title: The clinical utility of multimodal MR image-guided needle biopsy in cerebral gliomas.
abstract: OBJECTIVE
  Our aim was to evaluate the diagnostic value of multimodal Magnetic Resonance (MR) Image in the stereotactic biopsy of cerebral gliomas, and investigate its implications.
  
  
  METHODS
  Twenty-four patients with cerebral gliomas underwent (1)H Magnetic Resonance Spectroscopy ((1)H-MRS)- and intraoperative Magnetic Resonance Imaging (iMRI)-supported stereotactic biopsy, and 23 patients underwent only the preoperative MRI-guided biopsy. The diagnostic yield, morbidity and mortality rates were analyzed. In addition, 20 patients underwent subsequent tumor resection, thus the diagnostic accuracy of the biopsy was further evaluated.
  
  
  RESULTS
  The diagnostic accuracies of biopsies evaluated by tumor resection in the trial groups were better than control groups (92.3% and 42.9%, respectively, p = 0.031). The diagnostic yield in the trial groups was better than the control groups, but the difference was not statistically significant (100% and 82.6%, respectively, p = 0.05). The morbidity and mortality rates were similar in both groups.
  
  
  CONCLUSIONS
  Multimodal MR image-guided glioma biopsy is practical and valuable. This technique can increase the diagnostic accuracy in the stereotactic biopsy of cerebral gliomas. Besides, it is likely to increase the diagnostic yield but requires further validation.
authors.affiliation: a Glioma Surgery Division.|b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Yao
authors.affiliation: c Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
authors.forename: Shunzeng
authors.initials: S
authors.lastname: Lv
authors.affiliation: d Department of Neuropathology.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: e Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tang
authors.affiliation: f Neurological Surgery Department, First People's Hospital of Yancheng, Jiang Su Province, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: a Glioma Surgery Division.|b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Zhuang
authors.affiliation: g Department of Computer Science, Old Dominion University, Norfolk, VA, USA.
authors.forename: Nikos
authors.initials: N
authors.lastname: Chrisochoides
authors.affiliation: a Glioma Surgery Division.|b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Wu
authors.affiliation: b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.affiliation: b Department of Neurological Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005629:Frozen Sections; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005910:Glioma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D061705:Image-Guided Biopsy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D059906:Neuroimaging / Q000379:methods*; D015588:Observer Variation; D012189:Retrospective Studies; D016037:Single-Blind Method; D013238:Stereotaxic Techniques; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: MRS; biopsy; glioma; intraoperative MRI