title: Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets.
abstract: A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Carrington
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Indranil
authors.initials: I
authors.lastname: Chakraborty
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: Jenna M L
authors.initials: JM
authors.lastname: Bernard
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
keywords: CO delivery; Carbon monoxide; apoptosis; fluorescence tracking; photoactive metal carbonyls