title: Accelerating immune reconstitution after hematopoietic stem cell transplantation.
abstract: Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored.
authors.affiliation: Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital , Houston TX, USA.
authors.forename: Ifigeneia
authors.initials: I
authors.lastname: Tzannou
authors.affiliation: Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital , Houston TX, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Leen
keywords: T cells; adoptive immunotherapy; hematopoietic stem cell transplantation; viral infections