title: Discovery of anti-malarial agents through application of in silico studies.
abstract: Among the various parasitic diseases, malaria is the deadliest one. Due to the emergence of high drug resistance to the existing drug candidates there is a global need for development of new drug candidates which will be effective against resistant strains of malaria parasite. In silico molecular modeling approaches have been playing an important role in the discovery of novel lead molecules having antimalarial activity. Present review is an effort to cover all the developments related to the application of computational techniques for the design and discovery of novel antimalarial compounds since the year 2011 onwards.
authors.forename: Mahesh A
authors.initials: MA
authors.lastname: Barmade
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Murumkar
authors.forename: Mayank Kumar
authors.initials: MK
authors.lastname: Sharma
authors.forename: Kaushik P
authors.initials: KP
authors.lastname: Shingala
authors.forename: Rajani R
authors.initials: RR
authors.lastname: Giridhar
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara- 390 001, Gujarat, India. mryadav11@yahoo.co.in.
authors.forename: Mange Ram
authors.initials: MR
authors.lastname: Yadav
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D017076:Computer-Aided Design; D015195:Drug Design; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008958:Models, Molecular; D010961:Plasmodium / Q000187:drug effects*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000962:Antimalarials