title: New potential solutions for the chemolysis of urinary phosphate calculi determined by an in vitro study.
abstract: To find a more efficient solution for chemolysis of urinary calculi, several organic acids were chosen to form solutions by consulting the composition of a classic solution, Suby G. The solutions together with Renacidin, another classic solution, were designed to react with the 4 phosphate components of urinary stone. The processes were real-time measured and analysed by a focused beam reflectance measurement, and the efficiency factors were investigated and discussed in detail. The results show that several organic acids, e.g. hydroxyacetic acid, lactic acid and α-ketoglutaric acid, are more efficient than citric acid in dissolving urinary phosphate calculus. The new solutions containing the organic acids are promising for improving chemolysis treatment.
authors.affiliation: Department of Urology, Xiaolan Hospital of Southern Medical University, Zhongshan, 528415, China.
authors.forename: Jinqing
authors.initials: J
authors.lastname: Zhang
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Jingfan
authors.initials: J
authors.lastname: Hong
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000143:Acids / Q000627:therapeutic use; D019999:Pharmaceutical Solutions / Q000627:therapeutic use*; D010710:Phosphates / Q000032:analysis*; D014545:Urinary Calculi / Q000737:chemistry* / Q000178:diet therapy*
chemical_list: D000143:Acids; D019999:Pharmaceutical Solutions; D010710:Phosphates