title: Interspecific introgressive origin of genomic diversity in the house mouse.
abstract: We report on a genome-wide scan for introgression between the house mouse (Mus musculus domesticus) and the Algerian mouse (Mus spretus), using samples from the ranges of sympatry and allopatry in Africa and Europe. Our analysis reveals wide variability in introgression signatures along the genomes, as well as across the samples. We find that fewer than half of the autosomes in each genome harbor all detectable introgression, whereas the X chromosome has none. Further, European mice carry more M. spretus alleles than the sympatric African ones. Using the length distribution and sharing patterns of introgressed genomic tracts across the samples, we infer, first, that at least three distinct hybridization events involving M. spretus have occurred, one of which is ancient, and the other two are recent (one presumably due to warfarin rodenticide selection). Second, several of the inferred introgressed tracts contain genes that are likely to confer adaptive advantage. Third, introgressed tracts might contain driver genes that determine the evolutionary fate of those tracts. Further, functional analysis revealed introgressed genes that are essential to fitness, including the Vkorc1 gene, which is implicated in rodenticide resistance, and olfactory receptor genes. Our findings highlight the extent and role of introgression in nature and call for careful analysis and interpretation of house mouse data in evolutionary and genetic studies.
authors.affiliation: Department of Computer Science and nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Liu
authors.affiliation: Department of Computer Science and.
authors.forename: Ethan
authors.initials: E
authors.lastname: Steinberg
authors.affiliation: Department of Computer Science and.
authors.forename: Alexander
authors.initials: A
authors.lastname: Yozzo
authors.affiliation: BioSciences, Rice University, Houston, TX 77005.
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.affiliation: BioSciences, Rice University, Houston, TX 77005 nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kohn
authors.affiliation: Department of Computer Science and BioSciences, Rice University, Houston, TX 77005 nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.
authors.forename: Luay
authors.initials: L
authors.lastname: Nakhleh
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D014644:Genetic Variation; D016678:Genome / Q000235:genetics*; D005843:Geography; D006238:Haploidy; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D013045:Species Specificity
keywords: Mus musculus; Mus spretus; PhyloNet-HMM; adaptive introgression; hybridization