title: Influence of social cognition on daily functioning in schizophrenia: study of incremental validity and mediational effects.
abstract: While the role of impaired neurocognition in accounting for functional outcome in schizophrenia is generally established, the influence of social cognition on this relationship is far from clear. This study aims to explore in depth the nature of the relationship between neurocognition, social cognition and daily functioning in people with schizophrenia. Twenty-one individuals diagnosed with schizophrenia and 15 controls completed the assessment of symptom severity, neuropsychological status, social cognition (Theory of Mind and affect processing) and other functional measures. A statistical mediation model based on hierarchical regression analyses was used to establish the mediation path with significant variables. Social cognition played a mediating role between neurocognition and functioning, accounting for significant trends in incremental variance in specific functional indexes (interpersonal behavior and employment/occupation). Consequently, this study adds to the evidence underlining the importance of targeting not only social cognitive or neurocognitive functions but to combine both interventions to reveal the best daily functioning results in schizophrenia patients.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, C/ Casanova 143, 08036 Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), C/ Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Martínez-Domínguez
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, C/ Casanova 143, 08036 Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), C/ Villarroel 170, 08036 Barcelona, Spain; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Department of Psychiatry and Psychology, Clinical Institute of Neurosciences (ICN), Hospital Clinic, C/ Villarroel 170, 08036 Barcelona, Spain. Electronic address: rpenades@clinic.ub.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Penadés
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, C/ Casanova 143, 08036 Barcelona, Spain.
authors.forename: Bàrbara
authors.initials: B
authors.lastname: Segura
authors.affiliation: Department of Psychiatry and Psychology, Clinical Institute of Neurosciences (ICN), Hospital Clinic, C/ Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Alexandre
authors.initials: A
authors.lastname: González-Rodríguez
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, C/ Casanova 143, 08036 Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), C/ Villarroel 170, 08036 Barcelona, Spain; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Department of Psychiatry and Psychology, Clinical Institute of Neurosciences (ICN), Hospital Clinic, C/ Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Catalán
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000503:physiopathology*; D012720:Severity of Illness Index; D012938:Social Perception; D056345:Theory of Mind / Q000502:physiology*
keywords: Emotion recognition; Functioning; Mediation; Neurocognition; Schizophrenia; Theory of Mind