title: CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry.
abstract: We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) and thrombus (10%) were exclusively seen in PAH-congenital heart disease. Oesophageal dilation (46%) was most frequent in PAH-systemic sclerosis. Ground glass opacification (GGO) (41%), pericardial effusion (38%), lymphadenopathy (19%) and pleural effusion (11%) were common. On multivariate analysis, inferior vena caval area, the presence of pleural effusion and septal lines predicted outcome. In PAH, CTPA provides diagnostic and prognostic information. In addition, the presence of GGO on a CT performed for unexplained breathlessness should alert the physician to the possibility of PAH.
authors.affiliation: Academic Unit of Radiology, University of Sheffield, Sheffield, UK.
authors.forename: S
authors.initials: S
authors.lastname: Rajaram
authors.affiliation: Academic Unit of Radiology, University of Sheffield, Sheffield, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Swift
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit and Academic Department of Respiratory Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: R
authors.initials: R
authors.lastname: Condliffe
authors.affiliation: Academic Unit of Radiology, University of Sheffield, Sheffield, UK.
authors.forename: C
authors.initials: C
authors.lastname: Johns
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit and Academic Department of Respiratory Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Elliot
authors.affiliation: Department of Radiology, Sheffield Teaching Hospitals, UK.
authors.forename: C
authors.initials: C
authors.lastname: Hill
authors.affiliation: Department of Radiology, Sheffield Teaching Hospitals, UK.
authors.forename: C
authors.initials: C
authors.lastname: Davies
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit and Academic Department of Respiratory Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hurdman
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit and Academic Department of Respiratory Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: I
authors.initials: I
authors.lastname: Sabroe
authors.affiliation: Academic Unit of Radiology, University of Sheffield, Sheffield, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Wild
authors.affiliation: Sheffield Pulmonary Vascular Disease Unit and Academic Department of Respiratory Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Kiely
mesh_terms: D000328:Adult; D000368:Aged; D001027:Aortography / Q000379:methods; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000000981:diagnostic imaging; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D012042:Registries; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Primary Pulmonary Hypertension