title: The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function.
abstract: The evolutionarily conserved Bucentaur (BCNT) protein superfamily was identified about two decades ago in bovines, but its biological role has long remained largely unknown. Sparse studies in the literature suggest that BCNT proteins perform important functions during development. Only recently, a functional analysis of the Drosophila BCNT ortholog, called YETI, has provided evidence that it is essential for proper fly development and plays roles in chromatin organization. Here, we introduce the BCNT proteins and comprehensively review data that contribute to clarify their function and mechanistic clues on how they may control development in multicellular organisms.
authors.affiliation: Dipartimento di Biologia e Biotecnologie "Charles Darwin", Sapienza Università di Roma, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Messina
authors.forename: Emanuele
authors.initials: E
authors.lastname: Celauro
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Atterrato
authors.forename: Ennio
authors.initials: E
authors.lastname: Giordano
authors.forename: Shintaro
authors.initials: S
authors.lastname: Iwashita
authors.forename: Patrizio
authors.initials: P
authors.lastname: Dimitri
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002645:Chickens / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009687:Nuclear Proteins; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D015027:Zebrafish / Q000235:genetics
chemical_list: C104422:CFDP1 protein, human; D002352:Carrier Proteins; C121022:Cfdp1 protein, mouse; D002843:Chromatin; D029721:Drosophila Proteins; D016326:Extracellular Matrix Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; C492567:Yeti protein, Drosophila