title: Dynamic functional connectivity using state-based dynamic community structure: method and application to opioid analgesia.
abstract: We present a new method, State-based Dynamic Community Structure, that detects time-dependent community structure in networks of brain regions. Most analyses of functional connectivity assume that network behavior is static in time, or differs between task conditions with known timing. Our goal is to determine whether brain network topology remains stationary over time, or if changes in network organization occur at unknown time points. Changes in network organization may be related to shifts in neurological state, such as those associated with learning, drug uptake or experimental conditions. Using a hidden Markov stochastic blockmodel, we define a time-dependent community structure. We apply this approach to data from a functional magnetic resonance imaging experiment examining how contextual factors influence drug-induced analgesia. Results reveal that networks involved in pain, working memory, and emotion show distinct profiles of time-varying connectivity.
authors.affiliation: Department Epidemiology and Biostatistics, Drexel University, 3215 Market St, Philadelphia, PA 19104, USA. Electronic address: lucy.f.robinson@drexel.edu.
authors.forename: Lucy F
authors.initials: LF
authors.lastname: Robinson
authors.affiliation: Department of Psychology, New York University, 6 Washington Place, New York, NY 10003, USA.
authors.forename: Lauren Y
authors.initials: LY
authors.lastname: Atlas
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado, Boulder, Muenzinger D244, 345 UCB, Boulder, CO 80309, USA.
authors.forename: Tor D
authors.initials: TD
authors.lastname: Wager
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008390:Markov Chains; D008959:Models, Neurological; D009434:Neural Pathways / Q000187:drug effects* / Q000502:physiology
chemical_list: D000701:Analgesics, Opioid
keywords: Functional connectivity; fMRI