title: Poly(ethylene glycol)-or silicone-modified hyaluronan for contact lens wetting agent applications.
abstract: Hyaluronan (HA) is a hydrophilic biopolymer that has been explored as a wetting agent in contact lens applications. In this study, HA was modified with siloxy or polyethylene glycol moieties using click chemistry to make it more soluble in monomer solutions used to synthesize model contact lens materials; unmodified HA was not soluble in the same monomer solutions. The water contents of the silicone hydrogels were not increased by the presence of modified HA, nor was there a decrease in the surface contact angle. However, modified HA did lead to a reduction in lysozyme adsorption in some cases. The leaching rate of HA modified with polyethylene glycol from a 78:22 DMA:TRIS(OH) hydrogel was significantly slower than for unmodified HA.
authors.affiliation: Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Paterson
authors.affiliation: Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Lina
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Chemistry, McMaster University, Hamilton, Ontario, Canada.|School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Brook
authors.affiliation: Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.|School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Heather
authors.initials: H
authors.lastname: Sheardown
mesh_terms: D018639:Contact Lens Solutions; D003261:Contact Lenses; D004797:Enzyme-Linked Immunosorbent Assay; D006820:Hyaluronic Acid / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties; D017155:Wettability
chemical_list: D018639:Contact Lens Solutions; D012828:Silicones; D011092:Polyethylene Glycols; D006820:Hyaluronic Acid
keywords: HA; PEG; contact lens; hydrogel; protein fouling