title: Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.
abstract: Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla CA 92093-0358, USA. ytor@ucsd.edu.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Shin
authors.forename: Peter
authors.initials: P
authors.lastname: Lönn
authors.forename: Steven F
authors.initials: SF
authors.lastname: Dowdy
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Tor
mesh_terms: D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques; D006801:Humans; D015394:Molecular Structure; D009841:Oligonucleotides / Q000235:genetics* / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*
chemical_list: D009841:Oligonucleotides; D034741:RNA, Small Interfering