title: Silver-Mediated Synthesis of Indolizines via Oxidative C-H functionalization and5- endo-digcyclization.
abstract: An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and5-endo-digcyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance and selectivity. The structure of the product was confirmed by the X-ray crystallographic studies. The Ag2CO3required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.
authors.affiliation: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
authors.forename: Amit N
authors.initials: AN
authors.lastname: Pandya
authors.affiliation: Department of Chemistry, Creighton University, Omaha, NE 68178, USA Tel: (402) 280 2938;
authors.forename: James T
authors.initials: JT
authors.lastname: Fletcher
authors.affiliation: Department of Chemistry, Creighton University, Omaha, NE 68178, USA Tel: (402) 280 2938;
authors.forename: Eric M
authors.initials: EM
authors.lastname: Villa
authors.affiliation: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA ; Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Agrawal
keywords: 5-endo-dig cyclization; C-H functionalization; Indolizine