title: Protective effect of baicalein on renal ischemia/reperfusion injury in the rat.
abstract: OBJECTIVE
  To investigate the protective effect and the mechanism of baicalein (Bai) in rats with renal ischemia-reperfusion injury (RIRI).
  
  
  METHODS
  Twenty-four male Sprague-Dawley rats were divided into three groups: sham, IR, and IR+Bai. Bai was administered by tail vein injection (30 mg/kg) 30 min before reperfusion in the IR+Bai group. The IR group and sham group received saline vehicle via the intravenous route.
  
  
  RESULTS
  Rats that underwent RIRI exhibited renal functional impairment, histological changes, significantly increased advanced oxidation protein product (AOPP) and malondialdehyde (MDA) levels (p<0.01), and ICAM-1 and MCP-1 protein and mRNA expression were significantly upregulated (p<0.01). Administration of Bai reduced AOPP and MDA levels, significantly inhibited expression of inflammatory factors (p<0.05), and markedly improved renal function.
  
  
  CONCLUSIONS
  Bai promotes the recovery of renal function in established acute RIRI, and alleviates kidney injury in a rat model.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Shantou University Medical College , Shantou , China .
authors.forename: Kefei
authors.initials: K
authors.lastname: Wu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.forename: Jianwei
authors.initials: J
authors.lastname: Tian
authors.forename: Wenjing
authors.initials: W
authors.lastname: Lei
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004195:Disease Models, Animal; D044950:Flavanones / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects; D012079:Renal Circulation; D051437:Renal Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D015427:Reperfusion Injury / Q000175:diagnosis / Q000378:metabolism / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D044950:Flavanones; D018799:Intercellular Adhesion Molecule-1; C006680:baicalein; D008315:Malondialdehyde
keywords: Baicalein; inflammatory effects; ischemia–reperfusion injury; kidney injury; oxidative stress