title: Fatal sulfasalazine-induced eosinophilic myocarditis in a patient with periodic fever syndrome.
abstract: OBJECTIVE
  The aim of this paper is to report the first case of drug-induced eosinophilic myocarditis (EM) in a patient with hereditary periodic fever syndrome (PFS).
  
  
  METHODS
  A 28-year-old man with hyper-IgD syndrome, one of the PFS, developed a sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arthritis, the patient developed fever, facial/neck edema, rash and cardiogenic shock, and died within 8 h. The autopsy revealed hemophagocytosis, while acute heart failure caused by necrotizing EM was established as the cause of death.
  
  
  CONCLUSIONS
  This was a case of drug-induced EM in a patient with PFS that had an atypical presentation, rapid evolution and poor outcome.
authors.affiliation: Institute of Rheumatology, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivica
authors.initials: I
authors.lastname: Jeremic
authors.forename: Nada
authors.initials: N
authors.lastname: Vujasinovic-Stupar
authors.forename: Tatjana
authors.initials: T
authors.lastname: Terzic
authors.forename: Nemanja
authors.initials: N
authors.lastname: Damjanov
authors.forename: Milos
authors.initials: M
authors.lastname: Nikolic
authors.forename: Branka
authors.initials: B
authors.lastname: Bonaci-Nikolic
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy; D001344:Autopsy; D004802:Eosinophilia / Q000139:chemically induced; D017809:Fatal Outcome; D005334:Fever / Q000150:complications; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D012770:Shock, Cardiogenic / Q000150:complications; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine