title: TAp73 promotes anti-senescence-anabolism not proliferation.
abstract: TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK. Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Agostini
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK. Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary.
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Niklison-Chirou
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: Catani
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Knight
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK. Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy. Biochemistry Laboratory IDI-IRCC, c/o Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK. Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester UK.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rufini
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D059447:Cell Cycle Checkpoints; D016923:Cell Death; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016922:Cellular Senescence; D002540:Cerebral Cortex / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism; D015972:Gene Expression Regulation, Neoplastic; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D009711:Nucleotides / Q000096:biosynthesis; D012516:Osteosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010427:Pentose Phosphate Pathway; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D009711:Nucleotides; C000606460:TP73 protein, human; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins