title: Access to large cyclic peptides by a one-pot two-peptide segment ligation/cyclization process.
abstract: The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.
authors.affiliation: UMR CNRS 8161, Université de Lille, Pasteur Institute of Lille 59021 Lille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boll
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ebran
authors.forename: Hervé
authors.initials: H
authors.lastname: Drobecq
authors.forename: Ouafâa
authors.initials: O
authors.lastname: El-Mahdi
authors.forename: Laurent
authors.initials: L
authors.lastname: Raibaut
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ollivier
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D003500:Cyclization; D003545:Cysteine / Q000737:chemistry; D008026:Ligation; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D053778:Thiazolidines / Q000737:chemistry
chemical_list: D010456:Peptides, Cyclic; D053778:Thiazolidines; D003545:Cysteine