title: Attenuation of copaiba oil in hepatic damage in rats.
abstract: OBJECTIVE
  To investigate the copaiba oil on the hepatic damage induced by acetaminophen, comparing against corn oil.
  
  
  METHODS
  Fifty four rats were distributed into nine study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours after the acetaminophen, the corn's groups were similar than copaiba oil groups; and N-Acetyl-Cysteine Group, that received the N-Acetyl-Cysteine two hours after the acetaminophen. Euthanasia was performed after 24 hours. The serum levels transaminases, bilirubin and canalicular enzymes were analyzed.
  
  
  RESULTS
  The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 and corn's groups showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and ɤ GT (p>0.05). The therapy copaiba group showed the highest levels of total bilirubin and was statistically different from the other groups (p<0.01).
  
  
  CONCLUSIONS
  Copaiba oil administered prophylactically for seven days and therapeutically 2 hours after the acetaminophen acute intoxication offered a potential hepato protection against paracetamol-induced hepatic damage, normalizing the biochemical parameters similarly to N-Acetyl-Cysteine, and the treatment with corn oil shows no effect on the liver damage.
authors.affiliation: Department of Integrate Health, Medical School, Para State University, Belem, PA, Brazil.
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
authors.affiliation: School of Medicine, UEPA, Brazil.
authors.forename: Felipe D'Almeida
authors.initials: FD
authors.lastname: Costa
authors.affiliation: School of Medicine, UEPA, Belem, PA, Brazil.
authors.forename: Diego Matos de
authors.initials: DM
authors.lastname: Vasconcelos
authors.affiliation: School of Medicine, UEPA, Belem, PA, Brazil.
authors.forename: Lauro Augusto Veloso
authors.initials: LA
authors.lastname: Costa
authors.affiliation: Medical School, UEPA, Belem, PA, Brazil.
authors.forename: Edson Yuzur
authors.initials: EY
authors.lastname: Yasojima
authors.affiliation: School of Medicine, UEPA, Belem, PA, Brazil.
authors.forename: Renan Kleber Costa
authors.initials: RK
authors.lastname: Teixeira
authors.affiliation: School of Medicine, UEPA, Belem, PA, Brazil.
authors.forename: Vitor Nagai
authors.initials: VN
authors.lastname: Yamaki
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000111:Acetylcysteine / Q000627:therapeutic use; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D003314:Corn Oil / Q000627:therapeutic use; D004195:Disease Models, Animal; D007887:Fabaceae / Q000737:chemistry*; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D016896:Treatment Outcome; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D010938:Plant Oils; D000082:Acetaminophen; D003314:Corn Oil; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D000111:Acetylcysteine