title: Oxidised phospholipids as biomarkers in human disease.
abstract: Oxidised phospholipids (OxPLs) are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety of biological effects on diverse cell types in vitro and in vivo and are thought to play a role in the development of several chronic diseases including atherosclerosis, a classical lipid-associated and inflammatory disorder. OxPLs are recognised as culprit molecular components responsible for the pathophysiological actions of oxidised low-density lipoproteins. There is growing interest in the potential use of OxPLs as biomarkers of human pathologies. Here we offer a brief overview of current detection methods and knowledge on relationships between levels of circulating OxPLs and disease progression, with particular emphasis on cardiovascular disease.
authors.affiliation: Department of Biomedicine, Laboratory for Signal Transduction, University Hospital Basel, University of Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: Philippova
authors.affiliation: Department of Biomedicine, Laboratory for Signal Transduction, University Hospital Basel, University of Basel, Switzerland.
authors.forename: Therese
authors.initials: T
authors.lastname: Resink
authors.affiliation: Hirslanden Klinik St. Anna, Luzern, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Erne
authors.affiliation: Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University Graz, Austria.
authors.forename: Valery
authors.initials: V
authors.lastname: Bochkov
mesh_terms: D000818:Animals; D016633:Apolipoprotein A-II / Q000378:metabolism; D050197:Atherosclerosis / Q000503:physiopathology*; D015415:Biomarkers; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000503:physiopathology; D023903:Coronary Restenosis / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D020404:Glycerophospholipids / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D024821:Metabolic Syndrome / Q000503:physiopathology; D009422:Nervous System Diseases / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D051437:Renal Insufficiency / Q000503:physiopathology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C115794:APOA2 protein, human; D016633:Apolipoprotein A-II; D015415:Biomarkers; D020404:Glycerophospholipids; D008077:Lipoproteins, LDL