title: Host-pathogen interactions during porcine reproductive and respiratory syndrome virus 1 infection of piglets.
abstract: Porcine reproductive and respiratory syndrome (PRRS) is a major disease affecting pigs worldwide and resulting in considerable economic losses. While PRRS is a global phenomenon, the causative viruses PRRSV-1 (first detected in Europe) and PRRSV-2 (isolated in North America) are genetically and biologically distinct. In addition, the disease outcome is directly linked to co-infections associated with the porcine respiratory disease complex and the host response is variable between different breeds of pigs. It is therefore warranted when studying the pathogenesis of PRRS to consider each viral genotype separately and apply careful consideration to the disease model studied. We here review the respiratory pig model for PRRSV-1, with a focus on a recent set of studies conducted with carefully selected virus strains and pigs, which may serve as both a baseline and benchmark for future investigation.
authors.affiliation: Virology Department, Animal and Plant Health Agency, Weybridge, Addlestone, United Kingdom; Department of Pathology and Infectious Diseases, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Salguero
authors.affiliation: Virology Department, Animal and Plant Health Agency, Weybridge, Addlestone, United Kingdom. Electronic address: Jean-Pierre.Frossard@apha.gsi.gov.uk.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Frossard
authors.affiliation: Department of Infection Biology, Central Veterinary Institute, Lelystad, The Netherlands.
authors.forename: Johanna M J
authors.initials: JM
authors.lastname: Rebel
authors.affiliation: Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stadejek
authors.affiliation: Virology Department, Animal and Plant Health Agency, Weybridge, Addlestone, United Kingdom.
authors.forename: Sophie B
authors.initials: SB
authors.lastname: Morgan
authors.affiliation: Virology Department, Animal and Plant Health Agency, Weybridge, Addlestone, United Kingdom; Department of Pathology and Infectious Diseases, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom.
authors.forename: Simon P
authors.initials: SP
authors.lastname: Graham
authors.affiliation: Virology Department, Animal and Plant Health Agency, Weybridge, Addlestone, United Kingdom; Department of Pathology and Infectious Diseases, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom.
authors.forename: Falko
authors.initials: F
authors.lastname: Steinbach
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005060:Europe; D054884:Host-Pathogen Interactions; D009656:North America; D019318:Porcine Reproductive and Respiratory Syndrome / Q000473:pathology* / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000821:virology
keywords: Disease model; Immune response; PRRSV