title: Vitamin E intake is not associated with glioma risk: evidence from a meta-analysis.
abstract: BACKGROUND
  Epidemiological studies evaluating the association between vitamin E intake and glioma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin E intake with the risk of glioma.
  
  
  METHODS
  Pertinent studies were identified by a search in pubmed and web of knowledge up to August 2014. The random-effect model was used to combine the results. Publication bias was estimated using the Egger's regression asymmetry test.
  
  
  RESULTS
  Twelve studies including 3180 glioma cases about vitamin E intake with the risk of glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with vitamin E intake was 0.88 (95% CI = 0.69-1.12). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found.
  
  
  CONCLUSIONS
  Our analysis indicated that vitamin E intake is not associated with the risk of glioma.
authors.affiliation: Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Qin
authors.forename: Minghai
authors.initials: M
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Shuguang
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D002675:Child, Preschool; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D005910:Glioma / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D014810:Vitamin E