title: [The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury].
abstract: The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin (65 mg/kg) was administered per os 1 h before modeling of ischemia-reperfusion. Studies were carried 1 h after reperfusion. It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion.
authors.affiliation: Grodno State Medical University.
authors.forename: N Ye
authors.initials: NY
authors.lastname: Maksimovich
authors.affiliation: Grodno State Medical University.
authors.forename: I K
authors.initials: IK
authors.lastname: Dremza
authors.affiliation: Grodno State Medical University.
authors.forename: E I
authors.initials: EI
authors.lastname: Troian
authors.affiliation: Grodno State Medical University.
authors.forename: Ya N
authors.initials: YN
authors.lastname: Maksimovich
authors.affiliation: Grodno State Medical University.
authors.forename: A N
authors.initials: AN
authors.lastname: Borodinskiĭ
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D019344:Lactic Acid / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D010101:Oxygen Consumption / Q000187:drug effects; D019289:Pyruvic Acid / Q000378:metabolism; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019344:Lactic Acid; D019289:Pyruvic Acid; D011794:Quercetin; C003377:taxifolin
keywords: brain; dihydroquercetin; mitochondrial respiration; oxidative stress; reperfusion