title: Determination of the content of residual solvents in Haikesu 2 by head-space gas chromatography.
abstract: OBJECTIVE
  To determine ethylacetate and petroleum ether(60-90 ℃)in Haikesu 2,which is one of the raw materials of artificial musk,using the head-space gas chromatography.
  
  
  METHODS
  The determination was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with an hydrogen flame ionization detector. The solvent was dimethyl sulfoxide and the internal standard was methanol. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The carrier gas was nitrogen. The containers of head-space injector were preheated at 90 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.
  
  
  RESULTS
  The results showed a good linear relationship for ethylacetate and petroleum ether(60-90 ℃)in their linearity range;and the limit of detection was 0.7 and 0.3 Μg/ml,respectively. The good precision and good average recoveries were satisfactory.
  
  
  CONCLUSIONS
  The head-space gas chromatography is simple,rapid,and precise technique for the measurement of residual solvents in Haikesu 2.
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Technology,Beijing Lianxin Pharmaceutic Co.,Ltd,Beijing 102628,China.
authors.forename: Ke-Min
authors.initials: KM
authors.lastname: Wang
authors.affiliation: Department of Technology,Shanghai Xing Ling Sci.& Tech. Pharmaceutical Co.,Ltd,Shanghai 201703,China.
authors.forename: Jia-Zhi
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Department of Technology,Beijing Lianxin Pharmaceutic Co.,Ltd,Beijing 102628,China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000085:Acetates / Q000032:analysis; D002849:Chromatography, Gas; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D005410:Flame Ionization; D012997:Solvents / Q000032:analysis*
chemical_list: D000085:Acetates; D004365:Drugs, Chinese Herbal; D005229:Fatty Acids, Monounsaturated; D012997:Solvents; C008563:musk; C007650:ethyl acetate