title: Bisphenol A Concentration in Breast Milk following Consumption of a Canned Coffee Drink.
abstract: BACKGROUND
  Bisphenol A (BPA) is generally considered to be an endocrine disruptor. Previous reports indicate that the BPA content in breast milk is higher than that in serum; however, BPA is considered to be excreted in the urine and not to accumulate in the body.
  
  
  OBJECTIVE
  The current study aimed at evaluating the migration of BPA from a commercially available canned coffee drink in a container that was coated with vinyl chloride resin into breast milk.
  
  
  METHODS
  Ten women who had breastfed for ≥12 months, were ready to cease breastfeeding, and drank commercially available canned coffee drinks daily were approached to participate. A canned coffee drink in which the can contained vinyl chloride resin was chosen. Samples (5 mL each) of urine and breast milk were collected prior to and after ingestion (1 h, 2 h, 4 h, and 6 h) of a 190-mL canned coffee drink. BPA measurements were conducted using an ELISA kit.
  
  
  RESULTS
  Each 190-mL can of coffee contained 196.9 ng/mL BPA, resulting in 37.4 μg that was consumed in each drink. In breast milk, peak BPA excretion occurred at 1 hour; in urine, excretion occurred rapidly during the first hour, remaining relatively unchanged at 2 hours.
  
  
  CONCLUSIONS
  The present results indicate that BPA is excreted into the breast milk in addition to the urine and feces. Therefore, it is important to reduce both direct and indirect dietary BPA intake.
authors.affiliation: Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan ytateoka@belle.shiga-med.ac.jp.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Tateoka
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000032:analysis / Q000493:pharmacokinetics*; D003069:Coffee / Q000737:chemistry*; D004327:Drinking Behavior; D004785:Environmental Pollutants / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging; D057141:Food, Preserved / Q000032:analysis; D006801:Humans; D008425:Maternal Behavior; D008895:Milk, Human / Q000737:chemistry*; D010636:Phenols / Q000032:analysis / Q000493:pharmacokinetics*; D013997:Time Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D003069:Coffee; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; breastfeeding