title: Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?
abstract: Since the beginning of the last decade, exosomes have been of increased interest in the science community. Exosomes represent a new kind of long distance transfer of biological molecules among cells. This review provides a comprehensive overview about the construction of exosomes, their targeting and their fusion mechanisms to the recipient cells. Complementarily, the current state of research regarding the cargo of exosomes is discussed. A particular focus was placed on the role of exosomes in the central nervous system. An increasing number of physiological processes in the brain could be associated with exosomes. In this context, it is becoming more apparent that exosomes are involved in several neurological and specifically neurodegenerative diseases. The treatment of these kinds of diseases is often difficult not least because of the blood-brain barrier. Exosomes are very stable, can pass the blood-brain barrier and, therefore, reveal bright perspectives towards diagnosis and therapeutic treatments. A prerequisite for clinical applications is a standardised approach. Features necessary for a standardised diagnosis using exosomes are discussed. In therapeutic terms, exosomes represent a promising drug delivery system able to pass the blood-brain barrier. One option to overcome the disadvantages potentially associated with the use of endogenous exosomes is the design of artificial exosomes. The artificial exosomes with a clearly defined therapeutic active cargo and surface marker ensuring the specific targeting to the recipient cells is proposed as a promising approach.
authors.affiliation: Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
authors.forename: Arian
authors.initials: A
authors.lastname: Aryani
authors.affiliation: Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. bernd.denecke@rwth-aachen.de.
authors.forename: Bernd
authors.initials: B
authors.lastname: Denecke
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000628:therapy
keywords: Artificial exosome; Diagnosis; Extracellular vesicles; MicroRNA; Multiple sclerosis; Neurodegenerative disease