title: Laparoscopic versus open surgery for rectal cancer: a systematic review and meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  Laparoscopic and open rectum surgery for rectal cancer remains controversial. This systematic review compared the short-term and long-term efficiency and complications associated with laparoscopic and open resection for rectal cancer.
  
  
  METHODS
  We searched PubMed, Embase, Cochrane Library, ISI Web of Knowledge and the China Biology Medicine Database to identify potential randomized controlled trials from their inception to March 31, 2014 without language restriction. Additional articles were identified from searching bibliographies of retrieved articles. Two reviewers independently assessed the full-text articles according to the pre-specified inclusion and exclusion criteria as well as the methodological quality of included trials. The meta-analysis was performed using RevMan 5.2.
  
  
  RESULTS
  A total of 16 randomized controlled trials involving 3,045 participants (laparoscopic group, 1,804 cases; open group, 1,241 cases) were reviewed. Laparoscopic surgery was associated with significantly lower intraoperative blood loss, earlier return of bowel movement and reduced length of hospital stay as compared to open surgery, although with increased operative time. It also showed an obvious advantage for minimizing late complications of adhesion-related bowel obstruction. Importantly, there were no significant differences in other postoperative complications, oncological clearance, 3-year and 5-year or 10 year recurrence and survival rates between two procedures.
  
  
  CONCLUSIONS
  On the basis of this meta-analysis we conclude that laparoscopic surgery has advantages of earlier postoperative recovery, less blood loss and lower rates of adhesion-related bowel obstruction. In addition, oncological outcome is comparable after laparoscopic and open resection for rectal cancer.
authors.affiliation: The First Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China E-mail : yangkh2006@163.com.
authors.forename: Feng-Wa
authors.initials: FW
authors.lastname: Zhang
authors.forename: Zhao-Yu
authors.initials: ZY
authors.lastname: Zhou
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Wang
authors.forename: Jv-Xia
authors.initials: JX
authors.lastname: Zhang
authors.forename: Bao-Shan
authors.initials: BS
authors.lastname: Di
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Huang
authors.forename: Ke-Hu
authors.initials: KH
authors.lastname: Yang
mesh_terms: D013505:Digestive System Surgical Procedures / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D011183:Postoperative Complications; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000601:surgery*