title: [An expert system for differential diagnosis of medullary and oxyphilic cell thyroid carcinoma].
abstract: OBJECTIVE
  To reveal the quantitative regularities of pathological changes in the nuclei and aggregates of C and B cells and to build an expert system on their basis for the differential diagnosis of medullary and oxyphilic cell thyroid carcinoma.
  
  
  METHODS
  Puncture smears with histologically verified medullary (C cell) carcinoma and oxyphilic cell (B cell) carcinoma were investigated. The nuclei and aggregates of C cells and B cells (Hürthle cells, oncocytes) were morphometrically examined with a computer color image analyzer on the basis of a light microscope and a digital photo camera.
  
  
  RESULTS
  The quantitative regularities of the degree of C and B cell aggregation in medullary and oxyphilic cell thyroid carcinoma were found by morphometry. The threshold values for the aggregates in the comparison groups and their weight coefficients formed the basis for the expert system to differentially diagnose medullary and oxyphilic cell carcinoma at the initial stages of patient examination. The clinical trials showed the high efficiency of the developed expert system.
authors.forename: V A
authors.initials: VA
authors.lastname: Kirillov
authors.forename: O A
authors.initials: OA
authors.lastname: Emel'ianova
authors.forename: A O
authors.initials: AO
authors.lastname: Gladyshev
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000473:pathology; D002449:Cell Aggregation; D003937:Diagnosis, Differential; D005103:Expert Systems; D006801:Humans; D024862:Oxyphil Cells / Q000473:pathology; D057089:Pathology, Molecular; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology