title: NEDD4: The founding member of a family of ubiquitin-protein ligases.
abstract: Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the patho-physiological significance of this important ubiquitin ligase.
authors.affiliation: Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia.
authors.forename: Natasha Anne
authors.initials: NA
authors.lastname: Boase
authors.affiliation: Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: sharad.kumar@health.sa.gov.au.
authors.forename: Sharad
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D056827:Endosomal Sorting Complexes Required for Transport / Q000502:physiology*; D006801:Humans; D000075702:Nedd4 Ubiquitin Protein Ligases; D009369:Neoplasms / Q000201:enzymology; D018384:Oxidative Stress; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*; D057149:Ubiquitinated Proteins / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D057149:Ubiquitinated Proteins; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618483:Nedd4 protein, human; D044767:Ubiquitin-Protein Ligases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: IGF signalling; NEDD4 family; PTEN; Ubiquitin; Ubiquitin protein ligases