title: [Single nucleotide polymorphisms in lung cancer patients and cisplatin treatment].
abstract: Lung cancer is a major cause of mortality worldwide and non-small cell lung cancer (NSCLC) accounts for over 80% of all cases of lung cancer. Despite efforts to develop and improve early screening methods, the majority of tumors are detected at advanced stages. For over 30 years, cisplatin (CDDP), or any of its analogues, has been used in the treatment of many types of tumors, including lung cancer. The use of platinum-based chemotherapeutics is limited by their toxicity and later on by the development of chemoresistance by tumor cells. The molecular mechanisms of CDDP resistance are not fully resolved. Genetic variants of DNA repair proteins, as well as proteins involved in drug accumulation or detoxification, play a crucial role in determining the cell's response to platinum-based chemotherapy. The identification of selected gene polymorphisms could improve the prognosis of a patient's response to therapy and overall survival. In this review we will focus on the gene polymorphisms involved in CDDP resistance, in particular in lung tumors, and discuss their potential as prognosis and survival markers.
authors.affiliation: Katedra i Zakład Biochemii i Biologii Molekularnej, Uniwersytet Medyczny w Lublinie.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stenzel-Bembenek
authors.affiliation: Katedra i Klinika Chirurgii Klatki Piersiowej, Uniwersytet Medyczny w Lublinie.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Sagan
authors.affiliation: Katedra i Zakład Biochemii i Biologii Molekularnej, Uniwersytet Medyczny w Lublinie; Katedra i Klinika Gastroenterologii z Pracownią Endoskopową, Uniwersytet Medyczny w Lublinie.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Guz
authors.affiliation: Katedra i Zakład Biochemii i Biologii Molekularnej, Uniwersytet Medyczny w Lublinie; Oddział Laryngologiczny, Szpital MSW w Lublinie.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Stepulak
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use*; D004268:DNA-Binding Proteins / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D002945:Cisplatin