title: Ten-year incidence of colorectal cancer following a negative screening sigmoidoscopy: an update from the Colorectal Cancer Prevention (CoCaP) programme.
abstract: OBJECTIVE
  To examine the rates of colorectal cancer (CRC) following a negative screening sigmoidoscopy.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  An integrated healthcare delivery organisation in California, USA.
  
  
  METHODS
  72,483 men and women aged 50 years and above who had a negative screening sigmoidoscopy between 1994 and 1996. Those at elevated risk of CRC due to inflammatory bowel disease, prior polyps or CRC, or a strong family history of CRC were excluded.
  
  
  METHODS
  Incidence rates of distal and proximal CRC. Standardised Incidence Ratios were used to compare annual incidence rates of distal and proximal CRC in the cohort to expected rates based on Surveillance, Epidemiology, and End Results data. Additionally, rate ratios (RR) and rate differences (RD) comparing the incidence rate of distal CRC in years 6+ postscreening with that in years 1-5 were calculated.
  
  
  RESULTS
  Incidence rates of distal CRC were lower than those in the San Francisco Bay area population at large during each of the first 10 years postsigmoidoscopy screening. However, the incidence of distal CRC rose steadily, from 3 per 100,000 in the first year of follow-up to 40 per 100,000 in the 10th year. During the second half of follow-up, the rate of distal CRC was twice as high as in the first half (RR 2 .08, 95% CI 1.38 to 3.16; RD 14 per 100,000 person-years, 95% CI 6 to 22).
  
  
  CONCLUSIONS
  Though still below population levels, the incidence of CRC during years 6-10 following a negative sigmoiodoscopy is appreciably higher than during the first 5 years.
authors.affiliation: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: V Paul
authors.initials: VP
authors.lastname: Doria-Rose
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California, USA Department of Gastroenterology, Kaiser Permanente Northern California, Walnut Creek, California, USA.
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Levin
authors.affiliation: Department of Gastroenterology, Kaiser Permanente Northern California, Walnut Creek, California, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Palitz
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Conell
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, Washington, USA Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Noel S
authors.initials: NS
authors.lastname: Weiss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012812:Sigmoidoscopy; D013997:Time Factors
keywords: COLORECTAL CANCER; ENDOSCOPY; SCREENING