title: Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI).
abstract: Two cases of malignant hypertension presenting with acute kidney injury, thrombocytopenia and hemolytic anemia are presented. In both patients a prolonged duration of renal replacement therapy was required. The plasma levels of ADAMTS13 enzyme were not helpful in delineating the precise pathogenesis in both cases, as the decrements were not severe. We discuss the clinic-pathologic correlation of the biopsy findings and persistence of AKI.
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA ; Section of Renal Diseases,Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Chike
authors.initials: C
authors.lastname: Nzerue
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA.
authors.forename: Kemi
authors.initials: K
authors.lastname: Oluwole
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA.
authors.forename: David
authors.initials: D
authors.lastname: Adejorin
authors.affiliation: Renal Pathology division, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Paisit
authors.initials: P
authors.lastname: Paueksakon
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA ; Division of Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Fremont
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA.
authors.forename: Richmond
authors.initials: R
authors.lastname: Akatue
authors.affiliation: Department of Medicine, Meharry Medical College, Nashville, TN, USA ; Section of Renal Diseases,Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Marquetta
authors.initials: M
authors.lastname: Faulkner
keywords: irreversible; malignant hypertension; thrombotic microangiopathy