title: MicroRNA-139-3p indicates a poor prognosis of colon cancer.
abstract: MicroRNAs (miRNAs) play an important role in the regulation of gene expression and are involved in almost biological procession. Recently, miR-139-5p has been reported to be downregulated in some types of cancer, and inhibits cancer cell invasion and metastasis. However, there are few reports on the role of miR-139-3p in cancer. In this study, we examined the expression level of miR-139-3p in 63 pairs of colon cancer and adjacent paracancerous tissues using quantitative reverse transcription PCR. The levels of miR-139-3p in colon cancer tissues were significantly lower than those in adjacent noncancerous tissues. There was an inverse correlation between the level of miR-139-3p and patient's age. Lower level of miR-139-3p was significantly associated with poor overall survival, especially in patients with TNM stages I and II. In conclusion, miR-139-3p has potential as a prognostic biomarker for colon cancer. Further prospective studies are required to validate this result.
authors.affiliation: Department of Oncology, Subei People's Hospital, Clinical Medical College of Yangzhou University Yangzhou, Jiangsu, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China.
authors.forename: Bensong
authors.initials: B
authors.lastname: Duan
authors.affiliation: Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, Jilin Agricultural University Changchun, Jilin, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: He
authors.affiliation: CMC Biobank and Translational Medicine Institute Taizhou, Jiangsu, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhou
authors.affiliation: CMC Biobank and Translational Medicine Institute Taizhou, Jiangsu, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Oncology, Subei People's Hospital, Clinical Medical College of Yangzhou University Yangzhou, Jiangsu, China.
authors.forename: Xizhi
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012737:Sex Factors; D015996:Survival Rate
chemical_list: C555098:MIRN139 microRNA, human; D035683:MicroRNAs
keywords: MicroRNA; colon cancer; miR-139; miR-139-3p; prognosis