title: Long-Term Mortality Rates in Acute De Novo Versus Acute-on-Chronic Heart Failure: From the Heart Function Assessment Registry Trial in Saudi Arabia.
abstract: OBJECTIVE
  The heart function assessment registry trial in Saudi Arabia (HEARTS) is a national multicenter project that compared de novo versus acute-on-chronic heart failure (ACHF).
  
  
  RESULTS
  This is a prospective registry in 18 hospitals in Saudi Arabia between October 2009 and December 2010. The study enrolled 2610 patients: 940 (36%) de novo and 1670 (64%) ACHF. Patients with ACHF were significantly older (62.2 vs 60 years), less likely to be males (64% vs 69%) or smokers (31.6% vs 36.7%), and more likely to have history of diabetes mellitus (65.7% vs 61.3%), hypertension (74% vs 65%), and severe left ventricular dysfunction (52% vs 40%). The ACHF group had a higher adjusted 3-year mortality rate (hazard ratio, 1.6; 95% confidence interval [CI] 1.3-2.0; P < .001).
  
  
  CONCLUSIONS
  Patients with ACHF had significantly higher long-term mortality rates than those with de novo acute heart failure (HF). Multidisciplinary HF disease management programs are highly needed for such high-risk populations.
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia khalidalhabib13@hotmail.com.
authors.forename: Khalid F
authors.initials: KF
authors.lastname: AlHabib
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Tarek
authors.initials: T
authors.lastname: Kashour
authors.affiliation: Prince Salman Heart Center, King Fahd Medical City, Riyadh, Saudi Arabia Cardiology Department, Tanta University, Tanta, Egypt.
authors.forename: Abdelfatah A
authors.initials: AA
authors.lastname: Elasfar
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hussam
authors.initials: H
authors.lastname: Alfaleh
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hersi
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Alshamiri
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fayez
authors.initials: F
authors.lastname: Alshaer
authors.affiliation: King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
authors.forename: Layth
authors.initials: L
authors.lastname: Mimish
authors.affiliation: Prince Sultan Cardiac Center, Riyadh, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Almasood
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia King Faisal Cardiac Center, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Waleed
authors.initials: W
authors.lastname: AlHabeeb
authors.affiliation: Madina Cardiac Center, Al Madina Al Monaoarah, Saudi Arabia.
authors.forename: Saleh
authors.initials: S
authors.lastname: AlGhamdi
authors.affiliation: Prince Sultan Cardiac Center, Hafouf, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ghabashi
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: KaziNur
authors.initials: K
authors.lastname: Asfina
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hani
authors.initials: H
authors.lastname: Altaradi
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Omar
authors.initials: O
authors.lastname: Alnobani
authors.affiliation: Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Nour
authors.initials: N
authors.lastname: Alkamel
authors.affiliation: Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait city, Kuwait.
authors.forename: Lukman
authors.initials: L
authors.lastname: Thalib
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D012737:Sex Factors; D013997:Time Factors
keywords: HEARTS; Saudi Arabia; acute heart failure; middle east; registry