title: Yaws.
abstract: BACKGROUND
  Yaws, caused by Treponema pallidum ssp. pertenue, is endemic in parts of West Africa, Southeast Asia and the Pacific. The WHO has launched a campaign based on mass treatment with azithromycin, to eradicate yaws by 2020.
  
  
  METHODS
  We reviewed published data, surveillance data and data presented at yaws eradication meetings.
  
  
  RESULTS
  Azithromycin is now the preferred agent for treating yaws. Point-of-care tests have demonstrated their value in yaws.
  
  
  RESULTS
  There is limited data from 76 countries, which previously reported yaws. Different doses of azithromycin are used in community mass treatment for yaws and trachoma.
  
  
  CONCLUSIONS
  Yaws eradication appears an achievable goal. The programme will require considerable support from partners across health and development sectors.
  
  
  CONCLUSIONS
  Studies to complete baseline mapping, integrate diagnostic tests into surveillance and assess the impact of community mass treatment with azithromycin are ongoing.
authors.affiliation: Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, Mortimer Market, London WC1E 6JB, UK michael.marks@lshtm.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Marks
authors.affiliation: Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Roselló 132, Barcelona, Spain Lihir Medical Centre-International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
authors.forename: Oriol
authors.initials: O
authors.lastname: Mitjà
authors.affiliation: Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, Mortimer Market, London WC1E 6JB, UK Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Solomon
authors.affiliation: Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.
authors.forename: Kingsley B
authors.initials: KB
authors.lastname: Asiedu
authors.affiliation: Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, Mortimer Market, London WC1E 6JB, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Mabey
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000191:economics; D017963:Azithromycin / Q000008:administration & dosage* / Q000191:economics; D003362:Cost-Benefit Analysis; D060740:Disease Eradication / Q000191:economics / Q000379:methods; D006801:Humans; D016730:Program Development; D018571:Sentinel Surveillance; D014210:Treponema pallidum / Q000187:drug effects*; D015001:Yaws / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin
keywords: eradication; neglected tropical diseases; syphilis; yaws