title: Rheumatoid arthritis and the alpha-chemokine IP-10.
abstract: Interferon(IFN)-gamma-induced protein 10 (IP-10) and its receptor, CXCR3, appear to contribute to the pathogenesis of rheumatoid arthritis (RA). IP-10 has been detected in sera, synovial fluid (SF), and synovial tissue in RA patients. IP-10 is mainly expressed by infiltrating macrophage-like cells and fibroblast-like synoviocytes in RA synovium. The elevated expression of CXCR3 on T cells from SF has been associated with high levels of IFN-gamma, which suggest a preferential Th1 phenotype. A human phase II clinical trial using an anti-IP-10 monoclonal antibody (MDX-1100) for RA patients who had an inadequate response to methotrexate treatment has shown that blocking IP-10 significantly increased response rate compared to the placebo group, suggesting a possible therapeutic use in humans.
authors.affiliation: Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Domenicantonio
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D054367:Receptors, CXCR3 / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; C574193:MDX-1100; D054367:Receptors, CXCR3
keywords: CXCR3; IP-10; Rheumatoid arthritis