title: Synthesis and biological evaluation of 1,5-naphthyridines as topoisomerase I inhibitors. A new family of antiproliferative agents.
abstract: The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity against human colon cancer cells (COLO 205).
authors.forename: Concepción
authors.initials: C
authors.lastname: Alonso
authors.forename: María
authors.initials: M
authors.lastname: Fuertes
authors.forename: María
authors.initials: M
authors.lastname: González
authors.forename: Alicia
authors.initials: A
authors.lastname: Rodríguez-Gascón
authors.forename: Gloria
authors.initials: G
authors.lastname: Rubiales
authors.affiliation: Departamento de Quimica Organica I and Centro de Investigacion Lascaray (Lascaray Research Center), Facultad de Farmacia, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria- Gasteiz, Spain. francisco.palacios@ehu.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Palacios
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004264:DNA Topoisomerases, Type I / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D006801:Humans; D020128:Inhibitory Concentration 50; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I; C528909:TOP1 protein, human; D002166:Camptothecin