title: Clinicopathological findings and five year survival rates for patients with central nervous system tumors in Yazd, Iran.
abstract: BACKGROUND
  The incidence rate of brain tumors has increased more than 40% in the past 20 years, especially in adults. We aimed to study the clinical and pathological findings of central nervous system (CNS) tumor patients and to evaluate their 5 year survival rates.
  
  
  METHODS
  The archives of all patients with CNS tumors in 6 health care centers in Yazd, Iran, from 2006 to 2013, were studied. Patients data were extracted using a checklist which included age, sex, date of reference and diagnosis, date of death, clinical signs, radiography findings, pathology report, size and location of tumor, patient treatment and grade of tumor.
  
  
  RESULTS
  A total of 306 patient records were studied in the 8 year period. The most prevalent type of tumor was astrocytoma (n=113, 36.9%). The frequency of almost all tumor types was statistically higher in male patients (p=0.025). In most cases surgery with radiotherapy was the treatment of choice (49.3%). The most frequent symptom reported was headache (in 60.8% of patients) followed by convulsions (15.7%). Most of the tumors were located in the right hemisphere (46.1%) and the frontal and parietal lobe (26% and 12%, respectively). Radiography findings displayed edema with a nonhomogeneous lesion in majority of the patients (87%). The survival fraction of the patients with malignant tumors decreased over time (0.807 in the first year and 0.358 at the end of the 5th year).
  
  
  CONCLUSIONS
  Astrocytoma was the more common CNS tumor with male predominance. Overall survival rates of malignant tumors decreased over time and this was in relation with tumor grade.
authors.affiliation: Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran E-mail : taghipour@ssu.ac.ir.
authors.forename: Shokouh Taghipour
authors.initials: ST
authors.lastname: Zahir
authors.forename: Mahmood
authors.initials: M
authors.lastname: Vakili
authors.forename: Hossein
authors.initials: H
authors.lastname: Navabii
authors.forename: Koorosh
authors.initials: K
authors.lastname: Rahmani
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006261:Headache / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008297:Male; D008579:Meningioma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009837:Oligodendroglioma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011859:Radiography; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D017678:Sex Distribution; D015996:Survival Rate; D055815:Young Adult