title: Workshop on use of intravenous immunoglobulin in hand, foot and mouth disease in Southeast Asia.
abstract: The South East Asia Infectious Disease Clinical Research Network convened subject matter experts at a workshop to make consensus recommendations for study design of a clinical trial for use of intravenous immunoglobulin (IVIg) in severe hand, foot and mouth disease (HFMD). HFMD is a highly contagious emerging infection among children in the region, a small proportion of whom develop neurologic and cardiopulmonary complications with high case-fatality rates. The use of IVIg for treatment of severe disease is widespread and a part of local, national, and international guidelines, but no clinical evidence warrants the use of this drug, which is expensive and has potentially serious side effects. During a 2-day workshop in March 2014, a group of HFMD experts reviewed the current evidence related to use of IVIg in HFMD and discussed potential study design, feasibility, inclusion and exclusion criteria, sample size, primary and secondary endpoints, and subsidiary studies for a randomized, placebo-controlled trial.
authors.forename: Sokkosal
authors.initials: S
authors.lastname: Chea
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Cheng
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokephaibulkit
authors.forename: Tawee
authors.initials: T
authors.lastname: Chotpitayasunondh
authors.forename: H
authors.initials: H
authors.lastname: Rogier van Doorn
authors.forename: Zen
authors.initials: Z
authors.lastname: Hafy
authors.forename: Surinda
authors.initials: S
authors.lastname: Kawichai
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Liu
authors.forename: Nguyen Tran
authors.initials: NT
authors.lastname: Nam
authors.forename: Mong How
authors.initials: MH
authors.lastname: Ooi
authors.forename: Marcel
authors.initials: M
authors.lastname: Wolbers
authors.forename: Mei
authors.initials: M
authors.lastname: Zeng
mesh_terms: D001210:Asia, Southeastern; D006232:Hand, Foot and Mouth Disease / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D016756:Immunoglobulins, Intravenous