title: Chemically synthesized molecules with the targeting and effector functions of antibodies.
abstract: This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds—called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)—bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-molecule and biologic therapies, and may address many drawbacks associated with available treatments for cancer and other diseases.
authors.affiliation: Department of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06511, United States.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McEnaney
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Fitzgerald
authors.forename: Andrew X
authors.initials: AX
authors.lastname: Zhang
authors.forename: Eugene F
authors.initials: EF
authors.lastname: Douglass
authors.forename: Weifang
authors.initials: W
authors.lastname: Shan
authors.forename: Aaron
authors.initials: A
authors.lastname: Balog
authors.forename: Mariya D
authors.initials: MD
authors.lastname: Kolesnikova
authors.forename: David A
authors.initials: DA
authors.lastname: Spiegel
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D000954:Antigens, Surface / Q000737:chemistry / Q000378:metabolism; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D043425:Glutamate Carboxypeptidase II / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D062105:Molecular Docking Simulation; D008970:Molecular Weight; D010587:Phagocytosis / Q000187:drug effects; D011487:Protein Conformation; D017452:Receptors, IgG / Q000378:metabolism
chemical_list: D000906:Antibodies; D000954:Antigens, Surface; D017452:Receptors, IgG; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II