title: Phenolic and carotenoid profiles and antiproliferative activity of foxtail millet.
abstract: Commonly consumed foxtail millet varieties Jingu28 and Jingu34 were compared in terms of phytochemical composition, antioxidant property, and antiproliferative activity. The cellular antioxidant activity (CAA) was evaluated based on HepG2 cell cultivation. Antiproliferative properties against HepG2 and MDA cell were assayed by methylene blue assay. Total phenolic content (TPC) was 78.79 and 114.22 mg gallic acid equiv/100 g DW in Jingu28 and Jingu34. Both varieties contained ferulic acid, chlorogenic acid, caffeic acid and p-coumaric acid, syringic acid. Xanthophylls and zeaxanthin were also detected. Peroxyl radical scavenging capacity of the foxtail millet were 228.13 (Jingu28) and 355.03 (Jingu34) μmol of vitamin C equiv/100 g, respectively. CAA values of the foxtail millet varieties ranged from 1.52 to 8.97 μmol quercetin equiv/100 g DW. The proliferation of MDA and HepG2 cancer cells were significantly inhibited in a dose-dependent manner after exposure to Jingu28 and Jingu34 extractions.
authors.affiliation: College of Life Science, Shanxi University, Taiyuan 030006, China.
authors.forename: Li Zhen
authors.initials: LZ
authors.lastname: Zhang
authors.affiliation: Department of Food Science, Cornell University, Ithaca, NY 14850-7201, USA. Electronic address: RL23@cornell.edu.
authors.forename: Rui Hai
authors.initials: RH
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D032983:Setaria Plant / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts; D002338:Carotenoids
keywords: Antiproliferation; Caffeic acid (PubChem CID: 689043); Carotenoids; Cellular antioxidant activity; Chlorogenic acid (PubChem CID: 1794427); Ferulic acid (PubChem CID: 445858); Foxtail millet; Phenolic acids; Syringic acid (PubChem CID: 10742); Xanthophyll (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); ρ-Coumaric acid (PubChem CID: 637542)