title: Auxin transporters and binding proteins at a glance.
abstract: The plant hormone auxin is a key regulator of plant growth and development. Differences in auxin distribution within tissues are mediated by the polar auxin transport machinery, and cellular auxin responses occur depending on changes in cellular auxin levels. Multiple receptor systems at the cell surface and in the interior operate to sense and interpret fluctuations in auxin distribution that occur during plant development. Until now, three proteins or protein complexes that can bind auxin have been identified. SCF(TIR1) [a SKP1-cullin-1-F-box complex that contains transport inhibitor response 1 (TIR1) as the F-box protein] and S-phase-kinase-associated protein 2 (SKP2) localize to the nucleus, whereas auxin-binding protein 1 (ABP1), predominantly associates with the endoplasmic reticulum and cell surface. In this Cell Science at a Glance article, we summarize recent discoveries in the field of auxin transport and signaling that have led to the identification of new components of these pathways, as well as their mutual interaction.
authors.affiliation: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB) and Department of Plant Biotechnology and Bioinformatics, Ghent University, BE-9052 Gent, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Grones
authors.affiliation: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB) and Department of Plant Biotechnology and Bioinformatics, Ghent University, BE-9052 Gent, Belgium Mendel Centre for Plant Genomics and Proteomics, Masaryk University, CEITEC MU, CZ-625 00 Brno, Czech Republic jiri.friml@ist.ac.at.
authors.forename: Jiří
authors.initials: J
authors.lastname: Friml
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001693:Biological Transport, Active / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D044783:F-Box Proteins / Q000235:genetics / Q000378:metabolism; D007210:Indoleacetic Acids / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D044783:F-Box Proteins; D007210:Indoleacetic Acids; D011956:Receptors, Cell Surface; C528951:SKP2A protein, Arabidopsis; C501405:TIR1 protein, Arabidopsis
keywords: Auxin; Signaling; Transporters