title: Co-expression of CD40/CD40L on XG1 multiple myeloma cells promotes IL-6 autocrine function.
abstract: Multiple myeloma (MM) is characterized by uncontrolled proliferation of malignant plasma cells in the bone marrow and peripheral blood. Here, we found that CD40 and CD40L co-expressed on XG1 MM cells and the coordinated expression of CD40-CD40L was critical for production and autocrine IL-6 in XG1 cells. Furthermore, TNF-α enhanced the expression of both CD40 and CD40L expression on XG1 cells. We also found that persistent CD40L/CD40 signaling was required for the constitutive activation of NF-κB in the cells.
authors.affiliation: Oncology Institute, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital, Changzhou, China,1.
authors.forename: Chunjian
authors.initials: C
authors.lastname: Qi
authors.forename: Shengwang
authors.initials: S
authors.lastname: Tian
authors.forename: Jiangfang
authors.initials: J
authors.lastname: Wang
authors.forename: Hongbin
authors.initials: H
authors.lastname: Ma
authors.forename: Keqing
authors.initials: K
authors.lastname: Qian
authors.forename: Xueguang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000502:physiology; D019898:Autocrine Communication / Q000502:physiology*; D019013:CD40 Antigens / Q000378:metabolism*; D023201:CD40 Ligand / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D009101:Multiple Myeloma / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D019013:CD40 Antigens; C508600:IL6 protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D023201:CD40 Ligand
keywords: Autocrine; CD40; Co-expression; Multiple Myeloma