title: [Fracture healing under intramedullary insertion of wires with hydroxyapatite coating].
abstract: OBJECTIVE
  To study morphological features of the bone formation process in consolidation of fractures of long tubular bones in conditions of intramedullary wires insertion with bioactive calcium-phosphate coating of hydroxyapatite.
  
  
  METHODS
  In experimental study in dogs was simulated open comminuted tibia fracture and performed intramedullary insertion of wires with hydroxyapatite coating. Using light and electron microscopy, using X-ray electron microprobe microanalyses were studied bone regenerates in 14-360 days after surgery.
  
  
  RESULTS
  It was found that around wires there is a formation of an area of active reparative bone formation and angiogenesis, bone shaped case with the properties of the conductor and inducer of osteogenesis. Fracture consolidation is carried out in the early stages of the primary type without formation of cartilage and connective tissue in the bone adhesion.
  
  
  CONCLUSIONS
  Study results testify that intramedullary wires with hydroxyapatite coating positively influence on the process and intensity of reparative bone formation in fracture healing.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Ir'ianov
authors.forename: N A
authors.initials: NA
authors.lastname: Kir'ianov
authors.forename: A V
authors.initials: AV
authors.lastname: Popkov
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology*; D005594:Fracture Fixation, Intramedullary / Q000295:instrumentation* / Q000379:methods; D017102:Fracture Healing / Q000187:drug effects*; D018460:Fractures, Comminuted / Q000601:surgery; D008422:Materials Testing / Q000379:methods; D013978:Tibial Fractures / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D017886:Durapatite