title: Classical Hodgkin lymphoma occurring in association with progressive transformation of germinal center.
abstract: Progressive transformation of germinal center (PTGC) represents an asymptomatic persistent form of lymphadenopathy. We present a case of classical Hodgkin lymphoma occurring in association with PTGC. The patient was a 60-year-old woman who had noted swelling of the submandibular lymph nodes. Histopathologically, the enlarged lymph nodes appeared as multiple nodules with ill-defined and irregularly expanded germinal centers. Immunohistochemical studies indicated that the germinal center cells comprised B cells that were positive for CD10 and CD20, and negative for bcl-2. Enlarged vascular endothelial cells were present in the interfollicular areas. CD30-positive Hodgkin & Reed-Sternberg cells were seen between the interfollicular area and the mantle zone, and were surrounded by CD3-positive T-cells. In situ hybridization studies demonstrated no expression of Epstein-Barr virus-encoded small RNA in the Hodgkin & Reed-Sternberg cells. A diagnosis of classical Hodgkin lymphoma complicated by PTGC was made from the lymph node specimen.
authors.affiliation: Department of Pathology, School of Medicine, Iwate Medical University.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yashima-Abo
authors.forename: Takashi
authors.initials: T
authors.lastname: Satoh
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimosegawa
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ishida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Masuda
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D018858:Germinal Center / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008875:Middle Aged