title: HGF and c-Met in pathogenesis of endometrial carcinoma.
abstract: Hepatocyte growth factor (HGF) regulates cell growth, motility, and morphogenesis of various types of cells via its receptor c-Met. In the growth of endometrium, HGF/c-Met signaling promotes the proliferation of both endometrial epithelial cells and stromal cells. In the onset and development of several cancers, HGF/c-Met signaling drives carcinogenesis and cancer invasion and metastasis. In endometrial carcinoma (EC), accounting for a majority of cancer-related morbidity and mortality among women, the increased expression of HGF and c-Met signaling is associated with a poor prognosis of EC patients. Thus, we will discuss the role of HGF and c-Met in the EC pathogenesis in this review.
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xin
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Hua
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
mesh_terms: D016889:Endometrial Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004717:Endometrium / Q000166:cytology / Q000378:metabolism; D005260:Female; D017228:Hepatocyte Growth Factor / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism; D000076202:c-Mer Tyrosine Kinase
chemical_list: D011518:Proto-Oncogene Proteins; D017228:Hepatocyte Growth Factor; C097072:MERTK protein, human; D020794:Receptor Protein-Tyrosine Kinases; D000076202:c-Mer Tyrosine Kinase