title: Determining the Cost-Savings Threshold for HIV Adherence Intervention Studies for Persons with Serious Mental Illness and HIV.
abstract: Persons with serious mental illnesses are at increased risk for contracting and transmitting HIV and often have poor adherence to medication regimens. Determining the economic feasibility of different HIV adherence interventions among individuals with HIV and serious mental illness is important for program planners who must make resource allocation decisions. The goal of this study was to provide a methodology to estimate potential cost savings from an HIV medication adherence intervention program for a new study population, using data from prior published studies. The novelty of this approach is the way CD4 count data was used as a biological marker to estimate costs averted by greater adherence to anti-retroviral treatment. Our approach is meant to be used in other adherence intervention studies requiring cost modeling.
authors.affiliation: Department of Psychiatry, Center for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market Street, #3103, Philadelphia, PA, 19104, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Wu
authors.affiliation: Department of Psychiatry, Center for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market Street, #3103, Philadelphia, PA, 19104, USA.|Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.|School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Aileen
authors.initials: A
authors.lastname: Rothbard
authors.affiliation: Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Holtgrave
authors.affiliation: Department of Psychiatry, Center for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market Street, #3103, Philadelphia, PA, 19104, USA. Mblank2@upenn.edu.|Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Mblank2@upenn.edu.|Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, USA. Mblank2@upenn.edu.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Blank
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D017046:Cost Savings; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000191:economics; D005102:Health Expenditures; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D001523:Mental Disorders / Q000150:complications* / Q000191:economics; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents
keywords: HIV/AIDS; Health expenditures; Serious mental illness