title: Catalytic C-H allylation and benzylation of pyrazoles.
abstract: We describe a general approach for the synthesis of allylated and benzylated pyrazoles. An electron-withdrawing substituent, such as nitro, chloro, and ester groups, at C4 renders the Lewis basic nitrogen atom to be less basic and the C-H bond more acidic than the ones of the parent ring, enabling Pd-catalyzed C-H allylation and benzylation reactions of pyrazoles. The new method expanding the scope of the C-H functionalization of pyrazoles beyond arylation reactions provides a rapid access to complex pyrazole compounds.
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Seri
authors.initials: S
authors.lastname: Bae
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Ha-Lim
authors.initials: HL
authors.lastname: Jang
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Haeun
authors.initials: H
authors.lastname: Jung
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Joo
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D001593:Benzyl Compounds; D011720:Pyrazoles; D010165:Palladium