title: Defining sarcopenia in terms of incident adverse outcomes.
abstract: OBJECTIVE
  The objectives of this study were to compare the performance of different diagnoses of sarcopenia using European Working Group on Sarcopenia in Older People, International Working Group on Sarcopenia, and the US Foundation of National Institutes of Health (FNIH) criteria, and the screening tool SARC-F, against the Asian Working Group for Sarcopenia consensus panel definitions, in predicting physical limitation, slow walking speed, and repeated chair stand performance, days of hospital stay and mortality at follow up.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  Community survey in Hong Kong.
  
  
  METHODS
  Participants were 4000 men and women 65 years and older living in the community.
  
  
  METHODS
  Information from questionnaire regarding activities of daily living, physical functioning limitations, and constituent questions of SARC-F; body mass index (BMI), grip strength (GS), walking speed, and appendicular muscle mass (ASM).
  
  
  RESULTS
  FNIH, consensus panel definitions, and the screening tool SARC-F all have similar AUC values in predicting incident physical limitation and physical performance measures at 4 years, walking speed at 7 years, days of hospital stay at 7 years, and mortality at 10 years. None of the definitions predicted increase in physical limitation at 4 years or mortality at 10 years in women, and none predicted all the adverse outcomes. The highest AUC values were observed for walking speed at 4 and 7 years.
  
  
  CONCLUSIONS
  When applied to a Chinese elderly population, criteria used for diagnosis of sarcopenia derived from European, Asian, and international consensus panels, from US cutoff values defined from incident physical limitation, and the SARC-F screening tool, all have similar performance in predicting incident physical limitation and mortality.
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address: jeanwoowong@cuhk.edu.hk.
authors.forename: Jean
authors.initials: J
authors.lastname: Woo
authors.affiliation: The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jason
authors.initials: J
authors.lastname: Leung
authors.affiliation: Divisions of Geriatric Medicine and Endocrinology, Saint Louis University School of Medicine, St. Louis, Missouri.
authors.forename: J E
authors.initials: JE
authors.lastname: Morley
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D018737:Hand Strength / Q000502:physiology*; D006723:Hong Kong; D006801:Humans; D057187:Independent Living; D008137:Longitudinal Studies; D008297:Male; D051346:Mobility Limitation; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology*; D018570:Risk Assessment; D055948:Sarcopenia / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D015996:Survival Rate; D013997:Time Factors; D016138:Walking / Q000502:physiology
keywords: Sarcopenia; appendicular muscle mass; grip strength; mortality; physical limitation; walking speed