title: The study of psychiatric disease genes and drugs in zebrafish.
abstract: Mutations associated with psychiatric disease are being identified, but it remains unclear how the affected genes contribute to disease. Zebrafish is an emerging model to study psychiatric disease genes with a rich repertoire of phenotyping tools. Recent zebrafish research has uncovered potential developmental phenotypes for genes associated with psychiatric disorders, while drug screens have behaviorally characterized small molecules and identified new classes of drugs. Behavioral studies have led to promising models for endophenotypes of psychiatric diseases. While further research is needed to firmly link these models to psychiatric disorders, they are valuable tools for phenotyping genetic mutations and drugs. Recently developed tools in genome editing and in vivo imaging promise additional insights into the processes disrupted by mutations in psychiatric disease genes.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Room 1027, Cambridge, MA 02138, United States. Electronic address: haesemeyer@fas.harvard.edu.
authors.forename: Martin
authors.initials: M
authors.lastname: Haesemeyer
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Room 1027, Cambridge, MA 02138, United States; Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States; Center for Brain Science, Harvard University, Cambridge, MA 02138, United States; Harvard Stem Cell Institute, Cambridge, MA 02138, United States; FAS Center for Systems Biology, Harvard University, MA 02138, United States. Electronic address: schier@fas.harvard.edu.
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Schier
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D058068:Endophenotypes; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D015027:Zebrafish
chemical_list: D014150:Antipsychotic Agents