title: Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults.
abstract: The blood pressure-lowering effect of dairy products holds the potential to decrease the risk of cardiovascular disease (CVD). An open question is if the successful expression of functional properties of the probiotic strain depends on host biomarkers and/or food matrix properties. The probiotic Lactobacillus plantarum strain TENSIA® (DSM 21380) is a novel microorganism with antimicrobial and antihypertensive functional properties. The aim of this study was to characterise the functional properties of the probiotic L. plantarum TENSIA and compare its effects on host anthropometric, clinical, and blood biomarkers when consumed with cheese or yoghurt. This study involved two double-blinded randomised placebo-controlled exploratory trials (ISRCTN15061552 and ISRCTN79645828) of healthy adults over a three-week period. The three-week consumption of probiotic L. plantarum TENSIA in a daily dose of 1×1010 cfu in probiotic cheese or a daily dose of 6×109 cfu in yoghurt with different content of carbohydrates, proteins, and lipids did not significantly change the body mass index (BMI), plasma glucose and lipid levels, or inflammatory markers in the blood. Reduced lowered systolic and diastolic blood pressure values were detected, regardless of food matrix or baseline values for blood pressure and BMI. In conclusion, our study showed that three-week consumption of the probiotic L. plantarum TENSIA either in cheese or yoghurt lowered diastolic and systolic blood pressure regardless of food matrix and baseline values of blood pressure and BMI, confirming the impact of the functional properties of the probiotic strain in decreasing CVD risk.
authors.affiliation: Bio-Competence Centre of Healthy Dairy Products LLC, Kreutzwaldi 1, 51014, Tartu, Estonia Department of Microbiology, Faculty of Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia.
authors.forename: P
authors.initials: P
authors.lastname: Hütt
authors.affiliation: Bio-Competence Centre of Healthy Dairy Products LLC, Kreutzwaldi 1, 51014, Tartu, Estonia.
authors.forename: E
authors.initials: E
authors.lastname: Songisepp
authors.affiliation: Bio-Competence Centre of Healthy Dairy Products LLC, Kreutzwaldi 1, 51014, Tartu, Estonia.
authors.forename: M
authors.initials: M
authors.lastname: Rätsep
authors.affiliation: Department of Bio- and Translational Medicine, Faculty of Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia.
authors.forename: R
authors.initials: R
authors.lastname: Mahlapuu
authors.affiliation: Department of Bio- and Translational Medicine, Faculty of Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia.
authors.forename: K
authors.initials: K
authors.lastname: Kilk
authors.affiliation: Department of Microbiology, Faculty of Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia.
authors.forename: M
authors.initials: M
authors.lastname: Mikelsaar
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000178:diet therapy / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology*; D002611:Cheese / Q000382:microbiology*; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000378:metabolism*; D015014:Yogurt / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D008055:Lipids
keywords: Lactobacillus plantarum TENSIA; food matrix; functional property; host biomarker