title: Quantitative assessment of the association between GNB3 C825T polymorphism and cancer risk.
abstract: OBJECTIVE
  The association between GNB3 C825T polymorphism and cancer risk has been investigated. However, results remain inconclusive. In this study we aimed to obtain a more precise estimation of this association.
  
  
  METHODS
  A meta-analysis of 8 eligible studies including 1,812 cancer cases and 3,731 controls was conducted with odds ratios (ORs) and the corresponding 95% confidence interval (95% CI).
  
  
  RESULTS
  The results demonstrated a borderline association between the GNB3 C825T polymorphism and the risk of overall cancer in the dominant model (TT+TC vs CC, OR=1.13, 95% CI=1.00-1.28, PH=0.71, p=0.05). In the stratified analysis by cancer type, significant association of cancer risk was observed in thyroid carcinoma (TC vs CC, OR=1.26, 95% CI=1.02-1.54, PH=0.63, p=0.03; TT+TC vs CC, OR=1.24, 95% CI=1.02-1.51, PH=0.70, p=0.04). After further stratified analysis based on country, the GNB3 C825T polymorphism showed statistically significant association with increased risk of cancer in Austria (TT vs CC, OR=1.44, 95% CI=1.01-2.04, PH-0.88, p-0.04; TT vs TT+TC, OR=1.49, 95% CI=1.07-2.64, PH=0.87, p=0.02) and Germany (TC vs CC, OR=1.25, 95% CI=1.02-1.53; PH=0.87, p=0.03; TT+TC vs CC, OR=1.23, 95% CI=1.02-1.49, PH-0.90, p-0.04).
  
  
  CONCLUSIONS
  The current meta-analysis suggested that the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma.
authors.affiliation: Department of Interventional Radiology & Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Shulong
authors.initials: S
authors.lastname: Zhang
mesh_terms: D001317:Austria; D020022:Genetic Predisposition to Disease; D005858:Germany; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D012306:Risk
chemical_list: C000595803:GNB3 protein, human; D020962:Heterotrimeric GTP-Binding Proteins