title: Comparison of split-dosing vs non-split (morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy.
abstract: OBJECTIVE
  To compare (using the Ottawa Bowel Preparation Scale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the optimal preparation-to-colonoscopy interval.
  
  
  METHODS
  Single-centre, prospective, randomized, investigator-blind stud in an academic tertiary-care centre. Two hundred patients requiring elective colonoscopy were assigned to receive one of the two preparation regimens (split vs morning) prior to colonoscopy. Main outcome measurements were bowel preparation quality and patient tolerability.
  
  
  RESULTS
  Split-dose regimen resulted in better bowel preparation compared to morning regimen [Ottawa score mean 5.52 (SD 1.23) vs 6.02 (1.34); P = 0.017]. On subgroup analysis, for afternoon procedures, both the preparations were equally effective (P = 0.756). There was no difference in tolerability and compliance between the two regimens.
  
  
  CONCLUSIONS
  Overall, previous evening - same morning split-dosing regimen results in better bowel cleansing for colonoscopy compared to morning preparation. For afternoon procedures, both schedules are equally effective; morning preparation may be more convenient to the patient.
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Hardik
authors.initials: H
authors.lastname: Shah
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Desai
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Hrishikesh
authors.initials: H
authors.lastname: Samant
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Davavala
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Joshi
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Gupta
authors.affiliation: Hardik Shah, Devendra Desai, Hrishikesh Samant, Sandeep Davavala, Anand Joshi, Tarun Gupta, Philip Abraham, Division of Gastroenterology, P D Hinduja National Hospital, Mumbai 400016, Maharashtra, India.
authors.forename: Philip
authors.initials: P
authors.lastname: Abraham
keywords: Bowel preparation; Colonoscopy; Morning preparation; Preparation to colonoscopy interval; Split dose preparation