title: Association of EGF rs4444903 and XPD rs13181 polymorphisms with cutaneous melanoma in Caucasians.
abstract: Cutaneous melanoma (CM) is a malignant skin cancer with the high incidence in whiteskinned populations. Host genetic factors (such as: genes in nucleotide excision repair system or cell proliferation regulation system) interacted with ultraviolet radiation are potential reasons for CM. Previous studies about associations between CM and the rs4444903 (+61A>G) in the Epidermal growth factor gene (EGF) or rs13181 (+35931 A>C) in the xeroderma pigmentosum group D gene (XPD) have produced inconsistent results. To clarify these associations, metaanalyses of available candidate case-control association studies about Caucasians were performed. Data of each study were gathered according to the "Quality-Evaluation Score" (Ver.1.0). Finally, the meta-analysis with 2167 cases/4211 controls showed that the EGF rs4444903 had no significant association with CM (p>0.05), while the analysis with 3,492 cases/5,381 controls indicated the A allele of XPD rs13181 was significantly associated with CM (odds ratio= 0.93, 95% CI: 0.87-0.99; p=0.019). These results are also supported with linkage disequilibrium (LD) structure analysis. The current meta-analyses results suggest that the XPD gene, but not the EGF gene, has contributed to CM susceptibility, and XPD is a possible drug target.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Jia
authors.initials: J
authors.lastname: Song
authors.forename: Mei-Yan
authors.initials: MY
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University; 55 Guangyuan Xi Road, Shanghai 200240, China.. lcai@gordonlifescience.org.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Gordon Life Science Institute, Boston, MA 02478, USA.. helinhelinhelin3@gmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Chou
mesh_terms: D004815:Epidermal Growth Factor / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics*; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004815:Epidermal Growth Factor; D051759:Xeroderma Pigmentosum Group D Protein