title: Predictors of success in selective laser trabeculoplasty for normal tension glaucoma.
abstract: To determine the predictors of success for selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG). This prospective cohort study recruited subjects with unilateral or bilateral NTG on medication. All subjects received a single session of 360° SLT treatment. SLT success was defined as IOP reduction≥20% at 1-month. The following covariates were analyzed via univariate and multivariate analyses: age; sex; lens status; presenting, pre-SLT, and post-SLT IOP's; number and type of medications; SLT shots and energy; and pre-SLT investigations. In 60 eyes of 32 subjects with NTG, there were 30 right eyes and 28 left eyes. The success rate of SLT was 61.7%. Using 3 types of anti-glaucoma medications (coefficient=-2.2, OR=0.1, P=0.02) and a thicker retinal nerve fiber layer thickness (coefficient=-0.04, OR=0.96, P=0.04) were associated with failure (univariate analysis). In multivariate analysis, a higher pre-SLT IOP (coefficient=1.1, OR=3.1, P=0.05) and a lower 1-week IOP (coefficient=-0.8, OR=0.5, P=0.04) were associated with success. SLT was successful in over 60% of treated NTG patients. A higher pre-SLT IOP and a greater IOP reduction at 1-week post-SLT were predictors of a successful outcome.
authors.affiliation: From the Department of Ophthalmology, Caritas Medical Centre, (JWYL); The Department of Ophthalmology, The University of Hong Kong, (JWYL, JSML); Department of Applied Mathematics, The Hong Kong Polytechnic University (CCLL); and The Department of Ophthalmology, Queen Mary Hospital, Hong Kong, SAR, People's Republic of China (JCHC).
authors.forename: Jacky W Y
authors.initials: JWY
authors.lastname: Lee
authors.forename: Catherine C L
authors.initials: CCL
authors.lastname: Liu
authors.forename: Jonathan C H
authors.initials: JCH
authors.lastname: Chan
authors.forename: Jimmy S M
authors.initials: JSM
authors.lastname: Lai
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D053685:Laser Therapy / Q000379:methods*; D057066:Low Tension Glaucoma / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity