title: Whole mitochondrial genome sequencing and analysis for chronic obstructive pulmonary disease rat strain.
abstract: Mitochondrial genome plays a central role in aging, cancer, apoptosis and metabolism. We sequenced a complete mitochondrial genome sequence of a rat chronic obstructive pulmonary disease rat strain for the first time. The total length of the mitochondrial genome was 16,310 bp and coding 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes. This genome describing information will supply the potential use of mtDNA mutations as markers in cancer.
authors.affiliation: a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Jiang
authors.affiliation: b Department of Thoracic Surgery , The People's Hospital of Linyi , Linyi , China.
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Zhao
authors.affiliation: a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Xu
authors.affiliation: a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
authors.forename: Jian
authors.initials: J
authors.lastname: Jie
authors.affiliation: a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
authors.forename: Zhong-Hui
authors.initials: ZH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018387:Codon, Initiator; D018388:Codon, Terminator; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D054629:Genome, Mitochondrial; D009245:NADH Dehydrogenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016366:Open Reading Frames / Q000235:genetics; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000473:pathology; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics; D051381:Rats; D017422:Sequence Analysis, DNA
chemical_list: D018387:Codon, Initiator; D018388:Codon, Terminator; D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; D012343:RNA, Transfer; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV
keywords: Cancer; chronic obstructive pulmonary disease; mitochondrial genome