title: Parent, dentist, and orthodontist satisfaction following alveolar cleft repair using recombinant human bone morphogenic protein.
abstract: Our aim was to evaluate dental/orthodontic outcomes for patients who underwent recombinant human bone morphogenic protein (rhBMP-2) alveolar cleft repair and to examine parental satisfaction following the procedure. Design Retrospective review. Setting Tertiary children's hospital. Participants Parents, dentists, and orthodontists completed satisfaction questionnaires. Main Outcome Measures Parent, dentist, and orthodontist satisfaction with the use of rhBMP-2 in alveolar cleft repair. Results Parent response rate was 71.4% (30/42). The dentist response rate was 60% (18/30). The orthodontist response rate was 53.3% (16/30). Parent and patient satisfaction was 93.3% and 83.3%, respectively. Of dentist respondents, 55.6% reported that the bone quality and alveolar ridge mucosal repair allowed for dental treatment. Of orthodontist respondents, 87.5% reported the graft enabled treatment, and 73.3% felt the graft prevented tooth root exposure and resorption. Conclusions Parents, dentists, and orthodontists are satisfied with outcomes when rhBMP-2 is used for alveolar cleft repair. The bone formed was reported as adequate to support dental and orthodontic treatment in most cases with few complications. Because of safety concerns over the use of this product in an off-label manner, further controlled studies are warranted.
authors.forename: Justin
authors.initials: J
authors.lastname: Wudel
authors.forename: Sondra
authors.initials: S
authors.lastname: Valdez
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Perkins
authors.forename: Conan
authors.initials: C
authors.lastname: Liang
authors.forename: Ashley
authors.initials: A
authors.lastname: Blanchard
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Allen
mesh_terms: D064728:Alveolar Bone Grafting; D000539:Alveolar Process / Q000002:abnormalities*; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D002648:Child; D002972:Cleft Palate / Q000628:therapy*; D003815:Dentists / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009972:Orthodontics, Interceptive; D000066792:Orthodontists / Q000523:psychology*; D010290:Parents / Q000523:psychology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins
keywords: alveolar cleft; bone grafting; bone morphogenic protein; rhBMP-2; satisfaction survey