title: Two new coumarin glycosides from Herpetospermum caudigerum.
abstract: Phytochemical investigation on the seeds of Herpetospermum caudigerum afforded two new coumarin glycosides A and B (1 and 2), together with a known compound herpetolide A (3). Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compound 3 exhibited cytotoxicity against HepG2 cells with IC50 value of 6.47 μg/ml. Compound 2 showed anti-hepatitis B virus activity with HBsAg secretion by 33.1% at 200 μg/ml.
authors.affiliation: a Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University , Chongqing 400715 , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Fan
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Deng
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Chen
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019662:Cucurbitaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D003374:Coumarins; D006027:Glycosides; C000602166:herpetosperin A; C000602167:herpetosperin B
keywords: Herpetospermum caudigerum; coumarin glycoside; herpetosperin A; herpetosperin B