title: A 15-year old girl with asthma and lower lobe bronchiectasis.
abstract: Wet cough, wheeze, and sputum in an adolescent with evidence for bronchiectasis is an uncommon presentation. The differential diagnosis includes cystic fibrosis (CF), immunodeficiency disorders, complement deficiency, allergic bronchopulmonary aspergillosis, alpha-1 antitrypsin disease, repeated aspiration pneumonia, foreign body, bronchial carcinoid, unresolved right middle lobe pneumonia, and primary ciliary dyskinesia (PCD). The likely diagnosis proceeds from the more to less common in patients with these symptoms. The location of disease on computed tomography scanning, nasal and bronchial exhaled nitric oxide, identification of ultrastructural defects on electron microscopy, and specific genetic mutation help separate CF and PCD. Although differentiating these conditions is vital, the chronic management of the bronchiectasis usually includes clearance mechanisms, bronchodilators, regular exercise, appropriate vaccinations, and judicious antibiotics for airway infections.
authors.affiliation: Department of Internal Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Ricketti
authors.forename: David W
authors.initials: DW
authors.lastname: Unkle
authors.forename: Katherine A
authors.initials: KA
authors.lastname: King
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Cleri
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Ricketti
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis*; D001987:Bronchiectasis / Q000175:diagnosis*; D002925:Ciliary Motility Disorders / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed