title: Pretreatment maximum standardized uptake value of (18)F-fluorodeoxyglucose positron emission tomography as a predictor of distant metastasis in adenoid cystic carcinoma of the head and neck.
abstract: BACKGROUND
  The purpose of this study was to determine whether the maximum standardized uptake value (SUVmax) of the primary tumor on pretreatment (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) has prognostic significance in patients with adenoid cystic carcinoma (ACC) of the head and neck.
  
  
  METHODS
  A retrospective review was carried out on 34 patients with ACC of the head and neck who underwent pretreatment (18)F-FDG PET imaging from June 2005 through July 2009. All patients underwent surgery with curative intent, and 26 of them received adjuvant radiotherapy (RT).
  
  
  RESULTS
  When subjects were stratified into 2 groups according to a cutoff value for SUVmax of 4.15, the risk of distant metastasis was significantly high in patients with high SUVmax (p = .014). Multivariate analysis showed that high SUVmax and histologic grade 3 were independent poor prognostic factors for distant metastasis-free and disease-free survival.
  
  
  CONCLUSIONS
  Pretreatment SUVmax of the primary tumor is an independent prognostic factor in patients with ACC of the head and neck.
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Donghyun
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Wontaek
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Joohye
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Yongkan
authors.initials: Y
authors.lastname: Ki
authors.affiliation: Department of Otorhinolaryngology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Byungjoo
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Kyusup
authors.initials: K
authors.lastname: Cho
authors.affiliation: Department of Nuclear Medicine, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Seongjang
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Yangsan Pusan National University Hospital, Yangsan, Korea.
authors.forename: Jiho
authors.initials: J
authors.lastname: Nam
authors.affiliation: Department of Otorhinolaryngology, Yangsan Pusan National University Hospital, Yangsan, Korea.
authors.forename: Jinchoon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging* / Q000401:mortality / Q000556:secondary*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D012372:ROC Curve; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose positron emission tomography (FDG PET); adenoid cystic carcinoma; head and neck cancer; prognosis; standardized uptake value