title: The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases.
abstract: The identification of the estrogen-related receptors (ERRs) as the first orphan nuclear receptors ignited a new era in molecular endocrinology, which led to the discovery of new ligand-dependent response systems. Although ERR subfamily members have yet to be associated with a natural ligand, the characterization of these orphan receptors has demonstrated that they occupy a strategic node in the transcriptional control of cellular energy metabolism. In particular, ERRs are required for the response to various environmental challenges that require high energy levels by the organism. As central regulators of energy homeostasis, ERRs may also be implicated in the etiology of metabolic disorders, such as type 2 diabetes and metabolic syndrome. Here, we review the recent evidence that further highlights the role of ERRs in metabolic control, particularly in liver and skeletal muscle, and their likely involvement in metabolic diseases. Consequently, we also explore the promises and pitfalls of ERRs as potential therapeutic targets.
authors.affiliation: Goodman Cancer Research Center, McGill University, Montréal, Québec, H3G 1Y6, Canada.
authors.forename: Étienne
authors.initials: É
authors.lastname: Audet-Walsh
authors.affiliation: 1] Goodman Cancer Research Center, McGill University, Montréal, Québec, H3G 1Y6, Canada [2] Departments of Biochemistry, Medicine and Oncology, McGill University, Montréal, Québec, H3G 1Y6, Canada.
authors.forename: Vincent
authors.initials: V
authors.lastname: Giguére
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008024:Ligands; D008659:Metabolic Diseases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D008024:Ligands; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor