title: Pseudozyma spp catheter-associated blood stream infection, an emerging pathogen and brief literature review.
abstract: Pseudozyma spp are amorphic yeasts. They are commonly plant pathogens, but rarely cause invasive fungal disease in humans. Only three cases of central venous catheter (CVC)-associated blood stream infections due to this organism have been reported in the literature. Main underlying risk factors for Pseudozyma spp infection are bowel surgery, CVC and total parenteral nutrition. We present a rare case of Pseudozyma spp catheter-associated blood stream infection that was successfully treated with antifungal therapy and removal of CVC. It is important to recognise and differentiate this species from other yeasts as it may require the use of amphotericin B or voriconazole instead of fluconazole, to which the organism is variably resistant.
authors.affiliation: Department of Infectious Diseases, Phoebe Putney Memorial Hospital, Albany, Georgia, USA.
authors.forename: Wajid
authors.initials: W
authors.lastname: Siddiqui
authors.affiliation: Department of Internal Medicine, Texas Tech University of Health Science Center, Odessa, Texas, USA.
authors.forename: Yasir
authors.initials: Y
authors.lastname: Ahmed
authors.affiliation: Department of Infectious Diseases, University of South Carolina, Columbia, South Carolina, USA.
authors.forename: Helmut
authors.initials: H
authors.lastname: Albrecht
authors.affiliation: Department of Infectious Diseases, University of South Carolina, Columbia, South Carolina, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Weissman
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D062905:Central Venous Catheters / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D012307:Risk Factors; D065819:Voriconazole / Q000627:therapeutic use; D015003:Yeasts
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D065819:Voriconazole