title: Structure, physical properties, hemocompatibility and cytocompatibility of starch/zein composites.
abstract: A series of composite films were prepared from glycerol-plasticized starch and zein by intensive mixing and hot press. The structure and physical properties of the starch/zein (SZ) composite films were characterized by scanning electron microscope (SEM), optical microscopy and water contract angle testing. The hemocompatibility and cytocompatibility of SZ films were evaluated by plasma recalcification time, hemolysis assay and cell culture experiment. SEM and optical observation showed that starch and zein domains can be differed in the films and in a two phase separation status. Glycerol affects the surface hydrophilicity/hydrophobicity of the films. The hemocompatibility and cytocompatibility evaluation showed that SZ composites are anticoagulant materials with no hemolysis and low cytotoxicity. The SZ composites maybe have potentials for applications as biomaterials.
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Faculty of Life Science, Hubei University, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Medical Images, Gongan County People's Hospital, Gongan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Sheng
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China.
authors.forename: Yinping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Tong
authors.affiliation: Faculty of Life Science, Hubei University, Wuhan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ni
authors.affiliation: UMR 7365 CNRS - Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire, Biopôle, Vandœuvre-lès-Nancy, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Huselstein
authors.affiliation: UMR 7365 CNRS - Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire, Biopôle, Vandœuvre-lès-Nancy, France.
authors.forename: Xiong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Science, Wuhan University, Wuhan, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006461:Hemolysis / Q000187:drug effects*; D008420:Manufactured Materials / Q000032:analysis; D008422:Materials Testing; D051379:Mice; D018532:Pisum sativum / Q000737:chemistry; D011817:Rabbits; D013213:Starch / Q000737:chemistry*; D015028:Zein / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D013213:Starch; D015028:Zein
keywords: Starch; biomaterials; hot press; zein