title: RNA recognition and stress granule formation by TIA proteins.
abstract: Stress granule (SG) formation is a primary mechanism through which gene expression is rapidly modulated when the eukaryotic cell undergoes cellular stresses (including heat, oxidative, viral infection, starvation). In particular, the sequestration of specifically targeted translationally stalled mRNAs into SGs limits the expression of a subset of genes, but allows the expression of heatshock proteins that have a protective effect in the cell. The importance of SGs is seen in several disease states in which SG function is disrupted. Fundamental to SG formation are the T cell restricted intracellular antigen (TIA) proteins (TIA-1 and TIA-1 related protein (TIAR)), that both directly bind to target RNA and self-associate to seed the formation of SGs. Here a summary is provided of the current understanding of the way in which TIA proteins target specific mRNA, and how TIA self-association is triggered under conditions of cellular stress.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. saboora.waris@monash.edu.
authors.forename: Saboora
authors.initials: S
authors.lastname: Waris
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. matthew.wilce@monash.edu.
authors.forename: Matthew Charles James
authors.initials: MC
authors.lastname: Wilce
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. jackie.wilce@monash.edu.
authors.forename: Jacqueline Anne
authors.initials: JA
authors.lastname: Wilce
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012313:RNA