title: A photoCORM nanocarrier for CO release using NIR light.
abstract: A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for CO delivery to biological targets.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. ford@chem.ucsb.edu.
authors.forename: Agustin E
authors.initials: AE
authors.lastname: Pierri
authors.forename: Po-Ju
authors.initials: PJ
authors.lastname: Huang
authors.forename: John V
authors.initials: JV
authors.lastname: Garcia
authors.forename: James G
authors.initials: JG
authors.lastname: Stanfill
authors.forename: Megan
authors.initials: M
authors.lastname: Chui
authors.forename: Guang
authors.initials: G
authors.lastname: Wu
authors.forename: Nanfeng
authors.initials: N
authors.lastname: Zheng
authors.forename: Peter C
authors.initials: PC
authors.lastname: Ford
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D007259:Infrared Rays; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D014867:Water; D002248:Carbon Monoxide