title: Spirituality and the recovery of quality of life following hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  Spirituality has been linked to improved adjustment and functioning in individuals with cancer; however, its effect on quality of life following hematopoietic stem cell transplantation (HSCT) has not been well-studied. This study investigated changes in spirituality in hematologic cancer patients recovering from HSCT and relationships between spirituality and dimensions of quality of life following HSCT.
  
  
  METHODS
  Participants (N = 220) completed measures of two dimensions of spirituality (meaning/peace and religious faith), depression, anxiety, fatigue, pain, and physical and functional well-being prior to transplant and at 1-, 3-, 6-, and 12-months posttransplant.
  
  
  RESULTS
  Meaning/peace declined at 1-month posttransplant and returned to pretransplant levels by 6-months posttransplant, and faith increased from pretransplant to 6-months posttransplant. Mixed-effects linear regression models indicated that greater pretransplant meaning/peace, but not religious faith, predicted less depression, anxiety, and fatigue, and better physical and functional well-being during the 12-months following transplant.
  
  
  CONCLUSIONS
  The capacity to find meaning and peace may facilitate recovery following HSCT. Results suggest that spirituality may be a resilience factor that could be targeted to improve quality of life for HSCT recipients.
authors.affiliation: Department of Psychiatry, University of Wisconsin- Madison.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Leeson
authors.affiliation: Department of Psychology, University of South Florida.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Nelson
authors.affiliation: Carbone Cancer Center, University of Wisconsin-Madison and.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rathouz
authors.affiliation: Carbone Cancer Center, University of Wisconsin-Madison and.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Juckett
authors.affiliation: Department of Psychology, University of Wisconsin- Madison.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Coe
authors.affiliation: Carbone Cancer Center, University of Wisconsin-Madison.
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Caes
authors.affiliation: Department of Psychiatry, University of Wisconsin- Madison.
authors.forename: Erin S
authors.initials: ES
authors.lastname: Costanzo
mesh_terms: D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D029181:Spirituality; D019172:Transplantation Conditioning / Q000523:psychology*