title: Analysis of several loci from genome-wide association studies in Parkinson's disease in mainland China.
abstract: Large-scale meta-analyses of genome-wide association studies in Parkinson's disease (PD) have identified a number of susceptibility loci in sporadic PD. Since the characteristics of those loci in a Han Chinese population from mainland China were unknown, we performed a case-control replication study in this population and evaluated several single nucleotide polymorphisms (SNPs) identified in a recent GWAS-meta-analysis. In total, 933 subjects comprised of 460 PD patients and 473 controls were genotyped. We found strong evidence of an association for rs708723 in RAB7L1 in the total sample (genotype p=0.01, allele p=0.01, OR=0.78, 95% CI=0.65-0.94). With rs156429 in GPNMB, there was a significant difference in genotype and allele distribution between male PD patients and the control subgroup (genotype p=0.01, allele p=0.01, OR=0.67, 95% CI=0.49-0.92). However, we did not observe any significant difference in genotype or allele distribution between PD and control for rs34016896 in NMD3 and rs6812193 in STBD1.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Guo
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Kang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Sun
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Dan-Ling
authors.initials: DL
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Yan
authors.affiliation: Department of Neurology, Henan provincial people's hospital, Zhengzhou, 450003 Henan, People's Republic of China.
authors.forename: Chang-Shui
authors.initials: CS
authors.lastname: Xu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China. Electronic address: bstang7398@163.com.
authors.forename: Bei-Sha
authors.initials: BS
authors.lastname: Tang
mesh_terms: D016022:Case-Control Studies; D002681:China; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics; D056726:Genetic Association Studies; D056426:Genetic Loci; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics; D020691:rab GTP-Binding Proteins; D020761:rab1 GTP-Binding Proteins / Q000235:genetics
chemical_list: D005346:Fibroblast Growth Factors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D016601:RNA-Binding Proteins; D020691:rab GTP-Binding Proteins; D020761:rab1 GTP-Binding Proteins; C416003:FGF20 protein, human; C503042:GPNMB protein, human; C475570:NMD3 protein, human; C000598762:Rab29 protein, human; C116148:STBD1 protein, human
keywords: Chinese population; GWAS; GWAS-meta-analysis; Parkinson’s disease; Single nucleotide polymorphism