title: Subjective memory impairment and cholinergic transmission: a TMS study.
abstract: Subjective memory impairment (SMI) is being increasingly recognized as a preclinical phase of Alzheimer disease (AD). Short latency afferent inhibition (SAI) is helpful in demonstrating dysfunction of central cholinergic circuits, and was reported to be abnormal in patients with AD and amnestic multiple domain mild cognitive impairment. In this study, we found normal SAI in 20 subjects with SMI. SAI could be a useful biomarker for identifying, among individuals with memory complaints, those in whom cholinergic degeneration has occurred.
authors.affiliation: Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University and Center for Cognitive Neuroscience, Salzburg, Austria, raffaele.nardone@asbmeran-o.it.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Nardone
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Höller
authors.forename: Arne C
authors.initials: AC
authors.lastname: Bathke
authors.forename: Peter
authors.initials: P
authors.lastname: Höller
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Lochner
authors.forename: Frediano
authors.initials: F
authors.lastname: Tezzon
authors.forename: Eugen
authors.initials: E
authors.lastname: Trinka
authors.forename: Francesco
authors.initials: F
authors.lastname: Brigo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D059329:Cholinergic Neurons / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D010465:Perception; D062706:Prodromal Symptoms; D009435:Synaptic Transmission / Q000502:physiology; D050781:Transcranial Magnetic Stimulation