title: [Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension ].
abstract: OBJECTIVE
  To estimate the spread and distribution of genotypes and alleles of thrombosis predisposition gene polymorphisms in adolescents with essential hypertension (EH).
  
  
  METHODS
  One hundred and thirty-seven 14- to 17-year-old adolescents were examined. There were 3 examined groups: 1) 37 EH patients with prothrombotic changes (PTC); 2) 60 EH patients without PTC; 3) 40 healthy adolescents. Prothrombin time, activated partial thromboplastin time, and the levels of fibrinogen and soluble fibrin monomer complexes were determined. The adolescents were assigned to a PTC group if they had changes by one or several above indicators. Polymerase chain reaction assay was used to type coagulation factor II (FII) and factor V (FV), plasminogen activator inhibitor type 1 (PAI-7), 5,10-methylenetetrahydrofolate reductase (MTHFR), and methionine syntase reductase (MTRR) gene polymorphisms. Group differences were determined by qualitative signs, by using.the χ2test and Yates' correction for continuity and Fisher's exact test if one of the groups had at least 5 individuals. All differences were considered statistically significant at p < 0.05.
  
  
  RESULTS
  FV R506Q, FII G20210A, PAI1-675 4G/5G, MTHFR A1298C, and MTRR A66G polymorphisms have not been found to affect the hemostatic system in adolescents with EH. MTHFR C677T may act as a risk factor of PTC in adolescents with EH, by increasing the risk of thrombotic events at an old age.
  
  
  CONCLUSIONS
  It is recommended that the determination of molecular genetic markers for predisposition to thrombosis be actively used in adolescents with EA to form a risk group for thrombotic events and to implement preventive measures..
authors.forename: V V
authors.initials: VV
authors.lastname: Dolgikh
authors.forename: S E
authors.initials: SE
authors.lastname: Bol'shakova
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.forename: I M
authors.initials: IM
authors.lastname: Mikhalevich
mesh_terms: D000293:Adolescent; D001779:Blood Coagulation Factors / Q000235:genetics*; D001780:Blood Coagulation Tests; D000075222:Essential Hypertension; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D013927:Thrombosis / Q000209:etiology / Q000235:genetics
chemical_list: D001779:Blood Coagulation Factors; D005819:Genetic Markers; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)