title: An update on the role of adipokines in arterial stiffness and hypertension.
abstract: Adipokines are hormones produced by adipocytes and have been involved in multiple pathologic pathways, including inflammatory and cardiovascular complications in essential hypertension. Arterial stiffness is a frequent vascular complication that represents increased cardiovascular risk in hypertensive patients. Adipokines, such as adiponectin, leptin and resistin, might be implicated in hypertension, as well as in vascular alterations associated with this condition. Arterial stiffness has proven to be a predictor of cardiovascular events. Obesity and target-organ damage such as arterial stiffness are features associated with hypertension. This review aims to update the association between adipokines and arterial stiffness in essential and resistant hypertension (RHTN).
authors.affiliation: aDepartment of Pharmacology, Faculty of Medical Sciences University of Campinas - UNICAMP, Campinas, SP, Brazil bPharmacology Department and INSERM U970 Hospital Europeen Georges Pompidou, Assistance-Publique Hopitaux de Paris, Paris-Derscartes University, Paris, France.
authors.forename: Andréa R
authors.initials: AR
authors.lastname: Sabbatini
authors.forename: Vanessa
authors.initials: V
authors.lastname: Fontana
authors.forename: Stephane
authors.initials: S
authors.lastname: Laurent
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000502:physiology; D052242:Adiponectin / Q000097:blood*; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000150:complications; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin