title: Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study.
abstract: OBJECTIVE
  The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes.
  
  
  METHODS
  We studied 318 mother-newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions.
  
  
  RESULTS
  Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95% confidence interval (CI) 4.8-45.3 mg/dl], and similar relations in palmitic (β = -581.8; 95 % CI -906.5, -257.0), oleic (β = -304.2; 95% CI -518.0, -90.5), linoleic (β = -348.6; 95% CI -510.6, -186.6), and α-linolenic (β = -6.3; 95% CI -9.5, -3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference.
  
  
  CONCLUSIONS
  Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.
authors.affiliation: Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Jia
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Harada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tagawa
authors.forename: Hisao
authors.initials: H
authors.lastname: Naito
authors.forename: Yumi
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Husna
authors.initials: H
authors.lastname: Yetti
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.forename: Seiko
authors.initials: S
authors.lastname: Sasaki
authors.forename: Atsuko
authors.initials: A
authors.lastname: Araki
authors.forename: Chihiro
authors.initials: C
authors.lastname: Miyashita
authors.forename: Tamiko
authors.initials: T
authors.lastname: Ikeno
authors.forename: Reiko
authors.initials: R
authors.lastname: Kishi
authors.forename: Tamie
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004051:Diethylhexyl Phthalate / Q000031:analogs & derivatives* / Q000097:blood; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D047929:Term Birth; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D005227:Fatty Acids; D014280:Triglycerides; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate