title: Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats: Alleviation by taurine.
abstract: The aim of this study was to investigate the effects of taurine (TA) on serum lipid profiles following chronic coadministration of chlorpyrifos (CP) and lead acetate (Pb) in male Wistar rats. Fifty rats randomly distributed into five groups served as subjects. Distilled water (DW) was given to DW group, while soya oil (SO; 1 mL kg(-1)) was given to SO group. The TA group was treated with TA (50 mg kg(-1)). The CP + Pb group was administered sequentially with CP (4.25 mg kg(-1); 1/20th median lethal dose (LD50)) and Pb at 233.25 mg kg(-1) (1/20th LD50), while the TA + CP + Pb group received TA (50 mg kg(-1)), CP (4.25 mg kg(-1)), and Pb (233.25 mg kg(-1)) sequentially. The treatments were administered once daily by oral gavage for 16 weeks. The rats were euthanised, and the blood samples were collected at the termination of the study. Sera obtained from the blood samples were analyzed for total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde, and also the activities of serum antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase were analyzed. The low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and atherogenic index were calculated. The results showed that CP and Pb induced alterations in the serum lipid profiles and evoked oxidative stress. TA alleviated the disruptions in the serum lipid profiles of the rats partially by mitigating oxidative stress. It was concluded that TA may be used for prophylaxis against serum lipid disorders in animals that were constantly co-exposed to CP and Pb in the environment.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria gracjy8@yahoo.com.
authors.forename: Motunrayo G
authors.initials: MG
authors.lastname: Akande
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria.
authors.forename: Yusuf O
authors.initials: YO
authors.lastname: Aliu
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.
authors.forename: Suleiman F
authors.initials: SF
authors.lastname: Ambali
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria.
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Ayo
mesh_terms: D000818:Animals; D002374:Catalase / Q000097:blood; D004390:Chlorpyrifos / Q000097:blood / Q000633:toxicity*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D013654:Taurine / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D013654:Taurine; D007854:Lead; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D004390:Chlorpyrifos
keywords: Taurine; chlorpyrifos; lead; lipid disorders; oxidative stress; rats