title: Quality control mechanisms in cellular and systemic DNA damage responses.
abstract: The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses (DDR) alone. Quality control pathways play an important role in DNA repair and cellular DDR pathways. Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing. We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability.
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: ermolaem@uni-koeln.de.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Ermolaeva
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Dakhovnik
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
authors.forename: Björn
authors.initials: B
authors.lastname: Schumacher
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics* / Q000502:physiology*; D015894:Genome, Human / Q000235:genetics / Q000502:physiology; D042822:Genomic Instability; D006801:Humans; D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology; D011786:Quality Control
keywords: Ageing; DNA damage; DNA repair; Genome stability; Progeroid syndromes; Ubiquitin proteasome system