title: Practical route to 2-quinolinones via a Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade reaction.
abstract: Quinolinone derivatives were constructed via a Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade process with simple anilines as the substrates. This finding provides a practical procedure for the synthesis of quinolinone-containing alkaloids and drug molecules. The utility of this method was demonstrated by a formal synthesis of Tipifarnib.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University , 21 Nanyang Link, Singapore 637371.
authors.forename: Junliang
authors.initials: J
authors.lastname: Wu
authors.forename: Shaohua
authors.initials: S
authors.lastname: Xiang
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Minli
authors.initials: M
authors.lastname: Leow
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D015363:Quinolones; D010165:Palladium