title: [Intraventricular injection of 5,7-dihydroxytryptamine alters neuronal activity of neurons in the medial prefrontal cortex of rat].
abstract: The present study is aimed to investigated the firing activity of pyramidal neurons and interneurons in the medial prefrontal cortex (mPFC) in rats with bilateral intraventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) by using in vivo extracellular recording. The results showed that the injection of 5,7-DHT reduced the 5-hydroxytryptamine (5-HT) levels in the mPFC and dorsal raphe nucleus in the rats. The firing rate of mPFC pyramidal neurons in rats with 5,7-DHT injection was significantly higher than that of normal rats, and the firing pattern of these neurons also changed significantly towards a more burst-firing, while the injection decreased the firing rate of mPFC interneurons and changed the firing pattern of the interneurons towards a more irregular. These results indicate that the lesions of the serotonergic neurons lead to the changes in the firing activity of mPFC pyramidal neurons and interneurons, suggesting that serotonergic system plays an important role in the regulation of the neuronal activity in the mPFC.
authors.affiliation: Medical College, Henan University of Science and Technology, Luoyang 471003, China. emmafll@163.com.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Fan
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Hu
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhou
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Li
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Jia
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Zhao
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000200:Action Potentials; D000818:Animals; D065847:Dorsal Raphe Nucleus / Q000166:cytology; D007276:Injections, Intraventricular; D007395:Interneurons / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000166:cytology*; D017966:Pyramidal Cells / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
chemical_list: D015116:5,7-Dihydroxytryptamine; D012701:Serotonin