title: Catalytic synthesis of sulfated polysaccharides I: Characterization of chemical structure.
abstract: In the present study, sulfated derivatives of Artemisia sphaerocephala polysaccharide (SASP) with high degree of substitution (DS) were synthesized by using 4-dimethylaminopyridine (DMAP)/dimethylcyclohexylcarbodiimide (DCC) as catalyst in homogeneous conditions. It was found that DMAP/DCC showed marked improvement in DS of sulfated samples. Compared to sulfated derivatives without catalyst, the DS of SASP increased from 0.91 to 1.28 with an increment in dosage of DMAP from 0 to 10 mg. The influence of DMAP/DCC on the DS of sulfated derivatives was depended on the content of DMAP. The effect of DMAP might be due to its strong coordination to the hydroxy group. The results of FT-IR and X-ray photoelectron spectroscopy (XPS) indicated that SO3- group (S6+, binding energy of 172.3 eV) was widely present in sulfated polysaccharide molecules. 13C NMR results indicated that C-6 substitution was predominant for sulfated polysaccharide when compared with other positions. In the sulfation reaction, a sharp decrease in MW was observed. DMAP/DCC was an effective catalyst system in sulfated modification of polysaccharide.
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: nuno-vai@163.com.
authors.forename: Junlong
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: xixi-long@163.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Yang
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: wyq127127@126.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: wangjunlong82@gmail.com.
authors.forename: Xiaonuo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: wangjunlong82@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: wangjunlong82@icloud.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Tian
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: yaojian@nwnu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
authors.affiliation: College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: nuno-vai@hotmail.com.cn.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: leizq@nwnu.edu.cn.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Lei
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D011134:Polysaccharides; D013431:Sulfates
keywords: Catalytic synthesis; Polysaccharides; Sulfation