title: Management of viral hepatitis in liver transplant recipients.
abstract: Recurrence of viral hepatitis after liver transplantation (LT) can progress to graft failure and lead to a decrease in long-term survival. Recently, there have been remarkable improvement in the treatment of chronic hepatitis B (CHB) using potent antiviral agents. Combination of hepatitis B immunoglobulin and potent antiviral therapy has brought marked advances in the management of CHB for liver transplant recipients. Post-transplant antiviral therapy for hepatitis C virus infection is generally reserved for patients showing progressive disease. Acheiving a sustained virological response in patients with LT greatly ameliorates graft and overall survival, however this only occurs in 30% of transplant recipient using pegylated interferon and ribavirin (RBV). Direct acting antivirals such as protease inhibitors, polymerase or other non-structural proteins inhibitors are anticipated to establish the new standard of care for transplant recipients. In liver transplant recipients, hepatitis E virus infection is an uncommon disease. However, it can lead to chronic hepatitis and cirrhosis and may require retransplantation. Recently, 3-month course of RBV monotherapy has been reported as an effective treatment. This review focuses on the recent management and therapeutic approaches of viral hepatitis in liver transplant recipient.
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
authors.forename: Soung Won
authors.initials: SW
authors.lastname: Jeong
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: YoungRok
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D006509:Hepatitis B / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006526:Hepatitis C / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016751:Hepatitis E / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D012008:Recurrence
chemical_list: D000998:Antiviral Agents
keywords: Antiviral therapy; Liver transplantation; Management; Recurrence; Viral hepatitis