title: Effect of combination of ketanserin and escitalopram on behavioral anomalies after olfactory bulbectomy: prediction of quick onset of antidepressant action.
abstract: OBJECTIVE
  Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant drugs. The addition of low dose of 5-hydroxytryptamine type 2A enhances the therapeutic effect of SSRIs. The purpose of the present studies was to test the effects of combined treatment of a low dose of ketanserin (KET) and escitalopram (ESC) on behavioral anomalies occurring after olfactory bulbectomy (OBX).
  
  
  METHODS
  Chronic Depression was induced by OBX as shown in behavioral tests such as Open field, social interaction, and hyperemotionality tests. Acute and chronic treatment effect of KET, ESC, and combination was administered to the OBX rats.
  
  
  RESULTS
  Chronic (14 days) treatment with KET (1 mg/kg) or ESC (10 mg/kg) alleviated the behavioral anomalies of olfactory bulbectomized rats in modified open field exploration, social interaction, hyperemotionality. When KET treatment was combined with ESC, a short duration regimen (7 days) was sufficient to reverse the bulbectomy-induced anomalies.
  
  
  CONCLUSIONS
  The combination therapy as a likely strategy to achieve an early-onset of antidepressant action.
authors.affiliation: Department of Pharmacology, Novel Drug Discovery and Development, Lupin Ltd, Research Park, Nanded Village, Pune, Maharashtra, India.
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Pandey
authors.affiliation: Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
authors.forename: Shvetank
authors.initials: S
authors.lastname: Bhatt
authors.affiliation: Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Jindal
authors.affiliation: Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
authors.forename: Baldev
authors.initials: B
authors.lastname: Gautam
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D015283:Citalopram / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D007398:Interpersonal Relations; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D009830:Olfactory Bulb / Q000601:surgery; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents; D015283:Citalopram; D007650:Ketanserin
keywords: Antidepressant action; escitalopram; ketanserin; olfactory bulbectomy