title: Autoregulation of blood flow: Vessel diameter changes in response to different temperatures.
abstract: Autoregulation of blood flow is a marvelous phenomenon balancing blood supply and tissue demand. Although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. The biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comprehensively. One important aspect of autoregulation phenomenon is temperature changes of the tissue resulted from tissue metabolism. We hypothesize that temperature changes can affect the mechanical properties of the vessel wall leading to vessel diameter changes during autoregulation. Mechanical modeling of vessel diameter changes can also be useful to explain other phenomena in which the vessel diameter changes in response to temperature alterations. Through the mechanical modeling of any vessel, the analysis of temperature-induced changes in vessel diameter can be done more precisely.
authors.affiliation: Eye Research Center, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Norouzpour
authors.affiliation: Department of Mechanical Engineering, Mechanical Engineering College, Shiraz University, Shiraz, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Hooshyar
authors.affiliation: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mehdizadeh
keywords: Autoregulation; Temperature; Vasoconstriction; Vasodilation; Vessel diameter