title: Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide.
abstract: Insertion of an anthranilic acid in an amyloidogenic peptide sequence generates a novel conformationally restricted α/β-hybrid peptide that inhibits amyloid formation of Aβ(1-40) and disrupts preformed fibrillar aggregates in vitro. Such β-sheet breaker hybrid peptides (BSBHps) may be useful for designing novel physiologically important compounds relevant to diverse amyloidoses and for studying the process of aggregation.
authors.affiliation: Laboratory of Peptide and Amyloid Research, Department of Chemistry, Indian Institute of Technology Guwahati, Assam - 781039, India. bmandal@iitg.ernet.in.
authors.forename: Ashim
authors.initials: A
authors.lastname: Paul
authors.forename: Krishna Chaitanya
authors.initials: KC
authors.lastname: Nadimpally
authors.forename: Tanmay
authors.initials: T
authors.lastname: Mondal
authors.forename: Kishore
authors.initials: K
authors.lastname: Thalluri
authors.forename: Bhubaneswar
authors.initials: B
authors.lastname: Mandal
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D002942:Circular Dichroism; D006801:Humans; D046529:Microscopy, Electron, Transmission; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D062367:ortho-Aminobenzoates; C031385:anthranilic acid