title: Multinational comprehensive evaluation of the fixation method used in hip replacement: interaction with age in context.
abstract: BACKGROUND
  Fixation in total hip replacements remains a controversial topic, despite the high level of its success. Data obtained from major orthopaedic registries indicate that there are large differences among preferred fixation and survival results.
  
  
  METHODS
  Using a distributed registry data network, primary total hip arthroplasties performed for osteoarthritis from 2001 to 2010 were identified from six national and regional total joint arthroplasty registries. A multivariate meta-analysis was performed using linear mixed models with the primary outcome revision for any reason. Survival probabilities and their standard errors were extracted from each registry for each unique combination of the covariates. Fixation strategies were compared with regard to age group, sex, bearing, and femoral-head diameter. All comparisons were based on the random-effects model and the fixed-effects model.
  
  
  RESULTS
  In patients who were seventy-five years of age and older, uncemented fixation had a significantly higher risk of revision (p < 0.001) than hybrid fixation, with a hazard ratio of 1.575 (95% confidence interval, 1.389 to 1.786). We found a similar, if lesser, effect in the intermediate age group of sixty-five to seventy-four years (hazard ratio, 1.16 [95% confidence interval, 1.023 to 1.315]; p = 0.021) and in the younger age group of forty-five to sixty-four years (hazard ratio, 1.205 [95% confidence interval, 1.008 to 1.442]; p = 0.041). There were no significant differences between hybrid and cemented bearings across age groups.
  
  
  CONCLUSIONS
  We conclude that cementless fixation should be avoided in older patients (those seventy-five years of age or older), although this evidence is less strong in patients of intermediate and younger ages.
authors.affiliation: Registro dell'implantologia Protesica Ortopedica (R.I.P.O.) (Register of the Orthopaedic Prosthetic Implants), c/o Medical Technology Laboratory, Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Stea
authors.affiliation: HealthEast Joint Registry (HEJR), 1690 University Avenue West, Data Science, Suite 400, Minneapolis, MN 55104.
authors.forename: Thomas
authors.initials: T
authors.lastname: Comfort
authors.affiliation: Weill Cornell Medical College, 402 East 67th Street, New York, NY 10065.
authors.forename: Art
authors.initials: A
authors.lastname: Sedrakyan
authors.affiliation: The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Mollendalsbakken 11, N-5021 Bergen, Norway.
authors.forename: Leif
authors.initials: L
authors.lastname: Havelin
authors.affiliation: Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Carrer de Roc Boronat, 81-95 2a planta, 08005, Barcelona, Spain.
authors.forename: Marcella
authors.initials: M
authors.lastname: Marinelli
authors.affiliation: Department of Orthopedic Surgery, Kaiser Permanente, 280 West MacArthur Boulevard, Oakland, CA 94611.
authors.forename: Thomas
authors.initials: T
authors.lastname: Barber
authors.affiliation: Surgical Outcomes & Analysis Department, Kaiser Permanente, 8954 Rio San Diego Drive, Suite 406, San Diego, CA 92108.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Paxton
authors.affiliation: Weill Cornell Medical College, 402 East 67th Street, New York, NY 10065.
authors.forename: Samprit
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Weill Cornell Medical College, 402 East 67th Street, New York, NY 10065.
authors.forename: Abby J
authors.initials: AJ
authors.lastname: Isaacs
authors.affiliation: Australian Orthopaedic Association National Joint Replacement Registry, Discipline of Public Health, University of Adelaide, MDP DX 65011, Adelaide, SA 5005, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Graves
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D002484:Cementation; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery*; D011474:Prosthesis Design; D012042:Registries; D012086:Reoperation