title: Treg cells and CTLA-4: the ball and chain of the germinal center response.
abstract: The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center.
authors.affiliation: Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: michelle.linterman@babraham.ac.uk.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Linterman
authors.affiliation: CRUK Cambridge Institute and Department of Medicine, University of Cambridge, Cambridge CB2 0RE, UK.
authors.forename: Alice E
authors.initials: AE
authors.lastname: Denton
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D060908:CTLA-4 Antigen / Q000276:immunology* / Q000378:metabolism*; D049109:Cell Proliferation; D018858:Germinal Center / Q000276:immunology*; D056724:Immunity, Humoral; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D060908:CTLA-4 Antigen