title: Genetic and immunologic relationships between vaccine and field strains for vaccine selection of type A foot-and-mouth disease virus circulating in East Asia.
abstract: Of the seven known serotypes of foot-and-mouth disease virus (FMDV), type A has the most diverse variations. Genetic variations also occur frequently at VP1, VP2, VP3, and VP4 because these proteins constitute the viral capsid. The structural proteins of FMDV, which are closely related to immunologic correlations, are the most easily analyzed because they have highly accessible information. In this study we analyzed the type A vaccine viruses by alignment of available sequences in order to find appropriate vaccine strains. The matching rate of ASIA topotype-specific sites (20 amino acids) located on the viral surface, which are mainly VP1 and VP2, was highly related to immunologic reactivity. Among the available vaccines analyzed in this study, we suggest that A Malaysia 97 could be used as a vaccine virus as it has the highest genetic similarity and immunologic aspects to field strains originating in East Asia.
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea; Veterinary College, Chungnam National University, Yuseonggu, Daejeon, 305-764, Republic of Korea.
authors.forename: Seo-Yong
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea; Veterinary College, Chungnam National University, Yuseonggu, Daejeon, 305-764, Republic of Korea.
authors.forename: Min-Eun
authors.initials: ME
authors.lastname: Park
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea.
authors.forename: Rae-Hyung
authors.initials: RH
authors.lastname: Kim
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea.
authors.forename: Mi-Kyeong
authors.initials: MK
authors.lastname: Ko
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea.
authors.forename: Kwang-Nyeong
authors.initials: KN
authors.lastname: Lee
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea.
authors.forename: Su-Mi
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Gyeonggi Province Veterinary Service Center, Anseong-si, Gyeonggi-do, 456-823, Republic of Korea.
authors.forename: Hang-Sub
authors.initials: HS
authors.lastname: Shim
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea.
authors.forename: Byounghan
authors.initials: B
authors.lastname: Kim
authors.affiliation: Veterinary College, Chungnam National University, Yuseonggu, Daejeon, 305-764, Republic of Korea.
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido, 430-757, Republic of Korea. Electronic address: parkjhvet@korea.kr.
authors.forename: Jong-Hyeon
authors.initials: JH
authors.lastname: Park
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D005202:Asia, Eastern; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D014644:Genetic Variation; D012367:RNA, Viral / Q000235:genetics; D016415:Sequence Alignment; D015678:Viral Structural Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral; D015678:Viral Structural Proteins; D014765:Viral Vaccines
keywords: A type; East Asia; FMD; Vaccine