title: Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs.
abstract: Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.
authors.forename: Andrés R
authors.initials: AR
authors.lastname: Alcántara
authors.forename: Vittorio
authors.initials: V
authors.lastname: Pace
authors.forename: Pilar
authors.initials: P
authors.lastname: Hoyos
authors.forename: Manuel
authors.initials: M
authors.lastname: Sandoval
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Holzer
authors.affiliation: Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Campus de Moncloa, 30100 Madrid, Spain. mjhernai@ucm.es.
authors.forename: María J
authors.initials: MJ
authors.lastname: Hernáiz
mesh_terms: D000446:Aldehyde-Lyases / Q000737:chemistry* / Q000235:genetics; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism; D001711:Biotransformation; D002175:Candida / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D020600:Gluconobacter oxydans / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D008049:Lipase / Q000737:chemistry* / Q000235:genetics; D015202:Protein Engineering; D011549:Pseudomonas / Q000737:chemistry / Q000201:enzymology / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D005656:Fungal Proteins; D006001:Glycoconjugates; D007004:Hypoglycemic Agents; D008049:Lipase; D006026:Glycoside Hydrolases; D000446:Aldehyde-Lyases