title: Economic evaluation of elective single-embryo transfer with subsequent single frozen embryo transfer in an in vitro fertilization/intracytoplasmic sperm injection program.
abstract: OBJECTIVE
  To analyze the cost-effectiveness of IVF-ICSI cycles with elective single-embryo transfer (eSET), plus elective single frozen embryo transfer (eSFET) if pregnancy is not achieved, compared with double-embryo transfer (DET).
  
  
  METHODS
  Cost-effectiveness analysis.
  
  
  METHODS
  Public hospital.
  
  
  METHODS
  A population of 121 women (<38 years old), undergoing their first or second IVF cycles.
  
  
  METHODS
  We conducted a cost-effectiveness analysis using the results of a prospective clinical trial. The women in group 1 received eSET plus eSFET, and those in group 2 received DET. A probabilistic sensitivity analysis was performed.
  
  
  METHODS
  Live birth delivery rate.
  
  
  RESULTS
  The cumulative live birth delivery rate was 38.60% in the eSET+eSFET group versus 42.19% in the DET group. The mean costs per patient were €5,614.11 in the eSET+eSFET group and €5,562.29 in the DET group. These differences were not statistically significant. The rate of multiple gestation was significantly lower in the eSET group than in the DET group (0 vs. 25.9%).
  
  
  CONCLUSIONS
  This study does not show that eSET is superior to DET in terms of effectiveness or of costs. The lack of superiority of the results for the eSET+eSFET and the DET groups corroborates that the choice of strategy to be adopted should be determined by the context of the health care system and the individual prognosis.
authors.affiliation: Department of International and Spanish Economics, University of Granada, Granada, Spain; University Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Hernandez Torres
authors.affiliation: Department of International and Spanish Economics, University of Granada, Granada, Spain; University Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Navarro-Espigares
authors.affiliation: U. Reproducción, UGC de Obstetricia y Ginecología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Granada, Spain; UGC Laboratorio Clínico, Hospital Universitario Virgen de las Nieves, Granada, Spain. Electronic address: anaclaverogilabert@gmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Clavero
authors.affiliation: U. Reproducción, UGC de Obstetricia y Ginecología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
authors.forename: MaLuisa
authors.initials: M
authors.lastname: López-Regalado
authors.affiliation: Department of International and Spanish Economics, University of Granada, Granada, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Camacho-Ballesta
authors.affiliation: UGC Medicina Preventiva, Vigilancia y Promoción de la Salud, Hospital Universitario Virgen de las Nieves, Granada, Spain.
authors.forename: MaÁngeles
authors.initials: M
authors.lastname: Onieva-García
authors.affiliation: U. Reproducción, UGC de Obstetricia y Ginecología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez
authors.affiliation: U. Reproducción, UGC de Obstetricia y Ginecología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Granada, Spain; UGC Laboratorio Clínico, Hospital Universitario Virgen de las Nieves, Granada, Spain; Banco de Semen CEIFER, Granada, Spain; Centro Masvida Reproducción, Seville, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Castilla
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D017558:Elective Surgical Procedures; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics* / Q000379:methods; D005615:Freezing; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D018873:Pregnancy Rate; D056826:Single Embryo Transfer / Q000191:economics* / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic / Q000191:economics*; D055815:Young Adult
keywords: Economic evaluation; assisted reproduction; probabilistic sensitivity analysis; single-embryo transfer