title: Açai berry extract attenuates glycerol-induced acute renal failure in rats.
abstract: Acute renal failure (ARF) is one of the most common problems encountered in hospitalized critically ill patients. In recent years great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of ARF. Hence, the current study was designed to investigate the effect of Açai berry extract (ABE) on glycerol-induced ARF in rats. Results of the present study showed that rat groups that received oral ABE in a dose of 100 and 200 mg/kg/day for 7 days before or 7 days after induction of ARF by a single intramuscular glycerol injection reported a significant improvement in kidney functions tests [decrease in serum urea, serum creatinine, and blood urea nitrogen (BUN)] when compared to the ARF model groups. Moreover, there was significant amelioration in renal oxidative stress markers [renal catalase (CAT), renal reduced glutathione (GSH)] and renal histopathological changes in the ABE-treated groups when compared to ARF model groups. The most significant improvement was reported in the groups where ABE was administered in a dose 200 mg/kg/day. These results indicate that ABE has a potential role in ameliorating renal damage involved in ARF.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Alexandria University , Egypt and.
authors.forename: Amina
authors.initials: A
authors.lastname: Unis
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D065748:Euterpe; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014508:Urea / Q000097:blood
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D014508:Urea; D003404:Creatinine
keywords: Açai berry extract; acute renal failure; blood urea nitrogen; catalase; creatinine; glycerol; reduced glutathione