title: PTP1B inhibitory effect of alkyl p-coumarates from Calystegia soldanella.
abstract: In this report, the PTP1B inhibitory effect of Calystegia soldanella was investigated. Bioassay-guided fractionation of the crude extracts revealed that the n-hexane fraction had the strongest PTP1B inhibitory effect. Nine known alkyl p-coumarates were isolated from the n-hexane fraction, and each compound was evaluated for its effect on PTP1B. All compounds effectively inhibited PTP1B activity. The IC50 values of the compounds were 3 (10.8 μg/mL) > 2 (15.5 μg/mL) > 7 (26.6 μg/mL) > 1 (37.0 μg/mL) > 8 (41.2 μg/mL) > 9 (43.4 μg/mL) > 5 (44.7 μg/mL) > 4 (> 50 μg/mL) > 6 (> 50 μg/mL).
authors.forename: Jung Im
authors.initials: JI
authors.lastname: Lee
authors.forename: In-Hye
authors.initials: IH
authors.lastname: Kim
authors.forename: Youn Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Taek-Jeong
authors.initials: TJ
authors.lastname: Nam
mesh_terms: D000818:Animals; D031253:Calystegia / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006586:Hexanes / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D006586:Hexanes; C026385:n-hexane; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1