title: Using registries to recruit subjects for clinical trials.
abstract: OBJECTIVE
  We studied the use of patient/disease registries to recruit potential subjects for prospective clinical trials - describing the number, types and major benefits of using this approach.
  
  
  METHODS
  In December 2013, we conducted a focused database search in PubMed, EMBASE, and Web of Science for studies (English language only) that used registries to recruit subjects for clinical trials published in 2004-2013. Of the 233 unique citations identified, 21 used registries to recruit subjects - 10 papers and 11 abstracts. Pearling and search for subsequent full papers of the abstracts identified 4 more papers.
  
  
  RESULTS
  Our analysis, based on these 25 citations, showed that 14 are related to cancer, 3 to diabetes mellitus, 1 each to stroke, asthma, and celiac disease and 5 are disease neutral. Many types of registries (population-based cancer, quality improvement, disease-specific, web-based disease-neutral registries, local general practice registers, and national health database) are used to recruit subjects for clinical trials and uncover new knowledge. Overall, 16 registries are in the US, 4 in UK, 1 each in Canada, Spain, and Australia and 1 involved in many countries. Registries can identify very large number of subjects for screening for eligibility for clinical trials, especially in very large trials, rare disease trials, and trials involving minority patients.
  
  
  CONCLUSIONS
  Registries can retrospectively identify very large numbers of potential subjects for screening for eligibility and enrollment in prospective clinical trials. This matching can lead to more timely recruitment and help solve a major problem in conducting clinical trials.
authors.affiliation: Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA. Electronic address: mengt@med.umich.edu.
authors.forename: Meng H
authors.initials: MH
authors.lastname: Tan
authors.affiliation: College of Human Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Taubman Health Sciences Library, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Mark P
authors.initials: MP
authors.lastname: MacEachern
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D018579:Patient Selection; D012042:Registries
keywords: Clinical trials; Patient registries; Recruitment of subjects