title: [Advance in studies on antitumor and immunomodulatory effects of wogonin].
abstract: Wogonin is a kind of natural flavonoid compound. According to findings in the latest studies, wogonin shows a wide range of antitumor effects, with the characteristics of multi-pathway, multi-link and multi-target, such as promoting tumor cell apoptosis through ROS or Ca(2+)-mediated signal paths, enhancing tumor cytotoxicity by TNF-α and TRAIL, blocking tumor cell cycle, inhibiting tumor angiogenesis and resisting cancer synergistically with chemotherapeutic drugs. Moreover, Wogonin could enhance body immune function by enhancing immune cell infiltration, regulating the immune cell phenotype and promoting relevant cytokine secretion. In this paper, the authors summarized the advance in studies on wogonin's antitumor and immunomodulatory effects.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Xiao
authors.forename: Ping
authors.initials: P
authors.lastname: Bu
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Gong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D044950:Flavanones / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D007155:Immunologic Factors; D014409:Tumor Necrosis Factor-alpha; C085514:wogonin