title: In utero preeclampsia exposure, milk intake and pubertal development.
abstract: Cord blood insulin-like growth factor-1 (IGF-1) concentrations are lower in preeclamptic (PE) than normotensive (NT) pregnancies. PE offspring have increased risk of cardiovascular disease and decreased risk of some cancers including breast. We examined the effects of PE exposure in utero, infant feeding and childhood diet at 3-5 years on IGF-1 and breast development in 194 female offspring who were followed from birth until follow-ups at 10.8 and 12.9 years. Diet was not associated with serum IGF-1 levels at 10.8 years. PE exposure was associated with reduced odds of thelarche at 10.8 years only among exclusively breastfed girls. Milk, butter and ice cream consumption at 3-5 years was inversely related to the OR of breast development at 10.8 years. Child's weight and maternal overweight were positively associated with breast development at 10.8 years; child's height and weight were positively associated with breast development at 12.9 years.
authors.affiliation: Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: schrawj@utexas.edu.
authors.forename: Jeremy Michals
authors.initials: JM
authors.lastname: Schraw
authors.affiliation: Intensive Care Unit, Oslo University Hospital, Box 4950, Nydalen, 0424 Oslo, Norway. Electronic address: bjooeg@ous-hf.no.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Øgland
authors.affiliation: Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: kanedong@austin.utexas.edu.
authors.forename: Yong Quan
authors.initials: YQ
authors.lastname: Dong
authors.affiliation: Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norge, Norway. Electronic address: stein.tore.nilsen@sus.no.
authors.forename: Stein Tore
authors.initials: ST
authors.lastname: Nilsen
authors.affiliation: Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: mforman@austin.utexas.edu.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Forman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001827:Body Height; D001835:Body Weight; D001942:Breast Feeding; D002079:Butter; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002657:Child Development; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007054:Ice Cream; D007223:Infant; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016014:Linear Models; D016015:Logistic Models; D042361:Mammary Glands, Human / Q000254:growth & development*; D008892:Milk; D009752:Nutritional Status; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D011627:Puberty; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D004044:Dietary Proteins; C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I; D002079:Butter
keywords: Breast development; Childhood diet; Dairy consumption; Developmental programming; Infant feeding; Preeclampsia; Puberty