title: [Proteolytic signaling mechanisms in skeletal muscles in patients with alcohol-induced muscle disease].
abstract: Chronic alcoholic myopathy is one of most numerous and profound manifestations of chronic alcohol intoxication. This disease is characterized by the pronounced atrophy of the locomotor muscles, which involves predominantly those fibers expressing myosin isoforms of the I "fast" type. In early experiments with alcohol-fed rats and studies of patients it was shown the impairment of the anabolic intracellular signaling pathways and decrease in protein synthesis rate. We were the first to analyze the signaling pathways involved in the pathogenesis of alcoholic myopathy with different fiber atrophy levels. At the early stages of the pathogenesis we observed also the sufficient increase of mRNA of E3 ubiquitin ligases. However the ubiquitinylation level was not altered in patients as compared to the control subjects. This phenomenon could be associated with the increased expression of the heat-shock proteins, known for their protective action.
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Lomonosova
authors.forename: E A
authors.initials: EA
authors.lastname: Lysenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kazantseva
authors.forename: O E
authors.initials: OE
authors.lastname: Zinov'eva
authors.forename: N N
authors.initials: NN
authors.lastname: Iakhno
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005260:Female; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D009218:Myosins / Q000096:biosynthesis; D059748:Proteolysis; D051381:Rats; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis
chemical_list: D006360:Heat-Shock Proteins; D044767:Ubiquitin-Protein Ligases; D009218:Myosins