title: Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever.
abstract: OBJECTIVE
  Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis.
  
  
  METHODS
  A total of 60 patients with FMF and 60 healthy age- and sex-matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated.
  
  
  RESULTS
  We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation.
  
  
  CONCLUSIONS
  Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large-scale prospective studies on this issue are needed.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: drakifacay@gmail.com.
authors.forename: Akif
authors.initials: A
authors.lastname: Acay
authors.affiliation: Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Memnune Sena
authors.initials: MS
authors.lastname: Ulu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ahsen
authors.affiliation: Department of Cardiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Ozkececi
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Kasim
authors.initials: K
authors.lastname: Demir
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Ozuguz
authors.affiliation: Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Seref
authors.initials: S
authors.lastname: Yuksel
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Gursel
authors.initials: G
authors.lastname: Acarturk
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood*; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D000071198:Pyrin; D014280:Triglycerides / Q000097:blood*; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D014280:Triglycerides
keywords: Atherogenic index; Atherosclerosis; Familial Mediterranean fever; Inflammation