title: Caught in the Act: R-loops are cleaved by structure-specific endonucleases to generate DSBs.
abstract: Unscheduled RNA-DNA hybrids promote the formation DNA double-strand breaks (DSBs) through poorly characterized mechanism. In this issue, Sollier et al. (2014) show that R-loops are processed by XPF and XPG, two structure-specific endonucleases of the NER pathway, to generate DSBs.
authors.affiliation: Institute of Human Genetics, CNRS-UPR 1142, Montpellier, France.
authors.forename: Yea-Lih
authors.initials: YL
authors.lastname: Lin
authors.affiliation: Institute of Human Genetics, CNRS-UPR 1142, Montpellier, France. Electronic address: ppasero@igh.cnrs.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pasero
mesh_terms: D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans