title: Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
abstract: Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). This cross-sectional study included 24 patients aged 20-38 years, who were diagnosed to have PCOS (patient group). The control group included 16 age- and body mass index-matched healthy female volunteers. The patients and controls were compared in terms of pre-prandial blood glucose, the homoeostatic model assessment for insulin resistance (HOMA-IR) index, and cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP) and sirtuin 1 levels. The mean sirtuin 1 level in the patient group (6.67 ± 2.29 ng mL(-1)) was significantly higher than that in the control group (4.69 ± 1.85 ng mL(-1)) (P = 0.007). Correlation analysis showed that there were no significant differences between the groups in fasting blood glucose, HOMA-IR index or cholesterol, triglyceride, HD, LDL and CRP levels. The sirtuin 1 level, which is associated with inflammation, the immune system and insulin metabolism, was higher in the PCOS patients than in the healthy controls.
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Kiyak Caglayan
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey.|c Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.affiliation: b Department of Biochemistry , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Ayse Yesim
authors.initials: AY
authors.lastname: Gocmen
authors.affiliation: b Department of Biochemistry , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Muhammet Fevzi
authors.initials: MF
authors.lastname: Polat
authors.affiliation: c Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Aktulay
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D056564:Sirtuin 1 / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008055:Lipids; D002097:C-Reactive Protein; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: PCOS; sirtuin 1