title: Precision and neuronal dynamics in the human posterior parietal cortex during evidence accumulation.
abstract: Primate studies show slow ramping activity in posterior parietal cortex (PPC) neurons during perceptual decision-making. These findings have inspired a rich theoretical literature to account for this activity. These accounts are largely unrelated to Bayesian theories of perception and predictive coding, a related formulation of perceptual inference in the cortical hierarchy. Here, we tested a key prediction of such hierarchical inference, namely that the estimated precision (reliability) of information ascending the cortical hierarchy plays a key role in determining both the speed of decision-making and the rate of increase of PPC activity. Using dynamic causal modelling of magnetoencephalographic (MEG) evoked responses, recorded during a simple perceptual decision-making task, we recover ramping-activity from an anatomically and functionally plausible network of regions, including early visual cortex, the middle temporal area (MT) and PPC. Precision, as reflected by the gain on pyramidal cell activity, was strongly correlated with both the speed of decision making and the slope of PPC ramping activity. Our findings indicate that the dynamics of neuronal activity in the human PPC during perceptual decision-making recapitulate those observed in the macaque, and in so doing we link observations from primate electrophysiology and human choice behaviour. Moreover, the synaptic gain control modulating these dynamics is consistent with predictive coding formulations of evidence accumulation.
authors.affiliation: Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, UK. Electronic address: thomas.fitzgerald@ucl.ac.uk.
authors.forename: Thomas H B
authors.initials: THB
authors.lastname: FitzGerald
authors.affiliation: Virginia Tech Carilion Research Institute, Roanoke, VA, USA; Bradley Department of Electrical & Computer Engineering, Roanoke, VA, USA.
authors.forename: Rosalyn J
authors.initials: RJ
authors.lastname: Moran
authors.affiliation: Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, UK.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Friston
authors.affiliation: Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, UK.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
mesh_terms: D000328:Adult; D003657:Decision Making / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000166:cytology / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult