title: Biosynthesis of integric acid isolated from the wood-decay fungus Xylaria feejeensis 2FB-PPM08M.
abstract: The biosynthesis of integric acid, a secondary metabolite of the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M, has been studied. Labeling experiments using [1-(13)C], [2-(13)C] and [1,2-(13)C2] acetate and L-methionine (methyl-(13)C) were separately performed with fungal culture. The labeling patterns of these metabolites indicated the same origin, and determined that integric acid was formed through the condensation of a sesquiterpene and a polyketide. These experiments showed that side chain of compounds would be synthesized by the polyketide pathway, while the ring carbon indicated the biosynthesis of compounds via the mevalonate pathway.
authors.affiliation: Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand, vhonas@yahoo.com.
authors.forename: Totsaporn
authors.initials: T
authors.lastname: Srisapoomi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ichiyanagi
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Nakajima
authors.forename: Tadanori
authors.initials: T
authors.lastname: Aimi
authors.forename: Sophon
authors.initials: S
authors.lastname: Boonlue
mesh_terms: D000085:Acetates / Q000378:metabolism; D002247:Carbon Isotopes / Q000378:metabolism; D002264:Carboxylic Acids / Q000378:metabolism*; D007553:Isotope Labeling; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008715:Methionine / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D009281:Naphthalenes / Q000378:metabolism*; D061065:Polyketides / Q000378:metabolism; D012717:Sesquiterpenes / Q000378:metabolism; D013098:Xylariales / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000085:Acetates; D002247:Carbon Isotopes; D002264:Carboxylic Acids; D009281:Naphthalenes; D061065:Polyketides; D012717:Sesquiterpenes; C120097:integric acid; D008715:Methionine; D008798:Mevalonic Acid