title: Impact of serum nutritional status on physical function in african american and caucasian stroke survivors.
abstract: Background. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collected for analysis of lipids, uric acid, and albumin in 145 African American (AA) and 111 Caucasian (C) stroke survivors (age: 60 ± 1 years [mean ± SEM]). A six-minute walk was performed in a subset of stroke survivors (N = 134). Results. Triglycerides were higher and HDL-cholesterol and albumin lower in C than AA women stroke survivors (Ps < 0.05). Uric acid was lower in C than AA stroke survivors (P < 0.05). Compared to NHANESIII, HDL-cholesterol, albumin, and hemoglobin generally were lower (Ps < 0.05) and lipids were more favorable in stroke (Ps < 0.01). Uric acid was related to six-minute walk performance among a subset of stroke survivors (P < 0.05). Conclusion. In stroke, racial differences exist with regard to serum nutritional risk, but these differences are similar to that observed in the general population. Regardless of race, nutritional risk appears elevated above that of the general population with regard to many of the serum markers. As a modifiable biomarker, uric acid should be monitored closely as it may provide insight into the functional risk of stroke survivors.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Geriatric Research Education and Clinical Center, Baltimore Department of Veterans Affairs Medical Center (VAMC), Baltimore, MD 21201, USA.
authors.forename: Monica C
authors.initials: MC
authors.lastname: Serra
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
authors.forename: Charlene E
authors.initials: CE
authors.lastname: Hafer-Macko
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Ivey
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Macko
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Geriatric Research Education and Clinical Center, Baltimore Department of Veterans Affairs Medical Center (VAMC), Baltimore, MD 21201, USA.
authors.forename: Alice S
authors.initials: AS
authors.lastname: Ryan