title: Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans.
abstract: Fullerene derivatives have attracted extensive attention in biomedical fields and polyhydroxyl fullerene (fullerenol), a water-soluble fullerene derivative, is demonstrated as a powerful antioxidant. To further assess their anti-aging and anti-stress potential, we employed Caenorhabditis elegans (C. elegans) as a model organism to evaluate the effects of fullerenol on the growth, development, behavior and anti-stress ability in vivo. The data show that fullerenol has no obviously toxic effect on nematodes and can delay C. elegans aging progress under normal condition. Further studies demonstrate that fullerenol attenuates endogenous levels of reactive oxygen species and provides protection to C. elegans under stress conditions by up-regulating stress-related genes in a DAF-16 depend manner and improving lifespan. In summary, our data suggest that fullerenol might be a safe and reasonable anti-aging candidate with great potential in vivo.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Wenshu
authors.initials: W
authors.lastname: Cong
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Tang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Bai
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China. Electronic address: chenchy@nanoctr.cn.
authors.lastname: Chunying Chen
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian 116044, China. Electronic address: bixl@dlmedu.edu.cn.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Bi
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D005453:Fluorescence; D016166:Free Radical Scavengers / Q000494:pharmacology; D037741:Fullerenes / Q000494:pharmacology* / Q000633:toxicity; D007422:Intestines / Q000187:drug effects / Q000502:physiology; D008062:Lipofuscin / Q000378:metabolism; D008136:Longevity / Q000187:drug effects; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects* / Q000235:genetics; D018675:Toxicity Tests; D014158:Transcription, Genetic / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D029742:Caenorhabditis elegans Proteins; D016166:Free Radical Scavengers; D037741:Fullerenes; D008062:Lipofuscin; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; C108127:fullerenol
keywords: Anti-aging; Caenorhabditis elegans; DAF-16; Fullerenol; Insulin/IGF-1 pathway; Lifespan