title: Cardiac adipose tissue and its relationship to diabetes mellitus and cardiovascular disease.
abstract: Type-2 diabetes mellitus (T2DM) plays a central role in the development of cardiovascular disease (CVD). However, its relationship to epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) in particular is important in the pathophysiology of coronary artery disease. Owing to its close proximity to the heart and coronary vasculature, EAT exerts a direct metabolic impact by secreting proinflammatory adipokines and free fatty acids, which promote CVD locally. In this review, we have discussed the relationship between T2DM and cardiac fat deposits, particularly EAT and PAT, which together exert a big impact on the cardiovascular health.
authors.affiliation: Adam M Noyes, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, United States.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Noyes
authors.affiliation: Adam M Noyes, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, United States.
authors.forename: Kirandeep
authors.initials: K
authors.lastname: Dua
authors.affiliation: Adam M Noyes, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, United States.
authors.forename: Ramprakash
authors.initials: R
authors.lastname: Devadoss
authors.affiliation: Adam M Noyes, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, United States.
authors.forename: Lovely
authors.initials: L
authors.lastname: Chhabra
keywords: Cardiovascular disease; Epicardial adipose tissue; Pericardial adipose tissue; Type 2 diabetes