title: Pedicled buccal fat pad flap as a reliable surgical strategy for the treatment of medication-related osteonecrosis of the jaw.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the coverage of the pedicled buccal fat pad flap (PBFP) and the long-term results of this treatment in patients with medication-related osteonecrosis of the jaw (MRONJ).
  
  
  METHODS
  Ten patients (2 men and 8 women; average age, 72.9 yr old) diagnosed with MRONJ were selected. Patients were treated with a PBFP. Data from patients regarding MRONJ stage, defect size, bone exposure after surgery, operation time, admission period, duration of antibiotic therapy, recurrence of disease, and postoperative complications were analyzed retrospectively.
  
  
  RESULTS
  Six patients were diagnosed with MRONJ stage 2, and 4 patients were diagnosed with MRONJ stage 3. The maximum defect in the study was 62 × 18 mm. Among the 10 patients, there was only 1 bony exposure, which occurred on postoperative day 2 after receiving the PBFP. This exposure might have been due to an incomplete resection of the affected bone. There were no severe donor site morbidities, and all patients showed satisfactory healing without incident.
  
  
  CONCLUSIONS
  According to this evaluation, the PBFP effectively covered a relatively large surgical defect. Complications were minimal, and there was no recurrence of bony exposure during follow-up. In conclusion, using the PBFP was a reliable treatment option for the management of denuded bone in patients with MRONJ.
authors.affiliation: Associate Professor, Department of Craniomaxillofacial Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Horatiu
authors.initials: H
authors.lastname: Rotaru
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Korea. Electronic address: omfsmk@gwnu.ac.kr.
authors.forename: Min-Keun
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Associate Professor, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Korea.
authors.forename: Seong-Gon
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Korea.
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Park
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000145:classification / Q000601:surgery*; D002610:Cheek / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008137:Longitudinal Studies; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery; D008439:Maxillary Diseases / Q000601:surgery; D008875:Middle Aged; D061646:Operative Time; D011183:Postoperative Complications; D012008:Recurrence; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000637:transplantation*; D013529:Surgical Wound Dehiscence / Q000209:etiology; D060053:Transplant Donor Site / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents