title: Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study.
abstract: Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician's visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors. Results. At baseline, the mean age of OA cases was 61 years and 60.5% were women. Over 12 years of mean follow-up, the incidence rate (95% CI) of diabetes was 11.2 (10.90-11.50) per 1000 person years. Adjusted RRs (95% CI) for diabetes were 1.27 (1.15-1.41), 1.21 (1.08-1.35), 1.16 (1.04-1.28), and 0.99 (0.86-1.14) for younger women (age 20-64 years), older women (age ≥ 65 years), younger men, and older men, respectively. Conclusion. Younger adults and older women with OA have increased risks of developing diabetes compared to their age-sex matched non-OA counterparts. Further studies are needed to confirm these results and to elucidate the potential mechanisms.
authors.affiliation: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 ; Department of Applied Statistics, East West University, Aftabnagar, Dhaka 1212, Bangladesh.
authors.forename: M Mushfiqur
authors.initials: MM
authors.lastname: Rahman
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1M9 ; Arthritis Research Centre of Canada, 5591 No. 3 Road, Richmond, BC, Canada V6X 2C7.
authors.forename: Jolanda
authors.initials: J
authors.lastname: Cibere
authors.affiliation: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 ; Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada V6Z 1Y6.
authors.forename: Aslam H
authors.initials: AH
authors.lastname: Anis
authors.affiliation: Arthritis Research Centre of Canada, 5591 No. 3 Road, Richmond, BC, Canada V6X 2C7 ; Health Sciences, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.
authors.forename: Charlie H
authors.initials: CH
authors.lastname: Goldsmith
authors.affiliation: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 ; Arthritis Research Centre of Canada, 5591 No. 3 Road, Richmond, BC, Canada V6X 2C7.
authors.forename: Jacek A
authors.initials: JA
authors.lastname: Kopec