title: Biological adhesive based on carboxymethyl chitin derivatives and chitin nanofibers.
abstract: Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hydrogen peroxide solution as a radical initiator. The adhesive strength of HMA-CM-chitin increased when it was blended with chitin nanofibers (CNFs) or surface-deacetylated chitin nanofibers (S-DACNFs). HMA-CM-chitin/CNFs or HMA-CM-chitin/S-DACNFs have almost equal adhesive strength compared to that of a commercial cyanoacrylate adhesive. Moreover, quick adhesion and induction of inflammatory cells migration were observed in HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF. These findings indicate that the composites prepared in this study are promising materials as new biological adhesives.
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan. Electronic address: kazu-azuma@muses.tottori-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishihara
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Shimizu
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Itoh
authors.affiliation: Scientific Crime Laboratory, Tottori Prefectural Police H. Q., Tottori 680-0911, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Takashima
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Itoh
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murahata
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan. Electronic address: morimoto@chem.tottori-u.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
mesh_terms: D000269:Adhesives / Q000494:pharmacology*; D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003487:Cyanoacrylates / Q000737:chemistry; D005260:Female; D007958:Leukocyte Count; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011312:Pressure; D017208:Rats, Wistar; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D000269:Adhesives; D003487:Cyanoacrylates; D008689:Methacrylates; D002686:Chitin; C044872:O-(carboxymethyl)chitin
keywords: 2-Hydroxy-3-methacryloyloxypropylated carboxymethyl chitin; Adhesion; Chitin; Chitin nanofiber