title: Fields of anhidrotic effects of abobotulinumtoxinA in patients with compensatory hyperhidrosis.
abstract: BACKGROUND
  Botulinum toxin type A can be used to treat compensatory hyperhidrosis (CHH), which presents areas of different intensity of sweating. More information about the anhidrotic effects is needed.
  
  
  OBJECTIVE
  To evaluate the fields of anhidrotic effects (FAEs) resulting from different doses (5 and 10 U), dilution, and depths of injection of abobotulinumtoxinA in patients with CHH.
  
  
  METHODS
  This was a prospective, single-center, pilot study. Ten patients suffering from CHH received 20 different injections of abobotulinumtoxinA on their backs. Midline received higher doses because of more intense sweating. The diameters of the FAEs were measured at 7, 30, and 180 days after the procedure.
  
  
  RESULTS
  Diameters of the FAEs were significantly larger at Day 30 (p < .0001) and did not significantly differ when compared with different injection depths and volumes. Points injected with 10 U exhibited significantly larger vertical diameters at 7, 30, and 180 days (p values .05, <.0001, and .043, respectively) than those injected with 5 U, but no statistical significance was observed for the horizontal diameters.
  
  
  CONCLUSIONS
  Areas of more intense sweating need higher doses to present similar diameters of the FAEs. Depth and volume of injections do not play a remarkable role on the FAEs diameters in patients suffering from CHH.
authors.affiliation: *Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil; †Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Doris
authors.initials: D
authors.lastname: Hexsel
authors.forename: Mariana
authors.initials: M
authors.lastname: Soirefmann
authors.forename: Manoela D
authors.initials: MD
authors.lastname: Porto
authors.forename: Juliana
authors.initials: J
authors.lastname: Schilling-Souza
authors.forename: Carolina
authors.initials: C
authors.lastname: Siega
mesh_terms: D000328:Adult; D001365:Axilla; D001415:Back; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D005260:Female; D006119:Groin; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D010865:Pilot Projects; D011446:Prospective Studies; D013546:Sweating / Q000187:drug effects*; D013848:Thigh; D013997:Time Factors; D055815:Young Adult
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA