title: Computational analyses of arteriovenous malformations in neuroimaging.
abstract: Computational models have been investigated for the analysis of the physiopathology and morphology of arteriovenous malformation (AVM) in recent years. Special emphasis has been given to image fusion in multimodal imaging and 3-dimensional rendering of the AVM, with the aim to improve the visualization of the lesion (for diagnostic purposes) and the selection of the nidus (for therapeutic aims, like the selection of the region of interest for the gamma knife radiosurgery plan). Searching for new diagnostic and prognostic neuroimaging biomarkers, fractal-based computational models have been proposed for describing and quantifying the angioarchitecture of the nidus. Computational modeling in the AVM field offers promising tools of analysis and requires a strict collaboration among neurosurgeons, neuroradiologists, clinicians, computer scientists, and engineers. We present here some updated state-of-the-art exemplary cases in the field, focusing on recent neuroimaging computational modeling with clinical relevance, which might offer useful clinical tools for the management of AVMs in the future.
authors.affiliation: Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.forename: Mounir
authors.initials: M
authors.lastname: Boukadoum
authors.forename: Salim
authors.initials: S
authors.lastname: Lahmiri
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002538:Intracranial Arteriovenous Malformations; D000069550:Machine Learning; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008953:Models, Anatomic; D008959:Models, Neurological; D064847:Multimodal Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
keywords: AVM; Angioarchitecture; arteriovenous malformation; computational modeling; fractal analysis; image biomarker; neuroimaging; segmentation