title: Physical and cardiovascular performance in cases with acromegaly after regular short-term exercise.
abstract: OBJECTIVE
  Impaired physical performance is a disturbing complication of acromegaly. We aimed to evaluate the role of regular exercise in amelioration of the impaired physical performance in acromegaly.
  
  
  METHODS
  Patients with acromegaly were divided into two groups according to their participation in a prescheduled programme of exercise. Participants in the study group were exercised 3 days a week for 3 consecutive months. Exercise tolerance was evaluated by maximal oxygen consumption (VO2 max) and time (T) taken to complete the Bruce protocol, muscle flexibility by the sit and reach test (SRT) and muscle strength by the hand grip strength test (HGST). Concomitantly, anthropometric assessment was performed using body mass index (BMI), waist-to-hip ratio (WHR), skinfold measurements from 8 points, percentage body fat (PBF), fat mass (FM) and lean body mass (LBM).
  
  
  RESULTS
  After 3 months of exercise, VO2 max and T were higher in cases that exercised than in cases that did not (P = 0.004 and P = 0.001). Over 3 months, within the exercise group, VO2 max and T of the Bruce protocol increased (P = 0.003 and P = 0.004) and heart rate during warming decreased (P = 0.04). SRT increased within the exercise group after 3 months (P = 0.004). HGSRT did not change significantly (right P = 0.06 and left P = 0.2). The sum of skinfolds, BMI, WHR and LBM remained stable over the study period (P = 0.1, P = 0.08, P = 0.3 and P = 0.09). PBF decreased slightly and FM decreased significantly over 3 months (P = 0.05 and P = 0.03).
  
  
  CONCLUSIONS
  Even short-term exercise may improve impaired physical performance, muscle activity and disturbed body fat composition in acromegaly.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Hatipoglu
authors.affiliation: Marmara University School of Physical Education and Sports, Istanbul, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Topsakal
authors.affiliation: Marmara University School of Physical Education and Sports, Istanbul, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Erkut Atilgan
authors.affiliation: Marmara University School of Physical Education and Sports, Istanbul, Turkey.
authors.forename: Asiye Filiz
authors.initials: AF
authors.lastname: Camliguney
authors.affiliation: Department of Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Ikitimur
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: Serdal
authors.initials: S
authors.lastname: Ugurlu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Niyazoglu
authors.affiliation: Marmara University School of Physical Education and Sports, Istanbul, Turkey.
authors.forename: Hasan Birol
authors.initials: HB
authors.lastname: Cotuk
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
mesh_terms: D000172:Acromegaly / Q000534:rehabilitation*; D000236:Adenoma / Q000628:therapy; D000273:Adipose Tissue; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001823:Body Composition; D015992:Body Mass Index; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000628:therapy; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D015282:Octreotide / Q000627:therapeutic use; D010101:Oxygen Consumption; D010456:Peptides, Cyclic / Q000627:therapeutic use; D010809:Physical Fitness; D016059:Range of Motion, Articular; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D049629:Waist-Hip Ratio
chemical_list: D018931:Antineoplastic Agents, Hormonal; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin; D015282:Octreotide