title: Aneurysmal bone cyst does not hinder the success of kidney transplantation. A case report.
abstract: Uremic osteodystrophy is an expected complication in subjects with chronic renal insufficiency. It develops gradually and progressively already during the conservative treatment and then during the dialysis treatment. It can present a wide histopathological spectrum including typical alterations (from osteitis fibrosa to osteomalacia and/or mixed lesions) or, more rarely, isolated bone lesions indicative of a brown tumor of the bone. These conditions must be clearly identified in the pretransplant phase, especially if a bone lesion indicative of a pathological condition possibly evolving into a neoplasm is detected fortuitously. We report the case of a 19-yr-old boy with renal insufficiency and candidate for a pre-emptive renal transplantation from a living donor, in whom the diagnosis of ABC of the pubic symphysis - asymptomatic and fortuitously detected while performing instrumental investigations - was suspected through the imaging studies (CT scan, MRI) and was confirmed by the histological examination. This made it possible to perform the renal transplant. The immunosuppressive treatment, which was subsequently administered, was based on steroids, calcineurin inhibitors (tacrolimus), and mycophenolate and did not determine any modification in the radiological aspect of the bone lesion, even after more than one yr from the transplant.
authors.affiliation: Pediatric Nephrology and Dialysis Unit, Children's Hospital Giovanni XXIII, Bari, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Giordano
authors.forename: Giorgia
authors.initials: G
authors.lastname: Caloro
authors.forename: Alberto
authors.initials: A
authors.lastname: Gaeta
authors.forename: Antonio
authors.initials: A
authors.lastname: Vergori
authors.forename: Luisa
authors.initials: L
authors.lastname: Santangelo
authors.forename: Paolo
authors.initials: P
authors.lastname: Giordano
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D000783:Aneurysm / Q000150:complications*; D001845:Bone Cysts / Q000150:complications*; D001842:Bone and Bones / Q000473:pathology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008297:Male; D051437:Renal Insufficiency / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014511:Uremia / Q000150:complications*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: immunosuppressive treatment; kidney transplant; uremic osteodystrophy