title: Jasmine flower extract lowers prolactin.
abstract: BACKGROUND
  Antipsychotic drugs frequently cause amenorrhoea and galactorrhoea. Jasmine flowers used topically were as effective as oral Bromocriptine in suppressing puerperal lactation. This study aims to evaluate the efficacy and safety of intranasal jasmine flower extract (JFE) to reduce prolactin levels of patients on stable doses of antipsychotic drugs.
  
  
  METHODS
  This is a randomized, double blind, crossover clinical trial. An aqueous-ethanol extract of jasmine flowers was prepared and used as nasal drops. A decrease in serum prolactin of ≥25 ng/mL was considered a significant response.
  
  
  RESULTS
  Ten out of 35 women had a significant drop in the serum prolactin while on the JFE. The non-responders to JFE were on higher doses of antipsychotic drugs. The main side effect was a transient and mild burning sensation in the nose. A cost analysis favoured JFE over dopamine agonists.
  
  
  CONCLUSIONS
  JFE contains a prolactin-lowering substance which needs further characterisation.
authors.affiliation: Registrar, Department of Endocrinology, Christian Medical College, Vellore, India philip.finny@gmail.com.
authors.forename: Philip
authors.initials: P
authors.lastname: Finny
authors.affiliation: Lecturer, Department of Biochemistry, Christian Medical College, Vellore, India.
authors.forename: Charles
authors.initials: C
authors.lastname: Stephen
authors.affiliation: Lecturer, Department of Psychiatry, Christian Medical College, Vellore, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Jacob
authors.affiliation: Professor, Department of Psychiatry, Christian Medical College, Vellore, India.
authors.forename: Prathap
authors.initials: P
authors.lastname: Tharyan
authors.affiliation: Professor, Department of Endocrinology, Christian Medical College, Vellore, India.
authors.forename: Mandalam S
authors.initials: MS
authors.lastname: Seshadri
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001971:Bromocriptine / Q000009:adverse effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D035264:Flowers; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D031660:Jasminum; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D049590:Postpartum Period; D011388:Prolactin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D010936:Plant Extracts; D001971:Bromocriptine; D011388:Prolactin
keywords: Jasmine flower extract; antipsychotic medication; hyperprolactinaemia