title: Outcomes of extremely preterm infants after delivery room cardiopulmonary resuscitation in a population-based cohort.
abstract: OBJECTIVE
  To describe the relationship of delivery room cardiopulmonary resuscitation (DR-CPR) to short-term outcomes of extremely preterm infants.
  
  
  METHODS
  This was a cohort study of 22 to 27+6/7 weeks gestational age (GA) infants during 2005 to 2011. DR-CPR was defined as chest compressions and/or epinephrine administration. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) associated with DR-CPR; analysis was stratified by GA.
  
  
  RESULTS
  Of the 13 758 infants, 856 (6.2%) received DR-CPR. Infants 22 to 23+6/7 weeks receiving DR-CPR had similar outcomes to non-recipients. Infants 24 to 25+6/7 weeks receiving DR-CPR had more severe intraventricular hemorrhage (OR 1.36, 95% CI 1.07, 1.72). Infants 26 to 27+6/7 weeks receiving DR-CPR were more likely to die (OR 1.81, 95% CI 1.30, 2.51) and have intraventricular hemorrhage (OR 2.10, 95% CI 1.56, 2.82). Adjusted hospital DR-CPR rates varied widely (median 5.7%).
  
  
  CONCLUSIONS
  Premature infants receiving DR-CPR had worse outcomes. Mortality and morbidity varied by GA.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, CA, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Handley
authors.affiliation: Department of Pediatrics, University of California, San Francisco, CA, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Wyckoff
authors.affiliation: Department of Pediatrics, Stanford University, California Perinatal Quality Care Collaborative, Stanford, CA, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
mesh_terms: D002140:California; D016887:Cardiopulmonary Resuscitation / Q000706:statistics & numerical data*; D015331:Cohort Studies; D003696:Delivery Rooms; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D005865:Gestational Age; D006336:Heart Massage / Q000379:methods*; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012044:Regression Analysis; D016896:Treatment Outcome
chemical_list: D004837:Epinephrine