title: Development of tumor lysis syndrome (TLS): A potential risk factor in cancer patients receiving anticancer therapy.
abstract: Tumor lysis syndrome (TLS) is characterized by hyperuricaemia, hyperphosphatemia, hyperkalaemia, as well as hypocalcaemia due to the breakdown of tumor cells undergoing cancer therapy (chemo/radio). Therefore it is of interest to evaluate oxidative stress using selective biological markers [Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT)] in TLS. We report the marked differences (statistically significant with control) observed among a selected set of biomarkers of oxidative stress (MDA = 8.66±1.37; SOD = 0.15±0.11; GSH = 2.25±.77; CAT = 0.76±.57) in TLS patients in addition to other conventional biomarkers. Moreover, correlation was investigated among the parameters of oxidative stress and other circulating biomarkers of TLS. Data suggest the use of SOD, MDA, and GSH as potential diagnostic biomarker for TLS with other biomarkers.
authors.affiliation: Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rasool
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan.
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan.
authors.forename: Muhammad Saeed
authors.initials: MS
authors.lastname: Qureshi
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan.
authors.forename: Riaz
authors.initials: R
authors.lastname: Ahmad
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Manan
authors.affiliation: Department of Biotechnology and Informatics, BUITEMS, Quetta, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Asif
authors.affiliation: Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Naseer
authors.affiliation: Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Peter Natesan
authors.initials: PN
authors.lastname: Pushparaj
keywords: GSH; MDA; SOD; Tumor lysis syndrome (TLS); hyperkalaemia; hyperphosphatemia; hyperuricaemia; hypocalcaemia; oxidative stress