title: [Pro-angiogenic cytokines in systemic sclerosis].
abstract: Systemic sclerosis (SSc) is a multifactorial connective tissue disease characterized by excessive and progressive fibrosis along with microvasculopathy due to poor vascular formation and repair. Despite a general increase in many potent angiogenic factors, the vasculopathy compensatory angiogenesis and vasculogenesis are impaired. In this review, we discuss the role of proangiogenic factors--VEGF, PlGF, endoglin, PDGF, endothelin-1, angiopoietins, SDF-1, uPAR--and the paradoxical paucity of an inadequate angiogenic response in SSc.
authors.affiliation: Klinika Dermatologii i Wenerologii Uniwersytet Medyczny w Łodzi.
authors.forename: Ewa
authors.initials: E
authors.lastname: Robak
authors.affiliation: Klinika Dermatologii i Wenerologii Uniwersytet Medyczny w Łodzi.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Gerlicz
mesh_terms: D042682:Angiopoietins / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D019332:Endothelin-1 / Q000378:metabolism*; D006801:Humans; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D042682:Angiopoietins; D054377:Chemokine CXCL12; D016207:Cytokines; D019332:Endothelin-1; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor