title: Antiproliferative activity of synthetic fatty acid amides from renewable resources.
abstract: In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Daiane S
authors.initials: DS
authors.lastname: dos Santos
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Luciana A
authors.initials: LA
authors.lastname: Piovesan
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Caroline R Montes
authors.initials: CR
authors.lastname: D'Oca
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Carolina R Lopes
authors.initials: CR
authors.lastname: Hack
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Tamara G M
authors.initials: TG
authors.lastname: Treptow
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Marieli O
authors.initials: MO
authors.lastname: Rodrigues
authors.affiliation: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Unicamp, Campinas, SP, Brazil.
authors.forename: Débora B
authors.initials: DB
authors.lastname: Vendramini-Costa
authors.affiliation: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Unicamp, Campinas, SP, Brazil.
authors.forename: Ana Lucia T G
authors.initials: AL
authors.lastname: Ruiz
authors.affiliation: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Unicamp, Campinas, SP, Brazil.
authors.forename: João Ernesto
authors.initials: JE
authors.lastname: de Carvalho
authors.affiliation: Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. Electronic address: dqmdoca@furg.br.
authors.forename: Marcelo G Montes
authors.initials: MG
authors.lastname: D'Oca
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D012277:Ricinoleic Acids / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D005227:Fatty Acids; D012277:Ricinoleic Acids; C030521:ricinoleic acid
keywords: Glioma; Multidrug resistance; Ovarian cancer; Ricinoleic acid