title: Tigecycline : a critical safety review.
abstract: BACKGROUND
  The emergence of multidrug-resistant (MDR) infections has been extensively observed worldwide and has become a priority issue over past decade. Tigecycline , a broad spectrum antibiotic covering against many MDR organisms, has been widely used. However, recent meta-analysis studies have raised a concern for its efficacy and safety. Reviewing tigecycline safety data would enhance the appropriate use of this medication.
  
  
  METHODS
  This article reviews the safety profile of tigecycline, including its side effects and drug interactions.
  
  
  CONCLUSIONS
  The increased mortality associated with tigecycline is not yet well understood. Based on current evidence, alternative options must be prioritized over tigecycline if available. When tigecycline use is warranted, vigilant observation to identify any breakthrough infections and careful monitoring of progression of the original infection are highly recommended. Considering a second agent (either for synergism or enhancing coverage) may be required.
authors.affiliation: University of Texas Health Science Center at Houston, Division of Infectious Diseases , 6431 Fannin Street, MSB 2.112, Houston, TX 77030 , USA +1 713 500 6733 ; +1 713 500 5495 ; quanhathai.kaewpoowat@uth.tmc.edu.
authors.forename: Quanhathai
authors.initials: Q
authors.lastname: Kaewpoowat
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D008911:Minocycline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: adverse reactions; drugs interactions; safety evaluation; tigecycline