title: Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk.
abstract: Aim: Cell cycle regulatorcyclin D1 (CCND1)is a pivotal regulator for G1/S phase transition, playing a critical part in initiation of carcinogenesis. Triple negative breast cancer comprises a very heterogeneous group of cancer cells, but little is known about what is wrong in the genome of these patients. This study investigated contribution ofCCND1genotype to individual triple negative breast cancer susceptibility. Materials: In all, 2464 native Taiwan subjects consist of 1232 breast cancer cases and 1232 controls were enrolled in a hospital-based, case-control study.CCND1A870G (rs9344) genotyping was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Risk-stratified analyses correlated genotype and age-related characteristics of breast cancer subgroups. Results: No significant difference was found between patient and control groups in distribution of genotypic and allelic frequencies inCCND1genotype, yetCCND1A870G (rs9344) GG genotype was far less prevalent in breast cancer patients younger than 55 years (OR=0.62, 95%CI=0.43-0.89,P=0.0362), with first menarche earlier than 12.2 years (OR=0.61, 95% CI=0.42-0.87, P=0.0241), with menopause earlier than 49.0 years (OR=0.57, 95%CI=0.39-0.82,P=0.0093), or showing triple-negative breast cancer (OR=0.28, 95%CI=0.13-0.62,P=0.0006). Such valuable findings suggestCCND1A870G (rs9344) as a predictive marker for triple negative breast cancer in Taiwanese women; the authors sincerely hope these help us fight the toughest subtype in clinical management.
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan.
authors.forename: Liang-Chih
authors.initials: LC
authors.lastname: Liu
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan ; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Chen-Hsien
authors.initials: CH
authors.lastname: Su
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan.
authors.forename: Hwei-Chung
authors.initials: HC
authors.lastname: Wang
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan ; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan ; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Ming-Chei
authors.initials: MC
authors.lastname: Maa
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan.
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, 404 Taichung, Taiwan ; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan ; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
keywords: Cyclin D1; Genotype; Triple negative breast cancer