title: Prenatal Diagnosis and Postnatal Outcome of Schizencephaly.
abstract: The aim of this study was to present our experience with 5 cases of fetal schizencephaly in terms of prenatal diagnostic features, and postnatal outcome. The database of prenatal diagnosis unit was searched for antenatally diagnosed cases with schizencephaly. Maternal characteristics, ultrasonography, prenatal-postnatal magnetic resonance imaging (MRI) findings, and postnatal outcome were noted. Of 5 cases, 2 had definitive prenatal diagnoses on ultrasound and 3 cases were diagnosed by fetal MRI. All cases had cerebral cortical migration anomalies including polymicrogyria, subependymal heterotopia, and lissencephaly, and 2 cases had additional extracranial malformations. Three cases showed regression of the cerebral clefts on follow-up postnatal MRIs. Three cases had moderate to severe psychomotor retardation, and 1 case needed repeated ventriculoperitoneal shunt operation due to hydrocephaly. Prenatal diagnosis of schizencephaly with ultrasonography is not straightforward and required further evaluation with fetal MRI. Additional cerebral anomalies worsen the prognosis of schizencephaly.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet Serdar
authors.initials: MS
authors.lastname: Kutuk
authors.affiliation: Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey drburcugorkem@gmail.com.
authors.forename: Sureyya Burcu
authors.initials: SB
authors.lastname: Gorkem
authors.affiliation: Department of Paediatric Neurology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Bayram
authors.affiliation: Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Doganay
authors.affiliation: Department of Paediatric Neurology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Canpolat
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Basbug
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D065707:Schizencephaly / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D016216:Ultrasonography, Prenatal; D055815:Young Adult
keywords: Schizencephaly; magnetic resonance imaging; prenatal; ultrasonography