title: Functional polymorphisms of matrix metalloproteinases 1 and 9 genes in women with spontaneous preterm birth.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of functional MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB.
  
  
  METHODS
  A case-control study was conducted in 113 women with SPTB and 119 women with term delivery (control group). Genotyping of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods.
  
  
  RESULTS
  There were no statistically significant differences in the distribution of neither individual nor combinations of genotype and allele frequencies of MMP-1-1607 1G/2G and MMP-9-1562 C/T polymorphisms between women with SPTB and control women. Additionally, these polymorphisms do not contribute to any of the clinical characteristics of women with SPTB, including positive and negative family history of SPTB, gestational age at delivery, and maternal age at delivery, nor fetal birth weight.
  
  
  CONCLUSIONS
  We did not find the evidence to support the association of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with SPTB in European Caucasian women.
authors.affiliation: Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Nina
authors.identifier: 0000-0001-6725-7618
authors.initials: N
authors.lastname: Pereza
authors.affiliation: Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Pleša
authors.affiliation: Clinical Institute of Medical Genetics, Department of Gynaecology and Obstetrics, University Medical Center Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia.
authors.forename: Ana
authors.initials: A
authors.lastname: Peterlin
authors.affiliation: Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Center Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia.
authors.forename: Žiga
authors.initials: Ž
authors.lastname: Jan
authors.affiliation: Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Center Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Tul
authors.affiliation: Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Miljenko
authors.initials: M
authors.lastname: Kapović
authors.affiliation: Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Saša
authors.initials: S
authors.lastname: Ostojić
authors.affiliation: Clinical Institute of Medical Genetics, Department of Gynaecology and Obstetrics, University Medical Center Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D055815:Young Adult
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1