title: MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics.
abstract: Pharmacodynamics and toxicodynamics are the study of the biochemical and physiological effects of therapeutic agents and toxicants and their mechanisms of action. MALDI-MS imaging offers great potential for the study of pharmaco/toxicodynamic responses in tissue owing is its ability to study multiple biomarkers simultaneously in a label-free manner. Here, existing examples of such studies examining anticancer drugs and topically applied treatments are described. Examination of the literature shows that the use of MS imaging in pharmaco/toxicodynamic studies is in fact quite low. The reasons for this are discussed and potential developments in the methodology that might lead to its further use are described.
authors.affiliation: Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK.
authors.forename: Ekta
authors.initials: E
authors.lastname: Patel
authors.forename: Laura M
authors.initials: LM
authors.lastname: Cole
authors.forename: Robert
authors.initials: R
authors.lastname: Bradshaw
authors.forename: Afnan
authors.initials: A
authors.lastname: Batubara
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Mitchell
authors.forename: Simona
authors.initials: S
authors.lastname: Francese
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Clench
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D003952:Diagnostic Imaging; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*