title: 30-y follow-up of a Pu/Am inhalation case.
abstract: In 1983, a young man inhaled accidentally a large amount of plutonium and americium. This case was carefully followed until 2013. Since no decorporation measures had been taken, the undisturbed metabolism of Pu and Am can be derived from the data. First objective was to determine the amount of inhaled radionuclides and to estimate committed effective dose. In vivo and excretion measurements started immediately after the inhalation, and for quality assurance, all types of measurements were performed by different labs in Europe and the USA. After dose assessment by various international groups were completed, the measurements were continued to produce scientific data for model validation. The data have been analysed here to estimate lung absorption parameter values for the inhaled plutonium and americium oxide using the proposed new ICRP Human Respiratory Tract Model. As supplement to the biokinetic modelling, biological data from three different cytogenetic markers have been added. The estimated committed effective dose is in the order of 1 Sv. The subject is 30 y after the inhalation, of good health, according to a recent medical check-up.
authors.affiliation: Paul Scherrer Institute (PSI), Villigen, Switzerland christian.wernli@alumni.ethz.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Wernli
authors.affiliation: Paul Scherrer Institute (PSI), Villigen, Switzerland.
authors.forename: Jost
authors.initials: J
authors.lastname: Eikenberg
authors.affiliation: Karlsruhe Institute for Technology (KIT), Karlsruhe, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Marzocchi
authors.affiliation: Karlsruhe Institute for Technology (KIT), Karlsruhe, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Breustedt
authors.affiliation: Federal Office for Radiation Protection (BfS), Oberschleissheim, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Oestreicher
authors.affiliation: Federal Office for Radiation Protection (BfS), Oberschleissheim, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Romm
authors.affiliation: Public Health England (PHE), Harwell Science and Innovation Campus, UK.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Gregoratto
authors.affiliation: Public Health England (PHE), Harwell Science and Innovation Campus, UK.
authors.forename: James
authors.initials: J
authors.lastname: Marsh
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics*; D000576:Americium / Q000493:pharmacokinetics*; D001822:Body Burden; D003198:Computer Simulation; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008954:Models, Biological; D011005:Plutonium / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D014915:Whole-Body Counting / Q000379:methods*
chemical_list: D000396:Air Pollutants, Radioactive; D011005:Plutonium; D000576:Americium