title: Alterations in skin temperature and sleep in the fear of harm phenotype of pediatric bipolar disorder.
abstract: In children diagnosed with pediatric bipolar disorder (PBD), disturbances in the quality of sleep and wakefulness are prominent. A novel phenotype of PBD called Fear of Harm (FOH) associated with separation anxiety and aggressive obsessions is associated with sleep onset insomnia, parasomnias (nightmares, night-terrors, enuresis), REM sleep-related problems, and morning sleep inertia. Children with FOH often experience thermal discomfort (e.g. feeling hot, excessive sweating) in neutral ambient temperature conditions, as well as no discomfort during exposure to the extreme cold, and alternate noticeably between being excessively hot in the evening and cold in the morning. We hypothesized that these sleep- and temperature-related symptoms were overt symptoms of an impaired ability to dissipate heat, particularly in the evening hours near the time of sleep onset. We measured sleep/wake variables using actigraphy, and nocturnal skin temperature variables using thermal patches and a wireless device, and compared these data between children with PBD/FOH and a control sample of healthy children. The results are suggestive of a thermoregulatory dysfunction that is associated with sleep onset difficulties. Further, they are consistent with our hypothesis that alterations in neural circuitry common to thermoregulation and emotion regulation underlie affective and behavioral symptoms of the FOH phenotype.
authors.affiliation: Parallax Innovations LLC, 22 Crescent Rd. Westport, CT 06880.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Murphy
authors.affiliation: Parallax Innovations LLC, 22 Crescent Rd. Westport, CT 06880.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Frei
authors.affiliation: Parallax Innovations LLC, 22 Crescent Rd. Westport, CT 06880 ; Director of Research, The Juvenile Bipolar Research Foundation, 277 Martine Avenue, White Plains NY 10601.
authors.forename: Demitri
authors.initials: D
authors.lastname: Papolos
keywords: Fear of Harm; actigraphy; distal-proximal temperature gradient; parasomnias; pediatric bipolar disorder; phenotype; sleep diary; sleep disturbance; sleep-onset latency; thermoregulatory deficit