title: Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): association with clinical severity and phenotype.
abstract: To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181 children with aAEDS and 93 healthy children were evaluated. According to the skin-prick test (SPT) for allergens and serum total IgE, all patients were subdivided in two groups: 104 aAEDS and 77 naAEDS. In all patients, serum IL-17, IL-23, and IL-10 levels were detected. Serum IL-17 and IL-23 levels were significantly higher, and serum IL-10 levels were significantly lower in AEDS children than healthy group (p < 0.001). Moreover, serum IL-17 and IL-23 levels were significantly higher in aAEDS than in naAEDS subtypes (p < 0.001). Differently, serum IL-10 levels resulted similar in both subtypes. There was a correlation between Score Atopic Dermatitis (SCORAD) index and both IL-17 and IL-23 and an inverse correlation between SCORAD index and IL-10 in aAEDS and naAEDS types. Serum IL-17 and IL-23 values were positively related to total IgE levels (p < 0.0001) in aAEDS. Further increase of IL-17 and IL-23 levels was detected in aAEDS subjects with atopic diseases such as asthma and rhinitis than children with only allergic sensitization. Our study confirms the role of IL-17, IL-23, and IL-10 and their relationship with the severity of AEDS. We firstly found a correlation between high IL-17/IL-23 axis levels and different phenotypes of AEDS in children, suggesting its role as marker of "atopic march" and disease severity.
authors.affiliation: Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Leonardi
authors.forename: Caterina
authors.initials: C
authors.lastname: Cuppari
authors.forename: Sara
authors.initials: S
authors.lastname: Manti
authors.forename: Martina
authors.initials: M
authors.lastname: Filippelli
authors.forename: Giuseppe Fabio
authors.initials: GF
authors.lastname: Parisi
authors.forename: Francesco
authors.initials: F
authors.lastname: Borgia
authors.forename: Silvana
authors.initials: S
authors.lastname: Briuglia
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cannavò
authors.forename: Annamaria
authors.initials: A
authors.lastname: Salpietro
authors.forename: Teresa
authors.initials: T
authors.lastname: Arrigo
authors.forename: Carmelo
authors.initials: C
authors.lastname: Salpietro
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D016753:Interleukin-10 / Q000097:blood*; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D010641:Phenotype; D012720:Severity of Illness Index; D013577:Syndrome
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D016753:Interleukin-10; D007073:Immunoglobulin E