title: Neutrophil-rich gastric carcinoma in the integrated cancer registry of eastern Sicily, Italy.
abstract: OBJECTIVE
  Neutrophil-rich carcinoma is a variant of gastric carcinoma that has not been well-studied or characterized. The purpose of the present study was to reveal the incidence and clinicopathological findings compared to ordinary gastric carcinoma.
  
  
  METHODS
  A population-based series of 430 gastric cancers, identified between 2003 and 2006 from the province of Messina (insular Italy; population, 662,450), was used. The number of tumor-infiltrating neutrophils was assessed in a semi-quantitative manner using the mean value of 20 non-overlapping high-power fields (magnification, 400; 0.08 mm(2)). Tumors with >10 neutrophils per 20 high-power fields were arbitrarily considered as neutrophil-rich gastric carcinomas. Moreover, MUC1 immunohistochemical expression was investigated to show possible correlation with neutrophil infiltration in gastric carcinomas.
  
  
  RESULTS
  Among 193 gastric cancers resected for curative purposes, 30 (15.54%) were represented by neutrophil-rich gastric carcinomas. These tumors occurred more frequently in patients aged more than 72 years (p<0.05), showing an inverse correlation with mucinous subtype according to the WHO classification (p<0.001) and expressed MUC1. However, intensity and distribution of MUC1 was heterogeneous, and independent of neutrophil infiltration within the tumor stroma.
  
  
  CONCLUSIONS
  Neutrophil-rich carcinoma seems to represent a distinctive morphological variant of gastric carcinoma, although the true mechanism for the infiltration of neutrophils is still unclear.
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Branca
authors.affiliation: della Salute (SASTAS), Università di Messina, Messina, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Parisi
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Irato
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Venuti
authors.affiliation: Dipartimenti di Patologia Umana e di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e, Università di Messina, Messina, Italy rosariocaruso@tin.it.
authors.forename: Rosario A
authors.initials: RA
authors.lastname: Caruso
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000276:immunology* / Q000378:metabolism; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D020556:Neutrophil Infiltration; D012802:Sicily / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000276:immunology* / Q000378:metabolism
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1
keywords: Cancer Registry Study; Gastric adenocarcinoma; Messina province; tumor-infiltrating neutrophils