title: Expression of vascular endothelial growth factor C and anti-angiogenesis therapy in endometriosis.
abstract: Angiogenesis is an important pathogenesis of Endometriosis. Vascular endothelial growth factor C (VEGF-C) is one of the most important factor in the regulation of both normal and abnormal angiogenesis. Anti-angiogenic treatment of endometriosis is still in the exploratory stage. In this study, we investigate the relationship between VEGF-C and endometriosis, the therapeutic effects of Endostar in the rat endometriosis model. We then demonstrated that Immunohistochemical expression of VEGF-C was higher in endometriotic tissues than in control normal ovary tissues (P < 0.01) and higher in the endomertriosis grade III-IV than in endomertriosis grade I-II (P=0.013). In rat endometriosis model, we observed a significant reduction in the mean volume and weight of the endometriotic implants per rat in the treatment group as compared with the control group. By immunohistochemical evaluation, there was a significant reduction in VEGF-C expression after treatment in all areas examined. VEGF-C may be involved in the pathogenesis of endomertriosis by regulating the angiogenesis. Endostar has therapeutic effects of endometriosis lesions in the rat endometriosis model.
authors.affiliation: Medical College of Soochow University Shanghai 215123, P. R. China ; Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Hou
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Guang-Xu
authors.initials: GX
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: You-Hua
authors.initials: YH
authors.lastname: Sheng
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University Shanghai 200011, P. R. China.
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Cheng
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus Shanghai 201499, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D004715:Endometriosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D043169:Endostatins / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011994:Recombinant Proteins; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*; D055815:Young Adult
chemical_list: D043169:Endostatins; D011994:Recombinant Proteins; D042582:Vascular Endothelial Growth Factor C; C522911:endostar protein
keywords: Endomertriosis; Endostar; VEGF-C; angiogenesis; rat