title: Pediatric meningiomas an aggressive subset: a clinicopathological and immunohistochemical study.
abstract: BACKGROUND
  Meningiomas are uncommon neoplasms in the pediatric age group and differ in various aspects from their adult counterparts. They account for 0.4-4.6% of all primary brain tumors.
  
  
  OBJECTIVE
  To retrospectively analyze the clinicopathological and immunohistochemical features of pediatric meningiomas.
  
  
  METHODS
  Meningiomas in patients under 18 years of age diagnosed between January 2001 to December 2011 were analyzed retrospectively. The hematoxylin and eosin stained sections and Ki 67 labelling index (LI) were reviewed for all the cases Results: The pediatric meningiomas accounted for 1.52% of total meningiomas (15/983). The mean age at presentation was 12 years with male to female ratio of 1.5:1. The presenting symptoms were headache, seizures, and motor deficits. The histology included 9 cases (60%) of atypical meningioma (WHO grade II) followed by 4 cases (26.67%) of WHO grade-I and 2 cases (13.33%) of anaplastic meningioma (WHO grade III). Five cases had a recurrence. Ki67 LI ranged from 0.5% to 1.5% in grade I, 0.5% to 15% in grade II and 13% to 24% in grade III meningiomas.
  
  
  CONCLUSIONS
  Meningiomas are rare in children and show a male preponderance. There was a higher incidence of atypical and anaplastic meningiomas in pediatric population.
authors.forename: M
authors.initials: M
authors.lastname: Hui
authors.forename: M S
authors.initials: MS
authors.lastname: Uppin
authors.forename: M Vijaya
authors.initials: MV
authors.lastname: Saradhi
authors.forename: B P
authors.initials: BP
authors.lastname: Sahu
authors.forename: A K
authors.initials: AK
authors.lastname: Purohit
authors.affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
authors.forename: C
authors.initials: C
authors.lastname: Sundaram
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008579:Meningioma / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012189:Retrospective Studies; D017678:Sex Distribution
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen