title: No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials.
abstract: Proton pump inhibitors are increasingly being used to treat infants with crying and/or irritability based on the assumption that these symptoms are attributable to gastroesophageal reflux. However, the data from a systematic review of randomized controlled trials do not support the use of proton pump inhibitors to decrease infant crying and irritability.
authors.affiliation: Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Gieruszczak-Białek
authors.affiliation: Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Konarska
authors.affiliation: Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Skórka
authors.affiliation: Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Vandenplas
authors.affiliation: Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland. Electronic address: hania@ipgate.pl.
authors.forename: Hania
authors.initials: H
authors.lastname: Szajewska
mesh_terms: D003448:Crying / Q000523:psychology*; D004644:Emotions / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007223:Infant; D007508:Irritable Mood / Q000187:drug effects*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D054328:Proton Pump Inhibitors