title: Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives.
abstract: The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1,2,4-triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2,3,4) in an alkaline solution, is reported. Also, the S-alkylation of triazole derivatives 5-7a-c is described. The structure of the synthesized compounds resulted from the IR, (1)H and -(13)C NMR spectroscopy and elemental analysis data. The antibacterial studies to all of the synthesized compounds against B. cereus, E. coli, P. aeroginosa, S. aureus and E. faecalis as MIC values are reported. Some of these compounds such as 7a, 4a and 3a exhibited a good to significant antibacterial activity.
authors.affiliation: Department of Chemistry, Payame Noor University, Tehran , Iran .
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kalhor
authors.affiliation: Department of Chemistry, Payame Noor University, Tehran , Iran .
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Shabani
authors.affiliation: Laboratory of Microbiology and Immunology of Infectious Diseases, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Nikokar
authors.affiliation: Laboratory of Microbiology and Immunology of Infectious Diseases, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Seyedeh
authors.initials: S
authors.lastname: Reyhaneh Banisaeed
keywords: 1; 2; 4-Triazole-3-thiol; Antibacterial activity; Microorganisms; S-alkylation; Thiosemicarbazide