title: Anti-inflammatory and antifibrotic effects of resveratrol in the lung.
abstract: Resveratrol, a natural polyphenolic molecule with several biological activities, is a well recognized anti-oxidant, anti-aging and cancer chemopreventive agent. Moreover, resveratrol anti-inflammatory and antifibrotic properties have been demonstrated both in vitro and in different animal models of inflammatory pathologies, including bowel and liver diseases. We review the evidence of resveratrol protective role in respiratory diseases such as acute lung injury, asthma, chronic obstructive pulmonary disease and lung fibrosis. We conclude that resveratrol and its derivatives may act as a therapeutic agents in respiratory diseases and pertinent clinical trials should be performed.
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy. econte@unict.it.
authors.forename: Enrico
authors.initials: E
authors.lastname: Conte
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
authors.forename: Evelina
authors.initials: E
authors.lastname: Fagone
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
authors.forename: Mary
authors.initials: M
authors.lastname: Fruciano
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Gili
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Iemmolo
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Vancheri
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005355:Fibrosis / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy; D008168:Lung / Q000187:drug effects; D051379:Mice; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000503:physiopathology; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol