title: Graphene oxide bound silica for solid-phase extraction of 14 polycyclic aromatic hydrocarbons in mainstream cigarette smoke.
abstract: Polycyclic aromatic hydrocarbons (PAHs) were considered as a source of carcinogenicity in mainstream cigarette smoke (MSS). Accurate quantification of these components was necessary for assessing public health risk. In our study, a solid-phase extraction (SPE) method using graphene oxide (GO) bound silica as adsorbent for purification of 14 PAHs in MSS was developed. During SPE process, large matrices interferences of MSS were adsorbed on SPE column. The result of FTIR spectra demonstrated that these matrices interferences were adsorbed on GO mainly through OH and CO groups. The concentrations of PAHs in MSS extract were determined by gas chromatography-mass spectrometry (GC-MS). The limit of detection (LOD) and limit of quantification (LOQ) of the developed method for 14 PAHs ranged from 0.05 to 0.36 ng/cig and 0.17 to 1.19 ng/cig, respectively. The accuracy of the measurement of 14 PAHs was from 73 to 116%. The relative standard deviations of intra- and inter-day analysis were less than 7.8% and 13.9%, respectively. Moreover, the developed method was successfully applied for analysis of real cigarette containing 1R5F reference cigarette and 12 top-selling commercial cigarettes in China.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China; Beijing Third Class Tobacco Supervision Station, Beijing 101121, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Shi
authors.affiliation: Beijing Third Class Tobacco Supervision Station, Beijing 101121, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Yan
authors.affiliation: Beijing Third Class Tobacco Supervision Station, Beijing 101121, China.
authors.forename: Tongguang
authors.initials: T
authors.lastname: Xu
authors.affiliation: Beijing Third Class Tobacco Supervision Station, Beijing 101121, China.
authors.forename: Dongye
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China. Electronic address: zhuyf@mail.tsinghua.edu.cn.
authors.forename: Yongfa
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Beijing Third Class Tobacco Supervision Station, Beijing 101121, China. Electronic address: zhoujun100@sohu.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000327:Adsorption; D008401:Gas Chromatography-Mass Spectrometry; D006108:Graphite; D057230:Limit of Detection; D010087:Oxides; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000302:isolation & purification; D012822:Silicon Dioxide; D012906:Smoke / Q000032:analysis*; D052616:Solid Phase Extraction / Q000379:methods*; D014026:Nicotiana
chemical_list: D010087:Oxides; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke; D012822:Silicon Dioxide; D006108:Graphite
keywords: Gas chromatography–mass spectrometry; Graphene oxide; Polycyclic aromatic hydrocarbons; Solid phase extraction