title: Non-invasive biomarkers in non-alcoholic steatohepatitis-induced hepatocellular carcinoma.
abstract: Non-alcoholic fatty liver disease (NAFLD) is by far the most common form of chronic liver disease worldwide, affecting adults as well as children. Under the term of NAFLD there is a wide spectrum of diseases ranging from simple steatosis to the non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma (HCC). Several mechanisms have been described to influence the progression of the disease from the benign NAFL to the aggressive NASH. The imbalance between pro- and anti-oxidant mechanisms and between pro- and anti-inflammatory cytokines is thought to play a pivotal role in the pathogenesis of NAFLD and disease progression toward NASH and fibrosis. The present review intends to look at some of the mechanistic biomarkers to be employed in establishing an early diagnosis in HCC derived from NASH.
authors.affiliation: Division of Nephrology and Internal Medicine, Fundeni Clinical Institute and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Voiculescu
authors.affiliation: In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Radu M
authors.initials: RM
authors.lastname: Nanau
authors.affiliation: In Vitro Drug Safety and Biotechnology,Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. manuela.neuman@utoronto.ca.
authors.forename: Manuela G
authors.initials: MG
authors.lastname: Neuman
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D020869:Gene Expression Profiling; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D055432:Metabolomics; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor