title: Angiotensin II receptor blockade and skeletal muscle metabolism in overweight and obese adults with elevated blood pressure.
abstract: OBJECTIVE
  Whether angiotensin II receptor blockade improves skeletal muscle fatty acid oxidation in overweight and obese humans is unknown. The purpose of the study was to test the hypothesis that the angiotensin II receptor blocker, olmesartan, would increase fatty acid oxidation and the activity of enzymes associated with oxidative metabolism in skeletal muscle of overweight and obese humans.
  
  
  METHODS
  A total of 12 individuals (6 men and 6 women) aged 18-75 and with a body mass index ⩾25 kg/m2 were assigned to olmesartan or placebo for 8 weeks in a crossover fashion. Fatty acid oxidation was measured before and after each intervention by counting the (14)CO2 produced from [1-(14)C] palmitic acid in skeletal muscle homogenates.
  
  
  RESULTS
  Fatty acid oxidation was not significantly different between treatment periods at baseline and post intervention. In addition, the enzyme activities of citrate synthase and β-hydroxyacyl-coenzyme A dehydrogenase in skeletal muscle homogenates did not differ between treatment periods at baseline or post intervention.
  
  
  CONCLUSIONS
  Treatment with olmesartan for 8 weeks does not improve fatty acid oxidation or the activity of enzymes associated with oxidative metabolism in skeletal muscle from overweight and obese individuals. Taken together, our results indicate that improvements in skeletal muscle metabolism are not among the additional benefits of olmesartan that extend beyond blood pressure reduction.
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Nabil E
authors.initials: NE
authors.lastname: Boutagy
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Elaina L
authors.initials: EL
authors.lastname: Marinik
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, and The Metabolic Phenotyping Core Virginia Tech, Blacksburg, VA, USA.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: McMillan
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Angela S
authors.initials: AS
authors.lastname: Anderson
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, The Metabolic Phenotyping Core and the Fralin Translational Obesity Research Center, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Madlyn I
authors.initials: MI
authors.lastname: Frisard
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, and the Fralin Translational Obesity Research Center, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Davy
authors.affiliation: Heart Specialists of Southwest Virginia, Christiansburg, VA, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Rivero
authors.affiliation: Department of Human Nutrition, Foods, and Exercise, The Metabolic Phenotyping Core and the Fralin Translational Obesity Research Center, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Davy
authors.affiliation: Wallace Hall, Room 338A; 295 West Campus Drive Blacksburg, VA 24061, USA hulvermw@vt.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Hulver
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D015992:Body Mass Index; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D013777:Tetrazoles / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D005227:Fatty Acids; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan
keywords: angiotensin II receptor blockade; obesity; skeletal muscle metabolism