title: Touraine-Solente-Gole syndrome in two siblings.
abstract: Hypertrophic Osteoarthropathy secondary to various causes is not a common entity but primary hypertrophic osteoarthropathy (also called Touraine-Solente-Gole Syndrome) is an extremely rare genetic disorder. It was first described in 1868 by Friedrich and has premier features of clubbing, periostosis and pachydermia. Based on clinical manifestations Touraine Solente and Gole distinguished it into three forms as complete, incomplete and fruste form. Most of the cases described up till now had onset in late adolescence. This report describes two siblings having symptoms consistent with Touraine-Solente-Gole Syndrome which had onset in early childhood.
authors.affiliation: Department of Paediatric Medicine, Children's Hospital and Institute of Child Health, Lahore.
authors.forename: Aisha
authors.initials: A
authors.lastname: Iftikhar
authors.affiliation: Department of Paediatric Medicine, Children's Hospital and Institute of Child Health, Lahore.
authors.forename: Muhammad Haroon
authors.initials: MH
authors.lastname: Hamid
authors.affiliation: Department of Paediatric Medicine, Children's Hospital and Institute of Child Health, Lahore.
authors.forename: Ahsan Waheed
authors.initials: AW
authors.lastname: Rathore
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002648:Child; D005260:Female; D005385:Fingers / Q000473:pathology*; D006801:Humans; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D035781:Siblings
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal