title: Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report.
abstract: BACKGROUND
  Anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction.
  
  
  METHODS
  Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis.
  
  
  CONCLUSIONS
  Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.
authors.affiliation: Department of Neurology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. Anne.Waschbisch@uk-erlangen.de.
authors.forename: Anne
authors.initials: A
authors.lastname: Waschbisch
authors.forename: Bernd
authors.initials: B
authors.lastname: Kallmünzer
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwab
authors.forename: Philipp
authors.initials: P
authors.lastname: Gölitz
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
authors.forename: De-Hyung
authors.initials: DH
authors.lastname: Lee
authors.forename: Ralf A
authors.initials: RA
authors.lastname: Linker
mesh_terms: D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D020278:Demyelinating Autoimmune Diseases, CNS / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D007074:Immunoglobulin G; D007155:Immunologic Factors; D016194:Receptors, N-Methyl-D-Aspartate; D000069283:Rituximab