title: Microfluidic platform towards point-of-care diagnostics in infectious diseases.
abstract: Rapid and timely diagnosis of infectious diseases is a critical determinant of clinical outcomes and general public health. For the detection of various pathogens, microfluidics-based platforms offer many advantages, including speed, cost, portability, high throughput, and automation. This review provides an overview of the recent advances in microfluidic technologies for point-of-care (POC) diagnostics for infectious diseases. The key aspects of such technologies for the development of a fully integrated POC platform are introduced, including sample preparation, on-chip nucleic acid analysis and immunoassay, and system integration/automation. The current challenges to practical implementation of this technology are discussed together with future perspectives.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Su
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen 518057, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Gao
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: jhqin@dicp.ac.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qin
mesh_terms: D003141:Communicable Diseases / Q000175:diagnosis*; D019937:Diagnostic Techniques and Procedures / Q000295:instrumentation*; D006801:Humans; D007118:Immunoassay; D044085:Microfluidics; D019095:Point-of-Care Systems
keywords: Immunoassay; Infectious disease; Microfluidic; Nucleic acid analysis; Point-of-care testing