title: Transient sinus bradycardia during the course of Crimean-Congo hemorrhagic fever in children.
abstract: Crimean-Congo hemorrhagic fever (CCHF) is an acute tick-borne viral zoonotic disease which is endemic in Turkey. Bradycardia has been reported among pediatric and adult patients with CCHF. But, it remains unclear, whether bradycardia is associated with ribavirin treatment or the severity of CCHF. In this study 26 hospitalized CCHF patients were reviewed in terms of age, gender, history of tick bite, duration of hospitalization, presence of bradycardia, laboratory features, ribavirin treatment, and blood products requirement. The demographic, clinical, laboratory and treatment characteristics of CCHF patients with or without bradycardia were compared. The mean age of the patients was 126.42±48.21 months. There were 8 female and 18 male patients. Sinus bradycardia was noted in 15 patients (mean age was 120.20±50.59 months, 5 female). Ribavirin had been administered 18 (69.2%) patients and 11 of them had bradycardia. There was not statistically significant relationships between bradycardia and ribavirin treatment (p=0.683). Furthermore the occurrence of bradycardia was not associated with disease severity according to Swanepoel severity criteria (p=0.683). We concluded that independent of the disease severity and the ribavirin treatment, transient sinus bradycardia might occur during the clinical course of CCHF in pediatric patients. For this reason clinicians should be aware of this finding and all CCHF patients should be monitored closely.
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: zggayretli@gmail.com.
authors.forename: Zeynep Gokce
authors.initials: ZG
authors.lastname: Gayretli Aydin
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: gonultanir58@yahoo.com.
authors.forename: Gonul
authors.initials: G
authors.lastname: Tanir
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: drozgemetin@gmail.com.
authors.forename: Ozge
authors.initials: O
authors.lastname: Metin
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: turkanteke@gmail.com.
authors.forename: Turkan
authors.initials: T
authors.lastname: Aydin Teke
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: gibayhan@gmail.com.
authors.forename: Gulsum Iclal
authors.initials: GI
authors.lastname: Bayhan
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Pediatrics, Division of Infectious Diseases, Ankara, Turkey. Electronic address: drnuroz@gmail.com.
authors.forename: Fatma Nur
authors.initials: FN
authors.lastname: Oz
authors.affiliation: Virology Reference and Research Laboratory, Department of Microbiology Reference Laboratories, Public Health Institute of Turkey, 06100 Ankara, Turkey. Electronic address: dilekyagci@gmail.com.
authors.forename: Dilek Yagci
authors.initials: DY
authors.lastname: Caglayik
authors.affiliation: Ankara University Faculty of Medicine, Department of Biostatistics, 06100 Sıhhiye/Ankara, Turkey. Electronic address: zeynep.biyikli@gmail.com.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Gençtürk
mesh_terms: D000818:Animals; D001919:Bradycardia / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D012254:Ribavirin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D064927:Tick Bites; D014421:Turkey / Q000453:epidemiology
chemical_list: D012254:Ribavirin
keywords: Bradycardia; Children; Crimean-Congo hemorrhagic fever; Ribavirin; Tick-borne diseases