title: Atypical Parkinsonian syndromes with very poor striatal uptake on 123I-ioflupane SPECT imaging.
abstract: We report a case series of unusual I-ioflupane SPECT imaging findings. Three patients with atypical parkinsonian symptoms underwent I-ioflupane imaging to assist in diagnosis. The patients had complete or near-complete absence of striatal activity. The imaging deficit severity did not consistently correlate with the clinical deficit severity. These cases suggest that markedly abnormal uptake patterns may be seen with atypical parkinsonian syndromes. Further research is warranted to evaluate differences in I-ioflupane uptake patterns among the various parkinsonian syndromes.
authors.affiliation: From the *Department of Diagnostic Imaging, Alpert Medical School of Brown University and Rhode Island Hospital; and †Department of Neurology, Alpert Medical School of Brown University and Butler Hospital, Providence, RI.
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Dibble
authors.forename: Don C
authors.initials: DC
authors.lastname: Yoo
authors.forename: Richard B
authors.initials: RB
authors.lastname: Noto
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Friedman
mesh_terms: D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009662:Nortropanes; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009662:Nortropanes; D019275:Radiopharmaceuticals; C519528:ioflupane