title: Total synthesis of (-)-dolastatrienol.
abstract: The first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target.
authors.affiliation: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road.
authors.forename: Lai To
authors.initials: LT
authors.lastname: Leung
authors.forename: Pauline
authors.initials: P
authors.lastname: Chiu
keywords: carbenes; cascade reaction; natural products; rhodium; total synthesis