title: Effects of External and Internal Hyperthermia on LDL Transport and Accumulation Within an Arterial Wall in the Presence of a Stenosis.
abstract: Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the atherosclerotic plaque formation. Effects of external and internal hyperthermia on LDL concentration levels are established along with the range of influence of these effects. Various modules of the current work are comprehensively compared with pertinent literature and are found to be in excellent agreement. The effects of external and internal hyperthermia as well as the load level and the axial location of the plaque formation on LDL transport and accumulation for a stenosed artery are established in this work.
authors.affiliation: Department of Mechanical Engineering, University of California, Riverside, CA, 92521, USA.
authors.forename: Marcello
authors.initials: M
authors.lastname: Iasiello
authors.forename: Kambiz
authors.initials: K
authors.lastname: Vafai
authors.forename: Assunta
authors.initials: A
authors.lastname: Andreozzi
authors.forename: Nicola
authors.initials: N
authors.lastname: Bianco
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tavakkoli
mesh_terms: D001158:Arteries / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000503:physiopathology*; D005334:Fever / Q000503:physiopathology*; D006358:Hot Temperature; D006801:Humans; D008077:Lipoproteins, LDL / Q000502:physiology*; D008955:Models, Cardiovascular
chemical_list: D008077:Lipoproteins, LDL