title: Percutaneous Irreversible Electroporation of a Large Centrally Located Hepatocellular Adenoma in a Woman with a Pregnancy Wish.
abstract: Irreversible electroporation (IRE) is a novel image-guided ablation technique that is rapidly gaining popularity in the treatment of malignant liver tumors located near large vessels or bile ducts. We describe a 28-year-old female patient with a 5 cm large, centrally located hepatocellular adenoma who wished to get pregnant. Regarding the risk of growth and rupture of the adenoma caused by hormonal changes during pregnancy, treatment of the tumor was advised prior to pregnancy. However, due to its central location, the tumor was considered unsuitable for resection and thermal ablation. Percutaneous CT-guided IRE was performed without complications and led to rapid and impressive tumor shrinkage. Subsequent pregnancy and delivery went uncomplicated. This case report suggests that the indication for IRE may extend to the treatment of benign liver tumors that cannot be treated safely otherwise.
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands, hj.scheffer@vumc.nl.
authors.forename: Hester J
authors.initials: HJ
authors.lastname: Scheffer
authors.forename: Marleen C A M
authors.initials: MC
authors.lastname: Melenhorst
authors.forename: Aukje A J M
authors.initials: AA
authors.lastname: van Tilborg
authors.forename: Karin
authors.initials: K
authors.lastname: Nielsen
authors.forename: Karin M
authors.initials: KM
authors.lastname: van Nieuwkerk
authors.forename: Richard A
authors.initials: RA
authors.lastname: de Vries
authors.forename: Petrousjka M P
authors.initials: PM
authors.lastname: van den Tol
authors.forename: Martijn R
authors.initials: MR
authors.lastname: Meijerink
mesh_terms: D018248:Adenoma, Liver Cell / Q000628:therapy*; D000328:Adult; D018274:Electroporation; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000628:therapy*; D011247:Pregnancy; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome