title: [Pathological observation of progressive massive fibrosis in autophy frompatients with coal worker's pneumoconiosis].
abstract: OBJECTIVE
  To study the pathological features of progressive massive fibrosis (PMF) in the lung tissues of patients with coal workers' pneumoconiosis (CWP).
  
  
  METHODS
  A retrospective analysis was made on the autopsies from 8 patients with CWP, which were observed under a microscope by HE staining, given their occupational history.
  
  
  RESULTS
  The age of 8 cases ranged 47-71 years (mean, 59.9 years), and their dust exposure time was 18-32 years (mean, 25.1 years). All the 8 cases were complicated by chronic bronchitis as well as emphysema, 7 cases by pulmonary heart disease, and 4 cases by pulmonary tuberculosis. In this group of patients, PMF was mainly distributed in the hilum and the upper lobe of the lung, including 7 cases of nodular fusion type and 1 case of PMF type. The collagen fibers around PMF extended radially and destroyed its surrounding tissue.
  
  
  CONCLUSIONS
  Nodular fusion type is the main form of PMF in the lung tissues of CWP patients. It has a progressive and destructive process, which is the manifestation of advanced CWP.
authors.affiliation: The Occupational Diesease Hospital of Xin Jiang Uygur Autonomous Region, Urumqi 830091, China.
authors.forename: Ruikang
authors.initials: R
authors.lastname: Jiang
authors.affiliation: The Occupational Diesease Hospital of Xin Jiang Uygur Autonomous Region, Urumqi 830091, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Occupational Diesease Hospital of Xin Jiang Uygur Autonomous Region, Urumqi 830091, China. E-mail: xjgzsswyh@126.com.
authors.forename: Peicheng
authors.initials: P
authors.lastname: Liu
mesh_terms: D000368:Aged; D055008:Anthracosis / Q000473:pathology*; D003032:Coal Mining; D004391:Dust; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D004391:Dust