title: In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.
abstract: An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.
authors.affiliation: Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Jenaro de la Fuente s/n, 15782, Santiago de Compostela, Spain. ef.megia@usc.es.
authors.forename: Ana
authors.initials: A
authors.lastname: Sousa-Herves
authors.forename: Christian
authors.initials: C
authors.lastname: Sánchez Espinel
authors.forename: Amir
authors.initials: A
authors.lastname: Fahmi
authors.forename: África
authors.initials: Á
authors.lastname: González-Fernández
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernandez-Megia
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D019187:Cadmium Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010587:Phagocytosis / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D001672:Biocompatible Materials; D019187:Cadmium Compounds; D050091:Dendrimers; D018036:Selenium Compounds; D011092:Polyethylene Glycols; D006046:Gold; C058667:cadmium selenide