title: What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?
abstract: Besides its pandemic potential, seasonal influenza infection is associated with an estimated 250,000 to 500,000 deaths worldwide every year. Part of this virulence of influenza virus can be attributed to its ability to evade the host innate immune response. Here, we discuss the possibility of using a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like protein, to combat influenza infections.
authors.affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Alcorn
authors.forename: Saumendra N
authors.initials: SN
authors.lastname: Sarkar
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000379:methods*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007251:Influenza, Human / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000628:therapy* / Q000821:virology; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D012367:RNA, Viral / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; C115020:OASL protein, human; D015088:2',5'-Oligoadenylate Synthetase
keywords: OASL; RIG-I; influenza; interferon