title: Phagocytic index of neutrophil granulocytes and monocytes in healthy and preeclamptic pregnancy.
abstract: Neutrophil granulocytes and monocytes have been intensively studied, but there is no scientific data on one of their most important functions, namely the phagocyte function in pregnancy and preeclampsia. The aim of this study was to examine this function. Twenty-five healthy pregnant, 25 preeclamptic pregnant, and 20 healthy, non-pregnant women were enrolled into our study. Cells were isolated from peripheral blood samples, marked and evaluated for the phagocytic index with an immunofluorescent microscope after phagocytosing the zymosan molecules. The phagocytic function of monocytes and neutrophil granulocytes decreased significantly in healthy pregnancy compared with non-pregnant women and in preeclampsia, and it decreased significantly compared with healthy pregnancy. Decreased phagocytic function in healthy pregnancy can be a part of the maternal immunosuppression, which is essential for the protection of the hemiallograft fetus. Further reduction of phagocytic function may be one of the immunoregulatory abnormalities found in preeclampsia.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary. Electronic address: rudolflampe@msn.com.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lampé
authors.affiliation: Departments of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Kövér
authors.affiliation: Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Szűcs
authors.affiliation: Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Pál
authors.affiliation: Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: Ervin
authors.initials: E
authors.lastname: Árnyas
authors.affiliation: Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: Róza
authors.initials: R
authors.lastname: Ádány
authors.affiliation: Departments of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary.
authors.forename: Robert
authors.initials: R
authors.lastname: Póka
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010587:Phagocytosis; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy
keywords: Monocyte; Neutrophil granulocyte; Phagocytic function; Preeclampsia; Pregnancy