title: Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide.
abstract: We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.
authors.affiliation: FIRST (Faculty of Frontiers of Innovative Research in Science and Technology), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Usui
authors.forename: Arisa
authors.initials: A
authors.lastname: Okada
authors.forename: Keita
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004789:Enzyme Activation; D005453:Fluorescence; D006147:Guanine / Q000737:chemistry / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D010447:Peptide Hydrolases / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020135:Peptide Nucleic Acids; D010455:Peptides; D006147:Guanine; D004247:DNA; D010447:Peptide Hydrolases