title: Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases.
abstract: Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in proteins leads to failure of proteostasis (or vice versa) due to increased levels of unfolded, misfolded or aggregated proteins and, in turn, to aging and/or age-related diseases. The major cellular proteolytic machineries, namely the proteasome and the lysosome, have been shown to dysfunction during aging and age-related diseases. Regarding the proteasome, it is well established that it can be activated either through genetic manipulation or through treatment with natural or chemical compounds that eventually result to extension of lifespan or deceleration of the progression of age-related diseases. This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity. Moreover, it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes.
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece. Electronic address: nikichon@eie.gr.
authors.forename: Niki
authors.initials: N
authors.lastname: Chondrogianni
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Voutetakis
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Marianna
authors.initials: M
authors.lastname: Kapetanou
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Delitsikou
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Papaevgeniou
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece; Örebro University, Medical School, Örebro, Sweden.
authors.forename: Marianthi
authors.initials: M
authors.lastname: Sakellari
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Lefaki
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Filippopoulou
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece; Örebro University, Medical School, Örebro, Sweden. Electronic address: sgonos@eie.gr.
authors.forename: Efstathios S
authors.initials: ES
authors.lastname: Gonos
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics*; D000818:Animals; D005853:Geriatrics; D006801:Humans; D008136:Longevity / Q000235:genetics; D009422:Nervous System Diseases / Q000188:drug therapy / Q000235:genetics; D046988:Proteasome Endopeptidase Complex / Q000235:genetics* / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D046988:Proteasome Endopeptidase Complex
keywords: Age-related diseases; Aging; Longevity; Proteasome activation; Senescence; Ubiquitin–proteasome system