title: Glycerophosphate-based chitosan thermosensitive hydrogels and their biomedical applications.
abstract: Chitosan is non-toxic, biocompatible and biodegradable polysaccharide composed of glucosamine and derived by deacetylation of chitin. Chitosan thermosensitive hydrogel has been developed to form a gel in situ, precluding the need for surgical implantation. In this review, the recent advances in chitosan thermosensitive hydrogels based on different glycerophosphate are summarized. The hydrogel is prepared with chitosan and β-glycerophosphate or αβ-glycerophosphate which is liquid at room temperature and transits into gel as temperature increases. The gelation mechanism may involve multiple interactions between chitosan, glycerophosphate, and water. The solution behavior, rheological and physicochemical properties, and gelation process of the hydrogel are affected not only by the molecule weight, deacetylation degree, and concentration of chitosan, but also by the kind and concentration of glycerophosphate. The properties and the three-dimensional networks of the hydrogel offer them wide applications in biomedical field including local drug delivery and tissue engineering.
authors.affiliation: Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, 263 Kaiyuan Road, Luoyang, 471023, PR China. Electronic address: hyzhou@haust.edu.cn.
authors.forename: Hui Yun
authors.initials: HY
authors.lastname: Zhou
authors.affiliation: Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, 263 Kaiyuan Road, Luoyang, 471023, PR China; Liaoning Haisco Pharmaceutical Co., Ltd., PR China.
authors.forename: Ling Juan
authors.initials: LJ
authors.lastname: Jiang
authors.affiliation: Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, 263 Kaiyuan Road, Luoyang, 471023, PR China.
authors.forename: Pei Pei
authors.initials: PP
authors.lastname: Cao
authors.affiliation: Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, 263 Kaiyuan Road, Luoyang, 471023, PR China.
authors.forename: Jun Bo
authors.initials: JB
authors.lastname: Li
authors.affiliation: College of Marine Life Science, Ocean University of China, 5 Yushan Road, Qingdao, 266003, PR China. Electronic address: xgchen@ouc.edu.cn.
authors.forename: Xi Guang
authors.initials: XG
authors.lastname: Chen
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D005994:Glycerophosphates / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D013696:Temperature; D023822:Tissue Engineering
chemical_list: D005994:Glycerophosphates; D020100:Hydrogels; D048271:Chitosan
keywords: Chitosan; Chitosan (PubChem CID: 71853); Drug delivery; Thermosensitive hydrogel; Tissue engineering; acetic acid (PubChem CID: 176); lactic acid (PubChem CID: 612); α-glycerophosphate (PubChem CID: 14754); αβ-Glycerophosphate; β-Glycerophosphate; β-glycerophosphate (PubChem CID: 6101544)