title: Nutrient-based dietary patterns and endometrial cancer risk: an Italian case-control study.
abstract: Diet has been suggested to have a role on endometrial cancer risk, but few data are available on the role of dietary patterns on this neoplasm. A case-control study was carried out in Italy, including 454 women with endometrial cancer and 908 hospital controls admitted to the same hospitals for acute, non-neoplastic diseases. Dietary information was based on a reproducible and valid food frequency questionnaire. A posteriori dietary patterns were obtained using principal component factor analysis on 28 nutrients. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from multiple logistic regression models conditioned on age and study center, and adjusted for major known confounding factors. Positive associations were found for the "Western-type diet" (OR=1.63, 95% CI: 1.12-2.38, for the highest versus the lowest quartile category) and the "Animal-derived nutrients and polyunsaturated fatty acids" patterns (OR=1.76, 95% CI: 1.23-2.52). The corresponding risk estimates among women with a body mass index ≥30 were 2.08 (95% CI: 0.92-4.69) and 2.30 (95% CI: 1.03-5.16) for the two patterns, respectively. No association was found for the other three patterns (i.e., "Vitamins and fiber", OR=0.96, 95% CI: 0.67-1.37, "Starch-rich", OR=0.99, 95% CI: 0.69-1.42, and "Other fats", OR=1.03, 95% CI: 0.70-1.52). This study indicates that dietary habits characterized by high intakes of animal products increase endometrial cancer risk, the association being appreciably stronger for obese women.
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bravi
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Bertuccio
authors.affiliation: Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Turati
authors.affiliation: Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, via F. Gallini, 2, 33080 Aviano, PN, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Edefonti
authors.affiliation: Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, via F. Gallini, 2, 33080 Aviano, PN, Italy.
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy; Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Adriano
authors.initials: A
authors.lastname: Decarli
authors.affiliation: Department of Epidemiology, Istituto Nazionale Tumori IRCCS - Fondazione Pascale, via M. Semmola, 80131 Naples, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.affiliation: Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, via F. Gallini, 2, 33080 Aviano, PN, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.affiliation: Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", via Giuseppe La Masa 19, 20156 Milan, Italy. Electronic address: cristina.bosetti@marionegri.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosetti
authors.affiliation: Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via G. Venezian, 1, 20122 Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Ferraroni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004032:Diet / Q000706:statistics & numerical data*; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D012306:Risk; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Case–control study; Diet; Dietary patterns; Endometrial cancer; Factor analysis