title: [Regenerative medicine of the intervertebral disc: from pathophysiology to clinical application].
abstract: A large proportion of low back pain may be explained by intervertebral disc (IVD) degeneration. Currently, the process leading to IVD degeneration highlights the pivotal role of IVD cells. The number of these cells drastically decreases and does not support a spontaneous repair of the tissue. In order to counteract IVD degeneration, regenerative medicine, based on a cell supplementation of the damaged tissue is considered as a promising approach. After a description of IVD physiopathology, we will develop the different strategies based on cell therapy and tissue engineering and currently under investigation to improve altered IVD degeneration. Finally, results from the current pre-clinical and clinical studies will be discussed.
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - Université de Nantes, UFR sciences et techniques, 44042 Nantes, France.
authors.forename: Nina
authors.initials: N
authors.lastname: Henry
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Colombier
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - Université de Nantes, UFR sciences et techniques, 44042 Nantes, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Lescaudron
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - CHU Nantes, PHU4 OTONN, service de neurotraumatologie, 44042 Nantes, France - Université de Nantes, UFR Médecine, 44042 Nantes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hamel
authors.affiliation: Institut des matériaux Jean Rouxel (IMN), UMR6502 université de Nantes-CNRS, 44322 Nantes, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Le Bideau
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - CHU Nantes, PHU 4 OTONN, 44042 Nantes, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guicheux
authors.affiliation: Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - CHU Nantes, PHU 7 biologie-pharmacie, pharmacie centrale, 44042 Nantes, France - Université de Nantes, UFR sciences biologiques et pharmaceutiques, 44042 Nantes, France.
authors.forename: Johann
authors.initials: J
authors.lastname: Clouet
mesh_terms: D001672:Biocompatible Materials; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007403:Intervertebral Disc / Q000502:physiology*; D055959:Intervertebral Disc Degeneration / Q000628:therapy*; D012038:Regeneration; D023822:Tissue Engineering; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials