title: A long-term, prospective, cohort study on the performance of right ventricular pacing leads: comparison of active-fixation with passive-fixation leads.
abstract: Active-fixation pacing leads allow the use of selective pacing sites. We evaluated their long-term performance versus passive-fixation leads in 199 newly implanted patients (n = 100 active and n = 99 passive). Postoperative pacing thresholds in the active group were higher than in the passive group (0.85 ± 0.31 V vs. 0.53 ± 0.21 V at baseline, P < 0.001). The active thresholds fell to 0.72 ± 0.23 V at 5 years with a significant drop at one month (0.68 ± 0.53 V, P = 0.003). The passive thresholds slightly increased to 0.72 ± 0.31 V at five years. Differences between groups were significant until three years (all P < 0.05). Active impedances were generally lower than passive impedances (600.44 ± 94.31Ω vs. 683.14 ± 110.98Ω at baseline), and both showed significant reductions at one month to 537.96 ± 147.43Ω in the active group, and after three months to 643.85 ± 82.40Ω in the passive group (both P < 0.01 vs. baseline). Impedance differences between groups were significant until four years (all P < 0.05). Adverse events included thresholds over 1 V, 5 of 6 active and 2 of 5 passive leads returned to below 1 V. One active left ventricular lead dislodged. One passive left subclavian lead insulation fracture occurred. Thus Active fixation pacing leads are stable in a five-year long-term follow up. There was no difference between active and passive leads in terms of electrical performance.
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Lie
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Cardiology, The Fifth Affliated Hospital of Sun Yet-Sen University, Zhuhai, 519000, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Shulin
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Dongli
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Qianhuan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Silin
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Guang zhou Overseas Chinese Hospital, Guang zhou 510632, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guang zhou 510080, China.
authors.forename: Huiqiang
authors.initials: H
authors.lastname: Wei
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial; D015331:Cohort Studies; D004567:Electrodes, Implanted; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011446:Prospective Studies; D012684:Sensory Thresholds