title: Kruppel-like factors in muscle health and disease.
abstract: Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.
authors.affiliation: Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
authors.forename: Domenick A
authors.initials: DA
authors.lastname: Prosdocimo
authors.affiliation: Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
authors.forename: M Khaled
authors.initials: MK
authors.lastname: Sabeh
authors.affiliation: Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH. Electronic address: mukesh.jain2@case.edu.
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Jain
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D051741:Kruppel-Like Transcription Factors