title: Eating behavior, weight problems and eating disorders in 101 long-term survivors of childhood-onset craniopharyngioma.
abstract: BACKGROUND
  As a result of hypothalamic involvement and/or treatment-related hypothalamic damage, up to 75% of childhood craniopharyngioma patients develop hypothalamic obesity.
  
  
  METHODS
  Eating behavior was analyzed in 101 survivors of childhood craniopharyngioma, recruited from 1980 to 2001 in the HIT-Endo multicenter study, and in 85 body mass index (BMI)-matched healthy controls using the Inventory for Eating Behavior and Weight Problems (IEG) and the Inventory for Eating Disorders (ESI).
  
  
  RESULTS
  Severely obese patients (BMI>8 SD; n=9) presented with pathological eating behavior, more weight problems, and eating disorders, as compared to obese (BMI 3-8 SD; n=44) and normal or overweight patients (BMI<3 SD; n=48). Craniopharyngioma patients with different degrees of obesity showed similar or even less pathological findings as compared to BMI-matched normal controls.
  
  
  CONCLUSIONS
  Severe obesity is associated with pathological eating behavior/disorders in craniopharyngioma patients. As these disorders are not disease-specific, risk factors for hypothalamic obesity should be the focus of further craniopharyngioma research.
authors.forename: Anika
authors.initials: A
authors.lastname: Hoffmann
authors.forename: Frank P
authors.initials: FP
authors.lastname: Postma
authors.forename: Anthe S
authors.initials: AS
authors.lastname: Sterkenburg
authors.forename: Ursel
authors.initials: U
authors.lastname: Gebhardt
authors.forename: Hermann L
authors.initials: HL
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D002648:Child; D003397:Craniopharyngioma / Q000150:complications / Q000453:epidemiology* / Q000523:psychology; D005247:Feeding Behavior / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D050177:Overweight / Q000453:epidemiology / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000523:psychology; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult