title: A 90-day study of three bruchid-resistant mung bean cultivars in Sprague-Dawley rats.
abstract: Mung bean has been traditionally and widely used as an edible and medicinal plant in the South and Southeast Asia. Bruchid resistance mung bean has more potential in commercial use, but scarcely been evaluated for safety through standard in vivo toxicological studies. In the present study, subchronic oral toxicity studies of bruchid-resistant mung bean were designed and conducted in Sprague-Dawley (SD) rats for 90 days. During the subchronic oral toxicity study, no mortality and toxicologically significant changes in clinical signs, food consumption, opthalmoscopic examination, hematology, clinical biochemistry, macroscopic findings, organ weights and histopathological examination were noted in animal administered diet containing bruchid-resistant mung bean. These results demonstrated that bruchid resistant mung bean is as safe as conventional mung bean.
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address: renguixing@caas.cn.
authors.forename: Guixing
authors.initials: G
authors.lastname: Ren
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D001517:Coleoptera; D004906:Erythrocyte Count; D007887:Fabaceae / Q000737:chemistry* / Q000469:parasitology*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009885:Ophthalmology; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism; D059550:Toxicity Tests, Subchronic; D016482:Urinalysis
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
keywords: 90-day subchronic toxicity; Bruchid-resistant; Mung bean; Safety assessment