title: Towards the genetic control of insect vectors: An overview.
abstract: Insects are responsible for the transmission of major infectious diseases. Recent advances in insect genomics and transformation technology provide new strategies for the control of insect borne pathogen transmission and insect pest management. One such strategy is the genetic modification of insects with genes that block pathogen development. Another is to suppress insect populations by releasing either sterile males or males carrying female-specific dominant lethal genes into the environment. Although significant progress has been made in the laboratory, further research is needed to extend these approaches to the field. These insect control strategies offer several advantages over conventional insecticide-based strategies. However, the release of genetically modified insects into the environment should proceed with great caution, after ensuring its safety, and acceptance by the target populations.
authors.affiliation: Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, Maryland, USA.
authors.forename: Eappen G
authors.initials: EG
authors.lastname: Abraham
authors.affiliation: Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, Maryland, USA.
authors.forename: Sung-Jae
authors.initials: SJ
authors.lastname: Cha
authors.affiliation: Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, Maryland, USA.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Jacobs-Lorena
keywords: conditional gene expression; insect genetic control; sterile insect technology; transposable element; vector borne disease