title: Optimal interferon-free therapy in treatment-experienced chronic hepatitis C patients.
abstract: Over the past year, interferon (IFN) free dosing regimens have become available to treat chronic hepatitis C. Offering high rates of sustained virological response (SVR), short treatment and improved tolerability, IFN-free treatment now represents the paradigm for both treatment-naïve and -experienced patients. Patients with prior treatment failure, in particular those with cirrhosis, still represent some of the most difficult to treat, but the availability of multiple agents that can interrupt several steps of the HCV lifecycle affords providers and patients with options that can be combined and individually tailored to each patient's unique needs to obtain high rates of SVR.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, University of Florida, Gainesville, FL, USA.
authors.forename: Joy
authors.initials: J
authors.lastname: Peter
authors.forename: David R
authors.initials: DR
authors.lastname: Nelson
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D002219:Carbamates; D004359:Drug Therapy, Combination / Q000379:methods* / Q000639:trends; D005449:Fluorenes / Q000627:therapeutic use; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011759:Pyrrolidines; D000069474:Sofosbuvir; D014542:Uridine Monophosphate / Q000031:analogs & derivatives / Q000627:therapeutic use; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D002219:Carbamates; D005449:Fluorenes; D007093:Imidazoles; D011759:Pyrrolidines; C586541:ledipasvir; D014542:Uridine Monophosphate; D014633:Valine; C549273:daclatasvir; D000069474:Sofosbuvir
keywords: direct acting antivirals; hepatitis C; treatment