title: Association between interleukin 1 receptor antagonist gene 86-bp VNTR polymorphism and sepsis: a meta-analysis.
abstract: OBJECTIVE
  Many studies have focused on the relationship between interleukin 1 receptor antagonist (IL1RN) gene 86-bp VNTR polymorphism and sepsis, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between IL1RN 86-bp VNTR polymorphism and risk of sepsis and sepsis-related mortality.
  
  
  METHODS
  Relevant publications were searched in several widely used databases and six eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between IL1RN 86-bp VNTR polymorphism and risk of sepsis and sepsis-related mortality.
  
  
  RESULTS
  Significant associations between IL1RN 86-bp VNTR polymorphism and sepsis risk were observed in both overall meta-analysis for L2 versus 22 (OR=0.75, 95% CI=0.59-0.94) and severe sepsis subgroup for LL+L2 versus 22 (OR=0.67, 95% CI=0.47-0.93). L stands for long alleles containing three to six repeats; 2 stands for short allele containing two repeats. However, no significant sepsis mortality variation was detected for all genetic models.
  
  
  CONCLUSIONS
  According to the results of our meta-analysis, the IL1RN 86-bp VNTR polymorphism probably associates with sepsis risk but not with sepsis-related mortality.
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Pan
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Lixiao
authors.initials: L
authors.lastname: Xu
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Guanghao
authors.initials: G
authors.lastname: Su
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou 215003, China. Electronic address: wj196312@vip.163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000483:Alleles; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics* / Q000276:immunology; D018598:Minisatellite Repeats; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017472:Receptors, Interleukin-1 / Q000235:genetics* / Q000276:immunology; D012306:Risk; D018805:Sepsis / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D016019:Survival Analysis
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1
keywords: Interleukin 1 receptor antagonist; Meta-analysis; Mortality; Polymorphism; Sepsis