title: The use of botulinum neurotoxin type a in a patient with refractory urge incontinence to facilitate the intravesical treatment of bladder carcinoma.
abstract: Intravesical Bacillus Calmette-Guérin (BCG) has become the preferred initial treatment after resection of high-grade T1 urothelial carcinoma and carcinoma in situ (CIS). We report the case of a patient with high-grade T1 urothelial carcinoma and CIS who was treated with intravesical BCG. Due to the patient's severe urge incontinence, however, the BCG solution leaked from the bladder immediately upon instillation. We describe our experience of using botulinum neurotoxin A intradetrusor injections to facilitate successful intravesical therapy by increasing bladder capacity to enable the BCG to remain in the patient's bladder for the appropriate treatment duration.
authors.affiliation: Department of Surgery, Division of Urology, Rutgers New Jersey Medical School, Newark, NJ.
authors.forename: Mina
authors.initials: M
authors.lastname: Fam
authors.forename: Patricia
authors.initials: P
authors.lastname: Gilhooly
keywords: Bacillus Calmette-Guérin; Bladder carcinoma; Botulinum neurotoxin; Gemcitabine; Urge incontinence