title: Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies.
abstract: Syndecan-1 (SDC1, synd, CD138) is the most widely studied member of four structurally related cell surface heparan sulfate proteoglycans (HSPG). Although SDC1 has been implicated in a wide range of biological functions, its altered expression often produces malignant phenotypes, which arise from increased cell proliferation and cell growth, cell survival, cell invasion and metastasis, and angiogenesis. Recent studies revealed much about the underlying molecular roles of SDC1 in these processes. The changes in SDC1 expression also have a direct impact on the clinical course of cancers, as evident by its prognostic significance. Accumulating evidence suggest that SDC1 is involved in stimulation of cancer stem cells (CSC) or tumor initiating cells (TIC) and this may affect disease relapse, and resistance to therapy. This review discusses the progress on the pro-tumorigenic role(s) of SDC1 and how these roles may impact the clinical aspect of the disease. Also discussed, are the current strategies for targeting SDC1 or its related signaling.
authors.affiliation: Biological Sciences, State University of New York College of Old Westbury, 233 Store Hill Road, Old Westbury, NY 11568, USA. Electronic address: gharbaranr@oldwestbury.edu.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Gharbaran
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002462:Cell Membrane / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D055354:Exosomes / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011379:Prognosis; D054730:Protein Interaction Domains and Motifs; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D012008:Recurrence; D053668:Syndecan-1 / Q000097:blood / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D016271:Proto-Oncogene Proteins c-myc; D053668:Syndecan-1
keywords: Cancer; Hematology; Oncology; Stem cells; Syndecan-1/CD138; Tumor