title: The aspartyl (asparaginyl) beta-hydroxylase in carcinomas.
abstract: Aspartyl-(asparaginyl)-β-hydroxylase (AAH) is a member of the α-ketoglutarate-dependent dioxygenase family that catalyzes the hydroxylation of aspartyl and asparaginyl residues epidermal growth factor (EGF)-like domains of protein. In human tumorous cell lines from main systems of body, including tumor cells of kidney, throat, breast, liver, bladder, cervical and ovary, the AAH can be detected at both the transcriptional level and the translational level, and moreover, the AAH expression is usually increased, which is associated with the development and progression of carcinomas. Thus, AAH may play an important role in different carcinomas and may be a potential hub in carcinogenesis. In this review, we will discuss the role of AAH in carcinomas, focusing on liver cancers and other digestive tumors, lung cancers, and tumors of nervous system.
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Tang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Linjie
authors.initials: L
authors.lastname: Ye
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Shao
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Jin
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Huang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Junling
authors.initials: J
authors.lastname: Shi
mesh_terms: D004067:Digestive System Neoplasms / Q000201:enzymology*; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009423:Nervous System Neoplasms / Q000201:enzymology*
chemical_list: D006899:Mixed Function Oxygenases; C058291:aspartic acid 2-oxoglutarate-dependent dioxygenase