title: The perils of Grandma's medication: colchicine toxicity causing pneumomediastinum.
abstract: A 19 year old male presented with a deliberate overdose of colchicine (50mg). He had no other significant medical history. 36 hours following admission he developed widespread surgical emphysema. An urgent CT scan of his chest and abdomen demonstrated mediastinal gas of lung origin. He also developed bone marrow suppression and disseminated intravascular coagulopathy. He was treated supportively with intravenous fluids, high flow oxygen and intravenous antibiotics and made a full recovery. Colchicine toxicity is a rare, but important presentation with high levels of morbidity and mortality. Pneumomediastinum is a potentially important complication. It may be appropriate to monitor patients in the later stages of the condition through an ambulatory setting.
authors.affiliation: Departments of Acute Medicine and Radiology, University Hospital of South Manchester, Manchester.
authors.forename: E
authors.initials: E
authors.lastname: Shuttleworth
authors.affiliation: Departments of Acute Medicine and Radiology, University Hospital of South Manchester, Manchester.
authors.forename: R
authors.initials: R
authors.lastname: Sawyer
authors.affiliation: Departments of Acute Medicine and Radiology, University Hospital of South Manchester, Manchester.
authors.forename: M
authors.initials: M
authors.lastname: Holland
authors.affiliation: Departments of Acute Medicine and Radiology, University Hospital of South Manchester, Manchester.
authors.forename: T
authors.initials: T
authors.lastname: Cooksley
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003078:Colchicine / Q000633:toxicity*; D062787:Drug Overdose / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008478:Mediastinal Emphysema / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D013352:Subcutaneous Emphysema / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D003078:Colchicine