title: Pseudomonas aeruginosa adaptation to human hosts.
abstract: Bacterial whole-genome sequencing of longitudinally collected isolates enables the investigation of evolutionary trajectories, which may inform both the prevention and treatment of human-associated pathogen infections. A new study explores the adaptation of multiple lineages of Pseudomonas aeruginosa to the lungs of young patients with cystic fibrosis and finds evidence of convergent molecular evolution and historical contingencies.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Snitkin
authors.affiliation: National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Segre
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D002353:Carrier State / Q000382:microbiology*; D003550:Cystic Fibrosis / Q000382:microbiology*; D019143:Evolution, Molecular; D005260:Female; D005798:Genes, Bacterial; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D012137:Respiratory System / Q000382:microbiology*