title: Acute rejection of a cryopreserved arterial homograft.
abstract: The use of arterial homograft is indicated especially in case of prosthetic graft infections after bypass surgery. We report the case of a patient who experienced the loss of a cryopreserved femoral artery caused by an acute rejection. This homograft had to be explanted 1 month after implantation because of an acute aneurysmal deterioration. Histology of the explanted artery showed inflammatory cells infiltration, pseudoaneurysms and necrosis. It was then replaced by a second cryopreserved femoral artery which is currently well tolerated. This first case of acute rejection of a cryopreserved artery, to our knowledge, raises again the question of the immunogenicity of cryopreserved homografts. The case report is followed by a brief discussion.
authors.affiliation: European Homograft Bank, c/o Military Hospital Queen Astrid, Rue Bruynstraat, 1120, Brussels, Belgium, jerome.soquet@gmail.com.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Soquet
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Chambon
authors.forename: Yves
authors.initials: Y
authors.lastname: Goffin
authors.forename: Ramadan
authors.initials: R
authors.lastname: Jashari
mesh_terms: D000208:Acute Disease; D000328:Adult; D015925:Cryopreservation; D005263:Femoral Artery / Q000637:transplantation*; D006084:Graft Rejection / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D013927:Thrombosis / Q000150:complications* / Q000601:surgery*; D017211:Treatment Failure; D016896:Treatment Outcome