title: Role of p66Shc gene in human longevity.
abstract: The p66Shc gene has emerged as a novel gerontogene affecting health and life during aging. In murine models of aging,a genetic deficiency of the p66Shc gene,which encodes a phosphotyrosine signal adapter protein,extends life span by 30%. p66Shc is a crucial regulator of reactive oxygen species levels and is involved in age-related dysfunctions. UP to now,oxidative stress has been recognized to be involved in human diseases such as high cholesterol,diabetes,and cardiovascular diseases. Further study on the role of p66Shc will facilitate the research of novel disease-targetted drugs and slow down or cure age-related pathologies.
authors.affiliation: Department of Neurosurgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Ren-Zhi
authors.initials: RZ
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D006801:Humans; D008136:Longevity / Q000235:genetics*; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D055765:Shc Signaling Adaptor Proteins / Q000235:genetics*
chemical_list: D017382:Reactive Oxygen Species; D055765:Shc Signaling Adaptor Proteins