title: Endocan: a novel circulating proteoglycan.
abstract: Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan. It has the property of binding to a wide range of bioactive molecules associated with cellular signaling and adhesion and thus regulating proliferation, differentiation, migration, and adhesion of different cell types in health and disease. An increase in tissue expression or serum level of endocan reflects endothelial activation and neovascularization which are prominent pathophysiological changes associated with inflammation and tumor progression. Consequently, endocan has been used as a blood-based and tissue-based biomarker for various cancers and inflammation and has shown promising results.
authors.affiliation: Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
authors.forename: Arunava
authors.initials: A
authors.lastname: Kali
authors.affiliation: Department of Otorhinolaryngology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
authors.forename: K S Rathan
authors.initials: KS
authors.lastname: Shetty
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000737:chemistry / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D011379:Prognosis; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018805:Sepsis / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: Cancer; endocan; endothelial cell-specific molecule; proteoglycan