title: Expedient metal-free synthesis of 1,3-oxazinen-4-ones.
abstract: 1,3-Oxazinen-4-ones are medicinally important scaffolds which have traditionally been accessed using a hetero-Diels-Alder approach or more recently using a cobalt-catalyzed three-component cycloaddition. Herein we report a novel strategy to access this scaffold which allows for the rapid and high yielding synthesis of 1,3-oxazinen-4-ones under ambient temperature and pressures with improved substrate scope.
authors.affiliation: Department of Chemistry, University of Otago , Dunedin 9054, New Zealand.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Craig
authors.forename: Louise
authors.initials: L
authors.lastname: van der Salm
authors.forename: Lars
authors.initials: L
authors.lastname: Stevens-Cullinane
authors.forename: Nigel T
authors.initials: NT
authors.lastname: Lucas
authors.forename: Eng Wui
authors.initials: EW
authors.lastname: Tan
authors.forename: Bill C
authors.initials: BC
authors.lastname: Hawkins
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D061565:Cycloaddition Reaction; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008670:Metals; D010078:Oxazines; D003035:Cobalt