title: [Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection].
abstract: OBJECTIVE
  To identify clinical, laboratorial and radiographic predictors for Bordetella pertussis infection.
  
  
  METHODS
  This was a retrospective study, which analyzed medical records of all patients submitted to a molecular diagnosis (qPCR) for B. pertussis from September 2011 to January 2013. Clinical and laboratorial data were reviewed, including information about age, sex, signs/symptoms, length of hospitalization, blood cell counts, imaging findings, coinfection with other respiratory pathogens and clinical outcome.
  
  
  RESULTS
  222 cases were revised. Of these, 72.5% had proven pertussis, and 60.9% were under 1 year old. In patients aging up to six months, independent predictors for B. pertussis infection were cyanosis (OR 8.0, CI 95% 1.8-36.3; p=0.007) and lymphocyte count >10(4)/μL (OR 10.0, CI 95% 1.8-54.5; p=0.008). No independent predictors of B. pertussis infection could be determined for patients older than six months. Co-infection was found in 21.4% of patients, of which 72.7% were up to six months of age. Adenovirus was the most common agent (40.9%). In these patients, we were not able to identify any clinical features to detect patients presenting with a respiratory co-infection, even though longer hospital stay was observed in patients with co-infections (12 vs. 6 days; p=0.009).
  
  
  CONCLUSIONS
  Cyanosis and lymphocytosis are independent predictors for pertussis in children up to 6 months old.
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Camila Vieira
authors.initials: CV
authors.lastname: Bellettini
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Andressa Welter
authors.initials: AW
authors.lastname: de Oliveira
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Cintia
authors.initials: C
authors.lastname: Tusset
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Ludmila Fiorenzano
authors.initials: LF
authors.lastname: Baethgen
authors.affiliation: Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brasil.
authors.forename: Sérgio Luís
authors.initials: SL
authors.lastname: Amantéa
authors.affiliation: Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brasil.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Motta
authors.affiliation: Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brasil.
authors.forename: Aline
authors.initials: A
authors.lastname: Gasparotto
authors.affiliation: Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brasil.
authors.forename: Huander Felipe
authors.initials: HF
authors.lastname: Andreolla
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil; Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brasil. Electronic address: acpasqualotto@hotmail.com.
authors.forename: Alessandro C
authors.initials: AC
authors.lastname: Pasqualotto
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011859:Radiography; D012189:Retrospective Studies; D014917:Whooping Cough / Q000175:diagnosis*; D055815:Young Adult
keywords: Bordetella pertussis; Coinfection; Coinfecção; Coqueluche; Infection; Infecção; Whooping cough