title: Symptoms of depression impact the course of lung function in adolescents and adults with cystic fibrosis.
abstract: BACKGROUND
  Epidemiological studies report high rates of depression among patients with cystic fibrosis (CF). Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years.
  
  
  METHODS
  In the context of the TIDES study, 473 German patients with CF (age 12-53 years, FEV1% predicted M = 66.2, range 13-137) completed the Hospital Anxiety and Depression Scale (HADS). Lung function (FEV1% predicted) was assessed at baseline and followed up two years later. Repeated measures analysis was performed involving the level of FEV1% and the level of depressive symptoms at baseline as independent factors and FEV1% at the 2-year follow-up as the dependent variable.
  
  
  RESULTS
  Interaction between lung function and depression at baseline significantly affected the change in lung function at the 2-years observation interval. The largest decline in FEV1% occurred in depressed patients with good lung function at baseline. In contrast, patients without any clinically relevant depressive symptoms and with poor lung function at baseline showed a slight increase two years later.
  
  
  CONCLUSIONS
  The findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression.
authors.affiliation: Department of Child and Adolescent Psychiatry/ Psychotherapy, University Ulm Medical Centre, Steinhoevelstr, 1, 89075 Ulm, Germany. astrid.fidika@uniklinik-ulm.de.
authors.forename: Astrid
authors.initials: A
authors.lastname: Fidika
authors.forename: Marion
authors.initials: M
authors.lastname: Herle
authors.forename: Lutz
authors.initials: L
authors.lastname: Goldbeck
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology* / Q000523:psychology*; D003863:Depression / Q000503:physiopathology* / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D055815:Young Adult