title: Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin.
abstract: In order to improve curcumin's low water-solubility and selective delivery to cancer, we reported ligand-mediated micelles based on a Y-shaped biotin-poly (ethylene glycol)-poly (epsilon-caprolactone)2 (biotin-PEG-PCL2) copolymer. Its structure was characterized by (1)H NMR. The blank and drug-loaded micelles obtained by way of thin-film hydration were characterized by dynamic light scattering, X-ray diffraction, infrared spectroscopy and hemolytic test. Curcumin was loaded into micelles with a high encapsulating efficiency (93.83%). Curcumin's water-solubility was enhanced 170,400 times higher than free curcumin. Biotin-PEG-PCL2 micelles showed slower drug release in vitro than H2N-PEG-PCL2 micelles. In vitro cellular uptake and cytotoxicity tests showed that higher dosage of curcumin might overcome the effect of slow release on cytotoxicities because of its higher uptake induced by biotin, resulting in higher anticancer activities against MDA-MB-436 cells. In brief, Y-shaped biotin-PEG-PCL2 is a promising delivery carrier for anticancer drug.
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, No. 16866 East Road of Jingshi, Jinan 250200, Shandong Province, PR China; Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Jinan 250062, Shandong Province, PR China.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China.
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Song
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, No. 15 Datun Road, Chaoyang District, Beijing 100101, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Meng
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, No. 16866 East Road of Jingshi, Jinan 250200, Shandong Province, PR China; Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Jinan 250062, Shandong Province, PR China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Teng
authors.affiliation: Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China.
authors.forename: Fengying
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China. Electronic address: runliangfeng@126.com.
authors.forename: Runliang
authors.initials: R
authors.lastname: Feng
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001710:Biotin / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005026:Ethylene Glycols / Q000737:chemistry*; D005260:Female; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005026:Ethylene Glycols; D008823:Micelles; D011091:Polyesters; D011108:Polymers; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol); D001710:Biotin; D003474:Curcumin
keywords: Anticancer; Biotin; Copolymer; Curcumin; Poly (ethylene glyol)–poly (epsilon-caprolactone); Y-shaped