title: Risk factors for retinopathy of prematurity in extremely preterm Chinese infants.
abstract: To investigate the incidence and risk factors of retinopathy of prematurity (ROP) and Type 1 ROP in extremely preterm Chinese infants. A retrospective review of medical records was performed of all extremely preterm neonates (gestational age, GA≤28 weeks) screened for ROP from 2007 to 2012 at an ophthalmology centre in Hong Kong. Thirty-three maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP. The mean gestational age (GA) was 26.4±1.3 weeks and the birth weight (BW) was 855.0±199.0 g. The incidence of ROP development was 60.7% and 16.2% for Type 1 ROP. On univariate analysis, 6 risk factors were identified for ROP development including: lighter BW; lower GA; postnatal hypotension; inotrope use; surfactant use; and invasive mechanical ventilation (all P≤0.01). On multivariate analysis, neonatal congenital heart disease and greater GA were protective factors for ROP development (P≤0.04). On the other hand, 4 risk factors were associated with Type 1 ROP development in univariate analysis, including: lower GA, lighter BW, multiple pregnancies, and invasive mechanical ventilation (all P≤0.02); while there was no significant risk factors on multivariate analysis. A lighter BW and lower GA were the only common independent risk factors for both ROP and Type 1 ROP while neonatal congenital heart disease and greater GA were the protective factors against ROP.
authors.affiliation: From the Department of Ophthalmology, Caritas Medical Centre (GSKY, JWYL, VTYT); Department of Ophthalmology, The University of Hong Kong (JWYL, IYHW); Department of Applied Mathematics, The Hong Kong Polytechnic University, Hong Kong SAR, People's Republic of China (CCLL).
authors.forename: Gordon S K
authors.initials: GSK
authors.lastname: Yau
authors.forename: Jacky W Y
authors.initials: JWY
authors.lastname: Lee
authors.forename: Victor T Y
authors.initials: VTY
authors.lastname: Tam
authors.forename: Catherine C L
authors.initials: CCL
authors.lastname: Liu
authors.forename: Ian Y H
authors.initials: IYH
authors.lastname: Wong
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008297:Male; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors