title: [Pertussis trend in children under one year of age in the Czech Republic in 1997-2013].
abstract: OBJECTIVE
  To characterize the epidemiological situation of pertussis in children under one year of age in the Czech Republic in 1997-2013.
  
  
  METHODS
  The study cohort consisted of children under one year of age with laboratory confirmed pertussis reported to the communicable disease system from 1997 to 2013. A total of 265 pertussis cases were reported in children under one year of age over the study period. Selected demographic data, need for hospitalization, and vaccination history were evaluated in the study cohort.
  
  
  RESULTS
  Children under one year of age have shown a steady upward trend in reported cases of pertussis since the 1990s. The reported incidence of pertussis in this age group was the lowest in 1998 (1.1/100,000 population) and the highest in 2013 (31.3/100,000). In 1997-2013, 265 pertussis cases were reported in children under one year of age, 128 females and 137 males, to the communicable disease system in the Czech Republic. Most of these children, nearly 77%, developed pertussis within the first four months of life. Of the 265 children, 79% were not vaccinated before the onset of the disease and 21% were immunized with at least one dose of pertussis vaccine before developing the disease. As many as 75% of the children with pertussis needed hospitalization. Most of them, nearly 81%, were hospitalized with pertussis in the first four months of life and 90% of them in the first six months of life.
  
  
  CONCLUSIONS
  In 1997-2013, an upward trend was observed in pertussis cases in children under one year of age. Most children developed the disease within the first four months of life while not vaccinated against pertussis. This fact unambiguously supports the "cocoon" strategy, i.e. vaccination of the closest contacts of the child, and a booster dose at 25 years of age. At the same time, a question arises whether to provide vaccination to pregnant women.
authors.forename: K
authors.initials: K
authors.lastname: Fabiánová
authors.forename: H
authors.initials: H
authors.lastname: Šebestová
authors.forename: Č
authors.initials: Č
authors.lastname: Beneš
authors.forename: J
authors.initials: J
authors.lastname: Zavadilová
authors.forename: P
authors.initials: P
authors.lastname: Křížová
authors.forename: B
authors.initials: B
authors.lastname: Kříž
mesh_terms: D002648:Child; D002675:Child, Preschool; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage; D011247:Pregnancy; D014611:Vaccination; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine