title: Stereospecific ligands and their complexes. XXII. Synthesis and antitumor activity of palladium(II) complexes with some esters of (S,S)-ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid.
abstract: Four new ligands and their palladium(II) complexes of general formula R2-S,S-eddtyr (L1-L4) and [PdCl2(R2-S,S-eddtyr)] (C1-C4) (R=ethyl, n-propyl, n-butyl and n-pentyl; S,S-eddtyr·2HCl=ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid dihydrochloride have been synthesized and characterized by microanalysis, infrared, (1)H and (13)C NMR spectroscopy. Cytotoxicity for ligands and complexes on two different cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL) was investigated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Danijela Lj
authors.initials: DLj
authors.lastname: Stojković
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia. Electronic address: glodjovicv@yahoo.com.
authors.forename: Verica V
authors.initials: VV
authors.lastname: Jevtić
authors.affiliation: Centre for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
authors.forename: Gordana P
authors.initials: GP
authors.lastname: Radić
authors.affiliation: Centre for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
authors.forename: Danijela V
authors.initials: DV
authors.lastname: Todorović
authors.affiliation: Department of Laboratory Diagnostics, Clinical Center Kragujevac, Zmaj Jovina St. 30, 34000 Kragujevac, Serbia.
authors.forename: Marija
authors.initials: M
authors.lastname: Petrović
authors.affiliation: Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Zarić
authors.affiliation: Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Nikolić
authors.affiliation: Centre for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Baskić
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Srećko R
authors.initials: SR
authors.lastname: Trifunović
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D003603:Cytotoxins; D010165:Palladium
keywords: (1)H and (13)C NMR spectroscopy; Cytotoxicity; Infrared spectroscopy; Palladium(II) complexes