title: Cyclosporine treatment in severe gestational pemphigoid.
abstract: Gestational pemphigoid, a rare autoimmune skin disease typically occurring during pregnancy, is caused by autoantibodies against collagen XVII. Clinically it is characterised by severe itching followed by erythematous and bullous lesions of the skin. Topical or oral glucocorticoids usually relieve symptoms, but in more severe cases systemic immunosuppressive treatments are needed. Data on immunosuppressive medication controlling gestational pemphigoid are sparse. We report 3 intractable cases of gestational pemphigoid treated with cyclosporine.
authors.affiliation: Deparment of Dermatology, Medical Research Center, University of Oulu, Oulu University Hospital, P.B. 20, 90029 OYS, FIN-90220 Oulu, Finland. laura.huilaja@oulu.fi.
authors.forename: Laura
authors.initials: L
authors.lastname: Huilaja
authors.forename: Kaarin
authors.initials: K
authors.lastname: Mäkikallio
authors.forename: Katariina
authors.initials: K
authors.lastname: Hannula-Jouppi
authors.forename: Liisa
authors.initials: L
authors.lastname: Väkevä
authors.forename: Johanna
authors.initials: J
authors.lastname: Höök-Nikanne
authors.forename: Kaisa
authors.initials: K
authors.lastname: Tasanen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005387:Finland; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006559:Pemphigoid Gestationis / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D035583:Rare Diseases; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine