title: Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.
abstract: BACKGROUND
  Embolization of the left gastric artery (LGA) reduces circulating levels of ghrelin, but might prevent from further obesity surgery, particularly sleeve gastrectomy (SG), since the gastroesophageal junction (GEJ), depending on LGA, would be devascularized. Our aim was to evaluate, in an experimental animal study, an endovascular approach targeting arteries of the gastroepiploic arcade aiming to modulate ghrelin levels and to generate an increased vascular supply of the GEJ to reduce the risks of staple-line leaks after SG.
  
  
  METHODS
  Seven pigs underwent embolization of both left and right gastroepiploic arteries (LGEA and RGEA) using 500-700-μ microspheres (embolization of arterial gastric supply in obesity (EMBARGO)-alpha). A SG was performed in six pigs 3 weeks after EMBARGO-alpha and on eight controls. Capillary lactates were measured at the cardia and pylorus. Five pigs underwent coiling of RGEA and embolization of LGEA using both coils and 100-300-μ microspheres (EMBARGO-beta). Ghrelin levels were assessed before and once per week after both EMBARGOs. Control celiac trunk angiography was performed at 3 weeks (alpha) and 4 weeks (beta).
  
  
  RESULTS
  No significant ghrelin reduction was obtained with EMBARGO-alpha at 3 weeks when compared to baseline. Significant ghrelin reduction was found 3 weeks (p = 0.0363) and 4 weeks (p = 0.025) after EMBARGO-beta. Post-EMBARGO-alpha animals presented a significantly lower increase in cardia lactates when compared to controls after SG. Control angiography showed a significantly increased fundic vascular network in 5/6 animals after EMBARGO-alpha and in 5/5 after EMBARGO-beta.
  
  
  CONCLUSIONS
  EMBARGO is effective to decrease ghrelin production and can enhance the vascular supply of the GEJ, preparing the vascular background for a SG.
authors.affiliation: University Institute of Image-Guided Surgery, IHU-Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg, France, michele.diana@ircad.fr.
authors.forename: Michele
authors.initials: M
authors.lastname: Diana
authors.forename: Raoul
authors.initials: R
authors.lastname: Pop
authors.forename: Rémy
authors.initials: R
authors.lastname: Beaujeux
authors.forename: Bernard
authors.initials: B
authors.lastname: Dallemagne
authors.forename: Peter
authors.initials: P
authors.lastname: Halvax
authors.forename: Isabel
authors.initials: I
authors.lastname: Schlagowski
authors.forename: Yu-Yin
authors.initials: YY
authors.lastname: Liu
authors.forename: Pierre
authors.initials: P
authors.lastname: Diemunsch
authors.forename: Bernard
authors.initials: B
authors.lastname: Geny
authors.forename: Veronique
authors.initials: V
authors.lastname: Lindner
authors.forename: Jacques
authors.initials: J
authors.lastname: Marescaux
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000379:methods; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000379:methods*; D004943:Esophagogastric Junction / Q000098:blood supply; D005743:Gastrectomy; D054439:Ghrelin / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000628:therapy*; D013270:Stomach / Q000098:blood supply*; D034421:Sus scrofa
chemical_list: D054439:Ghrelin