title: Does bupivacaine and fentanyl combination for epidural analgesia shorten the duration of labour?
abstract: In this study we aimed to explore the effects of epidural analgesia achieved by a combination of low-dose bupivacaine and fentanyl infused through an epidural catheter on mother, foetus and labour process in nulliparous at-term pregnant women during vaginal delivery. This study was designed in a prospective, randomised controlled manner. Epidural analgesia was achieved in 50 nulliparous women. Fifty nulliparous women did not undergo epidural analgesia procedure. The duration of the first stage of labour was significantly shortened, while the second stage was significantly lengthened in pregnant women who underwent epidural analgesia (p < 0.05). In conclusion, starting epidural analgesia application during the active phase of the first stage of labour may shorten the duration of the first stage compared with the group of nulliparous women not undergoing epidural analgesia. The factor that has an impact on this may be the addition of fentanyl to bupivacaine used for epidural analgesia.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Genc
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Sahin
authors.affiliation: b Department of Anaesthesia and Intensive Care , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: J
authors.initials: J
authors.lastname: Maral
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Celik
authors.affiliation: b Department of Anaesthesia and Intensive Care , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: A A
authors.initials: AA
authors.lastname: Kar
authors.affiliation: b Department of Anaesthesia and Intensive Care , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Usar
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Korkut
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sifa University , İzmir , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Guclu
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000009:adverse effects / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D005283:Fentanyl; D002045:Bupivacaine
keywords: bupivacaine; epidural analgesia; fentanyl; labour