title: Reducing outbreaks: using international governmental risk pools to fund research and development of infectious disease medicines and vaccines.
abstract: The deadliest Ebola outbreak the world has ever seen is currently ravaging West Africa, despite the concerted efforts of the World Health Organization and many national governments. The current picture is troubling, but not altogether unexpected. Ebola was initially identified in 1976, and since that time, few drugs have been developed to combat it. The same is true for myriad other dangerous infectious diseases to which the world is currently susceptible. One proposal that might prevent outbreaks of this scale and magnitude from recurring would be to have the World Health Organization (WHO) and its technical partners assess which of its member states are at high risk for a disease, either directly or indirectly, and facilitate the creation of international governmental risk pools of those member states. Risk pools would offer open-indexed grant contracts to fund vaccine and drug development for a particular disease, and pharmaceutical companies could browse the index to apply for these grants. If the risk-pool states and a particular company sign a contract, a mutually agreed upon amount of the vaccine or drug would be produced at a below-market purchase price for those states. In return, the company would keep any patents or intellectual property rights for the developed vaccines or drugs. Risk-pool countries that did not use their vaccine or drug could resell that supply on secondary markets to other countries outside of the risk pool. This arrangement will increase the supply of tested drug and vaccine candidates available for combatting unexpected outbreaks of any previously discovered major infectious disease in the future.
authors.affiliation: Yale School of Medicine, New Haven, Connecticut.
authors.forename: J Mark
authors.initials: JM
authors.lastname: Erfe
mesh_terms: D004196:Disease Outbreaks / Q000191:economics / Q000517:prevention & control*; D004345:Drug Industry; D006076:Government; D006801:Humans; D055552:Infectious Disease Medicine / Q000191:economics*; D038622:Internationality; D012106:Research / Q000191:economics*; D012109:Research Support as Topic / Q000191:economics*; D012307:Risk Factors; D014612:Vaccines / Q000191:economics*; D014944:World Health Organization
chemical_list: D014612:Vaccines
keywords: development; drug; economic; international; risk pools; risk sharing; vaccine