title: Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China.
abstract: OBJECTIVE
  Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chinese patients with mild-to-moderate AD.
  
  
  METHODS
  In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination.
  
  
  RESULTS
  No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two.
  
  
  CONCLUSIONS
  Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD.
authors.affiliation: Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Neurosurgery Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Medicine, University of New South Wales, Kensington, N.S.W., Australia.
authors.forename: Ya Ruth
authors.initials: YR
authors.lastname: Huo
authors.affiliation: Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Neurosurgery Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Neurosurgery Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Change
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Neurosurgery Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China ; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
keywords: APOE; Alzheimer's disease; CYP2D6; Chinese population; Donepezil; Polymorphism