title: Targeting ions-induced autophagy in cancer.
abstract: Autophagy is an important cellular homeostasis pathway, but its role in cancer remains to be fully elucidated. In this issue of Cancer Cell, Hall and colleagues describe a TRPM3-dependent autophagy pathway that is selectively important for clear cell renal cell carcinoma and can be effectively inhibited.
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Biology, University of Tor Vergata, 00173 Rome, Italy; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cecconi
authors.affiliation: Unit of Cell Death and Metabolism, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark. Electronic address: mj@cancer.dk.
authors.forename: Marja
authors.initials: M
authors.lastname: Jäättelä
mesh_terms: D000818:Animals; D001343:Autophagy; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology*; D050053:TRPM Cation Channels / Q000235:genetics*
chemical_list: C549404:MIRN204 microRNA, human; D035683:MicroRNAs; D050053:TRPM Cation Channels; C475667:TRPM3 protein, human