title: Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer.
abstract: The present study investigated the protein expression levels of cluster of differentiation (CD)95, caspase‑8, caspase‑3 and poly(ADP‑ribose) polymerase 1 (PARP1) in liver cancer and its association with clinical pathological parameters. The results demonstrated that the expression of CD95 correlated with histological differentiation, liver cirrhosis, lymph node metastasis and distant metastasis (P<0.05), however, no correlations with gender, age, quantity of tumor nodules or T stage were observed (P>0.05). The expression of CD95 was upregulated using a plasmid, which led to an increase in the expression levels of caspase‑8 and caspase‑3 and a decrease in the expression of PARP1. Upregulation of CD95 also promoted the apoptosis of the liver cancer cells. These results indicated that CD95 was associated with liver cancer and promoted the apoptosis of liver cancer cells by caspase‑8, caspase‑3 and PARP1.
authors.affiliation: Department of Pathology, Guilin Medical University, Guilin 541001, P.R. China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Kanglai
authors.initials: K
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Virology, National Laboratory of Antiviral and Tumor of Traditional Chinese Medicine, Institute of Medical Virology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University, Wuhan, Hubei 430056, P.R. China.
authors.forename: Qiongguang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Guilin Medical University, Guilin 541001, P.R. China.
authors.forename: Sien
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Pathology, Guilin Medical University, Guilin 541001, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Office of Graduate Student Affairs, Guilin Medical University, Guilin 541001, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan Economy and Technology Development Zone, Wuhan, Hubei 430056, P.R. China.
authors.forename: Lijiang
authors.initials: L
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D053181:Caspase 8 / Q000378:metabolism; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism*
chemical_list: D019014:fas Receptor; D011065:Poly(ADP-ribose) Polymerases; D053148:Caspase 3; D053181:Caspase 8