title: Gene therapy in dentistry: tool of genetic engineering. Revisited.
abstract: Advances in biotechnology have brought gene therapy to the forefront of medical research. The concept of transferring genes to tissues for clinical applications has been discussed nearly half a century, but the ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. The feasibility of gene transfer was first demonstrated using tumour viruses. This led to development of viral and nonviral methods for the genetic modification of somatic cells. Applications of gene therapy to dental and oral problems illustrate the potential impact of this technology on dentistry. Preclinical trial results regarding the same have been very promising. In this review we will discuss methods, vectors involved, clinical implication in dentistry and scientific issues associated with gene therapy.
authors.affiliation: Faculty of Dentistry, AIMST University, Semeling, Bedong 08100, Kedah, Malaysia. Electronic address: hitokhushi@gmail.com.
authors.forename: Khushboo
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Faculty of Dentistry, AIMST University, Semeling, Bedong 08100, Kedah, Malaysia. Electronic address: drsaurabhomfs@gmail.com.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Oral Pathology, Chandra Dental College and Hospital, Barabanki, Lucknow, India. Electronic address: Drkavitanitish@rediffmail.com.
authors.forename: Kavita Nitish
authors.initials: KN
authors.lastname: Garg
mesh_terms: D003813:Dentistry; D005818:Genetic Engineering; D015316:Genetic Therapy; D006801:Humans
keywords: Clinical implication; Dentistry; Gene therapy