title: [Development of targeted drug delivery system: synthesis of conjugates of address fragment (RA-COOH) with ligand (R-NH2)].
abstract: One of the main ways to increase the effectiveness of well-known medical formulations well-established in clinical medicine - development of delivery systems using new technological approaches and nanomaterials. Currently, much attention is given to targeted delivery systems. At the same time drug carrier has in addition to medication the so-called vector/address with a high affinity for binding to specific receptors on cells/tissue target. In this paper it is described the method for producing of address conjugates to over-expressed receptors on the tumor cells. As address fragment it was folic acid and as a linker was dodecylamine, causing inclusion the conjugate into lipid nanoparticles.
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: M A
authors.initials: MA
authors.lastname: Sanzhakov
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: D V
authors.initials: DV
authors.lastname: Ignatov
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: V N
authors.initials: VN
authors.lastname: Prozorovskiĭ
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: O S
authors.initials: OS
authors.lastname: Druzhilovskaia
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.affiliation: Institute of Biomedical Chemistry.
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
mesh_terms: D000588:Amines / Q000737:chemistry*; D001692:Biological Transport; D004337:Drug Carriers / Q000138:chemical synthesis*; D005022:Ethyldimethylaminopropyl Carbodiimide / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000588:Amines; D004337:Drug Carriers; D005492:Folic Acid; D005022:Ethyldimethylaminopropyl Carbodiimide; C003935:dodecylamine
keywords: amid bond; dodecylamine; folic acid; oncology; targeted delivery system