title: [Impact of end-stage renal disease and kidney transplantation on the reproductive system].
abstract: Chronic renal failure leads to many metabolic disorders affecting reproductive function. For men, hypergonadotropic hypogonadism, hyperprolactinemia, spermatic alterations, decreased libido and erectile dysfunction are described. Kidney transplantation improves sperm parameters and hormonal function within 2 years. But sperm alterations may persist with the use of immunosuppressive drugs. In women, hypothalamic-pituitary-ovarian axis dysfunction due to chronic renal failure results in menstrual irregularities, anovulation and infertility. After kidney transplantation, regular menstruations usually start 1 to 12 months after transplantation. Fertility can be restored but luteal insufficiency can persist. Moreover, 4 to 20% of women with renal transplantation suffer from premature ovarian failure syndrome. In some cases, assisted reproductive technologies can be required and imply risks of ovarian hyperstimulation syndrome and must be performed with caution. Pregnancy risks for mother, fetus and transplant are added to assisted reproductive technologies ones. Only 7 authors have described assisted reproductive technologies for patients with kidney transplantation. No cases of haemodialysis patients have been described yet. So, assisted reproductive technologies management requires a multidisciplinary approach with obstetrics, nephrology and reproductive medicine teams' agreement.
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandres, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. Electronic address: annesophie.delesalle@gmail.com.
authors.forename: A-S
authors.initials: AS
authors.lastname: Delesalle
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandres, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Robin
authors.affiliation: Service de néphrologie, hôpital Claude-Huriez, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Provôt
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandres, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Dewailly
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandres, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Leroy-Billiard
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandres, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Peigné
mesh_terms: D005260:Female; D006058:Gonadal Disorders / Q000209:etiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D027724:Reproductive Techniques, Assisted; D012735:Sexual Dysfunction, Physiological / Q000209:etiology
keywords: Assistance médicale à la procréation; Assisted reproductive technologies; Chronic renal failure; Greffe rénale; Infertility; Infertilité; Insuffisance rénale chronique; Kidney transplantation; Reproduction