title: Systemic study on the biogenic pathways of yezo’otogirins: total synthesis and antitumor activities of (±)-yezo’otogirin C and its structural analogues.
abstract: A systematic study of the biomimetic pathways to yezo’otogirin C under aerobic and anaerobic conditions has been investigated, and both are found to be feasible pathways to the natural product depending on the physiological conditions. Because of the lower activation energy, the aerobic process would be more favorable when the in vivo oxygen level is high. In the course of this study, a highly efficient synthetic route to (±)-yezo’otogirin C has been established in four steps (31% overall yield) from a readily available compound without using any protecting groups. The natural product and its structural analogues exhibited antitumor activities against several human cancer cell lines and appeared to arrest cell cycles in different phases.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Jingming
authors.initials: J
authors.lastname: Cao
authors.forename: Mengxun
authors.initials: M
authors.lastname: Zhang
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Lan
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhu
authors.forename: Guangyan
authors.initials: G
authors.lastname: Du
authors.forename: Shuzhong
authors.initials: S
authors.lastname: He
authors.forename: Chi-Sing
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C000589995:yezo'otogirin C