title: Chlorpyrifos exposure and respiratory health among adolescent agricultural workers.
abstract: Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function.
authors.affiliation: Department of Epidemiology and Environmental Health, State University of New York at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA. clc46@buffalo.edu.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Callahan
authors.affiliation: Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Egypt. manal_1970@yahoo.com.
authors.forename: Manal
authors.initials: M
authors.lastname: Al-Batanony
authors.affiliation: Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Egypt. aa-ismail@hotmail.com.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Ismail
authors.affiliation: Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Egypt. gaafar237@yahoo.com.
authors.forename: Gaafar
authors.initials: G
authors.lastname: Abdel-Rasoul
authors.affiliation: Clinical Pathology and Hematology and Immunology, Menoufia University, Shebin El-Kom 32511, Egypt. olfat_hendy@hotmail.com.
authors.forename: Olfat
authors.initials: O
authors.lastname: Hendy
authors.affiliation: Department of Epidemiology and Environmental Health, State University of New York at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA. jolson@buffalo.edu.
authors.forename: James R
authors.initials: JR
authors.lastname: Olson
authors.affiliation: Department of Occupational and Environmental Health, University of Iowa, 145 N. Riverside Drive 100 CPHB Iowa City, IA 52242, USA. diane-rohlman@uiowa.edu.
authors.forename: Diane S
authors.initials: DS
authors.lastname: Rohlman
authors.affiliation: Department of Epidemiology and Environmental Health, State University of New York at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA. mrbonner@buffalo.edu.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Bonner
mesh_terms: D000293:Adolescent; D000383:Agriculture; D015415:Biomarkers; D004390:Chlorpyrifos / Q000633:toxicity*; D004534:Egypt; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D016273:Occupational Exposure; D010865:Pilot Projects; D011728:Pyridones / Q000652:urine*; D012135:Respiratory Sounds / Q000187:drug effects*; D013147:Spirometry
chemical_list: D015415:Biomarkers; D007306:Insecticides; D011728:Pyridones; C012587:3,5,6-trichloro-2-pyridinol; D004390:Chlorpyrifos