title: Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer's Mice.
abstract: Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer's disease (3×Tg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.
authors.affiliation: Department of Nursing, Mackay Junior College of Medicine, Nursing and Management, Taipei 112, Taiwan.
authors.forename: Hei-Jen
authors.initials: HJ
authors.lastname: Huang
authors.affiliation: Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Chen
authors.affiliation: School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Rong-Hong
authors.initials: RH
authors.lastname: Hsieh
authors.affiliation: Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan.
authors.forename: Hsiu Mei
authors.initials: HM
authors.lastname: Hsieh-Li