title: Synthesis and characterization of antibacterial carboxymethyl cellulose/ZnO nanocomposite hydrogels.
abstract: In this study, carboxymethyl cellulose/ZnO nanocomposite hydrogels have been synthesized through the in situ formation of ZnO nanoparticles within swollen carboxymethyl cellulose hydrogels. The formation of ZnO nanoparticles in the hydrogels was confirmed using X-ray diffraction, UV-vis spectroscopy and scanning electron microscopy (SEM) studies. SEM micrographs revealed the formation of ZnO nanoparticles with size range of 10-20 nm within the hydrogel matrix. The prepared nanocomposite hydrogels showed a pH and salt sensitive swelling behavior. The ZnO nanocomposite hydrogels have rather higher swelling in different aqueous solutions in comparison with neat hydrogel. The nanocomposite hydrogels demonstrated antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria. The developed carboxymethyl cellulose/ZnO nanocomposite hydrogels can be used effectively for biomedical application.
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Gholamali
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
authors.affiliation: Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aghazadeh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D002266:Carboxymethylcellulose Sodium; D015034:Zinc Oxide
keywords: Antibacterial; Carboxymethylcellulose; Hydrogel; Nanocomposite; Zinc oxide nanopartice