title: Oral submucous fibrosis--a treatment protocol based on clinical study of 100 patients in central India.
abstract: OBJECTIVE
  Oral submucous fibrosis till date is a very poorly understood and unsatisfactorily treated disease with variable signs and symptoms. In this paper, we have classified the disease in different groups according to the clinical signs, radiological assessment, histopathological confirmation, progress, and severity of disease and proposed a treatment algorithm for effective treatment of the disease in 100 patients.
  
  
  METHODS
  In our study, we randomly selected 100 patients of oral submucous fibrosis and classified them in to five groups based on clinical symptoms and radiological and histopathological parameters. We have given specific treatment for each group and followed them up for 2 years regularly.
  
  
  RESULTS
  We found that almost all patients got symptomatic relief from the disease. Patient's interincisal mouth opening increased significantly. All patients can take regular diet. Progressive malignant transformation can be detected earlier to avoid future morbidity and mortality.
  
  
  CONCLUSIONS
  Oral submucous fibrosis (OSMF) scoring index is very effective to decide the severity of disease and progress. Based on this scoring and grouping we can give definite prompt treatment to the patients with satisfactory results. Such a way this proposed scoring and staging can play major role in controlling and treating this widespread global disease.
authors.affiliation: Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, India, drpravinlambade@gmail.com.
authors.forename: Pravin
authors.initials: P
authors.lastname: Lambade
authors.forename: Pawan
authors.initials: P
authors.lastname: Dawane
authors.forename: Pradip
authors.initials: P
authors.lastname: Thorat
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000465:Algorithms; D000975:Antioxidants / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003906:Developing Countries; D005260:Female; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009914:Oral Submucous Fibrosis / Q000145:classification / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D019647:Oral Surgical Procedures; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000975:Antioxidants