title: Changes in bone density after cancer treatment in patients with cervical and endometrial cancer.
abstract: OBJECTIVE
  This study aimed to evaluate the impact of cancer treatment on bone mineral density (BMD) in the lumbar spine (LS) and femur in the postmenopausal women with cervical or endometrial cancer without bone metastasis compared to normal control postmenopausal women.
  
  
  METHODS
  We retrospectively evaluated the BMD data in the LS, femur neck (FN) and trochanter (FT) by dual-energy X-ray absorptiometry and laboratory data of bone turnover markers at baseline and after one year in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls.
  
  
  RESULTS
  There were no significant differences in the T-scores of basal BMD in LS and femur between patients with endometrial cancer and controls, and only T-score of basal BMD at the fourth lumbar vertebra (L4) was significantly lower in patients with cervical cancer compared to controls. One year later, T-scores of BMD at all LS sites and FN in patients with cervical cancer and T-scores of BMD at L3, L4, FN, and FT in those with endometrial cancer after cancer treatment were significantly lower compared to controls. Lower proportions of normal BMD at all skeletal sites except L2 in patients with endometrial cancer and those at L1, L4, and FN in patients with cervical cancer were observed compared to controls after cancer treatment.
  
  
  CONCLUSIONS
  Our results suggest that cancer treatment increase bone loss in postmenopausal women with cervical and endometrial cancer.
authors.affiliation: 1. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea;
authors.forename: Young Lim
authors.initials: YL
authors.lastname: Oh
authors.affiliation: 2. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea;
authors.forename: Man Soo
authors.initials: MS
authors.lastname: Yoon
authors.affiliation: 2. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea;
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Suh
authors.affiliation: 3. Department of Obstetrics and Gynecology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea;
authors.forename: Ari
authors.initials: A
authors.lastname: Kim
authors.affiliation: 4. Department of Obstetrics and Gynecology, Catholic University School of Medicine, Seoul, Republic of Korea;
authors.forename: Min Joung
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: 5. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea;
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: 6. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Republic of Korea;
authors.forename: Yong Jung
authors.initials: YJ
authors.lastname: Song
authors.affiliation: 7. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Republic of Korea.
authors.forename: Yong Il
authors.initials: YI
authors.lastname: Ji
authors.affiliation: 2. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea;
authors.forename: Ki Hyung
authors.initials: KH
authors.lastname: Kim
authors.affiliation: 7. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Republic of Korea.
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chun
keywords: Bone mineral density; Cervical cancer; Endometrial cancer; Osteoporosis.