title: Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD.
abstract: OBJECTIVE
  To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls.
  
  
  METHODS
  The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured.
  
  
  RESULTS
  Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the controls. The total oxidant value, body fat percentage, and waist/hip ratio were higher in patients with COPD than in the healthy controls. There was a moderately negative correlation between the total oxidant value and the maximal aerobic capacity, while there was a moderately positive correlation between the total antioxidant values and maximal aerobic capacity in patients with COPD.
  
  
  CONCLUSIONS
  Low aerobic capacity, increased oxidative stress, and adiposity are related to impaired pulmonary functions in patients with mild to moderate COPD and might have a role in the pathogenesis of COPD.
authors.affiliation: Department of Physiology, Afyon Kocatepe University, Afyonkarahisar, Turkey. dragenc@hotmail.com
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Genç
authors.forename: Kağan
authors.initials: K
authors.lastname: Üçok
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Şener
authors.forename: Tülay
authors.initials: T
authors.lastname: Koyuncu
authors.forename: Olcay
authors.initials: O
authors.lastname: Akar
authors.forename: Sefa
authors.initials: S
authors.lastname: Çelik
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ünlü
mesh_terms: D050154:Adiposity / Q000502:physiology; D001823:Body Composition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012129:Respiratory Function Tests