title: Inulin-D-α-tocopherol succinate (INVITE) nanomicelles as a platform for effective intravenous administration of curcumin.
abstract: The aim of this work was to evaluate the potential of INVITE-based nanomicelles, an amphiphilic polymer constituted by inulin (INU) and vitamin E (VITE), as a platform for improving the biopharmaceutical properties of hydrophobic drugs. For this purpose, curcumin was selected as a model and curcumin-INVITE nanomicelles were prepared. This drug delivery system was characterized both in vitro for what concerns the physicochemical properties, blood compatibility, and cellular uptake, and in vivo for the evaluation of the pharmacokinetic profile. It was found that these nanomicelles released curcumin in a controlled manner, and they were able to penetrate cellular membrane. Moreover, they showed an improved pharmacokinetic profile after intravenous administration. In conclusion, INVITE micelles might constitute promising nanocarriers for improving the biopharmaceutical performance of hydrophobic drugs.
authors.affiliation: Department of Drug Sciences, University of Pavia , Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tripodo
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Pasut
authors.forename: Adriana
authors.initials: A
authors.lastname: Trapani
authors.forename: Anna
authors.initials: A
authors.lastname: Mero
authors.forename: Francesco Massimo
authors.initials: FM
authors.lastname: Lasorsa
authors.forename: Theodora
authors.initials: T
authors.lastname: Chlapanidas
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trapani
authors.forename: Delia
authors.initials: D
authors.lastname: Mandracchia
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D003474:Curcumin / Q000008:administration & dosage* / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D007444:Inulin / Q000008:administration & dosage* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D008823:Micelles; D007444:Inulin; D024502:alpha-Tocopherol; D003474:Curcumin