title: Allergic constitution theory of Chinese medicine and its assessment criterion and related studies.
abstract: Constitution factor plays an important role in the occurrence, development, and transformation of diseases. The occurrence of allergic diseases is mainly caused by the disorganized physiological function and suitability regulation of patients, except for their exposure to outside allergens. Moreover, it represents susceptibility and hypersensitivity to allergens. The current study expresses the concept of allergic constitution from the perspective of Chinese medicine (CM) and presents the criterion of allergic constitution. In addition, the distribution of allergic constitution in population, its factors, and its relation to health-related quality of life (HRQOL) were investigated. The HRQOL scores of allergic constitution were found to be lower than those of the Pinghe constitution. After making a study on the gene expression profile of allergic constitution, the characteristics of up-regulated or down-regulated genes were found. Finally, CM drug was researched and developed to improve allergic constitution. Based on clinical trials and animal experiments, CM is found to have good regulatory effects on allergic constitution.
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Ying-shuai
authors.initials: YS
authors.lastname: Li
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Ling-ru
authors.initials: LR
authors.lastname: Li
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China.
authors.forename: Yan-fei
authors.initials: YF
authors.lastname: Zheng
authors.affiliation: Center for Studies in Constitution Research of Traditional Chinese Medicine, Basic Medical School, Beijing University of Chinese Medicine, Beijing, 100029, China. wangqi710@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000235:genetics / Q000523:psychology / Q000628:therapy*; D008516:Medicine, Chinese Traditional
keywords: allergic constitution; criterion; epidemiological survey; gene expression; prevention and cure