title: The role of the potassium channel gene KCNK2 in major depressive disorder.
abstract: Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Congiu
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address: alessandra.minelli@unibs.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Minelli
authors.affiliation: Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.
authors.forename: Cristian
authors.initials: C
authors.lastname: Bonvicini
authors.affiliation: Psychiatric Hospital "Villa Santa Chiara", Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bortolomasi
authors.affiliation: Department of Philosophy, Education, Psychology, University of Verona, Verona, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sartori
authors.affiliation: Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Maj
authors.affiliation: Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.
authors.forename: Catia
authors.initials: C
authors.lastname: Scassellati
authors.affiliation: S.C.D.U. Psychiatric Service, AOU San Luigi Gonzaga, University of Turin, Orbassano (TO), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maina
authors.affiliation: Psychiatric Hospital "Villa Santa Chiara", Verona, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Trabucchi
authors.affiliation: Psychiatric Hospital "Villa Santa Chiara", Verona, Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Segala
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Gennarelli
mesh_terms: D000328:Adult; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D061218:Depressive Disorder, Treatment-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D024683:Potassium Channels, Tandem Pore Domain / Q000235:genetics*
chemical_list: D000928:Antidepressive Agents; D024683:Potassium Channels, Tandem Pore Domain; C103742:potassium channel protein TREK-1
keywords: KCNK2; Major depressive disorder; Psychotic symptoms