title: The impact of operative timing on outcomes of appendicitis: a National Surgical Quality Improvement Project analysis.
abstract: BACKGROUND
  Surgery is indicated for acute uncomplicated appendicitis but the optimal timing is controversial. Recent literature is conflicting on the effect of time to intervention.
  
  
  METHODS
  We queried the American College of Surgeons National Surgical Quality Improvement Project dataset for patients undergoing laparoscopic and open appendectomy between 2007 and 2012. Logistic regression was used to evaluate 30-day morbidity and mortality of intervention at different time periods, adjusting for preoperative risk factors.
  
  
  RESULTS
  A total of 69,926 patients undergoing appendectomy were identified. Groups were divided by time to intervention: group 1, less than 24 hours (n = 55,839; 79.9%); group 2, 24 to 48 hours (n = 13,409; 18.6%); and group 3, greater than 48 hours (n = 1,038; 1.5%). After adjustment, the risk of complication remained increased for group 3 versus group 1 or 2 (odds ratio 1.66, 95% confidence interval 1.34 to 2.07).
  
  
  CONCLUSIONS
  These data demonstrate equivalent outcomes between time to appendectomy of less than 24 and 24 to 48 hours. There was a 2-fold increase in complication rate for patients delayed longer than 48 hours.
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Fair
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Kubasiak
authors.affiliation: Department of Preventative Medicine, Triangle Office Building, Suite 470, Rush Graduate College, 1700 W. Van Buren Street, Chicago, IL 60612, USA.
authors.forename: Imke
authors.initials: I
authors.lastname: Janssen
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Myers
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Millikan
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Deziel
authors.affiliation: Department of General Surgery, Professional Building, Suite 810, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA. Electronic address: Minh_B_Luu@rush.edu.
authors.forename: Minh B
authors.initials: MB
authors.lastname: Luu
mesh_terms: D000328:Adult; D000368:Aged; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D010535:Laparoscopy; D007902:Length of Stay / Q000639:trends; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D061646:Operative Time; D011183:Postoperative Complications / Q000453:epidemiology*; D058996:Quality Improvement / Q000458:organization & administration*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome
keywords: Laparoscopic appendectomy; NSQIP; Open appendectomy