title: Trends in human papillomavirus-related oropharyngeal cancer in Israel.
abstract: The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel.
  
  
  
  The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry.
  
  
  
  Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p < .02).
  
  
  
  This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel. © 2015 Wiley Periodicals, Inc. Head Neck 38: E274-E278, 2016.
authors.affiliation: Department of Otolaryngology, Rambam Medical Center, The Technion, Israel Institute of Technology, Haifa, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Amit
authors.affiliation: Department of Pathology, Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Kaplan
authors.initials: K
authors.lastname: Ilana
authors.affiliation: Department of Oncology, Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Sharon Pelles
authors.initials: SP
authors.lastname: Avraham
authors.affiliation: Department of Otolaryngology, Rambam Medical Center, The Technion, Israel Institute of Technology, Haifa, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Binenbaum
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Israel.
authors.forename: Gideon
authors.initials: G
authors.lastname: Bachar
authors.affiliation: Oncological Institute, Rambam Medical Center, Haifa, Israel.
authors.forename: Salem
authors.initials: S
authors.lastname: Billan
authors.affiliation: Department of Otolaryngology, The French Hospital, Israel.
authors.forename: Suliman
authors.initials: S
authors.lastname: Zaarura
authors.affiliation: Department of Oral Medicine, The Hebrew University-Hadassah School of Dental Medicine, Israel.
authors.forename: Rakefet
authors.initials: R
authors.lastname: Czerninski
authors.affiliation: Department of Oral Medicine, The Hebrew University-Hadassah School of Dental Medicine, Israel.
authors.forename: Matan
authors.initials: M
authors.lastname: Bar-Tov
authors.affiliation: Department of Oral Medicine, The Hebrew University-Hadassah School of Dental Medicine, Israel.
authors.forename: Alexander
authors.initials: A
authors.lastname: Maly
authors.affiliation: Department Pathology, The Technion, Israel Institute of Technology, Haifa, Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Akrish
authors.affiliation: Department of Otolaryngology, Rambam Medical Center, The Technion, Israel Institute of Technology, Haifa, Israel.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Gil
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
keywords: head and neck; human papillomavirus; oropharynx or oropharyngeal carcinoma; prevalence