title: Fetal cardiac biometry and function in HIV-infected pregnant women exposed to HAART therapy.
abstract: OBJECTIVE
  Previous studies have suggested that antiretroviral therapy in human immunodeficiency virus (HIV)-infected pregnant women can cause alterations in cardiac structure and function in fetuses or children, although the results are not very clear. The aim of this study is to assess whether or not these alterations are present in the heart of fetuses of HIV-infected pregnant women, undergoing treatment with highly active antiretroviral therapy (HAART).
  
  
  METHODS
  We performed a prospective study on 29 consecutive HIV-positive pregnant women treated with HAART and 70 consecutive HIV-negative pregnant women as controls. Fetal cardiac biometry and function was evaluated by echocardiography at 30-32 weeks of gestation. Fetal biometry, estimated fetal weight and umbilical artery Doppler were also measured.
  
  
  RESULTS
  We found E/A tricuspid ratio values slightly increased (0.84 vs 0.80, p = 0.03) and diastolic length shortened (49.7 vs 51.7%, p = 0.03) in the HIV-infected group. The rest of the biometric and functional cardiac parameters were not different between both groups. There were no cases of vertical transmission of HIV infection.
  
  
  CONCLUSIONS
  In HIV-infected pregnant women treated with HAART, no significant changes are showed in fetal cardiac parameters.
authors.affiliation: Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University Hospital La Paz, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: De la Calle
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez
authors.forename: L
authors.initials: L
authors.lastname: Deirós
authors.forename: J L
authors.initials: JL
authors.lastname: Bartha
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001699:Biometry; D016022:Case-Control Studies; D015331:Cohort Studies; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging* / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy*; D006351:Heart Valves / Q000000981:diagnostic imaging*; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011446:Prospective Studies