title: ExcellmiRDB for translational genomics: a curated online resource for extracellular microRNAs.
abstract: A large number of studies have suggested extracellular microRNAs (microRNAs in biofluids) as potential noninvasive biomarkers for pathophysiological conditions such as cancer. However, reported differentially expressed signatures of extracellular miRNAs in diseases are not uniformly consistent among studies. Here, we present "ExcellmiRDB", a curated online database that provides integrated information about miRNAs levels in biofluids in a user-friendly way. Although many miRNA databases, including disease-oriented databases, have been launched before, the ExcellmiRDB is so far the only one specialized for storing curated data on miRNA levels in biofluid samples. At present, ExcellmiRDB has 2773 disease-extracellular miRNAs and 1108 biofluid-extracellular miRNAs relationships curated from 108 articles selected from more than 600 surveyed PubMed abstracts. Information about 992 miRNAs, 82 diseases, 21 biofluids, 8 species, 63 normalization reference genes, 5 techniques, 14 GEO profiles accession numbers, 7 human ethnic groups, and 18 compared clinical biomarkers have been provided in the database. A user can query ExcellmiRDB by selecting a disease or a miRNA or a biofluid. Additionally, the database provides two online network graphs to visualize and interact with the content of the database. The first network shows disease-extracellular miRNAs relationships, along with expression patterns and number of articles for a relationship. The second network visualizes biofluid-extracellular miRNAs relationships showing miRNAs spectrum across different types of biofluids. In conclusion, ExcellmiRDB is a new innovative resource for both academic and industrial researchers in translational omics who are developing miRNA biomarkers for noninvasive diagnostic or prognostic technologies. ExcellmiRDB is publicly available on www.excellmirdb.brfjaisalmer.com/.
authors.affiliation: 1 Department of Botany, University of Rajasthan , Jaipur, India .
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Barupal
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Saini
authors.forename: Tara
authors.initials: T
authors.lastname: Chand
authors.forename: Arun
authors.initials: A
authors.lastname: Meena
authors.forename: Surendra
authors.initials: S
authors.lastname: Beniwal
authors.forename: Jetha Ram
authors.initials: JR
authors.lastname: Suthar
authors.forename: Narendra
authors.initials: N
authors.lastname: Meena
authors.forename: Sumita
authors.initials: S
authors.lastname: Kachhwaha
authors.forename: Shanker Lal
authors.initials: SL
authors.lastname: Kothari
mesh_terms: D023281:Genomics / Q000379:methods*; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs