title: Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study.
abstract: Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.
authors.affiliation: Department of Pharmacology, Toxicology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
authors.forename: Hayder M
authors.initials: HM
authors.lastname: Alkuraishy
authors.affiliation: Department of Pharmacology, Toxicology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
authors.forename: Ali I
authors.initials: AI
authors.lastname: Al-Gareeb
authors.affiliation: Department of Pharmacology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
authors.forename: Ali K
authors.initials: AK
authors.lastname: Albuhadilly
mesh_terms: D000368:Aged; D001798:Blood Proteins / Q000096:biosynthesis; D001809:Blood Viscosity / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004357:Drug Synergism; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011746:Pyrithioxin / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D012212:Rheology; D014748:Vinca Alkaloids / Q000008:administration & dosage*
chemical_list: D001798:Blood Proteins; D014748:Vinca Alkaloids; C013983:vinpocetine; D011746:Pyrithioxin