title: [Migration rate of rabbit bone marrow stromal cells and rabbit dermal fibroblasts in different gels and activity of their MMPs].
abstract: This paper presents the results of the study of rabbit bone marrow stromal cells (BMSC) and rabbit dermal fibroblasts (DF) migration rates to collagen type I and fibrin gels. It has been shown that DF exhibit greater migration activity in collagen gel, whereas BMSC show a higher migration activity in fibrin gels. By studying the activity of matrix metalloproteinases (MMPs) synthesized by cells during cultivation in gels, it has been found for both cell types that the activity of MMP-9 is increased in fibrin gels and activity of MMP-2 is increased in collagen gels. Different speed of the migration of cells may be due to the properties of the cells, the activity of MMP synthesized by the cells and the influence of the microenvironment (collagen or fibrin) on the process of synthesis.
authors.forename: N M
authors.initials: NM
authors.lastname: Iudintseva
authors.forename: N S
authors.initials: NS
authors.lastname: Nikolaenko
authors.forename: I V
authors.initials: IV
authors.lastname: Voronkina
authors.forename: L V
authors.initials: LV
authors.lastname: Smagina
authors.forename: G P
authors.initials: GP
authors.lastname: Pinaev
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects; D024042:Collagen Type I / Q000737:chemistry / Q000494:pharmacology*; D020405:Dermis / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D005337:Fibrin / Q000737:chemistry / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D005782:Gels; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009928:Organ Specificity; D061251:Primary Cell Culture; D011817:Rabbits; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
chemical_list: D024042:Collagen Type I; D005782:Gels; D005337:Fibrin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9