title: Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles.
abstract: The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After "optimum RF exposure" at 40 W for 5 min, Au-CRC-TRC-NPs dissipated heat energy in the range of ∼42°C, the lower critical solution temperature (LCST) of chitosan-graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
authors.forename: N
authors.initials: N
authors.lastname: Sanoj Rejinold
authors.affiliation: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, South Korea.
authors.forename: Reju George
authors.initials: RG
authors.lastname: Thomas
authors.affiliation: Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, South Korea.
authors.forename: Muthunarayanan
authors.initials: M
authors.lastname: Muthiah
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
authors.forename: K P
authors.initials: KP
authors.lastname: Chennazhi
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
authors.forename: K
authors.initials: K
authors.lastname: Manzoor
authors.affiliation: Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, South Korea. Electronic address: pik96@chonnam.ac.kr.
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
authors.affiliation: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, South Korea.
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Jeong
authors.affiliation: Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India. Electronic address: rjayakumar@aims.amrita.edu.
authors.forename: R
authors.initials: R
authors.lastname: Jayakumar
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002209:Caprolactam / Q000737:chemistry*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage* / Q000494:pharmacology*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D010316:Particle Size; D061208:Pulsed Radiofrequency Treatment; D013816:Thermodynamics; D014018:Tissue Distribution; D047368:Tumor Burden / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002209:Caprolactam; D006046:Gold; D048271:Chitosan; D003474:Curcumin
keywords: Chitosan-graft-PNVCL; Curcumin; Gold; RF therapy; Tumor localization