title: Differing effects of resibufagenin on cinobufatalin- versus marinobufagenin-induced preeclampsia in a rodent model.
abstract: OBJECTIVE
  Previous studies from this laboratory have demonstrated that the bufodienolide, marinobufagenin, causes a syndrome in the pregnant rat that resembles human preeclampsia. Furthermore, marinobufagenin urinary excretion is elevated in approximately 85% of preeclamptic patients. Resibufagenin, an antagonist to marinobufagenin, completely prevents the syndrome (hypertension, proteinuria, and intrauterine growth restriction) if given from early pregnancy.
  
  
  METHODS
  We investigated the effects of another bufodienolide, cinobufatalin, to determine if it, likewise, could induce the rat "preeclamptic" syndrome, which it did. We then examined whether resibufagenin could prevent the syndrome due to cinobufatalin.
  
  
  RESULTS
  Resibufagenin improved hypertension but not proteinuria, and did not prevent uterine growth restriction.
  
  
  CONCLUSIONS
  We conclude that more than one bufodienolide may induce the preeclamptic syndrome and that each may require a specific antagonist to prevent (or treat) the syndrome.
authors.affiliation: Texas A&M Colleges of Medicine and of Veterinary Medicine and Biomedical Sciences, Texas Veterinary Medical Center, College Station, Texas.
authors.forename: Jules B
authors.initials: JB
authors.lastname: Puschett
authors.affiliation: Scott and White Healthcare, Temple, Texas.
authors.forename: Biresh
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Texas A&M Colleges of Medicine and of Veterinary Medicine and Biomedical Sciences, Texas Veterinary Medical Center, College Station, Texas.
authors.forename: M M Kamran
authors.initials: MM
authors.lastname: Abbas
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000517:prevention & control*; D006973:Hypertension / Q000517:prevention & control*; D011225:Pre-Eclampsia / Q000139:chemically induced*; D011247:Pregnancy; D011507:Proteinuria / Q000517:prevention & control*; D051381:Rats
chemical_list: D002018:Bufanolides; C093896:marinobufagenin