title: The fungal microbiota of de-novo paediatric inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients.
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Mukhopadhya
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom; Department of Paediatric Gastroenterology, The Royal Hospital for Sick Children, Glasgow G3 8SJ, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Hansen
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast BT9 5BN, Northern Ireland, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Meharg
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
authors.forename: J M
authors.initials: JM
authors.lastname: Thomson
authors.affiliation: Department of Paediatric Gastroenterology, The Royal Hospital for Sick Children, Glasgow G3 8SJ, United Kingdom.
authors.forename: R K
authors.initials: RK
authors.lastname: Russell
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Berry
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
authors.forename: E M
authors.initials: EM
authors.lastname: El-Omar
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom. Electronic address: g.l.hold@abdn.ac.uk.
authors.forename: G L
authors.initials: GL
authors.lastname: Hold
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D005658:Fungi / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000382:microbiology*; D064307:Microbiota / Q000235:genetics*
keywords: Fungal microbiota; Gut microbiota; Paediatric inflammatory bowel disease