title: Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α.
abstract: TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals' gene as control group were also examined. The GA 308 genotype of TNF-α differed significantly between the control group and the gastric cancer group (X(2) = 9.32, P < 0.05). Genotype frequencies of A/A (17.2%), A/G (26.2%), and G/G (9.1%) of the IL-10-1082 gene polymorphism in the gastric cancer group differed significantly compared to those of the control group (X(2) = 20.32, P < 0.05). The IL-10-1082 gene and the GA 308 genotype of the TNF-α gene were found to be susceptibility genes for gastric cancer.
authors.affiliation: Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China.
authors.forename: T
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China yuting686868@foxmail.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Ou
authors.affiliation: Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Cao
authors.affiliation: Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10