title: The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: anemia, biomarkers, and recent therapeutic trial implications.
abstract: The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Update provides discussion on the management recommendations on 3 focused areas: (1) anemia; (2) biomarkers, especially natriuretic peptides; and (3) clinical trials that might change practice in the management of patients with heart failure. First, all patients with heart failure and anemia should be investigated for reversible causes of anemia. Second, patients with chronic stable heart failure should undergo natriuretic peptide testing. Third, considerations should be given to treat selected patients with heart failure and preserved systolic function with a mineralocorticoid receptor antagonist and to treat patients with heart failure and reduced ejection fraction with an angiotensin receptor/neprilysin inhibitor, when the drug is approved. As with updates in previous years, the topics were chosen in response to stakeholder feedback. The 2014 Update includes recommendations, values and preferences, and practical tips to assist the clinicians and health care workers to best manage patients with heart failure.
authors.affiliation: St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: moeg@smh.ca.
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Moe
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Ezekowitz
authors.affiliation: Institut de Cardiologie de Montréal, Montreal, Québec, Canada.
authors.forename: Eileen
authors.initials: E
authors.lastname: O'Meara
authors.affiliation: Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Lepage
authors.affiliation: University of Calgary, Calgary, Alberta, Canada.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Howlett
authors.affiliation: Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
authors.forename: Steve
authors.initials: S
authors.lastname: Fremes
authors.affiliation: St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Abdul
authors.initials: A
authors.lastname: Al-Hesayen
authors.affiliation: University of Waterloo, Waterloo, Ontario, Canada.
authors.forename: George A
authors.initials: GA
authors.lastname: Heckman
authors.affiliation: University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Howard
authors.initials: H
authors.lastname: Abrams
authors.affiliation: Institut de Cardiologie de Montréal, Montreal, Québec, Canada.
authors.forename: Anique
authors.initials: A
authors.lastname: Ducharme
authors.affiliation: St Boniface General Hospital, Cardiac Sciences Program, Winnipeg, Manitoba, Canada.
authors.forename: Estrellita
authors.initials: E
authors.lastname: Estrella-Holder
authors.affiliation: Joseph Brant Memorial Hospital, Burlington, Ontario, Canada; Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Grzeslo
authors.affiliation: Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Harkness
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Koshman
authors.affiliation: University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: McDonald
authors.affiliation: Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: McKelvie
authors.affiliation: QE II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Rajda
authors.affiliation: University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.affiliation: Royal Jubilee Hospital, Victoria, British Columbia, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Swiggum
authors.affiliation: University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Sean
authors.initials: S
authors.lastname: Virani
authors.affiliation: St Boniface General Hospital, Cardiac Sciences Program, Winnipeg, Manitoba, Canada.
authors.forename: Shelley
authors.initials: S
authors.lastname: Zieroth
authors.affiliation: University of Western Ontario, London, Ontario, Canada.
authors.forename: J Malcolm O
authors.initials: JM
authors.lastname: Arnold
authors.affiliation: Penticton, British Columbia, Canada.
authors.forename: Tom
authors.initials: T
authors.lastname: Ashton
authors.affiliation: Université de Moncton, Moncton, New Brunswick, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: D'Astous
authors.affiliation: Edmonton Cardiology Consultants, Edmonton, Alberta, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Chan
authors.affiliation: Cape Breton Regional Hospital, Sydney, Nova Scotia, Canada.
authors.forename: Sabe
authors.initials: S
authors.lastname: De
authors.affiliation: St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Dorian
authors.affiliation: McGill University, Montreal, Québec, Canada.
authors.forename: Nadia
authors.initials: N
authors.lastname: Giannetti
authors.affiliation: Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Haissam
authors.initials: H
authors.lastname: Haddad
authors.affiliation: University of Calgary, Calgary, Alberta, Canada.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Isaac
authors.affiliation: Centre Hospitalier Régional de Lanaudière, Joliette, Québec and Université Laval, Québec, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Kouz
authors.affiliation: Hôpital Laval, Sainte-Foy, Québec, Canada.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Leblanc
authors.affiliation: Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Liu
authors.affiliation: University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Ross
authors.affiliation: Health Sciences Centre, St John's, Newfoundland, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Sussex
authors.affiliation: Institut de Cardiologie de Montréal, Montreal, Québec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: White
mesh_terms: D000740:Anemia / Q000097:blood / Q000517:prevention & control*; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D002170:Canada; D002309:Cardiology / Q000458:organization & administration*; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D015260:Neprilysin / Q000037:antagonists & inhibitors; D012955:Societies, Medical / Q000458:organization & administration*
chemical_list: D057911:Angiotensin Receptor Antagonists; D015415:Biomarkers; D000451:Mineralocorticoid Receptor Antagonists; D015260:Neprilysin