title: Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats.
abstract: Bisphenol A (BPA) is a commonly used material in daily life, and it is argued to cause oxidative stress in liver and ovarian tissue. α-Lipoic acid (ALA) and α-tocopherol (ATF), two of the most effective antioxidants, may play a role in preventing the toxic effect. Therefore, the purpose of this study was to examine the beneficial effects of ALA, ATF, and that of ALA + ATF combination on oxidative damage induced by BPA. Female Wistar rats were divided into five groups (control, BPA, BPA + ALA, BPA + ATF, and BPA + ALA + ATF). BPA (25 mg/kg/day), ALA (100 mg/kg/day), and ATF (20 mg/kg/day) were administered for 30 days.  The levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), liver malondialdehyde (L-MDA) and glutathione peroxidase (L-GPx), and ovarian malondialdehyde (Ov-MDA) and nitric oxide (Ov-NO) were significantly higher in the BPA-treated groups compared with the control group. The levels of AST and ALT decreased in the BPA + ALA, BPA + ATF, and BPA + ALA + ATF groups compared with the BPA group. Similarly, BPA + ALA or BPA + ATF led to decreases in L-MDA and Ov-MDA levels compared with the BPA group. However, the BPA + ALA + ATF group showed a significant decrease in L-MDA levels compared with the BPA + ALA group and the BPA + ATF group. The levels of L-GPx decreased in the BPA + ATF and the BPA + ALA + ATF groups compared with the BPA group. The administration of ATF and ALA + ATF significantly decreased the Ov-NO levels.  This study demonstrates that BPA causes oxidative damage in liver and ovarian tissues. ALA, ATF, or their combination were found to be beneficial in preventing BPA-induced oxidative stress.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey bahattinavci@hotmail.com.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Avci
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Bahadir
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Ozgur Korhan
authors.initials: OK
authors.lastname: Tuncel
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: Bilgici
mesh_terms: D000284:Administration, Oral; D062107:Advanced Oxidation Protein Products / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000633:toxicity*; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D007247:Infertility, Female / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D010053:Ovary / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011897:Random Allocation; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000627:therapeutic use*; D000098826:Bisphenol A Compounds
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D001559:Benzhydryl Compounds; D015415:Biomarkers; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D008063:Thioctic Acid; D024502:alpha-Tocopherol; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; alpha lipoic acid; alpha tocopherol; oxidative stress