title: Post-transplant lymphoproliferative disorder after kidney transplantation: time to adopt monitoring of Epstein-Barr virus?
abstract: Although post-transplant lymphoproliferative disorder is a classical complication encountered after kidney transplantation, its diagnosis can still be challenging and its outcome life-threatening. Most cases are related to Epstein-Barr virus (EBV) infection and occur mainly in the first year post-transplant, favoured by the seronegative EBV status of the recipient transplanted with a kidney from a seropositive donor, and strong immunosuppression. We report the case of a young kidney-pancreas transplant recipient who developed post-transplant lymphoproliferative disorder (PTLD) early after transplantation, with a rapid fatal issue. We review the pathogenesis, clinical presentation, and management of PTLD with a focus on prevention.
authors.forename: P
authors.initials: P
authors.lastname: Biller
authors.forename: L
authors.initials: L
authors.lastname: Michaux
authors.forename: L De
authors.initials: LD
authors.lastname: Pauw
authors.forename: A
authors.initials: A
authors.lastname: Camboni
authors.forename: M
authors.initials: M
authors.lastname: Mourad
authors.forename: N
authors.initials: N
authors.lastname: Kanaan
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents
keywords: EBV; Epstein-Barr virus,; Lymphoma,; PTLD,; Transplantation,