title: Primary malignant melanoma of the ovary arising in a cystic teratoma; case report and review of the literature.
abstract: Primary malignant melanoma of the ovary arising in a cystic teratoma is extremely rare. There is no melanocytic component in the normal ovarian tissue. However, melanocytes may be present in a cystic teratoma of the ovary, especially at the basal layer of squamous epithelium. We report a case of primary malignant melanoma of the ovary arising in a cystic teratoma. We demonstrate junctional activity of melanocytes showing malignant transformation with both radial and vertical growth phases, a feature diagnostic for primary malignant melanoma but not always demonstrated in such cases. We compiled and reviewed twelve cases that are also able to demonstrate junctional activity.
authors.affiliation: Harbor-UCLA Medical Center. jlee91780@gmail.com.
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: John
authors.initials: J
authors.lastname: Magpayo
authors.forename: Charles
authors.initials: C
authors.lastname: Panchari
authors.forename: Shi-Kaung
authors.initials: SK
authors.lastname: Peng
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*