title: Intercellular adhesion molecule-1 K469E polymorphism and risk of coronary artery disease: a meta-analysis.
abstract: BACKGROUND
  Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). Several studies investigated the association of this polymorphism with CAD in different populations but the results were contradictory. A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility.
  
  
  METHODS
  Databases including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.
  
  
  RESULTS
  Fifteen case-control studies including 3088 cases and 3466 controls were included. Overall, a significant association between ICAM-1 K469E polymorphism and CAD was observed in the dominant model (OR=1.80; 95% CI 1.62-2.01; P<0.00001; Pheterogeneity=0.40). In subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.92; 95% CI 1.51-2.43; P<0.00001; Pheterogeneity=0.98) and among Caucasians (OR=1.64; 95% CI 1.30-2.08; P<0.0001; Pheterogeneity=0.04). In the subgroup analysis by age, a significant association was found among young patients (OR=1.46; 95% CI 1.10-1.93; P=0.008; Pheterogeneity=0.21) and old patients (OR=1.92; 95% CI 1.75-2.10; P<0.00001; Pheterogeneity=0.99). Conclusions Results of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD.
authors.affiliation: School of Medicine, Jiangsu University, Zhenjiang, China (mainland).
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Zou
authors.affiliation: Department of Medical Section, Zhenjiang Emergency Medical Center, Zhenjiang, China (mainland).
authors.forename: Xin
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Medical Section, Zhenjiang Emergency Medical Center, Zhenjiang, China (mainland).
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Medical Section, Zhenjiang Emergency Medical Center, Zhenjiang, China (mainland).
authors.forename: Chao
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Medical Section, Zhenjiang Emergency Medical Center, Zhenjiang, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Medical Section, Zhenjiang Emergency Medical Center, Zhenjiang, China (mainland).
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D018799:Intercellular Adhesion Molecule-1