title: Renal protective effects of Porphyra dentate aqueous extract in diabetic mice.
abstract: Background: Purple laver ((Porphyra dentate) is a popular edible seaweed in Asia. This study examined protective effects of extract from purple laver extract (PLE) in diabetic mice. Methods: Content of carotenoids and anthocyanins in PLE was analyzed. PLE at 0.5 and 1% was supplied for 7 weeks. Results: PLE was rich in anthocyanins. PLE intake at 0.5 and 1% lowered plasma glucose level (P<0.05); only at 1% raised plasma insulin level, and decreased plasma triglyceride and total cholesterol levels (P<0.05). PLE treatments at 1% lowered hepatic triglyceride and total cholesterol (P<0.05); it reduced renal reactive oxygen species level (P<0.05); retained renal glutathione level, maintaining renal glutathione peroxidase and catalase activities (P<0.05). Conclusion:Porphyra dentateaqueous extract could attenuate diabetic progression via anti-oxidative and lipid lowering effects. This seaweed could be considered as potent healthy food, and used for personalized medicine.
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung, Taiwan ; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Pei-Chun
authors.initials: PC
authors.lastname: Chao
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung, Taiwan ; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Cheng-Chin
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung, Taiwan ; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Wen-Hu
authors.initials: WH
authors.lastname: Liu
keywords: Diabetes; Hyperlipidemia; Oxidative stress; Porphyra dentate