title: Maternal perinatal undernutrition modifies lactose and serotranferrin in milk: relevance to the programming of metabolic diseases?
abstract: A close link between intrauterine growth restriction and development of chronic adult diseases such as obesity, diabetes, and hypertension has been established both in humans and animals. Modification of growth velocity during the early postnatal period (i.e., lactation) may also sensitize to the development of metabolic syndrome in adulthood. This suggests that milk composition may have long-lasting programming/deprogramming metabolic effects in the offspring. We therefore assess the effects of maternal perinatal denutrition on breast milk composition in a food-restricted 50% (FR50) rat model. Monosaccharides and fatty acids were characterized by gas chromatography, and proteins were profiled by surface-enhanced laser desorption/ionization-time-of-flight analysis in milk samples from FR50 and control rat dams. Milk analysis of FR50 rats demonstrated that maternal undernutrition decreases lactose concentration and modulates lipid profile at postnatal day 10 by increasing the unsaturated fatty acids/saturated fatty acids and diminishes serotransferrin levels at postnatal day 21. Our data indicate that maternal perinatal undernutrition modifies milk composition both quantitatively and qualitatively. These modifications by maternal nutrition open new perspectives to identify molecules that could be used in artificial milk to protect from the subsequent development of metabolic diseases.
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France;
authors.forename: J S
authors.initials: JS
authors.lastname: Wattez
authors.affiliation: Unité de Glycobiologie Structurale et Fonctionnelle (UMR8576), Université de Lille, Villeneuve d'Ascq, France;
authors.forename: A
authors.initials: A
authors.lastname: Delmont
authors.affiliation: Inserm U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France;
authors.forename: M
authors.initials: M
authors.lastname: Bouvet
authors.affiliation: Inserm U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France;
authors.forename: O
authors.initials: O
authors.lastname: Beseme
authors.affiliation: Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany; and.
authors.forename: S
authors.initials: S
authors.lastname: Goers
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France;
authors.forename: F
authors.initials: F
authors.lastname: Delahaye
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France;
authors.forename: C
authors.initials: C
authors.lastname: Laborie
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France;
authors.forename: J
authors.initials: J
authors.lastname: Lesage
authors.affiliation: Lactic Acid Bacteria & Mucosal Immunity (U1019-UMR8204), Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Foligné
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France;
authors.forename: C
authors.initials: C
authors.lastname: Breton
authors.affiliation: Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany; and.
authors.forename: C C
authors.initials: CC
authors.lastname: Metges
authors.affiliation: Environnement Périnatal et Croissance (EA4489), Université Lille-Nord de France, Equipe Dénutritions Maternelles Périnatales, Université de Lille, Villeneuve d'Ascq, France; didier.vieau@univ-lille1.fr.
authors.forename: D
authors.initials: D
authors.lastname: Vieau
authors.affiliation: Inserm U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France;
authors.forename: F
authors.initials: F
authors.lastname: Pinet
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D005260:Female; D007774:Lactation / Q000378:metabolism; D007785:Lactose / Q000378:metabolism*; D008297:Male; D044342:Malnutrition / Q000378:metabolism*; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000209:etiology*; D008892:Milk / Q000378:metabolism*; D036801:Parturition / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism*
chemical_list: D014168:Transferrin; D007785:Lactose
keywords: carbohydrates; fatty acids; mass spectrometry; nutrition; rat