title: Comparison of cerebral blood flow data obtained by computed tomography (CT) perfusion with that obtained by xenon CT using 320-row CT.
abstract: Cerebral blood flow (CBF) data obtained by computed tomography perfusion (CTP) imaging have been shown to be qualitative data rather than quantitative, in contrast with data obtained by other imaging methods, such as xenon CT (XeCT) imaging. Thus, interpatient comparisons of CBF values themselves obtained by CTP may be inaccurate. In this study, we have compared CBF ratios as well as CBF values obtained from CTP-CBF data to those obtained from XeCT-CBF data for the same patients to determine CTP-CBF parameters that can be used for interpatient comparisons. The data used in the present study were obtained as volume data using 320-row CT. The volume data were applied to an automated region of interest-determining software (3DSRT, version 3.5.2 ) and converted to 59 slices of 2 mm interval standardized images. In the present study, we reviewed 10 patients with occlusive cerebrovascular diseases (CVDs) undergoing both CTP and XeCT in the same period. Our study shows that ratios of CBF measurements, such as hemodynamic stress distribution (perforator-to-cortical flow ratio of middle cerebral artery [MCA] region) or the left/right ratio for the region of the MCA, calculated using CTP data have been shown to correlate well with the same ratios calculated using XeCT data. These results suggest that such CBF ratios could be useful for generating interpatient comparisons of CTP-CBF data obtained by 320-row CT among patients with occlusive CVD.
authors.affiliation: Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan; Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan. Electronic address: satoshi710@mac.com.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tanizaki
authors.affiliation: Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Akaji
authors.affiliation: Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Tadashige
authors.initials: T
authors.lastname: Kano
authors.affiliation: Department of Neurology, Nippon Medical School, Tokyo, Japan; Department of Stroke Medicine, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Neurology, Nippon Medical School, Tokyo, Japan; Department of Stroke Medicine, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Takayama
authors.affiliation: Department of Stroke Medicine, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kanzawa
authors.affiliation: Department of Neurosurgery, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Satoka
authors.initials: S
authors.lastname: Shidoh
authors.affiliation: Department of Image Diagnosis, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakazawa
authors.affiliation: Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Ban
authors.initials: B
authors.lastname: Mihara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D061330:Multidetector Computed Tomography; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D012039:Regional Blood Flow; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014978:Xenon
chemical_list: D003287:Contrast Media; D014978:Xenon
keywords: CT perfusion; Cerebral blood flow; automated ROI; hemodynamic stress distribution; xenon CT