title: Briarane diterpenoids from the gorgonian Dichotella gemmacea.
abstract: Seven new briarane diterpenoids, gemmacolides AS-AY (1-7), were isolated together with ten known analogues (8-17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells.
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. lmp12@163.com.
authors.forename: Ming-Ping
authors.initials: MP
authors.lastname: La
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. lijiao_2012@126.com.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. licuiwan@163.com.
authors.forename: Cui
authors.initials: C
authors.lastname: Li
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. tanghua0309@126.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. liubaoshu@126.com.
authors.forename: Bao-Shu
authors.initials: BS
authors.lastname: Liu
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. sunpeng78@126.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. zclnathan@163.com.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Zhuang
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. ltj204@163.com.
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Li
authors.affiliation: Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. wenzhang1968@163.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D013057:Spectrum Analysis
chemical_list: D004224:Diterpenes