title: The roles of AXIN2 in tumorigenesis and epigenetic regulation.
abstract: AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, 130021, Jilin, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.forename: Shucheng
authors.initials: S
authors.lastname: Hua
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
mesh_terms: D060466:Axin Protein / Q000502:physiology*; D063646:Carcinogenesis; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D054875:Ubiquitination
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein; D035683:MicroRNAs; D034741:RNA, Small Interfering