title: Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study.
abstract: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.
authors.affiliation: Department of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
authors.forename: Marinka
authors.initials: M
authors.lastname: Mravak-Stipetić
authors.affiliation: Department of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
authors.forename: Božana
authors.initials: B
authors.lastname: Lončar-Brzak
authors.affiliation: Department of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
authors.forename: Iva
authors.initials: I
authors.lastname: Bakale-Hodak
authors.affiliation: Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
authors.forename: Ivan
authors.identifier: 0000-0002-5753-8528
authors.initials: I
authors.lastname: Sabol
authors.affiliation: Department of Pediatric Dentistry, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.affiliation: School of Medicine, Institute of Pathology, University of Zagreb, 10000 Zagreb, Croatia.
authors.forename: Martina
authors.initials: M
authors.lastname: Majstorović
authors.affiliation: Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Grce
mesh_terms: D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*