title: Effect of external magnetic field on IV 99mTc-labeled aminosilane-coated iron oxide nanoparticles: demonstration in a rat model: special report.
abstract: Among the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.
authors.affiliation: From the Departments of *Radiological, Oncological, and Pathological Sciences, †Chemistry, ‡Gynecology, Obstetrics, and Urology, Laboratory of Biochemistry of Sexual Hormones, and §Anatomy, Histology, Forensic Medicine, and Orthopedics, Sapienza University of Rome; ∥Centre for Life Nano, Istituto Italiano di Tecnologia; ¶Department of Basic and Applied Sciences for Engineering, and **Department of Biology and Biotechnology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome; ††Department of Nuclear Medicine, PET Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy; and ‡‡Department of Radiology, University of Southern California, Los Angeles, CA.
authors.forename: Mauro
authors.initials: M
authors.lastname: Liberatore
authors.forename: Mario
authors.initials: M
authors.lastname: Barteri
authors.forename: Valentina
authors.initials: V
authors.lastname: Megna
authors.forename: Piera
authors.initials: P
authors.lastname: D'Elia
authors.forename: Stefania
authors.initials: S
authors.lastname: Rebonato
authors.forename: Augusto
authors.initials: A
authors.lastname: Latini
authors.forename: Francesca
authors.initials: F
authors.lastname: De Angelis
authors.forename: Francesca Anna
authors.initials: FA
authors.lastname: Scaramuzzo
authors.forename: Maria Egle
authors.initials: ME
authors.lastname: De Stefano
authors.forename: Noemi Antonella
authors.initials: NA
authors.lastname: Guadagno
authors.forename: Sotirios
authors.initials: S
authors.lastname: Chondrogiannis
authors.forename: Anna Margherita
authors.initials: AM
authors.lastname: Maffione
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pala
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Colletti
mesh_terms: D000818:Animals; D008099:Liver / Q000187:drug effects; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles; D008297:Male; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012821:Silanes / Q000737:chemistry; D013667:Technetium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D058185:Magnetite Nanoparticles; D019275:Radiopharmaceuticals; D012821:Silanes; D013667:Technetium