title: Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet.
abstract: BACKGROUND
  A sedentary lifestyle and high-fat feeding are risk factors for cardiometabolic disorders. This study determined whether moderate exercise training prevents the cardiometabolic changes induced by a high-fat diet (HFD).
  
  
  METHODS
  Sixty-day-old rats were subjected to moderate exercise three times a week for 30 days. After that, trained rats received a HFD (EXE-HFD) or a commercial normal diet (EXE-NFD) for 30 more days. Sedentary animals also received the diets (SED-HFD and SED-NFD). Food intake and body weight were measured weekly. After 120 days of life, analyses were performed. Data were analysed with two-way ANOVA and the Tukey post-test.
  
  
  RESULTS
  Body weight gain induced by HFD was attenuated in trained animals. HFD reduced food intake by approximately 30% and increased body fat stores by approximately 75%. Exercise attenuated 80% of the increase in fat pads and increased 24% of soleus muscle mass in NFD animals. HFD induced a hyper-response to glucose injection, and exercise attenuated this response by 50%. Blood pressure was increased by HFD, and the beneficial effect of exercise in reducing blood pressure was inhibited by HFD. HFD increased vagal activity by 65% in SED-HFD compared with SED-NFD rats, and exercise blocked this increase. HFD reduced sympathetic activity and inhibited the beneficial effect of exercise on ameliorating sympathetic activity.
  
  
  CONCLUSIONS
  Four weeks of moderate exercise at low frequency was able to prevent the metabolic changes induced by a HFD but not the deleterious effects of diet on the cardiovascular system.
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Laize Peron
authors.initials: LP
authors.lastname: Tófolo
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Tatiane Aparecida
authors.initials: TA
authors.lastname: da Silva Ribeiro
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Ananda
authors.initials: A
authors.lastname: Malta
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Rosiane Aparecida
authors.initials: RA
authors.lastname: Miranda
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Rodrigo Mello
authors.initials: RM
authors.lastname: Gomes
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Júlio Cezar
authors.initials: JC
authors.lastname: de Oliveira
authors.affiliation: UPSP-EGEAL Institut Polytechnique LaSalle de Beauvais, 6000, Beauvais, France.
authors.forename: Latifa
authors.initials: L
authors.lastname: Abdennebi-Najar
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Douglas Lopes
authors.initials: DL
authors.lastname: de Almeida
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Amanda Bianchi
authors.initials: AB
authors.lastname: Trombini
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Claudinéia Conationi
authors.initials: CC
authors.lastname: da Silva Franco
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Audrei
authors.initials: A
authors.lastname: Pavanello
authors.affiliation: UPSP-EGEAL Institut Polytechnique LaSalle de Beauvais, 6000, Beauvais, France.|CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, 70040-020, Brazil.
authors.forename: Gabriel Sergio
authors.initials: GS
authors.lastname: Fabricio
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Wilson
authors.initials: W
authors.lastname: Rinaldi
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Luiz Felipe
authors.initials: LF
authors.lastname: Barella
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil. pmathias@uem.br.
authors.forename: Paulo Cezar
authors.initials: PC
authors.lastname: de Freitas Mathias
authors.affiliation: Laboratory of Secretion Cell Biology - Block H67, Room 19, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Colombo Avenue 5970, Maringá, PR, 87020-900, Brazil.
authors.forename: Kesia
authors.initials: K
authors.lastname: Palma-Rigo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition; D001835:Body Weight; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D008659:Metabolic Diseases / Q000517:prevention & control*; D024821:Metabolic Syndrome / Q000517:prevention & control; D018482:Muscle, Skeletal / Q000502:physiology; D009765:Obesity / Q000517:prevention & control; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D057185:Sedentary Behavior; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin
keywords: Autonomic nervous system; Cardiometabolic syndrome; Exercise; High-fat diet; Obesity