title: Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia.
abstract: Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.
authors.affiliation: Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences Little Rock, Arkansas ; Division of Hematology and Oncology, Central Arkansas Veterans Healthcare System Little Rock, Arkansas.
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Xiang
authors.affiliation: Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences Little Rock, Arkansas.
authors.forename: Varinder
authors.initials: V
authors.lastname: Kaur
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences Little Rock, Arkansas.
authors.forename: Ibrahim K
authors.initials: IK
authors.lastname: Aburiziq
authors.affiliation: Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences Little Rock, Arkansas ; Division of Hematology and Oncology, Central Arkansas Veterans Healthcare System Little Rock, Arkansas.
authors.forename: Paulette
authors.initials: P
authors.lastname: Mehta
authors.affiliation: Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences Little Rock, Arkansas.
authors.forename: Peter
authors.initials: P
authors.lastname: Emanuel
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences Little Rock, Arkansas ; Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System Little Rock, Arkansas.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Schichman
keywords: Acute myeloid leukemia; chronic myelomonocytic leukemia; clonality; gene sequencing; genetic abnormality