title: Increased TSH in obesity: Evidence for a BMI-independent association with leptin.
abstract: OBJECTIVE
  This study aimed to determine whether the association between thyroid-stimulating hormone (TSH) and body mass index (BMI) is related to leptin concentration in obese individuals.
  
  
  METHODS
  Plasma TSH and leptin assays were performed in 800 consecutive patients, hospitalized for a nutritional checkup, with a BMI ≥ 30 kg/m(2). Various anthropometric, hormonal and metabolic parameters, including age, weight, BMI, insulin, leptin and TSH, were measured or calculated. Univariate and multivariate regression analyses were performed to identify any significant relationships between these parameters. Also, characteristics of the patients in the lowest and highest quartiles of TSH distribution were compared.
  
  
  RESULTS
  TSH was positively correlated with both BMI and leptin. When multiple regression analysis was performed, TSH and leptin maintained a significant association independent of BMI. Patients in the fourth quartile of TSH distribution displayed higher BMI and higher leptin levels in comparison to the first quartile.
  
  
  CONCLUSIONS
  Our study has confirmed an increase in TSH in conjunction with BMI in obese subjects. This increase was correlated with leptin independently of BMI. It is hypothesized that the increase in TSH observed in obese subjects was the consequence of both fat mass accumulation and a positive energy-balance.
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: C
authors.initials: C
authors.lastname: Bétry
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Challan-Belval
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: A
authors.initials: A
authors.lastname: Bernard
authors.affiliation: Department of Biochemistry, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France; Centre Européen pour la Nutrition et la Santé (CENS), Centre de Recherche en Nutrition Humaine Rhône-Alpes, Unité INSERM 1060, laboratoire CARMEN, Université Claude-Bernard Lyon 1, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: A
authors.initials: A
authors.lastname: Charrié
authors.affiliation: Department of Biochemistry, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France; Centre Européen pour la Nutrition et la Santé (CENS), Centre de Recherche en Nutrition Humaine Rhône-Alpes, Unité INSERM 1060, laboratoire CARMEN, Université Claude-Bernard Lyon 1, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: J
authors.initials: J
authors.lastname: Drai
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France; Centre Européen pour la Nutrition et la Santé (CENS), Centre de Recherche en Nutrition Humaine Rhône-Alpes, Unité INSERM 1060, laboratoire CARMEN, Université Claude-Bernard Lyon 1, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: M
authors.initials: M
authors.lastname: Laville
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France; Centre Européen pour la Nutrition et la Santé (CENS), Centre de Recherche en Nutrition Humaine Rhône-Alpes, Unité INSERM 1060, laboratoire CARMEN, Université Claude-Bernard Lyon 1, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France.
authors.forename: C
authors.initials: C
authors.lastname: Thivolet
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Specialized and Integrated Center for Obesity Management, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France; Centre Européen pour la Nutrition et la Santé (CENS), Centre de Recherche en Nutrition Humaine Rhône-Alpes, Unité INSERM 1060, laboratoire CARMEN, Université Claude-Bernard Lyon 1, 165, chemin du Grand-Revoyet, 69530 Pierre-Bénite, France. Electronic address: emmanuel.disse@chu-lyon.fr.
authors.forename: E
authors.initials: E
authors.lastname: Disse
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood*
chemical_list: D020738:Leptin; D013972:Thyrotropin
keywords: Energy-balance; Leptin; Obesity; TSH