title: The use of shear rate-diameter dose-response curves as an alternative to the flow-mediated dilation test.
abstract: The brachial artery flow-mediated dilation test (FMD) is the non-invasive gold-standard used to test endothelial function. Reduced FMD precedes the development of atherosclerosis and provides an early marker for predicting future cardiovascular disease events. Although, this test is of high potential, it is somewhat limited by poor reproducibility. By utilizing hand warming and grip exercise combined with hierarchical linear modeling, shear rate-diameter dose-response curves may provide a novel and more accurate way to assess endothelial function in humans. Shear rate-diameter dose-response curves could potentially improve upon the traditional FMD measurement and serve as a superior clinical and research tool for assessing cardiovascular disease risk in a variety of populations. The current paper presents testable hypotheses and methodology for assessing the validity and reliability of an alternative to the current FMD test.
authors.affiliation: Keck School of Medicine, Los Angeles, CA, United States.
authors.forename: Brian
authors.initials: B
authors.lastname: Wu
authors.affiliation: School of Human Performance and Recreation, University of Southern Mississippi, Hattiesburg, MS, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Credeur
authors.affiliation: School of Sport and Exercise, University of Gloucestershire, United Kingdom.
authors.forename: Simon
authors.initials: S
authors.lastname: Fryer
authors.affiliation: School of Sport and Exercise, Massey University, New Zealand. Electronic address: L.stoner@massey.ac.nz.
authors.forename: Lee
authors.initials: L
authors.lastname: Stoner
mesh_terms: D015415:Biomarkers; D001696:Biomechanical Phenomena; D001916:Brachial Artery / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000502:physiology; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D012039:Regional Blood Flow; D033081:Shear Strength; D014664:Vasodilation
chemical_list: D015415:Biomarkers