title: Unpredictable drug reaction in a child with Cornelia de Lange syndrome.
abstract: METHODS
  Preoperative use of midazolam sedation is mandatory during induction of anesthesia in noncooperative and hyperactive children to prevent possible obstacles. Unusual drug reactions rarely occur in patients undergoing anesthesia or in intensive care unit. This report describes an unpredictable drug reaction after a routine midazolam premedication in a patient with no history of allergy. There has been no literature data yet to show that midazolam can provoke respiratory problems in patients with Cornelia de Lange Syndrome.
  
  
  CONCLUSIONS
  In our opinion midazolam should be avoided in patients with Cornelia de Lange Syndrome, which we enforced after first unpredictable reaction.
authors.affiliation: Department of Anesthesia, University Children's Hospital, Belgrade, Serbia, mamarija74@gmail.com.
authors.forename: Marija
authors.initials: M
authors.lastname: Stevic
authors.forename: Irina
authors.initials: I
authors.lastname: Milojevic
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Bokun
authors.forename: Dusica
authors.initials: D
authors.lastname: Simic
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D002675:Child, Preschool; D003635:De Lange Syndrome / Q000175:diagnosis / Q000601:surgery*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000009:adverse effects*
chemical_list: D014151:Anti-Anxiety Agents; D008874:Midazolam