title: Anti-tumor activities of triterpenes from Syzygium kusukusense.
abstract: In this study, we report the isolation from the stem of Syzygium kusukusense of five triterpenes, 2α-hydroxybetulinic acid (1), betulinic acid (2), platanic acid (3), ursolic acid (4), and hyptatic acid A (5). All were identified for the first time from this indigenous plant of Taiwan. Assessment of the cytotoxic activities of these compounds against a panel of human tumor cell lines, including MCF-7 breast, PC-3 prostate, and SCC2095 oral squamous cell cancers, revealed the high potency of compounds 1 (IC50, 5.7 - 7.6 μM) and, especially, 4 (IC50, 1.7 - 3.7 μM) in suppressing cell viability, which warrants further mechanistic investigations.
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Bai
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Lin
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Weng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D053978:Pentacyclic Triterpenes; D018547:Plant Stems / Q000737:chemistry; D027842:Syzygium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C087107:platanic acid