title: Gastrointestinal hormones and gut motility.
abstract: OBJECTIVE
  To summarize the recent findings.
  
  
  RESULTS
  Studies of changes in the plasma levels confirm the earlier concepts, but offer little proof of causal effect. It is increasingly realized that peptides produced in the gut have a paracrine role or an indirect effect via the gut-brain axis. Interest in prokinetic peptide agonists remains high despite the failure of two candidate drugs, but relamorelin and camicinal offer new hope.
  
  
  CONCLUSIONS
  We review the original studies published since January 2013 on peptides produced in the gut and with an effect on gastrointestinal motility.
authors.affiliation: Gut Peptide Laboratory, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
authors.forename: Theo L
authors.initials: TL
authors.lastname: Peeters
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D004195:Disease Models, Animal; D017615:Enteric Nervous System / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000378:metabolism* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D051379:Mice
chemical_list: D005768:Gastrointestinal Hormones