title: Alpha-lipoic acid modifies circulating angiogenic factors in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  In recent years interest has been focused on angiogenesis as a process involved in coronary artery disease (CAD) and diabetic distal sensorimotor polyneuropathy (DSPN). Recent studies have demonstrated the possible angiogenesis-modulating potential of alpha-lipoic acid (ALA) for DSPN and CAD. The aim of our study was to investigate the influence of ALA on serum angiogenic factors in patients with DM-2 (type 2 diabetes) with CAD and DSPN.
  
  
  METHODS
  Sixty patients with type 2 DM (T2DM) and CAD and 25 non-diabetic subjects were studied. Thirty patients with T2DM, CAD and DSPN were given 600 mg of ALA a day for 90 days. VEGF, bFGF, MCP-1, angiogenin, IL-12 and IL-10 concentrations in the sera were measured by flow cytometry.
  
  
  RESULTS
  ALA significantly increased VEGF, bFGF and IL-10 and decreased MCP-1 serum concentrations in patients with T2DM and CAD and DSPN. VEGF and IL-10 serum levels, both before and after ALA-treatment, were higher in this group than in T2DM and CAD patients, while circulating bFGF was higher and MCP-1 serum level lower in patients with T2DM and CAD and DSPN only in the post-ALA-treatment, compared to the T2DM and CAD group.
  
  
  CONCLUSIONS
  ALA may influence angiogenesis in type 2 diabetic patients through an effect on some circulating factors including VEGF, bFGF, MCP-1 and IL-10.
authors.affiliation: Department of Pharmacology, Poznan University of Medical Sciences, Poznań, Poland. Electronic address: mdworac@ump.edu.pl.
authors.forename: Marzena
authors.initials: M
authors.lastname: Dworacka
authors.affiliation: Department of Pharmacology, West Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Saule
authors.initials: S
authors.lastname: Iskakova
authors.affiliation: Poznan Specialist Center of Medical Care, Diabetology Out-patient Clinic, Poznań, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Krzyżagórska
authors.affiliation: Department of Pharmacology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wesołowska
authors.affiliation: Department of Pharmacology, West Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Yergen
authors.initials: Y
authors.lastname: Kurmambayev
authors.affiliation: Department of Clinical Immunology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Dworacki
mesh_terms: D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D012307:Risk Factors; D008063:Thioctic Acid / Q000494:pharmacology* / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D043925:Angiogenesis Inducing Agents; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D016753:Interleukin-10; D008063:Thioctic Acid
keywords: Alpha-lipoic acid; IL-10; MCP-1; Type 2 diabetes; VEGF; bFGF