title: Role of silver nanoparticles (AgNPs) on the cardiovascular system.
abstract: With the advent of nanotechnology, the use and applications of silver nanoparticles (AgNPs) have increased, both in consumer products as well as in medical devices. However, little is known about the effects of these nanoparticles on human health, more specific in the cardiovascular system, since this system represents an important route of action in terms of distribution, bioaccumulation and bioavailability of the different circulating substances in the bloodstream. A collection of studies have addressed the effects and applications of different kinds of AgNPs (shaped, sized, coated and functionalized) in several components of the cardiovascular system, such as endothelial cells, isolated vessels and organs as well as integrative animal models, trying to identify the underlying mechanisms involved in their actions, to understand their implication in the field of biomedicine. The purpose of the present review is to summarize the most relevant studies to date of AgNPs effects in the cardiovascular system and provide a broader picture of the potential toxic effects and exposure risks, which in turn will allow pointing out the directions of further research as well as new applications of these versatile nanomaterials.
authors.affiliation: Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico. cgonzalez.uaslp@gmail.com.|Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, USA. cgonzalez.uaslp@gmail.com.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gonzalez
authors.affiliation: Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico.
authors.forename: Hector
authors.initials: H
authors.lastname: Rosas-Hernandez
authors.affiliation: Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico.
authors.forename: Manuel Alejandro
authors.initials: MA
authors.lastname: Ramirez-Lee
authors.affiliation: Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico.
authors.forename: Samuel
authors.initials: S
authors.lastname: Salazar-García
authors.affiliation: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, USA.
authors.forename: Syed F
authors.initials: SF
authors.lastname: Ali
mesh_terms: D001808:Blood Vessels / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000009:adverse effects / Q000633:toxicity*; D012834:Silver / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D014018:Tissue Distribution
chemical_list: D012834:Silver
keywords: Blood vessels; Cardiovascular system; Endothelium; Silver nanoparticles; Toxicity