title: Inhibiting EGFR clustering and cell proliferation with gold nanoparticles.
abstract: Gold nanoparticles are functionalized with epidermal growth factor (EGF) molecules and incubated with HeLa cells. These new complexes mechanically interfere with the activation of EGF receptors in a length-dependent manner. Protein-functionalized gold nanoparticles hold great potential for unveiling the fundamental characteristics of cell receptors and for future pharmacological studies on receptor targeting.
authors.affiliation: Centre for Micro-Photonics, Faculty of Engineering, Science and Technology, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria, 3122, Australia.
authors.forename: Chiara
authors.initials: C
authors.lastname: Paviolo
authors.forename: James W M
authors.initials: JW
authors.lastname: Chon
authors.forename: Andrew H A
authors.initials: AH
authors.lastname: Clayton
mesh_terms: D049109:Cell Proliferation; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles
chemical_list: D006046:Gold; D066246:ErbB Receptors
keywords: epidermal growth factor; epidermal growth factor receptor; gold nanoparticles