title: Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.
abstract: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Jia Ni
authors.initials: JN
authors.lastname: Yu
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Chang Qing
authors.initials: CQ
authors.lastname: Guo
authors.affiliation: Acupuncture & Moxibustion and Physiotherapy Department, Beijing Shuili Hospital, No. 19 Yu Yuan Tan South Road, Haidian District, Beijing 100036, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: Acupuncture and Moxibustion Department, China-Japan Friendship Hospital, No. 2 The Ying Hua Yuan East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Nai Gang
authors.initials: NG
authors.lastname: Liu
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Sun
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Hai Xia
authors.initials: HX
authors.lastname: Wu
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Chu Xi
authors.initials: CX
authors.lastname: Liang
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Zhan Xia
authors.initials: ZX
authors.lastname: Chen
authors.affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
authors.forename: Xiao Hong
authors.initials: XH
authors.lastname: Li