title: Hepatitis B and human immunodeficiency virus co-infection.
abstract: Hepatitis B and human immunodeficiency virus (HBV and HIV) infection share transmission patterns and risk factors, which explains high prevalence of chronic HBV infection in HIV infected patients. The natural course of HBV disease is altered by the HIV infection with less chance to clear acute HBV infection, faster progression to cirrhosis and higher risk of liver-related death in HIV-HBV co-infected patients than in HBV mono-infected ones. HIV infected patients with chronic hepatitis B should be counseled for liver damage and surveillance of chronic hepatitis B should be performed to screen early hepatocellular carcinoma. Noninvasive tools are now available to evaluate liver fibrosis. Isolated hepatitis B core antibodies (anti-HBc) are a good predictive marker of occult HBV infection. Still the prevalence and significance of occult HBV infection is controversial, but its screening may be important in the management of antiretroviral therapy. Vaccination against HBV infection is recommended in non-immune HIV patients. The optimal treatment for almost all HIV-HBV co-infected patients should contain tenofovir plus lamivudine or emtricitabine and treatment should not be stopped to avoid HBV reactivation. Long term tenofovir therapy may lead to significant decline in hepatitis B surface Antigen. The emergence of resistant HBV strains may compromise the HBV therapy and vaccine therapy.
authors.affiliation: Bao-Chau Phung, Philippe Sogni, Odile Launay, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: Bao-Chau
authors.initials: BC
authors.lastname: Phung
authors.affiliation: Bao-Chau Phung, Philippe Sogni, Odile Launay, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sogni
authors.affiliation: Bao-Chau Phung, Philippe Sogni, Odile Launay, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D060085:Coinfection; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D015995:Prevalence; D013997:Time Factors; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D017325:Hepatitis B Vaccines
keywords: Chronic hepatitis B; Human immunodeficiency virus; Management; Occult hepatitis; Treatment