title: Ceftriaxone-induced acute encephalopathy in a peritoneal dialysis patient.
abstract: Encephalopathy is a rare side effect of third and fourth generation cephalosporins. Renal failure and preexisting neurological disease are notable risk factors. Recognition is important as discontinuing the offending agent usually resolves symptoms. We present a case of acute encephalopathy in a patient with end stage renal disease (ESRD) treated with peritoneal dialysis (PD) who received intravenous ceftriaxone for peritonitis. This case illustrates the potential severe neurologic effects of cephalosporins, which are recommended by international guidelines as first-line antimicrobial therapy for spontaneous bacterial peritonitis.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Sami
authors.initials: S
authors.lastname: Safadi
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Mao
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Dillon