title: The translational revolution and use of biologics in patients with inflammatory skin diseases.
abstract: Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases characterized by immune-mediated inflammation and abnormal keratinocyte differentiation. Although T-cell infiltration characterizes both diseases, T-cell polarization differs. Psoriasis is currently the best model for translational medicine because many targeted therapeutics have been developed and testing of targeted therapeutics has cemented psoriasis as IL-23/TH17 polarized. In patients with AD, although therapeutic development is approximately a decade behind that in patients with psoriasis, there is now active development and testing of targeted therapeutics against various immune axes (TH2, TH22, and IL-23/TH17). These clinical trials and subsequent molecular analyses using human samples will be able to clarify the relative roles of polar cytokines in patients with AD.
authors.affiliation: Laboratory for Investigative Dermatology, Rockefeller University, New York, NY.
authors.forename: Shinji
authors.initials: S
authors.lastname: Noda
authors.affiliation: Laboratory for Investigative Dermatology, Rockefeller University, New York, NY.
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
authors.affiliation: Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: emma.guttman@mountsinai.org.
authors.forename: Emma
authors.initials: E
authors.lastname: Guttman-Yassky
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001685:Biological Factors / Q000627:therapeutic use*; D003872:Dermatitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy / Q000209:etiology; D057170:Translational Research, Biomedical
chemical_list: D000893:Anti-Inflammatory Agents; D001685:Biological Factors
keywords: IL-23; Psoriasis; T(H)17; T(H)2; T(H)22; atopic dermatitis; biologics; eczema