title: Nasopharyngeal airway stenting devices for obstructive sleep apnoea: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To systematically review outcomes of adults with obstructive sleep apnoea treated with nasopharyngeal airway stenting devices.
  
  
  METHODS
  Medline, Scopus, Web of Science and the Cochrane Library databases were searched, and data on device use and tolerability, sleepiness, oxygen saturation, apnoea index, apnoea-hypopnoea index, and sleep quality were collected.
  
  
  RESULTS
  Of 573 potential studies, 29 were retrieved for detailed evaluation and 16 met the study criteria. Polysomnography data for patients treated with nasal trumpets as an isolated therapy were pooled for meta-analysis. The mean apnoea index ± standard deviation, for 53 patients, decreased from 32.4 ± 15.9 to 9.0 ± 7.2 episodes per hour (p < 0.00001). The mean apnoea-hypopnoea index, for 193 patients, decreased from 44.1 ± 18.9 to 22.7 ± 19.3 episodes per hour (p < 0.00001). The mean lowest oxygen saturation, for 193 patients, increased from 66.5 ± 14.2 to 75.5 ± 13.9 per cent (p < 0.00001).
  
  
  CONCLUSIONS
  Some studies have demonstrated limited effectiveness and low tolerability of nasopharyngeal airway stenting devices, while other studies have shown a significant benefit in treating obstructive sleep apnoea, with a high level of patient acceptance. Nasal trumpets have been successful in decreasing airway obstruction in the short term.
authors.affiliation: Stanford University School of Medicine,California,USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Kumar
authors.affiliation: Department of Psychiatry,Sleep Medicine Division,Stanford Hospital and Clinics,Redwood City,California,USA.
authors.forename: C
authors.initials: C
authors.lastname: Guilleminault
authors.affiliation: Department of Otorhinolaryngology,Hospital Sao Sebastiao, Santa Maria da Feira,Portugal.
authors.forename: V
authors.initials: V
authors.lastname: Certal
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Sleep Surgery Division,Stanford University Medical Center,California,USA.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Sleep Surgery Division,Stanford University Medical Center,California,USA.
authors.forename: R
authors.initials: R
authors.lastname: Capasso
authors.affiliation: Department of Psychiatry,Sleep Medicine Division,Stanford Hospital and Clinics,Redwood City,California,USA.
authors.forename: M
authors.initials: M
authors.lastname: Camacho
mesh_terms: D058109:Airway Management / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D009305:Nasopharynx; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000628:therapy*; D015607:Stents; D016896:Treatment Outcome
keywords: Therapeutics