title: Acute stress and working memory in older people.
abstract: Several studies have shown that acute stress affects working memory (WM) in young adults, but the effect in older people is understudied. As observed in other types of memory, older people may be less sensitive to acute effects of stress on WM. We performed two independent studies with healthy older men and women (from 55 to 77 years old) to investigate the effects of acute stress (Trier Social Stress Test; TSST) and cortisol on WM. In study 1 (n = 63), after the TSST women (but not men) improved their performance on Digit Span Forward (a measure of the memory span component of WM) but not on Digit Span Backward (a measure of both memory span and the executive component of WM). Furthermore, in women, cortisol levels at the moment of memory testing showed a positive association with the memory span component of WM before and after the TSST, and with the executive component of WM only before the stress task. In study 2 (n = 76), although participants showed a cortisol and salivary alpha-amylase (sAA) response to the TSST, stress did not affect performance on Letter-Number Sequencing (LNS; a task that places a high demand on the executive component of WM). Cortisol and sAA were not associated with WM. The results indicate that circulating cortisol levels at the moment of memory testing, and not the stress response, affect memory span in older women, and that stress and the increase in cortisol levels after stress do not affect the executive component of WM in older men and women. This study provides further evidence that older people may be less sensitive to stress and stress-induced cortisol response effects on memory processes.
authors.affiliation: Department of Psychobiology and IDOCAL, Laboratory of Social Cognitive Neuroscience, University of Valencia , Valencia , Spain.
authors.forename: Matias M
authors.initials: MM
authors.lastname: Pulopulos
authors.forename: Vanesa
authors.initials: V
authors.lastname: Hidalgo
authors.forename: Mercedes
authors.initials: M
authors.lastname: Almela
authors.forename: Sara
authors.initials: S
authors.lastname: Puig-Perez
authors.forename: Carolina
authors.initials: C
authors.lastname: Villada
authors.forename: Alicia
authors.initials: A
authors.lastname: Salvador
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry; D055291:Salivary alpha-Amylases / Q000378:metabolism; D012919:Social Behavior; D013315:Stress, Psychological / Q000378:metabolism / Q000523:psychology*
chemical_list: D055291:Salivary alpha-Amylases; D006854:Hydrocortisone
keywords: Aging; cortisol; hypothalamus–pituitary–adrenal axis; older people; stress; working memory