title: Antidepressant-like effect of evodiamine on chronic unpredictable mild stress rats.
abstract: Evodiamine is a major alkaloid compound extracted from the dry unripened fruit Evodia fructus (Evodia rutaecarpa Benth., Rutaceae), which has a variety of pharmacological activities. The present study aims to determine the antidepressant-like effect of evodiamine in a rat model of chronic unpredictable mild stress (CUMS). We identified that evodiamine could reverse the following CUMS-induced behavioural deficits and biochemical changes in rats: the decreases of sucrose preference, number of crossings, 5-HT and NA levels, as well as the increase of immobility time. Evodiamine treatments also ameliorated the corticosterone hypersecretion induced by CUMS. Furthermore, we found that evodiamine was able to up-regulate the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated tropomyosin-related kinase B (pTrkB) without altering TrkB. This study suggests potential antidepressant-like effect of evodiamine on CUMS rats, and its underlying mechanisms can be potentially linked to their modulating effects on the monoamine transmitters and BDNF-TrkB signaling in the hippocampus.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Zhi-Xian
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yun-Zhan
authors.initials: YZ
authors.lastname: Li
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Zhuhai Natural Pharmaceuticals Ltd., High-tech Enterprise Zone, Zhuhai 519085, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China. Electronic address: gonggq@hotmail.com.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Gong
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010766:Phosphorylation; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D011799:Quinazolines; D012333:RNA, Messenger; D012701:Serotonin; C049639:evodiamine; D020813:Receptor, trkB; D003345:Corticosterone; D009638:Norepinephrine
keywords: Brain-derived neurotrophic factor; Chronic unpredictable mild stress; Depression; Evodiamine; Hippocampus; Tropomyosin-related kinase B