title: Phytochemical Investigation on Euphorbia macrostegia (Persian wood spurge).
abstract: Euphorbia macrostegia or Persian wood spurge is one of the seventeen endemic plants of this genus in Iran. Three triterpenoids, 24-methylenecycloartan-3β-ol (1), butyrospermol (2) and cycloartenol (3) and three diglycerides, 1,2-di-O-α-linolenoyl-sn-glycerol (4), 1-O-linoleoyl-3-O-palmitoyl-sn-glycerol (5) and 1-O-α-linolenoyl-2-O-palmitoyl-sn-glycerol (6) were isolated from the hexane soluble part of methanol-dichloromethane extracts of the aerial parts of Euphorbia macrostegia Boiss. The structures of all compounds were elucidated using different spectroscopy methods including, (1)H NMR, (13)C NMR, HSQC, HMBC, EI-MS and IR. The triterpenes and the unsaturated fatty acids moieties of the diglycerides isolated from the plant were reported previously to have analgesic, anticancer, bactericidal and antifungal activity. Here, we show that E. macrostegia is a new source for the above mentioned biologically active compounds.
authors.affiliation: Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ; Department of Phytochemistry, Yasouj University, Yasouj 75914-353, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Zare
authors.affiliation: Department of Phytochemistry, Yasouj University, Yasouj 75914-353, Iran.
authors.forename: Mehrorang
authors.initials: M
authors.lastname: Ghaedi
authors.affiliation: Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Miri
authors.affiliation: Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans -Knöll -Strasse 8, D-07745 Jena, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Heiling
authors.affiliation: Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Asadollahi
authors.affiliation: Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans -Knöll -Strasse 8, D-07745 Jena, Germany.
authors.forename: Ian
authors.initials: I
authors.lastname: T Baldwin
authors.affiliation: Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jassbi
keywords: Cycloartane triterpenoids; Diglycerides of fatty acids; Euphorbia macrostegia; Euphorbiaceae