title: Low-temperature chemical synthesis of high-purity diacylglycerols (DAG) from monoacylglycerols (MAG).
abstract: A chemical method was developed for low-temperature synthesis of DAG from MAG followed by an easy purification procedure in order to obtain high-purity DAG. Solvent-assisted and solvent-free reaction conditions were used, combined with different catalysts (sodium methoxide, p-toluenesulfonic acid, methanesulfonic acid, and sulfuric acid). All reactions were performed at 35 and 70 °C. By increasing both acidity and polarity of the catalyst the equilibrium shifts towards the formation of DAG. When using sulfuric acid in solvent-assisted condition at 70 °C, 88% conversion was obtained after 20 min of reaction (77% w/w DAG in the reaction mixture after evaporation of the solvent). After purifying by means of column chromatography, 96% pure DAG were obtained. The overall yield of DAG was 81%.
authors.affiliation: Faculty of Applied Engineering, University of Antwerp, Salesianenlaan 90, 2660, Hoboken, Belgium.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Pazdur
authors.forename: Jeroen
authors.initials: J
authors.lastname: Geuens
authors.forename: Hannes
authors.initials: H
authors.lastname: Sels
authors.forename: Serge M F
authors.initials: SM
authors.lastname: Tavernier
mesh_terms: D002384:Catalysis; D003080:Cold Temperature; D004075:Diglycerides / Q000138:chemical synthesis*; D004951:Esterification; D050178:Monoglycerides / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013464:Sulfuric Acids / Q000737:chemistry
chemical_list: D004075:Diglycerides; D050178:Monoglycerides; D012997:Solvents; D013464:Sulfuric Acids; C033158:sulfuric acid