title: Medial prefrontal cortex dopamine controls the persistent storage of aversive memories.
abstract: Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus.
authors.affiliation: Laboratorio de Memoria, Facultad de Medicina, Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires-CONICET Buenos Aires, Argentina.
authors.forename: María C
authors.initials: MC
authors.lastname: Gonzalez
authors.affiliation: Laboratorio de Memoria, Facultad de Medicina, Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires-CONICET Buenos Aires, Argentina.
authors.forename: Cecilia P
authors.initials: CP
authors.lastname: Kramar
authors.affiliation: Laboratorio de Memoria, Facultad de Medicina, Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires-CONICET Buenos Aires, Argentina.
authors.forename: Micol
authors.initials: M
authors.lastname: Tomaiuolo
authors.affiliation: Laboratorio de Memoria, Facultad de Medicina, Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires-CONICET Buenos Aires, Argentina.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Katche
authors.affiliation: Grupo de Neurociencias de Sistemas, IFIBIO Houssay, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires Buenos Aires, Argentina.
authors.forename: Noelia
authors.initials: N
authors.lastname: Weisstaub
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte (UFRN) Natal, Brazil.
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
authors.affiliation: Laboratorio de Memoria, Facultad de Medicina, Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires-CONICET Buenos Aires, Argentina ; Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires Buenos Aires, Argentina.
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
keywords: D1/D5 receptor; VTA; conditioned taste aversion; inhibitory avoidance; system consolidation