title: Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology.
abstract: Recent pertussis resurgence represents a major public health concern. Currently, there are no effective treatments for critical pertussis in infants. Recent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the treatment of infectious diseases. We used the murine Bordetella pertussis model to test the hypothesis that treatment with S1PR agonist AAL-R reduces pulmonary inflammation during infection. AAL-R treatment resulted in reduced expression of inflammatory cytokines and chemokines and attenuated lung pathology in infected mice. These results demonstrate a role for sphingosine-1-phosphate (S1P) signaling in B. pertussis-mediated pathology and highlight the possibility of host-targeted therapy for pertussis.
authors.affiliation: Department of Microbiology and Immunology, University of Maryland Medical School, Baltimore.
authors.forename: Ciaran
authors.initials: C
authors.lastname: Skerry
authors.affiliation: Department of Microbiology and Immunology, University of Maryland Medical School, Baltimore.
authors.forename: Karen
authors.initials: K
authors.lastname: Scanlon
authors.affiliation: Departments of Chemical Physiology and Immunology, The Scripps Research Institute, La Jolla, California.
authors.forename: Hugh
authors.initials: H
authors.lastname: Rosen
authors.affiliation: Department of Microbiology and Immunology, University of Maryland Medical School, Baltimore.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Carbonetti
mesh_terms: D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D004195:Disease Models, Animal; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008810:Mice, Inbred C57BL; D018410:Pneumonia, Bacterial / Q000382:microbiology / Q000473:pathology*; D049349:Receptors, Lysosphingolipid / Q000819:agonists*
chemical_list: D049349:Receptors, Lysosphingolipid
keywords: AAL-R; bordetella; host-directed; pertussis; sphingosine; sphingosine-1-phosphate