title: Efficacy of sublingual immunotherapy for house dust mite allergic rhinitis.
abstract: In the present study, we investigated the outcomes of sublingual immunotherapy (SLIT) in house dust mite-induced allergic rhinitis (HDM-AR) patients. In this prospective, multicentric study, 186 patients with AR who had positive skin prick test results for HDMs were included. The patients were administered SLIT using Staloral 300 for 1 year. Evaluation of the patients regarding symptom scores, clinical findings and Rhinitis Quality of Life Questionnaire (RQLQ) scores was performed at baseline, and then at 6 and 12 months of therapy. Our results showed that, for all of the evaluated items (symptom scores, clinical findings and RQLQ scores), 12-month values were significantly lower than those at 6 months and baseline. Similarly, 6-month values were significantly lower than those at baseline. There were no complications in any of our patients. SLIT for HDM-AR is a treatment modality that can be used safely. We obtained better results than expected, and the treatment showed a positive psychological effect; the patients believed that SLIT was the final step of treatment and, which made them feel better.
authors.affiliation: ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Cingi
authors.affiliation: ENT Department, Medical Faculty, Kırıkkale University, Kırıkkale, Turkey. nbayarmuluk@yahoo.com.
authors.forename: Nuray
authors.initials: N
authors.lastname: Bayar Muluk
authors.affiliation: ENT Clinics, Gaziosmanpaşa Taksim Ilkyardım Training and Research Hospital, TR Ministry of Health, Istanbul, Turkey.
authors.forename: Seçkin
authors.initials: S
authors.lastname: Ulusoy
authors.affiliation: ENT Clinics, Yunus Emre State Hospital, TR Ministry of Health, Eskisehir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acar
authors.affiliation: ENT Clinics, Derince Training and Research Hospital, TR Ministry of Health, Derince, Turkey.
authors.forename: Seher
authors.initials: S
authors.lastname: Şirin
authors.affiliation: ENT Clinics, Trabzon Training and Research Hospital, TR Ministry of Health, Trabzon, Turkey.
authors.forename: Bengü
authors.initials: B
authors.lastname: Çobanoğlu
authors.affiliation: ENT Clinics, Yunus Emre State Hospital, TR Ministry of Health, Eskisehir, Turkey.
authors.forename: Leman
authors.initials: L
authors.lastname: Birdane
authors.affiliation: ENT Department, Medical Faculty, Başkent University, Istanbul, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Kalaycık
authors.affiliation: Anatomica Ear Nose Throat Clinic, Istanbul, Turkey.
authors.forename: Burak Ömür
authors.initials: BÖ
authors.lastname: Çakır
authors.affiliation: ENT Department, Medical Faculty, Kütahya Dumlupınar University, Kütahya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Oğhan
authors.affiliation: ENT Clinics, Eskişehir State Hospital, TR Ministry of Health, Eskisehir, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Aynacı
authors.affiliation: ENT Clinics, Osmaniye State Hospital, TR Ministry of Health, Osmaniye, Turkey.
authors.forename: Nagehan
authors.initials: N
authors.lastname: Erdoğmuş
authors.affiliation: ENT Clinics, Iğdır State Hospital, TR Ministry of Health, Iğdır, Turkey.
authors.forename: Ömürsen
authors.initials: Ö
authors.lastname: Yıldırım
authors.affiliation: ENT Clinics, Bayındır İstanbul Hospital, Istanbul, Turkey.
authors.forename: Ethem
authors.initials: E
authors.lastname: Şahin
authors.affiliation: ENT Clinics, Diyarbakır Memorial Hospital, Diyarbakır, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Bulut
authors.affiliation: ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Aksoy
authors.affiliation: ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Türe
authors.affiliation: Biostatistics Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Bal
mesh_terms: D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D039981:Pyroglyphidae / Q000276:immunology*; D011788:Quality of Life; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D063729:Sublingual Immunotherapy; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D039741:Antigens, Dermatophagoides
keywords: Allergic rhinitis (AR); House dust mite (HDM); Rhinitis Quality of Life Questionnaire (RQLQ); Sublingual immunotherapy (SLIT)