title: N-Phosphonyl/phosphinyl imines and group-assisted purification (GAP) chemistry/technology.
abstract: The development of environmentally benign, operationally simple, and economically viable synthetic methodologies has been a great challenge in organic synthesis. Group-assisted purification (GAP) chemistry was established to enable the synthesis of organic compounds without using traditional purification technologies, such as column chromatography and recrystallization. This concept/technology should encourage the synthetic community to make more efforts on searching for environmentally benign reagents and reactions to reduce the waste generated from silica and solvents, particularly toxic solvents; also, to reduce production/synthesis expenses, manpower, and energy. This review will discuss the GAP concept/technology and related reactions that were mainly conducted in the PI's laboratories after 2010.
authors.affiliation: Institute of Chemistry & BioMedical Sciences and Nanjing University, Nanjing 210093, P. R. China. guigenli@nju.edu.cn.
authors.forename: Guanghui
authors.initials: G
authors.lastname: An
authors.forename: Cole
authors.initials: C
authors.lastname: Seifert
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D007097:Imines / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D007097:Imines; D009943:Organophosphorus Compounds