title: Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.
abstract: OBJECTIVE
  The aim of this study was to establish guidelines for the optimization of biologic therapies for health professionals involved in the management of patients with RA, AS and PsA.
  
  
  METHODS
  Recommendations were established via consensus by a panel of experts in rheumatology and hospital pharmacy, based on analysis of available scientific evidence obtained from four systematic reviews and on the clinical experience of panellists. The Delphi method was used to evaluate these recommendations, both between panellists and among a wider group of rheumatologists.
  
  
  RESULTS
  Previous concepts concerning better management of RA, AS and PsA were reviewed and, more specifically, guidelines for the optimization of biologic therapies used to treat these diseases were formulated. Recommendations were made with the aim of establishing a plan for when and how to taper biologic treatment in patients with these diseases.
  
  
  CONCLUSIONS
  The recommendations established herein aim not only to provide advice on how to improve the risk:benefit ratio and efficiency of such treatments, but also to reduce variability in daily clinical practice in the use of biologic therapies for rheumatic diseases.
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain Isidoro.ga@ser.es.
authors.forename: Isidoro
authors.initials: I
authors.lastname: González-Álvaro
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez-Fernández
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Benito
authors.initials: B
authors.lastname: Dorantes-Calderón
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: García-Vicuña
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Hernández-Cruz
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Herrero-Ambrosio
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Olatz
authors.initials: O
authors.lastname: Ibarra-Barrueta
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Martín-Mola
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Monte-Boquet
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Morell-Baladrón
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Raimon
authors.initials: R
authors.lastname: Sanmartí
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz-Sanz
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: de Toro-Santos
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Vela
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Román Ivorra
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Poveda-Andrés
authors.affiliation: Rheumatology Service, Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Madrid, Research Unit, Spanish Rheumatology Society, Madrid, Hospital Pharmacy Clinical Management Unit, Hospital de Valme, Seville, Rheumatology Clinical Management Unit, Hospital Universitario Virgen Macarena, Seville, Hospital Pharmacy Service, Hospital Universitario La Paz, IdiPaz, Madrid, Hospital Pharmacy Service, Hospital de Galdakano-Usansolo, Vizcaya, Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Hospital Pharmacy Service, Hospital Universitari i Politécnic La Fe, Valencia, Hospital Pharmacy Service, Hospital Universitario de La Princesa, Madrid, Rheumatology Service, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Rheumatology Service, Hospital Puerta de Hierro, Madrid, Rheumatology Service, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña (CHUAC), Sergas. Universidade da Coruña, A Coruña, Rheumatology Section, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, Rheumatology Service, Hospital Universitari i Politécnic La Fe, Valencia andRheumatology Service, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Muñoz-Fernández
mesh_terms: D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*
chemical_list: D001688:Biological Products
keywords: ankylosing spondylitis; bDMARD; biologics; cDMARD; dose reduction; optimization; psoriatic arthritis; rheumatoid arthritis; risk/benefit ratio