title: Correlations of ezrin expression with pathological characteristics and prognosis of osteosarcoma: a meta-analysis.
abstract: We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966-2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945-2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.
authors.affiliation: 3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
authors.forename: Da-Hang
authors.initials: DH
authors.lastname: Zhao
authors.affiliation: 3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: 3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Wang
authors.affiliation: 4th Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Hong-Wu
authors.initials: HW
authors.lastname: Fan
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Jing-Zhe
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Wang
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016239:MEDLINE; D008297:Male; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D012516:Osteosarcoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins; D000099149:Ezrin