title: Accumulation of abdominal fat in relation to selected proinflammatory cytokines concentrations in non-obese Wrocław inhabitants.
abstract: BACKGROUND
  Metabolically obese normal weight (MONW) subjects, despite their normal BMI, present metabolic disturbances characteristic of abdominal obesity. One of the reasons might be subclinical inflammation caused by the fat tissue excess. The aim of this study was to assess the association between the accumulation of fat (especially abdominal) and the concentration of selected proinflammatory cytokines - interleukins (IL-6, IL-18) and C-reactive protein (CRP).
  
  
  METHODS
  The study population consisted of 342 subjects (218 women, 124 men; age 20-40 years, BMI < 27 kg/m2) recruited from a community centre in Wroclaw. The group was divided based on the homeostasis assessment insulin resistance index (HOMA) value: 90 MONW subjects with HOMA > 1.69 and 252 subjects as control group. Anthropometric parameters, serum IL-6, IL-18, CRP, glucose, insulin concentrations and insulin sensitivity/resistance indexes were evaluated.
  
  
  RESULTS
  CRP levels were significantly higher (3.26 vs. 1.97, p = 0.03) in MONW women than in the control group. Serum IL-6, IL-18 levels in males and females did not differ in both groups. IL-6 showed a significant correlation with the abdominal to gynoidal fat tissue deposit ratio in women. There were correlations between the CRP and BMI, WHR, waist circumference, total fat, abdominal fat deposit, and abdominal to gynoidal fat deposit ratio in both sexes. In women, positive correlations between CRP and HOMA, FIRI and negative with QUICKI index were present.
  
  
  CONCLUSIONS
  Increased accumulation of abdominal adipose tissue in non-obese, young and healthy subjects is related to increased CRP levels.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Bednarek-Tupikowska
authors.affiliation: Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland. aleksandrazdr@gmail.com.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zdrojowy-Wełna
authors.forename: Barbara
authors.initials: B
authors.lastname: Stachowska
authors.forename: Justyna
authors.initials: J
authors.lastname: Kuliczkowska-Płaksej
authors.forename: Magdalena
authors.initials: M
authors.lastname: Matczak-Giemza
authors.forename: Eliza
authors.initials: E
authors.lastname: Kubicka
authors.forename: Urszula
authors.initials: U
authors.lastname: Tworowska-Bardzińska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
authors.forename: Marek
authors.initials: M
authors.lastname: Bolanowski
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009765:Obesity / Q000276:immunology / Q000378:metabolism*; D011044:Poland; D017678:Sex Distribution; D014505:Urban Population / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin; D020382:Interleukin-18; D015850:Interleukin-6; D002097:C-Reactive Protein