title: Diagnostic value of the REM sleep behavior disorder screening questionnaire in Parkinson's disease.
abstract: OBJECTIVE
  We aimed to validate the rapid eye movement (REM) sleep behavior disorder (RBD) screening questionnaire (RBDSQ) in 2 independent samples of patients with Parkinson's disease (PD) using different settings when performing the investigations.
  
  
  METHODS
  The RBDSQ was administered to two independent samples of 52 and 75 consecutive PD patients investigated with video-polysomnography (vPSG).
  
  
  RESULTS
  In sample A, the RBDSQ identified 46/52 (88.5%) patients correctly. In sample B, 50/75 (66.7%) patients were identified correctly. Considering a cut-off score of ≥ 5 as a positive test result, sample A showed a sensitivity of 0.90 and a specificity of 0.87, sample B showed a sensitivity of 0.68 and a specificity of 0.63. Main differences between both groups were that patients of sample A underwent a sleep history including RBD assessment prior to administration of the RBDSQ, whereas in sample B the RBDSQ was administered during routine work-up.
  
  
  CONCLUSIONS
  The diagnostic value of the RBDSQ strongly depends on the clinical setting and may be influenced by the individual's awareness on RBD. This finding is a critical issue which deserves clarification before use of this and other questionnaires can be recommended in epidemiological studies.
authors.affiliation: Somnomar, Institute for Medical Research and Sleep Medicine, Marburg, Germany; Philipps-University, Marburg, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Stiasny-Kolster
authors.affiliation: Paracelsus-Elena Klinik, Kassel, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Sixel-Döring
authors.affiliation: Paracelsus-Elena Klinik, Kassel, Germany; University of Goettingen, Goettingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Trenkwalder
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Heinzel-Gutenbrunner
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Klaus
authors.initials: K
authors.lastname: Seppi
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Birgit
authors.initials: B
authors.lastname: Högl
authors.affiliation: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: birgit.frauscher@i-med.ac.at.
authors.forename: Birgit
authors.initials: B
authors.lastname: Frauscher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D017286:Polysomnography; D011237:Predictive Value of Tests; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000209:etiology; D012372:ROC Curve; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D000978:Antiparkinson Agents
keywords: Disease awareness; Parkinson's disease; REM sleep behavior disorder; Screening questionnaire; Sensitivity; Specificity