title: Retrospective Analysis of Cushing's Disease with or without Hyperprolactinemia.
abstract: Objective. We compared the characteristics of patients with Cushing's disease alone with those of patients with Cushing's disease and hyperprolactinemia. Methods. Eighty-four patients were enrolled between 2002 and 2011, in a hospital in China. Clinical, endocrinological, and histopathological data, MRI scans, and surgical outcomes were reviewed throughout the follow-up period. Results. Patients with Cushing's disease and hyperprolactinemia had a younger age at diagnosis (30.28 ± 14.23 versus 36.08 ± 10.91 years; P = 0.037) and a larger adenoma maximal diameter (2.44 ± 1.32 versus 1.44 ± 1.05 cm; P < 0.001) than patients with Cushing's disease alone. Menstrual disorders (P = 0.027) and visual field defects (P = 0.021) were more common and progressive obesity (P = 0.009) and hypertension (P < 0.001) were less common in patients with Cushing's disease and hyperprolactinemia. The rate of normalization of hormonal levels was lower (41.7% versus 91.7%; P < 0.001) and the recurrence rate was higher (36.1% versus 8.3%; P < 0.001) in patients with Cushing's disease and hyperprolactinemia. Conclusions. Careful long-term follow-up is needed of patients with Cushing's disease and hyperprolactinemia.
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.
authors.forename: Cheng
authors.identifier: 0000-0002-1212-6220
authors.initials: C
authors.lastname: Huan
authors.affiliation: Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.
authors.forename: Guang-Ming
authors.identifier: 0000-0002-1991-1176
authors.initials: GM
authors.lastname: Xu
authors.affiliation: Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.
authors.forename: Xin
authors.identifier: 0000-0003-2649-761X
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Qu