title: [Clinical characteristics and prognostic factors of pulmonary tuberculosis with concurrent lung cancer].
abstract: OBJECTIVE
  To explore the clinical characteristics and prognostic factors of pulmonary tuberculosis with concurrent lung cancer.
  
  
  METHODS
  Comprehensive analyses were conducted for 58 cases of pulmonary tuberculosis patients with lung cancer. Their clinical symptoms, signs and imaging results were analyzed between January 1998 and January 2005 at Qingdao Chest Hospital. Kaplan-Meier method was utilized to calculate their survival rates. Nine prognostic characteristics were analyzed. Single factor analysis was performed with Logrank test and multi-factor analysis with Cox regression model.
  
  
  RESULTS
  The initial symptoms were cough, chest tightness, fever and hemoptysis. Chest radiology showed the coexistence of two diseases was 36 in the same lobe and 22 in different lobes. And there were pulmonary nodules (n = 24), cavities (n = 19), infiltration (n = 8) and atelectasis (n = 7). According to the pathological characteristics, there were squamous carcinoma (n = 33), adenocarcinoma (n = 17), small cell carcinoma (n = 4) and unidentified (n = 4) respectively. The TNM stages were I (n = 13), II(n = 22), III (n = 16) and IV (n = 7) respectively. The median survival period was 24 months. And the 1, 3, 5-year survival rates were 65.5%, 65.5% and 29.0% respectively. Single factor analysis showed that lung cancer TNM staging (P = 0.000) and tuberculosis activity (P = 0.024) were significantly associated with patient prognosis. And multi-factor analysis showed that lung cancer TNM staging (RR = 2.629, 95%CI: 1.759-3.928, P = 0.000) and tuberculosis activity (RR = 1.885, 95%CI: 1.023-3.471, P = 0.042) were relatively independent prognostic factors.
  
  
  CONCLUSIONS
  The clinical and radiological characteristics contribute jointly to early diagnosis and therapy of tuberculosis with concurrent lung cancer. And TNM staging of lung cancer and activity of tuberculosis are major prognostic factors.
authors.affiliation: Department of Respiratory Medicine, Qingdao Chest Hospital & Cardiovascular Medicine, Qingdao 266043, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Gu
authors.forename: Yelin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Email: liuyufengqd@126.com.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma; D002294:Carcinoma, Squamous Cell; D003371:Cough; D006469:Hemoptysis; D006801:Humans; D008175:Lung Neoplasms; D009367:Neoplasm Staging; D011379:Prognosis; D001261:Pulmonary Atelectasis; D055752:Small Cell Lung Carcinoma; D015996:Survival Rate; D014397:Tuberculosis, Pulmonary