title: Effect of bilateral supraclavicular postoperative radiotherapy in middle and lower thoracic esophageal carcinoma.
abstract: OBJECTIVE
  To evaluate whether postoperative radiotherapy is an alternative to neck lymph node surgery and if it provides a survival benefit for those receiving two-field, chest and abdomen, lymphadenectomy.
  
  
  METHODS
  A total of 530 cases with middle and lower thoracic esophageal carcinoma in our hospital from January 2008 to April 2009 were selected and analyzed, of which 219 cases received right chest, upper abdominal incision Ivor-Lewis surgery and simultaneously underwent mediastinal and abdominal two-field lymphadenectomy. If regional lymph node metastasis occurred within the recurrent laryngeal nerve, the patients would receive bilateral supraclavicular radiotherapy (DT = 5000cGy) to be adopted at postoperative 4-5 wk (Group A) or cervical lymphadenectomy at postoperative 3-4 wk (Group B). If there were no regional lymph node metastases within the recurrent laryngeal nerve, the patients only underwent two-field, chest and abdomen, lymphadenectomy (Group C).
  
  
  RESULTS
  In 219 cases who underwent two-field lymphadenectomy, 91 cases were diagnosed with regional lymph node metastasis within the recurrent laryngeal nerve. Of them, 48 cases received cervical radiotherapy, and 43 cases underwent staging lymphadenectomy; 128 patients were not given the follow-up treatment of cervical radiotherapy because there was no regional lymph node metastasis within the recurrent laryngeal nerve. Five-year survival rates in group A and B were 47% and 50%, respectively, with no statistical difference between them, and the rate in group C was 58%.
  
  
  CONCLUSIONS
  For patients with middle and lower thoracic esophageal carcinoma combined with lymph node metastasis within the recurrent laryngeal nerve, cervical radiotherapy can be a substitute for surgery and provide benefit.
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Su
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Yang
authors.affiliation: Yi Ren, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu, Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Dalian Medical University Clinical Oncology College, Shenyang 110042, Liaoning Province, China.
authors.forename: Yong-Yu
authors.initials: YY
authors.lastname: Liu
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D018450:Disease Progression; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal / Q000379:methods*; D012009:Recurrent Laryngeal Nerve / Q000473:pathology / Q000528:radiation effects*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: Bilateral supraclavicular postoperative radiotherapy; Lymph node metastasis; Middle and lower thoracic esophageal carcinoma