title: A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history.
abstract: OBJECTIVE
  This study compares the frequency of adverse transfusion reactions (ATRs) after first transfusions with the frequency of ATRs for subsequent (non-first) transfusions.
  
  
  METHODS
  Five hospitals agreed to systematically collect and share 2 years of data. This was a retrospective observational analysis of data including the number of transfusion episodes and ATRs for red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PCs) given to first-time transfusion recipients and to those previously transfused.
  
  
  RESULTS
  First transfusion ATRs to RBCs, FFP and PCs were 1.08%, 2.84% and 3.34%, respectively. These are higher than ATR incidences to RBCs (0.69%), FFP (1.91%) and PCs (2.75%) on subsequent transfusions. Specifically, first transfusion incidences of febrile non-haemolytic transfusion reactions (FNHTRs) to RBCs (0.43%) and allergic reactions to FFP (2.51%) were higher than on subsequent transfusions (RBCs: 0.23%, FFP: 1.65%).
  
  
  CONCLUSIONS
  There are risks of ATRs on the first transfusion as well as transfusions of patients with transfusion history.
authors.affiliation: Department of Transfusion Medicine, Aichi Medical University, Nagakute, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Uruma
authors.forename: Y
authors.initials: Y
authors.lastname: Okuyama
authors.forename: M
authors.initials: M
authors.lastname: Handa
authors.forename: Y
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: S
authors.initials: S
authors.lastname: Shimodaira
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
mesh_terms: D001803:Blood Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D065227:Transfusion Reaction / Q000453:epidemiology* / Q000209:etiology
keywords: adverse transfusion reaction; allergic reaction; first transfusion; haemovigilance; transfusion episode