title: Coapplication of lidocaine and membrane-impermeable lidocaine derivative QX-222 produces divergent effects on evoked and spontaneous nociceptive behaviors in mice.
abstract: The present study was aimed at investigating the analgesic properties of a combination of lidocaine and QX-222 and its effects on evoked pain behavior (complete Freund's adjuvant-induced allodynia and hyperalgesia in inflammatory condition) and spontaneous pain behavior (formalin-induced acute pain) in mice. Drugs were injected adjacent to sciatic nerve or into plantar. Motor function, thermal withdrawal latency, mechanical withdrawal threshold, and licking/biting were evaluated by behavioral tests. A combination of lidocaine and QX-222 adjacent sciatic nerve injection produced the long-lasting sensory-specific nerve block, and intraplantar injection inhibited spontaneous pain in the formalin-treated mice but did not detectably attenuated hyperalgesia and allodynia in the complete Freund's adjuvant- (CFA-) treated mice. Our results suggest that a combination of lidocaine and QX-222 achieves a long-lasting differential block (sensory selective) and produces divergent effects on evoked and spontaneous pain behaviors in mice.
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Si-Ping
authors.initials: SP
authors.lastname: Hu
authors.affiliation: Department of Orthopedics, Huzhou Central Hospital, Hongqi Road No. 198, Huzhou 313000, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: He-Fen
authors.initials: HF
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: Jing-Bing
authors.initials: JB
authors.lastname: Gui
mesh_terms: D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004338:Drug Combinations; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D051379:Mice; D059225:Nociception / Q000187:drug effects; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D012584:Sciatic Nerve / Q000187:drug effects
chemical_list: D000700:Analgesics; D004338:Drug Combinations; C006072:QX-222; D008012:Lidocaine