title: New avenue to inhibit Ras signaling.
abstract: Inhibition of Ras-stimulating enzymes is a possible avenue to treat Ras-driven diseases. In this issue of Chemistry & Biology, Evelyn and coworkers report an inhibitor for one such enzyme, Sos1, capable of impairing wild-type Ras signaling in cells.
authors.affiliation: Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain. Electronic address: xbustelo@usal.es.
authors.forename: Xosé R
authors.initials: XR
authors.lastname: Bustelo
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D020837:SOS1 Protein / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries / Q000494:pharmacology*
chemical_list: D020837:SOS1 Protein; D054852:Small Molecule Libraries