title: New approaches for the synthesis and cytotoxicity of thiazoles derived from cyclohexanone.
abstract: A new class of substituted thiazole derivatives 6a-c which showed promising anticancer activity was synthesized via the reaction of cyclohexanone with phenylisothiocyanate with a good yield. The latter compounds reacted with benzendiazonium chloride to form corresponding 5-phenylazothiazole derivatives 8a and 8b, respectively. Moreover, the reaction of thiazole derivatives 6a-c with each of elemental sulfur and either of malononitrile or ethyl cyanoacetate gave the thiophene derivatives 10a-e, respectively. Compounds 10a-e were subjected to a series of heterocylclization reactions to give heterocyclic derivatives. Their cytotoxicity against four human tumor cells lines was measured and showed promising anticancer activity.
authors.forename: Nermeen S
authors.initials: NS
authors.lastname: Abbas
authors.forename: Ebtsam A
authors.initials: EA
authors.lastname: Ahmed
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D017879:Isothiocyanates / Q000737:chemistry; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003512:Cyclohexanones; D017879:Isothiocyanates; D013844:Thiazoles; C005441:phenylisothiocyanate; D013455:Sulfur