title: Detection of circulating tumour cells in peripheral blood of patients with malignant pleural mesothelioma.
abstract: BACKGROUND
  The independent prognostic value of Circulating Tumour Cells (CTC) level has been demonstrated in several solid tumours. There is currently few data on Malignant Pleural Mesothelioma (MPM) and CTC. We investigated whether the presence of CTC was correlated with prognosis factors and treatment efficacy.
  
  
  OBJECTIVE
  MPM patients (pts) were enrolled in a prospective monocentric study. CTC detection was made using the "CellSearch" assay. The correlation between the presence of CTC and worse prognosis factors was assessed using the X(2) test. Comparison of Overall Survival (OS) and Progression Free Survival (PFS) according to CTC detection was performed using the log-rank test.
  
  
  RESULTS
  Twenty-seven MPM pts with a median follow-up of 4.2 months were included. CTC were detected in 44% of pts with a median level of 1.5. No significant correlation was observed between the presence of CTC and worse prognosis factors. Moreover, CTC detection was not a significant predictor of OS or PFS (p=0.155 and p=0.32 respectively).
  
  
  CONCLUSIONS
  CTC were detected in a small cohort of MPM patients. We couldn't demonstrate a significant prognostic value or a difference in OS/PFS between CTC levels. Further analyses, validation studies and detection techniques are needed to establish their real clinical value in MPM.
authors.affiliation: Thoracic Group, INSERM U981, Gustave Roussy, Villejuif, France Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Raphael
authors.affiliation: Thoracic Group, INSERM U981, Gustave Roussy, Villejuif, France Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
authors.affiliation: Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Inna Y
authors.initials: IY
authors.lastname: Gong
authors.affiliation: Translational Research Laboratory, Gustave Roussy, Villejuif, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Farace
authors.affiliation: Department of Medical Oncology, Gustave Roussy, Villejuif, France Pulmonary Department, Percy Hospital, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Margery
authors.affiliation: Translational Research Laboratory, Gustave Roussy, Villejuif, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Billiot
authors.affiliation: Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Hollebecque
authors.affiliation: Thoracic Group, INSERM U981, Gustave Roussy, Villejuif, France Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Besse
authors.affiliation: Thoracic Group, INSERM U981, Gustave Roussy, Villejuif, France Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
authors.affiliation: Thoracic Group, INSERM U981, Gustave Roussy, Villejuif, France Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: David
authors.initials: D
authors.lastname: Planchard
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology*; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor
keywords: Malignant pleural mesothelioma; circulating tumour cells; overall survival.; prognosis factors; progression free survival