title: Associated factors of drug-drug interactions of highly active antiretroviral therapy: report from a referral center.
abstract: OBJECTIVE
  To assess different aspects of potential drug-drug interactions (DDIs) including incidence, severity, level of evidence and probable associated factors in Iranian HIV-infected individuals receiving antiretroviral therapy.
  
  
  METHODS
  All adult HIV-infected patients under highly active antiretroviral therapy regimen attending a referral HIV clinic during 1 year were screened retrospectively for potential moderate or severe DDIs by the Lexi-Interact On-Desktop software.
  
  
  RESULTS
  Near seventy percent (69.89%) of detected DDIs in our population were major. The three most common detected potential DDIs were efavirenz + methadone (11 cases), lopinavir-ritonavir + sulfamethoxazole-trimethoprim, (10 cases) and lamivudine + ribavirin (7 cases). Lopinavir-ritonavir (27.96%) and citalopram (23.66%) were the most common offending antiretroviral and non-antiretroviral agents, respectively.
  
  
  CONCLUSIONS
  Performing multicenter and prospective studies is warranted to assess the real clinical as well as economic impacts of DDIs on HIV-infected patients receiving antiretroviral agents in our population and also to develop efficient preventive strategies.
authors.affiliation: International Campus, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Farhoudi
authors.forename: Hossein
authors.initials: H
authors.lastname: Khalili
authors.forename: Iman
authors.initials: I
authors.lastname: Karimzadeh
authors.forename: Ladan
authors.initials: L
authors.lastname: Abbasian
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Iran; drug–drug interactions; highly active antiretroviral therapy; human immunodeficiency virus