title: Hippocampal diffusion tensor imaging microstructural changes in vascular dementia.
abstract: To explore microstructural integrity of hippocampus in vascular dementia (VD) using DTI. Twenty-five individuals with VD, without magnetic resonance imaging (MRI) evidence of gray matter pathology, and 25 matched healthy control (HC) individuals underwent a 3T MRI protocol including T2, FLAIR, and PD in the axial plane, 3D whole-brain T1-weighted with an isotropic resolution of 1 mm, and DTI acquired using 64 diffusion sensitizing directions, b value of 1,500 s/mm(2), 65 axial slices, isotropic resolution of 1.8 mm. Images were processed to obtain indices of microstructural variations of bilateral hippocampi. Mean diffusivity (MD) in the hippocampus of patients with VD was significantly increased (p < 0.05) bilaterally with respect to that of the group of HC examinees. In VD group left hippocampal MD (10(-6 )× mm(2)/s) was 833.4 ± 92.8; in HC group left MD was 699.8 ± 56. In VD group, right hippocampal MD was 859.1 ± 69.8; in HC group right MD was 730.4 ± 40.2. No group differences were found in hippocampal FA. DTI shows microstructural hippocampal damage in VD in patients with normal appearing gray matter structures on conventional MRI, indicating the need for further research on the link between VD and AD.
authors.affiliation: Center of Radiology, Clinical Center of Vojvodina, School of Medicine, University of Novi Sad, 1-7 Hajduk Veljkova Street, 21000, Novi Sad, Serbia. jelenamarkovicostojic@gmail.com.
authors.forename: Jelena
authors.initials: J
authors.lastname: Ostojic
authors.affiliation: Diagnostic Imaging Center, Institute of Oncology, School of Medicine, University of Novi Sad, 4 Institutski put, 21204, Sremska Kamenica, Serbia. dusko.b.kozic@gmail.com.
authors.forename: Dusko
authors.initials: D
authors.lastname: Kozic
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, 6 Dr. Subotica Street, 11000, Belgrade, Serbia. aleksandrampavlovic2@gmail.com.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pavlovic
authors.affiliation: Clinic for Neurology, Clinical Center of Vojvodina, School of Medicine, University of Novi Sad, 1-7 Hajduk Veljkova Street, 21000, Novi Sad, Serbia. semnic@open.telekom.rs.
authors.forename: Marija
authors.initials: M
authors.lastname: Semnic
authors.affiliation: Diagnostic Imaging Center, Institute of Oncology, School of Medicine, University of Novi Sad, 4 Institutski put, 21204, Sremska Kamenica, Serbia. todorovicalleksandar@gmail.com.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Todorovic
authors.affiliation: Center of Radiology, Clinical Center of Vojvodina, School of Medicine, University of Novi Sad, 1-7 Hajduk Veljkova Street, 21000, Novi Sad, Serbia. smakap@gmail.com.
authors.forename: Kosta
authors.initials: K
authors.lastname: Petrovic
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, 6 Dr. Subotica Street, 11000, Belgrade, Serbia. nadezda.sternic@gmail.com.
authors.forename: Nadezda
authors.initials: N
authors.lastname: Covickovic-Sternic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016880:Anisotropy; D015140:Dementia, Vascular / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales
keywords: Diffusion tensor imaging; Hippocampus; Mean diffusivity; Vascular dementia