title: Differences between information in registries and articles did not influence publication acceptance.
abstract: OBJECTIVE
  To assess whether journals are more likely to reject manuscripts with differences between information in registries and articles. We compared differences by sponsorship and assessed whether selective reporting favored publication of significant outcomes.
  
  
  METHODS
  Drug trials submitted to eight journals (January 2010-April 2012) were included. Publication status, primary outcomes, enrollment, and sponsorship were extracted. Primary outcomes and enrollment in registries and registration timing were reviewed. Prospective registration included registration before study start. Consistency between registered and reported information was evaluated.
  
  
  RESULTS
  For 226 submitted manuscripts, primary outcomes were specified in both article and registry. Sixty six of 226 (29.2%) had primary outcome differences; 14 of 66 manuscripts with differences (21.2%) and 46 of 160 without differences (28.8%) were accepted. Fifty manuscripts (22.4%) had sample size differences; 10 of 50 with differences (20.0%) and 49 of 173 without differences (28.3%) were accepted. Industry-sponsored trials had less differences and were more often prospectively registered. After adjustment for sponsorship, differences and/or retrospective registration were not associated with decreased chance of acceptance (odds ratio 0.56; 95% confidence interval: 0.27, 1.13). Primary outcome differences favored significant outcomes in 49% of manuscripts.
  
  
  CONCLUSIONS
  Differences between registered and reported information are not decisive for rejection. Editors should assess consistency between registries and articles to address selective reporting.
authors.affiliation: Clinical Research Centre Nijmegen, Department of Pharmacology-Toxicology, Radboud University Medical Center, Philips van Leydenlaan 15, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Marlies.vanLent@radboudumc.nl.
authors.forename: Marlies
authors.initials: M
authors.lastname: van Lent
authors.affiliation: Department for Health Evidence, Radboud University Medical Center, Geert Grooteplein noord 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Joanna
authors.initials: J
authors.lastname: IntHout
authors.affiliation: Clinical Research Centre Nijmegen, Department of Pharmacology-Toxicology, Radboud University Medical Center, Philips van Leydenlaan 15, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Global Medical Affairs, Teva Pharmaceuticals, Piet Heinkade 107, 1019 GM Amsterdam, The Netherlands.
authors.forename: Henk Jan
authors.initials: HJ
authors.lastname: Out
mesh_terms: D015706:Bibliometrics; D002986:Clinical Trials as Topic; D003657:Decision Making; D004345:Drug Industry; D035081:Editorial Policies; D006801:Humans; D017712:Peer Review, Research; D010506:Periodicals as Topic / Q000706:statistics & numerical data*; D011643:Publishing / Q000706:statistics & numerical data*; D012042:Registries
keywords: Drug trials; Editorial decision making; Industry sponsorship; Peer review; Selective reporting; Trial registration