title: Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in Parkinson's Disease?
abstract: Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has separate items for measuring sleep problems (item 1.7) and daytime sleepiness (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the PD Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 PD patients were enrolled. Spearman's rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lin's Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the "disturbed sleep" domain of PDSS-2 showed high correlation with "sleep problems" item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with "daytime sleepiness" item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both sleep problems and daytime sleepiness and identifies subjects whose disabilities need further investigation.
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Krisztina
authors.identifier: 0000-0002-2778-1121
authors.initials: K
authors.lastname: Horváth
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Aschermann
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Acs
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Bosnyák
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Deli
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Endre
authors.initials: E
authors.lastname: Pál
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary ; MTA-PTE Clinical Neuroimaging Research Group, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Béla
authors.identifier: 0000-0003-2126-4243
authors.initials: B
authors.lastname: Faludi
authors.affiliation: Unified Health Centers of the City of Pécs, Dr. Veress Endre Utca 2, Pécs 7633, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Késmárki
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary.
authors.forename: Sámuel
authors.initials: S
authors.lastname: Komoly
authors.affiliation: Department of Neurology, Nyirő Gyula Hospital-National Institute of Psychiatry and Addictology, Dévai Utca 15a, Budapest, Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Bokor
authors.affiliation: Department of Neurology, Nyirő Gyula Hospital-National Institute of Psychiatry and Addictology, Dévai Utca 15a, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Rigó
authors.affiliation: Department of Neurology, Kenézy Gyula Hospital, Bartók Béla Utca 2-26, Debrecen, Hungary.
authors.forename: Júlia
authors.initials: J
authors.lastname: Lajtos
authors.affiliation: Department of Neurology, University of Szeged, Semmelweis Utca 6, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Klivényi
authors.affiliation: Department of Neurology, University of Szeged, Semmelweis Utca 6, Szeged, Hungary.
authors.forename: György
authors.identifier: 0000-0002-7245-1439
authors.initials: G
authors.lastname: Dibó
authors.affiliation: Department of Neurology, University of Szeged, Semmelweis Utca 6, Szeged, Hungary ; MTA-SZTE Neuroscience Research Group, Semmelweis Utca 6, Szeged, Hungary.
authors.forename: László
authors.identifier: 0000-0001-8037-3672
authors.initials: L
authors.lastname: Vécsei
authors.affiliation: Department of Neurology, Semmelweis University, Balassa Utca 6, Budapest, Hungary.
authors.forename: Annamária
authors.initials: A
authors.lastname: Takáts
authors.affiliation: Department of Neurology, Semmelweis University, Balassa Utca 6, Budapest, Hungary.
authors.forename: Adrián
authors.initials: A
authors.lastname: Tóth
authors.affiliation: Department of Neurology, Csolnoky Ferenc Hospital, Kórház Utca 1, Veszprém, Hungary.
authors.forename: Piroska
authors.initials: P
authors.lastname: Imre
authors.affiliation: Department of Neurology, Kaposi Mór Hospital, Tallián Gyula Utca 20-32, Kaposvár 7400, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Nagy
authors.affiliation: Department of Neurology, Kaposi Mór Hospital, Tallián Gyula Utca 20-32, Kaposvár 7400, Hungary.
authors.forename: Mihály
authors.initials: M
authors.lastname: Herceg
authors.affiliation: National Institute of Clinical Neuroscience, Amerikai Utca 57, Budapest, Hungary.
authors.forename: Anita
authors.identifier: 0000-0001-9860-730X
authors.initials: A
authors.lastname: Kamondi
authors.affiliation: Department of Neurology, University of Debrecen, Móricz Zsigmond Körút 22, Debrecen, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Hidasi
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7633, Hungary ; MTA-PTE Clinical Neuroimaging Research Group, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Norbert
authors.identifier: 0000-0002-7332-9240
authors.initials: N
authors.lastname: Kovács