title: Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review.
abstract: BACKGROUND
  Ependymomas are rare glial tumors of the brain representing less than 5% of brain tumors. However, spinal cord ependymomas in adults account for over 60% of all ependymomas including those arising from the filum terminale and only 40% are intracranial. Reports of the appearance of another neoplasia at a different location in patients with spinal ependymoma are scarce.
  
  
  METHODS
  We searched PubMed for studies related to spinal cord ependymomas published over the last 30 years (from January 1984) and retrieved 1197.
  
  
  RESULTS
  We identified only two studies that met our criteria and we found an incidence of 9% of secondary neoplasias after treatment for spinal ependymoma. The neoplasms were diagnosed from 2 months to 20 years after patients underwent surgery for intraspinal ependymoma. These included pancreatic cancer, prostate cancer, Hodgkin lymphoma, intracranial meningioma, mucin-producing pulmonary adenocarcinoma, gastric cancer and astrocytoma.
  
  
  CONCLUSIONS
  The genetic abnormalities affecting patients with spinal ependymomas may indicate a predisposition to the development of secondary cancers or a general failure of the repairing mechanism in their DNA. The unaffected survival rates in those individuals permit for a long period the accumulation of different mutations on the genome and thus the appearance of a second cancer. However, more studies are needed, particularly in young patients with high survival rates.
authors.affiliation: Department of Neurosurgery, University Hospital of Thessaly, University Hospital of Larissa, Biopolis, 41110 Larissa, Thessaly, Greece. gfotakop@yahoo.gr.
authors.forename: George
authors.initials: G
authors.lastname: Fotakopoulos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vagkopoulos
authors.forename: Charalabos
authors.initials: C
authors.lastname: Gatos
authors.forename: Polikceni
authors.initials: P
authors.lastname: Kotlia
authors.forename: Alexandros
authors.initials: A
authors.lastname: Brotis
mesh_terms: D004806:Ependymoma; D006801:Humans; D013120:Spinal Cord Neoplasms