title: Wernicke encephalopathy in children and adolescents.
abstract: BACKGROUND
  Wernicke encephalopathy is caused by thiamine (vitamin B1) deficiency. It is generally considered to be a disease of adult alcoholics. However, it is known to occur in the pediatric population and in non-alcoholic conditions.
  
  
  METHODS
  We searched PubMed with the key words Wernicke, thiamine, pediatric, children and adolescents and selected publications that were deemed appropriate.
  
  
  RESULTS
  The global prevalence rates of hunger, poverty and resultant nutrient deprivation have decreased in the 21st century. However, several scenarios which may predispose to Wernicke encephalopathy may be increasingly prevalent in children and adolescents such as malignancies, intensive care unit stays and surgical procedures for the treatment of obesity. Other predisposing conditions include magnesium deficiency and defects in the SLC19A3 gene causing thiamine transporter-2 deficiency. The classic triad consists of encephalopathy, oculomotor dysfunction and gait ataxia but is not seen in a majority of patients. Treatment should be instituted immediately when the diagnosis is suspected clinically without waiting for laboratory confirmation. Common magnetic resonance findings include symmetric T2 hyperintensities in dorsal medial thalamus, mammillary bodies, periaqueductal gray matter, and tectal plate.
  
  
  CONCLUSIONS
  Wernicke encephalopathy is a medical emergency. Delay in its recognition and treatment may lead to significant morbidity, irreversible neurological damage or even death. This article aims to raise the awareness of this condition among pediatricians.
authors.affiliation: Division of Neurology, Children's Hospital Los Angeles, Los Angeles, California, USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Lallas
authors.forename: Jay
authors.initials: J
authors.lastname: Desai
mesh_terms: D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D013831:Thiamine / Q000627:therapeutic use; D014899:Wernicke Encephalopathy
chemical_list: D013831:Thiamine