title: Homing properties of mesenchymal stromal cells.
abstract: A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little is known however about the homing mechanisms of these cells to sites of injury and inflammation. This is important if one is to enhance this process to improve the therapeutic outcome. We have addressed this issue by highlighting what is known and through an analogy with leukocyte homing, and have identified possible areas of future research.
authors.affiliation: University of Pretoria, Department of Immunology , PO Box 2034, Pretoria 0001 , South Africa.
authors.forename: Karlien
authors.initials: K
authors.lastname: Kallmeyer
authors.forename: Michael S
authors.initials: MS
authors.lastname: Pepper
mesh_terms: D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000276:immunology*
keywords: cell migration; cell-based therapy; chemokine; homing; mesenchymal stromal cell; tissue injury