title: Polycyclic aromatic hydrocarbon residues in serum samples of autopsied individuals from Tennessee.
abstract: This study reports the concentrations of polycyclic aromatic hydrocarbons (PAHs) in human blood sera samples (n = 650) obtained at autopsy from individuals who died of drug abuse, alcohol toxicity, homicide, suicide and other unknown causes. The analyzed samples from decedents revealed the presence of PAHs of which B(a)P was the most predominant one, followed by benzo(b)fluoranthene and benzo(k)fluoranthene. The other PAHs detected sporadically and measured were benzo(g,h,i)perylene, acenaphthene, anthracene, phenanthrene, and fluoranthene The mean concentrations of PAHs were greater in the twenties to fifties age groups compared to others. The PAH residue levels detected were high in African Americans compared to Caucasians, Asians, and Hispanics. It appears that environmental exposure, dietary intake and in some cases occupational exposure may have contributed to the PAH body burden. While the PAH residue concentrations measured fall within the range of those reported for healthy adults elsewhere, in isolated cases, the concentrations detected were high, calling the need for a reduction in PAH emissions and human biomonitoring studies for purposes of risk assessment.
authors.affiliation: Department of Biochemistry & Cancer Biology, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208, USA. aramesh@mmc.edu.
authors.forename: Aramandla
authors.initials: A
authors.lastname: Ramesh
authors.affiliation: Department of Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208, USA. akumar@mmc.edu.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: King Magnet High School, 613 17th Ave North, Nashville, TN 37203, USA. mounikaaramandla26@gmail.com.
authors.forename: Mounika P
authors.initials: MP
authors.lastname: Aramandla
authors.affiliation: Department of Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208, USA. anyanda@mmc.edu.
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Nyanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D002648:Child; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000097:blood*; D005006:Ethnicity; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood*; D015995:Prevalence; D013714:Tennessee
chemical_list: D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons