title: A multifunctional probe with aggregation-induced emission characteristics for selective fluorescence imaging and photodynamic killing of bacteria over mammalian cells.
abstract: A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.
authors.affiliation: Institute of Materials Research Engineering (A*STAR), 3 Research Link, Singapore, 117602.
authors.forename: Meng
authors.initials: M
authors.lastname: Gao
authors.forename: Qinglian
authors.initials: Q
authors.lastname: Hu
authors.forename: Guangxue
authors.initials: G
authors.lastname: Feng
authors.forename: Nikodem
authors.initials: N
authors.lastname: Tomczak
authors.forename: Rongrong
authors.initials: R
authors.lastname: Liu
authors.forename: Bengang
authors.initials: B
authors.lastname: Xing
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000528:radiation effects; D048430:Cell Shape / Q000187:drug effects / Q000528:radiation effects; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019169:Jurkat Cells; D020014:K562 Cells; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D015335:Molecular Probes / Q000737:chemistry / Q000494:pharmacology; D061848:Optical Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D010848:Picolinic Acids / Q000737:chemistry / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D010848:Picolinic Acids; C529174:bis-dipicolylamine-Zinc(II)
keywords: ESIPT; aggregation-induced emission; bacteria; fluorescent probes; photodynamic therapy