title: PINK1-PARKIN interplay: down to ubiquitin phosphorylation.
abstract: By using quantitative proteomics, Ordureau et al. (2014) provide a comprehensive view on the regulatory steps by which PINK1-mediated phosphorylation of PARKIN and ubiquitin triggers the recruitment of the ubiquitin ligase PARKIN to damaged mitochondria.
authors.affiliation: Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Stolz
authors.affiliation: Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Strasse 15, 60438 Frankfurt am Main, Germany. Electronic address: ivan.dikic@biochem2.de.
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D025821:Polyubiquitin / Q000096:biosynthesis*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D025821:Polyubiquitin; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein