title: Malignant phyllodes tumor of the breast presenting with hypoglycemia: a case report and literature review.
abstract: Phyllodes tumors are rare fibroepithelial neoplasms that account for less than 1% of all breast tumors and are typically found in middle-aged women. Phyllodes tumors that present with hypoglycemia are even rarer. No one morphologic finding is reliable in predicting the clinical behavior of this tumor. Surgery has been the primary mode of treatment to date. However, the extent of resection and the role of adjuvant radiotherapy or chemotherapy are still controversial. Here, we present a challenging case of malignant phyllodes tumor of the breast associated with hypoglycemia, and review the literature regarding clinical findings, pathologic risk factors for recurrence, and treatment recommendations.
authors.affiliation: Department of Hematology and Oncology, Edwards Comprehensive Cancer Center, Marshall University, Huntington, WV, USA.
authors.forename: Toni
authors.initials: T
authors.lastname: Pacioles
authors.affiliation: Division of Hematology and Oncology, SUNY Upstate Medical University, Syracuse, NY, USA ; Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Seth
authors.affiliation: Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
authors.forename: Cesar
authors.initials: C
authors.lastname: Orellana
authors.affiliation: Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.
authors.forename: Ivy
authors.initials: I
authors.lastname: John
authors.affiliation: Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
authors.forename: Veera
authors.initials: V
authors.lastname: Panuganty
authors.affiliation: Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA ; Division of Endocrinology, SUNY Upstate Medical University, Syracuse, NY, USA.
authors.forename: Ruban
authors.initials: R
authors.lastname: Dhaliwal
keywords: adjuvant treatment; breast cancer; fibroepithelial neoplasm; neuroendocrine tumor; non-islet cell tumor-induced hypoglycemia