title: One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip.
abstract: A DNA molecule was utilized as a probe tip to achieve single-molecule genetic diagnoses. Hybridization of the probe and target DNAs resulted in electron tunneling along the emergent double-stranded DNA. Simple stationary monitoring of the tunneling current leads to single-molecule DNA detection and discovery of base mismatches and methylation.
authors.affiliation: Department of Materials Science, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan.
authors.forename: Phuc Tan
authors.initials: PT
authors.lastname: Bui
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiigi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nagaoka
mesh_terms: D020137:Base Pair Mismatch; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000235:genetics*; D006147:Guanine; D009154:Mutation; D036103:Nanotechnology; D011687:Purines / Q000737:chemistry*; D011742:Pyrimidine Nucleotides / Q000032:analysis* / Q000235:genetics*
chemical_list: D011687:Purines; D011742:Pyrimidine Nucleotides; D006147:Guanine; D004247:DNA