title: Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls.
abstract: BACKGROUND
  Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test.
  
  
  OBJECTIVE
  To determine the best predictive model for detecting puberty in girls.
  
  
  METHODS
  Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15).
  
  
  METHODS
  Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed.
  
  
  RESULTS
  The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%.
  
  
  CONCLUSIONS
  The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.
authors.forename: Vivian L
authors.initials: VL
authors.lastname: Chin
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cai
authors.forename: Leslie
authors.initials: L
authors.lastname: Lam
authors.forename: Bina
authors.initials: B
authors.lastname: Shah
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D002648:Child; D002675:Child, Preschool; D003940:Diagnostic Techniques, Endocrine / Q000592:standards; D005260:Female; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D011627:Puberty; D011629:Puberty, Precocious / Q000097:blood* / Q000175:diagnosis; D012016:Reference Values; D012189:Retrospective Studies; D013268:Stimulation, Chemical
chemical_list: D006062:Gonadotropins