title: Curcumolide, a unique sesquiterpenoid with anti-inflammatory properties from Curcuma wenyujin.
abstract: Curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from Curcuma wenyujin. The structure and absolute configuration were elucidated by extensive NMR, ECD data analysis, and a single-crystal X-ray study. This molecule exhibited significant anti-inflammatory effects in LPS-induced RAW 264.7 macrophages. It suppressed LPS-induced NF-κB activation, including the nuclear translocation and DNA binding activity of NF-κB, and decreased tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), nitric oxide (NO) and reactive oxygen species (ROS) production. Therefore, Curcumolide may have therapeutic potential for treating inflammatory diseases by inhibiting NF-κB activation and pro-inflammatory mediator production.
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China. Electronic address: jianyd@wmu.edu.cn.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shao
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
authors.affiliation: Wenzhou University, Wenzhou 325035, People's Republic of China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cai
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
authors.forename: Lianglian
authors.initials: L
authors.lastname: Fang
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People's Republic of China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D018360:Crystallography, X-Ray; D030024:Curcuma; D003474:Curcumin / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D027343:Rhizome; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D018836:Inflammation Mediators; D012717:Sesquiterpenes; D003474:Curcumin
keywords: Anti-inflammatory effects; Curcuma wenyujin; Curcumolide; Sesquiterpenoid