title: Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series.
abstract: Non-alcoholic fatty liver disease (NAFLD) is a relevant issue in public health owing to its epidemiological burden. It represents the most common chronic liver disease in the general population and is expected to increase in future as a result of an ageing population. The only currently recommended treatment for NAFLD is lifestyle modification. However, literature reports pre-clinical and clinical studies on the use of antioxidant supplementation in NAFLD. A new antioxidant complex, called Bilirel (BIL) (Pharmaluce, Republic of San Marino), have recently introduced in the Italian market. However no data are reported on his effects on liver steatosis. Here we report on a cases series of seven overweight patients with NAFLD, in which the association of an Italian Mediterranean diet, increased physical activity, and daily administration of two pills of BIL for 6 weeks, have induced the rapid improvement of fatty liver accumulation, glucose and lipid metabolism, and weight reduction.
authors.affiliation: Department of Health Sciences, University Magna Græcia, Catanzaro, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.affiliation: Department of Health Sciences, University Magna Græcia, Catanzaro, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Peta
authors.affiliation: Department of Pharmacy, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D015331:Cohort Studies; D038441:Diet, Mediterranean; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D050177:Overweight / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D012189:Retrospective Studies; D040242:Risk Reduction Behavior; D015431:Weight Loss
chemical_list: D000975:Antioxidants