title: Monoterpene indole alkaloids from the twigs of Kopsia arborea.
abstract: The phytochemistry of Kopsia arborea Blume has received considerable attention, which has resulted in the isolation of a number of new unusual indole alkaloids with intriguing structures. In this study, a new eburnane-type alkaloid, phutdonginin (1), together with eight known alkaloids: 19-OH-(-)- eburnamonine (2), melodinine E (3), kopsinine (4), kopsilongine (5), kopsamine (6), (-)-methylenedioxy-1 1,12-kopsinaline (7), decarbomethoxykopsiline (8), and vincadifformine (9), were isolated from the twigs of K. arborea. Their structures were characterized extensively by 1D and 2D NMR spectroscopy and HR-ESI-MS. All compounds were submitted to TLC screening for acetylcholinesterase inhibitory activities. Only kopsamine and decarbomethoxykopsiline showed AChE inhibition with MIR values of 12.5 and 6.25 μg, respectively, compared with galanthamine (positive control, 0.004 μg). In addition, compounds 1 and 2 inhibited moderate antibacterial activity against E. coli TISTR 780 with the MIC value of 32 .g/mL.
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Achara
authors.initials: A
authors.lastname: Raksat
authors.forename: Thunwadee
authors.initials: T
authors.lastname: Ritthiwigrom
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005702:Galantamine / Q000737:chemistry / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D026121:Indole Alkaloids; D039821:Monoterpenes; D046948:Secologanin Tryptamine Alkaloids; C000591794:melodinine E; D005702:Galantamine; C456406:vincadifformine; C061491:kopsinine