title: A DNA-inspired synthetic ion channel based on G-C base pairing.
abstract: A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a modular one-pot azide-alkyne cycloaddition. Single channel analysis showed that this dinucleoside predominantly forms large channels with 2.9 nS conductance for the transport of potassium ions across a phospholipid bilayer. Transmission electron microscopy, atomic force microscopy, and circular dichroism spectroscopy studies reveal that this dinucleoside can spontaneously associate through Watson-Crick canonical H-bonding and π-π stacking to form stable supramolecular nanostructures. Most importantly, the ion channel activity of this G-C dinucleoside can be inhibited using the nucleobase cytosine.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata, West Bengal 700032, India.
authors.forename: Rabindra Nath
authors.initials: RN
authors.lastname: Das
authors.forename: Y Pavan
authors.initials: YP
authors.lastname: Kumar
authors.forename: Ole Mathis
authors.initials: OM
authors.lastname: Schütte
authors.forename: Claudia
authors.initials: C
authors.lastname: Steinem
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Dash
mesh_terms: D020029:Base Pairing; D003562:Cytidine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006151:Guanosine / Q000737:chemistry*; D006860:Hydrogen Bonding; D007473:Ion Channels / Q000737:chemistry*; D011789:Quantum Theory
chemical_list: D007473:Ion Channels; D006151:Guanosine; D003562:Cytidine; D004247:DNA