title: Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain.
abstract: In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V(T)) by CS-IF and ICA-IF were compared to the reference V(T) obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V(T) values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r² = 0.91 (p<0.05), and r² = 0.71 (p<0.05) using CS-IF.
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
authors.forename: Rostom
authors.initials: R
authors.lastname: Mabrouk
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Rusjan
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Romina
authors.initials: R
authors.lastname: Mizrahi
authors.affiliation: Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Jacobs
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Koshimori
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Houle
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Ko
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Strafella
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D007700:Kinetics; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D049268:Positron-Emission Tomography / Q000379:methods*; D025341:Principal Component Analysis; D018079:Receptors, GABA / Q000235:genetics / Q000378:metabolism*; D012984:Software
chemical_list: D018079:Receptors, GABA; C499229:TSPO protein, human