title: Human papillomavirus-related high-grade squamous intraepithelial lesions of the esophagus, skin, and cervix in an adolescent lung transplant recipient: a case report and literature review.
abstract: High-risk (carcinogenic) genotype human papillomavirus (HPV) infections can be associated with significant morbidity in the immunocompromised solid organ transplant (SOT) recipient. Immunosuppression-associated persistent infection can predispose to the development of rapidly progressive high-grade squamous intraepithelial lesions (HSIL) in this population. We present a case report of an adolescent bilateral lung transplant recipient who developed HSIL of the esophagus, cervix, and skin secondary to HPV. This review highlights the unique developmental needs of the sexually active adolescent SOT recipient and reviews guidelines for HPV-related screening and education of this population.
authors.affiliation: Division of Pulmonary/Pediatric Transplant Center, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: D
authors.initials: D
authors.lastname: Freiberger
authors.forename: L
authors.initials: L
authors.lastname: Lewis
authors.forename: L
authors.initials: L
authors.lastname: Helfand
mesh_terms: D002584:Cervix Uteri / Q000821:virology; D004947:Esophagus / Q000821:virology; D005260:Female; D005838:Genotype; D006801:Humans; D016867:Immunocompromised Host; D016040:Lung Transplantation / Q000009:adverse effects*; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000821:virology*; D011183:Postoperative Complications; D012867:Skin / Q000821:virology; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000175:diagnosis*; D066027:Transplant Recipients; D055815:Young Adult
keywords: adolescent; high-grade squamous intraepithelial lesions; human papillomavirus; immunosuppression; lung transplant; solid organ transplant