title: Multifocal canalicular adenoma of the minor labial salivary glands.
abstract: Canalicular adenoma (CA) is an uncommon benign neoplasia of salivary glands which is clinically difficult to recognise. Despite having an excellent prognosis, the histological diagnosis and clinical management of this entity can be troublesome. While the main differential diagnosis to consider is basal cell adenoma (BCA), similar histological patterns and multifocality have been observed in adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA), both locally-aggressive malignancies which require radically different treatment to CA. An emphasis has been placed on the value of immunohistochemistry in avoiding diagnostic and surgical errors. CA is positive for AE1/AE3, CD117 and S-100 protein, and negative for p63, α-SMA, Ki 67 and vimentin. Here we discuss the case of a 61-year-old female with CA in her right upper lip, showing multifocal growth histologically. The differential diagnosis with other adenomas is discussed in addition to the role of immunohistochemical studies that can confirm the clinical and surgical findings.
authors.affiliation: Faculty of Dentistry, National University of Cordoba Cordoba, Argentina.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Samar
authors.affiliation: Faculty of Medical Sciences, National University of Cordoba Cordoba, Argentina.
authors.forename: Rodolfo Esteban
authors.initials: RE
authors.lastname: Avila
authors.affiliation: Faculty of Medical Sciences, National University of Cordoba Cordoba, Argentina.
authors.forename: Ismael Bernardo
authors.initials: IB
authors.lastname: Fonseca
authors.affiliation: Department of Pathology, New Cross Hospital, Wolverhampton United Kingdom.
authors.forename: William
authors.initials: W
authors.lastname: Anderson
authors.affiliation: Faculty of Dentistry, National University of Cordoba Cordoba, Argentina ; CIMA Research Group, Faculty of Dentistry, Universidad de La Frontera Temuco, Chile.
authors.forename: Gabriel M
authors.initials: GM
authors.lastname: Fonseca
authors.affiliation: CIMA Research Group, Faculty of Dentistry, Universidad de La Frontera Temuco, Chile ; Doctoral Program in Morphological Sciences, CEMyQ, Faculty of Medicine, Universidad de La Frontera Temuco, Chile ; Center of Research in Biomedical Sciences, Universidad Autónoma de Chile Temuco, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Cantín
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor
keywords: Lip; benign neoplasia; canalicular adenoma; minor salivary glands