title: Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer.
abstract: Kruppel-like factor 2 (KLF2) expression is diminished in many malignancies. However, its expression and role in nonsmall-cell lung cancer (NSCLC) remain unknown. In this study, we found that KLF2 levels were decreased in NSCLC tissues compared with adjacent normal tissues. Its expression level was significantly correlated with TNM stages, tumor size, and lymph node metastasis. Moreover, patients with low levels of KLF2 expression had a relatively poor prognosis. Furthermore, knockdown of KLF2 expression by siRNA could promote cell proliferation, while ectopic expression of KLF2 inhibited cell proliferation and promoted apoptosis in NSCLC cells partly via regulating CDKN1A/p21 and CDKN2B/p15 protein expression. Our findings present that decreased KLF2 could be identified as a poor prognostic biomarker in NSCLC and regulate cell proliferation and apoptosis.
authors.affiliation: Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Yin
authors.forename: Ji-peng
authors.initials: JP
authors.lastname: Wang
authors.forename: Tong-peng
authors.initials: TP
authors.lastname: Xu
authors.forename: Wen-ming
authors.initials: WM
authors.lastname: Chen
authors.forename: Ming-de
authors.initials: MD
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Xia
authors.forename: Xin-xin
authors.initials: XX
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Kong
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.forename: Er-bao
authors.initials: EB
authors.lastname: Zhang
authors.forename: Yong-qian
authors.initials: YQ
authors.lastname: Shu
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: C096161:KLF2 protein, human; D051741:Kruppel-Like Transcription Factors