title: [Identification of transthyretin posttranslational modifications 1n human blood using mass-spectrometric methods].
abstract: Transthyretin, one of the major plasma proteins, has a number of posttranslational modifications and mutations, some of which are associated with the development of severe diseases, for instance, familial amyloid neuropathy and Alzheimer's disease. In order to investigate the role of modified forms in the development of these diseases a complex analytical platform, based on two mass-spectrometric approaches (bottom-up and op-down) has been developed. The high efficiency of this method was shown using 10 plasma samples obtained from patients with Alzheimer's disease and healthy individuals.
authors.forename: I A
authors.initials: IA
authors.lastname: Popov
authors.forename: N L
authors.initials: NL
authors.lastname: Starodubtseva
authors.forename: M I
authors.initials: MI
authors.lastname: Indeĭkina
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Kostiukevich
authors.forename: A S
authors.initials: AS
authors.lastname: Kononikhin
authors.forename: M I
authors.initials: MI
authors.lastname: Nikolaeva
authors.forename: E N
authors.initials: EN
authors.lastname: Kukaev
authors.forename: S A
authors.initials: SA
authors.lastname: Kozin
authors.forename: A A
authors.initials: AA
authors.lastname: Makarov
authors.forename: E N
authors.initials: EN
authors.lastname: Nikolaev
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology; D028227:Amyloid Neuropathies, Familial / Q000097:blood* / Q000473:pathology; D006801:Humans; D013058:Mass Spectrometry; D011228:Prealbumin / Q000235:genetics* / Q000302:isolation & purification*; D011499:Protein Processing, Post-Translational / Q000235:genetics
chemical_list: D011228:Prealbumin