title: Sebaceous carcinoma: review of the literature.
abstract: BACKGROUND
  Sebaceous carcinoma is an uncommon adnexal neoplasm with a documented capability for regional and distant metastasis. Traditionally, sebaceous carcinoma has been associated with high rates of recurrence after excision.
  
  
  OBJECTIVE
  To review the current literature on sebaceous carcinoma and detail its epidemiology, pathogenesis, clinical presentation, histopathology, diagnostic workup, treatment, and prognosis.
  
  
  METHODS
  Literature review using PubMed search for articles related to sebaceous carcinoma.
  
  
  RESULTS
  Sebaceous carcinoma typically presents as a painless pink or yellow nodule. Diagnosis requires histopathologic examination, and immunohistochemical analysis often assists in the differentiation of sebaceous carcinoma from other benign and malignant skin neoplasms. Sebaceous carcinoma should prompt a workup for Muir-Torre syndrome. Periorbital sebaceous carcinoma has an increased tendency for regional metastasis, although cancer-specific mortality rates are similar among all anatomic locations.
  
  
  CONCLUSIONS
  Surgery is the preferred treatment for local disease. Limited data suggest that Mohs micrographic surgery may provide superior clinical outcomes, but more research is needed regarding the long-term outcomes. Radiation and systemic chemotherapy are reserved for recurrent or metastatic disease.
authors.affiliation: *Washington University School of Medicine, St Louis, Missouri; †Department of Internal Medicine, Division of Dermatology, Washington University, St Louis, Missouri.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Kyllo
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Brady
authors.forename: Eva A
authors.initials: EA
authors.lastname: Hurst
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D015580:Mohs Surgery; D055653:Muir-Torre Syndrome / Q000175:diagnosis; D009367:Neoplasm Staging; D011379:Prognosis; D011878:Radiotherapy; D012626:Sebaceous Gland Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D021701:Sentinel Lymph Node Biopsy
chemical_list: D000970:Antineoplastic Agents