title: Whole mitochondrial genome sequence for an osteoarthritis model of Guinea pig (Caviidae; Cavia).
abstract: Animal models played an important role in osteoarthritis studies. Here, the complete mitochondrial genome sequence of the Guinea pig was reported for the first time. The total length of the mitogenome was 16,797 bp. It contained the typical structure, including two ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes and one non-coding control region (D-loop region). The overall composition of the mitogenome was estimated to be 34.9% for A, 26.1% for T, 26.0% for C and 13.0% for G showing an A-T (61.0%)-rich feature. This mitochondrial genome sequence will provide new genetic resource into osteoarthritis disease.
authors.affiliation: a Department of Spine , Provincial Hospital Affiliated to Shandong University , Jinan , China.
authors.forename: Xin-Gang
authors.initials: XG
authors.lastname: Cui
authors.affiliation: b Department of Orthopedics , The People's Hospital of Zhangqiu , Jinan , China , and.
authors.forename: Cheng-Yao
authors.initials: CY
authors.lastname: Liu
authors.affiliation: c Department of Orthopedics , General Hospital of Yanzhou Coal Mining company , Zoucheng , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
authors.affiliation: c Department of Orthopedics , General Hospital of Yanzhou Coal Mining company , Zoucheng , China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zhao
authors.affiliation: c Department of Orthopedics , General Hospital of Yanzhou Coal Mining company , Zoucheng , China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001482:Base Composition; D018387:Codon, Initiator; D018388:Codon, Terminator; D004195:Disease Models, Animal; D054629:Genome, Mitochondrial; D006168:Guinea Pigs; D016366:Open Reading Frames / Q000235:genetics; D010003:Osteoarthritis / Q000235:genetics* / Q000473:pathology; D012335:RNA, Ribosomal / Q000235:genetics; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics
chemical_list: D018387:Codon, Initiator; D018388:Codon, Terminator; D012335:RNA, Ribosomal; D012343:RNA, Transfer
keywords: Guinea pig; mitochondrial genome; osteoarthritis