title: Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester).
abstract: A three-step route was used to synthesize 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester) from 1,4,7,10-tetraazacyclododecane (cyclen). The overall time of reaction was reduced from a combined ~56 h to 2.3 h with an overall yield comparable to previously reported methods.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Hopper
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, United States.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen
keywords: DO2A-t-Bu Ester; cyclen; microwave; transfer hydrogenation