title: Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake.
abstract: Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
authors.affiliation: Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, P. R. China.
authors.forename: Jiashu
authors.initials: J
authors.lastname: Sun
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiuling
authors.initials: J
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.forename: Dingbin
authors.initials: D
authors.lastname: Liu
authors.forename: Qifang
authors.initials: Q
authors.lastname: Yin
authors.forename: Dongyan
authors.initials: D
authors.lastname: Xu
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wei
authors.forename: Baoquan
authors.initials: B
authors.lastname: Ding
authors.forename: Xinghua
authors.initials: X
authors.lastname: Shi
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D001692:Biological Transport; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry*; D055595:Mechanical Phenomena; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D008055:Lipids; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: biomedical applications; cellular uptake; core-shell nanoparticles; drug delivery; microfluidics