title: Molecular mechanisms of hepatic apoptosis regulated by nuclear factors.
abstract: Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The mechanism of hepatic apoptosis is not well understood. Hepatic apoptosis alters relative levels of nuclear factors such as Foxa2, NF-κB, C/EBPβ, and p53. Regulation of nuclear factors modulates the degree of hepatic apoptosis and the progression of liver disease. Nuclear factors have distinctive mechanisms to mediate hepatic apoptosis. The modification of nuclear factors is a novel therapeutic strategy for liver disease as demonstrated by pre-clinical models and clinical trials.
authors.affiliation: Departments of Surgery, University of Illinois College of Medicine, Peoria, IL 61605, USA. Electronic address: kewang@uic.edu.
authors.forename: Kewei
authors.initials: K
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D051542:Hepatocyte Nuclear Factor 3-beta / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016328:NF-kappa B / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; C496502:FOXA2 protein, human; D016328:NF-kappa B; D016159:Tumor Suppressor Protein p53; D051542:Hepatocyte Nuclear Factor 3-beta
keywords: C/EBPβ; Foxa2; Hepatic apoptosis; NF-κB; Nuclear factors; p53