title: Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.
abstract: OBJECTIVE
  Given reports of high pain thresholds and reduced auditory response in individuals with agenesis of the corpus callosum (AgCC), this study investigated whether affected participants report atypical experiences and behaviors on a well-established sensory processing measure.
  
  
  METHODS
  Fourteen participants with AgCC (ages 11-59) completed the Adolescent/Adult Sensory Profile (Brown & Dunn, 2001). Sensory profile scales were classified as "Atypical" if they were more than 1 standard deviation from the mean.
  
  
  RESULTS
  Fifty-seven percent of participants with AgCC reported reduced sensory registration as compared to an expected 16% of the normative sample. Similarly, 50% of the AgCC participants reported atypically increased auditory processing difficulties.
  
  
  CONCLUSIONS
  Using a well-established sensory processing questionnaire, participants with AgCC reported measurable differences in multiple aspects of sensory processing. The most notable difference was in the quadrant of low sensory registration, suggesting that individuals with AgCC may require sensory information to be presented more slowly or at a higher intensity for adequate processing. The sensory modality that was most affected was the auditory system, which is consistent with increased rates of language disorders and autism spectrum disorders in this population. Understanding sensory processing in individuals with AgCC can both elucidate the role of interhemispheric transfer in the development of intact sensory processing as well as contribute to our knowledge of the role of the corpus callosum in a range of disorders in which sensory processes are impacted. (PsycINFO Database Record
authors.affiliation: University of California-San Francisco, Department of Radiology & Biomedical Imaging, 513 Parnassus Avenue, S362, San Francisco, CA 94143-0628.
authors.forename: Carly
authors.initials: C
authors.lastname: Demopoulos
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026.
authors.forename: Monica S
authors.initials: MS
authors.lastname: Arroyo
authors.affiliation: University of Kansas Medical Center, Department of Occupational Therapy Education, 3901 Rainbow Blvd / MS2003, Kansas City, KS 66160.
authors.forename: Winnie
authors.initials: W
authors.lastname: Dunn
authors.affiliation: University of California-San Francisco, Department of Neurology, 675 Nelson Rising Lane, San Francisco, CA 94143.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Strominger
authors.affiliation: University of California-San Francisco, Department of Neurology, 675 Nelson Rising Lane, San Francisco, CA 94143.|University of California-San Francisco, Department of Pediatrics, 400 Parnassus Avenue, San Francisco, CA 94143.
authors.forename: Elliott H
authors.initials: EH
authors.lastname: Sherr
authors.affiliation: University of California-San Francisco, Department of Neurology, 675 Nelson Rising Lane, San Francisco, CA 94143.|University of California-San Francisco, Department of Pediatrics, 400 Parnassus Avenue, San Francisco, CA 94143.|University of California-San Francisco, Department of Psychiatry, 401 Parnassus Avenue, San Francisco, CA 94143.
authors.forename: Elysa
authors.initials: E
authors.lastname: Marco
mesh_terms: D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D001307:Auditory Perception; D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D002648:Child; D003071:Cognition; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010465:Perception; D012677:Sensation; D011795:Surveys and Questionnaires; D055815:Young Adult