title: Increased interventricular septum wall thickness predicts all-cause death in patients with coronary artery disease.
abstract: BACKGROUND
  There is debate regarding the predictive value of interventricular septum (IVS) wall thickness for adverse events.
  
  
  OBJECTIVE
  The study investigated the association between the severity of thickened IVS and all-cause death in Chinese patients with coronary artery disease (CAD).
  
  
  METHODS
  A total of 2297 CAD patients verified by angiography was consecutively included. Patients were grouped according to the severity of thickened IVS. Cox regression analysis was conducted to determine the independent prognostic value of thickened IVS for all-cause death.
  
  
  RESULTS
  During a median follow up of 25 months, 149 patients died. A gradient increase in the risk of death was observed across thickened IVS groups. Compared to patients with normal IVS thickness, the adjusted hazard ratio (HR) was 1.49 (95% confidence interval (CI) 1.00-2.23, P = 0.05) and 2.13 (95% CI 1.29-3.54, P = 0.003) for all-cause death in those with mildly and moderately/severely thickened IVS respectively. For one unit increase in IVS thickness, the risk of all-cause death was elevated by 14% (adjusted HR 1.14, 95% CI 1.05-1.24, P = 0.003). In patients with normal indexed left ventricular mass, thickened IVS was also demonstrated as an independent risk factor for all-cause death.
  
  
  CONCLUSIONS
  Thickened IVS can be served as a reliable marker for predicting all-cause death in Chinese patients with CAD, even in those with normal left ventricular mass.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: B-T
authors.initials: BT
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: F-Y
authors.initials: FY
authors.lastname: Huang
authors.forename: P-J
authors.initials: PJ
authors.lastname: Wang
authors.forename: Z-L
authors.initials: ZL
authors.lastname: Zuo
authors.forename: Y-B
authors.initials: YB
authors.lastname: Liao
authors.forename: H
authors.initials: H
authors.lastname: Chai
authors.forename: K-S
authors.initials: KS
authors.lastname: Huang
authors.forename: D-J
authors.initials: DJ
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D000368:Aged; D002423:Cause of Death / Q000639:trends; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011859:Radiography; D054088:Ventricular Septum / Q000000981:diagnostic imaging*
keywords: coronary artery disease; left ventricular hypertrophy; left ventricular remoulding; outcome; septal wall thickness