title: Parabrachial lesions in rats disrupt sodium appetite induced by furosemide but not by calcium deprivation.
abstract: An appetite for CaCl2 and NaCl occurs in young rats after they are fed a diet lacking Ca or Na, respectively. Bilateral lesions of the parabrachial nuclei (PBN) disrupt normal taste aversion learning and essentially eliminate the expression of sodium appetite. Here we tested whether similar lesions of the PBN would disrupt the calcium-deprivation-induced appetite for CaCl2 or NaCl. Controls and rats with PBN lesions failed to exhibit a calcium-deprivation-induced appetite for CaCl2. Nevertheless, both groups did exhibit a significant calcium-deprivation-induced appetite for 0.5M NaCl. Thus, while damage to the second central gustatory relay in the PBN disrupts the appetite for 0.5M NaCl induced by furosemide, deoxycorticosterone acetate, and polyethylene glycol, the sodium appetite induced by dietary CaCl2 depletion remains intact.
authors.affiliation: Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: psg6@psu.edu.
authors.forename: P S
authors.initials: PS
authors.lastname: Grigson
authors.affiliation: Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: emc231@psu.edu.
authors.forename: E M
authors.initials: EM
authors.lastname: Colechio
authors.affiliation: Nutrition Laboratory and Conservation Ecology Center, Smithsonian Conservation Biology Institute, National Zoological Park, P. O. Box 37012, MRC 5503, Washington, DC 20013-7012, USA. Electronic address: mpower@acog.org.
authors.forename: M L
authors.initials: ML
authors.lastname: Power
authors.affiliation: Department of Neuroscience, Basic Sciences Building, Georgetown University, 3900 Reservoir Road, N.W., Washington, DC 20057, USA. Electronic address: Jschulkin@acog.org.
authors.forename: J
authors.initials: J
authors.lastname: Schulkin
authors.affiliation: Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: rxn5@psu.edu.
authors.forename: R
authors.initials: R
authors.lastname: Norgren
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D002118:Calcium / Q000172:deficiency*; D002122:Calcium Chloride / Q000008:administration & dosage; D003213:Conditioning, Psychological / Q000187:drug effects; D064791:Desoxycorticosterone Acetate / Q000494:pharmacology; D004195:Disease Models, Animal; D004232:Diuretics / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005665:Furosemide / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000633:toxicity; D065823:Parabrachial Nucleus / Q000293:injuries* / Q000502:physiology; D011092:Polyethylene Glycols; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D004232:Diuretics; D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D064791:Desoxycorticosterone Acetate; D005665:Furosemide; D002122:Calcium Chloride; D002118:Calcium
keywords: Calcium depletion; Mineral appetite; Parabrachial; Sodium depletion