title: CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveillance.
abstract: The mechanisms through which tumor antigen-specific T cells are elicited in natural or chemotherapy-induced immunosurveillance have been elusive. In this issue of Cancer Cell, two papers by Broz and colleagues and Ruffell and colleagues delineate an important role for a specific dendritic cell subset characterized by CD103 expression, dependence on transcription factors Batf3 and Irf8, and interleukin-12 production.
authors.affiliation: Gustave Roussy Cancer Campus, 94805 Villejuif, France; INSERM U1015, 94805 Villejuif, France; Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, 91400 Orsay, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, 94805 Villejuif, France. Electronic address: laurence.zitvogel@gustaveroussy.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.affiliation: Gustave Roussy Cancer Campus, 94805 Villejuif, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, 94805 Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75006 Paris, France. Electronic address: kroemer@orange.fr.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000502:physiology*; D053765:Interleukin-12 Subunit p35 / Q000096:biosynthesis*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D017239:Paclitaxel / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C556062:IL10 protein, mouse; C508858:IL12A protein, human; D053765:Interleukin-12 Subunit p35; D016753:Interleukin-10; D017239:Paclitaxel