title: The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases.
abstract: OBJECTIVE
  To analyse the clinical features, laboratory data, foetal-maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS).
  
  
  METHODS
  The European Registry on APS became a Registry within the framework of the European Forum on Antiphospholipid Antibody projects and placed on a website in June 2010. Cases with obstetric complaints related to aPL who tested positive for aPL prospectively and retrospectively were included. The three-year survey results are reported.
  
  
  RESULTS
  338 women with 1253 pregnancy episodes were included; 915 were historical and 338 were latest episodes. All these women tested positive for aPL. 247 of the 338 fulfilled the Sydney criteria. According to the laboratory categories, 84/247 were in category I, 42 in IIa, 66 in IIb and 55 in IIc. Obstetric complications other than foetal losses, appeared in 129 cases (52.2%). 192 (77.7%) had a live birth and 55 (22.3%) did not. The latter group of only 38 cases (69%) received adequate treatment and 17 (31%) did not. 177/247 (72%) women were put on heparin plus LDA. Thrombosis appeared in two during pregnancy and in 14 during the puerperium. 7 (3%) women evolved to complete SLE.
  
  
  CONCLUSIONS
  OAPS shows differential characteristics than classical APS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. OAPS has very good foetal-maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms.
authors.affiliation: Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital; Department of Medicine, Universitat Autonòma, Barcelona, Spain. Electronic address: jalijotas@vhebron.net.
authors.forename: Jaume
authors.initials: J
authors.lastname: Alijotas-Reig
authors.affiliation: Obstetric and Gynaecolgy Department, Vall d'Hebron University Hospital, Universitat Autonòma, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Ferrer-Oliveras
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine Azienda Ospedaliera, University of Padua, Padua, Italy.
authors.forename: Amelia
authors.initials: A
authors.lastname: Ruffatti
authors.affiliation: Rheumatology and Clinical Immunology Unit, Ospedale Civile, Brescia, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Tincani
authors.affiliation: Haematoly Unit, Hippokrateion Hospital of Thessaloniki, Greece.
authors.forename: Elmina
authors.initials: E
authors.lastname: Lefkou
authors.affiliation: Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
authors.forename: Ma Tiziana
authors.initials: MT
authors.lastname: Bertero
authors.affiliation: Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Coloma-Bazan
authors.affiliation: Department of Gynaecology, Gemmeli Hospital, Catholic University, Roma, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: de Carolis
authors.affiliation: Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Espinosa
authors.affiliation: Vita-Salute Sant Raffaele University and IRCCS Ospedale San raffaele, Milano, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rovere-Querini
authors.affiliation: Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Kuzenko
authors.affiliation: Internal Medicine Department, Althaia Healthcare Network of Manresa, Barcelona, Spain.
authors.forename: Enrique E
authors.initials: EE
authors.lastname: Valverde
authors.affiliation: Internal Medicine Department, Hospital Universitario La Paz, Universidad Autònoma, Madrid, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Robles
authors.affiliation: Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Ricard
authors.initials: R
authors.lastname: Cervera
authors.affiliation: Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Canti
authors.affiliation: Rheumatology and Clinical Immunology Unit, Ospedale Civile, Brescia, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: Fredi
authors.affiliation: Internal Medicine Department, Hospital Universitario La Paz, Universidad Autònoma, Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gil-Aguado
authors.affiliation: Current workplace: Department of Pediatrics, Turku University Hospital, Turku, Finland.
authors.forename: Krista
authors.initials: K
authors.lastname: Lundelin
authors.affiliation: Obstetric and Gynaecolgy Department, Vall d'Hebron University Hospital, Universitat Autonòma, Barcelona, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Llurba
authors.affiliation: Obstetric and Gynaecolgy Department, Vall d'Hebron University Hospital, Universitat Autonòma, Barcelona, Spain.
authors.forename: Taisiya
authors.initials: T
authors.lastname: Melnychuk
authors.affiliation: Rheumatology and Clinical Immunology Unit, Ospedale Civile, Brescia, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Nalli
authors.affiliation: Department of Obstetrics and Gynaecology, University of Turin, Turin, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Picardo
authors.affiliation: Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Silvestro
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine Azienda Ospedaliera, University of Padua, Padua, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: del Ross
authors.affiliation: Obstetric and Gynaecolgy Department, Vall d'Hebron University Hospital, Universitat Autonòma, Barcelona, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Farran-Codina
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D012042:Registries; D012307:Risk Factors
chemical_list: D017152:Antibodies, Antiphospholipid
keywords: Antiphospholipid antibody; Laboratory categories; Obstetric antiphospholipid syndrome; Obstetric morbidity; Registry; Treatment