title: Synthesis of highly functionalized tri- and tetrasubstituted alkenes via Pd-catalyzed 1,2-hydrovinylation of terminal 1,3-dienes.
abstract: An efficient method for the construction of Csp(2)-Csp(3) bond in a regio- and stereoselective fashion involving 1,3-terminal dienes, enol triflates/nonaflates, and sodium formate under Pd(0)-catalysis is described. The three component assembly allows trapping of a π-allyl intermediate, after the initial migratory insertion of the diene, by a hydride source that leads to structurally complex and synthetically challenging tri- and tetrasubstituted alkene building blocks.
authors.affiliation: Department of Chemistry, University of Utah , 315 South 1400 East, Salt Lake City, Utah 84112-0085, United States.
authors.forename: Vaneet
authors.initials: V
authors.lastname: Saini
authors.forename: Mark
authors.initials: M
authors.lastname: O'Dair
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D005030:Ethylenes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011090:Polyenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D005030:Ethylenes; D011090:Polyenes; D010165:Palladium; C036216:ethylene