title: Isocyanates and human health: multistakeholder information needs and research priorities.
abstract: OBJECTIVE
  To outline the knowledge gaps and research priorities identified by a broad base of stakeholders involved in the planning and participation of an international conference and research agenda workshop on isocyanates and human health held in Potomac, Maryland, in April 2013.
  
  
  METHODS
  A multimodal iterative approach was used for data collection including preconference surveys, review of a 2001 consensus conference on isocyanates, oral and poster presentations, focused break-out sessions, panel discussions, and postconference research agenda workshop.
  
  
  RESULTS
  Participants included representatives of consumer and worker health, health professionals, regulatory agencies, academic and industry scientists, labor, and trade associations.
  
  
  CONCLUSIONS
  Recommendations were summarized regarding knowledge gaps and research priorities in the following areas: worker and consumer exposures; toxicology, animal models, and biomarkers; human cancer risk; environmental exposure and monitoring; and respiratory epidemiology and disease, and occupational health surveillance.
authors.affiliation: From the Department of Environmental Health (Dr Lockey), Division of Occupational and Environmental Medicine, Pulmonary Division--Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio; Yale Occupational and Environmental Medicine (Dr Redlich), Yale School of Medicine, New Haven, Conn; Division of Applied Research and Technology (Dr Streicher), National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Risk Assessment Division (Ms Pfahles-Hutchens), Office of Chemical Safety and Pollution Prevention, US Environmental Protection Agency, Washington, DC; Office of Clinical Toxicology (Dr Hakkinen), Specialized Information Services, National Library of Medicine, National Institutes of Health; Epidemiology and Genomics Research Program (Dr Ellison), Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Md; Mel and Enid Zuckerman College of Public Health (Dr Harber), University of Arizona, Tucson; Occupational and Environmental Medicine (Dr Utell), University of Rochester Medical Center, NY; Holland Associates (Dr Holland), Palo Alto, Calif; International Union (Mr Comai), UAW, Health and Safety, Detroit, Mich; and Department of Family Practice (Dr White), University of British Columbia, and Canadian Institute for the Relief of Pain and Disability, Vancouver, Canada.
authors.forename: James E
authors.initials: JE
authors.lastname: Lockey
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Redlich
authors.forename: Robert
authors.initials: R
authors.lastname: Streicher
authors.forename: Andrea
authors.initials: A
authors.lastname: Pfahles-Hutchens
authors.forename: Pertti Bert J
authors.initials: PB
authors.lastname: Hakkinen
authors.forename: Gary L
authors.initials: GL
authors.lastname: Ellison
authors.forename: Philip
authors.initials: P
authors.lastname: Harber
authors.forename: Mark
authors.initials: M
authors.lastname: Utell
authors.forename: John
authors.initials: J
authors.lastname: Holland
authors.forename: Andrew
authors.initials: A
authors.lastname: Comai
authors.forename: Marc
authors.initials: M
authors.lastname: White
mesh_terms: D015415:Biomarkers; D035843:Biomedical Research; D003226:Congresses as Topic; D032921:Consensus; D003257:Consumer Product Safety; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D006292:Health Priorities; D006801:Humans; D017953:Isocyanates / Q000633:toxicity*; D023421:Models, Animal; D009369:Neoplasms / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D016272:Occupational Health; D012140:Respiratory Tract Diseases / Q000139:chemically induced*
chemical_list: D015415:Biomarkers; D017953:Isocyanates