title: Recent advances bioactive 1,2,4-triazole-3-thiones.
abstract: Triazoles are heterocyclic compounds which have a five-membered ring of two carbon atoms and three nitrogen atoms. These structures have been interest in the development of novel compounds with anticonvulsant, antidepressant, antioxidant, anti-inflammatory, analgesic, antinociceptive, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, anti-parasitic, anti-urease and other activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety.
authors.affiliation: Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydapaşa, 34668 İstanbul, Turkey. Electronic address: gkucukguzel@marmara.edu.tr.
authors.forename: Ş Güniz
authors.initials: ŞG
authors.lastname: Küçükgüzel
authors.affiliation: Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydapaşa, 34668 İstanbul, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Çıkla-Süzgün
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D013871:Thiones / Q000737:chemistry* / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D013871:Thiones; D014230:Triazoles; C045575:1,2,4-triazole
keywords: 1,2,4-Triazole-3-thione; Anastrozole; Diflunisal 1,2,4-triazole; Etodolac 1,2,4-triazole; Fluconazole; Ribavirin