title: Old and New Drugs for Treatment of Stable Angina: New Anti-Anginal Drugs and Coronary Revascularization.
abstract: Since the first human catheterization performed by Forssman in 1929 angioplasty equipment and medical therapies have undergone considerable evolution and technical improvement allowing interventionalists to perform more complex procedures and solving most of the percutaneous limitations. While percutaneous coronary intervention (PCI) has dramatically changed the outcome in the Acute Coronary Syndrome (ACS) setting, its role in the treatment of chronic stable angina is still debated. Stable coronary artery disease (SCAD) is a major public health issue and its prevalence is still increasing in the industrialized world. The correct treatment sees a multi-strategy approach aimed to a relief of symptoms, prevention of future cardiac events and survival improvement. In so forth, treatment strategies include optimal medical therapy (OMT) alone or combined with percutaneous or surgical coronary revascularization. Despite this, angina remains poorly controlled in the vast majority of CAD patients. Traditional agents such Beta-blockers or Calcium channel blockers or short and long acting nitrates have been used as first-line anti-anginal therapy for several years. Nowadays newer and more effective drugs usually used on top of older medical treatment have become available.
authors.forename: Gioel G
authors.initials: GG
authors.lastname: Secco
authors.forename: Rosario
authors.initials: R
authors.lastname: Parisi
authors.forename: Francesca
authors.initials: F
authors.lastname: Mirabella
authors.affiliation: Coronary Care Unit and Catheterization Laboratory "Maggiore della Carità" Hospital Corso Mazzini 18, 28100 Novara, Italy. arognoni@hotmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Rognoni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lupi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Luca
authors.forename: Paolo N
authors.initials: PN
authors.lastname: Marino
authors.forename: Rossella
authors.initials: R
authors.lastname: Fattori
authors.forename: Alberto
authors.initials: A
authors.lastname: Cremonesi
authors.forename: Fausto
authors.initials: F
authors.lastname: Castriota
mesh_terms: D060050:Angina, Stable / Q000188:drug therapy* / Q000601:surgery; D000818:Animals; D001552:Benzazepines / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006801:Humans; D000077550:Ivabradine; D020108:Nicorandil / Q000627:therapeutic use; D062645:Percutaneous Coronary Intervention; D000069458:Ranolazine / Q000627:therapeutic use; D014292:Trimetazidine / Q000627:therapeutic use
chemical_list: D001552:Benzazepines; D002317:Cardiovascular Agents; D020108:Nicorandil; D000077550:Ivabradine; D000069458:Ranolazine; D014292:Trimetazidine