title: Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats.
abstract: The individual weight loss response to obesity treatment is diverse. Here we test the hypothesis that the weight loss response to the CB1 receptor antagonist rimonabant is influenced by endogenous levels of receptor agonists. We show that baseline anandamide levels and body weight independently contribute to predict the treatment response to rimonabant in rodents, demonstrating that addition of biomarkers related to mode of action is relevant for a personalized health care approach to obesity treatment.
authors.affiliation: CVMD Translational Medicine Unit, Early Clinical Development (C.K., B.C.), CVMD Bioscience (S.H.), and CVMD Translational Sciences (G.I.H.), Innovative Medicines, and Biomedical Informatics (M.K.), Advanced Analytics Centre, AstraZeneca R&D, SE-431 83, Mölndal, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Karlsson
authors.forename: Stephan
authors.initials: S
authors.lastname: Hjorth
authors.forename: Martin
authors.initials: M
authors.lastname: Karpefors
authors.forename: Göran I
authors.initials: GI
authors.lastname: Hansson
authors.forename: Björn
authors.initials: B
authors.lastname: Carlsson
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000097:blood*; D001835:Body Weight / Q000502:physiology*; D063387:Cannabinoid Receptor Antagonists / Q000494:pharmacology*; D063388:Endocannabinoids / Q000097:blood*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000097:blood*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors*; D000077285:Rimonabant; D015431:Weight Loss / Q000187:drug effects* / Q000502:physiology*
chemical_list: D001095:Arachidonic Acids; D063387:Cannabinoid Receptor Antagonists; D063388:Endocannabinoids; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D000077285:Rimonabant; C078814:anandamide