title: Expression and significance of glucosylceramide synthase in colorectal carcinoma tissues.
abstract: OBJECTIVE
  To investigate the impression of glucosylceramide synthase (GCS) in colorectal carcinoma tissues.
  
  
  METHODS
  Immunohistochemical method was used to detect the expression of GCS in 188 cases of colorectal carcinoma tissues and 80 cases of non-cancerous colorectal tissues. The expression of GCS and the relation with age, gender, tumor location, Tumor stage, differentiation, lymph node metastasis were analyzed. Thus, we further discussed whether to accept neoadjuvant chemotherapy can affect the expression of GCS.
  
  
  RESULTS
  GCS was overexpressed in colorectal carcinoma tissues compared with non-cancerous colorectal tissues; the expression of GCS was associated with lymph node metastasis, but not associated with age, gender, tumor location, differentiation and Tumor stage. What's more, the positive expression rate of GCS in patients who receiving neoadjuvant chemotherapy was higher than that in untreated patients.
  
  
  CONCLUSIONS
  GCS was upregulated in colorectal carcinoma tissues. It might not only play an important role in controlling the generation and progression of colorectal carcinoma, but also be a factor of MDR.
authors.affiliation: Department of Oncology, Yantai Yuhuangding Hospital, Affiliated to Qingdao University, Yantai, Shandong, China. believe.2007@aliyun.com.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: J N
authors.initials: JN
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: Y L
authors.initials: YL
authors.lastname: Mu
authors.forename: P
authors.initials: P
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005964:Glucosyltransferases / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D005964:Glucosyltransferases; C023246:ceramide glucosyltransferase