title: Paradoxical response to intravenous immunoglobulin in a case of Parvovirus B19-associated chronic fatigue syndrome.
abstract: We describe a case of chronic fatigue syndrome (CFS) associated to Parvovirus B19 infection where administration of intravenous immunoglobulins (IVIG), previously reported as effective, induced a paradoxical clinical response and increased viral replication. The indication of IVIG administration in the treatment of Parvovirus B19-associated CFS should be carefully reconsidered.
authors.affiliation: University of Bologna, Department of Medicine and Surgery, Division of Infectious Diseases, S.Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Attard
authors.affiliation: University of Bologna, Department of Pharmacy and Biotechnology, S.Orsola-Malpighi Hospital - Microbiology, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bonvicini
authors.affiliation: University of Bologna, Department of Diagnostic, Experimental and Specialty Medicine, S.Orsola-Malpighi Hospital - Microbiology, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Gelsomino
authors.affiliation: University of Bologna, Department of Medicine and Surgery, Division of Infectious Diseases, S.Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredi
authors.affiliation: University of Bologna, Department of Medicine and Surgery, Division of Infectious Diseases, S.Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cascavilla
authors.affiliation: University of Bologna, Department of Medicine and Surgery, Division of Infectious Diseases, S.Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
authors.affiliation: University of Bologna, Department of Diagnostic, Experimental and Specialty Medicine, S.Orsola-Malpighi Hospital - Microbiology, Bologna, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Varani
authors.affiliation: University of Bologna, Department of Pharmacy and Biotechnology, S.Orsola-Malpighi Hospital - Microbiology, Bologna, Italy. Electronic address: giorgio.gallinella@unibo.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gallinella
mesh_terms: D000328:Adult; D000914:Antibodies, Viral; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D004279:DNA, Viral; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D018655:Lymphocyte Count; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D016732:Parvovirus B19, Human / Q000145:classification* / Q000235:genetics; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D016756:Immunoglobulins, Intravenous
keywords: Chronic fatigue syndrome; Intravenous immunoglobulin therapy; Parvovirus B19