title: Treatment with statins and testosterone levels in men.
abstract: BACKGROUND
  Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones.Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower concentrations of: total testosterone (14.9 vs. 16.35 nmol/L, p = 0.008 after correction for body mass), free testosterone (32 vs. 39 pmol/L, p = 0.004), calculated free testosterone (0.32 vs. 0.36 nmol/L, p < 0.001) and bioavailable testosterone (6.10 vs. 7.56 nmol/L, p < 0.001) than age-matched controls.
  
  
  CONCLUSIONS
  We conclude that the use of statins may have an impact on the diagnosis of age-related testosterone deficiency in men.
authors.forename: Marek
authors.initials: M
authors.lastname: Mędraś
authors.affiliation: Department of Biological Principles of Sport, University School of Physical Education in Wroclaw, Wroclaw, Poland. eliza.kubicka@gmail.com.
authors.forename: Eliza
authors.initials: E
authors.lastname: Kubicka
authors.forename: Paweł
authors.initials: P
authors.lastname: Jóźkow
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Słowińska-Lisowska
authors.forename: Anna
authors.initials: A
authors.lastname: Trzmiel-Bira
authors.forename: Alicja
authors.initials: A
authors.lastname: Filus
mesh_terms: D000328:Adult; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone