title: A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones.
abstract: A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.
authors.affiliation: Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P. O. Box 574, SE-751 23 Uppsala, Sweden. luke.odell@orgfarm.uu.se.
authors.forename: Marc Y
authors.initials: MY
authors.lastname: Stevens
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wieckowski
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Rajiv T
authors.initials: RT
authors.lastname: Sawant
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D007097:Imines; D052999:Quinazolinones