title: IL-17 cuts to the chase in colon cancer.
abstract: Although interleukin-17A (IL-17A) facilitates colon cancer development, its target cells remain elusive. In this issue of Immunity, Wang et al. (2014) now demonstrate that IL-17A receptors on the intestinal epithelium promote progression of APC mutant adenomas associated with IL-6 expression and that IL-17A confers chemotherapy resistance.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville VIC 3052, Australia. Electronic address: matthias.ernst@onjcri.org.au.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ernst
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville VIC 3052, Australia. Electronic address: tracy.putoczki@wehi.edu.au.
authors.forename: Tracy
authors.initials: T
authors.lastname: Putoczki
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000276:immunology*; D020895:Enterocytes / Q000502:physiology*; D006801:Humans; D053722:Receptors, Interleukin-17 / Q000378:metabolism*
chemical_list: C491673:Il17ra protein, mouse; D053722:Receptors, Interleukin-17