title: Antimicrobial properties of substituted quino[3,2-b]benzo[1,4]thiazines.
abstract: Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF a) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl- 2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.
authors.forename: Anna
authors.initials: A
authors.lastname: Czarny
authors.forename: Ewa
authors.initials: E
authors.lastname: Zaczyńska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jeleń
authors.forename: Michał
authors.initials: M
authors.lastname: Zimecki
authors.forename: Krystian
authors.initials: K
authors.lastname: Pluta
authors.forename: Beata
authors.initials: B
authors.lastname: Morak-Młodawska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Artym
authors.forename: Maja
authors.initials: M
authors.lastname: Kocięba
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013843:Thiazines