title: [Bone and Calcium Research Update 2015. Metabolic crosstalk bone and other organs].
abstract: Bone homeostasis is maintained by bone formation and bone resorption. The identification that nervous system controls bone metabolism through leptin deficient mice studies opened a new field in bone biology. Notably, sympathetic and parasympathetic nerve system regulate bone metabolism. In addition, sensory nerve system also has been shown to be involved in the regulation of bone homeostasis. On the other hand, recent studies reported that bone derived hormones, such as osteocalcin or fibroblast growth factor 23, regulate systemic metabolism. Based on these findings, currently the bone-organ crosstalk has been noted.
authors.affiliation: Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ochi
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000378:metabolism*
chemical_list: D020738:Leptin; D002118:Calcium