title: SUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.
abstract: The design of SUPPORT has been widely misunderstood. This confusion has driven much of the debate about the trial - and threatens the whole enterpise of comparative effectiveness research.
authors.forename: John D
authors.initials: JD
authors.lastname: Lantos
authors.forename: Chris
authors.initials: C
authors.lastname: Feudtner
mesh_terms: D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D057186:Comparative Effectiveness Research / Q000941:ethics* / Q000379:methods / Q000592:standards / Q000639:trends; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D015931:Intensive Care, Neonatal / Q000941:ethics* / Q000379:methods / Q000592:standards; D007442:Intubation, Intratracheal; D009026:Mortality; D009359:Neonatology / Q000941:ethics / Q000379:methods / Q000592:standards; D010092:Oximetry / Q000941:ethics / Q000295:instrumentation / Q000379:methods; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D033282:Parental Consent / Q000941:ethics*; D011175:Positive-Pressure Respiration / Q000941:ethics; D016032:Randomized Controlled Trials as Topic / Q000941:ethics; D012107:Research Design / Q000592:standards; D012178:Retinopathy of Prematurity / Q000209:etiology / Q000517:prevention & control*; D059039:Standard of Care / Q000941:ethics; D013501:Surface-Active Agents / Q000008:administration & dosage; D016896:Treatment Outcome; D014342:Truth Disclosure / Q000941:ethics*; D035501:Uncertainty
chemical_list: D013501:Surface-Active Agents; D010100:Oxygen