title: Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus.
abstract: Six sesquiterpenoids 1-6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A-D 3-6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).
authors.affiliation: Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. chunjung@usc.edu.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Gao
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA. chunjung@usc.edu.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Guo
authors.affiliation: Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. zerkang@126.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. zhouwenming2008@nwsuaf.edu.cn.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Zhou
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA. clayw@usc.edu.
authors.forename: Clay C C
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. jinminggao@nwsuaf.edu.cn.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D016466:CHO Cells; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012717:Sesquiterpenes; C000601871:asperaculane A; C000601872:asperaculane B