title: Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acids with vinyl halides.
abstract: Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild, operationally simple reaction conditions.
authors.affiliation: Merck Center for Catalysis at Princeton University , Princeton, New Jersey 08544, United States.
authors.forename: Adam
authors.initials: A
authors.lastname: Noble
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: McCarver
authors.forename: David W C
authors.initials: DW
authors.lastname: MacMillan
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D014753:Vinyl Compounds; C569210:vinyl iodide; D009532:Nickel; C003763:vinyl bromide