title: A clinical study on the efficacy of Panchavalkala cream in Vrana Shodhana w.s.r to its action on microbial load and wound infection.
abstract: BACKGROUND
  The science of wound healing is advancing rapidly, particularly as a result of new therapeutic approaches. The wound healing effect of different herbal ointments have been enormous and are in wide practice these days.
  
  
  OBJECTIVE
  To evaluate the efficacy of Panchavalkala cream over wound debridement (wound infection and microbial load).
  
  
  METHODS
  Ghanasatwa (water extract) of the individual drugs of Panchavalkala was prepared and the extract formulated as herbal ointment. This was used to treat patients of infected chronic non healing wounds. The signs and symptoms of infection were graded before and during the course of treatment. Tissue biopsy to estimate the microbial load prior to and during the course of treatment was done.
  
  
  RESULTS
  The clinical symptoms like Slough, swelling, redness, pain, discharge, tenderness, and malodor in wounds showed statistically significant reduction following treatment. The microbial load of the wounds was also reduced significantly.
  
  
  CONCLUSIONS
  In most of the cases, there was a progressive reduction in the microbial load with time, during the course of treatment indicating the efficacy of the formulation in reducing the microbial load and thus controlling infection, facilitating wound healing.
authors.affiliation: Department of Agadatantra, S. D. M. College of Ayurveda, Kuthpady, Udupi, India.
authors.forename: K Shobha
authors.initials: KS
authors.lastname: Bhat
authors.affiliation: Department of Prasootitantra and Striroga, S. D. M. College of Ayurveda, Hassan, Karnataka, India.
authors.forename: B N
authors.initials: BN
authors.lastname: Vishwesh
authors.affiliation: Department of Shalyatantra, Faculty of Ayurveda, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Sahu
authors.affiliation: Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Shukla
keywords: Chronic non healing wounds; Panchavalkala; Vrana Shodhana; infection; microbial load