title: Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.
abstract: The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds. As much as 90% of the GH was released from the electrospun fibers within 6 h of incubation. Beyond this, the release was sustained for 24 h. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH-loaded sodium alginate/PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound-healing applications.
authors.affiliation: a Department of Chemical Engineering , Hanseo University , Chungcheongnam-Do , South Korea.
authors.forename: Saravanakumar
authors.initials: S
authors.lastname: Arthanari
authors.affiliation: a Department of Chemical Engineering , Hanseo University , Chungcheongnam-Do , South Korea.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Mani
authors.affiliation: c Seoryeong High School , Chungcheongnam-Do , South Korea.
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Jang
authors.affiliation: c Seoryeong High School , Chungcheongnam-Do , South Korea.
authors.forename: Je O
authors.initials: JO
authors.lastname: Choi
authors.affiliation: c Seoryeong High School , Chungcheongnam-Do , South Korea.
authors.forename: Yun Ho
authors.initials: YH
authors.lastname: Cho
authors.affiliation: d Garak High School , Seoul , South Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: b Hanseo Regional Innovation Center, Hanseo University , Chungcheongnam-Do , South Korea.|e Department of Business Administration , Sungkyunkwan University , Seoul , South Korea.
authors.forename: Seung Eun
authors.initials: SE
authors.lastname: Cha
authors.affiliation: a Department of Chemical Engineering , Hanseo University , Chungcheongnam-Do , South Korea.
authors.forename: Han Seok
authors.initials: HS
authors.lastname: Oh
authors.affiliation: c Seoryeong High School , Chungcheongnam-Do , South Korea.
authors.forename: Deok Han
authors.initials: DH
authors.lastname: Kwon
authors.affiliation: a Department of Chemical Engineering , Hanseo University , Chungcheongnam-Do , South Korea.|b Hanseo Regional Innovation Center, Hanseo University , Chungcheongnam-Do , South Korea.
authors.forename: Hyun Tae
authors.initials: HT
authors.lastname: Jang
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D024841:Fluoroquinolones / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077734:Gatifloxacin; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D024841:Fluoroquinolones; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D000077734:Gatifloxacin
keywords: drug delivery; electrospinning; gatifloxacin; nanofibers; sodium alginate