title: Multiple venous aneurysms in a patient with hypereosinophilic syndrome.
abstract: Hypereosinophilic syndrome (HES) is a diverse group of rare disorders, defined by persistent peripheral blood eosinophilia (>1500 per mm(3)), the absence of a primary cause of eosinophilia (such as parasitic or allergic disease), and evidence of eosinophil-mediated end-organ damage. Arterial aneurysms have been previously reported in these patients. This is the first report of a patient with HES and multiple venous aneurysms, causing recurrent pulmonary thromboembolism. Venous aneurysms can represent eosinophil-mediated, potentially fatal end-organ damage in patients with HES.
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
authors.forename: W S J
authors.initials: WS
authors.lastname: Malskat
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Racz
authors.affiliation: Department of Vascular Surgery, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: ten Raa
authors.affiliation: Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Lugtenburg
authors.affiliation: Department of Pathology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
authors.forename: V Noordhoek
authors.initials: VN
authors.lastname: Hegt
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands m.demaeseneer@erasmusmc.nl.
authors.forename: M G R
authors.initials: MG
authors.lastname: de Maeseneer
mesh_terms: D000783:Aneurysm; D017809:Fatal Outcome; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
keywords: Hypereosinophilic syndrome; chronic venous insufficiency; venous aneurysms