title: Akt1 rs2498801 is related to survival in head and neck squamous cell cancer treated with radiotherapy.
abstract: BACKGROUND
  Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered.
  
  
  METHODS
  Data relating to Akt1 single nucleotide polymorphism (SNP) and response to treatment of 46 patients treated with exclusive RT or RT-CT for HNSCC were evaluated.
  
  
  RESULTS
  For heterozygous patients median overall survival was 28.5 months, while for the wild-type group median overall survival was 10.9 (p=0.019). Three-year survival was 85% for mutated Akt1 homozygosis and 40% for patients with a heterozygous status (p=0.019, hazard ratio (HR)=7.960).
  
  
  CONCLUSIONS
  SNP of rs2498804 can recognize patients resistant to RT-CT. Further studies are needed to confirm our data and to investigate the role of Akt SNPs in HNSCC patients.
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy francep24@hotmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pasqualetti
authors.affiliation: Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Bocci
authors.affiliation: Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Mey
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Menghini
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Montrone
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Cocuzza
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ferrazza
authors.affiliation: 1st Ear Nose Throat Unit, University Hospital of Pisa, Pisa, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Seccia
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Durim
authors.initials: D
authors.lastname: Delishaj
authors.affiliation: Department Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Orlandini
authors.affiliation: Division of Radiotherapy, Department Of Oncology, University Hospital of Pisa, Pisa, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Fabrini
authors.affiliation: Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Romano
authors.initials: R
authors.lastname: Danesi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt
keywords: AKT; chemotherapy; head neck; radiotherapy