title: [Treatment of endometrial carcinoma].
abstract: The mainstay of the initial treatment for endometrial carcinoma is surgery with total hysterectomy and bilateral salpingo-oophorectomy. Pelvic-aortic lymphadenectomy may be appropriate for patients having tumors with a high risk for extrauterine spread. Most importantly, these include carcinomas with deep (≥ 50%) myometrial invasion, poor differentiation, or nonendometrioid histology, in which lymphadenectomy aids in prognostication and tailoring of adjuvant treatments. Vaginal cuff brachytherapy ensures vaginal control in stage I endometrioid carcinomas with high-risk features. For advanced carcinomas, chemotherapy is the adjuvant treatment of choice, combined with whole pelvic external beam radiotherapy in selected cases.
authors.affiliation: HYKS.
authors.forename: Mikko
authors.initials: M
authors.lastname: Loukovaara
authors.forename: Anna
authors.initials: A
authors.lastname: Luomaranta
authors.forename: Arto
authors.initials: A
authors.lastname: Leminen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010052:Ovariectomy; D058994:Salpingectomy
chemical_list: D000970:Antineoplastic Agents