title: Hematologic effects and complications of snake envenoming.
abstract: Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hematologic abnormalities are an anticoagulant coagulopathy and thrombotic microangiopathy. Venom-induced consumption coagulopathy is a venom-induced activation of the clotting pathway by procoagulant toxins, resulting in clotting factor consumption and coagulopathy. The type of procoagulant toxin differs between snakes and can activate prothrombin, factor X, and factor V or consume fibrinogen. The most useful investigation in VICC is a prothrombin time/international normalized ratio. The d-dimer may assist in early diagnosis, but fibrinogen levels often add little in the clinical setting. Bedside investigations would be ideal, but point-of-care testing international normalized ratio and whole blood clotting tests have been shown to be unreliable in VICC. The major complication of VICC is hemorrhage, including intracranial hemorrhage which is often fatal. The role of antivenom in VICC is controversial and may only be beneficial for some types of snakes including Echis spp where the duration of abnormal clotting is reduced from more than a week to 24 to 48 hours. In contrast, antivenom does not appear to speed the recovery of VICC in Australian snake envenoming. Other treatments for VICC include factor replacement, observation and prevention of trauma, and heparin. An Australian study showed that fresh-frozen plasma speeds recovery of VICC, but early use may increase consumption. There is no evidence to support heparin.
authors.affiliation: Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, Australia; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia. Electronic address: Ingrid.berling@gmail.com.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Berling
authors.affiliation: Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, Australia; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Isbister
mesh_terms: D000818:Animals; D000997:Antivenins / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D017815:Elapidae; D004789:Enzyme Activation / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000628:therapy; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000628:therapy; D010949:Plasma; D011517:Prothrombin Time; D012909:Snake Bites / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D012910:Snake Venoms / Q000494:pharmacology* / Q000633:toxicity; D057049:Thrombotic Microangiopathies / Q000209:etiology; D017819:Viperidae; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D000997:Antivenins; D001779:Blood Coagulation Factors; D012910:Snake Venoms; D005340:Fibrinogen; D006493:Heparin
keywords: Coagulopathy; Envenoming; Snake; Venom