title: Time trends in pulmonary embolism mortality in France, 2000-2010.
abstract: BACKGROUND
  Pulmonary Embolism (PE) is a potentially fatal complication of venous thrombosis. Recent and comprehensive estimates of PE incidence and mortality are scarce. Moreover, while contemporary mortality trends of PE would enable the evaluation of prevention and quality of care, such data are lacking. The aim of this study was to provide nationwide estimations of PE mortality and time trends in France between 2000 and 2010.
  
  
  METHODS
  Mortality data were obtained from the French Epidemiology Center on medical causes of death. Mortality rates were calculated with PE as an underlying or one of multiple causes of death. The annual percentage changes were assessed using a Poisson regression model. Age-standardized PE mortality rates were also assessed.
  
  
  RESULTS
  In 2010, the overall age-adjusted PE mortality rate was 21.0 per 100000. This rate was 30% higher in men than in women and decreased by 3% per year between 2000 and 2010. Over this period, PE mortality declined in men and women over 55 years but only slightly decreased in patients younger than 55. Cancer, obesity, osteopathies and complications of surgery were often coded as the underlying causes of death when PE was an associated cause of death recorded on certificate.
  
  
  CONCLUSIONS
  This study is the first to provide a contemporary and exhaustive nationwide estimation of PE mortality and time trends in France. The observed decrease in PE mortality between 2000 and 2010 is encouraging, but further efforts in prevention are needed to ensure that this reduction is widespread in all age groups.
authors.affiliation: Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France. Electronic address: v.olie@invs.sante.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Olié
authors.affiliation: Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Fuhrman
authors.affiliation: Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Chin
authors.affiliation: National Institute of Health and Medical Research (Inserm), French Epidemiology Center on medical causes of death (CépiDc), Le Kremlin-Bicêtre, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Lamarche-Vadel
authors.affiliation: National Institute of Health and Medical Research (Inserm), Hormones and Cardiovascular Disease, Center for Research in Epidemiology and Population Health, Villejuif, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Scarabin
authors.affiliation: Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France.
authors.forename: Christine
authors.initials: C
authors.lastname: de Peretti
mesh_terms: D002423:Cause of Death; D005260:Female; D005602:France; D049674:History, 21st Century; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000401:mortality*; D013997:Time Factors
keywords: Cause of death; Epidemiology; France; Mortality; Pulmonary Embolism