title: Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?
abstract: Metabolic reprogramming is a characteristic of cancer cells. Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit.
authors.affiliation: Barts Cancer Institute, Queen Mary University of London, Centre for Molecular Oncology, John Vane Science Centre, London EC1M 6BQ, UK. Electronic address: p.w.szlosarek@qmul.ac.uk.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Szlosarek
authors.affiliation: Cancer Biology and Metabolism Group, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.
authors.forename: SukJun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Cancer Biology and Metabolism Group, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address: patrickjohnpollard@gmail.com.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Pollard
mesh_terms: D001692:Biological Transport; D006019:Glycolysis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019289:Pyruvic Acid / Q000378:metabolism*
chemical_list: D019289:Pyruvic Acid