title: A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus.
abstract: OBJECTIVE
  Appropriate treatment of patients with Type 1 diabetes mellitus (T1DM) is necessary to avoid further complications. This study was performed to compare the efficacy of insulin Glargine and Aspart with NPH insulin and regular insulin regimen in a group of children with T1DM.
  
  
  METHODS
  Forty patients with T1DM were enrolled in this study. During run-in, all subjects were treated with conventional therapy consisting of twice-daily NPH and thrice-daily regular. Following randomization, 20 subjects received Glargine and Aspart and 20 subjects received NPH and Regular insulin.
  
  
  RESULTS
  Mean HbA1c was 8.8% and 8.6% at first and 8.4% and 8.2% at the end of study for subjects randomized initially to Glargine and Aspart and for those randomized to NPH and Regular, respectively (P>0.05). Mean fasting blood glucose (FBS) of the subjects randomized initially to Glargine and Aspart was 217±101 mg/dL, with no significant difference to 196±75 mg/dL for those randomized to NPH and Regular (P=0.48). This was also true at the end of the study. The difference in total cholesterol and triglyceride between the two groups in the beginning of study and at the end did not show any significance.
  
  
  CONCLUSIONS
  The current study showed no significant difference in glycemic control [Glycated hemoglobin (HbA1c) and FBS] and lipid profile (total cholesterol and triglyceride) between two regimes.
authors.affiliation: Department of Pediatrics;
authors.forename: Parastoo
authors.initials: P
authors.lastname: Rostami
authors.affiliation: Department of Pediatrics;
authors.forename: Aria
authors.initials: A
authors.lastname: Setoodeh
authors.affiliation: Department of Pediatrics; ; Growth and Development Research Center;
authors.forename: Ali
authors.initials: A
authors.lastname: Rabbani
authors.affiliation: Department of Pediatrics;
authors.forename: Maryam
authors.initials: M
authors.lastname: Nakhaei-Moghadam
authors.affiliation: Research Center for Immunodeficiencies, Children's Medical Center;
authors.forename: Farnaz
authors.initials: F
authors.lastname: Najmi-Varzaneh
authors.affiliation: Research Center for Immunodeficiencies, Children's Medical Center; ; Department of Immunology, Molecular Immunology Research Center, School of Medicine; Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
keywords: Conventional Therapy; Insulin Aspart; Insulin Glargine; Type 1 Diabetes Mellitus