title: The relationship between iodine intake and serum thyroglobulin in the general population.
abstract: The relationship is shown between a concentration of urinary iodine and serum thyroglobulin in population studies carried out on a general population that was randomly selected from the registry of the General Health Insurance Company (individuals aged 6-98 years, 1751 males, 2420 females). The individuals were divided into subgroups with a urinary iodine concentration of <50, 50-99, 100-199, 200-299 and >/=300 microg/l. The mean and median of thyroglobulin were calculated in these subgroups. Tg concentrations were dependent on gender (males<females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine <300 microg/l and the age under 65 years. Upper nonparametric tolerance limits of thyroglobulin in relation to iodine intake were calculated in subgroup of normal individuals (n=1858, thyroglobulin, urinary iodine, thyrotropin and free thyroxine were within the normal reference range). Upper limits were dependent on gender and age. The total value of upper limits is 44 microg/l; for individuals aged 6-17 years it is 39.1 microg/l; 18-65 years = 51.4 microg/l and 66-98 years = 60.6 microg/l. In general, thyroglobulin serum concentrations higher than 40 microg/l should be an indicator for determining urinary iodine.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. rbilek@endo.cz.
authors.forename: R
authors.initials: R
authors.lastname: Bílek
authors.forename: J
authors.initials: J
authors.lastname: Čeřovská
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002648:Child; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012042:Registries; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012727:Sex Characteristics; D017678:Sex Distribution; D013954:Thyroglobulin / Q000097:blood*; D055815:Young Adult
chemical_list: D013954:Thyroglobulin; D007455:Iodine