title: Thiazole: a promising heterocycle for the development of potent CNS active agents.
abstract: Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of biological activities. Thiazole and its derivatives have attracted continuing interest to design various novel CNS active agents. In the past few decades, thiazoles have been widely used to develop a variety of therapeutic agents against numerous CNS targets. Thiazole containing drug molecules are currently being used in treatment of various CNS disorders and a number of thiazole derivatives are also presently in clinical trials. A lot of research has been carried out on thiazole and their analogues, which has proved their efficacy to overcome several CNS disorders in rodent as well as primate models. The aim of present review is to highlights diverse CNS activities displayed by thiazole and their derivatives. SAR of this nucleus has also been well discussed. This review covers the recent updates present in literature and will surely provide a greater insight for the designing and development of potent thiazole based CNS active agents in future.
authors.affiliation: Bio-Organic Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, India.
authors.forename: Chandra Bhushan
authors.initials: CB
authors.lastname: Mishra
authors.affiliation: Bio-Organic Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Kumari
authors.affiliation: Bio-Organic Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, India. Electronic address: mtiwari07@gmail.com.
authors.forename: Manisha
authors.initials: M
authors.lastname: Tiwari
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D002491:Central Nervous System Agents; D006571:Heterocyclic Compounds; D013844:Thiazoles
keywords: CNS active agents; Heterocycle; Neurological disorders; Thiazole