title: Research on the immunosuppressive activity of ingredients contained in sunscreens.
abstract: The immunosuppressive properties of Benzophenone-4, an UV-filter and three ingredients, Allantoin, Bisabolol and Enoxolon used in sunscreen formulation, previously characterized as anti-inflammatory compounds, are studied. The results of this study demonstrate that four tested molecules have effects on DCs and T cells which are the most important cells of the immune system. The impact is also visible on keratinocyte cells which are in the direct contact with skin sunscreens. Each ingredient should be used with caution at reduced doses or even removed from some cosmetic preparations, such as sunscreens.
authors.affiliation: Département Cancer Pulmonaire et Cibles Moléculaires, Cibles et Médicaments des Infections et du Cancer, IICiMed EA 1155, UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes, Nantes Atlantique Universités, 1 rue Gaston Veil, 44035, Nantes, France.
authors.forename: Jihane
authors.initials: J
authors.lastname: Frikeche
authors.forename: Céline
authors.initials: C
authors.lastname: Couteau
authors.forename: Christos
authors.initials: C
authors.lastname: Roussakis
authors.forename: Laurence J M
authors.initials: LJ
authors.lastname: Coiffard
mesh_terms: D000481:Allantoin / Q000494:pharmacology; D001577:Benzophenones / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D006034:Glycyrrhetinic Acid / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013473:Sunscreening Agents / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D001577:Benzophenones; D016207:Cytokines; D007166:Immunosuppressive Agents; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; D013473:Sunscreening Agents; C009361:sulisobenzone; C004497:bisabolol; D000481:Allantoin; D006034:Glycyrrhetinic Acid