title: Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component.
abstract: Ovarian yolk sac tumors (YSTs) usually occur in the young women and have been rarely documented in perimenopausal and postmenopausal women. The different age distribution supposes their complex nomenclature and histogenesis. We report a case of bilateral ovarian epithelial carcinoma with right ovarian YST component in a postmenopausal woman. The patient was treated by surgery and adjuvant combination chemotherapy of taxol and carboplatin for 6 courses and has been clinically free of tumor for 6 months. The correlation between the YST and the epithelial components always confuse us. Ovarian yolk sac tumors are not a discrete entity and represent a multifaceted group of neoplasms. The conjunction of multi antibodies help in differential diagnoses. In addition to a thorough case description, the literature concerning this entity is reviewed and discussed.
authors.affiliation: Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University.
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University.
authors.forename: Xiaoduan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D017698:Postmenopause
keywords: GPC-3; PAX8; SALL4; Yolk sac tumor; postmenopausal women; the mixed epithelial adenocarcinoma