title: Marine natural products that interfere with multiple cytoskeletal protein interactions.
abstract: Various marine natural products that target cytoskeletal proteins have been discovered. A few of these compounds have recently been shown to induce or inhibit protein-protein interactions. Lobophorolide, an actin filament-disrupting macrolide, binds to actin with a unique 2 : 2 stoichiometry in which two lobophorolide molecules cooperate to stabilize an actin dimer. Adociasulfates, merotriterpenoid derivatives, inhibit microtubule-stimulated ATPase activity of a motor protein kinesin by blocking both the binding of microtubules and the processive motion of kinesin along microtubules. The antitumor macrolide aplyronine A synergistically binds to tubulin in association with actin, and prevents spindle formation and mitosis. In this highlight, we address recent chemical biology studies on these mechanistically-attractive marine natural products. These findings may be useful for the design and development of new pharmacological tools and therapeutic agents.
authors.affiliation: Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan. mkita@chem.tsukuba.ac.jp kigoshi@chem.tsukuba.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kita
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D000199:Actins / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D016547:Kinesins / Q000187:drug effects; D018942:Macrolides / Q000494:pharmacology; D008386:Marine Biology; D008870:Microtubules / Q000187:drug effects*; D015394:Molecular Structure; D011714:Pyrans / Q000494:pharmacology; D014404:Tubulin / Q000378:metabolism
chemical_list: D000199:Actins; D001688:Biological Products; D018942:Macrolides; D011714:Pyrans; D014404:Tubulin; C475660:lobophorolide; C104057:aplyronine A; D016547:Kinesins