title: Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing?
abstract: Duodenal lymphocytosis is a nonspecific finding that is being detected with heightened frequency. Although increased intraepithelial lymphocytosis with normal villous architecture classically corresponds to grade 1 of the Marsh classification, many other conditions have been reported to be associated with this histologic pattern. In this article, we offer a broad review of the associations of isolated increased intraepithelial lymphocytosis with celiac and nonceliac gluten sensitivity, as well as of the broadening nonceliac etiologies.
authors.affiliation: Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Gregory Y
authors.initials: GY
authors.lastname: Lauwers
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, USA.
authors.forename: Alessio
authors.initials: A
authors.lastname: Fasano
authors.affiliation: Envoi Pathology, Brisbane, Queensland, Australia.
authors.forename: Ian S
authors.initials: IS
authors.lastname: Brown
mesh_terms: D004378:Duodenal Diseases / Q000473:pathology*; D004386:Duodenum / Q000276:immunology / Q000473:pathology; D006801:Humans; D008218:Lymphocytosis / Q000473:pathology*