title: Highly sensitive and selective detection of miRNA: DNase I-assisted target recycling using DNA probes protected by polydopamine nanospheres.
abstract: Based on the protective properties of polydopamine nanospheres for DNA probes against nuclease digestion, we have developed a DNase I-assisted target recycling signal amplification method for highly sensitive and selective detection of miRNA.
authors.affiliation: MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, and Department of Chemistry, College of Chemistry & Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China. cyyang@xmu.edu.cn ljzhou@xmu.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lin
authors.forename: Yishun
authors.initials: Y
authors.lastname: Huang
authors.forename: Rujun
authors.initials: R
authors.lastname: Pan
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.forename: Leiji
authors.initials: L
authors.lastname: Zhou
authors.forename: Chaoyong James
authors.initials: CJ
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D015342:DNA Probes / Q000737:chemistry* / Q000235:genetics; D003850:Deoxyribonuclease I / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D057230:Limit of Detection; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D054118:Nanospheres / Q000737:chemistry*; D021141:Nucleic Acid Amplification Techniques; D009690:Nucleic Acid Conformation; D011108:Polymers / Q000737:chemistry*
chemical_list: D015342:DNA Probes; D004337:Drug Carriers; D007211:Indoles; D035683:MicroRNAs; D011108:Polymers; C568283:polydopamine; D003850:Deoxyribonuclease I