title: Novel approach of aceclofenac fast dissolving tablet.
abstract: Fast disintegrating tablets (FDTs) have received ever increasing demand during the last decade, and the ﬁeld has become a hastily growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Aceclofenac, an NSAID, has been recommended orally for the treatment of bone and connective tissue disorder and thus the formulation of the same resulted in development of several FDT technologies. The present aim is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti-inflammatory action. Besides, the conventional tablets also show poor patient compliance an attempt had been made to formulate for FDT of aceclofenac by using various super disintegrants like sodium starch glycolate, croscarmellose sodium and crosspovidone (polyplasdone XL) and PEG 6000 followed by novel technique. The tablets were evaluated for friability, hardness, weight variation, disintegration time, wetting time, in vitro dissolution studies and drug content studies. It was concluded that the batch which was prepared by using combination of crosspovidone and sodium starch glycolate as a super disintegrant shows excellent disintegration time, enhance dissolution rate, taste masking and hence lead to improve efficacy and bioavailability of drug.
authors.affiliation: Department of Pharmacy, Banasthali University, Rajasthan, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Dave
authors.affiliation: Department of Pharmacy, Banasthali University, Rajasthan, India.
authors.forename: Sachdev
authors.initials: S
authors.lastname: Yadav
authors.affiliation: Department of Pharmacy, Banasthali University, Rajasthan, India.
authors.forename: Swapnil
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Sheffield Hallam University, Howard St, Sheffield, South Yorkshire S1 1WB, UK.
authors.forename: Pushpendra
authors.initials: P
authors.lastname: Vishwakarma
authors.affiliation: Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan.
authors.forename: Nasir
authors.initials: N
authors.lastname: Ali
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D007700:Kinetics; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000031:analogs & derivatives / Q000737:chemistry; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D013607:Tablets; D014867:Water; D004008:Diclofenac; D013213:Starch; C048390:sodium starch glycolate; D011205:Povidone; D002266:Carboxymethylcellulose Sodium; C056498:aceclofenac