title: "Optimized" delivery of intracoronary supersaturated oxygen in acute anterior myocardial infarction: a feasibility and safety study.
abstract: OBJECTIVE
  We sought to evaluate the feasibility and safety of catheter-based supersaturated oxygen (SSO2 ) delivery via the left main coronary artery (LMCA) following primary percutaneous coronary intervention (PCI).
  
  
  BACKGROUND
  In the multicenter, randomized AMIHOT-II trial, SSO2 delivered into the proximal or mid left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) following primary PCI significantly reduced infarct size but resulted in a numerically higher incidence of safety events.
  
  
  METHODS
  Patients with acute anterior STEMI presenting within 6 hr of symptom onset were enrolled at three centers. Following successful LAD stenting, SSO2 was infused into the LMCA via a diagnostic catheter for 60 min. The primary safety endpoint was the 30-day rate of target vessel failure (composite of death, reinfarction, or target vessel revascularization). Cardiac magnetic resonance imaging (cMRI) was performed at 3-5 and 30 days to assess infarct size.
  
  
  RESULTS
  Twenty patients with acute anterior STEMI were enrolled. The infarct lesion was located in the proximal LAD in 7 cases (35%) and the mid LAD in 13 cases (65%). Following primary PCI, SSO2 was delivered successfully in all cases. Target vessel failure within 30 days occurred in 1 patient (5%). Median [interquartile range] infarct size was 13.7% [5.4-20.6%] at 3-5 days and 9.6% [2.1-14.5%] at 30 days.
  
  
  CONCLUSIONS
  Following primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA is feasible, and is associated with a favorable early safety and efficacy profile.
authors.affiliation: Beaumont Health System, Royal Oak, Michigan.
authors.forename: Ivan D
authors.initials: ID
authors.lastname: Hanson
authors.affiliation: Providence Hospital, Southfield, Michigan.
authors.forename: Shukri W
authors.initials: SW
authors.lastname: David
authors.affiliation: Beaumont Health System, Royal Oak, Michigan.
authors.forename: Simon R
authors.initials: SR
authors.lastname: Dixon
authors.affiliation: Wellmont Holston Valley Medical Center, Kingsport, Tennessee.
authors.forename: D Christopher
authors.initials: DC
authors.lastname: Metzger
authors.affiliation: Hôpital Du Sacré-Coeur De Montréal, Montréal, Québec, Canada.|Columbia University Medical Center, New York, New York.|Cardiovascular Research Foundation, New York, New York.
authors.forename: Philippe
authors.initials: P
authors.lastname: Généreux
authors.affiliation: Columbia University Medical Center, New York, New York.|Cardiovascular Research Foundation, New York, New York.
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.affiliation: Cardiovascular Research Foundation, New York, New York.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Columbia University Medical Center, New York, New York.|Cardiovascular Research Foundation, New York, New York.
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
mesh_terms: D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003331:Coronary Vessels; D004562:Electrocardiography; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007269:Injections, Intra-Arterial; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D010100:Oxygen / Q000008:administration & dosage*; D062645:Percutaneous Coronary Intervention; D016896:Treatment Outcome
chemical_list: D010100:Oxygen
keywords: ST-segment elevation myocardial infarction; percutaneous coronary intervention; supersaturated oxygen