title: A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents.
abstract: Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.
authors.affiliation: Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, 08017, Barcelona, Spain. santi.nonell@iqs.url.edu.
authors.forename: Oriol
authors.initials: O
authors.lastname: Planas
authors.forename: Thibault
authors.initials: T
authors.lastname: Gallavardin
authors.forename: Santi
authors.initials: S
authors.lastname: Nonell
mesh_terms: D000588:Amines / Q000737:chemistry; D057930:Click Chemistry; D005453:Fluorescence; D007259:Infrared Rays; D017879:Isothiocyanates / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D011789:Quantum Theory; D026082:Singlet Oxygen / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D000068936:Theranostic Nanomedicine; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000588:Amines; D017879:Isothiocyanates; D011166:Porphyrins; D011506:Proteins; D013844:Thiazoles; D026082:Singlet Oxygen