title: Anti-obesity effect of (8-E)-niizhenide, a secoiridoid from Ligustrum lucidum, in high-fat diet-induced obese mice.
abstract: The effect of the extract of Ligustrumn lucidum fruits (LFE) and its major secoiridoid (LFS), (8-E)-nüzhenide, on obesity was investigated using high fat-diet (HFD)-induced C58BL/6J obese mice. LFE and LFS were administered at the doses of 300 mg/kg and 30 mg/kg, respectively, for 6 weeks. The anti-obesity activity was evaluated by measuring body weight, epididymal fat and metabolic plasma parameters. On Day 42, the body weight of the LFS-treated group was significantly lower compared with the HFD-treated group. Body weight gain was also reduced by 23.2% and 32.0% in the LFE- and LFS-treated groups, respectively, compared with the HFD group. In addition, the weight of the epididymal fat in the mice was significantly decreased in the HFD+LFS group. The food efficiency ratios (FERs) of the HFD+LFE and HFD+LFS groups were also lower compared with the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD+LFE and HFD+LFS groups. In particular, the increased triglyceride values were significantly reduced in the HFD+LFS group. These results show that treatment with LFE and LFS decreased HFD-induced obesity, mainly by improving metabolic parameters, such as fats and triglycerides. Therefore, LFE and LFS have potential benefits in regulation of obesity.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Seon Beom
authors.initials: SB
authors.lastname: Kim
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Jo
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Kim
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Oh
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D039823:Iridoids / Q000737:chemistry / Q000627:therapeutic use*; D031659:Ligustrum / Q000737:chemistry*; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology
chemical_list: D007004:Hypoglycemic Agents; D039823:Iridoids