title: MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma.
abstract: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose of this study was for us to identify and functionally characterize miRNAs that predict recurrence in OSCC.
  
  
  
  We collected 92 OSCC with their normal tissue counterparts and we performed miRNAs expression profiling on 74 OSCC and 38 normal tissues. The association between the expression of miRNAs and clinical outcome was evaluated in the follow-up of 69 patients.
  
  
  
  Four of the miRNAs deregulated between OSCC and normal tissues are prognostic for recurrence either when considered individually or as a group. Depletion of the expression of prognostic miRNAs inhibit the proliferation of OSCC cells
  
  
  
  MiRNAs are differentially expressed in OSCC versus normal samples. The expression of 4 prognostic miRNA signatures is able to predict recurrence risk independently from other clinical factors in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E189-E197, 2016.
authors.affiliation: Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Ganci
authors.affiliation: Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sacconi
authors.affiliation: Otolaryngology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Manciocco
authors.affiliation: Biostatistical Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Sperduti
authors.affiliation: Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.affiliation: Pathology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Covello
authors.affiliation: Department of Oncology, Juravinski Cancer Center-McMaster University Hamilton, Ontario, Canada.|School of Public Health-Harvard University, Boston, Massachusetts.
authors.forename: Paola
authors.initials: P
authors.lastname: Muti
authors.affiliation: Molecular Chemoprevention Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Strano
authors.affiliation: Otolaryngology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spriano
authors.affiliation: Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Fontemaggi
authors.affiliation: Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis
chemical_list: D035683:MicroRNAs
keywords: microRNA; oral squamous cell carcinoma (OSCC); prognosis; recurrence; signature