title: Design of stable β-hairpin mimetics through backbone disulfide bonds.
abstract: The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue, their thiol exchange, and proteolytic stability are investigated. The results suggest that thiostatines can be used to design proteolytically stable water-soluble β-hairpin mimetics without deviating from overall β-hairpin conformation.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Mothukuri
authors.initials: M
authors.lastname: Ganesh Kumar
authors.forename: Sachitanand M
authors.initials: SM
authors.lastname: Mali
authors.forename: K Muruga Poopathi
authors.initials: KM
authors.lastname: Raja
authors.forename: Hosahudya N
authors.initials: HN
authors.lastname: Gopi
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D006860:Hydrogen Bonding; D007704:Kininogens / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary
chemical_list: D000596:Amino Acids; D004220:Disulfides; D007704:Kininogens; D010455:Peptides; D003545:Cysteine