title: The RIT2 and STX1B polymorphisms are associated with Parkinson's disease.
abstract: BACKGROUND
  GWAS meta-analysis identified RIT2 rs12456492 and STX1B rs4889603 as PD susceptible loci. While proteins encoded by the genes, in particular RIT2, may involve in PD pathogenesis, the association of these two variants with PD remains to be further clarified.
  
  
  METHODS
  We enrolled a Chinese cohort comprising 537 PD patients and 517 controls, determined the genotypes of rs12456492 and rs4889603, and analyzed these variants in relation to PD.
  
  
  RESULTS
  Both rs12456492 and rs4889603 were associated with PD susceptibility (P = 0.012 and 0.03, respectively). The G allele of rs12456492 and the A allele of rs4889603 served as risk alleles toward PD. Statistical differences in genotype distribution between the patients and controls were observed both in rs12456492 (marginal, P = 0.042 for GG vs. AG vs. AA) and in rs4889603 (P = 0.021 for AA + AG vs.
  Our data suggest that the RIT2 and STX1B polymorphisms are associated with PD etiology. The role of RIT2 in PD pathogenesis warrants further mechanistical investigation.
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Gong
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Yang-Lie
authors.initials: YL
authors.lastname: Ye
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Jin-Min
authors.initials: JM
authors.lastname: Ye
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Lin
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Zhuang
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: zhangxiong98@gmail.com.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics & Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: jianhong.zhu@gmail.com.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D000368:Aged; D044466:Asian People; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050827:Syntaxin 1 / Q000235:genetics*
chemical_list: D050827:Syntaxin 1; D020559:Monomeric GTP-Binding Proteins; C583559:RiT2 protein, human
keywords: Association; Parkinson's disease; Polymorphism; RIT2; STX1B