title: Effects of oxygen in lungs of rats.
abstract: OBJECTIVE
  To analyze microscopically the effects of different concentrations of oxygen in the lungs of rats.
  
  
  METHODS
  There were 20 rats distributed in three experimental groups (concentration of oxygen to 40%, 70% and 100%) and a control group. The animals were exposed to the oxygen in a chamber of acrylic during three days and after exposition, the animals were submitted to median thoracotomia to remove the lungs. The lung tissue of all of the animals was analyzed as regards presence of acute and chronic inflammation, capillary congestion, alveolar walls thick, interstitial and alveolar edema, alveolar hemorrhage, denudation capillary and alveolar endothelium areas and atelectasis.
  
  
  RESULTS
  The analysis histopathologic revealed significant statistics difference for acute and chronic inflammation, capillary congestion, alveolar walls thick, interstitial and alveolar edema, alveolar hemorrhage, denudation capillary and alveolar epithelium areas.
  
  
  CONCLUSIONS
  Exposition to the oxygen during 72 hours in the concentration of 40% does not produce significant histopathologic alterations in the lung tissue; in the concentration of 70%, can promotes the alveolar walls thick and capillary congestion and in the concentration of 100% can cause death and originate diffuse pulmonary lesion.
authors.affiliation: Department of Physiotherapy, Faculty Santa Terezinha, Sao Luis, MA, Brazil.
authors.forename: Alexandre Luiz Albuquerque
authors.initials: AL
authors.lastname: Pereira
authors.affiliation: CEST, Sao Luis, MA, Brazil.
authors.forename: Márcia Raissa Aragão
authors.initials: MR
authors.lastname: Ferreira
authors.affiliation: Department of Medicine II, Federal University of Maranhao, Sao Luis, MA, Brazil.
authors.forename: Orlando José dos
authors.initials: OJ
authors.lastname: Santos
authors.affiliation: Presidente Dutra University Hospital, UFMA, Sao Luis, MA, Brazil.
authors.forename: Euler Nicolau
authors.initials: EN
authors.lastname: Sauaia Filho
authors.affiliation: Federal Institute of Education, Science and Technology of Maranhao, Sao Luis, MA, Brazil.
authors.forename: Antônio Ernandes Macedo
authors.initials: AE
authors.lastname: Paiva
authors.affiliation: Federal University of Paraiba, Joao Pessoa, PB, Brazil.
authors.forename: Rayan Haquim Pinheiro
authors.initials: RH
authors.lastname: Santos
authors.affiliation: UFMA, Sao Luis, MA, Brazil.
authors.forename: Rennan Abud Pinheiro
authors.initials: RA
authors.lastname: Santos
mesh_terms: D000818:Animals; D005260:Female; D006940:Hyperemia / Q000139:chemically induced; D008168:Lung / Q000473:pathology*; D023421:Models, Animal; D010100:Oxygen / Q000009:adverse effects* / Q000633:toxicity; D011014:Pneumonia / Q000139:chemically induced; D011650:Pulmonary Alveoli / Q000293:injuries / Q000473:pathology*; D001261:Pulmonary Atelectasis / Q000139:chemically induced; D011897:Random Allocation; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010100:Oxygen