title: Successful three-year outcome in a patient with allogenous sternal bone graft in the treatment of massive post-sternotomy defects.
abstract: BACKGROUND
  Deep sternal wound infection is a life-threatening complication of longitudinal median sternotomy with extensive loss of sternal bone tissue and adjacent ribs. Wound dehiscence cases with no loss of bone tissue can be resolved via osteosynthesis using titanium plates. Unfortunately, this cannot be used in cases of massive bone tissue loss defects due to insufficient support for fixing the plate material caused by missing bone surface which increasing the risk of osteosynthesis failure. We describe the treatment outcome of sternal dehiscence with massive bone tissue loss defects using an allogenous sternal bone graft.
  
  
  METHODS
  A 62 year old diabetic female was operated for serious sternotomy dehiscence after surgery for aortic valve replacement. There was bone tissue loss and complications. We used allogenous sternal bone graft to close the wound. To monitor the healing of the graft, we performed SPECT/CT examinations of anterior chest wall. We describe the successful healing of the graft with the reduction of defects in osteoblastic activity by 42% 21 months after the graft implantation. The wound was found to be healed on all examinations, The chest wall is stable and the patient reports a good life quality.
  
  
  CONCLUSIONS
  An allogenous bone transplant contains no vital bone marrow cells, which eliminates immuno-genetic graft rejection by the patient. Significant osteoblastic activity was thus registered, especially in places where crushed spongy bone had been applied.
  
  
  CONCLUSIONS
  Transplantation of allogenous bone graft sternum in our experience is the best option for treating extensive post-sternotomy defects.
authors.affiliation: Department of Cardiosurgery, University Hospital Olomouc and Faculty of Medicine, Palacky University Olomouc, I. P. Pavlova 6, Olomouc 775 20, Czech Republic. Electronic address: martin1.kalab@gmail.com.
authors.forename: Martin
authors.initials: M
authors.lastname: Kaláb
authors.affiliation: National Cell and Tissue Centre, Palachovo náměstí 726/2, Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Karkoška
authors.affiliation: Department of Nuclear Medicine, University Hospital Olomouc and Faculty of Medicine, Palacky University Olomouc, I. P. Pavlova 6, Olomouc 775 20, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Kamínek
authors.affiliation: Department of Cardiosurgery, University Hospital Olomouc and Faculty of Medicine, Palacky University Olomouc, I. P. Pavlova 6, Olomouc 775 20, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Šantavý
keywords: Allogenous bone graft; Deep sternal wound infection; Sternal bone tissue; Sternotomy dehiscence