title: Enantioselective construction of functionalized thiopyrano-indole annulated heterocycles via a formal thio [3 + 3]-cyclization.
abstract: A formal thio [3 + 3]-cyclization catalyzed by a DPEN-derived chiral thiourea has been reported for the construction of optically active thiopyrano-indole annulated heterocyclic compounds in high yields with excellent enantioselectivities. The high reactivity between indoline-2-thione (keto-S) and 2-benzylidenemalononitrile has also been supported by density functional theory (DFT) calculations.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Zheng-Hang
authors.initials: ZH
authors.lastname: Qi
authors.forename: Shao-Yun
authors.initials: SY
authors.lastname: Zhang
authors.forename: Ling-Pei
authors.initials: LP
authors.lastname: Kong
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xing-Wang
authors.initials: XW
authors.lastname: Wang
mesh_terms: D003500:Cyclization; D005029:Ethylenediamines / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D005029:Ethylenediamines; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D013890:Thiourea