title: Role of gamma-delta (γδ) T cells in autoimmunity.
abstract: γδ T cells represent a small population of overall T lymphocytes (0.5-5%) and have variable tissue distribution in the body. γδ T cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of γδ T cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between γδ T cells and other immune cells and phenotypic and functional plasticity of γδ T cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of γδ T cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.
authors.affiliation: National Centre for Cell Science, Pune University Campus, Pune, India.
authors.forename: Sourav
authors.initials: S
authors.lastname: Paul
authors.affiliation: National Centre for Cell Science, Pune University Campus, Pune, India.
authors.lastname: Shilpi
authors.affiliation: National Centre for Cell Science, Pune University Campus, Pune, India glal@nccs.res.in.
authors.forename: Girdhari
authors.initials: G
authors.lastname: Lal
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity; D006801:Humans; D007157:Immunologic Surveillance; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Th17; inflammation; intraepithelial lymphocyte; multiple sclerosis