title: The effect of Emdogain gel on periodontal regeneration in autogenous transplanted dog's teeth.
abstract: OBJECTIVE
  The aim of this study was to assess the enamel matrix derivative (EMD) as biomaterial used in autogenous tooth transplantation.
  
  
  METHODS
  The study consisted of 3 beagle dogs, 5 months old, in which six incisors and six premolars were transplanted to mechanically prepared recipient alveolar sockets. One group of teeth was transplanted to a recipient bed, with EMD in the root surface. The second groups of teeth were transplanted using saline solution in the root surface. Every week, clinical examinations were done. Nine weeks later, the animals were killed and the specimens decalcified and prepared for histological and imunohistochemical analysis. Periodontal healing was evaluated by undertaking histomorphometric investigation and analyzed using the Mann- Whitney test (P = 0.05).
  
  
  RESULTS
  In both groups, all the transplanted teeth survived. Between the experimental groups, there was statistically significant difference in the complete healing (P = 0.004). There was statistically significant difference between the treatment group in the occurrence of inflammatory root resorption (P = 0.015) and the occurrence of replacement root resorption (P = 0.041).
  
  
  CONCLUSIONS
  Emdogain gel used on the surface of transplanted teeth improves the occurrence of complete healing and reduces root resorption.
authors.affiliation: Department of Dentistry, University of Coimbra, Portugal, .
authors.forename: Manuel Marques
authors.initials: MM
authors.lastname: Ferreira
authors.forename: Botelho Maria
authors.initials: BM
authors.lastname: Filomena
authors.forename: Carvalho
authors.initials: C
authors.lastname: Lina
authors.forename: Oliveiros
authors.initials: O
authors.lastname: Barbara
authors.forename: Carrilho Eunice Virginia
authors.initials: CE
authors.lastname: Palmeirao
mesh_terms: D000818:Animals; D064592:Autografts / Q000187:drug effects / Q000637:transplantation*; D001641:Bicuspid / Q000187:drug effects / Q000637:transplantation*; D003094:Collagen / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D003739:Dental Cementum / Q000187:drug effects / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D007180:Incisor / Q000187:drug effects / Q000637:transplantation*; D008297:Male; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010011:Osteocytes / Q000187:drug effects / Q000473:pathology; D010513:Periodontal Ligament / Q000187:drug effects / Q000473:pathology; D010519:Periodontium / Q000187:drug effects* / Q000473:pathology; D012038:Regeneration / Q000187:drug effects*; D012391:Root Resorption / Q000473:pathology / Q000517:prevention & control; D014092:Tooth Root / Q000187:drug effects; D020390:Tooth Socket / Q000187:drug effects / Q000601:surgery
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D003094:Collagen