title: Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans.
abstract: Oral 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid was used to determine whether an increase in cardiac dietary fatty acid (DFA) metabolism in impaired glucose tolerance (IGT) is different in men and women. Myocardial DFA partitioning after 6 h was higher in IGT versus control subjects (P = 0.006) in both men (2.14 [95% CI 1.70-2.18] vs. 1.28 standard uptake value [SUV] units [0.80-1.76]) and women (1.95 [1.57-2.33] vs. 1.64 SUV units [1.32-1.96]) without difference between sexes. Myocardial DFA fractional uptake (Ki) between time 90 and 120 min postprandially was also higher in IGT versus control subjects (P < 0.001) in men (0.063 [0.032-0.095] vs. 0.016 min(-1) [0.007-0.025]) and women (0.050 [0.024-0.077] vs. 0.030 min(-1) [0.013-0.047]) without significant sex difference. Men had higher net myocardial DFA uptake between time 90 and 120 min driven by higher chylomicron-triglyceride (TG) levels. IGT-associated increased cardiac DFA partitioning was directly related to obesity in women, whereas it was associated with IGT per se in men. We conclude that early cardiac DFA uptake is higher in men driven by change in postprandial chylomicron-TG level but that increase in 6-h postprandial cardiac DFA partitioning nevertheless occurs with IGT both in men and women.
authors.affiliation: Department of Medicine, Division of Endocrinology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Margaret
authors.initials: M
authors.lastname: Kunach
authors.affiliation: Department of Medicine, Division of Endocrinology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Christophe
authors.initials: C
authors.lastname: Noll
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Phoenix
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Guérin
authors.affiliation: Department of Medicine, Division of Endocrinology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Jean-Patrice
authors.initials: JP
authors.lastname: Baillargeon
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Eric E
authors.initials: EE
authors.lastname: Turcotte
authors.affiliation: Department of Medicine, Division of Endocrinology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada andre.carpentier@usherbrooke.ca.
authors.forename: André C
authors.initials: AC
authors.lastname: Carpentier
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D005227:Fatty Acids / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes; D018149:Glucose Intolerance / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D049268:Positron-Emission Tomography; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed
chemical_list: D005227:Fatty Acids; D005462:Fluorine Radioisotopes; C071178:14-fluoro-6-thiaheptadecanoic acid