title: Age and gender effects on submental motor-evoked potentials.
abstract: It is not known whether there are age- and/or gender-related differences in magnitude of motor-evoked potentials (MEPs) of the submental muscles. Knowledge of this is important in investigations of neurophysiological aspects of swallowing. Forty healthy participants (20 males, 20 females; 20 young [21-35 years], 20 old [53-88 years]) were recruited. Surface electromyography (EMG) electrodes were placed at midline underlying the submental muscle group. Age- and gender-related differences were evaluated in two neurophysiologic measures of swallowing: MEPs stimulated by single-pulse transcranial magnetic stimulation (TMS) over the motor cortex and surface electromyography (sEMG) recorded from the same submental muscle group during non-stimulated swallows. The older participants had larger MEPs during saliva swallowing than the young participants (p = 0.04, d = 0.86). Conversely, the older participants had lower amplitude submental EMG activity during non-stimulated swallows (p = 0.045, d = 0.67). Gender had no significant effect on MEP magnitude and on submental activity during saliva swallowing. There were no effects of age or gender on MEP latencies. These findings suggest deterioration in muscle function with age in a sample of healthy adults presenting with functional swallowing. We speculate that muscular decline is partially ameliorated by increased cortical activity-i.e., increased submental MEPs-so as to preserve swallowing function in healthy older subjects. These findings emphasize the need for different reference points for evaluation of submental MEPs of different age groups.
authors.affiliation: New Zealand Brain Research Institute, 66 Stewart St, Christchurch, 8011, New Zealand, oshrat.sella@nzbri.org.
authors.forename: Oshrat
authors.initials: O
authors.lastname: Sella
authors.forename: Richard D
authors.initials: RD
authors.lastname: Jones
authors.forename: Maggie-Lee
authors.initials: ML
authors.lastname: Huckabee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015331:Cohort Studies; D016001:Confidence Intervals; D003679:Deglutition / Q000502:physiology*; D004567:Electrodes, Implanted; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D009334:Neck Muscles / Q000502:physiology*; D009482:Neurophysiology; D009520:New Zealand; D010156:Palatal Muscles / Q000502:physiology; D011446:Prospective Studies; D012016:Reference Values; D012737:Sex Factors; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult