title: Computational Construction of Antibody-Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker.
abstract: Antibody-drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed.
authors.affiliation: School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece. ; Bioinformatics and Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
authors.forename: Arianna
authors.initials: A
authors.lastname: Filntisi
authors.affiliation: Bioinformatics and Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vlachakis
authors.affiliation: School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
authors.forename: George K
authors.initials: GK
authors.lastname: Matsopoulos
authors.affiliation: Bioinformatics and Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
authors.forename: Sophia
authors.initials: S
authors.lastname: Kossida
keywords: antibody–drug conjugate; cancer; targeted therapy