title: [Impact of a targeted educational intervention on respiratory syncytial virus bronchiolitis prevention in full-term and preterm infants].
abstract: OBJECTIVE
  Palivizumab, a humanized monoclonal antibody directed against respiratory syncytial virus (RSV), is the only existent immunoprophylaxis therapy for prevention of serious lower respiratory tract disease caused by RSV in infants (up to 2 years of age), particularly in those who meet high-risk criteria (preterm infants and/or those with bronchopulmonary or congenital heart disease). In our region, the monthly injections are not given at the hospital but by private pediatricians during the epidemic season. We aimed to assess the influence of an educational and personalized support of preterm infants treated with Palivizumab on patient compliance during the last season.
  
  
  METHODS
  A three-level educational intervention was conducted: the parents were advised in the neonatology units, then at the hospital pharmacy where the treatment was delivered, and finally by their referent pediatrician. We evaluated the impact of this intervention by measuring patient compliance, defined by two criteria, and by measuring the rate of rehospitalization for RSV bronchiolitis. We compared these results to those of the previous season (2011-2012) in which no interventional program was conducted.
  
  
  RESULTS
  Compliance was better in the group of patients followed (2012-2013); 59.7% of them received all the palivizumab doses, while only 32.9% of the infants not followed received all doses. The number of injections given at appropriate intervals remained stable between the two groups and no significant difference was found in the rate of RSV bronchiolitis rehospitalizations.
  
  
  CONCLUSIONS
  This educational intervention program, coordinated by doctors and pharmacists, is associated with improved treatment compliance in high-risk of RSV bronchiolitis infants. To optimize such a care program, we have planned to set up and then evaluate a call center procedure involving extensive counseling for parents and reminder telephone calls.
authors.affiliation: Pôle pharmacie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France. Electronic address: l_bernard@chu-clermontferrand.fr.
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.affiliation: Pôle pédiatrie, pharmacie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Lecomte
authors.affiliation: DRCI, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Pereira
authors.affiliation: Pôle pharmacie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Proux
authors.affiliation: Pôle pharmacie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Boyer
authors.affiliation: Pôle pharmacie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: V
authors.initials: V
authors.lastname: Sautou
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000517:prevention & control* / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D008297:Male; D055118:Medication Adherence; D000069455:Palivizumab / Q000627:therapeutic use*; D010290:Parents; D010353:Patient Education as Topic; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control*; D012189:Retrospective Studies; D047929:Term Birth
chemical_list: D000998:Antiviral Agents; D000069455:Palivizumab