title: Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor.
abstract: Here, we present a precision cancer nanomedicine based on Bi(2)S(3) nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi(2)S(3) NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi(2)S(3) NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Zheng
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.forename: Liangjun
authors.initials: L
authors.lastname: Zhou
authors.forename: Gan
authors.initials: G
authors.lastname: Tian
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Hu
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001729:Bismuth / Q000737:chemistry*; D045744:Cell Line, Tumor; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D051379:Mice; D064847:Multimodal Imaging; D043942:Nanotubes; D061088:Photoacoustic Techniques; D010789:Phototherapy; D013440:Sulfides / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D013440:Sulfides; D001729:Bismuth; C049897:bismuth sulfide
keywords: Bi2S3 nanorods; X-ray computed tomography; multispectral optoacoustic tomography; photothermal therapy; thin bandgap semiconductor