title: Perfluorooctanoic acid binds to peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation in 3T3-L1 adipocytes.
abstract: We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest that PFOA promotes adipocyte differentiation as a PPAR γ ligand.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Junpei
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D002210:Caprylates / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D005466:Fluorocarbons / Q000494:pharmacology*; D051275:Glucose Transporter Type 4 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D008024:Ligands; D051379:Mice; D047495:PPAR gamma / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D012333:RNA, Messenger / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C530718:CEBPA protein, mouse; D002210:Caprylates; D005466:Fluorocarbons; D051275:Glucose Transporter Type 4; D008024:Ligands; D047495:PPAR gamma; D012333:RNA, Messenger; C495693:Slc2a4 protein, mouse; D014280:Triglycerides; C023036:perfluorooctanoic acid
keywords: 3T3-L1 adipocyte; adipocyte differentiation; perfluorooctanoic acid; peroxisome proliferator-activated receptor γ