title: Remission of type 2 diabetes after omega loop gastric bypass for morbid obesity.
abstract: BACKGROUND
  Roux-en-Y gastric bypass (RYGBP) is a validated technique for the treatment of morbid obesity and results in a significant rate of remission of type 2 diabetes (T2D). Omega gastric bypass (OGBP) is an effective and simpler alternative for weight loss, but its effect on T2D is unclear.
  
  
  METHODS
  Between December 2006 and September 2012, 804 laparoscopic OGBPs were carried out in our centre. Among these, 100 (12.4%) patients had T2D at the time of the intervention. Remission of T2D was defined by a glycated haemoglobin (HbA1c) level of <6% without concomitant treatment.
  
  
  RESULTS
  Postoperative follow-up was completed by 81 patients (mean age: 49 ± 11 years; mean weight at surgery: 133 ± 29 kg; mean body mass index (BMI): 47 ± 9 kg/m(2)). Mean preoperative HbA1c was 8 ± 2 g/dL. Before OGBP, seven patients (9%) had received no oral hypoglycaemic treatment, 30 (37%) had received monotherapy, 26 (32%) bitherapy, six (7%) tritherapy and 12 (15%) patients had used insulin. Over a mean follow-up of 26 months (range 1-75), mean weight decreased to 94 ± 23 kg and mean BMI to 35 kg/m(2). Seventy-one (88%) patients had complete remission of T2D and the other 10 (12%) had reduced their treatment. Seven patients (58%) initially treated with insulin no longer required this treatment. Mean time to remission of T2D for patients receiving one or more oral therapies versus insulin was 6.9 versus 17.9 months.
  
  
  CONCLUSIONS
  OMBP is effective treatment for obesity in terms of weight loss and remission of T2D.
authors.affiliation: Department of Digestive Surgery, Hôpital Européen Georges Pompidou, Paris, France, martino.guenzi@gmail.com.
authors.forename: Martino
authors.initials: M
authors.lastname: Guenzi
authors.forename: Gustavo
authors.initials: G
authors.lastname: Arman
authors.forename: Cédric
authors.initials: C
authors.lastname: Rau
authors.forename: Cristiana
authors.initials: C
authors.lastname: Cordun
authors.forename: David
authors.initials: D
authors.lastname: Moszkowicz
authors.forename: Thibault
authors.initials: T
authors.lastname: Voron
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Chevallier
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000379:methods*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D012074:Remission Induction; D012189:Retrospective Studies; D015431:Weight Loss
chemical_list: D006442:Glycated Hemoglobin