title: Two new coumarins from Talaromyces flavus.
abstract: Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: He
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Qin
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Run-Qiao
authors.initials: RQ
authors.lastname: Kuang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. 1018yuyang@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. tyaoxs@jnu.edu.cn.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry; D066329:Protein Aggregates; D013211:Staphylococcus aureus / Q000187:drug effects; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D003374:Coumarins; D010446:Peptide Fragments; D066329:Protein Aggregates; C075222:amyloid beta-protein (1-42); C000600625:talacoumarin A; C000600626:talacoumarin B