title: Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients.
abstract: Articular cartilage injury is the most common type of damage seen in clinical orthopedic practice. The matrix-induced autologous chondrocyte implant (MACI) was developed to repair articular cartilage with an advance on the autologous chondrocyte implant procedure. This study aimed to evaluate whether MACI is a safe and efficacious cartilage repair treatment for patients with knee cartilage lesions. The primary outcomes were the Knee Injury and Osteoarthritis Outcome Score (KOOS) domains and magnetic resonance imaging (MRI) results, compared between baseline and postoperative months 3, 6, 12, and 24. A total of 15 patients (20 knees), with an average age of 33.9 years, had a mean defect size of 4.01 cm(2). By 6-month follow-up, KOOS results demonstrated significant improvements in symptoms and knee-related quality of life. MRI showed significant improvements in four individual graft scoring parameters at 24 months postoperatively. At 24 months, 90% of MACI grafts had filled completely and 10% had good-to-excellent filling of the chondral defect. Most (95%) of the MACI grafts were isointense and 5% were slightly hyperintense. Histologic evaluation at 15 and 24 months showed predominantly hyaline cartilage in newly generated tissue. There were no postoperative complications in any patients and no adverse events related to the MACI operation. This 2-year study has confirmed that MACI is safe and effective with the advantages of a simple technique and significant clinical improvements. Further functional and mechanistic studies with longer follow-up are needed to validate the efficacy and safety of MACI in patients with articular cartilage injuries.
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of MRI Center, General Hospital of CAPF, Beijing, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Huiru
authors.initials: H
authors.lastname: Ji
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Minmin
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Orthopedics, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing.
authors.forename: Jianlei
authors.initials: J
authors.lastname: Hou
authors.affiliation: Center for Orthopedic Research, School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Minghao
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Center for Orthopedic Research, School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wood
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
authors.forename: Jiazhi
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA ; Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.affiliation: Medical Research Center, General Hospital of Chinese People's Armed Police Forces (CAPF), Beijing, People's Republic of China.
authors.forename: Aibing
authors.initials: A
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002358:Cartilage, Articular / Q000473:pathology* / Q000601:surgery*; D002681:China / Q000208:ethnology; D019902:Chondrocytes / Q000166:cytology / Q000473:pathology / Q000637:transplantation*; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000473:pathology* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D055815:Young Adult
keywords: KOOS; Knee Injury and Osteoarthritis Outcome Score; MRI; articular cartilage lesion; magnetic resonance imaging