title: Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo.
abstract: Head and neck cancer (HNC) is one of the most common forms of cancer in Taiwan. In addition, head and neck cancer cells (HNCs) are highly tumorigenic and resistant to conventional therapy. Therefore, development of new therapeutic regimens that are adjuvant to conventional treatments would benefit future head and neck cancer therapy. In this study, we found that the lyophilized particles and ethanolic extracts ofAntrodia cinnamomeamycelia inhibited the tumor growth of HNCs by xenograft assayin vivo. Moreover, administration of lyophilized particles or ethanolic extracts to nude mice did not cause significant side effects. Our study revealed that theAntrodia cinnamomeamycelia extract (ACME) efficiently inhibited the tumorigenicity of HNCs without causing organ failure. Furthermore, it showed that ACME may work as a novel drug candidate for alternative treatments for head and neck cancer.
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, 112 Taipei, Taiwan.
authors.forename: Ching-Wen
authors.initials: CW
authors.lastname: Chang
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, 112 Taipei, Taiwan.
authors.forename: Yu-Syuan
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Department of Biotechnology, Hungkuang University, 433 Taichung, Taiwan.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Grape King Inc, 320 Taoyuan County, Taiwan.
authors.forename: Chin-Chu
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Grape King Inc, 320 Taoyuan County, Taiwan.
authors.forename: Sen-Je
authors.initials: SJ
authors.lastname: Sheu
authors.affiliation: Grape King Inc, 320 Taoyuan County, Taiwan.
authors.forename: Ting-Wei
authors.initials: TW
authors.lastname: Lin
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, 115 Taipei, Taiwan.
authors.forename: Te-Chang
authors.initials: TC
authors.lastname: Lee
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, 112 Taipei, Taiwan ; Graduate Institute of Chinese Medical Science and Institute of Medical Science, China Medical University, 404 Taichung, Taiwan ; Genome Research Center, National Yang-Ming University, 112 Taipei, Taiwan ; Department of Dentistry, Taipei Veterans General Hospital, 112 Taipei, Taiwan.
authors.forename: Jeng-Fan
authors.initials: JF
authors.lastname: Lo
keywords: Antrodia cinnamomea;; Head and neck cancer