title: Subergorgiaols A-L, 9,10-secosteroids from the South China Sea gorgonian Subergorgia rubra.
abstract: Twelve new 9,10-secosteroids designated as subergorgiaols A-L (1-12), along with four known analogues (13-16), were isolated from the gorgonian Subergorgia rubra collected from the South China Sea. Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods including NOESY spectra. The absolute configuration of 1 was established by a dimolybdenum tetraacetate [Mo2(AcO)4] induced circular dichroism (ICD) procedure and the modified Mosher's method. Compounds 1-12 represent the first series of 9,10-secosteroids characterized with a hydroxy group at C-8, which are 8-OH derivatives of astrogorgiadiols/calicoferols. Compound 4 exhibited cytotoxicity against the cervical carcinoma cell line (CaSki) with an IC50 value of 2.4 μM, and 6 showed toxicity toward brine shrimp Artemia salina with an LC50 value of 2.0 μM.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Guangxi Key Laboratory of Marine Biotechnology, Guangxi Institute of Oceanology, Beihai 536000, China.
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Sun
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Guangxi Key Laboratory of Marine Biotechnology, Guangxi Institute of Oceanology, Beihai 536000, China.
authors.forename: Hai-Juan
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China. Electronic address: changyun@ouc.edu.cn.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D002681:China; D002850:Chromatography, Gel; D002942:Circular Dichroism; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009792:Oceans and Seas; D012632:Secosteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D012632:Secosteroids
keywords: 9,10-Secosteroids; Cytotoxicity; Subergorgia rubra; Subergorgiaols A–L