title: High performance liquid chromatography characteristic spectrum of artificial musk.
abstract: OBJECTIVE
  To determine the high performance liquid chromatography(HPLC)characteristic spectrum of artificial musk.
  
  
  METHODS
  HPLC was performed on a HiQ Sil C18 analytical column(4.6 mm×250 mm)with the mobile phase of methanol/water(90:10 v/v);the detection wavelength was 254 nm and the column temperature was maintained at 25 ℃. The similarities among 10 batches of artificial musk samples were anlysised in accordance with the System for Evaluating the Similarities among the Chromatographic Fingerprints of Traditional Chinese Drugs,which is recommended by Chinese Pharmacopoeia Commission.
  
  
  RESULTS
  The similarities among these 10 batches of artificial musk ranged between 0.999 and 1.000.
  
  
  CONCLUSIONS
  HPLC is a convenient,accurate and reliable technique for establishing the specific spectum of artificial musk and therefore can be used for the quality control of this product.
authors.affiliation: Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China.
authors.forename: Nan-Ping
authors.initials: NP
authors.lastname: Zhang
authors.affiliation: Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China.
authors.forename: Xin-Yue
authors.initials: XY
authors.lastname: Xiao
authors.affiliation: Department of Technology,Beijing Lianxin Pharmaceutic Co.,Ltd,Beijing 102628,China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D011786:Quality Control
chemical_list: D004365:Drugs, Chinese Herbal; D005229:Fatty Acids, Monounsaturated; C008563:musk