title: Accessorizing and anchoring the LINC complex for multifunctionality.
abstract: The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements. Recent studies have shed light on the source of this diversity by identifying factors associated with the complex that endow specific functions as well as those that differentially anchor the complex within the nucleus. Additional diversity may be provided by accessory factors that reorganize the complex into higher-ordered arrays. As core components of the LINC complex are associated with several diseases, understanding the role of accessory and anchoring proteins could provide insights into pathogenic mechanisms.
authors.affiliation: Department of Pathology and Cell Biology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
authors.forename: Wakam
authors.initials: W
authors.lastname: Chang
authors.affiliation: Department of Pathology and Cell Biology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 Department of Pathology and Cell Biology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Worman
authors.affiliation: Department of Pathology and Cell Biology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 ggg1@columbia.edu.
authors.forename: Gregg G
authors.initials: GG
authors.lastname: Gundersen
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D040542:Mechanotransduction, Cellular; D046912:Multiprotein Complexes / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs; D021381:Protein Transport; D013314:Stress, Mechanical
chemical_list: D046912:Multiprotein Complexes