title: Seminal megavesicle in autosomal dominant polycystic kidney disease.
abstract: Retrospective analysis of 99 male autosomal dominant polycystic kidney disease (ADPKD) patients compared to an age-matched control population showed seminal vesicle ectasia >10 mm (megavesicle) in 23% (23/99) of ADPKD patients that was not present in any controls (P<.0001). Median (range) seminal vesicle convoluted tubule diameter in ADPKD patients was 4.2 (1.7-30) mm compared to 3.1 (1.7-6.8) mm in controls (P<.0001). Discrete cysts were identified in four ADPKD patients but in none of the control population (P=.12). Seminal megavesicles may explain the infertility sometimes observed in male ADPKD patients.
authors.affiliation: Department of Radiology, Weill Cornell Medical Center, 416 East 55th Street, New York, NY.
authors.forename: Beatriu
authors.initials: B
authors.lastname: Reig
authors.affiliation: Department of Medicine, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021; The Rogosin Institute 505 East 70th Street, New York, NY 10021.
authors.forename: Jon
authors.initials: J
authors.lastname: Blumenfeld
authors.affiliation: The Rogosin Institute 505 East 70th Street, New York, NY 10021.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Donahue
authors.affiliation: Department of Radiology, Weill Cornell Medical Center, 416 East 55th Street, New York, NY. Electronic address: map2008@med.cornell.edu.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Prince
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies; D012669:Seminal Vesicles / Q000473:pathology*
keywords: Autosomal dominant poylcystic kidney disease; Cyst; Infertility; Magnetic resonance imaging; Seminal vesicle ectasia