title: Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome.
abstract: OBJECTIVE
  To evaluate whether there is a correlation between insulin resistance and nitric oxide-related endothelial dysfunction in patients with polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  The study was conducted with 25 young women with PCOS and 25 young healthy women, between 18 and 35 years of age. Plasma asymmetric dimethylarginine (ADMA) levels, serum nitric oxide (NO) levels, and homeostatic model assessment of insulin resistance (HOMA-IR) rates were measured in both the patient and control groups.
  
  
  RESULTS
  Plasma ADMA levels were significantly higher in PCOS patients than in the controls (P = 0.001). Serum NO levels were significantly lower in patients than in the controls (P = 0.008). The HOMA-IR rates, accepted as an insulin resistance parameter, were significantly higher in patients than in the controls (P = 0.001).
  
  
  CONCLUSIONS
  Results of the present study indicate that, independent of age, body mass index, and blood lipid profile, there is significant insulin resistance in PCOS patients. However, no correlation was found between HOMA-IR as an insulin resistance determinant and altered ADMA and NO levels. This finding may indicate that there are additional mechanisms of cardiovascular risks in PCOS patients other than insulin resistance.
authors.forename: Mine
authors.initials: M
authors.lastname: Yavuz Taşlipinar
authors.forename: Nedret
authors.initials: N
authors.lastname: Kiliç
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Bayraktar
authors.forename: İsmail
authors.initials: İ
authors.lastname: Güler
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Gülcan Kurt
authors.forename: Tayfun
authors.initials: T
authors.lastname: Göktaş
authors.forename: Mehmet Zeki
authors.initials: MZ
authors.lastname: Taner
authors.forename: Mehmet Özdemir
authors.initials: MÖ
authors.lastname: Hımmetoğlu
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taşlipinar
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015992:Body Mass Index; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009569:Nitric Oxide / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine