title: Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat.
abstract: BACKGROUND
  To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries.
  
  
  METHODS
  This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group). Body weight of all animals were monitored weekly.
  
  
  RESULTS
  The BPA-exposed animals exhibited disruption of their estrus cycle, while those animals treated with BPA together with Tualang honey, exhibited an improvement in percentage of normal estrous cycle. Their ovaries had lower numbers of atretic follicles compared to the PC group but higher than the CO group.
  
  
  CONCLUSIONS
  Tualang honey has a potential role in reducing BPA-induced ovarian toxicity by reducing the morphological abnormalities of the ovarian follicles and improving the normal estrous cycle.
authors.forename: Siti Sarah Mohamad
authors.initials: SS
authors.lastname: Zaid
authors.forename: Shatrah
authors.initials: S
authors.lastname: Othman
authors.affiliation: Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. normadiah_mk@um.edu.my.
authors.forename: Normadiah M
authors.initials: NM
authors.lastname: Kassim
mesh_terms: D000818:Animals; D056705:Apitherapy; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D006722:Honey; D010049:Ovarian Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D006080:Ovarian Follicle / Q000187:drug effects* / Q000473:pathology; D010636:Phenols / Q000009:adverse effects*; D017207:Rats, Sprague-Dawley; D046468:Sexual Development; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds