title: Isoquinoline synthesis by heterocyclization of tosylmethyl isocyanide derivatives: total synthesis of mansouramycin B.
abstract: A new method for the synthesis of isoquinolines through a catalytic acid-mediated cyclization of α-benzyl TosMIC derivatives has been developed. This methodology has been successfully applied to the total synthesis of mansouramycin B. This is the first total synthesis of this compound to be reported in the literature.
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Coppola
authors.forename: David
authors.initials: D
authors.lastname: Sucunza
authors.forename: Carolina
authors.initials: C
authors.lastname: Burgos
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Vaquero
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D003486:Cyanides; D007546:Isoquinolines; C000595751:mansouramycin B; C469613:tosylmethyl isocyanide