title: Initial clinical trial of a novel hemostat, TDM-621, in the endoscopic treatments of the gastric tumors.
abstract: OBJECTIVE
  The feasibility of TDM-621, the synthetic infectious agent-free peptides, was tested in hemostasis of the bleeding after endoscopic treatments of the gastric tumors.
  
  
  METHODS
  The patients who underwent endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) were enrolled in the present study. The subject of hemostasis was the oozing after the EMR or ESD. The hemostatic effect, the secondary hemorrhage from one postoperative day to the day before discharge and operability were studied.
  
  
  RESULTS
  The hemostatic effects were assessed in 12 patients. It was "remarkably effective" in 11 patients and "effective" in 1 patient. The operability was "very easy" in two patients, "easy" in eight patients and "acceptable" in two patients. No secondary hemorrhage was observed in all of 12 patients. No adverse effect considered to be related to TDM-621 was observed.
  
  
  CONCLUSIONS
  It was shown that hemostasis using TDM-621 was feasible after endoscopic treatments of the gastric tumors without any technical trouble or adverse event.
authors.affiliation: Surgery and Digestive Diseases Center, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Naoki
authors.initials: N
authors.lastname: Goto
authors.forename: Minoru
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Koyama
authors.forename: Junko
authors.initials: J
authors.lastname: Kuroda
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Kitahora
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Mikinori
authors.initials: M
authors.lastname: Kataoka
authors.forename: Fujii
authors.initials: F
authors.lastname: Takashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D005773:Gastroscopy / Q000379:methods; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006490:Hemostatics; D010455:Peptides; C581206:acetyl-(arginyl-alanyl-aspartyl-alanyl)4-amide
keywords: bleeding; endoscopic mucosal resection; endoscopic submucosal dissection; gastric cancer; hemostasis