title: Values of high sensitive troponin T in long-term survivors of childhood cancer treated with anthracyclines.
abstract: BACKGROUND
  Cardiac biomarkers can play an important role in the early detection of subclinical heart failure. Our aims are to 1) obtain values of high sensitive cardiac troponin T (hs-cTnT) in long-term survivors of childhood cancer and 2) investigate the potential role of hs-cTnT in the detection of subclinical late-onset cardiotoxicity.
  
  
  METHODS
  Hs-cTnT and N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) were measured in 64 survivors. Electrocardiography and echocardiography were performed to evaluate cardiac function.
  
  
  RESULTS
  Mean follow-up period was 8.3 years (range of 4.5 to 34.1). All survivors were clinically asymptomatic and had no history of clinical heart failure during or immediately after anthracycline treatment. Electrocardiography (available in 59 of 64 survivors) showed no signs of myocardial injury related to ischemia or abnormal QTc. Echocardiography was performed in all survivors. Mean left ventricular shortening fraction (SF) was 34% (range of 28 to 43%); mean ejection fraction (EF) was 61% (range of 48 to 74%). Seven survivors had a mildly decreased EF between 48% and 55%. Normal hs-cTnT levels were found in all 64 survivors (range of 3 to 13 ng/L) and did not differ among different anthracycline dosage groups: ≤120, 120-300 and ≥300 mg/m(2). Yet, 5/64 survivors had elevated NT-pro-BNP levels (range of 7 to 25 pg/ml) with normal SF and ECG findings and only one mildly abnormal EF of 51%.
  
  
  CONCLUSIONS
  Hs-cTnT concentrations are normal in long-term survivors of childhood cancer, even in the subpopulations with elevated NT-pro-BNP and/or a mildly decreased EF, indicating that it is not a sensitive marker for late onset subclinical anthracycline induced cardiotoxicity.
authors.affiliation: Department of Pediatric Hematology and Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, Huispost 804, 6500 HB Nijmegen, The Netherlands. Electronic address: Milanthy.Pourier@radboudumc.nl.
authors.forename: Milanthy S
authors.initials: MS
authors.lastname: Pourier
authors.affiliation: Children's Heart Center, Radboud University Medical Center Nijmegen, The Netherlands; Pediatric Cardiology Unit, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Livia
authors.initials: L
authors.lastname: Kapusta
authors.affiliation: Department of Pediatric Hematology and Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, Huispost 804, 6500 HB Nijmegen, The Netherlands.
authors.forename: Aniek
authors.initials: A
authors.lastname: van Gennip
authors.affiliation: Department of Pediatric Hematology and Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, Huispost 804, 6500 HB Nijmegen, The Netherlands.
authors.forename: Jos P M
authors.initials: JP
authors.lastname: Bökkerink
authors.affiliation: Department of Pediatric Hematology and Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, Huispost 804, 6500 HB Nijmegen, The Netherlands.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Loonen
authors.affiliation: Department of Cardiology, Radboud University Medical Center Nijmegen, The Netherlands.
authors.forename: Louise
authors.initials: L
authors.lastname: Bellersen
authors.affiliation: Department of Pediatric Hematology and Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, Huispost 804, 6500 HB Nijmegen, The Netherlands.
authors.forename: Annelies M C
authors.initials: AM
authors.lastname: Mavinkurve-Groothuis
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D017741:Survivors; D020107:Troponin T / Q000097:blood*; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D020107:Troponin T
keywords: Anthracycline-induced cardiotoxicity; Biomarker; Childhood cancer; High sensitive troponin T; Late-onset cardiotoxicity