title: Lanthanide-doped luminescent nano-bioprobes for the detection of tumor markers.
abstract: Sensitive and specific biodetection of tumor markers is essential for early-stage cancer diagnosis and therapy, and will ultimately increase the patient survival rate. As a new generation of luminescent bioprobes, lanthanide (Ln(3+))-doped inorganic luminescent nanoparticles have attracted considerable interest for a variety of biomedical applications due to their superior physicochemical properties. In this feature article, we provide a brief overview of the most recent advances in the development of Ln(3+)-doped luminescent nano-bioprobes and their promising applications for in vitro detection of tumor markers with an emphasis on the establishment of state-of-the-art assay techniques, such as heterogeneous time-resolved (TR) luminescent bioassay, dissolution-enhanced luminescent bioassay, upconversion (UC) luminescent bioassay, homogeneous TR Förster resonance energy transfer (TR-FRET) and UC-FRET bioassays. Some future prospects and efforts towards this emerging field are also envisioned.
authors.affiliation: Key Laboratory of Optoelectronic Materials Chemistry and Physics, and Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. xchen@fjirsm.ac.cn.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Datao
authors.initials: D
authors.lastname: Tu
authors.forename: Shanyong
authors.initials: S
authors.lastname: Zhou
authors.forename: Mingdong
authors.initials: M
authors.lastname: Huang
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D001681:Biological Assay / Q000379:methods*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor; D014315:Triterpenes; C532286:lantanoic acid