title: [Mesectodermal leiomyoma. Unusual tumor of the ciliary body].
abstract: BACKGROUND
  Mesectodermal leiomyoma is a benign tumor of smooth muscle of the ciliary body, which is derived from the neural crest.
  
  
  METHODS
  We report the case of a 35-year-old Mexican woman with visually impaired and blurred vision of the right eye of 2 months duration. The clinical and imaging presuntional diagnosis was adenoma of the non pigmented epithelium of the ciliary body and it was surgically resected. Microscopically, the tumor was composed of cells with round nuclei and scant cytoplasm without atypia or mitosis, arranged in a fibrillary background. The immunohistochemical markers for vimentin, muscle specific actin, smooth muscle actin and calponin were strongly positive in the cytoplasm of the neoplastic cells, while for glial fibrillary acidic protein and S-100 protein were negative in the same cellular population.
  
  
  CONCLUSIONS
  Mesectodermal leiomyoma of the ciliary body is benign tumor of smooth muscle extremely rare in this location. Until now, there are just 25 previous reported cases in the literature and, the main differential diagnosis is uveal malignant melanoma, therefore some eyes were enucleated. The ultrabiomicroscopy, A and B-scan imaging studies are useful in the evaluation, however, is mandatory the microsocpic examination with routine and histochemical stains as well as the use of immunohistochemical markers such as vimentin, specific muscle actin, smooth muscle actin andcalponin to stablish the smooth muscle origin of this neoplasm, and rule out other malignant neoplams such as malignant melanoma.
authors.affiliation: Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.
authors.forename: Nancy Paulina
authors.initials: NP
authors.lastname: Rentería-Ruiz
authors.affiliation: Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.
authors.forename: Guillermo
authors.initials: G
authors.lastname: de Wit-Carter
authors.affiliation: Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Villaseñor-Diez
authors.affiliation: División de Investigación, Hospital Juárez de México, Mexico.
authors.forename: José Javier
authors.initials: JJ
authors.lastname: Flores-Estrada
authors.affiliation: Servicio de Patología Oftálmica, Asociación para Evitar la Ceguera en México IAP. Hospital Dr. Luis Sánchez Bulnes, Mexico DF, Mexico. arodri2@yahoo.com.
authors.forename: Abelardo Antonio
authors.initials: AA
authors.lastname: Rodríguez-Reyes
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002924:Ciliary Body / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005136:Eye Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008545:Melanoma / Q000175:diagnosis; D033401:Microscopy, Acoustic; D014604:Uveal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D005136:Eye Proteins
keywords: Mesectodermal leiomyoma; ciliary body; cuerpo ciliar; immunohistochemistry; inmunohistoquímica; leiomioma mesectodérmico