title: Uterine endometrioid carcinoma with focal area of choriocarcinomatous differentiation: case report.
abstract: OBJECTIVE
  An endometrioid carcinoma coexisting with choriocarcinomatous differentiation is an uncommon event with an aggressive clinical course and a poor prognosis.
  
  
  METHODS
  The authors describe an endometrioid carcinoma of the endometrium provided with a focus of choriocarcinoma-like cells in a 50-year-old menstruated woman with a history of abnormal uterine bleeding. A total bilateral hystero-annessectomy was performed.
  
  
  RESULTS
  Histopathologic study showed endometrioid adenocarcinoma limited to the endometrium with a single microinvasive (< one mm) choriocarcinomatous focus. Immunohistochemistry established intense reactivity of tumor cells for CK 7 and AE1/AE3, for beta-human chorionic gonadotropin (beta-hCG), and for HER2 confirming the diagnosis. During the clinical course and follow-up, serum levels of beta-hCG were always negative. Up to date the patient is still alive with no evidence of disease.
  
  
  CONCLUSIONS
  Even if endometrioid carcinoma with choriocarcinomatous differentiation is considered highly malignant, occasionally it may have a good prognosis, especially when a non-invasive behaviour is detected together with negative serum beta-hCG levels.
authors.affiliation: Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy.  gasparecarta@libero.it
authors.forename: G
authors.initials: G
authors.lastname: Carta
authors.forename: V
authors.initials: V
authors.lastname: Accurti
authors.forename: M
authors.initials: M
authors.lastname: Di Nicola
authors.forename: G
authors.initials: G
authors.lastname: Crisman
authors.forename: L
authors.initials: L
authors.lastname: Sollima
authors.forename: A
authors.initials: A
authors.lastname: Carta
authors.forename: F
authors.initials: F
authors.lastname: Patacchiola
mesh_terms: D018269:Carcinoma, Endometrioid / Q000097:blood / Q000473:pathology*; D002454:Cell Differentiation; D002822:Choriocarcinoma / Q000473:pathology*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human