title: One diffusion acquisition and different white matter models: how does microstructure change in human early development based on WMTI and NODDI?
abstract: White matter microstructural changes during the first three years of healthy brain development are characterized using two different models developed for limited clinical diffusion data: White Matter Tract Integrity (WMTI) metrics from Diffusional Kurtosis Imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI). Both models reveal a non-linear increase in intra-axonal water fraction and in tortuosity of the extra-axonal space as a function of age, in the genu and splenium of the corpus callosum and the posterior limb of the internal capsule. The changes are consistent with expected behavior related to myelination and asynchrony of fiber development. The intra- and extracellular axial diffusivities as estimated with WMTI do not change appreciably in normal brain development. The quantitative differences in parameter estimates between models are examined and explained in the light of each model's assumptions and consequent biases, as highlighted in simulations. Finally, we discuss the feasibility of a model with fewer assumptions.
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA. Electronic address: ileana.jelescu@nyumc.org.
authors.forename: Ileana O
authors.initials: IO
authors.lastname: Jelescu
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Jelle
authors.initials: J
authors.lastname: Veraart
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Vitria
authors.initials: V
authors.lastname: Adisetiyo
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Milla
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Novikov
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Els
authors.initials: E
authors.lastname: Fieremans
mesh_terms: D000375:Aging / Q000502:physiology; D001369:Axons / Q000502:physiology; D003198:Computer Simulation; D003337:Corpus Callosum / Q000254:growth & development / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020772:Internal Capsule / Q000254:growth & development / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D009186:Myelin Sheath / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D016501:Neurites / Q000502:physiology; D066127:White Matter / Q000033:anatomy & histology* / Q000254:growth & development
keywords: Brain development; DKI; Diffusion MRI; Microstructure; Modeling; White matter