title: Antifungal innate immunity: recognition and inflammatory networks.
abstract: A large variety of fungi are present in the environment, among which a proportion colonizes the human body, usually without causing any harm. However, depending on the host immune status, commensals can become opportunistic pathogens that induce diseases ranging from superficial non-harmful infection to life-threatening systemic disease. The interplay between the host and the fungal commensal flora is being orchestrated by an efficient recognition of the microorganisms, which in turn ensures a proper balance between tolerance of the normal fungal flora and induction of immune defense mechanisms when invasion occurs. Pattern recognition receptors (PRRs) play a significant role in maintaining this balance due to their capacity to sense fungi and induce host responses such as the induction of proinflammatory cytokines involved in the activation of innate and adaptive immune responses. In the present review, we will discuss the most recent findings regarding the recognition of Candida albicans and Aspergillus fumigatus and the different types of immune cells that play a role in antifungal host defense.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Centre and Radboud Center for Infectious Diseases (RCI), Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
authors.forename: Katharina L
authors.initials: KL
authors.lastname: Becker
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Ifrim
authors.forename: Jessica
authors.initials: J
authors.lastname: Quintin
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Frank L
authors.initials: FL
authors.lastname: van de Veerdonk
mesh_terms: D000818:Animals; D005658:Fungi / Q000276:immunology* / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate; D009181:Mycoses / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition