title: Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs.
abstract: The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, respectively.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France.
authors.forename: Nabil
authors.initials: N
authors.lastname: El Brahmi
authors.forename: Serge M
authors.initials: SM
authors.lastname: Mignani
authors.forename: Joachim
authors.initials: J
authors.lastname: Caron
authors.forename: Saïd
authors.initials: S
authors.lastname: El Kazzouli
authors.forename: Mosto M
authors.initials: MM
authors.lastname: Bousmina
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Majoral
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004976:Ethacrynic Acid / Q000737:chemistry* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D010758:Phosphorus / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D010758:Phosphorus; D004976:Ethacrynic Acid