title: Oil-soluble vitamins: illegal use for lip augmentation.
abstract: Fillers for lip augmentation have become more and more popular in recent years and seem to be indispensable in the cosmetic market nowadays. A series of six young females is presented who developed massive swellings and pain after vitamins A and/or E lip augmentation. The vitamins were extracted from gelatinous capsules (Gericaps [Adipharm EAD, Sofia, Bulgaria], Geritamins [Actavis EAD, Balkanpharma-Dubnitsa AD, Bulgaria], or vitamin E yellow gel capsules) and injected by unprofessional physicians and beauticians in different cosmetic centers. Physical examination revealed firm indurations of the lips and perioral skin, tenderness, erythema, and hard dermal nodules. Histological analysis revealed numerous round-to-ovoid cavities of varying sizes, resulting in a Swiss cheese-like appearance, consistent with lipogranulomas. The patients were treated with systemic and intralesional triamcinolone injections and broad-spectrum antibiotics with good clinical response. In conclusion, these cases demonstrate the danger of the use of unregistered products as fillers injected by unprofessional physicians and beauticians.
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: B
authors.initials: B
authors.lastname: Kamouna
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: J
authors.initials: J
authors.lastname: Kazandjieva
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Balabanova
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: L
authors.initials: L
authors.lastname: Dourmishev
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: Z
authors.initials: Z
authors.lastname: Negentsova
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Etugov
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: A
authors.initials: A
authors.lastname: Nikolova
authors.affiliation: Department of Dermatology and Venerology, Faculty of Medicine, University of Sofia, Sofia, Bulgaria.
authors.forename: L
authors.initials: L
authors.lastname: Miteva
authors.affiliation: Department of Dermatology, Inselspital, Universitätsspital Bern, Bern, Switzerland.
authors.forename: Eckart
authors.initials: E
authors.lastname: Haneke
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003357:Cosmetic Techniques / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007271:Injections, Intradermal; D008046:Lip / Q000473:pathology*; D009336:Necrosis / Q000139:chemically induced / Q000601:surgery; D009821:Oils / Q000009:adverse effects*; D014801:Vitamin A / Q000009:adverse effects*; D014810:Vitamin E / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D009821:Oils; D014801:Vitamin A; D014810:Vitamin E