title: Insights from space: potential role of diet in the spatial organization of chromosomes.
abstract: We can now sequence and identify genome wide epigenetic patterns and perform a variety of "genomic experiments" within relatively short periods of time-ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome.
authors.affiliation: The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand. justin.osullivan@auckland.ac.nz.
authors.forename: Justin M
authors.initials: JM
authors.lastname: O'Sullivan
authors.affiliation: The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand. m.doynova@auckland.ac.nz.
authors.forename: Malina D
authors.initials: MD
authors.lastname: Doynova
authors.affiliation: Department of Pathology, Dunedin School of Medicine, The University of Otago, P.O. Box 913, Dunedin 9054, New Zealand. jisha.antony@otago.ac.nz.
authors.forename: Jisha
authors.initials: J
authors.lastname: Antony
authors.affiliation: The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand. f.pichlmuller@auckland.ac.nz.
authors.forename: Florian
authors.initials: F
authors.lastname: Pichlmuller
authors.affiliation: Department of Pathology, Dunedin School of Medicine, The University of Otago, P.O. Box 913, Dunedin 9054, New Zealand. julia.horsfield@otago.ac.nz.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Horsfield
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D019175:DNA Methylation; D004032:Diet; D044127:Epigenesis, Genetic; D057890:Epigenomics; D004967:Estrogens / Q000378:metabolism; D016678:Genome; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D054647:Nutrigenomics
chemical_list: D002843:Chromatin; D004967:Estrogens; D006657:Histones