title: Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum.
abstract: Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM.
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. zhuravleva.oi@dvfu.ru.
authors.forename: Olesya I
authors.initials: OI
authors.lastname: Zhuravleva
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. sobolevskaya_m@mail.ru.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Sobolevskaya
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. afiyat@piboc.dvo.ru.
authors.forename: Shamil Sh
authors.initials: SSh
authors.lastname: Afiyatullov
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. slinkina@piboc.dvo.ru.
authors.forename: Natalya N
authors.initials: NN
authors.lastname: Kirichuk
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. vladenis@piboc.dvo.ru.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. paveldmt@piboc.dvo.ru.
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. dminae@mail.ru.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Yurchenko
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia. dyshlovoy@gmail.com.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
mesh_terms: D000818:Animals; D005658:Fungi / Q000737:chemistry*; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D010407:Penicillium / Q000737:chemistry*; D000459:Phaeophyceae / Q000382:microbiology*; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D018808:Transcription Factor AP-1 / Q000378:metabolism
chemical_list: D005663:Furans; D013141:Spiro Compounds; D018808:Transcription Factor AP-1; C520774:spiroketal