title: A leave-one-out cross-validation SAS macro for the identification of markers associated with survival.
abstract: A proper internal validation is necessary for the development of a reliable and reproducible prognostic model for external validation. Variable selection is an important step for building prognostic models. However, not many existing approaches couple the ability to specify the number of covariates in the model with a cross-validation algorithm. We describe a user-friendly SAS macro that implements a score selection method and a leave-one-out cross-validation approach. We discuss the method and applications behind this algorithm, as well as details of the SAS macro.
authors.affiliation: Department of Biostatistics and Bioinformatics & Duke Cancer Biostatistics, Duke University School of Medicine, Durham, NC, United States.
authors.forename: Christel
authors.initials: C
authors.lastname: Rushing
authors.affiliation: Department of Biostatistics and Bioinformatics & Duke Cancer Biostatistics, Duke University School of Medicine, Durham, NC, United States.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Bulusu
authors.affiliation: Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
authors.forename: Herbert I
authors.initials: HI
authors.lastname: Hurwitz
authors.affiliation: Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Nixon
authors.affiliation: Department of Biostatistics and Bioinformatics & Duke Cancer Biostatistics, Duke University School of Medicine, Durham, NC, United States; School of Public Health, Li Ka Shing Faculty of Medicine, Pok Fu Lam, Hong Kong SAR, China. Electronic address: pathwayrf@gmail.com.
authors.forename: Herbert
authors.initials: H
authors.lastname: Pang
mesh_terms: D000465:Algorithms; D015415:Biomarkers; D002986:Clinical Trials as Topic; D019295:Computational Biology; D003198:Computer Simulation; D006801:Humans; D011379:Prognosis; D015203:Reproducibility of Results; D016019:Survival Analysis
chemical_list: D015415:Biomarkers
keywords: Clinical trials; Cross-validation; Prognostic markers; SAS macro; Score selection; Survival analysis