title: Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism.
abstract: OBJECTIVE
  Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH).
  
  
  METHODS
  This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects.
  
  
  RESULTS
  Mean IGF-I levels and median ALT levels were higher in patients with IH and PCOS than controls, but these differences were not statistically significant. The participants who had a homeostasis model assessment insulin resistance index (HOMA-IR) greater than 2.7 had significantly higher IGF-1 and ALT levels. ALT levels were positively correlated with body mass index, FG, insulin and HOMA-IR.
  
  
  CONCLUSIONS
  The study illustrated that IGF-1 and ALT levels were significantly higher in patients with increased insulin resistance. Due to short disease duration in younger participants, we did not observe any correlation between IGF-1 and hyperinsulinemia. These findings suggest that increased hepatic production of IGF-I and ALT might be an early indicator of insulin resistance in hirsutism.
authors.forename: Evrim
authors.initials: E
authors.lastname: Çakir
authors.forename: Oya
authors.initials: O
authors.lastname: Topaloğlu
authors.forename: Nujen
authors.initials: N
authors.lastname: Çolak Bozkurt
authors.forename: Başak
authors.initials: B
authors.lastname: Karbek Bayraktar
authors.forename: Aşkın
authors.initials: A
authors.lastname: Güngüneş
authors.forename: Müyesser
authors.initials: M
authors.lastname: Sayki Arslan
authors.forename: İlknur
authors.initials: İ
authors.lastname: Öztürk Ünsal
authors.forename: Esra
authors.initials: E
authors.lastname: Tutal
authors.forename: Bekir
authors.initials: B
authors.lastname: Uçan
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delıbaşi
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D005260:Female; D006628:Hirsutism / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D007334:Insulin-Like Growth Factor I; D000410:Alanine Transaminase