title: Role of secretory IgA in the mucosal sensing of commensal bacteria.
abstract: While the gut epithelium represents the largest mucosal tissue, the mechanisms underlying the interaction between intestinal bacteria and the host epithelium lead to multiple outcomes that remain poorly understood at the molecular level. Deciphering such events may provide valuable information as to the mode of action of commensal and probiotic microorganisms in the gastrointestinal environment. Potential roles of such microorganisms along the privileged target represented by the intestinal immune system include maturation processes prior, during and after weaning, and the reduction of inflammatory reactions in pathogenic conditions. As commensal bacteria are naturally coated by natural and antigen-specific SIgA in the gut lumen, understanding the consequences of such an interaction may provide new clues on how the antibody contributes to homeostasis at mucosal surfaces. This review discusses several aspects of the role of SIgA in the essential communication existing between the host epithelium and members of its microbiota.
authors.affiliation: a R&D Laboratory; Division of Immunology and Allergy; Center des Laboratoires d'Epalinges ; Epalinges , Switzerland.
authors.forename: Amandine
authors.initials: A
authors.lastname: Mathias
authors.forename: Bruno
authors.initials: B
authors.lastname: Pais
authors.forename: Laurent
authors.initials: L
authors.lastname: Favre
authors.forename: Jalil
authors.initials: J
authors.lastname: Benyacoub
authors.forename: Blaise
authors.initials: B
authors.lastname: Corthésy
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology; D018407:Bacterial Physiological Phenomena; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology*; D013559:Symbiosis
chemical_list: D007071:Immunoglobulin A, Secretory
keywords: DC, dendritic cell; IEC, intestinal epithelial cell; SC, secretory component; SED, subepithelial dome; SIgA, secretory IgA; dendritic cells; gut microbiota; intestinal epithelial cells; mucosal homeostasis; pIgR, polymeric Ig receptor; secretory IgA