title: Mitral annular plane systolic excursion in the assessment of left ventricular diastolic dysfunction in obese adults.
abstract: OBJECTIVE
  Mitral annular plane systolic excursion (MAPSE) is a simple way to assess left ventricle (LV) function. MAPSE is also correlated to parameters, illustrating the close relation between systolic and diastolic function of LV. In this study, we evaluated whether MAPSE could help us in the determination the LV diastolic dysfunction (DD) in obese adults.
  
  
  METHODS
  Our study was a prospective cross-sectional study. Obese patients who were referred from the endocrinology clinic were enrolled into this study. The participants included 40 obese patients with early-stage DD (grade I and II) and 40 obese patients with normal diastolic function, with an equal number of males and females. The patients with DD were further divided into Obese DD+I, who had grade I DD, and Obese DD+II, who had grade II DD. Student t-test, Mann-Whitney U test, one-way analysis of variance, ROC curve analysis, and pairwise comparisons of the ROC curves were used for statistical analysis.
  
  
  RESULTS
  MAPSE was different in all groups, with the lowest value in the Obese DD+II group (p<0.001). E/Em ratio was also different among all groups and was highest in the Obese DD+II group (p<0.001). Furthermore, MAPSE was negatively correlated with E/Em ratio (r=-0.368, p=0.020). The optimal threshold point of MAPSE in the diagnosis of left ventricle diastolic dysfunction (LVDD) was ≤1.45 cm, with 92.5% sensitivity (95% CI 79.6-98.4) and 77.5% specificity (95% CI 61.5-89.2) in the ROC curve analysis. There was no difference in the pairwise comparisons of the ROC curves of MAPSE and E/Em ratio in the diagnosis of DD [area under the ROC curve 0.902 (0.033) vs. 0.927 (0.027); p=0.54].
  
  
  CONCLUSIONS
  Consequently, we found significantly a close relationship between MAPSE with conventional echocardiographic parameters, especially with E/Em, in the detection of left ventricle diastolic dysfunction (LVDD) in obese adults with normal LV ejection fraction. We think that MAPSE is a simple, easily acquired and less time consuming measurement and may help us in the stratification of LVDD in obese adults.
authors.affiliation: Department of Cardiology, Adıyaman University, Training and Research Hospital; Adıyaman-Turkey. hakantasolar@gmail.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Taşolar
authors.forename: Türkan
authors.initials: T
authors.lastname: Mete
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çetin
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ballı
authors.forename: Adil
authors.initials: A
authors.lastname: Bayramoğlu
authors.forename: Yılmaz Ömür
authors.initials: YÖ
authors.lastname: Otlu
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D009767:Obesity, Morbid; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*