title: Bioactive chemical constituents from the brown alga Homoeostrichus formosana.
abstract: A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1-6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. ahui0220@yahoo.com.tw.
authors.forename: Hui-Yu
authors.initials: HY
authors.lastname: Fang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. uvaranichem@gmail.com.
authors.forename: Uvarani
authors.initials: U
authors.lastname: Chokkalingam
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. sfc@mail.nsysu.edu.tw.
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chiou
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan. htl@mail.cgu.edu.tw.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. slchen@kmu.edu.tw.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Department of Biology, National Changhua University of Education, Changhua 50007, Taiwan. wlwang@cc.ncue.edu.tw.
authors.forename: Wei-Lung
authors.initials: WL
authors.lastname: Wang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. sheu@mail.nsysu.edu.tw.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D016227:Benzoquinones / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D000459:Phaeophyceae / Q000737:chemistry* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D016227:Benzoquinones; C000601177:methylfarnesylquinone; D013481:Superoxides