title: Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013.
abstract: BACKGROUND
  The purpose of this study was to determine the species distribution and to monitor the antifungal susceptibility profiles of clinical Candida isolates collected in China from 2009 to 2013.
  
  
  METHODS
  The antifungal susceptibilities of 952 Candida isolates were tested.
  
  
  RESULTS
  Candida albicans was the most common species, accounting for 65.7% of the total isolates. The most frequently isolated non-albicans Candida species in this study was Candida glabrata (193, 20.3%). Nearly 7.6%, 3.2%, 1.8%, and 1.1% of the 952 isolates exhibited decreased susceptibility to fluconazole, voriconazole, itraconazole, and flucytosine, respectively. Moreover, seven C. albicans and one Candida krusei had an amphotericin B minimum inhibitory concentration (MIC) of 2 μg/ml.
  
  
  CONCLUSIONS
  The distribution of species and the prevalence of antifungal resistance in Candida isolates varied among different areas in China. Continuous monitoring of resistance patterns is necessary to control the spread of resistance in clinical isolates of Candida species.
authors.affiliation: Department of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Pan
authors.affiliation: Department of Infectious Disease, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Anhui Centre for Surveillance of Bacterial Resistance, Hefei, China. Electronic address: biyoushenghua@sohu.com.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China; Department of Laboratory, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China. Electronic address: 98zl@sina.com.
authors.forename: Bao
authors.initials: B
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D002681:China; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006761:Hospitals; D006801:Humans; D007223:Infant; D017964:Itraconazole / Q000494:pharmacology; D008875:Middle Aged; D065819:Voriconazole / Q000494:pharmacology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D065819:Voriconazole
keywords: Antifungal susceptibility; Azoles; Candida species; Fluconazole