title: The effect of childhood cancer therapy on ovarian reserve and pubertal development.
abstract: The effects of childhood cancer therapy on ovarian reserve tests and on pubertal development within 5 years were compared with a control group. The study group was composed of 41 patients who underwent chemotherapy during pre-menarche (subgroup A; n = 15) and after menarche (subgroup B; n = 26); the control group was composed of 44 patients admitted with non-cancer related diseases (in total n = 85). Mean total ovarian volume and total antral follicle counts on ultrasound examination were significantly lower in the study group compared with the control group (3.5 ± 2.3 versus 5.2 ± 2.4 ml; P = 0.001; and 3.4 ± 3.3 versus 8.6 ± 3.5; P < 0.001, respectively). Mean FSH level was significantly higher in the study group (13.5 ± 16.2 versus 7.3 ± 2.7 mIU/ml; P = 0.017). Anti-Müllerian hormone levels in subgroup A were significantly higher than in subgroup B (1.8 ± 0.1 versus 1.5 ± 0.08 pg/dl; P = 0.034). In conclusion ovarian volume, antral follicle count and FSH can be used for evaluating the harmful effect of cancer chemotherapy on ovarian follicles. Post-menarche, Anti-Müllerian values reveal that ovarian follicles are more sensitive to the devastating effects of cytotoxic treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey.
authors.forename: Bertan
authors.initials: B
authors.lastname: Akar
authors.affiliation: Department of Obstetrics and Gynecology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey. Electronic address: emekdoger@hotmail.com.
authors.forename: Emek
authors.initials: E
authors.lastname: Doğer
authors.affiliation: Department of Obstetrics and Gynecology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey.
authors.forename: Yiğit
authors.initials: Y
authors.lastname: Çakıroğlu
authors.affiliation: Department of Pediatric Oncology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Çorapçıoğlu
authors.affiliation: Department of Pediatric Hematology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Sarper
authors.affiliation: Department of Obstetrics and Gynecology, Kocaeli University Faculty of Medicine, Umuttepe 41380, Kocaeli, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Çalışkan
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood; D000970:Antineoplastic Agents / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects; D065851:Ovarian Reserve / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D011627:Puberty / Q000187:drug effects*; D017741:Survivors; D014463:Ultrasonography / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: childhood cancer therapy; ovarian reserve; puberty