title: Thromboembolic Events in Malignant Pleural Mesothelioma.
abstract: OBJECTIVE
  Malignant pleural mesothelioma (MPM) increases the risk of thromboembolic events (TEEs). In this retrospective study, we aimed to determine the rate of TEEs in MPM and investigate its relationship with the presence of thrombocytosis, the disease stage, and the tumor histopathology.
  
  
  METHODS
  The study included 178 patients who were histopathologically diagnosed as MPM between the years January 2008 and June 2014.
  
  
  RESULTS
  The mean age was 58.7 ± 11.8 years, and the median follow-up time was 8 months. Seventy-one patients (39.9%) had thrombocytosis (>350 × 10(3)/mL). In total, 14 (7.9%) TEEs were identified: 6 (3.4%) pulmonary thromboembolism, 6 (3.4%) deep venous thrombosis, and 2 (1.1%) myocardial infarctions. Although 5 (2.8%) of the TEEs preceded the diagnosis of MPM, 1 (0.6%) occurred simultaneously with the diagnosis of MPM and 8 (4.5%) followed the diagnosis of MPM. Thromboembolic event rates were not statistically different based on the presence of thrombocytosis (P = .51), disease stage (P = .14), and histopathology (P = .38).
  
  
  CONCLUSIONS
  The rate of TEEs was 7.9%. Presence of thrombocytosis, disease stage, and histopathology did not affect the incidence of TEEs.
authors.affiliation: Department of Chest Diseases, Hacettepe University Medical Faculty, Ankara, Turkey dckoksal@gmail.com.
authors.forename: Deniz
authors.initials: D
authors.lastname: Koksal
authors.affiliation: Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Safak
authors.affiliation: Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Aysenaz
authors.initials: A
authors.lastname: Ozcan
authors.affiliation: Department of Pathology, Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Agackiran
authors.affiliation: Department of Radiology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Erturk
authors.affiliation: Department of Chest Surgery, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: Gokturk
authors.initials: G
authors.lastname: Findik
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000453:epidemiology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology*; D010997:Pleural Neoplasms / Q000097:blood / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000097:blood / Q000453:epidemiology*; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000097:blood / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000097:blood / Q000453:epidemiology*
keywords: malignant pleural mesothelioma; thromboembolic event; thrombosis