title: Conspicuity of peripheral zone prostate cancer on computed diffusion-weighted imaging: comparison of cDWI1500, cDWI2000, and cDWI3000.
abstract: OBJECTIVE
  Disadvantages associated with direct high b-value measurements may be avoided with use of computed diffusion-weighted imaging (cDWI). The purpose of this study is to assess the diagnostic performance of cDWI image sets calculated for high b-values of 1500, 2000, and 3000 s/mm(2).
  
  
  METHODS
  Twenty-eight patients who underwent multiparametric MRI of the prostate and radical prostatectomy consecutively were enrolled in this retrospective study. Using a software developed at our institute, cDWI1500, cDWI2000, and cDWI3000 image sets were generated by fitting a monoexponential model. Index lesions on cDWI image sets were scored by two radiologists in consensus considering lesion conspicuity, suppression of background prostate tissue, distortion, image set preferability, and contrast ratio measurements were performed.
  
  
  RESULTS
  Lesion detection rates are the same for computed b-values of 2000 and 3000 s/mm(2) and are better than b-values of 1500 s/mm(2). Best lesion conspicuity and best background prostate tissue suppression are provided by cDWI3000 image set. cDWI2000 image set provides the best zonal anatomical delineation and less distortion and was chosen as the most preferred image set. Average contrast ratio measured on these image sets shows almost a linear relation with the b-values.
  
  
  CONCLUSIONS
  cDWI2000 image set with similar conspicuity and the same lesion detection rate, but better zonal anatomical delineation, and less distortion, was chosen as the preferable image set.
authors.affiliation: Department of Radiology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Vural
authors.affiliation: Department of Biomedical Engineering, Yeditepe University, Atasehir, 34755 Istanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ertaş
authors.affiliation: Department of Radiology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey.
authors.forename: Aslıhan
authors.initials: A
authors.lastname: Onay
authors.affiliation: School of Medicine, Koç University, Topkapı, 34104 Istanbul, Turkey.
authors.forename: Ömer
authors.identifier: 0000-0002-6094-9264
authors.initials: Ö
authors.lastname: Acar
authors.affiliation: School of Medicine, Koç University, Topkapı, 34104 Istanbul, Turkey ; Department of Urology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey.
authors.forename: Tarık
authors.identifier: 0000-0002-1598-7042
authors.initials: T
authors.lastname: Esen
authors.affiliation: Department of Pathology, School of Medicine, Acibadem University, Atasehir, 34752 Istanbul, Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Sağlıcan
authors.affiliation: Department of Biomedical Engineering, Namık Kemal University, Merkez, 59000 Tekirdağ, Turkey.
authors.forename: Hale Pınar
authors.initials: HP
authors.lastname: Zengingönül
authors.affiliation: Department of Radiology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey ; School of Medicine, Koç University, Topkapı, 34104 Istanbul, Turkey.
authors.forename: Sergin
authors.initials: S
authors.lastname: Akpek
mesh_terms: D000368:Aged; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011859:Radiography; D012984:Software
chemical_list: D003287:Contrast Media