title: Regioselective gold-catalyzed oxidative C-N bond formation.
abstract: A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.
authors.affiliation: Department of Chemistry, University of Rhode Island , 51 Lower College Road, Kingston, Rhode Island 02881, United States.
authors.forename: Louis
authors.initials: L
authors.lastname: Marchetti
authors.forename: Abhishek
authors.initials: A
authors.lastname: Kantak
authors.forename: Riley
authors.initials: R
authors.lastname: Davis
authors.forename: Brenton
authors.initials: B
authors.lastname: DeBoef
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000814:Aniline Compounds; D009942:Organometallic Compounds; D006046:Gold; C023650:aniline