title: The locus C11orf30 increases susceptibility to poly-sensitization.
abstract: A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK; MRC-PHE Centre for Environment & Health, London, UK.
authors.forename: A F S
authors.initials: AF
authors.lastname: Amaral
authors.forename: C
authors.initials: C
authors.lastname: Minelli
authors.forename: S
authors.initials: S
authors.lastname: Guerra
authors.forename: M
authors.initials: M
authors.lastname: Wjst
authors.forename: N
authors.initials: N
authors.lastname: Probst-Hensch
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: C
authors.initials: C
authors.lastname: Svanes
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.forename: J
authors.initials: J
authors.lastname: Heinrich
authors.forename: D L
authors.initials: DL
authors.lastname: Jarvis
mesh_terms: D000328:Adult; D000483:Alleles; D000485:Allergens / Q000276:immunology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006306:Health Surveys; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins / Q000235:genetics*; D012882:Skin Tests
chemical_list: D000485:Allergens; C480344:EMSY protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D007073:Immunoglobulin E
keywords: allergens; allergic sensitization; genes for atopy; poly-sensitization