title: Chiral primary amine catalyzed asymmetric Michael addition of malononitrile to α-substituted vinyl ketone.
abstract: The first efficient and highly enantioselective Michael addition-protonation reaction of malononitriles to α-substituted vinyl ketones has been developed by using a chiral primary amine as the organocatalyst. With a Hantzsch ester as the hydride source, an enantioselective tandem reduction, Michael addition-protonation reaction of benzylidenemalononitrile has also been achieved with good yields and high enantioselectivities.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.
authors.forename: Niankai
authors.initials: N
authors.lastname: Fu
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo