title: Isolation of a new flavanone from Daidai fruit and hypolipidemic activity of total flavonoids extracts.
abstract: In order to further discover the medicinal value of Daidai fruit, an exploration on the hypolipidemic activity of total flavonoids extracts of Daidai fruit (TFEODF) was conducted in high-fat diet-induced hyperlipemia rats. Results indicated that TFEODF exhibited significant hypolipidemic activity which resulted in the decline of serum total cholesterol, triglyceride, low density lipoprotein cholesterol, arteriosclerosis index and rise of high density lipoprotein cholesterol in hyperlipemia rats. For the purpose of expounding the chemical constituents of TFEODF, a phytochemical investigation of TFEODF was carried out for the first time. Research resulted in the isolation of a new compound together with 17 known compounds. This study lay a foundation for the development of a new hypolipidemic agent of traditional Chinese medicine whose chemical constituents were clarified.
authors.affiliation: a Pharmacy College, Fujian University of Traditional Chinese Medicine , Qiuyang Road No.1, Fuzhou Fujian 350122 , China.
authors.forename: Ling-Jun
authors.initials: LJ
authors.lastname: Zeng
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Qing-De
authors.initials: QD
authors.lastname: Huang
authors.forename: Qun
authors.initials: Q
authors.lastname: Huang
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Lian
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Cai
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Zeng
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Lin
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002957:Citrus / Q000737:chemistry*; D059305:Diet, High-Fat; D004365:Drugs, Chinese Herbal; D044950:Flavanones / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; C028610:flavanone
keywords: Daidai fruit; hypolipidemic; total flavonoids extracts