title: Unique metastases of ALK mutated lung cancer activated to the adnexa of the uterus.
abstract: Anaplastic lymphoma kinase (ALK) fusion positive non-small cell lung cancer (NSCLC) is a relatively novel molecular subtype in lung cancer. ALK targeted therapies such as crizotinib increase survival benefit in this patient population. However, further understanding of the disease subtype including patterns of metastasis and pathways of treatment resistance are needed. We describe a 50 year-old-woman diagnosed with stage IV NSCLC, T2N3M1b, ALK fusion positive disease. Although her initial sites of metastasis included the liver and bone, her story is notable for crizotinib resistant growth of a metastatic lesion to her adnexa. This report brings to attention unique mechanisms of metastasis in ALK positive patients.
authors.affiliation: Department of Medicine, The University of Chicago, Chicago, IL, United States.
authors.forename: Allison H
authors.initials: AH
authors.lastname: West
authors.affiliation: Department of Obstetrics/ Gynecology, The University of Chicago, Chicago, IL, United States.
authors.forename: S Diane
authors.initials: SD
authors.lastname: Yamada
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, IL, United States.
authors.forename: Heber
authors.initials: H
authors.lastname: MacMahon
authors.affiliation: Marquette General Hematology Oncology, Marquette, MI, United States.
authors.forename: Sheetal S
authors.initials: SS
authors.lastname: Acharya
authors.affiliation: Foundation Medicine, Cambridge, MA, United States.
authors.forename: Siraj M
authors.initials: SM
authors.lastname: Ali
authors.affiliation: Foundation Medicine, Cambridge, MA, United States.
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Neurology, University of Chicago, Chicago, IL, United States.
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
authors.affiliation: Foundation Medicine, Cambridge, MA, United States.
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Miller
authors.affiliation: Department of Medicine, The University of Chicago, Chicago, IL, United States.
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
keywords: Adnexa; Anaplastic lymphoma kinase; Metastasis; Non-small cell lung cancer