title: One-pot synthesis of hollongdione from dipterocarpol.
abstract: A one-pot synthesis of a hybrid triterpenoid-steroid molecule, hollongdione (22,23,24,25,26,27-hexanordammar-3,20-dion), was achieved in a yield of 89%, based on the selective dehydration of dipterocarpol following ozonolysis. The structure of hollongdione was confirmed by X-ray analysis for the first time. Dammar-20(22),24(25)-dien inhibited the growth of Mycobacterium tuberculosis (strain H37Rv) in vitro with a MIC of 50 μg/mL.
authors.forename: Irina E
authors.initials: IE
authors.lastname: Smirnova
authors.forename: Oxana B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: Do Thi Thu
authors.initials: do TT
authors.lastname: Huong
authors.forename: El'za M
authors.initials: EM
authors.lastname: Minnibaeva
authors.forename: Alexandr N
authors.initials: AN
authors.lastname: Lobov
authors.forename: Kiryll Yu
authors.initials: KY
authors.lastname: Suponitsky
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013256:Steroids / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D013256:Steroids; D014315:Triterpenes