title: Mathematical and computational modeling in biology at multiple scales.
abstract: A variety of topics are reviewed in the area of mathematical and computational modeling in biology, covering the range of scales from populations of organisms to electrons in atoms. The use of maximum entropy as an inference tool in the fields of biology and drug discovery is discussed. Mathematical and computational methods and models in the areas of epidemiology, cell physiology and cancer are surveyed. The technique of molecular dynamics is covered, with special attention to force fields for protein simulations and methods for the calculation of solvation free energies. The utility of quantum mechanical methods in biophysical and biochemical modeling is explored. The field of computational enzymology is examined.
authors.affiliation: Department of Physics and Department of Oncology, University of Alberta, Edmonton, Canada. jackt@ualberta.ca.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Tuszynski
authors.forename: Philip
authors.initials: P
authors.lastname: Winter
authors.forename: Diana
authors.initials: D
authors.lastname: White
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Tseng
authors.forename: Kamlesh K
authors.initials: KK
authors.lastname: Sahu
authors.forename: Francesco
authors.initials: F
authors.lastname: Gentile
authors.forename: Ivana
authors.initials: I
authors.lastname: Spasevska
authors.forename: Sara Ibrahim
authors.initials: SI
authors.lastname: Omar
authors.forename: Niloofar
authors.initials: N
authors.lastname: Nayebi
authors.forename: Cassandra Dm
authors.initials: CD
authors.lastname: Churchill
authors.forename: Mariusz
authors.initials: M
authors.lastname: Klobukowski
authors.forename: Rabab M Abou
authors.initials: RM
authors.lastname: El-Magd
mesh_terms: D003198:Computer Simulation; D019277:Entropy; D056004:Molecular Dynamics Simulation