title: Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals.
abstract: The level of transcriptional activity of a gene is regulated by epigenetic processes. There is compelling evidence that environmental challenges throughout the life course can induce phenotypic change. In this review, we summarize the current evidence, focusing specifically on the effects of nutrition and of environmental pollutants, that epigenetic processes underpin the induction by environmental change of altered phenotypic traits, emphasizing the implications for health outcomes. We also discuss whether epigenetic processes may be involved in the passage of induced traits between generations. Overall, current findings indicate that epigenetic processes may play an important role in determining disease risk, but there is a lack of studies that demonstrate causal links between epigenetic change and tissue function.
authors.affiliation: Faculty of Natural & Environmental Sciences, Southampton General Hospital, University of Southampton, SO16 6YD, UK.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Lillycrop
authors.forename: Graham C
authors.initials: GC
authors.lastname: Burdge
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004194:Disease / Q000209:etiology*; D004785:Environmental Pollutants; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000502:physiology*; D009752:Nutritional Status; D010641:Phenotype; D012307:Risk Factors
chemical_list: D004785:Environmental Pollutants
keywords: DNA methylation; diet; epigenetics; histones; pollution; transgeneration