title: PEAR1 is not a human hypertension-susceptibility gene.
abstract: OBJECTIVE
  Platelet endothelial aggregation receptor 1 (PEAR1) is a membrane protein involved in platelet contact-induced activation and sustained platelet aggregation. Experimental studies identified PEAR1, as a candidate gene that may be linked to the blood-pressure driven kidney injury in salt-sensitive Dahl rats.
  
  
  OBJECTIVE
  In a family-based European population study (mean age 39.7 years; 52.2% women), we searched for association of changes in blood pressure or incidence of hypertension with genetic variation in PEAR1.
  
  
  METHODS
  Among 1973 randomly recruited people, genotyped for PEAR1, we measured blood pressure at baseline and follow-up.
  
  
  RESULTS
  Median follow-up was 10.0 years. While accounting for family clusters and blood pressure at baseline and with adjustments applied for sex, age, body mass index, smoking and drinking, total cholesterol, and antihypertensive drug treatment, all associations of systolic and diastolic blood pressure changes with nine single nucleotide polymorphisms (SNPs) in PEAR1 were all non-significant (p ≥ 0.059). With similar adjustments, the incidence of hypertension (397 cases among 1532 participants were normotensive at baseline [25.9%]) was not related to the SNPs in PEAR1 (hazard ratios ≤ 1.09; p ≥ 0.09).
  
  
  CONCLUSIONS
  Our study suggests that PEAR1 is not a hypertension susceptibility gene in humans.
authors.affiliation: Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven , Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Olivi
authors.forename: Christophe
authors.initials: C
authors.lastname: Vandenbriele
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Gu
authors.forename: Erika
authors.initials: E
authors.lastname: Salvi
authors.forename: Simona Delli
authors.initials: SD
authors.lastname: Carpini
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Lotte
authors.initials: L
authors.lastname: Jacobs
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.forename: Lutgarde
authors.initials: L
authors.lastname: Thijs
authors.forename: Lorena
authors.initials: L
authors.lastname: Citterio
authors.forename: Daniele
authors.initials: D
authors.lastname: Cusi
authors.forename: Peter
authors.initials: P
authors.lastname: Verhamme
authors.forename: Jan A
authors.initials: JA
authors.lastname: Staessen
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051381:Rats; D020303:Rats, Inbred Dahl; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: C502809:PEAR1 protein, human; D011956:Receptors, Cell Surface
keywords: blood pressure; hypertension; platelet endothelial aggregation receptor 1; population science