title: Risk factors for thrombosis in an african population.
abstract: Little is known about the biological, epidemiological, and clinical risk factors for thrombosis and venous thromboembolism (VTE) among Black Africans. We undertook a study of the prevalence of VTE risk factors for thrombosis in a Senegalese population. A three-year cross-sectional and case-control study involving 105 cases and 200 controls was conducted in various hospitals in Dakar (Senegal). Our results demonstrate that oral contraception, immobilization by casts, surgery, and blood group were significantly associated with VTE occurrence. Additionally, 16 cases and 2 controls had protein S (PS) values of less than 48.4% (M-2SD), exhibiting a highly significant difference (P < 1 × 10(-4)). The number of cases with a low protein C (PC) level was significantly higher than the respective number of controls. Using logistic regression methods, we established a correlation between significantly associated variables and deep venous thrombosis (DVT) occurrence. Age, obesity, sickle cell disease, and PC deficiency were not significantly associated with thrombosis. In contrast, gender, PS deficiency, varicose veins, surgery, non-O blood type, and the presence of antiphospholipid antibodies were significantly and independently associated with DVT. These findings are extremely useful for clinical management of patients suffering from DVT and can help to reduce the high recurrence rate observed in our study.
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Awa Ot
authors.initials: AO
authors.lastname: Fall
authors.affiliation: Laboratory of Hematology, Bicêtre Hospital of Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Proulle
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Abibatou
authors.initials: A
authors.lastname: Sall
authors.affiliation: Cardiology Department, "Grand Yoff" Hospital of Dakar, Senegal.
authors.forename: Alassane
authors.initials: A
authors.lastname: Mbaye
authors.affiliation: Cardiology Department, Dakar Principal Hospital, Senegal.
authors.forename: Pape Samba
authors.initials: PS
authors.lastname: Ba
authors.affiliation: Cardiology Department, Aristide Le Dantec hospital of Dakar, Senegal.
authors.forename: Maboury
authors.initials: M
authors.lastname: Diao
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Moussa
authors.initials: M
authors.lastname: Seck
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Macoura
authors.initials: M
authors.lastname: Gadji
authors.affiliation: Cardiology Department, Dakar Principal Hospital, Senegal.
authors.forename: Sara B
authors.initials: SB
authors.lastname: Gning
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Saliou
authors.initials: S
authors.lastname: Diop
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Tandakha Nd
authors.initials: TN
authors.lastname: Dièye
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Blaise Félix
authors.initials: BF
authors.lastname: Faye
authors.affiliation: Laboratory of Hematology, Cheikh Anta Diop University of Dakar, Senegal.
authors.forename: Doudou
authors.initials: D
authors.lastname: Thiam
authors.affiliation: Laboratory of Hematology, Bicêtre Hospital of Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Dreyfus
keywords: Africa; risk factors; thrombosis