title: Chronic Opisthorchis viverrini infection and associated hepatobiliary disease is associated with iron loaded M2-like macrophages.
abstract: Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: Moses T
authors.initials: MT
authors.lastname: Bility
authors.affiliation: Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Banchob
authors.initials: B
authors.lastname: Sripa
mesh_terms: D000818:Animals; D006224:Cricetinae; D020869:Gene Expression Profiling; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000469:parasitology* / Q000473:pathology*; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008647:Mesocricetus; D009889:Opisthorchiasis / Q000150:complications* / Q000473:pathology*; D009891:Opisthorchis / Q000302:isolation & purification*
chemical_list: D007501:Iron
keywords: M2-like macrophage; Opisthorchis viverrini; cancer; hepatobiliary fibrosis; iron