title: [Relationship between atherosclerotic plaque characteristics and extracellular matrix metalloproteinase inducer and urokinase-type plasminogen activator in patients with coronary artery disease].
abstract: OBJECTIVE
  To explore the association between extracellular matrix metalloproteinase inducer (EMMPRIN) and urokinase-type plasminogen activator (uPA) and the severity of coronary artery lesions in coronary heart disease (CHD) patients.
  
  
  METHODS
  This study enrolled 88 patients with acute coronary syndrome (ACS) and 46 patients with stable angina pectoris (SAP). The mean fluorescence intensity (MFI) of EMMPRIN on monocytes of peripheral blood (PBMCs) were examined by flow cytometry. uPA in serum was measured with ELISA . 64-slice spiral computed tomography coronary artery imaging was performed in 108 CHD patients. Coronary artery plaques were divided into type I (33 patients), type II (59 patients) and type III (44 patients) through plaque morphology characteristics according to coronary angiography. Coronary artery plaques were divided into soft (42 patients), fibrous (34 patients) and calcified plaque (32 patients) according to CT characteristics.
  
  
  RESULTS
  (1) Type II plaque (48 patients) and soft plaque (35 patients) were the major plaque types in the ACS patients, while type Iplaque (20 patients) and type III plaque (17 patients) and fibrous plaque (16 patients) and calcified plaque (22 patients) were the major plaque types in the SAP patients. (2) The EMMPRIN expression and uPA levels were significantly higher in typeII plaque group (EMMPRIN MFI: 11.61 ± 0.81, uPA: (0.89 ± 0.17) mg/L) than those in the typeIplaque group (EMMPRIN MFI: 6.65 ± 1.32, uPA: (0.53 ± 0.06) mg/L) and in the type III plaque group (EMMPRIN MFI: 9.47 ± 1.16, uPA:(0.56 ± 0.04) mg/L, all P < 0.05). The EMMPRIN expression was higher in the typeIII plaque group (MFI: 9.47 ± 1.16) than in the typeIplaque group (MFI:6.65 ± 1.32, P < 0.05), but uPA levels were similar between the 2 groups ((0.56 ± 0.04) mg/L vs. (0.53 ± 0.06) mg/L). (3) The EMMPRIN expression and uPA levels in the soft plaque group (EMMPRIN MFI:11.37 ± 0.76, uPA: (0.97 ± 0.12)mg/L) were significantly higher than those in the fibrous plaque group (EMMPRIN MFI: 8.93 ± 1.21), uPA:(0.52 ± 0.09) mg/L) and calcified plaque group (EMMPRIN MFI: 6.94 ± 1.19, uPA:(0.49 ± 0.12) mg/L, P < 0.05). The EMMPRIN expression in the fibrous plaque group (MFI:8.93 ± 1.21) was higher than in the calcified plaque group (MFI:6.94 ± 1.19, P < 0.05), but uPA levels were similar between the two groups.
  
  
  CONCLUSIONS
  Higher EMMPRIN expression and uPA levels were associated with plaque instability, which might be used to evaluate plaque stability in CHD patients.
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China. Email: doctorylixia@aliyun.com.cn.
authors.forename: Lixia
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China.
authors.forename: Xiangquan
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China.
authors.forename: Ruiwei
authors.initials: R
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Kunming General Hospital, Chengdu Military Command, Kunming 650032, China.
authors.forename: Jinshan
authors.initials: J
authors.lastname: Ye
mesh_terms: D054058:Acute Coronary Syndrome; D051926:Basigin; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D005434:Flow Cytometry; D006801:Humans; D020782:Matrix Metalloproteinases; D009000:Monocytes; D058226:Plaque, Atherosclerotic; D014568:Urokinase-Type Plasminogen Activator
chemical_list: D051926:Basigin; D014568:Urokinase-Type Plasminogen Activator; D020782:Matrix Metalloproteinases