title: Cannabis use in relation to obesity and insulin resistance in the Inuit population.
abstract: OBJECTIVE
  To ascertain the relationship between cannabis use, obesity, and insulin resistance.
  
  
  METHODS
  Data on 786 Inuit adults from the Nunavik Inuit Health Survey (2004) were analyzed. Information on cannabis use was obtained from a self-completed, confidential questionnaire. Fasting blood glucose and insulin and homeostasis model assessment of insulin resistance (HOMA-IR) served as surrogate markers of insulin resistance. Analysis of covariance and multivariate logistic regression ascertained relationships between cannabis use and outcomes.
  
  
  RESULTS
  Cannabis use was highly prevalent in the study population (57.4%) and was statistically associated with lower body mass index (BMI) (P < 0.001), lower % fat mass (P < 0.001), lower fasting insulin (P = 0.04), and lower HOMA-IR (P = 0.01), after adjusting for numerous confounding variables. Further adjustment for BMI rendered fasting insulin and HOMA-IR differences statistically nonsignificant between past-year cannabis users and nonusers. Mediation analysis showed that the effect of cannabis use on insulin resistance was indirect, through BMI. In multivariate analysis, past-year cannabis use was associated with 0.56 lower likelihood of obesity (95% confidence interval 0.37-0.84).
  
  
  CONCLUSIONS
  Cannabis use was associated with lower BMI, and such an association did not occur through the glucose metabolic process or related inflammatory markers. The association between cannabis use and insulin resistance was mediated through its influence on weight.
authors.affiliation: Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Québec, Canada.
authors.forename: Gerard
authors.initials: G
authors.lastname: Ngueta
authors.forename: Richard E
authors.initials: RE
authors.lastname: Bélanger
authors.forename: Elhadji A
authors.initials: EA
authors.lastname: Laouan-Sidi
authors.forename: Michel
authors.initials: M
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002188:Cannabis; D055030:Drug Users; D005260:Female; D006306:Health Surveys; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000208:ethnology* / Q000502:physiology*; D004930:Inuit; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology* / Q000503:physiopathology*; D015995:Prevalence; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin