title: Carboxymethyl cellulose acetate butyrate: a review of the preparations, properties, and applications.
abstract: Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations.
authors.affiliation: Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt.
authors.forename: Mohamed
authors.identifier: 0000-0002-5095-3112
authors.initials: M
authors.lastname: El-Sakhawy
authors.affiliation: Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt.
authors.forename: Samir
authors.initials: S
authors.lastname: Kamel
authors.affiliation: Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Salama
authors.affiliation: Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt.
authors.forename: Hebat-Allah
authors.initials: HA
authors.lastname: Sarhan