title: [Effect of iodine-containing thyroid hormones on the histostructure of rat liver under the stress].
abstract: Experiments with 130 outbred male rats weighing 220-250 g have show that stress "free swimming in a cage" (FSC) affects the histological structure of the liver as early as in 1 h. FSC occurred in standard plastic cages (5 animals) filled with water to a height of 15 cm and topped with a grid. One hour after FSC (the alarm-stage) caused dystrophy of hepatocytes and increased blood flow to the liver lobules, which also continued at the resistance-stage (48 h after the FSC). At the exhaustion-stage (daily 1-hour stress for 10 days) there were even greater hepatocytes dystrophy, necrosis, and their microcirculatory disturbances in the lobules. The introduction of merkazolil (intragastrically 25 mg/kg for 20 days) per se altered the histostructure of the liver tissue and under stress aggravates the microcirculatory changes, dystrophy and necrosis of the hepatocytes. Small doses of L-thyroxine (intragastrically 1.5-3.0 μg/kg for 28 days) minimized the histological signes of the liver damage at all stages of the stress response. Consequently, the iodine-containing thyroid hormones limit the disturbance of the microstructure of the liver caused by stress.
authors.forename: I V
authors.initials: IV
authors.lastname: Gorodetskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Gusakova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D013956:Antithyroid Agents / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D009336:Necrosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013312:Stress, Physiological; D013550:Swimming; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole; D013974:Thyroxine