title: Protein synthesis regulation, a pillar of strength for innate immunity?
abstract: Recognition of pathogen derived molecules by Pattern Recognition Receptors (PRR) induces the production of cytokines (i.e. type I interferons) that stimulate the surrounding cells to transcribe and translate hundreds of genes, in order to prevent further infection and organize the immune response. Here, we report on the rising matter that metabolism sensing and gene expression control at the level of mRNA translation, allow swift responses that mobilize host defenses and coordinate innate responses to infection.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France; INSERM, U1104, 13288 Marseille, France; CNRS, UMR 7280, 13288 Marseille, France.
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Argüello
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France; INSERM, U1104, 13288 Marseille, France; CNRS, UMR 7280, 13288 Marseille, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Rodriguez Rodrigues
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France; INSERM, U1104, 13288 Marseille, France; CNRS, UMR 7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: gatti@ciml.univ-mrs.fr.
authors.forename: Evelina
authors.initials: E
authors.lastname: Gatti
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France; INSERM, U1104, 13288 Marseille, France; CNRS, UMR 7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: pierre@ciml.univ-mrs.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pierre
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition; D058570:TOR Serine-Threonine Kinases