title: α-Amylase inhibitory activity of some traditionally used medicinal species of Labiatae.
abstract: BACKGROUND
  Natural α-amylase inhibitors of herbal origin are an attractive therapeutic approach to control post-prandial hyperglycemia via reducing the glucose release from starch and delaying carbohydrate absorption. These compounds are able to inhibit the activity of the carbohydrate hydrolyzing enzymes in the small intestine and potentially useful in control of diabetes. The enlarged Lamiaceae (Labiatae) family contains about 6,900 to 7,200 species worldwide and many species of this family possess medicinal properties and have been used traditionally for treatment of chronic illnesses including diabetes.
  
  
  METHODS
  In the present study particular species of Labiatae family from the genera, Phlomis, Satureja, Salvia, Scutellarua, Stachys and Hymenocrater, which are growing wildly in Iran, selected to evaluate for possible in vitro α-amylase inhibitory activity, compared to acarbose as a positive control.
  
  
  RESULTS
  The inhibitory activities of all the herbal extracts were varied from 1.9 to 18.6 (IC50, μg/mL). Additionally, the ethyl acetate extract of P. bruguieri (IC50 = 1.9 μg/mL) and the butanol extract of P. persica (IC50 = 3.6 μg/mL) exhibited the lowest IC50 values among all the species as the most potent herbal extracts, while the inhibitory activity of S. sahendica and S. macrosiphon (ethyl acetate extracts) as well as P. caucasica (butanol extract) on α-amylase enzyme was observed as weak and did not reach at least to the 50% of the enzyme inhibition level.
  
  
  CONCLUSIONS
  Taking together, P. bruguieri and P. persica among the Phlomis species can be the promising sources of α-amylase inhibitors. However, P. rigida, S. bizantina and H. bituminosus that exhibited moderate activity can be stand on second level of interest.
authors.affiliation: Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran.
authors.forename: Hedieh
authors.initials: H
authors.lastname: Safamansouri
authors.affiliation: Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Nikan
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Amin
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Sarkhail
authors.affiliation: Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran ; Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Gohari
authors.affiliation: Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Kurepaz-Mahmoodabadi
authors.affiliation: Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran ; Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Saeidnia
keywords: Hymenocrater; Phlomis; Salvia; Satureja; Scutellarua; Stachys; α-amylase inhibitory