title: Novel membrane-based targets - Therapeutic potential in gynecological cancers.
abstract: Recent advances have been made in the molecular profiling of gynecological tumors. These discoveries have led to the development of targeted therapies that have the potential to disrupt molecular pathways involved in the oncogenesis or tumor progression. In this review, we highlight areas of recent progress in the field of membrane receptor inhibitors in gynecological malignancies and describe the biological rationale underlying the inhibition of these receptors. We will introduce drug immuno-conjugates, and give an update on the biological rationale and the clinical studies involving agents directed against EGFR, HER3, IGFR, MET, FGFR, NOTCH, and TRAIL. We also discuss the challenge facing these new therapies.
authors.affiliation: Department of Medicine, Gustave Roussy, University of ParisSud, Villejuif, France; Medical Oncology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Electronic address: marco.gizzi@ghdc.be.
authors.forename: M
authors.initials: M
authors.lastname: Gizzi
authors.affiliation: Department of Medicine, Gustave Roussy, University of ParisSud, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Pautier
authors.affiliation: Department of Medicine, Gustave Roussy, University of ParisSud, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Lhomme
authors.affiliation: Department of Medicine, Gustave Roussy, University of ParisSud, Villejuif, France. Electronic address: alexandra.leary@gustaveroussy.fr.
authors.forename: A
authors.initials: A
authors.lastname: Leary
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D018796:Immunoconjugates / Q000494:pharmacology / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D018796:Immunoconjugates; D011956:Receptors, Cell Surface
keywords: Gynecological malignancies; Membrane receptor inhibitors; Targeted therapies