title: [Structural and functional peculiarities of lymphocytes from patients with lymphoblastic leukemia].
abstract: New data on the structure and properties of the cell surface of lymphocytes from the blood of patients with CLL, ALL and ALL at remission stage has been obtained using AFM technologies. It's been shown that, despite the presence of immature lymphocytes in the blood flow of patients with CLL and ALL, the mechanical properties and geometrical parameters of the cells are different. Lymphocytes of CLL patients had an increased volume and higher stiffness, while the cells from the blood of patients with ALL and ALL in remission had decreased stiffness, which allowed the cells to spread on the substrate, thereby the volumes increased due to their reduced height and increased diameter. Identified structural and functional peculiarities of white blood cells from the patients with leukemia can be used for prognosis of the cancer progression.
authors.forename: E A
authors.initials: EA
authors.lastname: Sladkova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Skorkina
mesh_terms: D016022:Case-Control Studies; D048429:Cell Size; D055119:Elastic Modulus; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000473:pathology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure*; D018625:Microscopy, Atomic Force; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000473:pathology*; D012074:Remission Induction