title: Updated meta-analysis on HER2 polymorphisms and risk of breast cancer: evidence from 32 studies.
abstract: BACKGROUND
  Several studies have been performed to investigate the association of the HER2 Ile655Val polymorphism and breast cancer risk. However, the results were inconsistent. To understand the precise relationship, a meta-analysis was here conducted.
  
  
  METHODS
  A search of PubMed conducted to investigate links between the HER2 Ile655Val polymorphism and breast cancer, identified a total of 32 studies, of which 29, including 14,926 cases and 15,768 controls, with odds ratios (ORs) with 95% confidence intervals were used to assess any association.
  
  
  RESULTS
  In the overall analysis, the HER2 Ile655Val polymorphism was associated with breast cancer in an additive genetic model (OR=1.136, 95% CI 1.043-1.239, p=0.004) and in a dominant genetic (OR=1.118, 95% CI 1.020-1.227, p=0.018), while no association was found in a recessive genetic model. On subgroup analysis, an association with breast cancer was noted in the additive genetic model (OR=1.111, 95% CI: 1.004-1.230, p=0.042) for the Caucasian subgroup. No significant associations were observed in Asians and Africans in any of the genetic models.
  
  
  CONCLUSIONS
  In summary, our meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China E-mail : cherrychen2008@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Heng
authors.initials: H
authors.lastname: Yang
authors.forename: Wen-Ru
authors.initials: WR
authors.lastname: Tang
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Feng
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Wei
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D012306:Risk
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human