title: Dendritic cells during Staphylococcus aureus infection: subsets and roles.
abstract: Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play a crucial role in both innate and adaptive immune responses. DCs orient the immune responses by modulating the balance between protective immunity to pathogens and tolerance to self-antigens. Staphylococcus aureus (S. aureus) is a common member of human skin microbiota and can cause severe infections with significant morbidity and mortality. Protective immunity to pathogens by DCs is required for clearance of S. aureus. DCs sense the presence of the staphylococcal components using pattern recognition receptors (PRRs) and then orchestrate immune systems to resolve infections. This review summarizes the possible roles of DCs, in particular their Toll-like receptors (TLRs) involved in S. aureus infection and strategies by which the pathogen affects activation and function of DCs.
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. wuxuejie81@163.com.
authors.forename: Xuejie
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. xufeng99@yahoo.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D016131:Lymphocyte Subsets; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000472:pathogenicity; D051193:Toll-Like Receptors / Q000276:immunology; D014774:Virulence
chemical_list: D051193:Toll-Like Receptors