title: Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14.
abstract: We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses.
authors.forename: Margaret
authors.initials: M
authors.lastname: Okomo-Adhiambo
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Fry
authors.forename: Su
authors.initials: S
authors.lastname: Su
authors.forename: Ha T
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Anwar Abd
authors.initials: AA
authors.lastname: Elal
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Negron
authors.forename: Julie
authors.initials: J
authors.lastname: Hand
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Garten
authors.forename: John
authors.initials: J
authors.lastname: Barnes
authors.forename: Xu
authors.initials: X
authors.lastname: Xiyan
authors.forename: Julie M
authors.initials: JM
authors.lastname: Villanueva
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Gubareva
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000494:pharmacology*; D010802:Phylogeny; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D053139:Oseltamivir; D009439:Neuraminidase