title: [Osteoporosis correction in experiment].
abstract: Osteoporosis is simulated in rats by chronic administration of omeprazole or serotonin for 6 months; investigated bone status in the model of liver fibrosis and the administration of serotonin against liver fibrosis. The following experimental groups of rats: with bilateral ovariectomy, with bilateral ovariectomy and administration of omeprazole, with the introduction of serotonin, with serotonin administration and bilateral ovariectomy, with model of liver fibrosis, with liver fibrosis model and administration of serotonin were used. The content of Ca, P, alkaline phosphatase, albumin, serum creatinine, and the content of Ca, P, Mg andFe in the bone was determined. It was found that the administration of mesenchymal stromal cells reduces the severity of osteoporosis. The effects of alfacalcidol on experimental osteoporosis was investigated. Introduction of alfacalcidol in all experimental groups increased the bone formation.
authors.forename: A M
authors.initials: AM
authors.lastname: Puzikov
mesh_terms: D064591:Allografts; D000818:Animals; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000494:pharmacology; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008103:Liver Cirrhosis / Q000097:blood / Q000139:chemically induced / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D008670:Metals / Q000097:blood; D009853:Omeprazole / Q000009:adverse effects / Q000494:pharmacology; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D010052:Ovariectomy; D010758:Phosphorus / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000009:adverse effects / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D050071:Bone Density Conservation Agents; D006887:Hydroxycholecalciferols; D008670:Metals; D017366:Serotonin Receptor Agonists; D010758:Phosphorus; D012701:Serotonin; D009853:Omeprazole; C008088:alfacalcidol