title: Luteal Phase Support in the Intrauterine Insemination (IUI) Cycles: A Randomized Double Blind, Placebo Controlled Study.
abstract: OBJECTIVE
  To evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (IUI) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hMG), in sub fertile couples.
  
  
  METHODS
  This prospective, randomized, double blind study was performed in a tertiary infertility center from March 2011 to January 2012. It consisted of 253 sub fertile couples undergoing ovarian stimulation for IUI cycles. They underwent ovarian stimulation with clomiphene citrate (100 mg) and hMG (75 IU) in preparation for the IUI cycle. Study group (n = 127) received luteal phase support in the form of vaginal progesterone (400 mg twice a day), and control group (n = 126) received placebo. Clinical pregnancy and abortion rates were assessed and compared between the two groups.
  
  
  RESULTS
  The clinical pregnancy rate was not significantly higher for supported cycles than that for the unsupported ones (15.75% vs. 12.69%, p = 0.3). The abortion rate in the patients with progesterone luteal support compared to placebo group was not statistically different (10% vs. 18.75%, p = 0.45).
  
  
  CONCLUSIONS
  It seems that luteal phase support with vaginal progesterone was not enhanced the success of IUI cycles outcomes, when clomiphene citrate and hMG were used for ovulation stimulation.
authors.affiliation: Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Batool
authors.initials: B
authors.lastname: Hossein Rashidi
authors.affiliation: Zanan Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Davari Tanha
authors.affiliation: Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Haleh
authors.initials: H
authors.lastname: Rahmanpour
authors.affiliation: Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahya
authors.initials: M
authors.lastname: Ghazizadeh
keywords: IUI; clomiphene citrate; hMG; luteal phase support; progesterone