title: Genetic association between p73 G4C14-A4T14 polymorphism and risk of squamous cell carcinoma.
abstract: This study is to evaluate the association between p73 G4C14-A4T14 polymorphism and squamous cell carcinoma (SCC) risk in diverse populations. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine databases for all articles on the association between p73 G4C14-A4T14 polymorphism and SCC risk through March 2014. We performed a comprehensive meta-analysis of six case-control studies that included 1,758 SCC cases and 2,970 case-free controls. All analyses were performed using STATA 11.0, using two-sided P values. Overall, this meta-analysis showed that the p73 G4C14-A4T14 polymorphism was associated with a significantly increased risk of SCC in three genetic models. However, after excluding one study deviating from Hardy-Weinberg equilibrium, the results then demonstrated that the p73 G4C14-A4T14 polymorphism was only associated with elevated risk of cervical squamous cell carcinoma (for AT/GC vs GC/GC: OR 1.51, 95 % CI 1.14-2.00, P heterogeneity = 0.996; for AT/AT+AT/GC vs GC/GC: OR 1.42, 95 % CI 1.08-1.87, P heterogeneity = 0.994) in subgroup analysis by tumor sites. No publication bias was found in the present study. This meta-analysis suggests that the p73 G4C14-A4T14 polymorphism is associated with an increased risk of cervical squamous cell carcinoma. Further large and well-designed studies are needed to confirm this association.
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, NO. 28, Fuxing Road, Beijing, 100853, China.|Center for Disease Control and Prevention, Chengdu Military Command, Chengdu, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Xia
authors.affiliation: Center for Disease Control and Prevention, Chengdu Military Command, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of General Surgery, Clinical Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, NO. 28, Fuxing Road, Beijing, 100853, China.
authors.forename: Zigang
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, NO. 28, Fuxing Road, Beijing, 100853, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, NO. 28, Fuxing Road, Beijing, 100853, China. lihengjin1@126.com.
authors.forename: Hengjin
authors.initials: H
authors.lastname: Li
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
keywords: Meta-analysis; P73; Polymorphism; Squamous cell carcinoma