title: Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors.
abstract: BACKGROUND
  Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A.
  
  
  METHODS
  We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies.
  
  
  CONCLUSIONS
  Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning.
authors.forename: Danko
authors.initials: D
authors.lastname: Milošević
authors.forename: Ernest
authors.initials: E
authors.lastname: Bilić
authors.forename: Danica
authors.initials: D
authors.lastname: Batinić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Poropat
authors.forename: Ranka
authors.initials: R
authors.lastname: Štern-Padovan
authors.forename: Slobodan
authors.initials: S
authors.lastname: Galić
authors.forename: Daniel
authors.initials: D
authors.lastname: Turudić
mesh_terms: D019774:Blood Coagulation Factor Inhibitors / Q000378:metabolism; D002648:Child; D005164:Factor IX / Q000037:antagonists & inhibitors*; D015942:Factor VIIa / Q000009:adverse effects*; D006417:Hematuria / Q000097:blood / Q000188:drug therapy; D002836:Hemophilia B / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects; D013923:Thromboembolism / Q000139:chemically induced*
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D011994:Recombinant Proteins; D005164:Factor IX; C103587:recombinant FVIIa; D015942:Factor VIIa