title: Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice.
abstract: Long-term exposure to stress or high glucocorticoid levels leads to depression-like behavior in rodents; however, the cause remains unknown. Increasing evidence shows that astrocytes, the most abundant cells in the central nervous system (CNS), are important to the nervous system. Astrocytes nourish and protect the neurons, and serve as glycogen repositories for the brain. The metabolic process of glycogen, which is closely linked to neuronal activity, can supply sufficient energy substrates for neurons. The research team probed into the effects of chronic corticosterone (CORT) exposure on the glycogen level of astrocytes in the hippocampal tissues of male C57BL/6N mice in this study. The results showed that chronic CORT injection reduced hippocampal neurofilament light protein (NF-L) and synaptophysin (SYP) levels, induced depression-like behavior in male mice, reduced hippocampal glycogen level and glycogen synthase activity, and increased glycogen phosphorylase activity. The results suggested that the reduction of the hippocampal glycogen level may be the mechanism by which chronic CORT treatment damages hippocampal neurons and induces depression-like behavior in male mice.
authors.affiliation: Laboratory of Pathological Sciences, Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Pathology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
authors.forename: Hui-yu
authors.initials: HY
authors.lastname: Zhang
authors.forename: Yu-nan
authors.initials: YN
authors.lastname: Zhao
authors.forename: Zhong-li
authors.initials: ZL
authors.lastname: Wang
authors.forename: Yu-fang
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000009:adverse effects* / Q000097:blood; D003863:Depression / Q000139:chemically induced*; D004195:Disease Models, Animal; D006003:Glycogen / Q000378:metabolism*; D024981:Glycogen Phosphorylase / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins; D016708:Synaptophysin; C044882:neurofilament protein L; D006003:Glycogen; D024981:Glycogen Phosphorylase; D006006:Glycogen Synthase; D003345:Corticosterone
keywords: Corticosterone; Depression; Glycogen; Hippocampus; Stress