title: The association with Turner syndrome significantly affects the course of Hashimoto's thyroiditis in children, irrespective of karyotype.
abstract: Only few studies have investigated to now whether the association with Turner syndrome (TS) may affect the course of Hashimoto's thyroiditis (HT) in children. Aim of this study was to ascertain whether the presentation and long-term course of HT in TS children may be characterized by a peculiar and atypical pattern. The clinical and biochemical findings at HT diagnosis in 90 TS children (group A) were compared with those recorded in 449 girls with HT but without TS (group B); in group A patients, thyroid function tests were re-evaluated after a median time interval of 4.9 years. At HT diagnosis median TSH levels and the rate of cases presenting with a thyroid dysfunction picture were significantly lower in group A, irrespective of karyotype abnormalities. In group A only 34.8 % of the girls who had initially presented with euthyroidism remained euthyroid even at re-evaluation, whilst 67.7 % of those who had presented with subclinical hypothyroidism became overtly hypothyroid over time; also such evolutive pattern was irrespective of karyotype abnormalities. (1) In TS girls, HT presents with a milder hormonal pattern, which often deteriorates over time; (2) these biochemical features are not necessarily linked with a specific karyotype.
authors.affiliation: Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Aversa
authors.affiliation: Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Messina
authors.affiliation: Department of Pediatrics, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzanti
authors.affiliation: Pediatric Endocrinology Unit, Department of Translational Medical Sciences, University "Federico II" of Naples, Naples, Italy.
authors.forename: Mariacarolina
authors.initials: M
authors.lastname: Salerno
authors.affiliation: Department of Pediatrics, University of Turin, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mussa
authors.affiliation: Pediatrics Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'A. Moro', Bari, Italy.
authors.forename: Maria Felicia
authors.initials: MF
authors.lastname: Faienza
authors.affiliation: Department of Pediatrics, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Scarano
authors.affiliation: Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy. filippo.deluca@unime.it.
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
authors.affiliation: Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wasniewska
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications*; D006801:Humans; D059785:Karyotype; D014424:Turner Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics
keywords: Chromosomopathies; Hyperthyroidism; Overt hypothyroidism; Subclinical hypothyroidism; Thyroid autoimmune disease; Thyroid function patterns