title: Efficacy and safety of clearing heat and detoxifying injection in the treatment of influenza: a randomized, double-blinded, placebo-controlled trial.
abstract: Objective. To evaluate the efficacy and safety of CHDI in the treatment of influenza infection. Method. A randomized double-blind, double dummy trial was conducted. Influenza patients with a positive influenza A rapid test diagnosis were randomized to receive CHDI or oseltamivir. Primary outcome was assessed by the median fever alleviation time and clearance time, and secondary outcome was total scores of influenza symptoms. Results. One hundred thirty-nine participants were screened and 34 had a RT-PCR laboratory confirmation of influenza virus infection. Fever alleviation time was 2.5 and 5 hours in CHDI and oseltamivir, respectively, and fever clearance time was 32.5 and 49 hours. The HR of fever alleviation and clearance time shows no significant difference between two groups. Total scores of influenza symptoms descended significantly in both groups after treatment and descended more in CHDI than oseltamivir on day 2. Similar to total symptoms severity score, fever severity score descend more significantly in CHDI than oseltamivir on day 2, and there were no differences on other symptoms. Conclusions. CHDI have a similar effect to oseltamivir in reducing the duration of influenza illness. CHDI was well tolerated, with no serious adverse events noted during the study period.
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Baolin
authors.initials: B
authors.lastname: Wei
authors.affiliation: The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 314 Anshanxi Road, Naikai District, Tianjin 300193, China.
authors.forename: Xinqiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine, No. 100 Shizi Street, Hongshan Road, Nanjing 210028, China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, No. 54 Youdian Road, Shangyou District, Hangzhou 310006, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530011, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tan
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Zengtao
authors.initials: Z
authors.lastname: Sun