title: Evolutionary genomics and population structure of Entamoeba histolytica.
abstract: Amoebiasis caused by the gastrointestinal parasite Entamoeba histolytica has diverse disease outcomes. Study of genome and evolution of this fascinating parasite will help us to understand the basis of its virulence and explain why, when and how it causes diseases. In this review, we have summarized current knowledge regarding evolutionary genomics of E. histolytica and discussed their association with parasite phenotypes and its differential pathogenic behavior. How genetic diversity reveals parasite population structure has also been discussed. Queries concerning their evolution and population structure which were required to be addressed have also been highlighted. This significantly large amount of genomic data will improve our knowledge about this pathogenic species of Entamoeba.
authors.affiliation: Division of Parasitology, National Institute of Cholera and Enteric Diseases, P-33, CIT Road, Scheme XM, Beliaghata, Kolkata 700010, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Das
authors.affiliation: Division of Parasitology, National Institute of Cholera and Enteric Diseases, P-33, CIT Road, Scheme XM, Beliaghata, Kolkata 700010, India.
authors.forename: Sandipan
authors.initials: S
authors.lastname: Ganguly
keywords: Disease outcome; Genetic polymorphism; Genetic recombination; Genotyping; Short tandem repeat loci; Single nucleotide polymorphism