title: Lipid-dependent regulation of the unfolded protein response.
abstract: Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal transduction pathways that are activated by an imbalance between unfolded proteins and chaperones (so called ER stress). Collectively referred to as the unfolded protein response (UPR) this homeostatic response is initiated by three known ER stress transducers: IRE1, PERK and ATF6. These ER-localised transmembrane (TM) proteins posses lumenal stress sensing domains and cytosolic effector domains that collectively activate a gene expression programme regulating the production of proteins involved in the processing and maturation of secreted proteins that enter the ER. However, beyond limiting unfolded protein stress in the ER the UPR has important connections to lipid metabolism that are the subject of this review.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust MRC Institute of Metabolic Science, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom; Université de Toulouse, INP, ENVT, INRA, UMR 1225, IHAP, Toulouse, France. Electronic address: r.volmer@envt.fr.
authors.forename: Romain
authors.initials: R
authors.lastname: Volmer
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust MRC Institute of Metabolic Science, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom. Electronic address: dr360@medschl.cam.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Ron
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D056890:Eukaryota / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D018832:Molecular Chaperones / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D017510:Protein Folding; D015398:Signal Transduction; D056811:Unfolded Protein Response
chemical_list: D018832:Molecular Chaperones