title: mAKAP-a master scaffold for cardiac remodeling.
abstract: Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogen-activated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy.
authors.affiliation: *Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; and †Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Passariello
authors.forename: Jinliang
authors.initials: J
authors.lastname: Li
authors.forename: Kimberly
authors.initials: K
authors.lastname: Dodge-Kafka
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kapiloff
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D020257:Ventricular Remodeling
chemical_list: D054758:A Kinase Anchor Proteins; C093173:AKAP6 protein, human