title: Association between the apelin rs2235306 gene polymorphism and metabolic syndrome.
abstract: OBJECTIVE
  The rs2235306 of apelin polymorphism has been shown to be associated with fasting plasma glucose levels and hypertension. The present study aimed to investigate the impact of the apelin rs2235306 gene polymorphism on the risk of metabolic syndrome (MeS) in a sample of the Iranian population.
  
  
  METHODS
  This population-based cross-sectional study was performed on 151 subjects with MeS and 149 without MeS, as defined by ATPIII criteria. Apelin rs2235306 polymorphism detection was done using the tetra amplification refractory mutation system-polymerase chain reaction. Because the apelin gene is located on the X chromosome, statistical analyses were conducted in a sex-specific manner.
  
  
  RESULTS
  Our findings proposed that the apelin rs2235306 polymorphism was not associated with MeS susceptibility in the codominant, dominant, and recessive inheritance models tested (OR = 0.93, 95% CI = 0.51-1.71 for TC vs. TT; OR = 2.39, 95% CI = 0.70-8.16 CC vs. TT; OR = 1.09, 95% CI = 0.62-1.93 for TC+CC vs. TT; and OR = 2.45, 95% CI = 0.73-8.21 for CC vs. TT+TC). We found that the apelin TC+CC genotypes were associated with lower HDL-cholesterol in women without MeS.
  
  
  CONCLUSIONS
  Our findings indicated no association between the apelin rs2235306 polymorphism and MeS. However, the results suggest that healthy females carrying apelin TC+CC genotypes have lower HDL-cholesterol in comparison with those carrying TT, which remains to be confirmed.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Rezaei
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.forename: Mahmoud Ali
authors.initials: MA
authors.lastname: Kaykhaei
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
mesh_terms: D000073861:Apelin; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D004586:Electrophoresis; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007492:Iran; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D016036:Seroepidemiologic Studies
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D008076:Cholesterol, HDL; D036341:Intercellular Signaling Peptides and Proteins