title: Inhibition of telomerase activity by NME2: impact on metastasis suppression?
abstract: Though anti-metastatic function of non-metastatic 2 (NME2) has been implicated in multiple cancers, mechanisms of metastases control by NME2 are not clearly understood. Recent observations indicating the involvement of telomerase, the ribonucleoprotein required for telomere synthesis, in metastatic outcome are interesting. Notably, though the role of telomerase dysfunction in tumorigenesis is relatively well studied, involvement in metastasis progression is poorly understood. Recent findings demonstrate NME2 presence at telomere ends, association with telomerase, and NME2's role in inhibition of telomerase activity in cancer cells. These present a novel opportunity to investigate mechanisms underlying NME2-mediated metastasis suppression.
authors.affiliation: Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, DELHI, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Kar
authors.forename: Shantanu
authors.initials: S
authors.lastname: Chowdhury
mesh_terms: D000818:Animals; D006801:Humans; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; C517940:NME2 protein, human; D019098:Telomerase