title: In search of naivety.
abstract: Devising a cell culture method that maintains human pluripotent stem cells (PSCs) in a state similar to naive mouse embryonic stem cells (ESCs) has been a much sought after goal in recent years. Here I consider the historical background to this quest and ask why it is considered consequential.
authors.affiliation: University of Melbourne, Florey Institute of Neuroscience and Mental Health, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3010, Australia. Electronic address: mpera@unimelb.edu.au.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Pera
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*