title: Clinicopathological and prognostic significance of CD24 overexpression in patients with gastric cancer: a meta-analysis.
abstract: OBJECTIVE
  The prognostic significance of CD24 expression for survival in patients with gastric cancer remains controversial. We conducted a meta-analysis to investigate the impact of CD24 expression on clinicopathological features and survival outcomes in gastric cancer.
  
  
  METHODS
  A comprehensive literature search of the electronic databases PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI; up to April 8, 2014) was performed for relevant studies using multiple search strategies. Correlations between CD24 expression and clinicopathological features and overall survival (OS) were analyzed.
  
  
  RESULTS
  A total of 1,041 patients with gastric cancer from 9 studies were included. The pooled odds ratios (ORs) indicated CD24 expression was associated with tumor depth (OR = 0.45, 95% confidence interval [CI]  = 0.32-0.63; P<0.00001), status of lymph nodes (OR = 0.40, 95% CI = 0.25-0.64; P = 0.0001) and tumor node metastasis (TNM) stage (OR = 0.56, 95% CI = 0.41-0.77; P = 0.0003). The pooled hazard ratio (HR) for OS showed overexpression of CD24 reduced OS in gastric cancer (HR = 1.99, 95% CI = 1.29-3.07, P = 0.002). Whereas, combined ORs showed that CD24 expression had no correlation with tumor differentiation or Lauren classifications.
  
  
  CONCLUSIONS
  CD24 overexpression in patients with gastric cancer indicated worse survival outcomes and was associated with common clinicopathological poor prognostic factors.
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Jing-Xun
authors.initials: JX
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Han-Xiang
authors.initials: HX
authors.lastname: An
mesh_terms: D051927:CD24 Antigen / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*
chemical_list: D051927:CD24 Antigen