title: DESIGN, SYNTHESIS, AND EVALUATION OF A FAMILY OF PROPARGYL PYRIDINYL ETHERS AS POTENTIAL CYTOCHROME P450 INHIBITORS.
abstract: Cytochrome P450 enzymes are a superfamily of hemoproteins involved in the metabolism of endogenous and exogenous compounds including many drugs and environmental chemicals. In our previous research, we have determined that certain aryl and arylalkyl acetylenes act as inhibitors of these enzymes. Here we report a family of propargyl ethers containing a pyridine ring system. Five new compounds, 2,4-dimethyl-3-(prop-2-yn-1-yloxy)pyridine(I), 2,4-dimethyl-3-((prop-2-yn-1-yloxy) methyl)pyridine(II), 2,3-dimethyl-4-((prop-2-yn-1-yloxy)methyl)pyridine(III), 2-methyl-4-((prop-2-yn-1-yloxy)methyl)pyridine (IV), 2-methyl-4-(prop-2-yn-1-yloxy)pyridine (V) (Figure 1) have been synthesized and characterized.
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Maryam
authors.initials: M
authors.lastname: Foroozesh
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Quan
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Jayalakshmi
authors.initials: J
authors.lastname: Sridhar
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Jiawang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.lastname: Minaruzzaman
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Brandan
authors.initials: B
authors.lastname: Dotson
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125.
authors.forename: Erika
authors.initials: E
authors.lastname: McClain
keywords: Acetylenes; Cytochrome P450 enzymes; Enzyme inhibitors; Metabolism; Organic synthesis; Propargyl pyridinyl ethers; Suicide inhibition