title: Enhancing fluorescence in vivo imaging using inorganic nanoprobes.
abstract: Fluorescence imaging is a versatile tool for biological and preclinical studies with steady improvements in performance thanks to instrumentation and probe developments. The sensitive detection and imaging of deep targets in vivo is especially challenging due to the diffusion and absorption of light by the tissues and to the emission of autofluorescence from intrinsic chromophores. Fluorescent inorganic nanoparticles present interesting optical properties that may significantly differ from organic dyes. In this short review, we present recent developments in the design of these nanoprobes and their use for new in vivo fluorescence modalities which provide enhanced imaging capabilities.
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouccara
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Sitbon
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Fragola
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Loriette
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Lequeux
authors.affiliation: LPEM, PSL Research University, ESPCI-ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, France; CNRS, UMR 8213, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France. Electronic address: thomas.pons@espci.fr.
authors.forename: T
authors.initials: T
authors.lastname: Pons
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D064847:Multimodal Imaging; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes