title: Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo.
abstract: OBJECTIVE
  Vitiligo is an acquired pigmentary skin disease that can cause serious cosmetic problems. There have been numerous and well established studies that have demonstrated the comorbidity of various psychiatric disorders in patients with vitiligo. However, to our knowledge, there have been no studies investigating whether a psychiatric biomarker, such as brain-derived neurotrophic factor (BDNF), is associated with vitiligo.
  
  
  METHODS
  This study was conducted in Namık Kemal University Medical Faculty, Departments of Dermatology and Psychiatry between January 2013 and September 2014. After meeting inclusion and exclusion criteria, serum BDNF levels were assayed in 57 patients with first onset vitiligo and no known current or past psychiatric disorder and compared with BDNF levels in 58 age and sex matched healthy subjects.
  
  
  RESULTS
  The age and female/male ratios were similar between groups. The mean values of serum BDNF were 1.57±0.97 ng/dL and 2.37±1.73 ng/dL in the vitiligo group and in the healthy control group, respectively. The mean BDNF level was significantly higher in the healthy control group compared with the vitiligo group (t=2.76, P=0.007).
  
  
  CONCLUSIONS
  This is the first study to compare serum BDNF levels between patients with vitiligo and healthy subjects. The reduced level of serum BDNF in patients with vitiligo may be directly related to the etiology of vitiligo or associated with the high percentage of psychiatric disorders in that patient population. Further studies are needed to support our preliminary results.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: M Emin
authors.initials: ME
authors.lastname: Yanik
authors.affiliation: Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Erfan
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Albayrak
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.affiliation: Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kulac
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kuloglu
keywords: disease; neurotrophin; psychosomatic; skin