title: Prognostic value of the dynamics of M-type phospholipase A2 receptor antibody titers in patients with idiopathic membranous nephropathy treated with two different immunosuppression regimens.
abstract: BACKGROUND
  The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy.
  
  
  OBJECTIVE
  We analyzed the predictive value of the dynamics of these antibodies on clinical responses.
  
  
  METHODS
  The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimens
  
  
  RESULTS
  In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses.
  
  
  CONCLUSIONS
  Antibody titer dynamics was useful for predicting clinical responses.
authors.affiliation: Department of Nephrology .
authors.forename: Alfonso Segarra
authors.initials: AS
authors.lastname: Medrano
authors.forename: Elias Jatem
authors.initials: EJ
authors.lastname: Escalante
authors.forename: Clara Carnicer
authors.initials: CC
authors.lastname: Cáceres
authors.forename: Irene Agraz
authors.initials: IA
authors.lastname: Pamplona
authors.forename: Maria Teresa Salcedo
authors.initials: MT
authors.lastname: Allende
authors.forename: Natalia Ramos
authors.initials: NR
authors.lastname: Terrades
authors.forename: Naiara Valtierra
authors.initials: NV
authors.lastname: Carmeno
authors.forename: Elena Ostos
authors.initials: EO
authors.lastname: Roldán
authors.forename: Karla Viviana Arredondo
authors.initials: KV
authors.lastname: Agudelo
authors.forename: Juliana Jaramillo
authors.initials: JJ
authors.lastname: Vasquez
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D054507:Receptors, Phospholipase A2 / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007166:Immunosuppressive Agents; D054507:Receptors, Phospholipase A2
keywords: Cyclophospamide; membranous nephropathy; renal disease; rituximab; type M phospholipase A2 antibodies