title: Leptin and leptin receptor polymorphisms are related to body mass index in a Turkish population.
abstract: OBJECTIVE
  Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels and leptin receptor polymorphisms in a Turkish population.
  
  
  METHODS
  The sample pool of this study consisted of 202 subjects. G2548A variant in the promoter region of the leptin gene and Q223R polymorphism of the leptin receptor gene were evaluated by using PCR-RFLP. Leptin levels were determined by ELISA.
  
  
  RESULTS
  Leptin levels were significantly higher in subjects with the A allele than in subjects without the A allele. Leptin receptor levels were lower in subjects with the AA genotype than in those with the AG genotype. There was a higher prevalence of the leptin-2548 AA genotype among subjects with a BMI ≥ 25 kg/m2 than in those with a BMI < 25 kg/m2.
  
  
  CONCLUSIONS
  The leptin-2548A allele might be a predisposing factor for obesity.
authors.forename: Uzay
authors.initials: U
authors.lastname: Görmüş
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Tımırcı Kahraman
authors.forename: Bahar
authors.initials: B
authors.lastname: Toptaş
authors.forename: Turgay
authors.initials: T
authors.lastname: İsbır
authors.forename: Çavlan
authors.initials: Ç
authors.lastname: Çıftçı
authors.forename: Hasan Hakan
authors.initials: HH
authors.lastname: Berkkan
authors.forename: Altay Burak
authors.initials: AB
authors.lastname: Dalan
authors.forename: Mutia Canan
authors.initials: MC
authors.lastname: Karatay
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D054411:Receptors, Leptin / Q000235:genetics*; D014421:Turkey; D055815:Young Adult
chemical_list: D020738:Leptin; D054411:Receptors, Leptin