title: Pathobiology of ovarian carcinomas.
abstract: Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.
authors.affiliation: Department of Pathology, Hôpital de la Croix Rousse, 69317 Lyon Cedex 04, France. catherine.genestie@gustaveroussy.fr.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Devouassoux-Shisheboran
authors.forename: Catherine
authors.initials: C
authors.lastname: Genestie
mesh_terms: D018269:Carcinoma, Endometrioid / Q000473:pathology; D000077216:Carcinoma, Ovarian Epithelial; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000473:pathology; D005260:Female; D006801:Humans; D018198:Mixed Tumor, Malignant / Q000473:pathology; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*