title: Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques.
abstract: The rhesus macaque serves as an animal model for Ebola virus (EBOV) infection. A thorough understanding of EBOV infection in this species would aid in further development of filovirus therapeutics and vaccines. In this study, pathological and immunological data from EBOV-infected rhesus macaques are presented. Changes in blood chemistries, hematology, coagulation, and immune parameters during infection, which were consistently observed in the animals, are presented. In an animal that survived challenge, a delay was observed in the detection of viral RNA and inflammatory cytokines and chemokines which may have contributed to survival. Collectively, these data add to the body of knowledge regarding EBOV pathogenesis in rhesus macaques and emphasize the reproducibility of the rhesus macaque challenge model.
authors.affiliation: 1 Department of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases (USAMRIID) , Frederick, Maryland.
authors.forename: Karen
authors.initials: K
authors.lastname: Martins
authors.forename: Christopher
authors.initials: C
authors.lastname: Cooper
authors.forename: Travis
authors.initials: T
authors.lastname: Warren
authors.forename: Jay
authors.initials: J
authors.lastname: Wells
authors.forename: Todd
authors.initials: T
authors.lastname: Bell
authors.forename: Jolynne
authors.initials: J
authors.lastname: Raymond
authors.forename: Kelly
authors.initials: K
authors.lastname: Stuthman
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Benko
authors.forename: Nicole
authors.initials: N
authors.lastname: Garza
authors.forename: Sean
authors.initials: S
authors.lastname: van Tongeren
authors.forename: Ginger
authors.initials: G
authors.lastname: Donnelly
authors.forename: Cary
authors.initials: C
authors.lastname: Retterer
authors.forename: Lian
authors.initials: L
authors.lastname: Dong
authors.forename: Sina
authors.initials: S
authors.lastname: Bavari
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000254:growth & development*; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000473:pathology* / Q000821:virology*; D008253:Macaca mulatta; D008297:Male; D018419:Primate Diseases / Q000473:pathology* / Q000821:virology*