title: A 3D model of thrombus formation in a stent-graft after implantation in the abdominal aorta.
abstract: Here we present a 3D kinetic model of thrombus formation in an endovascular prosthesis after implantation in an abdominal aorta with an aneurysm. The computational fluid dynamic technique (CFD) was used to determine the process of thrombus formation and growth in the stent-graft on the basis of the medical data from computed tomography angiography and Doppler ultrasound examination of 10 patients. The Quemada model was used to describe rheological properties of blood. Results of the CFD simulations were validated based on actual data from patients with diagnosed thrombi in aortic implants. The results show that the elaborated CFD model correctly predicted thrombus formation, shape and deposition site in an endovascular prosthesis. The developed CFD model of thrombus growth can be applied to predict the risk of thrombus formation in stent-grafts and assist in selection of geometry of the endovascular prosthesis to reduce possible complications after stent-graft implantation using only basic medical data.
authors.affiliation: Lodz University of Technology, Faculty of Process and Environmental Engineering, Department of Heat and Mass Transfer, Poland. Electronic address: andrzej.polanczyk@gmail.com.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Polanczyk
authors.affiliation: Lodz University of Technology, Faculty of Process and Environmental Engineering, Department of Heat and Mass Transfer, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Podyma
authors.affiliation: Department of Radiology and Diagnostic Imaging, Medical University of Lodz, Poland.
authors.forename: Ludomir
authors.initials: L
authors.lastname: Stefanczyk
authors.affiliation: Department of Radiology and Diagnostic Imaging, Medical University of Lodz, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szubert
authors.affiliation: Lodz University of Technology, Faculty of Process and Environmental Engineering, Department of Heat and Mass Transfer, Poland.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Zbicinski
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging; D019917:Blood Vessel Prosthesis Implantation; D006801:Humans; D057446:Hydrodynamics; D007700:Kinetics; D008875:Middle Aged; D008955:Models, Cardiovascular; D011859:Radiography; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000503:physiopathology*; D019737:Transplants
keywords: Blood coagulation; CFD simulations; Endovascular prosthesis; Thrombus development