title: Tenascin-C in cardiovascular remodeling: potential impact for diagnosis, prognosis estimation and targeted therapy.
abstract: Fetal variants of tenascin-C are not expressed in healthy adult myocardium. But, there is a relevant re-occurrence during pathologic cardiac tissue and vascular remodeling. Thus, these molecules, in particular B and C domain containing tenascin-C, might qualify as promising novel biomarkers for diagnosis and prognosis estimation. Since a stable extracellular deposition of fetal tenascin-C variants is present in diseased cardiac tissue, the molecules are excellent target structures for antibody-based delivery of diagnostic (e.g., radionuclides) or therapeutic (bioactive payloads) agents directly to the site of disease. Against the background that fetal tenascin-C variants are functionally involved in cardiovascular tissue remodeling, therapeutic functional blocking strategies could be experimentally tested in the future.
authors.affiliation: a Department of Internal Medicine I; Jena University Hospital ; Jena , Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Franz
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
authors.forename: Alexander
authors.initials: A
authors.lastname: Lauten
authors.forename: Hans R
authors.initials: HR
authors.lastname: Figulla
authors.forename: Alexander
authors.initials: A
authors.lastname: Berndt
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D019063:Tenascin / Q000378:metabolism*; D066253:Vascular Remodeling / Q000187:drug effects*
chemical_list: D005353:Fibronectins; D019063:Tenascin
keywords: cardiovascular diseases; diagnosis; prognosis; tenascin-C; therapy