title: Asymmetric dual-reagent catalysis: Mannich-type reactions catalyzed by ion pair.
abstract: The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied to Mannich-type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China).
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Chang-Wu
authors.initials: CW
authors.lastname: Zheng
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chai
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Cao
authors.forename: Jia-Xing
authors.initials: JX
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
keywords: asymmetric synthesis; fluorine; imines; organocatalysis; phosphines