title: "You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology.
abstract: Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.
authors.affiliation: Professor of Human Toxicology, Department of Toxicology, Maastricht University, The Netherlands.
authors.forename: Aalt
authors.initials: A
authors.lastname: Bast
authors.affiliation: Associate Professor at the University College Roosevelt, Middelburg, The Netherlands; Adjunct at the University of Massachusetts Amherst, Environmental Health Sciences.
authors.forename: Jaap C
authors.initials: JC
authors.lastname: Hanekamp
keywords: Golden Ratio; LNT; adaption; reification fallacy