title: Pediatric de novo cerebral AVM: report of two cases and review of literature.
abstract: OBJECTIVE
  Cerebral arteriovenous malformation (AVM) is traditionally thought of as a congenital diagnosis. In recent years, there has been infrequent reports of this neurovascular condition presenting as de novo entities.
  
  
  METHODS
  The authors report two cases of pediatric patients who present with de novo cerebral AVMs. In both cases, the patients had magnetic resonance imaging (MRI) of the brain done as part of the work-up for first-onset seizures. At that point in time, the scans were unremarkable. After a latent period of approximately 6 and 9 years respectively, a repeated MRI brain scan showed evidence of de novo AVM for each patient.
  
  
  RESULTS
  Both patients did not have radiological evidence of cerebral AVM during their first presentation of seizures. However, a repeated MRI brain scan after a period of 6 and 9 years demonstrated new findings of cerebral AVM for each patient.
  
  
  CONCLUSIONS
  Currently, the disease of cerebral de novo AVM remain as an ambiguous condition that is poorly understood. With the advances in molecular diagnostics, there are possibilities of exploring biochemical profiles for better understanding of the origin of cerebral AVMs. However, in the meantime, owing to the unpredictable nature of cerebral AVMs, clinicians should have increased awareness of this unique condition. This is especially important, as definitive treatment is available to prevent devastating neurological sequelae from cerebral AVM rupture.
authors.affiliation: Faculty of Medicine, University of New South Wales, New South Wales, Australia.
authors.forename: Jared J Y
authors.initials: JJ
authors.lastname: Yeo
authors.forename: Sharon Y Y
authors.initials: SY
authors.lastname: Low
authors.forename: Wan Tew
authors.initials: WT
authors.lastname: Seow
authors.forename: David C Y
authors.initials: DC
authors.lastname: Low
mesh_terms: D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000628:therapy*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male