title: Longitudinal quantification and visualization of intracerebral haemorrhage using multimodal magnetic resonance and diffusion tensor imaging.
abstract: OBJECTIVE
  To demonstrate a set of approaches using diffusion tensor imaging (DTI) tractography whereby pathology-affected white matter (WM) fibres in patients with intracerebral haemorrhage (ICH) can be selectively visualized.
  
  
  METHODS
  Using structural neuroimaging and DTI volumes acquired longitudinally from three representative patients with ICH, the spatial configuration of ICH-related trauma is delineated and the WM fibre bundles intersecting each ICH lesion are identified and visualized. Both the extent of ICH lesions as well as the proportion of WM fibres intersecting the ICH pathology are quantified and compared across subjects.
  
  
  RESULTS
  This method successfully demonstrates longitudinal volumetric differences in ICH lesion load and differences across time in the percentage of fibres which intersect the primary injury.
  
  
  CONCLUSIONS
  Because neurological conditions such as intracerebral haemorrhage (ICH) frequently exhibit pathology-related effects which lead to the exertion of mechanical pressure upon surrounding tissues and, thereby, to the deformation and/or displacement of WM fibres, DTI fibre tractography is highly suitable for assessing longitudinal changes in WM fibre integrity and mechanical displacement.
authors.affiliation: Institute for Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA .
authors.forename: S Y Matthew
authors.initials: SY
authors.lastname: Goh
authors.forename: Andrei
authors.initials: A
authors.lastname: Irimia
authors.forename: Carinna M
authors.initials: CM
authors.lastname: Torgerson
authors.forename: Meral A
authors.initials: MA
authors.lastname: Tubi
authors.forename: Courtney R
authors.initials: CR
authors.lastname: Real
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hanley
authors.forename: Neil A
authors.initials: NA
authors.lastname: Martin
authors.forename: Paul M
authors.initials: PM
authors.lastname: Vespa
authors.forename: John D
authors.initials: JD
authors.lastname: Van Horn
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D002543:Cerebral Hemorrhage / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D066127:White Matter / Q000473:pathology
keywords: Diffusion tensor imaging; intracerebral haemorrhage; longitudinal study; magnetic resonance imaging