title: Brain and central nervous system cancer incidence in navarre (Spain), 1973-2008 and projections for 2014.
abstract: Different studies have pointed out Navarre as one of the regions of Spain with the highest incidence rates of brain and other central nervous system (CNS) cancer. Trend analysis for cancer incidence rates for long periods of time, might help determining risk factors as well as, assessing prevention actions involved in this disease. The objective of this study was to describe the incidence of brain and CNS cancer using data from the population-based cancer registry of Navarre, (Spain) during the period 1973-2008 and provide forecast figures up to-2014. Crude and age-standardized (world population) incidence rates of brain cancer per 100,000 person-years were calculated by the direct method separately by gender, area (Pamplona and others), and age-groups. Penalized splines for smoothing rates in the temporal dimensions were applied in order to estimate and forecast cancer incidence rates. Age-adjusted incidence rates showed an increase over the study and forecast periods in both sexes more marked in women than in men. Higher incidence rates were observed in men compared with women but the differences became smaller with time. The increase was due to the rise of rates in the oldest age groups since the rates for younger age groups remained stable or decreased over time. As the entire aetiology of brain and other CNS cancer is not still clear, keep promoting healthful lifestyles for cancer primary prevention among the whole population is necessary.
authors.affiliation: 1. Department of Statistics and O. R., Public University of Navarre, Spain. ; 3. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: J
authors.initials: J
authors.lastname: Etxeberria
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain.
authors.forename: E San
authors.initials: ES
authors.lastname: Román
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain. ; 3. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: R
authors.initials: R
authors.lastname: Burgui
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain. ; 3. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: M
authors.initials: M
authors.lastname: Guevara
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain. ; 4. Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Spain.
authors.forename: C
authors.initials: C
authors.lastname: Moreno-Iribas
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Urbina
authors.affiliation: 2. Epidemiology Unit, Navarre Public Health Institute, Spain. ; 3. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
keywords: Brain Cancer Incidence; Population-based cancer registries; Projections; Spain; Trend analysis