title: A new companion of elongating RNA Polymerase II: TINTIN, an independent sub-module of NuA4/TIP60 for nucleosome transactions.
abstract: Multiple factors are involved in the elongation stage of transcription regulation to ensure the passing of RNA polymerases while preserving appropriate nucleosome structure thereafter. The recently reported trimeric sub-module of NuA4 histone acetyltransferase complex involved in this process provides more insight into the sophisticated modulation of transcription elongation.
authors.affiliation: a St-Patrick Research Group in Basic Oncology ; Laval University Cancer Research Center and CHU de Quebec Research Center-Oncology Axis ; Hôtel-Dieu de Québec (CHU de Québec); Quebec City , QC Canada.
authors.forename: Xue
authors.initials: X
authors.lastname: Cheng
authors.forename: Jacques
authors.initials: J
authors.lastname: Côté
mesh_terms: D000818:Animals; D051548:Histone Acetyltransferases / Q000378:metabolism; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D009707:Nucleosomes / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D061805:Transcription Elongation, Genetic; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5; C504740:NuA4 protein, S cerevisiae; D012319:RNA Polymerase II
keywords: Eaf3; Eaf5; Eaf7; MRG15; MRGBP; NuA4; TINTIN; acetylation; chromatin; transcription elongation