title: [Single-cell sequencing and tumour heterogeneity].
abstract: The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern of point mutations. This extensive genetic diversity is present before any treatment, and is likely to cause resistance to initially successful targeted therapies.
authors.affiliation: UMR 7268 ADÉS, Aix-Marseille Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d'adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France - CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jordan
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D002477:Cells / Q000737:chemistry*; D018740:Genetic Heterogeneity; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D017354:Point Mutation; D059010:Single-Cell Analysis