title: The membrane level of procaine pharmacology.
abstract: In almost all the pharmacological effects of procaine, the biological membranes are invoked as final target of the drug. The membrane impact could be an interaction (generally, a specific one) with a membrane receptor (a protein-like biomolecule-enzyme, carrier, pharmacological or hormonal receptor, etc.) or a nonspecific interaction with membrane lipids, alterring their structure and dynamics. These two different mechanisms are discussed in the light of the experimental results obtained from studies on model systems (artificial membranes liposomes), on neuronal, muscular, erythrocytar and bacterial membranes. Finally, some considerations are made about the connexion with membrane changing in aging organisms.
authors.forename: C T
authors.initials: CT
authors.lastname: Crăercu
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000187:drug effects*; D002462:Cell Membrane / Q000187:drug effects; D049830:Cephalopoda / Q000187:drug effects; D005434:Flow Cytometry; D005453:Fluorescence; D006801:Humans; D008081:Liposomes; D008563:Membrane Lipids; D008567:Membranes, Artificial; D011343:Procaine / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D008081:Liposomes; D008563:Membrane Lipids; D008567:Membranes, Artificial; D011343:Procaine