title: Association between plasma homocysteine status and hypothyroidism: a meta-analysis.
abstract: OBJECTIVE
  To figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism.
  
  
  METHODS
  PubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software.
  
  
  RESULTS
  Our meta-analysis indicated that plasma Hcy concentrations elevated in OH patients without L-T4 treatment compared with healthy subjects. However, this elevation was not observed in the comparison between patients withSH without L-T4 treatment and healthy subjects. Moreover, plasma Hcy levels were found to be higher in patients with OH without L-T4 treatment than in patients with SH without L-T4 treatment. Finally, plasma Hcy concentrations decreased after L-T4 treatment in patients with SH or OH.
  
  
  CONCLUSIONS
  Plasma Hcy status is associated with the severity of hypothyroidism and L-T4 treatment is helpful for patients with hypothyroidism to reduce the plasma Hcy levels.
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Yande
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Institute of Neuroscience, Soochow University Suzhou 215123, China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
keywords: Homocysteine; levothyroxine; meta-analysis; overt hypothyroidism; subclinical hypothyroidism