title: Catalytic enantioselective synthesis of quaternary carbon stereocentres.
abstract: Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoisomers of this important structural motif. Here we discuss the many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.
authors.forename: Kyle W
authors.initials: KW
authors.lastname: Quasdorf
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.
authors.forename: Larry E
authors.initials: LE
authors.lastname: Overman
mesh_terms: D016573:Agrochemicals / Q000138:chemical synthesis / Q000737:chemistry; D000478:Alkylation; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003348:Cortisone / Q000737:chemistry; D003500:Cyclization; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D009020:Morphine / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D016573:Agrochemicals; D001688:Biological Products; D008670:Metals; D009930:Organic Chemicals; D004364:Pharmaceutical Preparations; D013729:Terpenes; D010165:Palladium; D002244:Carbon; D009020:Morphine; D003348:Cortisone