title: Insulin resistance is associated with intraocular pressure elevation in a non-obese Korean population.
abstract: Based on reports of an association between elevated intraocular pressure (IOP) and metabolic syndrome (MetS), and the major role of insulin resistance (IR) in MetS pathogenesis, a positive association between IOP and IR has been hypothesized. Although Asian populations tend to have lower body mass indices (BMIs) than Western populations, they tend to have a higher risk of developing MetS. This study examined the hypothesis that the association between IOP and IR differs by obesity status in an Asian population, by examining a nationally representative sample of South Korean adults. Data collected from 4,621 South Korean adults regarding demographic, lifestyle, and laboratory parameters by the 2010 Korea National Health and Nutrition Examination Survey were subjected to linear regression analysis to evaluate the relationship between IOP and metabolic profiles. After adjusting for confounding factors, the data were subjected to multiple linear regression analysis to examine the association between IR, as measured by the homeostasis model assessment of insulin resistance (HOMA-IR), and IOP. Obesity was defined as BMI≥27.5 kg/m2, and the subjects were divided into obese vs. non-obese groups for investigation of the association between IR and IOP according to obesity status. IOP was found to correlate with fasting blood sugar, total cholesterol, insulin, and HOMA-IR values in non-obese men; and with BMI, waist circumference, triglycerides, total cholesterol, HOMA-IR, and low-density lipoprotein cholesterol values in non-obese women, whereas no association between IOP and IR was found in obese men or women. IOP was significantly associated with IR in non-obese men and women after adjusting for age, and in non-obese men after adjusting for age, BMI, and lifestyle and demographic factors. These findings indicate that a positive and independent relationship exists between IOP and IR in non-obese individuals only, suggesting that other factors likely contribute to IOP elevation in obese individuals.
authors.affiliation: Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yoon Hong
authors.initials: YH
authors.lastname: Chun
authors.affiliation: Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Kyungdo
authors.initials: K
authors.lastname: Han
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Shin Hae
authors.initials: SH
authors.lastname: Park
authors.affiliation: School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Kyung-Min
authors.initials: KM
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyeon Woo
authors.initials: HW
authors.lastname: Yim
authors.affiliation: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yong Gyu
authors.initials: YG
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, United States of America.
authors.forename: Yong-Moon
authors.initials: YM
authors.lastname: Park
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D044466:Asian People; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology / Q000502:physiology*; D007429:Intraocular Pressure / Q000502:physiology*; D016014:Linear Models; D008297:Male; D055442:Metabolome / Q000502:physiology; D055432:Metabolomics; D008875:Middle Aged; D009749:Nutrition Surveys / Q000379:methods* / Q000706:statistics & numerical data*; D009765:Obesity / Q000503:physiopathology; D056910:Republic of Korea