title: Ascending in utero herpes simplex virus infection in an initially healthy-appearing premature infant.
abstract: The usual route of acquisition for intrauterine herpes simplex virus (HSV) infection is transplacental. We evaluated a premature infant with in utero acquisition of HSV resulting from ascending infection. Histopathologic evidence of chronic chorioamnionitis and positive staining with immunohistochemistry for HSV in the placenta and umbilical cord established the diagnosis. The clinical presentation was also of interest in that the infant was initially healthy appearing.
authors.affiliation: 1 Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
authors.forename: Morven S
authors.initials: MS
authors.lastname: Edwards
authors.forename: Edwina J
authors.initials: EJ
authors.lastname: Popek
authors.forename: Brittany
authors.initials: B
authors.lastname: Wise
authors.forename: Lindsay
authors.initials: L
authors.lastname: Hatzenbuehler
authors.forename: Athis R
authors.initials: AR
authors.lastname: Arunachalam
authors.forename: Amy B
authors.initials: AB
authors.lastname: Hair
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D002821:Chorioamnionitis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D005260:Female; D005865:Gestational Age; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission* / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D010920:Placenta / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D018139:Simplexvirus / Q000276:immunology / Q000472:pathogenicity*; D014470:Umbilical Cord / Q000821:virology; D055815:Young Adult
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D000212:Acyclovir
keywords: Ascending infection; chorioamnionitis; congenital infection; herpes simplex virus; in utero infection; intrauterine