title: Henoch-Schonlein purpura in mesothelioma.
abstract: Henoch-Schonlein purpura (HSP) is primarily a childhood immunoglobulin A (IgA)-mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75-year-old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.
authors.affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.
authors.forename: Stuti
authors.initials: S
authors.lastname: Joshi
authors.affiliation: PathWest Laboratory Medicine, QE II Med Ctr Perth, Western Australia, Australia.
authors.forename: Sooraj
authors.initials: S
authors.lastname: Pillai
authors.affiliation: Department of Renal Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.
authors.forename: Aron
authors.initials: A
authors.lastname: Chakera
authors.affiliation: Centre of Asthma, Allergy and Respiratory Research, School of Medicine and Pharmacology, University of Western Australia Perth, Western Australia, Australia.
authors.forename: Y C Gary
authors.initials: YC
authors.lastname: Lee
keywords: Henoch–Schonlein purpura; mesothelioma; pleura; renal failure; vasculitis