title: [Clinical value of N-terminal pro-B-type natriuretic peptide measurement in the follow up of pulmonary vein ablation].
abstract: OBJECTIVE
  N-terminal pro-B-type natriuretic peptide (NT-proBNP) correlates with burden of arrhythmia in atrial fibrillation (AF) patients. Our objective is to validate the usefulness of the measurement of NT-pro-BNP to determine the success of AF ablation in a long term follow up.
  
  
  METHODS
  Prospective observational study in which 75 patients with preserved systolic function (81% men; mean age (SD) 52 (9) years; 58.7% paroxysmal) underwent circumferential pulmonary vein isolation. Determination of NT-proBNP baseline and one year after the procedure was performed. The relation between NT-proBNP levels and the success of the procedure is analyzed.
  
  
  RESULTS
  In the follow up 53 (70.7%) patients remained free of recurrences. A>30% decrease of NT-proBNP levels identified success with a sensitivity of 79.2%, specificity 81.8%, positive predictive value 91.3% and negative 62% (area under ROC curve 0.84, 95% confidence interval 73-95.6). This reduction was associated with a decrease in left atrial volume and pressure and the presence of diastolic dysfunction (all P<.05).
  
  
  CONCLUSIONS
  The decrease of NT-proBNP levels in patients undergoing AF ablation is useful as a marker of success in the follow up and is associated with hemodynamic improvement.
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: eduaru@hotmail.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arana-Rueda
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Alonso
authors.initials: A
authors.lastname: Pedrote
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Lorena
authors.initials: L
authors.lastname: García-Riesco
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Arce-León
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Guerrero-Márquez
authors.affiliation: Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Justo
authors.initials: J
authors.lastname: Rodríguez-Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D011667:Pulmonary Veins / Q000601:surgery*; D012008:Recurrence; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Ablación; Ablation; Atrial fibrillation; Fibrilación auricular; Natriuretic peptides; Péptidos natriuréticos