title: Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption.
abstract: Even though activation of immunity is associated with bone destruction, new mechanisms have been described in 2014 through which immunology-associated pathways can cooperate to support osteogenesis. These advances support the view of the immune system as a central mechanism which can regulate bone homeostasis, regeneration and destruction.
authors.affiliation: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000276:immunology; D001862:Bone Resorption / Q000276:immunology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000276:immunology; D010012:Osteogenesis / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology