title: Fermentation pattern of infant formulas containing different prebiotics.
abstract: Prebiotics play a role in the development of intestinal flora. When exposed to unabsorbed food, such as prebiotic carbohydrates, intestinal bacteria produce hydrogen. Increases in hydrogen may signify a slower rate of fermentation or digestion. In this blinded, crossover study, infants (n = 13) consumed formula containing either 4 g/L galactooligosaccharide (GOS) or 4 g/L polydextrose (PDX) + GOS, and breath hydrogen was measured. Breath hydrogen was higher in the PDX/GOS group versus GOS alone (mean ± standard error, 25.35 ± 2.87 ppm vs 13.69 ± 2.87 ppm, P = 0.0001). These results indicate that the formula with PDX/GOS may have undergone slower digestion.
authors.affiliation: *Boston Children's Hospital, Boston, MA †Mead Johnson Nutrition, Evansville, IN ‡Boys Town National Research Hospital, Boys Town, NE.
authors.forename: Jon
authors.initials: J
authors.lastname: Vanderhoof
authors.forename: Paul
authors.initials: P
authors.lastname: Ferguson
authors.forename: Rosemary
authors.initials: R
authors.lastname: Pauley-Hunter
authors.forename: Laurel
authors.initials: L
authors.lastname: Prestridge
mesh_terms: D001942:Breast Feeding; D001944:Breath Tests; D018592:Cross-Over Studies; D004063:Digestion / Q000502:physiology; D005260:Female; D005285:Fermentation; D005503:Food Additives / Q000008:administration & dosage; D005936:Glucans / Q000008:administration & dosage*; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D008297:Male; D056692:Prebiotics / Q000008:administration & dosage*; D016037:Single-Blind Method; D014312:Trisaccharides / Q000008:administration & dosage*
chemical_list: D005503:Food Additives; D005936:Glucans; D056692:Prebiotics; D014312:Trisaccharides; C072242:4'-galactooligosaccharide; D006859:Hydrogen; C033375:polydextrose