title: Highly selective synthesis of functionalized polyhydroisoquinoline derivatives via a three-component domino reaction.
abstract: Two series of novel functionalized polyhydroisoquinoline derivatives have been synthesized via the three-component domino reaction of glutaraldehyde and malononitrile with a series of β-ketoamides under microwave irradiation conditions in the presence of a catalytic amount of Et3N (10 mol%). This reaction represents the first reported process for the facile conversion of a β-ketoamide to a hydroisoquinoline via a C-N bond cleavage reaction without the need for a multistep reaction process.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. dqshi@suda.edu.cn.
authors.forename: Xian
authors.initials: X
authors.lastname: Feng
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Zhan
authors.initials: Z
authors.lastname: Xun
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D000577:Amides / Q000737:chemistry / Q000528:radiation effects; D002384:Catalysis; D005976:Glutaral / Q000737:chemistry / Q000528:radiation effects; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry / Q000528:radiation effects
chemical_list: D000577:Amides; D007546:Isoquinolines; D009570:Nitriles; C000945:dicyanmethane; D005976:Glutaral