title: Serum gamma-glutamyl transferase is associated with the elevated uric acid levels in normotensive Chinese adults.
abstract: BACKGROUND
  Although both serum gamma-glutamyltransferase (GGT) and uric acid are correlated with hypertension, studies on the association between serum GGT and uric acid in normotensive individuals are rare. In this study, we tried to reveal this relationship in normotensive Chinese adults.
  
  
  METHODS
  Four hundred seven normotensive adults were recruited. The subjects were divided into 3 subgroups according to serum GGT tertiles. Anthropometric parameters as well as systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid, GGT, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose, blood lipids, and fasting insulin were measured. Insulin resistance was assessed using HOMA-IR index.
  
  
  RESULTS
  Uric acid was increased in parallel with increasing serum GGT (P<0.001). After correction for age, sex, smoking and alcohol consumption, serum GGT was positively associated with uric acid (r=0.42, P<0.001), SBP (r=0.22, P<0.001), and DBP (r=0.19, P<0.001). When compared with lowest GGT tertile, the odds ratio of the middle tertile for the increased serum uric acid was 3.43 (95% CI, 1.39-8.47) and 7.29 (95% CI, 1.57-33.82) for the highest tertile after adjustment for age, sex, BMI, smoking, alcohol consumption, SBP, DBP, creatinine and HOMA-IR.
  
  
  CONCLUSIONS
  Serum GGT is strongly associated with the increased uric acid concentrations in normotensive Chinese adults.
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China. Electronic address: zhangjx023@163.com.
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China.
authors.forename: Guang-Da
authors.initials: GD
authors.lastname: Xiang
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood* / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000378:metabolism
chemical_list: D014527:Uric Acid; D005723:gamma-Glutamyltransferase
keywords: Cardiovascular disease; Gamma-glutamyl transferase; Normotensive; Uric acid