title: [Endogenous intoxication and biochemical protection in children with celiac disease: state assesment and correlation-regression analysis].
abstract: OBJECTIVE
  The purpose of the study was to determine the characteristics of endogenous intoxication parameters, biochemical protection and reveal their interaction in children with celiac disease.
  
  
  METHODS
  81 children aged from 1 to 16 years with celiac disease were examined in acute and remission periods. In erythrocytes, blood serum and urine we determined low and moderate molecular weight substances (LMMWS), oligopeptides OP); in erythrocytes--the value of erythrocyte mechanical hemolysis (MH), malondialdehyde (MDA) content, the activity of glutathione reductase GR) and superoxide dismutase (SOD); in blood serum--ceruloplasmin (CP) level, alcohol dehydrogenase (ADH) activity; in erythrocytes and blood serum--glutathione transferase (GT), and calculated intoxication index (II).
  
  
  RESULTS
  In children with celiac disease in acute and remission periods LMMWS, OP, II levels in blood were statistically significantly high, while LMMWS level in urine was low. In both periods MH activity was high (p < 0.001), and GSR (p < 0.001) and SOD (p < 0.01) levels were low. We revealed the correlation between MDA and II (r = 0.67; p = 0.006), erythrocyte LMMWS and SOD (r = -0.61; p = 0.015), erythrocyte LMMWS and ADH (r = 0.62; p = 0.006), between GT and OP in urine (r = -0.31; p = 0.026), GTand MDA (r = 0.68; p = 0.000), GT and MH (r = -0.46; p = 0.004), between MDA and CP (r = 0.57; p = 0.002) that made it possible to develop the models of dependence of the parameters in relation to each other.
  
  
  CONCLUSIONS
  In celiac disease there is endogenous intoxication. The changes of the first and the second phases of biotransformation, antioxidant protection is an essential factor of the disease pathogenesis, since they have an effect on endogenous intoxication formation that should be taken into consideration in therapy.
authors.forename: I D
authors.initials: ID
authors.lastname: Uspenskaia
authors.forename: E I
authors.initials: EI
authors.lastname: Shabunina
authors.forename: E A
authors.initials: EA
authors.lastname: Zhukova
authors.forename: M V
authors.initials: MV
authors.lastname: Erzutova
authors.forename: L V
authors.initials: LV
authors.lastname: Korkotashvili
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002446:Celiac Disease / Q000097:blood / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D002570:Ceruloplasmin / Q000378:metabolism; D002648:Child; D055050:Diet, Gluten-Free / Q000379:methods; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008297:Male; D050216:Metabolic Detoxication, Phase I; D050217:Metabolic Detoxication, Phase II; D018384:Oxidative Stress; D012044:Regression Analysis; D012720:Severity of Illness Index; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D002570:Ceruloplasmin; D005980:Glutathione Reductase; D005982:Glutathione Transferase