title: MMN and P300 are both modulated by the featured/featureless nature of deviant stimuli.
abstract: OBJECTIVE
  This study was designed to test the effect of the featured/featureless nature of deviant stimuli on mismatch negativity (MMN), P300 (P3a and P3b) and on behavioral discrimination performances.
  
  
  METHODS
  Ten healthy adults were submitted to stimuli contrasted by the presence or absence of a frequency sweep. Discrimination performances were collected during the neurophysiological sessions.
  
  
  RESULTS
  MMN, P3a and P3b were much larger for featured deviants than for featureless ones. Behavioral data (d', at ceiling level, and reaction times) were not affected by the featured/featureless nature of the deviant stimulus.
  
  
  CONCLUSIONS
  Behavioral results and MMN amplitudes are in accordance with our previous study, using the same design albeit in an ignore condition and with collection of the behavioral data deferred until after the neurophysiological sessions. The present study strengthens previous evidence suggesting that two mechanisms contribute to the MMN evoked by featured deviants: the memory comparison process and the adaptation/fresh-afferent phenomenons.
  
  
  CONCLUSIONS
  We here demonstrate that the neurophysiological processes underlying P300 generation are also impacted by the featured/featureless nature of the deviant stimulus and that the dissociation from behavioral data, which are not impacted, is also observed when both types of data are recorded simultaneously.
authors.affiliation: Unité de Recherches en Neurosciences Cognitives, Centre for Research in Cognition and Neurosciences, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium; Laboratoire de Neurophysiologie Sensorielle et Cognitive, Université Libre de Bruxelles (U.L.B., CHU Brugmann), Brussels, Belgium; FNRS, Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Calcus
authors.affiliation: Unité de Recherches en Neurosciences Cognitives, Centre for Research in Cognition and Neurosciences, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium; Laboratoire de Neurophysiologie Sensorielle et Cognitive, Université Libre de Bruxelles (U.L.B., CHU Brugmann), Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Deltenre
authors.affiliation: Laboratoire de Neurophysiologie Sensorielle et Cognitive, Université Libre de Bruxelles (U.L.B., CHU Brugmann), Brussels, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Hoonhorst
authors.affiliation: Unité de Recherches en Neurosciences Cognitives, Centre for Research in Cognition and Neurosciences, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Collet
authors.affiliation: Laboratoire de Neurophysiologie Sensorielle et Cognitive, Université Libre de Bruxelles (U.L.B., CHU Brugmann), Brussels, Belgium; Institut Libre Marie Haps, Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Markessis
authors.affiliation: Unité de Recherches en Neurosciences Cognitives, Centre for Research in Cognition and Neurosciences, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium; Laboratoire de Neurophysiologie Sensorielle et Cognitive, Université Libre de Bruxelles (U.L.B., CHU Brugmann), Brussels, Belgium. Electronic address: ccolin@ulb.ac.be.
authors.forename: C
authors.initials: C
authors.lastname: Colin
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000328:Adult; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D055815:Young Adult
keywords: Auditory feature detection; Auditory sensory memory; Frequency modulation; Fresh-afferent hypothesis; Mismatch negativity; P300