title: Hijacking of death receptor signaling by bacterial pathogen effectors.
abstract: Death receptors such as Tumor necrosis factor receptor 1, FAS and TNF-associated apoptosis-inducing ligand-R1/2 play a major role in counteracting with bacterial pathogen infection through regulation of inflammation and programmed cell death. The highly regulated death receptor signaling is frequently targeted by gram-negative bacterial pathogens such as Salmonella, Shigella, enteropathogenic Escherichia coli and enterohamorrhagic Escherichia coli, which harbor a conserved type III secretion system that delivers a repertoire of effector proteins to manipulate host signal transductions for their own benefit. This review focuses on how bacterial gut pathogens hijack death receptor signaling to inhibit host NF-κB and programmed cell death pathways.
authors.affiliation: Taihe Hospital, Hubei University of Medicine, #32 Renmin South Rd, Shiyan, 442000, Hubei, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Jiaqingzi
authors.initials: J
authors.lastname: Hu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Hu
authors.forename: Shan
authors.initials: S
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D001426:Bacterial Proteins / Q000502:physiology*; D058947:Bacterial Secretion Systems; D004755:Enterobacteriaceae / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D053218:Receptors, Death Domain / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D016328:NF-kappa B; D053218:Receptors, Death Domain