title: Antibiotics in frozen bone grafts can cause allergic reactions in recipient patients.
abstract: Antibiotic prophylaxis is a routine procedure during total hip arthroplasty (THA), and the vast majority of cadavers within the multitissue procurement receive one or more antibiotics. Upon harvesting, bone grafts are stored in the bone banks on the temperature as low as -80°C for up to 5 years. It is shown in the literature that the antibiotics remain active and viable in the bone grafts even after being exposed to extremely low temperatures in the prolonged periods. Possibility of remnant antibiotic concentrations in the bone grafts and the fact that these antibiotic remnants maintain active even after being exposed to extremely low temperatures create the environment in which the possibility for the allergic reaction in sensitive patient receiving bone graft exists. We hypothesize that harvested bone grafts containing active antibiotic substance have the potential for local and systemic allergic reaction in sensitive recipient patients thus increasing morbidity and the costs of the treatment. Allergic reactions can mimic surgical site infections as well with the consequent substantial pitfalls in the treatment. Following that, in the setting of an assumed but not confirmed surgical site infection, the immunological evaluation on antibiotics for recipients of bone grafts could be added to the standard diagnostic algorithms. In addition, bone banks should be obliged to provide information of all potential drugs that can be found in every specific bone graft to the end users.
authors.affiliation: University Hospital Centre Zagreb, Department of Orthopaedic Surgery, Zagreb, Croatia.
authors.forename: Kresimir
authors.initials: K
authors.lastname: Crnogaca
authors.affiliation: University of Zagreb School of Medicine, University Hospital Centre Zagreb, Department of Orthopaedic Surgery, Zagreb, Croatia. Electronic address: gbic@mef.hr.
authors.forename: Goran
authors.initials: G
authors.lastname: Bicanic
authors.affiliation: University of Zagreb School of Medicine, University Hospital Centre Zagreb, Department of Orthopaedic Surgery, Zagreb, Croatia.
authors.forename: Domagoj
authors.initials: D
authors.lastname: Delimar
mesh_terms: D064591:Allografts / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000032:analysis; D016025:Bone Transplantation / Q000009:adverse effects*; D001842:Bone and Bones / Q000737:chemistry*; D015925:Cryopreservation; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D014015:Tissue Banks / Q000592:standards; D066027:Transplant Recipients
chemical_list: D000900:Anti-Bacterial Agents