title: Electrodeposited silk coatings for bone implants.
abstract: The aim of this study was to characterize the mechanical properties and drug elution features of silk protein-based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1% to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible, and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment.
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155.
authors.forename: Roberto
authors.initials: R
authors.lastname: Elia
authors.affiliation: School of Dental Medicine, Tufts University, Boston, Massachusetts, 02111.
authors.forename: Courtney D
authors.initials: CD
authors.lastname: Michelson
authors.affiliation: School of Dental Medicine, Tufts University, Boston, Massachusetts, 02111.
authors.forename: Austin L
authors.initials: AL
authors.lastname: Perera
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155.|Department of Maxilo-Facial Surgery University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany, 81675.
authors.forename: Teresa F
authors.initials: TF
authors.lastname: Brunner
authors.affiliation: School of Dental Medicine, Tufts University, Boston, Massachusetts, 02111.
authors.forename: Masly
authors.initials: M
authors.lastname: Harsono
authors.affiliation: Department of Mechanical Engineering, Tufts University, Medford, Massachusetts, 02155.
authors.forename: Gray G
authors.initials: GG
authors.lastname: Leisk
authors.affiliation: School of Dental Medicine, Tufts University, Boston, Massachusetts, 02111.
authors.forename: Gerard
authors.initials: G
authors.lastname: Kugel
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155.
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
mesh_terms: D018786:Bone Substitutes / Q000737:chemistry*; D055664:Electrochemical Techniques; D008422:Materials Testing; D019736:Prostheses and Implants; D047011:Silk / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D047011:Silk
keywords: bioactive coating; dental implant coating; electrodeposition; electrogelation