title: Micro-invasive suture trabeculotomy after canaloplasty: preliminary results.
abstract: BACKGROUND
  In this study, a conjunctival-sparing ab interno approach for circumferential trabeculotomy, termed micro-invasive suture trabeculotomy (MIST) and its preliminary results are presented.
  
  
  METHODS
  Retrospective case-series in a university setting.
  
  
  METHODS
  A total of 31 patients with open-angle glaucoma with history of canaloplasty.
  
  
  METHODS
  A conjunctival-sparing ab interno approach for circumferential trabeculotomy, termed MIST.
  
  
  METHODS
  Mean decrease of intraocular pressure (IOP) and number of pressure-lowering medications.
  
  
  RESULTS
  Mean decrease of IOP was 11.1 mmHg (standard deviation [SD], 9.9 mmHg) at 6 months, 12.1 mmHg (SD, 10.5 mmHg) at 12 months and 13.5 mmHg (SD, 11.4 mmHg) at 24 months. The average percent lowering of IOP was 36.7% (SD, 32.8%) at 6 months, 41.4% (SD, 35.9%) at 12 months and 44.6% (SD, 37.7%) at 24 months. The number of pressure-lowering medications decreased by 1.1 (SD, 1.3) at month 6, by 1.2 (SD, 1.5) at month 12, and by 1.3 (SD, 1.6) at month 24.
  
  
  CONCLUSIONS
  MIST is a promising approach for the treatment of open-angle glaucoma, which is insufficiently controlled with canaloplasty. The procedure achieved significant and sustained lowering of the intraocular pressure and demonstrated an excellent safety profile. The main advantages of the procedure are: easy to learn, fast to perform, and sparing of the conjunctiva for further filtration surgery, if necessary.
authors.affiliation: Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Bogomil
authors.initials: B
authors.lastname: Voykov
authors.affiliation: Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.|Department of Ophthalmology, Vitreoretinal Diseases, Knappschaft Eye Hospital, Sulzbach, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Szurman
authors.affiliation: Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Spyridon
authors.initials: S
authors.lastname: Dimopoulos
authors.affiliation: Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Focke
authors.initials: F
authors.lastname: Ziemssen
authors.affiliation: Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Omar
authors.initials: O
authors.lastname: Alnahrawy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D016850:Limbus Corneae / Q000601:surgery; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013536:Suture Techniques; D014130:Trabeculectomy / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents
keywords: glaucoma; glaucoma incisional surgery; new treatments