title: [Disseminated mucormycosis in immunocompetent patients: A disease that also exists].
abstract: Mucormycosis is usually an acute angioinvasive infections, which leads to non-suppurative necrosis and significant tissue damage. It represents 1.6% of all the invasive fungal infections and predominates in immunosuppressed patients with risk factors. Incidence has been significantly increased even in immunocompetent patients. Due to finding a case of disseminated mucormycosis caused by Rhizomucor pusillus in a young immunocompetent patient, a systematic review was carried out of reported cases in PubMed of mucormycosis in immunocompetent adults according to the main anatomic locations, and especially in disseminated cases. A review of the main risk factors and pathogenicity, clinical manifestations, techniques of early diagnosis, current treatment options, and prognosis is presented. Taxonomy and classification of the genus Mucor has also been reviewed.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Reina Sofía, Córdoba, España; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, España; Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Córdoba, España. Electronic address: juancarlos.pozo@ono.com.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Pozo Laderas
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pontes Moreno
authors.affiliation: Servicio Urología, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pozo Salido
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Robles Arista
authors.affiliation: Servicio de Microbiología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: María José
authors.initials: MJ
authors.lastname: Linares Sicilia
mesh_terms: D000382:Agricultural Workers' Diseases / Q000382:microbiology; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003881:Dermatomycoses / Q000382:microbiology / Q000628:therapy; D016469:Fungemia / Q000276:immunology*; D005658:Fungi / Q000145:classification; D006801:Humans; D007121:Immunocompetence; D015994:Incidence; D009091:Mucormycosis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D009894:Opportunistic Infections / Q000276:immunology / Q000628:therapy; D012141:Respiratory Tract Infections / Q000382:microbiology; D012307:Risk Factors; D012988:Soil Microbiology
chemical_list: D000935:Antifungal Agents
keywords: Anfotericina B liposómica; Disseminated mucormycosis; Immunocompetent; Inmunocompetente; Liposomal amphotericin B; Mucormicosis diseminada; Rhizomucor pusillus