title: Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome.
abstract: OBJECTIVE
  In the present study, we evaluated the association of rs662799 variant of the APOA5 gene with Metabolic syndrome (MetS) in a sample of children and adolescents from Isfahan.
  
  
  METHODS
  This case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction-restriction fragment length polymorphism (mPCR-RFLP) was used to genotype -1131T>C polymorphism. Findings : No significant association was documented for APOA5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the MetS was 0.38 (0.139-1.0350 and 0.29 (0.08-1.071 for the unadjusted and adjusted models, respectively.
  
  
  CONCLUSIONS
  This study suggests that among studied children and adolescents, -1131T>C polymorphism in the APOA5 gene may not be a major contributor to the MetS risk.
authors.affiliation: Department of Genetics, School of Basic Sciences.
authors.forename: Sayedeh Ghazaleh
authors.initials: SG
authors.lastname: Fatemi
authors.affiliation: Department of Genetics, School of Basic Sciences ; Research Institute of Biotechnology, School of Basic Sciences, Shahrekord University, Shahrekord.
authors.forename: Modjtaba
authors.initials: M
authors.lastname: Emadi-Baygi
authors.affiliation: Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan ; Department of Genetics and Molecular Biology, School of Medicine ; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Nikpour
authors.affiliation: Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.affiliation: Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Hashemipour
keywords: Apolipoprotein A5 Gene; Metabolic Syndrome; Children; Adolescents; Triglyceride; Cholesterol