title: Granulomatosis with polyangiitis and constrictive pericarditis--a case report.
abstract: Polyangiitis with granulomatosis, previously known as Wegener's granulomatosis, is a systemic necrotising granulomatous vasculitis. It predominantly affects the upper and lower respiratory tracts and the kidneys, but can potentially affect any organ system. It is diagnosed by clinical features, immunology (anti-neutrophil cytoplasmic antibodies) and histology. Cardiac involvement occurs in 6 to 44% of cases. We present a case of polyangiitis with granulomatosis and constrictive pericarditis, which occurred despite vigorous immunosuppression and which required surgical pericardectomy.
authors.affiliation: AE Horne, Rheumatic Diseases Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Email annamariehorne@nhs.net.
authors.forename: A E
authors.initials: AE
authors.lastname: Horne
authors.forename: P A
authors.initials: PA
authors.lastname: Henriksen
authors.forename: E N
authors.initials: EN
authors.lastname: Amft
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use; D004417:Dyspnea / Q000209:etiology; D015150:Echocardiography, Doppler; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D010494:Pericarditis, Constrictive / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D003078:Colchicine
keywords: GPA; Wegener's granulomatosis; breathless; pericardial constriction; pericardial stripping