title: Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.
abstract: Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease.
authors.affiliation: Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; New York Medical College, Valhalla, NY, USA.
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Liu
authors.affiliation: Laboratory of Metabolic Research, Felsenstein Medical Research Center, Tel Aviv University, Petach Tikva, Israel.
authors.forename: Pnina
authors.initials: P
authors.lastname: Green
authors.affiliation: Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA; Department of Radiology, Columbia University, New York, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: John Mann
authors.affiliation: Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Stanley I
authors.initials: SI
authors.lastname: Rapoport
authors.affiliation: Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA. Electronic address: es2316@columbia.edu.
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Sublette
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D015213:Neuroimmunomodulation / Q000502:physiology
chemical_list: D005231:Fatty Acids, Unsaturated
keywords: Bipolar disorder; Brain; Depression; Lipid metabolism; Polyunsaturated fatty acids; Schizophrenia