title: [Research advances in immunological dysfunction in children with autism spectrum disorders].
abstract: Autism spectrum disorders (ASD) are a group of neuro-developmental disorders in early childhood which are defined by social difficulties, communication deficits and repetitive or restrictive interests and behaviours. The etiology of ASD remains poorly understood. Much research has shown that children with ASD suffer from immunological dysfunction. This article reviews the current research progress on immunological dysfunction in children with ASD, including abnormalities in immune cells, antibodies, complements, cytokines, major histocompatibility complex and their potential association with ASD, and explores the impacts of maternal immunological activation on the immune dysfunction of children with ASD.
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun 130021, China. jidawangtiantian@163.com.
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: DU
authors.forename: Ling
authors.initials: L
authors.lastname: Shan
authors.forename: Fei-Yong
authors.initials: FY
authors.lastname: Jia
mesh_terms: D001323:Autoantibodies / Q000097:blood; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000209:etiology / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008214:Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D007136:Immunoglobulins