title: Andrographolide and analogues in cancer prevention.
abstract: Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It showed potentials as chemopreventive agents by suppressing growth of cancer cells by inhibiting NF-kappaB, PI3K/AKT and other kinase pathways and by inducing apoptosis. Andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like Bax, p53, and activated caspases. Andrographolide was successfully used as an antineoplastic drug in cancer chemotherapy. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide and analogues need to be subjected to further clinical and biomedical studies in cancer chemoprevention. Andrographolide could be potent anticancer agent when used in combination with other chemotherapeutic agents.
authors.affiliation: Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India.
authors.forename: Siddhartha Kumar
authors.initials: SK
authors.lastname: Mishra
authors.affiliation: Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Tripathi
authors.affiliation: Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Shukla
authors.affiliation: Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India.
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India.
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
mesh_terms: D035685:Andrographis; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004224:Diterpenes; D010936:Plant Extracts; C030419:andrographolide