title: Sperm cryopreservation in adolescents and young adults with cancer: results of the French national sperm banking network (CECOS).
abstract: OBJECTIVE
  To determine the feasibility of fertility preservation in adolescent males with cancer.
  
  
  METHODS
  Large multicenter retrospective study of male patients ≤20 years from 23 centers of a national network of sperm banks over a 34-year period.
  
  
  METHODS
  Sperm banks.
  
  
  METHODS
  A total of 4,345 boys and young men aged 11 to 20 years.
  
  
  METHODS
  Age, cancer diagnosis, feasibility of sperm banking, and sperm parameters.
  
  
  METHODS
  Description of patients, and success of their fertility preservation.
  
  
  RESULTS
  We observed a mean yearly increase in referred patients of 9.5% (95% confidence interval, 9.1%-9.8%) between 1973 and 2007. Over the study period, the percentage of younger cancer patients who banked their sperm increased, especially in the 11-14 year age group, rising from 1% in 1986 to 9% in 2006. We found that 4,314 patients attempted to produce a semen sample, 4,004 succeeded, and sperm was banked for 3,616. The mean total sperm count was 61.75 × 10(6) for the 11-14 year age group, and 138.81 × 10(6) for the 18-20 year age group. It was noteworthy that intercenter variations in practices involving young patients seeking to preserve their fertility before cancer therapy were observed within this national network.
  
  
  CONCLUSIONS
  Our results emphasize the need for decisive changes in public health policy to facilitate the access to reproductive health-care for young cancer patients.
authors.affiliation: CECOS Midi-Pyrénées, University Hospital of Toulouse, Hôpital Paule de Viguier, Toulouse, France; Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Université de Toulouse-UPS, Toulouse, France. Electronic address: daudin.m@chu-toulouse.fr.
authors.forename: Myriam
authors.initials: M
authors.lastname: Daudin
authors.affiliation: CECOS Haute-Normandie, Reproductive Biology Laboratory and EA 4308 (Spermatogenesis and Male Gamete Quality), Rouen University Hospital, Rouen, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rives
authors.affiliation: Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Université de Toulouse-UPS, Toulouse, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Walschaerts
authors.affiliation: CECOS de Dijon, Reproductive Biology Laboratory, Centre Hospitalier Universitaire de Dijon, Dijon, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Drouineaud
authors.affiliation: CECOS de Caen, Département de Biologie, Unité de Biologie de la Reproduction, CHU de Caen, Caen, France.
authors.forename: Ethel
authors.initials: E
authors.lastname: Szerman
authors.affiliation: CECOS Alsace, Laboratoire de Biologie de la Reproduction, CHU de Strasbourg, Schiltigheim, and Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de Santé et de Recherche Médicale (INSERM) U964/Centre National de Recherche Scientifique (CNRS) UMR 1704/Université de Strasbourg, Strasbourg, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Koscinski
authors.affiliation: CECOS-Service d'Histologie-Embryologie-Cytogénétique, Hôpital Jean Verdier (AP-HP), Bondy, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Eustache
authors.affiliation: CECOS de Marseille, Laboratoire de Biologie de la Reproduction, Hôpital de la Conception, AP-HM, Marseille, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Saïas-Magnan
authors.affiliation: CECOS Aquitaine, Service de Biologie de la Reproduction, CHU de Bordeaux, Université Bordeaux II, Maternité Pellegrin, Bordeaux, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Papaxanthos-Roche
authors.affiliation: CECOS Picardie, Cytogenetic and Reproductive Biology and Medicine Department, University Hospital of Amiens, and Unité INERIS EA 4285-UMI 01, UFR Médecine d'Amiens, Amiens, France.
authors.forename: Rosalie
authors.initials: R
authors.lastname: Cabry-Goubet
authors.affiliation: CECOS Auvergne, Assistance Médicale à la Procréation, CHU Estaing, and Biologie de la Reproduction (EA 975), Université d'Auvergne, Clermont-Ferrand, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Brugnon
authors.affiliation: CECOS de l'Ouest, Unité Biologie de la Reproduction, CHU Rennes, Rennes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Le Lannou
authors.affiliation: CECOS Région Centre-Ouest, Laboratoire de Biologie de la Reproduction, Centre Olympe de Gouges, CHU Bretonneau, Tours, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Barthélémy
authors.affiliation: CECOS Nord, Andrologie, Hôpital Calmette, CHRU de Lille, and EA 4308 Université Lille Nord, Lille, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rigot
authors.affiliation: CECOS de Nantes, Médecine et Biologie et Médecine de la Reproduction, CHU de Nantes, Nantes, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fréour
authors.affiliation: CECOS Paris-Tenon, Service d'Histologie-Biologie de la Reproduction, Hôpital Tenon (AP-HP), Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berthaut
authors.affiliation: CECOS de Lyon, Service de Médecine de la Reproduction, Hôpital Femme Mère Enfant, Bron, and Université Claude Bernard, Biologie Humaine, Lyon, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Giscard d'Estaing
authors.affiliation: CECOS de Nancy, Biologie du Développement et de la Reproduction, CHU Nancy, Maternité Régionale, Nancy, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Touati
authors.affiliation: CECOS Champagne-Ardennes, Service de Génétique, Biologie de la Reproduction, CECOS, CHU Reims, Hôpital Maison Blanche, Reims, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Mélin-Blocquaux
authors.affiliation: CECOS Franche-Comté-Bourgogne, Service de Génétique Biologique, Histologie, Biologie du Développement et de la Reproduction, CHU Besançon, and Sciences Médicales et Pharmaceutiques de Besançon, Université de Franche-Comté, Besançon, France.
authors.forename: Oxana
authors.initials: O
authors.lastname: Blagosklonov
authors.affiliation: CECOS de Grenoble, Laboratoire d'Aide à la Procréation, CHU Grenoble, Hôpital Couple-Enfant, Grenoble, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Thomas
authors.affiliation: CECOS de Nice, Hôpital Archet, CHU Nice, INSERM U895, Nice, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Benhamed
authors.affiliation: CECOS Alsace, Laboratoire de Microbiologie, Centre Hospitalier de Mulhouse, Mulhouse, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Schmitt
authors.affiliation: CECOS Paris-Cochin, Hôpital Cochin (AP-HP), Université Paris Descartes, Paris, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Kunstmann
authors.affiliation: Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Université de Toulouse-UPS, Toulouse, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Thonneau
authors.affiliation: CECOS Midi-Pyrénées, University Hospital of Toulouse, Hôpital Paule de Viguier, Toulouse, France; Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Université de Toulouse-UPS, Toulouse, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Bujan
mesh_terms: D000293:Adolescent; D002648:Child; D019058:Community Networks / Q000639:trends; D015925:Cryopreservation / Q000379:methods* / Q000639:trends; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012662:Semen Preservation / Q000379:methods* / Q000639:trends; D013074:Sperm Banks / Q000379:methods* / Q000639:trends; D055815:Young Adult
keywords: Adolescents; age; cancer; fertility preservation; sperm cryopreservation