title: Insulin resistance in adult primary care patients with a surrogate index, Guadalajara, Mexico, 2012.
abstract: BACKGROUND
  Insulin resistance (IR) is a key molecular disorder related with diabetes mellitus, obesity, and cardiovascular disease. The objective of this study was to determine IR in adult primary care patients using the triglyceride/glucose (TyG) index [(Ln TG (mg/dL) × FG (mg/dL))/2].
  
  
  METHODS
  We conducted a cross-sectional secondary analysis and identified IR subjects according to the TyG index.
  
  
  RESULTS
  There were 1500 patients included. Significant differences were found between the IR group versus the insulin-sensitive group, respectively: age (in years), 46.4 ± 9.34 versus 40.24 ± 11.27 (P < 0.001); fasting glucose (mg/dL), 99.87 ± 11.95 versus 84.62 ± 6.59 (P < 0.001); total cholesterol (mg/dL), 203.21 ± 37.38 versus 173.91 ± 33.99 (P < 0.001); triglycerides (mg/dL), 226.40 ± 96.66 versus 111.27 ± 23.44 (P < 0.001); uric acid (mg/dL), 6.09 ± 1.59 versus 4.77 ± 1.40 (P < 0.001); and TyG index, 4.96 ± 0.21 versus 4.48 ± 0.13 (P < 0.001). The cutoff of the TyG index for IR was 4.68 or greater.
  
  
  CONCLUSIONS
  The TyG index allows for early diagnosis of IR in primary health care.
authors.affiliation: From the *Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS; †Unidad de Medicina Familiar Número 3, Delegación Jalisco; and ‡Instituto de Terapéutica Experimental y Clínica (INTEC), Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: María Claudia
authors.initials: MC
authors.lastname: Espinel-Bermúdez
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Robles-Cervantes
authors.forename: Liliana
authors.initials: L
authors.lastname: del Sagrario Villarreal-Hernández
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Villaseñor-Romero
authors.forename: Sandra Ofelia
authors.initials: SO
authors.lastname: Hernández-González
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
authors.forename: Karina Griselda
authors.initials: KG
authors.lastname: Pérez-Rubio
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011320:Primary Health Care; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides