title: Gold finger formation studied by high-resolution mass spectrometry and in silico methods.
abstract: High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies were employed for characterizing the formation of two gold finger (GF) domains from the reaction of zinc fingers (ZF) with gold complexes. The influence of both the gold oxidation state and the ZF coordination sphere in GF formation provided useful insights into the possible design of new gold complexes targeting specific ZF motifs.
authors.affiliation: Biomolecular Mass Spectrometry Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors.forename: Ü A
authors.initials: ÜA
authors.lastname: Laskay
authors.forename: C
authors.initials: C
authors.lastname: Garino
authors.forename: Y O
authors.initials: YO
authors.lastname: Tsybin
authors.forename: L
authors.initials: L
authors.lastname: Salassa
authors.forename: A
authors.initials: A
authors.lastname: Casini
mesh_terms: D003198:Computer Simulation; D056831:Coordination Complexes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D016335:Zinc Fingers
chemical_list: D056831:Coordination Complexes; D006046:Gold