title: Redox-neutral α-allylation of amines by combining palladium catalysis and visible-light photoredox catalysis.
abstract: An unprecedented α-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual catalysis process, the catalytic generation of allyl radical from the corresponding π-allylpalladium intermediate was achieved without additional metal reducing reagents (redox-neutral). Various allylation products of amines were obtained in high yields through radical cross-coupling under mild reaction conditions. Moreover, the transformation was applied to the formal synthesis of 8-oxoprotoberberine derivatives which show potential anticancer properties.
authors.affiliation: CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079 (China) http://chem-xiao.ccnu.edu.cn/
authors.forename: Jun
authors.initials: J
authors.lastname: Xuan
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Zeng
authors.forename: Zhu-Jia
authors.initials: ZJ
authors.lastname: Feng
authors.forename: Qiao-Hui
authors.initials: QH
authors.lastname: Deng
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
authors.forename: Howard
authors.initials: H
authors.lastname: Alper
keywords: allylic compounds; palladium; photochemistry; radicals; synthetic methods