title: Function and mechanism of tumor suppressor gene LRRC4/NGL-2.
abstract: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/NGL-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/NGL-2 is important for the development of the nervous system. In addition, LRRC4/NGL-2 has been identified as a tumor suppressor gene. The overexpression of LRRC4/NGL-2 suppresses glioma cell growth, angiogenesis and invasion through complicated signaling regulation networks. LRRC4/NGL-2 also has the ability to form multiphase loops with miRNA, transcription factors and gene methylation modification; the loss of LRRC4/NGL-2 function may be an important event in multiple biological processes in gliomas. In summary, LRRC4/NGL-2 is a critical gene in the normal development and tumorigenesis of the nervous system.
authors.forename: Peiyao
authors.initials: P
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Li
authors.affiliation: Hunan Cancer Hospital and the Affiliated Tumor Hospital of Xiangya Medical School Central South University, Changsha, Hunan, China. wuminghua554@aliyun.com.
authors.forename: Minghua
authors.initials: M
authors.lastname: Wu
mesh_terms: D063646:Carcinogenesis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D005910:Glioma / Q000235:genetics; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins