title: [Drug treatment of inpatients with chronic kidney disease in the acute care ward of a Swiss regional hospital].
abstract: BACKGROUND
  Optimal drug treatment may slow down the progression of chronic kidney disease (CKD) and reduce the associated complications. We conducted a study to assess the drug treatment of inpatients with CKD at their discharge.
  
  
  METHODS
  We retrospectively collected patient data from the electronic medical record of a Swiss regional hospital for two non-consecutive months. Patients were eligible if their glomerular filtration rate at discharge ranged between 15 and 60 mL/min/1.73 m2. Primary outcome was optimal CKD management, defined by drug treatment conforming to the following 3 criteria: (i) appropriate medication dosage relative to kidney function, (ii) absence of contraindicated medication, and (iii) treatment of any comorbidity/complication related to CKD; or alternatively by the recommendation of a kidney-specific follow-up.
  
  
  RESULTS
  The primary outcome was achieved by 45.1% of the 71 patients included. A total of 29.6% had at least one inappropriate medication dosage at discharge, 9.9% left with a drug contraindicated in case of CKD, and 73.2% presented at least one untreated comorbidity/complication at discharge. The most common untreated comorbidity was anaemia. A proposition for a specific follow-up was lacking in 39 of the 56 patients discharged with a non-optimal treatment.
  
  
  CONCLUSIONS
  Drug treatment of patients with CKD may be improved in our setting, especially the treatment of comorbidities/complications related to CKD and the specific ambulatory follow-up.
authors.affiliation: Service de pharmacie, hôpital du Valais, institut Central (ICHV), avenue du Grand-Champsec 86, 1951 Sion, Suisse.
authors.forename: Barbara
authors.initials: B
authors.lastname: Reutemann
authors.affiliation: Service de pharmacie, hôpital du Valais, institut Central (ICHV), avenue du Grand-Champsec 86, 1951 Sion, Suisse.
authors.forename: Johnny
authors.initials: J
authors.lastname: Beney
authors.affiliation: Service de pharmacie, hôpital du Valais, institut Central (ICHV), avenue du Grand-Champsec 86, 1951 Sion, Suisse.
authors.forename: Vera
authors.initials: V
authors.lastname: Jordan-von Gunten
authors.affiliation: Service de pharmacie, hôpital du Valais, institut Central (ICHV), avenue du Grand-Champsec 86, 1951 Sion, Suisse. Electronic address: lucien.roulet@gmail.com.
authors.forename: Lucien
authors.initials: L
authors.lastname: Roulet
mesh_terms: D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006760:Hospitalization; D006801:Humans; D008297:Male; D059065:Medication Reconciliation; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D012189:Retrospective Studies; D013557:Switzerland
keywords: Comorbidities; Comorbidités; Drug therapy; Inpatients; Insuffisance rénale chronique; Patients hospitalisés; Prevention; Prévention; Renal insuffiency, chronic - Survey, baseline; Traitement médicamenteux; État des lieux