title: A review of the synthesis of α-carbolines.
abstract: Since the first reported synthesis of an α-carboline almost a century ago, there has been a steady interest in the development of strategies towards this unique heterocyclic motif. This interest can mainly be attributed to a range of biological activity displayed by the α-carboline natural products including cytotoxicity, anticancer properties or CNS activity. Numerous studies have led to the development of a number of alternative methods to prepare simple α-carbolines as well as a range of synthetic α-carboline derived compounds.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Wadsworth
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
authors.forename: Briar J
authors.initials: BJ
authors.lastname: Naysmith
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, c/o The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address: m.brimble@auckland.ac.nz.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans
chemical_list: D001688:Biological Products; D002243:Carbolines; C055571:alpha-carboline
keywords: Carboline; Grossularine; Mescengricin