title: Interleukin-17 inhibits adult hippocampal neurogenesis.
abstract: Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.
authors.affiliation: 1] Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA [2] Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Xin
authors.affiliation: Department of Chemical Engineering, Arizona State University, Tempe, AZ, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors.forename: Dharshaun
authors.initials: D
authors.lastname: Turner
authors.affiliation: Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors.forename: Junxiang
authors.initials: J
authors.lastname: Yin
authors.affiliation: Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gan
authors.affiliation: 1] Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA [2] Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.affiliation: 1] Divisions of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA [2] Department of Physiology, Shantou University of Medical College, Shantou, Guangdong, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development*; D017353:Gene Deletion; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: C098680:Il17a protein, mouse; D020381:Interleukin-17