title: Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia.
abstract: Although the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post-puncture headache, drug-induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7-year-old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature.
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
authors.forename: Jong Hyung
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
authors.forename: Hyeon Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
authors.forename: Meong Hi
authors.initials: MH
authors.lastname: Son
authors.affiliation: Department of Neurology, National Cancer Center, Goyang, South Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Neurology, National Cancer Center, Goyang, South Korea.
authors.forename: Woojun
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Neurology, National Cancer Center, Goyang, South Korea.
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, National Cancer Center, Goyang, South Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
authors.forename: Byung-Kiu
authors.initials: BK
authors.lastname: Park
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000209:etiology*; D002648:Child; D003561:Cytarabine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D020301:Vasospasm, Intracranial / Q000209:etiology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine
keywords: acute lymphoblastic leukemia; cerebral vasospasm; intrathecal cytarabine