title: Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma.
abstract: OBJECTIVE
  To determine the efficacy of endoscopic surgery in combination with long-acting somatostatin analogues (SSAs) in treating patients with growth hormone (GH)-secreting pituitary tumor.
  
  
  METHODS
  We performed retrospective analysis of 133 patients with GH producing pituitary adenoma who underwent pure endoscopic transsphenoidal surgery in our center from January 2007 to July 2012. Patients were followed up for a range of 3-48 months. The radiological remission, biochemical remission and complication were evaluated.
  
  
  RESULTS
  A total of 110 (82.7%) patients achieved radiological complete resection, 11 (8.2%) subtotal resection, and 12 (9.0%) partial resection. Eighty-eight (66.2%) patients showed nadir GH level less than 1 ng/mL after oral glucose administration. No mortality or severe disability was observed during follow up. Preoperative long-acting SSA successfully improved left ventricle ejection fraction (LVEF) and blood glucose in three patients who subsequently underwent success operation. Long-acting SSA (20 mg every 30 days) achieved biochemical remission in 19 out 23 (82.6%) patients who showed persistent high GH level after surgery.
  
  
  CONCLUSIONS
  Endoscopic transsphenoidal surgery can biochemically cure the majority of GH producing pituitary adenoma. Post-operative use of SSA can improve biochemical remission.
authors.affiliation: Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Fuyu
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Endocrinology, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Ba
authors.affiliation: Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
authors.forename: Bainan
authors.initials: B
authors.lastname: Xu
keywords: Endoscopic transsphenoidal surgery; GH producing pituitary adenoma; Somatostatin analogue