title: Photoinduced DNA damage and cytotoxicity by a triphenylamine-modified platinum-diimine complex.
abstract: Many planar photosensitizers tend to self-aggregate via van der Waals interactions between π-conjugated systems. The self-aggregation of the photosensitizer may reduce the efficiency of the photosensitizer to generate singlet oxygen, thereby diminishing its photodynamic activity. Efforts have been made to improve the photodynamic activity of bis-(o-diiminobenzosemiquinonato)platinum(II) which has planar geometry by the introduction of the sterically hindered triphenylamine moiety into the ligand. Herein we report the photoinduced DNA damage and cytotoxicity by a triphenylamine-modified platinum-diimine complex in red light studied by fluorescence spectra, agarose gel assay and cell viability assay. The results suggest that the triphenylamine-modified platinum-diimine complex has better capability to generate singlet oxygen than bis-(o-diiminobenzosemiquinonato)platinum(II), and it can induce DNA damage in red light, causing high photocytotoxicity in HepG-2 cells in vitro.
authors.affiliation: Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address: zgzhang@sxu.edu.cn.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Ruihui
authors.initials: R
authors.lastname: Dai
authors.affiliation: Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Shuying
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Wei
authors.affiliation: Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Wang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D004249:DNA Damage; D056945:Hep G2 Cells; D006801:Humans; D008027:Light; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000814:Aniline Compounds; D003603:Cytotoxins; D017319:Photosensitizing Agents; D010984:Platinum
keywords: Cell viability; DNA damage; Photodynamic therapy; Platinum diimine complex; Triphenylamine