title: Perfusion angiography of the foot in patients with critical limb ischemia: description of the technique.
abstract: OBJECTIVE
  To study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI).
  
  
  RESULTS
  Perfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds.
  
  
  CONCLUSIONS
  The original angiography data can be used to make a time-density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients.
authors.affiliation: Department of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands, s.jens@amc.uva.nl.
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Jens
authors.forename: Henk A
authors.initials: HA
authors.lastname: Marquering
authors.forename: Mark J W
authors.initials: MJ
authors.lastname: Koelemay
authors.forename: Jim A
authors.initials: JA
authors.lastname: Reekers
mesh_terms: D000792:Angiography; D001783:Blood Flow Velocity; D003287:Contrast Media; D005240:Feasibility Studies; D005528:Foot / Q000098:blood supply* / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement; D007511:Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology; D055420:Perfusion Imaging / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000209:etiology*; D011150:Popliteal Artery / Q000000981:diagnostic imaging; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol