title: Are semen parameters related to birth weight?
abstract: Several experimental models suggest a link between maternal nutrition during gestation and reproductive function in offspring, but the impact of birth weight on male fertility in adulthood in humans is poorly documented. To study whether birth weight is associated with unexplained male subfertility later in life, we evaluated the relationship between birth weight and sperm parameters in adulthood in white subfertile men, partners of couples with primary idiopathic subfertility, and fertile men recruited within the ALIFERT (Diet and Its Relationship with Couple Infertility) study. Total sperm count, progressive motility, and sperm DNA fragmentation were analyzed in sperm, and metabolic assays were performed on blood. Birth weight was associated with sperm DNA fragmentation and inversely correlated with total sperm count, underlining the importance of the in utero environment for male reproductive function.
  
  
  BACKGROUND
  NCT01093378.
authors.affiliation: Reproductive Biology Unit, Centre d'Étude et de Conservation des Oeufs et du Sperme, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France; Nutritional Epidemiology Unit, Unité de Recerche en Epidmiologie Nutritionnelle (UREN), U1125, Unités Mixtes de Recherche (UMR), U557, Institut National Scientifique d'Etudes et de Recherches Médicales, Institut National de Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM), Centre de Recherche en Nutrition Humaine Ile de France), Sorbonne Paris Cité, Paris 13 University, Bobigny, France. Electronic address: c.faure@uren.smbh.univ-paris13.fr.
authors.forename: Céline
authors.initials: C
authors.lastname: Faure
authors.affiliation: Reproductive Biology Unit, Centre d'Étude et de Conservation des Oeufs et du Sperme, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France; Nutritional Epidemiology Unit, Unité de Recerche en Epidmiologie Nutritionnelle (UREN), U1125, Unités Mixtes de Recherche (UMR), U557, Institut National Scientifique d'Etudes et de Recherches Médicales, Institut National de Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM), Centre de Recherche en Nutrition Humaine Ile de France), Sorbonne Paris Cité, Paris 13 University, Bobigny, France; INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy en Josas, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dupont
authors.affiliation: INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy en Josas, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Chavatte-Palmer
authors.affiliation: Translational Research Institute, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Benoit
authors.initials: B
authors.lastname: Gautier
authors.affiliation: Reproductive Biology Unit, Centre d'Étude et de Conservation des Oeufs et du Sperme, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France; Nutritional Epidemiology Unit, Unité de Recerche en Epidmiologie Nutritionnelle (UREN), U1125, Unités Mixtes de Recherche (UMR), U557, Institut National Scientifique d'Etudes et de Recherches Médicales, Institut National de Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM), Centre de Recherche en Nutrition Humaine Ile de France), Sorbonne Paris Cité, Paris 13 University, Bobigny, France.
authors.forename: Rachel
authors.initials: R
authors.lastname: Levy
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D001724:Birth Weight / Q000502:physiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D055101:Semen Analysis / Q000706:statistics & numerical data*; D012680:Sensitivity and Specificity; D013094:Spermatozoa / Q000473:pathology*; D013223:Statistics as Topic; D055815:Young Adult
keywords: Birth weigh; DOHAD; fertility; sperm quality; total sperm count