title: Animal models of tuberculosis: Guinea pigs.
abstract: The progression of the disease that follows infection of guinea pigs with Mycobacterium tuberculosis displays many features of human tuberculosis (TB), and the guinea pig model of TB has been used for more than 100 years as a research tool to understand and describe disease mechanisms. Changes in the bacterial burden and pathology following infection can be readily monitored and used to evaluate the impact of TB interventions. Demonstration of the protective efficacy of vaccines in the low-dose aerosol guinea pig model is an important component of the preclinical data package for novel vaccines in development, and there is a continual need to improve the model to facilitate progression of vaccines to the clinic. Development of better tools with which to dissect the immune responses of guinea pigs is a focus of current research.
authors.affiliation: Microbiology Services, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
authors.forename: Simon
authors.initials: S
authors.lastname: Clark
authors.affiliation: Microbiology Services, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
authors.forename: Yper
authors.initials: Y
authors.lastname: Hall
authors.affiliation: Microbiology Services, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
authors.forename: Ann
authors.initials: A
authors.lastname: Williams
mesh_terms: D000818:Animals; D001500:BCG Vaccine; D004195:Disease Models, Animal; D006168:Guinea Pigs; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology*; D032581:Tuberculosis Vaccines / Q000276:immunology*
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines