title: A general metal-free approach for the stereoselective synthesis of C-glycals from unactivated alkynes.
abstract: A novel metal-free strategy for a rapid and α-selctive C-alkynylation of glycals was developed. The reaction utilizes TMSOTf as a promoter to generate in situ trimethylsilylacetylene for C-alkynylation. Thanks to this methodology, we can access C-glycosides in a single step from a variety of acetylenes , i.e., arylacetylenes and most importantly aliphatic alkynes.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR); Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu -Tawi, 180001, India.
authors.forename: Shekaraiah
authors.initials: S
authors.lastname: Devari
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR); Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu -Tawi, 180001, India.
authors.forename: Manjeet
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR); Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu -Tawi, 180001, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Deshidi
authors.affiliation: Department of Chemistry, University of Kashmir, 190006, India.
authors.forename: Masood
authors.initials: M
authors.lastname: Rizvi
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR); Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu -Tawi, 180001, India.
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
keywords: C-alkynylation; TMSOTf; glycal; metal free; α-selective