title: Improved nutrient intake following implementation of the consensus standardised parenteral nutrition formulations in preterm neonates--a before-after intervention study.
abstract: BACKGROUND
  New standardised parenteral nutrition (SPN) formulations were implemented in July 2011 in many neonatal intensive care units in New South Wales following consensus group recommendations. The aim was to evaluate the efficacy and safety profile of new consensus formulations in preterm infants born less than 32 weeks.
  
  
  METHODS
  A before-after intervention study conducted at a tertiary neonatal intensive care unit. Data from the post-consensus cohort (2011 to 2012) were prospectively collected and compared retrospectively with a pre-consensus cohort of neonates (2010).
  
  
  RESULTS
  Post-consensus group commenced parenteral nutrition (PN) significantly earlier (6 v 11 hours of age, p 0.005). In comparison to the pre-consensus cohort, there was a higher protein intake from day 1 (1.34 v 0.49 g/kg, p 0.000) to day 7 (3.55 v 2.35 g/kg, p 0.000), higher caloric intake from day 1 (30 v 26 kcal/kg, p 0.004) to day 3 (64 v 62 kcal/kg, p 0.026), and less daily fluid intake from day 3 (105.8 v 113.8 mL/kg, p 0.011) to day 7 (148.8 v 156.2 mL/kg, p 0.025), and reduced duration of lipid therapy (253 v 475 hr, p 0.011). This group also had a significantly greater weight gain in the first 4 weeks (285 v 220 g, p 0.003).
  
  
  CONCLUSIONS
  New consensus SPN solutions provided better protein intake in the first 7 days and were associated with greater weight gain in the first 4 weeks. However, protein intake on day 1 was below the consensus goal of 2 g/kg/day.
authors.affiliation: Division of Newborn Services, Royal Hospital for Women, Sydney, Australia. Srinivas.bolisetty@sesiahs.health.nsw.gov.au.|University of New South Wales, Sydney, Australia. Srinivas.bolisetty@sesiahs.health.nsw.gov.au.|Division of Newborn Services, Royal Hospital for Women, Barker Street, Locked Bag 2000, Randwick, 2031, NSW, Australia. Srinivas.bolisetty@sesiahs.health.nsw.gov.au.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Bolisetty
authors.affiliation: Division of Newborn Services, Royal Hospital for Women, Sydney, Australia. drpramodpharande@gmail.com.|University of New South Wales, Sydney, Australia. drpramodpharande@gmail.com.
authors.forename: Pramod
authors.initials: P
authors.lastname: Pharande
authors.affiliation: University of New South Wales, Sydney, Australia. lakshman.nirthanakumaran@gmail.com.
authors.forename: Lakshman
authors.initials: L
authors.lastname: Nirthanakumaran
authors.affiliation: University of New South Wales, Sydney, Australia. do.timothy@gmail.com.
authors.forename: Timothy Quy-Phong
authors.initials: TQ
authors.lastname: Do
authors.affiliation: University of Sydney and RPA Newborn Care, Royal Prince Alfred Hospital, Sydney, Australia. david.osborn@sydney.edu.au.
authors.forename: David
authors.initials: D
authors.lastname: Osborn
authors.affiliation: Division of Newborn Services, Royal Hospital for Women, Sydney, Australia. john.smyth@sesiahs.health.nsw.gov.au.|University of New South Wales, Sydney, Australia. john.smyth@sesiahs.health.nsw.gov.au.
authors.forename: John
authors.initials: J
authors.lastname: Smyth
authors.affiliation: Department of Neonatology, Royal North Shore Hospital, University of Sydney and, Sydney, Australia. John.sinn@health.nsw.gov.au.
authors.forename: John
authors.initials: J
authors.lastname: Sinn
authors.affiliation: Division of Newborn Services, Royal Hospital for Women, Sydney, Australia. kei.lui@sesiahs.health.nsw.gov.au.|University of New South Wales, Sydney, Australia. kei.lui@sesiahs.health.nsw.gov.au.
authors.forename: Kei
authors.initials: K
authors.lastname: Lui
mesh_terms: D006801:Humans; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D019983:Guideline Adherence; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D009517:New South Wales; D010288:Parenteral Nutrition; D011446:Prospective Studies; D012189:Retrospective Studies; D015430:Weight Gain; D003245:Consensus Statements as Topic
chemical_list: D004044:Dietary Proteins