title: Anti-fungal resistance in candida isolated from oral and diaper rash candidiasis in neonates.
abstract: The purpose of the present study is to evaluate the sensitivity of Candida species isolated from oral candidiasis and diaper dermatitis infections in children. The children referring to private and public clinics in Ilam, Iran were exmined for oral candidiasis and diaper dermatitis. In this study, 248 oral candidiasis and diaper dermatitis samples were collected and cultured.Candida species were identified by using standard methods. Resistance and sensitivity to amphotericin B, nystatin, ketoconazole, fluconazole, itraconazole, clotrimazole, and posaconazole were determined using the CLSI M44-A standard disk diffusion method. From the 248 studied samples, 149 were positive for Candida, among which the Candida albicans was the most prevalent (64.4%). The resistance of different Candida species to nystatin, itraconazole, fluconazole, ketoconazole, clotrimazole, voriconazole, and posaconazole were 4, 43, 34.2, 34.9, 21.5, 6, and 6.7%, respectively. No resistance to amphotericin B was observed. Considering rather low resistance to nystatin, this drug is the best choice for oral candidiasis and diaper dermatitis.
authors.affiliation: Department pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Jasem
authors.initials: J
authors.lastname: Mohamadi
authors.affiliation: Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Motaghi
authors.affiliation: Student research of committee, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Panahi
authors.affiliation: Student research of committee, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Havasian
authors.affiliation: Department Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Delpisheh
authors.affiliation: Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Azizian
authors.affiliation: Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran ; Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Pakzad
keywords: Diaper dermatitis; Drug resistance; Oral candidiasis