title: IAP gene deletion and conditional knockout models.
abstract: Gene deletion studies have helped reveal the unique and overlapping roles played by IAP proteins. Crossing IAP mutant mice has helped unravel the complex feed-back regulatory circuits in which cIAP1, cIAP2 and XIAP allow innate defensive responses to microbial pathogens, without the development of auto-inflammatory syndromes. Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address: silke@wehi.edu.au.
authors.forename: John
authors.initials: J
authors.lastname: Silke
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address: vaux@wehi.edu.au.
authors.forename: David L
authors.initials: DL
authors.lastname: Vaux
mesh_terms: D000818:Animals; D020090:Chromosome Segregation; D005246:Feedback; D017353:Gene Deletion; D055786:Gene Knockout Techniques; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D051379:Mice
chemical_list: D051034:Inhibitor of Apoptosis Proteins
keywords: BIR; Birc; Gene deletion; IAP; NAIP; Survivin