title: Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes.
abstract: Recent insights into the relationship between the human gut and its resident microbiota have revolutionized our appreciation of this symbiosis and its impact on health and disease development. Accumulating evidence on probiotic and prebiotic interventions has demonstrated promising effects on promoting gastrointestinal health by modulating the microbiota toward the enrichment of beneficial microorganisms. However, the precise mechanisms of how prebiotic nondigestible oligosaccharides are metabolized by these beneficial microbes in vivo remain largely unknown. Genome sequencing of probiotic lactobacilli and bifidobacteria has revealed versatile carbohydrate metabolic gene repertoires dedicated to the catabolism of various oligosaccharides. In this review, we highlight recent findings on the genetic mechanisms involved in the utilization of prebiotic fructooligosaccharides, β-galactooligosaccharides, human milk oligosaccharides, and other prebiotic candidates by these probiotic microbes.
authors.affiliation: Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina 27695; email: yjgoh@ncsu.edu , klaenhammer@ncsu.edu.
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Goh
authors.forename: Todd R
authors.initials: TR
authors.lastname: Klaenhammer
mesh_terms: D001644:Bifidobacterium / Q000378:metabolism*; D007778:Lactobacillus / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism*; D056692:Prebiotics; D019936:Probiotics
chemical_list: D009844:Oligosaccharides; D056692:Prebiotics
keywords: Bifidobacterium; Lactobacillus; fructooligosaccharide; galactooligosaccharide; prebiotic; probiotic