title: The choroid plexus and the paradox of interferons in the aging brain.
abstract: The choroid plexus (CP) function is largely viewed as the source of cerebrospinal fluid (CSF) and as a barrier between the blood and the CSF. Other functions of the CP are becoming increasingly recognized as in the recent publication by Baruch et. al. who demonstrate increased expression of interferon type I mRNA signature (irf7, ifnß and ifit1) in CP of aged brains compared to younger brains, whereas interferon type II dependent genes (icam1, cxcl10, and ccl17) are reduced in the aging CP. The authors speculate an IFN-dependent mechanism that plays a role in the aging process and cognitive decline. This short communication summarizes the findings by the authors and highlights the seemingly paradoxical roles of IFN type I and type II in neuroinflammation.
authors.affiliation: Department of Neurology, RUTGERS-Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901, United States. Electronic address: jalbutsu@rutgers.edu.
authors.forename: Suhayl
authors.initials: S
authors.lastname: Dhib-Jalbut
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D054414:Chemokine CCL17 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D002831:Choroid Plexus / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D050839:Interferon Regulatory Factor-7 / Q000378:metabolism; D016899:Interferon-beta / Q000378:metabolism; D007372:Interferons / Q000378:metabolism*; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000473:pathology; D016601:RNA-Binding Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D054414:Chemokine CCL17; D054357:Chemokine CXCL10; C092573:Ifit1 protein, mouse; D050839:Interferon Regulatory Factor-7; D016601:RNA-Binding Proteins; D018799:Intercellular Adhesion Molecule-1; D016899:Interferon-beta; D007372:Interferons
keywords: Aging; Choroid plexus; Interferon; Neurogenesis; Neuroinflammation