title: Effect of lipid parameters on foetal growth in gestational diabetes mellitus pregnancies.
abstract: BACKGROUND
  Women with gestational diabetes mellitus (GDM) often deliver newborns large for their gestational age (LGA). The aim of the study was to evaluate the effect of lipid parameters in the second half of pregnancy on foetal growth in GDM pregnancies.
  
  
  METHODS
  In two hundred consecutive women with GDM the age, body mass index before pregnancy, body mass index before delivery, gestational week of GDM diagnosis, lipid parameters after 24 weeks of pregnancy, fasting glycaemia, HbA1c in the second and third trimester of pregnancy, gestational age at delivery, mode of delivery, and baby birth weight were analyzed.
  
  
  RESULTS
  Of the 200 GDM pregnancies, 50 (25%) women delivered LGA newborns, 135 (67.5%) women delivered newborns appropriate for gestational age (AGA), and 15 (7.5%) women delivered newborns small for gestational age (SGA). Maternal triglyceride levels and HbA1c in the second trimester were higher, and HDL-C was significantly lower, in the LGA group than in the AGA group (3.8 ± 1.8 vs. 3.1 ± 1.1 mmol/L, 6.1 ± 1.1 vs. 5.5 ± 0.8%, and 1.3 ± 0.4 vs. 1.6 ± 0.4 mmol/L, p < 0.05). Also, maternal triglyceride levels and HbA1c in the second trimester were significantly higher in the SGA group than in the AGA group (3.8 ± 1.9 vs. 3.1 ± 1.1 mmol/L and 6.8 ± 0.8 vs. 5.5 ± 0.8%, p < 0.05). Maternal triglycerides were independent predictors for delivering LGA newborns in GDM women.
  
  
  CONCLUSIONS
  In GDM pregnancies, maternal triglycerides in the second half of pregnancy may indentify women who will deliver LGA newborns. Thus, with good regulation of lipid profile, we can avoid macrosomia from GDM pregnancies.
authors.affiliation: Medical Faculty, Obstetrics and Gynecology Clinic, Skopje, Macedonia.
authors.forename: Slagjana
authors.initials: S
authors.lastname: Simeonova-Krstevska
authors.forename: Brankica
authors.initials: B
authors.lastname: Krstevska
authors.forename: Valentina
authors.initials: V
authors.lastname: Velkoska-Nakova
authors.forename: Marija
authors.initials: M
authors.lastname: Hadji Lega
authors.forename: Igor
authors.initials: I
authors.lastname: Samardjiski
authors.forename: Vladimir
authors.initials: V
authors.lastname: Serafimoski
authors.forename: Vesna
authors.initials: V
authors.lastname: Livrinova
authors.forename: Irena
authors.initials: I
authors.lastname: Todorovska
authors.forename: Aneta
authors.initials: A
authors.lastname: Sima
mesh_terms: D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D036861:Delivery, Obstetric / Q000379:methods; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005320:Fetal Macrosomia / Q000453:epidemiology* / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides