title: Genetic polymorphism in pathogenesis of irritable bowel syndrome.
abstract: Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to ROME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS.
authors.affiliation: Cynthia KY Cheung, Justin CY Wu, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Cynthia K Y
authors.initials: CK
authors.lastname: Cheung
authors.affiliation: Cynthia KY Cheung, Justin CY Wu, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Justin C Y
authors.initials: JC
authors.lastname: Wu
mesh_terms: D016207:Cytokines / Q000235:genetics*; D003672:Defecation / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D009479:Neuropeptides / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors
chemical_list: D016207:Cytokines; D005819:Genetic Markers; D009479:Neuropeptides
keywords: Cytokines; Endocannabinoids; Genetic polymorphism; Irritable bowel syndrome; Psychiatric distress; Serotonin