title: Determinants of eosinophil survival and apoptotic cell death.
abstract: Eosinophils (Eos) are potent inflammatory cells and abundantly present in the sputum and lung of patients with allergic asthma. During both transit to and residence in the lung, Eos contact prosurvival cytokines, particularly IL-3, IL-5 and GM-CSF, that attenuate cell death. Cytokine signaling modulates the expression and function of a number of intracellular pro- and anti-apoptotic molecules. Both intrinsic mitochondrial and extrinsic receptor-mediated pathways are affected. This article discusses the fundamental role of the extracellular and intracellular molecules that initiate and control survival decisions by human Eos and highlights the role of the cis-trans isomerase, Pin1 in controlling these processes.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9072, USA, zhong.shen@utsouthwestern.edu.
authors.forename: Zhong-Jian
authors.initials: ZJ
authors.lastname: Shen
authors.forename: James S
authors.initials: JS
authors.lastname: Malter
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D002470:Cell Survival; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000502:physiology; D015398:Signal Transduction
chemical_list: D051017:Apoptosis Regulatory Proteins; D016207:Cytokines; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase