title: Linezolid induced black hairy tongue.
abstract: Black hairy tongue (BHT) also called as lingua villosa nigra, is a self limiting benign condition characterized by hypertrophy and elongation of filiform papillae of tongue with brown or black discoloration. Smoking, poor oral hygiene, xerostomia, using peroxide containing mouth washes, substance abuse and drugs (steroids, methyldopa, olanzapine, etc) are the predisposing factors. However its occurrence in relation to linezolid ingestion among south Indians has not been reported in PubMed database. Here we report a case, where significant association of linezolid intake with BHT was found in a 10-year-old boy, who was treated with tablet linezolid for post surgical infection of left side radial neck fracture. This case is reported for the rarity of occurrence with linezolid therapy. According to Naranjo adverse drug reaction (ADR) causality scale, the association of BHT due to linezolid in our case was probable.
authors.affiliation: Department of Dermato-Venereology, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India.
authors.forename: Govindan
authors.initials: G
authors.lastname: Balaji
authors.affiliation: Department of Pharmacology, Annapoorana Medical College and Hospitals, Salem, Tamil Nadu, India.
authors.forename: B
authors.initials: B
authors.lastname: Maharani
authors.affiliation: Department of Dermato-Venereology, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India.
authors.forename: Velappan
authors.initials: V
authors.lastname: Ravichandran
authors.affiliation: Department of Orthopedics, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India.
authors.forename: Thiyagarajan
authors.initials: T
authors.lastname: Parthasarathi
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002648:Child; D006801:Humans; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000009:adverse effects*; D014064:Tongue, Hairy / Q000139:chemically induced*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid
keywords: Black hairy tongue; Naranjo algorithm; linezolid