title: Endocrine abnormalities of patients with cleft lip and/or cleft palate during the neonatal period.
abstract: OBJECTIVE
  There are close interactions among the developing oral cavity, pituitary gland, and central nervous system (CNS) in early embryonic life. In this study we aimed to screen endocrine abnormalities in patients with orofacial clefts in the neonatal period.
  
  
  METHODS
  Thirty-one patients with isolated orofacial median clefts wereincluded in the study. Pituitary, thyroid, and adrenal hormones were measured at the first week and remeasured in the third or fourth weeks. Imaging studies were done for detection of CNS anomalies in all patients.
  
  
  RESULTS
  Endocrine abnormality was detected in 22 (70.9%) patients. The number of patients with single and multiple endocrine abnormalities were 13 (41.9%) and 9 (29%), respectively. Thyroid hormone-related disorders were detected in 10 (32.3%) patients. Growth hormone deficiency was detected in 4 (12.9%) patients. Adrenocorticotrophic hormone and/or glucocorticoid deficiency was detected in 5 (16.1%) patients. Neonatal hypoglycemia due to endocrinological abnormalities was detected in 6 (19.4%) patients. Defected mini-puberty was seen in 2 (15.4%) patients. There was no relationship between the types of orofacial cleft and endocrine abnormalities.
  
  
  CONCLUSIONS
  Endocrinological evaluation of the patients with orofacial clefts in the neonatal period is a worthwhile endeavor to detect hormone deficiencies regardless of the type of the cleft.
authors.affiliation: Department of Pediatrics, Erciyes University, Kayseri, Turkey. mustafaaliakin@hotmail.com
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akin
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
authors.forename: Dilek
authors.initials: D
authors.lastname: Sarici
authors.forename: Leyla
authors.initials: L
authors.lastname: Akin
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Levent
authors.initials: L
authors.lastname: Korkmaz
authors.forename: Tamer
authors.initials: T
authors.lastname: Güneş
authors.forename: Mehmet Adnan
authors.initials: MA
authors.lastname: Oztürk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akçakuş
mesh_terms: D000015:Abnormalities, Multiple / Q000097:blood*; D000305:Adrenal Cortex Hormones / Q000097:blood*; D002971:Cleft Lip / Q000097:blood* / Q000150:complications; D002972:Cleft Palate / Q000097:blood* / Q000150:complications; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009421:Nervous System Malformations / Q000097:blood / Q000150:complications; D010907:Pituitary Hormones / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D000305:Adrenal Cortex Hormones; D010907:Pituitary Hormones; D013963:Thyroid Hormones