title: Epithelial ovarian cancer: An overview.
abstract: Ovarian cancer is the second most common gynecological cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions.
authors.affiliation: Department of Internal Medicine, University of Buffalo, Erie County Medical Center, Buffalo, NY 14215, United States.
authors.forename: Arpita
authors.initials: A
authors.lastname: Desai
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Jingyao
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Kartik
authors.initials: K
authors.lastname: Aysola
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Chika
authors.initials: C
authors.lastname: Okoli
authors.affiliation: Department of Internal Medicine, Morehouse School of Medicine, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Ravipati
authors.initials: R
authors.lastname: Hariprasad
authors.affiliation: Department of Internal Medicine, Morehouse School of Medicine, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Ugorji
authors.initials: U
authors.lastname: Chinemerem
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Candace
authors.initials: C
authors.lastname: Gates
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Avinash
authors.initials: A
authors.lastname: Reddy
authors.affiliation: Department of Surgery, Morehouse School of Medicine, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Omar
authors.initials: O
authors.lastname: Danner
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Geary
authors.initials: G
authors.lastname: Franklin
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Anachebe
authors.initials: A
authors.lastname: Ngozi
authors.affiliation: NCI Cancer Program, Northside Hospital, Atlanta, GA 30342, United States.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Cantuaria
authors.affiliation: University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham AL 35294, United States.
authors.forename: Karan
authors.initials: K
authors.lastname: Singh
authors.affiliation: University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham AL 35294, United States.
authors.forename: William
authors.initials: W
authors.lastname: Grizzle
authors.affiliation: University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham AL 35294, United States.
authors.forename: Charles
authors.initials: C
authors.lastname: Landen
authors.affiliation: University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham AL 35294, United States.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Partridge
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Valerie Montgomery
authors.initials: VM
authors.lastname: Rice
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: E Shyam P
authors.initials: ES
authors.lastname: Reddy
authors.affiliation: Department of OB/GYN, Cancer Biology Program, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, United States.
authors.forename: Veena N
authors.initials: VN
authors.lastname: Rao
keywords: Breast cancer type 1; Chemotherapy; Epithelial ovarian cancer