title: Renal acid-base regulation: new insights from animal models.
abstract: Because majority of biological processes are dependent on pH, maintaining systemic acid-base balance is critical. The kidney contributes to systemic acid-base regulation, by reabsorbing HCO3 (-) (both filtered by glomeruli and generated within a nephron) and acidifying urine. Abnormalities in those processes will eventually lead to a disruption in systemic acid-base balance and provoke metabolic acid-base disorders. Research over the past 30 years advanced our understanding on cellular and molecular mechanisms responsible for those processes. In particular, a variety of transgenic animal models, where target genes are deleted either globally or conditionally, provided significant insights into how specific transporters are contributing to the renal acid-base regulation. Here, we broadly overview the mechanisms of renal ion transport participating to acid-base regulation, with emphasis on data obtained from transgenic mice models.
authors.affiliation: Department of Physiology, Hopital Européen Georges Pompidou, AP-HP, 56 rue Leblanc, F-75015, Paris, France, dominique.eladari@inserm.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Eladari
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kumai
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008822:Mice, Transgenic; D008954:Models, Biological; D010641:Phenotype; D065667:Renal Elimination; D065608:Renal Reabsorption; D014882:Water-Electrolyte Balance; D014883:Water-Electrolyte Imbalance / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D026901:Membrane Transport Proteins