title: [Treatment of lymphoblastic leukemia with CD19-specific modified chimeric antigen receptor T cells].
abstract: Bioengineered T cells, which are the genetically manipulated T cells to express chimeric antigen receptor T Cell (CAR T) against leukemia-associated specific antigens, were applied to treat acute and chronic lymphocytic leukemia with CAR T. CAR T cells combined with cell-surface binding site and anti-CD19 chimeric antigen receptor can treat diseases through T cells transfection. CAR T cells can recognize the CD19 antigen on B cells with specific cell-surface loci. CAR T cells can proliferate by 1000 times and differentiate in vivo by the CD19 antigen stimulation, therefore, kill the acute and chronic lymphocytic leukemia cells effectively. This article briefly reviews the CAR T cells and the effect of CAR T cells on acute and chronic lymphoblastic leukemia.
authors.affiliation: Hematology & Oncology Institute,Beijing Aerospace General Hospital, Beijing 100076, China; Department of Pediatrics, The Fist Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Hematology, Peking University Fist Hospital, Beijing 100034, China. E-mail: zhupingbj@gmail.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: 1Hematology & Oncology Institute,Beijing Aerospace General Hospital, Beijing 100076, China.
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Wu
authors.affiliation: Department of Pediatrics, The Fist Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000818:Animals; D018941:Antigens, CD19; D001402:B-Lymphocytes; D006801:Humans; D016219:Immunotherapy, Adoptive; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes
chemical_list: D018941:Antigens, CD19; D011948:Receptors, Antigen, T-Cell