title: Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
abstract: BACKGROUND
  A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis.
  
  
  METHODS
  Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA.
  
  
  RESULTS
  Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer.
  
  
  CONCLUSIONS
  Our meta- analysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.
authors.affiliation: Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China E-mail : cyz0515@sina.com, lifeng7855@126.com.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Cui
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.forename: Su
authors.initials: S
authors.lastname: Li
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Li
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Liu
authors.forename: Shu-Mao
authors.initials: SM
authors.lastname: Zhang
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Jin
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Hu
authors.forename: Jin-Fang
authors.initials: JF
authors.lastname: Jiang
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Liang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yun-Zhao
authors.initials: YZ
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002299:Cardia / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D020022:Genetic Predisposition to Disease; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D054801:Phosphoinositide Phospholipase C / Q000096:biosynthesis* / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D041742:Upper Gastrointestinal Tract / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon