title: Are Extremes of Consumption in Eating Disorders Related to an Altered Balance between Reward and Inhibition?
abstract: The primary defining characteristic of a diagnosis of an eating disorder (ED) is the "disturbance of eating or eating-related behavior that results in the altered consumption or absorption of food" (DSM V; American Psychiatric Association, 2013). There is a spectrum, ranging from those who severely restrict eating and become emaciated on one end to those who binge and overconsume, usually accompanied by some form of compensatory behaviors, on the other. How can we understand reasons for such extremes of food consummatory behaviors? Recent work on obesity and substance use disorders has identified behaviors and neural pathways that play a powerful role in human consummatory behaviors. That is, corticostriatal limbic and dorsal cognitive neural circuitry can make drugs and food rewarding, but also engage self-control mechanisms that may inhibit their use. Importantly, there is considerable evidence that alterations of these systems also occur in ED. This paper explores the hypothesis that an altered balance of reward and inhibition contributes to altered extremes of response to salient stimuli, such as food. We will review recent studies that show altered sensitivity to reward and punishment in ED, with evidence of altered activity in corticostriatal and insula processes with respect to monetary gains or losses, and tastes of palatable foods. We will also discuss evidence for a spectrum of extremes of inhibition and dysregulation behaviors in ED supported by studies suggesting that this is related to top-down self-control mechanisms. The lack of a mechanistic understanding of ED has thwarted efforts for evidence-based approaches to develop interventions. Understanding how ED behavior is encoded in neural circuits would provide a foundation for developing more specific and effective treatment approaches.
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA ; Veterans Affairs San Diego Healthcare System , San Diego, CA , USA.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Wierenga
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Ely
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Bischoff-Grethe
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA ; Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Austria Medical University of Vienna , Vienna , Austria.
authors.forename: Ursula F
authors.initials: UF
authors.lastname: Bailer
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA ; Veterans Affairs San Diego Healthcare System , San Diego, CA , USA.
authors.forename: Alan N
authors.initials: AN
authors.lastname: Simmons
authors.affiliation: Department of Psychiatry, University of California San Diego , La Jolla, CA , USA.
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
keywords: anorexia nervosa; bulimia nervosa; cognitive control; eating disorders; gustatory processing; inhibition; reward processing