title: Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B.
abstract: The present study was designed to assess the correlation between serum Golgi protein 73 (GP73) and liver pathological grading and staging in patients with chronic hepatitis B (CHB). Two hundred and fifty‑three patients with chronic hepatitis B virus (HBV) infections were enrolled in the present study. All patients received a serum GP73 test, and 91 CHB patients underwent liver biopsy. GP73 expression in liver tissue was assessed by immunohistochemical analysis. The results indicated that serum GP73 levels were positively correlated with disease progression in patients with chronic HBV infection (r=0.677). There was no significant difference in serum GP73 levels between hepatitis B e antigen‑positive and ‑negative patients (P>0.05). There were also no significant differences in serum GP73 levels among specimens with varying HBV DNA contents (P>0.05). Serum GP73 levels were positively correlated with increased liver pathological grading (r=0.737) and staging (r=0.692), and immunohistochemical analysis indicated that GP73 protein expression increased concurrently with liver pathological grading and staging. In conclusion, serum GP73 was found to be correlated with liver pathological grading and staging in patients with CHB, and may be an effective indicator for the evaluation of disease progression. However, serum GP73 levels were not associated with HBV replication.
authors.affiliation: Clinical Liver Center, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Zhengju
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Clinical Liver Center, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Xingnan
authors.initials: X
authors.lastname: Pan
authors.affiliation: Central Laboratory of Clinical Hepatology, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Kaipeng
authors.initials: K
authors.lastname: Wei
authors.affiliation: Liver Center Clinical Pathology, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Ding
authors.affiliation: Central Laboratory of Clinical Hepatology, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Wei
authors.affiliation: Clinical Liver Center, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Huanwen
authors.initials: H
authors.lastname: Yang
authors.affiliation: Clinical Liver Center, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D012720:Severity of Illness Index; D019562:Viral Load; D014779:Virus Replication; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; C410824:GOLM1 protein, human; D008565:Membrane Proteins