title: Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients.
abstract: The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.
authors.affiliation: Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University , Dayton, OH , USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Coyne
authors.affiliation: Department of Obstetrics and Gynecology, University of Kentucky College of Medicine , Lexington, KY , USA.
authors.forename: MacKenzie
authors.initials: M
authors.lastname: Purdy
authors.affiliation: Wright-Patterson USAF Medical Center , Dayton, OH , USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: O'Leary
authors.affiliation: Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University , Dayton, OH , USA.
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Yaklic
authors.affiliation: Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University , Dayton, OH , USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Lindheim
authors.affiliation: Department of Obstetrics and Gynecology, University of Kentucky College of Medicine , Lexington, KY , USA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Appiah
keywords: assisted reproduction; controlled ovarian stimulation; follicular phase; luteal phase; oncofertility