title: Imaging of the peritoneum evaluated by 99mTc-icodextrin scintigraphy in peritoneal dialysis patients: preliminary data.
abstract: OBJECTIVE
  In this study, we proposed a peritoneal scintigraphy with a different marker, the 99mTechnetium-Icodextrin, to evaluate the distribution of the dialysate within the peritoneal cavity in peritoneal dialysis (PD) patients.
  
  
  METHODS
  99mTc-Icodextrin scintigraphy was performed in 16 PD patients. 0.5 ml of 7.5% Icodextrin solution was labeled with 74 megabecquerel (MBq) of 99mTc and then added to 2,000 ml of dialysate solution (2.5% dextrose). The peritoneum scintigraphy was performed by a SPECT gamma camera with the peritoneal cavity filled and after the complete drainage of the radio compound-dialysate mixture. The images were reviewed for evidence of peritoneal leaks, hernias, loculated fluid collections, and peritoneal membrane adhesions.
  
  
  RESULTS
  Abnormal findings were detected by 99mTc-Icodextrin scintigraphy in 4 (25%) out of 16 patients and included retroperitoneal (n = 1), diaphragmatic (n = 1) and inguinal (n = 1) leakages and peritoneal membrane adhesions (n = 1).
  
  
  CONCLUSIONS
  Peritoneum scintigraphy with 99mTc-Icodextrin is a useful method to detect some complications occurring during peritoneal dialysis; it offers excellent imaging to assess these complications.
authors.affiliation: Department of Specialist Surgery and Nephrology, University 'Federico II' of Naples, Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Argentino
authors.forename: Roberta
authors.initials: R
authors.lastname: Russo
authors.forename: Immacolata Daniela
authors.initials: ID
authors.lastname: Maresca
authors.forename: Tommasina
authors.initials: T
authors.lastname: Strazzullo
authors.forename: Andrea
authors.initials: A
authors.lastname: Memoli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sodo
authors.forename: Luigi
authors.initials: L
authors.lastname: Celentano
authors.forename: Bruno
authors.initials: B
authors.lastname: Memoli
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D005260:Female; D005936:Glucans / Q000493:pharmacokinetics / Q000633:toxicity; D005947:Glucose / Q000493:pharmacokinetics / Q000633:toxicity; D006552:Hernia, Inguinal / Q000000981:diagnostic imaging; D006801:Humans; D000077607:Icodextrin; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D010529:Peritoneal Cavity / Q000000981:diagnostic imaging*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D012187:Retroperitoneal Space / Q000000981:diagnostic imaging; D013909:Thorax / Q000000981:diagnostic imaging; D000267:Tissue Adhesions / Q000000981:diagnostic imaging; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015314:Dialysis Solutions; D005936:Glucans; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C000591385:technetium 99m icodextrin; D000077607:Icodextrin; D005947:Glucose