title: Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis.
abstract: Cystic echinococcosis (CE) is a cosmopolitan disease caused by the dog tapeworm Echinococcus granulosus. The disease is difficult to diagnose, treat, and control and is responsible for considerable human morbidity and mortality globally. There is an urgent need for new diagnostic tests and new drugs for treatment of CE and the development of a vaccine against adult worms of E. granulosus in dogs. We recently presented a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 proteins. We undertook an extensive comparative analysis of the E. granulosus transcriptome using representative life stages (protoscoleces, cyst germinal cells and membranes, adult worms, and oncospheres) to explore different aspects of tapeworm biology and parasitism. The genome and transcriptome of E. granulosus provide a unique platform for post-genomic research and to facilitate the development of new, effective treatments and interventions for echinococcosis control.
authors.affiliation: State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
authors.forename: Wenbao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Shanghai-Ministry of Science and Technology Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, PR China.
authors.forename: Shengyue
authors.initials: S
authors.lastname: Wang
authors.affiliation: Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D000947:Antigens, Helminth / Q000032:analysis / Q000235:genetics; D001647:Bile Acids and Salts / Q000502:physiology; D002681:China; D018509:DNA, Helminth / Q000235:genetics*; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control; D004285:Dogs; D015195:Drug Design; D004443:Echinococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology* / Q000517:prevention & control / Q000662:veterinary; D048209:Echinococcus granulosus / Q000235:genetics* / Q000254:growth & development / Q000276:immunology; D048210:Echinococcus multilocularis / Q000235:genetics; D017238:Genes, Helminth; D016678:Genome; D023281:Genomics / Q000458:organization & administration; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D006376:Helminths / Q000145:classification / Q000235:genetics; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D058990:Molecular Targeted Therapy; D010802:Phylogeny; D013045:Species Specificity; D014612:Vaccines; D015047:Zoonoses
chemical_list: D000596:Amino Acids; D000871:Anthelmintics; D000947:Antigens, Helminth; D001647:Bile Acids and Salts; D018509:DNA, Helminth; D015801:Helminth Proteins; D014612:Vaccines