title: Dynamic intervention: pathogen disarmament of mitochondrial-based immune surveillance.
abstract: In this issue of Cell Host & Microbe, Suzuki et al. (2014) describe a Vibrio cholerae Type-III-secreted effector that targets mitochondrial dynamics to dampen host innate immune signaling. This suggests that mammalian hosts possess surveillance mechanisms to monitor pathogen-mediated alterations in the integrity of normal cellular processes and organelles.
authors.affiliation: Department of Microbiology, University of Illinois, Urbana, IL 61801, USA.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Holland
authors.affiliation: Department of Microbiology, University of Illinois, Urbana, IL 61801, USA. Electronic address: sblanke@illinois.edu.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Blanke
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D006801:Humans; D007113:Immunity, Innate; D063154:Mitochondrial Dynamics / Q000502:physiology*; D014734:Vibrio cholerae / Q000276:immunology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D020741:rho GTP-Binding Proteins