title: [Endoplasmic reticulum: membrane contact sites].
abstract: The review of modern data about a functional purpose of membrane contact sites (MCSs) of endoplasmic reticulum is presented. Traffic problems of lipids and calcium in MCSs are discussed. The sufficient condition for giving MCSs of certain functional is not received till now; the problem of the "anchors" providing contact of two membranes, definitively is not solved. The question of ability of MCSs to realize free diffusion of any small molecules (presumably to 1.5 kDa) and ions between compartments is discussed.
authors.forename: G A
authors.initials: GA
authors.lastname: Velikanov
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology* / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000502:physiology* / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology* / Q000648:ultrastructure; D007700:Kinetics; D050356:Lipid Metabolism; D010944:Plants
chemical_list: D002118:Calcium