title: Ribosomopathies: mechanisms of disease.
abstract: Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information.
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Nakhoul
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA. ; Department of Laboratory Medicine, Jiangxi Children's Hospital, Nanchang, Jiangxi, China.
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Ke
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Liao
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA.
authors.forename: Shelya X
authors.initials: SX
authors.lastname: Zeng
authors.affiliation: Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University, School of Medicine, New Orleans, Louisiana, LA, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
keywords: 5q-syndrome; Diamond-Blackfan anemia (DBA); Schwachman-Diamond syndrome (SDS); Treacher Collins syndrome (TCS); cartilage hair hypoplasia (CHH); dyskeratosis congenita (DC); p53; ribosomopathy