title: Magnolol reduces UVB-induced photodamage by regulating matrix metalloproteinase activity.
abstract: In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically examining the epidermal thickness, and identifying damage to the collagen fibers. The protective effects of magnolol on UVB-induced skin photoaging were examined by determining the level of MMPs and mitogen-activated protein kinases (MAPKs). Exposure to UVB radiation significantly increased skin thickness and wrinkle grade, but magnolol treatment significantly reduced the average length and depth of wrinkles, and this was correlated with the inhibition of collagen fiber loss. The magnolol-treated group had remarkably decreased activity levels of MMP-1, -9, and -13 compared to the corresponding levels in the vehicle-treated UVB-irradiated group. These results indicate that magnolol prevents skin photoaging in UVB-irradiated hairless mice.
authors.affiliation: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Daejeon, 305-811, Yuseong-gu, Korea.
authors.forename: A-Rang
authors.initials: AR
authors.lastname: Im
authors.affiliation: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Daejeon, 305-811, Yuseong-gu, Korea.
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Song
authors.affiliation: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Daejeon, 305-811, Yuseong-gu, Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.affiliation: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Daejeon, 305-811, Yuseong-gu, Korea; Korean Medicine Life Science, University of Science and Technology, Daejeon, 305-333, Korea. Electronic address: kendall@kiom.re.kr.
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chae
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008812:Mice, Hairless; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; D003094:Collagen; D020928:Mitogen-Activated Protein Kinases; D020782:Matrix Metalloproteinases
keywords: Antiwrinkle; MAPKs; MMP; Magnolol; UVB irradiation