title: Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability.
abstract: The aim of this work was to compare and contrast the mechanical properties and physical stabilities of oral films prepared with either thermal ink-jet printing (TIJP) or solvent casting (SC). Clonidine hydrochloride was selected as a model drug because of its low therapeutic dose and films were prepared using cellulose polymers. Mechanical testing showed that the printed films had Young's moduli and tensile strength values similar to the free film, while casted films were significantly more brittle. The drug also appeared to crystallize out of casted films during stress testing whereas printed films remained unchanged. The dissolution behavior of printed and cast films were similar, because of the rapid disintegration of the polymer. The conclusion is that printing resulted in a better film than casting because the drug resided on the film, rather than in the film where it could exert a plasticizing effect.
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Asma B M
authors.initials: ABM
authors.lastname: Buanz
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Belaunde
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Nina
authors.initials: N
authors.lastname: Soutari
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuleu
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Mine Orlu
authors.initials: MO
authors.lastname: Gul
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address: s.gaisford@ucl.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Gaisford
mesh_terms: D000284:Administration, Oral; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D003000:Clonidine / Q000008:administration & dosage; D003199:Computer Systems; D003460:Crystallization; D016503:Drug Delivery Systems / Q000295:instrumentation*; D065546:Drug Liberation; D004355:Drug Stability; D006801:Humans; D011142:Polyvinyl Alcohol / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation*; D013718:Tensile Strength
chemical_list: D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium; D003000:Clonidine
keywords: Clonidine; Critical humidity; Dynamic mechanical analysis; Oral films; Thermal ink-jet printing