title: Association of Serum Levels of Adipocyte Fatty Acid-Binding Protein and High-Sensitivity C Reactive Protein with Severity of Acute Ischemic Stroke.
abstract: To evaluate the serum levels of adipocyte fatty acid-binding protein (A-FABP) and high-sensitivity C reactive protein (hs-CRP) in patients with acute ischemic stroke (AIS), and correlations among A-FABP, hs-CRP, and AIS, 108 patients with AIS and 86 healthy controls were examined. The levels of hs-CRP and A-FABP were detected by ELISAs. The stroke severity was determined using the modified Rankin scale (mRS). Patients with AIS were divided into those with mild (mRS ≤ 3) and severe disease (mRS > 3). Regression analysis was performed to test association between hs-CRP and A-FABP. Serum levels of hs-CRP and A-FABP were significantly higher in patients with AIS compared with healthy controls. Furthermore, more severe AIS was associated with higher levels of these markers. Regression analysis demonstrated a weak but significant association between A-FABP and hs-CRP. A-FABP and hs-CRP are associated with AIS, and may be involved in the pathogenesis of AIS.
authors.affiliation: Department of Nuclear Medicine, Xuzhou Central Hospital, 199# Liberation Road S. Road, Xuzhou, 221009, China. 18952171648@163.com.
authors.forename: Xiang-Lei
authors.initials: XL
authors.lastname: Huang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002545:Brain Ischemia / Q000097:blood* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D002097:C-Reactive Protein
keywords: A-FABP; Acute ischemic stroke; hs-CRP