title: Investigating the anti-leishmanial effects of linear peptoids.
abstract: Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids. Peptoids were identified as having promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.
authors.affiliation: Biophysical Sciences Institute, Department of Chemistry, Durham University, South Road, Durham, DH1 3LE (UK).
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Eggimann
authors.forename: Hannah L
authors.initials: HL
authors.lastname: Bolt
authors.forename: Paul W
authors.initials: PW
authors.lastname: Denny
authors.forename: Steven L
authors.initials: SL
authors.lastname: Cobb
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D056945:Hep G2 Cells; D006801:Humans; D007894:Leishmania mexicana / Q000187:drug effects*; D034444:Peptoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D034444:Peptoids
keywords: Leishmania; anti-leishmanial agents; antiparasitic agents; peptoids