title: Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles.
abstract: Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Zheshuo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address: 15159267@qq.com.
authors.forename: Xueying
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China.
authors.forename: Weiyue
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China. Electronic address: liuyu@fudan.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D001897:Boronic Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005260:Female; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000737:chemistry; D008813:Mice, Inbred ICR; D009077:Mucins / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D014621:Vagina / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism
chemical_list: D001897:Boronic Acids; D009077:Mucins; D007372:Interferons; C010686:benzeneboronic acid
keywords: Controlled release; Mucin; Mucoadhesion; Nanoparticle; Phenyboronic acid