title: The synthesis of UDP-selective fluorescent probe and its imaging application in living cells.
abstract: A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn(2+) ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
authors.forename: Srinivasulu
authors.initials: S
authors.lastname: Kambam
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
authors.forename: Xintong
authors.initials: X
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, School of Life Science and Technology, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: chenhaiyan@cpu.edu.cn.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China. Electronic address: chenxq@njtech.edu.cn.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Chen
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006801:Humans; D018613:Microscopy, Confocal; D015394:Molecular Structure; D010569:Perylene / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014530:Uridine Diphosphate / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D014530:Uridine Diphosphate; D010569:Perylene; D015032:Zinc
keywords: Cell imaging; Fluorescent probe; Perylene; UDP