title: Effects of lidocaine on random skin flap survival in rats.
abstract: BACKGROUND
  Use of a random skin flap is common for repairing wounds and for reconstruction. Lidocaine is a traditional local anesthetic that blocks sodium channels and has positive effects on ischemia-reperfusion injury.
  
  
  OBJECTIVE
  To investigate the effects of lidocaine on random skin flap survival in rats.
  
  
  METHODS
  McFarlane flaps were established in 20 rats divided into 2 groups. Lidocaine was injected in the lidocaine group, and the same concentration of saline was injected in the control group. The survival area of the flaps was measured on Day 7. Levels of inflammation were evaluated by hematoxylin and eosin (H&E)-stained slices, and superoxide dismutase and malonyldialdehyde contents were examined.
  
  
  RESULTS
  The mean survival area of the flaps in the lidocaine group was significantly larger than that in the control group. Superoxide dismutase activity increased significantly in the lidocaine group compared with that in the control group. Malonyldialdehyde level in the lidocaine group was significantly lower than that in the control group. The H&E-stained slices showed that inflammation was clearly inhibited in the lidocaine group.
  
  
  CONCLUSIONS
  Lidocaine improved the survival of random skin flaps.
authors.affiliation: *Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China; †The first Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.forename: Liren
authors.initials: L
authors.lastname: Wang
authors.forename: Dingsheng
authors.initials: D
authors.lastname: Lin
authors.forename: Leyi
authors.initials: L
authors.lastname: Cai
authors.forename: Weiyang
authors.initials: W
authors.lastname: Gao
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D003872:Dermatitis / Q000473:pathology; D004789:Enzyme Activation / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009336:Necrosis / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology*; D016038:Skin Transplantation; D013482:Superoxide Dismutase / Q000378:metabolism; D013524:Surgical Flaps / Q000473:pathology / Q000637:transplantation
chemical_list: D000779:Anesthetics, Local; D008315:Malondialdehyde; D008012:Lidocaine; D013482:Superoxide Dismutase