title: Prenatal exposure to pyrethroid insecticides and birth outcomes in Rural Northern China.
abstract: Although pyrethroid insecticides are widely used, little is known about potential adverse effects on fetal growth. Participating 454 mother-infant pairs were recruited from a prospective birth cohort in rural northern China between September 2010 and 2012. We measured five non-specific pyrethroid metabolites in maternal urine at delivery and examined their association with birth outcomes including birth weight, length, head circumference, and gestational duration. The creatinine-adjusted medians of pyrethroid metabolites in urine were 0.51 μg/g for cis-DCCA, 0.65 μg/g for trans-DCCA, and 0.68 μg/g for 3-PBA. The pregnant women had substantially higher levels of urinary pyrethroid metabolites compared with those reported in developed countries. A increase in total (the sum of cis-DCCA, trans-DCCA, and 3-PBA) but not individual urinary metabolite levels was associated with a decrease in birth weight (adjusted β=-96.76 g per log10 unit increase, 95% confidence interval=-173.15 to -20.37). No associations were found between individual or total metabolite levels and birth length, head circumference, or gestational duration. We report an adverse association of prenatal exposure to pyrethroids as measured by urinary metabolites with birth weight. More studies are warranted in China given the relatively high levels of urinary metabolites in our study population.
authors.affiliation: MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Ding
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Cui
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.affiliation: 1] MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [2] Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D002681:China; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D005320:Fetal Macrosomia / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007306:Insecticides / Q000633:toxicity* / Q000652:urine; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000175:diagnosis; D011446:Prospective Studies; D011722:Pyrethrins / Q000633:toxicity* / Q000652:urine; D012423:Rural Health / Q000706:statistics & numerical data*
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D011722:Pyrethrins