title: The relationship of Bradykinin B₂ receptor gene variation with obesity, hypertension and lipid variables in obese patients.
abstract: OBJECTIVE
  This study examined the association of C-58T genotypes with obesity/hypertension related parameters and serum lipids in obese (n=108) and non-obese (n=80) patients.
  
  
  METHODS
  Bradykinin receptor (B₂R) C-58T genotypes were determined by PCR-RFLP.
  
  
  RESULTS
  B₂R gene C-58T frequencies for T/T (homozygous wild type), T/C (heterozygous) and C/C (homozygous polymorphic) genotypes for obese and non-obese patients were respectively: 36.1%, 37.5%; 45.4%, 52.5% and 18.5%, 10%. Obese patients using diuretic medication had lower C/C genotype frequency compared to T/T and T/C genotypes. Total cholesterol (T-Chol) (p=0.035) levels were found to be associated with B₂R C-58T polymorphism, where the T/T genotype had higher total cholesterol levels compared to the T/C genotype in obese patients. Non-obese patients using oral antidiabetic medication had higher C/C genotype frequency than that of T/T and T/C genotypes. Waist circumference (p=0.016) and diastolic blood pressure (p=0.01) levels were elevated in the non-obese subjects with the C/C genotype compared to T/C and T/T.
  
  
  CONCLUSIONS
  Although B₂R C-58T gene polymorphism was not found to be effective on obesity with logistic regression analysis in the whole study population in obese subjects, the T-Chol decreasing effect of the B₂R gene C allele and the higher waist circumference measurements in the non-obese subjects may indicate there may be a link between B₂R gene C-58T polymorphism and obesity in study populations of higher numbers.
authors.affiliation: Marmara University, Faculty of Science and Arts, Department of Biology, İstanbul, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Bakir
authors.affiliation: Marmara University, Faculty of Science and Arts, Department of Biology, İstanbul, Turkey.
authors.forename: Hasan Mert
authors.initials: HM
authors.lastname: Bozkuş
authors.affiliation: Marmara University, Faculty of Science and Arts, Department of Biology, İstanbul, Turkey.
authors.forename: Meliha
authors.initials: M
authors.lastname: Koldemir Gündüz
authors.affiliation: Istanbul University, Istanbul Medical Faculty, Department of Biostatistic and Medical Informatics, İstanbul, Turkey.
authors.forename: Penbe
authors.initials: P
authors.lastname: Çağatay
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of General Surgery, Istanbul.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Taşkın
authors.affiliation: Marmara University, Faculty of Science and Arts, Department of Biology, Göztepe-Istanbul, Turkey. belgin.susleyici@marmara.edu.tr.
authors.forename: Belgin
authors.initials: B
authors.lastname: Süsleyici Duman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood / Q000235:genetics*; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2 / Q000235:genetics*; D055105:Waist Circumference
chemical_list: D004232:Diuretics; D007004:Hypoglycemic Agents; D043782:Receptor, Bradykinin B2; D002784:Cholesterol