title: [Genomic instability in atherosclerosis].
abstract: A comparative study of the level of genomic instability, parameters of quantitative and structural mutations of chromosomes (aberration, aneuploidy, polyploidy) in lymphocyte cultures from patients with atherosclerosis of age 80 years and older (control group - 30-35 years old) was conducted. The possibility of correction of disturbed genomic indicators by peptide bioregulators - Livagen (Lys-Glu-Asp-Ala) and cobalt ions with separate application or in combination was also studied. Control was lymphocyte culture of two healthy respective age groups. It was also shown that patients with atherosclerosis exhibit high level of genomic instability in all studied parameters, regardless of age, which may suggest that there is marked increase in chromatin condensation in atherosclerosis. It was also shown that Livagen (characterized by modifying influence on chromatin) separately and in combination with cobalt ions, promotes normalization of altered genomic indicators of atherosclerosis in both age groups. The results show that Livagen separately and in combination with cobalt ions has impact on chromatin of patients with atherosclerosis. The identified protective action of Livagen proves its efficacy in prevention of atherosclerosis.
authors.forename: T A
authors.initials: TA
authors.lastname: Dzhokhadze
authors.forename: T Zh
authors.initials: TZh
authors.lastname: Buadze
authors.forename: M N
authors.initials: MN
authors.lastname: Gaiozishvili
authors.forename: N G
authors.initials: NG
authors.lastname: Kakauridze
authors.forename: T A
authors.initials: TA
authors.lastname: Lezhava
mesh_terms: D000328:Adult; D000367:Age Factors; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000235:genetics* / Q000503:physiopathology / Q000517:prevention & control; D002843:Chromatin / Q000187:drug effects / Q000235:genetics; D002869:Chromosome Aberrations / Q000187:drug effects*; D003035:Cobalt / Q000494:pharmacology; D005260:Female; D042822:Genomic Instability; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009154:Mutation; D009842:Oligopeptides / Q000494:pharmacology
chemical_list: D002843:Chromatin; C473185:Livagen; D009842:Oligopeptides; D003035:Cobalt