title: Association between FcεRIβ and IFN-γ Polymorphisms and Asthma in Asian Population: a Meta-Analysis.
abstract: Polymorphisms in the β subunit of the high affinity receptor for IgE (FcεRIβ) and interferon-γ (IFN-γ) genes may influence the risk of asthma. However, the results in Asian population are still debatable. We performed a meta-analysis to ascertain the association between the FcεRIβ E237G, FcεRIβ -109C/T, and IFN-γ 874T/A polymorphisms and asthma in an Asian population. Databases including PubMed, Chinese National Knowledge Infrastructure (CNKI), Weipu, and Wan Fang (Chinese) databases were searched to find the relevant studies. The effect summary odds ratio (OR) with 95% conﬁdence interval (CI) was calculated. There was no significant difference in dominant model and allele model (EG + GG vs. EE: OR = 1.14, 95%CI = 0.94-1.40; G vs. E: OR = 1.13, 95%CI = 0.95-1.34) for FcεRIβ E237G, and no significant association was observed in the subgroup analysis by age and atopic status. A significantly decreased risk of asthma was observed in allelic model (C vs. T: OR=0.88, 95%CI=0.80-0.98) for FcεRIβ -109C/T, significant association was found in dominant model (AT+TT vs. AA: OR=0.56, 95% CI=0.33-0.97) for IFN-γ 874T/A. This meta-analysis suggested that FcεRIβ E237G is not an influencing factor for asthma in Asian population. FcεRIβ -109C/T and IFN-γ 874T/A polymorphisms may be influencing factors for asthma in the Asian population.
authors.affiliation: Laboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology, Huainan 232001 China and School of Public Health, Wannan Medical College, Wuhu 241002 China. yingshuiyao@163.com.
authors.forename: Ying-Shui
authors.initials: YS
authors.lastname: Yao
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 410376220@qq.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 94017416@qq.com.
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Jin
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 1983helianping@163.com.
authors.forename: Lian-Ping
authors.initials: LP
authors.lastname: He
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 452049263@qq.com.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Chang
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 2313449765@qq.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 601517147@qq.com.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Ding
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu 241002 China. 154181498@qq.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Laboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology, Huainan 232001 China and Department of Medical Parasitology, Wannan Medical College, Wuhu, 241002 China. 13805536665@126.com.
authors.forename: Chao-Pin
authors.initials: CP
authors.lastname: Li
mesh_terms: D044466:Asian People; D001249:Asthma / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017455:Receptors, IgE / Q000235:genetics*
chemical_list: C502447:MS4A2 protein, human; D017455:Receptors, IgE; D007371:Interferon-gamma