title: Maternal soluble vascular cytoplasmic adhesion molecule-1 and fibronectin levels in early- and late-onset preeclamptic pregnancies.
abstract: OBJECTIVE
  The purpose of this study was to investigate maternal plasma soluble vascular cytoplasmic adhesion molecule-1 (sVCAM-1) and fibronectin levels in the patients with early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP) and also to determine whether different mechanisms are involved in these two forms of disorders.
  
  
  METHODS
  The authors performed a case control study consisting of randomly selected 80 healthy pregnant women (group 1 = control group) and 80 preeclamptic women (group 2 = defined study group). Study group consisted of43 patients with EOP and 37 patients with LOP. sVCAM-1 and fibronectin concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and the findings were compared between the groups.
  
  
  RESULTS
  The mean levels of sVCAM-1 and fibronectin were significantly higher in the LOP group than those in the normotensive group (p = 0.043 and 0.010 respectively). Markers were significantly different between the two hypertensive groups of pregnancy. The EOP group had a higher level of sVCAM-1 and fibronectin concentration than the LOP group (p = 0.01, for both markers). There was a positive correlation both between the values of plasma fibronectin and the systolic-diastolic blood pressure measurements (r:0.43 and 0.44, respectively), and between sVCAM-1 and the systolic/diastolic blood pressure measurements (r = 0.54 and 0.64, respectively).
  
  
  CONCLUSIONS
  Increased plasma levels of fibronectin and sVCAM-1 were found in the preeclamptic patients, especially in those with early-onset preeclampsia. These markers might be related to the pathogenesis of different types of preeclampsia.
authors.affiliation: Pozanti Goverment Hospital, Adana, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Dogan
authors.forename: S Cansun
authors.initials: SC
authors.lastname: Demir
authors.forename: U Kucukgoz
authors.initials: UK
authors.lastname: Gulec
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D005353:Fibronectins; D019010:Vascular Cell Adhesion Molecule-1