title: SnapShot: GPCR-Ligand Interactions.
abstract: G-protein-coupled receptors enable cells to recognize numerous external stimuli and to transmit corresponding signals across the plasma membrane to trigger appropriate cellular responses. Crystal structures of a number of these receptors have now been determined in inactive and active conformations bound to chemically and functionally distinct ligands. These crystal structures illustrate overall receptor organization and atomic details of ligand-receptor interactions.
authors.affiliation: Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, 208016, India.
authors.forename: Eshan
authors.initials: E
authors.lastname: Ghosh
authors.affiliation: Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, 208016, India.
authors.forename: Kumari
authors.initials: K
authors.lastname: Nidhi
authors.affiliation: Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, 208016, India.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Shukla
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled