title: Hormonal therapy (hCG and rhFSH) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism.
abstract: Adult-onset idiopathic male hypogonadotropic hypogonadism (IMHH) is a very rare but treatable disease. This study was conducted to examine the efficacy and safety of a combination of human chorionic gonadotropin (hCG) and recombinant human follicle-stimulating hormone (rhFSH) for inducing spermatogenesis in men with adult-onset IMHH. Seven men (34-45 years of age) with azoospermia and/or sexual dysfunction, with a low serum testosterone concentration, and apulsatile secretion of luteinizing hormone, were referred to our hospital for infertility. All had normal secondary sexual characteristics. Thorough endocrinologic examination and magnetic resonance imaging revealed no identifiable cause of hypogonadotropic hypogonadism. Adult-onset IMHH was diagnosed in all cases and treatment was started with 150 IU rhFSH and 5,000 IU hCG, both administered two times per week. Spermatogenesis was restored in five of the seven patients. During treatment one patient achieved spontaneous pregnancy with his wife, and spermatozoa recovered from the other four patients were frozen for future use in intracytoplasmic sperm injection.
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital , oshigaya, Saitama , Japan and.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Kobori
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Iwahata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shin
authors.forename: Ryo
authors.initials: R
authors.lastname: Sato
authors.forename: Kojiro
authors.initials: K
authors.lastname: Nishio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.forename: Gaku
authors.initials: G
authors.lastname: Arai
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Soh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
mesh_terms: D000328:Adult; D017668:Age of Onset; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005303:Fertility Agents, Male / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007248:Infertility, Male / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013091:Spermatogenesis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D005303:Fertility Agents, Male; D011994:Recombinant Proteins; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Adult-onset idiopathic male hypogonadotropic hypogonadism; human chorionic gonadotropin; recombinant human follicle-stimulating hormone; spermatogenesis