title: Metabolic regulation of histone post-translational modifications.
abstract: Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as cosubstrates or act as activators/inhibitors. Therefore, metabolism can influence histone modification by changing local concentrations of key metabolites. Physiologically, the epigenetic response to metabolism is important for nutrient sensing and environment adaption. In pathologic states, the connection between metabolism and histone modification mediates epigenetic abnormality in complex disease. In this review, we summarize recent studies of the molecular mechanisms involved in metabolic regulation of histone modifications and discuss their biological significance.
authors.affiliation: Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin-Madison , Madison, Wisconsin 53715, United States.
authors.forename: Jing
authors.initials: J
authors.lastname: Fan
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Krautkramer
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Feldman
authors.forename: John M
authors.initials: JM
authors.lastname: Denu
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000107:Acetylation; D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D000105:Acetyl Coenzyme A; D006655:Histone Deacetylases