title: Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
abstract: The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and β-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling capacity. Here we review the state of knowledge on this important virulence factor and acellular pertussis vaccine component. Specific emphasis is placed on outstanding questions that are yet to be answered.
authors.affiliation: Institute of Microbiology of the Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Villarino Romero
authors.forename: Radim
authors.initials: R
authors.lastname: Osicka
authors.forename: Peter
authors.initials: P
authors.lastname: Sebo
mesh_terms: D018829:Adhesins, Bacterial / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology* / Q000472:pathogenicity*; D051928:CD47 Antigen / Q000378:metabolism; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D006801:Humans; D007155:Immunologic Factors; D010566:Virulence Factors, Bordetella / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D014917:Whooping Cough / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
chemical_list: D018829:Adhesins, Bacterial; D051928:CD47 Antigen; C497894:CD47 protein, human; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007155:Immunologic Factors; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis
keywords: Bordetella; adhesion; filamentous hemagglutinin; immunomudulation; integrins; pertussis; vaccine; virulence factors