title: Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats.
abstract: This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahiskalioglu
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ince
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
authors.affiliation: Department of Anaesthesiology And Reanimation, Regional Education And Research Hospital, 25100, Erzurum, Turkey.
authors.forename: Elif Oral
authors.initials: EO
authors.lastname: Ahiskalioglu
authors.affiliation: Department of Anaesthesiology And Reanimation, Regional Education And Research Hospital, 25100, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Comez
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Dostbil
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Celik
authors.affiliation: Department of Biochemistry, Faculty of Medicine, 100, Yil University, 65000, Van, Turkey.
authors.forename: Hamit Hakan
authors.initials: HH
authors.lastname: Alp
authors.affiliation: Department of Cardiology, Bayburt State Hospital, 69000, Bayburt, Turkey.
authors.forename: Resit
authors.initials: R
authors.lastname: Coskun
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Ataturk University, 25100, Erzurum, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Taghizadehghalehjoughi
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdogan University, 53000, Rize, Turkey. bahadirsuleyman@yandex.com.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Suleyman
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D019610:Cytoprotection; D004249:DNA Damage / Q000187:drug effects; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006331:Heart Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D007649:Ketamine; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D017208:Rats, Wistar; D013997:Time Factors; D019805:alpha-Methyltyrosine / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D019805:alpha-Methyltyrosine; D007649:Ketamine; D008790:Metoprolol
keywords: Antioxidant; Cardiotoxicity; Ketamine; Metoprolol; Metyrosine; Oxidant; Rat