title: [Hepatorotective activity of honeysuckle fruit extract in carbon tetrachloride intoxicated rats].
abstract: We have studied the effects of the extract from the dry pomace of honeysuckle fruits Lonicera edulis Turcz. and commercial reference preparation Legalon on weight and biochemical liver indexes in rats upon carbon tetrachloride intoxication. The extract of honeysuckle fruits favored a decrease in the total lipid content, reduced specific liver weight, and facilitated restoration of the activity of serum alanine aminotransferase and liver lysosomal enzymes. It the blood of rats, the extract increased superoxide dismutase activity, decreased glutathione level, enhanced antiradical activity, and reduced the level of malonic dialdehyde. The effect of administration of honeysuckle fruits pomace extract on restoration of the liver function was more pronounced than the effect of Legalon.
authors.forename: S E
authors.initials: SE
authors.lastname: Fomenko
authors.forename: N F
authors.initials: NF
authors.lastname: Kushnerova
authors.forename: V G
authors.initials: VG
authors.lastname: Sprygin
authors.forename: T V
authors.initials: TV
authors.lastname: Momot
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005638:Fruit / Q000737:chemistry; D005978:Glutathione / Q000097:blood; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D031239:Lonicera / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008055:Lipids; D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D005978:Glutathione