title: Solid-supported hydrazone of 4-(4'-formyl-3'-methoxyphenoxy)butyric acid as a new traceless linker for solid-phase synthesis.
abstract: The use of a hydrazine derived from a backbone amide linker as a new hydrazone-based traceless linker for solid-phase organic synthesis is described. The stability of the linker was tested under various conditions, including treatment with acids, bases, and borohydrides. Final compounds can be released by selective cleavage using trimethylsilanolate. To demonstrate the versatility of the linker, the synthesis of a model compound under various reaction conditions was performed with good results.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Palacký University , 771 46 Olomouc, Czech Republic.
authors.forename: Sergei
authors.initials: S
authors.lastname: Okorochenkov
authors.forename: Kristyna
authors.initials: K
authors.lastname: Burglova
authors.forename: Igor
authors.initials: I
authors.lastname: Popa
authors.forename: Jan
authors.initials: J
authors.lastname: Hlavac
mesh_terms: D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D060327:Solid-Phase Synthesis Techniques
chemical_list: C000600481:4-(4'-formyl-3'-methoxyphenoxy)butyric acid; D002087:Butyrates; D006835:Hydrazones