title: [Cytokines in Kawasaki disease].
abstract: We analyzed plasma levels of 14 cytokines in patients with Kawasaki disease (KD) before intravenous infusion of immunoglobulin (WIG) therapy using multiplex bead assay system. The results demonstrated that both inflammatory(TNF-α, IL-6, IL-8, IL-17, IFN-γ, G-CSF, MCP-1 and sIL-2Rα) and anti-inflammatory(IL-10, sTNFR1 and sTNFR2) cytokine levels were simultaneously elevated in patients refractory to the initial IVIG therapy. System-level understanding of the cytokine networks would be the key to develop a new therapeutic strategy to prevent coronary artery injuries in KD.
authors.forename: Jun
authors.initials: J
authors.lastname: Abe
mesh_terms: D003323:Coronary Aneurysm / Q000209:etiology; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
chemical_list: D016207:Cytokines; D016756:Immunoglobulins, Intravenous