title: Levels of soluble E-cadherin in breast, gastric, and colorectal cancers.
abstract: Soluble E-cadherin is a 80 kDa protein fragment coming from the proteolytic cleavage of the extracellular domain of the full length epithelial cadherin, a molecule involved in cell adhesion/polarity and tissue morphogenesis. In comparison with normal epithelia, cancer cells show a decreased cadherin-mediated intercellular adhesion, and sE-cad levels normally increase in body fluids (blood and urine). This review focuses on soluble E-cadherin in sera of patients affected by three solid cancers (breast, gastric, and colorectal cancers) and how its levels correlate or not with some cancer parameters (e.g., dimension, progression, and localisation). We will describe the main proteomics approaches adopted to measure sE-cad both in vivo and in vitro and the most important findings about its behaviour in cancer dynamics.
authors.affiliation: Facility of Bio-Proteomics, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy.
authors.forename: Ombretta
authors.identifier: 0000-0002-0785-5066
authors.initials: O
authors.lastname: Repetto
authors.affiliation: Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy.
authors.forename: Paolo
authors.identifier: 0000-0002-9502-1781
authors.initials: P
authors.lastname: De Paoli
authors.affiliation: Facility of Bio-Proteomics, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy.
authors.forename: Valli
authors.initials: V
authors.lastname: De Re
authors.affiliation: Pathology Unit, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy.
authors.forename: Vincenzo
authors.identifier: 0000-0001-6010-0976
authors.initials: V
authors.lastname: Canzonieri
authors.affiliation: Gastroenterology Unit, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy.
authors.forename: Renato
authors.identifier: 0000-0002-2020-222X
authors.initials: R
authors.lastname: Cannizzaro
mesh_terms: D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D015820:Cadherins / Q000096:biosynthesis* / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D013274:Stomach Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D015820:Cadherins