title: A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma.
abstract: BACKGROUND
  The management of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) is controversial due to the early recurrence after curative hepatectomy, and many variables were related to the prognosis. The purpose of this study was to predict the tumor recurrence in early postoperative period of the patients with BCLC stage B HCC.
  
  
  METHODS
  From January 2004 to January 2012, 104 patients with BCLC stage B HCC underwent hepatectomy. Clinicopathological factors and follow-up data were statistically analyzed to establish a predicting scoring system.
  
  
  RESULTS
  The overall survival rates for one, three, and five years were 69.2%, 52.7%, and 42.3%, and the disease-free survival rates for one, three, and five years were 52.9%, 47.3%, and 37.5%, respectively. The multiple factors analysis showed that the micro-vessel invasion, lymph nodes metastasis, multiple lesions, and the high expression of HMGB1 were independent factors (P < 0.05). A scoring system was established to predict the early recurrence within one year after the surgery for BCLC stage B HCC, according to the analysis results with a specificity of 85.1% and a sensitivity of 80.3%.
  
  
  CONCLUSIONS
  Variant clinicopathological factors were associated with early postoperative recurrence for BCLC stage B HCC and recurrence early after hepatectomy was more likely in patients with a higher score of the scoring system.
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Honggang
authors.initials: H
authors.lastname: Qian
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wei
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Bonan
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Lyu
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Chengpeng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Jiahua
authors.initials: J
authors.lastname: Leng
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100142, China. Email: doctorhao@gmail.com.
authors.forename: Chunyi
authors.initials: C
authors.lastname: Hao
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D025741:HMGA1a Protein / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome
chemical_list: D025741:HMGA1a Protein