title: Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer.
abstract: Recent studies have shown that long non‑coding RNAs (lncRNAs) have crucial regulating roles in carcinogenesis. Forkhead box C1 (FOXC1) is an important cancer‑associated gene in basal‑like breast cancer (BLBC). In the present study, a novel lncRNA, FOXC1 promoter upstream transcript (FOXCUT) was investigated in BLBC patients using polymerase chain reaction analysis. The results showed that the expression of FOXCUT and FOXC1 were positively correlated. When the expression of FOXCUT was downregulated by small interfering RNA, the expression of FOXC1 was similarly reduced. Furthermore, in MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells, knockdown of FOXCUT markedly inhibited cell proliferation and migration in vitro. In conclusion, FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs.
authors.affiliation: Department of General Thoracic Surgery, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Oncology, PLA Center Hospital, Wuhan, Hubei 430000, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yao
authors.affiliation: Oncology Department, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Orthopedics Department, Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, Kunming General Hospital of Chendu Military Command, Kunming, Yunnan 650032, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Oncology Department, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D018295:Neoplasms, Basal Cell / Q000235:genetics*; D011401:Promoter Regions, Genetic; D062085:RNA, Long Noncoding / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering
chemical_list: C112743:FOXC1 protein, human; D051858:Forkhead Transcription Factors; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D034741:RNA, Small Interfering