title: Association study of vascular endothelial growth factor gene polymorphisms with ectopic pregnancy in Chinese women.
abstract: OBJECTIVE
  The purpose of this study is to evaluate potential associations between vascular endothelial growth factor (VEGF) gene polymorphisms and ectopic pregnancy (EP) in Chinese women.
  
  
  METHODS
  This was a case-control study wherein 192 women with a history of EP were compared to 210 post-menopausal controls with two pregnancies and no EP for the genotyping of VEGF polymorphisms. Genotyping of the VEGF gene polymorphisms at -460C/T, -1 154G/A, -2578C/A and +936C/T were performed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  No significant differences were found in genotype and allele distributions of the -460C/T, +936C/T polymorphisms between cases and controls. Compared with the -1154G/G genotype, the -1154(A/A+G/A) genotype could significantly reduce the risk of developing EP. For the -2578C/A polymorphism, the A/A+C/A geno- type could significantly decrease the risk of developing EP, compared with the C/C genotype. The haplotype analysis suggested that the TAA (VEGF -460/-1154/-2578) and CAA haplotypes could significantly decrease the risk of developing EP compared with the haplotype of TGC.
  
  
  CONCLUSIONS
  The -1154A or -2578A alleles of VEGF gene could significantly decrease the risk of EP and might be po- tentially protective factors for EP development in Chinese women.
authors.affiliation: Department of Gynecology, Zhujiang Hospital of Southern Medical University, Nanhai District People’s Hospital of Foshan City, China.
authors.forename: D J
authors.initials: DJ
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: H Y
authors.initials: HY
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.forename: P
authors.initials: P
authors.lastname: Du
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A