title: Molecular targets for anti-oxidative protection of green tea polyphenols against myocardial ischemic injury.
abstract: Ischemic heart disease is the leading cause of death worldwide. An improved understanding of the mechanisms involved in myocardial injury would allow intervention downstream in the pathway where certain drugs including natural products could be efficiently applied to target the end effectors of the cell death pathway. Green tea polyphenols (GTPs) have potent anti-oxidative capabilities, which may account for their beneficial effects in preventing oxidative stress associated with ischemia injury. Although studies have provided convincing evidence to support the protective effects of GTPs in cardiovascular system, the potential end effectors that mediate cardiac protection are only beginning to be addressed. Proteomics analyses widely used to identify the protein targets for many cardiovascular diseases have advanced the discovery of the signaling mechanism for GTPs-mediated cardio-protection. This review focuses on putative triggers, mediators, and end effectors for the GTPs-mediated cardio-protection signaling pathways engaged in myocardial ischemia crisis, allowing a promising natural product to be used for ameliorating oxidative stress associated with ischemic heart diseases.
authors.affiliation: Department of Cardiovascular Surgery, Taichung Veterans General Hospital, 407 Taichung, Taiwan.
authors.forename: Shih-Rong
authors.initials: SR
authors.lastname: Hsieh
authors.affiliation: Institute of Bioinformatics and Structural Biology, National Tsing Hua University, 300 Hsinchu, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Cheng
authors.affiliation: Department of Life Sciences, National Chung-Hsing University, 402 No. 250, Kuokang Road, Taichung, Taiwan.
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Su
authors.affiliation: Department of Life Sciences, National Chung-Hsing University, 402 No. 250, Kuokang Road, Taichung, Taiwan.
authors.forename: Chun-Hwei
authors.initials: CH
authors.lastname: Chiu
authors.affiliation: Department of Life Sciences, National Chung-Hsing University, 402 No. 250, Kuokang Road, Taichung, Taiwan ; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, 402 Taichung, Taiwan.
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Liou
keywords: Cardio-protection; Green tea polyphenols (GTPs); Ischemic heart disease; Oxidative stress; Proteomics