title: Acanthamoeba polyphaga mimivirus prevents amoebal encystment-mediating serine proteinase expression and circumvents cell encystment.
abstract: Acanthamoeba is a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus, Acanthamoeba polyphaga mimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Boratto
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Jonas Dutra
authors.initials: JD
authors.lastname: Albarnaz
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Gabriel Magno de Freitas
authors.initials: GM
authors.lastname: Almeida
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Lucas
authors.initials: L
authors.lastname: Botelho
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Micologia, Belo Horizonte, MG, Brazil.
authors.forename: Alide Caroline Lima
authors.initials: AC
authors.lastname: Fontes
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Belo Horizonte, MG, Brazil.
authors.forename: Adriana Oliveira
authors.initials: AO
authors.lastname: Costa
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Micologia, Belo Horizonte, MG, Brazil.
authors.forename: Daniel de Assis
authors.initials: Dde A
authors.lastname: Santos
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Cláudio Antônio
authors.initials: CA
authors.lastname: Bonjardim
authors.affiliation: URMITE CNRS UMR 6236-IRD 3R198, Aix Marseille Universite, Marseille, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: La Scola
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
authors.forename: Erna Geessien
authors.initials: EG
authors.lastname: Kroon
authors.affiliation: Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil jonatas.abrahao@gmail.com.
authors.forename: Jônatas Santos
authors.initials: JS
authors.lastname: Abrahão
mesh_terms: D000048:Acanthamoeba / Q000201:enzymology* / Q000254:growth & development / Q000821:virology*; D006790:Host-Parasite Interactions; D056686:Mimiviridae / Q000254:growth & development*; D057057:Serine Proteases / Q000096:biosynthesis*; D033761:Spores, Protozoan / Q000254:growth & development*
chemical_list: D057057:Serine Proteases