title: Expedient access to α,β-difunctionalized azepenes using α-halo eneformamides: application to the one-pot synthesis of 2-benzazepanes.
abstract: The regioselective synthesis of α,β-difunctionalized (alkenyl, aryl, sulfonyl, allyl, or alkynyl) azepenes has been accomplished through α-halo eneformamides. A successful implementation of the vicinal functionalization strategy has led to a one-pot synthesis of 2-benzazepanes whose benzenoid portion is highly functionalized.
authors.affiliation: Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA. beng@susqu.edu.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Bassler
authors.forename: Laura
authors.initials: L
authors.lastname: Spence
authors.forename: Amir
authors.initials: A
authors.lastname: Alwali
authors.forename: Oliver
authors.initials: O
authors.lastname: Beale
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Beng
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D005559:Formamides / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001552:Benzazepines; D005559:Formamides; D006846:Hydrocarbons, Halogenated