title: Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines.
abstract: Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
authors.affiliation: Department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China; Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Senthilkumar
authors.affiliation: Department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China; Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address: cba8888@hotmail.com.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
authors.affiliation: Department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China; Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D019684:Magnoliopsida / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Apoptosis; Leukemia; Multidrug resistance (MDR); Reversal multidrug resistance; Traditional medicinal plants