title: Primary intracranial Parachordoma: An unusual tumor in brain.
abstract: BACKGROUND
  Parachordomas are rare soft tissue tumors commonly occurring in limbs, chest, Abdomen, and back. The World Health Organization (WHO) classification includes parachordomas in the same group as mixed tumors and myoepitheliomas. Exact histogenesis of this tumor is unclear.
  
  
  METHODS
  A 52-year-old male presented with headache and blurring of vision since one month. Preoperative computed tomography (CT) scan of brain revealed left parieto-occipital tumor extending up to the trigone. Total excision of the tumor was done. Histopathologically, the tumor was composed of relatively uniform cells with eosinophilic cytoplasm in a myxoid stroma and with cartilaginous and osseous metaplasia. The tumoral cells were immunoreactive for cytokeratin, epithelial membrane antigen (EMA), S-100, and vimentin. The constellation of findings revealed the tumor to be parachordoma. Magnetic resonance imaging (MRI) brain during follow-up at one year showed no recurrent tumor. No adjuvant therapy was given to this patient.
  
  
  CONCLUSIONS
  This is the first reported case of primary intracranial parachordoma. It is difficult to diagnose the lesion preoperatively by imaging alone. Long-term follow-up is necessary in view of few reports in literature of recurrence and metastasis, of parachordomas in other anatomical locations.
authors.affiliation: Department of Neurosurgery, Suraksha Hospital, Vijayawada, India.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Ghanta
authors.affiliation: Department of Pathology, Nizams institute of Medical sciences (NIMS), Hyderabad, India.
authors.forename: Megha S
authors.initials: MS
authors.lastname: Uppin
authors.affiliation: Department of Pathology, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation (Dr PSIMS and RF), Chinaoutpally, Krishna District, Andhra Pradesh, India.
authors.forename: Kalyan
authors.initials: K
authors.lastname: Koti
authors.affiliation: Department of Pathology, Nizams institute of Medical sciences (NIMS), Hyderabad, India.
authors.forename: Monalisa
authors.initials: M
authors.lastname: Hui
authors.affiliation: Department of Pathology, Nizams institute of Medical sciences (NIMS), Hyderabad, India.
authors.forename: Shantveer G
authors.initials: SG
authors.lastname: Uppin
authors.affiliation: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Kanchan K
authors.initials: KK
authors.lastname: Mukherjee
keywords: Brain tumor; brain; intracranial parachordoma; parachordoma