title: Contribution of influenza to acute exacerbations of chronic obstructive pulmonary disease in Kashmir, India, 2010-2012.
abstract: We estimate the contribution of influenza to hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in Kashmir, India. Prospective surveillance for influenza among patients hospitalized with AECOPD was conducted at a tertiary care hospital. Patients had clinical data collected and nasal/throat swabs tested for influenza viruses. Outcomes among patients with and without influenza were compared with logistic regression adjusting for age and underlying conditions. During October 2010-September 2012, 498 patients hospitalized with AECOPD were enrolled, of whom 40 (8%) had received influenza vaccine. Forty (8%) had influenza; influenza virus detection peaked in winter (January-March). Patients with influenza were more likely to die during hospitalization (adjusted OR 3.4, CI 1.0-11.4) than those without.
authors.affiliation: Department of Internal & Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.
authors.forename: Parvaiz A
authors.initials: PA
authors.lastname: Koul
authors.forename: Umar H
authors.initials: UH
authors.lastname: Khan
authors.forename: Romana
authors.initials: R
authors.lastname: Asad
authors.forename: Rubaya
authors.initials: R
authors.lastname: Yousuf
authors.forename: Shobha
authors.initials: S
authors.lastname: Broor
authors.forename: Renu B
authors.initials: RB
authors.lastname: Lal
authors.forename: Fatimah S
authors.initials: FS
authors.lastname: Dawood
mesh_terms: D000328:Adult; D000368:Aged; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006760:Hospitalization; D006801:Humans; D007194:India / Q000453:epidemiology; D009980:Influenza A virus / Q000302:isolation & purification; D009981:Influenza B virus / Q000302:isolation & purification; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D012621:Seasons
chemical_list: D007252:Influenza Vaccines
keywords: Chronic obstructive lung disease; chronic obstructive; hospitalization; influenza viruses; pulmonary disease