title: [Effects of ischemic postconditioning in patients with acute myocardial infarction undergoing primary PCI: a review and meta-analysis].
abstract: OBJECTIVE
  To evaluate the cardiac protective effects of ischemic postconditioning (IPC) in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  Both foreign and Chinese databases including PubMed, EMbase, Cochrane library, and CNKI were searched to identify randomized controlled trials (RCTs) that reported the effects of IPC on the myocardial infarction size, myocardial blush grade (MBG), left ventricular ejection fraction (LVEF) and major adverse cardiac events (MACE). Two reviews assessed the quality of each trial and extracted data independently. The Cochrane Collaboration's RevMan 4.2.8 software was used for statistical analysis.
  
  
  RESULTS
  Twelve studies were identified and the Meta-analysis included a total of 937 patients with AMI undergoing primary PCI with or without IPC. Pooled analysis of all studies demonstrated no significant reductions of peak CK and CK-MB with IPC relative to standard care. A secondary analysis of the studies didn't show improvements of left ventricular ejection fraction during hospitalization with IPC. However, the incidence of MACE within 3 month after primary PCI in IPC group was less than that in the control group (P = 0.04).
  
  
  CONCLUSIONS
  No significant benefit of IPC for reduction of myocardial infarct size as determined by peak creatine kinase and CK-MB release, as well as LVEF. The incidence of MACE was improved in patients who received IPC.
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. Email: fuxh999@hotmail.com.
authors.forename: Xianghua
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Xinshun
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Geng
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D006801:Humans; D057775:Ischemic Postconditioning; D009203:Myocardial Infarction; D009206:Myocardium; D062645:Percutaneous Coronary Intervention; D016277:Ventricular Function, Left