title: Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging.
abstract: Cognition in all mammals including human beings declines during aging. The cellular events responsible for this decay involve a reduction of neurogenesis in the dentate gyrus. Here, we show that treatment with a nature product from a traditional Chinese medicine, namely salidroside restores the capacity of the dentate gyrus to generate new neurons and intercepts learning and memory decays in mice during aging. We uncover that new neurons in aging mice have functional features of an adult granule neuron by forming excitatory synapses with their putative targeting neurons. Genetic inhibition of synaptic transmission from new neurons abolishes the therapeutic effects of salidroside in behavioral tests. We also identify that salidroside targets CREB transcription for the survival of new neurons in the dentate gyrus of old mice. Thus, salidroside is therapeutically effective against learning and memory decays via stimulation of CREB-dependent functional neurogenesis in aging.
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Pei
authors.affiliation: Translational Medical Research Center, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Shu
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Physiology, China Pharmaceutical University, No. 24, Tong Jia Xiang Street, 210009, Nanjing, China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yan
authors.affiliation: Translational Medical Research Center, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wei
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Chengye
authors.initials: C
authors.lastname: Yao
authors.affiliation: Department of Genetics, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Translational Medical Research Center, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China. Katelinwang@126.com.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China. Katelinwang@126.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. lym@hust.edu.cn.|Institute of Brain Research, Huazhong University of Science and Technology, 430030, Wuhan, China. lym@hust.edu.cn.
authors.forename: Youming
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D018891:Dentate Gyrus / Q000187:drug effects / Q000254:growth & development; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D007858:Learning / Q000187:drug effects*; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D065852:Spatial Memory / Q000187:drug effects; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D005960:Glucosides; D010636:Phenols; D049452:Green Fluorescent Proteins; C009172:rhodioloside
keywords: Aging; CREB; Learning and memory decays; Neurogenesis; Salidroside