title: Microdosimetry spectra and relative biological effectiveness of 15 and 30MeV proton beams.
abstract: The relative biological effectiveness (RBE) of high-energy protons has been well investigated, but estimates of RBE for lower-energy (<40MeV) protons are scarce. In the present work, measurements were made of the lineal energy spectra using a home-made miniature tissue-equivalent proportional counter for 15 and 30MeV protons from the TR 30/15 cyclotron. Monte Carlo simulations were made for the same spectra using the FLUKA code. These spectra were coupled to several biological models to evaluate the RBE for various biological endpoints.
authors.affiliation: Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Kweishan 333, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Pan
authors.affiliation: Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Kweishan 333, Taiwan.
authors.forename: Y W
authors.initials: YW
authors.lastname: Huang
authors.affiliation: Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Kweishan 333, Taiwan.
authors.forename: K H
authors.initials: KH
authors.lastname: Cheng
authors.affiliation: Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Kweishan 333, Taiwan.
authors.forename: T C
authors.initials: TC
authors.lastname: Chao
authors.affiliation: Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Kweishan 333, Taiwan; Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital at Linkou, Kweishan 333, Taiwan. Electronic address: cjtung@mail.cgu.edu.tw.
authors.forename: C J
authors.initials: CJ
authors.lastname: Tung
mesh_terms: D017357:Cyclotrons; D053903:DNA Breaks, Double-Stranded; D006801:Humans; D018499:Linear Energy Transfer; D008954:Models, Biological; D009010:Monte Carlo Method; D061766:Proton Therapy; D011874:Radiometry / Q000295:instrumentation* / Q000706:statistics & numerical data; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data; D011882:Radiotherapy, High-Energy / Q000706:statistics & numerical data; D012062:Relative Biological Effectiveness; D011522:Protons
chemical_list: D011522:Protons
keywords: FLUKA code; Lineal energy; Relative biological effectiveness; TR 30/15 cyclotron; Tissue equivalent proportional counter