title: First report of a multidrug-resistant Klebsiella pneumoniae of sequence type 11 causing sepsis in a free-ranging beaver (Castor fiber).
abstract: Klebsiella pneumoniae of sequence type (ST) 11 is a hyper-epidemic nosocomial clone spreading worldwide among humans and also emerging in pets. In this report, we describe a clinical case of fatal sepsis due to this multidrug-resistant (MDR) pathogen in a Eurasian beaver. The isolate showed resistance to six different classes of antimicrobials including third generation cephalosporins and fluoroquinolones. This is the first report describing the detection of a MDR K. pneumoniae ST11 in a free-ranging animal. Our finding highlights the potential for environmental dissemination of hyper-epidemic clones of K. pneumoniae and possible spread in wildlife and cause epizootics.
authors.affiliation: Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
authors.forename: Paola
authors.initials: P
authors.lastname: Pilo
authors.forename: Debora
authors.initials: D
authors.lastname: Vogt
authors.forename: Francesco C
authors.initials: FC
authors.lastname: Origgi
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Susanne
authors.initials: S
authors.lastname: Peterson
authors.forename: Vincent
authors.initials: V
authors.lastname: Perreten
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D005838:Genotype; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D058885:Multilocus Sequence Typing; D012377:Rodentia / Q000382:microbiology*; D018805:Sepsis / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents