title: Lack of influence of an XRCC3 gene polymorphism on oral cancer susceptibility: meta-analysis.
abstract: BACKGROUND
  To systematically summarize the association between the X-ray repair cross complementing 3 (XRCC3) gene polymorphism and oral cancer susceptibility by meta-analysis.
  
  
  METHODS
  Databases including PubMed, EMbase, CNKI, VIP and WanFang Data were searched to identify case-control studies concerning the association between an XRCC3 gene polymorphism and the risk of oral cancer from the inception to June 2014. Two reviewers independently screened the literature according to the criteria, extracted the data and assessed the quality. Then meta-analysis was performed using Stata 11.0 software.
  
  
  RESULTS
  Seven published case-control studies including 775 patients with oral cancer and 1922 controls were selected. Associations between the rs861539 polymorphism and overall oral cancer risk were not statistically significant in all kinds of comparison models (CT vs CC: OR=0.94, 95%CI=0.74-1.18; TT vs CC: OR=0.94, 95%CI=0.64- 1.38; dominant model: OR=0.95, 95%CI=0.76-1.18; recessive model: OR=0.94, 95%CI=0.69-1.29; allele T vs C: OR=0.97, 95%CI=0.84-1.11). In the stratified analysis by ethnicity, no significant associations were found among Asians and Caucasians. On stratification by tumor type, no significant associations were found for cancer and oral premalignant lesions.
  
  
  CONCLUSIONS
  The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. Considering the limited quality of the included case-control studies, more high quality studies with large sample size are needed to verify the above conclusion.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, Shenyang, China E-mail : luli@mail.cmu.edu.cn.
authors.forename: En-Jiao
authors.initials: EJ
authors.lastname: Zhang
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Cui
authors.forename: Zhong-Fei
authors.initials: ZF
authors.lastname: Xu
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Duan
authors.forename: Shao-Hui
authors.initials: SH
authors.lastname: Huang
authors.forename: Xue-Xin
authors.initials: XX
authors.lastname: Tan
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Yin
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Lu
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3