title: Acute eccentric resistance exercise decreases matrix metalloproteinase activity in obese elderly women.
abstract: The association of ageing with obesity commits elderly women and has been correlated with multiple degenerative processes, which could be occasioned by an enhancing in levels of matrix metalloproteinase-2 and metalloproteinase-9 (MMPs) as well by an cytokine unbalance that included an enhancing on interleukin-6 (IL-6). Furthermore, other factors could be also related to degenerative process, as they could be reduced by eccentric resistance exercise (ERE), which seems particularly important to initiate resistance training in obese older adults. In this view, this study aims to determinate the effects of an acute ERE session on serum MMP-2, MMP-9 and IL-6 in elderly obese women. Ten elderly obese women participated in this study and completed a 10 repetitions maximum test (10 RM) utilizing leg extension exercise. Subjects then completed an acute ERE session consisting of seven sets of 10 repetitions at 110% of 10 RM with a rest of 3 min between sets. Blood samples were collected before, immediately after, 3, 24 and 48 h following the ERE session. Zymograms were utilized to measure the MMP-2 and MMP-9 enzymes from all individuals. Moreover, IL-6 concentration was also determinated. After ERE session, MMP-2 and MMP-9 decreased, remaining significantly below baseline values after 48 h (P<0·05). Although not statistically significant, there was a tendency for IL-6 to decrease 48 h after the ERE when compared with 3 h (P = 0·06). An acute ERE session decreases MMP-9, MMP-2 and IL-6 in elderly obese women, possibly indicating a transient protection against the low grade inflammation present in this specific population.
authors.affiliation: Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Dahan da Cunha
authors.initials: Dda C
authors.lastname: Nascimento
authors.affiliation: Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, USA.
authors.forename: James Wilfred
authors.initials: JW
authors.lastname: Navalta
authors.affiliation: University of Brasilia, Brasilia, Brazil.
authors.forename: João Luiz Quagliotti
authors.initials: JL
authors.lastname: Durigan
authors.affiliation: University of Brasilia, Brasilia, Brazil.|Graduate Program in Health Sciences and Technologies, University of Brasilia, Brasilia, Brazil.
authors.forename: Rita de Cassia
authors.initials: Rde C
authors.lastname: Marqueti
authors.affiliation: Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.affiliation: Center for Proteomic and Biochemical Analyses, Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Octavio
authors.initials: O
authors.lastname: Luiz Franco
authors.affiliation: Center for Proteomic and Biochemical Analyses, Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasilia, Brazil.|Graduate Program in Health Sciences and Technologies, University of Brasilia, Brasilia, Brazil.
authors.forename: Jesser Alves
authors.initials: JA
authors.lastname: de Almeida
authors.affiliation: Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Nathalia Ferreira
authors.initials: NF
authors.lastname: Camarço
authors.affiliation: Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Ivo Vieira de Sousa
authors.initials: IV
authors.lastname: Neto
authors.affiliation: Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
mesh_terms: D000367:Age Factors; D000368:Aged; D015536:Down-Regulation; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000201:enzymology* / Q000503:physiopathology; D055070:Resistance Training; D012737:Sex Factors; D013997:Time Factors
chemical_list: C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: blood markers; eccentric contraction; elderly; inflammation; matrix metalloproteinases; obesity