title: Clozapine-induced liver injury and pleural effusion.
abstract: Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.
authors.affiliation: Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast Royal Victoria Hospital , UK.
authors.forename: Joseph P M
authors.initials: JP
authors.lastname: Kane
authors.affiliation: Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast Royal Victoria Hospital , UK.
authors.forename: Francis A
authors.initials: FA
authors.lastname: O'Neill
keywords: adverse effects; clozapine; paranoid schizophrenia