title: Plant pathogenic bacteria target the actin microfilament network involved in the trafficking of disease defense components.
abstract: Cells of infected organisms transport disease defense-related molecules along actin filaments to deliver them to their sites of action to combat the pathogen. To accommodate higher demand for intracellular traffic, plant F-actin density increases transiently during infection or treatment of Arabidopsis with pathogen-associated molecules. Many animal and plant pathogens interfere with actin polymerization and depolymerization to avoid immune responses. Pseudomonas syringae, a plant extracellular pathogen, injects HopW1 effector into host cells to disrupt the actin cytoskeleton and reduce vesicle movement in order to elude defense responses. In some Arabidopsis accessions, however, HopW1 is recognized and causes resistance via an actin-independent mechanism. HopW1 targets isoform 7 of vegetative actin (ACT7) that is regulated by phytohormones and environmental factors. We hypothesize that dynamic changes of ACT7 filaments are involved in plant immunity.
authors.affiliation: a Department of Molecular Genetics and Cell Biology ; The University of Chicago ; Chicago , IL USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jelenska
authors.forename: Yongsung
authors.initials: Y
authors.lastname: Kang
authors.forename: Jean T
authors.initials: JT
authors.lastname: Greenberg
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D001426:Bacterial Proteins; D010935:Plant Diseases; D057865:Plant Immunity / Q000502:physiology*; D021381:Protein Transport; D044224:Pseudomonas syringae
chemical_list: D000199:Actins; D001426:Bacterial Proteins
keywords: Actin; HopW1; Pseudomonas syringae; arabidopsis; effector; plant immunity; type III secretion; vesicle traffic