title: MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: results from a single centre.
abstract: OBJECTIVE
  To assess the technical and clinical results of MRgFUS treatment and factors affecting clinical treatment success.
  
  
  METHODS
  A total of 252 women (mean age, 42.1 ± 6.9 years) with uterine fibroids underwent MRgFUS. All patients underwent MRI before treatment. Results were evaluated with respect to post-treatment nonperfused volume (NPV), symptom severity score (SSS), reintervention rate, pregnancy and safety data.
  
  
  RESULTS
  NPV ratio was significantly higher in fibroids characterized by low signal intensity in contrast-enhanced T1-weighted fat saturated MR images and in fibroids distant from the spine (>3 cm). NPV ratio was lower in fibroids with septations, with subserosal component and in skin-distant fibroids (p < 0.001). NPV ratio was highly correlated with clinical success: NPV of more than 80 % resulted in clinical success in more than 80 % of patients. Reintervention rate was 12.7 % (mean follow-up time, 19.4 ± 8 months; range, 3-38). Expulsion of fibroids (21 %) was significantly correlated with a high clinical success rate. No severe adverse events were reported.
  
  
  CONCLUSIONS
  Adequate patient selection and correct treatment techniques, based on the learning curve of this technology, combined with technical advances of the system, lead to higher clinical success rates with low complications rate, comparable to other uterine-sparing treatment options.
  
  
  CONCLUSIONS
  • MRgFUS appears to be a valid alternative to other uterus-preserving therapies • Patient selection is a significant factor in achieving high NPV ratios • MRI screening parameters correlate with the amount of fibroid ablation in MRgFUS • NPV results of more than 80 % correlate with higher clinical success rates.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Helios-Amper Klinikum Dachau, Dachau, Helios-Amper Klinikum Dachau, Krankenhausstr. 15, 85221, Dachau, Germany, Irene.Mindjuk@helios-kliniken.de.
authors.forename: Irene
authors.initials: I
authors.lastname: Mindjuk
authors.forename: Christoph G
authors.initials: CG
authors.lastname: Trumm
authors.forename: Peter
authors.initials: P
authors.lastname: Herzog
authors.forename: Robert
authors.initials: R
authors.lastname: Stahl
authors.forename: Matthias
authors.initials: M
authors.lastname: Matzko
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement; D007889:Leiomyoma / Q000601:surgery*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D003287:Contrast Media; D005682:Gadolinium