title: DNA damage responses: beyond double-strand break repair.
abstract: The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.
authors.affiliation: Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO 63110-1093, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Bredemeyer
authors.affiliation: Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO 63110-1093, USA. Electronic address: Sleckman@wustl.edu.
authors.forename: Barry P
authors.initials: BP
authors.lastname: Sleckman
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins