title: An unusual case of sclerosing angiomatoid nodular transformation: radiological and histopathological analyses.
abstract: Sclerosing angiomatoid nodular transformation (SANT) is a rare benign primary vascular lesion of the spleen. Its etiology is still debated. Radiological characteristics are less known, although there are some reports regarding histopathological features ofSANT. A 21-year-old male patient was admitted to our hospital with fatigue, weight loss, and abdominal pain for 4 months. Physical examination, complete blood count, andbiochemical parameters were unremarkable. Dynamic contrast-enhanced computed tomography (CT) of the abdomen was performed. A heterogeneous well-defined hyperdense nodular lesion 3 cm in diameter was detected during the arterial phase. The detected lesion was seen as isodense with the spleen parenchyma during the portal venous and late venous phases. Magnetic resonance imaging (MRI) showed an isointense-hypointense nodular lesion on T1- and T2-weighted images. Intraabdominal LAM or splenomegaly was not detected. Microscopically, it was composed of angiomatoid nodules separated by central stellate fibrous stroma and fibrous septa. The contrast enhancement pattern was described as centrally hypovascular, radially progressive centripetal vascular contrast enhancement, called a spoke-wheel pattern in previously reported cases. We present CT and MRI findings and their correlation with histopathological findings of a case of unusual symptomatic SANT.
authors.affiliation: Department of Radiology, Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Melike Ruşen
authors.initials: MR
authors.lastname: Metin
authors.forename: Sehnaz
authors.initials: S
authors.lastname: Evrimler
authors.forename: Nurdan
authors.initials: N
authors.lastname: Çay
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Çetin
mesh_terms: D000328:Adult; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D055815:Young Adult