title: Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women.
abstract: OBJECTIVE
  To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease.
  
  
  METHODS
  This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population.
  
  
  RESULTS
  Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group.
  
  
  CONCLUSIONS
  Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.
authors.affiliation: Department of Obstetrics and Gynecology,  Turgut Özal University, Ankara, Turkey. ikbal_cekmen@yahoo.com
authors.forename: İkbal
authors.initials: İ
authors.lastname: Kaygusuz
authors.forename: Serap Aynur
authors.initials: SA
authors.lastname: Simavli
authors.forename: Ayla
authors.initials: A
authors.lastname: Eser
authors.forename: Ilknur
authors.initials: I
authors.lastname: Inegöl Gümüş
authors.forename: Selcen
authors.initials: S
authors.lastname: Yüksel
authors.forename: Zehra Candan
authors.initials: ZC
authors.lastname: Iltemir Duvan
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafali
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D063847:Mean Platelet Volume; D008875:Middle Aged; D017698:Postmenopause; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D008055:Lipids; D002097:C-Reactive Protein