title: Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb.
abstract: The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
authors.forename: Yu-ichiro
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA; Department of Anatomy and Cell Biology, University of Kansas Medical Center 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA. Electronic address: MG2@stowers.org.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Gibson