title: Comparison of voice outcome after vocal fold augmentation with fat or calcium hydroxylapatite.
abstract: OBJECTIVE
  To evaluate the short-term voice outcomes of vocal fold augmentation using fat compared to calcium hydroxylapatite product Radiesse Voice (Merz Aesthetics).
  
  
  METHODS
  Retrospective study design.
  
  
  METHODS
  Sixty-six consecutive patients with vocal fold insufficiency were recruited, including the final 33 patients treated with fat and all 33 patients treated with calcium hydroxylapatite product. Before April 2011, fat augmentation was the standard treatment; from April 2011, only calcium hydroxylapatite product was used. For all subjects, videolaryngostroboscopic evaluation, s/z ratios, and voice handicap index (VHI) were analyzed.
  
  
  METHODS
  Treatment outcomes were evaluated 3 months after the augmentation. Two patients augmented with fat (both after 6 months), versus four augmented with calcium hydroxylapatite product (mean after 7 months), needed reintervention. Mean VHI decreased from 18 points in the fat augmentation group compared to 17 points in the calcium hydroxylapatite group. Mean s/z ratio changed -0.33 in the fat augmentation group compared to -0.46 in the calcium hydroxylapatite group.
  
  
  CONCLUSIONS
  This retrospective cohort demonstrates that there are no short-term differences in VHI outcome or number of reinterventions for augmentation with fat compared to calcium hydroxylapatite product Radiesse Voice (Merz Aesthetics).
  
  
  METHODS
  Level 4.
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Wouter L
authors.initials: WL
authors.lastname: Lodder
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D001672:Biocompatible Materials / Q000008:administration & dosage; D017886:Durapatite / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D007828:Laryngoscopy; D008297:Male; D019736:Prostheses and Implants; D012189:Retrospective Studies; D049489:Stroboscopy; D013997:Time Factors; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D014827:Vocal Cords / Q000503:physiopathology / Q000601:surgery*; D014833:Voice Quality / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite
keywords: Glottal insufficiency; calcium hydroxylapatite; fat augmentation; outcome; voice handicap index