title: Early hemodynamic effects after extended liver radiofrequency ablation.
abstract: BACKGROUND
  The purpose of the present study was to assess early intestinal and systemic hemodynamic effects after extended radiofrequency ablation (RFA) of the liver in terms of investigating their potential contribution to gut barrier disruption.
  
  
  METHODS
  Ten rabbits were assigned to two groups of five animals each and were subjected to either 30% liver RFA (group RFA-1) or sham operation (group sham-1). Blood flow rate at the superior mesenteric artery (SMA) was monitored for 90 min after operation. Ileal tissue was excised at 48 h for histomorphometric and histopathologic analysis. Eight pigs were assigned to two groups of four animals each and were also subjected to either 30% liver RFA (group RFA-2) or sham operation (group sham-2). A panel of systemic hemodynamic parameters was serially measured up to 90 min after operation.
  
  
  RESULTS
  In group RFA-1, SMA blood flow rate was lower than that in group sham-1 throughout the study period. Intestinal mucosa atrophy and a deterioration of histopathologic profile were noted in group RFA-1. In group RFA-2, diastolic pulmonary artery pressure was lower (60-90 min), central venous pressure was gradually decreased, arterial pressure was higher (30-90 min), and systemic vascular resistance was higher (30-90 min) than those in group sham-2. No change was noted in the cardiac output.
  
  
  CONCLUSIONS
  In conclusion, SMA blood flow was reduced during the early post-RFA period, justifying an ischemic insult at the intestine. In addition, a gradual decrease of the preload was counterbalanced by an increase of systemic vascular resistance leaving the cardiac output unaffected.
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. Electronic address: pipsil@med.duth.gr.
authors.forename: Petros
authors.initials: P
authors.lastname: Ypsilantis
authors.affiliation: Department of Cardiothoracic Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Didilis
authors.affiliation: Department of Anaesthesiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Savvas
authors.initials: S
authors.lastname: Eleftheriadis
authors.affiliation: Laboratory of Histology and Embryology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Lambropoulou
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Varsamis
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Simopoulos
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics; D007410:Intestinal Diseases / Q000209:etiology* / Q000473:pathology; D007422:Intestines / Q000098:blood supply* / Q000473:pathology; D008099:Liver / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011817:Rabbits; D011897:Random Allocation; D015427:Reperfusion Injury / Q000209:etiology*; D013552:Swine
keywords: Ablation; Hemodynamics; Liver; Radiofrequency