title: [Experimental animal model of multiple sclerosis--transverse investigation of MS pathogenesis for therapeutic intervention].
abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) in which autoreactive T cells ignites downstream pathogenic cascades. The orphan nuclear receptor, NR4A2, is identified to be a selectively upregulated gene in peripheral blood T cells from relapsing-remitting MS patients. Furthermore, selective upregulation of NR4A2 is observed in peripheral blood T cells and CNS-infiltrating T cells upon immunization with myelin peptide in experimental autoimmune encephalomyelitis (EAE). Intriguingly, IL-17 -producing helper T cells exclusively express NR4A2, suggesting that NR4A2 expression represents a pathogenic T cells in autoimmunity. In addition, a NR4A2 blockade by RNA interference ameliorated EAE, implying the intrinsic roles of NR4A2 in MS/EAE, and could serve as a novel therapeutic target of the diseases.
authors.forename: Shinji
authors.initials: S
authors.lastname: Oki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamura
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D023421:Models, Animal; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D034741:RNA, Small Interfering / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D020381:Interleukin-17; D034741:RNA, Small Interfering