title: Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry.
abstract: Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting-group-free synthesis using organolithium compounds and opens a new possibility in the synthesis of polyfunctional organic molecules.
authors.affiliation: Department of Synthetic and Biologycal Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan) http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/index_e.html.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.forename: Keita
authors.initials: K
authors.lastname: Imai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishiuchi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida
keywords: chemoselectivity; flash chemistry; flow chemistry; microreactors; organolithium compounds