title: [Gestational trophoblastic disease].
abstract: Gestational trophoblastic disease encompresses a group of interrelated diseases, following a pregnancy after a variable period of time. Hydatiform mole corresponds to premalignant disorders composed of villi with excess of paternal genetic material, with a malignant potential more important for complete mole than partial mole. Gestational trophoblastic neoplasia includes invasive mole, choriocarcinoma, placental site trophoblatic tumor and epithelioid trophoblastic tumor. Their histological diagnosis may be problematic on curettage material and needs to be correlated to serum hCG level and radiological findings. The use of chemotherapy has dramatically improved the prognosis of these lesions. All patients with this rare disease need to be registered in the national service for gestational trophoblastic disease (http://www.mole-chorio.com), which coordinates their management at the national level.
authors.affiliation: Service de pathologie Nord, hôpital de la Croix Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Centre des maladies trophoblastiques gestationnelles, centre hospitalier Lyon Sud, bâtiment 3B, 2(e) étage, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France. Electronic address: fabienne.allias@chu-lyon.fr.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Allias
authors.affiliation: Centre des maladies trophoblastiques gestationnelles, centre hospitalier Lyon Sud, bâtiment 3B, 2(e) étage, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France. Electronic address: touria.hajri@chu-lyon.fr.
authors.forename: Pierre-Adrien
authors.initials: PA
authors.lastname: Bolze
authors.affiliation: Service de pathologie Nord, hôpital de la Croix Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Gaillot-Durand
authors.affiliation: Service de pathologie Nord, hôpital de la Croix Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Centre des maladies trophoblastiques gestationnelles, centre hospitalier Lyon Sud, bâtiment 3B, 2(e) étage, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Devouassoux-Shisheboran
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006063:Chorionic Gonadotropin; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D016130:Immunophenotyping; D015994:Incidence; D019394:Ki-67 Antigen / Q000032:analysis; D009361:Neoplasm Invasiveness; D011247:Pregnancy; D011379:Prognosis; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D050759:Cyclin-Dependent Kinase Inhibitor p21; D019394:Ki-67 Antigen
keywords: Choriocarcinoma; Choriocarcinome; Gestational trophoblastic disease; Hydatiform mole; Maladies gestationnelles trophoblastiques; Môle hydatiforme