title: Determination of chlorophenols in honey samples using in-situ ionic liquid-dispersive liquid-liquid microextraction as a pretreatment method followed by high-performance liquid chromatography.
abstract: In-situ ionic liquid-dispersive liquid-liquid microextraction (IL-DLLME) method was developed as a pretreatment method for the detection of six chlorophenols (CPs) in honey samples. The hydrophobic ionic liquid [C4MIM][NTf2], formed in-situ by the hydrophilic ionic liquid [C4MIM][BF4] and the ion exchange reagent LiNTf2 was used as the microextractant solvent of CPs from honey sample. Then the enriched analytes were back-extracted into 40 μL of 0.14 M NaOH solution and finally subjected to analysis by high-performance liquid chromatography. The method showed low limit of detection of CPs, 0.8-3.2 μg/L and high enrichment factor, 34-65 with the recoveries range from 91.60% to 114.33%. The method is simple, rapid, environmentally friendly and with high extraction efficiency.
authors.affiliation: Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Lab of Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Fan
authors.affiliation: Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Lab of Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, PR China.
authors.forename: Nai
authors.initials: N
authors.lastname: Li
authors.affiliation: Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Lab of Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, PR China. Electronic address: caoxl@th.btbu.edu.cn.
authors.forename: Xueli
authors.initials: X
authors.lastname: Cao
mesh_terms: D002733:Chlorophenols / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006722:Honey / Q000032:analysis*; D052578:Ionic Liquids / Q000737:chemistry; D059627:Liquid Phase Microextraction / Q000379:methods*
chemical_list: D002733:Chlorophenols; D052578:Ionic Liquids
keywords: Chlorophenols; High-performance liquid chromatography (HPLC); Honey; In-situ ionic liquid-dispersive liquid–liquid microextraction (IL-DLLME); Pretreatment