title: NF GEMMs already! The power and promise of mouse tumor models.
abstract: Plexiform neurofibromas are one of the most common tumors encountered in individuals with the neurofibromatosis type I (NF1) cancer predisposition syndrome. In this issue of Cancer Cell, Chen and colleagues define the cell of origin for murine Nf1 plexiform neurofibroma and leverage this finding to develop a platform for preclinical drug evaluation.
authors.affiliation: Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis MO 63110, USA. Electronic address: gutmannd@neuro.wustl.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Gutmann
mesh_terms: D000818:Animals; D005260:Female; D018318:Neurofibroma, Plexiform / Q000473:pathology*; D025542:Neurofibromin 1 / Q000235:genetics*; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology*
chemical_list: D025542:Neurofibromin 1