title: [Clinical efficacy of idarubicin combined with methotrexate for treatment of patients with central nervous system diffuse large B cell lymphoma].
abstract: This study was aimed to investigate the clinical efficacy of idarubicin combined with methotrexate for treatment of patients with central nervous system diffuse large B-cell lymphoma. A total of 88 patients with central nervous system diffuse large B-cell lymphoma was selected, out of them 54 patients received idarubicin combined with methotrexate and were selected as A group, other 34 patients received only methotrexate and were selected as B group (control group). Clinical efficacy and safety were compared after treatment. The results showed that in A group 84 patients achieved complete remission (CR), 5 patients archived partial remission (PR), the total remission rate of A group was 72.2%; in B group 10 patients achieved complete remission (CR), 4 patients archived partial remission (PR), the total remission rate of B group was 41.2%; the average survival time of A group was 33.172 months, and the average survival time of B group was 26.305 months, the former was significantly higher than latter (P < 0.05). It is concluded that idarubicin combined with methotrexate for the patients with central nervous system diffuse large B-cell lymphoma is effective and safe, and may be used in clinic.
authors.affiliation: Department of Interventional Radiology, Jianhu County People's Hospital, Jianhu 224700, Jiangsu Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Department of Hematology, Zhongda Hospital Affiliated to Southeast University Nanjing, Nanjing 210000, Jiangsu Province, China.
authors.forename: Zheng-Ping
authors.initials: ZP
authors.lastname: Yu
authors.affiliation: Department of Interventional Radiology, Jianhu County People's Hospital, Jianhu 224700, Jiangsu Province, China.
authors.forename: Tian-Hua
authors.initials: TH
authors.lastname: Yue
authors.affiliation: Department of Interventional Radiology, Jianhu County People's Hospital, Jianhu 224700, Jiangsu Province, China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Xiao
authors.affiliation: Department of Hematology, Zhongda Hospital Affiliated to Southeast University Nanjing, Nanjing 210000, Jiangsu Province, China. E-mail: cba8888@hotmail.com; bachen@seu.edu.cn.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D008727:Methotrexate; D015255:Idarubicin