title: Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum.
abstract: OBJECTIVE
  T2-hyperintense signal changes in corpus callosum (CC) have been described in epilepsy and encephalitis/encephalopathy. Little is known about their pathophysiology. The aim of this study was to examine the clinical presentation and evolution of CC lesions and relationship to seizures.
  
  
  METHODS
  We identified 12 children among 29,634 patients from Radiology Database. We evaluated following characteristics: seizures and accompanying medical history, antiepileptic drug usage, presenting symptoms, and radiological evolution of lesions.
  
  
  RESULTS
  CC lesions were seen in patients with prior diagnosis of epilepsy (n = 5) or in those with new onset seizures (n = 3), or with encephalitis/encephalopathy without history of seizures (n = 4). Seizure clustering or disturbances of consciousness were the main presenting symptoms. No relationship was observed between CC lesion and AEDs. On imaging, ovoid lesions at presentation resolved on follow up imaging and linear lesions persisted. DTI showed that the fibers passing through splenial lesions originated from the posterior parietal cortex and occipital cortex bilaterally.
  
  
  CONCLUSIONS
  In patients with seizures, no clear relationship was demonstrated between seizure characteristics or AED use with CC lesions. Ovoid lesions resolved and may have different pathophysiologic mechanism when compared to linear lesions that persisted.
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Chellamani
authors.initials: C
authors.lastname: Harini
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.|Department of Neurology, Indiana State University, Indianapolis, IN.
authors.forename: Rohit R
authors.initials: RR
authors.lastname: Das
authors.affiliation: Department of Radiology, Boston Children's Hospital and Harvard Medical School, Harvard Medical School, Boston, MA.
authors.forename: Sanjay P
authors.initials: SP
authors.lastname: Prabhu
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.|Lurie Center, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
authors.forename: Kanwaljit
authors.initials: K
authors.lastname: Singh
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Amit
authors.initials: A
authors.lastname: Haldar
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Masanori
authors.initials: M
authors.lastname: Takeoka
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Bergin
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Tobias
authors.initials: T
authors.lastname: Loddenkemper
authors.affiliation: Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.|New York University Medical Center, Comprehensive Epilepsy Center, Langone Medical School, NY.
authors.forename: Sanjeev V
authors.initials: SV
authors.lastname: Kothare
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012640:Seizures / Q000473:pathology*; D012680:Sensitivity and Specificity
keywords: MRI; Splenial lesions; antiepileptic drugs; corpus callosum; encephalitis; encephalopathy