title: Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer.
abstract: Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hayano
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujishiro
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Dushyant V
authors.initials: DV
authors.lastname: Sahani
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Asami
authors.initials: A
authors.lastname: Satoh
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Aoyagi
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Gaku
authors.initials: G
authors.lastname: Ohira
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Toru
authors.initials: T
authors.lastname: Tochigi
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
authors.affiliation: Koichi Hayano, Dushyant V Sahani, Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, United States.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D003287:Contrast Media; D006439:Hemodynamics; D006801:Humans; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D018579:Patient Selection; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D003287:Contrast Media
keywords: Angiogenesis; Antiangiogenic therapy; Chemoradiation therapy; Colorectal cancer; Computed tomography perfusion