title: Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society.
abstract: OBJECTIVE
  The purpose of this statement is to review the literature regarding mitochondrial disease and to provide recommendations for optimal diagnosis and treatment. This statement is intended for physicians who are engaged in diagnosing and treating these patients.
  
  
  METHODS
  The Writing Group members were appointed by the Mitochondrial Medicine Society. The panel included members with expertise in several different areas. The panel members utilized a comprehensive review of the literature, surveys, and the Delphi method to reach consensus. We anticipate that this statement will need to be updated as the field continues to evolve.
  
  
  RESULTS
  Consensus-based recommendations are provided for the diagnosis and treatment of mitochondrial disease.
  
  
  CONCLUSIONS
  The Delphi process enabled the formation of consensus-based recommendations. We hope that these recommendations will help standardize the evaluation, diagnosis, and care of patients with suspected or demonstrated mitochondrial disease.
authors.affiliation: Department of Neurology, Center for Child Neurology, Cleveland Clinic Children's Hospital, Cleveland, Ohio, USA.
authors.forename: Sumit
authors.identifier: http://orcid.org/0000-0003-3712-8959
authors.initials: S
authors.lastname: Parikh
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Amy
authors.identifier: http://orcid.org/0000-0002-7675-3063
authors.initials: A
authors.lastname: Goldstein
authors.affiliation: Department of Pediatrics, Division of Child and Adolescent Neurology, University of Texas Medical School at Houston, Houston, Texas, USA.
authors.forename: Mary Kay
authors.identifier: http://orcid.org/0000-0001-5126-8515
authors.initials: MK
authors.lastname: Koenig
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
authors.forename: Fernando
authors.initials: F
authors.lastname: Scaglia
authors.affiliation: Department of Pediatrics, Division of Medical Genetics, Stanford University Lucile Packard Children's Hospital, Palo Alto, California, USA.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Enns
authors.affiliation: Department of Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.|Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Saneto
authors.affiliation: Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Anselm
authors.affiliation: Department of Pediatrics, NeuroDevelopmental Science Center, Children's Hospital Medical Center of Akron, Akron, Ohio, USA.
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Cohen
authors.affiliation: Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Marni J
authors.initials: MJ
authors.lastname: Falk
authors.affiliation: Department of Pediatrics, University of Maryland Medical Center, Baltimore, Maryland, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Greene
authors.affiliation: Department of Neurology, Children's National Medical Center and the George Washington University of the Health Sciences, Washington, DC, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Gropman
authors.affiliation: Department of Neurosciences and Pediatrics, UCSD Medical Center and Rady Children's Hospital San Diego, La Jolla, California, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Haas
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York, New York, USA.
authors.forename: Michio
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Department of Anesthesiology, Seattle Children's Hospital, Seattle, Washington, USA.
authors.forename: Phil
authors.initials: P
authors.lastname: Morgan
authors.affiliation: Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Sims
authors.affiliation: Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Tarnopolsky
authors.affiliation: Department of Pediatrics, Clinical Genetics and Metabolism, Children's Hospital Colorado, Denver, Colorado, USA.
authors.forename: Johan L K
authors.initials: JL
authors.lastname: Van Hove
authors.affiliation: National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Lynne
authors.initials: L
authors.lastname: Wolfe
authors.affiliation: Department of Neurology, Columbia University Medical Center, New York, New York, USA.
authors.forename: Salvatore
authors.initials: S
authors.lastname: DiMauro
mesh_terms: D032921:Consensus; D003697:Delphi Technique; D019317:Evidence-Based Medicine; D006801:Humans; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome