title: Association between single nucleotide polymorphisms in the OPRM1 gene and intraoperative remifentanil consumption in northern Chinese women.
abstract: BACKGROUND
  Recent studies have suggested that some single nucleotide polymorphisms (SNPs) in the human µ-opioid receptor gene (OPRM1) affect the postoperative analgesic efficacy of opioids and their side effects. In this study, we assessed the association between SNPs in the OPRM1 gene and intraoperative remifentanil consumption as well as perioperative side effects during gynecological hysteroscopic surgery in women from Northern China.
  
  
  METHODS
  We analyzed 178 women undergoing gynecological hysteroscopic surgery. SNP genotyping was performed using the SNaPshot method. The state anxiety index (SAI) and pressure pain threshold (PPT) of all patients were assessed preoperatively. Monitored anesthesia care was maintained by the intravenous infusion of remifentanil. Intraoperative remifentanil usage and perioperative side effects were recorded. Statistical analyses were performed using SPSS software.
  
  
  RESULTS
  Patients carrying one or two copies of the minor allele (G allele) of rs558025 required significantly more intraoperative remifentanil than patients without the minor allele (p = 0.001, corrected p = 0.006). There were no significant associations between the six SNPs and various clinical characteristics. No significant associations between the six SNPs and PPT or SAI were found in our study.
  
  
  CONCLUSIONS
  SNP rs558025 in the OPRM1 gene was associated with intraoperative remifentanil consumption during gynecological hysteroscopic surgery in our subjects.
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Dongxue
authors.initials: D
authors.lastname: Hu
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Hongjie
authors.initials: H
authors.lastname: Xi
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015907:Hysteroscopy; D010146:Pain / Q000188:drug therapy* / Q000235:genetics; D059035:Perioperative Period; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D011184:Postoperative Period; D017450:Receptors, Opioid, mu / Q000235:genetics*; D000077208:Remifentanil
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; C485764:OPRM1 protein, human; D010880:Piperidines; D017450:Receptors, Opioid, mu; D000077208:Remifentanil