title: Role of bone scan in the assessment of polymyositis/dermatomyositis.
abstract: The aim of this study was to determine the significance of bone scan findings in Korean polymyositis/dermatomyositis (PM/DM) patients. The participants in this study were 26 PM/DM patients who fulfilled the proposed criteria for definite or probable PM/DM. All patients had been examined by bone scan. The results were analyzed visually and quantitatively using the uptake ratios. Correlations between the bone scan parameters of six proximal muscle groups (trapezius, deltoid, biceps, iliopsoas, quadriceps, and gluteus medius and maximus) and clinical parameters (laboratory values and manual muscle test) representing disease activities were assessed. Based on visual analyses of their bone scans, 10 of 14 (71.4 %) patients with active PM/DM had abnormal muscle uptake. Visual grading of the bone scans had a sensitivity and specificity of 74 and 90.9 %, respectively, for the assessment of muscle inflammation. Maximal proximal muscle uptake ratios, as determined on the bone scans, were significantly higher in patients with active PM/DM than in those with inactive disease (median 1.97 vs. 1.02, p = 0.046). Maximal proximal uptake ratios correlated significantly with creatine kinase (r = 0.394, p = 0.046), lactate dehydrogenase (LDH, r = 0.473, p = 0.015), aldolase (r = 0.428, p = 0.029), erythrocyte sedimentation rate (r = 0.412, p = 0.036), C-reactive protein (r = 0.454, p = 0.002), and manual muscle test results (r = -0.399, p = 0.044). Mean proximal muscle uptake ratios correlated significantly with LDH (r = 0.438, p = 0.025) and aldolase (r = 0.572, p = 0.002). Visually assessed proximal muscle uptake grades and maximal proximal muscle uptake ratios as determined by bone scan correlated significantly with the levels of known PM/DM disease activity markers. The findings of this study suggest that bone scan is a useful imaging technique for the evaluation of PM/DM patients.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, South Korea.
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: An
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Suh
authors.forename: Ju-Yang
authors.initials: JY
authors.lastname: Jung
authors.forename: Hyoun-Ah
authors.initials: HA
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001799:Blood Sedimentation; D001842:Bone and Bones / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000378:metabolism; D003882:Dermatomyositis / Q000175:diagnosis*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D010710:Phosphates / Q000737:chemistry; D017285:Polymyositis / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D056910:Republic of Korea; D012680:Sensitivity and Specificity; D013667:Technetium; D055815:Young Adult
chemical_list: D010710:Phosphates; D013667:Technetium; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase