title: Tricin derivatives as anti-inflammatory and anti-allergic constituents from the aerial part of Zizania latifolia.
abstract: Methanol extract of Zizania latifolia was partitioned with EtOAc, n-BuOH, and H2O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, tricin (1), salcolin A (2), salcolin B (3), and salcolin C (4), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be tricin-4'-O-[erythro-β-guaiacyl-(7″-O-methyl)-glyceryl] ether and was named salcolin D (5) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2-5, tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than tricin. In particular, salcolin D (5) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as β-hexosaminidase release in IgE-sensitized RBL-2H3 cells. These results suggest that the presence of tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.
authors.affiliation: a Graduate School of Biotechnology and Research Institute of Life Science & Resources , Kyung Hee University , Yongin-si , Korea.
authors.forename: Seung-Su
authors.initials: SS
authors.lastname: Lee
authors.forename: Yoon-Su
authors.initials: YS
authors.lastname: Baek
authors.forename: Cheong-Su
authors.initials: CS
authors.lastname: Eun
authors.forename: Mi-Hee
authors.initials: MH
authors.lastname: Yu
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Dae-Kyun
authors.initials: DK
authors.lastname: Chung
authors.forename: Myun-Ho
authors.initials: MH
authors.lastname: Bang
authors.forename: Seun-Ah
authors.initials: SA
authors.lastname: Yang
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D044947:Flavonolignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007073:Immunoglobulin E / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D006109:Poaceae / Q000737:chemistry*; D051381:Rats; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D047309:Flavones; D005419:Flavonoids; D044947:Flavonolignans; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; C000590571:salcolin A; C000607298:salcolin C; C000607299:salcolin D; D009569:Nitric Oxide; D007073:Immunoglobulin E; C017769:tricin; D001619:beta-N-Acetylhexosaminidases
keywords: Zizania latifolia; anti-allergy; anti-inflammation; new flavonolignan; salcolin; tricin