title: Impact of nutrients on circadian rhythmicity.
abstract: The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an endogenous pacemaker that generates and maintains circadian rhythms throughout the body. Next to this central clock, peripheral oscillators exist in almost all mammalian tissues. Whereas the SCN is mainly entrained to the environment by light, peripheral clocks are entrained by various factors, of which feeding/fasting is the most important. Desynchronization between the central and peripheral clocks by, for instance, altered timing of food intake can lead to uncoupling of peripheral clocks from the central pacemaker and is, in humans, related to the development of metabolic disorders, including obesity and Type 2 diabetes. Diets high in fat or sugar have been shown to alter circadian clock function. This review discusses the recent findings concerning the influence of nutrients, in particular fatty acids and glucose, on behavioral and molecular circadian rhythms and will summarize critical studies describing putative mechanisms by which these nutrients are able to alter normal circadian rhythmicity, in the SCN, in non-SCN brain areas, as well as in peripheral organs. As the effects of fat and sugar on the clock could be through alterations in energy status, the role of specific nutrient sensors will be outlined, as well as the molecular studies linking these components to metabolism. Understanding the impact of specific macronutrients on the circadian clock will allow for guidance toward the composition and timing of meals optimal for physiological health, as well as putative therapeutic targets to regulate the molecular clock.
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Departments of Physiology.
authors.forename: Johanneke E
authors.initials: JE
authors.lastname: Oosterman
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Hypothalamic Integration Mechanisms, The Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;
authors.forename: Susanne E
authors.initials: SE
authors.lastname: la Fleur
authors.affiliation: Departments of Physiology, Obstetrics and Gynaecology and Medicine, University of Toronto and Division of Cellular and Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; and d.belsham@utoronto.ca.
authors.forename: Denise D
authors.initials: DD
authors.lastname: Belsham
mesh_terms: D000818:Animals; D001683:Biological Clocks; D021081:Chronobiology Disorders / Q000378:metabolism / Q000503:physiopathology; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000378:metabolism; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism; D019422:Dietary Sucrose / Q000009:adverse effects / Q000378:metabolism; D004435:Eating; D004734:Energy Metabolism; D005215:Fasting / Q000378:metabolism*; D006801:Humans; D009752:Nutritional Status; D015398:Signal Transduction; D013493:Suprachiasmatic Nucleus / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins; D004041:Dietary Fats; D019422:Dietary Sucrose
keywords: clock genes; glucose; hypothalamus; metabolism; nutrient sensors; saturated fatty acid