title: Phytochemical, Antimicrobial and Antiplasmodial Investigations ofTerminalia brownii.
abstract: Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plantTerminalia browniiled to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3-O-β-D-glucopyranosyl-β-sitosterol. The new compound was identified using spectroscopic methods, notably 1D- and 2D NMR, as 3β,24-O-ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid. The isolated compounds were evaluated for their antimicrobial and antiplasmodial activities. Two compounds with a galloyl group (4and6) were found to be active against chloroquine sensitive (D6) and chloroquine resistant (W2) strains ofPlasmodium falciparum, whereas three ellagic acid derivatives (5-7) were found active against three species of fungi and one species of bacteria.
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
authors.forename: Francis
authors.initials: F
authors.lastname: Machumi
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
authors.forename: Jacob O
authors.initials: JO
authors.lastname: Midiwo
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya ; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya ; Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
authors.forename: Babu L
authors.initials: BL
authors.lastname: Tekwani
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya ; Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.affiliation: National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
authors.forename: Ilias
authors.initials: I
authors.lastname: Muhammad
keywords: 3β, 24-O-Ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid; Antimicrobial; Antiplasmodial; Terminalia brownii