title: [Antisense oligodeoxynucleotide therapy for castration-resistant prostate cancer].
abstract: Because of recent advances in the field of nucleic-acid chemistry, antisense oligodeoxynucleotide (AS ODN) technology can offer an attractive strategy to specifically inhibit expression of target genes causing a wide variety of diseases, including cancers. In prostate cancer (PC), several genes, involved in the acquisition of castration-resistant (CR) phenotype, have been identified, some of which, such as clusterin and heat shock protein 27, are intensively investigated as optimal targets for AS ODN therapy. In this review, we attempted to summarize the progress in the novel therapeutic strategy using AS ODN against CRPC, and to discuss the data of the recently completed and currently conducting clinical trials using AS ODNs as well as the future prospects of this therapy for treating CRPC.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyake
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D002986:Clinical Trials as Topic; D015316:Genetic Therapy; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics / Q000628:therapy*
chemical_list: D016376:Oligonucleotides, Antisense