title: An imagable and photothermal "Abraxane-like" nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors.
abstract: A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-of-concept study.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000068196:Albumin-Bound Paclitaxel; D000418:Albumins / Q000737:chemistry / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D017239:Paclitaxel / Q000737:chemistry / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*; D011487:Protein Conformation; D040521:Subcutaneous Tissue / Q000473:pathology*
chemical_list: D000068196:Albumin-Bound Paclitaxel; D000418:Albumins; D007208:Indocyanine Green; D017239:Paclitaxel
keywords: combination therapy; human serum albumin; indocyanine green; lung metastasis; paclitaxel