title: Association of endothelial lipase genetic polymorphism with lacunar infarction in a Chinese population.
abstract: BACKGROUND
  This study sought to investigate the correlation between the single nucleotide polymorphism (SNP) rs9958947C>T in the endothelial lipase (LIPG) gene promoter and lacunar infarction in the Han population in China.
  
  
  METHODS
  A case-control method was applied in this study, which included 378 patients with lacunar infarction in the patient group and 404 healthy individuals who received a routine physical examination in the control group. The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods were used to detect the SNP (rs9958947) in the LIPG promoter for the two groups.
  
  
  RESULTS
  The T allele frequency (51.32%) and CT+TT genotype frequency (77.78%) in the patient group were significantly higher than those in the control group (43.32% and 66.34%, respectively). Comparison of the T allele frequency and CT+TT genotype frequency between the two groups showed statistically significant differences. Logistic regression analysis showed that the T allele, male, smoking, hypertension, hyperlipidemia and diabetes were independent risk factors for lacunar infarction in the Han population in China.
  
  
  CONCLUSIONS
  Therefore, we concluded that SNP rs9958947 in the LIPG gene promoter is associated with the incidence of lacunar infarction.
authors.affiliation: Department of Neurology, Chengdu Military General Hospital Chengdu City, 610083, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, First Affiliated Hospital, The Third Military Medical University Chongqing, 400038, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Chengdu Military General Hospital Chengdu City, 610083, China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Wang
authors.affiliation: Department of Neurology, Chengdu Military General Hospital Chengdu City, 610083, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xin Qiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Sai-Yu
authors.initials: SY
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Chengdu Military General Hospital Chengdu City, 610083, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
keywords: Endothelial lipase; lacunar infarction; single nucleotide polymorphism