title: Antioxidant activity and cytotoxicity on tumour cells of the essential oil from Cedronella canariensis var. canariensis (L.) Webb & Berthel. (Lamiaceae).
abstract: Cedronella canariensis is a lemon-scented species of the family Lamiaceae endemic to the Canary Islands where it is used in the traditional medicine to prepare infusions or inhalations for anti-catarrhal, tonic, diuretic, hypoglycaemiant, hypotensive, anti-inflammatory and decongestant of the respiratory tract. In this work we investigated for the first time the antioxidant activity of the essential oil and its inhibitory effects on tumour cells (A375, MDA-MB-231, HCT 116) proliferation by DPPH, ABTS, FRAP and MTT assays, respectively. The oil, analysed by GC-ionisation flame detector and GC-MS, was characterised by pinocarvone (58.0%) and β-pinene (10.8%) as the major constituents, being typical of the chemotype 'canariensis'. Noteworthy was the cytotoxic activity of the oil against the tumour cells examined, with IC50 values of 4.3, 7.3 and 11.4 μg/mL on A375, MDA-MB-231 and HCT 116 tumour cells, respectively, as well as the scavenging activity against the ABTS radical (IC50 of 10.5 μg/mL).
authors.affiliation: a Departamento de Medicina Física y Farmacología , Facultad de Farmacia, Universidad de La Laguna , Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna (Tenerife) , Spain.
authors.forename: Christian
authors.initials: C
authors.lastname: Zorzetto
authors.forename: Candelaria C
authors.initials: CC
authors.lastname: Sánchez-Mateo
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Rabanal
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.forename: Romilde
authors.initials: R
authors.lastname: Iannarelli
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D045325:HCT116 Cells / Q000187:drug effects; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D039821:Monoterpenes / Q000494:pharmacology; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D013030:Spain
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D016166:Free Radical Scavengers; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; C000602152:pinocarvone; C010789:beta-pinene
keywords: Cedronella canariensis var. canariensis; Lamiaceae; antioxidant; cytotoxicity; essential oil