title: [Arterial remodeling in middle cerebral artery atherosclerotic stenosis:a high-resolution MRI study].
abstract: OBJECTIVE
  To investigate remodeling mode of moderate or severe atherosclerotic stenosis of the middle cerebral artery (MCA) using high resolution MRI.
  
  
  METHODS
  Thirty-seven consecutive symptomatic patients with atherosclerotic MCA stenosis were imaged with a 3.0-T magnetic resonance scanner. The HR-MRI protocol included four different scans: T1-weighted black blood imaging, T2-weighted MR, proton density (PD)-weighted MR, and 3D-SPACE. The wall area (VA), lumen area (LA) and plaque area (PA) were calculated. The characterization of the plaque on HR-MRI was analysed. And the difference between positive remodeling (PR) and non-postive remodeling (non-PR) was explored.
  
  
  RESULTS
  Thirty-four patients imaging was appropriate for analyse. Positive remodeling was found in 19 lesions. Compared with the non-PR group, the PR group had greater WA [(10.9 ± 2.5) mm² and (9.2 ± 1.9) mm², P = 0.039)] and greater PA [(6.4 ± 1.9) mm² and (3.9 ± 1.1) mm², P = 0]. High intensity on DWI and irregularity of plaque surface were more frequently observed in PR than non-PR.
  
  
  CONCLUSIONS
  In patients with MCA atherosclerosis, PR lesions contain larger plaques than non-PR lesions and are probably with high risk for plaque rupture and subsequent stroke.
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Dengling
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China. Email: gjteng@vip.sina.com.
authors.forename: Gaojun
authors.initials: G
authors.lastname: Teng
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Shenghong
authors.initials: S
authors.lastname: Ju
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Haimei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
authors.forename: Zhaorui
authors.initials: Z
authors.lastname: Hou
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D003251:Constriction, Pathologic; D006801:Humans; D008279:Magnetic Resonance Imaging; D020768:Middle Cerebral Artery; D058226:Plaque, Atherosclerotic; D020521:Stroke