title: Copper-promoted hydration and annulation of 2-fluorophenylacetylene derivatives: from alkynes to benzo[b]furans and benzo[b]thiophenes.
abstract: An efficient copper-promoted hydration reaction and its application in the synthesis of benzo[b]furan and benzo[b]thiophene derivatives is presented starting from readily available 2-fluorophenylacetylene derivatives. The key annulation step involves the hydration of the C-F bond of 2-fluorophenylacetylene derivatives followed by an intramolecular annulation to afford benzo[b]furan and benzo[b]thiophene derivatives. Moreover, structurally important 2,2'-bisbenzofuran scaffolds are provided in good yields.
authors.affiliation: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, Guangdong Province, 529090, China.
authors.forename: Yibiao
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, Guangdong Province, 529090, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: BASF Catalyst, 23800 Mercantile Road, Beachwood, Ohio 44124, USA.
authors.forename: Xiaohang
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, Guangdong Province, 529090, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, Guangdong Province, 529090, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
keywords: C–F activation; annulation; benzo[b]furan; copper-promoted; heterocycle