title: A prospective longitudinal study of growth and pubertal progress in adolescents with inflammatory bowel disease.
abstract: BACKGROUND
  Puberty and growth may be affected in inflammatory bowel disease (IBD) but the extent is unclear.
  
  
  METHODS
  We performed a prospective study over 12 months in 63 adolescents (Crohn's disease, CD, n = 45; ulcerative colitis/IBD unclassified, UC, n = 18) with a median age of 13.4 years (range 10-16.6). Assessment included anthropometry, biochemical markers of growth and puberty and an assessment of quality of life by IMPACT-III.
  
  
  RESULTS
  Compared to the normal population, boys with CD were shorter, with a median height SDS (HtSDS) of -0.13 (-2.52 to 1.58; p < 0.05). In addition, the study cohort had a lower median IGF-1 SDS of -0.29 (-4.53 to 2.96; p = 0.008) and a higher median IGFBP3 SDS of 0.45 (-3.15 to 2.55; p = 0.002). Over the study period, the median Ht velocity (HV) was 5 cm/year (0.2-8.7) and the change in HtSDS was 0.06 (-0.48 to 0.57). The median difference between the chronological and bone age was 0.3 years (-2.5 to 3.0) and pubertal examination was not delayed. In the whole group, the erythrocyte sedimentation rate (ESR) showed an inverse association with HV (r = -0.29; p = 0.025) and IGF-1:IGFBP3 (r = -0.34; p = 0.016). The score in the body image domain, IMPACT-III, was inversely associated with HtSDS (r = -0.31; p = 0.03).
  
  
  CONCLUSIONS
  Despite no evidence of pubertal delay, adolescents with IBD display growth retardation which may be associated with raised ESR, adverse quality of life measures and an abnormality of IGF-1 bioavailability.
authors.affiliation: Child Health, School of Medicine, University of Glasgow, Royal Hospital for Sick Children, Glasgow, UK.
authors.forename: Avril
authors.initials: A
authors.lastname: Mason
authors.forename: Salma
authors.initials: S
authors.lastname: Malik
authors.forename: Martin
authors.initials: M
authors.lastname: McMillan
authors.forename: Jane D
authors.initials: JD
authors.lastname: McNeilly
authors.forename: J
authors.initials: J
authors.lastname: Bishop
authors.forename: Paraic
authors.initials: P
authors.lastname: McGrogan
authors.forename: Richard K
authors.initials: RK
authors.lastname: Russell
authors.forename: S Faisal
authors.initials: SF
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D011627:Puberty / Q000502:physiology*; D011788:Quality of Life
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I