title: The association of nm23-H1 expression with a poor prognosis in patients with peripheral T-cell lymphoma, not otherwise specified.
abstract: nm23-H1 was originally identified as a protein that is expressed at a lower than usual level in metastatic cancer cells. The nm23 genes play critical roles in cellular proliferation, differentiation, oncogenesis, and tumor metastasis. Peripheral T-cell lymphoma (PTCL) is relatively rare, accounting for only 10% to 15% of non-Hodgkin's lymphomas. We examined whether nm23-H1 is a prognostic factor of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). PTCL is more aggressive and has a poorer prognosis than diffuse large B-cell lymphoma. nm23-H1 was positive in 44.1% of PTCL-NOS patients. nm23-H1 expression was not correlated with age, performance status (PS), lactate dehydrogenase (LDH) level, or stage. The nm23-H1-positive group had significantly shorter overall survival (OS). OS was significantly shorter in patients with the following clinicopathologic features: age ＞ 60 years, PS of 2-4, LDH ＞ normal, bone marrow involvement, or nm23-H1-positive lymphoma. The nm23-H1 protein may be an important prognostic factor in PTCL-NOS. Because our results suggest that nm23-HI is produced by lymphoma cells, we expect to see the development of new treatments targeting nm23 overexpression.
authors.affiliation: Department of Hematology, International Medical Center, Saitama Medical University.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Niitsu
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D054778:NM23 Nucleoside Diphosphate Kinases / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human