title: Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.
abstract: F box only protein 8 (FBX8) is a novel component of F-box proteins which involved in the ubiquitin-dependent proteolytic pathway. Recent studies have revealed that FBX8 was unregulated in tumor cells and was closely associated with tumor progression and metastasis of other cancer, but little research has been done yet to test its usefulness as a prognostic marker in human glioma. In the present study, we investigated the expression of FBX8 in glioma tissues using immunohistochemical analysis and evaluated its prognostic significance in glioma. We found that 44/77 (57.14%) gilomas had positive expression of FBX8, while 65/77 (84.42%) normal brain tissue had positive expression of FBX8. The expression level of FBX8 was remarkably down-regulated in glioma tissues compared with normal brain tissues (P < 0.001). The down-expression of FBX8 in tumor cells was strongly correlated with tumor grade of patients with glioma (P < 0.05). Patients with lower expression of FBX8 protein had shorter overall survival time than those with higher level expression of FBX8 (P < 0.05). Multivariate analysis showed that FBX8 down-expression was an independent prognostic indicator for glioma patient's survival. Our results suggest that a potential application of FBX8 in prognosis prediction and therapeutic application in glioma.
authors.affiliation: Department of Neurosurgery, The First Hospital, Jilin University Changchun 130021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, China-Japan Union Hospital, Jilin University Changchun 130033, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Sun
authors.affiliation: Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University Beijing 100015, China.
authors.forename: Na
authors.initials: N
authors.lastname: Ren
authors.affiliation: Department of Neurosurgery, The First Hospital, Jilin University Changchun 130021, China.
authors.forename: Yunqian
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Plastic and Aesthetic Surgery, The First Hospital, Jilin University Changchun 130021, China.
authors.forename: Li
authors.initials: L
authors.lastname: Rong
authors.affiliation: Department of Neurosurgery, The First Hospital, Jilin University Changchun 130021, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002648:Child; D015536:Down-Regulation; D044783:F-Box Proteins / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D044783:F-Box Proteins; C555947:FBXO8 protein, human
keywords: F box only protein 8; glioma; prognosis; tumor grade