title: Transplantation: a brief history.
abstract: Developments in transplantation have progressed dramatically over the past century. Current research is underway to optimize immune modulation, genetically engineering animals for xenografting, and breakthroughs are occurring in regenerative medicine. However, pioneering live-donor transplantation has transformed transplantation in the organ shortage, and these contribute an increased proportion of transplanted organs. Live-donor transplantation is associated with better long-term outcomes, and techniques to recover organs have become less invasive. We set out to examine the evolution of transplantation from its historic beginnings to the developments that make it successful today.
authors.affiliation: From the Royal Free Hospital, London UK.
authors.forename: Joseph Yoav
authors.initials: JY
authors.lastname: Dangoor
authors.forename: David N
authors.initials: DN
authors.lastname: Hakim
authors.forename: Rajinder Pal
authors.initials: RP
authors.lastname: Singh
authors.forename: Nadey S
authors.initials: NS
authors.lastname: Hakim
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000266:history / Q000517:prevention & control; D006085:Graft Survival; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000266:history / Q000627:therapeutic use; D019520:Living Donors / Q000266:history* / Q000600:supply & distribution; D014180:Transplantation / Q000009:adverse effects / Q000266:history*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents