title: [Content of some pro- and anti-inflammatory cytokines in blood sera of leptospirosis patients].
abstract: OBJECTIVE
  Study the content of some pro- and anti-inflammatory cytokines in blood sera of leptospirosis patients in dynamics of infectious process and the role of these cytokines in the disease immunopathogenesis.
  
  
  METHODS
  The content of cytokines in blood sera was determined by a method based on xMAP technology with a standard panel consisting of 9 analytes: TNF-α, MCP-1, IL-8, IL-4, IL-6, IL-10, IL-1Ra, IL-12 (p70), IFN-γ.
  
  
  RESULTS
  A significantly increased level of IL-8, IL-10, TNF-α was confirmed and the increased content of MCP-1 in leptospirosis patients compared with practically healthy donors was established for the first time. Correlations between cytokines during leptospirosis were detected.
  
  
  CONCLUSIONS
  The data obtained show that cytokines play an important role in leptospirosis immunopathogenesis.
authors.forename: O A
authors.initials: OA
authors.lastname: Petrova
authors.forename: N A
authors.initials: NA
authors.lastname: Stoianova
authors.forename: N K
authors.initials: NK
authors.lastname: Tokarevich
authors.forename: N A
authors.initials: NA
authors.lastname: Arsent'eva
authors.forename: N E
authors.initials: NE
authors.lastname: Liubimova
authors.forename: A V
authors.initials: AV
authors.lastname: Semenov
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D016207:Cytokines / Q000097:blood / Q000302:isolation & purification*; D006801:Humans; D007922:Leptospirosis / Q000097:blood* / Q000469:parasitology / Q000473:pathology
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016207:Cytokines