title: Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures: The role of adipose tissue in febrile seizures.
abstract: Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS (n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group (p < 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group (p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines (p > 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey asamiguven@hotmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Güven
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: F D
authors.initials: FD
authors.lastname: Icagasioglu
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Duksal
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Sancakdar
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Alaygut
authors.affiliation: Department of Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: E B
authors.initials: EB
authors.lastname: Uysal
authors.affiliation: Department of Pediatrics, Sivas Government Hospital, Sivas, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Akkar
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: M B
authors.initials: MB
authors.lastname: Oflaz
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kaya
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D011446:Prospective Studies; D003294:Seizures, Febrile / Q000378:metabolism* / Q000473:pathology*
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D006454:Hemoglobins; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein
keywords: Adipocytokines; IL-6; adiponectin; febrile seizures; leptin