title: Why treatments do(n't) work in vitiligo: An autoinflammatory perspective.
abstract: Vitiligo is a recalcitrant depigmentary skin disorder with significant effects on the quality of life and a frequent association with other autoimmune disorders. The results of the current therapeutic options remain variable and treatment resistance is often encountered. The mainstay of treatment remains topical corticosteroids, topical calcineurin inhibitors and UVB therapy. In more extensive or progressive cases, systemic corticosteroids are effective although their prolonged use is hampered due to safety concerns. A lot of topical and systemic treatments have been investigated during the last decades. Given the elevated TNF-α levels in vitiligo lesions, the failure and even paradoxal effects of TNF-α inhibitors were highly remarkable. Nonetheless, a lot of progress has been made to unravel the pathophysiology of vitiligo. In this review, we provide an overview of the currently known underlying mechanisms leading to vitiligo and link this to the success or failure of treatments that have been used in clinical trials. We believe that this overview can direct future vitiligo research and rationalise the treatment options.
authors.affiliation: Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address: Reinhart.Speeckaert@UGent.be.
authors.forename: Reinhart
authors.initials: R
authors.lastname: Speeckaert
authors.affiliation: Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: Marijn M
authors.initials: MM
authors.lastname: Speeckaert
authors.affiliation: Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: Nanja
authors.initials: N
authors.lastname: van Geel
mesh_terms: D000287:Administration, Topical; D065095:Calcineurin Inhibitors / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D008544:Melanocytes / Q000187:drug effects; D018384:Oxidative Stress; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014467:Ultraviolet Therapy; D014820:Vitiligo / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D065095:Calcineurin Inhibitors; D005938:Glucocorticoids; D018840:HSP70 Heat-Shock Proteins; D014409:Tumor Necrosis Factor-alpha
keywords: Autoinflammatory; Pathogenesis; Treatment; Vitiligo