title: Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report.
abstract: BACKGROUND
  Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.
  
  
  METHODS
  GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.
  
  
  RESULTS
  GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.
  
  
  CONCLUSIONS
  The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
authors.affiliation: 1. Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain.
authors.forename: Jonai
authors.initials: J
authors.lastname: Pujol-Gimenez
authors.affiliation: 2. School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.
authors.forename: Fátima Pérez
authors.initials: FP
authors.lastname: de Heredia
authors.affiliation: 3. Department of Pathology, Clínica Universidad de Navarra, Av. Pío XII 36, 31008 Pamplona, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Idoate
authors.affiliation: 4. School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Airley
authors.affiliation: 1. Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain.
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Lostao
authors.affiliation: 5. School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
authors.forename: Andrew Robert
authors.initials: AR
authors.lastname: Evans
keywords: Cancer cell lines; GLUT12; Glycolytic metabolism.; Immunohistochemistry; Spheroid