title: A comparison of the efficacy of amoxicillin and nasal irrigation in treatment of acute sinusitis in children.
abstract: OBJECTIVE
  The efficacy of antibiotic therapy for acute sinusitis is controversial. This study aimed to compare the efficacies of amoxicillin with nasal irrigation and nasal irrigation alone for acute sinusitis in children.
  
  
  METHODS
  This randomized, double-blind, controlled study included 80 children aged 4-15 years with a clinical presentation of acute sinusitis. Patients were randomly assigned to receive either amoxicillin (80 mg/kg/day) in 3 divided doses orally for 14 days with saline nasal irrigation (for 5 days) and 0.25% phenylephrine (for 2 days) or the same treatment without amoxicillin. Clinical improvements in their initial symptoms were assessed on days 3, 14, 21, and 28.
  
  
  RESULTS
  On day 3, patients in the amoxicillin with nasal irrigation group showed significant clinical improvement (P=0.001), but there was no significant difference in the degree of improvement between the amoxicillin with nasal irrigation and nasal irrigation alone groups during follow-up (P>0.05). In addition, no significant differences were seen in age, sex, and degree of improvement between groups (P>0.05).
  
  
  CONCLUSIONS
  High-dose amoxicillin with saline nasal irrigation relieved acute sinusitis symptoms faster and more often than saline nasal irrigation alone. However, antibiotic treatment for acute sinusitis confers only a small therapeutic benefit over nasal irrigation.
authors.affiliation: Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Khoshdel
authors.affiliation: Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Panahande
authors.affiliation: Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mohamad Kazem
authors.initials: MK
authors.lastname: Noorbakhsh
authors.affiliation: Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Malek Ahmadi
authors.affiliation: Community Health Department, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Lotfizadeh
authors.affiliation: Nursing Department, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Parvin
keywords: Acute; Amoxicillin; Child; Nasal lavage; Sinusitis