title: [Histoplasmosis of the central nervous system in an immunocompetent patient].
abstract: Histoplasmosis is a multifaceted condition caused by the dimorphic fungi Histoplasma capsulatum whose infective spores are inhaled and reach the lungs, the primary organ of infection. The meningeal form, considered one of the most serious manifestations of this mycosis, is usually seen in individuals with impaired cellular immunity such as patients with acquired immunodeficiency syndrome, systemic lupus erythematous or solid organ transplantation, and infants given their immunological immaturity. The most common presentation is self-limited and occurs in immunocompetent individuals who have been exposed to high concentrations of conidia and mycelia fragments of the fungi. In those people, the condition is manifested by pulmonary disorders and late dissemination to other organs and systems. We report a case of central nervous system histoplasmosis in an immunocompetent child.
authors.affiliation: Servicio de Pediatría, Hospital General de Medellín, Medellín, Colombia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Osorio
authors.affiliation: Facultad de Medicina, Universidad CES, Medellín, Colombia.
authors.forename: Yúrika
authors.initials: Y
authors.lastname: López
authors.affiliation: Servicio de Pediatría, Hospital General de Medellín, Medellín, Colombia.
authors.forename: Juan Camilo
authors.initials: JC
authors.lastname: Jaramillo
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D020878:Device Removal; D003951:Diagnostic Errors; D006261:Headache / Q000209:etiology; D006658:Histoplasma / Q000276:immunology / Q000302:isolation & purification; D006659:Histoplasmin / Q000097:blood / Q000134:cerebrospinal fluid; D006660:Histoplasmosis / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D007008:Hypokalemia / Q000209:etiology; D007121:Immunocompetence; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D016921:Meningitis, Fungal / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008881:Migraine Disorders / Q000175:diagnosis; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000209:etiology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D020713:Vancomycin Resistance; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B; D006659:Histoplasmin