title: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD.
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. r.hukema@erasmusmc.nl.|, PO Box 2040, , 3000 CA, Rotterdam, The Netherlands. r.hukema@erasmusmc.nl.
authors.forename: Renate K
authors.initials: RK
authors.lastname: Hukema
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. f.w.riemslagh@erasmusmc.nl.|Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. f.w.riemslagh@erasmusmc.nl.
authors.forename: Fréderike W
authors.initials: FW
authors.lastname: Riemslagh
authors.affiliation: Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. s.melhem@erasmusmc.nl.
authors.forename: Shamiram
authors.initials: S
authors.lastname: Melhem
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. h.vanderlinde@erasmusmc.nl.
authors.forename: Herma C
authors.initials: HC
authors.lastname: van der Linde
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. e.severijnen@erasmusmc.nl.
authors.forename: Lies-Anne Wfm
authors.initials: LA
authors.lastname: Severijnen
authors.affiliation: German Center for Neurodegenerative Diseases, 81337, Munich, Germany. dieter.edbauer@med.uni-muenchen.de.
authors.forename: Dieter
authors.initials: D
authors.lastname: Edbauer
authors.affiliation: Department of Cell Biology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. a.maas.1@erasmusmc.nl.
authors.forename: Alex
authors.initials: A
authors.lastname: Maas
authors.affiliation: Department of Neurobiology and Genetics, IGBMC, INSERM U964, CNRS UMR7104, University of Strasbourg, Illkirch, France. ncharlet@igbmc.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charlet-Berguerand
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. r.willemsen@erasmusmc.nl.
authors.forename: Rob
authors.initials: R
authors.lastname: Willemsen
authors.affiliation: Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. j.c.vanswieten@erasmusmc.nl.|Department of Neurology, Neuroscience Campus Amsterdam, 1007 MB, Amsterdam, The Netherlands. j.c.vanswieten@erasmusmc.nl.
authors.forename: John C
authors.initials: JC
authors.lastname: van Swieten
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D000073885:C9orf72 Protein; D042622:DNA Repeat Expansion; D004195:Disease Models, Animal; D057180:Frontotemporal Dementia / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism; D008822:Mice, Transgenic; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins; D025801:Ubiquitin