title: Platelet-activating factor acetylhydrolase and premature ovarian failure.
abstract: Premature ovarian failure (POF) appears to be a complex disease entity with several underlying etiopathogenic contributions including the possibility of multiple distinctly different autoimmune mechanisms, in which inflammatory autoimmunity targeted to ovarian-specific germline antigens (e.g., zona pellucida proteins or Mater) or differentiation/regulatory factors (e.g. inhibin-alpha) were regarded as one of the most crucial factors. Platelet-activating factor (PAF) and PAF class oxidized phospholipids stimulate the occurrence and development of inflammation and atherosclerosis. PAF acetylhydrolase (PAF-AH) can hydrolyze PAF and PAF class oxidized phospholipids and eventually prevent the body from the damage of these inflammatory mediators. These findings indicate a potential relationship between PAF-AH and POF thus have major implications for the future health of women who suffer with premature ovarian failure.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second, Hospital, Chengdu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Xue
authors.initials: X
authors.lastname: Xiao
authors.forename: Dan
authors.initials: D
authors.lastname: Shan
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.forename: Yanbiao
authors.initials: Y
authors.lastname: Liao
authors.forename: Liangzhi
authors.initials: L
authors.lastname: Xu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000502:physiology*; D005260:Female; D006801:Humans; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism; D016649:Primary Ovarian Insufficiency / Q000209:etiology* / Q000378:metabolism
chemical_list: D010743:Phospholipids; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase