title: Investigating the effects of negative-calorie diet compared with low-calorie diet under exercise conditions on weight loss and lipid profile in overweight/obese middle-aged and older men.
abstract: OBJECTIVE
  Negative-calorie diets (NCDs) are among the popular dieting guides for weight loss; however, there is still little knowledge about this method. The present study aimed to determine the effects of a NCD supplemented with exercise on weight loss and lipid profile, and to compare its efficiency with low-calorie diets (LCDs) with exercise among elderly adult men with abnormal weight gain.
  
  
  METHODS
  Participants included sedentary men (aged 45-75 years) who were overweight or obese (n = 37). They were randomly divided into 2 groups: a group with a NCD and exercise, and a group with a LCD with exercise. Of all 37 participants, 30 completed the treatment. Weight assessment parameters, including changes in weight and body composition and blood sample tests, were performed before and 3 months after intervention.
  
  
  RESULTS
  All parameters decreased significantly in both groups. Elevation in high-density lipoprotein (HDL) cholesterol levels (P < 0.001) was different between the 2 groups. The decline in the total cholesterol to HDL cholesterol ratio was greater in the LCD than the NCD group.
  
  
  CONCLUSIONS
  Contrary to expectations, both weight-loss diets were equally efficacious.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Rezaeipour
authors.forename: Gennady Leonidovich
authors.initials: GL
authors.lastname: Apanasenko
authors.forename: Vladimir Ivanovich
authors.initials: VI
authors.lastname: Nychyporuk
mesh_terms: D000368:Aged; D001823:Body Composition / Q000502:physiology; D031204:Caloric Restriction; D008076:Cholesterol, HDL / Q000097:blood; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000503:physiopathology; D050177:Overweight / Q000178:diet therapy* / Q000503:physiopathology*; D057185:Sedentary Behavior; D015431:Weight Loss / Q000502:physiology*
chemical_list: D008076:Cholesterol, HDL