title: Kaposi-Juliusberg varicelliform eruption in patients suffering from Darier-White Disease: a case report and review of the literature.
abstract: Darier-White Disease (DW), otherwise known as keratosis follicularis, is a rare genodermatosis with autosomal dominant inheritance, characterized by loss of adhesion between epidermal cells and abnormal keratinization. The distinctives lesions of DW Disease include rough papules in seborrheic areas, palmoplantar pits, mucosal involvement, and nail changes. DW Disease can be occasionally associated with bacterial complications, but rarely with viral ones. Kaposi's varicelliform eruption (KVE) is a secondary herpes simplex virus infection that affects patients in the setting of primary dermatologic conditions. KVE, frequently misdiagnosed as impetigo, can be severe, progressing to disseminated infections and potentially life threatening. It occurs with a variety of skin disorders, although association with DW Disease has rarely been reported in the literature. This report describes a case of KVE in a patient suffering from DW Disease, focusing on its clinical course. A review of the literature on KVE including disease associations, pathogenesis, and treatment has been also reported.
authors.affiliation: Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy - a.campanati@univpm.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Molinelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Ricotti
authors.forename: Anna
authors.initials: A
authors.lastname: Campanati
authors.forename: Ivana
authors.initials: I
authors.lastname: Cataldi
authors.forename: Giulia
authors.initials: G
authors.lastname: Ganzetti
authors.forename: Giulia
authors.initials: G
authors.lastname: Liberati
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bianchelli
authors.forename: Annamaria
authors.initials: A
authors.lastname: Offidani
mesh_terms: D007644:Darier Disease / Q000150:complications*; D018450:Disease Progression; D006801:Humans; D007169:Impetigo / Q000175:diagnosis*; D007617:Kaposi Varicelliform Eruption / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D055815:Young Adult