title: Comparison of serum IL-1beta and C reactive protein levels in early diagnosis and management of neonatal sepsis.
abstract: Clinical signs and symptoms of non-infectious diseases are similar to those of infectious diseases during infancy. Therefore, rapid new methods for diagnosis of infections in infants are urgently needed. To examine the utility of measuring serum IL-1 beta for immediate diagnosis of sepsis in infants, in this cross-sectional epidemiological study blood samples were taken from 83 infants (41 female and 42 male) in whom infection was suspected and who were admitted to hospital. To perform serum interleukin (IL)-1 beta and quantitative C-reactive protein (CRP) tests, blood samples were placed in ice containers and delivered to the laboratory. The serum was removed from the samples at 4 degrees Celsius and stored in refrigerators at minus 30 degrees Celsius until the time of testing. The results were analysed by t tests. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of serum IL-1 beta were 27%, 71%, 25%, and 73%, respectively. Sensitivity, specificity, PPV and NPV of serum quantitative CRP were 76%, 60%, 40% and 88%, respectively. Hence quantitative serum CRP measurement for the diagnosis of infections is more efficient than measuring serum IL-1 beta levels. In general, quantitative serum CRP measurement as an alternative to other tests such as serum IL-1 beta assays might be an ideal test for diagnosing infections in infants.
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Parviz
authors.initials: P
authors.lastname: Ayazi
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Mahyar
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Daneshi
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Jahanihashemi
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Esmailzadehha
authors.affiliation: Department of Pediatric Infectious Diseases, Qazvin University of Medical Sciences; Department of Pediatrics, Qazvin University of Medical Sciences; Department of Laboratory Sciences, Qazvin University of Medical Sciences; Department of Biostatistics, Qazvin University of Medical Sciences; Metabolic Diseases Research Centre, Qazvin university of Medical Sciences; Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Negin
authors.initials: N
authors.lastname: Mosaferirad
mesh_terms: D016470:Bacteremia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D053583:Interleukin-1beta / Q000097:blood*; D007492:Iran / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D002097:C-Reactive Protein