title: Vitamin D status and incidence of tuberculosis among contacts of pulmonary tuberculosis patients.
abstract: A prospective cohort study was conducted from 2009 to 2012 to assess the relationship between serum baseline 25-hydroxivytamin D (vitamin D) status and the incidence of tuberculosis (TB) among 572 contacts of 89 pulmonary TB patients in Castellon, Spain. Three new cases of pulmonary TB occurred, with an incidence density of 3.6 per 1000 person-years. Mean vitamin D status was 13.7 ng/ml for cases and 25.7 ng/ml for non-cases. Vitamin D status showed a significant inverse association with TB incidence (adjusted HR 0.88, 95%CI 0.80-0.97). This result is in line with the hypothesis that vitamin D deficiency is associated with TB incidence.
authors.affiliation: Epidemiology Division, Public Health Centre, Castellón, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Arnedo-Pena
authors.affiliation: Biochemical Laboratory, Hospital General, Castellón, Spain.
authors.forename: J V
authors.initials: JV
authors.lastname: Juan-Cerdán
authors.affiliation: Epidemiology Division, Public Health Centre, Castellón, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Romeu-García
authors.affiliation: Biochemical Laboratory, Hospital General, Castellón, Spain.
authors.forename: D
authors.initials: D
authors.lastname: García-Ferrer
authors.affiliation: Preventive Medicine Service, Hospital La Plana, Vila-real, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Holguín-Gómez
authors.affiliation: Biochemical Laboratory, Hospital General, Castellón, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Iborra-Millet
authors.affiliation: Microbiology Laboratory, Hospital La Plana, Vila-real, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gil-Fortuño
authors.affiliation: Microbiology Laboratory, Hospital General, Castellón, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Gomila-Sard
authors.affiliation: Microbiology Laboratory, Hospital General, Castellón, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Roach-Poblete
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000150:complications / Q000453:epidemiology*; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D014807:Vitamin D