title: Severe Hypocalcemia Associated With Denosumab in Metastatic Castration-Resistant Prostate Cancer: Risk Factors and Precautions for Treating Physicians.
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: autiok@mskcc.org.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Autio
authors.affiliation: Department of Medicine, Endocrinology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Azeez
authors.initials: A
authors.lastname: Farooki
authors.affiliation: Department of Medicine, Renal Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Ilya G
authors.initials: IG
authors.lastname: Glezerman
authors.affiliation: Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Amelia
authors.initials: A
authors.lastname: Chan
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Coursen W
authors.initials: CW
authors.lastname: Schneider
authors.affiliation: Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Hallie C
authors.initials: HC
authors.lastname: Barr
authors.affiliation: Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Seyboth
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Kampel
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Danila
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rathkopf
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Susan F
authors.initials: SF
authors.lastname: Slovin
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Howard I
authors.initials: HI
authors.lastname: Scher
authors.affiliation: Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Morris
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002118:Calcium / Q000008:administration & dosage*; D000069448:Denosumab / Q000008:administration & dosage / Q000009:adverse effects*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D000069448:Denosumab; D002118:Calcium
keywords: Denosumab; Hypocalcemia; Metastatic prostate cancer; Osteoclast; RANKL; Skeletal-related event