title: N-Bridged 5,6-bicyclic pyridines: Recent applications in central nervous system disorders.
abstract: The search for novel heterobicyclic compounds within the drug-like chemical space continues to be an area of interest in medicinal chemistry. Unsaturated N-bridgehead heterocycles are well represented in marketed drugs for a variety of therapeutic areas, and continue to play an important role in central nervous system (CNS) drug discovery programs. Examples of medicinal chemistry strategies that make use of N-bridged 5,6-bicyclic pyridines are discussed here in this Minireview, which covers the literature from 2010 up to 2014. B1-class imidazopyridines and B3-class pyrazolopyridines have proven to be at the forefront of molecular prototypes that are capable of interacting with disease relevant targets in neurodegeneration and neuropsychiatry.
authors.affiliation: Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Delgado
authors.affiliation: Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Delgado
authors.affiliation: Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Vega
authors.affiliation: Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain. Electronic address: atrabanc@its.jnj.com.
authors.forename: Andrés A
authors.initials: AA
authors.lastname: Trabanco
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011725:Pyridines; C023666:pyridine
keywords: CNS disorders; N-bridged 5,6-bicyclic pyridines; N-bridgehead pyridines