title: Genome-wide significant linkage to IgG subclass responses against Plasmodium falciparum antigens on chromosomes 8p22-p21, 9q34 and 20q13.
abstract: A genome-wide scan was conducted for the levels of total immunoglobulin G (IgG) and IgG subclasses directed against Plasmodium falciparum antigens in an urban population living in Burkina Faso. Non-parametric multipoint linkage analysis provided three chromosomal regions with genome-wide significant evidence (logarithm of the odds (LOD) score >3.6), and five chromosomal regions with genome-wide suggestive evidence (LOD score >2.2). IgG3 levels were significantly linked to chromosomes 8p22-p21 and 20q13, whereas IgG4 levels were significantly linked to chromosome 9q34. In addition, we detected suggestive linkage of IgG1 levels to chromosomes 18p11-q12 and 18q12-q21, IgG4 levels to chromosomes 1p31 and 12q24 and IgG levels to chromosome 6p24-p21. Moreover, we genotyped genetic markers located within the regions of interest in a rural population living in Burkina Faso. We detected genome-wide significant and suggestive linkage results when combining the two study populations for chromosomes 1p31, 6p24-p21, 8p22-p21, 9q34, 12q24 and 20q13. Because high anti-parasite IgG3 and low anti-parasite IgG4 levels were associated with malaria resistance, the chromosomal regions linked to IgG3 and IgG4 levels are of special interest. Although the results should be confirmed in an independent population, they may provide new insights in understanding both the genetic control of IgG production and malaria resistance.
authors.affiliation: 1] INSERM, UMR1090 TAGC, Marseille, France [2] Aix-Marseille Université, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Brisebarre
authors.affiliation: Université des Sciences et Techniques de Masuku, Institut National Supérieur d'Agronomie et de Biotechnologies, Franceville, Gabon.
authors.forename: B
authors.initials: B
authors.lastname: Kumulungui
authors.affiliation: University of Ouagadougou, UFR des Sciences de la Santé, Ouagadougou, Burkina Faso.
authors.forename: S
authors.initials: S
authors.lastname: Sawadogo
authors.affiliation: 1] INSERM, UMR1090 TAGC, Marseille, France [2] Aix-Marseille Université, Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Afridi
authors.affiliation: 1] Aix-Marseille Université, Marseille, France [2] UMR-MD3, Marseille, France.
authors.forename: F
authors.initials: F
authors.lastname: Fumoux
authors.affiliation: 1] INSERM, UMR1090 TAGC, Marseille, France [2] Aix-Marseille Université, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Rihet
mesh_terms: D000293:Adolescent; D000328:Adult; D000953:Antigens, Protozoan / Q000276:immunology*; D002050:Burkina Faso; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002890:Chromosomes, Human, Pair 20; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics* / Q000276:immunology*; D007223:Infant; D008126:Lod Score; D016778:Malaria, Falciparum / Q000235:genetics* / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D055815:Young Adult
chemical_list: D000953:Antigens, Protozoan; D007074:Immunoglobulin G