title: Endovascular intervention for acute ischemic stroke in light of recent trials.
abstract: Three recently published trials, MR RESCUE, IMS III, and SYNTHESIS Expansion, evaluating the efficacy and safety of endovascular treatment of acute ischemic stroke have generated concerns about the future of endovascular approach. However, the tremendous evolution that imaging and endovascular treatment modalities have undergone over the past several years has raised doubts about the validity of these trials. In this paper, we review the role of endovascular treatment strategies in acute ischemic stroke and discuss the limitations and shortcomings that prevent generalization of the findings of recent trials. We also provide our experience in endovascular treatment of acute ischemic stroke.
authors.affiliation: Department of Surgery, University of Arizona, Tucson, AZ Department of Surgery, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Kenan
authors.initials: K
authors.lastname: Alkhalili
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA.
authors.forename: Nohra
authors.identifier: 0000-0002-2422-4346
authors.initials: N
authors.lastname: Chalouhi
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA.
authors.forename: Stavropoula
authors.initials: S
authors.lastname: Tjoumakaris
authors.affiliation: Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: David
authors.initials: D
authors.lastname: Hasan
authors.affiliation: Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Starke
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA.
authors.forename: Mario
authors.identifier: 0000-0002-6605-690X
authors.initials: M
authors.lastname: Zanaty
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Rosenwasser
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA ; Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: Jabbour
mesh_terms: D002545:Brain Ischemia / Q000628:therapy*; D002986:Clinical Trials as Topic; D057510:Endovascular Procedures; D006801:Humans; D015607:Stents; D020521:Stroke / Q000628:therapy*