title: Thromboelastography in the evaluation of coagulation disorders in patients with sepsis.
abstract: OBJECTIVE
  Unbalanced hemostasis and disseminated intravenous coagulopathy serve as key participants in organ dysfunction and disability. In this study we evaluated the coagulation profiles of patients diagnosed with systemic inflammatory syndrome (SIRS)-sepsis and multiple organ dysfunction syndrome. We also researched coagulation in sepsis by comparing thromboelastography (TEG) data with those of nonsepsis patients to determine the usefulness of the TEG device.
  
  
  METHODS
  Data were collected from 55 anesthesiology and surgery intensive care unit (ICU) patients: 21 with SIRS-sepsis (Group S) and 34 patients without SIRS-sepsis (Group C). Blood samples were taken upon admission to the ICU (t1) and on day 3 of the ICU stay (t2). TEG data (R = reaction time, K = coagulation time, a = alpha angle, and MA = maximum amplitude) were recorded. TEG parameters were compared with routine coagulation and hemogram studies.
  
  
  RESULTS
  The mean R value in Group C was higher than that of Group S at both t1 and t2. Group S had a significantly lower K value and higher alpha angle at t1 compared to Group C (P < 0.05).
  
  
  CONCLUSIONS
  Hypercoagulability was observed in SIRS-sepsis patients in the ICU, as measured with TEG. We believe that TEG will be a useful tool in the evaluation of coagulation disorders developing in septic critically ill patients.
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Kiliç
authors.forename: İsmet
authors.initials: İ
authors.lastname: Topçu
authors.forename: Hamza
authors.initials: H
authors.lastname: Bambal
authors.forename: Melek
authors.initials: M
authors.lastname: Civi
mesh_terms: D001794:Blood Pressure; D002116:Calcitonin / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007362:Intensive Care Units; D019934:International Normalized Ratio; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D010100:Oxygen / Q000097:blood; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D011517:Prothrombin Time; D018805:Sepsis / Q000097:blood*; D013599:Systole; D013916:Thrombelastography; D019851:Thrombophilia / Q000097:blood*
chemical_list: D006454:Hemoglobins; D011498:Protein Precursors; D002116:Calcitonin; D010100:Oxygen