title: 5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro.
abstract: BACKGROUND
  5-HT3 receptor antagonists are effective antiemetics for perioperative use. However, their effects on myometrial contractility remain unknown. We examined whether three different 5-HT3 receptor antagonists could affect the contraction of human myometrium.
  
  
  METHODS
  Samples of human myometrium were taken from parturients undergoing elective cesarean delivery. Effects of ondansetron, granisetron and tropisetron (over a range of 1-10(4)ng/mL) on spontaneous contraction (ratios of amplitude, interval, and duration of the contraction) were examined and compared to saline controls (n=6 for each agent).
  
  
  RESULTS
  None of the three 5-HT3 receptor antagonists significantly affected myometrial contraction.
  
  
  CONCLUSIONS
  5-HT3 receptor antagonists do not affect the contraction of myometrial strips isolated from term pregnant women.
authors.affiliation: Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology, Nanchong Central Hospital, Second Clinical Medical Institution of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zeng
authors.affiliation: Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: liujin_hx@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
mesh_terms: D005260:Female; D017829:Granisetron / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D017294:Ondansetron / Q000494:pharmacology; D011247:Pregnancy; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D017829:Granisetron; D007211:Indoles; D017294:Ondansetron; D012702:Serotonin Antagonists; D000077526:Tropisetron
keywords: 5-HT3 receptor antagonists; Myometrium; Term pregnancy