title: Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam.
abstract: Meloxicam (MLX) is a poorly water-soluble non steroidal anti-inflammatory drug (NSAID). The main objective of the present work was to enhance the dissolution of MLX and thus its bioavailability by the aid of additives. The novelty of this work rises from the utilization of spray drying technology to produce micro particulates solid dispersion systems containing MLX in the presence of small amount of additives. Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and Scan Electron Microscope (SEM) were used for studying the physico-chemical and morphological properties of MLX samples. The dissolution of MLX samples was investigated in two different pH media. The morphology of MLX solid dispersion micro-particles was spherical in shape according to SEM. FT-IR profiles indicated that a complex was formed between MLX and the additives. DSC patterns of the MLX micro-particles suggested a reduction in the crystallinity of MLX and probability of presence of an interaction between MLX and the additives. The rate of dissolution of the spray-dried MLX enhanced as compared with the unprocessed MLX in both acidic and neutral media. It was found that 100% of the added MLX released within 5 min in phosphate buffer dissolution medium (pH 7.4) compared to that of the unprocessed MLX (15% in 60 min). Such increase rate in the dissolution of the spray dried MLX could be attributed to the increase in wettability of MLX particles and the hydrophilic nature of the additives. The anti-inflammatory effect of the spray dried MLX was explored using formalin induced rat paw edema model. The spray-dried samples showed an increase in the anti-inflammatory activity of MLX as compared to the unprocessed MLX. This work reveals that the spray drying technique is suitable for preparation of micro-particles with improved dissolution and anti-inflammatory effect of MLX.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Department of Industrial Pharmacy, Faculty of Pharmacy, University of Assiut, Assiut, Egypt.
authors.forename: Gamal
authors.initials: G
authors.lastname: Shazly
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Department of Pharmaceutics, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Badran
authors.affiliation: Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / National Research Center, Cairo, Egypt.
authors.forename: Khairy
authors.initials: K
authors.lastname: Zoheir
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Nanomedicin Unit (NMU-KSU), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alomrani
mesh_terms: D000336:Aerosols; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D002021:Buffers; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D003890:Desiccation; D004195:Disease Models, Animal; D005079:Excipients / Q000737:chemistry; D005557:Formaldehyde; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D000077239:Meloxicam; D008855:Microscopy, Electron, Scanning; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010316:Particle Size; D017208:Rats, Wistar; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods*; D013843:Thiazines / Q000737:chemistry* / Q000494:pharmacology*; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
chemical_list: D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002021:Buffers; D005079:Excipients; D013843:Thiazines; D013844:Thiazoles; D014867:Water; D005557:Formaldehyde; D000077239:Meloxicam