title: Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging.
abstract: OBJECTIVE
  To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples.
  
  
  RESULTS
  A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma.
  
  
  CONCLUSIONS
  CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.
authors.forename: Ümmügülsüm
authors.initials: Ü
authors.lastname: Bayraktutan
authors.forename: Abdulmecit
authors.initials: A
authors.lastname: Kantarci
authors.forename: Hayri
authors.initials: H
authors.lastname: Oğul
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Kizrak
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Özyiğit
authors.forename: Zeyneb
authors.initials: Z
authors.lastname: Yüceler
authors.forename: Berhan
authors.initials: B
authors.lastname: Genç
authors.forename: Bünyami
authors.initials: B
authors.lastname: Özoğul
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D011446:Prospective Studies