title: Primary hepatic amyloidosis presenting as nodular masses on the background of diffuse infiltration and extreme liver stiffness on MR elastography.
abstract: Amyloidosis is characterized by the deposition of extracellular protein material, amyloid, in various organs. The clinical and imaging features of the disease are often nonspecific and a tissue biopsy is often required. We present the case of a 64-year-old man with biopsy proven amyloidosis of the liver. The patient presented with non-specific clinical symptoms. Routine imaging showed hepatomegaly with heterogeneous enhancement, and several large nodular space occupying lesions, mimicking neoplasm. MR elastography revealed an extremely stiff liver. Amyloidosis presenting as multiple nodular masses on the background of diffuse infiltrative pattern or demonstration of extreme stiffness in hepatic amyloidosis on MR elastography have not been described previously.
authors.affiliation: Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore 768828 Republic of Singapore. sivasu2@gmail.com.
authors.forename: Sivasubramanian
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore 768828 Republic of Singapore.
authors.forename: Yi Qi
authors.initials: YQ
authors.lastname: Tan
authors.affiliation: Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore 768828 Republic of Singapore.
authors.forename: Hui Seong
authors.initials: HS
authors.lastname: Teh
authors.affiliation: Department of Gastroenterology,Khoo Teck Puat Hospital, Singapore 768828 Republic of Singapore.
authors.forename: Piao Jarrod
authors.initials: PJ
authors.lastname: Lee
authors.affiliation: Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore 768828 Republic of Singapore.
authors.forename: Ree Nee
authors.initials: RN
authors.lastname: Khoo
mesh_terms: D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed