title: Treatment of ruptured intracranial aneurysms with the pipeline embolization device.
abstract: BACKGROUND
  The pipeline embolization device (PED) has been used for treatment of unruptured aneurysms. Little is known about the use of the PED in ruptured aneurysms.
  
  
  OBJECTIVE
  To assess the safety and efficacy of the PED in ruptured intracranial aneurysms.
  
  
  METHODS
  This is a case series with prospective data collection on 20 patients with freshly ruptured aneurysms who were treated with PED (with or without adjunctive coiling) at 2 cerebrovascular centers. Patients were loaded with aspirin and clopidogrel or received an infusion of tirofiban intraoperatively.
  
  
  RESULTS
  Hunt and Hess grades were I in 7 patients (35%), II in 9 (45%), and III in 4 (20%). The mean duration from hemorrhage to PED placement was 7±7.0 days. A single device was used in all but 1 patient (95%). The procedure was staged in 20%. There was only 1 complication (5%); this was a fatal intraoperative aneurysm dome rupture that occurred during adjunctive coil deployment. Adjunctive coiling was used in 30%. No patient required an invasive procedure after PED placement. Follow-up angiography (mean, 5.3±4.2 months; range, 2-12 months) showed 100% occlusion in 12 (80%) and incomplete occlusion in 3 patients (20%). At latest follow-up, 19 patients achieved a favorable outcome (modified rankin scale 0-2).
  
  
  CONCLUSIONS
  In our preliminary experience, treatment of ruptured aneurysms with the PED was associated with low complication rates, high occlusion rates, and favorable outcomes. These findings suggest that PED may be a safe and effective option for patients with favorable Hunt and Hess grades and aneurysms difficult to treat with conventional methods.
authors.affiliation: *Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania; ‡Department of Neurosurgery, University of Iowa, Iowa City, Iowa.
authors.forename: Nohra
authors.initials: N
authors.lastname: Chalouhi
authors.forename: Mario
authors.initials: M
authors.lastname: Zanaty
authors.forename: Alex
authors.initials: A
authors.lastname: Whiting
authors.forename: Stavropoula
authors.initials: S
authors.lastname: Tjoumakaris
authors.forename: David
authors.initials: D
authors.lastname: Hasan
authors.forename: Norman
authors.initials: N
authors.lastname: Ajiboye
authors.forename: Shannon
authors.initials: S
authors.lastname: Hann
authors.forename: Robert H
authors.initials: RH
authors.lastname: Rosenwasser
authors.forename: Pascal
authors.initials: P
authors.lastname: Jabbour
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000601:surgery*; D001241:Aspirin; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D001241:Aspirin