title: Four patients with Amanita Phalloides poisoning.
abstract: Mushroom poisoning by Amanita phalloides is a rare but potentially fatal disease. The initial symptoms of nausea, vomiting, abdominal pain and diarrhea, which are typical for the intoxication, can be interpreted as a common gastro-enteritis. The intoxication can progress to acute liver and renal failure and eventually death. Recognizing the clinical syndrome is extremely important. In this case report, 4 patients with amatoxin intoxication who showed the typical clinical syndrome are described. The current therapy of amatoxin intoxication is based on small case series, and no ran- domised controlled trials are available. The therapy of amatoxin intoxication consists of supportive care and medical therapy with silibinin and N-acetylcysteine. Patients who develop acute liver failure should be considered for liver transplantation.
authors.forename: S
authors.initials: S
authors.lastname: Vanooteghem
authors.forename: J
authors.initials: J
authors.lastname: Arts
authors.forename: S
authors.initials: S
authors.lastname: Decock
authors.forename: P
authors.initials: P
authors.lastname: Pieraerts
authors.forename: W
authors.initials: W
authors.lastname: Meersseman
authors.forename: C
authors.initials: C
authors.lastname: Verslype
authors.forename: Ph
authors.initials: P
authors.lastname: Van Hootegem
mesh_terms: D000368:Aged; D000545:Amanita; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*