title: Hydrolysis of Letrozole catalyzed by macrocyclic Rhodium (I) Schiff-base complexes.
abstract: Ten mononuclear Rhodium (I) complexes were synthesized by macrocyclic ligands having N4 and N2O2 donor sites. Square planar geometry is assigned based on the analytical and spectral properties for all complexes. Rh(I) complexes were investigated as catalysts in hydrolysis of Nitrile group containing pharmaceutical drug Letrozole. A comparative study showed that all the complexes are efficient in the catalysis. The percent yields of all the catalytic reaction products viz. drug impurities were determined by spectrophotometric procedures and characterized by spectral studies.
authors.affiliation: Department of Chemistry, Nizam College, Osmania University, Hyderabad, India.
authors.forename: P Muralidhar
authors.initials: PM
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India.
authors.forename: K
authors.initials: K
authors.lastname: Shanker
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India.
authors.forename: V
authors.initials: V
authors.lastname: Srinivas
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India.
authors.forename: E Ravi
authors.initials: ER
authors.lastname: Krishna
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India; Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan.
authors.forename: R
authors.initials: R
authors.lastname: Rohini
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India.
authors.forename: G
authors.initials: G
authors.lastname: Srikanth
authors.affiliation: Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan. Electronic address: anren@mail.tcu.edu.tw.
authors.forename: Anren
authors.initials: A
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, Telangana, India. Electronic address: ravichemku@rediffmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Ravinder
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002384:Catalysis; D004553:Electric Conductivity; D004583:Electrons; D006868:Hydrolysis; D000077289:Letrozole; D047028:Macrocyclic Compounds / Q000737:chemistry*; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D009570:Nitriles / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012238:Rhodium / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000737:chemistry*
chemical_list: D047028:Macrocyclic Compounds; D009570:Nitriles; D012545:Schiff Bases; D014230:Triazoles; D000077289:Letrozole; D012238:Rhodium
keywords: Hydrolysis; Letrozole; Rhodium (I) complexes; Spectral studies; Spectrophotometry