title: Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases.
abstract: Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases.
authors.affiliation: Catholic High-Performance Cell Therapy Center & Department of Medical Lifescience; Department of Ophthalmology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 137-701, Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Jeon
authors.affiliation: Catholic High-Performance Cell Therapy Center & Department of Medical Lifescience, The Catholic University of Korea, Seoul 137-701, Korea.
authors.forename: Il-Hoan
authors.initials: IH
authors.lastname: Oh
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000166:cytology; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D051379:Mice; D009457:Neuroglia / Q000378:metabolism; D012038:Regeneration / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012162:Retinal Degeneration / Q000628:therapy*; D012164:Retinal Diseases / Q000628:therapy; D055213:Retinal Pigment Epithelium / Q000166:cytology; D033581:Stem Cell Transplantation / Q000379:methods*