title: Synthesis and fungistatic activity of aryl aldoxime derivatives.
abstract: OBJECTIVE
  The antifungal activity of 13 arylaldoxime ester and ether derivatives was tested against 4 dermatophytes Trichophyton mentagrophytes (TM), Microsporum canis (MC); M. cookei, and M. gypseum.
  
  
  METHODS
  Structures of all new compounds prepared from aryl aldehydes were established by spectral means. The tests were performed on the Sabouraud Dextrose Agar (SDA) substrate. The sensitivity of the dermatophyte strains towards oxime derivatives was established by determining MIC and MFC values.
  
  
  RESULTS
  The tested compounds showed a moderate fungicidal activity reaching 100% inhibition rate at 1% concentration. The activity against M. canis of 4 derivatives was higher than the activity of a reference drug clotrimazole.
  
  
  CONCLUSIONS
  A novel group of biologically active compounds was introduced. Simple aldoxime derivatives can be developed into a new class of antifungals.
authors.affiliation: Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland. Electronic address: golebiewski@ipo.waw.pl.
authors.forename: W
authors.initials: W
authors.lastname: Marek Gołębiewski
authors.affiliation: Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Cyrta
authors.affiliation: Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Michalczyk
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003883:Arthrodermataceae / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects / Q000254:growth & development; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D010091:Oximes; C023728:acetaldehyde oxime
keywords: Dermatophytes; Esters d’oximes; Fongicides; Fungicides; La lipophilie; Les dermatophytes; Lipophilicity; Oxime esters; Oxime ethers; Éthers d’oximes