title: Mitotically active cellular fibroma of ovary should be differentiated from fibrosarcoma: a case report and review of literature.
abstract: The clinicopathologic characteristic of mitotically active cellular fibroma is significantly different from the malignant behavior of ovarian fibrosarcoma. Therefore, it's very important to differentiate mitotically active cellular fibroma from ovarian fibrosarcoma. We report a case in which a 39-year-old woman was found with an ovarian tumor measuring 105 × 71 × 47 mm. The tumor ruptured and adhered to the peritoneum. Microscopic examination showed densely cellular spindle-shaped tumor cells. The cellular atypia was mild. The Ki-67 proliferation index was approximately 10%. The patient remained free of tumor for more than 66 months without any adjuvant chemotherapy after operation. After reviewing the literature, we diagnosed this case as mitotically active cellular fibroma rather than ovarian fibrosarcoma. It is very important to differentiate these two tumors because of the marked differences in treatment modalities and prognosis between them. The ovarian fibrous tumors with mitotic figures ≥ 4 per 10 high-power fields but no severe nuclear atypia should be mostly diagnosed as mitotically active cellular fibroma of ovary. The correct diagnosis is the key to avoid excessive treatments.
authors.affiliation: Department of Gynecology, Nanshan Hospital Afflicated to Guangdong Medical College Shenzhen, Guangdong Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zong
authors.affiliation: Department of Pathology, Nanshan Hospital Afflicated to Guangdong Medical College Shenzhen, Guangdong Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lin
authors.affiliation: Health Science Center, Shenzhen University Shenzhen, China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Fan
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology*; D005354:Fibrosarcoma / Q000473:pathology*; D006801:Humans; D008940:Mitotic Index; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*; D011379:Prognosis
keywords: Mitotically active cellular fibroma of ovary; ovarian fibrosarcoma; ovarian fibrous tumor