title: Association of 49245A>G (rs868) polymorphism in the 3'UTR of donor TGFBR1 gene with course of hepatitis C following orthotopic liver transplantation.
abstract: BACKGROUND
  Terminal hepatitis C is one of the leading indications for orthotopic liver transplantation (OLT). However, hepatitis C virus (HCV) reinfection occurs in almost all recipients and usually leads to progressive fibrosis and graft failure. Transforming growth factor-b (TGF-β) plays a part in transplanted liver cirrhosis, but nothing is known about the possible role of genetic diversity of TGF-β receptor system. Therefore, the aim of our study was to investigate whether genetic variation in 3' untranslated region (3'UTR) of TGF-β receptor type I (TGFBR1) gene is associated with recurrence and severity of hepatitis C and liver fibrosis following OLT in HCV-infected patients.
  
  
  METHODS
  The study group included 95 chronic hepatitis C patients following OLT. The recipients and donors were genotyped for 49245A>G (rs868) and 51976G>A (rs334349) single nucleotide polymorphisms (SNP).
  
  
  RESULTS
  Donor rs868 AA genotype was strongly associated with worse clinical course of recurrent hepatitis C. The rs868 AA group displayed more severe symptoms of hepatitis C during the follow-up and the fibrosis score in this group was significantly higher 3 years after OLT.
  
  
  CONCLUSIONS
  Clinical course of hepatitis C after OLT may depend on donor rs868 SNP located in TGFBR1 3'UTR.
authors.affiliation: Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Bogna
authors.initials: B
authors.lastname: Ziarkiewicz-Wróblewska
authors.affiliation: Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Emir
authors.initials: E
authors.lastname: Sajjad
authors.affiliation: Department of Immunology, Transplantology and Internal Medicine, Institute of Transplantology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Ciszek
authors.affiliation: Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Hutnik
authors.affiliation: Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Łukasik
authors.affiliation: Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Fedorowicz
authors.affiliation: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Wróblewski
authors.affiliation: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Patkowski
authors.affiliation: Department of Immunology, Transplantology and Internal Medicine, Institute of Transplantology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Pączek
authors.affiliation: Department of Medical Genetics, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Płoski
authors.affiliation: Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Włodarski
authors.affiliation: Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Malejczyk
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics / Q000601:surgery*; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D012008:Recurrence; D012720:Severity of Illness Index; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D020413:3' Untranslated Regions; D005819:Genetic Markers; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human