title: [Significance of chromosome 7 abnormalities in myeloid malignancies].
abstract: Chromosome 7 abnormalities are the most common cytogenetic alterations found in myeloid malignancies. Myeloid malignancies exhibiting monosomy 7/del (7q) have been confirmed to associate with high susceptibility to infections, poor response to chemotherapy, and short survival time, so speculating that chromosome 7 has important tumor suppressor genes. Commonly deleted segments (such as 7q22) of chromosome 7 have been identified by FISH and other technologies. Genes (EZH2, MLL5, DOCK4, SAMD9L/SAMD9) located in commonly deleted segments of 7q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7/del(7q).
authors.affiliation: Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Shi
authors.affiliation: Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China. E-mail: lixiao3326@yahoo.com.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China.
authors.forename: Chun-Kang
authors.initials: CK
authors.lastname: Chang
mesh_terms: D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009196:Myeloproliferative Disorders