title: [Comparison of tumefactive demyelinating lesions and glioma by clinical presentations and neuroimaging studies].
abstract: OBJECTIVE
  To explore the clinical and imaging features of tumefactive demyelinating lesions (TDL) and glioma.
  
  
  METHODS
  The brain computed tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ((1)H-MRS) features of 60 pathologically confirmed TDL patients and 65 glioma ones, hospitalized at Navy General Hospital from 2005 to 2013, were reviewed and analyzed.
  
  
  RESULTS
  The mean onset age of glioma was significantly older than that of TDL. The onset symptom was headache for TDL and headache and epilepsy for glioma. The features of lesions on brain CT scan: no hyperdensity in TDL group and 39 with hyperdense lesions in glioma group. Tissue necrosis was more frequently found in lesions of glioma than TDL, especially for higher grade glioma. And increased β and γ-Glx on (1)H-MRS was most frequently found in TDL.
  
  
  CONCLUSIONS
  The onset age of glioma is older than TDL. The headache is the top onset symptoms of TDL and epiplesy occurs frequently only in glioma. The hyperdense lesions on CT scan support more the diagnosis of glioma. The lesions with tissue necrosis may be a diagnostic clue for high grade glioma. On (1)H-MRS, increased β and γ-Glx are most frequently found in TDL. Dynamic observation of imaging changes may be more important for facilitating the diagnosis of TDL, especially in conjunctions with imaging characteristics and clinical features.
authors.affiliation: Department of Neurology, Navy Clinical College, Second Military Medical University, Beijing 100048, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Liu
authors.forename: Wenying
authors.initials: W
authors.lastname: Qiao
authors.forename: Kuihong
authors.initials: K
authors.lastname: Zheng
authors.forename: Hulin
authors.initials: H
authors.lastname: Zhao
authors.forename: Hairong
authors.initials: H
authors.lastname: Qian
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
authors.forename: Feng
authors.initials: F
authors.lastname: Duan
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.affiliation: Department of Neurology, Navy General Hospital, Beijing 100048, China. Email: bjqxk@sina.com.
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Qi
mesh_terms: D017668:Age of Onset; D003711:Demyelinating Diseases; D005910:Glioma; D006801:Humans; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D059906:Neuroimaging