title: Beyond H₂: exploiting 2-hydroxypyridine as a design element from [Fe]-hydrogenase for energy-relevant catalysis.
abstract: The unique primary and secondary coordination environments surrounding the active site of hydrogenase enzymes play a crucial role in H2 activation and transfer reactions. [Fe]-hydrogenase contains a 2-hydroxypyridine ligand motif, and many researchers have incorporated this design element into synthetic catalysts. Transition metal complexes supported by 2-hydroxypyridine scaffolds are catalysts for chemical conversion schemes relevant to alternative energy applications and, in addition to hydrogenase-type reactivity, find new uses in other chemical domains. In this review, the current status of 2-hydroxypyridine-derived catalysts is described with an emphasis on design features that lead to lower energy catalytic pathways.
authors.affiliation: Department of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, MI 48109, United States.
authors.forename: Cameron M
authors.initials: CM
authors.lastname: Moore
authors.affiliation: Department of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, MI 48109, United States.
authors.forename: Eric W
authors.initials: EW
authors.lastname: Dahl
authors.affiliation: Department of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, MI 48109, United States. Electronic address: nszym@umich.edu.
authors.forename: Nathaniel K
authors.initials: NK
authors.lastname: Szymczak
mesh_terms: D002384:Catalysis; D015195:Drug Design; D006864:Hydrogenase / Q000737:chemistry* / Q000378:metabolism; D007506:Iron-Sulfur Proteins / Q000737:chemistry* / Q000378:metabolism; D011728:Pyridones / Q000737:chemistry*; D059205:Renewable Energy; D014867:Water / Q000737:chemistry
chemical_list: D007506:Iron-Sulfur Proteins; D011728:Pyridones; D014867:Water; C017679:2-hydroxypyridine; C118830:iron hydrogenase; D006864:Hydrogenase