title: Twist-BRD4 complex: potential drug target for basal-like breast cancer.
abstract: As an important basic helix-loop-helix (bHLH) transcription factor, Twist associates with several physiological processes such as mesodermal development, and pathological processes such as Saethre-Chotzen syndrome. During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. Although many studies have revealed its multiple biological roles, it remained unclear how Twist transcriptionally activates targeted genes. Recently we discovered tip60-mediated Twist di-acetylation in the ''histone H4-mimic'' GK-X-GK motif. The di-acetylated Twist recruits BRD4 and related transcriptional components to super-enhancer of its targeted genes during progression of basal-like breast cancer (BLBC). Here, we review this new advance of regulation and functional mechanism of Twist.
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.forename: Jingying
authors.initials: J
authors.lastname: Cao
authors.affiliation: 750 Rose Street, Room 377, Lexington, KY 40536. peter.zhou@uky.edu.
authors.forename: Binhua P
authors.initials: BP
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins; D016503:Drug Delivery Systems / Q000639:trends*; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology; D051879:Twist-Related Protein 1 / Q000096:biosynthesis* / Q000235:genetics; D000092468:Bromodomain Containing Proteins
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D051879:Twist-Related Protein 1; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C103173:TWIST1 protein, human