title: Cortical morphology and early adverse birth events in men with first-episode psychosis.
abstract: BACKGROUND
  Reduced cortical gray-matter volume is commonly observed in patients with psychosis. Cortical volume is a composite measure that includes surface area, thickness and gyrification. These three indices show distinct maturational patterns and may be differentially affected by early adverse events. The study goal was to determine the impact of two distinct obstetrical complications (OCs) on cortical morphology.
  
  
  METHODS
  A detailed birth history and MRI scans were obtained for 36 patients with first-episode psychosis and 16 healthy volunteers.
  
  
  RESULTS
  Perinatal hypoxia and slow fetal growth were associated with cortical volume (Cohen's d = 0.76 and d = 0.89, respectively) in patients. However, the pattern of associations differed across the three components of cortical volume. Both hypoxia and fetal growth were associated with cortical surface area (d = 0.88 and d = 0.72, respectively), neither of these two OCs was related to cortical thickness, and hypoxia but not fetal growth was associated with gyrification (d = 0.85). No significant associations were found within the control sample.
  
  
  CONCLUSIONS
  Cortical dysmorphology was associated with OCs. The use of a global measure of cortical morphology or a global measure of OCs obscured important relationships between these measures. Gyrification is complete before 2 years and its strong relationship with hypoxia suggests an early disruption to brain development. Cortical thickness matures later and, consistent with previous research, we found no association between thickness and OCs. Finally, cortical surface area is largely complete by puberty and the present results suggest that events during childhood do not fully compensate for the effects of early disruptive events.
authors.affiliation: Department of Psychiatry,University of British Columbia,Vancouver,Canada.
authors.forename: G N
authors.initials: GN
authors.lastname: Smith
authors.affiliation: Department of Psychology,Simon Fraser University,Burnaby,Canada.
authors.forename: A E
authors.initials: AE
authors.lastname: Thornton
authors.affiliation: Department of Radiology,University of British Columbia,Vancouver,Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Lang
authors.affiliation: Department of Psychiatry,University of British Columbia,Vancouver,Canada.
authors.forename: G W
authors.initials: GW
authors.lastname: MacEwan
authors.affiliation: Department of Psychiatry,University of British Columbia,Vancouver,Canada.
authors.forename: L C
authors.initials: LC
authors.lastname: Kopala
authors.affiliation: Department of Psychiatry,University of British Columbia,Vancouver,Canada.
authors.forename: W
authors.initials: W
authors.lastname: Su
authors.affiliation: Department of Psychiatry,University of British Columbia,Vancouver,Canada.
authors.forename: W G
authors.initials: WG
authors.lastname: Honer
mesh_terms: D000293:Adolescent; D000328:Adult; D001720:Birth Injuries / Q000453:epidemiology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D011618:Psychotic Disorders / Q000453:epidemiology / Q000473:pathology*; D012307:Risk Factors; D055815:Young Adult
keywords: Birthweight; cortical gray matter; imaging; obstetric complications; perinatal hypoxia; psychosis