title: Remarkable response to neoadjuvant therapy with methotrexate, vinblastine, adriamycin, and Cisplatin for undifferentiated bladder carcinoma: a case report and literature review.
abstract: We report a case of primary undifferentiated bladder carcinoma, which revealed a remarkable response to methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) therapy. A 46-year-old Japanese woman presented at the hospital with the chief complaints of gross hematuria and pain during urination. Cystoscopy revealed a large smooth-surfaced tumor in the urinary bladder. The histopathological diagnosis was undifferentiated carcinoma. The patient then received 3 courses of MVAC over a 3-month period. Hydronephrosis disappeared after the first course, and the tumor shrank rapidly. After completion of the third MVAC course, radical cystectomy and ileal conduit surgery were performed. After 7 years, the patient has still had no recurrences or metastases. We retrospectively review the relative efficacy of the two popular chemotherapeutic regimens in the management of muscle-invasive bladder cancer in patients who had had radical cystectomy.
authors.affiliation: Department of Urology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Numahata
authors.affiliation: Department of Urology, Yamagata Prefectural Central Hospital, Yamagata, Japan ; Department of Urology, Yamagata Tokushukai Hospital, Yamagata, Japan.
authors.forename: Senji
authors.initials: S
authors.lastname: Hoshi
authors.affiliation: Department of Urology, Yamagata Tokushukai Hospital, Yamagata, Japan.
authors.forename: Kiyotsugu
authors.initials: K
authors.lastname: Hoshi
authors.affiliation: Kan-etsu Hospital, Saitama, Josai University, Sakado, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yasuno
authors.affiliation: Clinical Pathophysiology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kubo
authors.affiliation: Department of Urology, Yamagata Tokushukai Hospital, Yamagata, Japan.
authors.forename: Isoji
authors.initials: I
authors.lastname: Sasagawa
authors.affiliation: Kan-etsu Hospital, Saitama, Josai University, Sakado, Japan ; Clinical Pathophysiology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohta
keywords: Methotrexate, vinblastine, adriamycin, and cisplatin; Neoadjuvant chemotherapy; Undifferentiated bladder carcinoma