title: Syntheses, structures, and antimicrobial activity of new remarkably light-stable and water-soluble tris(pyrazolyl)methanesulfonate silver(I) derivatives of N-methyl-1,3,5-triaza-7-phosphaadamantane salt - [mPTA]BF4.
abstract: Two new silver(I) complexes of formula [Ag(mPTA)4](Tpms)4(BF4) (1) and [Ag(Tpms)(mPTA)](BF4) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1-yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, (1)H and (31)P{(1)H} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)](5+), 1 being the first reported coordination compound bearing a κ(0)-Tpms. 1 features high solubility and stability in water (S25 °C ≈ 30 mg·mL(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans.
authors.affiliation: Faculty of Chemistry, University of Wrocław , ul. F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Smoleński
authors.forename: Claudio
authors.initials: C
authors.lastname: Pettinari
authors.forename: Fabio
authors.initials: F
authors.lastname: Marchetti
authors.forename: M Fátima C
authors.initials: MF
authors.lastname: Guedes da Silva
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Gretta Veronica
authors.initials: GV
authors.lastname: Badillo Patzmay
authors.forename: Dezemona
authors.initials: D
authors.lastname: Petrelli
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vitali
authors.forename: Armando J L
authors.initials: AJ
authors.lastname: Pombeiro
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D058892:Adenosine Deaminase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002417:Cattle; D060326:Chemistry Techniques, Synthetic; D004355:Drug Stability; D008027:Light; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012834:Silver / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: C501763:1,3,5-triaza-7-phosphaadamantane; D058892:Adenosine Deaminase Inhibitors; D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D014867:Water; D012710:Serum Albumin, Bovine; D012834:Silver; D000218:Adamantane