title: Effect of the aqueous extract of Senecio biafrae (Oliv. & Hiern) J. Moore on some fertility parameters in immature female rat.
abstract: BACKGROUND
  Senecio biafrae is a plant from the huge family of Asteraceae used in the African pharmacopoeia for the treatment of many ailments among which is infertility.
  
  
  METHODS
  The aqueous extract, which was primarily subjected to polyphenol analysis, has been administered to immature female rats for 20 days at 8, 32, 64 and 128 mg/kg of body weight. The day following the treatment, the animals were sacrificed; their serum, ovary and uterus were retained respectively for reproductive hormones, ovarian and uterine proteins, and ovarian cholesterol assays.
  
  
  RESULTS
  Light body weight gain variation of treated animals was observed during the experimental period. A significant increase (p ˂ 0.05) in serum estradiol and proteins as well as in uterine weight (p ˂ 0.01) of all Senecio biafrae treated animals was noted. No significant variation was noticed in the ovarian weight and follicle numbers.
  
  
  CONCLUSIONS
  The various biochemical and physiological parameters of fertility were significantly improved with the aqueous extract of Senecio biafrae, thus attesting some of its traditional usage.
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: L L
authors.initials: LL
authors.lastname: Lienou
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon. Electronic address: bphelix@yahoo.co.uk.
authors.forename: P B
authors.initials: PB
authors.lastname: Telefo
authors.affiliation: University of Yaounde I: Analytical Chemistry Laboratory Inorganic Chemistry Department, Faculty of Sciences, P.O Box 812, Yaounde, Cameroon.
authors.forename: J R
authors.initials: JR
authors.lastname: Njimou
authors.affiliation: Pathological Analysis Department of the Central Hospital of Yaounde, Cameroon.
authors.forename: C
authors.initials: C
authors.lastname: Nangue
authors.affiliation: University of Ouagadougou, UFR/SVT, Laboratory of Animal Physiology, 03P.O. Box 7021 Ouagadougou 03, Burkina Faso.
authors.forename: B R
authors.initials: BR
authors.lastname: Bayala
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: S C
authors.initials: SC
authors.lastname: Goka
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: P
authors.initials: P
authors.lastname: Biapa
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: M D
authors.initials: MD
authors.lastname: Yemele
authors.affiliation: State University of Céara, Faculty of Veterinary Sciences, LAMOFOPA, Fortaleza, Brazil.
authors.forename: N J
authors.initials: NJ
authors.lastname: Donfack
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: J T
authors.initials: JT
authors.lastname: Mbemya
authors.affiliation: University of Dschang, Faculty of Science, Department of Biochemistry, P.O Box: 67 Dschang, Cameroon.
authors.forename: S R
authors.initials: SR
authors.lastname: Tagne
authors.affiliation: State University of Céara, Faculty of Veterinary Sciences, LAMOFOPA, Fortaleza, Brazil.
authors.forename: A P R
authors.initials: AP
authors.lastname: Rodrigues
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D017208:Rats, Wistar; D012674:Senecio; D012741:Sexual Maturation / Q000187:drug effects; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D010636:Phenols; D010936:Plant Extracts; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Apigenin CID 5280443; Aqueous extract; Caffeic acid CID 689043; Catechin CID 9064; Eugenol CID 3314; Fertility; Hydroxy-tyrosol CID 216200; Ovary; Phenol CID 996; Quercetin CID 5280343; Rutin CID 5280805; Senecio biafrae; Theobromine CID 5429; Uterus