title: Interleukin 8 enhances the immune response of ducks to avian influenza vaccine.
abstract: Interleukins are reported to be valuable immunostimulants in enhancing the immune efficiency of conventional vaccines. In this study, the effect of expression of interleukin 8 (IL-8) on the immune response of ducks to avian influenza vaccine was investigated. The results showed that the serum antibody titer, lymphocyte transformation efficiency and serum interferon gamma (IFN-γ) level of ducks injected with avian influenza vaccine along with a plasmid expressing duck IL-8 were higher than those of ducks injected with conventional immunostimulant Astragalus polysaccharide (APS) or empty plasmid. Therefore, the duck IL-8 may be used as a good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.
authors.forename: Y
authors.initials: Y
authors.lastname: Ruan
authors.forename: X
authors.initials: X
authors.lastname: Ji
authors.forename: M
authors.initials: M
authors.lastname: Wen
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Fu
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D004372:Ducks; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D005585:Influenza in Birds / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D016209:Interleukin-8 / Q000276:immunology*; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D016209:Interleukin-8