title: Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis.
abstract: For bladder cancer, a new diagnostic marker is needed to avoid painful cystoscopy. The aim of this study was to explore the efficacy of urinary miRNA-96 as molecular marker in bladder cancer diagnosis and its relation to bilharziasis. Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. Expression of miRNA-96 showed a significant difference among the three tested groups and also between benign and malignant bilharzial cases. Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, dr_sanaa_eissa@yahoo.com.
authors.forename: Sanaa
authors.initials: S
authors.lastname: Eissa
authors.forename: Haidy
authors.initials: H
authors.lastname: Habib
authors.forename: Esraa
authors.initials: E
authors.lastname: Ali
authors.forename: Yossif
authors.initials: Y
authors.lastname: Kotb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000652:urine*; D002648:Child; D006801:Humans; D035683:MicroRNAs / Q000652:urine*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D012552:Schistosomiasis / Q000097:blood; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C541492:MIRN96 microRNA, human; D035683:MicroRNAs