title: Study of low doses cisplatin synergistic effect on photodynamic outcome of aluminum phythalocyanine on soft tissue sarcoma (RD) cell line.
abstract: Photodynamic therapy (PDT) in combination with other treatment modality expects to overcome the drug resistance experienced in monotherapy. In this present work combination of chemo cum PDT is studied over the range of doses. It is found that treating cells/exposing cells to chemo drug (cisplatin, CDDP) and PDT individually results in minimal cell killing (∼7% and ∼16%) compared to the administration of chemo followed by PDT (∼50% cells were viable). These results showed that cell viability synergistically decreases in case of combination treatment as compared with individual treatment. Photodynamic therapy (PDT) in combination with CDDP chemotherapy expects to overcome the drug resistance experienced in monotherapy.
authors.affiliation: Department of Physics, Hazara University, Mansehra, Pakistan; Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan. Electronic address: safdar230@yahoo.com.
authors.forename: Safdar
authors.initials: S
authors.lastname: Ali
authors.affiliation: Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan.
authors.forename: Ahmat
authors.initials: A
authors.lastname: Khurshid
authors.affiliation: Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Maqsood
authors.affiliation: Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Rafi
authors.affiliation: Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan.
authors.forename: Junaid A
authors.initials: JA
authors.lastname: Khan
authors.affiliation: National Institute of Health, Chawk Shehzad, Park Road, Islamabad, Pakistan.
authors.forename: S S Z
authors.initials: SS
authors.lastname: Zaidi
authors.affiliation: Department of Physics, Hazara University, Mansehra, Pakistan.
authors.forename: Saleh
authors.initials: S
authors.lastname: Mohammad
authors.affiliation: Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad 45650, Pakistan.
authors.forename: Masroor
authors.initials: M
authors.lastname: Ikram
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012208:Rhabdomyosarcoma / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C048577:aluminum tetrasulfophthalocyanine; D002945:Cisplatin
keywords: Cell viability; Cisplatin; Diode laser; Neutral red; Photodynamic therapy; Rhabdomyosarcoma