title: Quantification of myocardial blood flow with dynamic perfusion 3.0 Tesla MRI: Validation with (15) O-water PET.
abstract: BACKGROUND
  To develop and validate a method for quantifying myocardial blood flow (MBF) using dynamic perfusion magnetic resonance imaging (MBFMRI ) at 3.0 Tesla (T) and compare the findings with those of (15) O-water positron emission tomography (MBFPET ).
  
  
  METHODS
  Twenty healthy male volunteers underwent magnetic resonance imaging (MRI) and (15) O-water positron emission tomography (PET) at rest and during adenosine triphosphate infusion. The single-tissue compartment model was used to estimate the inflow rate constant (K1). We estimated the extraction fraction of Gd-DTPA using K1 and MBF values obtained from (15) O-water PET for the first 10 subjects. For validation, we calculated MBFMRI values for the remaining 10 subjects and compared them with the MBFPET values. In addition, we compared MBFMRI values of 10 patients with coronary artery disease with those of healthy subjects.
  
  
  RESULTS
  The mean resting and stress MBFMRI values were 0.76 ± 0.10 and 3.04 ± 0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBFPET values (r = 0.96, P < 0.01). The mean stress MBFMRI value was significantly lower for the patients (1.92 ± 0.37) than for the healthy subjects (P < 0.001).
  
  
  CONCLUSIONS
  The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease.
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Tomiyama
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Manabe
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Oyama-Manabe
authors.affiliation: Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Masanao
authors.initials: M
authors.lastname: Naya
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugimori
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirata
authors.affiliation: Faculty of Health Sciences, Hokkaido University Graduate School of Health Sciences, Sapporo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
authors.affiliation: Faculty of Health Sciences, Hokkaido University Graduate School of Health Sciences, Sapporo, Japan.
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000473:pathology; D003326:Coronary Circulation / Q000502:physiology*; D019786:Gadolinium DTPA / Q000737:chemistry; D064368:Healthy Volunteers; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D015588:Observer Variation; D010104:Oxygen Radioisotopes / Q000737:chemistry; D010477:Perfusion; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D014867:Water; D055815:Young Adult
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water; D019786:Gadolinium DTPA
keywords: 15O-water positron emission tomography; dynamic magnetic resonance imaging; myocardial blood flow; perfusion