title: Analysis of signaling pathways in recurrent breast cancer.
abstract: Breast cancer remains the second largest cause of death in women from cancer. By analyzing gene expression profiles in samples from breast cancer patients, 844 differentially expressed genes (DEGs) were identified in breast cancer metastasis. The 10 most significant signaling pathways identified through enrichment analysis contained DEGs were involved in oxidative phosphorylation, DNA replication, extracellular matrix-receptor interactions and others. Furthermore, survival analysis demonstrated that 5 of these signaling pathways were closely related to the survival time of breast cancer patients including basal transcription factors, cell cycle, ECM-receptor interaction, spliceosome, and DNA replication. Our findings increase the understanding of the network of signaling pathways involved in breast cancer metastasis and may provide theoretical support for further therapeutic study.
authors.affiliation: Breast Cancer Diagnosis and Treatment Center Henan, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Wu
authors.affiliation: Gastrointestinal Surgery Department, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: T J
authors.initials: TJ
authors.lastname: Yang
authors.affiliation: Gastrointestinal Surgery Department, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: P
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China linmeiwangzz@hotmail.com.
authors.forename: W
authors.initials: W
authors.lastname: Ma
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D016019:Survival Analysis; D013997:Time Factors