title: Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis.
abstract: BACKGROUND
  The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis.
  
  
  METHODS
  The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups.
  
  
  RESULTS
  No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups.
  
  
  CONCLUSIONS
  According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Mardanian
authors.affiliation: Department of Anatomical Sciences, Head of Infertility Laboratory, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Roshanak
authors.initials: R
authors.lastname: Aboutorabi
authors.affiliation: Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Jefride
authors.affiliation: Department of Genetics, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Guilda
authors.initials: G
authors.lastname: Amini
keywords: Endometriosis; polymorphism; tumor necrosis factor