title: Isolation of hydroxyoctaprenyl-1',4'-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat central nervous system.
abstract: Three polyprenyl-1',4'-hydroquinone derivatives, heptaprenyl-1',4'-hydroquinone (1), octaprenyl-1',4'-hydroquinone (2), and hydroxyoctaprenyl-1',4'- hydroquinone (3) were isolated from the marine sponge Sarcotragus spinosulus collected at Baia di Porto Conte, Alghero (Italy). Our findings indicate that the compounds isolated from S. spinosulus can significantly modulate the release of glutamate and acetylcholine in the rat hippocampus and cortex and might, therefore, represent the prototype of a new class of drugs regulating glutamatergic and cholinergic transmission in the mammalian central nervous system.
authors.forename: Angela
authors.initials: A
authors.lastname: Bisio
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fedele
authors.forename: Anna
authors.initials: A
authors.lastname: Pittaluga
authors.forename: Guendalina
authors.initials: G
authors.lastname: Olivero
authors.forename: Massimo
authors.initials: M
authors.lastname: Grilli
authors.forename: Jiayang
authors.initials: J
authors.lastname: Chen
authors.forename: Giacomo
authors.initials: G
authors.lastname: Mele
authors.forename: Nicola
authors.initials: N
authors.lastname: Malafronte
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
authors.forename: Fabio
authors.initials: F
authors.lastname: Leddae
authors.forename: Renata
authors.initials: R
authors.lastname: Manconi
authors.forename: Roberto
authors.initials: R
authors.lastname: Pronzato
authors.forename: Mario
authors.initials: M
authors.lastname: Marchi
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006873:Hydroquinones / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D011161:Porifera / Q000737:chemistry*; D051381:Rats
chemical_list: D006873:Hydroquinones; D018698:Glutamic Acid; D000109:Acetylcholine; C031927:hydroquinone