title: [Research progress of in vivo bioreactor as vascularization strategies in bone tissue engineering].
abstract: OBJECTIVE
  To review the application and research progress of in vivo bioreactor as vascularization strategies in bone tissue engineering.
  
  
  METHODS
  The original articles about in vivo bioreactor that can enhance vascularization of tissue engineered bone were extensively reviewed and analyzed.
  
  
  RESULTS
  The in vivo bioreactor can be created by periosteum, muscle, muscularis membrane, and fascia flap as well as biomaterials. Using in vivo bioreactor can effectively promote the establishment of a microcirculation in the tissue engineered bones, especially for large bone defects. However, main correlative researches, currently, are focused on animal experiments, more clinical trials will be carried out in the future.
  
  
  CONCLUSIONS
  With the rapid development of related technologies of bone tissue engineering, the use of in vivo bioreactor will to a large extent solve the bottleneck limitations and has the potential values for clinical application.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D019149:Bioreactors; D001842:Bone and Bones / Q000098:blood supply* / Q000166:cytology / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic; D010521:Periosteum; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials