title: Imaging of gliomas at 1.5 and 3 Tesla - A comparative study.
abstract: BACKGROUND
  Glioma follow-up is based on MRI parameters, which are correlated with survival. Although established criteria are used to evaluate tumor response, radiological markers may be confounded by differences in instrumentation including the magnetic field strength. We assessed whether MRIs obtained at 3 Tesla (T) and 1.5T provided similar information.
  
  
  METHODS
  We retrospectively compared imaging features of 30 consecutive patients with WHO grades II and III gliomas who underwent MRI at 1.5T and 3T within a month of each other, without any clinical changes during the same period. We compared lesion volumes on fluid attenuation inversion recovery (FLAIR), ratio of cerebral blood volume (rCBV) on perfusion-weighted imaging, contrast-to-noise ratio (CNR) on FLAIR, and on post-gadolinium 3D T1-weighted sequences between 1.5T and 3T using intraclass correlation coefficient (ICC). Concordance between observers within and between modalities was evaluated using weighted-kappa coefficient (wκ).
  
  
  RESULTS
  The mean ± SD delay between modalities (1.5T and 3T MRI) was 8.6 ± 5.6 days. Interobserver/intraobserver concordance for lesion volume was almost perfect for 1.5T (ICC = 0.96/0.97) and 3T (ICC = 0.99/0.98). Agreement between observers for contrast enhancement was excellent at 1.5T (wκ = 0.92) and 3T (wκ = 0.92). The tumor CNR was significantly higher for FLAIR at 1.5T (P < .001), but it was higher at 3T (P = .012) for contrast enhancement. Correlations between modalities for lesion volume (ICC = 0.97) and for rCBV values (ICC = 0.92) were almost perfect.
  
  
  CONCLUSIONS
  In the follow-up of WHO grades II and III gliomas, 1.5T and 3T provide similar MRI features, suggesting that monitoring could be performed on either a 1.5 or a 3T MR magnet.
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Lambros
authors.initials: L
authors.lastname: Tselikas
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Souillard-Scemama
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Olivier
authors.initials: O
authors.lastname: Naggara
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Charles
authors.initials: C
authors.lastname: Mellerio
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Pascale
authors.initials: P
authors.lastname: Varlet
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Edouard
authors.initials: E
authors.lastname: Dezamis
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Julien
authors.initials: J
authors.lastname: Domont
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dhermain
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Bertrand
authors.initials: B
authors.lastname: Devaux
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chrétien
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Meder
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Johan
authors.initials: J
authors.lastname: Pallud
authors.affiliation: Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).
authors.forename: Catherine
authors.initials: C
authors.lastname: Oppenheim
mesh_terms: D003287:Contrast Media; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005682:Gadolinium; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D015173:Supratentorial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: MRI; glioma; neuroimaging; observer variation; reproducibility of results