title: Increased vascular endothelial growth factor level in the subretinal fluid of eye with vasoproliferative retinal tumors.
abstract: OBJECTIVE
  To describe a level of vascular endothelial growth factor (VEGF) in the subretinal fluid obtained from a case with vasoproliferative retinal tumors (VPRTs).
  
  
  METHODS
  A 30-year-old male patient presented with VPRTs subsequent to long-standing rhegmatogenous retinal detachment.
  
  
  RESULTS
  The patient was treated with encircling scleral buckling, cryopexy, and intravitreal bevacizumab injection. The protein level of VEGF in the subretinal fluid was measured and compared with those in the subretinal fluid obtained from patients with rhegmatogenous retinal detachment. Vascular endothelial growth factor level in the subretinal fluid from a patient with VPRTs was 12,997.9 pg/mL, whereas the mean VEGF concentration in the subretinal fluid from 4 patients with rhegmatogenous retinal detachment was 2.1 ± 2.8 pg/mL.
  
  
  CONCLUSIONS
  The current data provide the evidence that VEGF production has increased in eyes with VPRTs and anti-VEGF therapy is theoretically effective for the treatment of VPRTs.
authors.affiliation: *Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; and †Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Fujiya
authors.forename: Kousuke
authors.initials: K
authors.lastname: Noda
authors.forename: Shiho
authors.initials: S
authors.lastname: Yoshida
authors.forename: Wataru
authors.initials: W
authors.lastname: Saito
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D019572:Retinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D058471:Subretinal Fluid / Q000737:chemistry*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014792:Visual Acuity
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A