title: Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.
abstract: Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.
authors.affiliation: Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Snyder
authors.affiliation: National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Roderick A
authors.initials: RA
authors.lastname: Corriveau
authors.affiliation: Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Craft
authors.affiliation: Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Faber
authors.affiliation: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: David
authors.initials: D
authors.lastname: Knopman
authors.affiliation: Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Lamb
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
authors.affiliation: Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Maiken
authors.initials: M
authors.lastname: Nedergaard
authors.affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
authors.forename: Chris B
authors.initials: CB
authors.lastname: Schaffer
authors.affiliation: Departments of Pathology and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Schneider
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Wellington
authors.affiliation: Department of Physiology, University of Kentucky, Lexington, KY, USA.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Wilcock
authors.affiliation: Departments of Neurological Surgery and Neurology, Washington University, St Louis, St Louis, MO, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Zipfel
authors.affiliation: Department of Physiology, University of Southern California, Los Angeles, CA, USA.
authors.forename: Berislav
authors.initials: B
authors.lastname: Zlokovic
authors.affiliation: Independent Science Writer, Elverson, PA, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Bain
authors.affiliation: National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bosetti
authors.affiliation: National Institute of Heart, Lung and Blood, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Zorina S
authors.initials: ZS
authors.lastname: Galis
authors.affiliation: National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Walter
authors.initials: W
authors.lastname: Koroshetz
authors.affiliation: Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology*; D003226:Congresses as Topic; D003704:Dementia / Q000503:physiopathology*; D006801:Humans; D054555:National Heart, Lung, and Blood Institute (U.S.); D055825:National Institute of Neurological Disorders and Stroke (U.S.); D012952:Societies; D014481:United States
keywords: Alzheimer's disease; Animal models; Biomarkers; Dementia; Small vessel disease; Vascular dementia