title: Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles.
abstract: In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).
authors.affiliation: State Key Laboratory of Luminescence and Application, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033, P. R. China. xgkong14@ciomp.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Jasmin A
authors.initials: JA
authors.lastname: Holz
authors.forename: Yadan
authors.initials: Y
authors.lastname: Ding
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Liu
authors.forename: Youlin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Langping
authors.initials: L
authors.lastname: Tu
authors.forename: Xianggui
authors.initials: X
authors.lastname: Kong
authors.forename: Bram
authors.initials: B
authors.lastname: Priem
authors.forename: Annemarie
authors.initials: A
authors.lastname: Nadort
authors.forename: Saskia A G
authors.initials: SA
authors.lastname: Lambrechts
authors.forename: Maurice C G
authors.initials: MC
authors.lastname: Aalders
authors.forename: Wybren Jan
authors.initials: WJ
authors.lastname: Buma
authors.forename: Yichun
authors.initials: Y
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000187:drug effects / Q000502:physiology; D005459:Fluorides / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D018613:Microscopy, Confocal; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D009367:Neoplasm Staging; D009369:Neoplasms / Q000473:pathology; D015019:Yttrium / Q000737:chemistry
chemical_list: D000911:Antibodies, Monoclonal; C525362:sodium yttriumtetrafluoride; D015019:Yttrium; D005459:Fluorides