title: Is the level of maternal serum prohepcidin associated with preeclampsia?
abstract: OBJECTIVE
  The objective of the study was to compare pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), C-reactive protein (CRP), IL-6 and iron status parameters in preeclamptic (PE) and healthy pregnant women, and to examine the relationship between serum pro-hepcidin levels and iron parameters of preeclampsia (PE).
  
  
  METHODS
  In a prospective controlled study, we collected serum from women with normal pregnancy (n = 37) and from women with PE (n = 30) at the Department of Obstetrics and Gynecology at Turgut Ozal University between February 2010 and January 2013. Pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), CRP, IL-6 and iron status parameters were measured in all patients and compared between groups.
  
  
  RESULTS
  Levels of serum prohepcidin in PE and control groups were similar and amount 69.4 ± 19.7 and 71.9 ± 22.1 ng/ml, respectively. The difference was not statistically significant (p: 0.694). On the other hand, the study group had a statistically lower iron binding capacity (IBC), total iron binding capacity, transferin, total protein, albumin levels (p < 0.05). No significant differences were found among prohepcidin, Hb concentration, Hct, iron, ferritin, IL-6, urea and creatine in both the groups.
  
  
  CONCLUSIONS
  In pregnancies complicated by PE with normal values of hemoglobin and hematocrit, serum prohepcidin concentrations are similar to those observed in healthy pregnant women. The analysis revealed no significant correlations between prohepcidin level and serum iron, serum ferritin or transferrin in the PE.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal University , Ankara , Turkey .
authors.forename: Candan Iltemir
authors.initials: CI
authors.lastname: Duvan
authors.forename: Serap
authors.initials: S
authors.lastname: Simavli
authors.forename: Esra Aktepe
authors.initials: EA
authors.lastname: Keskin
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Onaran
authors.forename: Nilgun Ozturk
authors.initials: NO
authors.lastname: Turhan
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: C578702:HAMP protein, human; D006454:Hemoglobins; D064451:Hepcidins; D015850:Interleukin-6; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron
keywords: Ferritin; preeclampsia; prohepcidin; serum iron