title: Metastatic Melanoma in the Femur - Case Report with Review of Literature: a Pathologist's Point of View.
abstract: The aim of this case report was to evaluate the histopathological characteristics on a patient with metastases in the femur from malignant melanoma. A review from the literature is also mentioned.We present a case of metastatic malignant melanoma in the femur with known primary site in a 44-year-old-female. Diagnosis was confirmed by histopathology.Malignant melanoma is a cancer that may metastasise in the skeleton. However most of bone metastases are found in the axial skeleton and they rarely involve the femur, as in our case. Only a few case reports are published in the literature. Clinicians must be aware of the varied clinical manifestations of disseminated malignant melanoma.The diagnosis for metastatic malignant melanoma is confirmed due to pathological examination. Immunohistochemical study is useful in diagnosis, mainly when malignant melanoma is poorly differen-tiated.
authors.affiliation: Department of Pathology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Costache
authors.affiliation: Department of Pathology, Emergency University Hospital Bucharest, Romania.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Stoica
authors.affiliation: Department of Pathology, Emergency University Hospital Bucharest, Romania.
authors.forename: Andreea
authors.initials: A
authors.lastname: Contolenco
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Diana
authors.initials: D
authors.lastname: Costache
authors.affiliation: Department of Orthopaedics and Traumatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Cirstoiu
authors.affiliation: Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Olga
authors.initials: O
authors.lastname: Simionescu
authors.affiliation: Department of Pathology, Emergency University Hospital Bucharest, Romania.
authors.forename: Simion
authors.initials: S
authors.lastname: George
keywords: femur; malignant melanoma; metastases