title: Idiopathic vitritis in the setting of Boston keratoprosthesis.
abstract: OBJECTIVE
  The aim of this study was to revisit the clinical paradigm attributed to Boston keratoprosthesis recipients presenting with idiopathic vitreous inflammation.
  
  
  METHODS
  A retrospective chart review was performed of keratoprosthesis recipients at Massachusetts Eye and Ear Infirmary, from January 2000 to August 2013, for demographic data, indication(s) for surgery, timing and presentation of vitreous inflammation, and best-corrected visual acuity at baseline, on presentation, and after resolution of vitritis.
  
  
  RESULTS
  Twenty-three (23 eyes) of 346 patients developed idiopathic vitreous inflammation after keratoprosthesis implantation. Six of 23 patients presented with signs and symptoms similar to infectious endophthalmitis but were culture negative. The proportion of patients who fit the previous paradigm of sudden painless loss of vision without external signs of infection ("sterile vitritis") at their first presentation with vitritis was only 4 of 23. Vision decline was variable (median, 9 lines on Snellen chart; range, 0-24), as was time to recovery of best vision (median, 8.9 weeks; range, 0.9-36.7). Nine eyes had repeat bouts (43 episodes in 23 patients). Ten of 43 episodes did not recover to baseline vision. Seventeen of 23 eyes with idiopathic vitritis after keratoprosthesis later developed other complications.
  
  
  CONCLUSIONS
  The current paradigm for idiopathic vitritis after keratoprosthesis implantation includes sudden painless loss of vision with full recovery of vision on treatment with periocular corticosteroids. However, idiopathic vitritis after keratoprosthesis can also mimic infectious endophthalmitis with pain and external signs of inflammation. Visual loss can be gradual. Vision may not recover to baseline despite treatment. Vitritis may be a part of a common pathway of chronic inflammation after keratoprosthesis.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Massachusetts Eye Infirmary, Boston, MA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Grassi
authors.forename: Alja
authors.initials: A
authors.lastname: Crnej
authors.forename: Eleftherios I
authors.initials: EI
authors.lastname: Paschalis
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Colby
authors.forename: Claes H
authors.initials: CH
authors.lastname: Dohlman
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001187:Artificial Organs; D003315:Cornea; D003316:Corneal Diseases / Q000601:surgery*; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019736:Prostheses and Implants; D012189:Retrospective Studies; D014822:Vitreous Body / Q000473:pathology*; D055815:Young Adult