title: Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels.
abstract: OBJECTIVE
  This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis.
  
  
  METHODS
  Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included neonates with milder obstruction; and group 3 included neonates with normal findings on postnatal ultrasonography.
  
  
  RESULTS
  59 neonates were enrolled. The EGF: Cr and KIM-1: Cr ratios were significantly higher in group 1 than in group 2 (p = 0.016 and 0.015, respectively). The cut-off values were measured as 16.855 (sensitivity 71%, specificity 77%) and 0.4765 (sensitivity 81%, specificity 71%) for EGF:Cr and KIM-1:Cr ratios, respectively. The values were significantly higher in group 1 than in group 2.
  
  
  CONCLUSIONS
  Evaluation of the urinary KIM-1:Cr ratio may help identify neonates with severe obstructive hydronephrosis.
authors.affiliation: Antimicrobial Resistant Nosocomial Infection Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Mohammadjafari
authors.forename: Alireza
authors.initials: A
authors.lastname: Rafiei
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Kosaryan
authors.forename: Yalda
authors.initials: Y
authors.lastname: Yeganeh
authors.forename: Seyed Jalal
authors.initials: SJ
authors.lastname: Hosseinimehr
mesh_terms: D015415:Biomarkers / Q000652:urine; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital* / Q000175:diagnosis / Q000473:pathology / Q000652:urine; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine*; D021782:Multicystic Dysplastic Kidney / Q000175:diagnosis / Q000473:pathology / Q000652:urine*; D011991:Receptors, Virus; D012720:Severity of Illness Index; D014517:Ureteral Obstruction / Q000175:diagnosis / Q000473:pathology / Q000652:urine*
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D004815:Epidermal Growth Factor
keywords: EGF; KIM 1; UPJO; UVJO; antenatal hydronephrosis; urinary obstruction