title: Lack of association of the cyclooxygenase-2 gene 8473T>C polymorphism with breast cancer risk: a meta-analysis.
abstract: BACKGROUND
  Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous. The aim of this meta-analysis was to comprehensively estimate the genetic risk of 8473T>C polymorphism in the COX-2 gene for BC.
  
  
  METHODS
  We searched PubMed, Web of Science, Medline, Chinese biomedical (CBM), Weipu, China national knowledge infrastructure (CNKI), and Wanfang databases, covering all publications (last search was updated on Aug 17, 2014). Statistical analyses were performed using Revman 5.3 and STATA 10.0 software.
  
  
  RESULTS
  A total of 6,720 cases and 9,794 controls in 12 studies were included in this study. The results indicated no significant associations between the 8473T>C polymorphism of the COX-2 gene and BC risk for the CC+TC vs TT model (pooled odds ratio (OR)=0.97, 95% confidence interval (CI)=0.90-1.03, and p=0.29). On subgroup analysis, we also found that subdivision on ethnicity among Caucasians, Asians and others also revealed no relationship with BC susceptibility. With the study design (CC+TC vs TT), no significant associations were found in either population-based case-control studies (PCC), or hospital-based case-control studies (HCC).
  
  
  CONCLUSIONS
  This present meta-analysis suggests that the 8473T>C polymorphism in the COX-2 gene is not a conspicuous low- penetrant risk factor for developing BC.
authors.affiliation: Department of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China E-mail : yicheng6834@163.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Fen
authors.initials: F
authors.lastname: Zhao
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Cheng
authors.initials: C
authors.lastname: Yi
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human