title: Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease.
abstract: Vascular abnormalities are a key feature of Alzheimer's disease (AD). Imaging of cerebral vascular reactivity (CVR) is a powerful tool to investigate vascular health in clinical populations although the cause of reduced CVR in AD patients is not fully understood. We investigated the specific role of tau pathology in CVR derangement in AD using the rTg4510 mouse model. We observed an increase in CVR in cortical regions with tau pathology. These data suggest that tau pathology alone does not produce the clinically observed decreases in CVR and implicates amyloid pathology as the dominant etiology of impaired CVR in AD patients.
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Wells
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Holly E
authors.initials: HE
authors.lastname: Holmes
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: James M
authors.initials: JM
authors.lastname: O'Callaghan
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Niall
authors.initials: N
authors.lastname: Colgan
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Ozama
authors.initials: O
authors.lastname: Ismail
authors.affiliation: Department of Neurodegenerative Disease, Institute of Neurology, UCL, London, UK.
authors.forename: Elizabeth Mc
authors.initials: EM
authors.lastname: Fisher
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Bernard
authors.initials: B
authors.lastname: Siow
authors.affiliation: Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK.
authors.forename: Tracey K
authors.initials: TK
authors.lastname: Murray
authors.affiliation: Tailored Therapeutics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Schwarz
authors.affiliation: Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: O'Neill
authors.affiliation: Tailored Therapeutics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Collins
authors.affiliation: UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lythgoe
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging; D051379:Mice; D008822:Mice, Transgenic; D013113:Spin Labels; D016875:tau Proteins / Q000378:metabolism*
chemical_list: C558298:Mapt protein, mouse; D013113:Spin Labels; D016875:tau Proteins