title: Laparoscopic en bloc excision of gastrointestinal stromal tumors of the rectum after neoadjuvant imatinib therapy: anteriorly extended intersphincteric resection combined with partial resection of the prostate.
abstract: We herein present a novel technique for laparoscopic en bloc excision involving anteriorly extended intersphincteric resection with partial resection of the posterior lobe of the prostate for large rectal gastrointestinal stromal tumors (GISTs). The sequence of neoadjuvant imatinib therapy and this less invasive surgery for marginally resectable rectal GISTs has the potential to obviate the need for urinary reconstruction and permanent stomas without jeopardizing the tumor margin status.
authors.affiliation: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan, tueki@surg1.med.kyushu-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Ueki
authors.forename: K
authors.initials: K
authors.lastname: Nagayoshi
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: R
authors.initials: R
authors.lastname: Maeyama
authors.forename: A
authors.initials: A
authors.lastname: Yokomizo
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D013505:Digestive System Surgical Procedures / Q000379:methods*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate / Q000008:administration & dosage; D010535:Laparoscopy; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods; D011467:Prostate / Q000601:surgery*; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate