title: Complete genome sequence of the actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) consisting of a linear chromosome and one linear plasmid.
abstract: Here we report the complete and finished genome sequence of Streptomyces glaucescens GLA.O (DSM 40922), a natural producer of the alpha-glucosidase inhibitor acarbose, which is used in the treatment of type-2 diabetes mellitus. The genome of S. glaucescens GLA.O consists of two replicons, the chromosome with a size of 7,453,200bp and a G+C content of 73.0% as well as a plasmid named pSglau1 with a size of 170,574bp and a G+C content of 69.06%.
authors.affiliation: Senior Research Group Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany; Microbial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Ortseifen
authors.affiliation: Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Winkler
authors.affiliation: Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Albersmeier
authors.affiliation: Senior Research Group Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Sergej
authors.initials: S
authors.lastname: Wendler
authors.affiliation: Senior Research Group Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Alfred
authors.initials: A
authors.lastname: Pühler
authors.affiliation: Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany; Microbial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Kalinowski
authors.affiliation: Senior Research Group Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany; Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany; Microbial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany. Electronic address: christian.rueckert@cebitec.uni-bielefeld.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Rückert
mesh_terms: D001482:Base Composition / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D013302:Streptomyces / Q000235:genetics*
keywords: 5′-hydroxystreptomycin; Acarbose production; Genome sequence; Streptomyces; Tetracenomycin C