title: [Distribution change of mast cells in human nasal polyps].
abstract: OBJECTIVE
  To investigate the distribution of mast cells in nasal polyps.
  
  
  METHODS
  Biopsy specimens from patients with nasal polyps (n = 20) and control patients (n = 8) were obtained and included in this study. The distribution of mast cells in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8, IL-6) in the epithelial cells of normal nasal mucosa and nasal polyps was determined by immunohistochemistry.
  
  
  RESULTS
  Mast cells migrate to intraepithelial in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8) was up regulated in the epithelial cells of nasal polyps compare to normal nasal mucosa.
  
  
  CONCLUSIONS
  Our findings showed that mast cells migrate to intraepithelial in nasal polyps and the over expression of chemotaxins (CCL5, CCL11, CX3CL1, IL-8) may be response for mast cells' migration in nasal polyps. Mast cells might be associated with the development of nasal polyps.
authors.forename: Guimin
authors.initials: G
authors.lastname: Zhang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Shi
authors.forename: Peiyong
authors.initials: P
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
mesh_terms: D054413:Chemokine CCL11 / Q000378:metabolism; D018946:Chemokine CCL5 / Q000378:metabolism; D054428:Chemokine CX3CL1 / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D009297:Nasal Mucosa / Q000166:cytology* / Q000378:metabolism; D009298:Nasal Polyps / Q000378:metabolism / Q000473:pathology*; D015854:Up-Regulation
chemical_list: C483024:CCL5 protein, human; C515538:CX3CL1 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D054428:Chemokine CX3CL1; D015850:Interleukin-6; D016209:Interleukin-8