title: Primary laryngeal cancer-derived miR-193b induces interleukin-10-expression monocytes.
abstract: The pathogenesis of laryngeal cancer (LC) is unclear. Published data indicate that micro RNAs (miRNA) play an important role in the pathogenesis of cancer. This study aims to elucidate the role of miR-193b in the tumor tolerance of LC. High levels of miR-193b were detected in LC cells as well as in the culture supernatant. Interleukin (IL)-10-expressing Mos were detected in the LC tissue-derived single cells. Treating naïve Mos with a miR-193b induced expression of IL-10 in the Mos. Culturing the IL-10(+) Mos with effector CD8(+) T cells resulted in the suppression of CD8(+) T-cell activities.
authors.affiliation: Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China,1.
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.forename: Yuntong
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunming
authors.initials: C
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wen
authors.forename: Hui
authors.initials: H
authors.lastname: Huangfu
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism / Q000473:pathology
chemical_list: C546818:MIRN193 microRNA, human; D035683:MicroRNAs; D016753:Interleukin-10
keywords: CD8+ T cell; Immune regulation; LC; Micro RNA; Monocyte