title: New insights into lung development and diseases: the role of microRNAs.
abstract: MicroRNAs (miRNAs) are short endogenous noncoding RNA molecules (∼ 22 nucleotides) that can regulate gene expression at the post-transcription level. Research interest in the role of miRNAs in lung biology is emerging. MiRNAs have been implicated in a range of processes such as development, homeostasis, and inflammatory diseases in lung tissues and are capable of inducing differentiation, morphogenesis, and apoptosis. In recent years, several studies have reported that miRNAs are differentially regulated in lung development and lung diseases in response to epigenetic changes, providing new insights for their versatile role in various physiological and pathological processes in the lung. In this review, we discuss the contribution of miRNAs to lung development and diseases and possible future implications in the field of lung biology.
authors.affiliation: Departments of Surgery, Division of Pediatric Surgery, Pediatrics & Child Health and Physiology (adjunct), University of Manitoba and Biology of Breathing Theme, Manitoba Institute of Child Health, Winnipeg, Manitoba R3E 3P4, Canada.
authors.forename: Dina
authors.initials: D
authors.lastname: Johar
authors.forename: Vinayakumar
authors.initials: V
authors.lastname: Siragam
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mahood
authors.forename: Richard
authors.initials: R
authors.lastname: Keijzer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008168:Lung / Q000196:embryology*; D008171:Lung Diseases / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: diagnostic tools; développement pulmonaire; epigenetic regulation; lung development; lung diseases; maladies pulmonaires; micro ARN; microRNA; outils diagnostiques; régulation épigénétique; stratégies thérapeutiques; therapeutic strategies