title: Estrogen and androgen receptors in inflammatory fibroid polyp (Vanek's tumor): case report.
abstract: OBJECTIVE
  Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with inflammatory infiltrate. The aim of the present study was to investigate the presence of estrogen and androgen receptors in IFP and compare it with its proliferative loci.
  
  
  METHODS
  The study analyzed a 79-year-old patient suffering from IFP. Analyses were performed by immunohistochemistry.
  
  
  RESULTS
  Androgen-positive spindle cells were detected at the periphery of onion skin-like formations. Estrogen receptor-positive cells were not detected and Ki67 showed low proliferative activity.
  
  
  CONCLUSIONS
  This case report shows for the first time the presence of androgen receptor-positive cells whose location corresponds with the distribution of Ki67-positive cells in IFP.
authors.affiliation: General Hospital "Nova Gradiska", Nova Gradiska, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Jukic
authors.affiliation: Children's Hospital "Srebrnjak", Zagreb, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Ferencic
authors.affiliation: Clinical Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.
authors.forename: Petra
authors.initials: P
authors.lastname: Radulovic
authors.affiliation: Clinical Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.
authors.forename: August
authors.initials: A
authors.lastname: Mijic
authors.affiliation: Institute for Medical Research and Occupational Health, Zagreb, Croatia afucic@imi.hr.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Fucic
mesh_terms: D000368:Aged; D005350:Fibroma / Q000378:metabolism* / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; D011944:Receptors, Androgen; D011960:Receptors, Estrogen
keywords: Vanek's tumor; androgen receptor; estrogen receptor; inflammatory fibroid polyp