title: Tranexamic acid for the management of uterine fibroid tumors: A systematic review of the current evidence.
abstract: OBJECTIVE
  To conduct a detailed systematic review of the current evidence on the administration and efficacy of tranexamic acid in patients with menorrhagia due to uterine fibroids.
  
  
  METHODS
  We conducted an electronic search on the following databases PubMed and Medline (1950-2013); (1980-2013); Cochrane library (1993-2013).
  
  
  RESULTS
  A total of 36 articles were retrieved after the initial electronic search. Careful assessment of the retrieved studies led to the final selection of 5 articles for inclusion in the review.
  
  
  CONCLUSIONS
  Tranexamic acid may reduce blood loss perioperatively in myomectomies. It may reduce the menorrhagia in patients with fibroids, however a stratification of fibroids by size and location is required to define the responses. It is safe in general, with mild adverse effects observed in some cases. More studies with a double-blind randomized design and larger numbers of participants are necessary to reach more precise and safe conclusions.
authors.affiliation: Panagiotis Peitsidis, Department of Obstetrics and Gynecology, Southend University Hospital, Essex SS0 0RY, United Kingdom.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Peitsidis
authors.affiliation: Panagiotis Peitsidis, Department of Obstetrics and Gynecology, Southend University Hospital, Essex SS0 0RY, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Koukoulomati
keywords: Fibrinolysis; Menorrhagia; Myomectomy; Tranexamic acid; Uterine fibroids