title: Selective extraction and concentration of mebendazole in seawater samples using molecularly imprinted polymer as sorbent.
abstract: A high selective pre-treatment method for the extraction and analysis of mebendazole in environmental water samples was developed based on molecularly imprinted solid-phase extraction (MISPE). The mebendazole imprinted polymers were synthesized in acetonitrile using methacrylic acid and ethylene glycol dimethacrylate as functional monomer and cross-linker respectively. The imprinted materials showed high adsorption ability for mebendazole and were applied as special solid-phase extraction sorbents for selective separation of mebendazole. An off-line MISPE procedure was developed for the purification and enrichment of mebendazole from natural seawater samples prior to high-performance liquid chromatography analysis. The recoveries of spiked seawater on the MISPE cartridges were from 83.0% to 90.6%, and the values of the relative standard deviation were in the range of 2.78-4.13% (n=3). The satisfied results showed that this pre-treatment methodology for extracting mebendazole in seawater was simple and effective.
authors.affiliation: Marine College, Shandong University, Weihai 264209, China.
authors.forename: Ziru
authors.initials: Z
authors.lastname: Lian
authors.affiliation: Marine College, Shandong University, Weihai 264209, China. Electronic address: liang@ouc.edu.cn.
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China. Electronic address: jtwang@ouc.edu.cn.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D000969:Antinematodal Agents / Q000032:analysis / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D052918:Environmental Restoration and Remediation / Q000379:methods*; D008463:Mebendazole / Q000032:analysis / Q000302:isolation & purification*; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012623:Seawater / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000302:isolation & purification*
chemical_list: D000969:Antinematodal Agents; D008689:Methacrylates; D011108:Polymers; D014874:Water Pollutants, Chemical; C008384:methacrylic acid; C004919:ethylene dimethacrylate; D008463:Mebendazole
keywords: Adsorption; Mebendazole; Molecularly imprinted polymer; Natural seawater; Solid-phase extraction