title: [Studies on release behavior of sustained release tablets of extracts of Gardenia by antioxidant activity].
abstract: Using sustained release tablets of gardenia extract as model drug and DPPH radical scavenging capacity as antioxidant index, the feasibility of using pharmacodynamics index was explored to evaluate sustained release tablets. Applying the established quantifiable method of DPPH radical scavenging to the dissolved liquid of model drug, release profiles and biological effects profiles were drawn, and their correlation was discussed. A good correlation was observed by linear regression and f2 actor, suggesting that the indicator could be used to evaluate sustained release tabletsofextracts of gardenia in which iridoids were mainly involved.
authors.forename: Yi-wang
authors.initials: YW
authors.lastname: Guo
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Zhao
authors.forename: Yan-ke
authors.initials: YK
authors.lastname: Cheng
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Shou-ying
authors.initials: SY
authors.lastname: Du
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000378:metabolism* / Q000493:pharmacokinetics; D005609:Free Radicals / Q000378:metabolism; D032062:Gardenia / Q000737:chemistry*; D007700:Kinetics; D016014:Linear Models; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism* / Q000493:pharmacokinetics; D013607:Tablets
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D003692:Delayed-Action Preparations; D005609:Free Radicals; D010851:Picrates; D010936:Plant Extracts; D013607:Tablets; C004931:1,1-diphenyl-2-picrylhydrazyl