title: The Role of HLA in MS Susceptibility and Phenotype.
abstract: One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25-30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Building 71/918 Riyal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia. j.greer@uq.edu.au.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Greer
mesh_terms: D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology*; D010641:Phenotype
chemical_list: D006680:HLA Antigens
keywords: Clinical phenotypes; Disease susceptibility; Human leucocyte antigen (HLA); Keywords; Multiple sclerosis (MS)