title: Successful lysis of bilateral renal vein thrombosis following neonatal truncus repair.
abstract: Renal vein thrombosis (RVT) is the most common noncatheter-related thrombosis encountered in infancy, most of which occurs in neonates. The optimal management strategy for neonatal RVT is unclear. Fibrinolytic and heparin therapy may play a role in preventing chronic renal failure in neonates with bilateral RVT. However, the use of fibrinolytics early after any major surgery requires tremendous caution. In this report, we describe the successful use of fibrinolysis in a neonate with bilateral RVT after repair of truncus arteriosus in the early postoperative period.
authors.affiliation: Queensland Pediatric Cardiac Services, Mater Children's Hospital, South Brisbane, Australia Department of Surgery, University of Queensland, Brisbane, Australia.
authors.forename: Sudesh
authors.initials: S
authors.lastname: Prabhu
authors.affiliation: Queensland Pediatric Cardiac Services, Mater Children's Hospital, South Brisbane, Australia Department of Surgery, University of Queensland, Brisbane, Australia.
authors.forename: Karthik
authors.initials: K
authors.lastname: Ramakrishnan
authors.affiliation: Queensland Pediatric Cardiac Services, Mater Children's Hospital, South Brisbane, Australia Department of Surgery, University of Queensland, Brisbane, Australia nelsonalphonso@mac.com.
authors.forename: Nelson
authors.initials: N
authors.lastname: Alphonso
authors.affiliation: Pediatric Intensive Care, Mater Children's Hospital, South Brisbane, Australia.
authors.forename: Kevin
authors.initials: K
authors.lastname: McCaffery
authors.affiliation: Queensland Pediatric Cardiac Services, Mater Children's Hospital, South Brisbane, Australia Department of Medicine, University of Queensland, Brisbane, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Anderson
authors.affiliation: Queensland Pediatric Cardiac Services, Mater Children's Hospital, South Brisbane, Australia Department of Surgery, University of Queensland, Brisbane, Australia.
authors.forename: Tom
authors.initials: T
authors.lastname: Karl
mesh_terms: D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D011183:Postoperative Complications / Q000188:drug therapy*; D012082:Renal Veins; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014339:Truncus Arteriosus, Persistent / Q000601:surgery*; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator
keywords: cardiac surgical procedure; complications; fibrinolysis; newborn; truncus arteriosus; venous thrombosis