title: The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease.
abstract: Coronary artery disease (CAD), being a multifactorial disease process, has been suggested to be associated by the interaction of both environmental and genetic risk factors. Toll-like receptors (TLRs) are related to the receptors of the innate immune system which serves as the recognition of the conserved pathogen motifs and the activation of the signals that stimulate inflammatory genes. In this study, we investigated the relationship between the polymorphisms in the TLR2-Arg753Gly, TLR4-Asp299Gly and Thr399Ile gene and CAD. The study population consisted of 300 patients (149 men, 151 women) with angiographically documented CAD. The polymorphisms were genotyped by real time PCR. No association between TLR2-Arg677Trp or TLR4-Asp299Gly and -Thr399Ile gene polymorphisms and the presence or the severity of CAD was observed. On the other hand, the TLR2-Arg753Arg genotype seemed to have a protective effect against development of CAD (OR=0.17; 95% CI=0.04-0.83). Our findings suggest that TLR2-Arg753Gly polymorphism is associated with CAD susceptibility in Turkish patients.
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey. Electronic address: mgguven@istanbul.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Guven
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey.
authors.forename: Ziya
authors.initials: Z
authors.lastname: Ismailoglu
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Batar
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
authors.forename: Selin
authors.initials: S
authors.lastname: Unal
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Onaran
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey.
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Karadag
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Ongen
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014421:Turkey
chemical_list: C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
keywords: Atherosclerosis; Coronary artery disease; Polymorphism; TLR2; TLR4; Toll-like receptors