title: Altered resting-state connectivity in college students with nonclinical depressive symptoms.
abstract: BACKGROUND
  The underlying brain basis of nonclinical depressive symptoms (nCDSs) is largely unknown. Recently, the seed-based functional connectivity (FC) approach for analyzing resting-state fMRI (rs-fMRI) data has been increasingly used to explore the neural basis of depressive disorders. Other than common seed-based FC method using an a priori seed region, we conducted FC analysis based on regions with altered spontaneous activity revealed by the fractional amplitude of low-frequency fluctuations (fALFF) approach. The aim of the present study was to provide novel insight in the underlying mechanism of nCDSs in college students.
  
  
  RESULTS
  A total number of 1105 college students were recruited to participant in a survey for assessing depressive symptoms. Subsequently, 17 individuals with nCDSs and 20 healthy controls (HCs) were enrolled to perform MR studies. Alternations of fALFF were identified in the right superior parietal lobule (SPL) and left lingual gyrus, both of which were used as ROIs for further FC analysis. With right SPL, compare with HCs, subjects with nCDSs showed reduced FCs in the bilateral dorsal lateral prefrontal cortex (DLPFC), left inferior frontal gurus (IFG), left premotor cortex (PMC), DMN network [i.e., bilateral precuneus, posterior cingulate cortex (PCC), right supramarginal gyrus (SMG), right parahippocampal gyrus (PHG), bilateral inferior temporal gurus (ITG)] and left cerebellum posterior lobe (CPL). In addition, increased FCs were observed between the left lingual gyrus and right fusiform gyrus as well as in the left precuneus.
  
  
  CONCLUSIONS
  Our results indicate the abnormalities of spontaneous activity in the right SPL and left lingual gyrus and their corresponding dysfunction of the brain circuits might be related to the pathophysiology of nCDSs.
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Radiology, Tiantan hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Huicong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Ruimeng
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Lai
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Radiology, Wayne State University, Detroit, Michigan, 48202, United States of America.
authors.forename: Jiani
authors.initials: J
authors.lastname: Hu
authors.affiliation: Faculty of Health Management, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiology, the affiliated Guangzhou first hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510180, China.
authors.forename: Xinqing
authors.initials: X
authors.lastname: Jiang
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D003863:Depression / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology*; D012146:Rest; D013334:Students; D014495:Universities; D055815:Young Adult