title: Characterization and preparation of bio-tubular scaffolds for fabricating artificial vascular grafts by combining electrospinning and a 3D printing system.
abstract: The last decade has seen artificial blood vessels composed of natural polymer nanofibers grafted into human bodies to facilitate the recovery of damaged blood vessels. However, electrospun nanofibers (ENs) of biocompatible materials such as chitosan (CTS) suffer from poor mechanical properties. This study describes the design and fabrication of artificial blood vessels composed of a blend of CTS and PCL ENs and coated with PCL strands using rapid prototyping technology. The resulting tubular vessels exhibited excellent mechanical properties and showed that this process may be useful for vascular reconstruction.
authors.affiliation: Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon 304-343, Republic of Korea. psa@kimm.re.kr.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Dong Nyoung
authors.initials: DN
authors.lastname: Heo
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Park
authors.forename: Seong Keun
authors.initials: SK
authors.lastname: Kwon
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Wan Doo
authors.initials: WD
authors.lastname: Kim
authors.forename: Il Keun
authors.initials: IK
authors.lastname: Kwon
authors.forename: Su A
authors.initials: SA
authors.lastname: Park
mesh_terms: D001187:Artificial Organs; D001672:Biocompatible Materials / Q000737:chemistry; D001808:Blood Vessels / Q000033:anatomy & histology / Q000502:physiology; D048271:Chitosan / Q000737:chemistry; D006801:Humans; D057139:Nanofibers / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D066330:Printing, Three-Dimensional; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan