title: Autophagic regulation of smooth muscle cell biology.
abstract: Autophagy regulates the metabolism, survival, and function of numerous cell types, including those comprising the cardiovascular system. In the vasculature, changes in autophagy have been documented in atherosclerotic and restenotic lesions and in hypertensive vessels. The biology of vascular smooth muscle cells appears particularly sensitive to changes in the autophagic program. Recent evidence indicates that stimuli or stressors evoked during the course of vascular disease can regulate autophagic activity, resulting in modulation of VSMC phenotype and viability. In particular, certain growth factors and cytokines, oxygen tension, and pharmacological drugs have been shown to trigger autophagy in smooth muscle cells. Importantly, each of these stimuli has a redox component, typically associated with changes in the abundance of reactive oxygen, nitrogen, or lipid species. Collective findings support the hypothesis that autophagy plays a critical role in vascular remodeling by regulating smooth muscle cell phenotype transitions and by influencing the cellular response to stress. In this graphical review, we summarize current knowledge on the role of autophagy in the biology of the smooth muscle cell in (patho)physiology.
authors.affiliation: Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY, USA; Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Joshua K
authors.initials: JK
authors.lastname: Salabei
authors.affiliation: Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY, USA; Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA; Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA; Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA. Electronic address: bradford.hill@louisville.edu.
authors.forename: Bradford G
authors.initials: BG
authors.lastname: Hill
mesh_terms: D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001343:Autophagy / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics
keywords: Atherosclerosis; Autophagy; Metabolism; Oxidative stress; Platelet-derived growth factor; Restenosis