title: Serum pentosidine levels after 3 years of bisphosphonate treatment in post-menopausal osteoporotic women.
abstract: The present study measured changes in plasma pentosidine and bone turnover markers in elderly patients with osteoporosis treated using bisphosphonate. The relationship between pentosidine and bone turnover markers and bone mineral density (BMD) was investigated. This study consisted of post-menopausal osteoporotic women who could be treated using bisphosphonate for 3 years were included in the present analysis. The study population consisted of 58 cases, all women, ranging in age from 53 to 86 years (mean, 67.1 years). Bisphosphonate treatment significantly increased BMD of the lumbar spine to 0.914 ± 0.141 g/cm(2) and BMD of the femoral neck to 0.708 ± 0.086 g/cm(2) after 3 years (p < 0.001 versus baseline). The mean BAP level was 27.3 ± 8.3 U/L in patients at baseline. After bisphosphonate treatment, BAP significantly decreased to 18.1 ± 7.2 U/L at 3 years (p < 0.001). Urinary NTX also decreased after bisphosphonate treatment. After 3 years of treatment, urinary NTX significantly decreased from 50.0 ± 19.0 nmol BCE/mmol Cr to 24.6 ± 10.2 nmol BCE/mmol Cr at 3 years (p < 0.001). Serum pentosidine levels were 0.0413 ± 0.0094 μg/mL at baseline and 0.0413 ± 0.0122 μg/mL after 3 years. They were not significantly changed by bisphosphonate treatment. Serum pentosidine levels were not changed by treatment with bisphosphonates. Thus, serum pentosidine may not be suitable as a marker of bone quality after 3 years of bisphosphonate treatment.
authors.affiliation: Department of Orthopedic Surgery, Shinshu University , Matsumoto , Japan and.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hashidate
authors.forename: Mikio
authors.initials: M
authors.lastname: Kamimura
authors.forename: Shota
authors.initials: S
authors.lastname: Ikegami
authors.forename: Keijiro
authors.initials: K
authors.lastname: Mukaiyama
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects*; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D004164:Diphosphonates; D015675:Osteocalcin; D001120:Arginine; C062187:pentosidine; D008239:Lysine
keywords: Bisphosphonate; bone turnover markers; osteoporosis; serum pentosidine