title: Anti glutamate-decarboxylase antibodies: a liaison between localisation related epilepsy, stiff-person syndrome and type-1 diabetes mellitus.
abstract: We present two patients with partial epilepsy, type-1 diabetes and stiff person syndrome associated with high serum auto-antibody levels to glutamate-decarboxylase (anti-GAD). Both patients were or have suffered from additional autoimmune conditions. The presence of stiff person syndrome and elevated anti-GAD levels have to make clinicians look for additional autoimmune conditions including type-1 diabetes. On the other hand, the co-morbidity of partial epilepsy with autoimmune conditions in patients with elevated serum anti-GAD suggests an autoimmune mechanism of partial epilepsy in these cases.
authors.forename: Anna
authors.initials: A
authors.lastname: Szűcs
authors.forename: Gábor
authors.initials: G
authors.lastname: Barcs
authors.forename: Gábor
authors.initials: G
authors.lastname: Winkler
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Soós
authors.forename: András
authors.initials: A
authors.lastname: Folyovich
authors.forename: Anna
authors.initials: A
authors.lastname: Kelemen
authors.forename: Péter
authors.initials: P
authors.lastname: Várallyay
authors.forename: Anita
authors.initials: A
authors.lastname: Kamondi
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000276:immunology*; D004827:Epilepsy / Q000201:enzymology / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D016750:Stiff-Person Syndrome / Q000201:enzymology / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase