title: Annual banned-substance review: analytical approaches in human sports drug testing.
abstract: Within the mosaic display of international anti-doping efforts, analytical strategies based on up-to-date instrumentation as well as most recent information about physiology, pharmacology, metabolism, etc., of prohibited substances and methods of doping are indispensable. The continuous emergence of new chemical entities and the identification of arguably beneficial effects of established or even obsolete drugs on endurance, strength, and regeneration, necessitate frequent and adequate adaptations of sports drug testing procedures. These largely rely on exploiting new technologies, extending the substance coverage of existing test protocols, and generating new insights into metabolism, distribution, and elimination of compounds prohibited by the World Anti-Doping Agency (WADA). In reference of the content of the 2014 Prohibited List, literature concerning human sports drug testing that was published between October 2013 and September 2014 is summarized and reviewed in this annual banned-substance review, with particular emphasis on analytical approaches and their contribution to enhanced doping controls.
authors.affiliation: Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany; European Monitoring Center for Emerging Doping Agents, Cologne, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Thevis
authors.forename: Tiia
authors.initials: T
authors.lastname: Kuuranne
authors.forename: Hans
authors.initials: H
authors.lastname: Geyer
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Schänzer
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000032:analysis / Q000493:pharmacokinetics; D045930:Anabolic Agents / Q000032:analysis / Q000493:pharmacokinetics; D000818:Animals; D002186:Cannabinoids / Q000032:analysis / Q000493:pharmacokinetics; D004300:Doping in Sports / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000493:pharmacokinetics; D013058:Mass Spectrometry / Q000379:methods; D036361:Peptide Hormones / Q000032:analysis / Q000493:pharmacokinetics; D058573:Performance-Enhancing Substances / Q000032:analysis* / Q000493:pharmacokinetics; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D045930:Anabolic Agents; D002186:Cannabinoids; D036341:Intercellular Signaling Peptides and Proteins; D036361:Peptide Hormones; D058573:Performance-Enhancing Substances
keywords: cobalt; gene doping; mass spectrometry; sport; xenon