title: [The suppression of a herpes simplex virus reproduction with drug resistance by combination 15lys-bis-nt and phosphate of acycloguanosine with some antiherpetic drugs].
abstract: Antiherpetic activity of the double and triple combinations, including original connections 15Lys-bis-Nt and phosphate of acycloguanosine (P-ACG), was studied in vitro. For the first time, it was demonstrated that in case of their combined use with known antiherpetic agents, whose activity does not depend on TK of HSV (PFA, AraA, CDV, Rib, GLN, αa-IFN), synergistic or additive effects of interaction was observed. The antiviral effect of the tested combinations was studied on the model of ACG-resistant viral strain. The tested combinations could be of interest for practical medicine.
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: S L
authors.initials: SL
authors.lastname: Grokhovskiĭ
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: G V
authors.initials: GV
authors.lastname: Gurskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Surovaia
authors.forename: M V
authors.initials: MV
authors.lastname: Jas'ko
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Skoblov
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral / Q000187:drug effects / Q000235:genetics; D004357:Drug Synergism; D006561:Herpes Simplex / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir