title: Epithelial cell polarity determinant CRB3 in cancer development.
abstract: Cell polarity, which is defined as asymmetry in cell shape, organelle distribution and cell function, is essential in numerous biological processes, including cell growth, cell migration and invasion, molecular transport, and cell fate. Epithelial cell polarity is mainly regulated by three conserved polarity protein complexes, the Crumbs (CRB) complex, partitioning defective (PAR) complex and Scribble (SCRIB) complex. Research evidence has indicated that dysregulation of cell polarity proteins may play an important role in cancer development. Crumbs homolog 3 (CRB3), a member of the CRB complex, may act as a cancer suppressor in mouse kidney epithelium and mouse mammary epithelium. In this review, we focus on the current data available on the roles of CRB3 in cancer development.
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University.
authors.forename: Pingping
authors.initials: P
authors.lastname: Li
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Mao
authors.affiliation: 2. Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ren
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University.
authors.forename: Peijun
authors.initials: P
authors.lastname: Liu
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D007668:Kidney / Q000166:cytology; D008321:Mammary Glands, Animal / Q000166:cytology; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C530695:Crb3 protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D046912:Multiprotein Complexes
keywords: CRB3; EMT; apical-basal polarity; cancer