title: Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema: a systemic review and Meta-analysis.
abstract: OBJECTIVE
  To further evaluate the efficacy and safety of intravitreal bevacizumab (IVB) versus macular photocoagulation (MPC) in treatment of diabetic macular edema (DME) by Meta-analysis.
  
  
  METHODS
  Pertinent publications were identified through systemic searches of PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register up to 30 November, 2013. Changes in central macular thickness (CMT) in µm and best-corrected visual acuity (BCVA) in logMAR equivalents were extracted at 1, 3, 6, 12 and 24mo after initial treatment, and a Meta-analysis was carried out to compare results between groups receiving IVB and MPC.
  
  
  RESULTS
  Five randomized controlled trial (RCTs) and one high-quality comparative study were identified and included. Our Meta-analysis revealed that both IVB and MPC resulted in the improvements of CMT and BCVA in eyes with DME at 1mo after initial treatment, with IVB being significantly superior to MPC (P=0.01 and 0.02, respectively). The improvements of both measure outcomes at 3, 6, 12 and 24mo after treatment did not vary significantly between the IVB groups and MPC groups (CMT at 3mo, P=0.85; at 6mo, P=0.29; at 12mo, P=0.56; at 24mo, P=0.71; BCVA at 3mo, P=0.31; at 6mo, P= 0.30; at 12mo, P=0.23; at 24mo, P=0.52). However, the number of observed adverse events was low in all studies.
  
  
  CONCLUSIONS
  Current evidence shows IVB treatment trends to be more effective in improvements of macular edema and vision in eyes with DME at an earlier follow up (1mo) compared with MPC. At other time, both interventions have comparable efficacy without statistical significances.
authors.affiliation: Department of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, China.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Shen
keywords: Meta-analysis; bevacizumab; diabetic macular edema; intravitreal injection; photocoagulation