title: Spatially gradated hydrogel platform as a 3D engineered tumor microenvironment.
abstract: There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.
authors.affiliation: The Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois, 61801, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Pedron
authors.forename: Eftalda
authors.initials: E
authors.lastname: Becka
authors.forename: Brendan A
authors.initials: BA
authors.lastname: Harley
mesh_terms: D040761:Biomimetic Materials; D002452:Cell Count; D045744:Cell Line, Tumor; D005780:Gelatin; D015870:Gene Expression; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020100:Hydrogels; D044085:Microfluidics / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*; D059016:Tumor Microenvironment
chemical_list: D020100:Hydrogels; D005780:Gelatin
keywords: glioblastoma; gradient; hydrogel; microfluidics; tumor microenvironment