title: Mitochondrial changes in endometrial carcinoma: possible role in tumor diagnosis and prognosis (review).
abstract: Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Cormio
authors.affiliation: Gynecologic Oncology Unit, IRCCS Istituto Oncologico 'Giovanni Paolo II', Bari, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Cormio
authors.affiliation: CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Musicco
authors.affiliation: Department of Basical Medical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Sardanelli
authors.affiliation: Department of Medical and Surgical Sciences, Unit of Medical Genetics, University of Bologna, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gasparre
authors.affiliation: CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy.
authors.forename: Maria Nicola
authors.initials: MN
authors.lastname: Gadaleta
mesh_terms: D004272:DNA, Mitochondrial; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000473:pathology*; D009154:Mutation
chemical_list: D004272:DNA, Mitochondrial