title: Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat.
abstract: The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat.
authors.forename: Qunhui
authors.initials: Q
authors.lastname: Li
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Hao
authors.forename: Zhao
authors.initials: Z
authors.lastname: Gao
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Sun
authors.forename: Jiao
authors.initials: J
authors.lastname: Hu
authors.forename: Shunlin
authors.initials: S
authors.lastname: Hu
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China. xfliu@yzu.edu.cn.
authors.forename: Xiufan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D002681:China; D006168:Guinea Pigs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics* / Q000378:metabolism; D009980:Influenza A virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D008969:Molecular Sequence Data; D009081:Mucolipidoses / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D058873:Pandemics / Q000662:veterinary*; D011201:Poultry Diseases / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus