title: Discovering cancer biomarkers from clinical samples by protein microarrays.
abstract: Cancer biomarkers are of potential use in early cancer diagnosis, anticancer therapy development, and monitoring the responses to treatments. Protein-based cancer biomarkers are major forms in use, as they are much easier to be monitored in body fluids or tissues. For cancer biomarker discovery, high-throughput techniques such as protein microarrays hold great promises, because they are capable of global unbiased monitoring but with a miniaturized format. In doing so, novel and cancer type specific biomarkers can be systematically discovered at an affordable cost. In this review, we give a relatively complete picture on protein microarrays applied to clinical samples for cancer biomarker discovery, and conclude this review with the future perspectives.
authors.affiliation: Institute for Microsurgery of Limbs, Shanghai Sixth Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Niu
authors.forename: Li
authors.initials: L
authors.lastname: Cheng
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Sheng-Ce
authors.initials: SC
authors.lastname: Tao
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Zhou
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D040081:Protein Array Analysis / Q000379:methods*; D020543:Proteome / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020543:Proteome
keywords: Cancer biomarker; Cancer metastasis; Clinical samples; Protein microarray