title: 4-Vinylcyclohexene diepoxide reduces fertility in female Siberian hamsters when treated during their reproductively active and quiescent states.
abstract: The industrial compound 4-vinylcyclohexene diepoxide (VCD) destroys ovarian follicles and reduces fertility in rodents, but to date VCD has not been tested in species that experience seasonal anestrus. To determine if VCD destroys follicles when administered during reproductive quiescence, Siberian hamsters were treated with VCD (240mg/kg i.p. daily for 10 days) during short days, and outcomes were compared with reproductively active females that were maintained and treated in long days. Primordial follicle numbers were significantly reduced by VCD under both day lengths, and reproductive quiescence in short days did not appear to render the ovaries less susceptible to VCD-induced follicle depletion. Independent of day length and reproductive state, VCD-treated hamsters weaned substantially fewer offspring than controls. These results suggest that time of year may not be an important consideration for optimizing use of VCD in the field when the target pest species is a seasonally breeding rodent.
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: Kar277@cornell.edu.
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Roosa
authors.affiliation: Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Motoko
authors.initials: M
authors.lastname: Mukai
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Ned J
authors.initials: NJ
authors.lastname: Place
mesh_terms: D000818:Animals; D006224:Cricetinae; D053138:Cyclohexenes / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D010053:Ovary / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects; D017440:Photoperiod; D012098:Reproduction / Q000502:physiology*; D014753:Vinyl Compounds / Q000633:toxicity*
chemical_list: D053138:Cyclohexenes; D014753:Vinyl Compounds; C012606:4-vinyl-1-cyclohexene dioxide
keywords: 4-Vinylcyclohexene diepoxide; Fertility control; Ovary; Photoperiod