title: [MicroRNA in prostate cancer].
abstract: MicroRNAs are small non-coding RNAs that negatively regulate gene expression post-transcriptionally. MicroRNA profiles have been studied in various cancers including prostate cancer since 2007. According to these results, microRNA signature in prostate cancer differed from their normal counterparts, suggesting that the differential expression of microRNAs in tumors functionally implicated in their pathogenesis. The up-regulation of oncogenic microRNA and down-regulation of tumor suppressor microRNA are demonstrated in various cancers. The target genes of microRNA identified include those of apoptosis avoidance, cell proliferation, epithelial mesenchymal transition, angiogenic signalling, and generation of androgen independence in prostate cancer. Elucidation of micro RNA function may provide further advance in diagnosis and treatment of prostate cancer.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs