title: Cytomegalovirus: a culprit or protector in multiple sclerosis?
abstract: Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system (CNS). Cytomegalovirus (CMV), a β herpes virus, may have a detrimental or beneficial role in MS pathology. Accumulating evidence indicates that CMV contributes to MS disease via interplay of different mechanisms such as molecular mimicry, bystander activation, and epitope spreading. The activation and expansion of a specific T cell subset, CD4(+)CD28(null) T cells, via CMV infection could also contribute to MS pathology. Various additional observations also indicate a protective effect of CMV on autoimmune diseases. CMV immune evasion may mitigate the autoimmune reactions and proinflammatory milieu that contribute to MS.
authors.affiliation: Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium.
authors.forename: Marjan
authors.initials: M
authors.lastname: Vanheusden
authors.affiliation: Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium.
authors.forename: Piet
authors.initials: P
authors.lastname: Stinissen
authors.affiliation: Biomedical Primate Research Centre, Department of Immunobiology, Rijswijk, The Netherlands; University of Groningen, Department of Neuroscience, University Medical Center, Groningen, The Netherlands.
authors.forename: Bert A
authors.initials: BA
authors.lastname: 't Hart
authors.affiliation: Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium. Electronic address: niels.hellings@uhasselt.be.
authors.forename: Niels
authors.initials: N
authors.lastname: Hellings
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000382:microbiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
keywords: cytomegalovirus; multiple sclerosis