title: Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus.
abstract: Even in the era of successful combination antiretroviral therapy (cART), co-infection of Hepatitis C virus (HCV) remains one of the leading causes of non-AIDS-related mortality and morbidity among HIV-positive individuals as a consequence of accelerated liver fibrosis and end-stage liver disease (ESLD). The perturbed liver microenvironment and induction of host pro-inflammatory mediators in response to HIV and HCV infections, play a pivotal role in orchestrating the disease pathogenesis and clinical outcomes. How these viruses communicate each other via chemokine CCL2 and exploit the liver specific cellular environment to exacerbate liver fibrosis in HIV/HCV co-infection setting is a topic of intense discussion. Herein, we provide recent views and insights on potential mechanisms of CCL2 mediated immuno-pathogenesis, and HIV-HCV cross-talk in driving liver inflammation. We believe CCL2 may potentially serve an attractive target of anti-fibrotic intervention against HIV/HCV co-infection associated co-morbidities.
authors.affiliation: Centre of Excellence for Research in AIDS, Faculty of Medicine, University of Malaya, Lambah Pantai 50603, Kuala Lumpur, Malaysia. awansari@um.edu.my.
authors.forename: A W Wahid
authors.initials: AW
authors.lastname: Ansari
authors.forename: Reinhold E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: Esaki M
authors.initials: EM
authors.lastname: Shankar
authors.forename: Adeeba
authors.initials: A
authors.lastname: Kamarulzaman
mesh_terms: D018932:Chemokine CCL2 / Q000378:metabolism*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006526:Hepatitis C / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000821:virology; D014779:Virus Replication
chemical_list: D018932:Chemokine CCL2