title: Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure.
abstract: We investigated differences in outcomes between 68 children hospitalized with macrolide-sensitive Mycoplasma pneumoniae pneumonia (MSMP group) and 25 children hospitalized with macrolide-resistant M. pneumoniae pneumonia (MRMP group). In the MRMP group, 19 children received macrolides and clinical failure occurred in six of which five had pneumonia progression during therapy.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Kai-Ning
authors.initials: KN
authors.lastname: Cheong
authors.affiliation: Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Susan S
authors.initials: SS
authors.lastname: Chiu
authors.affiliation: Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Betsy Wai-Ka
authors.initials: BW
authors.lastname: Chan
authors.affiliation: Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Kelvin Kai-Wang
authors.initials: KK
authors.lastname: To
authors.affiliation: Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Eunice Lai-Yin
authors.initials: EL
authors.lastname: Chan
authors.affiliation: Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China. Electronic address: plho@hkucc.hku.hk.
authors.forename: Pak-Leung
authors.initials: PL
authors.lastname: Ho
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D018942:Macrolides / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides
keywords: atypical pneumonia; empyema; macrolides