title: Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats.
abstract: Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against ischemic cerebral injury. To validate this hypothesis, rats were intraperitoneally administered with 0.66 mL/kg Setarud for 30 minutes after middle cerebral artery occlusion. Triphenyltetrazolium chloride staining showed that Setarud could reduce cerebral infarct volume of rats subjected to cerebral ischemia. Transmission electron microscopy and hematoxylin-eosin staining results showed that Setarud could alleviate the degenerative changes in cortical neurons of rats with cerebral ischemia. The inclined plate test and prehensile test showed that Setarud could significantly improve the motor function of rats with cerebral ischemia. These findings suggest that Setarud shows neuroprotective effects against ischemic brain injury.
authors.affiliation: Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Vafaee
authors.affiliation: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Nasser
authors.initials: N
authors.lastname: Zangiabadi
authors.affiliation: Member of Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Fatemeh Mehdi
authors.initials: FM
authors.lastname: Pour
authors.affiliation: Member of Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Dehghanian
authors.affiliation: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Asadi-Shekaari
authors.affiliation: Member of Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Hossein Karimi
authors.initials: HK
authors.lastname: Afshar
keywords: antioxidant; brain injury; cerebral infarct; cortex; immunomodulatory drug; inclined plate test; neural regeneration; neuroprotection; prehensile test; stroke