title: Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees.
abstract: Genetic Analysis Workshop 18 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence data from a pedigree-based sample. In this article we present an overview of the data sets and the contributions that analyzed these data. The family data, donated by the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples Consortium, included sequence-level genotypes based on sequencing and imputation, genome-wide association genotypes from prior genotyping arrays, and phenotypes from longitudinal assessments. The contributions from individual research groups were extensively discussed before, during, and after the workshop in theme-based discussion groups before being submitted for publication.
authors.affiliation: Department of Genetic Epidemiology, University Medicine Göttingen, University of Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Bickeböller
authors.affiliation: Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
authors.forename: Julia N
authors.initials: JN
authors.lastname: Bailey
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8S 4K1, Canada.
authors.forename: Joseph
authors.initials: J
authors.lastname: Beyene
authors.affiliation: David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
authors.forename: Rita M
authors.initials: RM
authors.lastname: Cantor
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Cordell
authors.affiliation: Department of Medicine and Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Culverhouse
authors.affiliation: Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA.
authors.forename: Corinne D
authors.initials: CD
authors.lastname: Engelman
authors.affiliation: Department of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Fardo
authors.affiliation: Indian Statistical Institute, Kolkata 700108, West Bengal, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany.
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.affiliation: Institute of Medical Biometry and Informatics, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Justo
authors.initials: J
authors.lastname: Lorenzo Bermejo
authors.affiliation: Centre for Genetic Origins of Health and Disease, Statistical Genetics, University of Western Australia, Crawley 6009, Australia.
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Melton
authors.affiliation: Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO 80217, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Santorico
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Glen A
authors.initials: GA
authors.lastname: Satten
authors.affiliation: Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Mathematics, Computer Science and Statistics, Dordt College, Sioux Center, IA 51250, USA.
authors.forename: Nathan L
authors.initials: NL
authors.lastname: Tintle
authors.affiliation: Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany ; Zentrum für Klinische Studien, Universität zu Lübeck, 23562 Lübeck, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy