title: [Correlation analysis of EphA7 expression with clinico-pathological parameters and prognosis in tongue squamous cell carcinoma].
abstract: OBJECTIVE
  To evaluate the relationship between the expression of EphA7 and its clinical correlation and function with tongue squamous cell carcinoma (TSCC).
  
  
  METHODS
  The expression of EphA7 was determined in 54 pairs of human TSCC tissues and pair-matched adjacent noncancerous tissues by immunohistochemistry. Furthermore, association between EphA7 expression and patients' clinicopathological characteristics, overall and disease-free survival were evaluated. Invasion and metastasis of SCC9 cell were detected before and after down regulation of EphA7 expression. Differences in measurement data were compared with paired-t test, and survival analysis was made by Kaplan-Meier method using SPSS17.0 software package.
  
  
  RESULTS
  EphA7 was positive in all examined specimens. Significant associations were noted between high EphA7 expression and absence of lymph node metastasis, absence of vascular invasion, dense stromal inflammatory reaction and female gender. TSCC patients with higher EphA7 expression presented longer overall and disease-free survival compared with low EphA7 expression. The invasion and metastasis of SCC9 cell increased significantly after down regulation of EphA7.
  
  
  CONCLUSIONS
  The study indicated that EphA7 may participate in the malignant transformation of TSCC, reinforcing their utility as targets for potential therapeutic intervention.
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Dalian Medical University. Dalian 116027; Liaoning Province, China.E-mail:donghui760413@sina.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Xiang
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Ying
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Ying
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
mesh_terms: D002294:Carcinoma, Squamous Cell; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D036141:Receptor, EphA7 / Q000096:biosynthesis*; D014062:Tongue Neoplasms
chemical_list: D036141:Receptor, EphA7