title: Arterial stiffness is increased in young women with endometriosis.
abstract: Endometriosis is a chronic gynaecological disorder that is accompanied by inflammation and oxidative stress. Atherosclerosis has a long subclinical progression in arteries of children and young adults decades before overt clinical manifestations of the disease. In this study, we determined arterial stiffness by measuring brachial-ankle pulse wave velocity (baPWV) in women with endometriosis to assess the presence of subclinical atherosclerosis. We also measured markers of inflammation and oxidative stress in women with endometriosis. baPWV in women with endometriosis aged over 30 years was significantly higher than that in women without endometriosis aged over 30 years (p < 0.05), but not in women aged less than 30. Serum high-sensitivity C-reactive protein level in women with endometriosis was significantly higher than that in controls (p < 0.05). Young women with endometriosis show significantly increased arterial stiffness, suggesting that women with endometriosis need to be cautious of the future onset of atherosclerosis.
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tani
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: b Department of Obstetrics and Gynecology , Tokushima Prefectural Central Hospital , Tokushima , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maegawa
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kunimi
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Keyama
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.affiliation: c Department of Preventive Medicine , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Uemura
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kuwahara
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuzaki
authors.affiliation: d Department of Reproductive Technology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yasui
authors.affiliation: e Department of Obstetrics and Gynecology , Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers , Ehime , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kamada
authors.affiliation: f Department of Cardiovascular Medicine , Institute of Health Bioscience, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Soeki
authors.affiliation: f Department of Cardiovascular Medicine , Institute of Health Bioscience, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.affiliation: a Department of Obstetrics and Gynecology , Institute of Health Biosciences, The University of Tokushima Graduate School , Tokushima , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D018394:CA-125 Antigen / Q000097:blood; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D018394:CA-125 Antigen; D002097:C-Reactive Protein
keywords: arterial stiffness; endometriosis; hs CRP; subclinical inflammation; young women