title: Imaging of extraosseous intracranial and intraspinal multiple myeloma, including central nervous system involvement.
abstract: Involvement of the central nervous system by multiple myeloma is rare and has a very poor prognosis. Magnetic resonance imaging of the head and spine plays an important role in diagnosing central nervous system involvement with multiple myeloma. We retrospectively analyzed the imaging features of pathology-proven extraosseous intracranial and intraspinal multiple myeloma from 2002 to 2013. The most common imaging manifestations were extraaxial nonosseous spinal lesions, cranial nerve involvement, and intracranial extraaxial nonosseous lesions. Different sites in the central nervous system may be affected by multiple myeloma, often simultaneously, producing a variety of imaging appearances.
authors.affiliation: Department of Radiology, Icahn School of Medicine, Mount Sinai Health System, New York. Electronic address: katyats@gmail.com.
authors.forename: Katya A
authors.initials: KA
authors.lastname: Shpilberg
authors.affiliation: Department of Radiology, Icahn School of Medicine, Mount Sinai Health System, New York.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Esses
authors.affiliation: Department of Pathology, Icahn School of Medicine, Mount Sinai Health System, New York.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Fowkes
authors.affiliation: Department of Oncology, Icahn School of Medicine, Mount Sinai Health System, New York.
authors.forename: Ajai
authors.initials: A
authors.lastname: Chari
authors.affiliation: Department of Radiology, Icahn School of Medicine, Mount Sinai Health System, New York.
authors.forename: Michael
authors.initials: M
authors.lastname: Sacher
authors.affiliation: Department of Radiology, Icahn School of Medicine, Mount Sinai Health System, New York.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Naidich
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D013116:Spinal Cord / Q000473:pathology*; D013904:Thoracic Vertebrae
keywords: Brain MRI; CNS involvement; Extraosseous myeloma; Multiple myeloma; Spine MRI