title: Higher plasma lipopolysaccharide concentrations are associated with less favorable phenotype in overweight/obese men.
abstract: OBJECTIVE
  Lipopolysaccharide (LPS) from the outer membrane of gram-negative bacteria might be an inflammation trigger in adipose tissue. It has recently been proposed that there is a link between adipose tissue distribution and blood LPS. However, the number of studies on this topic is scarce, and further investigation in humans is required. In this study, we explored the association between plasma LPS concentrations and body fat distribution, as well as the biochemical parameters that may indicate the presence of metabolic disorders.
  
  
  METHODS
  Sixty-seven young adult men with body mass index of 26-35 kg/m(2) were evaluated. Anthropometry, body composition and body fat distribution, blood pressure, energy expenditure, physical activity level, dietary intake, and biochemical parameters were assessed.
  
  
  RESULTS
  Men with median plasma LPS ≥ 0.9 EU/mL presented higher sagittal abdominal diameter, trunk fat percentage, and android fat percentage, and mass, insulin and alanine aminotransferase concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), and beta cell dysfunction (HOMA-B) than those with lower plasma LPS. LPS correlated positively with the trunk fat percentage, and android fat percentage, and mass, insulin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase concentrations, as well as HOMA-IR and HOMA-B.
  
  
  CONCLUSIONS
  Our results suggest that a higher plasma LPS concentration is associated with a less favorable phenotype as characterized by higher central adiposity, higher values of HOMA-IR, and beta cell function impairment in overweight/obese men.
authors.affiliation: Departamento de Nutrição, Universidade Federal de Juiz de Fora, Bairro Martelos, s/n, Juiz de Fora, Minas Gerais, CEP 36036-330, Brazil. apboroni@yahoo.com.br.
authors.forename: Ana Paula Boroni
authors.initials: AP
authors.lastname: Moreira
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Raquel Duarte Moreira
authors.initials: RD
authors.lastname: Alves
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Tatiana Fiche Salles
authors.initials: TF
authors.lastname: Teixeira
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Viviane Silva
authors.initials: VS
authors.lastname: Macedo
authors.affiliation: Department of General Biology, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Leandro Licursi
authors.initials: LL
authors.lastname: de Oliveira
authors.affiliation: Department of Pharmacy and Nutrition, Universidade Federal do Espírito Santo, Vitória, Brazil.
authors.forename: Neuza Maria Brunoro
authors.initials: NM
authors.lastname: Costa
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: do Carmo Gouveia Peluzio
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Mattes
authors.affiliation: Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil.
authors.forename: Rita
authors.initials: R
authors.lastname: de Cássia Gonçalves Alfenas
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure; D001823:Body Composition; D050218:Body Fat Distribution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D010641:Phenotype; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D007328:Insulin; D008070:Lipopolysaccharides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
keywords: Abdominal obesity; Homeostasis model assessment; Insulin; Lipopolysaccharide