title: Systemic sclerosis in 2014: Advances in cohort enrichment shape future of trial design.
abstract: The treatment and study of systemic sclerosis (SSc) is entering a new era with the reporting and preparation of several randomized controlled trials according to an improved understanding of SSc pathogenesis. Advances in trial designs reported in 2014 should now be built upon with further improvements to patient selection to enable targeting of therapies to specific subgroups of patients with SSc.
authors.affiliation: Department of Rheumatology A, Medicine Faculty, Paris Descartes University, 27 Rue du Faubourg Saint Jacques, Cochin Hospital, 75014 Paris, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Allanore
authors.affiliation: Division of Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8091 Zürich, Switzerland.
authors.forename: Oliver
authors.initials: O
authors.lastname: Distler
mesh_terms: D015331:Cohort Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D057285:Precision Medicine; D012107:Research Design; D012219:Rheumatology / Q000639:trends*; D012595:Scleroderma, Systemic / Q000401:mortality / Q000628:therapy*