title: Genetic variants in renalase and blood pressure responses to dietary salt and potassium interventions: a family-based association study.
abstract: OBJECTIVE
  Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between genetic variants in RNLS and blood pressure (BP) responses to strict dietary interventions of salt and potassium intake.
  
  
  METHODS
  A total of 334 subjects from 124 families were selected and sequentially maintained on a low-salt diet for 7 days (3.0 g/day, NaCl), then a high-salt diet for 7 days (18.0 g/day, NaCl), high-salt diet with potassium supplementation for another 7 days (4.5 g/day, KCl).
  
  
  RESULTS
  SNPs rs919115 and rs792205 of the RNLS gene were significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) responses to high-salt intervention. In addition, rs12356177 was significantly associated with systolic BP (SBP) and DBP responses to low-salt diet, and SBP, DBP or MAP during the high-salt intervention. Unfortunately, no associations for the 7 RNLS SNPs with BP response to high-salt diet with potassium supplementation reached nominal statistical significance.
  
  
  CONCLUSIONS
  This family-based study indicates that genetic variants in the RNLS gene are significantly associated with BP responses to dietary salt intake.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College, Xi'an Jiaotong University and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chu
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Mu
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Liu
authors.forename: Ke-Yu
authors.initials: KY
authors.lastname: Ren
authors.forename: Tong-Shuai
authors.initials: TS
authors.lastname: Guo
authors.forename: Zu-Yi
authors.initials: ZY
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D017419:Potassium, Dietary / Q000008:administration & dosage*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D017419:Potassium, Dietary; D017673:Sodium Chloride, Dietary; D008995:Monoamine Oxidase; C521557:renalase