title: Interaction between blood selenium concentration and a levels of oxidative stress and antioxidative capacity in healthy children.
abstract: The study aimed at defining the relationship between blood selenium concentration (Se-B) and levels of oxidative stress and antioxidative capacity in healthy children. The studies were conducted on 337 children (mean age: 8.53±1.92 years). The groups of individuals with Se-B <1st quartile (group I, Se-B<70μg/L), with Se-B fitting the range of 1st quartile and median (group II, Se-B: 70-76.9μg/L), with Se-B between the median and 3rd quartile (group III, Se-B: 77-83.9μg/L) and those with Se-B above the 3rd quartile (group IV, Se-B≥84μg/L) were distinguished. Level of oxidative stress was defined using determination of urine malonyldialdehyde concentration (MDA) and urine 8-hydroxy-2-deoxyguanosine concentration (8-OHdg). Urine total antioxidant status (TAS) was determined. In group IV TAS was significantly higher than in groups I-III. A positive correlation was detected between Se-B and TAS. In healthy children an appropriately high Se-B seems to ensure higher total antioxidative status.
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wrocław, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Gać
authors.affiliation: Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, PL 41-200 Sosnowiec, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Pawlas
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wrocław, Poland. Electronic address: sogood@poczta.onet.pl.
authors.forename: Rafał
authors.initials: R
authors.lastname: Poręba
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wrocław, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Poręba
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wrocław, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Markiewicz-Górka
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wrocław, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Januszewska
authors.affiliation: Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, PL 41-200 Sosnowiec, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Olszowy
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wrocław, Poland; Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, PL 41-200 Sosnowiec, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pawlas
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000652:urine*; D018384:Oxidative Stress; D011044:Poland; D012643:Selenium / Q000097:blood*
chemical_list: D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D012643:Selenium
keywords: 8-Hydroxy-2-deoxyguanosine concentration; Antioxidative capacity; Blood selenium concentration; Healthy children; Malonyldialdehyde concentration; Oxidative stress