title: Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature.
abstract: This study aims to critically summarize the literature about nano-hydroxyapatite. The purpose of this work is to analyze the benefits of using nano-hydroxyapatite in dentistry, especially for its preventive, restorative and regenerative applications. We also provide an overview of new dental materials, still experimental, which contain the nano-hydroxyapatite in its nano-crystalline form. Hydroxyapatite is one of the most studied biomaterials in the medical field for its proven biocompatibility and for being the main constituent of the mineral part of bone and teeth. In terms of restorative and preventive dentistry, nano-hydroxyapatite has significant remineralizing effects on initial enamel lesions, certainly superior to conventional fluoride, and good results on the sensitivity of the teeth. The nano-HA has also been used as an additive material, in order to improve already existing and widely used dental materials, in the restorative field (experimental addition to conventional glass ionomer cements, that has led to significant improvements in their mechanical properties). Because of its unique properties, such as the ability to chemically bond to bone, to not induce toxicity or inflammation and to stimulate bone growth through a direct action on osteoblasts, nano-HA has been widely used in periodontology and in oral and maxillofacial surgery. Its use in oral implantology, however, is a widely used practice established for years, as this substance has excellent osteoinductive capacity and improves bone-to-implant integration.
authors.affiliation: Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
authors.forename: Erlind
authors.initials: E
authors.lastname: Pepla
authors.affiliation: Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
authors.forename: Lait Kostantinos
authors.initials: LK
authors.lastname: Besharat
authors.affiliation: Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
authors.forename: Gaspare
authors.initials: G
authors.lastname: Palaia
authors.affiliation: Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Tenore
authors.affiliation: Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Migliau
keywords: nano-HA; preventive; regenerative; restorative