title: Tumour-to-tumour metastasis from papillary thyroid carcinoma with BRAF mutation to lung adenocarcinoma with EGFR mutation: the utility of mutation-specific antibodies.
abstract: OBJECTIVE
  Tumour-to-tumour metastasis is a rare event. The aim of this study is to demonstrate the utility of mutation-specific antibodies to prove the occurrence of metastatic papillary thyroid cancer donor into lung adenocarcinoma recipient.
  
  
  RESULTS
  We report the case of an 80-year-old woman who had a papillary thyroid carcinoma with a v-raf murine sarcoma viral oncogene homologue B1 mutation that metastasized into a lung adenocarcinoma with an epidermal growth factor receptor mutation. Immunohistochemical analysis with mutation-specific antibodies not only clearly revealed two components, but also revealed their gene mutation statuses.
  
  
  CONCLUSIONS
  As a component of multimodal diagnostic tools, immunohistochemistry can avoid some pitfalls involved in the molecular diagnosis of complicated cases (such as our own) and can help to ensure that patients receive optimal treatments.
authors.affiliation: Division of Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan.|Department of Thoracic Oncology, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katsuya
authors.affiliation: Division of Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Division of Thoracic Surgery, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Division of Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000235:genetics; D002291:Carcinoma, Papillary; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics; D016609:Neoplasms, Second Primary; D027384:Oncogene Proteins v-raf / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors; C482119:BRAF protein, human; D027384:Oncogene Proteins v-raf; D048493:Proto-Oncogene Proteins B-raf
keywords: gene mutation; immunohistochemistry; lung adenocarcinoma; papillary thyroid tumour; tumour-to-tumour metastasis