title: [Development and application of six-channel fiber optic sensing drug dissolution monitor].
abstract: The drug dissolution test is an important examination of drug testing, which plays a very important role in the drug quality assessment. Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology. Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation, with xenon lamp, deuterium lamp or halogen tungsten lamp as fluorescence, UV and visible light source, branch Y type optical fiber as light path transmission medium, UV-Vis probe and fluorescence molecular probe as light response devices, and CCD as detector. Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming, and sampling of off-line analysis, but also provides real-time information of drug dissolution process. Thus, our study may provide a better evaluation method for the drug quality control.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Xin-Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D065546:Drug Liberation; D005336:Fiber Optic Technology; D055100:Optical Fibers; D011786:Quality Control; D012984:Software; D012996:Solutions
chemical_list: D012996:Solutions