title: Rh(III)-catalyzed redox-neutral C-H activation of pyrazolones: an economical approach for the synthesis of N-substituted indoles.
abstract: A new strategy is reported for the economical synthesis of indoles bearing an N-(3-aminobut-2-enoyl) substituent through Rh(III)-catalyzed redox-neutral C-H activation of pyrazolones and alkynes. This approach utilizes cheap substrates and mild reaction conditions to access a unique class of indoles via a N-N bond oxidative cleavage without loss of the N-terminus, therefore meeting all the atom/step/redox economy principles.
authors.affiliation: CAS Key Laboratory of Receptor Research and ‡State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences , Shanghai 201203, China.
authors.forename: Zhoulong
authors.initials: Z
authors.lastname: Fan
authors.forename: Shanshan
authors.initials: S
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Kaijun
authors.initials: K
authors.lastname: Geng
authors.forename: Youjun
authors.initials: Y
authors.lastname: Xu
authors.forename: Ze-Hong
authors.initials: ZH
authors.lastname: Miao
authors.forename: Ao
authors.initials: A
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D006860:Hydrogen Bonding; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D047069:Pyrazolones / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D007211:Indoles; D047069:Pyrazolones; D012238:Rhodium