title: Diet, behavior and immunity across the lifespan.
abstract: It is increasingly appreciated that perinatal events can set an organism on a life-long trajectory for either health or disease, resilience or risk. One early life variable that has proven critical for optimal development is the nutritional environment in which the organism develops. Extensive research has documented the effects of both undernutrition and overnutrition, with strong links evident for an increased risk for obesity and metabolic disorders, as well as adverse mental health outcomes. Recent work has highlighted a critical role of the immune system, in linking diet with long term health and behavioral outcomes. The present review will summarize the recent literature regarding the interactions of diet, immunity, and behavior.
authors.affiliation: School of Psychological Science, La Trobe University, Melbourne, VIC, Australia.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Hale
authors.affiliation: School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Melbourne, VIC, Australia. Electronic address: Sarah.Spencer@rmit.edu.au.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Spencer
authors.affiliation: The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Bruno
authors.initials: B
authors.lastname: Conti
authors.affiliation: Centre for Neuroendocrinology, Gravida: National Centre for Growth and Development, Department of Anatomy, University of Otago, Dunedin, New Zealand.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Jasoni
authors.affiliation: School of Psychological Science, La Trobe University, Melbourne, VIC, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kent
authors.affiliation: School of Psychological Science, La Trobe University, Melbourne, VIC, Australia.
authors.forename: Morgan E
authors.initials: ME
authors.lastname: Radler
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Reyes
authors.affiliation: School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Melbourne, VIC, Australia.
authors.forename: Luba
authors.initials: L
authors.lastname: Sominsky
mesh_terms: D000818:Animals; D001519:Behavior; D004032:Diet; D005260:Female; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008659:Metabolic Diseases / Q000209:etiology; D009765:Obesity / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology / Q000523:psychology
keywords: Calorie restriction; Cytokine; Diet; IL-18; Immune; Inflammation; Lipopolysaccharide; Microglia; Nutrition; Obesity