title: The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo.
authors.affiliation: Skin Research Laboratory, Faculty of Medicine, Technion - Israel Institute of Technology, Flieman Medical Center, PO Box 9649, Haifa, Israel.
authors.forename: Aviad
authors.initials: A
authors.lastname: Keren
authors.affiliation: Skin Research Laboratory, Faculty of Medicine, Technion - Israel Institute of Technology, Flieman Medical Center, PO Box 9649, Haifa, Israel.
authors.forename: Avner
authors.initials: A
authors.lastname: Shemer
authors.affiliation: Skin Research Laboratory, Faculty of Medicine, Technion - Israel Institute of Technology, Flieman Medical Center, PO Box 9649, Haifa, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ullmann
authors.affiliation: Centre for Dermatology Research, Inst. of Inflammation and Repair, University of Manchester, Manchester, UK; Department of Dermatology, University of Münster, Münster, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Paus
authors.affiliation: Skin Research Laboratory, Faculty of Medicine, Technion - Israel Institute of Technology, Flieman Medical Center, PO Box 9649, Haifa, Israel. Electronic address: amos.gilhar@flim.health.gov.il.
authors.forename: Amos
authors.initials: A
authors.lastname: Gilhar
mesh_terms: D000506:Alopecia Areata / Q000188:drug therapy* / Q000276:immunology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000166:cytology; D008024:Ligands; D051379:Mice; D016513:Mice, SCID; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism; D058988:Phosphodiesterase 4 Inhibitors / Q000737:chemistry*; D010865:Pilot Projects; D012867:Skin / Q000378:metabolism*; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C527085:KLRK1 protein, human; C527086:Klrk1 protein, mouse; D008024:Ligands; D055655:NK Cell Lectin-Like Receptor Subfamily K; D058988:Phosphodiesterase 4 Inhibitors; D013792:Thalidomide; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C505730:apremilast