title: [The impact of immunoactive drugs on passive avoidance response].
abstract: OBJECTIVE
  The objective of this project was to explore the influence of immunoactive drugs (tactivin, thymulin, and thymosin fraction 5) on the development of the passive avoidance conditioned reflex.
  
  
  METHODS
  Two types of passive avoidance boxes were used--a regular two-chamber box and a modified three-chamber box, comprising a dark chamber in which rats were exposed to electrical shock, a safe dark chamber, and a light chamber in the center.
  
  
  RESULTS
  The project has established that the memory trace persists longer under the influence of the immunoactive drugs in both models, which is consistent with the reference nootropic piracetam test results. Notably, the immunoactive drugs' mnemotropic effect was more pronounced in the modified three-chamber box than in the standard two-chamber box. Using the modified box helped to establish the influence of tactivin, thymulin, and thymosin fraction 5 on the spatial memory component. Immunotropic preparations from thymus caused the animals to select the safe chamber 24 hours later and in subsequent tests.
  
  
  CONCLUSIONS
  The project's results indicate that the drugs tested do possess mnemotropic properties, so their range of clinical use can be broadened.
authors.forename: A V
authors.initials: AV
authors.lastname: Novoseletskaia
authors.forename: N M
authors.initials: NM
authors.lastname: Kiseleva
authors.forename: O V
authors.initials: OV
authors.lastname: Belova
authors.forename: I V
authors.initials: IV
authors.lastname: Zimina
authors.forename: S N
authors.initials: SN
authors.lastname: Moskvina
authors.forename: O V
authors.initials: OV
authors.lastname: Bystrova
authors.forename: A N
authors.initials: AN
authors.lastname: Inozemtsev
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Arion
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013935:Thymic Factor, Circulating / Q000494:pharmacology; D013947:Thymosin / Q000031:analogs & derivatives / Q000494:pharmacology; D013949:Thymus Extracts / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C033782:thymosin fraction 5; D013947:Thymosin; C036191:T-activin; D013935:Thymic Factor, Circulating