title: Synthesis of indazole motifs and their medicinal importance: an overview.
abstract: Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.
authors.affiliation: Dept. of Chemistry, Govt. College of Arts & Science, Aurangabad 431001, India. Electronic address: gaikwad_dd@yahoo.com.
authors.forename: Digambar D
authors.initials: DD
authors.lastname: Gaikwad
authors.affiliation: Dept. of Chemistry, Govt. College of Arts & Science, Aurangabad 431001, India.
authors.forename: Archana D
authors.initials: AD
authors.lastname: Chapolikar
authors.affiliation: Dept. of Chemistry, Govt. College of Arts & Science, Aurangabad 431001, India.
authors.forename: Chandrashekhar G
authors.initials: CG
authors.lastname: Devkate
authors.affiliation: Dept. of Chemistry, Govt. College of Arts & Science, Aurangabad 431001, India.
authors.forename: Khandu D
authors.initials: KD
authors.lastname: Warad
authors.affiliation: Dept. of Chemistry, Govt. College of Arts & Science, Aurangabad 431001, India.
authors.forename: Amit P
authors.initials: AP
authors.lastname: Tayade
authors.affiliation: Dept. of Chemistry, Deogiri College, Aurangabad 431001, India.
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Pawar
authors.affiliation: School of Pharmacy, Department of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D059350:Chronic Pain / Q000188:drug therapy; D006801:Humans; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009294:Narcotics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014150:Antipsychotic Agents; D007191:Indazoles; D009294:Narcotics
keywords: Antipsychotic; Antiretroviral; Antitumor; Axitinib; Chronic pain; Narcotic