title: Poly-ADP-ribosylation signaling during DNA damage repair.
abstract: Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the regulation of chromatin structure and DNA damage repair machineries by DNA damage-induced poly-ADP-ribosylation.
authors.affiliation: Department of Physiological Chemistry, Adolf Butenandt Institute, Ludwig-Maximilians-UniversitätMünchen, Butenandtstr.5, 81377 Munich, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Golia
authors.affiliation: Department of Physiological Chemistry, Adolf Butenandt Institute, Ludwig-Maximilians-UniversitätMünchen, Butenandtstr.5, 81377 Munich, Germany.
authors.forename: Hari R
authors.initials: HR
authors.lastname: Singh
authors.affiliation: Department of Physiological Chemistry, Adolf Butenandt Institute, Ludwig-Maximilians-UniversitätMünchen, Butenandtstr.5, 81377 Munich, Germany.
authors.forename: Gyula
authors.initials: G
authors.lastname: Timinszky
mesh_terms: D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002843:Chromatin; D011064:Poly Adenosine Diphosphate Ribose