title: [Urgent changes in the expression of hypoxia-inducible factor-1α (HIF-1α) in the neocortex of rats with different tolerance to acute hypoxia underwent focal ischemic stroke prefrontal cortex].
abstract: Using immunohistochemical method, it was demonstrated that neurons of the cerebral cortex have the capacity to express hypoxia-inducible factor-1 alpha (HIF-1α) in normoxia. Intensity of this process is different for rats having unequal tolerance to hypoxia. Basal HIF-1α expression in neurons of rats with low-resistance (LR) to hypoxia is higher compared to rats with high-resistance (HR). Bilateral photochemically induced focal ischemic insult in the rat prefrontal cortex completely suppressed HIF-1α neuronal expression the in the ischemic zone and only partially--in the area of the penumbra. Neuronal injury was more pronounced in cortex of LR rats compared to HR rats. These findings suggest that functional significance of HIF-1α is greater in neurons of the cerebral cortex of LR rats compared to HR rats.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Kirova
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
authors.forename: E L
authors.initials: EL
authors.lastname: Germanova
authors.forename: A A
authors.initials: AA
authors.lastname: Paltsyn
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: Ye A
authors.initials: YA
authors.lastname: Rybnikova
authors.forename: L D
authors.initials: LD
authors.lastname: Lukyanova
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D019579:Neocortex / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D009928:Organ Specificity; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D020521:Stroke / Q000378:metabolism*
chemical_list: C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit