title: Modeling human lung development and disease using pluripotent stem cells.
abstract: Directed differentiation of human pluripotent stem cells (hPSCs) into mature cells, tissues and organs holds major promise for the development of novel approaches in regenerative medicine, and provides a unique tool for disease modeling and drug discovery. Sometimes underappreciated is the fact that directed differentiation of hPSCs also provides a unique model for human development, with a number of important advantages over model organisms. Here, I discuss the importance of using human stem cell models for understanding human lung development and disease.
authors.affiliation: Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA Department of Medicine, Columbia University Medical Center, New York, NY, USA Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA hs2680@columbia.edu.
authors.forename: Hans-Willem
authors.initials: HW
authors.lastname: Snoeck
mesh_terms: D006801:Humans; D008168:Lung / Q000196:embryology* / Q000473:pathology*; D008171:Lung Diseases / Q000196:embryology*; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000473:pathology*