title: [Influence of melatonin and diclofenac on circadian rhythm of locomotor activity in rats with local inflammatory arthritis].
abstract: Inflammatory arthritis is accompanied by disorganization of the circadian rhythm of locomotion in rats. Control saline injections increased the rhythm disturbances. Chronic administration of melatonin (5 mg/kg) attenuated these chronopathological shifts. Diclofenac demonstrated much lower positive chronopharmacological activity than did melatonin.
authors.forename: A V
authors.initials: AV
authors.lastname: Popov
authors.forename: S S
authors.initials: SS
authors.lastname: Naumov
authors.forename: É B
authors.initials: ÉB
authors.lastname: Arushanian
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004008:Diclofenac / Q000494:pharmacology*; D005557:Formaldehyde; D007274:Injections, Intraperitoneal; D008027:Light; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D004008:Diclofenac; D005557:Formaldehyde; D012965:Sodium Chloride; D008550:Melatonin