title: CO2 laser treatment for regional cutaneous malignant melanoma metastases.
abstract: BACKGROUND
  Cutaneous in-transit and satellite metastases are distressing presentations of melanoma progression.
  
  
  OBJECTIVE
  The purpose of this study was to analyze the efficacy of carbon dioxide (CO2) lasers in patients with melanoma with cutaneous in-transit and satellite metastases.
  
  
  METHODS
  Results of CO2 laser therapy were retrospectively evaluated in 22 patients between January 2004 and January 2008. The number of laser treatments, postoperative morbidity, regional control, and overall survival were analyzed.
  
  
  RESULTS
  Twenty-two patients received a total of 42 CO2 laser treatments. The number of lesions treated per session varied from 3 to 329. The median duration of regional control in all patients was 14 weeks (range, 3-117). In 9 of 22 patients, only 1 treatment with CO2 laser was performed resulting in a mean regional control of 11 weeks. In 10 patients, an average of 4 laser treatments (range, 1-17) was necessary to achieve regional control. Three of the 22 patients underwent isolated limb perfusion after laser treatment for disease control.
  
  
  CONCLUSIONS
  This study shows that (repeated) laser treatment can achieve adequate regional control with little morbidity. CO2 laser is recommended as a first-line treatment to patients with small but numerous cutaneous satellite or in-transit lesions in whom other surgery would induce substantial morbidity.
authors.affiliation: *All the authors are affiliated with Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
authors.forename: Jorien A
authors.initials: JA
authors.lastname: van Jarwaarde
authors.forename: Ronnie
authors.initials: R
authors.lastname: Wessels
authors.forename: Omgo E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: Michel W J M
authors.initials: MW
authors.lastname: Wouters
authors.forename: Jos A
authors.initials: JA
authors.lastname: van der Hage
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology* / Q000556:secondary / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome