title: Copper(I)-catalyzed cycloaddition of 4-bromosydnones and alkynes for the regioselective synthesis of 1,4,5-trisubstituted pyrazoles.
abstract: Copper-catalyzed cycloaddition of alkynes with 4-bromosydnones provides a convenient, mild, and regioselective method for the synthesis of a wide range of bromopyrazoles. The broad functional group tolerance of the cycloaddition reaction and further palladium-catalyzed cross-coupling reactions allowed the preparation of polyfunctionalized 1,4,5-pyrazoles that are otherwise difficult to obtain by conventional methods.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage , Gif sur Yvette F-91191, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Decuypere
authors.forename: Simon
authors.initials: S
authors.lastname: Specklin
authors.forename: Sandra
authors.initials: S
authors.lastname: Gabillet
authors.forename: Davide
authors.initials: D
authors.lastname: Audisio
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Lucie
authors.initials: L
authors.lastname: Plougastel
authors.forename: Sergii
authors.initials: S
authors.lastname: Kolodych
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013558:Sydnones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D011720:Pyrazoles; D013558:Sydnones; D003300:Copper