title: A New Variant of Connective Tissue Nevus with Elastorrhexis and Predilection for the Upper Chest.
abstract: Localized changes in cutaneous elastic tissue often manifest with flesh-colored, hypopigmented, or yellow papules, plaques, and nodules. We present five children with clinically similar cobblestone plaques composed of multiple hypopigmented, nonfollicular, pinpoint papules located unilaterally over the upper chest. All lesions first appeared at birth or during early infancy. No associated extracutaneous abnormalities have been identified. Histopathology was remarkable for many, thick elastic fibers with elastorrhexis. We believe that these cases represent a distinct and unique variant of connective tissue nevi.
authors.affiliation: Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Derek H
authors.initials: DH
authors.lastname: Chu
authors.affiliation: Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Hayley
authors.initials: H
authors.lastname: Goldbach
authors.affiliation: Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
authors.forename: Karolyn A
authors.initials: KA
authors.lastname: Wanat
authors.affiliation: Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.|Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Adam I
authors.initials: AI
authors.lastname: Rubin
authors.affiliation: Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Albert C
authors.initials: AC
authors.lastname: Yan
authors.affiliation: Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: James R
authors.initials: JR
authors.lastname: Treat
mesh_terms: D001706:Biopsy; D002648:Child; D003240:Connective Tissue Diseases / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009506:Nevus / Q000175:diagnosis* / Q000473:pathology; D013909:Thorax