title: Early graft dysfunction and mortality rate in marginal donor liver transplantation.
abstract: OBJECTIVE
  To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients.
  
  
  METHODS
  Donors with any 1 of following were considered marginal donors: age ≥65 years, sodium level ≥ 165 mmol/L and cold ischemia time ≥ 12 h. Donors were classified according to the donor risk index (DRI) < 1.7 and ≥ 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if < 20 and high if ≥ 20. Early graft dysfunction (EGD) and mortality rate were evaluated.
  
  
  RESULTS
  During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients was 45 years (range: 5-72 years) and 46 years (range: 4-66 years), respectively. In all, there were 15 marginal donors and 18 donors with a DRI > 1.7. In total, 4 LT patients that received livers from marginal donors and 5 that received livers from donors with a DRI ≥ 1.7 had EGD. Among the recipients of marginal livers, 5 died, versus 4 of the recipients of standard livers. There was no significant difference in EGD or mortality rate between the patients that received livers from marginal donors or those with a DRI ≥ 1.7 and patients that received standard donor livers.
  
  
  CONCLUSIONS
  Marginal and DRI ≥ 1.7 donors negatively affected LT outcomes, but not significantly.
authors.affiliation: Uludağ University, Bursa, Turkey. pinartasar@gmail.com
authors.forename: Pmar
authors.initials: P
authors.lastname: Sarkut
authors.forename: Bariş
authors.initials: B
authors.lastname: Gülcü
authors.forename: Remzi
authors.initials: R
authors.lastname: Işçimen
authors.forename: Murat
authors.initials: M
authors.lastname: Kiyici
authors.forename: Gürkan
authors.initials: G
authors.lastname: Türker
authors.forename: Naile Bolca
authors.initials: NB
authors.lastname: Topal
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Ozen
authors.forename: Ekrem
authors.initials: E
authors.lastname: Kaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D050377:Cold Ischemia; D058625:End Stage Liver Disease / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult