title: Alteration of the Fetal Heart Rate Pattern Induced by the Use Of Clozapine during Pregnancy.
abstract: Patients treated with clozapine show autonomic dysregulation and cardiac repolarisation changes. As clozapine crosses the placenta, it could have an impact on the fetus heart rate. We reported a case of reduction of the fetal heart rate variability in a patient treated with clozapine during her pregnancy. This anomaly disappeared with fetal maturation and it did not jeopardize the fetal well-being. This side effect had already been described and pharmacologists and obstetricians should be aware that clozapine may be responsible for these fetal heart rate alterations.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Jeanne de Flandre, CHRU, Lille, France.
authors.forename: Laurie
authors.initials: L
authors.lastname: Guyon
authors.affiliation: Regional Center of Pharmacovigilance, CHRU, Lille, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Auffret
authors.affiliation: Regional Center of Pharmacovigilance, CHRU, Lille, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Coussemacq
authors.affiliation: Regional Center of Pharmacovigilance, CHRU, Lille, France.
authors.forename: Johana
authors.initials: J
authors.lastname: Béné
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Jeanne de Flandre, CHRU, Lille, France - Faculty of Medicine Henri Warembourg, Université Lille 2, Lille Nord de France, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Deruelle
authors.affiliation: Regional Center of Pharmacovigilance, CHRU, Lille, France - Faculty of Medicine Henri Warembourg, Université Lille 2, Lille Nord de France, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gautier
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine