title: Are animal models useful or confusing in understanding the human feto-maternal relationship? A debate.
abstract: The proposition "This house agrees that the proper study of man is woman" was debated. For those negating the proposition, the alternative was that "animal models are useful in understanding the human feto-maternal relationship." Evidence for the proposition emphasized molecular and structural differences between the human and animal placenta and placentation. Evidence against the proposition and in favor of the alternative focused on functional and structural homologies, emphasizing that different molecules could be used in humans to achieve similar functional effects seen in animal (e.g., mouse) models. It was agreed that one always needed to test the validity of animal data by studying humans. The advantages and limitations of animal models were discussed.
authors.affiliation: INSERM UMRS-976, Hôpital Saint Louis, Paris, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Chaouat
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: clarkd@mcmaster.ca.
authors.forename: David A
authors.initials: DA
authors.lastname: Clark
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology*; D000818:Animals; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D023421:Models, Animal; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D013045:Species Specificity
chemical_list: D006680:HLA Antigens
keywords: Animal models; Pregnancy immunology