title: IgA deficiency in wolves from Canada and Scandinavia.
abstract: Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in both humans and selected breeds of domestic dogs. In both species, IgAD is associated with recurrent infections and immune mediated diseases. Previous results imply that IgAD is also common in the wild ancestor of domestic dogs, the gray wolf. Here, we report that serum IgA concentrations are significantly different in Scandinavian and Canadian wolves (p = 3.252e-15) with an increased prevalence for IgAD in Scandinavian wolves (60%), which is as high as those found in high-risk dog breeds.
authors.affiliation: Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden.
authors.forename: Marcel
authors.initials: M
authors.lastname: Frankowiack
authors.affiliation: Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden.
authors.forename: Mia
authors.initials: M
authors.lastname: Olsson
authors.affiliation: Department of Environment and Natural Resources, Government of the Northwest Territories, Yellowknife, Northwest Territories, Canada.
authors.forename: H Dean
authors.initials: HD
authors.lastname: Cluff
authors.affiliation: Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Hedmark University College, Campus Evenstad, NO-2418 Elverum, Norway.
authors.forename: Alina L
authors.initials: AL
authors.lastname: Evans
authors.affiliation: Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Hellman
authors.affiliation: Department of Ecology, Faculty of Natural Resources and Agricultural Sciences, Swedish University of Agricultural Sciences, SE-730 91 Grimsö, Riddarhyttan, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Månsson
authors.affiliation: Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Hedmark University College, Campus Evenstad, NO-2418 Elverum, Norway; Department of Wildlife, Fish and Environmental Studies, Faculty of Forest Sciences, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden.
authors.forename: Jon M
authors.initials: JM
authors.lastname: Arnemo
authors.affiliation: Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden. Electronic address: lennart.hammarstrom@ki.se.
authors.forename: Lennart
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000818:Animals; D002170:Canada; D017098:IgA Deficiency / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D012537:Scandinavian and Nordic Countries; D019596:Wolves / Q000097:blood* / Q000145:classification / Q000235:genetics
keywords: Dog; IgA deficiency; Serum IgA concentrations; Wolf