title: Procalcitonin and intestinal ischemia: a review of the literature.
abstract: Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery. At present, there are no diagnostic tools for the early diagnosis of intestinal ischemia. In the last decade, procalcitonin (PCT) has been suggested as a marker of this condition. Here, we review the use of PCT as a diagnostic tool for intestinal ischemia. Two reviewers independently searched the PubMed and EMBASE databases for articles on intestinal ischemia and PCT. They then considered (1) the criteria applicable to preclinical and clinical data; and (2) PCT's predictive value in the diagnosis of intestinal ischemia. Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy. Between 1993 and 2014, seven studies (including two preclinical studies and five clinical studies) dealt with the use of PCT to diagnose intestinal ischemia. Procalcitonin's sensitivity, specificity, positive predictive value and negative predictive value ranged between 72% and 100%; 68% and 91%; 27% and 90% and 81% and 100%, respectively. The area under the receiver operating characteristic curve ranged from 0.77 to 0.92. In view of the preclinical and clinical data, we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia.
authors.affiliation: Cyril Cosse, Charles Sabbagh, Saïd Kamel, INSERM U1088, Jules Verne University of Picardie, 80054 Amiens, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Cosse
authors.affiliation: Cyril Cosse, Charles Sabbagh, Saïd Kamel, INSERM U1088, Jules Verne University of Picardie, 80054 Amiens, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Sabbagh
authors.affiliation: Cyril Cosse, Charles Sabbagh, Saïd Kamel, INSERM U1088, Jules Verne University of Picardie, 80054 Amiens, France.
authors.forename: Saïd
authors.initials: S
authors.lastname: Kamel
authors.affiliation: Cyril Cosse, Charles Sabbagh, Saïd Kamel, INSERM U1088, Jules Verne University of Picardie, 80054 Amiens, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Galmiche
authors.affiliation: Cyril Cosse, Charles Sabbagh, Saïd Kamel, INSERM U1088, Jules Verne University of Picardie, 80054 Amiens, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Regimbeau
mesh_terms: D000818:Animals; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000098:blood supply* / Q000503:physiopathology; D007511:Ischemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: Diagnosis; Intestinal; Ischemia; Procalcitonin; Review