title: Combined influence of teichoic acids from Staphylococcus aureus and heterometallik Cu/Cd ethylenediamine complex on peritoneal macrophages and tumor cells.
abstract: We investigated the effects of teichoic acid (TA) from Staphylococcus aureus Wood 46 on tumor growth and metastasis of the experimental Lewis lung carcinoma (LLC) in mice. Intranasal administration of TA alone aggravated both tumor growth and metastasis, whereas combined administration of TA with a synthetic bimetallic (copper : cadmium) ethylene diamine complex PO244 resulted in pronounced antitumor and antimetastatic effects. The group of animals subjected to the combined treatment with TA and PO244 manifested the highest degree of lymphocyte infiltration into the tumor tissue, compared to the control group and those exposed to TA or PO244 alone. Moreover, the combined treatment negatively affected the adhesive properties of peritoneal macrophages in the LLC bearing mice. Co-cultivation of the isolated macrophages with primary LLC cultures revealed significant (p < 0.05) cytotoxic and cytostatic effects, detected as an increased level of apoptosis and a reduced fraction of replicating cells.
authors.forename: V V
authors.initials: VV
authors.lastname: Nikulina
authors.forename: L V
authors.initials: LV
authors.lastname: Garmanchuk
authors.forename: N V
authors.initials: NV
authors.lastname: Senchylo
authors.forename: T V
authors.initials: TV
authors.lastname: Nikolaenko
authors.forename: O I
authors.initials: OI
authors.lastname: Dzhus
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.forename: N M
authors.initials: NM
authors.lastname: Khranovska
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002104:Cadmium / Q000737:chemistry; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D018920:Coculture Techniques; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D005029:Ethylenediamines / Q000737:chemistry; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000473:pathology; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D061251:Primary Cell Culture; D013211:Staphylococcus aureus / Q000737:chemistry*; D013682:Teichoic Acids / Q000008:administration & dosage; D014407:Tumor Cells, Cultured
chemical_list: D056831:Coordination Complexes; D005029:Ethylenediamines; D013682:Teichoic Acids; D002104:Cadmium; D003300:Copper