title: Architecture and biological applications of artificial neural networks: a tuberculosis perspective.
abstract: Advancement of science and technology has prompted researchers to develop new intelligent systems that can solve a variety of problems such as pattern recognition, prediction, and optimization. The ability of the human brain to learn in a fashion that tolerates noise and error has attracted many researchers and provided the starting point for the development of artificial neural networks: the intelligent systems. Intelligent systems can acclimatize to the environment or data and can maximize the chances of success or improve the efficiency of a search. Due to massive parallelism with large numbers of interconnected processers and their ability to learn from the data, neural networks can solve a variety of challenging computational problems. Neural networks have the ability to derive meaning from complicated and imprecise data; they are used in detecting patterns, and trends that are too complex for humans, or other computer systems. Solutions to the toughest problems will not be found through one narrow specialization; therefore we need to combine interdisciplinary approaches to discover the solutions to a variety of problems. Many researchers in different disciplines such as medicine, bioinformatics, molecular biology, and pharmacology have successfully applied artificial neural networks. This chapter helps the reader in understanding the basics of artificial neural networks, their applications, and methodology; it also outlines the network learning process and architecture. We present a brief outline of the application of neural networks to medical diagnosis, drug discovery, gene identification, and protein structure prediction. We conclude with a summary of the results from our study on tuberculosis data using neural networks, in diagnosing active tuberculosis, and predicting chronic vs. infiltrative forms of tuberculosis.
authors.affiliation: Department of Chemistry, University of Arkansas at Little Rock, 2801 S University Ave, Little Rock, AR, 72204, USA.
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Darsey
authors.forename: William O
authors.initials: WO
authors.lastname: Griffin
authors.forename: Sravanthi
authors.initials: S
authors.lastname: Joginipelli
authors.forename: Venkata Kiran
authors.initials: VK
authors.lastname: Melapu
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D055808:Drug Discovery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008954:Models, Biological; D009415:Nerve Net; D016571:Neural Networks, Computer; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D014376:Tuberculosis / Q000175:diagnosis*
chemical_list: D011506:Proteins