title: FRAIL-HF, a study to evaluate the clinical complexity of heart failure in nondependent older patients: rationale, methods and baseline characteristics.
abstract: The clinical scenario of heart failure (HF) in older hospitalized patients is complex and influenced by acute and chronic comorbidities, coexistent geriatric syndromes, the patient's ability for self-care after discharge, and degree of social support. The impact of all these factors on clinical outcomes or disability evolution is not sufficiently known. FRAIL-HF is a prospective observational cohort study designed to evaluate clinical outcomes (mortality and readmission), functional evolution, quality of life, and use of social resources at 1, 3, 6, and 12 months after admission in nondependent elderly patients hospitalized for HF. Clinical features, medical treatment, self-care ability, and health literacy were prospectively evaluated and a comprehensive geriatric assessment with special focus on frailty was systematically performed in hospital to assess interactions and relationships with postdischarge outcomes. Between May 2009 and May 2011, 450 consecutive patients with a mean age of 80 ± 6 years were enrolled. Comorbidity was high (mean Charlson index, 3.4 ± 2.9). Despite being nondependent, 118 (26%) had minor disability for basic activities of daily living, only 76 (16.2%) had no difficulty in walking 400 meters, and 340 (75.5%) were living alone or with another elderly person. In addition, 316 patients (70.2%) fulfilled frailty criteria. Even nondependent older patients hospitalized for HF show a high prevalence of clinical and nonclinical factors that may influence prognosis and are usually not considered in routine clinical practice. The results of FRAIL-HF will provide important information about the relationship between these factors and different postdischarge clinical, functional, and quality-of-life outcomes.
authors.affiliation: Department of Geriatrics, Madrid, Spain.
authors.forename: María T
authors.initials: MT
authors.lastname: Vidán
authors.forename: Elísabet
authors.initials: E
authors.lastname: Sánchez
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
authors.forename: José A
authors.initials: JA
authors.lastname: Serra-Rexach
authors.forename: Javier
authors.initials: J
authors.lastname: Ortiz
authors.forename: Héctor
authors.initials: H
authors.lastname: Bueno
mesh_terms: D000203:Activities of Daily Living; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006333:Heart Failure / Q000401:mortality; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012648:Self Care; D016896:Treatment Outcome; D016138:Walking