title: Cobalt-catalyzed enantioselective directed C-H alkylation of indole with styrenes.
abstract: A cobalt-chiral phosphoramidite catalyst promotes enantioselective imine-directed C2-alkylation of Boc-protected indoles with styrenes. The reaction affords 1,1-diarylethane products in moderate to good yields with good enantioselectivities under mild conditions. A deuterium-labeling experiment suggests that the enantioselectivity is controlled by both the styrene insertion and the C-C reductive elimination steps.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
authors.forename: Pin-Sheng
authors.initials: PS
authors.lastname: Lee
authors.forename: Naohiko
authors.initials: N
authors.lastname: Yoshikai