title: Intramolecular etherification and polyene cyclization of π-activated alcohols promoted by hot water.
abstract: Hot water, acting as a mildly acidic catalyst, efficiently promoted intramolecular direct nucleophilic substitution reactions of unsaturated alcohols with heteroatom or carbon nucleophiles. In a mixed solvent of water and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), polyene cyclizations using allylic alcohols as initiators gave the desired cyclized products, and in neat HFIP, a tricyclization reaction gave a tetracyclic product in 51% chemical yield.
authors.forename: Feng-Zhi
authors.initials: FZ
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Qu