title: Adding to the STING.
abstract: STING (also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination of STING (MITA) by the ER-associated E3 ligase AMFR is essential for STING (MITA)-mediated signaling and innate antiviral response.
authors.affiliation: Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430072, China. Electronic address: shuh@whu.edu.cn.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address: wangyy@wh.iov.cn.
authors.forename: Yan-Yi
authors.initials: YY
authors.lastname: Wang
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D022423:Myeloid Cells / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D060285:Receptors, Autocrine Motility Factor / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D000099197:STING Protein
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases; C108626:INSIG1 protein, human; C532857:STING1 protein, human; D000099197:STING Protein; C555000:AMFR protein, human; C403191:TBK1 protein, human