title: One-shot, one cure with genome editing for dyslipidemia.
authors.affiliation: From the Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA. rgupta8@partners.org.
authors.forename: Rajat M
authors.initials: RM
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D044383:Black People / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood*; D018389:Codon, Nonsense; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D008297:Male; D009154:Mutation; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D000911:Antibodies, Monoclonal; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D018389:Codon, Nonsense; D043484:Proprotein Convertases; D012697:Serine Endopeptidases
keywords: PCSK9 protein, human; gene targeting; gene, suppressor; genetic therapy; lipids