title: The interaction between medical burden and anticholinergic cognitive burden on neuropsychological function in a geriatric primary care sample.
abstract: Poorer neuropsychological function is associated with increased medical burden (MB) and the use of more anticholinergic medications. However, the interaction between MB and anticholinergic cognitive burden (AB) on neuropsychological performance is unknown. In a sample of 290 elderly primary care patients, those with a greater level of AB demonstrated poorer Total Index performance on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Further, an interaction effect was noted such that there was a greater anticholinergic effect on RBANS Total, Attention, and Delayed Memory Index scores for participants with fewer MB. Participants with more MB demonstrated poorer performance irrespective of their level of AB. These results indicate that MB effects may be overshadowed by anticholinergic effects in older patients.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA.
authors.forename: Cady K
authors.initials: CK
authors.lastname: Block
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Logue
authors.affiliation: UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095-1759, USA.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Thaler
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Scarisbrick
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Mahoney
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA jim-scott@ouhsc.edu.
authors.forename: James
authors.initials: J
authors.lastname: Scott
authors.affiliation: The University of Utah, Salt Lake City, UT 84108, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Duff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D000066492:Cognitive Aging; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009483:Neuropsychological Tests; D011320:Primary Health Care; D011795:Surveys and Questionnaires
chemical_list: D018680:Cholinergic Antagonists
keywords: Assessment; Attention; Geriatrics