title: NT-3 attenuates the growth of human neuron cells through the ERK pathway.
abstract: Spinal cord injury is a devastating health problem that affects thousands of individuals each year. The neurons were destroyed. NT-3 is a recently discovered neurotrophin. This study sought to understand the potential involvement of MAPKs in NT-3-mediated growth inhibition of human neurons. We applied different concentrations of NT-3 and observed the growth rate of the cells and the changes in the phosphorylation state of the MAPKs ERK1/2, JNK and p38. This study discovered that NT-3-induced HNC growth was promoted primarily by phosphorylated ERK1/2, and that this phosphorylation, as well p90(rsk)phosphorylation, was mediated by TrkC. The ERK1/2 pathway is known to play an essential role in the NT-3-mediated growth of human neurons. In conclusion, our study suggests that NT-3 promotes the growth of human neurons cells primarily through the TrkC/ERK pathway.
authors.affiliation: Department of Orthopedic, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District Yueyuan Road No1, Chongqing, China.|Department of Cervical Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University, Muslims camp Square Road No 1, Hohhot, China.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Cervical Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University, Muslims camp Square Road No 1, Hohhot, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Orthopedic, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District Yueyuan Road No1, Chongqing, China. jiangdianming1122@126.com.
authors.forename: Dianming
authors.initials: D
authors.lastname: Jiang
keywords: Growth; HNC; MAPKs; NT-3