title: [Papillomavirus vaccines: adverse effects].
abstract: BACKGROUND
  The Health Department of Catalunya laun- ched the first vaccination campaign against human papillo- mavirus (HPV) in the 2008-09 school year This study des- cribes the side effects of HPV vaccine and compared them with those of the vaccine against Hepatitis.
  
  
  METHODS
  This is a prospective observational study Nurses of our primary health centre went to the area's schools to administer the HPV vaccine and hepatitis vaccine (when necessary). Afterwards, between 24 to 72 hours, they went back to schools in order to control the adverse effects.
  
  
  RESULTS
  The frequency of general symptoms (syn- cope, fever, headache, muscle aches, malaise) was less than 5% with the first two doses. With the third, 9.8% of girls referred headache. Pain was the most common local symptom: 28.3% of girls reported pain with the first dose, 53.4% with the second and 53.6% with the third. Local reactions appear more often with HPV than with hepatitis vaccine, especially in the second and third doses (McNemar test p < 0.001).
  
  
  CONCLUSIONS
  HPV vaccine was generally well tolerated. General side effects were rare. Local symptoms were com- mon and increased with each new dose. The vaccine against hepatitis produced fewer side effects.
authors.affiliation: ABS 7 La Salut Badalona.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Bayés
authors.forename: Edith
authors.initials: E
authors.lastname: Valero
authors.forename: Edith Gil
authors.initials: EG
authors.lastname: Valero
authors.forename: Herance
authors.initials: H
authors.lastname: Gutiérrez
authors.forename: Antonia
authors.initials: A
authors.lastname: Martín Zafra
authors.forename: Inocencia
authors.initials: I
authors.lastname: Valverde Caballero
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Aizpurua Galdeano
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D053918:Papillomavirus Vaccines