title: Prolonged severe immunodeficiency following thymectomy and radiation: a case report.
abstract: BACKGROUND
  Immunodeficiency can occur both in patients undergoing radiation therapy, as well as in patients who have had thymectomies. However, few studies have examined the immune recovery of a patient following both procedures. We aim to emphasize the need for assessment and consistent monitoring of patients with thymoma prior to and after combined treatment of thymectomy and radiation, both of which are likely to result in an increased risk for immunodeficiency.
  
  
  METHODS
  We describe the longitudinal progress of a 59-year-old Asian male who underwent thymectomy followed by radiation therapy and subsequently presented with generalized urticaria. Revelation of a low absolute lymphocyte count (615 cells/mcL) on initial evaluation prompted further analysis of his immunoglobulin levels and antigen response to a polysaccharide pneumococcal vaccine (PneumoVax-23). Although his immunoglobulin levels were unremarkable, he failed to respond to 11 of 12 serotypes of the pneumococcal vaccine. As a result, he was placed on Bactrim® (trimethoprim-sulfamethoxazole) prophylaxis to prevent opportunistic infections, and his CD4+ and CD8+ counts were monitored over the course of 8 years. His lymphocyte counts 87 months after thymectomy and 85 months after radiation therapy were as follows: absolute lymphocyte count 956 cells/mcL, absolute CD3+/CD4+ 164/mm3 (16%) and absolute CD3+/CD8+ 257/mm3 (25%). The patient was able to discontinue Bactrim® (trimethoprim-sulfamethoxazole) prophylaxis after 9 years of treatment.
  
  
  CONCLUSIONS
  The lymphocytopenia, low CD4+ count, and failed response to pneumococcal vaccination that presented in our patient are consistent with immunodeficiency. After radiation alone, a recovery of T-lymphocytes is usually observed after approximately 3 weeks. Over the course of 8 years, he has still not made a full recovery according to laboratory markers, which seem to have stabilized at chronically low levels. To prevent serious complications, we suggest that patients who have undergone both thymectomy and radiation therapy be monitored for immunodeficiency. This case report informs the practices of allergists, oncologists, and neurologists in the continuing care of patients with thymoma.
authors.forename: Johanna Lee
authors.initials: JL
authors.lastname: Wickemeyer
authors.affiliation: Medstar Union Memorial Hospital, 3333 N Calvert St, Suite 520, Baltimore, MD 21218, USA. asthma4@yahoo.com.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sekhsaria
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D013934:Thymectomy; D013945:Thymoma / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery*; D013953:Thymus Neoplasms / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D007136:Immunoglobulins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination