title: Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women.
abstract: After giving birth, women typically experience decreased sexual desire and increased responsiveness to infant stimuli. These postpartum changes may be viewed as a trade-off in reproductive interests, which could be due to alterations in brain activity including areas associated with reward. The goal of this study was to describe the roles of oxytocin and parity on reward area activation in response to reproductive stimuli, specifically infant and sexual images. Because they have been shown to be associated with reward, the ventral tegmental area (VTA) and nucleus accumbens (NAc) were targeted as areas of expected alterations in activity. Oxytocin was chosen as a potential mediator of reproductive trade-offs because of its relationship to both mother-infant interactions, including breastfeeding and bonding, and sexual responses. We predicted that postpartum women would show higher reward area activation to infant stimuli and nulliparous women would show higher activation to sexual stimuli and that oxytocin would increase activation to infant stimuli in nulliparous women. To test this, we measured VTA and NAc activation using fMRI in response to infant photos, sexual photos, and neutral photos in 29 postpartum and 30 nulliparous women. Participants completed the Sexual Inhibition (SIS) and Sexual Excitation (SES) Scales and the Brief Index of Sexual Function for Women (BISF-W), which includes a sexual desire dimension, and received either oxytocin or placebo nasal spray before viewing crying and smiling infant and sexual images in an fMRI scanner. For both groups of women, intranasal oxytocin administration increased VTA activation to both crying infant and sexual images but not to smiling infant images. We found that postpartum women showed lower SES, higher SIS, and lower sexual desire compared to nulliparous women. Across parity groups, SES scores were correlated with VTA activation and subjective arousal ratings to sexual images. In postpartum women, sexual desire was positively correlated with VTA activation to sexual images and with SES. Our findings show that postpartum decreases in sexual desire may in part be mediated by VTA activation, and oxytocin increased activation of the VTA but not NAc in response to sexual and infant stimuli. Oxytocin may contribute to the altered reproductive priorities in postpartum women by increasing VTA activation to salient infant stimuli.
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA; The Kinsey Institute for Research in Sex, Gender, and Reproduction, Indiana University, Morrison 313, 1165 E. Third St., Bloomington, IN 47405, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gregory
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA.
authors.forename: Hu
authors.initials: H
authors.lastname: Cheng
authors.affiliation: The Kinsey Institute for Research in Sex, Gender, and Reproduction, Indiana University, Morrison 313, 1165 E. Third St., Bloomington, IN 47405, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Rupp
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA.
authors.forename: Dale R
authors.initials: DR
authors.lastname: Sengelaub
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USA; The Kinsey Institute for Research in Sex, Gender, and Reproduction, Indiana University, Morrison 313, 1165 E. Third St., Bloomington, IN 47405, USA. Electronic address: jheiman@indiana.edu.
authors.forename: Julia R
authors.initials: JR
authors.lastname: Heiman
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D007223:Infant; D007989:Libido / Q000187:drug effects*; D008279:Magnetic Resonance Imaging; D009034:Mother-Child Relations / Q000523:psychology; D009714:Nucleus Accumbens / Q000187:drug effects; D009769:Object Attachment; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D010298:Parity; D010775:Photic Stimulation; D049590:Postpartum Period / Q000523:psychology; D011247:Pregnancy; D012201:Reward; D012725:Sexual Behavior / Q000187:drug effects*; D017557:Ventral Tegmental Area / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010121:Oxytocin
keywords: Nucleus accumbens; Oxytocin; Postpartum; Reward; Sexual and infant stimuli; Ventral tegmental area