title: Present state of microchip electrophoresis: state of the art and routine applications.
abstract: Microchip electrophoresis (MCE) was one of the earliest applications of the micro-total analysis system (μ-TAS) concept, whose aim is to reduce analysis time and reagent and sample consumption while increasing throughput and portability by miniaturizing analytical laboratory procedures onto a microfluidic chip. More than two decades on, electrophoresis remains the most common separation technique used in microfluidic applications. MCE-based instruments have had some commercial success and have found application in many disciplines. This review will consider the present state of MCE including recent advances in technology and both novel and routine applications in the laboratory. We will also attempt to assess the impact of MCE in the scientific community and its prospects for the future.
authors.affiliation: Korea Institute of Science and Technology - Europe GmbH, Saarbrücken, Germany.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Castro
authors.affiliation: Korea Institute of Science and Technology - Europe GmbH, Saarbrücken, Germany. Electronic address: manz@kist-europe.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Manz
mesh_terms: D046209:Electrophoresis, Microchip / Q000592:standards / Q000639:trends*; D006801:Humans; D044085:Microfluidics; D020411:Oligonucleotide Array Sequence Analysis
keywords: Electrophoresis; Microfluidics