title: New steroid derivative with hypoglycemic activity.
abstract: Data indicates that some steroid derivatives may induce changes on glucose levels; nevertheless, data are very confusing. Therefore, more pharmacological data are needed to characterize the activity induced by the steroid derivatives on glucose levels. The aim of this study was to synthesize a new steroid derivative for evaluate its hypoglycemic activity. The effects of steroid derivative on glucose concentration were evaluated in a diabetic animal model using glibenclamide and metformin as controls. In addition, the pregnenolone-dihydrotestosterone conjugate was bound to Tc-99m using radioimmunoassay methods, to evaluate the pharmacokinetics of the steroid derivative over time. The results showed that the pregnenolone-dihydrotestosterone conjugate induces changes on the glucose levels in similar form than glibenclamide. Other data showed that the biodistribution of Tc-99m-steroid derivativein brain was higher in comparison with spleen, stomach, intestine liver and kidney. In conclusion, the pregnenolone-dihydrotestosterone conjugate exerts hypoglycemic activity and this phenomenon could depend of its physicochemical properties which could be related to the degree of lipophilicity of the steroidderivative.
authors.affiliation: Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche Av. AgustínMelgar s/n, Col Buenavista C.P. 24039 Campeche Cam. México.
authors.forename: Figueroa-Valverde
authors.initials: FV
authors.lastname: Lauro
authors.affiliation: Escuela Nacional de Ciencias Biológicasdel Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas 11340 D.F. C.P. México.
authors.forename: Díaz-Cedillo
authors.initials: DC
authors.lastname: Francisco
authors.affiliation: Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche Av. AgustínMelgar s/n, Col Buenavista C.P. 24039 Campeche Cam. México.
authors.forename: Hau-Heredia
authors.initials: HH
authors.lastname: Lenin
authors.affiliation: Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche Av. AgustínMelgar s/n, Col Buenavista C.P. 24039 Campeche Cam. México.
authors.forename: García-Cervera
authors.initials: GC
authors.lastname: Elodia
authors.affiliation: Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche Av. AgustínMelgar s/n, Col Buenavista C.P. 24039 Campeche Cam. México.
authors.forename: Pool-Gómez
authors.initials: PG
authors.lastname: Eduardo
authors.affiliation: Facultad de Nutrición, Universidad Veracruzana Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México.
authors.forename: Rosas-Nexticapa
authors.initials: RN
authors.lastname: Marcela
authors.affiliation: Faculty of Medicine, University Autonomous of Campeche Av. Patricio Trueba de Regil s/n, Col Lindavista C.P. 24090 Campeche Cam. México.
authors.forename: Sarabia-Alcocer
authors.initials: SA
authors.lastname: Bety
keywords: Steroid; biodistribution; dihydrotestosterone; glucose