title: Oral lesion as unusual first manifestation of multiple myeloma: case reports and review of the literature.
abstract: Extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites.
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy ; Ospedale Ferrarotto, Divisione di Ematologia, Via Citelli 6, 95124 Catania, Italy ; Scuola Superiore di Catania, Via San Nullo 5 I, 95125 Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy ; Scuola Superiore di Catania, Via San Nullo 5 I, 95125 Catania, Italy ; 1st Section of Dentistry, Department of Surgery, University of Catania, Via Citelli 6, 95124 Catania, Italy.
authors.forename: M S
authors.initials: MS
authors.lastname: Marescalco
authors.affiliation: 1st Section of Dentistry, Department of Surgery, University of Catania, Via Citelli 6, 95124 Catania, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Liardo
authors.affiliation: Division of Pathology, AOU "Policlinico-Vittorio Emanuele", Via Plebiscito 628, 95100 Catania, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Villari
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy ; Scuola Superiore di Catania, Via San Nullo 5 I, 95125 Catania, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Vetro
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Conticello
authors.affiliation: Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Di Raimondo
authors.affiliation: 1st Section of Dentistry, Department of Surgery, University of Catania, Via Citelli 6, 95124 Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ferlito