title: Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
abstract: The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, (1)H and (13)C NMR), 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409, United States.
authors.forename: Wael A
authors.initials: WA
authors.lastname: Elmasri
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Yang
authors.forename: Phat
authors.initials: P
authors.lastname: Tran
authors.forename: Mohamed-Elamir F
authors.initials: ME
authors.lastname: Hegazy
authors.forename: Abdul N
authors.initials: AN
authors.lastname: Hamood
authors.forename: Yehia
authors.initials: Y
authors.lastname: Mechref
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D004534:Egypt; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010626:Phenylethyl Alcohol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D031367:Teucrium / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D057889:Iridoid Glycosides; D039821:Monoterpenes; D010626:Phenylethyl Alcohol