title: The Scientific Revolution--The Kidney and Nephrology in and about the Seventeenth Century (Part 1).
abstract: In the history of the evolution of the medical sciences, it is in the 17th century that the conscious, deliberate, and systematic study of the workings of the human body began. It was a product of the radical changing attitudes of this insurgent century when mathematical reasoning and mechanistic philosophy replaced the teleological outlook of earlier times. It was then that meticulous observation, reproducible quantification, experimental validation, and mathematical exactitude in the quest for truths launched the Scientific Revolution. The effect on medicine was a transformative change from a descriptive to an explanatory body of knowledge during the course of which rigorous anatomical dissections were used for the mechanical explanation of organ function, when morbid changes observed at postmortem began to be related to clinical features of disease, and when the secretive analytical methods of alchemy began to be refined for the study of chemical changes in living matter. Essentially what began with meticulous observations of anatomical features begat physiology and laid the foundations of pathology and chemistry. As a result, studies of organ structure, function, and changes in disease in general, and of the kidney in particular, were clarified and progressed at a rate never achieved theretofore.
authors.affiliation: Renal Section, Department of Medicine, Baylor College of Medicine, Houston, Texas.
authors.forename: Garabed
authors.initials: G
authors.lastname: Eknoyan
mesh_terms: D049670:History, 17th Century; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D009398:Nephrology / Q000266:history*; D012586:Science