title: Correlation of lower concentrations of hydrogen sulfide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy.
abstract: OBJECTIVE
  To explore the relationship between hydrogen sulfide (H2S) and uremic accelerated atherosclerosis (UAAS) in chronic hemodialysis patients with diabetic nephropathy (CHD/DN).
  
  
  METHODS
  A total of 36 CHD/DN and 32 chronic hemodialyzed non-diabetic patients with chronic glomerulonephritis (CHD/non-DN) were studied. Plasma H2S was measured with a sulfide sensitive electrode.
  
  
  RESULTS
  Plasma H2S in CHD/DN was significantly lower than that in CHD/non-DN patients. Plasma H2S was positively correlated with plasma TGF-β1, and negatively correlated with MMP-12 in CHD/DN patients. CHD/DN patients exhibited higher CCA-IMT, hsCRP, and lower H2S levels than in CHD/non-DN patients. Moreover, in CHD/DN patients, CCA-IMT was negatively correlated with plasma H2S, and positively correlated with hsCRP and LDL. On multiple regression analysis, H2S levels exhibited independent association with IMT in CHD/DN patients.
  
  
  CONCLUSIONS
  These findings suggest possible linkage between H2S metabolism and TGF-β/Smad signaling pathway modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.
authors.affiliation: Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Nephrology Faculty, Capital Medical University, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Feng
authors.forename: Gui-Zhi
authors.initials: GZ
authors.lastname: Zhang
authors.forename: Shi-Xiang
authors.initials: SX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D003928:Diabetic Nephropathies / Q000097:blood* / Q000150:complications / Q000628:therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D015398:Signal Transduction; D051785:Smad Proteins / Q000502:physiology; D012907:Smoking / Q000009:adverse effects; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000502:physiology; D014511:Uremia / Q000097:blood* / Q000150:complications / Q000628:therapy; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult
chemical_list: D051785:Smad Proteins; D053773:Transforming Growth Factor beta1; D006862:Hydrogen Sulfide