title: [Gonadal toxicity of cancer therapies in children].
abstract: Numerous cytotoxic drugs used to treat childhood cancers, as well as pelvic or hypothalamo- pituitary irradiation and gonadal surgery, can affect subsequent hormonal function and fertility. Prevention of these adverse consequences is based primarily on therapeutic de-escalation when possible, and now also on gonad or gamete preservation. These patients and their parents must receive thorough information, taking into account the child's age, the proposed treatments, and the length of follow-up. Teams treating childhood cancers must receive appropriate training, and access to innovative fertility-preserving techniques must be guaranteed at the national level.
authors.forename: François
authors.initials: F
authors.lastname: Doz
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects; D004700:Endocrine System Diseases / Q000139:chemically induced; D004704:Endocrinology; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology / Q000528:radiation effects; D007247:Infertility, Female / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D007248:Infertility, Male / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D033183:Interdisciplinary Communication; D008297:Male; D008495:Medical Oncology; D009369:Neoplasms / Q000628:therapy*; D009919:Orchiectomy / Q000009:adverse effects; D059351:Organ Sparing Treatments; D010052:Ovariectomy / Q000009:adverse effects; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects; D018456:Reproductive Medicine; D013737:Testis / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents