title: Human papilloma virus vaccination: impact and recommendations across the world.
abstract: Human papilloma virus (HPV) vaccination has been implemented in several countries for about the past 7 years, mainly in the adolescent female population, with varying coverage results. Although the impact of immunization on cervical and other HPV-related cancers will be evident in the next decades, a marked decrease of prevalent HPV infections, precancerous lesions and genital warts is already dramatic in the vaccinated cohorts, and also in their sexual partners, thus providing clear evidence of the effectiveness of HPV vaccination, including a herd-protection effect. Today, recommendations and implementation of universal HPV vaccination for adolescent girls are a public-health priority in all countries of the world. Countries with limited resources are presently involved in demonstration projects and, in some cases, have launched national programmes with the help of international agencies and alliances. Extension of immunization offer to young women and to adolescent male subjects has become an important additional opportunity for several countries, with a special focus needed on homosexual men with HIV infection who are at particularly increased risk of HPV-related diseases. Public-health authorities are confronted with the need to enlarge HPV-vaccination offer to all target groups, especially pre-adolescent girls, so that they can be saved from dreadful cancers by reaching high immunization coverage.
authors.affiliation: Department of Health Sciences, University of Florence, Viale G.B. Morgagni 48, 50134 Florence, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonanni
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Bechini
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Donato
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Capei
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Sacco
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Miriam
authors.initials: M
authors.lastname: Levi
authors.affiliation: Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Boccalini
keywords: coverage; human papilloma virus; impact; recommendations; vaccination