title: NLRP1 L155H Polymorphism is a Risk Factor for Preeclampsia Development.
abstract: OBJECTIVE
  Augmented levels of IL-1ß have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1ß cleavage and IL-1ß secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia.
  
  
  METHODS
  Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia.
  The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.
authors.affiliation: Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo/USP, Sao Paulo, SP, Brazil.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pontillo
authors.affiliation: Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo/USP, Sao Paulo, SP, Brazil.
authors.forename: Edione C
authors.initials: EC
authors.lastname: Reis
authors.affiliation: Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo/USP, Sao Paulo, SP, Brazil.
authors.forename: Pamela N
authors.initials: PN
authors.lastname: Bricher
authors.affiliation: Laboratory of Immunogenetics, Department of Genetics, Federal University of Rio Grande do Sul/UFRS, Porto Alegre, RS, Brazil.
authors.forename: Priscila
authors.initials: P
authors.lastname: Vianna
authors.affiliation: Nucleo de Pos-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
authors.forename: Solange
authors.initials: S
authors.lastname: Diniz
authors.affiliation: Nucleo de Pos-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
authors.forename: Karla S
authors.initials: KS
authors.lastname: Fernandes
authors.affiliation: Laboratory of Immunogenetics, Department of Genetics, Federal University of Rio Grande do Sul/UFRS, Porto Alegre, RS, Brazil.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Chies
authors.affiliation: Department of Pharmacology, Institute of Biosciences, University 'Estadual Paulista'/UNESP, Botucatu, SP, Brazil.
authors.forename: Valeria
authors.initials: V
authors.lastname: Sandrim
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000276:immunology; D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000276:immunology; D001938:Brazil; D005260:Female; D006801:Humans; D058847:Inflammasomes / Q000235:genetics / Q000276:immunology; D000070576:NLR Proteins; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D058847:Inflammasomes; D000070576:NLR Proteins; C427903:NLRP1 protein, human
keywords: IL-1ß; NLRP1; inflammasome; preeclampsia