title: Insufficient evidence of the effect of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess.
abstract: METHODS
  The Cochrane Oral Health Groups Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase, CINAHL, OpenGrey, ZETOC Conference Proceedings World Health Organization (WHO) International Trials Registry Platform and the US National Institutes of Health Trials Registry databases were searched with no restrictions on the language or date of publication.
  
  
  METHODS
  Randomised controlled trials of systemic antibiotics in adults with a clinical diagnosis of symptomatic apical periodontitis or acute apical abscess, with or without surgical intervention (considered in this situation to be extraction, incision and drainage or endodontic treatment) and with or without analgesics.
  
  
  METHODS
  Study selection, data abstraction and risk of bias assessment were carried out independently by two reviewers.
  
  
  RESULTS
  Two trials involving 62 patients were included. They compared the effects of oral penicillin V potassium versus a matched placebo given in conjunction with a surgical intervention and analgesics to adults with an acute apical abscess or symptomatic necrotic tooth. One study was considered to have a high risk of bias and the other an unclear risk of bias. The primary outcomes were patient-reported pain and swelling. There were no statistically significant differences in participant-reported measures of pain or swelling at any of the time points assessed within the review. The body of evidence was assessed as at very low quality.
  
  
  CONCLUSIONS
  There is very low quality evidence that is insufficient to determine the effects of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess.
authors.affiliation: NYU College of Dentistry, New York, USA.
authors.forename: Analia
authors.initials: A
authors.lastname: Veitz-Keenan
authors.affiliation: NYU College of Dentistry, New York, USA.
authors.forename: Angela M
authors.initials: AM
authors.lastname: De Bartolo
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D010404:Penicillin V / Q000627:therapeutic use*; D010482:Periapical Abscess / Q000188:drug therapy*; D010485:Periapical Periodontitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D010404:Penicillin V