title: Treatment for a eumycetoma infection caused by Aspergillus in an immunocompromised host: a case report.
abstract: Eumycetoma is a chronic infection of the skin and subcutaneous tissue caused by filamentous fungi, which usually occurs in tropical or subtropical countries. We report a case of an immunocompromised patient presenting with presumed eumycetoma in the United States and his subsequent treatment with voriconazole. The use of voriconazole and liposomal amphotericin B halted the progression and allowed gradual resolution of the infection. The patient will require close monitoring and long-term therapy with voriconazole to obtain a clinical cure. Voriconazole and liposomal amphotericin B are potential initial treatment options, with long-term voriconazole maintenance therapy, for an Aspergillus-induced eumycetoma.
authors.affiliation: College of Pharmacy, Department of Clinical and Administrative Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hopps
authors.forename: A
authors.initials: A
authors.lastname: Roach
authors.forename: C
authors.initials: C
authors.lastname: Yuen
authors.forename: E
authors.initials: E
authors.lastname: Borders
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D001230:Aspergillus / Q000187:drug effects*; D005658:Fungi; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D008297:Male; D008271:Mycetoma / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D014481:United States; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole
keywords: Aspergillus; eumycetoma; hematopoietic stem cell transplant; liposomal amphotericin B; voriconazole