title: A prospective study of villous capillary lesions in complicated pregnancies.
abstract: The vascularity of placental tissue is dependent on various factors of which fetomaternal hypoxia plays a major role. Hypoxia can be of different types and each type influences the vascularity of the villi, especially terminal villi, in its own way. In this study, we attempted to identify villous vascular changes in a group of term placentae from mothers with diseases complicating pregnancy. Chorangiosis was the most frequently identified lesion while chorangioma was found in only 2 cases. There were no cases of chorangiomatosis. A few cases had normal villous vasculature. Maternal diseases have a major role in disrupting the placental vasculogenesis and angiogenesis by creating a hypoxic environment that may affect the fetus adversely. Hence, such conditions need to be identified early in pregnancy and managed appropriately as it is possible to maintain a normal vasculature and prevent neonatal mortality and morbidity if prompt intervention is done.
authors.affiliation: Department of Pathology, Sree Balaji Medical College and Hospital, Bharath University, Chennai, Tamil Nadu 600 044, India.
authors.forename: Anu Priyadharshini
authors.identifier: 0000-0002-3251-7069
authors.initials: AP
authors.lastname: Srinivasan
authors.affiliation: Department of Pathology, Sree Balaji Medical College and Hospital, Bharath University, Chennai, Tamil Nadu 600 044, India.
authors.forename: B O Parijatham
authors.initials: BO
authors.lastname: Omprakash
authors.affiliation: Department of Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Bharath University, Chennai, Tamil Nadu 600 044, India.
authors.forename: Kandhimalla
authors.initials: K
authors.lastname: Lavanya
authors.affiliation: Department of Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Bharath University, Chennai, Tamil Nadu 600 044, India.
authors.forename: Priyadharshini
authors.initials: P
authors.lastname: Subbulakshmi Murugesan
authors.affiliation: Department of Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Bharath University, Chennai, Tamil Nadu 600 044, India.
authors.forename: Saraswathi
authors.initials: S
authors.lastname: Kandaswamy
mesh_terms: D001724:Birth Weight; D002196:Capillaries / Q000473:pathology*; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000098:blood supply* / Q000473:pathology; D016640:Diabetes, Gestational / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000473:pathology; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D011446:Prospective Studies