title: Helper T-cell type 17 cytokines and immunity in the lung.
abstract: The HIV epidemic has clearly demonstrated the critical role CD4(+) T cells play in preventing opportunistic infections in the lung. The types of CD4(+) effector T-cell populations in the lung have significantly expanded over the last 8-10 years with the discovery of helper T type 17 cells, and this review summarizes the field and discusses how these effector cells may be exploited to augment mucosal immunity in the lung.
authors.affiliation: Department of Pediatrics, Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D008168:Lung / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: epithelium; interleukins; pneumonia