title: Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the "risk" allele on clinical symptoms and facial affect recognition.
abstract: We studied AVPR1A RS3 polymorphism in schizophrenic patients and controls. AVPR1A RS3 was not associated with schizophrenia. The allele 327bp implicated in autism and social behavior was associated with negative symptoms and tended to be linked to patient facial affect recognition suggesting its impact on schizophrenia social phenotypes.
authors.affiliation: Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia. Electronic address: golimbet@mail.ru.
authors.forename: Vera
authors.initials: V
authors.lastname: Golimbet
authors.affiliation: Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.
authors.forename: Margarita
authors.initials: M
authors.lastname: Alfimova
authors.affiliation: Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.
authors.forename: Lilia
authors.initials: L
authors.lastname: Abramova
authors.affiliation: Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.
authors.forename: Vasily
authors.initials: V
authors.lastname: Kaleda
authors.affiliation: Department of Psychology, The Hebrew University of Jerusalem, Herzog Memorial Hospital, Givat Shaul, P.O. Box 3900, Jerusalem 91035, Israel.
authors.forename: Inga
authors.initials: I
authors.lastname: Gritsenko
mesh_terms: D000328:Adult; D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics* / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017483:Receptors, Vasopressin / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D012919:Social Behavior; D012938:Social Perception
chemical_list: C000599871:AVPR1A protein, human; D017483:Receptors, Vasopressin
keywords: AVPR1A; PANSS; Psychosis