title: Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine.
abstract: M13 bacteriophage (phage) has emerged as an attractive bionanomaterial owing to its genetically tunable surface chemistry and its potential to self-assemble into hierarchical structures. Furthermore, because of its unique nanoscopic structure, phage has been proposed as a model system in soft condensed physics and as a biomimetic building block for structured functional materials. Genetic engineering of phage provides great opportunities to develop novel nanomaterials with functional surface peptide motifs; however, this biological approach is generally limited to peptides containing the 20 natural amino acids. To extend the scope of phage applications, strategies involving chemical modification have been employed to incorporate a wider range of functional groups, including synthetic chemical compounds. In this review, we introduce the design of chemoselective phage functionalization and discuss how such a strategy is combined with genetic engineering for a variety of medical applications, as reported in recent literature.
authors.affiliation: College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea.
authors.forename: Woo-Jae
authors.initials: WJ
authors.lastname: Chung
authors.affiliation: College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea.
authors.forename: Doe-Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: BIO-IT Foundry Technology Institute, Pusan National University, Busan, Republic of Korea ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Yoo
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D017104:Bacteriophage M13 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D040761:Biomimetic Materials; D005818:Genetic Engineering; D050997:Nanomedicine; D049329:Nanostructures
chemical_list: D000596:Amino Acids
keywords: M13 bacteriophage; biomimetic structure; bionanomaterial; chemoselective modification; functionalization