title: Evaluation of suspected soft tissue lesion in the prostate bed after radical prostatectomy using 3T multiparametric magnetic resonance imaging.
abstract: OBJECTIVE
  To investigate the usefulness of multiparametric MR imaging (mp-MRI) at 3T for evaluating suspected soft tissue lesion in the prostate bed after radical prostatectomy (RP).
  
  
  METHODS
  Forty-three patients with biochemical recurrence (BCR) who received RP underwent mp-MRI at 3T with a phased-array coil, including T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCE-MRI) and were enrolled in this study. All patients with BCR had a suspected soft tissue lesion in the prostate bed, followed by transrectal ultrasound-guided biopsy. As a control group, 14 consecutive patients without BCR who received RP were also enrolled. Two experienced radiologists independently analyzed four different imaging datasets.
  
  
  RESULTS
  For predicting local recurrence, the specificity, accuracy and area under the curve for both readers were significantly greater on all combined imaging datasets than on T2WI alone (P<0.05). The sensitivity of all combined imaging datasets in both readers was not statistically different with T2WI alone (P>0.05), except for combined T2WI and DWI. Inter-reader agreements for the four different imaging datasets were moderate.
  
  
  CONCLUSIONS
  DCE-MRI or DWI in combination with T2WI at 3T with a phased-array coil appears to be more useful than T2WI alone in evaluating suspected soft tissue lesion of the prostate bed after RP.
authors.affiliation: Department of Radiology and Centre for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Dongik
authors.initials: D
authors.lastname: Cha
authors.affiliation: Department of Radiology and Centre for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: chankyokim@skku.edu.
authors.forename: Chan Kyo
authors.initials: CK
authors.lastname: Kim
authors.affiliation: Department of Radiology and Centre for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sung Yoon
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Radiology and Centre for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Radiology and Centre for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Byung Kwan
authors.initials: BK
authors.lastname: Park
mesh_terms: D000368:Aged; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000517:prevention & control*; D018365:Neoplasm, Residual; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
keywords: Local neoplasm recurrence; Magnetic resonance imaging; Multiparametric MRI; Prostate cancer; Prostatectomy