title: Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction.
abstract: Phosphaturic mesenchymal tumour is an extremely rare mesenchymal neoplasm of bone or soft tissue. It is associated with paraneoplastic oncogenic osteomalacia through secretion of fibroblast growth factor-23 (FGF-23) which inhibits renal proximal tubule phosphate re-uptake. We report a case of a 36-year-old woman with a large chest wall tumour completely excised by extensive chest wall resection and reconstruction with polypropylene mesh-methylmethacrylate composite and pedicled muscle flaps.
authors.affiliation: Department of Thoracic Surgery, 1st Floor Stratford House, Birmingham Heartlands Hospital, Bordesley Green, Birmingham, B9 5SS, UK. l.okiror@doctors.org.uk.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Okiror
authors.affiliation: Department of Oncoplastic and Reconstructive Surgery, Solihull Hospital, Birmingham, UK.
authors.forename: Haitham
authors.initials: H
authors.lastname: Khalil
authors.affiliation: Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham, UK.
authors.forename: Sumathi
authors.initials: S
authors.lastname: Vaiyapuri
authors.affiliation: Department of Thoracic Surgery, 1st Floor Stratford House, Birmingham Heartlands Hospital, Bordesley Green, Birmingham, B9 5SS, UK.
authors.forename: Maninder
authors.initials: M
authors.lastname: Kalkat
mesh_terms: D000328:Adult; D018786:Bone Substitutes / Q000627:therapeutic use; D005260:Female; D000089703:Fibroblast Growth Factor-23; D006801:Humans; D009372:Neoplasms, Connective Tissue / Q000601:surgery*; D010710:Phosphates / Q000378:metabolism; D011126:Polypropylenes / Q000627:therapeutic use; D012272:Ribs / Q000601:surgery; D013524:Surgical Flaps; D013899:Thoracic Neoplasms / Q000601:surgery*; D035441:Thoracic Wall / Q000601:surgery; D013905:Thoracoplasty / Q000379:methods
chemical_list: D018786:Bone Substitutes; C000717427:FGF23 protein, human; D010710:Phosphates; D011126:Polypropylenes; D000089703:Fibroblast Growth Factor-23
keywords: Phosphaturic mesenchymal tumour