title: Genetic polymorphisms of interleukin-1 alpha and the vitamin d receptor in mexican mestizo patients with intervertebral disc degeneration.
abstract: Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD (n = 100) and subjects with normal lumbar-spine MRI-scans (n = 100). Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% (P = 0.455) for T of rs1800587 (IL1A); 53.0% versus 58.0% (P = 0.183) for V of rs2228570 (VDR); and 18.0% versus 21.0% (P = 0.262) for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.
authors.affiliation: Division of Pain, ISSSTE Hospital, 80200 Culiacán, SIN, Mexico.
authors.forename: Salvador
authors.initials: S
authors.lastname: Cervin Serrano
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Dalia
authors.initials: D
authors.lastname: González Villareal
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Maribel
authors.initials: M
authors.lastname: Aguilar-Medina
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Jose Guillermo
authors.initials: JG
authors.lastname: Romero-Navarro
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Jose Geovanni
authors.initials: JG
authors.lastname: Romero Quintana
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Eliakym
authors.initials: E
authors.lastname: Arámbula Meraz
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Osuna Ramírez
authors.affiliation: Human Genetics Laboratory of the Research Unit, Faculty of Medicine, Autonomous University of Sinaloa, 80019 Culiacán, SIN, Mexico.
authors.forename: Veronica
authors.initials: V
authors.lastname: Picos-Cárdenas
authors.affiliation: Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, 14000 Mexico City, DF, Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.affiliation: Department of Immunology, National School of Biological Science, National Polytechnic Institute, 11340 Mexico City, DF, Mexico.
authors.forename: Iris
authors.initials: I
authors.lastname: Estrada-García
authors.affiliation: Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USA.
authors.forename: Guzman
authors.initials: G
authors.lastname: Sánchez-Schmitz
authors.affiliation: Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico ; Laboratory of Immunology, Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Avenida de las Américas y Universitarios s/n, Ciudad Universitaria, 80010 Culiacán, SIN, Mexico.
authors.forename: Rosalío
authors.initials: R
authors.lastname: Ramos-Payán