title: Altered intrinsic connectivity networks in frontal lobe epilepsy: a resting-state fMRI study.
abstract: Examining the resting-state networks (RSNs) may help us to understand the neural mechanism of the frontal lobe epilepsy (FLE). Resting-state functional MRI (fMRI) data were acquired from 46 patients with FLE (study group) and 46 age- and gender-matched healthy subjects (control group). The independent component analysis (ICA) method was used to identify RSNs from each group. Compared with the healthy subjects, decreased functional connectivity was observed in all the networks; however, in some areas of RSNs, functional connectivity was increased in patients with FLE. The duration of epilepsy and the seizure frequency were used to analyze correlation with the regions of interest (ROIs) in the nine RSNs to determine their influence on FLE. The functional network connectivity (FNC) was used to study the impact on the disturbance and reorganization of FLE. The results of this study may offer new insight into the neuropathophysiological mechanisms of FLE.
authors.affiliation: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Xinzhi
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Radiotherapy, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Junshu
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D019295:Computational Biology / Q000379:methods; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net; D009434:Neural Pathways / Q000502:physiology; D012984:Software; D055815:Young Adult