title: Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery.
abstract: The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses.
authors.affiliation: The Jenner Institute, University of Oxford, Oxford, UK.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pavot
authors.forename: Morgane
authors.initials: M
authors.lastname: Berthet
authors.forename: Julien
authors.initials: J
authors.lastname: Rességuier
authors.forename: Sophie
authors.initials: S
authors.lastname: Legaz
authors.forename: Nadège
authors.initials: N
authors.lastname: Handké
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Gilbert
authors.forename: Stéphane
authors.initials: S
authors.lastname: Paul
authors.forename: Bernard
authors.initials: B
authors.lastname: Verrier
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000627:therapeutic use; D000941:Antigens / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D019344:Lactic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008863:Microspheres; D011091:Polyesters; D011100:Polyglycolic Acid / Q000737:chemistry / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D014612:Vaccines / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D014612:Vaccines; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)
keywords: PLA; PLGA; adjuvants; biodegradable; controlled release; immune response; particles; vaccine delivery