title: Nephroprotection of plantamajoside in rats treated with cadmium.
abstract: Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Jung
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea; Food Analysis Center, Korea Food Research Institute, 516, Baekhyeon, Bundang, Seongnam, Gyeonggi 463-746, Republic of Korea.
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Seo
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Chung-Oui
authors.initials: CO
authors.lastname: Hong
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Sung-Yong
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: kwangwon@korea.ac.kr.
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Lee
mesh_terms: D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D002396:Catechols / Q000494:pharmacology / Q000627:therapeutic use*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004785:Environmental Pollutants / Q000493:pharmacokinetics / Q000633:toxicity*; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002104:Cadmium; D002374:Catalase; D002396:Catechols; D015815:Cell Adhesion Molecules; D004785:Environmental Pollutants; D005960:Glucosides; D005978:Glutathione; D019803:Glutathione Disulfide; D005979:Glutathione Peroxidase; D020011:Protective Agents; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; C110936:Havcr1 protein, rat; C421173:plantamajoside
keywords: Cadmium; Kidney injury molecule-1; Lipid peroxidation; Nephrotoxicity; Oxidative stress; Plantamajoside