title: Smart polymeric nanoparticles for cancer gene delivery.
abstract: The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.
authors.affiliation: School of Pharmaceutical Science, Shandong University , Jinan 250012, China.
authors.forename: Guimei
authors.initials: G
authors.lastname: Lin
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Leaf
authors.initials: L
authors.lastname: Huang
mesh_terms: D018014:Gene Transfer Techniques; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: cancer therapy; gene delivery; nanoparticle