title: Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats.
abstract: The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a ) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu, Daegu 705-718, Republic of Korea.
authors.forename: Gi-Young
authors.initials: GY
authors.lastname: Park
authors.affiliation: Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu, Daegu 705-718, Republic of Korea.
authors.forename: Dong Rak
authors.identifier: 0000-0003-4728-930X
authors.initials: DR
authors.lastname: Kwon
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Won Sik
authors.initials: WS
authors.lastname: Seo
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Jeong Cheol
authors.initials: JC
authors.lastname: Shin
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Sang Hoon
authors.identifier: 0000-0001-8660-884X
authors.initials: SH
authors.lastname: Joo
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Kwon-Yeon
authors.initials: KY
authors.lastname: Weon
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.affiliation: Department of Cardiovascular and Neurologic Diseases, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
authors.forename: Kyung Min
authors.identifier: 0000-0002-9898-7987
authors.initials: KM
authors.lastname: Baek
authors.affiliation: Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Upadhyay
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Bing Tian
authors.initials: BT
authors.lastname: Zhao
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406-840, Republic of Korea.
authors.forename: So Hee
authors.initials: SH
authors.lastname: Kwon
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Beom Soo
authors.identifier: 0000-0002-6706-5445
authors.initials: BS
authors.lastname: Shin