title: Correlation between fundus autofluorescence and central visual function in chronic central serous chorioretinopathy.
abstract: OBJECTIVE
  To find possible correlations between the morphologic macular changes revealed by fundus autofluorescence (FAF) and the functional parameters such as visual acuity and retinal sensitivity in patients with chronic central serous chorioretinopathy (CSC).
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Forty-six eyes (39 consecutive patients) with chronic CSC were studied with FAF and microperimetry (MP). Retinal sensitivity value maps were exactly superimposed over FAF images. The following microperimetric parameters were applied: central 10-degree visual field, 4-2-1 strategy, 61 stimulation spots, white monochromatic background, stimulation time 200 ms, stimulation spot size Goldmann III. A possible relationship between MP and FAF was investigated.
  
  
  RESULTS
  Mean best-corrected visual acuity (BCVA) was 20/32 (median 20/25, range 20/20-20/200). BCVA was significantly correlated with FAF findings (Mann-Whitney test; P < .0001). A positive concordance between FAF and MP evaluation was also found (total concordance of 0.720 with a kappa of Cohen of 0.456). The hypo-autofluorescent areas showed decreased retinal sensitivity, while adjacent areas of increased FAF could be associated to both normal and decreased retinal sensitivity. Absolute scotoma, defined as 0 dB retinal sensitivity, corresponded with absence of autofluorescence.
  
  
  CONCLUSIONS
  Altered FAF in chronic CSC patients has a functional correlation quantified by microperimetry. This study confirms the impact of FAF changes on retinal sensitivity and their value to reflect the functional impairment in chronic CSC.
authors.affiliation: Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy; Fondazione per la Macula Onlus, Genova, Italy. Electronic address: ceandi@gmail.com.
authors.forename: Chiara M
authors.initials: CM
authors.lastname: Eandi
authors.affiliation: Fondazione per la Macula Onlus, Genova, Italy.
authors.forename: Felice Cardillo
authors.initials: FC
authors.lastname: Piccolino
authors.affiliation: Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Alovisi
authors.affiliation: Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Tridico
authors.affiliation: Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Giacomello
authors.affiliation: Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.
authors.forename: Federico M
authors.initials: FM
authors.lastname: Grignolo
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000503:physiopathology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D012607:Scotoma / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*