title: Association between single-nucleotide polymorphisms and milk production traits in buffalo.
abstract: The aim of this study was to identify single-nucleotide polymorphisms (SNPs) in buffaloes associated with milk yield and content, in addition to somatic cell scores based on the cross-species transferability of SNPs from cattle to buffalo. A total of 15,745 SNPs were analyzed, of which 1562 showed 1% significance and 4742 with 5% significance, which were associated for all traits studied. After application of Bonferroni's correction for multiple tests of the traits analyzed, we found 2 significant SNPs placed on cattle chromosomes BTA15 and BTA20, which are homologous to buffalo chromosomes BBU16 and BBU19, respectively. In this genome association study, we found several significant SNPs affecting buffalo milk production and quality. Furthermore, the use of the high-density bovine BeadChip was suitable for genomic analysis in buffaloes. Although extensive chromosome arm homology was described between cattle and buffalo, the exact chromosomal position of SNP markers associated with these economically important traits in buffalo can be determined only through buffalo genome sequencing.
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil venturinigc@gmail.com.
authors.forename: G C
authors.initials: GC
authors.lastname: Venturini
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: D F
authors.initials: DF
authors.lastname: Cardoso
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: F
authors.initials: F
authors.lastname: Baldi
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: A C
authors.initials: AC
authors.lastname: Freitas
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: R R
authors.initials: RR
authors.lastname: Aspilcueta-Borquis
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: D J A
authors.initials: DJ
authors.lastname: Santos
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: G M F
authors.initials: GM
authors.lastname: Camargo
authors.affiliation: Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista, São José do Rio Preto, SP, Brasil.
authors.forename: N B
authors.initials: NB
authors.lastname: Stafuzza
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: L G
authors.initials: LG
authors.lastname: Albuquerque
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: H
authors.initials: H
authors.lastname: Tonhati
mesh_terms: D000818:Animals; D002020:Buffaloes / Q000235:genetics*; D002417:Cattle; D033481:Chromosomes, Mammalian; D005260:Female; D005819:Genetic Markers; D055106:Genome-Wide Association Study / Q000662:veterinary*; D005838:Genotype; D007774:Lactation; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers