title: Antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on experimentally induced myocardial infarcted rats.
abstract: The present study aims to evaluate the antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on isoproterenol-induced hyperlipidaemia and hypertrophy in rats. Rats were pretreated with zingerone (6 mg/kg body weight) daily for a period of 14 days and then induced myocardial infarction with isoproterenol (100 mg/kg body weight) on days 15 and 16. Isoproterenol increased serum creatine kinase and lactate dehydrogenase activities in the rats. Increased levels/concentrations of serum and heart cholesterol and triglycerides were observed in isoproterenol-induced myocardial infarcted rats. Isoproterenol also altered serum lipoproteins and the activity of liver 3-hydroxy-3-methyl glutaryl-coenzyme-A-reductase in the rats. The in vitro study revealed a very convincing reducing power of zingerone. Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy, by virtue of its antihyperlipidaemic, antihypertrophic, and reducing properties in isoproterenol-induced myocardial infarcted rats.
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, 608 002, India.
authors.forename: K L
authors.initials: KL
authors.lastname: Hemalatha
authors.forename: P
authors.initials: P
authors.lastname: Stanely Mainzen Prince
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007545:Isoproterenol; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy*; D020011:Protective Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000960:Hypolipidemic Agents; D020011:Protective Agents; C013738:zingerone; D006139:Guaiacol; D007545:Isoproterenol
keywords: Isoproterenol; Lipids; Lipoproteins; Myocardial Infarction; Zingerone