title: Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study.
abstract: Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. In this study, we found that expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). Individuals having higher expression of CTBP1-AS had significantly greater disease risk than those having lower expression. We also identified expression of CTBP1-AS as an independent risk factor for PCOS. A positive correlation was observed between the CTBP1-AS expression and the total T (TT) concentration either unadjusted or after adjusting for age, BMI, and homeostatic model assessment insulin resistance. Taken together, our current study presented the first evidence that the lncRNA CTBP1-AS, a novel AR modulator, is associated with PCOS in Chinese population and established the possibility that abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS.
authors.affiliation: Medical College of Qingdao University, Qingdao, China Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China.
authors.forename: Zhenteng
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China cuifanghao@outlook.com.
authors.forename: Cuifang
authors.initials: C
authors.lastname: Hao
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China.
authors.forename: Dehua
authors.initials: D
authors.lastname: Song
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China.
authors.forename: Hongchu
authors.initials: H
authors.lastname: Bao
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, Yantai, Shandong, China.
authors.forename: Qinglan
authors.initials: Q
authors.lastname: Qu
mesh_terms: D000328:Adult; D000429:Alcohol Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism*; D011944:Receptors, Androgen / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D011944:Receptors, Androgen; D000429:Alcohol Oxidoreductases; C096794:C-terminal binding protein
keywords: CTBP1-AS; androgen receptor; hyperandrogenism; lncRNA; polycystic ovary syndrome