title: Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana.
abstract: Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
authors.affiliation: a Department of Chemistry , Higher Teacher Training College, University of Yaoundé 1 , P.O. Box 47, Yaoundé , Cameroon.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Ndongo
authors.forename: Mark E
authors.initials: ME
authors.lastname: Issa
authors.forename: Angelique N
authors.initials: AN
authors.lastname: Messi
authors.forename: Joséphine Ngo
authors.initials: JN
authors.lastname: Mbing
authors.forename: Muriel
authors.initials: M
authors.lastname: Cuendet
authors.forename: Dieudonné E
authors.initials: DE
authors.lastname: Pegnyemb
authors.forename: Christian G
authors.initials: CG
authors.lastname: Bochet
mesh_terms: D044946:Biflavonoids / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D043842:Ochnaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D044946:Biflavonoids; D005419:Flavonoids; D010936:Plant Extracts; C079168:agathisflavone; C011164:amentoflavone
keywords: Ochna schweinfurthiana; Ochnaceae; cytotoxic activity; flavonoids