title: α-Alkylation of a norbornene-derived tricyclic ketone: are steric factors really in control?
abstract: Density functional theory (DFT) has been used to investigate the α-alkylation of a chiral tricyclic ketone. These calculations reveal that torsional strain and a strong conformational preference, rather than steric influences, are responsible for the high levels of observed stereoselectivity and suggest a way by which alternative stereoisomers could be accessed.
authors.affiliation: Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, MN 55455, USA. harned@umn.edu.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Harned