title: Synthesis of 2-amino-1,3,4-oxadiazoles and 2-amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C–O/C–S bond formation.
abstract: 2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Niu
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Kang
authors.forename: Xianhai
authors.initials: X
authors.lastname: Tian
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.forename: Hongxu
authors.initials: H
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Wenquan
authors.initials: W
authors.lastname: Yu
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
mesh_terms: D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012663:Semicarbazides / Q000737:chemistry*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C583345:2-amino-1,3,4-oxadiazole; D010069:Oxadiazoles; D012663:Semicarbazides; D013830:Thiadiazoles; C005151:thiosemicarbazide; C010852:2-amino-1,3,4-thiadiazole