title: Apical transverse motion is associated with speckle-tracking radial dyssynchrony in patients with non-ischemic dilated cardiomyopathy.
abstract: OBJECTIVE
  Apical transverse motion (ATM) is a new parameter for assessing left ventricular (LV) dyssynchrony. Speckle-tracking radial strain analysis seems to be the best method to identify potential responders to cardiac resynchronization therapy. The aim of our study was to investigate the association between ATM and radial dyssynchrony assessed by speckle-tracking echocardiography in patients with non-ischemic dilated cardiomyopathy (NDC).
  
  
  METHODS
  We examined 35 NDC patients (mean age 49.2 ± 28.1 years; 21 males). Cardiac dimension and ejection fraction (EF) were measured. Speckle-tracking analysis was performed on two-dimensional greyscale images in the mid-LV short axis view and apical views to calculate global radial, circumferential, and longitudinal strain (GRS, GCS, GLS), as well as rotational indexes (LV twist and torsion). Radial dyssynchrony was defined as a difference in time to peak systolic radial strain between the anteroseptal and posterior segments with a cut-off value of 130 ms. ATM was estimated using motion traces of 2 opposite apical segments.
  
  
  RESULTS
  Radial dyssynchrony was significantly correlated with ATMloop (r = 0.78, p < 0.001), ATM4CV (r = 0.71, p = 0.001), ATM3CV (r = 0.67, p = 0.003), GRS (r = -0.51, p = 0.04), GCS (r = -0.55, p = 0.03), LV twist (r = -0.58, p = 0.02), and LV torsion (r = -0.56, p = 0.03). The receiver operating characteristics analysis for ATMloop to distinguish between patients with and without radial dyssynchrony revealed an area under the curve value of 0.88 (CI: 0.73-1.04, p = 0.005). The best cut-off value was 2.5 mm for ATMloop (85% sensitivity and 86% specificity).
  
  
  CONCLUSIONS
  Apical transverse motion is closely associated with radial dyssynchrony assessed by speckle-tracking echocardiography. Quantitative measure of apical rocking has the potential for clinical applications.
authors.affiliation: Department of Cardiology, Ordu State Hospital; Ordu-Turkey. emregurelctf@yahoo.com.
authors.forename: Emre
authors.initials: E
authors.lastname: Gürel
authors.forename: Kürşat
authors.initials: K
authors.lastname: Tigen
authors.forename: Tansu
authors.initials: T
authors.lastname: Karaahmet
authors.forename: Cihan
authors.initials: C
authors.lastname: Dündar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Güler
authors.forename: Yelda
authors.initials: Y
authors.lastname: Başaran
mesh_terms: D000328:Adult; D000368:Aged; D058406:Cardiac Resynchronization Therapy; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014102:Torsion Abnormality / Q000000981:diagnostic imaging*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D055815:Young Adult