title: Evaluation of corneal topography and biomechanical parameters after use of systemic isotretinoin in acne vulgaris.
abstract: Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated. All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk (Sirius), ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline, in the 1st, 3rd, and 6th months of treatment, and 6 months after isotretinoin discontinuation. Results. The thinnest corneal thickness measured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was no significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis and corneal resistance factor) throughout the study. Average simulated keratometry and surface asymmetry index increased significantly only in the first month of treatment according to the baseline. All changes disappeared 6 months after the end of treatment. Conclusion. Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic isotretinoin treatment and the changes were reversible after discontinuation. No statistical important biomechanical differences were found to be induced by isotretinoin.
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Onur
authors.identifier: 0000-0003-4447-2635
authors.initials: O
authors.lastname: Olcucu
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Agca
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Alagoz
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Ali
authors.identifier: 0000-0002-4637-2825
authors.initials: A
authors.lastname: Demircan
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoğlu, 34420 Istanbul, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Basci
authors.affiliation: Department of Ophthalmology, Göztepe Education and Research Hospital, Istanbul Medeniyet University, Dr. Erkin Caddesi, Kadıkoy, 34732 Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
authors.affiliation: Department of Dermatology, Cerrahpaşa Faculty of Medicine, Istanbul University, Kocamustafapaşa Caddesi No. 53, Cerrahpaşa, Fatih, 34098 Istanbul, Turkey.
authors.forename: Zekayi
authors.identifier: 0000-0003-0809-1624
authors.initials: Z
authors.lastname: Kutlubay