title: Organocatalytic enantioselective direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes.
abstract: A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
authors.affiliation: Department of Chemistry, National Taiwan Normal University , Taipei 11677, Taiwan, Republic of China.
authors.forename: Yi-Ru
authors.initials: YR
authors.lastname: Chen
authors.forename: Utpal
authors.initials: U
authors.lastname: Das
authors.forename: Meng-Hsien
authors.initials: MH
authors.lastname: Liu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Lin
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002090:Butyrophenones / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D005030:Ethylenes / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D002090:Butyrophenones; D005030:Ethylenes; D007769:Lactams