title: Does pulmonary resection promote the progression of unresected ground-glass nodules?
abstract: BACKGROUND
  The routine use of thin-section, whole-lung computed tomographic scanning helps detect persistent ground-glass nodules (GGNs) co-existing with the target lesion in the underlying lung.
  
  
  METHODS
  The cases of 10 patients with persistent co-existing GGNs detected on whole-lung computed tomography performed prior to surgery for lung cancer were retrospectively reviewed. The co-existing lesions were not resected at the initial procedure.
  
  
  RESULTS
  Although no masses exhibited progression during the 15.5-month preoperative follow-up period, all lesions displayed enlargement during the first year after the initial procedure, with the exception of one tumor. Three lesions arose in the ipsilateral lung, while the remaining lesions arose in the contralateral lung. The nine enlarged lesions were diagnosed as adenocarcinoma on subsequent resection.
  
  
  CONCLUSIONS
  Lung adenocarcinoma with persistent GGNs tends to progress after lung resection for other lesions. This phenomenon should be kept in mind when selecting for surgical procedure in patients with persistent co-existing GGNs.
authors.affiliation: Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan kaueda@c-able.ne.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Fumiho
authors.initials: F
authors.lastname: Sano
authors.affiliation: Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Murakami
authors.affiliation: Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Masataro
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Department of Radiopathology and Science, Division of Radiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Taiga
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Radiopathology and Science, Division of Radiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Kunihiro
authors.affiliation: Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Hamano
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000601:surgery*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*
keywords: Ground-glass nodule; lung cancer; pulmonary resection