title: Cyr61 promotes growth of glioblastoma in vitro and in vivo.
abstract: The molecular regulation of the growth of glioblastoma (GBM) is not completely understood. Here, we show that the Cyr61 levels were significantly higher in GBM than in the adjacent non-tumor tissues. Overexpression of Cyr61 enhanced the viability of GBM cells, while inhibition of Cyr61 decreased the viability of GBM cells, in vitro and in vivo. Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling pathway to increase cell growth in GBM cells. Taken together, our findings suggest a potential role of Cyr61 in GBM growth and highlight Cyr61 as a novel target for GBM therapy.
authors.affiliation: Neurosurgery Institute, Navy General Hospital of PLA, Beijing, 100048, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Hangyu
authors.initials: H
authors.lastname: Zhang
authors.forename: Leiming
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D055515:Cysteine-Rich Protein 61 / Q000096:biosynthesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D051379:Mice
chemical_list: C501848:CCN1 protein, human; D055515:Cysteine-Rich Protein 61