title: Ethnic differences in the association of thrombophilic polymorphisms with obstetric complications in Slovak and Roma (Gypsy) populations.
abstract: OBJECTIVE
  Hereditary as well as acquired thrombophilia is associated with a higher incidence of severe obstetric complications such as preeclampsia, spontaneous pregnancy loss, placental abruption, and fetal growth retardation. The aim of our study was to examine the association of selected thrombophilic polymorphisms (factor V Leiden, MTHFR C677T, and MTHFR A1298C) with pregnancy complications in the Slovak majority population and the Roma (Gypsy) ethnic population. The study included 354 women; 120 patients and 105 controls from the Slovak majority population, 50 patients and 79 controls from the Slovak Roma population. Genotyping was performed by the real-time polymerase chain reaction method using TaqMan(®) MGB probes.
  
  
  RESULTS
  A statistically significant higher frequency of factor V Leiden (p=0.001, odds ratio [OR]=5.9) and MTHFR C677T polymorphism (p=0.011, OR=1.7) was observed in the Slovak majority patient group compared to the control group. The incidence of MTHFR A1298C polymorphism between patients and controls did not differ significantly. None of the three polymorphisms studied was in association with pregnancy complications in the group of Roma women.
  
  
  CONCLUSIONS
  Our study has confirmed the variable distribution of selected thrombophilic polymorphisms in different ethnic groups as well as their various effects on the clinical phenotype.
authors.affiliation: 1 Department of Biology, Faculty of Humanities and Natural Sciences, Presov University , Presov, Slovakia .
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bozikova
authors.forename: Dana
authors.initials: D
authors.lastname: Gabrikova
authors.forename: Jozef
authors.initials: J
authors.lastname: Pitonak
authors.forename: Jarmila
authors.initials: J
authors.lastname: Bernasovska
authors.forename: Sona
authors.initials: S
authors.lastname: Macekova
authors.forename: Regina
authors.initials: R
authors.lastname: Lohajova-Behulova
mesh_terms: D000026:Abortion, Habitual / Q000208:ethnology / Q000235:genetics; D020016:Activated Protein C Resistance / Q000208:ethnology / Q000235:genetics; D000293:Adolescent; D000328:Adult; D005006:Ethnicity / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D017354:Point Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011248:Pregnancy Complications / Q000208:ethnology* / Q000235:genetics; D011250:Pregnancy Complications, Hematologic / Q000208:ethnology / Q000235:genetics; D006178:Romani People / Q000235:genetics*; D018154:Slovakia / Q000453:epidemiology; D019851:Thrombophilia / Q000208:ethnology* / Q000235:genetics; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)