title: Facile, protection-free, one-pot synthesis of aureusidin.
abstract: A new, reliable, and convenient protection-free one-pot method for the synthesis of aureusidin (1) is described. The present synthetic approach involves the condensation of 4,6-dihydroxybenzofuranone with 3,4-dihydroxybenzaldehyde in the presence of concentrated HCl to afford aureusidin (1) in good yield with high purity. This procedure offers a short and simple route for the preparation of aureusidin (1), a bioactive natural product from several vegetal species, as well as for synthesis of other aurones.
authors.forename: Quoc Vuong
authors.initials: QV
authors.lastname: Nguyen
authors.forename: Phuong Diep Thi
authors.initials: PD
authors.lastname: Lan
authors.forename: Hang Pham
authors.initials: HP
authors.lastname: Thi
authors.forename: Van Chien
authors.initials: VC
authors.lastname: Vu
authors.forename: Tuan Nguyen
authors.initials: TN
authors.lastname: Le
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001547:Benzaldehydes; D001572:Benzofurans; D002396:Catechols; C486837:aurone; C416232:aureusidin; C005581:protocatechualdehyde