title: [Cryopreservation of testicular tissue in children].
abstract: The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rives
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Milazzo
authors.forename: Albanne
authors.initials: A
authors.lastname: Travers
authors.forename: Brahim
authors.initials: B
authors.lastname: Arkoun
authors.forename: Amandine
authors.initials: A
authors.lastname: Bironneau
authors.forename: Louis
authors.initials: L
authors.lastname: Sibert
authors.forename: Agnès
authors.initials: A
authors.lastname: Liard-Zmuda
authors.forename: Aude
authors.initials: A
authors.lastname: Marie-Cardine
authors.forename: Pascale
authors.initials: P
authors.lastname: Schneider
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vannier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Macé
mesh_terms: D000293:Adolescent; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation / Q000379:methods; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007223:Infant; D007248:Infertility, Male / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009369:Neoplasms / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D012092:Replantation; D012671:Seminiferous Tubules; D013093:Spermatogonia; D013737:Testis / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery*; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic
chemical_list: D000970:Antineoplastic Agents