title: Bisphosphonate therapy in pediatric patients.
abstract: Although for many decades bisphosphonates were used for adult bone loss, bisphosphonate administration in pediatric patients is new and was initiated in the past 15-year. The indications for pediatric bisphosphonates was extended to childhood malignancies with bone involvement, after additional effects were unveiled for bisphosphonates with recent research. In this article we review childhood bone loss and conditions with bone involvement in which bisphosphonate therapy have been used. We also review mechanisms of action of bisphosphonates, and present indications of bisphosphonate therapy in pediatric patients based on results of clinical trials.
authors.affiliation: Affiliate Professor of Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran ; Affiliate Faculty of University College of Omran and Tosseh, Hamedan, Iran.
authors.forename: Guiti
authors.initials: G
authors.lastname: Eghbali-Fatourechi
keywords: Bisphosphonate; Corticoid-induced osteoporosis; Nitrogen-containing bisphosphonate; Osteogenesis imperfecta; Pediatric bone loss; Pediatric bone malignancy; Pediatric osteoporosis