title: Revisiting inflammation in diabetic nephropathy: the role of the Nlrp3 inflammasome in glomerular resident cells.
abstract: Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerular resident cells, in diabetic nephropathy. They also show the role of mitochondrial reactive oxygen species as a mediator to activate the inflammasome in diabetic conditions. Targeting the inflammasome could be a promising approach for diabetic nephropathy.
authors.affiliation: Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sakai
authors.affiliation: Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D003928:Diabetic Nephropathies / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007678:Kidney Glomerulus / Q000166:cytology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes