title: Stem cell autograft and allograft in autoimmune diseases.
abstract: Autoimmune diseases are characterized by an insufficiency of immune tolerance and, although treated with a number of useful drugs, may need more unconventional therapeutic strategies for their more severe presentations. Among such unconventional therapeutic approaches, stem cell autograft and allograft have been used, with the aim of stimulating disease remission by modifying the pathogenic mechanisms that induce anomalous responses against self-antigens. Autologous transplantation is performed with the purpose of retuning autoimmune cells, whereas allogeneic transplantation is performed with the purpose of replacing anomalous immune effectors and mediators. In this article, we comprehensively review up-to-date information on the autoimmune diseases for which the transplantation of stem cells is indicated.
authors.affiliation: Division of Internal Medicine and Rheumatology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy. a.decata@operapadrepio.it.
authors.forename: Angelo
authors.initials: A
authors.lastname: De Cata
authors.affiliation: Division of Internal Medicine and Rheumatology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Matarangolo
authors.affiliation: Division of Internal Medicine and Rheumatology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Inglese
authors.affiliation: Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Rubino
authors.affiliation: Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy. g.mazzoccoli@operapadrepio.it.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli
mesh_terms: D064591:Allografts / Q000276:immunology*; D064592:Autografts / Q000276:immunology*; D001327:Autoimmune Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods
keywords: Allogeneic; Autoimmune disease; Autologous; Stem cell; Transplant