title: Retinal nerve fibre layer thickness measurements after successful retinal detachment repair with silicone oil endotamponade.
abstract: OBJECTIVE
  To measure peripapillary retinal nerve fibre layer thickness (RNFL) by using spectral domain optical coherence tomography (OCT) in patients who underwent successful retinal detachment repair with silicone oil tamponade.
  
  
  METHODS
  Sixty patients treated with pars plana vitrectomy and silicone oil tamponade for retinal detachment were prospectively enrolled in a study. Peripapillary RNFL thickness was measured with a Cirrus HD-OCT at 7, 30, 90 and 180 days postoperatively, using an Optic Disc Cube 200×200 protocol. The fellow eye of each study patient served as a control. Median peripapillary RNFL thickness in silicone oil filled eyes was compared with control eyes.
  
  
  RESULTS
  The median RNFL thickness in the group of vitrectomised eyes was significantly higher compared with control eyes at every visit. The analysis of variance showed that the median thickness in vitrectomised eyes differed between visits (F=4,3023; p=0.006). There was no time-related trend for RNFL thickness in this group. The analysis of variance of RNFL thickness in the fellow, unoperated eyes showed no difference between visits (F=2,3426; p=0.075).
  
  
  CONCLUSIONS
  In patients with silicone oil tamponade, peripapillary RNFL was significantly thicker in comparison with fellow unoperated eyes over a 6-month period.
  
  
  BACKGROUND
  NCT 01255306.
authors.affiliation: University Department of Ophthalmology, University Clinical Centre 'Sestre milosrdnice', Zagreb, Croatia.
authors.forename: Mia
authors.initials: M
authors.lastname: Zoric Geber
authors.affiliation: University Department of Ophthalmology, University Clinical Centre 'Sestre milosrdnice', Zagreb, Croatia.
authors.forename: Goran
authors.initials: G
authors.lastname: Bencic
authors.affiliation: University Department of Ophthalmology, University Clinical Centre 'Sestre milosrdnice', Zagreb, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Vatavuk
authors.affiliation: University Department of Ophthalmology, University Clinical Centre 'Sestre milosrdnice', Zagreb, Croatia.
authors.forename: Renata
authors.initials: R
authors.lastname: Ivekovic
authors.affiliation: Retina Service, UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Friberg
mesh_terms: D000368:Aged; D058450:Endotamponade; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis / Q000601:surgery*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012827:Silicone Oils; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D012827:Silicone Oils
keywords: Imaging; Inflammation; Optic Nerve; Retina