title: Antigenic Variation in H5N1 clade 2.1 Viruses in Indonesia From 2005 to 2011.
abstract: Influenza A (H5N1) virus, has spread to several countries in the world and has a high mortality rate. Meanwhile, the virus has evolved into several clades. The human influenza A (H5N1) virus circulating in Indonesia is a member of clade 2.1, which is different in antigenicity from other clades of influenza A (H5N1). An analysis of the antigenic variation in the H5 hemagglutinin gene (HA) of the influenza A (H5N1) virus strains circulating in Indonesia has been undertaken. Several position of amino acid mutations, including mutations at positions 35, 53, 141, 145, 163, 174, 183, 184, 189, and 231, have been identified. The mutation Val-174-Iso appears to play an important role in immunogenicity and cross-reactivity with rabbit antisera. This study shows that the evolution of the H5HA antigenic variation of the influenza A (H5N1) virus circulating in Indonesia from 2005 to 2011 may affect the immunogenicity of the virus.
authors.affiliation: Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health. ; Doctoral Program of Faculty of Medicine, University of Indonesia.
authors.forename: Vivi
authors.initials: V
authors.lastname: Setiawaty
authors.affiliation: Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health.
authors.forename: Eka
authors.initials: E
authors.lastname: Pratiwi
authors.affiliation: Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health.
authors.forename: Hana A
authors.initials: HA
authors.lastname: Pawestri
authors.affiliation: Department of Microbiology, Faculty of Medicine, University of Indonesia.
authors.forename: Fera
authors.initials: F
authors.lastname: Ibrahim
authors.affiliation: Department of Microbiology, Faculty of Medicine, University of Indonesia.
authors.forename: Amin
authors.initials: A
authors.lastname: Soebandrio
keywords: Antibody; Antigenic; Cross-reactivity; H5N1