title: Functional vesicles formed by anticancer drug assembly.
abstract: In this Letter, a new type of nitrogen mustard conjugate vesicles is developed to improve the stability and efficiency of anticancer drug. Benzoic acid nitrogen mustard-peptide (AAAK) conjugate was designed and synthesized, which was found to self-assemble into vesicles in water. The formation of the vesicles was confirmed by dynamic light scattering (DLS), transmission electron microscopy (TEM) and circular dichroism (CD). The degradation data revealed that the benzoic acid nitrogen mustard peptide (AAAK) conjugate vesicles are more stable than the parent drug in aqueous solution. Furthermore, MTT assay revealed that the free drug conjugate has similar antitumor activity against MCF-7, Hela, HepG-2 cell lines compared with the parent drug. The benzoic acid nitrogen mustard-peptide conjugate vesicles may have potential in the treatment of cancers.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Fang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China.
authors.forename: Yemin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China. Electronic address: lixs@seu.edu.cn.
authors.forename: Xinsong
authors.initials: X
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019817:Benzoic Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D008466:Mechlorethamine / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008466:Mechlorethamine; D019817:Benzoic Acid
keywords: Antitumor activity; Conjugate; Nitrogen mustards; Peptide; Self-assembly