title: 'Bio-nano interactions: new tools, insights and impacts': summary of the Royal Society discussion meeting.
abstract: Bio-nano interactions can be defined as the study of interactions between nanoscale entities and biological systems such as, but not limited to, peptides, proteins, lipids, DNA and other biomolecules, cells and cellular receptors and organisms including humans. Studying bio-nano interactions is particularly useful for understanding engineered materials that have at least one dimension in the nanoscale. Such materials may consist of discrete particles or nanostructured surfaces. Much of biology functions at the nanoscale; therefore, our ability to manipulate materials such that they are taken up at the nanoscale, and engage biological machinery in a designed and purposeful manner, opens new vistas for more efficient diagnostics, therapeutics (treatments) and tissue regeneration, so-called nanomedicine. Additionally, this ability of nanomaterials to interact with and be taken up by cells allows nanomaterials to be used as probes and tools to advance our understanding of cellular functioning. Yet, as a new technology, assessment of the safety of nanomaterials, and the applicability of existing regulatory frameworks for nanomaterials must be investigated in parallel with development of novel applications. The Royal Society meeting 'Bio-nano interactions: new tools, insights and impacts' provided an important platform for open dialogue on the current state of knowledge on these issues, bringing together scientists, industry, regulatory and legal experts to concretize existing discourse in science law and policy. This paper summarizes these discussions and the insights that emerged.
authors.affiliation: School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, UK i.lynch@bham.ac.uk.
authors.forename: Iseult
authors.identifier: http://orcid.org/0000-0003-4250-4584
authors.initials: I
authors.lastname: Lynch
authors.affiliation: Institute for Work and Health, University of Lausanne, Vaud, 1015 Lausanne, Switzerland.
authors.forename: Ilise L
authors.initials: IL
authors.lastname: Feitshans
authors.affiliation: School of Metallurgy and Materials, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Michaela
authors.initials: M
authors.lastname: Kendall
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011506:Proteins / Q000737:chemistry*
chemical_list: D008055:Lipids; D011506:Proteins; D004247:DNA
keywords: advanced materials; bio-nano interface; biomolecule corona; nanomedicine; nanoregulation; nanosafety