title: Self-assembled nanoparticles of acetylated cashew gum: characterization and evaluation as potential drug carrier.
abstract: Acetylated cashew gum (ACG) was synthesized and self-assembled nanoparticles were obtained through the dialysis of an organic solution (DMSO) against a non-solvent (water). The ACG was characterized by infrared spectroscopy. The degree of substitution was 2.8 as determined by NMR spectroscopy. The physicochemical properties of the self-assembled nanoparticles in aqueous media were characterized by DLS, SEM and fluorescence spectroscopy. The mean diameter of the self-assembled nanoparticles obtained was 179 nm and the critical aggregation concentration (CAC) in water was 2.1×10(-3) g/L. Indomethacin (IND) was used as a hydrophobic model drug and was incorporated into the hydrophobized polysaccharide. Both loaded and unloaded nanoparticles were found to be spherical with diameters in the ranges of 70-170 nm and 108-314 nm (determined by SEM), respectively. Controlled drug release was observed for up to 72 h.
authors.affiliation: Depto de Química Orgânica e Inorgânica-UFC-CEP, Caixa Postal 6021-R. Humberto Monte s/n, Campus do Pici, 60455-760 Fortaleza, Brazil.
authors.forename: Nadia A O
authors.initials: NAO
authors.lastname: Pitombeira
authors.affiliation: Depto de Química Orgânica e Inorgânica-UFC-CEP, Caixa Postal 6021-R. Humberto Monte s/n, Campus do Pici, 60455-760 Fortaleza, Brazil.
authors.forename: José Guilherme
authors.initials: JG
authors.lastname: Veras Neto
authors.affiliation: Departamento de Ciências do Mar-UFPI, Parnaiba Brazil.
authors.forename: Durcilene A
authors.initials: DA
authors.lastname: Silva
authors.affiliation: Depto de Química Orgânica e Inorgânica-UFC-CEP, Caixa Postal 6021-R. Humberto Monte s/n, Campus do Pici, 60455-760 Fortaleza, Brazil.
authors.forename: Judith P A
authors.initials: JPA
authors.lastname: Feitosa
authors.affiliation: Departamento de Química Analítica e Físico-Química-UFC, Fortaleza, Brazil.
authors.forename: Haroldo C B
authors.initials: HCB
authors.lastname: Paula
authors.affiliation: Depto de Química Orgânica e Inorgânica-UFC-CEP, Caixa Postal 6021-R. Humberto Monte s/n, Campus do Pici, 60455-760 Fortaleza, Brazil. Electronic address: rpaula@dqoi.ufc.br.
authors.forename: Regina C M
authors.initials: RCM
authors.lastname: de Paula
mesh_terms: D000107:Acetylation; D031021:Anacardium / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D053149:Plant Gums / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D053149:Plant Gums
keywords: Acetic anhydride (CID: 7918); Acetylation; Dimethyl sulfoxide (CID: 679); Drug release; Formamide (CID: 713); Hydrophobic cashew gum; Hydrophobic polysaccharide; Indomethacin; Indomethacin (CID: 3715); Nanoparticle; Pyridine (CID: 1049)