title: Acute viral hepatitis E presenting with haemolytic anaemia and acute renal failure in a patient with glucose-6-phosphate dehydrogenase deficiency.
abstract: The association of acute hepatitis E viral (HEV) infection with glucose-6-phosphate dehydrogenase (G6PD) deficiency leading to extensive intravascular haemolysis is a very rare clinical entity. Here we discuss such a patient, who presented with acute HEV illness, developed severe intravascular haemolysis and unusually high levels of bilirubin, complicated by acute renal failure (ARF), and was later on found to have a deficiency of G6PD. The patient recovered completely with haemodialysis and supportive management.
authors.affiliation: Senior Resident, Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital (UCMS & GTBH), University of Delhi, Delhi, India drlaxmikantucms@yahoo.com.
authors.forename: Laxmikant Ramkumarsingh
authors.initials: LR
authors.lastname: Tomar
authors.affiliation: Assistant Professor, Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital (UCMS & GTBH); University of Delhi, Delhi, India.
authors.forename: Amitesh
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Assistant Professor, Department of Medicine, PGIMER; Physician, RML Hospital, New Delhi, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Jain
authors.affiliation: Specialist, Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital (UCMS & GTBH), University of Delhi, Delhi, India.
authors.forename: Surender
authors.initials: S
authors.lastname: Rajpal
authors.affiliation: Professor, Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital (UCMS & GTBH), University of Delhi, Delhi, India.
authors.forename: Mukul P
authors.initials: MP
authors.lastname: Agarwal
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000743:Anemia, Hemolytic / Q000209:etiology*; D019468:Disease Management; D005954:Glucosephosphate Dehydrogenase; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D016751:Hepatitis E / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D016752:Hepatitis E virus / Q000302:isolation & purification; D006801:Humans; D008297:Male
chemical_list: D005954:Glucosephosphate Dehydrogenase
keywords: Acute kidney injury; G6PD; Hepatitis