title: Recent progress in dengue vaccine development.
abstract: Dengue virus (DENV) has four distinct serotypes. DENV infection can result in classic dengue fever and life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent decades, DENV infection has become an important public health concern in epidemic-prone areas. Vaccination is the most effective measure to prevent and control viral infections. However, several challenges impede the development of effective DENV vaccines, such as the lack of suitable animal models and the antibody-dependent enhancement phenomenon. Although no licensed DENV vaccine is available, significant progress has been made. This review summarizes candidate DENV vaccines from recent investigations.
authors.affiliation: Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: An
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology / Q000821:virology*; D053059:Dengue Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D003716:Dengue Virus / Q000235:genetics / Q000276:immunology*; D006801:Humans
chemical_list: D053059:Dengue Vaccines