title: [Sexually transmitted coinfections. HIV coinfections].
abstract: Coinfections of sexually transmitted infections are frequent due to the same transmission routes which may facilitate the transmission of other sexually transmitted infections. Sexually transmitted coinfections are associated with atypical and generally more severe clinical features, more complications, resistency to treatment, unfavourable outcome, and worse prognosis. Sexually transmitted infections may increase the likelihood of acquiring and transmission of HIV infection. The authors summarize the most important characteristics of sexually transmitted infections (such as HIV and hepatitis B virus, HIV and hepatitis C virus, HIV and syphilis, HIV and gonorrhoeae, HIV and chlamydia coinfections). These infections are more frequent in HIV infected patients than in the normal population. The shared transmission routes, impairment of the immune response, elevated cytokine levels and the associated inflammatory milieu produce local tissue damage, breaches in mucosal epithelium, which increases the risk of human immunodeficiency virus infection. Regular screening for sexually transmitted infections, use of more sensitive diagnostic methods, improved reporting and avoidance of unsafe sexual behaviour among certain subpopulations as well as education are essential in the prevention of sexually transmitted coinfections.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Bőr-, Nemikórtani és Bőronkológiai Klinika Budapest Mária u. 41. 1085.
authors.forename: Márta
authors.initials: M
authors.lastname: Marschalkó
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Bőr-, Nemikórtani és Bőronkológiai Klinika Budapest Mária u. 41. 1085.
authors.forename: Katinka
authors.initials: K
authors.lastname: Pónyai
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Bőr-, Nemikórtani és Bőronkológiai Klinika Budapest Mária u. 41. 1085.
authors.forename: Sarolta
authors.initials: S
authors.lastname: Kárpáti
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology; D060085:Coinfection; D014943:Global Health; D006069:Gonorrhea / Q000150:complications* / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D006801:Humans; D012307:Risk Factors; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000150:complications; D013587:Syphilis / Q000150:complications* / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; MSM; STD; STI; chlamydia; coinfections; gonorrhoea; hepatitis B; hepatitis C; koinfekció; syphilis