title: Optimization and evaluation of reconstruction-based compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT.
abstract: The value of Tc-99m MIBI parathyroid SPECT for localizing parathyroid hyperplasia in chronic renal failure patients remains inconclusive due to limited image quality. Advanced reconstruction methods to improve image quality have been developed but require optimization and evaluation. The goal of this study was to optimize and evaluate compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT. A phantom population and projection data that modelled clinically realistic variations found in patients were simulated. The 3D OS-EM reconstruction with compensation for attenuation, detector response and scatter in various combinations were studied. For each compensation, the number of updates for OS-EM and the cutoff frequency of a 3D Butterworth filter were optimized and evaluated using anthropomorphic model observer. With optimal parameters, the method with compensation for attenuation and detector response, with or without the addition of scatter compensation, provided the highest lesion detectability for Tc-99m MIBI parathyroid SPECT.
authors.affiliation: Department of Radiological Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand. Electronic address: tawatchai.ekj@mahidol.ac.th.
authors.forename: Tawatchai
authors.initials: T
authors.lastname: Ekjeen
authors.affiliation: Department of Radiological Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
authors.forename: Chiraporn
authors.initials: C
authors.lastname: Tocharoenchai
authors.affiliation: Department of Radiology, Siriraj Hospital, Bangkok, Thailand.
authors.forename: Pawana
authors.initials: P
authors.lastname: Pusuwan
authors.affiliation: The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: George S K
authors.initials: GS
authors.lastname: Fung
authors.affiliation: The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Ghaly
authors.affiliation: The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
authors.affiliation: The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Frey
mesh_terms: D019540:Area Under Curve; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D010279:Parathyroid Diseases / Q000000981:diagnostic imaging; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D012372:ROC Curve; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D017256:Technetium Tc 99m Sestamibi
keywords: Channelized Hotelling observer; Monte Carlo simulation; Reconstruction parameters; Reconstruction-based compensation; Tc-99m MIBI parathyroid SPECT