title: Cronkhite-Canada syndrome showing elevated levels of antinuclear and anticentromere antibody.
abstract: A 56-year-old female initially visited an otorhinolaryngologist because of an impaired sense of taste in September, 2010 and was referred to our facility in October, 2010. She was diagnosed with Basedow's disease for which she underwent subtotal thyroidectomy in 1984 and arthritis involving multiple joints, primarily affecting her hands. In addition, the anticentromere antibody (ACA) level was markedly high. On physical examination, alopecia as well as hyperpigmentation of the dorsum of the hands and back was observed. Dystrophic changes of the fingernails and a bilateral thumb abduction deformity were observed. Antinuclear antibodies were elevated. Gastrointestinal endoscopy and colonoscopy revealed the mucosa carpeted with strawberry-like polypoid lesions. Histopathological examination of the biopsied specimen of the stomach revealed a corkscrew-like appearance. Thus, the patient was diagnosed with Cronkhite-Canada syndrome (CCS). She admitted to our hospital in November, 2010. Oral prednisolone was administered with success. In July, 2012, her antimitochondrial M2 antibody level was elevated. To the best of our knowledge, the present case is the first patient with CCS, a history of Basedow's disease, and elevated levels of ACA and antimitochondrial M2 antibody. We consider the present case suggests CCS could be caused by immunological abnormality.
authors.affiliation: Department of Internal Medicine, Himeji St. Mary Hospital, Himeji, Japan, seisukeota@yahoo.co.jp.
authors.forename: Seisuke
authors.initials: S
authors.lastname: Ota
authors.forename: Akinori
authors.initials: A
authors.lastname: Kasahara
authors.forename: Shoko
authors.initials: S
authors.lastname: Tada
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Sachio
authors.initials: S
authors.lastname: Umena
authors.forename: Haruka
authors.initials: H
authors.lastname: Fukatsu
authors.forename: Toshio
authors.initials: T
authors.lastname: Noguchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood*; D001168:Arthritis / Q000150:complications; D005260:Female; D006111:Graves Disease / Q000150:complications; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; C538950:anticentromere antibody; D011239:Prednisolone