title: [The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza ].
abstract: OBJECTIVE
  To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients.
  
  
  METHODS
  The investigators examined 1203 patients (387 children, 509 people older than 16 years of age, 307 pregnant women) admitted to Moscow Clinical Infectious Diseases Hospital One with the clinical signs of acute respiratory viral diseases. Nasal lavage and autopsy specimens were used to isolate viral strains, then to sequence genomic fragments, and to determine receptor specificity.
  
  
  RESULTS
  Out of the 1203 examinees, 284 (23.6%) were influenza-positive: 221 (77.8%), 24 (8.5%), and 39 (13.7%) patients had influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B, respectively. Influenza was notified in 42,7% of the pregnant women. There was a preponderance of its moderate form; its severe form developed in single cases having comorbidities. One fatal outcome was registered. The intake of antiviral medications in the first 48 hours of the disease could prevent complications. The investigators revealed mutations in the strain isolated from the bronchoalveolar lavage fluid of a patient with severe pneumonia complicated by acute respiratory distress syndrome.
  
  
  CONCLUSIONS
  There is evidence that there are mutant A(H1N1)pdm09 viruses that have high pneumotropicity. The high risk of their circulation in the population and the risk of severe influenza forms involving the lower respiratory tract remain. Early antiviral therapy in the first 36-48 hours diminishes the clinical manifestations of influenza and reduces the risk of developing complications.
authors.forename: L V
authors.initials: LV
authors.lastname: Kolobukhina
authors.forename: E I
authors.initials: EI
authors.lastname: Burtseva
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shelkanov
authors.forename: S V
authors.initials: SV
authors.lastname: Al'khovskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Prilipov
authors.forename: L N
authors.initials: LN
authors.lastname: Merkulova
authors.forename: L B
authors.initials: LB
authors.lastname: Kisteneva
authors.forename: R V
authors.initials: RV
authors.lastname: Vartanian
authors.forename: I S
authors.initials: IS
authors.lastname: Kruzhkova
authors.forename: S V
authors.initials: SV
authors.lastname: Trushakova
authors.forename: K G
authors.initials: KG
authors.lastname: Krasnoslobodtsev
authors.forename: S M
authors.initials: SM
authors.lastname: Avdeev
authors.forename: O A
authors.initials: OA
authors.lastname: Sutochnikova
authors.forename: M V
authors.initials: MV
authors.lastname: Bazarova
authors.forename: E I
authors.initials: EI
authors.lastname: Kelly
authors.forename: O E
authors.initials: OE
authors.lastname: Ambrosi
authors.forename: n A
authors.initials: nA
authors.lastname: Malyshev
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: A G
authors.initials: AG
authors.lastname: Chuchalin
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D062665:Epidemiological Monitoring; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D009981:Influenza B virus / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D009031:Moscow / Q000453:epidemiology; D011247:Pregnancy; D012426:Russia / Q000453:epidemiology; D012621:Seasons; D013997:Time Factors; D055815:Young Adult
chemical_list: D000998:Antiviral Agents