title: 18F-sodium fluoride PET/CT in oncology: an atlas of SUVs.
abstract: OBJECTIVE
  The purpose of this study was to analyze the distribution of 18F Sodium Fluoride (18F-NaF) uptake in the normal skeleton, benign and malignant bone lesions, and extraskeletal tissues, using semiquantitative SUV measurements.
  
  
  METHODS
  We retrospectively analyzed data from 129 patients who had 18F-NaF PET/CT at our institution for an oncological diagnosis between 2007 and 2014. There were 99 men and 30 women, 19 to 90 years old (mean [SD], 61.5 [15.5]). The range, average, and SD of SUV were measured for normal bone and extraskeletal tissues uptake for the entire patient population. A separate statistical analysis was performed to compare group A, which corresponds to the population of patient with no 18F-NaF-avid metastatic lesions, and group B, which corresponds to the population of patient with 18F-NaF-avid metastatic lesions. We also measured SUV max and SUV mean for bony metastases and degenerative changes
  
  
  RESULTS
  The PET/CT images were acquired at 30 to 169 minutes (mean [SD], 76.5 [22.8]) after injection of 3.9 to 13.6 mCi (mean [SD], 7.3 [2.4]) of 18F-NaF. The range and mean (SD) of SUV max for 18F-NaF-avid metastasis were 4.5 to 103.3 and 25.9 (16.6) and for 18F-NaF-avid degenerative changes were 3.3 to 52.1 and 16.5 (7.9), respectively.
  
  
  CONCLUSIONS
  Various skeletal sites have different normal SUVs. Skeletal metastases have different SUVs when compared with benign findings such as degenerative changes.
authors.affiliation: From the Divisions of *Nuclear Medicine and †Molecular Imaging, Department of Radiology, Stanford University Medical Center, Stanford, CA.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Sabbah
authors.forename: Tatianie
authors.initials: T
authors.lastname: Jackson
authors.forename: Camila
authors.initials: C
authors.lastname: Mosci
authors.forename: Mehran
authors.initials: M
authors.lastname: Jamali
authors.forename: Ryogo
authors.initials: R
authors.lastname: Minamimoto
authors.forename: Andrew
authors.initials: A
authors.lastname: Quon
authors.forename: Erik S
authors.initials: ES
authors.lastname: Mittra
authors.forename: Andrei
authors.initials: A
authors.lastname: Iagaru
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012969:Sodium Fluoride / Q000493:pharmacokinetics*; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride