title: [Role of receptor for advanced glycation end-products in pathgenesis of psoriasis].
abstract: This review summarizes the existing knowledge regarding the role of receptor for advanced glycation end products which is a key participant of the inflammatory process, in pathogenesis of psoriasis. By interacting with multiple ligands and activating several signaling mechanisms, receptor for advanced glycation end products regulates gene expression via a group transcription factors, that includes NFKB and AP1. According to the published data the expression of receptor for advanced glycation end products in both immune cells and their targets, a high stability of this receptor in complexes with ligands as well as a positive feedback loop, upregulating the expression of its certain ligands, suggest receptor for advanced glycation end products as a possible principal factor that makes the inflammatory response in psoriasis sustainable. Considering receptor for advanced glycation end products as a potential master regulator of several processes that play a crucial role in development of psoriatic plaques, we believe that further experimental studies are needed to elucidate how exactly this receptor converts a transient inflammatory reaction to a sustainable inflammatory response. These studies are also needed for the development of novel medications that target receptor for advanced glycation end products and signaling mechanisms that this receptor activates.
authors.forename: A G
authors.initials: AG
authors.lastname: Soboleva
authors.forename: S A
authors.initials: SA
authors.lastname: Bruskin
authors.forename: A A
authors.initials: AA
authors.lastname: Nikolaev
authors.forename: V V
authors.initials: VV
authors.lastname: Sobolev
authors.forename: A V
authors.initials: AV
authors.lastname: Mezentsev
mesh_terms: D025461:Feedback, Physiological; D005786:Gene Expression Regulation; D017127:Glycation End Products, Advanced / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D008024:Ligands; D016328:NF-kappa B / Q000096:biosynthesis / Q000378:metabolism; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D017127:Glycation End Products, Advanced; D008024:Ligands; D016328:NF-kappa B; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic