title: Inflammation in the pathogenesis of ischemic stroke.
abstract: Ischemic stroke is a common cause of permanent disability in adults worldwide. Inflammation plays a significant role in the pathogenesis of ischemic stroke and its mechanism is complex. Both pro-inflammatory and anti-inflammatory mediators are involved in the pathogenesis of ischemic stroke, an imbalance of which leads to inflammation. Inflammatory cells from both the innate and acquired immune systems are involved in ischemic stroke-related inflammation; processes that are linked by the action of interleukin-17A (IL-17A). Although most inflammatory cells promote inflammation, T regulatory cells (Tregs) may have a protective function at the early stages of an ischemic injury, but a negative role during later stages. However, the precise mechanism of inflammation in ischemic stroke remains elusive; further understanding of it may provide new ideas for the prevention and treatment of ischemic stroke. In this review, we discuss the role of pro-inflammatory and anti-inflammatory mediators and related immune cells in the pathogenesis of ischemic stroke.
authors.affiliation: Department of Acupuncture, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Pei
authors.affiliation: Department of Acupuncture, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: You
authors.affiliation: Department of Acupuncture, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Fu
mesh_terms: D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000503:physiopathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators