title: Predictive Value of Baseline Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS) Assessments for Identifying Risk of Prospective Reports of Suicidal Behavior During Research Participation.
abstract: OBJECTIVE
  Examine the ability of baseline electronic Columbia-Suicide Severity Rating Scale lifetime suicidal ideation and behavior categories to predict prospective reports of suicidal behavior in psychiatric and non-psychiatric research participants.
  
  
  METHODS
  Meta-analysis of 74,406 eC-SSRS assessments completed between September 2009 and December 2012.
  
  
  METHODS
  Thirty-three clinical research studies that used the electronic Columbia-Suicide Severity Rating Scale to assess suicidal ideation and behavior at baseline and prospectively during follow-up visits.
  
  
  METHODS
  Records from 6,760 patients with psychiatric disorders (opioid dependence, generalized anxiety, major depressive, and posttraumatic stress disorders) and 2,077 nonpsychiatric disorder patients (chronic obstructive pulmonary disease, epilepsy, fibromyalgia, human immunodeficiency virus, insomnia, multiple sclerosis, osteoarthritis, pain/back pain, Parkinson's disease, restless leg syndrome) were analyzed.
  
  
  METHODS
  Electronic Columbia-Suicide Severity Rating Scale assessment of lifetime suicidal ideation (5 severity levels) and suicidal behavior (4 types) at baseline and prospectively reported suicidal behavior during study participation.
  
  
  RESULTS
  Increasingly more severe lifetime suicidal ideation at baseline was associated with a progressively greater likelihood of prospectively reported suicidal behavior during study participation. Intent to act on suicidal ideation was most predictive of reports of suicidal behavior. Reports of lifetime suicidal behaviors at baseline also predicted subsequent suicidal behavior, and multiple lifetime behaviors monotonically increased prospective risk of suicidal behavior. Baseline suicidal ideation and behavior predicted future suicidal behavior in both psychiatric and non-psychiatric trials.
  
  
  CONCLUSIONS
  Lifetime reports of suicidal ideation and/or behavior at baseline significantly increased risk of prospectively reporting suicidal behavior during research trial participation in both psychiatric and nonpsychiatric patients. Lifetime prevalence of suicidal ideation and behavior is higher among psychiatric patients, but also presents a safety concern among nonpsychiatric patients when reported.
authors.affiliation: Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Dr. Mundt is with the Center for Telepsychology, Madison, Wisconsin; Dr. Gwaltney is with ERT in Philadelphia, Pennsylvania; Dr. Jefferson is Clinical Adjunct Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and Dr. Posner is with Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
authors.forename: John H
authors.initials: JH
authors.lastname: Greist
authors.affiliation: Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Dr. Mundt is with the Center for Telepsychology, Madison, Wisconsin; Dr. Gwaltney is with ERT in Philadelphia, Pennsylvania; Dr. Jefferson is Clinical Adjunct Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and Dr. Posner is with Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
authors.forename: James C
authors.initials: JC
authors.lastname: Mundt
authors.affiliation: Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Dr. Mundt is with the Center for Telepsychology, Madison, Wisconsin; Dr. Gwaltney is with ERT in Philadelphia, Pennsylvania; Dr. Jefferson is Clinical Adjunct Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and Dr. Posner is with Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Gwaltney
authors.affiliation: Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Dr. Mundt is with the Center for Telepsychology, Madison, Wisconsin; Dr. Gwaltney is with ERT in Philadelphia, Pennsylvania; Dr. Jefferson is Clinical Adjunct Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and Dr. Posner is with Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
authors.forename: James W
authors.initials: JW
authors.lastname: Jefferson
authors.affiliation: Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Dr. Mundt is with the Center for Telepsychology, Madison, Wisconsin; Dr. Gwaltney is with ERT in Philadelphia, Pennsylvania; Dr. Jefferson is Clinical Adjunct Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and Dr. Posner is with Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York.
authors.forename: Kelly
authors.initials: K
authors.lastname: Posner
keywords: eC-SSRS; electronic patient-reported outcomes; prospective risk; suicide risk assessment