title: Dendritic cell metabolism.
abstract: The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes that control DC immune functions, but also affect metabolic pathways, thereby integrating the cellular requirements of the activation process. In this Review, we focus on this relatively new area of research and attempt to describe an integrated view of DC immunometabolism.
authors.affiliation: Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Pearce
authors.affiliation: Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
authors.forename: Bart
authors.initials: B
authors.lastname: Everts
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D042541:Intracellular Space / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D015398:Signal Transduction