title: [Risk factors for non-sentinel lymph node metastasis in patients after neoadjuvant chemotherapy].
abstract: OBJECTIVE
  To evaluate the risk factors for non-sentinel lymph node (NSLN) metastasis in patients after neoadjuvant chemotherapy (NCT) so as to develop a new predictive model.
  
  
  METHODS
  A total of 512 consecutive patients with metastasis in sentinel lymph node (SLN) on neoadjuvant chemotherapy between August 2005 and March 2013 were recruited to evaluate the factors affecting the involvement of NSLN. Logistic regression analysis was performed to construct a predictive model.
  
  
  RESULTS
  There were 115 (22.4%) patients with metastasis in NSLN after axillary lymph node dissection. Univariate analysis showed that tumor size, number of positive SLN, hormone receptor (HR), micrometastasis and clinical response of primary tumor after NCT were associated with the involvement of NSLN (P < 0.05). Multivariate analysis indicated that tumor size, number of positive SLN, HR, micrometastasis and clinical response of primary tumor after NCT were significant independent predictors for NSLN metastasis. Area under the curve was 0.779.
  
  
  CONCLUSIONS
  Tumor size, number of positive SLN, HR, micrometastasis and clinical response of primary tumor after NCT were significant independent predictors for NSLN metastasis in patients after NCT. The new model is to be further validated.
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Yingjian
authors.initials: Y
authors.lastname: He
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Wang
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Tie
authors.initials: T
authors.lastname: Fan
authors.affiliation: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China. Email: ouyanghongtao@263.net.
authors.forename: Tao
authors.initials: T
authors.lastname: Ouyang
mesh_terms: D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D020360:Neoadjuvant Therapy; D061206:Neoplasm Micrometastasis; D009369:Neoplasms; D012307:Risk Factors