title: Osteopontin is a novel prognostic biomarker in early-stage non-small cell lung cancer after surgical resection.
abstract: OBJECTIVE
  Osteopontin (OPN), an extracellular matrix-secreted phosphorylated glycoprotein, has been reported overexpressed in many solid tumors. As an important part of lung cancer, the high recurrence of non-small cell lung cancer (NSCLC) also attracted great attention of scientists.
  
  
  METHODS
  In this study, we investigated the expression of OPN and the relationship with prognosis of NSCLC patients. We measured the expression of OPN among 163 NSCLC samples by immunohistochemical method and compared the expression of these 28 matched cDNA between tumor and peritumoral tissue by real-time polymerase chain reaction.
  
  
  RESULTS
  We demonstrated that the percentages of positive OPN expression is 66.8 % and OPN expression in tumor site was much higher than the tissue adjacent to carcinoma (p = 0.0046). By further analysis, we found that OPN expression was significantly correlated with poor prognosis of NSCLC. Moreover, for early-stage patients, OS and DFS rates of OPN (-) group were significantly higher than OPN (+) group. For advanced-stage patients, OPN expression was only associated with OS rates.
  
  
  CONCLUSIONS
  These results suggest that OPN is commonly expressed in NSCLC and may guide the evaluation of prognosis with NSCLC, especially for early-stage patients.
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
authors.forename: Ci Hui
authors.initials: CH
authors.lastname: Yan
authors.forename: Mengguo
authors.initials: M
authors.lastname: Lv
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Song
authors.forename: Fan
authors.initials: F
authors.lastname: Yan
authors.forename: Shui
authors.initials: S
authors.lastname: Cao
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D053495:Osteopontin / Q000378:metabolism*; D011013:Pneumonectomy; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D053495:Osteopontin