title: Quantitative liver tumor blood volume measurements by a C-arm CT post-processing software before and after hepatic arterial embolization therapy: comparison with MDCT perfusion.
abstract: OBJECTIVE
  We aimed to determine whether the C-arm computed tomography (CT) blood volume (BV) imaging of hepatic tumors performed with a new prototype software is capable of measuring the BV changes in response to hepatic arterial treatments and to validate these quantitative measurements with commercially available multidetector computed tomography (MDCT) perfusion software.
  
  
  METHODS
  A total of 34 patients with hepatic tumors who underwent either radioembolization (RE, n=21) or transarterial chemoembolization (TACE, n=13) were included in the study. Using a prototype software by Siemens Healthcare, 74 C-arm CT BV measurements were obtained in both pre- and postembolization settings (three patients had additional BV measurements before and after work-up angiography for RE). Ten of 34 patients underwent MDCT perfusion study before embolization, enabling comparison of BV measurements using C-arm CT versus MDCT methods.
  
  
  RESULTS
  The mean BV of 14 tumor lesions in 10 patients on MDCT perfusion was highly correlated with the BV values on C-arm CT (r=0.97, P < 0.01). The BV values obtained by C-arm CT decreased from 140.6±28.3 mL/1000 mL to 45.9±23.5 mL/1000 mL after TACE (66.37% reduction) and from 175.6±29.4 mL/1000 mL to 84.1±22.5 mL/1000 mL after RE (53.75% reduction).
  
  
  CONCLUSIONS
  Quantitative BV measurement with C-arm CT is well-correlated with MDCT BV measurements, and it is a promising tool to monitor perfusion changes during hepatic arterial embolization.
authors.affiliation: Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey. mustafahizal@hotmail.com.
authors.forename: Bora
authors.initials: B
authors.lastname: Peynircioğlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Hızal
authors.forename: Barbaros
authors.initials: B
authors.lastname: Çil
authors.forename: Yu
authors.initials: Y
authors.lastname: Deuerling-Zheng
authors.forename: Martin
authors.initials: M
authors.lastname: Von Roden
authors.forename: Tuncay
authors.initials: T
authors.lastname: Hazırolan
authors.forename: Deniz
authors.initials: D
authors.lastname: Akata
authors.forename: Mustafa
authors.initials: M
authors.lastname: Özmen
authors.forename: Ferhun
authors.initials: F
authors.lastname: Balkancı
mesh_terms: D000328:Adult; D000368:Aged; D001811:Blood Volume Determination; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D012984:Software