title: Alteration of behavioral changes and hippocampus galanin expression in chronic unpredictable mild stress-induced depression rats and effect of electroacupuncture treatment.
abstract: To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models. Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Eighteen male Sprague-Dawley rats were randomly assigned into three groups: control, model, and EA groups. Rats were treated by EA once daily for 21 days. The results showed that body weight and sucrose consumption were significantly increased in EA group than in the model group. The crossing numbers and rearing numbers in the open field test significantly decreased in the model group but not in the EA group. And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels. The present study suggested that EA had antidepressant effects on UCMS model rats. The potential antidepressant effect may be related to upregulating Gal expression in hippocampus.
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Mo
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Traditional Chinese Medicine, Inner Mongolia People's Hospital, No. 20 Zhao Wuda Road, Hohhot, Inner Mongolia Autonomous Region 010017, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Wanshun
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Jiawula
authors.initials: J
authors.lastname: Abulizi
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Anping
authors.initials: A
authors.lastname: Xu
authors.affiliation: Department of Traditional Chinese Medicine and Rehabilitation, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, Zhejiang 310009, China.
authors.forename: Yinshan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Xiangbo
authors.initials: X
authors.lastname: Han
authors.affiliation: School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li