title: [Allelic imbalance of loci 17p13.1 (TP53), 1p36.1 (RUNX3), 16p22 (CDH1) and microsatellite instability in gastric cancer].
abstract: We examined allelic imbalance (AI) on loci 17p13.1 (TP53), 1p36.1 (RUNX) and 16p22 (CDHI) and microsatellite instability (MI) with BAT26 in 78 patients with gastric cancer. We have shown a significant difference in the frequency of allelic imbalance of the studied loci among different types of gastric cancer. Frequency of AI in 16p22.1 (CDH1) (p = 0.023), 17p13.1 (TP53) (p = 0.038), microsatellite instability (p = 0.047) and AD two and more loci in a single sample (p = 0.0176) was significantly higher in the intestinal type of gastric cancer than in the diffuse type. We have shown, that, frequency of AI in 16p22.1 (CDH1), and AD two and more loci in a single sample, was higher in thetumors with high or moderate type of tumor cells differentiation (p = 0.0414, p = 0.0057 respectively). We found no significant differences in the groups with metastases in regional lymph nodes, different tumor stage, localization of tumors and the generalization process.
authors.forename: M V
authors.initials: MV
authors.lastname: Nemtsova
authors.forename: I I
authors.initials: II
authors.lastname: Bykov
authors.forename: A A
authors.initials: AA
authors.lastname: Udilova
authors.forename: D V
authors.initials: DV
authors.lastname: Zaletaev
authors.forename: T V
authors.initials: TV
authors.lastname: Khorobrykh
mesh_terms: D022981:Allelic Imbalance / Q000235:genetics; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D002877:Chromosomes, Human; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D050677:Core Binding Factor Alpha 3 Subunit; C493729:Runx3 protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53