title: Tumor deposits in head and neck carcinomas.
abstract: Tumor deposits, nodules in the peritumoral adipose tissue with no architectural residue of lymph node, have previously been described in colorectal adenocarcinomas. To date, however, there has been no examination of tumor deposits in head and neck squamous cell carcinoma (HNSCC).
  
  
  
  Neck dissection specimens of 140 patients with HNSCC were reevaluated for tumor deposits.
  
  
  
  Tumor deposits were detected in 24 cases (17%). Cases with tumor deposits had more lymphatic invasion (p = .007), higher pathological N classification (p = .00), and more frequently showed distant metastasis (p = .003). Disease-free and overall survival were significantly shorter for tumor deposit positive cases (p = .016 and p = .005, respectively). Only tumor deposits were significant for overall survival. Tumor deposits increased the risk of recurrent disease 2294 times. Tumor deposits and pericapsular invasion were identified as independent prognostic markers; tumor deposits increased the risk of death from disease 3.4 times, whereas pericapsular invasion was associated with a 2.2-fold increase in the risk of death.
  
  
  
  These results highlight the existence of tumor deposits in neck dissection specimens of HNSCC and their association with poor prognosis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E256-E260, 2016.
authors.affiliation: Department of Pathology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Sulen
authors.initials: S
authors.lastname: Sarioglu
authors.affiliation: Department of Pathology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Nilhan
authors.initials: N
authors.lastname: Akbulut
authors.affiliation: Department of Pathology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Selen
authors.initials: S
authors.lastname: Iplikci
authors.affiliation: Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
authors.forename: Barbaros
authors.initials: B
authors.lastname: Aydin
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Ersoy
authors.initials: E
authors.lastname: Dogan
authors.affiliation: Department of Pathology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Mehtat
authors.initials: M
authors.lastname: Unlu
authors.affiliation: Department of Preventive Oncology, Dokuz Eylul University, Institute of Oncology, Izmir, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Ellidokuz
authors.affiliation: Department of Radiodiagnostics, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Ada
authors.affiliation: Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
authors.forename: Fadime
authors.initials: F
authors.lastname: Akman
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Ahmet Omer
authors.initials: AO
authors.lastname: Ikiz
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D011379:Prognosis; D055815:Young Adult
keywords: head and neck; neck dissection; prognosis; squamous cell carcinoma; tumor deposit