title: Diagnostic capability of peripapillary retinal thickness in glaucoma using 3D volume scans.
abstract: OBJECTIVE
  To determine the diagnostic capability of spectral-domain optical coherence tomography (SD OCT) peripapillary retinal thickness (RT) measurements from 3-dimensional (3D) volume scans for primary open-angle glaucoma (POAG).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  setting: Institutional. study population: 156 patients (89 POAG and 67 normal subjects). observation procedures: One eye of each subject was included. SD OCT peripapillary RT values from 3D volume scans were calculated for 4 quadrants of 3 different sized annuli. Peripapillary retinal nerve fiber layer (RNFL) thickness values were also determined. main outcome measures: Area under the receiver operating characteristic curve (AUROC) values, sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios.
  
  
  RESULTS
  The top 5 RT AUROCs for all glaucoma patients and for a subset of early glaucoma patients were for the inferior quadrant of outer circumpapillary annulus of circular grid (OCA) 1 (0.959, 0.939), inferior quadrant of OCA2 (0.945, 0.921), superior quadrant of OCA1 (0.890, 0.811), inferior quadrant of OCA3 (0.887, 0.854), and superior quadrant of OCA2 (0.879, 0.807). Smaller RT annuli OCA1 and OCA2 consistently showed better diagnostic performance than the larger RT annulus OCA3. For both RNFL and RT measurements, best AUROC values were found for inferior RT OCA1 and OCA2, followed by inferior and overall RNFL thickness.
  
  
  CONCLUSIONS
  Peripapillary RT measurements from 3D volume scans showed excellent diagnostic performance for detecting both glaucoma and early glaucoma patients. Peripapillary RT values have the same or better diagnostic capability compared to peripapillary RNFL thickness measurements, while also having fewer algorithm errors.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Simavli
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Christian John
authors.initials: CJ
authors.lastname: Que
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akduman
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Rizzo
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
authors.forename: Edem
authors.initials: E
authors.lastname: Tsikata
authors.affiliation: Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: de Boer
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address: teresa_chen@meei.harvard.edu.
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Chen
mesh_terms: D000368:Aged; D019540:Area Under Curve; D003430:Cross-Sectional Studies; D005189:False Positive Reactions; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012160:Retina / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence