title: [Early gastric cancer and precancerous conditions diagnostics with confocal laser endomicroscopy].
abstract: OBJECTIVE
  To develop endomicroscopic criteria of early gastric cancer and precancerous conditions
  
  
  METHODS
  157 suspected for early gastric cancer patients were included in our study. In all cases complex endoscopic examination (narrow-band imaging NBI-HD endoscopy, endosonography (EUS) and endoscope-based confocal laser endomicroscopy (CLE) with precise biopsy) was performed. CLE images compared to pathology data.
  
  
  RESULTS
  Precise criteria of intestinal metaplasia in CLE was presence of oval gray goblet cells in epithelium. Gastric adenoma with moderate dysplasia appeared on CLE images as glandular structures in mucosa surface layers. The signs of high-grade dysplastic changes in adenoma were appearing of different shape and size cells with lost polarity. Well-differentiated carcinoma featured destruction of some glands and forming dark cell clusters. Revealed criteria of poor-differentiated carcinoma was total disintegration of glandular structures. Overall accuracy of CLE in early gastric cancer and precancerous conditions diagnostics reached 95,6% (P < 0.001). Selected accuracy in different condition was: 100% in intestinal metaplasia identifying, 86.1%--in adenoma with moderate dysplasia, 96.2% in high-grade dysplasia and cancer in situ, and 100%--in poor-differentiated gastric carcinoma types).
  
  
  CONCLUSIONS
  As the result of our study we have developed precise endomicroscopic criteria of intestinal metaplasia in stomach, gastric adenoma with moderate and high-grade dysplasia and early gastric cancer--as well-differentiated, as poor-differentiated.
authors.forename: S S
authors.initials: SS
authors.lastname: Pirogov
authors.forename: V V
authors.initials: VV
authors.lastname: Sokolov
authors.forename: E S
authors.initials: ES
authors.lastname: Karpova
authors.forename: P V
authors.initials: PV
authors.lastname: Pavlov
authors.forename: N N
authors.initials: NN
authors.lastname: Volchenko
authors.forename: A D
authors.initials: AD
authors.lastname: Kaprin
mesh_terms: D000236:Adenoma / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005773:Gastroscopy / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000295:instrumentation / Q000379:methods; D011230:Precancerous Conditions / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*