title: Transport properties in aqueous ethambutol dihydrochloride.
abstract: Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15K. From these experimental results and by using the appropriate models (Stokes-Einstein and Hartley), the hydrodynamic radii Rh, the diffusion coefficient at infinitesimal concentration D(0) and the thermodynamic factors, FT, have been estimated, permitting us to have a better understanding of the transport behavior of ethambutol dihydrochloride in solution. Elucidation of lack of any possible drug-drug interactions in these systems was obtained by complementary (1)H nuclear magnetic resonance (NMR) spectroscopy data.
authors.affiliation: Department of Chemistry, Coimbra Chemistry Centre, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: luisve@gmail.com.
authors.forename: Luís M P
authors.initials: LM
authors.lastname: Veríssimo
authors.affiliation: Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra, Portugal. Electronic address: acabral@ff.uc.pt.
authors.forename: Ana M T D P V
authors.initials: AM
authors.lastname: Cabral
authors.affiliation: Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra, Portugal. Electronic address: fveiga@ci.uc.pt.
authors.forename: Francisco J B
authors.initials: FJ
authors.lastname: Veiga
authors.affiliation: Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra, Portugal. Electronic address: sarafgalmeida@gmail.com.
authors.forename: Sara F G
authors.initials: SF
authors.lastname: Almeida
authors.affiliation: Department of Chemistry, Coimbra Chemistry Centre, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: mlramos@ci.uc.pt.
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Ramos
authors.affiliation: Department of Chemistry, Coimbra Chemistry Centre, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: burrows@ci.uc.pt.
authors.forename: Hugh D
authors.initials: HD
authors.lastname: Burrows
authors.affiliation: U.D Química Física, Facultad de Farmacia, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: miguel.esteso@uah.es.
authors.forename: M A
authors.initials: MA
authors.lastname: Esteso
authors.affiliation: Department of Chemistry, Coimbra Chemistry Centre, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: anacfrib@ci.uc.pt.
authors.forename: Ana C F
authors.initials: AC
authors.lastname: Ribeiro
mesh_terms: D001692:Biological Transport; D004058:Diffusion; D004347:Drug Interactions; D004977:Ethambutol / Q000737:chemistry*; D057446:Hydrodynamics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D019999:Pharmaceutical Solutions; D013816:Thermodynamics; D014783:Viscosity; D014867:Water
chemical_list: D019999:Pharmaceutical Solutions; D014867:Water; D004977:Ethambutol
keywords: (1)H NMR spectroscopy; Diffusion coefficients; Ethambutol dihydrochloride; Solutions; Transport properties; Tuberculosis