title: Is the use of negative pressure wound therapy for a malignant wound legitimate in a palliative context? "The concept of NPWT ad vitam": A case series.
abstract: BACKGROUND
  The management of malignant wounds remains particularly difficult. They are often malodorous, highly exuding, and painful. In this context, the use of negative pressure wound therapy is usually not recommended. It is, however, an effective procedure for maintaining a good quality of life in certain palliative situations.
  
  
  METHODS
  Five patients underwent negative pressure wound therapy for a malignant wound in our unit. Three had sarcomas, one patient had a parietal recurrence of breast carcinoma, and one patient had melanoma. They were in a metastatic palliative situation and were no longer receiving specific treatment.
  The patients reported a decrease in odor and exudates with negative pressure wound therapy, compared with conventional dressings. No patients complained of pain associated with the suction system itself. Fewer dressing changes reduced the pain and encouraged the resumption of social interactions. The average duration of negative pressure wound therapy before the death of the patients was 49 days. No complications or bleeding were observed. The duration of the patients' stay was shortened by implementing negative pressure wound therapy at home.
  
  
  CONCLUSIONS
  We report on our experiences with five patients for whom manufacturers and health authorities contraindicated the use of negative pressure wound therapy because of its potential to encourage tumor growth, although it was considered to be beneficial for all of these patients. This procedure may offer an alternative to conventional wound dressings at the end of life and improve the quality of life of patients by controlling the three most disabling elements: the odor, exudate, and pain associated with changing the dressings. Miniaturization and lower costs could promote the systematic use of negative pressure wound therapy.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Toulouse CHU Rangueil, Toulouse, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Riot
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Toulouse CHU Rangueil-Larrey, Toulouse, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: de Bonnecaze
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Toulouse CHU Rangueil, Toulouse, France Universitary Institute of Cancer, Toulouse, France.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Garrido
authors.affiliation: Universitary Institute of Cancer, Toulouse, France.
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Ferron
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Toulouse CHU Rangueil, Toulouse, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Grolleau
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Toulouse CHU Rangueil, Toulouse, France Department of Otorhinolaryngology, Head and Neck Surgery, University of Toulouse CHU Rangueil-Larrey, Toulouse, France Universitary Institute of Cancer, Toulouse, France Benoitchaput31@gmail.com.
authors.forename: Benoit
authors.initials: B
authors.lastname: Chaput
mesh_terms: D001458:Bandages / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D009369:Neoplasms / Q000150:complications*; D009812:Odorants / Q000517:prevention & control; D010146:Pain / Q000517:prevention & control; D010166:Palliative Care / Q000379:methods*; D011788:Quality of Life; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology / Q000628:therapy*
keywords: Palliative wound; case series; negative pressure wound therapy; quality of life