title: [Simplification of antiretroviral therapy: proposal for a score for the evaluation of patients with suppressed viremia].
abstract: Simplification of a suppressive triple antiretroviral therapy to a dual or monotherapy has demonstrated safety and efficacy in a high proportion of stable patients. The key rationales behind regimen simplification are to improve the patient's quality of life and to maintain long-term compliance, without enhancing the risk of virological failure. A simplified startegy offers the potential advantages of a decreased risk of toxicities associated with the use of nucleoside analogue reverse transcriptase inhibitors. Moreover, the use of high genetic barrier antiretroviral drugs (basically, PIs/r) in dual regimen or in monotherapy regimen minimises the selection of drug-resistant HIV variants. The aim of this paper is to present a score that taking into account all the data in the literature relating to the simplification studies to monotherapy with PI/r allows the clinician to have more information to choose with less chance of error by the patient simplify.
authors.forename: Massimo
authors.initials: M
authors.lastname: Andreoni
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D055118:Medication Adherence; D011788:Quality of Life; D014766:Viremia / Q000188:drug therapy*
chemical_list: D019380:Anti-HIV Agents