title: Therapeutic doses of SkQ1 do not induce cytochromes P450 in rat liver.
abstract: The effect of SkQ1 (a mitochondria-targeted antioxidant) on the level of cytochromes P450 in rat liver was studied. It was found that administration of therapeutic dose of SkQ1 with drinking water for 5 days (250 nmol/kg of body weight per day) did not alter the level of cytochromes P450. Under the same conditions, the standard dose of phenobarbital used for the induction of cytochromes P450 caused the 2.7-fold increase in the content of these cytochromes. We conclude that therapeutic doses of SkQ1 do not induce cytochromes P450 in rats.
authors.affiliation: Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, 119991, Russia. skulach@belozersky.msu.ru.
authors.forename: K N
authors.initials: KN
authors.lastname: Myasoedova
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D065695:Cytochrome P-450 CYP2B6 Inducers / Q000008:administration & dosage; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D065695:Cytochrome P-450 CYP2B6 Inducers; D003577:Cytochrome P-450 Enzyme System; D010971:Plastoquinone; D010634:Phenobarbital