title: Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments.
abstract: Dynamic near infrared microscopy has revealed transient retinal phototropism (TRP) correlated with oblique light stimulation. Here, by developing a hybrid confocal microscopy and optical coherence tomography (OCT), we tested sub-cellular source of the TRP in living frog retina. Dynamic confocal microscopy and OCT consistently revealed photoreceptor outer segments as the anatomic source of the TRP. Further investigation of the TRP can provide insights in better understanding of Stiles-Crawford effect (SCE) on rod and cone systems, and may also promise an intrinsic biomarker for early detection of eye diseases that can produce photoreceptor dysfunction.
authors.forename: Benquan
authors.initials: B
authors.lastname: Wang
authors.forename: Qiuxiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Rongwen
authors.initials: R
authors.lastname: Lu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhi
authors.forename: Xincheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D000818:Animals; D001001:Anura; D005240:Feasibility Studies; D008027:Light; D055214:Retinal Photoreceptor Cell Outer Segment / Q000528:radiation effects*; D041623:Tomography, Optical Coherence