title: One pot synthesis of poly(5-hydroxyl-1,4-naphthoquinone) stabilized gold nanoparticles using the monomer as the reducing agent for nonenzymatic electrochemical detection of glucose.
abstract: Monodispersed and highly stable gold nanoparticles with a diameter between 8 and 9 nm were synthesized in a weakly alkaline medium by chemical reduction of AuCl4(-) using 5-hydroxyl-1,4-naphthoquinone, and stabilized by the simultaneously formed poly(hydroxyl-1,4-naphthoquinone). The electrochemical properties of the resultant poly(hydroxyl-1,4-naphthoquinone) stabilized gold nanoparticles (AuNQ NPs) and its electrocatalytic activity for glucose oxidation in alkaline media were then investigated using a range of techniques, including dc cyclic, rotating disk electrode and Fourier transformed large amplitude ac voltammetry. The results demonstrate that these AuNQ NP modified electrodes exhibit excellent catalytic activity toward glucose oxidation in the potential region where the premonolayer oxidation process occurs. The overall catalytic glucose oxidation process was found to be mass transport controlled under the experimental conditions employed, allowing measurements to be conducted with a high reproducibility. The AuNQ NP modified electrodes showed a high sensitivity of 183 μA mM(-1) cm(-2) with a wide linear dynamic range of 0.5-50 mM and a detection limit of 61 μM. However, despite its excellent tolerance toward ascorbic acid, significant interference from uric acid was found with this AuNQ NP modified electrode.
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: M C Dilusha
authors.initials: MC
authors.lastname: Cooray
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Langford
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Bond
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia. Electronic address: jie.zhang@monash.edu.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D060326:Chemistry Techniques, Synthetic; D004355:Drug Stability; D004553:Electric Conductivity; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D017612:Gold Compounds / Q000737:chemistry; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D019163:Reducing Agents / Q000737:chemistry*
chemical_list: D017612:Gold Compounds; D009285:Naphthoquinones; D011108:Polymers; D019163:Reducing Agents; C038016:gold chloride; D006046:Gold; D005947:Glucose; C005134:juglone
keywords: Electrochemical; Glucose; Gold nanoparticle; Naphthoquinone; Nonenzymatic; Polymer