title: Induced Pluripotent Stem Cells from Nonhuman Primates.
abstract: Induced pluripotent stem cells from nonhuman primates (NHPs) have unique roles in cell biology and regenerative medicine. Because of the relatedness of NHPs to humans, NHP iPS cells can serve as a source of differentiated derivatives that can be used to address important questions in the comparative biology of primates. Additionally, when used as a source of cells for regenerative medicine, NHP iPS cells serve an invaluable role in translational experiments in cell therapy. Reprogramming of NHP somatic cells requires the same conditions as previously established for human cells. However, throughout the process, a variety of modifications to the human cell protocols must be made to accommodate significant species differences.
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Anuja
authors.initials: A
authors.lastname: Mishra
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Farnsworth
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Jacob J
authors.initials: JJ
authors.lastname: Hemmi
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Pickering
authors.affiliation: South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA. hornsby@uthscsa.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hornsby
mesh_terms: D000818:Animals; D002144:Callithrix; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D065150:Cellular Reprogramming; D000067470:Cellular Reprogramming Techniques / Q000379:methods; D005347:Fibroblasts / Q000166:cytology; D016259:Genes, myc; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D050814:Octamer Transcription Factor-3 / Q000235:genetics / Q000502:physiology; D011323:Primates; D020598:Proto-Oncogene Proteins c-myb / Q000502:physiology; D012190:Retroviridae / Q000235:genetics; D055748:SOXB1 Transcription Factors / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D013724:Teratoma / Q000473:pathology; D019076:Transgenes
chemical_list: D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D050814:Octamer Transcription Factor-3; D020598:Proto-Oncogene Proteins c-myb; D055748:SOXB1 Transcription Factors
keywords: Induced pluripotent stem cells; Marmoset; Nonhuman primates; Reprogramming; Retroviruses; Teratoma