title: Risk factors for colorectal neoplasms based on colonoscopy and pathological diagnoses of Chinese citizens: a multicenter, case-control study.
abstract: OBJECTIVE
  Since observational data in the urban residents are required to better assess the risk factors of colorectal neoplasm occurrence and the effectiveness of colonoscopy screening and surveillance, we conducted a case-control study at multicenters in China to identify patient characteristics and neoplasm features of colorectal adenoma (CRA) and colorectal carcinoma (CRC).
  
  
  METHODS
  A total of 4089 patients who had undergone a colonoscopy from 19 hospitals were enrolled, of which 1106 had CRA and 466 had CRC. They were compared with controls. The analysis provides features and risk factors of colorectal neoplasm using multivariate logistic regression.
  
  
  RESULTS
  Increasing age, a family history of colorectal cancer or previous cases of colorectal adenoma or hypertension disease, gastrointestinal surgery, regular intake of pickled food (adjusted odds ratio [aOR] 1.42, 95 % confidence interval [CI], 1.048-1.924), consumption of alcohol, and a positive result of fecal occult blood testing (FOBT; aOR 2.509, 95 % CI 1.485-4.237) were associated with an increased risk of CRA. In the CRC group, increasing age, regular intake of pickled foods, and a positive FOBT result were risk factors. In addition, a positive abdominal computed tomography (CT) before a colonoscopy and physical signs of emaciation were also significantly associated with an increasing risk of colorectal carcinoma. Regular intake of vegetables decreased the risk of both CRA and CRC.
  
  
  CONCLUSIONS
  Age, pickled foods, and a positive FOBT are risk factors for colorectal neoplasm. Vegetable intake was associated with a decreased risk of CRA and CRC.
authors.affiliation: State Key Laboratory of Oncogene and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Department of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Qin
authors.forename: Lan-Qing
authors.initials: LQ
authors.lastname: Ma
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
authors.forename: Ya-Rong
authors.initials: YR
authors.lastname: Chen
authors.forename: Liang-Ru
authors.initials: LR
authors.lastname: Zhu
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Hu
authors.forename: Jing-Nan
authors.initials: JN
authors.lastname: Li
authors.forename: Kun-He
authors.initials: KH
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Xiao
authors.forename: Hao-Yan
authors.initials: HY
authors.lastname: Chen
authors.forename: Ying-Xuan
authors.initials: YX
authors.lastname: Chen
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Fang
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology*; D000367:Age Factors; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D005247:Feeding Behavior; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009780:Occult Blood; D012307:Risk Factors