title: [Effects of r-hGH replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature].
abstract: OBJECTIVE
  To study the effects of recombinant human growth hormone (r-hGH) replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature (ISS).
  
  
  METHODS
  Forty-seven ISS children with a mean age of 10±3 years treated between January 2009 and January 2013 were enrolled. All children underwent r-hGH replacement therapy for 3-24 months and were followed up once every 3 months. Fasting blood glucose (FBG), insulin (INS), blood lipids and thyroid function were measured before treatment and after 0-1 and 1-2 years of treatment.
  
  
  RESULTS
  After treatment with r-hGH, there were no significant changes in FBG, INS, insulin sensitivity index (ISI), and FBG/INS ratio (FGIR), but the FGIR showed a declining trend. The percentage of patients with FGIR<7 (a marker of insulin resistance) was 13% before treatment compared to 18% 1-2 years after treatment. The atherosclerosis index decreased after r-hGH treatment, but there were no significant changes in total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and BMI. Furthermore, no significant change in thyroid function was observed after r-hGH therapy.
  
  
  CONCLUSIONS
  r-hGH therapy can improve lipid metabolism, without significant impacts on thyroid function, FBG and INS. It seems to be a safe and reliable therapy for children with ISS. However, this therapy possibly reduces insulin sensitivity.
authors.affiliation: Peking University Third Hospital, Beijing 100191, China. xuemeiw7886@sohu.com.
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Zheng
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019382:Human Growth Hormone; D005947:Glucose