title: Novel drug delivery system: an immense hope for diabetics.
abstract: BACKGROUND
  Existing medication systems for the treatment of diabetes mellitus (DM) are inconvenient and troublesome for effective and safe delivery of drugs to the specific site. Therefore, investigations are desired to deliver antidiabetics using novel delivery approaches followed by their commercialization.
  
  
  OBJECTIVE
  The present review aims to provide a compilation on the latest development in the field of novel drug delivery systems (NDDSs) for antidiabetics with special emphasis on particulate, vesicular and miscellaneous systems.
  
  
  METHODS
  Review of literature (restricted to English language only) was done using electronic databases like Pubmed® and Scirus, i.e. published during 2005-2013. The CIMS/MIMS India Medical Drug Information eBook was used regarding available marketed formulation of antidiabetic drugs. Keywords used were "nanoparticle", "microparticle", "liposomes", "niosomes", "transdermal systems", "insulin", "antidiabetic drugs" and "novel drug delivery systems". Single inclusion was made for one article. If in vivo study was not done then article was seldom included in the manuscript.
  
  
  RESULTS
  The curiosity to develop NDDSs of antidiabetic drugs with special attention to the nanoparticulate system followed by microparticulate and lipid-based system is found to emerge gradually to overcome the problems associated with the conventional dosage forms and to win the confidence of end users towards the higher acceptability.
  
  
  CONCLUSIONS
  In the current scientific panorama when the area of novel drug delivery system has been recognized for its palpable benefits, unique potential of providing physical stability, sustained and site-specific drug delivery for a scheduled period of time can open new vistas for precise, safe and quality treatment of DM.
authors.affiliation: a Herbal Medicinal Products Department , CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow , Uttar Pradesh , India and.
authors.forename: Vineet Kumar
authors.initials: VK
authors.lastname: Rai
authors.affiliation: a Herbal Medicinal Products Department , CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow , Uttar Pradesh , India and.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Mishra
authors.affiliation: b Department of Pharmaceutics , National Institute of Pharmaceutical Education and Research , Mohali , Punjab , India.
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Agrawal
authors.affiliation: b Department of Pharmaceutics , National Institute of Pharmaceutical Education and Research , Mohali , Punjab , India.
authors.forename: Sanyog
authors.initials: S
authors.lastname: Jain
authors.affiliation: a Herbal Medicinal Products Department , CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow , Uttar Pradesh , India and.
authors.forename: Narayan Prasad
authors.initials: NP
authors.lastname: Yadav
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D008081:Liposomes
keywords: Antidiabetic drugs; diabetes; drug delivery; particulate systems; vesicular systems