title: Dietary intake and ghrelin and leptin changes after sleeve gastrectomy.
abstract: BACKGROUND
  Surgical intervention in obesity is today the most effective treatment method in high level obesity management. Bariatric interventions not only ensure body weight reduction, but may influence dietary habits.
  
  
  OBJECTIVE
  To assess changes in adipose hormones and dietary habits in obese patients after sleeve gastrectomy.
  
  
  METHODS
  The study set comprised 37 subjects (29 females and 8 males) 24 to 68 years old with body mass index 43.0 ±4.9 kg/m(2). Pre-operative examination included baseline measurements of body composition. Dietary habits and intake frequency were monitored by a questionnaire method. Follow-up examinations were carried out in a scope identical to the pre-operative examination, 6 and 12 months after surgery, respectively.
  
  
  RESULTS
  The average patient weight loss 12 months after surgery was 31.7 kg. Excess weight loss was 55.2 ±20.6%. Patients reported reduced appetite (p < 0.001), increasingly regular food intake (p < 0.001), intake of more meal portions per day (p = 0.003) and a decrease in consuming the largest portions during the afternoon and evening (p = 0.030). Plasma levels of fasting glucose, leptin and ghrelin significantly decreased (p = 0.006; p = 0.0.043); in contrast, the level of adiponectin significantly increased (p < 0.001).
  
  
  CONCLUSIONS
  Sleeve gastrectomy and follow-up nutritional therapy resulted in a significant body weight reduction within 1 year after surgery. An improvement of certain dietary habits in patients was registered. At 12 months after surgery, there were no statistically significant differences in decreases in ghrelin and leptin concentrations between patients without changed appetite and those reporting decreased appetite.
authors.affiliation: Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Bužga
authors.affiliation: Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Vladislava
authors.initials: V
authors.lastname: Zavadilová
authors.affiliation: Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Pavol
authors.initials: P
authors.lastname: Holéczy
authors.affiliation: Department of Sciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Švagera
authors.affiliation: Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Pavol
authors.initials: P
authors.lastname: Švorc
authors.affiliation: Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Aleš
authors.initials: A
authors.lastname: Foltys
authors.affiliation: Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Zonča
keywords: bariatric surgery; dietary habits; dietary intake frequency; ghrelin; laparoscopic sleeve gastrectomy; leptin