title: A Swiss Army knife for CTLs.
abstract: Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash et al. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell diapedesis into inflamed tissue.
authors.affiliation: Department of Cell Biology (283), Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands; David H. Koch Center for Applied Research of Genitourinary Cancers, Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Cancer Genomics Centre Netherlands (CGC.nl), Department of Molecular Cancer Research, University Medical Center Utrecht, HP Stratenum 3.217, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: peter.friedl@radboudumc.nl.
authors.forename: Peter
authors.initials: P
authors.lastname: Friedl
authors.affiliation: Department of Cell Biology (283), Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
authors.forename: Bettina
authors.initials: B
authors.lastname: Weigelin
mesh_terms: D000818:Animals; D004481:Ectromelia virus / Q000276:immunology*; D004482:Ectromelia, Infectious / Q000276:immunology*; D053804:Granzymes / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology*
chemical_list: D053804:Granzymes