title: The place of androgen receptor gene mutation analysis in the molecular diagnosis of prostate cancer and genotype-phenotype relationship.
abstract: OBJECTIVE
  To determine the relationship between androgen receptor (AR) gene polymorphism and prostate cancer in our society.
  
  
  METHODS
  Thirty-nine patients diagnosed with prostate cancer and 34 benign prostatic hyperplasia (BPH) patients who were diagnosed in 2010 met the study criteria. The inclusion criteria included patients whose diagnosis was confirmed with a biopsy, with the presence of adequate pathologic material for review, between the ages of 40 and 80, and who were healthy men without a family history of prostate cancer. The exclusion criteria excluded men diagnosed with another cancer and those who had kin with a history of prostate cancer. A direct DNA sequencing method was utilized for detection of polymorphisms.
  
  
  RESULTS
  CAG repeat length varied from 13 to 28 (mean: 21.67) for the BPH group and 12 to 28 (mean: 21.74) for the prostate cancer group. Prostate-specific antigen (PSA) density and the androgen receptor (AR) CAG repeat had a statistically significant negative correlation in the BPH group. A statistically significant difference was associated between AR CAG repeat and PSA density.
  
  
  CONCLUSIONS
  Randomized prospective studies should be planned with larger patient and control groups and with more variables, which may open new horizons in prostate cancer screening and early detection.
authors.forename: Fuat
authors.initials: F
authors.lastname: Kizilay
authors.forename: Mustafa Serdar
authors.initials: MS
authors.lastname: Kalemci
authors.forename: Adnan
authors.initials: A
authors.lastname: Şimşir
authors.forename: Burak
authors.initials: B
authors.lastname: Turna
authors.forename: Oktay
authors.initials: O
authors.lastname: Nazli
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
mesh_terms: D000368:Aged; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000235:genetics; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000235:genetics; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018911:Trinucleotide Repeats / Q000235:genetics*
chemical_list: D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen