title: A novel 4-aminoantipyrine-Pd(II) complex catalyzes Suzuki-Miyaura cross-coupling reactions of aryl halides.
abstract: A simple and efficient catalytic system based on a Pd complex of 4-aminoantipyrine, 4-AAP-Pd(II), was found to be highly active for Suzuki-Miyaura cross-coupling of aryl iodides and bromides with phenylboronic acids under mild reaction conditions. Good to excellent product yields from the cross-coupling reaction can be achieved when the reaction is carried out in ethanol, in the open air, using low loading of 4-AAP-Pd(II) as a precatalyst, and in the presence of aqueous K2CO3 as the base. A variety of functional groups are tolerated.
authors.affiliation: Laboratorio de Síntesis y Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, México. CP 58030, tel.: +52 443 326 5790; fax: +52 443 326 5788.
authors.forename: Claudia Araceli
authors.initials: CA
authors.lastname: Contreras-Celedón
authors.affiliation: Laboratorio de Síntesis y Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, México. CP 58030, tel.: +52 443 326 5790; fax: +52 443 326 5788.
authors.forename: Darío
authors.initials: D
authors.lastname: Mendoza-Rayo
authors.affiliation: Laboratorio de Síntesis y Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, México. CP 58030, tel.: +52 443 326 5790; fax: +52 443 326 5788.
authors.forename: José A
authors.initials: JA
authors.lastname: Rincón-Medina
authors.affiliation: Laboratorio de Síntesis y Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, México. CP 58030, tel.: +52 443 326 5790; fax: +52 443 326 5788.
authors.forename: Luis
authors.initials: L
authors.lastname: Chacón-García
keywords: 4-aminoantipyrine; arylboronic acids; biaryls; cross-coupling; palladium(II) complex