title: Territrem and butyrolactone derivatives from a marine-derived fungus Aspergillus terreus.
abstract: Seventeen lactones including eight territrem derivatives (1-8) and nine butyrolactone derivatives (9-17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1-3 and 9-10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1-17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL-1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL-1 toward barnacle Balanus amphitrite larvae, respectively.
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China. nongxuhua4883@163.com.
authors.forename: Xu-Hua
authors.initials: XH
authors.lastname: Nong
authors.affiliation: Jinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, China. twangyf@jnu.edu.cn.
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China. zhangxiaoyong@scsio.ac.cn.
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Jinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, China. 1208000466@qq.com.
authors.forename: Mu-Ping
authors.initials: MP
authors.lastname: Zhou
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China. xuxinya@scsio.ac.cn.
authors.forename: Xin-Ya
authors.initials: XY
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China. shuhuaqi@scsio.ac.cn.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002460:Cell Line; D002522:Chlorocebus aethiops; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008386:Marine Biology; D012275:Oryza / Q000382:microbiology; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology; D001468:Thoracica / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D002800:Cholinesterase Inhibitors; D007783:Lactones; D011714:Pyrans; D000110:Acetylcholinesterase