title: The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection.
abstract: Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.
authors.forename: Q G
authors.initials: QG
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Wei
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: L J
authors.initials: LJ
authors.lastname: Chen
authors.forename: Y Y
authors.initials: YY
authors.lastname: Liu
authors.forename: F
authors.initials: F
authors.lastname: Luo
authors.forename: H R
authors.initials: HR
authors.lastname: Xiong
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Yang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology*; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D028502:Polygonum / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts