title: Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA.
abstract: The ability of mononucleating and dinucleating macrocylic polyamines and their novel nickel, copper and zinc complexes to induce the left-handed form of poly d(GC) was evaluated. The influence of the nuclearity, the presence or absence of metals ions, the linker length in the case of dinucleating ligands and the metal ion was determined. Almost all dinuclear metal complexes efficiently induced Z-DNA, the zinc ones being the least and the copper ones the most efficient ones. Additionally, the X-ray structures of three dinuclear metal complexes and one partially protonated ligand could be determined.
authors.affiliation: University of Zürich, Winterthurerstr. 190, CH 8057 Zürich, Switzerland. spingler@chem.uzh.ch.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Medina-Molner
authors.forename: Melanie
authors.initials: M
authors.lastname: Rohner
authors.forename: Devaraj
authors.initials: D
authors.lastname: Pandiarajan
authors.forename: Bernhard
authors.initials: B
authors.lastname: Spingler
mesh_terms: D002942:Circular Dichroism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D043542:DNA, Z-Form / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008968:Molecular Conformation; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D043542:DNA, Z-Form; D008024:Ligands; D003300:Copper; D015032:Zinc