title: Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women.
abstract: The aim of this study was to determine whether Human Papillomavirus was present in tongue and periodontium of periodontally healthy and diseased women who had genital lesions caused by the virus. Thirty non-menopausal women, systemically healthy and diagnosed with gynecological HPV lesions, were referred by the Gynecology Service Department of the University Maternal Neonatal Hospital of the City of Cordoba. Anamnesis, oral mucosa examination and periodontal clinical assessment were performed. Three brush samples were taken per patient: two from the same periodontal location (external epithelium of the gum and internal epithelium of the periodontal sulcus/pocket), and the third from the tongue. The 90 samples were submitted to Pap cytology and Polymerase Chain Reaction. The data were statistically analyzed by "Chi Square Test" (χ2) and "Kappa Index" (κ). High prevalence of HPV was found in the tongue (30%) and periodontal tissues (15%). High risk (HR) genotype -16 was detected with the highest percentage (67%), and genotypes -52 and -6 were also detected. Whenever HPV was present in periodontal location, it was also identified in the tongue of the same patients, of whom 88.89% reported that they practiced oral sex. Is worth noting the clinical finding of stomatologic lesions compatible with foliate papillitis in patients with positive intraoral HPV. High prevalence of HPV was found in the female population in Cordoba, with genotype -16 being detected at the highest percentage. No positive correlation was found between HPV and higher incidence and severity of periodontal lesions.
authors.affiliation: Department of Periodontics, Independencia Foundation for Advanced Studies in Dentistry, Cordoba, Argentina.
authors.forename: Liliana
authors.initials: L
authors.lastname: Fuster-Rossello
authors.affiliation: Department of Periodontics, Independencia Foundation for Advanced Studies in Dentistry, Cordoba, Argentina.
authors.forename: Estela
authors.initials: E
authors.lastname: Ribotta
authors.affiliation: Institute of Virology, National University of Cordoba, Argentina.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Cuffini
authors.affiliation: Department of Gynecology, Maternity and Neonatology, National University Hospital of Cordoba, Argentina.
authors.forename: Margarita
authors.initials: M
authors.lastname: Fuster-Juan
mesh_terms: D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D003430:Cross-Sectional Studies; D003581:Cytodiagnosis / Q000379:methods; D003774:Dental Plaque Index; D005260:Female; D005831:Genital Diseases, Female / Q000821:virology*; D005881:Gingiva / Q000821:virology; D005891:Gingivitis / Q000821:virology; D005928:Glossitis / Q000821:virology; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D009061:Mouth Mucosa / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D017622:Periodontal Attachment Loss / Q000821:virology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000821:virology; D010519:Periodontium / Q000821:virology; D012725:Sexual Behavior; D014059:Tongue / Q000821:virology; D055815:Young Adult