title: Methods to Make Homogenous Antibody Drug Conjugates.
abstract: Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs.
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
authors.forename: Toni
authors.initials: T
authors.lastname: Kline
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Steiner
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Penta
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
authors.forename: Aaron K
authors.initials: AK
authors.lastname: Sato
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Hallam
authors.affiliation: Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA. gyin@sutrobio.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Yin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry*; D015202:Protein Engineering; D054852:Small Molecule Libraries / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D018796:Immunoconjugates; D054852:Small Molecule Libraries
keywords: antibody drug conjugates (ADCs); homogenous conjugates; protein engineering; site-specific conjugation; targeted delivery