title: Dynamic change of glomerular filtration rate in the early stage is associated with kidney allograft status: a preliminary report.
abstract: BACKGROUND
  This study aimed to investigate the relationship between the dynamic changes of estimated glomerular filtration rate (eGFR) in the early stage post renal transplantation and renal allograft dysfunction.
  
  
  METHODS
  We selected 9 patients with interstitial fibrosis and tubular atrophy (IF/TA) and 11 patients with stable renal function based on the Banff 2007 classification system. Pathology of the patients was evidenced with renal biopsy results. Glomerular filtration rate (GFR) was calculated continuously for 14 days post-transplantation by using an estimated GFR (eGFR) formula adjusted into Chinese. Linear regression was employed, and eGFR slopes were compared. Prisoners or organs from prisoners were not used in this study.
  
  
  CONCLUSIONS
  The eGFR slope in the IF/TA group was significantly higher than that in the stable group (P < 0.01), and a cut-off value of 5.11 mL/min/1.73 m(2)/d was a reliable clinical value in a receiver operating characteristic (ROC) curve. On the basis of the ROC area under the curve, predictive accuracy of the eGFR slope was excellent (0.848). In conclusion, the eGFR in IF/TA increased faster within a period of 14 days post-transplantation, suggesting that reperfusion in the early stage may damage the glomerular filtration membrane to some extent. Furthermore, reperfusion might adversely affect long-term renal allograft survival.
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. qi.guisheng@zs-hospital.sh.cn.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China. qi.guisheng@zs-hospital.sh.cn.
authors.forename: Guisheng
authors.initials: G
authors.lastname: Qi
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. tang.qunye@zs-hospital.sh.cn.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China. tang.qunye@zs-hospital.sh.cn.
authors.forename: Qunye
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. rong.ruiming@zs-hospital.sh.cn.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, People's Republic of China. rong.ruiming@zs-hospital.sh.cn.|Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. rong.ruiming@zs-hospital.sh.cn.
authors.forename: Ruiming
authors.initials: R
authors.lastname: Rong
mesh_terms: D000328:Adult; D064591:Allografts / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve