title: Histone storage and deposition in the early Drosophila embryo.
abstract: Drosophila development initiates with the formation of a diploid zygote followed by the rapid division of embryonic nuclei. This syncytial phase of development occurs almost entirely under maternal control and ends when the blastoderm embryo cellularizes and activates its zygotic genome. The biosynthesis and storage of histones in quantity sufficient for chromatin assembly of several thousands of genome copies represent a unique challenge for the developing embryo. In this article, we have reviewed our current understanding of the mechanisms involved in the production, storage, and deposition of histones in the fertilized egg and during the exponential amplification of cleavage nuclei.
authors.affiliation: Centre de Génétique et de Physiologie Moléculaire et Cellulaire-CNRS UMR5534, Université Claude Bernard Lyon 1, University of Lyon, 69100, Villeurbanne, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Horard
authors.forename: Benjamin
authors.initials: B
authors.lastname: Loppin
mesh_terms: D000818:Animals; D001756:Blastoderm / Q000196:embryology; D002467:Cell Nucleus / Q000235:genetics; D002503:Centromere / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D004261:DNA Replication; D004330:Drosophila / Q000196:embryology* / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D023281:Genomics; D006657:Histones / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism; D015053:Zygote / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D006657:Histones; D009707:Nucleosomes