title: Genetic association analysis for common variants in the Genetic Analysis Workshop 18 data: a Dirichlet regression approach.
abstract: We propose a genetic association analysis using Dirichlet regression to analyze the Genetic Analysis Workshop 18 data. Clinical variables, arranged in a longitudinal data structure, are employed to fit a multistate transition model in which the transition probabilities are served as a response in the proposed analysis. Furthermore, a gene-based association analysis via penalized regression is implemented using the markers at a single-nucleotide polymorphism level that we previously identified via nonpenalized Dirichlet regression.
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Ave., Toronto, ON, M5G 2M9, Canada ; Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Espin-Garcia
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Ave., Toronto, ON, M5G 2M9, Canada ; Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Ave., Toronto, ON, M5G 2M9, Canada.
authors.forename: Xin
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, ON, M5T 3L9, Canada.
authors.forename: Yonathan
authors.initials: Y
authors.lastname: Brhane
authors.affiliation: Ontario Cancer Institute/Princess Margaret Cancer Centre, 610 University Ave., Toronto, ON, M5G 2M9, Canada ; Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, ON M5T 3M7, Canada.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, Princess Margaret Cancer Centre, 610 University Ave., Toronto, ON, M5G 2M9, Canada ; Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, ON M5T 3M7, Canada.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu