title: A meta-analysis of IL-13 polymorphisms and pediatric asthma risk.
abstract: BACKGROUND
  IL13-1112C/T and +2044A/G polymorphisms have been reported to be correlated with pediatric asthma susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted.
  
  
  METHODS
  PubMed and EMBASE databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model.
  
  
  RESULTS
  Fourteen case-control studies with 4710 asthma cases and 6086 controls were included in this meta-analysis. IL13-1112C/T and +2044A/G polymorphisms were significantly associated with an increased risk of pediatric asthma (OR=1.14, 95% CI 1.01-1.28, P=0.04, I2=0%; OR=1.20, 95% CI 1.09-1.32, P<0.01, I2=0%), respectively. In the subgroup analysis by ethnicity, IL13-1112C/T polymorphism was significantly associated with pediatric asthma risk in whites (OR=1.29, 95% CI 1.02-1.63, P=0.03, I2=16%). IL13 +2044A/G polymorphism was significantly associated with pediatric asthma risk in Asians (OR=1.21, 95% CI 1.10-1.34, P<0.01, I2=24%).
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that IL13-1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma.
authors.affiliation: Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Peijie
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Jinrong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Qing
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
authors.affiliation: Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Bo
authors.initials: B
authors.lastname: Han
mesh_terms: D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018793:Interleukin-13