title: A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome.
abstract: The aim of this study is to examine the efficacy of alprostadil liposomal preparation in the treatment of blue toe syndrome. As many as 32 patients with blue toe syndrome were randomized into the test group and a control group. Patients out of the test group were treated with alprostadil liposomal preparation, while those out of the control group received placebo administration. Inter-group comparisons were conducted for the post-therapeutic changes of microcirculation and improvements of clinical symptoms. In the test group, there were eight subjects with marked response (50.0 %), six subjects with partial response (37.5 %), and two subjects with no response (12.5 %), with the overall response rate of 87.5 %. In the control group, there were three cases (18.8 %), one case (6.4 %), and 12 cases (75 %), respectively, with the overall response rate of 25.0 %. The inter-group difference of response was statistically significant (Χ (2) = 12.987, P = 0.002 < 0.05). In the test group, there was one case of administration site redness which could be resolved spontaneously. No other adverse drug reactions were reported. No any complaints were reported for the control group. The inter-group difference of nail-fold microcirculation was not statistically significant (P > 0.05). The post-therapeutic points of nail-fold microcirculation in the test group decreased significantly (P < 0.05), but no significant changes were observed for the control group (P > 0.05). The post-therapeutic waveform changes of photoelectric plethysmography were significant for the test group in comparison to the control. The safety and efficacy of alprostadil liposomal preparation have been demonstrated in the treatment of blue toe syndrome.
authors.affiliation: Department of General Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, 221009, Jiangsu, China.
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Xi
authors.affiliation: Department of Central Laboratory, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, 221009, Jiangsu, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of General Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, 221009, Jiangsu, China. tzl910@126.com.
authors.forename: Zhi-Long
authors.initials: ZL
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, 221009, Jiangsu, China.
authors.forename: Su
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of General Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, 221009, Jiangsu, China.
authors.forename: Gao-Lei
authors.initials: GL
authors.lastname: Jia
mesh_terms: D000527:Alprostadil / Q000627:therapeutic use*; D055109:Ankle Brachial Index; D018438:Blue Toe Syndrome / Q000188:drug therapy*; D006801:Humans; D008081:Liposomes / Q000627:therapeutic use*; D008833:Microcirculation / Q000187:drug effects; D020678:Microscopic Angioscopy; D009262:Nails / Q000098:blood supply; D010991:Plethysmography / Q000379:methods; D011446:Prospective Studies; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D008081:Liposomes; D014665:Vasodilator Agents; D000527:Alprostadil
keywords: Alprostadil liposomal preparation; Blue toe syndrome; Nail-fold microcirculation; Photoelectric plethysmography