title: A free-blockage controlled release system based on the hydrophobic/hydrophilic conversion of mesoporous silica nanopores.
abstract: A pH-responsive free-blockage release system was achieved through controlling the hydrophobic/hydrophilic conversion of mesoporous silica nanopores. This system further presented pulsatile release with changing pH values between 4.0 and 7.0 for several cycles. This free-blockage release system could also release antitumor agents to induce cell death after infecting tumor cells and could have the ability of continuous infection to tumor cells with high drug-delivery efficiency and few side effects.
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China).
authors.forename: Wenqian
authors.initials: W
authors.lastname: Wang
authors.forename: Linfeng
authors.initials: L
authors.lastname: Chen
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Hongwu
authors.initials: H
authors.lastname: Du
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Song
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D015251:Epirubicin / Q000737:chemistry / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry; D058608:Nanopores; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D015251:Epirubicin; D012822:Silicon Dioxide
keywords: controlled release; drug delivery; hydrophobic/hydrophilic effects; mesoporous materials; silica