title: Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer.
abstract: A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability of NAD(+) to maintain the continuity of glycolysis. It is therefore an important control point in the system of cellular energy release. Its upregulation is common in many malignant tumors. Inhibiting LDH-5 activity has an anti-proliferative effect on cancer cells. It may reverse their resistance to conventional chemo- and radiotherapy. Recent research has renewed interest in LDH-5 as an anticancer drug target. This review summarizes recent studies exploring the role of LDH-5 in cancer growth, its utility as a tumor marker, and developments made in identifying and designing anti-LDH-5 therapeutic agents.
authors.affiliation: Department of Gastrointestinal and General Surgery, Wroclaw Medical University, ul. Sklodowskiej-Curie 66, 50-369 Wroclaw, Poland. Electronic address: katarzyna.augoff@am.wroc.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Augoff
authors.affiliation: Laboratory of Cytobiochemistry, Biotechnology Faculty, University of Wroclaw, Wroclaw, Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Hryniewicz-Jankowska
authors.affiliation: Department of Gastrointestinal and General Surgery, Wroclaw Medical University, ul. Sklodowskiej-Curie 66, 50-369 Wroclaw, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Tabola
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002952:Citric Acid Cycle / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006019:Glycolysis / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D000080864:Lactate Dehydrogenase 5; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000628:therapy
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5
keywords: Aerobic glycolysis; Cancer metabolism; Lactate dehydrogenase 5 (LDH-5)