title: The functional mechanism of simvastatin in experimental osteoporosis.
abstract: Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use of animal models, the treatment effectiveness of simvastatin on experimental osteoporosis was investigated and the functional mechanism was preliminarily explored. The results show that simvastatin significantly increased the mechanical parameters such as maximum load, stiffness, and energy-absorbing capacity, and improved the microarchitecture. They indicated that the antiosteoporosis activity of simvastatin may be due to the promotion of proliferation and differentiation of osteoblasts. Simvastatin was effective in treating experimental osteoporosis. This study provides necessary experimental evidence for the clinical application of simvastatin in osteoporosis treatment.
authors.affiliation: Kunming Research Center for Molecular Medicine, Kunming University, Kunming, 650214, People's Republic of China.|Department of Endocrinology, Second Affiliated Hospital of Kunming Medical University, Kunming, 650500, People's Republic of China.|School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Dai
authors.affiliation: Kunming Research Center for Molecular Medicine, Kunming University, Kunming, 650214, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Emergency Medicine and Intensive Care Unit, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People's Republic of China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Wu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
authors.forename: Lanjie
authors.initials: L
authors.lastname: Xue
authors.affiliation: Kunming Research Center for Molecular Medicine, Kunming University, Kunming, 650214, People's Republic of China.
authors.forename: Dekai
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Kunming Research Center for Molecular Medicine, Kunming University, Kunming, 650214, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Shen
authors.affiliation: Department of Emergency Medicine and Intensive Care Unit, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People's Republic of China. 596829191@qq.com.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Kunming Research Center for Molecular Medicine, Kunming University, Kunming, 650214, People's Republic of China. humin999@aliyun.com.|Department of Endocrinology, Second Affiliated Hospital of Kunming Medical University, Kunming, 650500, People's Republic of China. humin999@aliyun.com.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control*; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D019821:Simvastatin
keywords: Animal model; Bone mineral density; Osteoblast; Osteoporosis; Simvastatin