title: The association between platelet/lymphocyte ratio and coronary artery disease severity.
abstract: OBJECTIVE
  In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD).
  
  
  METHODS
  Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score, which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score.
  
  
  RESULTS
  The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups (p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together with WBC, age, and low HDL level, in the multivariate analysis.
  
  
  CONCLUSIONS
  Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting severe atherosclerosis.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Dicle University; Diyarbakır-Turkey. yukselmurat@yahoo.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Yüksel
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yıldız
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oylumlu
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Akyüz
authors.forename: Mesut
authors.initials: M
authors.lastname: Aydın
authors.forename: Hasan
authors.initials: H
authors.lastname: Kaya
authors.forename: Halit
authors.initials: H
authors.lastname: Acet
authors.forename: Nihat
authors.initials: N
authors.lastname: Polat
authors.forename: Mehmet Zihni
authors.initials: MZ
authors.lastname: Bilik
authors.forename: Sait
authors.initials: S
authors.lastname: Alan
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index