title: Changing interdigestive migrating motor complex in rats under acute liver injury.
abstract: Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and characteristics of MMC in rats with acute liver injury. Acute liver injury was created by d-galactosamine, and we recorded the interdigestive MMC using a multichannel physiological recorder and compared the indexes of interdigestive MMC. Compared with normal controls, antral MMC Phase I duration was significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The duodenal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The jejunal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury compared with normal controls. Compared with the normal controls, rats with acute liver injury had a significantly prolonged interdigestive MMC cycle, related mainly to longer MMC Phases I and IV, shortened MMC Phase III, and MMC Phase II characterized by increased migrating clustered contractions, which were probably major contributors to the gastrointestinal motility disorders.
authors.affiliation: Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China ; Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
authors.forename: Mei
authors.identifier: 0000-0003-2740-6281
authors.initials: M
authors.lastname: Liu
authors.affiliation: Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Su-Jun
authors.initials: SJ
authors.lastname: Zheng
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Duan
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000503:physiopathology*; D004063:Digestion; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology; D005688:Galactosamine / Q000633:toxicity; D005769:Gastrointestinal Motility; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D016065:Myoelectric Complex, Migrating; D051381:Rats
chemical_list: D005688:Galactosamine