title: Prognostic factors for surgically resected squamous cell carcinoma of the lower oral cavity.
abstract: OBJECTIVE
  The objective of this study was to evaluate the impact of clinical variables on survival rates in patients with squamous cell carcinomas in the lower oral cavity.
  
  
  METHODS
  We conducted a retrospective study of patients who exhibited a histological diagnosis of squamous cell carcinoma of the lower oral cavity, who underwent surgery. Data on clinical, histological, and treatment variables were collected to assess the effect of these variables on global survival and disease-free curves.
  
  
  RESULTS
  We studied 117 patients, 86 (73.5%) males and 31 (26.5%) females, who underwent surgery between January 2005 and June 2009. The overall survival rate was 74.4% after two years, and the disease-free rate was 67.5%. Midline invasion by the primary tumor negatively impacted overall survival (P=0.02) and disease-free survival (P=0.01). The disease-free survival rate of patients with histologically confirmed neck metastases was 76.8% versus 59% for patients without metastases (P=0.01). Disease-free survival of patients with one affected lymph node was 89.5%, and 45.2% for more than one affected lymph node (P<0.01). Patients who ended radiotherapy in less than 60 days exhibited a disease-free rate of 59.0%, and patients whose treatment lasted more than 60 days exhibited a rate of 77.1% (P=0.06).
  
  
  CONCLUSIONS
  In our study, primary tumor invasion of the midline, the presence of more than one affected lymph node as confirmed by histology, the delaying radiotherapy for more than 56 days and radiotherapy that lasted longer than 60 days worsen patient prognosis.
authors.affiliation: Head and Neck Surgery Department General Hospital of São João de Deus Divinopolis, MG, Brazil.
authors.forename: J M
authors.initials: JM
authors.lastname: Soares
authors.forename: H R
authors.initials: HR
authors.lastname: Cançado
authors.forename: A A
authors.initials: AA
authors.lastname: Sousa
authors.forename: G M
authors.initials: GM
authors.lastname: Moraes
authors.forename: J R
authors.initials: JR
authors.lastname: Carvalho
authors.forename: G S
authors.initials: GS
authors.lastname: Silva
authors.forename: J M
authors.initials: JM
authors.lastname: Porcaro-Salles
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate