title: Contribution of Crk adaptor proteins to host cell and bacteria interactions.
abstract: The Crk adaptor family of proteins comprises the alternatively spliced CrkI and CrkII isoforms, as well as the paralog Crk-like (CrkL) protein, which is encoded by a different gene. Initially thought to be involved in signaling during apoptosis and cell adhesion, this ubiquitously expressed family of proteins is now known to play essential roles in integrating signals from a wide range of stimuli. In this review, we describe the structure and function of the different Crk proteins. We then focus on the emerging roles of Crk adaptors during Enterobacteriaceae pathogenesis, with special emphasis on the important human pathogens Salmonella, Shigella, Yersinia, and enteropathogenic Escherichia coli. Throughout, we remark on opportunities for future research into this intriguing family of proteins.
authors.affiliation: Department of Microbiology, Medical School, Complutense University of Madrid, Avenida de la Complutense sn, 28040 Madrid, Spain.
authors.forename: Narcisa
authors.identifier: 0000-0002-0366-6591
authors.initials: N
authors.lastname: Martinez-Quiles
authors.affiliation: Kansas State University, 1600 Denison Avenue, Manhattan, KS 66506, USA.
authors.forename: Leigh Ann
authors.initials: LA
authors.lastname: Feuerbacher
authors.affiliation: Department of Microbiology, Medical School, Complutense University of Madrid, Avenida de la Complutense sn, 28040 Madrid, Spain.
authors.forename: María
authors.identifier: 0000-0003-2897-0474
authors.initials: M
authors.lastname: Benito-León
authors.affiliation: Kansas State University, 1600 Denison Avenue, Manhattan, KS 66506, USA.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Hardwidge
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D002448:Cell Adhesion / Q000235:genetics*; D054308:Enteropathogenic Escherichia coli / Q000235:genetics; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D010766:Phosphorylation; D020033:Protein Isoforms / Q000235:genetics; D050737:Proto-Oncogene Proteins c-crk / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: C485285:CRK protein, human; D020033:Protein Isoforms; D050737:Proto-Oncogene Proteins c-crk