title: Antihematotoxic Role of Bunium persicum Seed Differential Extracts in Animal Model: Reactive Oxygen Species Might Be a Contributor.
abstract: OBJECTIVE
  Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. persicum against leukemic blood induced hematotoxicity in an animal model.
  
  
  METHODS
  This study was performed on animals, which were divided into several groups: normal control, disease control, and groups that were administered with differential extracts of plants. We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.
  
  
  RESULTS
  The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. persicum extract and the normal group. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.
  
  
  CONCLUSIONS
  These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B. persicum against ROS-induced hematotoxicity.
authors.affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Tahir
authors.initials: T
authors.lastname: Ali
authors.affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Kamran
authors.initials: K
authors.lastname: Saeed
authors.affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abdullah
authors.affiliation: Signal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Iram
authors.initials: I
authors.lastname: Murtaza
keywords: Bunium persicum; ROS; hematotoxicity