title: Asymmetric intermolecular cobalt-catalyzed Pauson-Khand reaction using a P-stereogenic bis-phosphane.
abstract: The asymmetric intermolecular and catalytic Pauson-Khand reaction has remained an elusive goal since Khand and Pauson discovered this transformation. Using a novel family of P-stereogenic phosphanes, we developed the first catalytic system with useful levels of enantioselection for the reaction of norbornadiene and trimethylsilylacetylene. The results demonstrate that Co-bisphosphane systems are sufficiently reactive and that they lead to high selectivity in the intermolecular process.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona) , Baldiri Reixac 10, 08028 Barcelona, Spain.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Orgué
authors.forename: Thierry
authors.initials: T
authors.lastname: León
authors.forename: Antoni
authors.initials: A
authors.lastname: Riera
authors.forename: Xavier
authors.initials: X
authors.lastname: Verdaguer
mesh_terms: D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009636:Norbornanes / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D001880:Boranes; D009636:Norbornanes; D010720:Phosphines; D014297:Trimethylsilyl Compounds; D003035:Cobalt; C044646:phosphine