title: Targeting sterol metabolism for the development of antileishmanials.
abstract: Membrane sterol profiles differ between humans and Leishmania parasites, and the sterol pathway has been investigated for potential therapeutic targets. Recently, mutants of the C14α-sterol demethylase in Leishmania major were found to have several major alterations such as increased membrane fluidity, hypersensitivity to heat stress, and severe reduction of virulence.
authors.affiliation: Antiparasitic Chemotherapy, UMR 8076 CNRS BioCIS, Labex LERMIT, University Paris-Sud, 5 rue Jean-Baptiste Clément, 92290- Châtenay-Malabry, France. Electronic address: sebastien.pomel@u-psud.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Pomel
authors.affiliation: Antiparasitic Chemotherapy, UMR 8076 CNRS BioCIS, Labex LERMIT, University Paris-Sud, 5 rue Jean-Baptiste Clément, 92290- Châtenay-Malabry, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Cojean
authors.affiliation: Antiparasitic Chemotherapy, UMR 8076 CNRS BioCIS, Labex LERMIT, University Paris-Sud, 5 rue Jean-Baptiste Clément, 92290- Châtenay-Malabry, France.
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
mesh_terms: D000818:Animals; D056890:Eukaryota / Q000378:metabolism*; D005260:Female; D007891:Leishmania / Q000378:metabolism*; D013261:Sterols / Q000096:biosynthesis*
chemical_list: D013261:Sterols
keywords: Leishmania sp.; antileishmanial agents; biological target; sterol metabolism