title: Tolerability of induction chemotherapy dosing practices in acute myeloid leukemia patients.
abstract: For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2m(2)) who received capped doses (n=12) to those who received uncapped doses (n=24), and to patients with BSA≤2m(2) (n=42). There were no statistically significant differences among groups (BSA≤2m(2), BSA>2m(2) capped, and BSA>2m(2) uncapped) in the incidences of febrile neutropenia (85.7, 66.7, and 75.0%, respectively, p=0.29), bacteremia (19.0, 8.3, and 16.7%, respectively, p=0.68), mucositis (42.8, 50.0, and 41.7%, respectively, p=0.88) or nausea/vomiting (47.6, 33.3, and 37.5, respectively, p=0.57). Results suggest delivery of unadjusted chemotherapy based on actual body weight is likely safe in hematological malignancies.
authors.affiliation: St. Vincent Indianapolis Hospital, Department of Pharmacy, 2001 W. 86th Street, Indianapolis, IN, USA.
authors.forename: Kaylene M
authors.initials: KM
authors.lastname: Peric
authors.affiliation: St. Vincent Indianapolis Hospital, Department of Pharmacy, 2001 W. 86th Street, Indianapolis, IN, USA; College of Pharmacy and Health Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN, USA. Electronic address: djreeves@stvincent.org.
authors.forename: David J
authors.initials: DJ
authors.lastname: Reeves
mesh_terms: D016470:Bacteremia / Q000139:chemically induced / Q000453:epidemiology; D001830:Body Surface Area; D064147:Febrile Neutropenia / Q000139:chemically induced / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000139:chemically induced / Q000453:epidemiology; D009325:Nausea / Q000139:chemically induced / Q000453:epidemiology; D012189:Retrospective Studies; D014839:Vomiting / Q000139:chemically induced / Q000453:epidemiology
keywords: Acute myeloid leukemia; Dosing; Obesity