title: Extrahepatic biliary atresia in a 4-week-old Pug.
abstract: OBJECTIVE
  To report diagnosis and surgical therapy of extrahepatic biliary atresia in a dog.
  
  
  METHODS
  Clinical report.
  
  
  METHODS
  Dog (n = 1).
  
  
  METHODS
  A 4-week-old female intact Pug presented with acholic feces, lethargy, and poor weight gain. On the basis of the stool color and abdominal ultrasonography findings, extrahepatic biliary atresia was suspected. Intraoperatively, no major duodenal papilla was identified and cholecystoduodenostomy was performed.
  
  
  RESULTS
  One day postoperatively the stool color was considered normal. On ultrasonographic examinations up to 6 months after surgery, the gall bladder remained small and the stoma was functional. Serum biochemical profile after 10 months had a mild increase in alanine-aminotransferase (149 U/L; reference interval [RI], 0-85 U/L) whereas alkaline phosphatase and glutamate dehydrogenase were within normal limits. At 15 months, clinical examination was normal and blood ammonia concentration was within normal limits (43 µmol/L; RI: <100 µmol/L) but bile acid concentrations were still markedly elevated (fasting, 95 µmol/L [RI: <20 µmol/L] to postprandial, 127 µmol/L [RI: <35 µmol/L]).
  
  
  CONCLUSIONS
  Ultrasonography and stool color can be helpful noninvasive diagnostic evidence in extrahepatic biliary atresia. Surgical correction with cholecystoduodenostomy with a good clinical outcome is possible even in very young dogs. Long-term prognosis in dogs with extrahepatic biliary atresia is unknown.
authors.affiliation: Department of Veterinary Clinical Sciences, Clinic for Small Animals, Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
authors.forename: Cetina
authors.initials: C
authors.lastname: Thiel
authors.forename: Sarah
authors.initials: S
authors.lastname: Steinbach
authors.forename: Martin
authors.initials: M
authors.lastname: Schmidt
authors.forename: Kerstin
authors.initials: K
authors.lastname: Amort
authors.forename: Nanette
authors.initials: N
authors.lastname: Zahn
authors.forename: Martin
authors.initials: M
authors.lastname: Kramer
authors.forename: Andreas
authors.initials: A
authors.lastname: Moritz
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017734:Bile Ducts, Extrahepatic / Q000002:abnormalities*; D001656:Biliary Atresia / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D004285:Dogs; D005260:Female; D011379:Prognosis; D014463:Ultrasonography