title: An ER clamp for endosome fission.
abstract: Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al, 2014) shows that contact sites between endosomes and the endoplasmic reticulum (ER) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endosomal sorting and maturation.
authors.affiliation: Centre for Cancer Biomedicine, Faculty of Medicine, Oslo University Hospital, Montebello Oslo, Norway Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello Oslo, Norway.
authors.forename: Camilla
authors.initials: C
authors.lastname: Raiborg
authors.affiliation: Centre for Cancer Biomedicine, Faculty of Medicine, Oslo University Hospital, Montebello Oslo, Norway Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello Oslo, Norway.
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D006801:Humans