authors.forename: Sang Kyun
authors.initials: SK
authors.lastname: Bae
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
keywords: Hashimoto’s thyroiditis; TNM stage; Thyroid; lymphocytic thyroiditis; papillary thyroid carcinoma