title: Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Infertility associated with polycystic ovary syndrome (PCOS) could be related to many mechanisms including endometrial factors.
  
  
  OBJECTIVE
  To review cell adhesion molecule and estrogen receptor expression in the endometrium.
  
  
  METHODS
  A systematic review was performed of the Medline and Cochrane databases for papers published in any language between 2004 and 2014. The search term was "'polycystic ovary syndrome' OR 'Stein Leventhal syndrome' OR 'anovulation' AND 'endometrium' OR 'endometria.'"
  
  
  METHODS
  Research studies on endometrial cell adhesion molecules and estrogen receptor expression among women with PCOS diagnosed according to the Rotterdam criteria were included.
  
  
  METHODS
  Data were extracted from identified studies and the quality of assessment was analyzed.
  
  
  RESULTS
  Six studies were included. Data were controversial with respect to MUC1 and αVβ3 integrin expression with significantly higher and lower levels, respectively, in women with PCOS. Estrogen receptor expression was enhanced among patients with PCOS as compared with healthy women.
  
  
  CONCLUSIONS
  Endometrial factors influence embryo receptivity as indicated by the molecular mediators identified in the studies, including cell adhesion molecules and the estrogen receptor.
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Maria Cândida P
authors.initials: MC
authors.lastname: Baracat
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Serafini
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Ricardo Dos S
authors.initials: Rdos S
authors.lastname: Simões
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Gustavo A R
authors.initials: GA
authors.lastname: Maciel
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: jsoares415@hotmail.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Soares
authors.affiliation: Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D011960:Receptors, Estrogen
keywords: Endometrium; Molecular aspects; Polycystic ovary syndrome; Systematic review