title: Mismatch negativity (MMN) deficiency: a break-through biomarker in predicting psychosis onset.
abstract: Currently, the mismatch negativity (MMN) deficit is one of the most robust and replicable findings in schizophrenia, reflecting cognitive and functional decline, psychosocial and socio-occupational impairment, and executive dysfunction in these patients. An important break-through has very recently taken place here in the prediction of conversion to psychosis when the MMN in particular to change in tone duration was recorded in clinically at risk-mental state (ARMS) individuals. Attenuations in the MMN in these patients may be very useful in helping clinicians determine who are most likely to develop a psychotic disorder, as we will review in the present article.
authors.affiliation: Department of Psychology, University of Tartu, Tartu, Estonia; Center of Functionally Integrative Neuroscience (CFIN), University of Århus, Århus, Denmark; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
authors.forename: Risto
authors.initials: R
authors.lastname: Näätänen
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan. Electronic address: tetsuya3@fmu.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiga
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Asano
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Yabe
mesh_terms: D001921:Brain / Q000503:physiopathology*; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000473:pathology*
keywords: At-risk mental state (ARMS); Event related potential (ERP); Mismatch negativity (MMN); Prediction; Psychosis; Schizophrenia; Ultra-high risk