title: Rapid detection of hydrazine in a naphthol-fused chromenyl loop and its effectiveness in human lung cancer cells: tuning remarkable selectivity via the reaction altered pathway supported by theoretical studies.
abstract: Our designed and synthesized chemosensor naphthalene based chromenyl derivative (NAC) [1-(3-hydroxy-3 methyl-3H-benzo[f]chromen-2-yl) ethanone] has been used for fast (<30 s, DL = 0.22 ppb) and selective detection of N2H4 by a new way via the chromenyl ring opening followed by the pyrazole ring formation giving a strong blue fluorescence. The DFT study and the real application in different water samples along with the dipstick method in low cost devices have also been performed here. Human lung cancer cells (NCI-H460) have been used for hydrazinolysis of the NAC in vivo system for detection by the appearance of blue fluorescence and also for the MTT assay showing its remarkable cancer sensitivity.
authors.affiliation: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, West Bengal, India. spgoswamical@yahoo.com.
authors.forename: Shyamaprosad
authors.initials: S
authors.lastname: Goswami
authors.forename: Avijit Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Urmila
authors.initials: U
authors.lastname: Saha
authors.forename: Sibaprasad
authors.initials: S
authors.lastname: Maity
authors.forename: Kalyani
authors.initials: K
authors.lastname: Khanra
authors.forename: Nandan
authors.initials: N
authors.lastname: Bhattacharyya
mesh_terms: D002867:Chromones / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006834:Hydrazines / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence
chemical_list: D002867:Chromones; D006834:Hydrazines; D009284:Naphthols; C029424:hydrazine