title: Latent trajectory classes for alcohol-related blackouts from age 15 to 19 in ALSPAC.
abstract: BACKGROUND
  Alcohol-related blackouts (ARBs) are reported by ~50% of drinkers. While much is known about the prevalence of ARBs in young adults and their cross-sectional correlates, there are few prospective studies regarding their trajectories over time during mid-adolescence. This paper reports latent trajectory classes of ARBs between age 15 and 19, along with predictors of those patterns.
  
  
  METHODS
  Latent class growth analysis (LCGA) was used to evaluate the pattern of occurrence of ARBs across 4 time points for 1,402 drinking adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC). Multinomial regression analyses evaluated age-15 demography, substance-related items, externalizing characteristics, and estimated peer substance use as predictors of latent class membership.
  
  
  RESULTS
  ARBs were reported at age 15 in 30% and at age 19 in 74% of these subjects. Four latent trajectory classes were identified: Class 1 (5.1%) reported no blackouts; for Class 2 (29.5%), ARBs rapidly increased with age; for Class 3 (44.9%), blackouts slowly increased; and for Class 4 (20.5%), ARBs were consistently reported. Using Class 2 (rapid increasers) as the reference, predictors of class membership included female sex, higher drinking quantities, smoking, externalizing characteristics, and estimated peer substance involvement (pseudo R(2)  = 0.22).
  
  
  CONCLUSIONS
  ARBs were common and repetitive in these young subjects, and predictors of their trajectories over time involved multiple domains representing diverse characteristics.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, California.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Tom L
authors.initials: TL
authors.lastname: Smith
authors.forename: Jon
authors.initials: J
authors.lastname: Heron
authors.forename: Matthew
authors.initials: M
authors.lastname: Hickman
authors.forename: John
authors.initials: J
authors.lastname: Macleod
authors.forename: Marcus R
authors.initials: MR
authors.lastname: Munafo
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: George
authors.initials: G
authors.lastname: Davey-Smith
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000647:Amnesia / Q000139:chemically induced* / Q000453:epidemiology*; D004739:England / Q000453:epidemiology; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008960:Models, Psychological; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000431:Ethanol
keywords: Alcohol; Blackouts; Latent Trajectories; Predictors