title: Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: steps toward their clinical evaluation.
abstract: Although the antiretroviral therapy has led to a long-term control of HIV-1, it does not cure the disease. Therefore, several strategies are being explored to develop an effective HIV vaccine, such as the use of dendritic cells (DCs). DC-based immunotherapies bear different limitations, but one of the most critical point is the antigen loading into DCs. Nanotechnology offers new tools to overcome these constraints. Dendrimers have been proposed as carriers for targeted delivery of HIV antigens in DCs. These nanosystems can release the antigens in a controlled manner leading to a more potent specific immune response. This review focuses on the first steps for clinical development of dendrimers to assess their safety and potential use in DC-based immunotherapies against HIV.
authors.affiliation: Laboratorio InmunoBiología Molecular, Sección Inmunologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria del Gregorio Marañón, C/Dr. Esquerdo 46, 28007, Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Vacas-Córdoba
authors.forename: Núria
authors.initials: N
authors.lastname: Climent
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: De La Mata
authors.forename: Montserrat
authors.initials: M
authors.lastname: Plana
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
authors.forename: Marjorie
authors.initials: M
authors.lastname: Pion
authors.forename: Felipe
authors.initials: F
authors.lastname: García
authors.forename: Maria Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology / Q000627:therapeutic use*; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D050091:Dendrimers / Q000737:chemistry / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000276:immunology; D005822:Genetic Vectors; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007167:Immunotherapy
chemical_list: D016915:AIDS Vaccines; D050091:Dendrimers
keywords: HIV; dendrimer; dendritic cell; immunotherapy; nanomedicine; vaccine