title: An extraordinary case of mesenchymal chondrosarcoma metastasis in the thyroid.
abstract: Secondary tumours of the thyroid gland account for 1.25 to 3 % in clinical series and reach 24 % in autopsy series. Chondrosarcoma is a rare malignant mesenchymal tumour of chondrogenic nature; the mesenchymal variant represents less than 3 % of all chondrosarcomas, being therefore extremely rare. A mesenchymal chondrosarcoma metastasis in the thyroid is exceptional; to our knowledge, only three previous cases of chondrosarcoma metastasis in the thyroid have been reported to date but none of such cases corresponded to a mesenchymal chondrosarcoma. We present the first of such a case in a 27-year-old woman with a 4-year history of mesenchymal chondrosarcoma of the sacrum that was treated by surgery and chemotherapy. At the present admission, head and neck computed tomography revealed a well-defined nodule in the thyroid gland. The diagnosis of metastasis from the mesenchymal chondrosarcoma was made in the right lobectomy specimen.
authors.affiliation: Centro Hospitalar Lisboa Norte, EPE-Hospital de Santa Maria, Lisbon, Portugal, santi.orfer@gmail.com.
authors.forename: Santiago
authors.initials: S
authors.lastname: Ortiz
authors.forename: Francisco
authors.initials: F
authors.lastname: Tortosa
authors.forename: Manuel
authors.initials: M
authors.lastname: Sobrinho Simões
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002356:Cartilage / Q000473:pathology; D018211:Chondrosarcoma, Mesenchymal / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D012447:Sacrum; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000556:secondary*; D013965:Thyroidectomy
chemical_list: D000970:Antineoplastic Agents