title: Advantame sweetener preference in C57BL/6J mice and Sprague-Dawley rats.
abstract: Advantame is a new ultrahigh-intensity noncaloric sweetener derived from aspartame and approved for human use. Rats and mice are not attracted to the taste of aspartame and this study determined their preference for advantame. In 24-h choice tests with water, C57BL/6J mice and Sprague-Dawley rats were indifferent to advantame at concentrations of 0.01, 0.03, and 0.1mM but significantly preferred 0.3 and 1mM advantame to water. Both species also preferred 1mM advantame to 1mM saccharin in direct choice tests, but preferred 10mM saccharin to 1mM advantame, which is near the solubility limit for this sweetener. Mice also preferred 1mM advantame to 1mM sucralose or acesulfame K, but preferred both sweeteners at 10mM to 1mM advantame. In addition, mice preferred 1mM advantame to 1 and 10mM aspartame. Thus, advantame is a potent sweetener for rodents but, because of limited solubility, is not an effective alternative to saccharin, sucralose, or acesulfame K at higher concentrations.
authors.affiliation: Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA asclafani@gc.cuny.edu.
authors.forename: Anthony
authors.initials: A
authors.lastname: Sclafani
authors.affiliation: Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Ackroff
mesh_terms: D000818:Animals; D002755:Choice Behavior; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D005247:Feeding Behavior; D005260:Female; D005518:Food Preferences; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin / Q000737:chemistry*; D012995:Solubility; D013045:Species Specificity; D013395:Sucrose / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013549:Sweetening Agents / Q000737:chemistry / Q000494:pharmacology*; D013843:Thiazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004151:Dipeptides; D013549:Sweetening Agents; D013843:Thiazines; C570172:N-(N-(3-(3-hydroxy-4-methoxyphenyl) propyl)-alpha-aspartyl)-L-phenylalanine 1-methyl ester; D013395:Sucrose; C026285:trichlorosucrose; D012439:Saccharin; C006362:acetosulfame
keywords: acesulfame K; aspartame; saccharin; sucralose