title: Changes of cytoskeleton affect T cell biological behaviors.
abstract: T lymphocyte (T cell) is a crucial member in adaptive immunity that protects the organism against foreign pathogens and cancer by producing cytokines and cytotoxic molecules. In T cell, the cytoskeleton is in a stable and dynamic renewed condition and maintains shape and mechanical resistance to deformation. The cytoskeleton changes lead to morphological differences of T cell, and then affect local mechanical properties and cellular behavior, including development, differentiation, polarization, migration or adhesion. In this review, we will discuss the effect of cytoskeleton changes on T cell biological behaviors and its mechanism.
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Tang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Linjie
authors.initials: L
authors.lastname: Ye
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Shao
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Jin
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Huang
authors.affiliation: School of Life Sciences, Northwestern Polytechnical University, 710072.
authors.forename: Junling
authors.initials: J
authors.lastname: Shi
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*