title: Unleashing mesenchymal chemotaxis.
abstract: In this issue of Developmental Cell, Asokan and colleagues (2014) report that the phospholipase Cγ (PLCγ)-diacyl glycerol (DAG) protein kinase Cα (PKCα) signaling axis inhibits actomyosin bundling. This preferentially occurs at the leading edge of chemotactic mesenchymal cells via noncanonical phosphorylation of the regulatory light chain (RLC) of nonmuscle myosin II.
authors.affiliation: Universidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: Aguilar-Cuenca
authors.affiliation: Universidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain. Electronic address: miguel.vicente@uam.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Vicente-Manzanares
mesh_terms: D000818:Animals; D002633:Chemotaxis / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000502:physiology*; D024462:Myosin Type II / Q000378:metabolism*; D051966:Phospholipase C gamma / Q000378:metabolism*; D051571:Protein Kinase C-alpha / Q000378:metabolism*
chemical_list: D051571:Protein Kinase C-alpha; D051966:Phospholipase C gamma; D024462:Myosin Type II