title: Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report.
abstract: OBJECTIVE
  The aim of this study was to investigate the role of cluster of differentiation 43 (CD43), an integral membrane glycoprotein with both proadhesive and antiadhesive activities, in atherosclerosis.
  
  
  RESULTS
  Low-density lipoprotein receptor-deficient mice were lethally irradiated and reconstituted with either bone marrow from CD43(-/-) mice or from wild-type controls. We found that mice lacking the CD43 on their leukocytes had significantly less severe atherosclerosis and that, contrary to our expectation, macrophage infiltration into the vessel wall was not affected by the lack of CD43 in the leukocytes. However, we found that CD43 mediates cholesterol homeostasis in macrophages by facilitating cholesterol efflux. This resulted in a significant reduction in storage of cholesterol in the aorta of mice lacking CD43 in the leukocytes.
  
  
  CONCLUSIONS
  CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development.
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
authors.forename: Svenja
authors.initials: S
authors.lastname: Meiler
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Baumer
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
authors.forename: Sara
authors.initials: S
authors.lastname: McCurdy
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
authors.forename: Bog-Hieu
authors.initials: BH
authors.lastname: Lee
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
authors.forename: Shiro
authors.initials: S
authors.lastname: Kitamoto
authors.affiliation: From the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.). wab@hawaii.edu.
authors.forename: William A
authors.initials: WA
authors.lastname: Boisvert
mesh_terms: D000818:Animals; D001011:Aorta / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D001018:Aortic Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D050197:Atherosclerosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004195:Disease Models, Animal; D015536:Down-Regulation; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D051917:Leukosialin / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D058226:Plaque, Atherosclerotic; D011973:Receptors, LDL / Q000172:deficiency / Q000235:genetics; D013997:Time Factors
chemical_list: D051917:Leukosialin; D011973:Receptors, LDL; C497863:Spn protein, mouse; D002784:Cholesterol
keywords: atherosclerosis; macrophages