title: [Comparative analysis of parameters of humoral and cell specific immunity in individuals immunized with a live tularemia vaccine].
abstract: OBJECTIVE
  Comparative analysis of parameters of humoral and cell immunity in individuals, vaccinated against tularemia.
  
  
  METHODS
  Sera and blood samples of 258 immunized individuals were studied by indirect hemagglutination and leukocytolis with tularin reaction.
  
  
  RESULTS
  73% of the examined individuals had both specific antibodies and positive values of cell immunity. The presence of anti-tularemia immunity was registered in 26 of 30 individuals immunized 10 - 20 years ago. However in 76 individuals (26%) we have detected discrepancies of the results of the 2 methods that complicate the evaluation of specific immunity status. As such, the use of only 1 method characterizing either humoral or cell immunity does not give objective information.
  
  
  CONCLUSIONS
  The use of 2 methods directed on detection of both specific antibodies and delayed-type hypersensitivity reaction is reasonable for the increase of validity of results of anti-tularemia immunity status evaluation. Only positive immunologic parameters of both tests confirm the presence of immunity against Francisella tularensjs and the possibility of revaccination period delay.
authors.forename: N V
authors.initials: NV
authors.lastname: Aronova
authors.forename: N N
authors.initials: NN
authors.lastname: Onoprienko
authors.forename: M V
authors.initials: MV
authors.lastname: Tsimbalistova
authors.forename: N V
authors.initials: NV
authors.lastname: Pavlovich
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000276:immunology; D005604:Francisella tularensis / Q000276:immunology / Q000472:pathogenicity; D006386:Hemagglutination Tests; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D014406:Tularemia / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D014611:Vaccination / Q000379:methods; D014613:Vaccines, Attenuated / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated