title: Motor neuron disease in 2014. Biomarkers for ALS--in search of the Promised Land.
abstract: The past year has seen some extraordinary activity in clinical amyotrophic lateral sclerosis (ALS) research. Two trials were completed, with negative results, but the discovery of novel ALS-associated genes, and body fluid and imaging biomarkers warrants cautious optimism. Here, we provide a snapshot of some of the main findings in 2014.
authors.affiliation: Rita Levi Montalcini' Department of Neuroscience, University of Torino, via Cherasco 15, 10126 Torino, Italy.
authors.forename: Adriano
authors.initials: A
authors.lastname: Chiò
authors.affiliation: Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Traynor
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D012106:Research
chemical_list: D015415:Biomarkers