title: [Analysis of possible causes activation a stomach and pancreas excretory and incretory function after completion of space flight on the international space station].
abstract: The research excretory and incretory of activity of a stomach and pancreas is carried out at astronauts in the early period after completion of space flights of various duration. It is shown, that the increase of the contents of gastric and pancreatic enzymes and hormones (insulin and C-peptide) in blood reflects increased excretory and incretory activity of organs of gastroduodenal area which arises in weightlessness. The complex of countermeasures, which prevent ingress of subjects, infected by Helicobacter pylori in space flight crew, excluded participation of this microorganism in the mechanism of increase of secretory activity of a stomach. The absence of interrelation between increase of secretory activity of gastroduodenal area organs and space flights' duration has allowed to exclude the hypokinetic mechanism which determined by duration of stay in weightlessness. It was shown that after the end of space flights the increase ofbasal excretory activity of organs of gastroduodenal area occurs simultaneously with increase of a fasting insulin secretion. The changes in gastroduodenal area organs revealed after space flights were are compared to similar changes received in ground-based experiments, simulating hemodynamic reorganization in venous system of abdominal cavity, arising in weightlessness. The conclusion is made, that the basic mechanism of changes of a functional condition of digestive system in space flights, is determined by reorganization venous hemodynamic in abdominal cavity organs reproduced in ground experiments. Increase insulin and C-peptide after space flights are considered as hormonal component of this hemodynamic mechanism.
authors.forename: B V
authors.initials: BV
authors.lastname: Afonin
mesh_terms: D002096:C-Peptide / Q000097:blood; D016481:Helicobacter Infections / Q000097:blood / Q000503:physiopathology*; D016480:Helicobacter pylori; D006439:Hemodynamics; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D046790:Pancreas, Exocrine / Q000378:metabolism / Q000503:physiopathology; D013026:Space Flight; D013270:Stomach / Q000503:physiopathology*
chemical_list: D002096:C-Peptide; D007328:Insulin