title: Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.
abstract: Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activation of Matrix Metalloproteinases (MMPs) and inflammatory responses hence damaging the extracellular matrix (ECM) components. To counter this, an exogenous supply of anti-oxidants, is required since the endogenous anti-oxidant system cannot alone suffice the need. Bio-prospecting of natural resources for anti-oxidants has hence been intensified. Immense research is being carried out to identify potential plants with potent anti-oxidant activity against skin ageing. This review summarizes the major factors responsible for premature skin ageing and the plants being targeted to lessen the impact of those.
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307 Uttar Pradesh, India.
authors.lastname: Tanuja Yadav
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307 Uttar Pradesh, India.
authors.forename: Shivangi
authors.initials: S
authors.lastname: Mishra
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307 Uttar Pradesh, India.
authors.forename: Shefali
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307 Uttar Pradesh, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Aggarwal
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307 Uttar Pradesh, India. Electronic address: vibha.rani@jiit.ac.in.
authors.forename: Vibha
authors.initials: V
authors.lastname: Rani
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D010936:Plant Extracts; D017382:Reactive Oxygen Species
keywords: Anti-ageing; Antioxidants; Extracellular matrix; Matrix Metalloproteinases; Reactive Oxygen Species; Ultraviolet radiation