title: No effect of energy intake overall on risk of endometrial cancers: a meta-analysis.
abstract: BACKGROUND
  Previous epidemiologic studies on the association between energy intake and endometrial cancer risk have only generated contradictory results. The role of energy intake in endometrial carcinogenesis thus remains unclear. To quantitatively assess the potential association between energy intake and endometrial cancer, a meta-analysis of case-control and cohort studies was here conducted.
  
  
  METHODS
  Eligible studies were retrieved via both computerized searches and review of references. Fixed-or random-effect models were used to summarize the estimates of OR with 95%CIs. Stratified analyses on study design, region and macronutrients' calorie were performed.
  
  
  RESULTS
  Sixteen studies met the inclusion criteria of the meta-analysis. No association between total energy intake and endometrial cancer was observed in either overall group (OR=1.11, 95%CI 0.92-1.30) or subgroups stratified by study design and region. In the specific macronutrients' calorie analysis, higher fat energy intake was found to be associated with increased endometrial risk (OR=1.72, 95%CI 1.12- 2.32) while energy from carbohydrate and protein was not related to endometrial cancer risk.
  
  
  CONCLUSIONS
  Our analysis did not support that total energy intake is related to endometrial cancer risk, in contrast to fat energy.
authors.affiliation: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China E-mail : zzjjhh@126.com.
authors.forename: Ke-Tan
authors.initials: KT
authors.lastname: Chu
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhou
mesh_terms: D002277:Carcinoma / Q000453:epidemiology*; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D012307:Risk Factors
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins