title: Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.
abstract: Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases.
authors.affiliation: Department of Pharmacology and Physiology, Drexel University, Philadelphia, PA, 19102, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Enman
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, 10595, USA.
authors.forename: Esther L
authors.initials: EL
authors.lastname: Sabban
authors.affiliation: Department of Pharmacology and Physiology, Drexel University, Philadelphia, PA, 19102, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: McGonigle
authors.affiliation: Department of Pharmacology and Physiology, Drexel University, Philadelphia, PA, 19102, USA.
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Van Bockstaele
keywords: emotionality; neuropeptide Y; rodent models; stress resilience; stress-related psychiatric disorders