title: The facile surface chemical modification of a single glass nanopore and its use in the nonenzymatic detection of uric acid.
abstract: A conical glass nanopore was first modified with ultrathin gold nanofilm via a simple and innovative chemical reduction of HAuCl4 on a surface-attached poly(L-histidine) monolayer in the presence of a mild reductant, NH2OH·HCl, followed by surface functionalization with 2-thiouracil, and exploited for the selective nonenzymatic detection of uric acid and especially for serum sample detection.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. China. ydjin@ciac.ac.cn.
authors.forename: Haili
authors.initials: H
authors.lastname: He
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Lizhen
authors.initials: L
authors.lastname: Chen
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Jin
mesh_terms: D001681:Biological Assay; D001774:Blood Chemical Analysis / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D005898:Glass / Q000737:chemistry*; D058608:Nanopores; D013499:Surface Properties; D014498:Uracil / Q000737:chemistry; D014527:Uric Acid / Q000032:analysis*
chemical_list: D014527:Uric Acid; D014498:Uracil