title: Association between DLK1 and IGF-I gene expression and meat quality in sheep.
abstract: The aim of the present study was to detect delta-like 1 ho-molog (DLK1) and insulin-like growth factor-I (IGF-I) gene expression in the longissimus dorsi of Hu sheep at different growth stages and study the association between these genes and meat quality. The diameter and density of muscle fibers and tenderness of the longissimus dorsi were measured. Growth stage, but not sex, significantly affected DLK1 and IGF-I expression. DLK1 and IGF-I expression in the sheep longissimus dorsi gradually increased with growth, but also decreased during some periods. These results suggest that different growth stages significantly affect DLK1 and IGF-I gene expression in sheep muscle tissue. The ex-pression of DLK1 and IGF-I genes were positively and significantly (P < 0.01) correlated with muscle fiber diameter and muscle fiber shear stress, and negatively and significantly (P < 0.01) correlated with muscle fiber density. Muscle fiber diameter was positively and significantly (P < 0.01) correlated with muscle fiber shear stress, and negatively and significantly (P < 0.01) correlated with muscle fiber density. In addition, DLK-1 expression was significantly (P < 0.01) and positively correlated with IGF-I expression.
authors.affiliation: Animal Science and Technology College, Yangzhou University, Yangzhou, China dkxmsunwei@163.com.
authors.forename: R
authors.initials: R
authors.lastname: Su
authors.affiliation: Animal Science and Technology College, Yangzhou University, Yangzhou, China.
authors.forename: W
authors.initials: W
authors.lastname: Sun
authors.affiliation: Animal Science and Technology College, Yangzhou University, Yangzhou, China.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.affiliation: Animal Science and Technology College, Yangzhou University, Yangzhou, China.
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Wang
authors.affiliation: Animal Science and Technology College, Yangzhou University, Yangzhou, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Lv
authors.affiliation: Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
authors.forename: H H
authors.initials: HH
authors.lastname: Musa
authors.affiliation: Animal Science & Veterinary Medicine Bureau of Suzhou City, Suzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.affiliation: Animal Science & Veterinary Medicine Bureau of Suzhou City, Suzhou, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Animal Science & Veterinary Medicine Bureau of Suzhou City, Suzhou, China.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Wu
mesh_terms: D000818:Animals; D015870:Gene Expression; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D008460:Meat; D008565:Membrane Proteins / Q000096:biosynthesis*; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D034561:Sheep, Domestic / Q000235:genetics* / Q000254:growth & development
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D007334:Insulin-Like Growth Factor I