title: Antibacterial activity of novel benzopolycyclic amines.
abstract: Staphylococcus aureus, especially strains resistant to multiple antibiotics, is a major pathogen for humans and animals. In this paper we have synthesized and evaluated the antibacterial activity of a new series of benzopolycyclic amines. Some of them exhibited μM MIC values against Staphylococcus aureus and other bacteria, including methicillin-resistant S. aureus MRSA. Compound 8 that displayed a good selectivity index, showed to be active in eliminating bacterial cells forming a preexisting biofilm.
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona E-08028, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Barniol-Xicota
authors.affiliation: Bacterial Infections and Antimicrobial Therapies, Institute for Bioengineering of Catalonia, Baldiri Reixac 15-21, 08028 Barcelona, Spain.
authors.forename: Alex
authors.initials: A
authors.lastname: Escandell
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona E-08028, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Valverde
authors.affiliation: Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Facultat de Biociències, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Julián
authors.affiliation: Bacterial Infections and Antimicrobial Therapies, Institute for Bioengineering of Catalonia, Baldiri Reixac 15-21, 08028 Barcelona, Spain. Electronic address: etorrents@ibecbarcelona.eu.
authors.forename: Eduard
authors.initials: E
authors.lastname: Torrents
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona E-08028, Spain. Electronic address: svazquez@ub.edu.
authors.forename: Santiago
authors.initials: S
authors.lastname: Vázquez
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents
keywords: Antibacterials; Minimal biofilm inhibitory concentration; Polycyclic compounds; Staphylococcus aureus