title: 4D co-registration of X-ray and MR-mammograms: initial clinical results and potential incremental diagnostic value.
abstract: OBJECTIVE
  4D co-registration of X-ray- and MR-mammograms (XM and MM) is a new method of image fusion. The present study aims to evaluate its clinical feasibility, radiological accuracy, and potential clinical value.
  
  
  METHODS
  XM and MM of 25 patients were co-registered. Results were evaluated by a blinded reader.
  
  
  RESULTS
  Precision of the 4D co-registration was "very good" (mean-score [ms]=7), and lesions were "easier to delineate" (ms=5). In 88.8%, "relevant additional diagnostic information" was present, accounting for a more "confident diagnosis" in 76% (ms=5).
  
  
  CONCLUSIONS
  4D co-registration is feasible, accurate, and of potential clinical value.
authors.affiliation: Department of Neuroradiology, University of Erlangen-Nürnberg, Schwabachanlage 6, D-91054, Germany; Institute of Diagnostic and Interventional Radiology I, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany. Electronic address: dietzelmatthias2@hotmail.com.
authors.forename: Matthias
authors.initials: M
authors.lastname: Dietzel
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute for Data Processing and Electronics, Postfach 3640, D-76021 Karlsruhe, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Hopp
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute for Data Processing and Electronics, Postfach 3640, D-76021 Karlsruhe, Germany.
authors.forename: Nicole V
authors.initials: NV
authors.lastname: Ruiter
authors.affiliation: Institute of Diagnostic and Interventional Radiology I, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany; Karlsruhe Institute of Technology (KIT), Institute for Data Processing and Electronics, Postfach 3640, D-76021 Karlsruhe, Germany.
authors.forename: Clemens G
authors.initials: CG
authors.lastname: Kaiser
authors.affiliation: Institute of Diagnostic and Interventional Radiology I, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany.
authors.forename: Werner A
authors.initials: WA
authors.lastname: Kaiser
authors.affiliation: Institute of Diagnostic and Interventional Radiology I, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany; Institute of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim Jena, Germany; Department of Biomedical Imaging and Image-guided therapy, Vienna.
authors.forename: Pascal A
authors.initials: PA
authors.lastname: Baltzer
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*
keywords: Co-registration; Dynamic contrast enhanced MRI; Mammography; Multimodal diagnosis