title: MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer.
abstract: MicroRNAs (miRNAs) present frequently altered expression in urologic cancers including prostate, bladder, and kidney cancer. The altered expression of miR-223 has been reported in cancers and other diseases in recent researches. MiR-223 is up-regulated in systemic lupus erythematosus and rheumatoid arthritis. In neoplastic diseases, miR-223 is proved to be up-expressed in plasma or serum and cancer tissues compared with normal tissues in pancreatic cancer, gastric cancer, et al. However, whether altered expression of miR-223 is associated with prostate cancer (PCa) and what it is potential functions in PCa remained unveiled. In this study, we firstly found miR-223-3p were up-regulated in prostate cancer tissues and then we study functional role of miR-223-3p in PCa using DU145, PC3 and LNCaP cell lines. Our data suggested that miR-223-3p might target gene SEPT6 and promoted the biological behavior of prostate cancer. Notably, we found increasing SEPT6 expression might reverse the biological activity induced by miR-223-3p, which might be a potential therapeutic target for PCa.
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yongbao
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Jinrui
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yinhuai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Ziting
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Shifeng
authors.initials: S
authors.lastname: Ou-yang
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Urology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D058112:Septins / Q000235:genetics*; D015854:Up-Regulation / Q000235:genetics
chemical_list: D035683:MicroRNAs; D058112:Septins; C525067:MIR223, human; C436485:SEPTIN6 protein, human