title: Reversible splenial lesion on the corpus callosum in nonfulminant hepatitis A presenting as encephalopathy.
abstract: Reversible focal lesions on the splenium of the corpus callosum (SCC) have been reported in patients with mild encephalitis/encephalopathy caused by various infectious agents, such as influenza, mumps, adenovirus, Varicella zoster, Escherichia coli, Legionella pneumophila, and Staphylococcus aureus. We report a case of a reversible SCC lesion causing reversible encephalopathy in nonfulminant hepatitis A. A 30-year-old healthy male with dysarthria and fever was admitted to our hospital. After admission his mental status became confused, and so we performed electroencephalography (EEG) and magnetic resonance imaging (MRI) of the brain, which revealed an intensified signal on diffusion-weighted imaging (DWI) at the SCC. His mental status improved 5 days after admission, and the SCC lesion had completely disappeared 15 days after admission.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Ko
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Jeong Han
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Won Hyeok
authors.initials: WH
authors.lastname: Choe
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Seo
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D003404:Creatinine / Q000097:blood; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications / Q000175:diagnosis*; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D006435:Renal Dialysis
chemical_list: D003404:Creatinine; D000410:Alanine Transaminase
keywords: Acute hepatitis A; Corpus callosum; Encephalopathy; Magnetic resonance imaging