title: Haplotype approach for association analysis on hypertension.
abstract: We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also conducted for the whole chromosome 3. We found 1 block from the ULK4 gene and 2 blocks from the LOC64690 gene that were significantly associated with hypertension.
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9 ; Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 4G1.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9 ; Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 4G1.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Espin-Garcia
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: Xin
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario, Canada M5T 3L9.
authors.forename: Yonathan
authors.initials: Y
authors.lastname: Brhane
authors.affiliation: Ontario Cancer Institute/Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9 ; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9 ; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu