title: Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate.
abstract: The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected.
authors.forename: Venkata
authors.initials: V
authors.lastname: Srikanth Meka
authors.forename: Vanitha A P Hong
authors.initials: VA
authors.lastname: Wee Liang
authors.forename: Senthil Rajan
authors.initials: SR
authors.lastname: Dharmalingham
authors.forename: Ravi
authors.initials: R
authors.lastname: Sheshala
authors.forename: Adinarayana
authors.initials: A
authors.lastname: Gorajana
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002227:Carbazoles / Q000008:administration & dosage* / Q000737:chemistry; D000077261:Carvedilol; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D011412:Propanolamines / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D004337:Drug Carriers; D005079:Excipients; D011135:Polysaccharides, Bacterial; D011412:Propanolamines; D013607:Tablets; D000077261:Carvedilol; D020442:Poloxamer; D011092:Polyethylene Glycols; D011205:Povidone; C002563:xanthan gum