title: Hypertriglyceridemia-induced pancreatitis and risk of persistent systemic inflammatory response syndrome.
abstract: BACKGROUND
  The mechanisms responsible for the development of acute pancreatitis (AP) and its complications are not fully understood.
  
  
  OBJECTIVE
  To assess the role of clinical and host molecular factors for the development and outcome of persistent systemic inflammatory response syndrome (SIRS) in patients with AP.
  
  
  METHODS
  We included 191 patients with AP in the study. The considered variables were demographic characteristics, prognosis and outcome, etiology, laboratory findings and complications. Interleukin (IL) 10 (-1082 G/A, -592 C/A), TNFA-308 (G/A) and ILB-31 (C/T) polymorphisms were determined by pyrosequencing. An amplification refractory mutation system-polymerase chain reaction method was used to genotype the IL8-251 (A/T) polymorphism.
  
  
  RESULTS
  Demographic characteristics were not statistically significant risk factors for the acquisition of persistent SIRS in patients with AP. Patients with hypertriglyceridemia were more likely to develop persistent SIRS (P < 0.05). No association with the TNFA, ILB, IL8-251 (A/T) and IL10 single-nucleotide polymorphisms was detected from the allele, genotype or haplotype frequencies.
  
  
  CONCLUSIONS
  Patients with hypertriglyceridemia-induced AP were more likely to develop persistent SIRS.
authors.affiliation: Gastroenterology Unit (FJBP, GVE, LDFM, OPG, JAGG, HJMG, EGG), University Hospital José Eleuterio González MD, Universidad Autónoma de Nuevo León, Monterrey, Mexico; Chemistry School (OGS), Universidad Autónoma de Nuevo León, San Nicolás de Los Garza, Mexico; and Clinical Pathology Department (EGG), University Hospital José Eleuterio González MD, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Bosques-Padilla
authors.forename: Genaro
authors.initials: G
authors.lastname: Vázquez-Elizondo
authors.forename: Omar
authors.initials: O
authors.lastname: González-Santiago
authors.forename: Lourdes
authors.initials: L
authors.lastname: Del Follo-Martínez
authors.forename: Oscar P
authors.initials: OP
authors.lastname: González
authors.forename: Jose A
authors.initials: JA
authors.lastname: González-González
authors.forename: Héctor J
authors.initials: HJ
authors.lastname: Maldonado-Garza
authors.forename: Elvira
authors.initials: E
authors.lastname: Garza-González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D055815:Young Adult
chemical_list: D016207:Cytokines