title: Stimulation of phosphorylation of ERK and CREB by phellopterin and auraptene isolated from Citrusjunos.
abstract: Bioactive compounds from citrus fruits contribute many benefits to human health. Extracellular signal-regulated kinase (ERK) signaling plays an important role in the regulation of multiple cellular processes. Activation of the ERK-cAMP response element binding protein (CREB) signaling is required for long- term memory formation. In this study, auraptene, phellopterin, thymol, coniferyl alcohol 9-methyl ether and methyl ferulate were isolated from Citrus junos. Among the five compounds isolated, auraptene and phellopterin increased the phosphorylation of ERK and CREB. This study provides, to our knowledge, the first evidence that phellopterin potently stimulates the phosphorylation of ERK and CREB. Phellopterin could be a novel neuroprotective agent.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Mai
authors.initials: M
authors.lastname: Takagi
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Tamura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Masuda
mesh_terms: D002109:Caffeic Acids / Q000494:pharmacology; D045744:Cell Line, Tumor; D002957:Citrus / Q000737:chemistry; D003374:Coumarins / Q000494:pharmacology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation / Q000187:drug effects*; D013943:Thymol / Q000494:pharmacology
chemical_list: D002109:Caffeic Acids; D003374:Coumarins; D017362:Cyclic AMP Response Element-Binding Protein; C104601:phellopterin; D013943:Thymol; D048049:Extracellular Signal-Regulated MAP Kinases; C105832:aurapten; C530806:methyl ferulate