title: [Acquired angioedema].
abstract: Acquired angioedema are rare. They are associated with monoclonal gammapathies of uncertain significance (MGUS) or lymphomas. They give the same symptoms as the hereditary form and the same laryngeal risk. They are characterized by a low level of C4, C1Inh and C1q. They are linked to the consumption of C1Inh by the lymphoid cells or to the presence of anti-C1Inh autoantibodies. They must be treated by symptomatic treatment when attack occur (C1Inh concentrate and icatibant). The use of rituximab needs to prove its efficiency.
authors.affiliation: AP-HP, DHU i2B, université Paris 6, hôpital Saint-Antoine, centre de références des angioedèmes à kinines (CREAK), service de médecine interne, 75012 Paris, France. Electronic address: olivier.fain@sat.aphp.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
authors.affiliation: AP-HP, DHU i2B, université Paris 6, hôpital Saint-Antoine, centre de références des angioedèmes à kinines (CREAK), service de médecine interne, 75012 Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Gobert
authors.affiliation: AP-HP, DHU i2B, université Paris 6, hôpital Saint-Antoine, centre de références des angioedèmes à kinines (CREAK), service de médecine interne, 75012 Paris, France.
authors.forename: Cam Anh
authors.initials: CA
authors.lastname: Khau
authors.affiliation: AP-HP, DHU i2B, université Paris 6, hôpital Saint-Antoine, centre de références des angioedèmes à kinines (CREAK), service de médecine interne, 75012 Paris, France.
authors.forename: Arsène
authors.initials: A
authors.lastname: Mekinian
authors.affiliation: AP-HP, université Paris 7, urgences, hôpital Louis-Mounier, 92700 Colombes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Javaud
mesh_terms: D000799:Angioedema / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D001920:Bradykinin / Q000009:adverse effects; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy
chemical_list: D001920:Bradykinin