title: Changes of serum neurohormone after renal sympathetic denervation in dogs with pacing-induced heart failure.
abstract: BACKGROUND
  Neurohormonal activation is a commonly cited array of phenomena in the body's physiologic response to heart failure (HF). The aim of the present study was to determine the change law of serum neurohormones after renal sympathetic denervation (RSD) in dogs with pacing-induced HF.
  
  
  METHODS
  Twenty-eight beagles were randomly divided into control group, RSD group, HF group and HF + RSD group. The control group was implanted pacemakers without pacing; the RSD group underwent renal artery ablation without pacing; the HF group was implanted pacemakers with ventricular pacing at 240 bpm for 3 weeks; and HF + RSD group underwent renal artery ablation and with ventricular pacing at 240 bpm for 3 weeks. Blood samples were taken at baseline, and 3, 6, 9, 12, 15, 18, 21 days in all the dogs for neurohormones measurement.
  
  
  RESULTS
  After 3 weeks, the systolic femoral artery pressures in the HF and HF + RSD groups were reduced after pacing 3 weeks. There was an increase significantly in BNP, angiotensin II, aldosterone, endothelin-1 and decrease in renalase after 3 weeks when compared with baseline in HF group. RSD significantly suppressed the changes of plasma neurohormones concentration in experimental HF, but RSD had not obviously impact on the levels of plasma neurohormones during 3 weeks in RSD group.
  
  
  CONCLUSIONS
  RSD attenuates the changes of levels of plasma neurohormones in the activated renin-angiotensin-aldosterone system (RAAS) but had not obviously effect in the normal physiology of RAAS.
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Xule
authors.initials: X
authors.lastname: Wang
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Xiaozhan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Peixing
authors.initials: P
authors.lastname: Wan
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Zongwen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Shengbo
authors.initials: S
authors.lastname: Yu
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University 238 Jiefang Road, Wuhan City 430060, P. R. of China.
authors.forename: Congxin
authors.initials: C
authors.lastname: Huang
keywords: Renal sympathetic nerve; ablation; heart failure; neurohormone