title: Necrotizing and sarcoidal granulomas in the skin and synovial membrane, associated with common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia, T-cell abnormalities and recurrent bacterial infections. Patients with CVID can present granulomatous lesions on both the skin and other organs. When these lesions are the first sign of the disease, the diagnosis can be very challenging. We report the case of a patient with undiagnosed CVID, who presented with necrotizing and sarcoidal granulomas on the skin and synovial membrane as the first appearance of immunodeficiency.
authors.affiliation: Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Plana Pla
authors.affiliation: Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bassas-Vila
authors.affiliation: Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Roure
authors.affiliation: Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ferrándiz
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000175:diagnosis*; D005260:Female; D006099:Granuloma / Q000175:diagnosis*; D006801:Humans; D012507:Sarcoidosis / Q000175:diagnosis*; D012871:Skin Diseases / Q000175:diagnosis*; D013583:Synovial Membrane