title: Healing efficacy and participant outcomes of chemical matrixectomies using a hydrogel containing oakin.
abstract: BACKGROUND
  We sought to demonstrate the healing efficacy of an antimicrobial hydrogel containing Oakin, an oak extract, to heal postoperative partial and total chemical matrixectomies.
  
  
  METHODS
  Sixty participants were eligible for this open-label prospective study by having an ingrown toenail and a willingness to have the ingrown portion of the nail or the entire toenail permanently removed. All of the participants underwent a similar nail surgery, were provided a postoperative kit that included the study hydrogel, and received the same sheet of instructions for aftercare.
  
  
  RESULTS
  Fifty-four participants could be contacted for follow-up and final evaluation; 54% (n = 29) were men and 46% (n = 25) were women. Eighty-nine partial hallux nail avulsions with phenol matrixectomy were performed. The median ± SD time to healing was 7.00 ± 0.00 days for 80% of participants (n =  43) and 8.85 ± 4.15 days for 98% (n = 53). An analysis of variance showed that the proportion healed time trend is significant (F1,53 = 79.265; P < .001).
  
  
  CONCLUSIONS
  The study hydrogel's ability to stop phenol's caustic activity is clinically beneficial in phenol matrixectomy aftercare. Providing each participant with a kit that included the same dressing supplies yielded consistent aftercare outcomes and 98% patient satisfaction (n = 53). The findings show that the Oakin-containing hydrogel was efficacious in healing phenol matrixectomies without the need for soaking. Furthermore, we suggest that the study hydrogel could also reduce healing times.
authors.forename: Kristina N
authors.initials: KN
authors.lastname: Barreiro
authors.forename: Masoud
authors.initials: M
authors.lastname: Moradi
authors.forename: Thomas
authors.initials: T
authors.lastname: Merrill
authors.forename: James
authors.initials: J
authors.lastname: Losito
authors.forename: Charles
authors.initials: C
authors.lastname: Southerland
authors.forename: Barbara
authors.initials: B
authors.lastname: Buckley
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D008875:Middle Aged; D009263:Nails, Ingrown / Q000601:surgery*; D017060:Patient Satisfaction; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014034:Toes; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000890:Anti-Infective Agents; C588008:Oakin; D010936:Plant Extracts; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate