title: N-Acetylcysteine (NAC) inhibits renal nitrite and nitrate reabsorption in healthy subjects and in patients undergoing cardiac surgery: risk of nitric oxide (NO) bioavailability loss by NAC?
authors.affiliation: Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Electronic address: Tsikas.dimitros@mh-hannover.de.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tsikas
authors.affiliation: Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.
authors.forename: Jonas
authors.initials: J
authors.lastname: Niemann
authors.affiliation: Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Flentje
authors.affiliation: Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schwarz
authors.affiliation: Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.
authors.forename: Paschalis
authors.initials: P
authors.lastname: Tossios
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000517:prevention & control*; D000328:Adult; D001682:Biological Availability; D006348:Cardiac Surgical Procedures; D004187:Disaccharides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011379:Prognosis; D065608:Renal Reabsorption / Q000187:drug effects*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004187:Disaccharides; C033269:N-acetylchondrosine; D009569:Nitric Oxide
keywords: Bioavailability; Nitric oxide; Oxidative stress; Prostaglandins; Risk; Thiols