title: Effect of continuous positive airway pressure on leptin levels in patients with obstructive sleep apnea: a meta-analysis.
abstract: OBJECTIVE
  Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea hypopnea syndrome (OSAHS), but previous studies assessing the effect of CPAP on leptin in patients with OSAHS yielded conflicting results. In this study, we conducted a meta-analysis to determine whether CPAP therapy could reduce serum leptin levels.
  
  
  METHODS
  Databases of PubMed, Elsevier, and SCI were thoroughly searched by 2 independent reviewers.
  
  
  METHODS
  RevMan (version 5.2) was used for data synthesis. Weighted mean difference (WMD) before and after CPAP therapy was calculated to estimate the effects of CPAP therapy.
  
  
  RESULTS
  A total of 11 studies involving 413 participants were included. Meta-analysis showed that the total WMD for leptin levels was 1.44 units (95% confidence interval: 1.11-1.77, P < .01) before and after CPAP therapy. Subgroup analysis exhibited that leptin was decreased within 3 days after the therapy, and it was further reduced within 1 to 3 months and beyond.
  
  
  CONCLUSIONS
  The results of our meta-analysis showed that CPAP could significantly reduce leptin levels in OSAHS patients without concomitant weight loss.
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Niu
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Epidemiology and Biostatistics and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Meixia
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China entwjkong@hust.edu.cn.
authors.forename: Weijia
authors.initials: W
authors.lastname: Kong
mesh_terms: D045422:Continuous Positive Airway Pressure; D004268:DNA-Binding Proteins; D006801:Humans; D020738:Leptin / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*; D014157:Transcription Factors; D015431:Weight Loss
chemical_list: D004268:DNA-Binding Proteins; D020738:Leptin; D014157:Transcription Factors; C075372:insulin response element binding protein, human
keywords: continuous positive airway pressure; insulin resistance; leptin; meta-analysis; obesity; obstructive sleep apnea