title: The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors.
abstract: OBJECTIVE
  The hypolipidemic and antiobesogenic effects of tea intake have been associated with bioactive compounds that regulate peroxisome proliferator-activated receptors (PPARs). This review describes the recent research on two of these compounds, (-)-epigallocatechin gallate (EGCG) and linalool.
  
  
  RESULTS
  Catechins (specifically EGCG) are key bioactive compounds found in tea, and a recent study has shown that linalool may also be an active tea compound. These compounds act on lipid metabolism by regulating PPAR subtypes. EGCG inhibits the key adipogenic transcription factor PPARγ while activating PPARα, whereas linalool is a PPARα agonist activating hepatic fatty acid uptake and subsequent oxidation to reduce plasma triglyceride levels.
  
  
  CONCLUSIONS
  The collective activities of EGCG and linalool in tea may exert hypolipidemic and antiobesogenic effects by regulating PPARs. The research summarized in this review expands our understanding of the biological and physiological mechanisms of the bioactive compounds found in tea.
authors.affiliation: aDepartment of Biotechnology, Graduate School of Life Sciences & Biotechnology and Brain Korea 21-PLUS Program bDepartment of Food Biosciences and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
authors.forename: Sung-Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D039821:Monoterpenes / Q000494:pharmacology / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*; D013662:Tea / Q000737:chemistry*
chemical_list: D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D047492:Peroxisome Proliferator-Activated Receptors; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; C018584:linalool