title: A survey of tremetone, dehydrotremetone, and structurally related compounds in Isocoma spp. (goldenbush) in the southwestern United States.
abstract: Isocoma pluriflora, a plant prevalent on land used for livestock production and native to Arizona, New Mexico, West Texas, and Northern Mexico, is poisonous and causes trembles in livestock. Tremetone and dehydrotremetone have been suggested as the toxic compounds in I. pluriflora. In this study several different Isocoma spp., including I. pluriflora, I. tenuisecta, I. azteca, I. acradenia, and I. rusbyi, that are native to land used for grazing livestock in the southwestern United States were analyzed by high performance liquid chromatography (HPLC) for tremetone, dehydrotremetone, and other structurally related compounds. This is the first report of tremetone, dehydrotremetone, and 3-oxyangeloyltremetone in I. tenuisecta, I. azteca, I. acradenia, I. rusbyi, and several other Isocoma spp. In addition, this is the first report of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone and 7-isopentenyloxycoumarin in Isocoma spp.
authors.affiliation: Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture , 1150 East 1400 North, Logan, Utah 84341, United States.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Lee
authors.forename: Daniel
authors.initials: D
authors.lastname: Cook
authors.forename: T Zane
authors.initials: TZ
authors.lastname: Davis
authors.forename: Dale R
authors.initials: DR
authors.lastname: Gardner
authors.forename: Robert L
authors.initials: RL
authors.lastname: Johnson
authors.forename: Clinton A
authors.initials: CA
authors.lastname: Stonecipher
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001572:Benzofurans / Q000032:analysis* / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D058751:Livestock; D009682:Magnetic Resonance Spectroscopy; D010939:Plant Poisoning / Q000209:etiology / Q000662:veterinary; D015206:Southwestern United States
chemical_list: D001572:Benzofurans; C000602910:dehydrotremetone; C000602909:tremetone
keywords: Isocoma acradenia; Isocoma azteca; Isocoma pluriflora; Isocoma rusbyi; Isocoma tenuisecta; dehydrotremetone; tremetone