title: Achondroplasia and multiple-suture craniosynostosis.
abstract: Genetic mutations in the fibroblast growth factor receptor 3 gene may lead to achondroplasia or syndromic forms of craniosynostosis. Despite sharing a common genetic basis, craniosynostosis has rarely been described in cases of confirmed achondroplasia. We report an infant with achondroplasia who developed progressive multiple-suture craniosynostosis to discuss the genetic link between these clinical entities and to describe the technical challenges associated with the operative management.
authors.affiliation: From the *Divisions of Plastic Surgery, †Neurosurgery, and ‡Anesthesiology, Sedation and Perioperative Medicine, Children's National Medical Center, Washington, DC.
authors.forename: Frank P
authors.initials: FP
authors.lastname: Albino
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Wood
authors.forename: Chima O
authors.initials: CO
authors.lastname: Oluigbo
authors.forename: Angela C
authors.initials: AC
authors.lastname: Lee
authors.forename: Albert K
authors.initials: AK
authors.lastname: Oh
authors.forename: Gary F
authors.initials: GF
authors.lastname: Rogers
mesh_terms: D000130:Achondroplasia / Q000150:complications / Q000235:genetics*; D003398:Craniosynostoses / Q000150:complications / Q000235:genetics* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*
chemical_list: D051498:Receptor, Fibroblast Growth Factor, Type 3