title: Comparison of renal function indicators according to hydration volume in patients receiving intravenous acyclovir with CNS infection.
abstract: OBJECTIVE
  We aimed to compare the changes in renal function indicators as a function of hydration volume in patients treated with acyclovir for suspected herpes simplex virus (HSV) infection.
  
  
  METHODS
  We obtained data from 216 acyclovir-treated patients hospitalized between 2007 and 2012 for suspected HSV infection. Intravenous hydration volume and renal function indicators (serum creatinine [sCr], blood urea nitrogen [BUN], glutamate oxaloacetate transferase, glutamate pyruvate transferase, and uric acid levels; estimated glomerular filtration rate [eGFR]; and urine pH) were compared among the patients. The indicators were assessed before acyclovir infusion and after 3 days of acyclovir infusion.
  
  
  RESULTS
  Before acyclovir infusion, all the indicators were within normal ranges in all groups (hydration volume lower than 2 L/day, higher than 2 L/day, and without hydration). After acyclovir infusion for 3 days, the groups without hydration and with a volume lower than 2 L/day showed increased sCr (2.22 ± 0.51 and 1.70 ± 0.35 mg/dl, respectively), BUN levels (28.33 ± 0.57 and 22.14 ± 7.95 mg/dl, respectively), and glutamate oxaloacetate transferase (48.00 ± 2.65 IU/L, without hydration) and eGFRs lower than the normal range (53.03 ± 3.05 and 59.66 ± 10.25 ml/min, respectively; p < .001 for all parameters). The renal function indicators were within normal limits in the group with a hydration volume higher than 2 L/day.
  
  
  CONCLUSIONS
  Renal function indicators in acyclovir-treated patients varied according to hydration volume. Health care providers should consider whether the hydration volume in each patient receiving intravenous acyclovir is sufficient for preventing nephropathy.
authors.affiliation: Neuroscience Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea even07@ewhain.net.
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
authors.affiliation: Division of Nursing Science, College of Health Science, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Youngsoon
authors.initials: Y
authors.lastname: Byun
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D005260:Female; D005440:Fluid Therapy; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir
keywords: CNS infection; acyclovir; renal function indicators