title: Partial laryngeal surgery in recurrent carcinoma.
abstract: With the growing acceptance of nonsurgical therapies for laryngeal squamous cell carcinomas (LSCCs), it has become important to delineate surgical salvage strategies for disease recurrences. Total laryngectomy is often recommended, but appropriately selected laryngeal recurrences may be treated successfully with partial laryngeal surgery: laryngeal function can be preserved with oncological efficacy. The main available studies dealing with partial laryngeal surgery in recurrent carcinoma were critically reviewed. The most appealing feature of salvage transoral laser surgery (TLS) is the opportunity to make tumor-tailored excisions without any reconstructive limitations and retaining the option to switch to open partial laryngectomy. A recent detailed review of 11 series found a pooled local control rate of 57% after a first TLS procedure. Supracricoid laryngectomy (SCL) seems to achieve good local control rates in selected cases of recurrent supraglottic-glottic carcinoma: one review considering seven series calculated that 85% of the patients treated with salvage SCL after radiotherapy experienced no local recurrence; and total laryngectomy after failure of salvage SCL afforded an overall local control rate of 65%. Neck dissection is mandatory in all cases of local LSCC recurrence with evidence of neck metastases, and routine elective neck dissection is recommended for recurrent supraglottic and transglottic cancers.
authors.affiliation: Department of Neurosciences, Otolaryngology Section, University of Padova , Padova , Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
authors.forename: Rosario
authors.initials: R
authors.lastname: Marchese-Ragona
authors.forename: Norbert H
authors.initials: NH
authors.lastname: Kleinsasser
authors.forename: Marco
authors.initials: M
authors.lastname: Lionello
authors.forename: Georges
authors.initials: G
authors.lastname: Lawson
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hagen
authors.forename: Alberto
authors.initials: A
authors.lastname: Staffieri
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D053685:Laser Therapy; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D016879:Salvage Therapy
keywords: Laryngeal carcinoma; neck dissection; partial laryngectomy; recurrence; salvage surgery; supracricoid laryngectomy; transoral laser surgery