title: Dopamine modulates the neural representation of subjective value of food in hungry subjects.
abstract: Although there is a rich literature on the role of dopamine in value learning, much less is known about its role in using established value estimations to shape decision-making. Here we investigated the effect of dopaminergic modulation on value-based decision-making for food items in fasted healthy human participants. The Becker-deGroot-Marschak auction, which assesses subjective value, was examined in conjunction with pharmacological fMRI using a dopaminergic agonist and an antagonist. We found that dopamine enhanced the neural response to value in the inferior parietal gyrus/intraparietal sulcus, and that this effect predominated toward the end of the valuation process when an action was needed to record the value. Our results suggest that dopamine is involved in acting upon the decision, providing additional insight to the mechanisms underlying impaired decision-making in healthy individuals and clinical populations with reduced dopamine levels.
authors.affiliation: Departments of Psychiatry, Wellcome Trust-MRC Institute of Metabolic Science, and nm483@cam.ac.uk.
authors.forename: Nenad
authors.initials: N
authors.lastname: Medic
authors.affiliation: Departments of Psychiatry, Wellcome Trust-MRC Institute of Metabolic Science, and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5EF, United Kingdom.
authors.forename: Hisham
authors.initials: H
authors.lastname: Ziauddeen
authors.affiliation: Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom, and.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Vestergaard
authors.affiliation: Wellcome Trust-MRC Institute of Metabolic Science, and.
authors.forename: Elana
authors.initials: E
authors.lastname: Henning
authors.affiliation: Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom, and.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Schultz
authors.affiliation: Wellcome Trust-MRC Institute of Metabolic Science, and.
authors.forename: I Sadaf
authors.initials: IS
authors.lastname: Farooqi
authors.affiliation: Departments of Psychiatry, Wellcome Trust-MRC Institute of Metabolic Science, and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5EF, United Kingdom.
authors.forename: Paul C
authors.identifier: http://orcid.org/0000-0001-8257-1517
authors.initials: PC
authors.lastname: Fletcher
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D005502:Food; D006801:Humans; D006815:Hunger / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D055815:Young Adult
chemical_list: D004298:Dopamine
keywords: decision; dopamine; food; reward; value