title: Concise synthesis of the C15-C38 fragment of okadaic acid: application of the Suzuki-Miyaura reaction to spiroacetal synthesis.
abstract: A concise synthetic entry to the C15-C38 fragment of okadaic acid by exploiting a Suzuki-Miyaura reaction for the rapid assembly of the spiroacetal substructures has been developed. The present synthesis was completed in 19 linear steps from a commercially available material, showcasing the efficiency of our synthetic strategy.
authors.affiliation: Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Keita
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Muto
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D002247:Carbon Isotopes / Q000737:chemistry; D015394:Molecular Structure; D019319:Okadaic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000080:Acetals; D002247:Carbon Isotopes; D013141:Spiro Compounds; D019319:Okadaic Acid