title: Polymorphism of p53 gene codon 72 in endometrial cancer: correlation with tumor grade and histological type.
abstract: BACKGROUND
  Endometrial cancer is the fourth most common cancer among women in developed countries. Patients with endometrial cancer may benefit from systemic chemotherapy alone or in combination with targeted therapies if the disease is clinically diagnosed prior to spread and metastasis to other organs. The aim of this study was to evaluate the prognostic role of p53 polymorphism and its correlation with tumor grade in human uterine endometrial carcinomas.
  
  
  METHODS
  A total of 75 patients with endometrial carcinomas were studied for possible mutations in exon 4 of the p53 gene using polymerase chain reaction and restricting fragment length polymorphism techniques and sequencing.
  
  
  RESULTS
  In recent study, The rate of homozygote genotype of pro/pro or Arg/Arg in high grade group was higher than in comparison with low grade one. In addition samples that were undigested in RFLP, showed mutation in exone 4.
  
  
  CONCLUSIONS
  Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades.
authors.affiliation: Tabriz University of Medical Sciences, International Branche Aras, Tabriz, Iran E-mail : dastranjt@gmail.com.
authors.forename: Taiebeh
authors.initials: T
authors.lastname: Kafshdooz
authors.forename: Ali Dastranj
authors.initials: AD
authors.lastname: Tabrizi
authors.forename: Seyyed Mojtaba
authors.initials: SM
authors.lastname: Mohaddes Ardabili
authors.forename: Leila
authors.initials: L
authors.lastname: Kafshdooz
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Jalal
authors.initials: J
authors.lastname: Gharesouran
authors.forename: Ali
authors.initials: A
authors.lastname: Abdii
authors.forename: Hamideh
authors.initials: H
authors.lastname: Alizadeh
mesh_terms: D001483:Base Sequence; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D060787:Neoplasm Grading; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53