title: Novel NF-κB inhibitors: a patent review (2011 - 2014).
abstract: BACKGROUND
  The NF-κB family of transcription factors has a vital role in coordinating the expression of a wide variety of genes that control immune responses. The dysfunction of NF-κB has been associated with diseases ranging from inflammation to cancer.
  
  
  METHODS
  In this review, authors provided information on the role of NF-κB in human health and on recently developed inhibitors from patents granted in 2011 - 2014. The reader will gain an understanding of the mechanisms of NF-κB function as well as the structures and biological activities of recently developed NF-κB inhibitors.
  
  
  CONCLUSIONS
  Constitutive NF-κB activation is likely involved in the pathogenesis of several diseases. Researchers need to consider the specific mechanism of each invented NF-κB inhibitor, as well as the properties of the cellular, in vitro and in vivo assays and targeted diseases. For new drug development, they need various biological tests to assess the potential side effects and optimization of the biological activity.
authors.affiliation: Chungbuk National University, College of Pharmacy , Cheongju 362-763 , Republic of Korea +82 43 261 2811 ; medchem@chungbuk.ac.kr.
authors.forename: Sateesh Kumar
authors.initials: SK
authors.lastname: Arepalli
authors.forename: Minho
authors.initials: M
authors.lastname: Choi
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Jung
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
mesh_terms: D000818:Animals; D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010330:Patents as Topic
chemical_list: D016328:NF-kappa B
keywords: NF-κB inhibitors; anti-inflammation; antitumor effects; immune responses