title: Synthesis and Crystallographic Study ofN'-(1-benzylpiperidin-4-yl)acetohydrazide.
abstract: As part of a study into new Fentanyl-derived opioid compounds with potent analgesic activity and reduced side effects the starting material title compound, C14H21N3O (1), was synthesized and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The crystal structure is monoclinicCcwith unit cell parametersa= 14.1480(3) Å,b= 14.1720(4) Å,c= 27.6701(7) Å,β= 96.956(1)°,α=γ= 90°. The compound has crystallized with four crystallographically unique molecules in the asymmetric unit; each molecule has a very similar conformation and an analysis of the structure shows that although all four unique molecules overlay very well there is no evidence ofpseudo-symmetry which would relate the molecules in the higher symmetry space groupC2/c. The crystal packing consists of two separate hydrogen bonded chains which are linked together to form a thick 2D structure in theabplane.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Nichol
authors.affiliation: Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Ruben
authors.initials: R
authors.lastname: Vardanyan
authors.affiliation: Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
keywords: Hydrogen bonding; Organic compounds; Z′ > 1