title: Fluorescent polymeric assemblies as stimuli-responsive vehicles for drug controlled release and cell/tissue imaging.
abstract: Polymer assemblies with good biocompatibility, stimuli-responsive properties and clinical imaging capability are desirable carriers for future biomedical applications. Herein, we report on the synthesis of a novel anthracenecarboxaldehyde-decorated poly(N-(4-aminophenyl) methacryl amide-oligoethyleneglycolmonomethylether methacrylate) (P(MAAPAC-MAAP-MAPEG)) copolymer, comprising fluorescent chromophore and acid-labile moiety. This copolymer can assemble into micelles in aqueous solution and shows a spherical shape with well-defined particle size and narrow particle size distribution. The pH-responsive property of the micelles has been evaluated by the change of particle size and the controlled release of guest molecules. The intrinsic fluorescence property endows the micelles with excellent cell/tissue imaging capability. Cell viability evaluation with human hepatocellular carcinoma BEL-7402 cells demonstrates that the micelles are nontoxic. The cellular uptake of the micelles indicates a time-dependent behavior. The H22-tumor bearing mice treated with the micelles clearly exhibits the tumor accumulation. These multi-functional nanocarriers may be of great interest in the application of drug delivery.
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China. Fujian Provincial Key Laboratory of Fire Retardant Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Shirong
authors.initials: S
authors.lastname: Yu
authors.forename: Jie
authors.initials: J
authors.lastname: Mao
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Conghui
authors.initials: C
authors.lastname: Yuan
authors.forename: Ning
authors.initials: N
authors.lastname: He
authors.forename: Weiang
authors.initials: W
authors.lastname: Luo
authors.forename: Lizong
authors.initials: L
authors.lastname: Dai
mesh_terms: D000818:Animals; D016923:Cell Death; D045744:Cell Line, Tumor; D002470:Cell Survival; D003692:Delayed-Action Preparations; D004705:Endocytosis; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D057054:Molecular Imaging / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers