title: New weapon in fighting atherosclerosis: effective inhibition of circulating low density lipoprotein cholesterol.
abstract: Last but not least a warning. Cholesterol is not only a pathogenic metabolite, it is an essential biological component. Indiscriminate cholesterol lowering may be inappropriate and harmful. The more effective is a weapon, the higher is the potential for a collateral damage (Fig. 1, Ref. 10).
authors.forename: E
authors.initials: E
authors.lastname: Ginter
authors.forename: V
authors.initials: V
authors.lastname: Simko
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000097:blood* / Q000188:drug therapy*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011973:Receptors, LDL / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D011973:Receptors, LDL; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases; C577155:evolocumab