title: Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population.
abstract: Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model. We did not find a significant association between miR-146a polymorphism and prostrate-specific antigen failure in the Chinese population [HR (95%CI): 0.83 (0.30-2.32) for CC vs GG/GC]. However, high Gleason score (over 8) was associated with increased biochemical recurrence and poorer PSA-free survival. This study was limited by the length of follow-up. Future studies with longer follow-up would allow evaluation of more direct metrics, such as disease-specific survival, metastasis-free survival, and overall survival.
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Urology, The First People's Hospital of Suqian, Suqian, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: Department of Urology, 2nd Affliated Hospital of Nantong University, Nantong, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China.
authors.forename: N
authors.initials: N
authors.lastname: Tong
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Chen
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Zhang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: G Z
authors.initials: GZ
authors.lastname: Sha
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: W D
authors.initials: WD
authors.lastname: Zhu
authors.affiliation: Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: L X
authors.initials: LX
authors.lastname: Hua
authors.affiliation: Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China njxb1982@126.com.
authors.forename: B
authors.initials: B
authors.lastname: Xu
mesh_terms: D000368:Aged; D002681:China; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy / Q000706:statistics & numerical data*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D012008:Recurrence; D012307:Risk Factors
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D017430:Prostate-Specific Antigen