title: Hypocoprins A-C: new sesquiterpenoids from the coprophilous fungus Hypocopra rostrata.
abstract: Studies of the coprophilous fungus Hypocopra rostrata (TTI-0009, NRRL 66178) isolated from a sample of horse dung collected in Texas led to the isolation of three new sesquiterpenoids that we named hypocoprins A-C (1-3), together with the known fungal metabolite helvolic acid. The new metabolites have a distinctive ring system consisting of fused cyclopropane and cyclodecene units not previously reported from a fungal source. Compounds 1 and 3 moderately inhibited growth of Staphylococcus aureus. The structures of these metabolites were assigned mainly by analysis of 2D NMR and HRESITOFMS data. Relative and absolute configurations were assigned by interpretation of NMR J-values and NOESY data and by application of Mosher's method. These results represent the first report of chemistry from any strain of the genus Hypocopra.
authors.affiliation: †Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.
authors.forename: Dinith R
authors.initials: DR
authors.lastname: Jayanetti
authors.affiliation: ‡Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1881 East Road, Houston, Texas 77054, United States.
authors.forename: Qun
authors.initials: Q
authors.lastname: Yue
authors.affiliation: ‡Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1881 East Road, Houston, Texas 77054, United States.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Bills
authors.affiliation: †Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D005672:Fusidic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification; D006736:Horses; D008372:Manure / Q000382:microbiology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000187:drug effects; D013781:Texas; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D008372:Manure; D012717:Sesquiterpenes; C000598669:hypocoprin A; C000598670:hypocoprin B; C000598671:hypocoprin C; D005672:Fusidic Acid; C011267:helvolic acid