title: [Bronchial thermoplasty in the treatment of severe adult asthma].
abstract: Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma.
authors.affiliation: Inserm U1067 CNRS UMR 7333, service de pneumologie, AP-HM, Aix Marseille université, chemin des Bourrely, 13015 Marseille, France. Electronic address: pascal.chanez@univ-amu.fr.
authors.forename: P
authors.initials: P
authors.lastname: Chanez
authors.affiliation: Centre de recherche, institut de cardiologie et de pneumologie de l'université Laval Québec, Québec, Canada.
authors.forename: L-P
authors.initials: LP
authors.lastname: Boulet
authors.affiliation: Département de radiologie, AP-HP Avicenne, 93000 Bobigny, France.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Brillet
authors.affiliation: Département de pneumologie, CHU de Gand, université de Gand, Gand, Belgique.
authors.forename: G
authors.initials: G
authors.lastname: Joos
authors.affiliation: Centre de recherche, institut de cardiologie et de pneumologie de l'université Laval Québec, Québec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Laviolette
authors.affiliation: Département de pneumologie, CHU de Liège, GIGAI3 groupe de recherche, université de Liège, Liège, Belgique.
authors.forename: R
authors.initials: R
authors.lastname: Louis
authors.affiliation: Département de pneumologie, hôpitaux universitaires de Genève, Genève, Suisse.
authors.forename: T
authors.initials: T
authors.lastname: Rochat
authors.affiliation: Département de pneumologie, hôpitaux universitaires de Genève, Genève, Suisse.
authors.forename: P
authors.initials: P
authors.lastname: Soccal
authors.affiliation: U700 Inserm DHU, service de pneumologie, AP-HP Bichat, université Diderot Paris, 75018 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Aubier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology / Q000601:surgery*; D001980:Bronchi / Q000601:surgery*; D001999:Bronchoscopy / Q000009:adverse effects / Q000379:methods*; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods; D004564:Electrocoagulation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Asthma exacerbation; Asthma phenotypes; Asthme sévère; Bronchial endoscopy; Bronchial thermoplasty; Endoscopie bronchique; Exacerbation; Phénotypes de l’asthme; Severe asthma; Thermoplastie bronchique