title: Patch clamp apply in cardiomyocytes derived from patient's iPS cells for individual anticancer therapy.
abstract: Cardiac side-effects of chemotherapy are old dogs for cancer patient at the beginning of cancer treatment. The deleterious side-effects of chemotherapy on the cardiovascular system have been deemed as a serious clinical issue for a long term, especially sudden cardiac death (SCD) due to QT prolongation. Since induced pluripotent stem cells has been firstly reported by Takahashi and Yamanaka in 2006, iPS has become a valuable research tool. Especially, cardiomyocytes have been successfully derived from human iPS cells which carry on corresponding genetic information of disease, and therefore show a great promise in drug screen on the diseasing model. In this study, we hypothesized that iPS cells created from patient with cancer and carried corresponding genetic alteration will provide a genetic background for sensitivity screening of anticancer drug, as well as side-effects of cardiovascular system.
authors.affiliation: Department of Thoracic Surgery 2, First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China 710061.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery 2, First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China 710061.
authors.forename: Jingkun
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Thoracic Surgery 2, First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China 710061.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Wang
keywords: Patch clamp; iPS cells; individual anticancer therapy