title: Palladium(II)-catalyzed intramolecular tandem aminoalkylation via divergent C(sp3)-H functionalization.
abstract: We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp(3))-H functionalization, affording three- and five-membered-ring fused indolines in good yields under two optimized conditions, respectively. The mechanism studies have indicated that the benzylic C-H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C-H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp(3))-H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles.
authors.affiliation: Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Qiangshuai
authors.initials: Q
authors.lastname: Gu
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Yang