title: An update on inflammation in the acute phase of intracerebral hemorrhage.
abstract: Intracerebral hemorrhage (ICH) is a common and severe neurological disorder, which is associated with high rates of mortality and morbidity. Despite extensive research into the pathology of ICH, there are still no clinically approved neuroprotective treatments. Currently, increasing evidence has shown that inflammatory responses participate in the pathophysiological processes of brain injury following ICH. In this editorial, we summarized some promising advances in the field of inflammation and ICH, which contained animal and human investigations; discussed the role of neuroinflammation, systemic inflammatory responses, and some potential targets; and focused on the challenges of translation between pre-clinical and clinical studies and potential anti-inflammatory therapeutic approaches after ICH.
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: John H
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D004660:Encephalitis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans
chemical_list: D000893:Anti-Inflammatory Agents