title: Understanding the cytotoxicity or cytoprotective effects of biological and synthetic quinone derivatives by redox mechanism.
abstract: Quinones represent an important class of biological compounds, but are also involved with toxicological intermediates and among their hazardous effects include cytotoxicity, immunotoxicity, and carcinogenesis. The structure-toxicity relationship for quinone derivatives has been used to cytotoxicity or cytoprotective effects by redox mechanism is determined using quantum chemical calculations through the density functional theory (DFT). According to our DFT study, the electron acceptance is related with LUMO, electron affinity, and stabilization energy values. The highest spin density distribution in the heteroatoms is more favored for the more cytotoxic compounds. The electrophilic capacities of these compounds have been related with LUMO values. The cytotoxic properties of quinones are related to the stabilization energy after electron accepting by redox mechanism. Electron affinity is the most relevant parameter related to toxicity mechanism. Regioisomers has different electrophilic capacity. The electrophilicity increases on molecules containing electron-withdrawing groups (EWG) and reduces on molecules containing electron-donating groups (EDG). These results explain the toxic difference between natural and synthetic quinone derivatives and can be used in the design and study of new drugs.
authors.affiliation: Núcleo de Estudos e Seleção de Moléculas Bioativas, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil, rosborg@ufpa.br.
authors.forename: Rosivaldo S
authors.initials: RS
authors.lastname: Borges
authors.forename: Agnaldo S
authors.initials: AS
authors.lastname: Carneiro
authors.forename: Tainá G
authors.initials: TG
authors.lastname: Barros
authors.forename: Carlos A L
authors.initials: CA
authors.lastname: Barros
authors.forename: Antonio M J Chaves
authors.initials: AM
authors.lastname: Neto
authors.forename: Albérico B F
authors.initials: AB
authors.lastname: da Silva
mesh_terms: D019610:Cytoprotection; D004355:Drug Stability; D004583:Electrons; D004735:Energy Transfer; D005609:Free Radicals / Q000737:chemistry; D007536:Isomerism; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011789:Quantum Theory; D011809:Quinones / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D005609:Free Radicals; D011809:Quinones