title: Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats.
abstract: Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated. Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of hepatotoxicity and nephrotoxicity via the oral administration of a single dose of APAP (2 g/kg). Organ damage was confirmed by measuring the elevation of serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine, and malondialdehyde (MDA). Histopathological alterations observed in the livers and the kidneys further confirmed oxidative damage to these tissues. Animals pretreated with Sundarban honey showed significantly markedly reduced levels of all of the investigated parameters. In addition, Sundarban honey ameliorated the altered hepatic and renal morphology in APAP-treated rats. Overall, our findings indicate that Sundarban honey protects against APAP-induced acute hepatic and renal damage, which could be attributed to the honey's antioxidant properties.
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Rizwana
authors.identifier: 0000-0003-1108-3406
authors.initials: R
authors.lastname: Afroz
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: E M
authors.initials: EM
authors.lastname: Tanvir
authors.affiliation: Department of Agriculture Biology, Faculty of Agriculture, University of Ruhuna, 81100 Wellmadama, Matara, Sri Lanka.
authors.forename: Md Fuad
authors.identifier: 0000-0002-0977-4593
authors.initials: MF
authors.lastname: Hossain
authors.affiliation: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
authors.affiliation: Dhaka Shishu (Children) Hospital & Bangladesh Institute of Children Health (BCIH), Sher-E-Bangla Nagar, Dhaka 1207, Bangladesh.
authors.forename: Mashud
authors.initials: M
authors.lastname: Parvez
authors.affiliation: Department of Biochemistry, International Medical College, Tongi, Gazipur 1712, Bangladesh.
authors.forename: Md
authors.initials: M
authors.lastname: Aminul Islam
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Md Ibrahim
authors.initials: MI
authors.lastname: Khalil