title: Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions.
abstract: Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.
authors.affiliation: Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy. mcmonti@unisa.it casapullo@unisa.it.
authors.forename: L
authors.initials: L
authors.lastname: Margarucci
authors.forename: M C
authors.initials: MC
authors.lastname: Monti
authors.forename: A
authors.initials: A
authors.lastname: Tosco
authors.forename: R
authors.initials: R
authors.lastname: Esposito
authors.forename: A
authors.initials: A
authors.lastname: Zampella
authors.forename: V
authors.initials: V
authors.lastname: Sepe
authors.forename: M
authors.initials: M
authors.lastname: Mozzicafreddo
authors.forename: R
authors.initials: R
authors.lastname: Riccio
authors.forename: A
authors.initials: A
authors.lastname: Casapullo
mesh_terms: D000818:Animals; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D054464:Peroxiredoxins / Q000737:chemistry / Q000378:metabolism*; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D047232:Theonella / Q000737:chemistry*
chemical_list: D001688:Biological Products; D013256:Steroids; C000602664:theonellasterone; D054464:Peroxiredoxins