title: Programming and inheritance of parental DNA methylomes in vertebrates.
abstract: 5-Methylcytosine (5mC) is a major epigenetic modification in animals. The programming and inheritance of parental DNA methylomes ensures the compatibility for totipotency and embryonic development. In vertebrates, the DNA methylomes of sperm and oocyte are significantly different. During early embryogenesis, the paternal and maternal methylomes will reset to the same state. Herein, we focus on recent advances in how offspring obtain the DNA methylation information from parents in vertebrates.
authors.affiliation: CAS Key Laboratory of Genomic and Precision Medicine, Being Institute of Genomics, CAS, Beijing, China; and.
authors.forename: Weimin
authors.initials: W
authors.lastname: Ci
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China liuj@big.ac.cn.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D000818:Animals; D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*
chemical_list: D044503:5-Methylcytosine