title: Associations between body mass index, ambulatory blood pressure findings, and changes in cardiac structure: relevance of pulse and nighttime pressures.
abstract: Ambulatory blood pressure monitoring (ABPM) is central in the management of hypertension. Factors related to BP, such as body mass index (BMI), may differently affect particular aspects of 24-hour ABPM profiles. However, the relevance of BMI, the most used index of adiposity, has been underappreciated in the determination of specific aspects of 24-hour ABPM profiles in hypertension. The authors evaluated the association between BMI and aspects of ABPM together with their associations with cardiac remodeling in 1841 patients. A positive association of BMI with 24-hour, daytime, and nighttime pulse pressure in untreated normal weight and overweight/obese hypertensive patients and a positive association of BMI with nocturnal BP parameters in treated overweight/obese hypertensive patients was observed. The clinical relevance of these findings was supported by the positive significant correlations of BMI-related BPs with left ventricular mass and atrial diameter.
authors.affiliation: Department of Clinical and Molecular Sciences, Internal Medicine and Geriatrics and "Hypertension Excellence Centre" of the European Society of Hypertension, University "Politecnica delle Marche", Ancona, Italy; Italian National Research Centre on Aging "U.Sestilli", IRCCS-INRCA, Ancona, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fedecostante
authors.forename: Francesco
authors.initials: F
authors.lastname: Spannella
authors.forename: Federico
authors.initials: F
authors.lastname: Giulietti
authors.forename: Emma
authors.initials: E
authors.lastname: Espinosa
authors.forename: Paolo
authors.initials: P
authors.lastname: Dessì-Fulgheri
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sarzani
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D002940:Circadian Rhythm / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology; D012189:Retrospective Studies; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents