title: mRNP granules. Assembly, function, and connections with disease.
abstract: Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that harbor non-translating mRNAs bound by various proteins that regulate mRNA translation, localization, and turnover. Their importance in gene expression regulation is far reaching, ranging from precise spatial-temporal control of mRNAs that drive developmental programs in oocytes and embryos, to similarly exquisite control of mRNAs in neurons that underpin synaptic plasticity, and thus, memory formation. Analysis of mRNP granules in their various contexts has revealed common themes of assembly, disassembly, and modes of mRNA regulation, yet new studies continue to reveal unexpected and important findings, such as links between aberrant mRNP granule assembly and neurodegenerative disease. Continued study of these enigmatic structures thus promises fascinating new insights into cellular function, and may also suggest novel therapeutic strategies in various disease states.
authors.affiliation: a Department of Molecular and Cellular Biology ; University of Arizona ; Tucson , AZ USA.
authors.forename: J Ross
authors.initials: JR
authors.lastname: Buchan
mesh_terms: D003594:Cytoplasmic Granules / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000473:pathology; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D014176:Protein Biosynthesis / Q000235:genetics; D034443:RNA Transport / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics* / Q000378:metabolism; D013569:Synapses / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein
keywords: 4E-BP, eIF4E binding protein; ALS, amyotropic lateral sclerosis; FRAP, fluorescence recovery after photobleaching; FTLD, frontotemporal lobar degeneration; HSP, heat shock protein; IMC, inter-mitochondrial cement; MSP, multi-system proteinopathy; P-bodies; RISC, RNA induced silencing complex; decay; germ granules; mRNA; mRNP, messenger ribonucleoprotein; neurodegenerative disease; neuronal transport granules; repression; stress granules; translation