title: [Features of cytogenetic changes in the human lymphoma U-937 cells after induction of apoptosis by tumor necrosis factor].
abstract: A comparative analysis of the frequency of cytogenetic abnormalities in cell population U-937 in control conditions and after exposure to tumor necrosis factor has been performed. We have found that in such treatment there is a maximum effect after 48 h, which is expressed in the stimulation of apoptosis and the accumulation of cells with micronuclei and binuclear cells. The induction of premature chromosome condensation is an early marker of the TNF influence. Changing the composition of the population by the number of chromosomes in the cell may lead to the emergence of a subline with new properties compared to the parental cell population.
authors.forename: O A
authors.initials: OA
authors.lastname: Kovaleva
authors.forename: Ia S
authors.initials: IaS
authors.lastname: Iasinskiĭ
authors.forename: N A
authors.initials: NA
authors.lastname: Bezdenezhnykh
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Kudriavets
mesh_terms: D000782:Aneuploidy; D020732:Cytogenetic Analysis; D006801:Humans; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D020298:U937 Cells
chemical_list: D014409:Tumor Necrosis Factor-alpha