title: PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window.
abstract: PEDOT nanoparticles with a suitable nanosize of 17.2 nm, broad adsorption from 700 to 1250 nm, and photothermal conversion efficiency (η) of 71.1%, were synthesized using an environmentally friendly hydrothermal method. Due to the electrostatic attraction between indocyanine green (ICG) and PEDOT, the stability of ICG in aqueous solution was effectively improved. The PEDOT nanoparticles modified with glutaraldehyde (GTA) targeted bacteria directly, and MTT experiments demonstrated the low toxicity of PEDOT:ICG@PEG-GTA in different bacteria and cells. Pathogenic bacteria were eﬀectively killed by photodynamic therapy (PDT) and photothermal therapy (PTT) with PEDOT:ICG@PEG-GTA in the presence of near-infrared (NIR) irradiation (808 nm for PDT, and 1064 nm for PTT). The combination of the two different bacteriostatic methods was significantly more effective than PTT or PDT alone. The obtained PEDOT:ICG@PEG-GTA may be used as a novel synergistic agent in combination photodynamic and photothermal therapy to inactivate pathogenic bacteria in both the NIR I and II window.
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, PR China; Department of Chemistry, Renmin University of China, Beijing 100872, PR China.
authors.forename: Luoyuan
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, PR China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Panlong
authors.initials: P
authors.lastname: Hao
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, PR China.
authors.forename: Zhangguo
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing 100872, PR China.
authors.forename: Limin
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, PR China. Electronic address: mazhanfang@cnu.edu.cn.
authors.forename: Zhanfang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, PR China. Electronic address: Jenniferjingzhou@gmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D004926:Escherichia coli / Q000187:drug effects / Q000648:ultrastructure; D005453:Fluorescence; D005976:Glutaral / Q000633:toxicity; D006801:Humans; D006979:Hyperthermia, Induced; D007208:Indocyanine Green / Q000633:toxicity; D050296:Microbial Viability / Q000187:drug effects; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000633:toxicity; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000648:ultrastructure; D013242:Sterilization
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D011092:Polyethylene Glycols; D007208:Indocyanine Green; D005976:Glutaral
keywords: NIR II window; PEDOT; Pathogenic bacteria; Photodynamic therapy; Photothermal therapy