title: Vaginal carcinoma in a young woman who underwent fertility-sparing treatment involving chemotherapy and conservative surgery.
abstract: Vaginal carcinoma is a rare gynecological malignancy that is usually treated by radiation therapy and/or surgery combined with chemotherapy. Here, we report a case of invasive vaginal carcinoma in a young woman who underwent fertility-sparing treatment involving neoadjuvant chemotherapy and conservative surgery. A 36-year-old non-parous woman had a solid tumor in the vagina. Positron emission tomography/computed tomography showed a tumor in the vagina with high FDG uptake (SUV = 17.33) but no metastatic lesions. The patient was diagnosed with vaginal squamous cell carcinoma, FIGO stage I, T1N0M0. Because she wished to retain her fertility, neoadjuvant chemotherapy consisting of irinotecan hydrochloride and nedaplatin was initiated. After four courses of chemotherapy, partial vaginectomy was carried out and the pathological diagnosis of the residual lesion was VAIN 3. Following two further courses of the same chemotherapy, she obtained complete response, and has shown no evidence of disease for 14 months.
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mabuchi
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Yahata
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Kobayashi
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tanizaki
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Minami
authors.affiliation: Department of Obstetrics and Gynecology, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ino
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D000077146:Irinotecan; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012074:Remission Induction; D014592:Uterine Hemorrhage / Q000209:etiology / Q000517:prevention & control; D014621:Vagina / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*
chemical_list: D009944:Organoplatinum Compounds; D000077146:Irinotecan; C053989:nedaplatin; D002166:Camptothecin
keywords: chemotherapy; fertility-sparing treatment; squamous cell carcinoma; vaginal carcinoma