title: Interference of fisetin with targets of the nuclear factor-κB signal transduction pathway activated by Epstein-Barr virus encoded latent membrane protein 1.
abstract: Fisetin is an effective compound extracted from lacquer which has been used in the treatment of various diseases. Preliminary data indicate that it also exerts specific anti-cancer effects. However, the manner in which fisetin regulates cancer growth remains unknown. In this study, we elucidated interference of fisetin with targets of the nuclear factorκB signal transduction pathway activated by Epstein-Barr virus encoding latent membrane protein 1 (LMP1)in nasopharyngeal carcinoma (NPC) cells, Results showed that fisetin inhibited the survival rate of CNE-LMP1 cells and NF-κB activation caused by LMP1. Fisetin also suppressed nuclear translocation of NF-κB (p65) and IκBα phosphorylation, while inhibiting CyclinD1, all key targets of the NF-κB signal transduction pathway. It was suggested that interference effects of fisetin with signal transduction activated by LMP1 encoded by the Epstein-Barr virus may play an important role in its anticancer potential.
authors.affiliation: Department of Pathology and Pathophysiology, School of Basic Medicine Science, Zhanjiang, China E-mail : luciazxj@163. com.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Liang
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Li
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Lin
authors.forename: Meng-Jie
authors.initials: MJ
authors.lastname: Shi
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002277:Carcinoma; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D010766:Phosphorylation / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014763:Viral Matrix Proteins / Q000378:metabolism*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D005419:Flavonoids; D044948:Flavonols; D016328:NF-kappa B; D014763:Viral Matrix Proteins; C017875:fisetin