title: Simultaneous pressure-volume measurements using optical sensors and MRI for left ventricle function assessment during animal experiment.
abstract: Simultaneous pressure and volume measurements enable the extraction of valuable parameters for left ventricle function assessment. Cardiac MR has proven to be the most accurate method for volume estimation. Nonetheless, measuring pressure simultaneously during MRI acquisitions remains a challenge given the magnetic nature of the widely used pressure transducers. In this study we show the feasibility of simultaneous in vivo pressure-volume acquisitions with MRI using optical pressure sensors. Pressure-volume loops were calculated while inducing three inotropic states in a sheep and functional indices were extracted, using single beat loops, to characterize systolic and diastolic performance. Functional indices evolved as expected in response to positive inotropic stimuli. The end-systolic elastance, representing the contractility index, the diastolic myocardium compliance, and the cardiac work efficiency all increased when inducing inotropic state enhancement. The association of MRI and optical pressure sensors within the left ventricle successfully enabled pressure-volume loop analysis after having respective data simultaneously recorded during the experimentation without the need to move the animal between each inotropic state.
authors.affiliation: Univ Paris-Sud, IR4M, UMR8081 Orsay, France; CNRS, IR4M, UMR8081 Orsay, France. Electronic address: dima.rodriguez@u-psud.fr.
authors.forename: Dima
authors.initials: D
authors.lastname: Abi-Abdallah Rodriguez
authors.affiliation: Univ Paris-Sud, IR4M, UMR8081 Orsay, France; CNRS, IR4M, UMR8081 Orsay, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Durand
authors.affiliation: Univ Paris-Sud, IR4M, UMR8081 Orsay, France; CNRS, IR4M, UMR8081 Orsay, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: de Rochefort
authors.affiliation: Univ Paris 05, France; Hôpital Necker-Enfants malades, AP HP, Paris, France.
authors.forename: Younes
authors.initials: Y
authors.lastname: Boudjemline
authors.affiliation: Univ Paris 05, France; INSERM, U678 Paris, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Mousseaux
mesh_terms: D000818:Animals; D001794:Blood Pressure; D057791:Cardiac Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009200:Myocardial Contraction / Q000502:physiology; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D009929:Organ Size; D011312:Pressure; D012756:Sheep; D016276:Ventricular Function / Q000502:physiology*
keywords: Cardiovascular magnetic resonance; Contractility index; Diastolic compliance; Effective arterial elastance; Optical pressure measurements; PV loop functional parameters