title: Accelerating progress towards tuberculosis elimination: the need for combination treatment and prevention.
abstract: Although estimated tuberculosis (TB) incidence is now falling globally, we are unlikely to achieve the Millennium Development Goal (MDG) TB targets without changing the emphasis of the global TB response in high human immunodeficiency virus prevalence settings. Two independent modelling exercises using South African data with different structures and assumptions conclude that, until new drugs, diagnostics and vaccines are available, a fully funded and accessible combination approach to anti-tuberculosis treatment and prevention, based on knowledge of local TB epidemiology and evidence-informed policy, is essential to accelerate progress towards zero new tuberculous infections, zero TB deaths and zero suffering from TB.
authors.affiliation: Joint United Nations Programme on HIV/AIDS Country Office, Pretoria, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: Reid
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Grant
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: White
authors.affiliation: World Health Organization, Geneva, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Dye
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK; Public Health England, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Vynnycky
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Fielding
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK; The Aurum Institute, Johannesburg, South Africa; School of Public Health, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: G
authors.initials: G
authors.lastname: Churchyard
authors.affiliation: National Department of Health, Pretoria, South Africa.
authors.forename: Y
authors.initials: Y
authors.lastname: Pillay
mesh_terms: D044966:Anti-Retroviral Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D016000:Cluster Analysis; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008962:Models, Theoretical; D015995:Prevalence; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents