title: [Extra-oral signs to look for in patients exhibiting oral warning signs of genetic diseases].
abstract: This article is aimed at defining guidelines for dental surgeons to manage patients with warning signs of rare genetic diseases. Anomalies of tooth development may occur as an isolated condition or in association with other symptoms in syndromes. In many cases, dental anomalies may be the first manifestations of a genetic disease. The dentist can contribute to the diagnosis, and hence to an early treatment of this syndrome. When one or more dental anomalies are found, practitioners should refer patients to a genetic clinic or a specialized reference center to diagnose genetic diseases. Therefore, we provide, for the first time, a table of extra-oral signs that dental surgeons can look for in patients exhibiting heritable dental developmental anomalies.
authors.affiliation: Département d'odontologie pédiatrique, faculté de chirurgie dentaire de Nantes, 44042 Nantes cedex 01, France; Service d'odontologie conservatrice et pédiatrique, CHU de Nantes, 44000 Nantes, France; Inserm UMRS 1064, Centre de recherche en transplantation et en immunologie, 44093 Nantes cedex 01, France. Electronic address: brigitte.alliot-licht@univ-nantes.fr.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Alliot-Licht
authors.affiliation: Département d'odontologie pédiatrique, faculté de chirurgie dentaire de Nantes, 44042 Nantes cedex 01, France.
authors.forename: Charlène
authors.initials: C
authors.lastname: Lusson
authors.affiliation: Service d'odontologie conservatrice et pédiatrique, CHU de Nantes, 44000 Nantes, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hyon
authors.affiliation: Département d'odontologie pédiatrique, faculté de chirurgie dentaire de Nantes, 44042 Nantes cedex 01, France; Service d'odontologie conservatrice et pédiatrique, CHU de Nantes, 44000 Nantes, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dajean-Trutaud
authors.affiliation: Service de génétique médicale, CHU de Nantes, 44000 Nantes, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Le Caignec
authors.affiliation: Département d'odontologie pédiatrique, faculté de chirurgie dentaire de Nantes, 44042 Nantes cedex 01, France; Service d'odontologie conservatrice et pédiatrique, CHU de Nantes, 44000 Nantes, France.
authors.forename: Serena
authors.initials: S
authors.lastname: Lopez-Cazaux
mesh_terms: D000013:Congenital Abnormalities / Q000175:diagnosis; D003815:Dentists / Q000458:organization & administration; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D006801:Humans; D009056:Mouth Abnormalities / Q000175:diagnosis; D017410:Practice Guidelines as Topic; D014071:Tooth Abnormalities / Q000175:diagnosis* / Q000209:etiology
keywords: Anomalies buccales; Diagnosis; Diagnostic; Maladie rare; Oral anomalies; Rare disease; Syndrome