title: Microbiological effects of periodontal therapy plus azithromycin in patients with diabetes: results from a randomized clinical trial.
abstract: Current evidence suggests that periodontal infection may aggravate diabetes control. The aim of this study was to determine the changes in the frequency with which Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Aggregatibacter actinomycetemcomitans were detected in patients with diabetes with the use of non-surgical therapy plus azithromycin in a randomized clinical trial. One hundred and five (105) patients with diabetes and chronic periodontitis were randomly assigned to three treatment groups: subgingival mechanical therapy with azithromycin, subgingival mechanical therapy with placebo and supragingival prophylaxis with azithromycin. Complete periodontal clinical examinations and detection of periodontal pathogens using polymerase chain reaction were carried out at baseline, 3, 6 and 9 months after periodontal therapy. The frequency with which Porphyromonas gingivalis, Treponemadenticola and Aggregatibacter actinomycetemcomitans were detected decreased at 3 months in all groups. Tannerella forsythia increased after3 months in all groups. All organisms had similar frequencies at 9 months in all groups. Subgingival mechanical therapy with adjunctive azithromycin had no additional effect on the frequency with which the periodontal pathogens investigated were detected in patients with diabetes.
authors.affiliation: Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Hincapié
authors.affiliation: Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Castrillón
authors.affiliation: Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
authors.forename: Fanny L
authors.initials: FL
authors.lastname: Yepes
authors.affiliation: Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Roldan
authors.affiliation: Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
authors.forename: María A
authors.initials: MA
authors.lastname: Becerra
authors.affiliation: School of Dentistry, University del Valle, Cali, Colombia.
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Moreno
authors.affiliation: School of Dentistry, University del Valle, Cali, Colombia.
authors.forename: Jessika
authors.initials: J
authors.lastname: Consuegra
authors.affiliation: School of Dentistry, University del Valle, Cali, Colombia.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Contreras
authors.affiliation: School of Dentistry, University del Valle, Cali, Colombia.
authors.forename: Javier E
authors.initials: JE
authors.lastname: Botero
mesh_terms: D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D058491:Bacterial Load / Q000187:drug effects; D001439:Bacteroides / Q000187:drug effects / Q000302:isolation & purification; D055113:Chronic Periodontitis / Q000188:drug therapy / Q000382:microbiology* / Q000628:therapy; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D048909:Diabetes Complications / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057747:Periodontal Debridement / Q000379:methods*; D010919:Placebos; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000302:isolation & purification; D048373:Treponema denticola / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D017963:Azithromycin