title: Hybrid phenylthiazole and 1,3,5-triazine target cytosolic leucyl-tRNA synthetase for antifungal action as revealed by molecular docking studies.
abstract: BACKGROUND
  Leucyl-tRNA synthetase (LeuRS) is one of the essential enzymes belonging to the family of aminoacyl-tRNA synthetases (aaRSs), which executes the translation of genetic code by catalyzing the specific attachment of amino acids to their cognate tRNAs. This process is very crucial for survival of micro-organism and thus the inhibition of LeuRS offered a novel and lucrative target for developing new antimicrobials.
  
  
  RESULTS
  Docking studies using hybrid phenylthiazole-1,3,5-triazine derivatives revealed that these molecules acted as probable inhibitors of candida albicans cytosolic leucyl-tRNA synthetase.
  
  
  CONCLUSIONS
  The conjugates of phenylthiazole and 1,3,5-triazine can act as lead molecules towards the development of potential leucyl-tRNA synthetase inhibitors on the basis of molecular docking runs, which contribute to the possible mechanism of antifungal activity of these analogues.
authors.affiliation: Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Deemed University, Allahabad, 211007 India ; Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002 India ; Archimedes DoRa5 Visiting Fellow, Institute of Chemistry, Division of Bio-organic Chemistry, Institute of Chemistry, University of Tartu, Tartu, Estonia.
authors.forename: Udaya Pratap
authors.initials: UP
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Deemed University, Allahabad, 211007 India.
authors.forename: Hans Raj
authors.initials: HR
authors.lastname: Bhat
authors.affiliation: Faculty of Pharmacy, Uttarakhand Technical University, Deharadun, 248007 India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Gahtori
authors.affiliation: Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Deemed University, Allahabad, 211007 India ; Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002 India.
authors.forename: Ramendra K
authors.initials: RK
authors.lastname: Singh
keywords: 1,3,5-triazine; Docking; Leucyl-tRNA synthetase; phenylthiazole