title: Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?
abstract: Hyaluronic acid (HA) injections are used to treat osteoarthritis of the hip but their efficacy has not been clearly established. The purpose of this meta-analysis was to determine the effect of HA injections on hip pain. There were twenty-three studies that met our criteria and the mean decrease in visual analog scores (VAS) was -1.97 (95% CL, 2.83 to -1.12, P<0.0001). However, the clinical relevance of this change is difficult to determine since the decrease in VAS was only -0.27 in the six randomized trials in the study and the duration of follow-up in most studies was less than six months. Multicenter randomized trials are needed to determine the true efficacy of HA injections in decreasing pain associated with hip osteoarthritis.
authors.affiliation: Department of Orthopaedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.
authors.forename: Jay R
authors.initials: JR
authors.lastname: Lieberman
authors.affiliation: Vanderbilt Orthopaedic Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Engstrom
authors.affiliation: University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut.
authors.forename: Olga
authors.initials: O
authors.lastname: Solovyova
authors.affiliation: Biostatistics Center, Connecticut Institute for Clinical and Translational Science University of Connecticut Health Center, Farmington, Connecticut.
authors.forename: Carol
authors.initials: C
authors.lastname: Au
authors.affiliation: Connecticut Institute for Clinical and Translational Science, University of Connecticut Health Center, Farmington, Connecticut.
authors.forename: James J
authors.initials: JJ
authors.lastname: Grady
mesh_terms: D006621:Hip Joint; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D015207:Osteoarthritis, Hip / Q000188:drug therapy*; D016896:Treatment Outcome; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: Synvisc; hip; hyaluronic acid; injection; osteoarthritis