title: Evaluation of colorectal cancers for Lynch syndrome: practical molecular diagnostics for surgical pathologists.
abstract: Lynch syndrome is the most common inherited colorectal cancer syndrome, accounting for 2-4% of all colorectal cancer cases. This review focuses on the tissue workup of Lynch syndrome, including methods to determine whether or not a tumor is mismatch repair deficient, and whether a mismatch repair-deficient tumor is sporadic or Lynch syndrome-associated. Strategies for determining which tumors to test and how best to implement a Lynch syndrome screening program are also discussed, as well as potential developments in the future.
authors.affiliation: Department of Pathology, University Medical Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Wade S
authors.initials: WS
authors.lastname: Samowitz
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D057089:Pathology, Molecular / Q000379:methods*; D010340:Pathology, Surgical / Q000379:methods*