title: Recent Advances in Optical Molecular Imaging and its Applications in Targeted Drug Delivery.
abstract: Optical molecular imaging has been frequently used in many preclinical researches including cancer detection, tumor mechanism study, drug efficacy evaluation and targeted drug delivery. Among optical molecular imaging modalities, bioluminescence imaging and fluorescence imaging have acquired certain degree of development and attracted more and more attention in recent years for their high sensitivity and low cost. With the development of optical technology and probe technology, two-photon microscopy imaging and Raman imaging have been widely used in drug evaluation and tumor studies through cell and tissue imaging. This paper focuses on the occurrence and development of optical molecular imaging especially for its imaging method imaging system and its application in target drug delivery. Finally, the existing challenges and brand new applications of optical imaging techniques in drug delivery research are discussed.
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Hui
authors.forename: Wenting
authors.initials: W
authors.lastname: Shang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Jia
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Key Laboratory of Molecular Imaging of Chinese Academy of Sciences, Beijing Key Laboratory of Molecular Imaging, Beijing, 100190, China. jie.tian@ia.ac.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D005453:Fluorescence; D006801:Humans; D008163:Luminescent Measurements; D057054:Molecular Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*