title: Hierarchical construction of a mechanically stable peptide-graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo.
abstract: The design of hydrogels with controllable drug-release properties remains challenging. Here we report a hydrogel made of hierarchical graphene oxide sheets and peptide assemblies for on-demand drug release. The hydrogel possesses high drug-sustainability and the release of drugs can be precisely and remotely controlled through external stimuli.
authors.affiliation: National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, China 210093. caoyi@nju.edu.cn wangwei@nju.edu.cn.
authors.forename: Junhua
authors.initials: J
authors.lastname: Wu
authors.forename: Aiping
authors.initials: A
authors.lastname: Chen
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Guang
authors.initials: G
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Xue
authors.forename: Jiwu
authors.initials: J
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D012831:Bombyx / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010087:Oxides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D047011:Silk / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014183:Transplantation, Heterologous
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D010087:Oxides; D010455:Peptides; D047011:Silk; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006108:Graphite; D004317:Doxorubicin