title: High reproducibility of adenosine stress cardiac MR myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy.
abstract: OBJECTIVE
  To evaluate the reproducibility of first-pass contrast-enhanced cardiac MR (CMR) myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy (NIDCM).
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Single centre, tertiary care hospital.
  
  
  METHODS
  6 outpatient participants with NIDCM.
  
  
  RESULTS
  Reproducibility of semiquantitative myocardial perfusion analysis by CMR.
  
  
  METHODS
  6 patients with NIDCM were studied twice using first-pass of contrast transit through the left ventricular (LV) myocardium with a saturation-recovery gradient echo sequence at rest and during adenosine-induced hyperaemia. The anterior wall was divided into endocardial (Endo) and epicardial (Epi) segments. The Myocardial Perfusion Index (MPI) was calculated as the myocardial signal augmentation rate normalised to the LV cavity rate. The Myocardial Perfusion Reserve Index (MPRI) was calculated as hyperaemic/resting MPI.
  
  
  RESULTS
  Between study 1 and 2, median MPI was similar for resting Endo (0.076 vs 0.077), hyperaemic Endo (0.143 vs 0.143), resting Epi (0.073 vs 0.074), and hyperaemic Epi (0.135 vs 0.134). Median MPRI was similar for Endo (1.84 vs 1.87) and Epi (1.90 vs 2.00). Combining Endo and Epi MPI (N=12), there was excellent agreement between Study 1 and 2 for resting MPI (r=0.998, intraclass correlation coefficient (ICC) 0.998, coefficients of variation (CoV) 1.4%), hyperaemic MPI (r=0.979, ICC 0.963, CoV 3.3%) and MPRI (r=0.989, ICC 0.94, CoV 3.8%).
  
  
  CONCLUSIONS
  Resting and hyperaemic myocardial perfusion using a normalised upslope analysis during adenosine CMR is a highly reproducible technique in patients with NIDCM.
  
  
  BACKGROUND
  Clinical Trials.Gov ID NCT00574119.
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lawson
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Susan P
authors.initials: SP
authors.lastname: Bell
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Adkisson
authors.affiliation: Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Cardiology Section, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Ooi
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Sawyer
authors.affiliation: Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Cardiology Section, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
authors.forename: Marvin W
authors.initials: MW
authors.lastname: Kronenberg
mesh_terms: D000241:Adenosine; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011446:Prospective Studies; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D000241:Adenosine