title: HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice.
abstract: BACKGROUND
  HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.
  
  
  METHODS
  The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.
  
  
  RESULTS
  The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.
  
  
  CONCLUSIONS
  Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.
authors.forename: Heon-Myung
authors.initials: HM
authors.lastname: Lee
authors.forename: Hong-Kun
authors.initials: HK
authors.lastname: Rim
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Seo
authors.forename: Yoon-Bum
authors.initials: YB
authors.lastname: Kook
authors.forename: Sung-Kew
authors.initials: SK
authors.lastname: Kim
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
authors.forename: Jong-Sik
authors.initials: JS
authors.lastname: Jin
authors.affiliation: Department of Pharmacology, College of Oriental Medicine, Sangji University, Wonju-si, Gangwon-do 220-702, Republic of Korea. hjan@sj.ac.kr.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: An
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004435:Eating / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D019684:Magnoliopsida; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D047495:PPAR gamma / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014157:Transcription Factors / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D022763:CCAAT-Enhancer-Binding Protein-alpha; D047495:PPAR gamma; D010936:Plant Extracts; D014157:Transcription Factors