title: Formulation and evaluation of mini-tablets-filled-pulsincap delivery of lornoxicam in the chronotherapeutic treatment of rheumatoid arthritis.
abstract: In this present research work, we have designed a pulsincap formulation comprising mini-tablets, which to the best of our knowledge this combination has not been reported yet. We successfully combined the advantages of mini-tablets technology to meet the optimized requirements of our pulsincap formulation. Our main aim was to target lornoxicam to treat rheumatoid arthritis as per the chronotherapeutic pattern of the disease. Directly compressing method was used to prepare mini-tablets. The drug, polymers and combine mixtures of drug and polymers was evaluated for pre-formulation testing. Prepared mini-tablets were also evaluated for physicochemical, dissolution and stability studies. From FTIR and DSC evaluation, we found no interaction between the drug and polymers used. For mini-tablets, all the physico-chemical parameters were in limit. The mini-tablets of lornoxicam were filled into an insoluble body of capsule, and its opening was sealed by plugging it with a polymer. The complete capsule body after sealing with a cap was given enteric coating. Different polymers in various concentrations were used as a plug, to identify the most suitable which gives a complete lag time of 5 hours when combined with 5% CAP coating. HPMC-K100M in 30% and sodium alginate in 40% concentrations were identified as the most suitable plugs. Our optimized pulsincap formulations releases lornoxicam after a lag time of 5 hrs and maximum portion of the drug will be released in the early morning hours. It was also found to be stable for a period of 6 months as per ICH guidelines.
authors.affiliation: Department of Pharmaceutics, Bhaskar Pharmacy College, Yenkapally (V), Moinabad, RR District, Hyderabad, Telangana, India.
authors.forename: Mohd Abdul
authors.initials: MA
authors.lastname: Hadi
authors.affiliation: Jyothishmathi Institute of Pharmaceutical Science, Thimmapur, Karimnagar, Telangana, India.
authors.forename: Nidagurthi Guggilla Raghavendra
authors.initials: NG
authors.lastname: Rao
authors.affiliation: Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), RR District, Hyderabad, Telangana, India.
authors.forename: Avanapu Srinivasa
authors.initials: AS
authors.lastname: Rao
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D055870:Drug Chronotherapy; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D065347:Hypromellose Derivatives / Q000737:chemistry; D007700:Kinetics; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D011208:Powders; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D000464:Alginates; D018501:Antirheumatic Agents; D006603:Hexuronic Acids; D011208:Powders; D013607:Tablets; D010894:Piroxicam; D065347:Hypromellose Derivatives; D020723:Glucuronic Acid; C059451:lornoxicam