title: Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis.
abstract: BACKGROUND
  Epidemiological studies have suggested that variants on adiponectin (ADIPOQ) and its receptor ADIPOR1 (adiponectin receptor 1) are associated with colorectal cancer (CRC) risk; however, the results were inconclusive. The aim of the study was to evaluate the associations between the variants on ADIPOQ and ADIPOR1 and the CRC risk with a hospital-based case-control study in the Chinese population along with meta-analysis of available epidemiological studies.
  
  
  METHODS
  With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated. Meta-analysis of the published epidemiological studies was performed to investigate the associations between the variants and CRC risk.
  
  
  RESULTS
  For the population study, we found that variant rs1342387 of ADIPOR1 was associated with a reduced risk for CRC [adjusted odds ratio (OR) = 0.74, 95% confidential intervals (95% CI) = 0.57-0.97; CT/TT vs. CC]. The meta-analysis also suggested a significant association for rs1342387 and CRC risk; the pooled OR was 0.79 (95% CI = 0.66-0.95) for the CT/TT carriers compared to CC homozygotes under the random-effects model (Q = 8.06, df = 4, P = 0.089; I(2) = 50.4%). The case-control study found no significant association for variants rs266729, rs822395, rs2241766, and rs1501299 on ADIPOQ or variant rs12733285 on ADIPOR1 and CRC susceptibility, which were consistent with results from the meta-analysis studies.
  
  
  CONCLUSIONS
  These data suggested that variant rs1342387 on ADIPOR1 may be a novel CRC susceptibility factor.
authors.affiliation: Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, P. R China. ouyiyi@sohu.com.|Medical Department, The General Hospital of Navy, Beijing, 100037, P. R China. ouyiyi@sohu.com.
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Ou
authors.affiliation: Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, P. R China. pzchen@sibs.ac.cn.
authors.forename: Peizhan
authors.initials: P
authors.lastname: Chen
authors.affiliation: Toxicology Institute, Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, College of Preventive Medicine; Third Military Medical University, Chongqing, 400038, P. R. China. ziyuanzhou@yahoo.com.|Department of Environment Health, College of Preventive Medicine; Third Military Medical University, Chongqing, 400038, P. R. China. ziyuanzhou@yahoo.com.
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, P. R China. clli01@sibs.ac.cn.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Li
authors.affiliation: Toxicology Institute, Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, College of Preventive Medicine; Third Military Medical University, Chongqing, 400038, P. R. China. jinyiliutmmu@163.com.
authors.forename: Jinyi
authors.initials: J
authors.lastname: Liu
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. ktajima@aichi-cc.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.affiliation: Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China. guojs@shhyy.com.
authors.forename: Junsheng
authors.initials: J
authors.lastname: Guo
authors.affiliation: Toxicology Institute, Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, College of Preventive Medicine; Third Military Medical University, Chongqing, 400038, P. R. China. caojia@mail.tmmu.com.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Cao
authors.affiliation: Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, P. R China. huiwang@sibs.ac.cn.|Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, 100021, P. R. China. huiwang@sibs.ac.cn.|School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, P. R. China. huiwang@sibs.ac.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin