title: Pathological functions of hypoxia in endometriosis.
abstract: Endometriosis is one of the most common gynecological diseases that significantly reduce the life quality of affected women. Research results from the past decade clearly demonstrated that aberrant production of estrogen and cyclooxygenase-2-derived prostaglandin E2 play indispensable roles in the pathogenesis of this disease. However, the etiology of endometriosis remains obscure. Recent evidence reveals a new facet of endometriotic pathogenesis by showing that hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ectopic endometriotic lesions. These new findings shed lights on future investigations of delineating the etiology of endometriosis and designing new therapeutic strategy for endometriosis.
authors.affiliation: Department of Physiology, College of Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan, 2Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101.
authors.forename: Kuei-Yang
authors.initials: KY
authors.lastname: Hsiao
authors.affiliation: Department of Physiology, College of Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan, 2Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101.
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Lin
authors.affiliation: Department of Physiology, College of Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan, 2Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101.
authors.forename: Meng-Hsing
authors.initials: MH
authors.lastname: Wu
authors.affiliation: Department of Physiology, College of Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan, 2Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101.
authors.forename: Shaw-Jenq
authors.initials: SJ
authors.lastname: Tsai
mesh_terms: D051546:Cyclooxygenase 2 / Q000378:metabolism; D004715:Endometriosis / Q000209:etiology* / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D009389:Neovascularization, Pathologic; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D004967:Estrogens; D020738:Leptin; D011453:Prostaglandins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human