title: Carriebowlinol, an antimicrobial tetrahydroquinolinol from an assemblage of marine cyanobacteria containing a novel taxon.
abstract: A combined biodiversity- and bioassay-guided natural products discovery approach was used to explore new groups of marine cyanobacteria for novel secondary metabolites with ecologically relevant bioactivities. Phylogenetic analysis of cyanobacterial collections from Belize revealed a new taxon not previously well explored for natural products. The new alkaloid 5-hydroxy-4-(chloromethyl)-5,6,7,8-tetrahydroquinoline (1), named carriebowlinol, and the known compound lyngbic acid (2) were isolated from a nonpolar extract and identified by NMR and MS techniques. Compounds 1 and 2 inhibited the growth of pathogenic and saprophytic marine fungi, and 1 inhibited the growth of marine bacteria, suggesting an antimicrobial ecological function.
authors.affiliation: †Smithsonian Marine Station at Fort Pierce, Fort Pierce, Florida 34949, United States.|‡Núcleo em Ecologia e Desenvolvimento Socioambiental de Macaé, Grupo de Produtos Naturais de Organismos Aquáticos (GPNOA), Universidade Federal do Rio de Janeiro, Caixa Postal 119331, Macaé, RJ CEP 27910-970, Brazil.
authors.forename: Angélica R
authors.initials: AR
authors.lastname: Soares
authors.affiliation: †Smithsonian Marine Station at Fort Pierce, Fort Pierce, Florida 34949, United States.|§Department of Biological Sciences, Florida International University, Miami, Florida 33199, United States.
authors.forename: Niclas
authors.initials: N
authors.lastname: Engene
authors.affiliation: †Smithsonian Marine Station at Fort Pierce, Fort Pierce, Florida 34949, United States.
authors.forename: Sarath P
authors.initials: SP
authors.lastname: Gunasekera
authors.affiliation: †Smithsonian Marine Station at Fort Pierce, Fort Pierce, Florida 34949, United States.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Sneed
authors.affiliation: †Smithsonian Marine Station at Fort Pierce, Fort Pierce, Florida 34949, United States.
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Paul
mesh_terms: D000470:Alkaloids / Q000378:metabolism; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001531:Belize; D044822:Biodiversity; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010802:Phylogeny; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011809:Quinones
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D001688:Biological Products; D011804:Quinolines; D011809:Quinones; C000598676:carriebowlinol; C528846:5,6,7,8-tetrahydroquinoline