title: Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years.
abstract: The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24-123). At baseline, the mean eGFR was 152 ml/min/1.73 m(2) (105-227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m(2) (SD, 33) at T0 to 140 ml/min/1.73 m(2) (SD, 33) at T2 and 123 ml/min/1.73 m(2) (SD, 14) at T3. The decrease of eGFR was significant, with ΔGFR (T3-T0) of -29 ml/min/1.73 m(2) (SD, 30; p < 0.0001) and a mean ΔGFR per year of -6 and ml/min/1.73 m(2) (SD, 8).
  
  
  CONCLUSIONS
  We noted a long-term decline in eGFR in this small cohort of mother-to-child HIV-infected adolescents receiving TDF-containing cART, even if the lack of a control group and the small sample size are major limitations.
authors.affiliation: Infectious Diseases Unit, IRCCS San Martino University Hospital-IST, University of Genoa, L.go Rosanna Benzi 10, 16132, Genoa, Italy, sara.grignolo@gmail.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Grignolo
authors.forename: Paola
authors.initials: P
authors.lastname: Tatarelli
authors.forename: Giulia
authors.initials: G
authors.lastname: Gustinetti
authors.forename: Francesca
authors.initials: F
authors.lastname: Viazzi
authors.forename: Barbara
authors.initials: B
authors.lastname: Bonino
authors.forename: Paolo
authors.initials: P
authors.lastname: Maggi
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D000068698:Tenofovir / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir