title: ABCB1 gene polymorphisms and violent suicide attempt among survivors.
abstract: BACKGROUND
  Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for P-gp. Thus, this study examined, for the first time, whether these ABCB1 SNPs were associated with the use of violent means among survivors of a suicide attempt.
  
  
  METHODS
  Suicide attempters (n = 578, 87.4% women; of whom 16.6% committed a violent intent) were genotyped for exonic SNPs in the ABCB1 (C1236T, G2677T/A, C3435T). The relations of the three genotypes and of the TTT haplotype with the use of a violent suicide method were evaluated separately. The impact of confounds on these variables was controlled.
  
  
  RESULTS
  A higher frequency (p = 0.02) of suicide attempters using violent methods was found among those carrying the ABCB1 haplotype (1236TT-2677TT-3435TT). Since gender and number of previous suicide attempts were identified as confounds, the relation was tested in the subset of women who were first-time attempters or second- and more-time attempters. The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time (OR = 3.6; CI95%: 1.08-12.09; p = 0.04).
  
  
  CONCLUSIONS
  The ABCB1 haplotype (1236TT-2677TT-3435TT) was related to the use of a violent suicide attempt method. Genotyping for these three ABCB1 SNPs may be helpful to detect people at risk of first suicide intents using violent methods.
authors.affiliation: CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain. Electronic address: elledo@unex.es.
authors.forename: E
authors.initials: E
authors.lastname: Peñas-Lledó
authors.affiliation: CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Acute Care Department, Pole Urgence, Montpellier, France; Inserm, U1061 Montpellier, Université Montpellier I, Montpellier, F-34000, France; FondaMental Foundation, France.
authors.forename: S
authors.initials: S
authors.lastname: Guillaume
authors.affiliation: CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Delgado
authors.affiliation: CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain.
authors.forename: M E G
authors.initials: ME
authors.lastname: Naranjo
authors.affiliation: Inserm, U1061 Montpellier, Université Montpellier I, Montpellier, F-34000, France; FondaMental Foundation, France.
authors.forename: I
authors.initials: I
authors.lastname: Jaussent
authors.affiliation: CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain; CIBERSAM, Instituto de Salud Carlos III, Spain.
authors.forename: A
authors.initials: A
authors.lastname: LLerena
authors.affiliation: CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Acute Care Department, Pole Urgence, Montpellier, France; Inserm, U1061 Montpellier, Université Montpellier I, Montpellier, F-34000, France; FondaMental Foundation, France.
authors.forename: P
authors.initials: P
authors.lastname: Courtet
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology; D017741:Survivors / Q000523:psychology; D014754:Violence / Q000523:psychology; D055815:Young Adult
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: ABCB1; Suicide attempt; Violent suicide methods