title: Schizotypy from a developmental perspective.
abstract: The schizotypy construct focuses attention on the liability to develop schizophrenia-spectrum disorders, yet traditionally, the schizotypy models have put more emphasis on stress-vulnerability interactions rather than developmental dynamics of emerging risk for psychopathology. Indeed, developmental accounts of this emerging personality trait have rarely been explicitly formulated. In this position article, we wish to convey some of the basic developmental tenets of schizotypy, and how they can inform high-risk research. Firstly, we tackle the state vs trait issue to outline the possible relationship between high-risk states and trait schizotypy. Second, we review the evidence suggesting that the consolidation of schizotypy, encompassing its 3 main dimensions, could be considered as a developmental mediator between very early risk factors and transition into high-risk states. Importantly, developmental dynamics between endophenotypes, as well as transactional and epigenetics mechanisms should enter modern conceptualizations of schizotypy. Finally, we present a developmental psychopathology perspective of schizotypy sensitive to both the multifinality and equifinality of schizophrenia-spectrum disorders. We conclude that schizotypy represents a crucial construct in a fully-developmental study of schizophrenia-spectrum disorders.
authors.affiliation: martin.debbane@unige.ch.
authors.forename: Martin
authors.initials: M
authors.lastname: Debbané
authors.forename: Neus
authors.initials: N
authors.lastname: Barrantes-Vidal
mesh_terms: D018450:Disease Progression; D004198:Disease Susceptibility / Q000503:physiopathology*; D058068:Endophenotypes; D006801:Humans; D010553:Personality Development; D012569:Schizotypal Personality Disorder / Q000503:physiopathology*
keywords: developmental; high-risk; personality; psychopathology; psychosis; schizophrenia