title: Mass Spectral and Chromatographic Studies on Some Halogenatedphenyl-2-Piperazinopropanones.
abstract: Gas chromatography-mass spectrometry (GC-MS) studies on the halogenatedphenyl-2-piperazinopropanones (XPPPOs): Twelve XPPPOs were subdivided into four groups of compounds and studied using GC-MS. The four studied groups include the three ring-substituted fluorophenylpiperazinopropanones, chlorophenylpiperazinopropanones, bromophenylpiperazinopropanones and trifluoromethylphenylpiperazinopropanones. The three compounds in each group have equal mass and many common mass spectral fragment ions. Perfluoroacylation of the secondary amine nitrogen of these isomeric piperazines gave mass spectra with differences in relative abundance of some fragment ions but acylation did not alter the fragmentation pathway and did not provide additional MS fragments of discrimination among these isomers. The perfluoroacyl derivatives of these piperazines were resolved on a stationary phase of 100% trifluoropropyl methyl polysiloxane (Rtx-200).
authors.affiliation: Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt kmh0012@auburn.edu.
authors.forename: Karim M
authors.initials: KM
authors.lastname: Abdel-Hay
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D054879:Halogenation; D007536:Isomerism; D010879:Piperazines / Q000737:chemistry*
chemical_list: D010879:Piperazines; D000096:Acetone