title: Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy.
abstract: OBJECTIVE
  Intraabdominal hypertension is a common occurrence, especially in intensive care unit patients, and it has high mortality and morbidity rates. The onset is commonly insidious and the poor prognosis is attributed to the long delay in diagnosis. Unfortunately, diagnosis is often delayed until loss of function in the affected tissues has already occurred. The aim of this study was to determine the predictive value of mean platelet volume (MPV) in assessing the risk of intraabdominal hypertension.
  
  
  METHODS
  Pneumoperitoneum during elective laparoscopic cholecystectomy was used as a model for intraabdominal hypertension. The study included 103 patients who met the inclusion criteria. MPV evaluations were made at 3 distinct times during laparoscopic cholecystectomy based on the actual intraabdominal pressure.
  
  
  RESULTS
  MPV values during preinsufflation, insufflation, and desufflation were 8.483 fL (range: 6.7 to 11.1), 8.901 fL (range: 6.8 to 11.9), and 8.538 fl (range: 5.8 to 10.9), respectively. A statistically significant increase in MPV values was found during high intraabdominal pressures (P < 0.001). A significant decrease in MPV values was also detected with desufflation (P < 0.001).
  
  
  CONCLUSIONS
  Increasing MPV values may reflect increased intraabdominal pressures, which may have a clinical implementation in intraabdominal hypertension.
authors.affiliation: Department of Surgery, Afyon Kocatepe University, Afyonkarahisar, Turkey. bahadircelep@hotmail.com
authors.forename: Rüçhan Bahadir
authors.initials: RB
authors.lastname: Celep
authors.forename: Şahin
authors.initials: Ş
authors.lastname: Kahramanca
authors.forename: Mustafa
authors.initials: M
authors.lastname: Özsoy
authors.forename: Cem
authors.initials: C
authors.lastname: Azili
authors.forename: Süleyman
authors.initials: S
authors.lastname: Çetinkünar
authors.forename: Ahmet Oğuz
authors.initials: AO
authors.lastname: Hasdemir
authors.forename: Hakan
authors.initials: H
authors.lastname: Güzel
authors.forename: Gülay
authors.initials: G
authors.lastname: Özgehan
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Çolhan
authors.forename: Tevfik Hadi
authors.initials: TH
authors.lastname: Küçükpinar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D059325:Intra-Abdominal Hypertension / Q000097:blood*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011027:Pneumoperitoneum; D011446:Prospective Studies; D014421:Turkey; D055815:Young Adult