title: Similar survival in patients following heart transplantation receiving induction therapy using daclizumab vs. basiliximab.
abstract: BACKGROUND
  Induction therapy with interleukin-2 receptor antagonists has been established as an effective immunosuppressive strategy in the management of heart transplant (HTx) recipients. We compared outcomes following HTx in patients receiving basiliximab, daclizumab, or no induction therapy.
  
  
  RESULTS
  We investigated post-transplant prognosis of patients receiving basiliximab (n=67), daclizumab (n=98) or no induction therapy (n=70). Patients treated with daclizumab (50.3 ± 14.7 years) were younger than those receiving basiliximab (55.8 ± 11.2 years) or no induction therapy (54.9 ± 14.1 years; both P<0.05). Patients receiving either induction therapy showed better survival 1 year after HTx (95%) than those without induction therapy (82%; P<0.001). Survival was similar between patients receiving basiliximab and daclizumab. The incidence of acute cellular or antibody-mediated rejections did not differ among the groups. The main reason that patients did not receive induction therapy was ongoing infection (65.7%), which was more common in patients on ventricular assist device (VAD) support than those without VAD (76.1% vs. 45.8%; P=0.004). The VAD-related infection rate in the entire study cohort was 29.7% (35/118 VAD recipients).
  
  
  CONCLUSIONS
  Survival following HTx was worse in patients not receiving induction therapy. No differences were noted in survival or the incidence of rejection between the daclizumab- and basiliximab-treated groups. Induction therapy was less used in patients with infection, which was related to prior VAD support.
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Spencer T
authors.initials: ST
authors.lastname: Martin
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Tomoko S
authors.initials: TS
authors.lastname: Kato
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Maryjane
authors.initials: M
authors.lastname: Farr
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Jaclyn T
authors.initials: JT
authors.lastname: McKeen
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Faisal
authors.initials: F
authors.lastname: Cheema
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Mengxi
authors.initials: M
authors.lastname: Ji
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ross
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Halit
authors.initials: H
authors.lastname: Yerebakan
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Naka
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Takayama
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Restaino
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Mancini
authors.affiliation: Department of Pharmacy, Hartford Hospital, Hartford, CT (S.T.M.), USA; Heart Center, Juntendo University School of Medicine, Tokyo (T.S.K.), Japan; Department of Medicine, Division of Cardiology (T.S.K., M.F., M.J., A.R., S.R., D.M., P.C.S.), Department of Surgery, Division of Cardiothoracic Surgery (F.C., H.Y., Y.N., H.T.), Columbia University Medical Center, New York, NY; and Department of Pharmacy, Hackensack Medical Center, Hackensack, NJ (J.T.M.), USA.
authors.forename: P Christian
authors.initials: PC
authors.lastname: Schulze
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000077552:Basiliximab; D000077561:Daclizumab; D005260:Female; D016027:Heart Transplantation / Q000401:mortality*; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage*; D012189:Retrospective Studies; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D000077552:Basiliximab; D000077561:Daclizumab