title: The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivo.
abstract: Drug delivery nanocarriers, especially targeted drug delivery by liposomes are emerging as a class of therapeutics for cancer. Early research results suggest that liposomal therapeutics enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumors and active cellular uptake. Here, we highlight the features of immunoliposomes that distinguish them from previous anticancer therapies, and describe how these features provide the potential for therapeutic effects that are not achievable with other modalities. While a large number of studies has been published, the emphasis here is placed on the carbonic anhydrase IX (CA-IX) and the conjugated liposomes that are likely to open a new chapter on drug delivery system by using immunoliposomes to deliver anticancer ingredients to cancer cells in vivo.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong 999077, China. helena_ng@hkbu.edu.hk.
authors.forename: Huei Leng Helena
authors.initials: HL
authors.lastname: Ng
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong 999077, China. aipinglu@hkbu.edu.hk.
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu
authors.affiliation: School of Biomedical Sciences, Chinese University of Hong Kong, Area 39, CUHK, Shatin, NT, Hong Kong 999077, China. linge@cuhk.edu.hk.
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong 999077, China. qin@ort.cuhk.edu.hk.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong 999077, China. yzhijun@hkbu.edu.hk.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002256:Carbonic Anhydrases / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D002256:Carbonic Anhydrases