title: A clinical analysis of brain metastasis in gynecologic cancer: a retrospective multi-institute analysis.
abstract: This study analyzes the clinical characteristics of the brain metastasis (BM) of gynecologic cancer based on the type of cancer. In addition, the study examines the factors influencing the survival. Total 61 BM patients of gynecologic cancer were analyzed retrospectively from January 2000 to December 2012 in terms of clinical and radiological characteristics by using medical and radiological records from three university hospitals. There were 19 (31.1%) uterine cancers, 32 (52.5%) ovarian cancers, and 10 (16.4%) cervical cancers. The mean interval to BM was 25.4 months (21.6 months in ovarian cancer, 27.8 months in uterine cancer, and 33.1 months in cervical cancer). The mean survival from BM was 16.7 months (14.1 months in ovarian cancer, 23.3 months in uterine cancer, and 8.8 months in cervical cancer). According to a multivariate analysis of factors influencing survival, type of primary cancer, Karnofsky performance score, status of primary cancer, recursive partitioning analysis class, and treatment modality, particularly combined therapies, were significantly related to the overall survival. These results suggest that, in addition to traditional prognostic factors in BM, multiple treatment methods such as neurosurgery and combined chemoradiotherapy may play an important role in prolonging the survival for BM patients of gynecologic cancer.
authors.affiliation: Division of Neurooncology, Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Young Zoon
authors.identifier: 0000-0001-9724-3081
authors.initials: YZ
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Jae Hyun
authors.identifier: 0000-0002-1507-0082
authors.initials: JH
authors.lastname: Kwon
authors.affiliation: Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Soyi
authors.identifier: 0000-0001-8886-3107
authors.initials: S
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000401:mortality* / Q000556:secondary* / Q000628:therapy; D059248:Chemoradiotherapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D055815:Young Adult
keywords: Brain Metastasis; Ovarian Neoplasm; Uterine Cervical Neoplasm; Uterine Neoplasm, Outcome