title: [Changes in gene expression and content of titin (connectin) in striated muscles of chronically etihanol-fed rats].
abstract: Changes in gene expression and isoform composition of giant sarcomeric protein titin (connectin) in cardiac muscle, as well as changes of its isoform composition in skeletal muscle (m. soleus) of chronically ethanol-fed rats have been studied using real-time RT-PCR and low percentage SDS-gel electrophoresis. The decrease of titin content in examined muscles and the decrease in titin gene expression in myocardium of chronically ethanol-fed rats have been shown. These changes indicate the development of pathologic process.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gritsyna
authors.forename: N N
authors.initials: NN
authors.lastname: Salmov
authors.forename: I M
authors.initials: IM
authors.lastname: Vikhliantsev
authors.forename: A D
authors.initials: AD
authors.lastname: Ulanova
authors.forename: M G
authors.initials: MG
authors.lastname: Sharapov
authors.forename: V V
authors.initials: VV
authors.lastname: Teplova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Podlubnaia
mesh_terms: D000437:Alcoholism / Q000235:genetics* / Q000473:pathology; D000818:Animals; D064211:Connectin / Q000096:biosynthesis* / Q000235:genetics; D000431:Ethanol / Q000633:toxicity; D005786:Gene Expression Regulation / Q000187:drug effects*; D054792:Muscle, Striated / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D020033:Protein Isoforms / Q000096:biosynthesis; D051381:Rats
chemical_list: D064211:Connectin; D020033:Protein Isoforms; D000431:Ethanol