title: Efficient and practical synthesis of enantioenriched 2,3-dihydropyrroles through gold-catalyzed anti-Markovnikov hydroamination of chiral homopropargyl sulfonamides.
abstract: A direct gold-catalyzed 5-endo-dig cycloisomerization of chiral homopropargyl sulfonamides has been developed. A range of enantioenriched 2,3-dihydropyrroles are readily accessed by utilizing this approach. Importantly, this gold-catalyzed cycloisomerization reaction proceeds through an anti-Markovnikov addition by using a catalytic base as the additive, which completely suppresses the undesired dimerization.
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surfaces & The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, Fujian, P. R. China. longwuye@xmu.edu.cn.
authors.forename: Yong-Fei
authors.initials: YF
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Shu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Jian-Qiao
authors.initials: JQ
authors.lastname: Li
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Zhou
authors.forename: Long-Wu
authors.initials: LW
authors.lastname: Ye