title: [Diagnosis and treatment of lichen sclerosus--review].
abstract: Lichen sclerosus (LS) is a chronic skin disease of the vulva which affects mostly women in the postmenopausal period. The disease affects also men and children. Its frequency is from 1/70 up to 1/1000, whereas for women it is 10 times more frequently. The disease has unknown etiology. Due to the high frequency of accompanying, autoimmune diseases, it is presumed that this disease is a result of immunological processes. Some of patients diagnosed with LS have vulvar intraepithelial neoplasia, while 0.3% - 4.9% of them have squamous cell carcinoma. The aim of this review is to summarize our knowledge regarding the frequency, clinical features, diagnosis and therapy of LS in view of the prevention of the complications that may occur.
  
  
  METHODS
  We researched the available literature and Medline on the topic for the period of 1971 until 2014 year. We summarized the most interesting, contemporary and scientifically substantiated facts regarding this disease.
  
  
  CONCLUSIONS
  Early diagnosis, the proper and timely treatment, as well as the continuous follow up the patients with LS is mandatory due to the fact that the spontaneous remission is extremely rare and the complications may lead to significant deterioration of the quality of life.
authors.forename: A
authors.initials: A
authors.lastname: Ganovska
authors.forename: S
authors.initials: S
authors.lastname: Kovachev
authors.forename: A
authors.initials: A
authors.lastname: Nikolov
mesh_terms: D002278:Carcinoma in Situ / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000150:complications; D005260:Female; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D011379:Prognosis; D014844:Vulva / Q000473:pathology*; D007724:Vulvar Lichen Sclerosus / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D014846:Vulvar Neoplasms / Q000150:complications