title: Epigenetic regulation of epithelial-mesenchymal transition by hypoxia in cancer: targets and therapy.
abstract: Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and its downstream transcriptional factors, is one of the most important mechanisms inducing epithelial-mesenchymal transition (EMT), which has been widely accepted as a crucial step to generate early stage of tumor metastasis. Accumulating evidence suggests that epigenetic mechanisms play important roles in hypoxia-induced EMT and metastasis. These epigenetic regulations are mediated by various players including chromatin modifiers, transcriptional co-regulators, microRNAs, etc. In this review, we discuss how his tone-modifying enzymes and transcriptional co-regulators regulate EMT under hypoxic conditions. Developed or potential anticancer agents targeting epigenetic molecules regulating hypoxia-induced EMT are also discussed.
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Wang
authors.affiliation: Research Center for Tumor Medical Science, Graduate Institute of Cancer Biology, China Medical University, Taichung 40402, Taiwan.
authors.forename: Kou-Juey
authors.initials: KJ
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D015687:Cell Hypoxia / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D018390:Gene Targeting / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents