title: [Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality].
abstract: Calcium ion (Ca2+) is the only second messenger well recognized for the established biological role among various inorganic ions. When cellular Ca2+ controls diverse biological phenomena, it is regulated under exquisitely precise mechanisms. Many proteins have been identified as Ca2+ signal-regulating factors, and still new "players" are added to the repertory. In this review, we will focus on Ca2+ channels, Ca2+-binding proteins,and signaling pathways controlled by these Ca2+ signal-regulating proteins, in order to discuss on molecular bases, biological significance, and possible future developments of Ca2+ signaling.
authors.affiliation: Laboratory of Environmental Systems Biology, Graduate School of Environmental Studies and Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering Kyoto University, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Mori
authors.forename: Masayuki X
authors.initials: MX
authors.lastname: Mori
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nishida
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002136:Calcium, Dietary / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D002136:Calcium, Dietary; D002118:Calcium