title: Associations between the Expression of micro-RNA 214 and clinicopathologic parameters of glioma.
abstract: It have been reported that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation. However, the specific role of miR-214 in glioma remains unknown. Thus, we investigated the relationship between expression level of miR-214 and clinico- pathological features and prognosis in patients with glioma in a follow-up of 5years. We used Chi-square tests for the categorical data and Mann-Whitney tests for continuous data. Survival time was calculated from the date of glioma diagnosis to the date of death or last follow-up. Survival analysis was estimated using the Kaplan-Meier method, log-rank test, and Cox-proportional hazards regression model. In the present study, we confirmed that the expression level of miR-214 was increased in glioma tissues compared with the non-neoplastic brain tissues. Next, the Kaplan-Meier analysis revealed that glioma patients with high miR-214 expression tend to have poorer overall survival. In addition, the multivariate analysis clearly demonstrated that high miR-214 expression was a statistically significant risk factor affecting overall survival in glioma patients, suggesting that miR-214 upregulation in gliomas is not only in a grade-dependent fashion, it is also a predictor of overall survival. Finally, subgroup analyses showed the significant prognostic value of miR-214 upregulation for glioma patients in those with low and high pathological grade. The results of this study showed that miR-214 was up-regulated in glioma tissues. The expression of miR-214 was associated with the pathological stages of glioma. The results of 5-years follow-up showed that the expression level of miR-214 is a significant prognostic factor for patients with glioma.
  
  
  BACKGROUND
  miR-214, glioma, prognosis.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Yan
authors.forename: F
authors.initials: F
authors.lastname: Tian
authors.forename: Y
authors.initials: Y
authors.lastname: Su
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: C
authors.initials: C
authors.lastname: Dou