title: Current status on histological classification in Cushing's disease.
abstract: BACKGROUND
  Managing Cushing's disease remains a challenge. Surgery is the first option of treatment and it offers a high success rate. Even in cases where biochemical remission is not achieved, it is crucial to obtain surgical tissue for morphological diagnosis because the therapeutic approach can be modified according to the findings.
  
  
  METHODS
  A literature search was performed using PubMed for information regarding pathology and Cushing's disease.
  
  
  RESULTS
  The histopathological features found in the pituitary gland of patients with Cushing's disease are presented.
  
  
  CONCLUSIONS
  Different subtypes of ACTH-producing pituitary tumors are recognized and characterized. The significance of finding a normal pituitary gland with or without Crooke's changes is also discussed.
authors.affiliation: Department of Neurosurgery, Hospital Pablo Tobon Uribe, Clinica Medellin and Group of Genetics, Regeneration and Cancer, Universidad de Antioquia, Medellín, Colombia, lvsyro@une.net.co.
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.forename: Eva
authors.initials: E
authors.lastname: Horvath
authors.forename: Lina M
authors.initials: LM
authors.lastname: Restrepo
authors.forename: Min
authors.initials: M
authors.lastname: Wong
authors.forename: Donald W
authors.initials: DW
authors.lastname: Killinger
authors.forename: Harley
authors.initials: H
authors.lastname: Smyth
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D001706:Biopsy; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000145:classification / Q000473:pathology* / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012074:Remission Induction; D016896:Treatment Outcome