title: Iron catalysed cross-couplings of azetidines - application to the formal synthesis of a pharmacologically active molecule.
abstract: A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. Magnus.Rueping@rwth-aachen.de.
authors.forename: Dixit
authors.initials: D
authors.lastname: Parmar
authors.forename: Lena
authors.initials: L
authors.lastname: Henkel
authors.forename: Josef
authors.initials: J
authors.lastname: Dib
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
mesh_terms: D001384:Azetidines / Q000737:chemistry*; D002384:Catalysis; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D007501:Iron / Q000737:chemistry*
chemical_list: D001384:Azetidines; D002491:Central Nervous System Agents; D007501:Iron