title: Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia.
abstract: Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
authors.forename: Selva Perumal
authors.initials: SP
authors.lastname: Gunaletchumy
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
authors.forename: Indran
authors.initials: I
authors.lastname: Seevasant
authors.affiliation: Malaysian Genomics Resource Centre Berhad, 59200 Kuala Lumpur Malaysia.
authors.forename: Mun Hua
authors.initials: MH
authors.lastname: Tan
authors.affiliation: Malaysian Genomics Resource Centre Berhad, 59200 Kuala Lumpur Malaysia.
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Croft
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052 Australia.
authors.forename: Hazel M
authors.initials: HM
authors.lastname: Mitchell
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
authors.forename: Khean Lee
authors.initials: KL
authors.lastname: Goh
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
authors.forename: Mun Fai
authors.initials: MF
authors.lastname: Loke
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
authors.forename: Jamuna
authors.initials: J
authors.lastname: Vadivelu
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics; D005756:Gastritis / Q000382:microbiology*; D005798:Genes, Bacterial; D056726:Genetic Association Studies; D014644:Genetic Variation; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D008296:Malaysia; D008969:Molecular Sequence Data; D058885:Multilocus Sequence Typing; D010437:Peptic Ulcer / Q000382:microbiology*; D010802:Phylogeny; D013274:Stomach Neoplasms / Q000382:microbiology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D005634:Fructose-Bisphosphate Aldolase