title: Extended elution of phospholipid from silicone hydrogel contact lenses.
abstract: Characterization of phospholipid release from an experimental reusable wear silicone hydrogel contact lens was performed to assess the possible use of these lenses for phospholipid delivery to increase eye comfort to patients who prefer reusable wear lenses. Contact lenses were loaded with 200 μg of radio-labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) from a solution of n-propanol. To simulate 30 days of diurnal use with overnight cleaning, these lenses were eluted for 16 h at 35 °C into artificial tear fluid (ATF), and then eluted at room temperature (~22 °C) for 8 h in one of three commercial contact lens cleaning systems. This was repeated for 30 days. The elution of DMPC into ATF was greater on the first day, followed by a fairly constant amount of elution each day thereafter. The type of cleaning system had a statistically significant effect on the elution rate during daily exposure to ATF. The rate of elution into cleaning solutions did not show any enhanced elution on the first day; there was a fairly constant elution rate. Again, the type of cleaning system significantly influenced the elution rate into the nightly cleaner.
authors.affiliation: a Chemical Engineering Department , Brigham Young University , 350 Clyde Bldg, Provo , UT 84602 , USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Pitt
authors.forename: Yibei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Jack
authors.forename: Krystian X
authors.initials: KX
authors.lastname: Perez
authors.forename: Peter W
authors.initials: PW
authors.lastname: Jones
authors.forename: Ryan
authors.initials: R
authors.lastname: Marelli
authors.forename: Jared L
authors.initials: JL
authors.lastname: Nelson
authors.forename: John D
authors.initials: JD
authors.lastname: Pruitt
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D018639:Contact Lens Solutions / Q000737:chemistry; D003263:Contact Lenses, Hydrophilic; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D065346:Lubricant Eye Drops / Q000737:chemistry; D008954:Models, Biological; D010743:Phospholipids / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D013696:Temperature
chemical_list: D002250:Carbon Radioisotopes; D018639:Contact Lens Solutions; D020100:Hydrogels; D065346:Lubricant Eye Drops; D010743:Phospholipids; D019275:Radiopharmaceuticals; D012828:Silicones; D000433:1-Propanol; D004134:Dimyristoylphosphatidylcholine
keywords: artificial tear fluid; diurnal wear; elution; lens cleaning systems; phospholipid delivery; silicone hydrogel contact lens