title: [Gastroesophageal reflux disease and connective tissue dysplasia in aspect of premorbid and comorbid disorders].
abstract: OBJECTIVE
  To investigate the phenotypic and visceral signs of connective tissue dysplasia (CTD) and comorbid diseases of the digestive system in gastroesophageal reflux disease (GERD) patients with different types of esophageal reflux as the predictors of its variants.
  
  
  METHODS
  In 124 patients with GERD the clinical features, phenotypic and visceral signs of undifferentiated CTD were studied in details.
  
  
  RESULTS
  In 82.0% of patients with GERD associated with gastroesophageal type of reflux (GER) phenotypic and especially visceral signs of STD were detected, mainly in the form of cardiochalasia and hiatal hernia. In patients with duodenogastroesophageal reflux symptoms (DGER) the signs of STD were marked in 42.0% of cases, mostly in the form of biliary tract structure abnormalities. The risk of GERD associated with prevalence of GER, was 11.9 times higher in the presence of diagnostically meaningful combination of 6 or more signs of STD than in patients with DGER. Realization of predictor options in GER occurs in the preference of sharp, acidic foods, spices, taking medications that reduce lower esophageal sphincter tone. GERD, associated with DGER, is formed in patients with family history of diseases of the biliary tract and in the preference of food rich of calories.
  
  
  CONCLUSIONS
  Study of STD symptoms as predictors of structural development of GERD and its variants is prospective to predict disease, choice of profession and eating behavior, primarily in young adults.
authors.forename: G S
authors.initials: GS
authors.lastname: Dzhulaĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Sekareva
authors.forename: T E
authors.initials: TE
authors.lastname: Dzhulaĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D001659:Biliary Tract / Q000473:pathology / Q000503:physiopathology; D003238:Connective Tissue / Q000473:pathology / Q000503:physiopathology; D004383:Duodenogastric Reflux / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D049630:Esophageal Sphincter, Lower / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006551:Hernia, Hiatal / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged