title: Cost-effectiveness and pricing of antibacterial drugs.
abstract: Growing resistance to antibacterial agents has increased the need for the development of new drugs to treat bacterial infections. Given increasing pressure on limited health budgets, it is important to study the cost-effectiveness of these drugs, as well as their safety and efficacy, to find out whether or not they provide value for money and should be reimbursed. In this article, we systematically reviewed 38 cost-effectiveness analyses of new antibacterial agents. Most studies showed the new antibacterial drugs were cost-effective compared to older generation drugs. Drug pricing is a complicated process, involving different stakeholders, and has a large influence on cost-effectiveness. Value-based pricing is a method to determine the price of a drug at which it can be cost-effective. It is currently unclear what the influence of value-based pricing will be on the prices of new antibacterial agents, but an important factor will be the definition of 'value', which as well as the impact of the drug on patient health might also include other factors such as wider social impact and the health impact of disease.
authors.affiliation: Department of Applied Health Research, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Talitha I
authors.initials: TI
authors.lastname: Verhoef
authors.forename: Stephen
authors.initials: S
authors.lastname: Morris
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics*; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D015195:Drug Design
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibacterial drugs; antibiotics; cost-effectiveness; health economics; value-based pricing