title: Late isolated central nervous system relapse from ovarian serous adenocarcinoma: a case report and literature review.
abstract: Central nervous system involvement by ovarian serous adenocarcinoma is rare. We report a case of a 60-year-old woman that developed brain metastasis as isolated site of relapse 4.5 years after a complete resection and adjuvant chemotherapy for a stage Ic disease. She proceeded to a craniotomy with resection of the lesion and, subsequently, to a whole brain radiotherapy. Nineteen months later, she developed carcinomatous meningitis as isolated site of recurrence. Patient was submitted to intrathecal chemotherapy with methotrexate; however, she died from progressive neurologic involvement disease few weeks later.
authors.affiliation: Department of Medical Oncology, Instituto do Cancer do Estado de Sao Paulo, 251 Doutor Arnaldo Avenue, 01246-000 Sao Paulo, SP, Brazil.
authors.forename: Tiago Biachi
authors.initials: TB
authors.lastname: de Castria
authors.affiliation: Faculdade de Medicina, Universidade de Sao Paulo, 455 Doutor Arnaldo Avenue, 01246-000 Sao Paulo, SP, Brazil.
authors.forename: Sylvia Regina Quintanilha
authors.initials: SR
authors.lastname: Rodrigues
authors.affiliation: Department of Medical Oncology, Instituto do Cancer do Estado de Sao Paulo, 251 Doutor Arnaldo Avenue, 01246-000 Sao Paulo, SP, Brazil.
authors.forename: Maria Del Pilar Estevez
authors.initials: Mdel P
authors.lastname: Diz