title: SnapShot: nucleic acid immune sensors, part 1.
abstract: The innate immune system has evolved sensors that can detect specific molecular fingerprints of non-self RNA or DNA. At the same time, some receptors respond to nucleic acids of both exogenous and endogenous origin, yet they are spatially segregated from endogenous nucleic acids. This SnapShot schematizes families and individual members of nucleic acid sensors with a focus on their ligands and the signaling pathways they employ.
authors.affiliation: Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.
authors.forename: Veit
authors.initials: V
authors.lastname: Hornung
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004279:DNA, Viral / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D012367:RNA, Viral / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D000099197:STING Protein
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004279:DNA, Viral; D008565:Membrane Proteins; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; C505371:MAVS protein, human; C532857:STING1 protein, human; D000099197:STING Protein