title: Near infrared activation of an anticancer Pt(IV) complex by Tm-doped upconversion nanoparticles.
abstract: The Pt(IV) complex cis,cis,trans-[Pt(NH3)2(Cl)2(O2CCH2CH2CO2H)2] is photoactivated by near infrared light (980 nm) using NaYF4:Yb(3+)/Tm(3+)@NaYF4 core-shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH2 affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing Pt(II) species upon NIR light excitation.
authors.affiliation: CIC biomaGUNE, Paseo de Miramón 182, 20009, Donostia, Euskadi, Spain. lsalassa@cicbiomagune.es.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ruggiero
authors.forename: Javier
authors.initials: J
authors.lastname: Hernández-Gil
authors.forename: Juan C
authors.initials: JC
authors.lastname: Mareque-Rivas
authors.forename: Luca
authors.initials: L
authors.lastname: Salassa
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D007259:Infrared Rays; D053758:Nanoparticles / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010782:Photolysis; D011355:Prodrugs / Q000737:chemistry; D013932:Thulium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011355:Prodrugs; D013932:Thulium