title: Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes.
abstract: The molecular recognition of human telomeric G-quadruplexes by a novel cationic π-extended Ni(II)-porphyrin (Ni(II)-TImidP4) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted Ni(II)-porphyrin (Ni(II)-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of Ni(II)-TImidP4 towards human telomeric G4 than that of Ni(II)-TMPyP4.
authors.affiliation: Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons - UMONS, 20 Place du Parc, B-7000 Mons, Belgium. mathieu.surin@umons.ac.be.
authors.forename: Jenifer
authors.initials: J
authors.lastname: Rubio-Magnieto
authors.forename: Florent
authors.initials: F
authors.lastname: Di Meo
authors.forename: Mamadou
authors.initials: M
authors.lastname: Lo
authors.forename: Cécile
authors.initials: C
authors.lastname: Delcourt
authors.forename: Sébastien
authors.initials: S
authors.lastname: Clément
authors.forename: Patrick
authors.initials: P
authors.lastname: Norman
authors.forename: Sébastien
authors.initials: S
authors.lastname: Richeter
authors.forename: Mathieu
authors.initials: M
authors.lastname: Linares
authors.forename: Mathieu
authors.initials: M
authors.lastname: Surin
mesh_terms: D001665:Binding Sites; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
chemical_list: D008665:Metalloporphyrins; D009532:Nickel