title: Proteins from the 18 glycosyl hydrolase family are associated with kidney dysfunction in patients with diabetes type 2.
abstract: OBJECTIVE
  To investigate chitotriosidase (CHIT1) activity and chitinase-3-like protein 1 (YKL-40) concentration in plasma of type 2 diabetic patients and evaluate their relationship with kidney dysfunction.
  
  
  METHODS
  94 diabetic subjects and 33 controls were enrolled in the study. Plasma CHIT1 activity and YKL-40 concentration were measured along with routine laboratory parameters.
  
  
  RESULTS
  Levels of CHIT1 and YKL-40 in plasma of type 2 diabetic patients increased progressively with the degree of albuminuria. CHIT1 discriminated normoalbuminuric subjects from those with abnormal albuminuria better than YKL-40.
  
  
  CONCLUSIONS
  CHIT1represent a supportive biomarker connected with development of diabetic vascular complications, especially kidney dysfunction.
authors.affiliation: Department of Pharmaceutical Biochemistry, Wroclaw Medical University , Wroclaw , Poland .
authors.forename: Ewa
authors.initials: E
authors.lastname: Żurawska-Płaksej
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Ługowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Hetmańczyk
authors.forename: Maria
authors.initials: M
authors.lastname: Knapik-Kordecka
authors.forename: Rajmund
authors.initials: R
authors.lastname: Adamiec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Piwowar
mesh_terms: D054392:Adipokines / Q000097:blood*; D000368:Aged; D000419:Albuminuria / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D006596:Hexosaminidases; C086400:chitotriosidase
keywords: Albuminuria; YKL-40; biomarker; chitotriosidase; diabetes mellitus; diabetic nephropathy