title: The duration of hypotension determines the evolution of bacteremia-induced acute kidney injury in the intensive care unit.
abstract: BACKGROUND
  Exploration of the impact of severe hypotension on the evolution of acute kidney injury in septic patients.
  
  
  RESULTS
  We reviewed the hemodynamic parameters of 137 adults with septic shock and proven blood stream infection in the ICU. Severe hypotension was defined as a mean arterial blood pressure (MAP) ≤65 mmHg. The influence of the duration of severe hypotension on the evolution of acute kidney injury was evaluated according to the RIFLE classification, with day 0 defined as the day of a positive blood stream infection. After bloodstream infection, the probability for a patient to be in Failure was significantly higher than before blood stream infection (OR = 1.94, p = 0.0276). Patients have a significantly higher risk of evolving to Failure if the duration of severe hypotension is longer (OR = 1.02 for each 10 minutes increase in duration of a MAP <65 mmHg, p = 0.0472). A cut-off of at least 51 minutes of severe hypotension (<65 mmHg) or at least 5.5 periods of severe hypotension within 1 day identified patients with increased risk to evolve to Failure.
  
  
  CONCLUSIONS
  There is a significant influence of both the duration and the number of periods of severe hypotension on the evolution to Failure. Blood stream infection has a significantly negative effect on the relationship between severe hypotension and Failure.
authors.affiliation: Department of Nephrology-Hypertension, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
authors.forename: Karin
authors.initials: K
authors.lastname: Janssen van Doorn
authors.affiliation: Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
authors.forename: Walter
authors.initials: W
authors.lastname: Verbrugghe
authors.affiliation: Department of Biostatistics, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
authors.forename: Kristien
authors.initials: K
authors.lastname: Wouters
authors.affiliation: Department of Microbiology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
authors.forename: Hilde
authors.initials: H
authors.lastname: Jansens
authors.affiliation: Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Jorens
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D016470:Bacteremia / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000150:complications*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications*