title: Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy.
abstract: The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps, through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Cao
authors.forename: Zhen-Jie
authors.initials: ZJ
authors.lastname: Li
authors.forename: Wen-Wu
authors.initials: WW
authors.lastname: Sun
authors.forename: Shashwat
authors.initials: S
authors.lastname: Malhotra
authors.forename: Yuan-Liang
authors.initials: YL
authors.lastname: Ma
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar