title: Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population.
abstract: A missense C/T polymorphism in exon 6 (the NCBI rsID is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer's disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with sporadic Alzheimer's disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and TT genotype distribution frequencies had significant differences between sporadic Alzheimer's disease patients and healthy controls. In-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer's disease indicated that people with the C-positive genotype CC + CT were at a higher risk for developing sporadic Alzheimer's disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadic Alzheimer's disease in the Han Chinese population.
authors.affiliation: Department of Neurology, Inner Mongolia People's Hospital, Huhhot 010017, Inner Mongolia Autonomous Region, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
authors.affiliation: Inner Mongolia Corps Hospital, Chinese People's Armed Police Forces, Huhhot 010040, Inner Mongolia Autonomous Region, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qi
keywords: Alzheimer's disease; Han Chinese population; genetic testing; neural regeneration; polymorphism; urokinase plasminogen activator