title: Application of prospective ECG-gated high-pitch 128-slice dual-source CT angiography in the diagnosis of congenital extracardiac vascular anomalies in infants and children.
abstract: OBJECTIVE
  To investigate the value of prospective ECG-gated high-pitch 128-slice dual-source CT (DSCT) angiography in the diagnosis of congenital extracardiac vascular anomalies in infants and children in comparison with transthoracic echocardiography (TTE).
  
  
  METHODS
  Eighty consecutive infants or children clinically diagnosed of congenital heart disease and suspected with extracardiac vascular anomaly were enrolled, and 75 patients were finally included in this prospective study. All patients underwent prospective ECG-gated high-pitch DSCT angiography after TTE with an interval of 1-7 days. The diagnostic accuracy and sensitivity of high-pitch DSCT angiography and TTE were compared according to the surgical/CCA findings. The image quality of DSCT was assessed using a five-point scale. The effective radiation dose (ED) was calculated.
  
  
  RESULTS
  A total of 17 congenital heart diseases and 162 separate extracardiac vascular anomalies were confirmed by surgical/CCA findings in 75 patients. The diagnostic accuracy of high-pitch DSCT angiography and TTE was 99.67% and 97.89%, respectively. The sensitivity of high-pitch DSCT angiography and TTE was 97.53% and 79.62%, respectively. There was significant difference regarding to the diagnostic accuracy and the sensitivity between high-pitch DSCT angiography and TTE (χ2 = 23.561 and 28.013, P<0.05). The agreement on the image quality scoring of DSCT between the two observers was excellent (κ = 0.81), and the mean score of image quality was 4.1±0.7. The mean ED of DSCT was 0.29±0.08 mSv.
  
  
  CONCLUSIONS
  Prospective ECG-gated high-pitch 128-slice DSCT angiography with low radiation dose and high diagnostic accuracy has higher sensitivity compared to TTE in the detection of congenital extracardiac vascular anomalies in infants and children.
authors.affiliation: Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Nie
authors.affiliation: Department of Nuclear Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: Guangjie
authors.initials: G
authors.lastname: Yang
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Ximing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Xu
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Haiou
authors.initials: H
authors.lastname: Li
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Cao
authors.affiliation: Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Ji
authors.affiliation: Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-Cerebral Vascular Diseases, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Cardiovascular Surgery, Shandong Provincial Hospital, Jinan, Shandong, China.
authors.forename: Anbiao
authors.initials: A
authors.lastname: Wang
mesh_terms: D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography / Q000379:methods; D004452:Echocardiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D011829:Radiation Dosage; D054079:Vascular Malformations / Q000175:diagnosis*