title: Construction of selenium nanoparticles/β-glucan composites for enhancement of the antitumor activity.
abstract: We report on a green procedure for the stabilization of selenium nanoparticles (SeNPs) by a naturally occurring β-glucan with triple helical conformation known as Lentinan (t-LNT) in water after denaturing into single chains (s-LNT) at 140 °C. The results demonstrated that the s-LNT can interact with SeNPs through Se-O-H interaction. Transmission electron microscopy (TEM), energy dispersive X-ray (EDX) spectra, UV/vis, X-ray diffraction (XRD) and dynamic light scattering (DLS) showed that s-LNT coated SeNPs to form a stable nano-composite Se/s-LNT, leading to good dispersion of SeNPs. Especially, the as-prepared Se/s-LNT composite in the solution could remain homogeneous and translucent for 30 days without any precipitates. Different size distribution of SeNPs was prepared by simply controlling the concentrations of selenite sodium and the corresponding reducing agent ascorbic acid. The size effect of SeNPs on anti-tumor activity was revealed that the SeNPs with more evenly particle size distribution show the higher anticancer activity.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuchang Luojiashan, Wuhan 430072, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Jia
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuchang Luojiashan, Wuhan 430072, China.
authors.forename: Qingye
authors.initials: Q
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuchang Luojiashan, Wuhan 430072, China.
authors.forename: Siwei
authors.initials: S
authors.lastname: Zou
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuchang Luojiashan, Wuhan 430072, China. Electronic address: xuxj@whu.edu.cn.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Xu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuchang Luojiashan, Wuhan 430072, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007912:Lentinan / Q000737:chemistry / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012643:Selenium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D007912:Lentinan; D012643:Selenium
keywords: Antitumor activity; Selenium nanoparticles; Triple helical lentinan