title: Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats.
abstract: In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China; Department of Obstetrics and Gynecology, First People's Hospital of Yunnan Province, Kunming 650032, PR China.
authors.forename: Yiqin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: He
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
authors.forename: Xiaochao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
authors.forename: Renhua
authors.initials: R
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China; Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, PR China.
authors.forename: Shude
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Yunnan University of Traditional Chinese Medicine, Kunming 650050, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yun
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China; Department of Pharmacology, Yunnan University of Traditional Chinese Medicine, Kunming 650050, PR China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China. Electronic address: ynkmcp@gmail.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China. Electronic address: shzhq21cn@qq.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005960:Glucosides; D047348:Hydrolyzable Tannins; D004958:Estradiol; C024603:Geraniin; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Biomechanics; Bone turnover; Geraniin; Ovariectomy-induced osteoporosis