title: Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism.
abstract: The aim of this study was to evaluate serum activities of paraoxonase 1 (PON1) using three substrates; (1) 4-nitrophenylacetate (PON1n), (2) phenylacetate (PON1p), and (3) 5-thiobutyl butyrolactonase (PON1t), and butyrylcholinesterase (BChE) in dogs with hyperadrenocorticism (HAC). Serum activities of PON1 and BChE were higher in dogs with HAC than healthy dogs. There were strong positive correlations between PON1 activity measured with the three different substrates. This study demonstrated increased serum PON1 and BChE activities in dogs with HAC that could be attributed to the direct effect of glucocorticoids and lipid mobilisation.
authors.affiliation: Departament de Medicina i Cirugia Animals, Universidad Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.affiliation: San Marco Veterinary Hospital, Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caldin
authors.affiliation: Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Martinez-Subiela
authors.affiliation: Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
authors.affiliation: Departament de Medicina i Cirugia Animals, Universidad Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Pastor
authors.affiliation: Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100 Espinardo, Murcia, Spain. Electronic address: jjceron@um.es.
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Ceron
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D002091:Butyrylcholinesterase / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000209:etiology; D004285:Dogs; D005260:Female; D008297:Male
chemical_list: D002091:Butyrylcholinesterase; D043303:Aryldialkylphosphatase
keywords: Butyrylcholinesterase; Canine; Hyperadrenocorticism; Paraoxonase 1