title: Prevalence analysis of de novo hepatic steatosis following pylorus-preserving pancreaticoduodenectomy.
abstract: BACKGROUND
  Prevalence of hepatic steatosis following pylorus-preserving pancreaticoduodenectomy (PPPD) is high. This study intended to reveal the prevalence and patterns of de novo hepatic steatosis following PPPD.
  
  
  METHODS
  We investigated postoperative de novo hepatic steatosis following PPPD (n = 101) with a control group of bile duct resection (BDR) (n = 54).
  
  
  RESULTS
  At postoperative 1 year, hepatic steatosis occurred in 21 of 82 patients (25.6%) of PPPD group and in 2 of 47 patients (4.3%) of BDR group (p = 0.001). Thereafter, at 2 to 5 years, a high prevalence of hepatic steatosis persisted in the PPPD group, but no further occurrence developed in BDR group. Once steatosis developed, it persisted until the end of the study period or patient death. Five-year cumulative incidence of hepatic steatosis was 26.7% in the PPPD group and 3.7% in BDR group (p < 0.001). Univariate analyses showed that patient sex, age, body mass index, blood lipid profile, recurrence of tumor, and diabetes did not have significant influence on the development of hepatic steatosis following PPPD.
  
  
  CONCLUSIONS
  De novo hepatic steatosis may develop in a not negligible proportion of patients undergone PPPD. Multicenter studies with a high number of patients are needed to elucidate its pathogenesis and to find effective treatment for pancreaticoduodenectomy-associated hepatic steatosis.
authors.affiliation: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Dae-Gwang
authors.initials: DG
authors.lastname: Yoo
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Jung
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: Song-Chul
authors.initials: SC
authors.lastname: Kim
authors.forename: Ki-Hun
authors.initials: KH
authors.lastname: Kim
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Ahn
authors.forename: Deok-Bog
authors.initials: DB
authors.lastname: Moon
authors.forename: Kang-Mo
authors.initials: KM
authors.lastname: Kim
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Ha
authors.forename: Sung-Hwa
authors.initials: SH
authors.lastname: Kang
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
mesh_terms: D000704:Analysis of Variance; D001652:Bile Ducts / Q000601:surgery; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D059351:Organ Sparing Treatments / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D011708:Pylorus; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome