title: Regulation of the Renin-Angiotensin System Pathways in the Human Decidua.
abstract: Pregnancy outcome is influenced, in part, by the sex of the fetus. Decidual renin messenger RNA (REN) abundance is greater in women carrying a female fetus than a male fetus. Here, we explore whether the sex of the fetus also influences the regulation of decidual RAS expression with a known stimulator of renal renin and cyclic adenosine monophosphate (cAMP). Cyclic adenosine monophosphate had no affect on decidual REN expression, since REN abundance was still greater in decidual explants from women carrying a female fetus than a male fetus after cAMP treatment. Cyclic adenosine monophosphate decreased prorenin levels in the supernatant if the fetus was female (ie, prorenin levels were no longer sexually dimorphic) and altered the fetal sex-specific differences in other RAS genes seen in vitro. Therefore, fetal sex influences the decidual renin-angiotensin system response to cAMP. This may be related to the presence of fetal cells in the maternal decidua.
authors.affiliation: School of Biomedical Sciences & Pharmacy, Mothers & Babies Research Centre, University of Newcastle, Hunter Medical Research Institute & John Hunter Hospital, Newcastle, Australia.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Biomedical Sciences & Pharmacy, Mothers & Babies Research Centre, University of Newcastle, Hunter Medical Research Institute & John Hunter Hospital, Newcastle, Australia.
authors.forename: Eugenie R
authors.initials: ER
authors.lastname: Lumbers
authors.affiliation: School of Biomedical Sciences & Pharmacy, Mothers & Babies Research Centre, University of Newcastle, Hunter Medical Research Institute & John Hunter Hospital, Newcastle, Australia.
authors.forename: Shane D
authors.initials: SD
authors.lastname: Sykes
authors.affiliation: School of Biomedical Sciences & Pharmacy, Mothers & Babies Research Centre, University of Newcastle, Hunter Medical Research Institute & John Hunter Hospital, Newcastle, Australia kirsty.pringle@newcastle.edu.au.
authors.forename: Kirsty G
authors.initials: KG
authors.lastname: Pringle
mesh_terms: D003656:Decidua / Q000502:physiology*; D005321:Extraembryonic Membranes / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009924:Organ Culture Techniques; D011247:Pregnancy; D012084:Renin-Angiotensin System / Q000502:physiology*; D012727:Sex Characteristics; D015398:Signal Transduction / Q000502:physiology*
keywords: cAMP; decidua; fetal sex; renin; renin–angiotensin system