title: Studying classical swine fever virus: making the best of a bad virus.
abstract: Classical swine fever (CSF) is a highly contagious and often fatal disease that affects domestic pigs and wild boars. Outbreak of CSF can cause heavy economic losses to the pig industry. The strategies to prevent, control and eradicate CSF disease are based on containing the disease through a systematic prophylactic vaccination policy and a non-vaccination stamping-out policy. The quest for prevention, control and eradication of CSF has moved research forward in academia and industry, and has produced noticeable advances in understanding fundamental aspects of the virus replication mechanisms, virulence, and led to the development of new vaccines. In this review we summarize recent progress in CSFV epidemiology, molecular features of the genome and proteome, the molecular basis of virulence, and the development of anti-virus technologies.
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China. Electronic address: jiwei_yunlong@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.affiliation: Department of Computer and Information Science, Fordham University, Bronx, NY 10458, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Nai-Zheng
authors.initials: NZ
authors.lastname: Ding
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China. Electronic address: hchqiang@126.com.
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: He
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D035843:Biomedical Research / Q000639:trends; D006691:Classical Swine Fever / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D006692:Classical Swine Fever Virus / Q000235:genetics* / Q000276:immunology / Q000502:physiology*; D054884:Host-Pathogen Interactions; D034421:Sus scrofa; D013552:Swine; D014765:Viral Vaccines / Q000276:immunology / Q000302:isolation & purification; D014774:Virulence; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines
keywords: CSFV life cycle; Classical swine fever virus; Epidemiology; Protein functions; Reverse genetics; Virulence