title: Endothelin receptors, renal effects and blood pressure.
abstract: The endothelin system has emerged as a key player in the renal control of salt and water homeostasis, exerting profound effects on both the renal vasculature and tubular epithelial cells. Recent advances include new actions of endothelins in the glomerulus, an emerging role for the ETA receptor in chronic kidney disease (CKD) progression and in tubular function, and a more detailed understanding of the tubular response to high salt intake. A large body of evidence also implicates dysfunction of the endothelin system in hypertension, particularly salt-sensitive hypertension, although recent data suggests important sex-differences may exist. Finally, clinical trials indicate that antagonists of endothelin receptors hold great promise in treating resistant hypertension and proteinuric renal disease.
authors.affiliation: Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: erika.boesen@unmc.edu.
authors.forename: Erika I
authors.initials: EI
authors.lastname: Boesen
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004231:Diuresis; D065128:Endothelin Receptor Antagonists / Q000627:therapeutic use; D019332:Endothelin-1 / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000188:drug therapy / Q000503:physiopathology*; D017466:Receptors, Endothelin / Q000502:physiology*
chemical_list: D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D017466:Receptors, Endothelin