title: Take your PICS: moving from GWAS to immune function.
abstract: Many of the hits identified through genome-wide association studies are located outside protein-coding regions, making it difficult to define mechanism. In Nature, Farh et al., (2014) describe an approach to identify causal variants in autoimmune disease as first step to assigning function.
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Eyre
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address: jane.worthington@manchester.ac.uk.
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*