title: A fast and activatable cross-linking strategy for hydrogel formation.
abstract: Strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) is a fast and activatable cross-linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ-formed hydrogels can be functionalized in one-pot with an azido-containing moiety using SPAAC cross-linking.
authors.affiliation: Heyendaalseweg 135, 6525, AJ, Nijmegen, The Netherlands.
authors.forename: Anika M
authors.initials: AM
authors.lastname: Jonker
authors.forename: Annika
authors.initials: A
authors.lastname: Borrmann
authors.forename: Ernst R H
authors.initials: ER
authors.lastname: van Eck
authors.forename: Floris L
authors.initials: FL
authors.lastname: van Delft
authors.forename: Dennis W P M
authors.initials: DW
authors.lastname: Löwik
authors.forename: Jan C M
authors.initials: JC
authors.lastname: van Hest
keywords: activatable; cross-linking; hydrogel; oxidation