title: Sweet syndrome with panniculitis, arthralgia, episcleritis, and neurologic involvement precipitated by antibiotics.
abstract: BACKGROUND
  Sweet syndrome is an uncommon skin condition, often idiopathic in origin although it may be reactive to various systemic conditions, recent infections, underlying malignancies, and medications.
  
  
  OBJECTIVE
  To present a case highlighting a rare clinical presentation and to review the causes of Sweet syndrome with an emphasis on drug-induced etiologies.
  
  
  RESULTS
  We describe a 45-year-old woman who developed Sweet syndrome while receiving nitrofurantoin and ciprofloxacin for a urinary tract infection. Her course of disease was complicated by arthralgias, episcleritis, headaches, and erythema nodosum-like subcutaneous involvement. There was marked improvement with discontinuation of the inciting antibiotics and initiation of systemic steroids.
  
  
  CONCLUSIONS
  This case illustrates Sweet syndrome related to nitrofurantoin and/or ciprofloxacin. This is the second report of Sweet syndrome related to these antibiotics and the first associated with ocular, joint, and neurologic involvement.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Kwok
authors.forename: Muhammad N
authors.initials: MN
authors.lastname: Mahmood
authors.affiliation: Divison of Dermatology and Cutaneous Sciences, Department of Medicine, University of Alberta. tsalopek@ualberta.ca.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Salopek
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced; D002939:Ciprofloxacin / Q000009:adverse effects*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009582:Nitrofurantoin / Q000009:adverse effects*; D015434:Panniculitis / Q000139:chemically induced; D015423:Scleritis / Q000139:chemically induced; D016463:Sweet Syndrome / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D002939:Ciprofloxacin; D009582:Nitrofurantoin