title: [Research advance on frozen injury and protective mechanisms of cryopreservated platelets].
abstract: Platelets are important component in the blood which play vital role in physiological hemostasis. In clinic, platelets are usually transfused to patients suffered from idiopathic thrombocytopenic purpura,thrombocytopenia after chemotherapy and radiotherapy,or hemorrhagic thrombocytopenia caused by other reasons. Storage time for platelet concentrates is limited to five days at room temperature, leading to an increasing number of scrap rate, therefore the prolonging the storage time is important for clinical application. Storage at -80°C is an ideal long-term cryopreservation method for platelet concentrates. In this article, platelets cryopreservation,the mechanism of frozen injury and the protective mechanisms of platelets were reviewed.
authors.affiliation: Beijing Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Yi
authors.affiliation: Beijing Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China. E-mail: Hanying-1001@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
mesh_terms: D001792:Blood Platelets; D001793:Blood Preservation; D015925:Cryopreservation; D005615:Freezing; D006487:Hemostasis; D006801:Humans; D013921:Thrombocytopenia