title: [Impact analysis of shenqi fuzheng injection of course on liver function based on hospital information system data].
abstract: OBJECTIVE
  Use propensity score methods to explore the effect of Shenqi Fuzheng injection (SQFZ) on ALT and AST lever of real worlds.
  
  
  METHODS
  HIS data from 18 hospitals was analyzed. Patients ranging from 18 to 80 years, it were divided into the cases group was used Shenqi Fuzheng injection > 21 days under the instruction, and control group used SQFZ ≤ 21 days. A large number of confounding biases are taken into account through the generalized boosted models (GBM) and multiple logistic regression model to estimate the treatment effects of SQFZ on abnormal changes in ALT and AST index and to explore possible influencing factors.
  
  
  RESULTS
  Sventy and one confounding factors had been counterpoised, stratified analysis showed that the abnormal changes of cases group lower than control group, but not statistically significant.
  
  
  CONCLUSIONS
  Analysis of HIS database showed that significant effects of SQFZ on abnormal changes in ALT and AST have not been found. The results of this study form the retrospective data, for the purpose of validating its clinical safety should be have a prospective clinical study of large sample.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Ai
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Xie
authors.forename: Li
authors.initials: L
authors.lastname: You
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006751:Hospital Information Systems; D006801:Humans; D007267:Injections; D008099:Liver; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng