title: Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects.
abstract: BACKGROUND
  Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a cholecalciferol (VD3) bolus on VD status in adult burn patients (Group B, GB) after admission, compared to healthy subjects (Group H, GH).
  
  
  METHODS
  Both groups received an oral dose of 100,000 IU VD3. Blood samples were collected before (D0) and 7 days (D7) after bolus to measure 250H-D, 1,25(OH)2-D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). Albumin (ALB) and VD binding protein (DBP) were measured and used to calculate free 25OH-D level. Data were expressed as median (min-max) or proportions.
  
  
  RESULTS
  A total of 49 subjects were included: 29 in GH and 20 in GB. At D0, prevalence of VD deficiency was higher in GB: 25OH-D was 21.5 (10.1-46.3) ng/ml in GH vs 11 (1.8-31.4) ng/ml in GB. DBP and ALB were lower in GB. At D7, DBP was stable in both groups while ALB decreased in GB. 25OH-D increased by 66.6 (13.5-260.3)% in GH. In GB, changes in 25OH-D extended from -36.7% to 333.3% with a median increase of 33.1%. Similar changes were observed in each group for free 25OH-D. High FGF23 levels were observed in GB.
  
  
  CONCLUSIONS
  This study highlighted the differences in VD status and in response to a high dose VD3 in burn patients when compared to healthy patients. Pitfalls in VD status assessment are numerous during acute burn care: 25OH-D measurement needs cautious interpretation and interest of free 25OH-D is still questionable. They should not prevent burn patients to receive VD supplements during acute care. Higher doses than general recommendations should probably be considered.
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Sart-Tilman B35, B-4000 Liège, Belgium. Electronic address: afrousseau@chu.ulg.ac.be.
authors.forename: Anne-Françoise
authors.initials: AF
authors.lastname: Rousseau
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Sart-Tilman B35, B-4000 Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Damas
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Sart-Tilman B35, B-4000 Liège, Belgium.
authors.forename: Didier
authors.initials: D
authors.lastname: Ledoux
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Sart-Tilman, Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lukas
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Sart-Tilman, Liège, Belgium.
authors.forename: Agnès
authors.initials: A
authors.lastname: Carlisi
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Sart-Tilman, Liège, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Le Goff
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Sart-Tilman, Liège, Belgium.
authors.forename: Romy
authors.initials: R
authors.lastname: Gadisseur
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Sart-Tilman, Liège, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000097:blood*; D016022:Case-Control Studies; D002762:Cholecalciferol / Q000494:pharmacology*; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012709:Serum Albumin; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*; D014809:Vitamin D-Binding Protein / Q000097:blood; D014815:Vitamins / Q000494:pharmacology*; D055815:Young Adult
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D012709:Serum Albumin; D014809:Vitamin D-Binding Protein; D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; D005346:Fibroblast Growth Factors; C097949:1,25-dihydroxyvitamin D; D000089703:Fibroblast Growth Factor-23; C104450:25-hydroxyvitamin D
keywords: Burn; Cholecalciferol; Fibroblast growth factor 23; Free 25-hydroxyvitamin D; Vitamin D; Vitamin D binding protein