title: [Lipid metabolism and castration resistant prostate cancer].
abstract: Epidemiological studies showed the inverse association between statin use and prostate cancer incidence, especially advanced stages, or mortality. Recent report on association of postdiagnostic use of statin with reduction of prostatic or all-cause mortality strengthened the evidence in this subject. Our basic research findings demonstrated multiple mechanisms of lipid on prostate cancer proliferations. We also showed the mechanism of statin action on prostate cancer cells via IGF1-receptor or LDL receptor cascades. These findings will serve the new strategy for progressive and castration resistant prostate cancer management.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sekine
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
mesh_terms: D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D050356:Lipid Metabolism; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D011944:Receptors, Androgen / Q000378:metabolism; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011944:Receptors, Androgen