title: Expression and prognostic value of Mycl1 in gastric cancer.
abstract: As a member of the Myc proto-oncogene family, MYCL1 has been found to be amplified and overexpressed in some malignancies. However, the clinical significance of Mycl1 expression in gastric cancer is still unknown. Mycl1 expression was detected on tissue microarrays of gastric cancer samples in 176 cases using immunohistochemical staining, and its association with clinicopathological factors and overall survival was also analyzed. Mycl1 showed greater expression in gastric cancer tissue than in adjacent normal tissue (62.5% vs 46.0%, respectively, P=0.002), and its expression was correlated with patient age, tumor differentiation, and TNM stage (P=0.007, 0.003, and 0.002, respectively). The Mycl1 positive group had an unfavorable outcome compared with the negative group (P<0.001). Multivariate analysis showed that Mycl1 expression was an independent prognostic factor of gastric cancer (P=0.009). These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer.
authors.affiliation: Department of Pathology, Pre-Clinical College, Fujian Medical University, Fuzhou 350004, China. Electronic address: chshqin2@163.com.
authors.forename: Shuqin
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Pathology, The Affiliated First Hospital, Fujian Medical University, Fuzhou 350004, China. Electronic address: jianqing_Tang1@163.com.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Pathology, Pre-Clinical College, Fujian Medical University, Fuzhou 350004, China. Electronic address: Liyun_Huang1@163.com.
authors.forename: Liyun
authors.initials: L
authors.lastname: Huang
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Research Center of Molecular Medicine, Fujian Medical University, 88 Jiaotong Road, Fuzhou 350004, China. Electronic address: jianyin_lin1@163.com.
authors.forename: Jianyin
authors.initials: J
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C000715470:MAS1 protein, human; C000596782:MYCL protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc
keywords: Biomarker; Gastric cancer; Mycl1; Prognostic factor