title: Lateral neck recurrence from papillary thyroid carcinoma: Predictive factors and prognostic significance.
abstract: OBJECTIVE
  The aim of this study was to identify any possible predictive factors of lateral neck recurrence in patients with papillary thyroid carcinoma with no ultrasonographic and/or cytological evidence of lymph node metastasis at time of diagnosis. The influence of lateral neck recurrence on survival was also investigated.
  
  
  METHODS
  Observational retrospective study.
  
  
  METHODS
  Retrospective review of clinical records of 610 patients surgically treated for papillary thyroid carcinoma with clinically negative lymph nodes at the Otolaryngology Unit of the Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, from January 1984 to December 2008.
  
  
  RESULTS
  Lateral neck recurrences were ipsilateral to the primary tumor in all cases and were associated with the occurrence of more aggressive histological variants and central neck metastasis. Lateral neck recurrences were more frequently observed in patients with distant metastases and were associated with a reduced disease-specific survival.
  
  
  CONCLUSIONS
  Lateral neck compartment ipsilateral to the tumor was the most common site of recurrence, with about half of cases appearing in the first 28 months of follow-up. In patients with papillary thyroid carcinoma, detection of lateral neck metastases prior to first surgery is crucial to surgical planning. Aggressive histological variants and postsurgical evidence of lymph node metastasis from papillary thyroid carcinoma in central neck compartment are associated with a higher risk of lateral neck recurrence. In these patients, a closer postsurgical ultrasound surveillance of the lateral neck compartments seems worthwhile.
  
  
  METHODS
  4.
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Giordano
authors.affiliation: Endocrinology Unit , Department of Surgery, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Frasoldati
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Jan L
authors.initials: JL
authors.lastname: Kasperbauer
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Gabrielli
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Pernice
authors.affiliation: Endocrinology Unit , Department of Surgery, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Zini
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Pedroni
authors.affiliation: Scientific Directorate, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Cavuto
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Verter
authors.initials: V
authors.lastname: Barbieri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D037981:Neck Dissection / Q000379:methods; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D055815:Young Adult
keywords: Lateral neck recurrence; follow-up; metastasis; papillary thyroid carcinoma