title: Systemic AA amyloidosis as a prion-like disorder.
abstract: Amyloidosis is a collective term for a group of disorders that induce functional impairment of organs and occurs through the accumulation of amyloid, or misfolded protein in beta-sheets. AA amyloidosis is a lethal systemic amyloidosis with SAA as the precursor protein, and is observed in various animal species, including humans. AA amyloidosis can be induced artificially by continuously administering inflammatory stimuli in experimental animal models. In this process of experimental induction, the administration of AA amyloids from either the same or different species is known to markedly expedite AA amyloidosis development, and this is also termed transmission of AA amyloidosis. Similarly to prion disease, AA amyloidosis is considered to be transmitted via a "seeding-nucleation" process. In this manuscript, we reviewed the pathology and transmissibility of AA amyloidosis in animals.
authors.affiliation: Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murakami
authors.affiliation: Department of Veterinary Medicine, Gifu University, Gifu, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Inoshima
authors.affiliation: Department of Veterinary Medicine, Gifu University, Gifu, Japan. Electronic address: ishiguna@gifu-u.ac.jp.
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000686:Amyloidosis / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001715:Bird Diseases / Q000378:metabolism* / Q000473:pathology / Q000635:transmission; D001717:Birds; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism* / Q000473:pathology / Q000635:transmission; D004195:Disease Models, Animal; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D000685:Serum Amyloid A Protein
keywords: Amyloid; Prion; Transmission