title: Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia.
abstract: BACKGROUND
  Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors.
  
  
  METHODS
  The MDR1 gene polymorphisms rs1045642, rs2032582 and MTHFR gene polymorphisms rs1801131 and rs1801133 were genotyped in 68 ALL patients in remission and 102 age and gender matched controls; parental DNA samples were also available for 42 probands.
  
  
  RESULTS
  No case control association was found between analyzed polymorphisms and a risk of childhood ALL development. Linkage disequilibrium was not observed in a family-based association study either. Only marginal association was observed between genetic marker rs2032582A and later disease onset (p=0.04).
  
  
  CONCLUSIONS
  Our data suggest that late age of ALL onset could be triggered by mild effect common alleles.
authors.affiliation: Riga Stradins University, Latvia E-mail : madara.kreile@rsu.lv.
authors.forename: Madara
authors.initials: M
authors.lastname: Kreile
authors.forename: Dmitrijs
authors.initials: D
authors.lastname: Rots
authors.forename: Linda
authors.initials: L
authors.lastname: Piekuse
authors.forename: Elizabete
authors.initials: E
authors.lastname: Cebura
authors.forename: Marika
authors.initials: M
authors.lastname: Grutupa
authors.forename: Zhanna
authors.initials: Z
authors.lastname: Kovalova
authors.forename: Baiba
authors.initials: B
authors.lastname: Lace
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)