title: Genetic association analysis using weighted false discovery rate approach on Genetic Analysis Workshop 18 data.
abstract: In a genome-wide association study, association between disease trait and hundreds of thousands of genetic markers are tested. Several methods have been proposed to control the false discovery rate in such high-throughput data to adjust for multiple hypotheses testing. For Genetic Analysis Workshop 18, we applied the method of false discovery rate control with p value weighting on family-based association tests on quantitative trait to detect association between single-nucleotide polymorphisms (SNPs) and mean arterial pressure. This method can improve statistical power by incorporating independent but relevant information about the research objective. Using the real genetic and phenotype data of chromosome 3 from Genetic Analysis Workshop 18, 1 SNP from gene CACNA2D3 was found to have significant association with mean arterial pressure.
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Xin
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Espin-Garcia
authors.affiliation: Ontario Cancer Institute, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Abul Kalam
authors.initials: AK
authors.lastname: Azad
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada ; Ontario Cancer Institute, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada ; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, M5T 3M7, Canada.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada ; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, M5T 3M7, Canada.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu