title: Multicomponent strategy to indeno[2,1-c]pyridine and hydroisoquinoline derivatives through cleavage of carbon–carbon bond.
abstract: A concise and efficient three-component domino reaction has been developed for the synthesis of polyfunctionalized indenopyridine and hydroisoquinoline derivatives via the cleavage of a C–C bond under transition-metal-free conditions. This reaction provides facile access to complex nitrogen-containing heterocycles by simply mixing three common starting materials in EtOH in the presence of 20 mol % NaOH under microwave irradiation conditions.
authors.forename: Xian
authors.initials: X
authors.lastname: Feng
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Zhan
authors.initials: Z
authors.lastname: Xun
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D002244:Carbon / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007192:Indenes / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007192:Indenes; C472635:Indenopyridine hydrochloride; D011725:Pyridines; D002244:Carbon; D009584:Nitrogen