title: Clinical significance of resistin expression in osteoarthritis: a meta-analysis.
abstract: BACKGROUND
  The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.
  
  
  METHODS
  Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.
  
  
  RESULTS
  Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.
  
  
  CONCLUSIONS
  These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.
authors.affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.
authors.forename: Xiao-Chuan
authors.initials: XC
authors.lastname: Li
authors.affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000235:genetics* / Q000473:pathology; D052243:Resistin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D052243:Resistin