title: [Neurosis and genetic theory of etiology and pathogenesis of ulcer disease].
abstract: Based on the analysis of literature data and our own research, we have developed the original concept of etiology and pathogenesis of peptic ulcer disease. An analysis of the literature shows that none of the theories of pathogenesis of peptic ulcer disease does not cover the full diversity of the involved functions and their shifts, which lead to the development of ulcers in the stomach and the duodenum. Our neurogenic-genetic theory of etiology and pathogenesis of gastric ulcer and duodenal ulcer very best explains the cause-and-effect relationships in the patient peptic ulcer, allowing options for predominance in one or the other case factors of neurosis or genetic factors. However, it is clear that the only other: combination of neurogenic factor with genetically modified reactivity of gastroduodenal system (the presence of the target organ) cause the chronicity of the sores. The theory of peptic ulcer disease related to psychosomatic pathologies allows us to develop effective schema therapy, including drugs with psychocorrective action. On the basis of our theory of the role of Helicobacter pylori infection is treated as a pathogenetic factor in the development of peptic ulcer disease.
authors.forename: M L
authors.initials: ML
authors.lastname: Kolotilova
authors.forename: L N
authors.initials: LN
authors.lastname: Ivanov
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D009497:Neurotic Disorders / Q000150:complications* / Q000503:physiopathology; D062072:Patient Acuity; D010437:Peptic Ulcer / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011602:Psychophysiologic Disorders; D011619:Psychotropic Drugs / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D011619:Psychotropic Drugs