title: Composition and antioxidant activity of Senecio nudicaulis Wall. ex DC. (Asteraceae): a medicinal plant growing wild in Himachal Pradesh, India.
abstract: The composition of essential oil isolated from Senecio nudicaulis Wall. ex DC. growing wild in Himachal Pradesh, India, was analysed, for the first time, by capillary gas chromatography (GC) and GC-mass spectrometry. A total of 30 components representing 95.3% of the total oil were identified. The essential oil was characterised by a high content of oxygenated sesquiterpenes (54.97%) with caryophyllene oxide (24.99%) as the major component. Other significant constituents were humulene epoxide-II (21.25%), α-humulene (18.75%), β-caryophyllene (9.67%), epi-α-cadinol (2.90%), epi-α-muurolol (2.03%), β-cedrene (1.76%), longiborneol (1.76%), 1-tridecene (1.16%) and citronellol (1.13%). The oil was screened for antioxidant activity using DPPH, ABTS and nitric oxide-scavenging assay. The oil was found to exhibit significant antioxidant activity by scavenging DPPH, ABTS and nitric oxide radicals with IC50 values of 10.61 ± 0.14 μg mL(- 1), 11.85 ± 0.28 μg mL(- 1) and 11.29 ± 0.42 μg mL(- 1), respectively.
authors.affiliation: a Department of Chemistry , Kumaun University , SSJ Campus, Almora , Uttarakhand 263601 , India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
authors.forename: G C
authors.initials: GC
authors.lastname: Shah
mesh_terms: D000080462:Acyclic Monoterpenes; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D007194:India; D000081222:Monocyclic Sesquiterpenes; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification; D009822:Oils, Volatile / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000080462:Acyclic Monoterpenes; D000475:Alkenes; D000975:Antioxidants; D000081222:Monocyclic Sesquiterpenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C445364:cadinol; C000393:cedrene; C412581:longiborneol; C042686:humulene; C028691:1-tridecene; C024714:caryophyllene; C007078:citronellol; C515179:caryophyllene oxide
keywords: Senecio nudicaulis; antioxidant activity; caryophyllene oxide; essential oil composition; humulene epoxide-II