title: Modelling chemotherapy effects on granulopoiesis.
abstract: BACKGROUND
  Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dosing and timing of chemotherapies, pharmaceutical derivative of G-CSF used and individual risk factors. We showed in the past that a pharmacokinetic and -dynamic model of G-CSF and human granulopoiesis can be used to predict the performance of yet untested G-CSF schedules. However, only a single chemotherapy was considered so far.
  
  
  RESULTS
  Model assumptions proved to be feasible in explaining granulotoxicity of 10 different chemotherapeutic drugs or drug-combinations applied in 33 different schedules with and without G-CSF. Risk groups of granulotoxicity were traced back to differences in toxicity parameters.
  
  
  CONCLUSIONS
  We established a comprehensive model of combined G-CSF and chemotherapy action in humans which allows us to predict and compare the outcome of alternative G-CSF schedules. We aim to apply the model in different clinical contexts to optimize and individualize G-CSF treatment.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Schirm
authors.forename: Christoph
authors.initials: C
authors.lastname: Engel
authors.forename: Markus
authors.initials: M
authors.lastname: Loeffler
authors.forename: Markus
authors.initials: M
authors.lastname: Scholz
mesh_terms: D003603:Cytotoxins / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000378:metabolism*; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects* / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological
chemical_list: D003603:Cytotoxins; D016179:Granulocyte Colony-Stimulating Factor