title: [PET radiopharmaceuticals: novelties and new possibilities].
abstract: 18F-fluoro-deoxyglucose (FDG) can be considered as the "work-horse" of PET/CT and PET/MR imaging modalities. FDG provides insight in the pathophysiology of tumors and metastases from the point of view of sugar consumption. On the other hand, amino acid metabolism, expression of various receptors in the cells or on the surface of the cells, angiogenesis, appearance of hypoxic cells/tissues and apoptosis also participate in the pathophysiological processes and may have importance in determining the treatment strategy for patients or in monitoring the chosen therapy. Many molecules involved can be labeled by (18)F radionuclide but certain metabolisms require (11)C-labelled agents. Molecular imaging is of key importance in cancer research and various metal complexes containing (44)Sc, (64)Cu, (68)Ga, (86)Y, (89)Zr positron emitters can be very useful in this activity.
authors.affiliation: Izotóp Intézet Kft., Budapest, Hungary. kornyei@izotop.hu.
authors.forename: József
authors.initials: J
authors.lastname: Környei
authors.affiliation: Nukleáris Medicina Intézet, Debreceni Egyetem Klinikai Központ, Debrecen, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Mikecz
authors.affiliation: Pozitron-Diagnosztika Kft., Budapest, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Tóth
mesh_terms: D002250:Carbon Radioisotopes; D003301:Copper Radioisotopes; D004583:Electrons; D005462:Fluorine Radioisotopes; D005710:Gallium Radioisotopes; D006207:Half-Life; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012538:Scandium; D015021:Yttrium Radioisotopes; D015040:Zirconium
chemical_list: D002250:Carbon Radioisotopes; D003301:Copper Radioisotopes; D005462:Fluorine Radioisotopes; D005710:Gallium Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D015040:Zirconium; D012538:Scandium