title: [Effects of myocardial performance index on assessing left ventricular function in patients with primary hypertension].
abstract: OBJECTIVE
  To investigate the value of myocardial performance index (MPI) in assessing LV function in patients with primary hypertension (HP).
  
  
  METHODS
  We studied 130 patients with HP (mean age 54.9±13.3 years)and 155 healthy control subjects (mean age 52.4±11.6 years). MPI was determined by tissue doppler imaging using the following formula: MPI=(isovolumic contraction time + isovolumic relaxation time)/ ejection time. The HP group was divided into hypertrophy subgroup( LVMI≥115 g/m(2) in males, or ≥95 g/m(2) in females) and normal mass subgroup(LVMI <115 g/m(2) in males, or<95 g/m(2) in females).
  
  
  RESULTS
  MPI was significantly different in control group, normal mass subgroup and hypertrophy subgroup(0.72±0.23 vs. 0.54± 0.17 vs. 0.45±0.11, P<0.001). Hypertrophy subgroup had significant higher MPI than normal mass subgroup(P =0.046), and both the groups had significant higher MPI than control group(all P<0.001). MPI was positively associated with age(r=0.369,P<0.001), Left ventricular end diastolic diameter(r=0.169, P<0.05), Sm(r=-0.211, P<0.001) and Em(r=-0.383, P<0.001) in control group. In multiple linear regression analysis, MPI was independently related to age (β=0.492, t=7.222,P<0.001) in control group. Among the HP patients, MPI was positively associated with left atrial area (r=0.293, P<0.001),intra ventricular septum(IVS) diameter (r=0.453, P<0.001), LVMI (r=0.453, P<0.001), relative wall thickness(r=0.458, P<0.001), and negatively associated with Sm(r=-0.414, P<0.001), Em(r=-0.508, P<0.001), left ventricular ejection fraction (r=-0.305, P<0.001) in bivariate analysis. In the multiple linear regression analysis, MPI was independently related to Em (β=0.401, t=4.256,P<0.001) and IVS diameter (β=-0.365, t=-3.878,P<0.001) in the HP patients.
  
  
  CONCLUSIONS
  The HP patients had elevated MPI, especially in the ones with LV hypertrophy. Tissue doppler imaging (TDI) derived MPI could be a useful index to evaluate the overall cardiac function in HP patients.
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: F F
authors.initials: FF
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: B X
authors.initials: BX
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Feng
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptide, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education, Beijing 100191, China.
authors.forename: W
authors.initials: W
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension; D017379:Hypertrophy, Left Ventricular; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D016277:Ventricular Function, Left