title: Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population.
abstract: Introduction : Obesity results from interaction between genetic and environmental risk factors.
  
  
  OBJECTIVE
  To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population.
  
  
  METHODS
  A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms ( UCP3- rs1800849, FTO -rs17817449, and CAPN10 -rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet.
  
  
  RESULTS
  A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10 ) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals.
  
  
  CONCLUSIONS
  In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Orozco
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Angélica M
authors.initials: AM
authors.lastname: Muñoz
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Velásquez
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Uscátegui
authors.affiliation: Grupo de Investigación GENMOL, Universidad de Antioquia, Medellín, Colombia.
authors.forename: María V
authors.initials: MV
authors.lastname: Parra
authors.affiliation: Grupo de Investigación GRICAFDE, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Fredy A
authors.initials: FA
authors.lastname: Patiño
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Luz M
authors.initials: LM
authors.lastname: Manjarrés
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Parra
authors.affiliation: Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Estrada
authors.affiliation: Grupo Vidarium, Centro de Investigación en Nutrición, Salud y Bienestar, Grupo Empresarial Nutresa.
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Agudelo
mesh_terms: D050154:Adiposity / Q000235:genetics; D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D000886:Anthropometry; D002154:Calpain / Q000235:genetics* / Q000502:physiology; D002648:Child; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004032:Diet; D004043:Dietary Fiber; D057140:Fast Foods / Q000009:adverse effects; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D007899:Leisure Activities; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics; D009043:Motor Activity; D009765:Obesity / Q000453:epidemiology / Q000235:genetics; D050177:Overweight / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics; D057185:Sedentary Behavior; D011795:Surveys and Questionnaires; D013690:Television; D000071247:Uncoupling Protein 3; D018910:Video Games
chemical_list: D004043:Dietary Fiber; D007473:Ion Channels; D024101:Mitochondrial Proteins; D011506:Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D002154:Calpain; C415197:calpain 10