title: Breast DWI at 3 T: influence of the fat-suppression technique on image quality and diagnostic performance.
abstract: OBJECTIVE
  To evaluate two fat-suppression techniques: short tau inversion recovery (STIR) and spectral adiabatic inversion recovery (SPAIR) regarding image quality and diagnostic performance in diffusion-weighted imaging (DWI) of breast lesions at 3 T.
  
  
  METHODS
  Ninety-two women (mean age 48 ± 12.1 years; range 21-78 years) underwent breast MRI. Two DWI pulse sequences, with b-values (50 and 1000 s/mm(2)) were performed with STIR and SPAIR. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), suppression homogeneity, and apparent diffusion coefficient (ADC) values were quantitatively assessed for each technique. Values were compared between techniques and lesion type. Receiver operating characteristics (ROC) analysis was used to evaluate lesion discrimination.
  
  
  RESULTS
  One hundred and fourteen lesions were analysed (40 benign and 74 malignant). SNR and CNR were significantly higher for DWI-SPAIR; fat-suppression uniformity was better for DWI-STIR (p < 1 × 10(-4)). ADC values for benign and malignant lesions and normal tissue were 1.92 × 10(-3), 1.18 × 10(-3), 1.86 × 10(-3) s/mm(2) for DWI-STIR and 1.80 × 10(-3), 1.11 × 10(-3), 1.79 × 10(-3) s/mm(2) for SPAIR, respectively. Comparison between fat-suppression techniques showed significant differences in mean ADC values for benign (p = 0.013) and malignant lesions (p = 0.001). DWI-STIR and -SPAIR ADC cut-offs were 1.42 × 10(-3) and 1.46 × 10(-3) s/mm(2), respectively. Diagnostic performance for DWI-STIR versus SPAIR was: accuracy (81.6 versus 83.3%), area under curve (87.7 versus 89.2%), sensitivity (79.7 versus 85.1%), and specificity (85 versus 80%). Positive predictive value was similar.
  
  
  CONCLUSIONS
  The fat-saturation technique used in the present study may influence image quality and ADC quantification. Nevertheless, STIR and SPAIR techniques showed similar diagnostic performances, and therefore, both are suitable for use in clinical practice.
authors.affiliation: Department of Radiology, School of Health Technology of Porto/Polytechnic Institute of Porto (ESTSP/IPP), Rua Valente Perfeito, 4400-330, Vila Nova de Gaia, Portugal; Department of Radiology, Hospital de São João/Faculty of Medicine of Porto University (FMUP), Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address: mlpnogueira@med.up.pt.
authors.forename: Luisa
authors.initials: L
authors.lastname: Nogueira
authors.affiliation: MRI Unit, Department of Radiology, Hospital de São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Brandão
authors.affiliation: Institute of Biophysics and Biomedical Engineering (IBEB), Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016, Lisboa, Portugal.
authors.forename: Rita G
authors.initials: RG
authors.lastname: Nunes
authors.affiliation: Institute of Biophysics and Biomedical Engineering (IBEB), Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016, Lisboa, Portugal.
authors.forename: Hugo Alexandre
authors.initials: HA
authors.lastname: Ferreira
authors.affiliation: MRI Unit, Department of Radiology, Hospital de São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Loureiro
authors.affiliation: Department of Radiology, Hospital de São João/Faculty of Medicine of Porto University (FMUP), Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Ramos
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio; D055815:Young Adult
chemical_list: D003287:Contrast Media