title: Seizures as a Potential Complication of Treatment With Simeprevir and Sofosbuvir.
abstract: Newer direct-acting antiviral agents have revolutionized the medical management of chronic hepatitis C. In addition to being extremely efficacious, they report very mild adverse drug reactions from experience in clinical trials. However, because they are relatively new on the horizon, postmarketing surveillance studies refining the safety profile are not yet available. We present a case of seizures as a potential side effect of antiviral therapy with sofosbuvir and simeprevir.
authors.affiliation: 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR; and 2Department of Clinical Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Syal
authors.forename: Seth D
authors.initials: SD
authors.lastname: Heldenbrand
authors.forename: Andres
authors.initials: A
authors.lastname: Duarte-Rojo
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*; D000069616:Simeprevir / Q000009:adverse effects*; D000069474:Sofosbuvir / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D000069616:Simeprevir; D000069474:Sofosbuvir