title: A multicenter, randomized, double-blind clinical study to evaluate the efficacy and safety of PP-501-B in correction of nasolabial folds.
abstract: BACKGROUND
  Many new brands of hyaluronic acid (HA) fillers are being produced, but comparative research on the characteristics of similar products is limited.
  
  
  OBJECTIVE
  To test the efficacy, tolerability, and safety of a new HA filler, PP-501-B (Cleviel Contour; Pacific Pharma, Seoul, Korea), which is used for correcting nasolabial folds (NLFs), and to compare the performance of PP-501-B with that of Restylane Perlane (Q-Med).
  
  
  METHODS
  A total of 103 subjects with visible NLFs were enrolled in this randomized, multicenter, patient/evaluator-blind, active-controlled, matched-pair clinical study. Each subject was injected with PP-501-B in 1 NLF and Restylane Perlane in the other. All participants were reassessed for cosmetic changes at 8, 16, and 24 weeks. Wrinkle severity was rated using the 5-point Wrinkle Severity Rating Scale (WSRS).
  
  
  RESULTS
  At Week 24, the mean improvement in the WSRS compared with baseline was 1.87 ± 0.73 for the PP-501-B side and 1.92 ± 0.71 for the Restylane Perlane side. Both fillers were well tolerated, and adverse reactions were mild.
  
  
  CONCLUSIONS
  The new HA filler, PP-501-B, to the market, with suitable characteristics and ample safety profiles, will widen the selection of agents for physicians and patients because the purpose, area, and depth of filler injections vary.
authors.affiliation: *Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea; †Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ‡Department of Dermatology, KonKuk University College of Medicine, Seoul, Korea.
authors.forename: Kui Young
authors.initials: KY
authors.lastname: Park
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Ko
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Myeung Nam
authors.initials: MN
authors.lastname: Kim
authors.forename: Chang Kwun
authors.initials: CK
authors.lastname: Hong
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Yang Won
authors.initials: YW
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; C560019:Restylane Perlane; D006820:Hyaluronic Acid