title: Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.
abstract: Metabotropic glutamate receptors (mGluRs) modulate neurotransmission all along the pain neuraxis. While the involvement of group I and group II mGluRs in pain is well documented, information has only just started to emerge concerning the role and contribution of group III mGluRs subtypes to pain modulation. Recent data suggest that these receptors reduce symptoms in animal models of chronic pain, as well as regulate neurotransmission at different levels of ascending and descending pain pathway, suggesting that group III mGluRs may be interesting therapeutic targets for the development of analgesics.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR8601, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: francine.acher@parisdescartes.fr.
authors.forename: Francine
authors.initials: F
authors.lastname: Acher
authors.affiliation: Institut de Génomique Fonctionnelle, CNRS UMR5203, Université de Montpellier, Montpellier, France; INSERM, U661, Montpellier, France. Electronic address: cyril.goudet@igf.cnrs.fr.
authors.forename: Cyril
authors.initials: C
authors.lastname: Goudet
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D059350:Chronic Pain / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008024:Ligands; D058990:Molecular Targeted Therapy; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D000700:Analgesics; D008024:Ligands; D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3