title: Silver nanoparticles: synthesis, properties, and therapeutic applications.
abstract: Silver nanoparticles (AgNPs) have been widely used in biomedical fields because of their intrinsic therapeutic properties. Here, we introduce methods of synthesizing AgNPs and discuss their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties. We also review the impact of AgNPs on human health and the environment along with the underlying mechanisms. More importantly, we highlight the newly emerging applications of AgNPs as antiviral agents, photosensitizers and/or radiosensitizers, and anticancer therapeutic agents in the treatment of leukemia, breast cancer, hepatocellular carcinoma, lung cancer, and skin and/or oral carcinoma.
authors.affiliation: School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
authors.forename: Liuya
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
authors.forename: Jingran
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Physics, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
authors.forename: Huizhong
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
authors.forename: Atish
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
authors.forename: Zhe-Sheng
authors.initials: ZS
authors.lastname: Chen
authors.affiliation: Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA. Electronic address: gfchen08@yahoo.com.
authors.forename: Guofang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D053768:Metal Nanoparticles / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D018570:Risk Assessment; D018030:Silver Compounds / Q000009:adverse effects / Q000138:chemical synthesis* / Q000627:therapeutic use*; D013499:Surface Properties; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D017319:Photosensitizing Agents; D011838:Radiation-Sensitizing Agents; D018030:Silver Compounds