title: Reflectance confocal microscopy for the diagnosis of vulvar naevi: six cases.
abstract: OBJECTIVE
  The differential diagnosis between vulvar naevi and melanoma is challenging. In vivo reflectance-mode confocal microscopy (RCM) is an emerging technique that allows non-invasive high-resolution imaging of the skin and mucosa. It has recently been used for the study of vulvar melanosis and melanoma, but it has not been so far employed for the diagnosis of genital naevi. The objective of this study is to evaluate RCM features of vulvar naevi and to compare them with dermoscopical and histopathological aspects.
  
  
  METHODS
  Clinical, dermoscopical, in vivo RCM and histological features of six vulvar naevi were evaluated.
  
  
  RESULTS
  The clinical and/or dermoscopical aspects were suspicious in all six cases. RCM showed a blue naevus, an atypical genital naevus, a junctional naevus and three compound naevi that were later confirmed by histological examination. In one compound naevus, RCM showed focal cytological atypia and architectural irregularity without clear features of malignancy, confirmed by histological examination.
  
  
  CONCLUSIONS
  Reflectance-mode confocal microscopy can play a role in non-invasive diagnosis of vulvar naevi, but further broader studies are required to validate our observations.
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, Cedex 2, France.
authors.forename: E
authors.initials: E
authors.lastname: Cinotti
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, Cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Couzan
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, Cedex 2, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Perrot
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, Cedex 2, France.
authors.forename: B
authors.initials: B
authors.lastname: Labeille
authors.affiliation: Dermatology Department, Hôpital Archet 2, Nice, France.|Centre de Recherche Clinique, CRC, Nice, France.|INSERM U 1065, Equipe 1, Nice, France.
authors.forename: P
authors.initials: P
authors.lastname: Bahadoran
authors.affiliation: Dermatology Department, University Hospital of Barcelona, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Puig
authors.affiliation: Dermatology Department, Hôpital Saint Vincent de Paul, GHICL, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Wantz
authors.affiliation: Dermatology Department, Hospital Sant Joan de Deu, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Vicente-Villa
authors.affiliation: Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Habougit
authors.affiliation: Pathology Department, Hôpital Archet 2, Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Butori
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, Cedex 2, France.
authors.forename: F
authors.initials: F
authors.lastname: Cambazard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D046169:Dermoscopy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008545:Melanoma / Q000175:diagnosis*; D018613:Microscopy, Confocal; D009506:Nevus / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis*; D014846:Vulvar Neoplasms / Q000175:diagnosis*