title: Fractionate effect of ionizing radiation and nitric oxide on tumor growth in rats.
abstract: Objective. To investigate the effect of ionizing radiation and nitrogen oxides on the growth and development of Guerin's carcinoma transplanted in rats. Materials and methods. Studies have been conducted on white nonlinear male rats weighing 125-160 g. Animals were exposed of nitrogen oxides and/or ionizing radiation, and then were transplanted Guerin's carcinoma. The dynamics of tumor growth and changes of free radical processes in the blood system by biophysical and biochemical methods were investigated. Results. It is shown that the effect of the studied environmental factors leads to disruption of oxidative processes in the animal's organism, which contributes to the growth and development of tumors. Conclusion. Pre-exposure to low doses of ionizing radiation and/or exogenous nitrogen oxides significantly accelerates the growth of Guerin's carcinoma. This process is accompanied by a disturbance of oxidative metabolism and the development of oxidative stress.
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: O B
authors.initials: OB
authors.lastname: Ganzha
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: M O
authors.initials: MO
authors.lastname: Druzhyna
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: L I
authors.initials: LI
authors.lastname: Makovetska
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: O O
authors.initials: OO
authors.lastname: Glavin
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: L F
authors.initials: LF
authors.lastname: Klepets
authors.affiliation: R.E. Kavetskyy Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasilkovskaya str., Kyiv, 03022, Ukraine.
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhailenko
keywords: Guerin's carcinoma; free radical processes; ionizing radiation; nitrogen oxides; the blood system