title: Posterior pole retinal abnormalities in mild asymptomatic FEVR.
abstract: OBJECTIVE
  To describe the posterior retinal abnormalities in asymptomatic mild familial exudative vitreoretinopathy (FEVR) individuals who are normal in conventional clinical examination.
  
  
  METHODS
  Thirty-eight asymptomatic mild FEVR individuals (38 eyes) and 38 controls (38 eyes) were included in this cross-sectional study. The posterior retinas in each individual appeared normal. The diagnosis of FEVR was made based on a positive FEVR family history and the presence of retinal peripheral avascular zone with other vessel abnormalities. Biometric data from fundus photographs and fluorescein fundus angiography of all subjects were studied. The diameter of the optic disc (DD), the disc-to-macula distance (DM), the ratio of DM/DD, and numbers of retinal vessels radiated from the optic disc were measured.
  
  
  RESULTS
  Significant anatomic differences were identified in the eyes of patients with asymptomatic FEVR compared with those of the control subjects. In individuals with stage I or II FEVR, DD was smaller (1605.34 ± 250.60 vs. 1733.39 ± 163.79 μm), DM was larger (5434.08 ± 824.82 vs. 4696.29 ± 257.34 μm), and DM/DD was higher (3.49 ± 0.93 vs. 2.73 ± 0.28) than those of the controls. Peripapillary retinal vessels were increased significantly in FEVR compared with the controls (24.53 ± 3.10 vs. 21.39 ± 2.65).
  
  
  CONCLUSIONS
  Asymptomatic individuals with stage I or II FEVR had several abnormalities in the posterior pole noted with more retinal vessels, a significantly larger disc-to-macula distance as well as a remarkably smaller optic disc with a decreased horizontal diameter. These findings will facilitate the early diagnosis of FEVR and are important for adequate genetic counseling as well as the prevention and treatment of this disease.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Miner
authors.initials: M
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Andina
authors.initials: A
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D018450:Disease Progression; D015785:Eye Diseases, Hereditary; D000080345:Familial Exudative Vitreoretinopathies; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000473:pathology; D011379:Prognosis; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology; D014792:Visual Acuity
keywords: FEVR; image analysis; posterior retina