title: Morbidity pattern of non-cancer endocrine disease in ChNPP accident emergency workers (1992-2013 Clinical/Epidemiological Registry data).
abstract: Objective. The study examined the morbidity pattern of non-cancer endocrine disease in ChNPP accident emergency workers (AEW) versus the entire population of Ukraine. Materials and methods. The study included a retrospective estimation of the examination data from 10,771 ChNPP AEW of the so-called iodine and non-iodine periods (main study group). Data were received from the RCRM Clinical/Epidemiological Registry for the survey period of 22 years (1992-2013) on persons been either healthy or having a range of endocrine disease. Anthropometric measures both with biochemical and hormonal assay data and external radiation dose values were taken into account. Diagnostic thyroid ultrasound was applied. Results. There is a significant (2-10-fold) and reliable (p < 0.01) increase of the incidence of non-cancer endocrine disease in the ChNPP AEW, namely by 23.20 % of nodular goiter (0.53 % in control, χ2 = 9602, р < 0.0001), by 13.37 % of autoimmune thyroiditis (0.35 % in control; χ2 = 5381, р < 0.0001), by 11.89 % in average and by 16.29 % in last years of type 2 diabetes mellitus (χ2 = 2527, р < 0.0001), by 41.67 % of pre-obesity (χ2 = 10.92, р < 0.01), and by 38.12 % of obesity (χ2 = 41.50, р < 0.01) compared to the entire population. Conclusions. Effects of ionizing radiation and other hazardous factors on endocrine system in the ChNPP AEW appeared upon 15-25 years. There was a significant (2-10-fold) and reliable (p < 0.01) increase of the incidence of the nodular goiter, autoimmune thyroiditis, obesity, type 2 diabetes mellitus. And there is a trend to further increase.
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine. vkpand@ukr.net.
authors.forename: O V
authors.initials: OV
authors.lastname: Kaminskiy
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine. vkpand@ukr.net.
authors.forename: O V
authors.initials: OV
authors.lastname: Pronin
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine. vkpand@ukr.net.
authors.forename: D E
authors.initials: DE
authors.lastname: Afanasyev
keywords: ChNPP accident; accident emergency workers; diabetes mellitus; endocrine system; ionizing radiation; obesity; thyroid