title: Current status of gene therapy for hepatocellular carcinoma, with a focus on gene delivery approaches.
abstract: Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.forename: Zongguang
authors.initials: Z
authors.lastname: Tai
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, Changhai Hospital, 168# Changhai Road, Shanghai 200433, China. liullk@126.com.
authors.forename: Shen
authors.initials: S
authors.lastname: Gao
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008081:Liposomes / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000235:genetics / Q000628:therapy*
chemical_list: D008081:Liposomes