title: Dermatomyositis and myastenia gravis: An uncommon association with therapeutic implications.
abstract: The association of dermatomyositis with myasthenia gravis (MG) is uncommon, having been reported so far in only 26 cases. We report the case of a 69 year-old man diagnosed with MG two years ago and currently treated with piridostigmyne. The patient developed acute proximal weakness, shoulder pain and elevated creatine-kinase (CK). He also developed generalized facial erythema and Gottron's papules. Laboratory tests showed positive antinuclear and anti-Mi2 antibodies. Further analysis confirmed CK levels above 1000 U/l. The clinical management of the patient and the therapeutic implications derived from the coexistence of both entities are discusssed.
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.
authors.forename: Clara
authors.initials: C
authors.lastname: Sangüesa Gómez
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.
authors.forename: Bryan Josué
authors.initials: BJ
authors.lastname: Flores Robles
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.
authors.forename: Clara
authors.initials: C
authors.lastname: Méndez Perles
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Barbadillo
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.
authors.forename: Hildegarda
authors.initials: H
authors.lastname: Godoy
authors.affiliation: Servicio de Reumatología, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España. Electronic address: jlandreu@arrakis.es.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Andréu
mesh_terms: D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D011729:Pyridostigmine Bromide / Q000627:therapeutic use
chemical_list: D002800:Cholinesterase Inhibitors; D007166:Immunosuppressive Agents; D011729:Pyridostigmine Bromide; D011241:Prednisone; D008727:Methotrexate
keywords: Dermatomiositis; Dermatomyositis; Inflammatory miopathies; Miastenia gravis; Miopatías inflamatorias; Myasthenia gravis