title: Evidence unclear on whether Type I or II diabetes increases the risk of implant failure.
abstract: METHODS
  PubMed, Web of Science and the Cochrane Oral Health Group Trials Register, www.clinicaltrials.gov, www.centerwatch.com and www.clinicalconnection.com databases. Manual searches of a number of dental journals and the reference lists of identified studies were undertaken.
  
  
  METHODS
  Human clinical studies comparing implant failure rates in diabetic and non-diabetic patients were considered. Three reviewers independently selected studies.
  
  
  METHODS
  The definition of implant failure used was complete loss of the implant. Study quality was assessed using the Cochrane risk of bias approach. A narrative summary of the studies and meta-analysis are presented.
  
  
  RESULTS
  Fourteen studies were included (one randomised controlled trial, six controlled clinical trials and seven retrospective analysis); all 14 were considered to be at high risk of bias. Meta-analysis (14 studies) found no significant difference between diabetic and non-diabetic patients; risk ratio of 1.07 (95% CI = 0.80, 1.44)(p = 65). A meta-analysis of two studies found a statistically significant difference (mean difference =0.20, 95% CI = 0.08, 0.31 p = 001;) between diabetic and non-diabetic patients concerning marginal bone loss, favouring non-diabetic patients. Meta-analysis was not possible for postoperative infections.
  
  
  CONCLUSIONS
  The results of the present systematic review should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies. Within the limits of the existing investigations, the difference between the insertion of dental implants in non-diabetic and diabetic patients did not statistically affect the implant failure rates.
authors.affiliation: Department of Adult Oral Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK and Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
authors.forename: Dominic
authors.initials: D
authors.lastname: Hurst
mesh_terms: D015921:Dental Implants; D019232:Dental Restoration Failure; D048909:Diabetes Complications; D006801:Humans
chemical_list: D015921:Dental Implants