title: Activity of coagulation factor XI in patients with spontaneous miscarriage: the presence of risk alleles.
abstract: The aim of this study was to compare the activity of coagulation factor XI (FXI) between patients with spontaneous miscarriage versus control group with no history of miscarriage and thrombosis, and then we evaluated the occurrence of risk alleles in the relation to miscarriage. FXI activity was determined using a coagulometer (Sysmex, CA 1500, Japan). Single nucleotide polymorphisms (SNPs) of F11 and CYP4V2 genes were evaluated. We examined 55 patients versus 31 control subjects. We found significantly higher activity of FXI (p = 0.04) in patients versus control subjects. The occurrence of two SNPs (rs2289252 and rs2036914) of the F11 gene and SNP (rs13146272) of CYP4V2 gene was not significantly different between both groups. Increased activity of FXI may be a potential risk factor for miscarriage. High activity of FXI diagnosed in women with history of miscarriage is not probably caused by the presence of studied SNPs.
authors.affiliation: a Department of Haematology and Transfusiology , National Center of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Sokol
authors.affiliation: b Department of Obstetrics and Gynaecology , Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia.
authors.forename: K
authors.initials: K
authors.lastname: Biringer
authors.affiliation: c Department of Biochemistry , Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Skerenova
authors.affiliation: a Department of Haematology and Transfusiology , National Center of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Stasko
authors.affiliation: a Department of Haematology and Transfusiology , National Center of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia.
authors.forename: P
authors.initials: P
authors.lastname: Kubisz
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000483:Alleles; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D000072470:Cytochrome P450 Family 4; D005172:Factor XI / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D005172:Factor XI; D003577:Cytochrome P-450 Enzyme System; C505357:CYP4V2 protein, human; D000072470:Cytochrome P450 Family 4
keywords: Alleles; factor XI; single nucleotide polymorphism; spontaneous miscarriage; thrombophilia