title: Sickle cell disease clinical phenotypes in children from South-Western, Nigeria.
abstract: BACKGROUND
  The clinical phenotypes of children with sickle cell disease (SCD) are poorly described in many sub-Saharan countries including Nigeria.
  
  
  OBJECTIVE
  The objective was to highlight various clinical phenotypes of SCD in children and investigate the influence of sociodemographic indices on the development of SCD complications.
  
  
  METHODS
  We carried out a cross-sectional study of 240 pediatric patients attending the sickle cell clinic and the emergency room in a teaching hospital in South-Western Nigeria over a 12-month period. The clinical phenotypes and severity of the disease were documented, and the influence of sociodemographic variables was investigated.
  
  
  RESULTS
  The five leading clinical phenotypes in our patients were significant pain episodes, that is, vaso-occlusive crisis in 159 (66.3%); anemic crisis in 62 (25.8%); severe bacterial infections, 57 (23.8%); acute chest syndrome (ACS), 27 (11.3%) and stroke, 7 (2.9%). Forty-two (33.1%) had a previous history of dactylitis (hand-foot syndrome). Other clinical phenotypes such as avascular necrosis of the femur, 4 (1.7%); nephropathy, 2 (0.8%); priapism, gallstone and chronic leg ulcer, one (0.4%) each, were not commonly seen. More children with a history of asthma had ACS. Furthermore, high steady-state white blood cell count was associated with severe disease.
  
  
  CONCLUSIONS
  The clinical phenotypes of SCD in children from South-Western Nigeria are highly variable with the disease manifesting very early and about 10% having significant complications. Sociodemographic characteristics appear to have little influence on the development of SCD complications among our patients, but age and low-socioeconomic class are associated with anemic crisis.
authors.affiliation: Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile Ife, Nigeria, .
authors.forename: S A
authors.initials: SA
authors.lastname: Adegoke
authors.forename: O O
authors.initials: OO
authors.lastname: Adeodu
authors.forename: A D
authors.initials: AD
authors.lastname: Adekile
mesh_terms: D056586:Acute Chest Syndrome / Q000209:etiology*; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D000986:Antisickling Agents / Q000627:therapeutic use; D001249:Asthma / Q000453:epidemiology; D001424:Bacterial Infections / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology; D006529:Hepatomegaly / Q000209:etiology*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007223:Infant; D008288:Malaria / Q000453:epidemiology; D008297:Male; D009549:Nigeria; D010146:Pain / Q000209:etiology*; D010641:Phenotype; D012720:Severity of Illness Index; D013163:Splenomegaly / Q000209:etiology*; D020521:Stroke / Q000209:etiology*
chemical_list: D000986:Antisickling Agents; D006918:Hydroxyurea