title: [Molecular biology for sarcoma: useful or necessary?].
abstract: Sarcomas are a heterogeneous group of tumors. Their diagnosis is based on morphology and immunohistochemical profile, with categories of tumors according to the type of tissue that they resemble. Nevertheless, for several tumors, cellular origin is unknown. Molecular analysis performed in recent years allowed, combining histophenotype and genomics, better classifying such sarcomas, individualizing new entities and grouping some tumors. Simple and recurrent genetic alterations, such as translocation, mutation, amplification, can be identified in one of two sarcomas and appear as new diagnostic markers. Their identification in specialized laboratories in molecular pathology of sarcomas is often useful and sometimes necessary for a good diagnosis, leading to a heavy and multidisciplinary multi-step treatment.
authors.affiliation: Inserm U916 génétique et biologie des sarcomes, département de biopathologie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux, France; Université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France. Electronic address: a.neuville@bordeaux.unicancer.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Neuville
authors.affiliation: Inserm U916 génétique et biologie des sarcomes, département de biopathologie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux, France; Université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.affiliation: Inserm U916 génétique et biologie des sarcomes, département de biopathologie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chibon
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000276:immunology; D001859:Bone Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D005784:Gene Amplification; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D025202:Molecular Diagnostic Techniques; D009154:Mutation; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012509:Sarcoma / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D017422:Sequence Analysis, DNA; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion
keywords: Biologie moléculaire; Daily practice; Diagnosis; Diagnostic; Molecular biology; Routine; Sarcoma; Sarcomes