title: Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution.
abstract: Antibacterial and antioxidant monomethyl fumaric acid (MFA) was selected to modify chitosan, using aqueous solution of an ionic liquid as a homogeneous and green reaction media. The chemical structures of resulting polymers were systematically characterized by (1)H NMR, diffusion ordered spectroscopy, solid (13)C NMR and wide-angle X-ray diffraction. The results show that two kinds of MFA modified chitosan materials with totally different chemical structures have been synthesized. One product was a MF-chitosan salt composed of chitosan cation and MFA anion, which was obtained with the mediation of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide. The other one synthesized with the mediation of EDC was a MF-chitosan amide in which MFA and chitosan are covalently attached. Solubility of chitosan has been improved, and MF-chitosan salt can be readily dissolved in water. The antioxidant activity has been enhanced with the introduction of MFA, irrespective of the chemical structure.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Zhaodong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China. Electronic address: hubeizlc@iccas.ac.cn.
authors.forename: Liuchun
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China. Electronic address: lichch@iccas.ac.cn.
authors.forename: Chuncheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China.
authors.forename: Yaonan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China.
authors.forename: Guohu
authors.initials: G
authors.lastname: Guan
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, PR China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Zhu
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005650:Fumarates / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D012995:Solubility; D012996:Solutions
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005650:Fumarates; D052578:Ionic Liquids; D010851:Picrates; D012996:Solutions; C032005:fumaric acid; D048271:Chitosan; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Chitosan; Ionic liquid; Monomethyl fumaric acid