title: Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?
abstract: OBJECTIVE
  Inflammation plays an important role in acute ischemic stroke. In this study we aimed to investigate the relationship between acute ischemic stroke and serum amyloid A, fetuin-A, and pentraxin-3 which are inflammation markers.
  
  
  METHODS
  We enrolled 52 patients with acute ischemic stroke and 30 sex-matched control subjects in the study. The patients were followed for 3 months. We evaluated the common risk factors, laboratory variables, and neurological examination of stroke patients according to prognosis scales.
  
  
  RESULTS
  The median serum amyloid A, fetuin-A, and pentraxin-3 levels in the stroke patients were higher than in control subjects (respectively, P = 0.000, P = 0.002, and P = 0.037). National Institutes of Health Stroke Scale scores, glucose, C-reactive protein, fibrinogen, and white blood cell count showed differences within the group in terms of the serum amyloid A tertiles statistically.
  
  
  CONCLUSIONS
  Pentraxin-3, fetuin-A, and serum amyloid A all arise together as novel prognostic factors in a group of patients with ischemic stroke. Relationships between higher levels of inflammation markers, especially serum amyloid A, and the severity of acute ischemic stroke were shown.
authors.affiliation: Department of Biochemistry, Ankara Numune Training and Research Hospital, Turkey. sevilaysezer@gmail.com
authors.forename: Sevilay
authors.initials: S
authors.lastname: Sezer
authors.forename: Fatma
authors.initials: F
authors.lastname: Uçar
authors.forename: Ersin Kasim
authors.initials: EK
authors.lastname: Ulusoy
authors.forename: Serpil
authors.initials: S
authors.lastname: Erdogan
authors.forename: Sule
authors.initials: S
authors.lastname: Bilen
authors.forename: Cevdet
authors.initials: C
authors.lastname: Züngün
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.forename: Haci Kemal
authors.initials: HK
authors.lastname: Erdemli
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000032:analysis*; D000683:Serum Amyloid P-Component / Q000032:analysis*; D020521:Stroke / Q000097:blood*; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000685:Serum Amyloid A Protein; D000683:Serum Amyloid P-Component; D060749:alpha-2-HS-Glycoprotein; D000099153:Pentraxins