title: Glycol chitosan-based fluorescent theranostic nanoagents for cancer therapy.
abstract: Theranostics is an integrated nanosystem that combines therapeutics with diagnostics in attempt to develop new personalized treatments with enhanced therapeutic efficacy and safety. As a promising therapeutic paradigm with cutting-edge technologies, theranostic agents are able to simultaneously deliver therapeutic drugs and diagnostic imaging agents and also monitor the response to therapy. Polymeric nanosystems have been intensively explored for biomedical applications to diagnose and treat various cancers. In recent years, glycol chitosan-based nanoagents have been developed as dual-purpose materials for simultaneous diagnosis and therapy. They have shown great potential in cancer therapies, such as chemotherapeutics and nucleic acid and photodynamic therapies. In this review, we summarize the recent progress and potential applications of glycol chitosan-based fluorescent theranostic nanoagents for cancer treatments and discuss their possible underlying mechanisms.
authors.affiliation: Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Korea. jkrhee@kbsi.re.kr.
authors.forename: Jin-Kyu
authors.initials: JK
authors.lastname: Rhee
authors.affiliation: Division of Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea. okpark81@kbsi.re.kr.
authors.forename: Ok Kyu
authors.initials: OK
authors.lastname: Park
authors.affiliation: Biomedical Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea. fleur0903@hanmail.net.
authors.forename: Aeju
authors.initials: A
authors.lastname: Lee
authors.affiliation: Institute of Cell & Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. yangdh@catholic.ac.kr.
authors.forename: Dae Hyeok
authors.initials: DH
authors.lastname: Yang
authors.affiliation: Division of Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea. kspark1223@hanmail.net.
authors.forename: Kyeongsoon
authors.initials: K
authors.lastname: Park
mesh_terms: D000818:Animals; D048271:Chitosan / Q000494:pharmacology* / Q000627:therapeutic use*; D003952:Diagnostic Imaging / Q000379:methods; D005456:Fluorescent Dyes / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D005456:Fluorescent Dyes; C118638:glycol-chitosan; D048271:Chitosan