title: New 15-membered tetraaza (N4) macrocyclic ligand and its transition metal complexes: spectral, magnetic, thermal and anticancer activity.
abstract: Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, (1)H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50=2.27-2.7, 8.33-31.1μg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50=13, 26μg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.
authors.affiliation: Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt. Electronic address: helboraey@yahoomail.com.
authors.forename: Hanaa A
authors.initials: HA
authors.lastname: El-Boraey
authors.affiliation: Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt.
authors.forename: Ohyla A
authors.initials: OA
authors.lastname: EL-Gammal
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008024:Ligands; D061986:MCF-7 Cells; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D060328:Magnetic Phenomena; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D028561:Transition Elements
keywords: Antitumor activity; IC(50); Macrocyclic metal complexes; Spectral studies; Tetraazamacrocyclic