title: Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy.
abstract: OBJECTIVE
  To evaluate serum concentrations of biochemical markers and survival time in dogs with protein-losing enteropathy (PLE).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  29 dogs with PLE and 18 dogs with food-responsive diarrhea (FRD).
  
  
  METHODS
  Data regarding serum concentrations of various biochemical markers at the initial evaluation were available for 18 of the 29 dogs with PLE and compared with findings for dogs with FRD. Correlations between biochemical marker concentrations and survival time (interval between time of initial evaluation and death or euthanasia) for dogs with PLE were evaluated.
  
  
  RESULTS
  Serum C-reactive protein concentration was high in 13 of 18 dogs with PLE and in 2 of 18 dogs with FRD. Serum concentration of canine pancreatic lipase immunoreactivity was high in 3 dogs with PLE but within the reference interval in all dogs with FRD. Serum α1-proteinase inhibitor concentration was less than the lower reference limit in 9 dogs with PLE and 1 dog with FRD. Compared with findings in dogs with FRD, values of those 3 variables in dogs with PLE were significantly different. Serum calprotectin (measured by radioimmunoassay and ELISA) and S100A12 concentrations were high but did not differ significantly between groups. Seventeen of the 29 dogs with PLE were euthanized owing to this disease; median survival time was 67 days (range, 2 to 2,551 days).
  
  
  CONCLUSIONS
  Serum C-reactive protein, canine pancreatic lipase immunoreactivity, and α1-proteinase inhibitor concentrations differed significantly between dogs with PLE and FRD. Most initial biomarker concentrations were not predictive of survival time in dogs with PLE.
authors.affiliation: Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, 3001 Switzerland.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Equilino
authors.forename: Vincent
authors.initials: V
authors.lastname: Théodoloz
authors.forename: Daniela
authors.initials: D
authors.lastname: Gorgas
authors.forename: Marcus G
authors.initials: MG
authors.lastname: Doherr
authors.forename: Romy M
authors.initials: RM
authors.lastname: Heilmann
authors.forename: Jan S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: Jörg M
authors.initials: JM
authors.lastname: Steiner
authors.forename: Iwan A
authors.initials: IA
authors.lastname: Burgener Dvm
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology; D004285:Dogs; D005260:Female; D005492:Folic Acid / Q000097:blood; D005512:Food Hypersensitivity / Q000097:blood / Q000662:veterinary*; D007249:Inflammation / Q000097:blood / Q000378:metabolism / Q000662:veterinary; D008136:Longevity; D008297:Male; D011504:Protein-Losing Enteropathies / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D012709:Serum Albumin; D014357:Trypsin / Q000276:immunology; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D012709:Serum Albumin; D005492:Folic Acid; D014357:Trypsin; D014805:Vitamin B 12; D002118:Calcium