title: Preventive effect of yuzu and hesperidin on left ventricular remodeling and dysfunction in rat permanent left anterior descending coronary artery occlusion model.
abstract: Left ventricular (LV) remodeling, which includes ventricular dilatation and increased interstitial fibrosis after myocardial infarction (MI), is the critical process underlying the progression to heart failure. Therefore, a novel approach for preventing LV remodeling after MI is highly desirable. Yuzu is a citrus plant originating in East Asia, and has a number of cardioprotective properties such as hesperidin. However, no study has proved whether yuzu can prevent LV remodeling. The aim of this study was to determine the effects of yuzu on heart failure (HF) and its potential impact on the LV remodeling process after MI. Our in vivo study using the permanent left anterior descending coronary artery (LAD) occlusion model demonstrate that one week pre-treatment with yuzu or its major metabolite hesperidin before LAD occlusion significantly attenuated cardiac dysfunction, myocyte apoptosis and inflammation. Not only yuzu but also hesperidin inhibited caspase-3 activity, myeloperoxidase expression, α-smooth muscle actin expression, and matrix metalloproteinase-2 activity in a permanent LAD occlusion rat model. To our knowledge, our findings provide the first evidence that yuzu and hesperidin prevent MI-induced ventricular dysfunction and structural remodeling of myocardium.
authors.affiliation: Department of Physiology, School of Medicine, Ajou University, Suwon, Republic of Korea; College of Pharmacy, Ajou University, Suwon, Republic of Korea.
authors.forename: Hye Yon
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Soon Chun Hyang University Gumi Hospital, Gumi, Republic of Korea.
authors.forename: Ji Hun
authors.initials: JH
authors.lastname: Ahn
authors.affiliation: Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, Republic of Korea.
authors.forename: Se Won
authors.initials: SW
authors.lastname: Park
authors.affiliation: College of Pharmacy, Ajou University, Suwon, Republic of Korea; Research Institute of Pharmaceutical Sciences and Technology, Ajou University, Suwon, Republic of Korea.
authors.forename: Yi-Sook
authors.initials: YS
authors.lastname: Jung
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002957:Citrus / Q000737:chemistry*; D054059:Coronary Occlusion / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D004452:Echocardiography; D004789:Enzyme Activation / Q000187:drug effects; D006569:Hesperidin / Q000494:pharmacology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D006569:Hesperidin; D009195:Peroxidase; D020778:Matrix Metalloproteinase 2