title: Improving ITC studies of cyclodextrin inclusion compounds by global analysis of conventional and non-conventional experiments.
abstract: The study of 1:1 cyclodextrin inclusion compounds by isothermal titration calorimetry was explored in a theoretical and experimental point of view to compare the efficiency of conventional and non-conventional experiments. All direct and competitive protocols were described and evaluated in terms of accuracy on both binding constant and inclusion enthalpy. Significant improvement in the calorimetric characterization may be obtained by means of the global analysis of non-conventional experiments coupled to the standard titration protocol. While the titration-release approach proved to be the most accurate strategy for classical complexations, the valuable contribution of other non-conventional experiments was demonstrated for issues concerning weak stability, enthalpy, or solubility.
authors.affiliation: Univ Lille Nord de France, F-59000 Lille, France ; ULCO, UCEIV, F-59140 Dunkerque, France.
authors.forename: Eléonore
authors.initials: E
authors.lastname: Bertaut
authors.affiliation: Univ Lille Nord de France, F-59000 Lille, France ; ULCO, UCEIV, F-59140 Dunkerque, France.
authors.forename: David
authors.initials: D
authors.lastname: Landy
keywords: cyclodextrins; global analysis; inclusion compounds; isothermal titration calorimetry; non-conventional experiments