title: Reduced E-Cadherin expression is a prognostic biomarker of non-small cell lung cancer: a meta-analysis based on 2395 subjects.
abstract: OBJECTIVE
  Previous studies related to the prognostic value of E-Cadherin expression on non-small cell lung cancer (NSCLC) were inconsistent. The present study aimed to evaluate the relation between E-Cadherin expression and the prognosis of NSCLC.
  
  
  METHODS
  We performed a meta-analysis based on 14 studies including 2395 NSCLC patients. Literature retrieval, data extraction, and meta-analyses were performed according to the Revman 5.0 guidelines. We utilized the fixed-effect model to pool the HR according to the test of heterogeneity in the meta-analysis.
  
  
  RESULTS
  A total of 14 eligible studies including 2395 NSCLC patients were analyzed. In total, 51.2% of the patients were considered as having reduced expression of E-Cadherin according to the authors' cutoff. The pooled hazard ratio (HR) of reduced expression of E-Cadherin for overall survival (OS) was 1.19 (95% CI: 1.01 to 1.40, P=0.04), showing a worse survival when E-Cadherin expression is decreased.
  
  
  CONCLUSIONS
  Patients with reduced expression of E-cadherin have a poorer OS compared with those with normal or high expression of E-cadherin.
authors.affiliation: Department of Respiratory, Shanghai Chest Hospital, Shanghai Jiao Tong University Shanghai 200030, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Respiratory, Shanghai Chest Hospital, Shanghai Jiao Tong University Shanghai 200030, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Respiratory, Shanghai Chest Hospital, Shanghai Jiao Tong University Shanghai 200030, P.R. China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Jiang
authors.affiliation: Shanghai Cancer Institute Shanghai 200032, P.R. China.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Qin
authors.affiliation: Department of Respiration, General Hospital of Jinan Military Command No. 25 Shifan Road, Jinan 250031, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
keywords: E-cadherin; non-small cell lung cancer; prognosis