title: Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades.
authors.affiliation: Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands.
authors.forename: Annelies
authors.initials: A
authors.lastname: Nijdam
authors.affiliation: Unitat Hemofilia Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Altisent
authors.affiliation: Division of Haematology/Oncology, Department of Paediatrics and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Manuel D
authors.initials: MD
authors.lastname: Carcao
authors.affiliation: Unidad de Hemostasia y Trombosis, Hospital Universitario la Fe, Valencia, Spain.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Cid
authors.affiliation: CHU Purpan Centre de traitement des hémophiles, Toulouse, France.
authors.forename: Ségolène
authors.initials: S
authors.lastname: Claeyssens-Donadel
authors.affiliation: Dr. von Haunersches Children's Hospital, University of Munich, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Kurnik
authors.affiliation: Lund University, Department of Clinical Sciences Lund -Paediatrics and Malmö Haemostasis & Thrombosis Centre, Skåne University Hospital, Malmö, Sweden.
authors.forename: Rolf
authors.initials: R
authors.lastname: Ljung
authors.affiliation: Department of Haematology Oncology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nolan
authors.affiliation: Paediatric Department of Coagulation Disorders, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Pia
authors.initials: P
authors.lastname: Petrini
authors.affiliation: St. Sophia Children's Hospital, Haemophilia-Haemostasis Unit, Athens, Greece.
authors.forename: Helen
authors.initials: H
authors.lastname: Platokouki
authors.affiliation: Centre Régional de Traitement de l'Hémophilie et Autres Maladies Hémorragiques, Centre Hospitalier Universitaire de Bicêtre, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Rafowicz
authors.affiliation: Department of Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland.
authors.forename: Angela E
authors.initials: AE
authors.lastname: Thomas
authors.affiliation: Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands k.fischer@umcutrecht.nl.
authors.forename: Kathelijn
authors.initials: K
authors.lastname: Fischer
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D005169:Factor VIII / Q000266:history / Q000627:therapeutic use*; D005260:Female; D006395:Hemarthrosis / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007596:Joints / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D016019:Survival Analysis; D061665:Time-to-Treatment
chemical_list: D005169:Factor VIII
keywords: bleeding; prophylaxis