title: Trend of different molecular markers in the last decades for studying human migrations.
abstract: Anatomically modern humans are known to have widely migrated throughout history. Different scientific evidences suggest that the entire human population descended from just several thousand African migrants. About 85,000 years ago, the first wave of human migration was out of Africa, that followed the coasts through the Middle East, into Southern Asia via Sri Lanka, and in due course around Indonesia and into Australia. Another wave of migration between 40,000 and 12,000 years ago brought humans northward into Europe. However, the frozen north limited human expansion in Europe, and created a land bridge, "Bering land bridge", connecting Asia with North America about 25,000 years ago. Although fossil data give the most direct information about our past, it has certain anomalies. So, molecular archeologists are now using different molecular markers to trace the "most recent common ancestor" and also the migration pattern of modern humans. In this study, we have studied the trend of molecular markers and also the methodologies implemented in the last decades (2003-2014). From our observation, we can say that D-loop region of mtDNA and Y chromosome based markers are predominant. Nevertheless, mtDNA, especially the D-loop region, has some unique features, which makes it a more effective marker for tracing prehistoric footprints of modern human populations. Although, natural selection should also be taken into account in studying mtDNA based human migration. As per technology is concerned, Sanger sequencing is the major technique that is being used in almost all studies. But, the emergence of different cost-effective-and-easy-to-handle NGS platforms has increased its popularity over Sanger sequencing in studying human migration.
authors.affiliation: Molecular Medicine Laboratory, Department of Biotechnology, Assam University, Silchar, Pin-788011 Assam, India.
authors.forename: Sharbadeb
authors.initials: S
authors.lastname: Kundu
authors.affiliation: Molecular Medicine Laboratory, Department of Biotechnology, Assam University, Silchar, Pin-788011 Assam, India. Electronic address: drsankarghosh@gmail.com.
authors.forename: Sankar Kumar
authors.initials: SK
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D019143:Evolution, Molecular; D005819:Genetic Markers; D014644:Genetic Variation; D063426:Human Migration; D006801:Humans; D058974:Phylogeography; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA / Q000191:economics / Q000379:methods*
chemical_list: D004272:DNA, Mitochondrial; D005819:Genetic Markers
keywords: Human migration; Individual DNA barcode; Modern human population; Molecular marker; Trend of molecular markers; mtD-Loop