title: [Primary hepatic angiosarcoma: A retrospective analysis of eight cases].
abstract: Angiosarcoma is a malignant tumor of vascular endothelial cell origin. Primary hepatic angiosarcoma is rare, most often associated with chronic exposure to toxic substances. The diagnosis of angiosarcoma is based on histological examination. Presenting symptoms are nonspecific, including abdominal pain, impaired general condition and fever. Primary hepatic angiosarcoma is a fast-growing tumor and the diagnosis is usually made at an advanced stage of the disease. The prognosis is poor. Surgical resection is recommended as the curative choice in localized forms, highlighting the key role of screening programs of occupational medicine that may help to diagnose tumors at an earlier, localized stage. Radiotherapy and chemotherapy are considered to have a limited efficacy. Here, we report a series of eight cases of primary hepatic angiosarcoma diagnosed at the University Hospital of Besançon between 2001 and 2012. Clinical, radiological, histological and therapeutic characteristics of the patients are described and analyzed.
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Arnault
authors.initials: A
authors.lastname: Cazorla
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Félix
authors.affiliation: Service de radiologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Delabrousse
authors.affiliation: Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France; EA3181, SFR4234, université de Franche-Comté, 25000 Besançon, France. Electronic address: svalmary@univ-fcomte.fr.
authors.forename: Séverine
authors.initials: S
authors.lastname: Valmary-Degano
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D006394:Hemangiosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D014752:Vinyl Chloride / Q000633:toxicity
chemical_list: D000964:Antimetabolites, Antineoplastic; D004317:Doxorubicin; D014752:Vinyl Chloride
keywords: Angiosarcoma; Angiosarcome; Exposition toxique; Exposure to toxic substances; Localisation hépatique; Primary hepatic location; Survie; Survival