title: TT genotype of GNAS1 T393C polymorphism predicts better outcome of advanced non-small cell lung cancer patients.
abstract: OBJECTIVE
  To evaluate the potential prognostic value of GNAS1 T393C polymorphism in advanced non-small cell lung cancer.
  
  
  METHODS
  We extracted genomic DNA from the peripheral blood leucocytes of 94 patients with advanced non-small cell lung cancer. Quantitative real-time polymerase chain reaction was used to determine the allelic discrimination. The correlation between genotype and overall survival was evaluated using the multivariate analysis and Kaplan-Meier approach.
  
  
  RESULTS
  Thirty-eight out of 94 (40%) patients displayed a TT genotype, 29 out of 94 (31%) a CT genotype and 27 out of 94 (29%) a CC genotype. The median survival of TT (25 mo) genotype carriers was longer than CT (12 mo) or CC (8 mo) genotype carriers. The favorable TT genotype predicted better overall survival (OS) (2-year OS: 48%; P =0.01) compared with CT (2-year OS: 18%) or CC (2-year OS: 15%) genotype. However, dichotomization between C-genotypes (CC + CT) and T-genotypes (TT) revealed signiﬁcantly lower survival rates (2-year OS: 16%; P = 0.01) for C allele carriers.
  
  
  CONCLUSIONS
  Our data provided strong evidence that the GNAS1 T393C genetic polymorphism inﬂuenced the prognosis in advanced non-small lung cancer with a worse outcome for C allele carriers.
authors.affiliation: Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Gong
authors.affiliation: Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Hu
authors.affiliation: Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
authors.forename: Xiu-Ling
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
authors.forename: Qin-Bin
authors.initials: QB
authors.lastname: Song
keywords: Advanced non-small cell lung cancer; GNAS1; Polymorphism; Prognosis