title: Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis.
abstract: Growth factors and their downstream receptor tyrosine kinases (RTKs) mediate a number of biological processes controlling cell function. Adaptor (docking) proteins, which consist exclusively of domains and motifs that mediate molecular interactions, link receptor activation to downstream effectors. Recent studies have revealed that Grb2-associated-binders (Gab) family members (including Gab1, Gab2, and Gab3), when phosphorylated on tyrosine residues, provide binding sites for multiple effector proteins, such as Src homology-2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) and phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, thereby playing important roles in transducing RTKs-mediated signals into pathways with diversified biological functions. Here, we provide an up-to-date overview on the domain structure and biological functions of Gab1, the most intensively studied Gab family protein, in growth factor signaling and biological functions, with a special focus on angiogenesis.
authors.affiliation: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
authors.forename: Weiye
authors.initials: W
authors.lastname: Wang
authors.affiliation: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
authors.forename: Suowen
authors.initials: S
authors.lastname: Xu
authors.affiliation: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
authors.forename: Meimei
authors.initials: M
authors.lastname: Yin
authors.affiliation: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA. Electronic address: zheng-gen_jin@urmc.rochester.edu.
authors.forename: Zheng Gen
authors.initials: ZG
authors.lastname: Jin
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010766:Phosphorylation / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C098587:GAB1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases
keywords: Angiogenesis; Endothelial cells; Gab1; Receptor tyrosine kinase; Tyrosine phosphorylation