title: Red meat intake and risk of non-Hodgkin lymphoma: a meta-analysis.
abstract: BACKGROUND
  While the incidence of non-Hodgkins lymphoma (NHL) has been rising worldwide, the reasons remain undefined. Recent research has focused on effect of red andf processed meat intake as a risk factor, but with inconclusive results. We therefore conducted a meta-analysis of data published to date, to ascertain the overall association between intake and NHL.
  
  
  METHODS
  A published literature search was performed through Pubmed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using Chi-square and I2 statistics. Dissemination bias was evaluated by funnel plot analysis.We performed a formal meta-analysis using summary measures from these studies.
  
  
  RESULTS
  In total, 11 published studies were included in the final analysis. The combined analysis revealed that there was significant association between the red meat and NHL risk (OR=1.10, 95%CI: 1.02 to 1.19, p=0.01). Additionally, there was showed significance association between processed red meat and NHL risk (OR=1.17, 95%CI: 1.06 to 1.29, p=0.001). In subgroup analysis, a statistical significant association was noted between diffuse large B-cell lymphoma (DLBCL) (OR=1.20, 95%CI: 1.04 to 2.37, P=0.01) and red meat intake.
  
  
  CONCLUSIONS
  In this meta-Analysis, there was evidence for association between consumption of red meat, or processed meat and risk of NHL, particularly with the DLBCL subtype in the red meat case.
authors.affiliation: Department of Biostatistics and Epidemiology, Research Center of Prevention and Epidemiology of Non-Communicable Disease, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran E-mail : Epidemiology2012@gmail.com.
authors.forename: Hosein
authors.initials: H
authors.lastname: Fallahzadeh
authors.forename: Maria
authors.initials: M
authors.lastname: Cheraghi
authors.forename: Neda
authors.initials: N
authors.lastname: Amoori
authors.forename: Mehrangiz
authors.initials: M
authors.lastname: Alaf
mesh_terms: D000818:Animals; D002417:Cattle; D005247:Feeding Behavior; D005511:Food Handling; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology*; D008224:Lymphoma, Follicular / Q000453:epidemiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D008460:Meat; D008461:Meat Products; D016017:Odds Ratio; D012307:Risk Factors; D013552:Swine