title: Genetic tuning of avian influenza A (H7N9) virus promotes viral fitness within different species.
abstract: Since their emergence in eastern China, novel influenza A (H7N9) viruses have been continuously circulating in poultry and causing human infections and death. We have proposed a "genetic tuning" mechanism for the genesis and evolution of the novel H7N9 virus during interspecies transmission.
authors.affiliation: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China. Electronic address: yshu@cnic.org.cn.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
mesh_terms: D000818:Animals; D001717:Birds; D019143:Evolution, Molecular; D056084:Genetic Fitness; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D005585:Influenza in Birds / Q000635:transmission / Q000821:virology*; D007251:Influenza, Human / Q000635:transmission* / Q000821:virology*; D015047:Zoonoses / Q000635:transmission
keywords: Avian influenza A (H7N9) virus; Genetic tuning; Potential hosts