title: Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways.
abstract: Hydrogen sulfide (H2S) is an endogenously produced gas that represents a novel third gaseous signaling molecule, neurotransmitter and cytoprotectant. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), 3-mercaptopyruvate sulfur transferase with cysteine aminotransferase (3-MST/CAT) and 3-mercaptopyruvate sulfur transferase with d-amino acid oxidase (3-MST/DAO) pathways are involved in the generation of endogenous H2S despite the ubiquitous or restricted distribution of those enzymes. CBS, 3-MST/CAT and 3-MST/DAO can be found in the brain, while CSE is widely located in other organs. There also exist up-taking or recycling and scavenging mechanisms in H2S metabolism to maintain its persistence for physiological function. In recent years, investigating the role that H2S plays in the central nervous system and cardiovascular system has always been a hotspot. To date, effects of H2S are at least partially verified in multiple animal models or neuron cell lines of Alzheimer's disease, Parkinson's disease, cerebral ischemia, major depression disorders and febrile seizure, although subsequent studies are still badly needed. This article presents an overview of current knowledge of H2S focusing on its neuroprotective effects and corresponding signaling pathways, together with connections to potential therapeutic strategies in the clinic.
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Chen
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Niu
authors.forename: Wei-Zheng
authors.initials: WZ
authors.lastname: Jiang
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: Tang
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.forename: Qi-Ming
authors.initials: QM
authors.lastname: Xia
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Tang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism* / Q000494:pharmacology; D007473:Ion Channels / Q000378:metabolism; D009422:Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015398:Signal Transduction
chemical_list: D007473:Ion Channels; D018696:Neuroprotective Agents; D006862:Hydrogen Sulfide