title: A model-based analysis of a simplified beam-specific dose output in proton therapy with a single-ring wobbling system.
abstract: In radiation therapy, it is necessary to preset a monitor unit in an irradiation control system to deliver a prescribed absolute dose to a reference point in the planning target volume. The purpose of this study was to develop a model-based monitor unit calculation method for proton-beam therapy with a single-ring wobbling system. The absorbed dose at a calibration point per monitor unit had been measured for each beam-specific measurement condition without a patient-specific collimator or range compensator before proton therapeutic irradiation at Shizuoka Cancer Center. In this paper, we propose a simplified dose output model to obtain the output ratio between a beam-specific dose and a reference field dose, from which a monitor unit for the proton treatment could be derived without beam-specific measurements. The model parameters were determined to fit some typical data measured in a proton treatment room, called a Gantry 1 course. Then, the model calculation was compared with 5456 dose output ratios that had been measured for 150-, 190- and 220 MeV therapeutic proton beams in two treatment rooms over the past decade. The mean value and standard deviation of the difference between the measurement and the model calculation were respectively 0.00% and 0.27% for the Gantry 1 course, and -0.25% and 0.35% for the Gantry 2 course. The model calculation was in good agreement with the measured beam-specific doses, within 1%, except for conditions less frequently used for treatment. The small variation for the various beam conditions shows the high long-term reproducibility of the measurement and high degree of compatibility of the two treatment rooms. Therefore, the model was expected to assure the setting value of the dose monitor for treatment, to save the effort required for beam-specific measurement, and to predict the dose output for new beam conditions in the future.
authors.affiliation: Proton Therapy Division, Shizuoka Cancer Center Hospital, 1007, Shimonagakubo, Nagaizumi-cho, Shizuoka 411-8777, Japan. Proton Therapy Division, Shizuoka Cancer Center Research Institute, 1007, Shimonagakubo, Nagaizumi-cho, Shizuoka 411-8777, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kase
authors.forename: Haruo
authors.initials: H
authors.lastname: Yamashita
authors.forename: Masumi
authors.initials: M
authors.lastname: Numano
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakama
authors.forename: Manabu
authors.initials: M
authors.lastname: Mizota
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tameshige
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murayama
mesh_terms: D000465:Algorithms; D002138:Calibration; D006801:Humans; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D061766:Proton Therapy / Q000295:instrumentation*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D012542:Scattering, Radiation