title: Leptin level lowers in proportion to the amount of aerobic work after four weeks of training in obesity.
abstract: Leptin values are higher in obesity. Physical exercise reduces fat mass (FM) and decreases leptin levels. Intensity of physical training seems to play a role in reducing circulating leptin. In 16 obese subjects (8 men and 8 women, age 38.6±3.9 years, BMI 35.9±1.8 kg/m(2)), leptin was sampled before and after 4 weeks of controlled training. Eight subjects (4 men and 4 women) performed an aerobic training schedule (Group A), the remainders an aerobic training program with a bout of work beyond the anaerobic threshold (AT) (Group B). Training determined a reduction in leptin levels in both groups, which was significant in Group A (12.2 vs. 27.8 μg/l, p<0.05), even when related to the change in FM (0.372 vs. 0.762 μg/l/kg, p<0.05). FM decreased significantly in Group B when compared to Group A (-7.4 vs. -2.6 kg, respectively, p<0.001). While in Group A the slight loss of FM was aggregated to a significant decrease in leptin levels, the opposite occurred in Group B. In Group A, leptin lowering was proportional to the amount of total work performed (p<0.001, R(2)=0.89). In obesity, a reduction is observed in leptin levels after short-term training, which is seemingly dissociated from concomitant decrease of FM. Aerobic training alone appears to be linked to a greater leptin reduction, which is well correlated with the amount of work performed.
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Salvadori
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Fanari
authors.affiliation: Division of Rehabilitation Medicine, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Brunani
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale 'A. Avogadro', Novara, Italy.|Division of General Medicine, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Marzullo
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Codecasa
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Tovaglieri
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cornacchia
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Palmulli
authors.affiliation: Division of Respiratory Rehabilitation, H. San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Longhini
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D020738:Leptin