title: Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT.
abstract: The first BNCT antitumor effects of BNNTs toward B16 melanoma cells were demonstrated. The use of DSPE-PEG2000 was effective for preparation of the BNNT-suspended aqueous solution. BNNT-DSPE-PEG2000 accumulated in B16 melanoma cells approximately three times higher than BSH and the higher BNCT antitumor effect was observed in the cells treated with BNNT-DSPE-PEG2000 compared to those treated with BSH, indicating that BNNT-DSPE-PEG2000 would be a possible candidate as a boron delivery vehicle for BNCT.
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan; Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. Electronic address: hiro@res.titech.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Koganei
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Miyoshi
authors.affiliation: Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.affiliation: Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001896:Boron Compounds / Q000008:administration & dosage* / Q000737:chemistry; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000532:radiotherapy*; D043942:Nanotubes / Q000737:chemistry; D009502:Neutrons; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents; D001896:Boron Compounds; C017282:boron nitride
keywords: Antitumor effect; B16 melanoma cells; Boron neutron capture therapy (BNCT); Boron nitride nanotubes (BNNTs); Colony-forming assay