title: Reviewing the serotonin reuptake inhibitors (SSRIs) footprint in the aquatic biota: uptake, bioaccumulation and ecotoxicology.
abstract: Selective serotonin re-uptake inhibitors (SSRIs) antidepressants are amongst the most prescribed pharmaceutical active substances throughout the world. Their presence, already described in different environmental compartments such as wastewaters, surface, ground and drinking waters, and sediments, and their remarkable effects on non-target organisms justify the growing concern about these emerging environmental pollutants. A comprehensive review of the literature data with focus on their footprint in the aquatic biota, namely their uptake, bioaccumulation and both acute and chronic ecotoxicology is presented. Long-term multigenerational exposure studies, at environmental relevant concentrations and in mixtures of related compounds, such as oestrogenic endocrine disruptors, continue to be sparse and are imperative to better know their environmental impact.
authors.affiliation: REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal. Electronic address: ljgsilva@hotmail.com.
authors.forename: Liliana J G
authors.initials: LJG
authors.lastname: Silva
authors.affiliation: REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
authors.forename: André M P T
authors.initials: AMPT
authors.lastname: Pereira
authors.affiliation: INFARMED, I.P. - National Authority of Medicines and Health Products, Parque de Saúde de Lisboa - Avenida do Brasil, 53, 1749-004 Lisboa, Portugal; Department of Pharmacology, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Leonor M
authors.initials: LM
authors.lastname: Meisel
authors.affiliation: REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
authors.forename: Celeste M
authors.initials: CM
authors.lastname: Lino
authors.affiliation: REQUIMTE, Group of Bromatology, Pharmacognosy and Analytical Sciences, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
authors.forename: Angelina
authors.initials: A
authors.lastname: Pena
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000187:drug effects / Q000378:metabolism*; D058448:Biota; D054750:Ecotoxicology; D004777:Environment; D004785:Environmental Pollutants; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D017367:Selective Serotonin Reuptake Inhibitors; D014874:Water Pollutants, Chemical
keywords: Bioaccumulation; Ecotoxicology; Environmental contaminants; Selective serotonin re-uptake inhibitors; Uptake