title: Single dendrite-targeting interneurons generate branch-specific inhibition.
abstract: Microcircuits composed of dendrite-targeting inhibitory interneurons and pyramidal cells (PCs) are fundamental elements of cortical networks, however, the impact of individual interneurons on pyramidal dendrites is unclear. Here, we combine paired recordings and calcium imaging to determine the spatial domain over which single dendrite-targeting interneurons influence PCs in olfactory cortex. We show that a major action of individual interneurons is to inhibit dendrites in a branch-specific fashion.
authors.affiliation: Department of Neuroscience, Center for Neural Circuits and Behavior, School of Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Caleb C A
authors.initials: CC
authors.lastname: Stokes
authors.affiliation: Department of Neuroscience, Center for Neural Circuits and Behavior, School of Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Corinne M
authors.initials: CM
authors.lastname: Teeter
authors.affiliation: Department of Neuroscience, Center for Neural Circuits and Behavior, School of Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Jeffry S
authors.initials: JS
authors.lastname: Isaacson
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology*; D005260:Female; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D066194:Olfactory Cortex / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology; D011963:Receptors, GABA-A / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D046509:Tissue Culture Techniques
chemical_list: D011963:Receptors, GABA-A; D002118:Calcium
keywords: IPSP/C (inhibitory postsynaptic potential/current); backpropagating action potential; olfactory cortex; piriform cortex; pyramidal cells