title: Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat.
abstract: Wnt signaling is as a major regulator of adipogenesis. It differentially regulates the fate of mesenchymal stem cells (MSC) by promoting osteogenesis and myogenesis, and inhibiting adipogenesis[1]. Its loss of function has been associated with impaired osteogenesis[2] and diverse congenital and adult cardiovascular disorders[3,4]. Our group has identified loss of function mutations in Wnt coreceptor LRP6 that underlie autosomal dominant early onset coronary artery (CAD), osteoporosis and most features of the metabolic syndrome, including high plasma triglyceride and LDL-C, diabetes, hypertension, hyperuricemia and fatty liver disease (unpublished data). Following we will describe our most pertinent findings related to Wnt/LRP6 regulation of de novo lipogenesis and adipogenesis and the role of impaired Wnt signaling in generation of ectopic fat, insulin resistance, elevated plasma lipids and non-alcoholic fatty liver disease (NAFLD).
authors.affiliation: Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT.
authors.forename: Kangxing
authors.initials: K
authors.lastname: Song
authors.affiliation: Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Cornell University, Ithaca, NY.
authors.forename: Mitra
authors.initials: M
authors.lastname: Mani
authors.affiliation: Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT. Department of Genetics, Yale University School of Medicine, New Haven, CT.
authors.forename: Arya
authors.initials: A
authors.lastname: Mani
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000096:biosynthesis*; D050155:Lipogenesis / Q000502:physiology*; D051379:Mice; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D008055:Lipids; D051153:Wnt Proteins