title: The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients.
abstract: OBJECTIVE
  To investigate the association of Sirtuin 3 (SIRT 3) expression between the clinical characteristics and prognosis in breast cancer patients.
  
  
  METHODS
  308 female patients with histologically confirmed breast cancer were enrolled in this study. The SIRT 3 expressions in tumor samples were detected. All the patients were followed up overall survival time (OS) and disease-free survival (DFS) time.
  
  
  RESULTS
  SIRT 3 expression was significantly correlated with clinical characteristics including lymph node metastasis, pathological grade and tumor size of breast cancer. SIRT 3 expression status also affected the DFS and OS of breast cancer. Patients with high expression of SIRT 3 had shorter DFS and OS than those with low expression. Univariate and multivariate Cox analyses confirmed that high SIRT 3 expression predicted a poor prognosis in breast cancer patient. In vitro study revealed that the SIRT 3 knockdown by small interfering RNA technique dramatically reduced the proliferation, migration and invasion of breast cancer cell lines.
  
  
  CONCLUSIONS
  Our results suggest that SIRT 3 may serve as a marker for clinical feature and prognosis for breast cancer.
authors.affiliation: Departent of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Shaozhong
authors.initials: S
authors.lastname: He
authors.forename: Chun
authors.initials: C
authors.lastname: He
authors.forename: Hua
authors.initials: H
authors.lastname: Yuan
authors.forename: Shizhong
authors.initials: S
authors.lastname: Xiong
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Xiao
authors.forename: Longhua
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D056566:Sirtuin 3 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C466093:SIRT3 protein, human; D056566:Sirtuin 3