title: [Formation of Enterobacter cloacae resistance to disinfectants under the effect of bactericidal concentrations of quaternry ammonium compounds in the experiment].
abstract: OBJECTIVE
  Study the possibility of formation of induced resistance of purulent-septic infection (PSI) causative agents against disinfectants (DI) in bactericidal concentrations.
  
  
  METHODS
  Daily exposure to bactericidal concentrations of preparations from the group of quaternary ammonium compounds (QAC) on Enterobacter cloacae strain that has incomplete sensitivity to the same disinfectants on the same test objects was carried out in experiments on test objects from wood and plastic. Exposure was carried out until the moment of transition from incomplete sensitivity to resistance.
  
  
  RESULTS
  E. cloacae strain that initially had incomplete sensitivity to various disinfectants of the QAC group in antibacterial concentrations according to manuals acquires resistance on test objects from wood and plastic after 2 - 12 exposures to the preparations.
  
  
  CONCLUSIONS
  The data obtained give evidence that the resistance of PSI causative agents to disinfectants can take place not only under the influence of low concentrations of the preparations but also during use of disinfectants at bactericidal concentrations.
authors.forename: V I
authors.initials: VI
authors.lastname: Sergevnin
authors.forename: T V
authors.initials: TV
authors.lastname: Kliukina
authors.forename: E O
authors.initials: EO
authors.lastname: Volkova
authors.forename: N I
authors.initials: NI
authors.lastname: Reshetnikova
authors.forename: L G
authors.initials: LG
authors.lastname: Kudriavtseva
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004202:Disinfectants / Q000008:administration & dosage; D024881:Drug Resistance, Bacterial / Q000187:drug effects* / Q000235:genetics; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D004756:Enterobacteriaceae Infections / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D005516:Food Microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D004202:Disinfectants; D000644:Quaternary Ammonium Compounds