title: Surgical Materials: Current Challenges and Nano-enabled Solutions.
abstract: Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications.
authors.affiliation: Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Annabi
authors.affiliation: Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tamayol
authors.affiliation: Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
authors.forename: Su Ryon
authors.initials: SR
authors.lastname: Shin
authors.affiliation: Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, United Kingdom.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Ghaemmaghami
authors.affiliation: Department of Biomedical Engineering, Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
authors.affiliation: Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA ; Department of Biomedical Engineering, Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA ; Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea ; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini