title: PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected].
abstract: OBJECTIVE
  Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG).
  
  
  METHODS
  Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls.
  
  
  RESULTS
  PSCA rs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCA rs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223.
  
  
  CONCLUSIONS
  Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Juozas
authors.initials: J
authors.lastname: Kupcinskas
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wex
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Link
authors.affiliation: Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Ruta
authors.initials: R
authors.lastname: Bartuseviciute
authors.affiliation: Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Milda
authors.initials: M
authors.lastname: Dedelaite
authors.affiliation: Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Gintare
authors.initials: G
authors.lastname: Kevalaite
authors.affiliation: Faculty of Medicine, University of Latvia, Riga, Latvia Digestive Diseases Center GASTRO, Riga, Latvia Riga East University Hospital, Riga, Latvia.
authors.forename: Marcis
authors.initials: M
authors.lastname: Leja
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Jurgita
authors.initials: J
authors.lastname: Skieceviciene
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Gediminas
authors.initials: G
authors.lastname: Kiudelis
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Laimas
authors.initials: L
authors.lastname: Jonaitis
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania l.kupcinskas@gmail.com.
authors.forename: Limas
authors.initials: L
authors.lastname: Kupcinskas
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D005756:Gastritis / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011230:Precancerous Conditions / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009363:Neoplasm Proteins; C110843:PSCA protein, human; D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon
keywords: MUC1; PLCE1; PSCA; SNP; gastric cancer; gastritis; gene polymorphism