title: [Study on action mechanism of adjuvant therapeutic effect compound Ejiao slurry in treating cancers based on network pharmacology].
abstract: Recently, compound Ejiao slurry (FFEJJ) had been applied to treat cancer patients in clinic, with obvious curative effect. In this study, data and literatures were collected from the TCM chemical component database to establish the chemical component database of FFEJJ. Afterwards, MetaDrug software was used to predict the targets of FFEJJ and obtain the compound-target network. Next, the compound-target network was compared and analyzed to obtain the "compound-target-tumor target" heterogeneous network. Besides, further analysis was made on gene functions and metabolic pathway. The results indicated that FFEJJ could directly resist tumors by regulating cancer cell differentiation, growth, proliferation and apoptosis, and show an adjuvant therapeutic effect by enriching the blood and increasing the immunity.
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Xu
authors.forename: Song-Song
authors.initials: SS
authors.lastname: Wang
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Bian
authors.forename: Shou-Sheng
authors.initials: SS
authors.lastname: Tian
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Lu
authors.forename: Xiang-Shan
authors.initials: XS
authors.lastname: Zhou
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: You
authors.forename: Lu-Qi
authors.initials: LQ
authors.lastname: Huang
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D053263:Gene Regulatory Networks / Q000187:drug effects*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism
chemical_list: D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal