title: Pattern ERG in central serous retinopathy.
abstract: BACKGROUND
  To evaluate the pattern electroretinogram (PERG) in central serous retinopathy.
  
  
  METHODS
  In this prospective study, 20 patients with recent onset (<6 weeks) unilateral CSR were studied with the fellow eye acting as control. BCVA, psychophysical parameters, FFA, OCT, flash and pattern ERG were evaluated.
  
  
  RESULTS
  The mean P50 amplitude in the affected eye at presentation was 2.36 ± 0.8 μv compared to 3.24 ± 0.85 μv in the normal eye. At 12 weeks, the mean P50 amplitude in the affected eye was 3.16 ± 0.88 μv compared to 3.63 ± 0.82 μv in the normal eye. The reduction of 27 % in P50 amplitude even after recovery was statistically significant (P < 0.001). A reduction of 19.77 % in the amplitude of N95 wave in the affected eye compared to the normal eye was seen, which was statistically significant (P < 0.001). In the affected eye, there was statistically significant improvement in the psychophysical tests at 12 weeks.
  
  
  CONCLUSIONS
  This study reveals that P50 component of the PERG is reduced in cases of CSR, indicating functional disturbance of the macular photoreceptors. A normal flash ERG indicates that pathology is electrophysiologically localised to macula without affecting general retina. Residual deficit in the PERG explains poor quality of vision in spite of normal anatomical apposition and quantitative 6/6 visual acuity.
authors.affiliation: Guru Nanak Eye Centre, Maulana Azad Medical College, Maharaja Ranjeet Singh Marg, New Delhi, 110002, India.
authors.forename: Jawahar Lal
authors.initials: JL
authors.lastname: Goyal
authors.forename: Basudeb
authors.initials: B
authors.lastname: Ghosh
authors.forename: Vishram
authors.initials: V
authors.lastname: Sangit
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Parul
authors.initials: P
authors.lastname: Jain
authors.forename: Vikas
authors.initials: V
authors.lastname: Veerwal
authors.forename: Ritu
authors.initials: R
authors.lastname: Arora
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000503:physiopathology*; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult