title: Effect of n-butyl-2-cyanoacrylate on the tensile strength and pressure resistance of tracheal anastomoses ex vivo.
abstract: OBJECTIVE
  To investigate the effects of n-butyl-2-cyanoacrylate on tracheal anastomoses in terms of increased tension and intraluminal pressure ex vivo.
  
  
  METHODS
  Ex vivo experimental study.
  
  
  METHODS
  Tertiary referral center (Department of Otolaryngology).
  
  
  METHODS
  Thirty sheep tracheas were used. Four cartilage rings were resected from the tracheas that were 20 cm in length. End-to-end anastomoses were performed by using Vicryl only (group 1), Vicryl and n-butyl-2-cyanoacrylate (group 2), and n-butyl-2-cyanoacrylate only (group 3). The amount of force to break off the anastomosis and the amount of intraluminal pressure to arouse air leakage through the anastomosis were measured.
  
  
  RESULTS
  The mean force required to break off was 171.9 ± 29.7 N in group 1, 164.8 ± 26 N in group 2, and 13.52 ± 2 N in group 3. The mean force required to break off in group 3 was significantly lower than those in groups 1 and 2 (P = .008 and P = .008, respectively). The mean pressure required to cause air leakage was 49.6 ± 9.1 mm Hg in group 1, 113 ± 14.4 mm Hg in group 2, and 15 ± 4.2 mm Hg in group 3. Group 2 was found to be more resistant to intraluminal pressure than groups 1 and 3 (P = .008 and P = .008, respectively).
  
  
  CONCLUSIONS
  n-Butyl-2-cyanoacrylate had no significant effect on tensile strength. However, its application on the suture line provided extra pressure resistance ex vivo. We believe that further studies need to be conducted to investigate its long-term effects and histological impact on tracheal anastomoses in vivo.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey ozgur.bicer@ibu.edu.tr.
authors.forename: Yusuf Ozgur
authors.initials: YO
authors.lastname: Bicer
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Koybasi
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kazaz
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Seyhan
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D004659:Enbucrilate / Q000494:pharmacology*; D066298:In Vitro Techniques; D011312:Pressure; D034561:Sheep, Domestic; D013536:Suture Techniques; D013718:Tensile Strength / Q000187:drug effects*; D014132:Trachea / Q000601:surgery*
chemical_list: D004659:Enbucrilate
keywords: anastomosis; cyanoacrylate; pressure; trachea