title: Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control.
abstract: There is increasing evidence that the complement system plays an important role in diabetes and the development of diabetic vascular complications. In particular, mannan-binding lectin (MBL) levels are elevated in diabetes patients, and diabetes patients with diabetic nephropathy have higher MBL levels than diabetes patients with normal renal function. The MBL-associated serine proteases (MASPs) MASP-1, MASP-2 and MASP-3 and MBL-associated protein MAp44 have not yet been studied in diabetes patients. We therefore measured plasma levels of MASP-1, MASP-2, MASP-3 and MAp44 in 30 children with type 1 diabetes mellitus (T1DM) and 17 matched control subjects, and in 45 adults with T1DM and 31 matched control subjects. MASP-1 and MASP-2 levels were significantly higher in children and adults with T1DM than in their respective control groups, whereas MASP-3 and MAp44 levels did not differ between patients and controls. MASP-1 and MASP-2 levels correlated with HbA1c, and MASP levels decreased when glycaemic control improved. Because MASP-1 and MASP-2 have been shown to interact directly with blood coagulation, elevated levels of these proteins may play a role in the enhanced thrombotic environment and consequent vascular complications in diabetes.
authors.affiliation: University Clinic of Haematology, Haemostasis Research Laboratory, University Hospital of Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Jenny
authors.forename: R
authors.initials: R
authors.lastname: Ajjan
authors.forename: R
authors.initials: R
authors.lastname: King
authors.forename: S
authors.initials: S
authors.lastname: Thiel
authors.forename: V
authors.initials: V
authors.lastname: Schroeder
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000276:immunology; D005260:Female; D006442:Glycated Hemoglobin / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008297:Male; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000276:immunology* / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000276:immunology
chemical_list: D006442:Glycated Hemoglobin; D050606:Mannose-Binding Protein-Associated Serine Proteases; C517652:hemoglobin A1c protein, human; C084067:MASP1 protein, human; C105296:MASP2 protein, human
keywords: MASP-1; MASP-2; diabetes; mannan-binding lectin-associated serine proteases