title: Epigenetics and lupus.
abstract: Systemic lupus erythematosus (SLE) is among the systemic autoimmune diseases whose complex pathogenesis involves both genetic and environmental factors. Epigenetic dysregulation resulting in overexpression of certain genes in some of the key immune cells, such as T cells, has been incriminated in the pathophysiology of SLE. Epigenetics is defined as transmissible and reversible modifications in gene expression without alterations in the nucleotide sequences. Epigenetic information is carried chiefly by DNA itself, histones, and noncoding RNAs. Several epigenetic mechanisms may play a role in SLE pathogenesis. This review discusses the various epigenetic mechanisms that regulate gene expression and provides examples relevant to SLE.
authors.affiliation: Université Paris-Sud, hôpitaux universitaires Paris-Sud, AP-HP, 94275 Le Kremlin-Bicêtre, France; Institut National de la santé et de la recherche médicale (Inserm) U1012, 94275 Le Kremlin-Bicêtre, France. Electronic address: corinne.miceli@bct.aphp.fr.
authors.forename: Corinne
authors.initials: C
authors.lastname: Miceli-Richard
mesh_terms: D004247:DNA / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000502:physiology*; D057890:Epigenomics; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D022661:RNA, Untranslated / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D006657:Histones; D022661:RNA, Untranslated; D004247:DNA
keywords: Epigenetics; Histones; Methylation; Noncoding RNAs; Systemic lupus erythematosus