title: Oxytocin induces positive expectations about ambivalent stimuli (cognitive bias) in dogs.
abstract: Expectancy bias towards positive outcomes is a potential key to subjective well-being, and has been widely investigated in different species. Here we test whether oxytocin, suggested to play a role in human optimism and emotional processing, influences how dogs judge ambivalent situations (in a cognitive bias paradigm). Subjects first learned in a location discrimination task that a bowl either contained food (at the 'positive' location) or was empty (at the 'negative' location). Then, after receiving oxytocin or placebo nasal spray, they were presented with the bowl located halfway between the positive and negative positions in communicative or non-communicative contexts (N=4×16). A Positive Expectancy Score was calculated for each subject using the latency to approach this ambivalent location. Compared to placebo groups, subjects that received oxytocin pretreatment showed a positive expectation bias in both contexts, and this effect was more pronounced in the communicative context. Our study provides the first evidence for the impact of oxytocin on dogs' judgement bias and also shows that the social-communicative nature of the task situation modulates the effect of oxytocin.
authors.affiliation: Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary; Department of Ethology, Eötvös University, Pázmány Péter stny. 1/c, 1117 Budapest, Hungary. Electronic address: vargane.kis.anna@ttk.mta.hu.
authors.forename: Anna
authors.initials: A
authors.lastname: Kis
authors.affiliation: Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary; Department of Ethology, Eötvös University, Pázmány Péter stny. 1/c, 1117 Budapest, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Hernádi
authors.affiliation: Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, PD, Italy.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Kanizsár
authors.affiliation: MTA-ELTE Comparative Ethology Research Group, Pázmány Péter stny. 1/c, 1117 Budapest, Hungary.
authors.forename: Márta
authors.initials: M
authors.lastname: Gácsi
authors.affiliation: Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Topál
mesh_terms: D000281:Administration, Intranasal; D000339:Affect / Q000187:drug effects*; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004285:Dogs; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D010805:Physical Conditioning, Animal / Q000502:physiology / Q000523:psychology; D011930:Reaction Time / Q000187:drug effects
chemical_list: D010121:Oxytocin
keywords: Canis familiaris; Dog; Expectation bias; Oxytocin