title: Radiogenomics: the search for genetic predictors of radiotherapy response.
abstract: 'Radiogenomics' is the study of genetic variation associated with response to radiotherapy. Radiogenomics aims to uncover the genes and biologic pathways responsible for radiotherapy toxicity that could be targeted with radioprotective agents and; identify genetic markers that can be used in risk prediction models in the clinic. The long-term goal of the field is to develop single nucleotide polymorphism-based risk models that can be used to stratify patients to more precisely tailored radiotherapy protocols. The field has evolved over the last two decades in parallel with advances in genomics, moving from narrowly focused candidate gene studies to large, collaborative genome-wide association studies. Several confirmed genetic variants have been identified and the field is making progress toward clinical translation.
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Kerns
authors.forename: Catharine M L
authors.initials: CM
authors.lastname: West
authors.forename: C Nicolaj
authors.initials: CN
authors.lastname: Andreassen
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Barnett
authors.forename: Søren M
authors.initials: SM
authors.lastname: Bentzen
authors.forename: Neil G
authors.initials: NG
authors.lastname: Burnet
authors.forename: Andre
authors.initials: A
authors.lastname: Dekker
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ruysscher
authors.forename: Alison
authors.initials: A
authors.lastname: Dunning
authors.forename: Matthew
authors.initials: M
authors.lastname: Parliament
authors.forename: Chris
authors.initials: C
authors.lastname: Talbot
authors.forename: Ana
authors.initials: A
authors.lastname: Vega
authors.forename: Barry S
authors.initials: BS
authors.lastname: Rosenstein
mesh_terms: D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D020641:Polymorphism, Single Nucleotide; D011832:Radiation Injuries / Q000235:genetics* / Q000517:prevention & control; D012306:Risk
keywords: genome-wide association study; normal tissue toxicity; radiogenomics; radiotherapy; single nucleotide polymorphisms