title: Management of menopause in women with breast cancer.
abstract: Increasing breast cancer incidence and decreasing mortality have highlighted the importance of survivorship issues related to breast cancer. A consideration of the issues related to menopause is therefore of great importance to both women and clinicians. Menopause/menopausal symptoms, with significant negative effects on quality of life and potential long-term health impacts, may in women with breast cancer be associated with: (1) natural menopause occurring concurrently with a breast cancer diagnosis; (2) recurrence of menopausal symptoms following cessation of hormone replacement therapy; (3) treatment-induced menopause (chemotherapy, ovarian ablation/suppression) and adjuvant endocrine therapy. A variety of non-hormonal pharmacological and non-pharmacological therapies have been investigated as therapeutic options for menopausal symptoms with mixed results, and ongoing research is required. This review presents a summary of the causes, common problematic symptoms of menopause (vasomotor, genitourinary and sexual dysfunction), and longer-term consequences (cardiovascular disease and osteoporosis) related to menopause. It proposes an evidenced-based multidisciplinary approach to the management of menopause/menopausal symptoms in women with breast cancer.
authors.affiliation: a Menopause Unit, Monash Medical Centre, Monash Health and Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University , Clayton , Victoria , Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Vincent
mesh_terms: D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D005260:Female; D052776:Female Urogenital Diseases / Q000209:etiology / Q000628:therapy; D019584:Hot Flashes / Q000209:etiology / Q000628:therapy; D006801:Humans; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology / Q000628:therapy
keywords: BREAST CANCER; MANAGEMENT; MENOPAUSAL SYMPTOMS; MENOPAUSE; NON-HORMONAL