title: Influence of respiratory motion correction on quantification of myocardial perfusion SPECT.
abstract: BACKGROUND
  Respiratory-related cardiac motion could have considerable effects on myocardial perfusion imaging, leading to misinterpretation of the images. In this study, we examined the influence of respiratory correction on ECG-gated myocardial perfusion SPECT (RC-GSPECT) concerning regional myocardial perfusion and function.
  
  
  METHODS
  Using the NCAT phantom, a typical torso phantom was generated. SimSET, a Monte Carlo simulator, was used to image the photon emerging from the phantom. Twenty-six patients underwent a 2-day stress-rest ECG-gated myocardial perfusion SPECT (GSPECT) imaging. A separate study was also performed by simultaneous respiratory and cardiac triggering with the real-time position management (RPM) for respiratory correction (RC).
  
  
  RESULTS
  In simulation study, count density in the inferior and inferoseptal walls increased in the lower bin of the respiratory cycle. On the other hand, there was a higher correlation between RC-GSPECT and echocardiography for left ventricular ejection fraction (LVEF) (r = 0.95, P < .01 vs r = 0.88, P < .01 for GSPECT).
  
  
  CONCLUSIONS
  We proposed a new approach for respiratory and cardiac-gated SPECT to eliminate respiratory motion artifacts. RC-GSPECT is a feasible method in MPI studies and may play an important role to improve the quality of MPI images, particularly in the inferior wall.
authors.affiliation: Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran. bitarafan@hotmail.com.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bitarafan-Rajabi
authors.affiliation: Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Rajabi
authors.affiliation: Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran. monami_58@yahoo.co.uk.
authors.forename: Feridoon
authors.initials: F
authors.lastname: Rastgou
authors.affiliation: Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hasan
authors.initials: H
authors.lastname: Firoozabady
authors.affiliation: Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Yaghoobi
authors.affiliation: Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Malek
authors.affiliation: Department of Nuclear Medicine & Endocrinology, St Vincent's Hospital, PET - CT Center Linz, Seilerstaette 4, Linz, A-4020, Austria.
authors.forename: Werner
authors.initials: W
authors.lastname: Langesteger
authors.affiliation: Department of Nuclear Medicine & Endocrinology, St Vincent's Hospital, PET - CT Center Linz, Seilerstaette 4, Linz, A-4020, Austria.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Beheshti
mesh_terms: D000368:Aged; D016477:Artifacts; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D003198:Computer Simulation; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D009068:Movement; D055414:Myocardial Perfusion Imaging; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D012119:Respiration; D013667:Technetium / Q000737:chemistry; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium
keywords: 99mTc-tetrofosmin; gated SPECT; myocardial perfusion; respiratory correction