title: [Use of memantine for elderly patients in the mild stage of Alzheimer's and vascular dementia].
abstract: To evaluate the efficiency menantine (antagonist of NMDA-type glutamate receptor) for treatment of the mild stage of Alzheimer and vascular dementia, we conducted a comprehensive neurological, experimental psychological, neurophysiological examination of 33 patients. It was found that the treatment course with memantine, 5-10 mg daily during 3 months resulted in reducing the severity of cognitive impairment, improved bioelectric activity of the brain in patients with dementia, and also helped to improve the patients' behavior, which resulted in stress loads on the surrounding people. It is shown that the treatment was well tolerated, and memantine may be recommended as one of the drugs for treatment of cognitive impairment accompanying aging in the mild stage of dementia of different genesis.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Bachyns'ka
authors.forename: I F
authors.initials: IF
authors.lastname: Rozheliuk
authors.forename: K M
authors.initials: KM
authors.lastname: Polietaieva
authors.forename: V O
authors.initials: VO
authors.lastname: Kholin
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D003072:Cognition Disorders / Q000517:prevention & control* / Q000523:psychology; D015140:Dementia, Vascular / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D004334:Drug Administration Schedule; D004569:Electroencephalography; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012720:Severity of Illness Index
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D008559:Memantine