title: Virilizing adrenal oncocytoma in a 9-year-old girl: rare neoplasm with an intriguing postoperative course.
abstract: Adrenal oncocytoma is an extremely rare neoplasm, which is mostly non-functional. Only five cases of childhood adrenal oncocytoma have been described so far, all of which were hormonally active. Currently, guidelines for management and follow-up are not available. We report a 9-year-old girl with benign adrenal oncocytoma, presenting with severe short-term virilization. After diagnostic work-up the patient underwent laparoscopic unilateral adrenalectomy. For the first 2 weeks following surgery she suffered marked mood swings, irritability and fatigue. There were no other clinical and/or laboratory abnormalities except the rapid drop-down of androgen levels to normal values. Follow-up showed no signs of recurrence and in the absence of signs of adrenal insufficiency, we speculate that, the rapid drop of androgen levels after removal of the tumor might be the reason for the deteriorated psychoemotional condition of our patient.
authors.forename: Galina
authors.initials: G
authors.lastname: Yordanova
authors.forename: Violeta
authors.initials: V
authors.lastname: Iotova
authors.forename: Kalin
authors.initials: K
authors.lastname: Kalchev
authors.forename: Krasimir
authors.initials: K
authors.lastname: Ivanov
authors.forename: Boyan
authors.initials: B
authors.lastname: Balev
authors.forename: Nikola
authors.initials: N
authors.lastname: Kolev
authors.forename: Anton
authors.initials: A
authors.lastname: Tonev
authors.forename: Wolter
authors.initials: W
authors.lastname: Oosterhuis
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D011184:Postoperative Period; D014770:Virilism