title: Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
abstract: A clinical trial of radiotherapy with modified simultaneous integrated boost (SIB) technique against huge tumors was conducted. A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial. The total dose of 77 Gy (equivalent dose in 2 Gy/fraction) and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively, and approximately 20% dose escalation was achieved with the modified SIB technique. The tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the radiotherapy. Performance status of the patient improved from 4 to 0. Radiotherapy with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance, improvement of QOL, and prolongation of survival.
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Nomiya
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Akamatsu
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Harada
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Ibuki
authors.initials: I
authors.lastname: Ota
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hagiwara
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ichikawa
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Misako
authors.initials: M
authors.lastname: Miwa
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Shouhei
authors.initials: S
authors.lastname: Kawashiro
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Motohisa
authors.initials: M
authors.lastname: Hagiwara
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Chin
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Hashizume
authors.affiliation: Takuma Nomiya, Mayumi Harada, Department of Radiation Oncology, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nemoto
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010386:Pelvic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Clinical trial; Image-guided radiotherapy; Neoplasm recurrence; Quality of life; Rectal neoplasms