title: Graphene oxide interfaces in serum based autoantibody quantification.
abstract: A reliable quantification of protein markers will undoubtedly underpin profound developments in disease surveillance, diagnostics, and improved therapy. Although there potentially exist numerous means of achieving this, electrochemical impedimetric techniques offer scale of sensitivity, cost, convenience, and a flexibility with which few alternatives can compete. Though there have been marked developments in electroanalytical protein detection, the demands associated with accessing the inherent assay sensitivity in complex biological media largely remains. We report herein the use of cysteamine-graphene oxide modified gold microelectrode arrays in underpinning the ultrasensitive and entirely label free non-faradaic quantification of Parkinson's-relevant autoantibodies in human serum.
authors.affiliation: Department of Chemistry, University of Oxford , Oxford, OX1 3QZ, United Kingdom.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Xu
authors.forename: Ho
authors.initials: H
authors.lastname: Cheng
authors.forename: Joshua
authors.initials: J
authors.lastname: Lehr
authors.forename: Amol V
authors.initials: AV
authors.lastname: Patil
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Davis
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015374:Biosensing Techniques / Q000379:methods*; D003543:Cysteamine / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008839:Microelectrodes; D010300:Parkinson Disease; D051844:alpha-Synuclein / Q000032:analysis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D051844:alpha-Synuclein; D003543:Cysteamine; D006046:Gold; D006108:Graphite