title: Acromegaly and aging: a comparative cross-sectional study.
abstract: OBJECTIVE
  Cognitive and functional geriatric assessment may change in acromegaly. Herein we aimed to determine at which points geriatric assessment of the cases with acromegaly differs from that of general elderly population.
  
  
  METHODS
  In this comparative cross-sectional study, a total of 30 cases with acromegaly (controlled n = 14, uncontrolled n = 16) and 30 gender and body-mass index-matched cases without acromegaly (control group, CG) above 60 years old were included. Cognitive functions were evaluated on the basis of the mini-mental state exam (MMSE). Affective status was determined using the geriatric depression scale. Activities of daily living (ADL) were ranked according to the Barthel index while instrumental activities of daily living (IADL) were graded on the basis of the Lawton scale. Nutritional status was evaluated using the mini-nutritional assessment (MNA). Body composition was measured through bioimpedance analysis. Functional mobility was determined using the Timed Up and Go test (TUG) and muscle strength with the handgrip strength test.
  
  
  RESULTS
  Scores on the MMSE were significantly lower in the elderly cases with acromegaly than in the cases without acromegaly (p < 0.001). Dementia was more frequent in the acromegaly group than in the CG (p = 0.04). Total MNA scores were significantly lower in cases with acromegaly than in the CG (p = 0.006). More subjects in the acromegaly group (33%) were at greater risk of malnutrition than in the CG (3%) (p = 0.003). There was greater moderate functional impairment based on Barthel ADL in the acromegaly group than in the CG (p = 0.04).
  
  
  CONCLUSIONS
  Acromegaly may impair cognitive functions, functional mobility and instrumental daily living activities in the geriatric population. With acromegaly, the risk of malnutrition may also increase.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey. Electronic address: esuheda@yahoo.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Hatipoglu
authors.affiliation: Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yuruyen
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Ela
authors.initials: E
authors.lastname: Keskin
authors.affiliation: Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Yavuzer
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Niyazoglu
authors.affiliation: Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Doventas
authors.affiliation: Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Deniz Suna
authors.initials: DS
authors.lastname: Erdincler
authors.affiliation: Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Tanju
authors.initials: T
authors.lastname: Beger
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: Sadi
authors.initials: S
authors.lastname: Gundogdu
mesh_terms: D000172:Acromegaly / Q000453:epidemiology*; D000203:Activities of Daily Living; D000368:Aged; D000375:Aging; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology*; D005260:Female; D015577:Geriatric Assessment; D018737:Hand Strength; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000453:epidemiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009752:Nutritional Status; D014421:Turkey / Q000453:epidemiology
keywords: Acromegaly; Aging; Cognitive functions; Dementia; Geriatrics; Malnutrition; Physical function; Sarcopenia