title: Highly regio- and enantioselective synthesis of N-substituted 2-pyridones: iridium-catalyzed intermolecular asymmetric allylic amination.
abstract: The first iridium-catalyzed intermolecular asymmetric allylic amination reaction with 2-hydroxypyridines has been developed, thus providing a highly efficient synthesis of enantioenriched N-substituted 2-pyridone derivatives from readily available starting materials. This protocol features a good tolerance of functional groups in both the allylic carbonates and 2-hydroxypyridines, thereby delivering multifunctionalized heterocyclic products with up to 98% yield and 99% ee.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Ze-Peng
authors.initials: ZP
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D000586:Amination; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011728:Pyridones; D007495:Iridium
keywords: allylic compounds; asymmetric catalysis; heterocycles; iridium; synthetic methods