title: Pharmaceutical properties of supramolecular assembly of co-loaded cardanol/triazole-halloysite systems.
abstract: Halloysite nanotubes were explored as drug carrier for cardanol, which is considered as a promising natural anticancer active species. To this aim, besides the pristine nanoclay, a chemical modification of the nanocarrier was performed by attaching triazolium salts with different hydrophobicity at the outer surface of the hollow nanotubes. The interaction between cardanol and nanotubes was highlighted in solution by HPLC. This method proved the loading of the drug into the nanotubes. The solid dried complexes formed by pristine and modified halloysite with the cardanol were characterized by IR spectroscopy, thermogravimetric analysis as well as water contact angle to evidence the structure, thermal properties and wettability of the obtained materials. The kinetics of cardanol release as well as cell viability experiments provided promising results that put forward a new strategy for potential applications of cardanol as active antiproliferative molecule and clay nanotubes as drug carrier.
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Massaro
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Carmelo G
authors.initials: CG
authors.lastname: Colletti
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Noto
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy. Electronic address: serena.riela@unipa.it.
authors.forename: Serena
authors.initials: S
authors.lastname: Riela
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute e Materno Infantile "G. D'Alessandro", Area Funzionale di Farmacologia, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Poma
authors.affiliation: Dipartimento di Chimica "G. Ciamician", Università di Bologna, via San Giacomo 11, 40126 Bologna, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Guernelli
authors.affiliation: Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Parisi
authors.affiliation: Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Stefana
authors.initials: S
authors.lastname: Milioto
authors.affiliation: Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy. Electronic address: giuseppe.lazzara@unipa.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lazzara
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077215:Clay; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D065546:Drug Liberation; D006801:Humans; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry
chemical_list: D000538:Aluminum Silicates; D000970:Antineoplastic Agents; D004337:Drug Carriers; D010636:Phenols; D014230:Triazoles; C038590:cardanol; D000077215:Clay
keywords: Cardanol; Drug carrier; HPLC; Halloysite; Hepatocellular carcinoma