title: Ground control to Major Tom: "prepare for HIV landing".
abstract: Productive HIV-1 infection requires viral cDNA integration into the host genome, an event catalyzed by HIV-1 integrase. In this issue of Cell Host & Microbe, Demeulemeester et al. (2014) report the existence of natural integrase polymorphisms that retarget viral integration away from gene-dense regions and are associated with rapid disease progression.
authors.affiliation: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany; Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy. Electronic address: marina.lusic@med.uni-heidelberg.de.
authors.forename: Marina
authors.initials: M
authors.lastname: Lusic
authors.affiliation: Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy. Electronic address: giacca@icgeb.org.
authors.forename: Mauro
authors.initials: M
authors.lastname: Giacca
mesh_terms: D015658:HIV Infections / Q000201:enzymology*; D019427:HIV Integrase / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D016662:Virus Integration
chemical_list: D019427:HIV Integrase