title: Electronic structure of antibiotic erythromycin.
abstract: The electronic structure of erythromycin A (ERYMA) molecule has been studied by UV photoelectron spectroscopy and assigned (in the low ionization energy region only) by empirical arguments. The two orbitals with highest energy (lowest ionization energy) are localized on the nitrogen of the desosamine sugar functional group and on the ester group of macrolide (lactone) ring. We discuss how these orbital energies can help to rationalize the known mode of binding of ERYMA to their biological receptors.
authors.affiliation: Charles Sturt University, POB 883, Orange, NSW 2800, Australia. Electronic address: inovak@csu.edu.au.
authors.forename: Igor
authors.initials: I
authors.lastname: Novak
authors.affiliation: Physical Chemistry Division, "R. Bošković" Institute, HR-10000 Zagreb, Croatia. Electronic address: bkovac@irb.hr.
authors.forename: Branka
authors.initials: B
authors.lastname: Kovač
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D004583:Electrons; D004917:Erythromycin / Q000737:chemistry* / Q000494:pharmacology; D008027:Light
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin
keywords: Erythromycin; Photoelectron spectroscopy