title: Evaluation of the Efficacy of Tranexamic Acid on the Surgical Field in Primary Cleft Palate Surgery on Children-A Prospective, Randomized Clinical Study.
abstract: To assess the effect of tranexamic acid on the quality of the surgical field.
  
  
  
  Prospective, randomized, double-blind study.
  
  
  
  Institutional, tertiary referral hospital.
  
  
  
  American Society of Anesthesiologists physical status class I patients, aged 8 to 60 months with Group II or III (Balakrishnan's classification) clefts scheduled for cleft palate repair.
  
  
  
  Children were randomized into two groups. The control group received saline, and the tranexamic acid group received tranexamic acid 10 mg/kg as a bolus, 15 minutes before incision.
  
  
  
  Grade of surgical field on a 10-point scale, surgeon satisfaction, and primary hemorrhage.
  
  
  
  Significant improvements were noted in surgeon satisfaction and median grade of assessment of the surgical field (4 [interquartile range, 4 to 6] in the control group vs. 3 [interquartile range, 2 to 4] in the test group; P = .003) in the tranexamic acid group compared to the control group.
  
  
  
  Preincision administration of 10 mg/kg of tranexamic acid significantly improved the surgical field during cleft palate repair.
authors.forename: Padmaja
authors.initials: P
authors.lastname: Durga
authors.forename: Parvathi
authors.initials: P
authors.lastname: Raavula
authors.forename: Indira
authors.initials: I
authors.lastname: Gurajala
authors.forename: Poojita
authors.initials: P
authors.lastname: Gunnam
authors.forename: Prardhana
authors.initials: P
authors.lastname: Veerabathula
authors.forename: Mukund
authors.initials: M
authors.lastname: Reddy
authors.forename: Omkar
authors.initials: O
authors.lastname: Upputuri
authors.forename: Gopinath
authors.initials: G
authors.lastname: Ramachandran
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002675:Child, Preschool; D002972:Cleft Palate / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: cleft palate; palatoplasty; pediatric; satisfaction; surgical field; tranexamic acid