title: Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris.
abstract: OBJECTIVE
  Despite the amply evidence and guidelines in treating coronary artery disease (CAD) with lipid-lowering therapy, physicians still have concerns in treating acute myocardial infarction (AMI) patients who have the low serum lipid level. We explored the adequacy of lipid-lowering therapy in treating AMI patients.
  
  
  METHODS
  Over 3000 CAD lipid profile data were collected, their data were divided into 3 groups (AMI; stable angina pectoris (SAP) and unstable angina pectoris (UAP) group) based their clinical characteristics. Statistical analyses were performed to compare their baseline lipid levels and clinical feature.
  
  
  RESULTS
  The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) level in AMI patients were the lowest, followed by UAP patient group and SAP patient group. There were significant differences in white blood count (WBC) and ejection fraction (EF) between 3 groups. A good correlation was confirmed between EF% and the lipid parameters of TC, LDL-c, HDL-c, non-HDL-c. WBC did not correlate with the lipid except HDL-c. AMI is an acute inflammatory reaction that is accompanied with the change of lipid level.
  
  
  CONCLUSIONS
  Although the level of TC, LDL-c and HDL-c are lower in AMI, but it is related with acute inflammatory reaction during the rupture of atherosclerotic plaques. Lipid-lowering therapy should not be delayed in treating AMI patients with lower lipid level.
authors.affiliation: Department of Cardiology, and Department of Cardiology Medicine, Tianjin Chest Hospital, Tianjin, China. qinqin6999@163.com.
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.forename: J-P
authors.initials: JP
authors.lastname: Feng
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Kou
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Ren
authors.forename: L-L
authors.initials: LL
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Qin
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood* / Q000175:diagnosis; D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008077:Lipoproteins, LDL; D002784:Cholesterol