title: Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide.
abstract: A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.
authors.affiliation: Key Laboratory of Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
authors.forename: Xinjin
authors.initials: X
authors.lastname: Li
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Mingyou
authors.initials: M
authors.lastname: Hu
authors.forename: Limin
authors.initials: L
authors.lastname: Wang
authors.forename: Jinbo
authors.initials: J
authors.lastname: Hu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001965:Bromides; D007454:Iodides; D009942:Organometallic Compounds; D013454:Sulfoxides; C519478:trifluoromethylcopper; D003300:Copper