title: Nanostructured thick 3D nanofibrous scaffold can induce bone.
abstract: Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(ε-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France.
authors.forename: Sandy
authors.initials: S
authors.lastname: Eap
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
authors.forename: David
authors.initials: D
authors.lastname: Morand
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
authors.forename: François
authors.initials: F
authors.lastname: Clauss
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Huck
authors.affiliation: Hôpital Central, Service de Chirurgie Orthopédique and CNRS UMR 7561, Nancy, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Stoltz
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Hôpital Civil, service de Chirurgie Maxillo-Faciale, Strasbourg, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lutz
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France.
authors.forename: Jacques-Eric
authors.initials: JE
authors.lastname: Gottenberg
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Benkirane-Jessel
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Keller
authors.affiliation: French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Fioretti
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000138:chemical synthesis*; D002478:Cells, Cultured; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D010012:Osteogenesis / Q000502:physiology; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry; D012887:Skull Fractures / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C016240:polycaprolactone
keywords: 3D scaffold; Bone induction; electrospinning; polycaprolactone; tissue engineering