title: [Comparative analysis of seven marine biological source of mineral drugs].
abstract: The marine biological source of mineral drugs recorded in Chinese Pharmacopoeia (2010 version) mainly including pearl, nacre, clam shell, common oyster shell, ark shell, cuttle bone, and sea-ear shell are widely used in clinical. Calcium carbonate and a small amount of protein are the main components in this type of drugs. In this paper, a systematical and comparable study were carried out by determination of calcium carbonate by EDTA titration method, the crystal of calcium carbonate by X-Ray powder diffraction and the total amino acids (TAAs) of the hydrolyzed samples by ultraviolet spectrophotometry method. As a result, the crystal structure is calcite for common oyster shell, mixture of calcite and aragonite for nacre and sea-ear shell, aragonite for the other drugs. The content of calcium carbonate ranged from 86% to 96%. Cuttle bone has the highest amount of TAAs among the seven drugs which reached 1.7% while clam shell has the lowest content of 0.16% on average. In conclusion, an effective method was developed for the quality control of marine mineral drugs by comprehensive analysis of calcium carbonate and TAAs in the seven marine mineral drugs.
authors.forename: Wei
authors.initials: W
authors.lastname: Si
authors.forename: Ru-na
authors.initials: RN
authors.lastname: A
authors.forename: Shang-rong
authors.initials: SR
authors.lastname: Li
authors.forename: Jing-Xian
authors.initials: JX
authors.lastname: Zhang
authors.forename: Wan-ying
authors.initials: WY
authors.lastname: Wu
authors.forename: Ya-jun
authors.initials: YJ
authors.lastname: Cui
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D060105:Animal Shells / Q000737:chemistry; D000818:Animals; D002119:Calcium Carbonate / Q000032:analysis* / Q000737:chemistry; D003460:Crystallization; D004492:Edetic Acid / Q000737:chemistry; D008974:Mollusca / Q000737:chemistry* / Q000145:classification; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry / Q000592:standards; D011786:Quality Control; D015203:Reproducibility of Results; D012623:Seawater; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D000596:Amino Acids; D004364:Pharmaceutical Preparations; D004492:Edetic Acid; D002119:Calcium Carbonate