title: Asymmetric Michael addition of α-fluoro-α-nitro esters to nitroolefins: towards synthesis of α-fluoro-α-substituted amino acids.
abstract: α-Fluoro-α-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, α-fluoro-α-amino ester with a quaternary α-carbon was prepared for the first time.
authors.affiliation: Graduate School for Integrative Sciences & Engineering (NGS), Centre for Life Sciences (CeLS), National University of Singapore, #05-01, 28 Medical Drive, 117456 Singapore. chmlyx@nus.edu.sg.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kwiatkowski
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D004952:Esters; D008958:Models, Molecular; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000596:Amino Acids; D004952:Esters; D009574:Nitro Compounds