title: Asian women have attenuated sympathetic activation but enhanced renal-adrenal responses during pregnancy compared to Caucasian women.
abstract: Asians have a lower prevalence of hypertensive disorders of pregnancy than Caucasians. Since sympathetic overactivity and dysregulation of the renal-adrenal system (e.g. low aldosterone levels) have been found in preeclamptic women, we hypothesized that Asians have lower muscle sympathetic nerve activity (MSNA) and greater aldosterone concentrations during normal pregnancy than Caucasians. In a prospective study, blood pressure (BP), heart rate (HR), and MSNA were measured during supine and upright tilt (30 deg and 60 deg for 5 min each) in 9 Asians (32 ± 1 years (mean ± SEM)) and 12 Caucasians (29 ± 1 years) during pre-, early (≤8 weeks of gestation) and late (32-36 weeks) pregnancy, and post-partum (6-10 weeks after delivery). Supine MSNA increased with pregnancy in both groups (P < 0.001); it was significantly lower in Asians than Caucasians (14 ± 3 vs. 23 ± 3 bursts min(-1) and 16 ± 5 vs. 30 ± 3 bursts min(-1) in early and late pregnancy, respectively; P = 0.023). BP decreased during early pregnancy (P < 0.001), but was restored during late pregnancy. HR increased during pregnancy (P < 0.001) with no racial difference (P = 0.758). MSNA increased during tilting and it was markedly lower in Asians than Caucasians in late pregnancy (31 ± 6 vs. 49 ± 3 bursts min(-1) at 60 deg tilt; P = 0.003). Upright BP was lower in Asians, even in pre-pregnancy (P = 0.006), and this racial difference persisted during pregnancy. Direct renin and aldosterone increased during pregnancy (both P < 0.001); these hormones were greater in Asians (P = 0.086 and P = 0.014). Thus, Asians have less sympathetic activation but more upregulated renal-adrenal responses than Caucasians during pregnancy. These results may explain, at least in part, why Asian women are at low risk of hypertensive disorders in pregnancy.
authors.affiliation: Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA; University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Okada
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Best
authors.forename: Sara S
authors.initials: SS
authors.lastname: Jarvis
authors.forename: Shigeki
authors.initials: S
authors.lastname: Shibata
authors.forename: Rosemary S
authors.initials: RS
authors.lastname: Parker
authors.forename: Brian M
authors.initials: BM
authors.lastname: Casey
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Levine
authors.forename: Qi
authors.initials: Q
authors.lastname: Fu
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D044466:Asian People; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000208:ethnology*; D007668:Kidney / Q000502:physiology; D011247:Pregnancy / Q000097:blood / Q000208:ethnology / Q000502:physiology*; D012083:Renin / Q000097:blood*; D013564:Sympathetic Nervous System / Q000502:physiology*; D044465:White People
chemical_list: D000450:Aldosterone; D012083:Renin