title: Diversity of rotavirus strain circulated in gwangju, republic of Korea.
abstract: OBJECTIVE
  The introduction of new rotavirus vaccines into the public sphere makes it necessary to maintain constant surveillance and to heighten public awareness of the appearance of new rotavirus strains. We describe the molecular epidemiology of circulating rotavirus strains after vaccine introduction.
  
  
  METHODS
  We collected a total of 1070 stool samples from children with gastroenteritis from January 2013 to June 2013. The antigenic prevalence of rotavirus group A was distinguished using enzyme immunoassay. The G and P genotypes of enzyme immunoassay-positive samples were determined with reverse transcription-polymerase chain reaction and nucleotide sequencing analysis.
  
  
  RESULTS
  Of the 1070 samples collected, 277 (25.9%) tested positive for rotaviruses by enzyme-linked immunoabsorbent assay. The most prevalent circulating genotype G was G1 (51.3%), followed by G2 (34.7%) and G9 (10.8%). The predominant type of genotype P was P[8] (66.1%), followed by P[4] (31.4%). In this study, nine genotypes were found. G1P[8] was the most prevalent (51.8%), followed by G2P[4] (30.5%), G9P[8] (9.9%), and G2P[8] (4.0%). Several unusual combinations (G1P[4], G3P[9], G3P[8], G4P[6], and G9P[4]) were also identified.
  
  
  CONCLUSIONS
  Molecular epidemiological knowledge of rotaviruses is critical for the development of effective preventive measures, including vaccines. These data will help us monitor the effectiveness of current rotavirus vaccines.
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Division of Vaccine Research, Korea National Institute of Health, Cheongju, Korea.
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Seon Gyeong
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Se Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Kee
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Jo
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Dong-Ryong
authors.initials: DR
authors.lastname: Ha
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Kim
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Kye-Won
authors.initials: KW
authors.lastname: Seo
authors.affiliation: Microbiology Division, Health and Environment Research Institute of Gwangju, Gwangju, Korea.
authors.forename: Jae Keun
authors.initials: JK
authors.lastname: Chung
keywords: genotype G; genotype P; rotavirus; rotavirus vaccine