title: Spatial aspects of blood coagulation: two decades of research on the self-sustained traveling wave of thrombin.
abstract: In a number of experimental studies, it has been demonstrated that the forefront of blood coagulation can propagate in the manner of a signal relay. These data strongly support the concept that the formation of a blood clot is governed by a self-sustained traveling wave of thrombin. The present review critically appraises the experimental data obtained in recent decades concerning the self-sustained spatial propagation of thrombin. Open questions regarding the experimental detection of the self-sustained propagation of thrombin are discussed.
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Guria
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia; National Research Center for Hematology, Moscow, 125167, Russia. Electronic address: guria@blood.ru.
authors.forename: Georgy Th
authors.initials: GT
authors.lastname: Guria
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D006467:Hemophilia A / Q000378:metabolism; D002836:Hemophilia B / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D013917:Thrombin / Q000032:analysis / Q000378:metabolism*
chemical_list: D001779:Blood Coagulation Factors; D013917:Thrombin
keywords: Blood coagulation; Spatial thrombus formation; Thrombin travelling waves