title: Oxidative stress and inflammatory signaling in cerulein pancreatitis.
abstract: Oxidative stress is considered to be an important regulator of the pathogenesis of acute pancreatitis. Reactive oxygen species (ROS) regulate the activation of inflammatory cascades, the recruitment of inflammatory cells and tissue damage in acute pancreatitis. A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression, which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinases (MAPKs). Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB, AP-1, STAT3, and MAPKs; this crosstalk amplifies the inflammatory cascade in acute pancreatitis. Therapeutic studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-induced pancreatitis. Since oxidative stress may activate inflammatory signaling pathways and contribute to the development of pancreatitis, antioxidant therapy may alleviate the symptoms or prevent the development of pancreatitis. Since chronic administration of high doses of antioxidants may have deleterious effects, dosage levels and duration of antioxidant treatment should be carefully determined.
authors.affiliation: Ji Hoon Yu, New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 701-310, South Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Yu
authors.affiliation: Ji Hoon Yu, New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 701-310, South Korea.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002108:Ceruletide; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D002108:Ceruletide
keywords: Cerulein pancreatitis; Inflammatory signaling; Reactive oxygen species