title: [Status and advances of RGD molecular imaging in lung cancer].
abstract: Lung cancer has been one of the most common and the highest mortality rates malignant tumors at home and abroad. Sustained angiogenesis was not only the characteristic of malignant tumors, but also the foundation of tumor proliferation, invasion, recurrence and metastasis, it was also one of the hot spots of treatments in lung cancer biology currently. Integrins played an important part in tumor angiogenesis. Arg-Gly-Asp (RGD) peptides could combine with integrins specifically, and the application of radionuclide-labeled RGD molecular probes enabled imaging of tumor blood vessels to reflect its changes. The lung cancer imaging of RGD peptides at home and abroad in recent years was reviewed in this article.
authors.affiliation: Department of Nuclear Medicine, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Yue
authors.affiliation: Department of Nuclear Medicine, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China.
authors.forename: Shuanghu
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Nuclear Medicine, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China.
authors.forename: Guoren
authors.initials: G
authors.lastname: Yang
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D009842:Oligopeptides
chemical_list: D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid