title: Brain function predictors and outcome of weight loss and weight loss maintenance.
abstract: Obesity rates are associated with public health consequences and rising health care costs. Weight loss interventions, while effective, do not work for everyone, and weight regain is a significant problem. Eating behavior is influenced by a convergence of processes in the brain, including homeostatic factors and motivational processing that are important contributors to overeating. Initial neuroimaging studies have identified brain regions that respond differently to visual food cues in obese and healthy weight individuals that are positively correlated with reports of hunger in obese participants. While these findings provide mechanisms of overeating, many important questions remain. It is not known whether brain activation patterns change after weight loss, or if they change differentially based on amount of weight lost. Also, little is understood regarding biological processes that contribute to long-term weight maintenance. This study will use neuroimaging in participants while viewing food and non-food images. Functional Magnetic Resonance Imaging will take place before and after completion of a twelve-week weight loss intervention. Obese participants will be followed though a 6-month maintenance period. The study will address three aims: 1. Characterize brain activation underlying food motivation and impulsive behaviors in obese individuals. 2. Identify brain activation changes and predictors of weight loss. 3. Identify brain activation predictors of weight loss maintenance. Findings from this study will have implications for understanding mechanisms of obesity, weight loss, and weight maintenance. Results will be significant to public health and could lead to a better understanding of how differences in brain activation relate to obesity.
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, United States.
authors.forename: Amanda N
authors.initials: AN
authors.lastname: Szabo-Reed
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, United States.
authors.forename: Florence J
authors.initials: FJ
authors.lastname: Breslin
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, United States.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Lynch
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, United States.
authors.forename: Trisha M
authors.initials: TM
authors.lastname: Patrician
authors.affiliation: Department of Preventive Medicine & Public Health, University of Kansas Medical Center, United States; Holgund Brain Imaging Center, University of Kansas Medical Center, United States.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Martin
authors.affiliation: Holgund Brain Imaging Center, University of Kansas Medical Center, United States.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Lepping
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, United States.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Powell
authors.affiliation: Department of Biostatistics, University of Kansas Medical Center, United States.
authors.forename: Hung-Wen Henry
authors.initials: HW
authors.lastname: Yeh
authors.affiliation: Department of Preventive Medicine & Public Health, University of Kansas Medical Center, United States.
authors.forename: Christie A
authors.initials: CA
authors.lastname: Befort
authors.affiliation: Department of Dietetics and Nutrition, University of Kansas Medical Center, United States.
authors.forename: Debra
authors.initials: D
authors.lastname: Sullivan
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, United States.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Gibson
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Washburn
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, United States.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Donnelly
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, United States. Electronic address: csavage@kumc.edu.
authors.forename: Cary R
authors.initials: CR
authors.lastname: Savage
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D015992:Body Mass Index; D001837:Body Weights and Measures; D001921:Brain / Q000502:physiology*; D004032:Diet; D015444:Exercise; D030141:Feedback, Psychological; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D006040:Goals; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009765:Obesity; D012107:Research Design; D012944:Social Support; D015431:Weight Loss; D061217:Weight Reduction Programs / Q000379:methods*
keywords: Functional Magnetic Resonance Imaging; Obesity; Weight loss