title: CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes.
abstract: Many studies have suggested that CXCR3, CXCR5, CXCR6 and CXCR7 chemokine receptors are determinant in type 1 diabetes (T1D), expecially in autoimmunity and β-cell destruction. In particular circulating CXCL10 level (the ligand of CXCR3) is high in T1D patients, and this suggests that CXCL10 may be a candidate for a predictive marker of T1D. Blocking the CXCL10/CXCR3 axis in newly onset of diabetes seems to be a potential strategy for the therapy of T1D. Attempts have been done in modulating or blocking CXCR5, CXCR6 and CXCR7 chemokine receptors in experimental settings of T1D. More researches are necessary to evaluate the interplay among cytokines, chemokines and the pathogenesis and therapy of T1D.
authors.forename: Poupak
authors.initials: P
authors.lastname: Fallahi
authors.forename: Alda
authors.initials: A
authors.lastname: Corrado
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Domenicantonio
authors.forename: Giada
authors.initials: G
authors.lastname: Frenzilli
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy. alessandro.antonelli@med.unipi.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Antonelli
authors.forename: Silvia Martina
authors.initials: SM
authors.lastname: Ferrari
mesh_terms: D054357:Chemokine CXCL10 / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D054387:Receptors, CXCR / Q000378:metabolism*; D054367:Receptors, CXCR3 / Q000378:metabolism; D054380:Receptors, CXCR5 / Q000378:metabolism; D000075744:Receptors, CXCR6; D019707:Receptors, Chemokine / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C501896:ACKR3 protein, human; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; C095085:CXCR5 protein, human; C106330:CXCR6 protein, human; D054357:Chemokine CXCL10; D054387:Receptors, CXCR; D054367:Receptors, CXCR3; D054380:Receptors, CXCR5; D000075744:Receptors, CXCR6; D019707:Receptors, Chemokine; D011991:Receptors, Virus