title: Primary central nervous system lymphoma in Miyazaki, southwestern Japan, a human T-lymphotropic virus Type-1 (HTLV-1)-endemic area: clinicopathological review of 31 cases.
abstract: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive brain tumor. The aim of this study was to clarify the prevalence of T-cell-type PCNSL (T-PCNSL) in a human T-lymphotropic virus type-1 (HTLV-1)-endemic area of Southwestern Japan. We retrospectively investigated 31 PCNSL cases diagnosed between 1996 and 2013 at the University of Miyazaki Hospital. These cases accounted for 4.4% of all nodal or extranodal malignant lymphomas. Histologically, most of these cases were diagnosed as diffuse large B-cell lymphoma, while only two cases were considered to be low-grade and high-grade B-cell lymphoma (not otherwise specified). No T-PCNSL was found in this series. In addition, Epstein-Barr virus-encoded RNAs were not detected by in situ hybridization in any of the cases. Overall, no T-PCNSL cases were found in 18 years in a region with a high frequency of HTLV-1 seropositivity, namely, Southwestern Japan. This suggests that PCNSL and lymphomas of other anatomical sites are biologically distinct.
authors.affiliation: Department of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki Hospital.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Maekawa
authors.forename: Sayaka
authors.initials: S
authors.lastname: Moriguchi-Goto
authors.forename: Ayako
authors.initials: A
authors.lastname: Kamiunten
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kubuki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimoda
authors.forename: Hideo
authors.initials: H
authors.lastname: Takeshima
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Asada
authors.forename: Kousuke
authors.initials: K
authors.lastname: Marutsuka
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D018450:Disease Progression; D019353:Endemic Diseases; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged