title: Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor.
abstract: We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 years after WT therapy consisting of VDA and abdominal XRT. The unlikely co-occurrence of WT and IMT suggests a genetic link between these tumors or that IMT can arise as a complication of cancer therapy. IMT should be considered in WT survivors who develop secondary tumors, especially at unusual sites.
authors.affiliation: Division of Oncology, Children's National Health System, Washington, District of Columbia.
authors.forename: Michael V
authors.initials: MV
authors.lastname: Ortiz
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Rossi
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Guzzetta
authors.forename: Faisal
authors.initials: F
authors.lastname: Qureshi
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dome
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002675:Child, Preschool; D005260:Female; D006104:Granuloma, Plasma Cell / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D009396:Wilms Tumor / Q000150:complications*
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: ALK; Wilms tumor; inflammatory myofibroblastic tumor; second neoplasm