title: Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia.
abstract: OBJECTIVE
  To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QTc interval.
  
  
  METHODS
  This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n:5) and neostigmine group (Group N, n:5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2, 5, 10, 20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex.
  
  
  RESULTS
  Comparing the QTc interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QTc interval in the neostigmine group rabbits was significantly increased (p<0.05).
  
  
  CONCLUSIONS
  While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QTc interval, neostigmine+atropine proloned the QTc interval.
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbaş
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Toman
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Şahin
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Kiraz
authors.affiliation: Department of Cardiology, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutcu
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Simsek
authors.affiliation: Department of Cardiovascular Surgery, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Ali Umit
authors.initials: AU
authors.lastname: Yener
authors.affiliation: Department of Physiology, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Metehan
authors.initials: M
authors.lastname: Uzun
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Altinişik
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000379:methods*; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D009388:Neostigmine / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D002800:Cholinesterase Inhibitors; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine; D000077123:Rocuronium