title: Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report.
abstract: We report the neuroimaging and histopathologic findings of a 12-year-old female patient with a disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural metastatic disease. These tumors may represent distinct pathology primarily seen in pediatric patients. Neuroimaging demonstrates diffuse, progressive enhancement of the leptomeninges often with interval development of intraparenchymal lesions on follow-up. Disease is typically confined to the central nervous system, though diffuse peritoneal disease was seen in our case, possibly through metastatic seeding of the abdomen via ventriculoperitoneal shunt.
authors.affiliation: University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address: Brice_Kessler@med.unc.edu.
authors.forename: Brice A
authors.initials: BA
authors.lastname: Kessler
authors.affiliation: Department of Pathology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: Christine.Bookhout@unchealth.unc.edu.
authors.forename: Christine
authors.initials: C
authors.lastname: Bookhout
authors.affiliation: Department of Neurosurgery, University of North Carolina, Chapel Hill, North Carolina. Electronic address: Sivakumar_Jaikumar@med.unc.edu.
authors.forename: Sivakumar
authors.initials: S
authors.lastname: Jaikumar
authors.affiliation: Department of Pediatric Hematology-Oncology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: HippsJ@email.unc.edu.
authors.forename: John
authors.initials: J
authors.lastname: Hipps
authors.affiliation: Department of Radiology, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, North Carolina. Electronic address: Yueh_Lee@med.unc.edu.
authors.forename: Yueh Z
authors.initials: YZ
authors.lastname: Lee
mesh_terms: D002648:Child; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000473:pathology*; D009366:Neoplasm Seeding; D059906:Neuroimaging; D009837:Oligodendroglioma / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000556:secondary*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
keywords: Leptomeningeal tumor; Oligodendroglial-like tumor; Oncology; Pediatric