title: [A comparative analysis of colorectal carcinoma cell lines that differ in metastatic potential].
abstract: In the current work we make an attempt to compare cancer cells of one origin, but differing in the expression of CEA protein, a clinical marker of metastatic carcinomas, presumably one of the key factors in metastatic activity. We have explored the morphology of cell colonies in vitro, expression patterns of epithelial markers, the ability of these cells to form tumors and metastases in vivo, and evaluated their stem compartment with the aid of a suicidal genetic construct sensitive to the embryonic stem cell marker, Oct4.
authors.forename: A P
authors.initials: AP
authors.lastname: Davydov-Sinitsyn
authors.forename: O V
authors.initials: OV
authors.lastname: Bazhenova
authors.forename: M A
authors.initials: MA
authors.lastname: Liskovykh
authors.forename: S V
authors.initials: SV
authors.lastname: Ponomartsev
authors.forename: L L
authors.initials: LL
authors.lastname: Chechik
authors.forename: A N
authors.initials: AN
authors.lastname: Tomilin
authors.forename: E N
authors.initials: EN
authors.lastname: Tolkunova
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002999:Clone Cells; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D005822:Genetic Vectors; D057809:HEK293 Cells; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D050814:Octamer Transcription Factor-3 / Q000235:genetics* / Q000378:metabolism; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human