title: Long-range GABAergic neurons in the prefrontal cortex modulate behavior.
abstract: Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519-11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Christian
authors.initials: C
authors.lastname: Bravo-Rivera
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Diehl
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Ciorana
authors.initials: C
authors.lastname: Roman-Ortiz
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Jose
authors.initials: J
authors.lastname: Rodriguez-Romaguera
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Rosas-Vidal
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Hector
authors.initials: H
authors.lastname: Bravo-Rivera
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Quiñones-Laracuente
authors.affiliation: Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico fabriciodomonte@gmail.com.
authors.forename: Fabricio H
authors.initials: FH
authors.lastname: Do-Monte
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D005260:Female; D059330:GABAergic Neurons / Q000166:cytology*; D008297:Male; D009434:Neural Pathways / Q000166:cytology*; D009714:Nucleus Accumbens / Q000166:cytology*; D017397:Prefrontal Cortex / Q000166:cytology*
keywords: amygdala; aversion; avoidance; striatum