title: May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer?
abstract: BACKGROUND
  The study aimed to evaluate changes in hematologic parameters, including white blood cell, platelet count, platelet indices, the platelet to lymphocyte and neutrophil to lymphocyte ratios in patients with early and advanced stages of epithelial ovarian cancers.
  
  
  METHODS
  The study included 100 patients with epithelial ovarian cancer who underwent primary staging exploratory laparotomy. Preoperative hematologic parameters, tumor histopathologic type, grade, stage and serum CA-125 levels were retrospectively analyzed. These parameters were compared between the patients with early (stage I-II) and advanced (stage III-IV) ovarian cancer.
  
  
  RESULTS
  White blood cell count and platelet indices, including mean platelet volume, platelet distribution width and platelet crit did not show a statistically significant difference between groups with early and advanced ovarian cancer. However, the neutrophil to lymphocyte ratio, platelet count, the platelet to lymphocyte ratio and CA-125 level showed a statistically significant difference between the two groups (p<0.05, p<0.01, p<0.001, p<0.01 respectively).
  
  
  CONCLUSIONS
  It was found that the neutrophil to lymphocyte ratio, platelet count and the platelet to lymphocyte ratio increased with the increasing stage of ovarian cancer. Furthermore, it was seen that the platelet to lymphocyte ratio is an independent prognostic factor related to the stage of epithelial ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey E-mail : arifkokcu@yahoo.com.
authors.forename: Arif
authors.initials: A
authors.lastname: Kokcu
authors.forename: Emel
authors.initials: E
authors.lastname: Kurtoglu
authors.forename: Handan
authors.initials: H
authors.lastname: Celik
authors.forename: Migraci
authors.initials: M
authors.lastname: Tosun
authors.forename: Erdal
authors.initials: E
authors.lastname: Malatyalıoglu
authors.forename: Ayse Zehra
authors.initials: AZ
authors.lastname: Ozdemir
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001792:Blood Platelets / Q000473:pathology*; D018284:Cystadenocarcinoma, Serous / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010051:Ovarian Neoplasms / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor