title: Clinical significance of soluble CD26 in malignant pleural mesothelioma.
abstract: There is no established single diagnostic marker for malignant pleural mesothelioma (MPM). CD26 is a 110 kDa, multifunctional, membrane-bound glycoprotein that has dipeptidyl peptidase IV (DPPIV) enzyme activity. The aim of this study was to evaluate the clinical significance of soluble CD26 (sCD26) in patients with MPM. The study included 80 MPM patients, 79 subjects with past asbestos exposure (SPE), and 134 patients with other benign pleural diseases (OPD) that were included as a control group. sCD26 levels and DPPIV activity in serum and/or pleural fluid were determined using an ELISA kit. Serum sCD26 levels and DPPIV enzyme activity in patients with MPM were significantly decreased compared with those in the SPE group (P = 0.000). The level of serum sCD26 was significantly decreased in patients with advanced stages of MPM compared with those with earlier stages (P = 0.047). The median OS of patients with MPM who had higher DPPIV enzyme activity was significantly longer than that of those with lower DPPIV enzyme activity (P = 0.032). The sCD26 levels in the pleural fluid of MPM patients with an epithelioid subtype were significantly increased compared with the OPD cohort (P = 0.012). Moreover, DPPIV enzyme activity in the pleural fluid of patients with MPM with an epithelioid subtype were significantly increased compared with those in the OPD cohort (P = 0.009). Patients with MPM who had lower specific DPPIV activity, determined as DPPIV/sCD26, showed significantly prolonged survival compared with those with higher specific DPPIV activity (P = 0.028). Serum sCD26 and DPPIV enzyme activity appear to be useful biomarkers for differentiating patients with MPM from SPE. The sCD26 levels or DPPIV enzyme activity in pleural fluid appear to be biomarkers in patients with an epithelioid subtype of MPM. DPPIV activity in serum or pleural fluid appears to be predictive for the prognosis of patients with MPM.
authors.affiliation: Department of Medical Oncology, Okayama Rosai Hospital, Okayama, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fujimoto
authors.affiliation: Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ohnuma
authors.affiliation: Department of Medical Oncology and Clinical Research, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Yamaguchi, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Aoe
authors.affiliation: Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Hosono
authors.affiliation: Department of Pathology, Keio University school of Medicine, Tokyo, Japan.
authors.forename: Taketo
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Department of Internal Medicine, Okayama Rosai Hospital, Okayama, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Kishimoto
authors.affiliation: Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Chikao
authors.initials: C
authors.lastname: Morimoto
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D003937:Diagnosis, Differential; D018819:Dipeptidyl Peptidase 4 / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010994:Pleura / Q000201:enzymology* / Q000473:pathology; D010997:Pleural Neoplasms / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4