title: The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery.
abstract: The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.
authors.affiliation: School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk.
authors.forename: Mthulisi
authors.initials: M
authors.lastname: Khuphe
authors.forename: Algy
authors.initials: A
authors.lastname: Kazlauciunas
authors.forename: Martin
authors.initials: M
authors.lastname: Huscroft
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thornton
mesh_terms: D000409:Alanine / Q000737:chemistry; D002918:Chymotrypsin / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry*; D016503:Drug Delivery Systems; D006868:Hydrolysis; D008823:Micelles; D010196:Pancreatic Elastase / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry; D058105:Polymerization; D012521:Sarcosine / Q000737:chemistry; D013820:Thermolysin / Q000737:chemistry*
chemical_list: D008823:Micelles; D010455:Peptides; D010649:Phenylalanine; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D013820:Thermolysin; D000409:Alanine; D004298:Dopamine; D012521:Sarcosine