title: Cardiovascular transcriptomics and epigenomics using next-generation sequencing: challenges, progress, and opportunities.
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: Po-Yen
authors.initials: PY
authors.lastname: Wu
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: Raghu
authors.initials: R
authors.lastname: Chandramohan
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: John H
authors.initials: JH
authors.lastname: Phan
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: William T
authors.initials: WT
authors.lastname: Mahle
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.).
authors.forename: Kevin O
authors.initials: KO
authors.lastname: Maher
authors.affiliation: From the School of Electrical and Computer Engineering (P.-Y.W.), School of Biology (R.C.), Georgia Institute of Technology, Atlanta, GA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA (J.H.P.); The Wallace H. Coulter Department of Biomedical Engineering, School of Electrical and Computer Engineering, Winship Cancer Institute, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology and Emory University, Atlanta, GA (M.D.W.); Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (W.T.M., K.O.M.); The Children's Hospital of Philadelphia, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.W.G.). maywang@bme.gatech.edu.
authors.forename: May D
authors.initials: MD
authors.lastname: Wang
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism*; D047369:Chromatin Immunoprecipitation; D019295:Computational Biology / Q000379:methods; D057890:Epigenomics / Q000379:methods* / Q000639:trends*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods* / Q000639:trends*; D006801:Humans; D017423:Sequence Analysis, RNA; D059467:Transcriptome
keywords: biomarkers; chromatin immunoprecipitation; computational biology; epigenomics; gene expression profiling; high-throughput nucleotide sequencing; transcriptome