title: Biomimetic glycopolymers tethered gold nanoparticles: preparation, self-assembly and lectin recognition properties.
abstract: Biomimetic glycopolymers poly(gluconamidoethylmethacrylate)-b-poly(ɛ-caprolactone)-b-poly(gluconamidoethylmethacrylate) with degradable disulfide groups in the backbone (PGAMA-PCL-SS-PCL-PGAMA) were synthesized by the combination of ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The internal disulfide bonds were cleaved by reduction with dl-dithiothreitol to yield the corresponding thiol terminated glycopolymers. The thiol terminated glycopolymers were effectively anchored on the surface of gold nanoparticles to prepare the biomimetic glycopolymers modified gold nanoparticles (Gly@Au NPs). Moreover, the properties of the Gly@Au NPs in aqueous solution were investigated. Transmission electron microscopy (TEM) analysis revealed that the self-assembly morphology of the Gly@Au NPs can be fine-tuned, from irregular clusters to spherical aggregates, by changing the weight fraction of the hydrophobic PCL block. Furthermore, the Gly@Au NPs had specific recognition with Concanavalin A (Con A).
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Pei
authors.affiliation: Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Jilin Province 130021, PR China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Food Science Department, Cook College, Rutgers University, New Brunswick, NJ 08901-8520,United States.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Clinical Laboratory Center, Air Force General Hospital, No. 30 Fucheng Road, Haidian District, Beijing 100142, PR China.
authors.forename: Qu
authors.initials: Q
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: fli1216@ciac.ac.cn.
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: tfshi@ciac.ac.cn.
authors.forename: Tongfei
authors.initials: T
authors.lastname: Shi
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D037102:Lectins / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D037102:Lectins; D011108:Polymers; D006046:Gold
keywords: Degradable; Glycopolymer; Gold nanoparticle; Lectin recognition; Self-assembly