title: Cerebral sinovenous thrombosis in neonatal antiphospholipid syndrome: a new entity?
abstract: Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production of de novo antibodies by the neonate. However, few cases of neonatal APS are reported in the literature, especially regarding arterial thrombotic events. In particular, only two cases of neonatal aPL related isolated cerebral sinovenous thrombosis (CSVT) are described in the literature. Despite its frequency, CSVT results in significant mortality and morbidity, probably also due to the difficulty in early diagnosis and then in correct managing in the neonatal period. A diagnosis of neonatal APS should be considered in the evaluation of neonates with CSVT, as well as in any case of neonatal thrombosis, to correctly manage the affected neonates and counsel the mother for future pregnancies.
authors.affiliation: Division of Neonatology, Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: De Carolis
authors.affiliation: Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of Sacred Heart, Rome Italy.
authors.forename: S
authors.initials: S
authors.lastname: Salvi
authors.affiliation: Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of Sacred Heart, Rome Italy.
authors.forename: A
authors.initials: A
authors.lastname: Botta
authors.affiliation: Division of Neonatology, Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cocca
authors.affiliation: Division of Rheumatology, Sapienza Universita' di Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Garufi
authors.affiliation: Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of Sacred Heart, Rome Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lanzone
authors.affiliation: Department of Obstetrics, Gynaecology and Paediatrics, Catholic University of Sacred Heart, Rome Italy sara.decarolis@rm.unicatt.it.
authors.forename: S
authors.initials: S
authors.lastname: De Carolis
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D020767:Intracranial Thrombosis / Q000276:immunology*; D008297:Male
keywords: Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulant; thrombosis