title: [SAGA complex: the role in viability and development].
abstract: SAGA is a histone acetyltransferase complex, that cotranscriptionally performs histone modifications and is implicated in regulation of gene expression at the level of changes in chromatin structure. SAGA is also involved in mRNP biogenesis and export. In this review, we examined a contribution of SAGA and its subunits in the development. We also discuss the diseases associated with impaired activity of SAGA subunits.
authors.forename: D Ia
authors.initials: DIa
authors.lastname: Gurskiĭ
authors.forename: D V
authors.initials: DV
authors.lastname: Kopytova
authors.forename: S G
authors.initials: SG
authors.lastname: Georgieva
authors.forename: E N
authors.initials: EN
authors.lastname: Nabirochkina
mesh_terms: D000107:Acetylation; D000818:Animals; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics; D004331:Drosophila melanogaster; D018507:Gene Expression Regulation, Developmental; D051548:Histone Acetyltransferases / Q000096:biosynthesis* / Q000235:genetics; D006657:Histones / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012261:Ribonucleoproteins / Q000235:genetics / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014158:Transcription, Genetic; D054875:Ubiquitination / Q000235:genetics; D000099224:p300-CBP-Associated Factor
chemical_list: D029721:Drosophila Proteins; D051548:Histone Acetyltransferases; D006657:Histones; D012261:Ribonucleoproteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; C507785:SAGA complex, S cerevisiae; C026452:messenger ribonucleoprotein; C470557:GCN5 protein, Drosophila; D000099224:p300-CBP-Associated Factor