title: An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents.
abstract: This paper describes a Deep Brain Stimulation device, portable, for chronic experiments on rodents in the context of Parkinson's disease. Our goal is to equip the animal with a device that mimics the human therapeutic conditions. It implies to respect a set of properties such as bilateral current-mode and charge-balanced stimulation, as well as programmability, low power consumption and re-usability to finally reach a suitable weight for long-term experiments. After the analysis of the solutions found in the literature, the full design of the device is explained. First, the stimulation front-end circuit driven by a processor unit, then the choice of supply sources which is a critical point for the weight and life-time of our system. Our low cost system has been realized using commercial discrete components and the overall power consumption was minimized. We achieved 6 days of maximal current stimulation with the chosen battery for a weight of 13.8 g . Finally, the device was carried out in vivo on rats during a 3 weeks experiment as the used implantation technique allows battery changing. This experiment also permits to emphasize the mechanical aspects including the packaging and electrodes holding.
authors.forename: Florian
authors.initials: F
authors.lastname: Kölbl
authors.forename: Gilles
authors.initials: G
authors.lastname: N'Kaoua
authors.forename: Frédéric
authors.initials: F
authors.lastname: Naudet
authors.forename: Florent
authors.initials: F
authors.lastname: Berthier
authors.forename: Emilie
authors.initials: E
authors.lastname: Faggiani
authors.forename: Sylvie
authors.initials: S
authors.lastname: Renaud
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Benazzouz
authors.forename: Noëlle
authors.initials: N
authors.lastname: Lewis
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004582:Electronics, Medical; D004867:Equipment Design; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000628:therapy*; D051381:Rats