title: Metabolic regulation and energy homeostasis through the primary Cilium.
abstract: Obesity and diabetes represent a significant healthcare concern. In contrast to genome-wide association studies that, some exceptions notwithstanding, have offered modest clues about pathomechanism, the dissection of rare disorders in which obesity represents a core feature have highlighted key molecules and structures critical to energy regulation. Here we focus on the primary cilium, an organelle whose roles in energy homeostasis have been underscored by the high incidence of obesity and type II diabetes in patients and mouse mutants with compromised ciliary function. We discuss recent evidence linking ciliary dysfunction to metabolic defects and we explore the contribution of neuronal and nonneuronal cilia to these phenotypes.
authors.affiliation: Center for Human Disease Modeling, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: edwin.oh@dm.duke.edu.
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Oh
authors.affiliation: Center for Human Disease Modeling, Duke University School of Medicine, Durham, NC 27710, USA.
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Vasanth
authors.affiliation: Center for Human Disease Modeling, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: nicholas.katsanis@dm.duke.edu.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Katsanis
mesh_terms: D000818:Animals; D002923:Cilia / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism; D007031:Hypothalamus / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D054411:Receptors, Leptin / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism
chemical_list: D020738:Leptin; D008869:Microtubule-Associated Proteins; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor