title: Chemokine receptor V Δ32 deletion in multiple sclerosis patients in Csongrád County in Hungary and the North-Bácska region in Serbia.
abstract: The roles of chemokine receptor V (CCR5) and its polymorphism, rs333 in multiple sclerosis (MS) are controversial. We investigated the receptor and its deletion in a large MS (428) and a numerous control (831) population in Csongrád County (Hungary) and North-Bácska (Serbia). Taqman probes firstly were used for the allele discrimination. There was no significant difference in genotype (OR=1.092, 95% CI=0.807-1.478, p=0.568 for wt/wt (wt=wild type allele) vs wt/Δ32, Δ32/Δ32 (Δ32=Δ32 base pair deletion allele)) or allele frequency (OR=0.914, 95% CI=0.692-1.207, p=0.525). Neither the deletion nor the wt allele affected the Expanded Disability Status Scale score or the age at onset. Our results indicate no association between the CCR5 Δ32 allele and MS.
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Nóra
authors.initials: N
authors.lastname: Török
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Kinga
authors.initials: K
authors.lastname: Molnár
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Füvesi
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Mária
authors.initials: M
authors.lastname: Karácsony
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Viktória
authors.initials: V
authors.lastname: Zsiros
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Annamária
authors.initials: A
authors.lastname: Fejes-Szabó
authors.affiliation: Faculty of Public Health, University of Debrecen, Kassai u 26, H-4012 Debrecen, Hungary.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Fiatal
authors.affiliation: Faculty of Public Health, University of Debrecen, Kassai u 26, H-4012 Debrecen, Hungary.
authors.forename: Róza
authors.initials: R
authors.lastname: Ádány
authors.affiliation: Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6725 Szeged, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Somogyvári
authors.affiliation: Department of Neurology, Public Hospital of Subotica, 3 Izvorska, Subotica, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Stojiljković
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary; MTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
authors.affiliation: Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary. Electronic address: bencsik.krisztina@med.u-szeged.hu.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Bencsik
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology; D017384:Sequence Deletion; D055771:Serbia
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5
keywords: CCR5 Δ32 allele; Genetics; Multiple sclerosis