title: Why pulsatility still matters: a review of current knowledge.
abstract: Continuous-flow left ventricular assist devices (LVAD) have become standard therapy option for patients with advanced heart failure. They offer several advantages over previously used pulsatile-flow LVADs, including improved durability, less surgical trauma, higher energy efficiency, and lower thrombogenicity. These benefits translate into better survival, lower frequency of adverse events, improved quality of life, and higher functional capacity of patients. However, mounting evidence shows unanticipated consequences of continuous-flow support, such as acquired aortic valve insufficiency and acquired von Willebrand syndrome. In this review article we discuss current evidence on differences between continuous and pulsatile mechanical circulatory support, with a focus on clinical implications and potential benefits of pulsatile flow.
authors.affiliation: Davor Barić, Department of Cardiac Surgery and Transplantation, Dubrava University Hospital, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia, dbaric@kbd.hr.
authors.forename: Davor
authors.initials: D
authors.lastname: Barić
mesh_terms: D006333:Heart Failure / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D011673:Pulsatile Flow; D011788:Quality of Life