title: C-H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes.
abstract: The carbonylative coupling of aryl and heteroaryl bromides with polyfluoroarenes via palladium-catalyzed C-H activation is presented. This transformation proceeds efficiently at moderate reaction temperatures and does not require strong base or reactive intermediates. A near stoichiometric amount of CO is sufficient and the methodology can thus be easily expanded to include the preparation of [(13)C]-acyl labeled benzopolyfluorophenones.
authors.affiliation: Carbon Dioxide Activation Centre (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark. ts@chem.au.dk.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Lian
authors.forename: Stig D
authors.initials: SD
authors.lastname: Friis
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D005464:Fluorobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D005464:Fluorobenzenes; D010165:Palladium; D002248:Carbon Monoxide