title: Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene.
abstract: A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL and DOX can be sequentially released toward the plasma membrane and nucleus, respectively.
authors.affiliation: State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing, 210009, China; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
authors.forename: Tianyue
authors.initials: T
authors.lastname: Jiang
authors.forename: Wujin
authors.initials: W
authors.lastname: Sun
authors.forename: Qiuwen
authors.initials: Q
authors.lastname: Zhu
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Burns
authors.forename: Saad A
authors.initials: SA
authors.lastname: Khan
authors.forename: Ran
authors.initials: R
authors.lastname: Mo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D016207:Cytokines / Q000008:administration & dosage / Q000737:chemistry; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D045683:Furin / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000737:chemistry; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000008:administration & dosage / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D053769:Nanocapsules; D010087:Oxides; D010455:Peptides; D053221:TNF-Related Apoptosis-Inducing Ligand; D011092:Polyethylene Glycols; D006108:Graphite; D004317:Doxorubicin; D045683:Furin
keywords: cytokine; drug delivery; furin; graphene oxide; nanomedicine