title: Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice.
abstract: Fucoidan (FCD) is a well-known bioactive constituent of seaweed extract that possess a wide spectrum of activities in biological systems, including anti-cancer, anti-inflammation and modulation of immune systems. However, evidence on the effects of FCD on exercise performance and physical fatigue is limited. Therefore, we investigated the potential beneficial effects of FCD on ergogenic and anti-fatigue functions following physiological challenge. Male ICR mice from three groups (n = 8 per group) were orally administered FCD for 21 days at 0, 310 and 620 mg/kg/day, which were, respectively, designated the vehicle, FCD-1X and FCD-2X groups. The results indicated that the FCD supplementations increased the grip strength (p = 0.0002) and endurance swimming time (p = 0.0195) in a dose-depend manner. FCD treatments also produced dose-dependent decreases in serum levels of lactate (p < 0.0001) and ammonia (p = 0.0025), and also an increase in glucose level (p < 0.0001) after the 15-min swimming test. In addition, FCD supplementation had few subchronic toxic effects. Therefore, we suggest that long-term supplementation with FCD can have a wide spectrum of bioactivities on health promotion, performance improvement and anti-fatigue.
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. yschiu12369@yahoo.com.tw.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. 1020209@ntsu.edu.tw.
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Tsai
authors.affiliation: Department of Food Science, Fu Jen Catholic University, Taipei 24205, Taiwan. tytsai@mail.fju.edu.tw.
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Tsai
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. yschiu12369@yahoo.com.tw.
authors.forename: Yen-Shuo
authors.initials: YS
authors.lastname: Chiu
authors.affiliation: Department of Neurosurgery, Taipei Medical University-WanFang Hospital, Taipei City 11696, Taiwan. nsweili@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wei
authors.affiliation: Center for General Education, Chang Gung University of Science and Technology, Taoyuan 33301, Taiwan. wcchen@gw.cgust.edu.tw.
authors.forename: Wen-Chyuan
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. john5523@ntsu.edu.tw.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000641:Ammonia / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D019587:Dietary Supplements; D005221:Fatigue / Q000517:prevention & control*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018482:Muscle, Skeletal / Q000187:drug effects; D000459:Phaeophyceae / Q000737:chemistry; D010805:Physical Conditioning, Animal; D011134:Polysaccharides / Q000008:administration & dosage*; D059550:Toxicity Tests, Subchronic
chemical_list: D001786:Blood Glucose; D011134:Polysaccharides; D019344:Lactic Acid; D000641:Ammonia; C007789:fucoidan; D003402:Creatine Kinase