title: An exclusively based parenteral fish-oil emulsion reverses cholestasis.
abstract: Prolonged parenteral nutrition (PN) leads to liver damage. Recent interest has focused on the lipid component of PN. A lipid emulsion based on w-3 fatty acids decrease conjugated bilirubin. A mixed lipid emulsion derived from soybean, coconut, olive, and fish oils reverses jaundice. Here we report the reversal of cholestasis and the improvement of enteral feeding tolerance in 1 infant with intestinal failure-associated liver disease. Treatment involved the substitution of a mixed lipid emulsion with one containing primarily omega-3 fatty acids during 37 days. Growth and biochemical tests of liver function improved significantly. This suggests that fat emulsions made from fish oils may be more effective means of treating this condition compared with an intravenous lipid emulsion containing soybean oil, medium -chain triglycerides, olive oil, and fish oil.
authors.affiliation: Neonatology Department, La Paz University Hospital, Madrid, España.. mtrianaj@hotmail.com.
authors.forename: Miryam
authors.initials: M
authors.lastname: Triana Junco
authors.affiliation: Pharmacy Department, La Paz University Hospital, Madrid, España.. mnatalia.garcia@salud.madrid.org.
authors.forename: Natalia
authors.initials: N
authors.lastname: García Vázquez
authors.affiliation: Neonatology Department, La Paz University Hospital, Madrid, España.. zozaia6@hotmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Zozaya
authors.affiliation: Neonatology Department, La Paz University Hospital, Madrid, España.. martamenciaybarra@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Ybarra Zabala
authors.affiliation: Baylor College of Medicine, Houston, Texas.. sabrams@bcm.edu.
authors.forename: Steven
authors.initials: S
authors.lastname: Abrams
authors.affiliation: Intensive Care Unit, La Paz University Hospital, Madrid, España.. agdl@telefonica.net.
authors.forename: Abelardo
authors.initials: A
authors.lastname: García de Lorenzo
authors.affiliation: Neonatology Department, La Paz University Hospital, Madrid, España.. miguel.saenz@salud.madrid.org.
authors.forename: Miguel
authors.initials: M
authors.lastname: Sáenz de Pipaón Marcos
mesh_terms: D002779:Cholestasis / Q000188:drug therapy*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D020139:Gastroschisis / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010288:Parenteral Nutrition; D013024:Soybean Oil / Q000008:administration & dosage / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides; D013024:Soybean Oil