title: Using HLA typing to support patients with cancer.
abstract: BACKGROUND
  The human leukocyte antigen (HLA) system plays a crucial role in immune function, and HLA testing is often needed in the support of patients with cancer.
  
  
  METHODS
  We briefly review the published literature to clarify the nomenclature of the HLA system, currently available methods for HLA testing, and commonly used HLA assays. The uses of HLA testing in pharmacogenomics, disease association, platelet transfusion support, and in the management of both solid organ and hematopoietic stem cell transplantation are also reviewed.
  
  
  RESULTS
  HLA testing is commonly performed for select patient populations, including patients with cancer and in those requiring solid organ and hematopoietic stem cell transplantation.
  
  
  CONCLUSIONS
  Newer molecular typing methods have helped improve patient outcomes following hematopoietic stem cell transplantation.
authors.affiliation: Department of Pathology, Blood Bank and HLA Laboratory, University of Vermont Medical Center, Burlington, 05401, USA. Mark.Fung@vtmednet.org.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Fung
authors.forename: Kaaron
authors.initials: K
authors.lastname: Benson
mesh_terms: D006680:HLA Antigens / Q000145:classification* / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D016377:Organ Transplantation; D017713:Platelet Transfusion
chemical_list: D006680:HLA Antigens