title: An unusual cause of jaundice in a patient with breast cancer.
abstract: A 48-year old woman with metastatic breast cancer and extensive bone marrow infiltration was admitted with extreme lethargy, jaundice and deranged liver function tests. She had been started on anastrozole in May 2013 for bony metastases, detected on a bone scan. A CT scan performed at that time had shown no evidence of metastatic or nodal disease elsewhere. Over the subsequent 2 months, the patient had become progressively jaundiced. Outpatient abdominal ultrasound and CT liver had shown a fatty liver with no focal lesions. She was admitted in August 2013 with bilirubin 567, alkaline phosphatase 385, alanine aminotransferase 98, albumin 25 and international normalised ratio 1.9. The patient ultimately had a liver biopsy, which demonstrated features of drug-induced steatohepatitis, and anastrozole was found to have been the probable cause. This case explores the differentials of jaundice in a patient with cancer and describes a rare cause of drug-induced liver injury.
authors.affiliation: Department of Gastroenterology, Royal Berkshire NHS Trust, Reading, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Lacey
authors.affiliation: Department of Gastroenterology, Royal Berkshire NHS Trust, Reading, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Evans
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008111:Liver Function Tests; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects* / Q000627:therapeutic use; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole