title: [Henoch-Schönlein purpura with late-onset necrotising glomerulonephritis--a case report].
abstract: Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, while it is rare in adults. Typical clinical manifestations include palpable purpura without thrombocytopenia and/or coagulopathy, arthritis/arthralgia, abdominal pain, and/or renal involvement. In adulthood the disease tends to be more serious than in children, with renal manifestations developing over a period of several days to one month after initial symptoms. In this article we present a 22-year-old female patient with cutaneous vasculitis and arthralgia, in whom renal disease developed 8 weeks after disease onset with microscopic hematuria and proteinuria in urinalysis. Renal biopsy subsequently performed revealed focal necrotising glomerulonephritis with IgA deposits. The patient was treated with high dose methylprednisolone followed by gradual tapering, which induced complete remission of the disease. In conclusion, patients with HSP should be carefully monitored for systemic involvement, since serious renal disease can develop even as late as two months after disease onset.
authors.forename: Joško
authors.initials: J
authors.lastname: Mitrović
authors.forename: Silva
authors.initials: S
authors.lastname: Pukšić
authors.forename: Ivica
authors.initials: I
authors.lastname: Horvatić
authors.forename: Vesna Sredoja
authors.initials: VS
authors.lastname: Tišma
authors.forename: Stela
authors.initials: S
authors.lastname: Bulimbašić
authors.forename: Jadranka
authors.initials: J
authors.lastname: Morović-Vergles
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000188:drug therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D013997:Time Factors; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D008775:Methylprednisolone