title: Comparing the power of family-based association tests for sequence data with applications in the GAW18 simulated data.
abstract: We apply a family-based extension of the sequence kernel association test (SKAT) to 93 trios extracted from the 20 pedigrees in the Genetic Analysis Workshop 18 simulated data. Each extracted trio includes a unique set of parents to ensure conditionally independent trios are sampled. We compare the empirical type I error and power between the family-based SKAT and the burden test under varying percentages of causal single-nucleotide polymorphisms included in the analysis. Our investigation using simulated data suggests that, under the setting used for Genetic Analysis Workshop 18 data, both the family-based SKAT and the burden test have limited power, and that there is no substantial impact of percentage of signal on the power of either test. The low power is partially a result of the small sample size. However, we find that both the family-based SKAT and the burden test are more powerful when we use only rare variants, rather than common variants, to test the association.
authors.affiliation: Division of Biostatistics, University of Texas School of Public Health, Houston, TX 77030, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Division of Biostatistics, University of Texas School of Public Health, Houston, TX 77030, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Division of Biostatistics, University of Texas School of Public Health, Houston, TX 77030, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Swartz
authors.affiliation: Department of Biostatistics, Columbia University, Mailman School of Public Health, New York City, NY 10032, USA.
authors.forename: Iuliana
authors.initials: I
authors.lastname: Ionita-Laza