title: S100A4 expression and prognosis of gastric cancer: a meta-analysis.
abstract: The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95%CI). A total of 7 eligible studies that included 1257 gastric cancer patients were analyzed. We did not find a prognostic value for S100A4 in gastric cancer (HR = 1.48, 95%CI = 0.77 to 2.82, P = 0.24). In conclusion, the present study indicated that S100A4 expression level is not a prognostic factor for gastric cancer.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: L-B
authors.initials: LB
authors.lastname: Zhou
authors.affiliation: Department of Digestive Medicine, Shanghai Eighth People's Hospital, Shanghai, China lixinghua212@yeah.net.
authors.forename: X-H
authors.initials: XH
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011379:Prognosis; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C077591:S100A4 protein, human