title: Gleason score at the margin can predict biochemical recurrence after radical prostatectomy, in addition to preoperative PSA and surgical margin status.
abstract: OBJECTIVE
  To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels.
  
  
  METHODS
  A total of 94 patients who underwent radical prostatectomy were recruited for this study and received postoperative follow-up care for 2 years. All specimens were evaluated for surgical margin status, PSM length, GS at positive margin, size of tumor, multifocality, invasion of seminal vesicle, lymphovascular invasion, and perineural invasion. PSM was defined as a prostate tumor.
  
  
  RESULTS
  Out of 94 patients, 34 patients (36.2%) had PSMs and 46 patients (48.9%) had BCR. A statistically significant relation between having a high risk of BCR of prostate cancer and having high preoperative PSA levels (P < 0.001), PSMs (P < 0.001), or a high GS at the surgical margin (P = 0.024) was found.
  
  
  CONCLUSIONS
  High preoperative PSA levels, PSMs, and tumors with high GS at the margins have a poor prognostic impact, and they correlate with a higher rate of BCR. Close follow-up of patients with PSMs with high GS and high levels of preoperative PSA is recommended.
authors.affiliation: Department of Pathology, Göztep Training and Research Hospital, İstanbul Medeniyet University, İstanbul,  Turkey. seymaozkanli@gmail.com
authors.forename: Sidlka Şeyma
authors.initials: SŞ
authors.lastname: Özkanli
authors.forename: Itlr Ebru
authors.initials: IE
authors.lastname: Zemher
authors.forename: Aslf
authors.initials: A
authors.lastname: Yildirim
authors.forename: Hatice Deniz
authors.initials: HD
authors.lastname: Gür
authors.forename: Mevlana Derya
authors.initials: MD
authors.lastname: Balbay
authors.forename: Serkan
authors.initials: S
authors.lastname: Şenol
authors.forename: Ahmet Oğuz
authors.initials: AO
authors.lastname: Özkanli
authors.forename: Erdal
authors.initials: E
authors.lastname: Alkan
authors.forename: Tülay
authors.initials: T
authors.lastname: Zenginkinet
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydin
authors.forename: Turhan
authors.initials: T
authors.lastname: Çaşkurlu
mesh_terms: D000368:Aged; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology*; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen