title: Impact of anti-peroxynitrite-damaged-thymidine-monophosphate antibodies on disease activity in patients with systemic lupus erythematosus.
abstract: Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (SLEDAI). Serum analysis showed significant increased number of subjects positive for anti-ONOO(-)-TMP-protein antibodies in SLE patients with different SLEDAI scores. Interestingly, the levels of these antibodies were significantly higher among SLE patients, whose SLEDAI scores were ≥20. In addition, a significant correlation was observed between the levels of anti-ONOO(-)-TMP-protein antibodies and the SLEDAI score (r = 0.595, p < 0.0001). In short, this study shows a positive association between anti-ONOO(-)-TMP-protein antibodies and SLEDAI. The stronger response observed in patients with higher SLEDAI scores suggests that anti-ONOO(-)-TMP-protein antibodies may be useful in evaluating the progression of SLE and in elucidating the mechanisms of disease pathogenesis.
authors.affiliation: a Department of Pharmacology and Therapeutics, College of Medicine , Qassim University , Buraidah , KSA.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alghasham
authors.forename: Abdulaziz A M
authors.initials: AA
authors.lastname: Al Salloom
authors.forename: Ahmed S S
authors.initials: AS
authors.lastname: Alghamadi
authors.forename: Zafar
authors.initials: Z
authors.lastname: Rasheed
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D030421:Peroxynitrous Acid / Q000737:chemistry*; D013938:Thymidine Monophosphate / Q000737:chemistry / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D030421:Peroxynitrous Acid; D013938:Thymidine Monophosphate
keywords: SLE; SLEDAI; anti-ONOO--TMP-protein antibodies; peroxynitrite; thymidine monophosphate