title: Sodium hydrosulfide relieves neuropathic pain in chronic constriction injured rats.
abstract: Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it needs further experimental research. Furthermore, the clinical potential that NaHS was used to relieve pain was limited so it would be required. To address these issues, the rats of sciatic nerve chronic constriction injury (CCI) were given intraperitoneal injection of NaHS containing hydrogen sulfide (H2S). The experimental results showed that NaHS inhibited the reduction of paw withdrawal thermal latency (PWTL), mechanical withdrawal threshold (MWT), and the level of pCREB in CCI rats in a dose-dependent manner and they were greatly decreased in NaHSM group (P < 0.05). NaHS alleviates chronic neuropathic pain by inhibiting expression of pCREB in the spinal cord of Sprague-Dawley rats.
authors.affiliation: Department of Anesthesiology, The First Hospital of Fujian Medical University, Fuzhou 350005, China.
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350005, China.
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Luo
authors.affiliation: Department of Anesthesiology, The First Hospital of Fujian Medical University, Fuzhou 350005, China.
authors.forename: Cai-Zhu
authors.initials: CZ
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology, The First Hospital of Fujian Medical University, Fuzhou 350005, China.
authors.forename: Jin-Zhuan
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, The First Hospital of Fujian Medical University, Fuzhou 350005, China.
authors.forename: Xian-Zhong
authors.initials: XZ
authors.lastname: Lin