title: The Effects of One-Stage Full-Mouth Disinfection and Qua-drant-Wise Scaling and Root Planing on Serum Levels of IL-17 and IL-1β and Clinical Parameters (A randomized Controlled Trial Study).
abstract: OBJECTIVE
  One-stage full-mouth disinfection technique (FMD) has been introduced to avoid cross-contamination between the treated and untreated regions between treatment sessions. Considering the role of inflammatory mediators in periodontitis, the aim of the present study was to compare the effects of FMD with the quadrant-wise scaling and root planing (Q-SRP) on serum levels of IL-17 and IL-1β in patients with moderate-to-severe chronic periodontitis.
  
  
  METHODS
  Twenty patients with chronic periodontitis were selected randomly and based on inclusion criteria in each group. In order to evaluate the periodontal status, the clinical parameters of bleeding on probing (BOP), clinical attachment level (CAL), probing depth (PD) and modified gingival index (MGI) were measured and recorded before treatment and at 2- and 4-month intervals after treatment. Immunologic parameters of the study such as IL-17 and IL-1β serum levels were determined by special laboratory kits at the same intervals. Data were analyzed by SPSS 15 statistical software. Statistical significance was defined at p<0.05.
  
  
  RESULTS
  The results showed a decrease in the means of IL-17 and IL-1β serum levels in both treatment modalities, with no statistically significant differences between the two study groups at the two time intervals (p>0.05). In the evaluation of periodontal parameters, all parameters exhibited clinical improvements in both groups, with no statistically significant differences between the two study groups (p>0.05).
  
  
  CONCLUSIONS
  Based on the results of the present study it was concluded that both FMD and Q-SRP techniques result in improvements in periodontal indexes and decreases in the serum levels of IL-17 and IL-1β inflammatory mediators.
authors.affiliation: Associated Professor, Dental and Periodontal Research center, Department of Periodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Adileh
authors.initials: A
authors.lastname: Shirmohammadi
authors.affiliation: Assistant Professor, Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Babaloo
authors.affiliation: Assistant Professor, Department of Peiodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Eskandari
authors.affiliation: Professor, Department of Peiodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Purabbas
authors.affiliation: Assistant Professor, Department of Periodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Amirreza
authors.initials: A
authors.lastname: Babaloo
keywords: Chronic Periodontitis; Disinfection; Dental Scaling/methods; Interleukin 17; Interleukin 1βeta