title: Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion.
abstract: Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
authors.forename: Mrinali Patel
authors.initials: MP
authors.lastname: Gupta
authors.forename: Peter
authors.initials: P
authors.lastname: Coombs
authors.forename: Susan E
authors.initials: SE
authors.lastname: Prockop
authors.forename: Aisha A
authors.initials: AA
authors.lastname: Hasan
authors.forename: Ekatarina
authors.initials: E
authors.lastname: Doubrovina
authors.forename: Richard J
authors.initials: RJ
authors.lastname: O'Reilly
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Cohen
authors.forename: Susanna S
authors.initials: SS
authors.lastname: Park
authors.forename: Szilárd
authors.initials: S
authors.lastname: Kiss
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification; D017726:Cytomegalovirus Retinitis / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D016219:Immunotherapy, Adoptive; D007262:Infusions, Intravenous; D008297:Male; D010750:Phosphoproteins / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load; D014763:Viral Matrix Proteins / Q000276:immunology*; D014766:Viremia / Q000628:therapy
chemical_list: D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa