title: Effects of resveratrol on doxorubicin induced testicular damage in rats.
abstract: The purpose of this study was to evaluate the likely protective effect of resveratrol (RES) on doxorubicin (DOX) induced testicular damage. Rats were divided into five groups: control, RES, dimethyl sulfoxide (DMSO), DOX and DOX+RES. At the end of treatment, the rats were sacrificed. Plasma testosterone levels, oxidative status, epididymal sperm parameters and testicular apoptosis were evaluated. MDA levels, GP-x and GSH activities were higher in the DOX group than in the control group. MDA levels were lower in the DOX+RES group than in the DOX group. The DOX group exhibited a significant decrease in plasma testosterone levels, sperm concentration and motility, and a significant increase in abnormal sperm rate and TUNEL (+) cells in the testis. A significant increase was observed in plasma testosterone levels and sperm concentration and motility, and a significant decrease in the abnormal sperm rate and TUNEL (+) cells in the DOX+RES group compared to the DOX group. A marked improvement in severe degenerative alterations in the germinative epithelium was also observed following treatment with RES. In conclusion, RES makes a positive contribution to fertility by exhibiting anti-apoptotic and antiperoxidative effects against DOX-induced testicular damage.
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Histology and Embryology, 61080 Trabzon, Turkey. Electronic address: sibelturedi3361@hotmail.com.
authors.forename: Sibel
authors.initials: S
authors.lastname: Türedi
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Histology and Embryology, 61080 Trabzon, Turkey. Electronic address: esinyulug@gmail.com.
authors.forename: Esin
authors.initials: E
authors.lastname: Yuluğ
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Medical Biochemistry, 61080 Trabzon, Turkey. Electronic address: alver61@yahoo.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Urology, 61080 Trabzon, Turkey. Electronic address: omerkutlu@ktu.edu.tr.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Kutlu
authors.affiliation: Karadeniz Technical University, Faculty of Medicine, Department of Medical Biochemistry, 61080 Trabzon, Turkey. Electronic address: cemilce75@mynet.com.
authors.forename: Cemil
authors.initials: C
authors.lastname: Kahraman
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D020287:In Situ Nick-End Labeling; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013267:Stilbenes / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D013267:Stilbenes; D004317:Doxorubicin; D000077185:Resveratrol
keywords: Apoptosis; Doxorubicin; Infertility; Resveratrol; Testicular toxicity