title: Impact of cyclodextrins on postprandial glycemia: evaluation in experimental animal model using the real-time continuous glucose monitoring system.
abstract: The impact of cyclodextrins (CDs) on postprandial glycemic response employing the real-time continuous glucose monitoring system (RT-CGMS) was investigated. For this purpose, α-CD, β-CD, γ-CD, HP-β-CD, curdlan, and dextrin at doses of 10 and 100 mg/kg were orally administered in rats. The RT-CGMS was efficient to evaluate the impact of CDs on postprandial glycemia. The results showed that α-CD, β-CD, dextrin, and curdlan did not reduce the glycemic response after the administration of starch. In contrast, the HP-β-CD (100 mg/kg) attenuated the rise in glycemia. Moreover, the γ-CD blunts the postprandial glycemic excursion at doses of 10 and 100 mg/kg. Therefore, γ-CD could attenuate the rise in glycemia promoted by oral administration of starch. Considering that the treatment of postprandial hyperglycemia is necessary to prevent type 2 diabetes, this study opens the perspective of better control of postprandial glycemia by the addition of γ-CD in food.
authors.affiliation: 1Department of Pharmacy, State University of Maringá (UEM), Maringá, Paraná, Brazil.
authors.forename: Mauricio Fumio
authors.initials: MF
authors.lastname: Sybuia
authors.affiliation: 2Department of Pharmacology and Therapeutic, State University of Maringá (UEM), Maringá, Paraná, Brazil.
authors.forename: Márcio
authors.initials: M
authors.lastname: Guilhermetti
authors.affiliation: 3Food Science Program, State University of Maringá (UEM), Maringá, Paraná, Brazil.
authors.forename: Camila Sampaio
authors.initials: CS
authors.lastname: Mangolim
authors.affiliation: 2Department of Pharmacology and Therapeutic, State University of Maringá (UEM), Maringá, Paraná, Brazil.
authors.forename: Roberto Barbosa
authors.initials: RB
authors.lastname: Bazotte
authors.affiliation: 1Department of Pharmacy, State University of Maringá (UEM), Maringá, Paraná, Brazil.
authors.forename: Graciette
authors.initials: G
authors.lastname: Matioli
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003505:Cyclodextrins / Q000494:pharmacology / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control; D006943:Hyperglycemia / Q000097:blood / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D023421:Models, Animal; D008991:Monitoring, Physiologic / Q000379:methods; D019518:Postprandial Period; D017208:Rats, Wistar; D013213:Starch / Q000097:blood; D047392:beta-Cyclodextrins / Q000494:pharmacology / Q000627:therapeutic use; D047408:gamma-Cyclodextrins / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D003505:Cyclodextrins; D007004:Hypoglycemic Agents; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D013213:Starch
keywords: acarbose; cyclic oligosaccharides; glycemic control; postprandial glycemic response