title: Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high-fat diet-streptozotocin-induced diabetic rats.
abstract: BACKGROUND
  Diabetes is often connected with significant morbidity, mortality and also has a pivotal role in the development of cardiovascular diseases. Diet intervention, particularly naturaceutical antioxidants have anti-diabetic potential and avert oxidative damage linked with diabetic pathogenesis. The present study investigated the effects of diosgenin, a saponin from fenugreek, on the changes in lipid profile in plasma, liver, heart and brain in high-fat diet-streptozotocin (HFD-STZ)-induced diabetic rats. Diosgenin was administered to HFD-STZ induced diabetic rats by orally at 60 mg kg(-1) body weight for 30 days to assess its effects on body weight gain, glucose, insulin, insulin resistance and cholesterol, triglycerides, free fatty acids and phospholipids in plasma, liver, heart and brain.
  
  
  RESULTS
  The levels of body weight, glucose, insulin, insulin resistance, cholesterol, triglycerides, free fatty acids, phospholipids, VLDL-C and LDL-C were increased significantly (P < 0.05) whereas HDL-C level decreased in the HFD/STZ diabetic rats. Administration of diosgenin to HFD-STZ diabetic rats caused a decrease in body weight gain, blood glucose, insulin, insulin resistance and also it modulated lipid profile in plasma and tissues.
  
  
  CONCLUSIONS
  The traditional plant fenugreek and its constituents mediate its anti-diabetic potential through mitigating hyperglycaemic status, altering insulin resistance by alleviating metabolic dysregulation of lipid profile in both plasma and tissues.
authors.affiliation: Department of Biochemistry, Animal physiology & Biochemistry Laboratory, Sri Venkateswara University, Tirupati, 517502, India.
authors.forename: Parim Brahma
authors.initials: PB
authors.lastname: Naidu
authors.affiliation: Department of Biotechnology, K.S. Rangasamy College of Technology, Thokkavadi, Tiruchengode, Tamil Nadu, India.
authors.forename: Ponnusamy
authors.initials: P
authors.lastname: Ponmurugan
authors.affiliation: Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India.
authors.forename: Mustapha Sabana
authors.initials: MS
authors.lastname: Begum
authors.affiliation: Department of Biochemistry, St. Josephs College, Tiruchirappalli, Tamil Nadu, India.
authors.forename: Karthick
authors.initials: K
authors.lastname: Mohan
authors.affiliation: Department of Biochemistry, Animal physiology & Biochemistry Laboratory, Sri Venkateswara University, Tirupati, 517502, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Meriga
authors.affiliation: National Center for Laboratory Animal Sciences, National Institute of Nutrition (ICMR) New Delhi, India.
authors.forename: Ramavat
authors.initials: R
authors.lastname: RavindarNaik
authors.affiliation: Department of Biochemistry, Centre for Biological Science, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India.
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Saravanan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects; D004144:Diosgenin / Q000494:pharmacology / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D029910:Trigonella / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004041:Dietary Fats; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D004144:Diosgenin
keywords: diabetes; diosgenin; lipids; streptozotocin