title: [Antithrombotic therapy after X-ray endovascular treatment: are there specific features in patients with diabetes mellitus?].
abstract: According to the current guidelines for the intervention treatment of patients with coronary heart disease, the primary and secondary prevention of cardiovascular events is long-termpharmacotherapy with platelet function inhibitors. Although undeniable progress has been made in the use of this group of medicaments, there are, however, issues calling for further investigation in the population of diabetic patients in particular. Along with the general principles of thrombosis, there are mechanisms that cause additional platelet hyperactivity in the presence of insulin deficiency and insulin resistance, metabolic and cellular disorders induced by hyperglycemia. The risk of resistance to standard antithrombotic therapy suggests a search for alternative ways to inhibit platelet aggregation, which is particularly relevant in diabetic patients.
authors.forename: I Z
authors.initials: IZ
authors.lastname: Bondarenko
authors.forename: I A
authors.initials: IA
authors.lastname: Shirshina
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kalashnikov
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy / Q000628:therapy*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D057510:Endovascular Procedures / Q000706:statistics & numerical data*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans
chemical_list: D005343:Fibrinolytic Agents