title: Association of the NQO1 C609T polymorphism with Alzheimer's disease in Chinese populations: a meta-analysis.
abstract: Several molecular genetics studies have investigated the association of NQO1 C609T polymorphism with Alzheimer's disease (AD) susceptibility in Chinese populations; however, the findings are inconclusive. To investigate the association, we performed the present meta-analysis of 5 case-control studies (including 735 AD cases and 828 controls). We searched literature from PubMed, Embase, HuGNet and CNKI databases for eligible articles that evaluated the association between NQO1 C609T polymorphism and AD risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the strength of the association. Overall, C609T polymorphism was significantly associated with an increased AD risk (homozygote: OR = 1.87, 95% CI = 1.39-2.51, P = 0.000; heterozygote: OR = 1.93, 95% CI = 1.22-3.06, P = 0.019; dominant: OR = 1.97, 95% CI = 1.25-3.12, P = 0.004). When stratified by source of control, significant results were observed in subjects of population-based (PB), whereas no increased risk was observed among the hospital-based (HB). When stratified by APOEϵ4 carrier status, no effect of the NQO1 C609T polymorphism was seen in subjects of APOEϵ4 carriers and APOEϵ4 non-carriers. In conclusion, our results showed that NQO1 C609T polymorphism increases the risk of AD in Chinese populations. Larger studies with different ethnic populations are required to validate our findings.
authors.affiliation: a Department of Clinical Laboratory , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jingrong
authors.initials: J
authors.lastname: Luo
authors.affiliation: a Department of Clinical Laboratory , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: a Department of Clinical Laboratory , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.affiliation: a Department of Clinical Laboratory , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qiliu
authors.initials: Q
authors.lastname: Peng
authors.affiliation: a Department of Clinical Laboratory , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yanqiong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: c Department of Clinical Laboratory , Liuzhou People's Hospital , Liuzhou 545006, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Yang
authors.affiliation: d Department of Clinical Laboratory , Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Qin
authors.affiliation: e University of South China , Hengyang , China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: b Department of Geriatrics , First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4; D016660:NAD(P)H Dehydrogenase (Quinone)
keywords: Alzheimer's disease; NQO1 C609T; meta-analysis; polymorphism