title: Silver-mediated radical cyclization of alkynoates and α-keto acids leading to coumarins via cascade double C-C bond formation.
abstract: A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via the direct difunctionalization of alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed. This new method is highly efficient and practical, and the starting materials are readily prepared. The present method should provide a useful strategy for the construction of coumarin motifs.
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong P. R. China.
authors.forename: Kelu
authors.initials: K
authors.lastname: Yan
authors.forename: Daoshan
authors.initials: D
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shuai
authors.forename: Qiannan
authors.initials: Q
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D003500:Cyclization; D007651:Keto Acids / Q000737:chemistry*; D015394:Molecular Structure; D018030:Silver Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D007651:Keto Acids; D018030:Silver Compounds; C030123:coumarin