title: Sirtuins as novel players in the pathogenesis of diabetes mellitus.
abstract: Diabetes mellitus (DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD(+) dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus.
authors.affiliation: Kultigin Turkmen, Division of Nephrology, Department of Internal Medicine, Erzincan University, 24000 Erzincan, Turkey.
authors.forename: Kultigin
authors.initials: K
authors.lastname: Turkmen
authors.affiliation: Kultigin Turkmen, Division of Nephrology, Department of Internal Medicine, Erzincan University, 24000 Erzincan, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Karagoz
authors.affiliation: Kultigin Turkmen, Division of Nephrology, Department of Internal Medicine, Erzincan University, 24000 Erzincan, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
keywords: Diabetes mellitus; Hyperglycemia; Hyperlipidemia; Resveratrol; Sirtuins