title: Two new lignans from Saururus chinensis and their DGAT inhibitory activity.
abstract: Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3±1.5 to 87.5±1.3μM.
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Tuo
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
authors.forename: Shi-Zhou
authors.initials: SZ
authors.lastname: Qi
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Xing
authors.affiliation: Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 685-1 Yangcheongri, Ochangeup, Cheongwongun, Chungbuk 363-883, Republic of Korea.
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China. Electronic address: cuilong71@beihua.edu.cn.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
mesh_terms: D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D057809:HEK293 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D032134:Saururaceae / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D017705:Lignans; D051048:Diacylglycerol O-Acyltransferase
keywords: DGAT; Lignan; Saururaceae; Saururus chinensis