title: [Relationship between platelet specific antibodies and the onset, clinical manifestation, treatment and prognosis of ITP].
abstract: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. It is considered that production of platelet auto-antibodies was one of the pathogenesis of ITP, first-line therapy including corticosteroid and immunoglobulin could reduce destruction of platelets by inhibiting production of auto-antibodies and blocking Fc-receptor of reticuloendothelial system, but some of the patients were refractory to first-line therapy and have persistent duration of the disease, having worse prognosis and developing into chronic/refractory ITP(C/RITP) . Platelet membrane glycoprotein like GPIIb/IIIa and GPIbα are the most common antigen targets, but first-line therapy was less effective to patients whose anti-GPIbα antibodies are positive. Further studies revealed that the way causing platelet destruction by anti-GPIIb/IIIa antibodies and anti-GPIbα antibodies are different: the former is mainly dependent to Fc-pathway, and the latter mainly cleared platelet by Fc-independent way. Results above indicated that detection of type of platelet auto-antibodies maybe potential to treatment and prognosis of ITP. This article summarizes relationship between platelet specific antibodies and the onset, clinical manifestation, treatment and prognosis of ITP.
authors.affiliation: Hematology/Oncology Center, Beijing Key Laboratory of Pediatric Hematology/Oncology, National Key Discipline of Pediatrics, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Jing-Yao
authors.initials: JY
authors.lastname: Ma
authors.affiliation: Hematology/Oncology Center, Beijing Key Laboratory of Pediatric Hematology/Oncology, National Key Discipline of Pediatrics, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Zhen-Ping
authors.initials: ZP
authors.lastname: Chen
authors.affiliation: Hematology/Oncology Center, Beijing Key Laboratory of Pediatric Hematology/Oncology, National Key Discipline of Pediatrics, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. E-mail:runhuiwu@hotmail.com.
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Wu
mesh_terms: D000906:Antibodies / Q000276:immunology*; D001327:Autoimmune Diseases; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D010980:Platelet Membrane Glycoproteins; D011379:Prognosis; D013921:Thrombocytopenia / Q000276:immunology* / Q000628:therapy
chemical_list: D000906:Antibodies; D010980:Platelet Membrane Glycoproteins