title: α-Glucosidase inhibitors from the leaves of Embelia ribes.
abstract: A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on a β-carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2-3, 5-15). Their structures were elucidated on the basis of spectroscopic data. Compounds 1, and 5-12 possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 1.3 to 155.0 μM, than that of a positive control acarbose (IC50, 214.5 μM).
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Phu Hoang
authors.initials: PH
authors.lastname: Dang
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Luan Bao
authors.initials: LB
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Tho Huu
authors.initials: TH
authors.lastname: Le
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
authors.forename: Truong Nhat Van
authors.initials: TN
authors.lastname: Do
authors.affiliation: Vietnam Military Medical University, Vietnam.
authors.forename: Mao Van
authors.initials: MV
authors.lastname: Can
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam. Electronic address: nttmai@hcmus.edu.vn.
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
mesh_terms: D002518:Ceramides / Q000737:chemistry* / Q000302:isolation & purification; D031645:Embelia / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D002518:Ceramides; D065089:Glycoside Hydrolase Inhibitors; C000597812:embelamide
keywords: 1,4-Dehydrated ceramide; Acarbose (PubChem CID: 444254); Carbon disulfide (PubChem CID: 6348); Dimethyl disulfide (PubChem CID: 12232); Dimethyl sulfoxide (PubChem CID: 679); Embelia ribes; Iodine (PubChem CID: 807); p-Nitrophenyl-α-d-glucopyranoside (PubChem CID: 92969); α-Glucosidase inhibition; β-Carboline