title: Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ).
abstract: The medication-related osteonecrosis of the jaw (MRONJ) is believed to be a therapy-resistant entity. Although the application of the recommended conservative and surgical treatment regimens have returned variable success rates, the increased awareness and experience with MRONJ suggests that surgical therapy can halt the progression of the disease, thereby allowing a histology-based diagnosis of the osteonecrosis. Surgical treatment protocols can achieve success rates of over 90% and novel techniques such as the visualization of bone fluorescence can assist in the intra-operative delineation of the osteonecrosis and standardize the procedure.
authors.affiliation: University of Heidelberg, Department of Oral and Maxillofacial Surgery, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; Medizin & Aesthetik, Clinic for Oral and Maxillofacial and Plastic Surgery, Lenbachplatz 2a, D-80333 Munich, Germany. Electronic address: oliver.ristow@med.uni-heidelberg.de.
authors.forename: Oliver
authors.initials: O
authors.lastname: Ristow
authors.affiliation: Ludwig-Maximilians Universität München, Department of Oral and Maxillofacial Surgery, Lindwurmstr. 2a, D-80336 Munich, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Otto
authors.affiliation: Ludwig-Maximilians Universität München, Department of Oral and Maxillofacial Surgery, Lindwurmstr. 2a, D-80336 Munich, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Troeltzsch
authors.affiliation: Medizin & Aesthetik, Clinic for Oral and Maxillofacial and Plastic Surgery, Lenbachplatz 2a, D-80333 Munich, Germany; Technische Universität München, Department of Oral and Maxillofacial Surgery, Ismaninger Str. 22, D-81675 Munich, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hohlweg-Majert
authors.affiliation: Medizin & Aesthetik, Clinic for Oral and Maxillofacial and Plastic Surgery, Lenbachplatz 2a, D-80333 Munich, Germany; Ludwig-Maximilians Universität München, Department of Oral and Maxillofacial Surgery, Lindwurmstr. 2a, D-80336 Munich, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Pautke
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis / Q000601:surgery*; D003646:Debridement / Q000379:methods; D018450:Disease Progression; D005453:Fluorescence; D006801:Humans; D007430:Intraoperative Care; D010027:Osteotomy / Q000379:methods; D016896:Treatment Outcome
keywords: BRONJ; Bisphosphonate; Denosumab; Fluorescence-guided bone resection; Osteonecrosis of the jaw; Surgical treatment