title: Translating the MAM model of psychosis to humans.
abstract: Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and function are two of the most robust findings in schizophrenia, but how interactions between these abnormalities underlie the onset of psychosis is unclear. The methylazoxymethanol acetate (MAM) rodent model proposes that psychosis develops as a result of a perturbation of MTL function, leading to elevated striatal dopamine dysfunction. Here, we review several recent neuroimaging studies that examine components of the putative model in humans with an ultra high risk (UHR) of the psychosis. While data from these studies are broadly consistent with the MAM model, caution is required when comparing data across animal and human studies.
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: gemma.modinos@kcl.ac.uk.
authors.forename: Gemma
authors.initials: G
authors.lastname: Modinos
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Allen
authors.affiliation: Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Grace
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: McGuire
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D008746:Methylazoxymethanol Acetate; D011618:Psychotic Disorders / Q000473:pathology / Q000503:physiopathology*
chemical_list: D008746:Methylazoxymethanol Acetate
keywords: animal research; neurobiology; neuroimaging; prodrome; psychosis; schizophrenia