title: Sex-based differences in skeletal muscle kinetics and fiber-type composition.
abstract: Previous studies have identified over 3,000 genes that are differentially expressed in male and female skeletal muscle. Here, we review the sex-based differences in skeletal muscle fiber composition, myosin heavy chain expression, contractile function, and the regulation of these physiological differences by thyroid hormone, estrogen, and testosterone. The findings presented lay the basis for the continued work needed to fully understand the skeletal muscle differences between males and females.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado.
authors.forename: K M
authors.initials: KM
authors.lastname: Haizlip
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado.
authors.forename: B C
authors.initials: BC
authors.lastname: Harrison
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado leslie.leinwand@colorado.edu.
authors.forename: L A
authors.initials: LA
authors.lastname: Leinwand
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism*; D012727:Sex Characteristics; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D018995:Myosin Heavy Chains