title: Inflammatory Papillitis in Uveitis: Response to Treatment and Use of Optic Nerve Optical Coherence Tomography for Monitoring.
abstract: OBJECTIVE
  To describe the clinical course of uveitis-associated inflammatory papillitis and evaluate the utility and reproducibility of optic nerve spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Data on 22 eyes of 14 patients with uveitis-related papillitis and optic nerve imaging were reviewed. SD-OCT measure reproducibility was determined and parameters were compared in active vs. inactive uveitis.
  
  
  RESULTS
  Papillitis resolution lagged behind uveitis resolution in three patients. For SD-OCT measures, the intraclass correlation coefficients were 99.1-100% and 86.9-100% for intraobserver and interobserver reproducibility, respectively. All SD-OCT optic nerve measures except inferior and nasal peripapillary retinal thicknesses were significantly higher in active vs. inactive uveitis after correction for multiple hypotheses testing. Mean optic nerve central thickness decreased from 545.1 to 362.9 µm (p = 0.01).
  
  
  CONCLUSIONS
  Resolution of inflammatory papillitis can lag behind resolution of uveitis. SD-OCT assessment of papillitis is reproducible and correlates with presence vs. resolution of uveitis.
authors.affiliation: a Department of Ophthalmology , Uveitis and Retina Services, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , Massachusetts , USA and.|b Department of Ophthalmology , Hanyang University College of Medicine , Seoul , Korea.
authors.forename: Heeyoon
authors.initials: H
authors.lastname: Cho
authors.affiliation: a Department of Ophthalmology , Uveitis and Retina Services, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , Massachusetts , USA and.
authors.forename: Parvathy
authors.initials: P
authors.lastname: Pillai
authors.affiliation: a Department of Ophthalmology , Uveitis and Retina Services, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , Massachusetts , USA and.
authors.forename: Laura
authors.initials: L
authors.lastname: Nicholson
authors.affiliation: a Department of Ophthalmology , Uveitis and Retina Services, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , Massachusetts , USA and.
authors.forename: Lucia
authors.initials: L
authors.lastname: Sobrin
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D016903:Drug Monitoring; D005260:Female; D005477:Fluprednisolone / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000069285:Infliximab / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D015588:Observer Variation; D009883:Ophthalmic Solutions; D009898:Optic Disk / Q000098:blood supply / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000627:therapeutic use; D014605:Uveitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D005477:Fluprednisolone; D000069285:Infliximab; D014222:Triamcinolone Acetonide; C015808:difluprednate; D008727:Methotrexate
keywords: Optical coherence tomography; optic nerve head; papillitis; reproducibility; uveitis