title: Adenosine deaminase, dipeptidyl peptidase-IV activities and lipid peroxidation are increased in the saliva of obese young adult.
abstract: BACKGROUND
  Obesity is the hallmark of the metabolic syndrome representing a major global health problem. It is considered a state of chronic inflammation with minimal exploration of salivary biomarkers. Thus, the intent of the present study was to assess the activities of salivary dipeptidyl peptidase IV (DPP-IV), adenosine deaminase (ADA) and lipid peroxidation in obese young and overweight young subjects.
  
  
  METHODS
  ADA, DPP-IV activities and lipid peroxidation were investigated in saliva, as well as insulin, glucose, HbA1c, HOMA and anthropometric measurements in 149 young adults, including 54 with normal weight, 27 overweight and 68 obese subjects.
  
  
  RESULTS
  Salivary ADA and DPP-IV activities as well as lipid peroxidation were higher in patients with obesity compared to the normal weight group. Correlations between ADA/DPP-IV activities, lipid peroxidation/ADA activity, ADA activity/hip circumference and BMI/weight were observed.
  
  
  CONCLUSIONS
  Our results indicate that the increase in the salivary ADA and DPP-IV activities as well as in the lipid peroxidation could be related of the regulation to various aspects of adipose tissue function and inflammatory obesity. It is suggested that these salivary biomarkers may be used as biochemical test in clinical abnormalities present in obesity, in the absence of oral inflammatory diseases.
authors.forename: Eduardo Ottobelli
authors.initials: EO
authors.lastname: Chielle
authors.forename: Gabriela
authors.initials: G
authors.lastname: Bonfanti
authors.forename: Karine Santos
authors.initials: KS
authors.lastname: De Bona
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Moretto
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015227:Lipid Peroxidation; D008297:Male; D009765:Obesity / Q000201:enzymology / Q000378:metabolism*; D012463:Saliva / Q000201:enzymology*; D055815:Young Adult
chemical_list: D018819:Dipeptidyl Peptidase 4; D000243:Adenosine Deaminase