title: Elevated serum 25(OH)-vitamin D levels are negatively correlated with molar-incisor hypomineralization.
abstract: To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS > 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol/l (standard deviation 22.0 nmol/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television/personal computer (TV/PC) viewing hours, a 10 nmol/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters.
authors.affiliation: Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians-University of Munich, Munich, Germany jkuehn@dent.med.uni-muenchen.de.
authors.forename: J
authors.initials: J
authors.lastname: Kühnisch
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Centre for Environmental Health, Neuherberg, Germany Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Thiering
authors.affiliation: Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: Department of Preventive and Paediatric Dentistry, Friedrich-Schiller-University of Jena, Jena, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Heinrich-Weltzien
authors.affiliation: Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Hickel
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Centre for Environmental Health, Neuherberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004245:DMF Index; D003731:Dental Caries / Q000453:epidemiology; D003744:Dental Enamel Hypoplasia / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006304:Health Status; D006801:Humans; D007182:Income / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D008838:Microcomputers / Q000706:statistics & numerical data; D009909:Oral Health; D010290:Parents / Q000193:education; D012737:Sex Factors; D013690:Television / Q000706:statistics & numerical data; D013997:Time Factors; D014094:Tooth, Deciduous / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: birth cohort study; caries; dental enamel; developmental defect; epidemiology; prevention