title: mTORC1 gRABs the Golgi.
abstract: A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Sanchez-Gurmaches
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address: david.guertin@umassmed.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Guertin
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D020761:rab1 GTP-Binding Proteins / Q000502:physiology*
chemical_list: D020761:rab1 GTP-Binding Proteins