title: Cardioprotective effect of resveratrol on atherogenic diet-fed rats.
abstract: Atherogenic or high fat diets were known to induce cardiovascular diseases, and several active compounds were tested to protect/prevent the risk of cardiovascular diseases. We aimed to investigate the cardio protective effect of resveratrol against atherogenic diet fed rats. Male Wistar rats were administered atherogenic diet for 30 days and further continued for 15 days with or with resveratrol in the diet. The serum lipid profile, antioxidant enzyme activity, lipid peroxidation, lipid metabolic proteins and cardiac tissue markers were examined. The histopathology of myocardium and aorta were also examined. The abnormal serum lipid profile found in atherogenic rats was reversed by the administration of resveratrol. Similarly, the enzymatic (catalase, superoxide dismutase, glutathione-peroxidase), non-enzymatic (reduced-glutathione, Vitamin C, E) antioxidants were improved by the resveratrol fed against atherogenic diet. Interestingly, resveratrol activated the lipid metabolic proteins (SIRT1, eNOS and AMPKa), suggesting its protective effect on lipid metabolism. Further analysis on tissue damage revealed that resveratrol had significantly protected the tissue damage and maintains the morphology of cardiac tissue. Altogether, our results suggest that resveratrol played a significant role in the prevention of cardiovascular system against the high fat diet. Emphasising the anti-atherogenic property of resveratrol, we propose resveratrol as a potential compound to be consumed for the healthy life-style.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Weifang Medical College Weifang City 261031, Shandong Province, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Meng
authors.affiliation: Department of Cardiology, Affiliated Hospital of Weifang Medical College Weifang City 261031, Shandong Province, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Affiliated Hospital of Weifang Medical College Weifang City 261031, Shandong Province, China.
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Du
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002374:Catalase / Q000378:metabolism; D004036:Diet, Atherogenic; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008055:Lipids; D013267:Stilbenes; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000263:Adenylate Kinase; C488368:Sirt1 protein, rat; D056564:Sirtuin 1; D000077185:Resveratrol
keywords: Antioxidants; atherosclerosis; lipid metabolism; resveratrol