title: Relationship between Initial Lens Transparency and Ocular Circulation in Adolescents with Type-1 Diabetes Mellitus, Unstable Glycaemia and Lipid Parameters.
abstract: BACKGROUND
  The aim of this study was to determine the relationships between lens opacity, vascular and lipid factors and retrobulbar blood flow parameters in type-1 diabetic (DM) adolescents.
  
  
  METHODS
  Glycated haemoglobin (HbA1c), total cholesterol (TCH), high- and low-density cholesterol, triglycerides (TG) and apolipoprotein B (ApoB) were determined in 28 patients with (DM-1) and without (DM-0) lens opacity and 18 controls. In the ophthalmic, central retinal (CRA) and temporal posterior ciliary (TPCA) arteries, the systolic (PSV), end-diastolic and mean blood flow velocities as well as pulsatility and resistance (RI) indices were measured.
  
  
  RESULTS
  Ten (35.71%) diabetic patients exhibited lens opacification. Higher TG and TCH levels in the DM-1 group and HbA1c level in the DM-0 and DM-1 groups were observed (P≤0.05). Diabetic patients had lower PSV and higher RI within CRA and TPCA (P≤0.05). Significant correlations between biochemical and blood flow parameters were found.
  
  
  CONCLUSIONS
  Glycaemic and lipid factors may play a vasoconstrictive role in retrobulbar endotheliopathy.
authors.affiliation: Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Modrzejewska
authors.affiliation: Laboratory of Biostatistics, West Pomeranian University of Technology, Szczecin, Poland.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Grzesiak
authors.affiliation: Laboratory of Biostatistics, West Pomeranian University of Technology, Szczecin, Poland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zaborski
authors.affiliation: Department of General and Dental Diagnostic Imaging, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Wilk
authors.affiliation: Pomeranian Medical University Hospital, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Modrzejewska
keywords: Cataract; Diabetes Mellitus, Type 1; Dyslipidemias; Hemoglobin A, Glycosylated