title: ESC-derived retinal pigmented epithelial cell transplants in patients: so far, so good.
abstract: Many untreatable blinding diseases involve degeneration of retinal pigmented epithelial (RPE) cells, which has prompted exploration of the therapeutic potential of human-pluripotent-stem-cell-derived RPE. The first safety trials reported in The Lancet of embryonic-stem-cell-derived RPE cell transplants indicate no serious adverse outcomes and encourage further investigation.
authors.affiliation: Stem Cells and Regenerative Medicine Section, UCL Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: j.sowden@ucl.ac.uk.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Sowden
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000637:transplantation*; D006801:Humans; D055213:Retinal Pigment Epithelium / Q000166:cytology*; D033581:Stem Cell Transplantation; D041623:Tomography, Optical Coherence; D014183:Transplantation, Heterologous; D014792:Visual Acuity