title: The analysis of linear and monomethylalkanes in exhaled breath samples by GC×GC-FID and GC-MS/MS.
abstract: A new arrangement of the INCAT (inside needle capillary adsorption trap) device with Carbopack X and Carboxen 1000 as sorbent materials was applied for sampling, preconcentration and injection of C6C19n-alkanes and their monomethyl analogs in exhaled breath samples. For the analysis both GC-MS/MS and GC×GC-FID techniques were used. Identification of the analytes was based on standards, measured retention indices and selective SRM transitions of the individual isomers. The GC-MS/MS detection limits were in the range from 2.1 pg for n-tetradecane to 86 pg for 5-methyloctadecane. The GC×GC-FID detection limits ranged from 19 pg for n-dodecane to 110 pg for 3-methyloctane.
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hengerics Szabó
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Podolec
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Viktória
authors.initials: V
authors.lastname: Ferenczy
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia. Electronic address: kubinec@fns.uniba.sk.
authors.forename: Róbert
authors.initials: R
authors.lastname: Kubinec
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Blaško
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Soják
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Renáta
authors.initials: R
authors.lastname: Górová
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Addová
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Ostrovský
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia; SynthCluster, s.r.o., Komenského 1439, 900 01 Modra, Slovakia.
authors.forename: Jozef
authors.initials: J
authors.lastname: Višňovský
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Albertov 6, 128 43 Prague 2, Czech Republic.
authors.forename: Václav
authors.initials: V
authors.lastname: Bierhanzl
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Albertov 6, 128 43 Prague 2, Czech Republic; Institute of Forensic Medicine and Toxicology, General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
authors.forename: Radomír
authors.initials: R
authors.lastname: Čabala
authors.affiliation: Univ.-Clinic of Anesthesia and Intensive Care, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria; Breath Research Institute of the University of Innsbruck, Rathausplatz 4, A-6850 Dornbirn, Austria.
authors.forename: Anton
authors.initials: A
authors.lastname: Amann
mesh_terms: D000473:Alkanes / Q000032:analysis* / Q000737:chemistry; D001944:Breath Tests / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D000473:Alkanes
keywords: Exhaled breath; INCAT; Monomethylalkanes; Needle trap; n-Alkanes