title: Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models.
abstract: OBJECTIVE
  To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models.
  
  
  METHODS
  Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ). RV diastolic functional alteration of rat models was studied by the tricuspid flow Doppler (Ep, Ap, and Ep/Ap) and tissue Doppler imaging (TDI) (Em, Am, and Em/Am) of the lateral tricuspid annulus. RV structural alteration of rat models was studied by standard 2D and M-mode echocardiography.
  
  
  RESULTS
  Compared with-the control group rats, at the 12th week after STZ injection, the rats of the diabetic group developed RV diastolic dysfunction, lower Em, and lower ratios (Ep/Ap, Em/Am). At the end of the experiment, at the 16th week after STZ injection, the rats of the diabetic group showed further decreased Ep, Em, and ratios (Ep/Ap, Em/Am) and significantly higher RV diameters compared with the control group rats.
  
  
  CONCLUSIONS
  We demonstrated that the diastolic dysfunction of the RV was the earliest complication observed in type 2 diabetic rat models, using TDI and tricuspid flow Doppler. TDI showed a high sensitivity in detecting changes of RV diastolic function.
authors.affiliation: Department of Geriatrics, Shanghai Jiaotong University Affiliated Sixth people's Hospital, Shanghai, P.R. China. nning-my@163.com
authors.forename: Ya
authors.initials: Y
authors.lastname: Miao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhongi
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology; D016022:Case-Control Studies; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016278:Ventricular Function, Right / Q000502:physiology
chemical_list: D001786:Blood Glucose