title: Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.
abstract: A gradually expanding body of literature suggests that Thyroid Hormone (TH) and Thyroid Hormone Receptors (TRs) play a contributing role in pancreatic and islet cell development, maturation, and function. Studies using a variety of model systems capable of exploiting species-specific developmental paradigms have revealed the contribution of TH to cellular differentiation, lineage decisions, and endocrine cell specification. Moreover,in vitroandin vivoevidence suggests that TH is involved in islet β cell proliferation and maturation; however, the signaling pathway(s) connected with this function of TH/TR are not well understood. The purpose of this review is to discuss the current literature that has defined the effects of TH and TRs on pancreatic and islet cell development and function, describe the impact of hyper- and hypothyroidism on whole body metabolism, and highlight future and potential applications of TH in novel therapeutic strategies for diabetes.
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, USA ; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, USA.
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Mastracci
authors.affiliation: Department of Medicine, Indiana University School of Medicine, USA ; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, USA ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA ; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, USA.
authors.forename: Carmella
authors.initials: C
authors.lastname: Evans-Molina
keywords: Insulin secretion; Pancreatic islet; Thyroid hormone; Thyroid hormone receptor; β cell