title: Effect of intracoronary tirofiban on platelet alpha-granule membrane protein and myocardial perfusion level during emergency percutaneous coronary intervention.
abstract: This study aimed to investigate the effect of intracoronary application of tirofiban on platelet alpha-granule membrane protein (GMP-140) and myocardial perfusion levels during emergency percutaneous coronary intervention (PCI). A total of 70 patients who accepted emergency PCI treatment were randomly divided into tirofiban and control groups. We determined GMP-140 and troponin I (cTnI) levels before and 12 h after surgery, as well as N-terminal pro-brain natriuretic peptide levels 1 and 7 days after surgery in the two groups. The results showed that GMP-140 and cTnI levels were significantly (P < 0.01) lower in the tirofiban group than in the control group 12 h after operation (17.99 ± 1.01 vs 24.56 ± 1.96 μg/L and 50.96 ± 2.20 vs 58.69 ± 2.34 ng/mL, respectively). The D-value of the N-terminal pro-brain natriuretic peptide levels between 1 and 7 days after operation was significantly higher in the tirofiban group than in the control group (894.19 ± 90.91 vs 829.50 ± 84.18 pg/mL; P < 0.01). The intracoronary application of tirofiban during emergency PCI clearly reduced the GMP-140 level, inhibited the activation function of platelets, improved myocardial perfusion, and helped recover cardiac function in patients.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical College, Binzhou, Shangdong, China.
authors.forename: H P
authors.initials: HP
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China changmeiliu@yeah.net.
authors.forename: C M
authors.initials: CM
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical College, Binzhou, Shangdong, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Zhang
mesh_terms: D000368:Aged; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D019007:P-Selectin / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D062645:Percutaneous Coronary Intervention; D010477:Perfusion; D000077466:Tirofiban; D019210:Troponin I / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D019007:P-Selectin; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014443:Tyrosine; D000077466:Tirofiban