title: Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
abstract: Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz , 1156 High Street, Santa Cruz, California 95064, United States.
authors.forename: Brian
authors.initials: B
authors.lastname: León
authors.forename: Gabriel
authors.initials: G
authors.lastname: Navarro
authors.forename: Bailey J
authors.initials: BJ
authors.lastname: Dickey
authors.forename: George
authors.initials: G
authors.lastname: Stepan
authors.forename: Angela
authors.initials: A
authors.lastname: Tsai
authors.forename: Gregg S
authors.initials: GS
authors.lastname: Jones
authors.forename: Monica E
authors.initials: ME
authors.lastname: Morales
authors.forename: Tiffany
authors.initials: T
authors.lastname: Barnes
authors.forename: Shekeba
authors.initials: S
authors.lastname: Ahmadyar
authors.forename: Manuel
authors.initials: M
authors.lastname: Tsiang
authors.forename: Romas
authors.initials: R
authors.lastname: Geleziunas
authors.forename: Tomas
authors.initials: T
authors.lastname: Cihlar
authors.forename: Nikos
authors.initials: N
authors.lastname: Pagratis
authors.forename: Yang
authors.initials: Y
authors.lastname: Tian
authors.forename: Helen
authors.initials: H
authors.lastname: Yu
authors.forename: Roger G
authors.initials: RG
authors.lastname: Linington
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D005663:Furans / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry*; D011493:Protein Kinase C / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D017735:Virus Latency / Q000187:drug effects*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D005663:Furans; D056572:Histone Deacetylase Inhibitors; D061065:Polyketides; C509797:abyssomicin C; D011493:Protein Kinase C; C003422:tetronic acid