title: [Thrombolysis with plasminogen activators: use and research of serine proteinases, promise and actuality].
abstract: Physiological plasminogen activators of tissue and urokinase type (serine proteinases) are effective thrombolytic agents. Research and development of their novel forms contributed to progress of thrombolytic therapy, advanced treatment of acute coronary syndrome and a marked decrease in the lethal index.
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex.
authors.forename: A V
authors.initials: AV
authors.lastname: Maksimenko
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D006801:Humans; D010958:Plasminogen / Q000378:metabolism; D010960:Plasminogen Activators / Q000138:chemical synthesis / Q000627:therapeutic use*; D016019:Survival Analysis; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D014568:Urokinase-Type Plasminogen Activator / Q000138:chemical synthesis / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010958:Plasminogen; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator
keywords: acute coronary syndrome; reperfusion; serine proteinases; thrombolysis; thrombosis; tissue and urokinase type plasminogen activators