title: Glucagonoma-induced acute heart failure.
abstract: Neuroendocrine tumours (NETs) represent a broad spectrum of tumours, of which the serotonin-producing carcinoid is the most common and has been shown to cause right ventricular heart failure. However, an association between heart failure and NETs other than carcinoid has not been established so far. In this case report, we describe a 51-year-old patient with a glucagon-producing NET of the pancreas who developed acute heart failure and even cardiogenic shock despite therapy. Heart failure eventually regressed after initialising i.v. treatment with the somatostatin analogue octreotide. Chromogranin A as a tumour marker was shown to be significantly elevated, and it decreased with clinical improvement of the patient. The effects of long-time stimulation of glucagon on the myocardium have not been studied yet; however, sarcoplasmic reticulum calcium leak can be discussed as a possible mechanism for glucagon-induced heart failure.
  
  
  CONCLUSIONS
  Glucagonoma can be a cause for heart failure.i.v. infusion of octreotide can be successfully used to treat glucagonoma-induced acute heart failure.We suggest that cardiac function should be monitored in all NET patients.
authors.affiliation: Department of Cardiology and Angiology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Lukas J
authors.initials: LJ
authors.lastname: Lehner
authors.affiliation: Department of Cardiology and Angiology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Damaris
authors.initials: D
authors.lastname: Praeger
authors.affiliation: Department of Cardiology and Angiology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Gert
authors.initials: G
authors.lastname: Baumann
authors.affiliation: Department of Cardiology and Angiology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Knebel
authors.affiliation: Department of Endocrinology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Quinkler
authors.affiliation: Department of Cardiology and Angiology, Charité - Universitätsmedizin Berlin , Charitéplatz 1, 10115, Berlin , Germany.
authors.forename: Torsten K
authors.initials: TK
authors.lastname: Roepke