title: Impact of platelet phenotype on myocardial infarction.
abstract: In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.
authors.affiliation: Institute of Experimental Cardiology, Cardiology Research Center , Moscow , Russia .
authors.forename: Zufar
authors.initials: Z
authors.lastname: Gabbasov
authors.forename: Jan
authors.initials: J
authors.lastname: Sabo
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovic
authors.forename: Nieves
authors.initials: N
authors.lastname: Martell-Claros
authors.forename: Angela
authors.initials: A
authors.lastname: Zagatina
authors.forename: Igor
authors.initials: I
authors.lastname: Mrdovic
authors.forename: Rachele
authors.initials: R
authors.lastname: Ciccocioppo
authors.forename: Giuseppina Cristina
authors.initials: GC
authors.lastname: Cangemi
authors.forename: Jan
authors.initials: J
authors.lastname: Klimas
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D008565:Membrane Proteins
keywords: Acute coronary syndrome; cardiovascular risk; myocardial infarction; platelet phenotype; platelets