title: Sol-gel encapsulation of biomolecules and cells for medicinal applications.
abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
authors.forename: Nada Ben
authors.initials: NB
authors.lastname: Ahmed
authors.forename: Gisela S
authors.initials: GS
authors.lastname: Alvarez
authors.forename: Maria V
authors.initials: MV
authors.lastname: Tuttolomondo
authors.forename: Christophe
authors.initials: C
authors.lastname: Hélary
authors.forename: Martin F
authors.initials: MF
authors.lastname: Desimone
authors.affiliation: Chimie de la Matiere Condensee, College de France, 11 place Marcelin Berthelot, 75005 Paris, France. thibaud.coradin@upmc.fr.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Coradin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D018914:Cells, Immobilized; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D005782:Gels; D006801:Humans; D055767:Immobilized Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D044367:Phase Transition; D012822:Silicon Dioxide / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D055767:Immobilized Proteins; D012822:Silicon Dioxide