title: Heterogeneous nuclear ribonucleoproteins (hnRNPs) and human transformer-2-beta1 (hTra2-beta1)-regulated estrogen receptor-alpha improves prognosis of endometrial cancer.
abstract: OBJECTIVE
  Heterogeneous nuclear ribonucleoprotein (hnRNP) family possesses decreasing effect towards endometrial cancer (EC) and human transformer-2-betal (hTra2-betal) performs an intimate relationship with EC, either. Recent study shows that hnRNPs and hTra2-betal regulate the genetic expression, which is concerned with estrogen receptor (ER).
  
  
  METHODS
  The present study was designed to investigate the link between ER and hnRNPs or hTra2-betal in the prognosis of EC patients by Real-time PCR and immunohistochemisty (IHC).
  
  
  RESULTS
  Results showed that ER protein expression presented a significant change in the recurrence and outcome of EC patients, and the nucleus hTra2-betal protein expression was also increased in the recurrent patients, indicating that the three might be important in ER expression in the prognosis therapy of EC patients.
  
  
  CONCLUSIONS
  The present findings provide an insight of pharmaceutical targeting therapy and prognosis of EC.
authors.affiliation: Tongji University School of Medicine, Shagnhai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Gao
authors.forename: Yujie
authors.initials: Y
authors.lastname: Sun
authors.forename: Huaifang
authors.initials: H
authors.lastname: Li
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Tong
authors.forename: Yiqin
authors.initials: Y
authors.lastname: Ouyang
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D016601:RNA-Binding Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D060888:Real-Time Polymerase Chain Reaction; D000068103:Serine-Arginine Splicing Factors
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C097083:TRA2B protein, human; D000068103:Serine-Arginine Splicing Factors