title: NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management.
abstract: Chronic inflammatory skin diseases such as psoriasis and eczema are a major medical challenge. Development of highly specific therapies for both conditions is opposed by the lack of translation of basic knowledge into biomarkers for clinical use. Furthermore, to distinguish psoriasis from eczema might be difficult occasionally, but specific and costly therapies would not be efficient in misdiagnosed patients. In the era of high-throughput 'omics'-technologies, comparing the molecular signature of psoriasis and eczema is a promising approach to gain insight into their complex pathogeneses and develop new diagnostic and therapeutic strategies. Investigating patients affected by both psoriasis and eczema simultaneously, we recently constructed a disease classifier consisting of only two genes (NOS2 and CCL27) that reliably predicts the correct diagnosis even in clinically unclear cases. When such easy-to-handle approaches are combined with individual therapeutic response, we might reach the ultimate goal of personalized medicine in inflammatory skin diseases in near future.
authors.affiliation: Department of Dermatology and Allergy, Technische Universität Munich, Munich, Germany.
authors.forename: Natalie
authors.initials: N
authors.lastname: Garzorz
authors.forename: Kilian
authors.initials: K
authors.lastname: Eyerich
mesh_terms: D054425:Chemokine CCL27 / Q000378:metabolism*; D004485:Eczema / Q000145:classification / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D011173:Portraits as Topic; D011565:Psoriasis / Q000145:classification / Q000175:diagnosis / Q000378:metabolism
chemical_list: C492276:CCL27 protein, human; D054425:Chemokine CCL27; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II
keywords: CCL27; NOS2; atopic dermatitis/eczema; diagnosis; diseases classifier; eczema; inflammatory skin disease; molecular signature; psoriasis