title: New alkylresorcinols from a lipophilic extract of Urginea indica L. bulbs showing experimental trauma healing activity.
abstract: Several alkylresorcinols presenting the substitution pattern of structures I (3-methyl ether of 5-alkyl-2-methylresorcinol) and II (1,3-dimethyl ether of 5-alkylresorcinol), were isolated from the dichloromethane extract of the air-dried bulbs of Urginea indica L. Compounds of structure I with 15, 17 and 20 carbon atoms in the alkyl chain as well as compounds of structure II with 20, 22, 24 carbon atoms in the alkyl chain are new. The structures of the new compounds were elucidated on the basis of their NMR and MS data. The exact number of homologues in each series I and II and the exact length of the side chain were found using GC-MS analysis. The dichloromethane extract of the bulbs was evaluated for its trauma healing properties after local application and a statistically significant tendency to trauma remodeling was observed in comparison to control groups.
authors.affiliation: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece; Department of Pharmacology, Medical School, University Athens, M. Asias 75, Athens 11527, Greece.
authors.forename: Hudu Garba
authors.initials: HG
authors.lastname: Mikail
authors.affiliation: Aretaieio Hospital, Medical School, University of Athens, Vas. Sophias 76, Athens 11528, Greece.
authors.forename: Helen
authors.initials: H
authors.lastname: Karvouni
authors.affiliation: Aretaieio Hospital, Medical School, University of Athens, Vas. Sophias 76, Athens 11528, Greece.
authors.forename: Antonia
authors.initials: A
authors.lastname: Kotsiou
authors.affiliation: Department of Pharmacology, Medical School, University Athens, M. Asias 75, Athens 11527, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Tesseromatis
authors.affiliation: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece. Electronic address: magiatis@pharm.uoa.gr.
authors.forename: Prokopios
authors.initials: P
authors.lastname: Magiatis
mesh_terms: D000818:Animals; D031448:Drimia / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D017208:Rats, Wistar; D012118:Resorcinols / Q000302:isolation & purification / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D012118:Resorcinols
keywords: Alkyresorcinols; Cichoriols; Trauma healing; Urginea indica