title: The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach.
abstract: The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 ± 2.0 mm and 4.0 ± 1.0 mm, resp.; P < 0.001). The level of TOS was higher in the MeS group compared to the control group (P < 0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P < 0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P < 0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Demir
authors.affiliation: Department of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Demir
authors.affiliation: Department of Cardiology, İstinye State Hospital, Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Acıksarı
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Uygun
authors.affiliation: Department of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey.
authors.forename: Irem Kırac
authors.initials: IK
authors.lastname: Utku
authors.affiliation: Department of Biochemistry, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbasi
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Ilker Murat
authors.initials: IM
authors.lastname: Caglar
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Pirhan
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Hande Oktay
authors.initials: HO
authors.lastname: Tureli
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Ersan
authors.initials: E
authors.lastname: Oflar
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Ungan
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ciftci
authors.affiliation: Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Karakaya