title: [Impact of the economic crisis on the activity of a clinical research ethics committee].
abstract: OBJECTIVE
  Analyze the impact of economic and social crisis in volume and funding of clinical trials (CT) and observational studies (ES) from the activity of an Research Ethics Committee (REC).
  
  
  METHODS
  REC memories 2003-2012 were reviewed. Financing of evaluated projects, CT and OS were analyzed classifying them into four groups: 1) promoted by pharmaceutical industry, 2) by scientific societies with industry support, 3) by scientific societies with government support and 4) unfunding.Two periods were compared: pre-crisis (2003-2007) and crisis (2008-2012).
  
  
  RESULTS
  During 10 studied years, 744 protocols were evaluated: a 71% of group 1, a 9% of group 2, a 3% of group 3 and a 17% was no funding. Regarding OS, 40%, 5,4%, 8,6% and 46% were the groups 1, 2, 3 and 4 respectively. Analyzing crisis versus pre-crisis period, statistically significant differences were observed in the decreasing of number of CT phase 2 and 3 and in the rising EO. Comparing crisis related to the pre-crisis period, the Group 4 increased statistically significantly.
  
  
  CONCLUSIONS
  Evolution of total number of studies evaluated by REC tends to be maintained and even increased over time. REC maintains its activity and even increased at the expense of financing and unfunded OS.
authors.affiliation: Servicio de farmacia. Hospital Universitari Mútua Terrassa. Universitat de Barcelona.. susanarc@telefonica.net.
authors.forename: S
authors.initials: S
authors.lastname: Redondo Capafons
authors.affiliation: Servicio de farmacia. Hospital Universitari Mútua Terrassa. Universitat de Barcelona..
authors.forename: Paula
authors.initials: P
authors.lastname: Arcenillas
authors.affiliation: Servicio de farmacia. Hospital Universitari Mútua Terrassa. Universitat de Barcelona..
authors.forename: Nuria
authors.initials: N
authors.lastname: Giménez
authors.affiliation: Hospital Universitari Mútua Terrassa. Fundació per la Recerca Mútua Terrassa. Universitat de Barcelona. España..
authors.forename: Pablo
authors.initials: P
authors.lastname: March López
authors.affiliation: Servicio de farmacia. Hospital Universitari Mútua Terrassa. Universitat de Barcelona..
authors.forename: Laura
authors.initials: L
authors.lastname: Soriano
authors.affiliation: Servicio de farmacia. Hospital Universitari Mútua Terrassa. Universitat de Barcelona..
authors.forename: Ramon
authors.initials: R
authors.lastname: Pla
authors.affiliation: Hospital Universitari Mútua Terrassa. Fundació per la Recerca Mútua Terrassa. Universitat de Barcelona. España..
authors.forename: Salvador
authors.initials: S
authors.lastname: Quintana
mesh_terms: D035843:Biomedical Research; D002986:Clinical Trials as Topic / Q000191:economics*; D004345:Drug Industry / Q000191:economics; D057172:Economic Recession; D028744:Ethics Committees, Research / Q000191:economics* / Q000639:trends*; D006801:Humans; D064887:Observational Studies as Topic / Q000191:economics; D012109:Research Support as Topic / Q000639:trends*; D012958:Societies, Scientific; D013030:Spain