title: Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.
abstract: The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.
authors.affiliation: Radiochemistry Service and Cyclotron Operations, Cancer Biology and Radiology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.
authors.forename: Darpan N
authors.initials: DN
authors.lastname: Pandya
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pailloux
authors.forename: David
authors.initials: D
authors.lastname: Tatum
authors.forename: Darren
authors.initials: D
authors.lastname: Magda
authors.forename: Thaddeus J
authors.initials: TJ
authors.lastname: Wadas
mesh_terms: D000577:Amides / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007553:Isotope Labeling; D010795:Phthalic Acids / Q000737:chemistry; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000577:Amides; D002614:Chelating Agents; D056831:Coordination Complexes; D010795:Phthalic Acids; D019275:Radiopharmaceuticals; C011363:terephthalic acid; D015040:Zirconium