title: [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model].
abstract: The present study aimed to investigate the effect and the mechanisms of Bu-zhong-yi-qi-tang (BZYQ) on Spleen-Qi deficiency rat's model using nuclear magnetic resonance (NMR) metabolomics and multivariate statistical analysis methods. The rat Spleen-Qi deficiency model was established as follows: oral administration of Radix Rhei extract, loaded swimming and starvation for 24 h. The body weight and motor behavior of the rats were measured and recorded once a week. BZYQ could significantly improve body weight and behavioral of Spleen-Qi deficiency model rats compared with the model group (P < 0.05, 0.01). After drug administration, the changes in the levels of endogenous metabolites in the spleen including decreasing lactate, taurine and hypoxanthine, increasing glutamate and scyllo-inositol compared with the model group. The metabolomics approach is an effective tool for the investigation of the pharmacologic mechanism of BZYQ and it is helpful to further research.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Huan
authors.initials: H
authors.lastname: Xiang
authors.forename: Jie
authors.initials: J
authors.lastname: Xing
authors.forename: Jun-Sheng
authors.initials: JS
authors.lastname: Tian
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Qin
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D055432:Metabolomics; D066244:Proton Magnetic Resonance Spectroscopy; D019413:Qi; D051381:Rats; D013154:Spleen
chemical_list: D004365:Drugs, Chinese Herbal; C402943:bu-zhong-yi-qi-tang