title: First confirmed case of native polyomavirus BK nephropathy in a liver transplant recipient seven years post-transplant.
abstract: Renal dysfunction frequently occurs in liver transplant recipients and is associated with increased morbidity and mortality. BK virus is a human polyoma virus that reactivates during immunocompromised states and is a known cause of renal allograft dysfunction in renal transplant recipients. However, BK nephropathy of native kidneys is rare in non-renal transplant recipients. There is no published data linking BK virus and renal dysfunction in liver transplant recipients. We describe the first confirmed case of native polyomavirus BK nephropathy in a liver transplant recipient. BK nephropathy should be considered in the differential diagnosis of new renal failure in liver transplant recipients.
authors.affiliation: Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Yangmin
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Magil
authors.affiliation: Trana Hussaini Faculty of Pharmaceutical Sciences University of British Columbia, Vancouver, BC, Canada.
authors.forename: Trana
authors.initials: T
authors.lastname: Hussaini
authors.affiliation: Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: C Kit
authors.initials: CK
authors.lastname: Yeung
authors.affiliation: Division of Gastroenterology. University of British Columbia, Vancouver, BC, Canada.
authors.forename: Siegfried R
authors.initials: SR
authors.lastname: Erb
authors.affiliation: Division of Gastroenterology. University of British Columbia, Vancouver, BC, Canada.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Marquez-Alazagara
authors.affiliation: Division of Gastroenterology. University of British Columbia, Vancouver, BC, Canada.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida
mesh_terms: D001739:BK Virus; D015209:Cholangitis, Sclerosing / Q000150:complications; D058625:End Stage Liver Disease / Q000209:etiology / Q000601:surgery; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000139:chemically induced*; D014412:Tumor Virus Infections / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents