title: Endoglin (CD105) expression in sinonasal polyposis.
abstract: Despite appropriate surgical therapy, 5-10 % of patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) experience disease recurrences. It has been suggested that angiogenesis may relate to the pathogenesis and prognosis of CRS with NP. Endoglin (CD105) is a component of the receptor complex of transforming growth factor-beta, a pleiotropic cytokine that modulates angiogenesis. A series of patients treated surgically for CRS with NP was analyzed to assess the relationship between CD105 expression, main clinicopathological features, and recurrence rate. The immunohistochemical expression of CD105 was assessed in 70 patients consecutively operated for CRS with NP. In the univariate setting, the presence of CD105 (1/0) showed a trend towards a significant association with increasing NP dimensions (p = 0.054). Intensity of CD105 reaction was also significantly associated with NP size (0.04) and with an eosinophilic histology (p = 0.048). In our multivariate setting, only asthma (p = 0.016), hypereosinophilia (p = 0.022), and preoperative polyposis score (p = 0.046) retained their independent prognostic significance in relation to NP recurrence. Further efforts are needed to elucidate the biological, angiogenic and proliferative mechanisms behind recurrent NP. Our preliminary results support the clinical utility of extra postoperative care, in terms of closer follow-ups and medication with oral anti-histamines, topical and/or oral steroids, and antileukotrienes in patients with asthma, advanced nasal polyposis at presentation, and serum hypereosinophilia.
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy. giancarlo.ottaviano@unipd.it.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ottaviano
authors.affiliation: Department of Medicine DIMED, Padova University, Padua, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Cappellesso
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mylonakis
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lionello
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Favaretto
authors.affiliation: Department of Medicine DIMED, Padova University, Padua, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Giacomelli
authors.affiliation: Department of Medicine DIMED, Padova University, Padua, Italy.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Spoladore
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Marchese-Ragona
authors.affiliation: Department of Medicine DIMED, Padova University, Padua, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Marino
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Staffieri
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martini
authors.affiliation: Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D001249:Asthma / Q000150:complications; D002908:Chronic Disease; D000071063:Endoglin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D012852:Sinusitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface
keywords: CD105; Nasal polyposis; Nasal polyps relapse; Surgery