title: Modelling bladder cancer in mice: opportunities and challenges.
abstract: The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: 1] Department of Urology, Columbia University Medical Center. [2] Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.
authors.forename: Tomasz B
authors.initials: TB
authors.lastname: Owczarek
authors.affiliation: Department of Urology, Columbia University Medical Center.
authors.forename: James M
authors.initials: JM
authors.lastname: McKiernan
authors.affiliation: 1] Department of Urology, Columbia University Medical Center. [2] Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA. [3] Department of Systems Biology, Columbia University Medical Center, New York, New York 10032, USA. [4] Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Abate-Shen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D052138:Genes, Neoplasm; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology* / Q000628:therapy