title: CD226 rs727088A>G polymorphism increases the susceptibility to gastric cancer in Chinese populations.
abstract: Gastric cancer (GC) is one of the most common cancers worldwide, especially in Asia. The development of GC is a multifactorial process and numerous studies have linked genetic variation to GC risk. In this study, we evaluated the effects of single nucleotide polymorphisms (SNPs) of CD226 on GC susceptibility in Chinese populations including 687 cancer patients and 936 control subjects. We found that the G allele of the rs727088A>G polymorphism in the 3'-untranslated region of CD226 was significantly associated with risk of GC using logistic regression (P<10(-3)). GC patients who harbored the rs727088G allele had significantly increased cancer risk (odds ratio=1.43, 95% confidence interval=1.23-1.67) compared with those patients harboring the rs727088A allele. Moreover, functional relevance was further performed that individuals carrying the rs727088G allele were correlated with lower expression level of CD226 than individuals carrying the rs727088AA homozygous genotype. These findings indicated that functional polymorphism rs727088A>G in CD226 might modify the susceptibility for the development of GC.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China; Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi 214041, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi 214041, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Lv
authors.affiliation: Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi 214041, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address: jfzhang@nju.edu.cn.
authors.forename: Jun Feng
authors.initials: JF
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi 214041, China. Electronic address: zhoupingwuxi@126.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D044466:Asian People; D001483:Base Sequence; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D002681:China / Q000453:epidemiology; D003609:Dactinomycin / Q000494:pharmacology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012907:Smoking; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D020413:3' Untranslated Regions; D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; D019384:Nucleic Acid Synthesis Inhibitors; D003609:Dactinomycin
keywords: CD226; Gastric cancer; Polymorphisms