title: [Regulation of the O-antigen polysaccharide chain length by Wzz- a review ].
abstract: The O-antigen of Gram-negative bacterium plays an important role in the signal identification, adhesion, immune evasion and other processes. There are three O-antigen polysaccharides biosynthesis mechanisms according to the type of the flippase that is involved. The Wzy-dependent mechanism is more commonly seen. In Wzy-dependent mechanism, the wzz gene is involved in regulating the length of O-antigen polysaccharide chain which can affect antigenicity of the pathogen and immune response of the host. Based on the crystal structure of Wzz (regulator of the O- antigen polysaccharides length) , different length of O-antigen chain can be obtained through molecular modification of the gene wzz. Conjugating O-antigen or its mutants of a pathogen to a carrier protein could help to develop a vaccine that have both a good target specificity and a strong immunogenicity. Therefore, it is important to understand the function, structure and mechanism of Wzz for the development and production of glycoconjugates vaccine.
authors.forename: Donglei
authors.initials: D
authors.lastname: Han
authors.forename: Zhongrui
authors.initials: Z
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Chen
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001424:Bacterial Infections / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019081:O Antigens / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D019081:O Antigens; C075969:rol protein, Bacteria