title: CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors.
abstract: BACKGROUND
  Management of spinal neoplasms has relied on open surgery and external beam radiotherapy (EBRT). Although primary spinal tumors are rare, their treatment remains a pervasive problem. This analysis sought to evaluate the safety and efficacy of CT-guided (125)I seed brachytherapy for recurrent paraspinous and vertebral primary tumors.
  
  
  METHODS
  From November 2002 to June 2014, 17 patients who met the inclusion criteria were retrospectively reviewed. 14 (82.4%) had previously undergone surgery, 15 (88.2%) had received conventional EBRT and 3 (17.6%) had chosen chemotherapy. The number of (125)I seeds implanted ranged from 7 to 122 (median 79) with specific activity of 0.5-0.8 mCi (median 0.7 mCi). The post-plan showed that the actuarial D90 of (125)I seeds were 90-183 Gy (median 137 Gy). The follow-up period ranged from 2 to 69 months (median 19 months). The local control rate was calculated by the Kaplan-Meier method.
  
  
  RESULTS
  For 5 Chondrosarcomas, the 1-, 2-, 3-year local control rates were 75%, 37.5%, and 37.5%, respectively, with a median of 34 months (range, 4-39 months). For 4 chordomas, the local control rate was 50% with a median follow-up of 13 months (range, 3-17 months). For 3 fibromatosis, all of them were survival without local recurrence at the end of follow-up. During the follow-up period, 35.3% (6/17) died from metastases, 17.6% (3/17) developed local recurrence by 8, 14 and 34 months while 64.7% (11/17) remained alive. 100% experienced pain relief and normal or improved ambulation, without more than Frankel grade 3 radiation myelopathy.
  
  
  CONCLUSIONS
  Percutaneous (125)I seed implantation can be an alternative or retreatment for recurrent spinal primary tumors.
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. qqconstance@163.com.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. hhbysy@126.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. Na0502@hotmail.com.
authors.forename: Na
authors.initials: N
authors.lastname: Meng
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. radiotherapy@sina.com.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. drjiangping@gmail.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. Gaoyang100191@gmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. Tumc123@sina.com.
authors.forename: Suqing
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of Radiology, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. doctorliuchen@163.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. ruijyang@yahoo.com.
authors.forename: Ruijie
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, Cancer center, Peking University Third Hospital, No. 49 North Garden road, Haidian district, Beijing, 100191, China. junjiewang_edu@sina.cn.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Cancer Center, Tengzhou Central People's Hospital, Tengzhou city, Shangdong Province, 277500, China. kaixianzhang@aliyun.com.
authors.forename: Kaixian
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D061089:Radiotherapy, Image-Guided / Q000379:methods; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D013125:Spinal Neoplasms / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes