title: Copper(ii)-catalyzed coupling reaction: an efficient and regioselective approach to N',N'-diaryl acylhydrazines.
abstract: Using N'-aryl acylhydrazines as aryl donors, a novel copper(ii)-catalyzed homo-coupling reaction of N'-aryl acylhydrazines has been developed for the synthesis of N',N'-diaryl acylhydrazines. We also provided a complementary procedure for the preparation of unsymmetrical diaryl acylhydrazines via cross-coupling reaction. These protocols featured mild reaction conditions, wide functional group tolerance and highly regioselective products. Control experiments indicated that this kind of coupling reaction might undergo a transient acyl diazene intermediate.
authors.affiliation: Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China. lugui@mail.sysu.edu.cn.
authors.forename: Ji-Quan
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Gong-Bin
authors.initials: GB
authors.lastname: Huang
authors.forename: Jiang
authors.initials: J
authors.lastname: Weng
authors.forename: Gui
authors.initials: G
authors.lastname: Lu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006834:Hydrazines; D003300:Copper