title: Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: a preliminary report.
abstract: OBJECTIVE
  We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock.
  
  
  METHODS
  A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG).
  
  
  RESULTS
  Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%.
  
  
  CONCLUSIONS
  The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.
authors.affiliation: Emergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Shiga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirasawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishida
authors.forename: Shigeto
authors.initials: S
authors.lastname: Oda
authors.forename: Masataka
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Kenich
authors.initials: K
authors.lastname: Matsuda
authors.forename: Nobuya
authors.initials: N
authors.lastname: Kitamura
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Fuke
mesh_terms: D018806:APACHE; D000180:Acrylic Resins; D000181:Acrylonitrile / Q000031:analogs & derivatives; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D053208:Kaplan-Meier Estimate; D007773:Lactates / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D012772:Shock, Septic / Q000097:blood / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000180:Acrylic Resins; D002395:Catecholamines; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; D007773:Lactates; D008567:Membranes, Artificial; C016892:AN-69; D000181:Acrylonitrile