title: Distributions of allele combination in single and cross loci among patients with several kinds of chronic diseases and the normal population.
abstract: Genetic research has progressed along with scientific and technological developments. However, it is difficult to identify frequency differences in a particular allele distribution at a single locus. Such differences can be identified by examining the allele combination distribution. We explored different mathematical methods for statistical analyses to assess the association between the genotype and phenotype. We investigated the frequency distributions of alleles, combinations of single-locus genes, and combinations of cross-loci genes at 15 loci using 447 blood samples of 200 normal subjects, 72 patients with chronic obstructive pulmonary resistance, 50 liver cancers, 75 stomach cancers and 50 hematencephalon and identified each population as having a unique gene distribution and that the distribution followed certain rules. The probability of illness followed different rules and had apparent specificity. Differences obtained using statistics of combinations of cross-loci genes are superior to single-locus gene statistics, and combinations of single-locus gene statistics are better than allelic statistics.
authors.affiliation: Department of Physics, Dalian Medical University, Dalian 116044, China.
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Gai
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China. Electronic address: liuhui60@sina.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
authors.forename: Jing-hui
authors.initials: JH
authors.lastname: Cui
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
authors.forename: Na
authors.initials: N
authors.lastname: Ji
authors.affiliation: Department of Physics, Dalian Medical University, Dalian 116044, China.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Ding
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Sun
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
authors.forename: Lai-shui
authors.initials: LS
authors.lastname: Yu
mesh_terms: D000483:Alleles; D002543:Cerebral Hemorrhage / Q000235:genetics; D002908:Chronic Disease; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D010641:Phenotype; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics
keywords: Chronic diseases; Genetic polymorphism; Genome