title: Prepregnancy Maternal Weight and Body Mass Index of Children with and without Congenital Heart Disease.
abstract: OBJECTIVE
  Congenital heart diseases are among the most frequent major congenital anomalies. One of the suspected reasons for congenital heart defects is overweight and obesity of mother during prepregnancy and pregnancy. We studied the relationship between maternal overweight and obesity and the risk of congenital anomaly.
  
  
  METHODS
  All of children with congenital heart defect (164 infants with major nonsyndromic heart disease) referred to our pediatric cardiology clinic or admitted to our ward during 2011-2012 were included in this study. Controls were 158 live-born infants without any major malformations and their mothers. Mothers of these infants were studied for weight, height and body mass index (BMI). Findings : The most frequent congenital heart disease was ventricular septal defect (39%), patent ductus arteriosus (11%), complete atrioventricular septal defect (10%), pulmonary stenosis (9.1%), and atrial septal defect (8.5%). There was no significant difference between maternal age (P=0.1), weight (P=0.8) and height (P=0.3) in the two groups. The mothers had not significantly higher BMI than that of the control mothers. Compared with underweight (BMI <18.5) and normal weight women (OR: 1.24, 95%CI: 0.40-3.89), overweight (OR: 0.98, 95%CI: 0.31-3.10) and obese women (OR: 1.16, 95%CI: 0.34-4.00) were not more likely to have an infant with a congenital heart defect.
  
  
  CONCLUSIONS
  This study suggests that there may not be a relation between maternal BMI and having a child with congenital heart defect.
authors.affiliation: Department of Pediatric Cardiology, Emam Hosein Medical, Educational and Research Center, Esfahan University of Medical Sciences ; Department of Pediatric Cardiology.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ghaderian
authors.affiliation: Department of Pediatric Cardiology.
authors.forename: Abdol-Rahman
authors.initials: AR
authors.lastname: Emami-Moghadam
authors.affiliation: Department of Pediatric Cardiology.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Khalilian
authors.affiliation: Pediatric Endocrinology.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Riahi
authors.affiliation: Golestan Hospital, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ghaedi
keywords: Congenital Heart Defects; Maternal Obesity; Maternal Overweight