title: [Electronic cigarettes: A therapeutic tool, a social phenomenon or a business?].
abstract: Smoking is the first avoidable cause of morbidity and mortality. It is estimated that there were around 14 million smokers in France in 2012 and that smoking results in 70,000 deaths per year. All types of interventions reducing with efficacy the incidence and prevalence of smoking are to consider in prolonging life expectancy. Electronic cigarettes (e.cig.) are a social phenomenon but they also are a system delivering pharmacologically active substances; their use concerns today several millions of individuals in France. By this fact, it became important for clinical practitioners to acquire some knowledge about e. cig. Most of the e.cig. contains nicotine, thus, e.cig. are now called in the medical literature as electronic nicotine delivery system (ENDS). It is highly plausible that ENDS, which are, as of today, consumer products and not health products, deliver nicotine with a good bioavailability and could, if largely used, help to reduce smoking prevalence. However, because of current lack of regulations, as of today, the risk/benefit ratio of ENDS as an aid to help smokers quit and their adverse effect profile cannot be established. It is of public health responsibility to promote evidence based knowledge about e.cig. to know with confidence their risk/benefit ratio.
authors.affiliation: Inserm U 669, département de pharmacologie, hôpitaux universitaires La Pitié-Salpêtrière, Charles-Foix, faculté de médecine, université Pierre-et-Marie-Curie, 47, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: ivan.berlin@psl.aphp.fr.
authors.forename: I
authors.initials: I
authors.lastname: Berlin
mesh_terms: D066300:Electronic Nicotine Delivery Systems / Q000009:adverse effects*; D005602:France; D006801:Humans; D009538:Nicotine; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects*; D014029:Tobacco Use Disorder / Q000453:epidemiology* / Q000628:therapy
chemical_list: D009538:Nicotine
keywords: Aide au sevrage tabagique; Cigarettes électroniques; Electronic cigarettes; Rapport bénéfice/risque; Regulations; Risk/benefit ratio; Réglementation; Smoking cessation