title: Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.
abstract: Isocyanoterpenes (ICTs) are marine natural products biosynthesized through an unusual pathway that adorns terpene scaffolds with nitrogenous functionality derived from cyanide. The appendage of nitrogen functional groups - isonitriles in particular - onto stereochemically-rich carbocyclic ring systems provides enigmatic, bioactive molecules that have required innovative chemical syntheses. This review discusses the challenges inherent to the synthesis of this diverse family and details the development of the field. We also present recent progress in isolation and discuss key aspects of the remarkable biological activity of these compounds.
authors.affiliation: Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21701, USA. martin.schnermann@nih.gov.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schnermann
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Shenvi
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001688:Biological Products; D003486:Cyanides; D013729:Terpenes