title: High number of memory t cells is associated with higher risk of acute graft-versus-host disease after allogeneic stem cell transplantation.
abstract: The pathophysiology of acute graft-versus-host disease (GVHD) remains poorly understood in humans. Although T cell subsets have been identified to play a major role in disease initiation in rodents, clinical data on the effect of these different subsets are scarce and conflicting. To address this question, immunophenotyping analyses were performed on the graft in 210 patients. The onset of acute GVHD was retrospectively correlated with these subpopulations. In an adjusted analysis, only the absolute count of CD45lo/CD62Llo CD8(+) T cells (effector memory T cells) was significantly associated with the onset of grade 2 to 4 acute GVHD. Thus, in contrast to experimental data, we found that the number of effector memory but not of naïve T cells was associated with the onset of GVHD. These results should be kept in mind while clinical trials, which aim to deplete naïve T cells, are underway in several institutions.
authors.affiliation: Centre Henri Becquerel, Hematology, Rouen, France; AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Loschi
authors.affiliation: AP-HP, Hotel-Dieu Hospital, Statistics, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Porcher
authors.affiliation: AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France; University Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France.
authors.forename: Regis
authors.initials: R
authors.lastname: Peffault de Latour
authors.affiliation: AP-HP, Saint-Louis Hospital, Cell Therapy Unit, Paris, France; Inserm UMR 1160 and Clinical Investigation Center in Biotherapies (CICBT501), Paris, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Vanneaux
authors.affiliation: AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.affiliation: AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France.
authors.forename: Alienor
authors.initials: A
authors.lastname: Xhaard
authors.affiliation: AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France; University Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France.
authors.forename: Flore
authors.initials: F
authors.lastname: Sicre de Fontebrune
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France; AP-HP, Saint-Louis Hospital, Cell Therapy Unit, Paris, France; Inserm UMR 1160 and Clinical Investigation Center in Biotherapies (CICBT501), Paris, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Larghero
authors.affiliation: AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France; University Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France; Inserm UMR 1160 and Clinical Investigation Center in Biotherapies (CICBT501), Paris, France. Electronic address: gerard.socie@sls.aphp.fr.
authors.forename: Gerard
authors.initials: G
authors.lastname: Socie
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007156:Immunologic Memory; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation
keywords: Acute graft-versus-host disease; Memory T cell; Naïve T cell; Stem cell transplantation