title: Mechanisms of daughter cell-size control during cell division.
abstract: Daughter cell size is tightly regulated during cell division. In animal cells, the position of the anaphase spindle specifies the cell cleavage site to dictate the relative size of the daughter cells. Although spindle orientation is regulated by dynein-dependent cortical pulling forces exerted on astral microtubules in many cell types, it was unclear how these forces are precisely regulated to center or displace the spindle. Recently, intrinsic signals derived from chromosomes or spindle poles have been demonstrated to regulate dynein-dependent pulling forces in symmetrically dividing cells. Unexpectedly, myosin-dependent contractile forces have also been shown to control spindle position by altering the cellular boundaries during anaphase. In this review, I discuss how dynein- and myosin-dependent forces are coordinately regulated to control daughter cell size.
authors.affiliation: Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan; Precursory Research for Embryonic Science and Technology (PRESTO) Program, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. Electronic address: kiyomitsu@bio.nagoya-u.ac.jp.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kiyomitsu
mesh_terms: D000705:Anaphase / Q000502:physiology; D000818:Animals; D002455:Cell Division / Q000502:physiology*; D048429:Cell Size; D002875:Chromosomes / Q000378:metabolism; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D009218:Myosins; D004398:Dyneins
keywords: Ran-GTP; daughter cell size; dynein; myosin; spindle positioning