title: High-resolution localized spatiotemporal encoding correlated spectra under inhomogeneous magnetic fields via asymmetrical gradient encoding/decoding.
abstract: Applications of conventional localized nuclear magnetic resonance correlated spectroscopy are restrained by long acquisition times and poor performance under inhomogeneous magnetic fields. Here, a method that combines the spatiotemporal encoding technique with the localization technique and implements the encoding and decoding in unison with suitable asymmetrical gradients is proposed to obtain high-resolution localized correlated spectra under inhomogeneous fields in greatly reduced times. Experiments on phantom solutions prove its insensitivity to linear field inhomogeneities along three orthogonal axes. Moreover, this method is applied to adipose study of marrow tissue with resolution improvements. The proposed method may offer promising perspectives for fast analyses of biological tissues.
authors.affiliation: Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory for the Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Wei
authors.forename: Liangjie
authors.initials: L
authors.lastname: Lin
authors.forename: Chuchu
authors.initials: C
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Guangcao
authors.initials: G
authors.lastname: Liu
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhong
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D000818:Animals; D001853:Bone Marrow / Q000033:anatomy & histology; D060526:Magnetic Fields; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging; D011422:Propionates / Q000378:metabolism; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D011422:Propionates; C035776:3-bromopropionic acid
keywords: 3D linear inhomogeneity; adipose tissue; asymmetrical gradient; correlated spectroscopy; high resolution; localization; spatiotemporal encoding; ultrafast