title: High-resolution 7T fMRI of Human Hippocampal Subfields during Associative Learning.
abstract: Examining the function of individual human hippocampal subfields remains challenging because of their small sizes and convoluted structures. Previous human fMRI studies at 3 T have successfully detected differences in activation between hippocampal cornu ammonis (CA) field CA1, combined CA2, CA3, and dentate gyrus (DG) region (CA23DG), and the subiculum during associative memory tasks. In this study, we investigated hippocampal subfield activity in healthy participants using an associative memory paradigm during high-resolution fMRI scanning at 7 T. We were able to localize fMRI activity to anterior CA2 and CA3 during learning and to the posterior CA2 field, the CA1, and the posterior subiculum during retrieval of novel associations. These results provide insight into more specific human hippocampal subfield functions underlying learning and memory and a unique opportunity for future investigations of hippocampal subfield function in healthy individuals as well as those suffering from neurodegenerative diseases.
authors.affiliation: University of California, Los Angeles.
authors.forename: Nanthia A
authors.initials: NA
authors.lastname: Suthana
authors.forename: Markus
authors.initials: M
authors.lastname: Donix
authors.forename: David R
authors.initials: DR
authors.lastname: Wozny
authors.forename: Adam
authors.initials: A
authors.lastname: Bazih
authors.forename: Michael
authors.initials: M
authors.lastname: Jones
authors.forename: Robin M
authors.initials: RM
authors.lastname: Heidemann
authors.forename: Robert
authors.initials: R
authors.lastname: Trampel
authors.forename: Arne D
authors.initials: AD
authors.lastname: Ekstrom
authors.forename: Maria
authors.initials: M
authors.lastname: Scharf
authors.forename: Barbara
authors.initials: B
authors.lastname: Knowlton
authors.forename: Robert
authors.initials: R
authors.lastname: Turner
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
mesh_terms: D000328:Adult; D001245:Association Learning / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D055815:Young Adult