title: Effects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat's choroid of eye.
abstract: OBJECTIVE
  To investigate the effect ofcurcumin on microvasculature changes in STZ-induced diabetic rat' choroid ofeye.
  
  
  METHODS
  Male rats were divided into three groups: control (C) Diabetic rats were induced by streptozotocin (STZ) (60 mg/kg BW) (DM) diabetic rats treated with curcumin (DMC) (200 mg/kg BW). After 8 weeks of experiments, microvasculature changes of rat's choroid were studied under vascular corrosion cast technique with scanning electron microscope (SEM).
  
  
  RESULTS
  There were pathology and destruction of choroid microvasculature of DM group that revealed reduced and shrunken sizes of large and small blood vessels, compared with control group; long posterior ciliary arteries (LPCAs) (C = 113.70 +/- 1.38, DM = 83.53 +/- 2.70, DMC = 109.64 +/- 3.41 microm), choroid arteries (C = 94.97 +/- 2.79, DM = 59.36 +/- 2.61, DMC = 80.31 +/- 3.73 microm), vortex veins (C = 74.11 +/- 3.24, DM = 46.71 +/- 2.56, DMC = 64.66 +/- 3.60 microm), and Choriocapillaris (choroidal capillaries) (C = 13.61 +/- 0.62, DM = 4.46 +/- 0.24, DMC = 9.96 +/- 0.70 microm), respectively. In DM group, LPCAs and Choroid arteries were tortuous and showed shrinkage. Vortex veins became narrow. Choriocapillaris showed the pathological characteristics of vascular lesions including of shrinkage, constriction, microaneurysm and blind ending. Fascinatingly, Choroid microvasculature of the eye in curcumin treated group developed into regenerate and repaired conditions with healthy and normal characteristics.
  
  
  CONCLUSIONS
  Efficiency of curcumin treatment beneficially repaired and regenerated the redevelopment of choroid's microvascular complications of eye in 8-week experiments. Potential treatment with curcumin in diabetes has demonstrated in a meaningful way the therapeutic consequences in the improvement and recovery of choroidal blood vessels in eye pathology ofdiabetic rats.
authors.forename: Wipapan
authors.initials: W
authors.lastname: Khimmaktong
authors.forename: Hattaya
authors.initials: H
authors.lastname: Petpiboolthai
authors.forename: Piyanee
authors.initials: P
authors.lastname: Sriya
authors.forename: Vipavee
authors.initials: V
authors.lastname: Anupunpisit
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D002196:Capillaries; D002829:Choroid / Q000098:blood supply* / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D055806:Microvessels; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin