title: A comparative analysis of predictors for 1-year recurrent acute coronary syndromes events, by age group: the Greek observational study of ACS (GREECS).
abstract: OBJECTIVE
  To evaluate the potential differences in risk factors' profile for in-hospital mortality and up to 1-year prognosis, between younger and older patients with first acute coronary syndromes (ACS).
  
  
  METHODS
  From October 2003 to September 2004, 1323 patients with first ACS event from 6 urban and rural Greek hospitals were enrolled into the study, classified as those < 65 years and ≥ 65 years old. Multiple logistic regression analysis was used to evaluate the association between socio-demographic, lifestyle, clinical characteristics and the disease prognosis for one year after discharge.
  
  
  RESULTS
  The men-to-women ratio was 8.5-to-1.5 for those < 65 years, whereas, it was 6.6-to-3.4 for those above 65 years (p < 0.001). In-hospital deaths and recurrent event within 30-days was higher among older patients (p < 0.001). After the period of 6-months, the event-rate was higher among the younger patients (p < 0.001). Current smoking was associated with increased risk of 1-month recurrent events, in patients < 65 years (p < 0.05). Myocardial infarction and history of diabetes were associated with increased risk in older patients (p < 0.1).
  
  
  CONCLUSIONS
  Age-specific identification of the risk factors for recurrent events may have important clinical and public health implications and lead to the development of more effective risk reduction strategies.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. Electronic address: d.b.panagiotakos@usa.net.
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Venetia
authors.initials: V
authors.lastname: Notara
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Ekavi N
authors.initials: EN
authors.lastname: Georgousopoulou
authors.affiliation: First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
authors.affiliation: Cardiology Clinic, General Hospital of Lamia, Lamia, Greece.
authors.forename: Antonis
authors.initials: A
authors.lastname: Antonoulas
authors.affiliation: Cardiology Clinic, General Hospital of Karditsa, Karditsa, Greece.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Kogias
authors.affiliation: Cardiology Clinic, General Hospital of Chalkida, Chalkida, Greece.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Mantas
authors.affiliation: Cardiology Clinic, General Hospital of Zakynthos Island, Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Stravopodis
authors.affiliation: Cardiology Clinic, General Hospital of Kalamata, Kalamata, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Zombolos
authors.affiliation: First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017028:Caregivers; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006115:Greece / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000401:mortality; D010359:Patient Readmission; D011379:Prognosis; D011788:Quality of Life; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D055815:Young Adult
keywords: Acute coronary syndromes; Elderly; Epidemiology; Risk factors