title: Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy.
abstract: Theranostics for in vivo cancer diagnosis and treatment generally requires well-designed nanoscale platforms with multiple integrated functionalities. In this study, we uncover that functionalized iron oxide nanoparticles (IONPs) could be self-assembled on the surface of two-dimensional MoS2 nanosheets via sulfur chemistry, forming MoS2-IO nanocomposites, which are then modified with two types of polyethylene glycol (PEG) to acquire enhanced stability in physiological environments. Interestingly, (64)Cu, a commonly used positron-emitting radioisotope, could be firmly adsorbed on the surface of MoS2 without the need of chelating molecules, to enable in vivo positron emission tomography (PET) imaging. On the other hand, the strong near-infrared (NIR) and superparamagnetism of MoS2-IO-PEG could also be utilized for photoacoustic tomography (PAT) and magnetic resonance (MR) imaging, respectively. Under the guidance by such triple-modal imaging, which uncovers efficient tumor retention of MoS2-IO-(d)PEG upon intravenous injection, in vivo photothermal therapy is finally conducted, achieving effective tumor ablation in an animal tumor model. Our study highlights the promise of constructing multifunctional theranostic nanocomposites based on 2D transitional metal dichalcogenides for multimodal imaging-guided cancer therapy.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou, Jiangsu 215123, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.forename: Sixiang
authors.initials: S
authors.lastname: Shi
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.forename: Sida
authors.initials: S
authors.lastname: Shen
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Song
authors.forename: Shreya
authors.initials: S
authors.lastname: Goel
authors.forename: Todd E
authors.initials: TE
authors.lastname: Barnhart
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018011:Chalcogens / Q000737:chemistry; D003301:Copper Radioisotopes / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D007553:Isotope Labeling; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D008982:Molybdenum / Q000737:chemistry*; D064847:Multimodal Imaging; D049329:Nanostructures / Q000737:chemistry*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry*; D049268:Positron-Emission Tomography; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D018011:Chalcogens; D003301:Copper Radioisotopes; D004220:Disulfides; D005290:Ferric Compounds; C000499:ferric oxide; D011092:Polyethylene Glycols; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: MoS2 nanosheets; chelate-free 64Cu labeling; iron oxide nanoparticles; multimodal imaging; photothermal therapy