title: Science to practice: can decreased lymph node MR imaging signal intensity be used as a biomarker for the efficacy of cancer vaccination?
abstract: Summary In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Cellular Imaging Section, Institute for Cell Engineering The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor Baltimore, MD 21205.
authors.forename: Jeff W M
authors.initials: JW
authors.lastname: Bulte
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology*; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000473:pathology*
chemical_list: D000941:Antigens