title: The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.
abstract: Although the hypoxia-inducible factor (HIF)-hydroxylase oxygen-sensing pathway has been extensively reviewed in the context of cellular responses to hypoxia and cancer biology, its importance in regulating innate immune biology is less well described. In this review, we focus on the role of the HIF-hydroxylase pathway in regulating myeloid cell responses and its relevance to inflammatory lung disease. The more specific roles of individual HIF/ prolyl hydroxylase pathway members in vivo are discussed in the context of lineage-specific rodent models of inflammation, with final reference made to the therapeutic challenges of targeting the HIF/hydroxylase pathway in immune cells.
authors.affiliation: Academic Unit of Respiratory Medicine, Department of Infection and Immunity, The Medical School, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Moira K B
authors.initials: MK
authors.lastname: Whyte
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Walmsley
mesh_terms: D000818:Animals; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D007111:Immunity, Cellular; D008168:Lung / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D011014:Pneumonia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: hydroxylase; hypoxia inducible factor; inflammation; macrophage; neutrophil