title: Optical coherence tomography and autofluorescence imaging of human tonsil.
abstract: For the first time, we present co-registered autofluorescence imaging and optical coherence tomography (AF/OCT) of excised human palatine tonsils to evaluate the capabilities of OCT to visualize tonsil tissue components. Despite limited penetration depth, OCT can provide detailed structural information about tonsil tissue with much higher resolution than that of computed tomography, magnetic resonance imaging, and Ultrasound. Different tonsil tissue components such as epithelium, dense connective tissue, lymphoid nodules, and crypts can be visualized by OCT. The co-registered AF imaging can provide matching biochemical information. AF/OCT scans may provide a non-invasive tool for detecting tonsillar cancers and for studying the natural history of their development.
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Hamid
authors.initials: H
authors.lastname: Pahlevaninezhad
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Anthony M D
authors.initials: AM
authors.lastname: Lee
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Miriam
authors.initials: M
authors.lastname: Rosin
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sun
authors.affiliation: Department of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Lewei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Hakimi
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Calum
authors.initials: C
authors.lastname: MacAulay
authors.affiliation: Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
authors.forename: Pierre M
authors.initials: PM
authors.lastname: Lane
mesh_terms: D003238:Connective Tissue; D004848:Epithelium; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology; D014066:Palatine Tonsil / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods*