title: CT-guided fine-needle aspiration and core needle biopsies of pulmonary lesions: a single-center experience with 750 biopsies in Japan.
abstract: OBJECTIVE
  CT-guided lung biopsy is a well-established diagnostic method for pulmonary lesions. The aim of our study was to evaluate the diagnostic outcomes and safety profile of conventional CT-guided lung biopsies.
  
  
  METHODS
  We retrospectively analyzed the results of CT-guided lung biopsies for 750 patients to determine the diagnostic accuracy, complication rates, and independent risk factors for diagnostic failure and severe pneumothorax.
  
  
  RESULTS
  Diagnostic accuracy was 92.9%. Independent risk factors for diagnostic failure were malignant lesions (odds ratio [OR], 4.20; 95% CI, 1.66-14.1; p = 0.001), lesions in the lower lobe (OR, 2.01; 95% CI, 1.17-3.47; p = 0.011), lesions 2.0 cm or smaller (OR, 2.87; 95% CI, 1.59-5.48; p < 0.001), and the presence of pneumothorax during the procedure (OR, 2.18; 95% CI, 1.27-3.78; p = 0.004). Pneumothorax requiring drainage occurred in 7% of patients. Independent risk factors for pneumothorax requiring drainage were age of 73 years or older (OR, 2.19; 95% CI, 1.21-4.05; p = 0.009), the presence of emphysema (OR, 4.29; 95% CI, 2.05-8.82; p < 0.001), benign lesions (OR, 2.33; 95% CI, 1.20-4.40; p = 0.012), supine positioning of the patient (OR, 2.61; 95% CI, 1.44-4.84; p = 0.001), and length from the pleura to the lesion of 1.5 cm or greater (OR, 3.08; 95% CI, 1.63-6.17; p < 0.001).
  
  
  CONCLUSIONS
  CT-guided lung biopsy has a high diagnostic accuracy. Complication rates were acceptable and comparable to those of previous studies.
authors.affiliation: 1 All authors: Division of Integrated Oncology, Institute of Biomedical Research and Innovation, 2-2, Minatojima-Minamimachi, Chuo-Ku, Kobe, Hyogo 650-0047, Japan.
authors.forename: Jumpei
authors.initials: J
authors.lastname: Takeshita
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Masago
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kato
authors.forename: Akito
authors.initials: A
authors.lastname: Hata
authors.forename: Reiko
authors.initials: R
authors.lastname: Kaji
authors.forename: Shiro
authors.initials: S
authors.lastname: Fujita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Katakami
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000706:statistics & numerical data*; D062005:Biopsy, Large-Core Needle / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*
keywords: CT-guided lung biopsy; core needle biopsy; fine-needle aspiration; pneumothorax; pulmonary lesion