title: The concise synthesis of unsymmetric triarylacetonitriles via Pd-catalyzed sequential arylation: a new synthetic approach to tri- and tetraarylmethanes.
abstract: The selective synthesis of multiarylated acetonitriles via sequential palladium-catalyzed arylations of chloroacetonitrile is reported. The three aryl groups are installed via a Pd-catalyzed Suzuki-Miyaura cross coupling reaction followed by back-to-back C-H arylations to afford triarylacetonitriles in three steps with no over-arylation at any step. The triarylacetonitrile products can be converted into highly functionalized species including tetraarylmethanes. This new strategy provides rapid access to a variety of unsymmetrical tri- and tetraarylmethane derivatives from simple, readily available starting materials.
authors.affiliation: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University , Nagoya 464-8602, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nambo
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yar
authors.forename: Joel D
authors.initials: JD
authors.lastname: Smith
authors.forename: Cathleen M
authors.initials: CM
authors.lastname: Crudden
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D009570:Nitriles; D010165:Palladium; D008697:Methane