title: Super-enhancer transcription converges on AID.
abstract: AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA.
authors.forename: Jukka
authors.initials: J
authors.lastname: Alinikula
authors.affiliation: Department of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA. Electronic address: david.schatz@yale.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Schatz