title: Emerging potential of citrus flavanones as an antioxidant in diabetes and its complications.
abstract: A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, antihyperglycemic, anti-apoptotic etc. Naringin and hesperidin along with their respective aglycones, naringenin and hesperetin have been shown to attenuate diabetes and its related complications. This review discusses the role of flavanones as a possible emerging treatment for diabetes and its complications along with the possible mechanistic explanations.
authors.forename: Malvika
authors.initials: M
authors.lastname: Sharma
authors.forename: Nadeem
authors.initials: N
authors.lastname: Akhtar
authors.forename: Kumar
authors.initials: K
authors.lastname: Sambhav
authors.forename: Ganesh
authors.initials: G
authors.lastname: Shete
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Bansal
authors.affiliation: Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab, India. sssharma@niper.ac.in.
authors.forename: Shyam S
authors.initials: SS
authors.lastname: Sharma
mesh_terms: D000975:Antioxidants / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D002957:Citrus / Q000737:chemistry*; D048909:Diabetes Complications / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D044950:Flavanones / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D044950:Flavanones