title: Enhanced in vivo delivery of 5-fluorouracil by ethosomal gels in rabbit ear hypertrophic scar model.
abstract: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 ± 1 °C had a better size stability than that at 25 ± 1 °C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future.
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025,China. woyansh@gmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wo
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. zhangzheng958@gmail.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. zhangyixin6688@163.com.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. zz6503@126.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China. wk_xa@163.com.
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China. mxh578694@163.com.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. rosiewudi@163.com.
authors.forename: Weijie
authors.initials: W
authors.lastname: Su
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. 18817821624@163.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China. dxcui@sjtu.edu.cn.
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
authors.affiliation: Department of Orthopaedic Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. biochenjun@fudan.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage*; D002460:Cell Line; D002626:Chemistry, Pharmaceutical; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004355:Drug Stability; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005782:Gels; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008081:Liposomes; D011817:Rabbits
chemical_list: D000963:Antimetabolites; D024042:Collagen Type I; D005782:Gels; D007166:Immunosuppressive Agents; D008081:Liposomes; D005472:Fluorouracil