title: Placental miR-106a∼363 cluster is dysregulated in preeclamptic placenta.
abstract: Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we performed a microarray assay to explore miRNA expression profile in the placenta, and found 11 upregulated and 7 downregulated miRNAs in preeclampsia. miR-363, plus other 5 member of miR-106a∼363 cluster was further examined and validated. These findings would facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia.
authors.affiliation: Department of Obstetrics, Affiliated Hospital of Weifang Medical University, Weifang, 261041, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Public Health College, Weifang Medical University, Weifang 261053, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: N
authors.initials: N
authors.lastname: Ren
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: M
authors.initials: M
authors.lastname: Xie
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Gao
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Pan
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang 261041, China.
authors.forename: C
authors.initials: C
authors.lastname: Ren
authors.affiliation: School of Biological Sciences, Weifang Medical University, Weifang 261053, China. Electronic address: yangweiwei0127@gmail.com.
authors.forename: W
authors.initials: W
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D046228:Microarray Analysis; D005810:Multigene Family / Q000235:genetics*; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D059467:Transcriptome
chemical_list: C542541:MIRN106 microRNA, human; C574861:MIRN363 microRNA, human; D035683:MicroRNAs
keywords: Placenta; Preeclampsia; miR-106a∼363