title: Citric acid cycle intermediates in cardioprotection.
abstract: Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury.
authors.affiliation: From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Gabor
authors.initials: G
authors.lastname: Czibik
authors.affiliation: From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Violetta
authors.initials: V
authors.lastname: Steeples
authors.affiliation: From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Arash
authors.initials: A
authors.lastname: Yavari
authors.affiliation: From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. houman.ashrafian@cardiov.ox.ac.uk.
authors.forename: Houman
authors.initials: H
authors.lastname: Ashrafian
mesh_terms: D000818:Animals; D002952:Citric Acid Cycle / Q000502:physiology*; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000517:prevention & control; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*
keywords: cardioprotection; citric acid cycle; fumaric acid; nuclear factor (erythroid-derived 2)-like 2; oxidation-reduction; reperfusion injury