title: Meta-analysis demonstrates no association between XRCC1 Arg399Gln polymorphism and bladder cancer risk.
abstract: We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies showed no significant association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in comparisons of the glutamine (Gln) allele vs arginine (Arg) allele, Arg/Arg vs (Gln/Gln + Gln/Arg), Gln/Gln vs (Gln/Arg + Arg/Arg), Gln/Gln vs Arg/Arg, and Gln/Arg vs Arg/Arg [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.80-1.16, P = 0.70; OR = 1.13, 95%CI = 0.70-1.82, P = 0.62; OR = 0.92, 95%CI = 0.79-1.07, P = 0.29; OR = 0.90, 95%CI = 0.69-1.16, P = 0.42; OR = 0.89, 95%CI = 0.75-1.05, P = 0.17, respectively]. In subgroup analysis by ethnicity, no association was observed between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in Caucasian, Mongoloid, or black populations. We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk.
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: L M
authors.initials: LM
authors.lastname: Dong
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Shengjing Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: H
authors.initials: H
authors.lastname: Teng
authors.affiliation: Department of Emergency Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: M S
authors.initials: MS
authors.lastname: Li
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China cmu4h_wp@126.com.
authors.forename: P
authors.initials: P
authors.lastname: Wang
mesh_terms: D000483:Alleles; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human