title: A community assessment of privacy preserving techniques for human genomes.
abstract: To answer the need for the rigorous protection of biomedical data, we organized the Critical Assessment of Data Privacy and Protection initiative as a community effort to evaluate privacy-preserving dissemination techniques for biomedical data. We focused on the challenge of sharing aggregate human genomic data (e.g., allele frequencies) in a way that preserves the privacy of the data donors, without undermining the utility of genome-wide association studies (GWAS) or impeding their dissemination. Specifically, we designed two problems for disseminating the raw data and the analysis outcome, respectively, based on publicly available data from HapMap and from the Personal Genome Project. A total of six teams participated in the challenges. The final results were presented at a workshop of the iDASH (integrating Data for Analysis, 'anonymization,' and SHaring) National Center for Biomedical Computing. We report the results of the challenge and our findings about the current genome privacy protection techniques.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Jiang
authors.forename: Yongan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Bradley
authors.initials: B
authors.lastname: Malin
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Lucila
authors.initials: L
authors.lastname: Ohno-Machado
authors.forename: Haixu
authors.initials: H
authors.lastname: Tang
mesh_terms: D030661:Genetic Privacy / Q000592:standards*; D055106:Genome-Wide Association Study / Q000592:standards*; D006801:Humans; D033181:Information Dissemination