title: Periodic Fever and Neutrophilic Dermatosis: Is It Sweet's Syndrome?
abstract: A 7-year-old boy with high grade fever (39°C) and warm, erythematous, and indurated plaque above the left knee was referred. According to the previous records of this patient, these indurated plaques had been changed toward abscesses formation and then spontaneous drainage had occurred after about 6 to 7 days, and finally these lesions healed with scars. In multiple previous admissions, high grade fever, leukocytosis, and a noticeable increase in erythrocyte sedimentation rate and C-reactive protein were noted. After that, until 7th year of age, he had shoulder, gluteal, splenic, kidney, and left thigh lesions and pneumonia. The methylprednisolone pulse (30 mg/kg) was initiated with the diagnosis of Sweet's syndrome. After about 10-14 days, almost all of the laboratory data regressed to nearly normal limits. After about 5 months, he was admitted again with tachypnea and high grade fever and leukocytosis. After infusion of one methylprednisolone pulse, the fever and tachypnea resolved rapidly in about 24 hours. In this admission, colchicine (1 mg/kg) was added to the oral prednisolone after discharge. In the periodic fever and neutrophilic dermatosis, the rheumatologist should search for sterile abscesses in other organs.
authors.affiliation: Division of Pediatric Rheumatology, Children's Medical Center, Pediatrics Center of Excellence, Tehran 14194, Iran.
authors.forename: Raheleh
authors.initials: R
authors.lastname: Assari
authors.affiliation: Division of Pediatric Rheumatology, Children's Medical Center, Pediatrics Center of Excellence, Tehran 14194, Iran ; Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Vahid
authors.identifier: 0000-0003-4648-3573
authors.initials: V
authors.lastname: Ziaee
authors.affiliation: Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran ; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Parvaneh
authors.affiliation: Division of Pediatric Rheumatology, Children's Medical Center, Pediatrics Center of Excellence, Tehran 14194, Iran ; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad-Hassan
authors.initials: MH
authors.lastname: Moradinejad