title: Induced sputum is safe and well-tolerated for TB diagnosis in a resource-poor primary healthcare setting.
abstract: Improved tuberculosis (TB) diagnostics are required. Induced sputum sampling is superior to spontaneous sputum analysis for diagnosis of pulmonary TB. Therefore, we examined the applicability of induced sputum in primary health centers of the Peruvian TB program and studied the safety and tolerability of this procedure. We show that induced sputum is safe, inexpensive, and well-tolerated in a resource-limited environment. Widespread use of induced sputum at primary health centers can be implemented and may improve TB diagnosis.
authors.forename: Cesar
authors.initials: C
authors.lastname: Ugarte-Gil
authors.forename: Paul T
authors.initials: PT
authors.lastname: Elkington
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: Jon S
authors.initials: JS
authors.lastname: Friedland
authors.forename: David A J
authors.initials: DAJ
authors.lastname: Moore
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010568:Peru / Q000453:epidemiology; D011320:Primary Health Care / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage* / Q000009:adverse effects*; D013183:Sputum / Q000382:microbiology*; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D012462:Saline Solution, Hypertonic