title: Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery.
abstract: OBJECTIVE
  To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery.
  
  
  METHODS
  We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables.
  
  
  RESULTS
  Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072).
  
  
  CONCLUSIONS
  COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.
authors.affiliation: Department of Nephrology & Hypertension, Diabetes & Endocrinology, Otto-von-Guericke University, Magdeburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Albert
authors.forename: Johanna
authors.initials: J
authors.lastname: Kube
authors.forename: Anja
authors.initials: A
authors.lastname: Haase-Fielitz
authors.forename: Annemarie
authors.initials: A
authors.lastname: Dittrich
authors.forename: Denny
authors.initials: D
authors.lastname: Schanze
authors.forename: Martin
authors.initials: M
authors.lastname: Zenker
authors.forename: Hermann
authors.initials: H
authors.lastname: Kuppe
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mertens
authors.forename: Michael
authors.initials: M
authors.lastname: Haase
mesh_terms: D058186:Acute Kidney Injury / Q000201:enzymology* / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000601:surgery*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000201:enzymology* / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D002394:Catechol O-Methyltransferase
keywords: COMT; NGAL; Val158Met SNP; acute kidney injury; midkine; neutrophil gelatinase-associated lipocalin; open heart surgery; rs4680; tubular stress