title: Molecular mechanisms governing Arabidopsis iron uptake.
abstract: Plants are the principal source of dietary iron (Fe) for most of Earth's population and Fe deficiency can lead to major health problems. Developing strategies to improve plant Fe content is a challenge because Fe is essential and toxic and therefore regulating Fe uptake is crucial for plant survival. Acquiring soil Fe relies on complex regulatory events that occur in root epidermal cells. We review recent advances in elucidating many aspects of the regulation of Fe acquisition. These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1). We outline future challenges and propose strategies, such as exploiting natural variation, to further expand our knowledge.
authors.affiliation: Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany.
authors.forename: Tzvetina
authors.initials: T
authors.lastname: Brumbarova
authors.affiliation: Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany; Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D-40225 Düsseldorf, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Bauer
authors.affiliation: Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany. Electronic address: rumen.ivanov@uni-duesseldorf.de.
authors.forename: Rumen
authors.initials: R
authors.lastname: Ivanov
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D007501:Iron / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; D027682:Cation Transport Proteins; C099651:IRT1 protein, Arabidopsis; D007501:Iron
keywords: IRT1 trafficking; iron uptake; phytohormones; transcriptional regulation