title: Tumors STING adaptive antitumor immunity.
abstract: Immunotherapy is revolutionizing the treatment of cancer patients, but the molecular basis for tumor immunogenicity is unclear. In this issue of Immunity, Deng et al. (2014) and Woo et al. (2014) provide evidence suggesting that dendritic cells detect DNA from tumor cells via the STING-mediated, cytosolic DNA sensing pathway.
authors.affiliation: Verona University Hospital and Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy. Electronic address: vincenzo.bronte@univr.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bronte
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008546:Melanoma, Experimental / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology*; D009369:Neoplasms / Q000532:radiotherapy*; D009713:Nucleotidyltransferases / Q000276:immunology*; D000099197:STING Protein; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
chemical_list: D004247:DNA; D008565:Membrane Proteins; D009713:Nucleotidyltransferases; C530855:Sting1 protein, mouse; D000099197:STING Protein; C578391:cGAS protein, mouse; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase