title: [Biochemical indices of connective tissue metabolism in patients with chronic hepatitis B and C].
abstract: 37 patients with chronic hepatitis B and C were examined. Patients were divided into 3 groups depending on the degree of connective tissue dysplasia. We investigated: free and protein-bounded hydroxyproline, collagenase activity, total alkaline phosphatase and its bone fraction, creatinine, calcium and phosphorus content in the blood serum and urine. It has been found the dependence of collagen synthesis from the state of connective tissue. The higher is the degree of dysplasia, the more intensive is the process of collagen synthesis (P < 0.05). The index of corellation between protein-bounded and free fraction can be used as a biochemical marker for determination the stage of pathological process in the liver and for monitoring the effectiveness of therapy.
authors.forename: T L
authors.initials: TL
authors.lastname: Martynovich
authors.forename: S
authors.initials: S
authors.lastname: Magomedov
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000097:blood / Q000652:urine; D003094:Collagen / Q000096:biosynthesis*; D017364:Collagenases / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology / Q000652:urine / Q000821:virology; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000473:pathology / Q000652:urine / Q000821:virology; D006801:Humans; D006909:Hydroxyproline / Q000097:blood / Q000652:urine; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D010758:Phosphorus / Q000097:blood / Q000652:urine
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D010758:Phosphorus; D003094:Collagen; D003404:Creatinine; D017364:Collagenases; D006909:Hydroxyproline; D002118:Calcium