title: [Emerging disease-modifying therapies for multiple sclerosis].
abstract: Multiple sclerosis(MS) is an inflammatory demyelinating disease of the central nervous system with yet undetermined etiology. The incidence of MS is rapidly rising in Japan, and in addition to four already-approved disease-modifying therapies (DMTs), namely interferon β1b, interferonβ1a, fingolimod and natalizumab, several new DMTs are currently under clinical trials. In this article, emerging DMTs such as alemtuzumab, dimethyl fumarate and teriflunomide as well as fampridine, a novel symptomatic treatment for gait disturbance, and anti-LINGO-1 monoclonal antibody, a possible candidate for future remyelination therapy, will be reviewed. Future treatment strategies such as induction therapy and combined therapy for MS will also be discussed.
authors.forename: Jin
authors.initials: J
authors.lastname: Nakahara
mesh_terms: D001812:Blood-Brain Barrier; D017326:Clinical Trials, Phase III as Topic; D015195:Drug Design; D006801:Humans; D060828:Induction Chemotherapy; D009103:Multiple Sclerosis / Q000188:drug therapy*