title: pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery.
abstract: A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is reported. The fabrication of drug-loaded MPN capsules, which is based on the formation of coordination complexes between natural polyphenols and metal ions over a drug-coated template, represents a rapid strategy to engineer robust and versatile drug delivery carriers.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano, Science and Technologyand Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ping
authors.forename: Junling
authors.initials: J
authors.lastname: Guo
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ejima
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Richardson
authors.forename: Huanli
authors.initials: H
authors.lastname: Sun
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002214:Capsules / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D011992:Endosomes / Q000378:metabolism; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D019800:Phenol / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002214:Capsules; D004337:Drug Carriers; D008670:Metals; D011108:Polymers; D059808:Polyphenols; D019800:Phenol; D004317:Doxorubicin
keywords: chemotherapeutics; controlled release; coordination complexes; hybrid organic-inorganic materials; stimuli-responsive; templated assembly