title: Four new furostanol saponins from the rhizomes and roots of Smilax scobinicaulis and their cytotoxicity.
abstract: Four new furostanol saponins 1-4, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (1), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-D-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines.
authors.affiliation: College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China. seaqisky@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, 160 Xianhu Road, Liantang, Shenzhen 518004, China. shixiufeng7787@gmail.com.
authors.forename: Shixiu
authors.initials: S
authors.lastname: Feng
authors.affiliation: College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China. wangqidream2006@163.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China. caoyinglisky@163.com.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Cao
authors.affiliation: College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China. sunmiao151@163.com.
authors.forename: Miao
authors.initials: M
authors.lastname: Sun
authors.affiliation: College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China. cunli_zhang@nwsuaf.edu.cn.
authors.forename: Cunli
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032281:Smilax / Q000737:chemistry; D052616:Solid Phase Extraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins