title: Adiponectin is not associated with blood pressure in normotensives and untreated hypertensives with normal kidney function.
abstract: The role of adiponectin in hypertension is still a matter of debate. Obtained conflicting results could be mostly explained with diversity of subjects included in different studies. Our aim was to analyze association of adiponectin with blood pressure (BP) in a group of normotensive and untreated hypertensive subjects. Participants (N=257) were selected from a random sample of 2487 subjects enrolled in an observational cross-sectional study. Subjects with diabetes and chronic kidney diseases were excluded. BP was measured using Omron M6 device following ESH/ESC guidelines. Adiponectin concentration was determined by ELISA. There were no differences in adiponectin values (mg/L) between hypertensives and normotensives (median 9.75; iqr: 7.44-17.88 vs 11.35; iqr: 7.43-12.63; P=0.17). On univariate linear regression adiponectin was not associated with systolic or diastolic BP (P>0.05). Furthermore, multivariate analysis did not show significant contribution of log-transformed adiponectin either to systolic (β=-0.040; P=0.43) or diastolic BP (β=0.066; P=0.33). In our group of normotensives and untreated hypertensives with normal kidney function adiponectin was not associated with BP even after adjustment for other risk factors. Our results and conclusions should not be extrapolated to subjects with other characteristics.
authors.affiliation: From the School of Medicine, University of Zagreb, Croatia (VI, MJ); School of Medicine, University of Zagreb, Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Croatia (ML, AV, SK, JK, TZ, VP, MZ, BJ); School of Medicine, University of Zagreb, Department of Metabolic Disorders, University Hospital Center Zagreb, Zagreb, Croatia (IP); and School of Medicine University of Zagreb, Clinical Department for Laboratory Diagnosis, University Hospital Center Zagreb, Zagreb, Croatia (MF, TB).
authors.forename: Vanja
authors.initials: V
authors.lastname: Ivković
authors.forename: Mislav
authors.initials: M
authors.lastname: Jelaković
authors.forename: Mario
authors.initials: M
authors.lastname: Laganović
authors.forename: Ivan
authors.initials: I
authors.lastname: Pećin
authors.forename: Ana
authors.initials: A
authors.lastname: Vrdoljak
authors.forename: Sandra
authors.initials: S
authors.lastname: Karanović
authors.forename: Mirjana
authors.initials: M
authors.lastname: Fuček
authors.forename: Tamara
authors.initials: T
authors.lastname: Božina
authors.forename: Jelena
authors.initials: J
authors.lastname: Kos
authors.forename: Tajana
authors.initials: T
authors.lastname: Željković Vrkić
authors.forename: Vedran
authors.initials: V
authors.lastname: Premužić
authors.forename: Marijana
authors.initials: M
authors.lastname: Živko
authors.forename: Bojan
authors.initials: B
authors.lastname: Jelaković
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D017523:Croatia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D015994:Incidence; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers