title: Review fifteen years of search for strong nucleosomes.
abstract: Don Crothers, Mikael Kubista, Jon Widom, and their teams have been first to look for strong nucleosomes, in a bid to reveal the nucleosome positioning pattern(s) carried by the nucleosome DNA sequences. They were first to demonstrate that the nucleosome stability correlates with 10-11 base sequence periodicity, and that the strong nucleosomes localize preferentially in centromeres. This review describes these findings and their connection to recent discovery of the strong nucleosomes (SNs) with visibly periodic nucleosome DNA sequences.
authors.affiliation: Institute of Evolution, University of Haifa, Haifa, Israel.
authors.forename: Edward N
authors.initials: EN
authors.lastname: Trifonov
authors.affiliation: Institute of Evolution, University of Haifa, Haifa, Israel.
authors.forename: Reshma
authors.initials: R
authors.lastname: Nibhani
mesh_terms: D002503:Centromere / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA
chemical_list: D002843:Chromatin; D009707:Nucleosomes
keywords: centromeres; chromatin code; chromatin structure; nucleosome positioning; nucleosome stability