title: BMI variation increases recurrence risk in women with early-stage breast cancer.
abstract: OBJECTIVE
  The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown.
  
  
  METHODS
  The χ(2) test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences.
  
  
  RESULTS
  BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype.
  
  
  CONCLUSIONS
  Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes.
authors.affiliation: Medical Oncology & Breast Unit, 'A Perrino' Hospital, SS 7 Appia, 72100 Brindisi, Italy.
authors.forename: Palma
authors.initials: P
authors.lastname: Fedele
authors.forename: Laura
authors.initials: L
authors.lastname: Orlando
authors.forename: Paola
authors.initials: P
authors.lastname: Schiavone
authors.forename: Annamaria
authors.initials: A
authors.lastname: Quaranta
authors.forename: Assunta Maria
authors.initials: AM
authors.lastname: Lapolla
authors.forename: Maria
authors.initials: M
authors.lastname: De Pasquale
authors.forename: Antonino
authors.initials: A
authors.lastname: Ardizzone
authors.forename: Emilio
authors.initials: E
authors.lastname: Bria
authors.forename: Isabella
authors.initials: I
authors.lastname: Sperduti
authors.forename: Nicola
authors.initials: N
authors.lastname: Calvani
authors.forename: Antonella
authors.initials: A
authors.lastname: Marino
authors.forename: Chiara
authors.initials: C
authors.lastname: Caliolo
authors.forename: Enrica
authors.initials: E
authors.lastname: Mazzoni
authors.forename: Saverio
authors.initials: S
authors.lastname: Cinieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013629:Tamoxifen / Q000627:therapeutic use; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen
keywords: BMI; early-stage breast cancer; recurrence; weight gain; weight loss