title: Comparison of proctocolectomy and ileal pouch-anal anastomosis to colectomy and ileorectal anastomosis in familial adenomatous polyposis.
abstract: Prophylactic surgical options for familial adenomatous polyposis (FAP) are either colectomy and ileorectal anastomosis (IRA) or proctocolectomy and ileal pouch-anal anastomosis (IPAA). The aim of this study was to analyse the short-term and long-term outcomes of these two operative techniques. All patients with FAP in Finland have been prospectively recorded in a database since 1963 were retrospectively reviewed in this analysis. Altogether 140 (61%) colectomies with IRA and 88 (39%) proctocolectomies with IPAA have been performed. Complications occurred in 28 (21%) patients after IRA and in 26 (30%) patients after IPAA. There were 15 (11%) severe complications for IRA and 5 (6%) for IPAA. Twenty-one (15%) patients of the IRA group ended up in conventional ileostomy whereas 3 (3.4%) patients of the IPAA group had their ileal reservoir converted to an ileostomy (p = 0.01). Cumulative survival for IRA was lower than for the IPAA (p = 0.03), but if accounting only for operations made after the IPAA era had commenced, there was no significant difference. IPAA was associated with improved long-term survival without an increase in postoperative complications. The risk of death after colectomy and IRA seemed to be predominantly related to the remaining risk of rectal cancer. Therefore, we favour proctocolectomy with IPAA as the prophylactic surgical procedure for FAP with intermediate or severe polyposis.
authors.affiliation: Department of Gastrointestinal and General Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029, HUS, Helsinki, Finland, laura.koskenvuo@hus.fi.
authors.forename: L
authors.initials: L
authors.lastname: Koskenvuo
authors.forename: H
authors.initials: H
authors.lastname: Mustonen
authors.forename: L
authors.initials: L
authors.lastname: Renkonen-Sinisalo
authors.forename: H J
authors.initials: HJ
authors.lastname: Järvinen
authors.forename: A
authors.initials: A
authors.lastname: Lepistö
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods*; D003082:Colectomy / Q000009:adverse effects; D039021:Colonic Pouches / Q000009:adverse effects; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012007:Rectum / Q000601:surgery*