title: Metabolic and feeding behavior alterations provoked by prenatal exposure to aspartame.
abstract: The use of artificial sweeteners has increased together with the epidemic growth of obesity. In addition to their widespread use in sodas, artificial sweeteners are added to nearly 6000 other products sold in the US, including baby foods, frozen dinners and even yogurts. It has been suggested that the use of nonnutritive sweeteners can lead to body weight gain and an altered metabolic profile. However, very few studies have evaluated the effects of maternal consumption of artificial non-caloric sweeteners on body weight, feeding behavior or the metabolism of offspring in adult life. In this study, we found that animals exposed to aspartame during the prenatal period presented a higher consumption of sweet foods during adulthood and a greater susceptibility to alterations in metabolic parameters, such as increased glucose, LDL and triglycerides. These effects were observed in both males and females, although they were more pronounced in males. Despite the preliminary nature of this study, and the need for further confirmation of these effects, our data suggest that the consumption of sweeteners during gestation may have deleterious long-term effects and should be used with caution.
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil. Electronic address: edutoigo@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: von Poser Toigo
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: A P
authors.initials: AP
authors.lastname: Huffell
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: Mota
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Bertolini
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: L F
authors.initials: LF
authors.lastname: Pettenuzzo
authors.affiliation: Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Dalmaz
mesh_terms: D000818:Animals; D001218:Aspartame / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D008297:Male; D023421:Models, Animal; D064306:Non-Nutritive Sweeteners / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D064306:Non-Nutritive Sweeteners; D014280:Triglycerides; D001218:Aspartame
keywords: Artificial sweeteners; Aspartame; Feeding behavior; Gestation; Metabolism; Obesity