title: "Gender specific medicine": a focus on gender-differences in hypertension.
abstract: Hypertension, worldwide considered the most frequent disease, is one of the major contributors to the leading cause of death in women: cardiovascular diseases. Until recently, women have been underestimated in clinical trials. Menopause represents the moment when the so-called "female advantage" is reversed. This review is presenting some gender-specific differences that explain why women are more exposed, especially if obesity is present in post-menopausal women, to hypertension complications. The smaller percentage of optimal controlled blood pressure values in hypertensive women is explained by a lesser adherence to lifestyle modifications and to drug therapy. All these gender-associated differences must be considered in hypertension management of women.
authors.forename: H
authors.initials: H
authors.lastname: Bălan
authors.forename: Livia
authors.initials: L
authors.lastname: Popescu
mesh_terms: D052242:Adiponectin / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008019:Life Style; D008297:Male; D009765:Obesity / Q000453:epidemiology; D012737:Sex Factors; D016387:Women's Health
chemical_list: D052242:Adiponectin