title: Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations.
abstract: Breast cancer incidence continues to increase in the US and Europe, a reflection of the growing influence of environment factors that interact with personal genetics. The US Environmental Protection Agency estimates that there are approximately 10,000 endocrine disrupting chemicals among the common daily exposures that could affect the risk of disease. The daunting tasks of identifying, characterizing, and elucidating the mechanisms of endocrine disrupting chemicals in breast cancer need to be addressed to produce a comprehensive model that will facilitate preventive strategies and public policy. An expert panel met to describe and bring attention to needs linking common environmental exposures, critical windows of exposure, and optimal times of assessment in investigating breast cancer risk. The group included investigators with extensive experience in the use of rodent models and in leading population studies and produced a set of recommendations for effective approaches to gaining insights into the environmental origins of breast cancer across the lifespan.
authors.affiliation: Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Teitelbaum
authors.affiliation: Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Belpoggi
authors.affiliation: National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address: reinlib@niehs.nih.gov.
authors.forename: Les
authors.initials: L
authors.lastname: Reinlib
mesh_terms: D000367:Age Factors; D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D004198:Disease Susceptibility; D052244:Endocrine Disruptors / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D042361:Mammary Glands, Human / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D046468:Sexual Development; D013997:Time Factors
chemical_list: D002274:Carcinogens, Environmental; D052244:Endocrine Disruptors
keywords: Breast cancer; Endocrine disrupting chemicals; Mammary gland biology; Windows of susceptibility