title: Triterpenoids from Inonotus obliquus and their antitumor activities.
abstract: Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triterpenoids (5-20), including 13 lanostane derivatives, 2 lupanes and 1 oleanane-type triterpene were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. Compounds 6, 8, 18 and 20 exhibited strong cytotoxicity against A549 tumor cell lines, with IC50 values of 2.34, 1.63, 8.39 and 5.39μM, respectively. Seven compounds (3, 9, 10, 12, 18-20) exhibited moderate cytotoxicity against A549, HT29, Hela or L1210 tumor cell lines.
authors.affiliation: Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
authors.forename: Fenqin
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Xingyang Hospital of Traditional Chinese Medicine, Xingyang 450100, China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Mai
authors.affiliation: Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Jianghao
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Xu
authors.affiliation: Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Cui
authors.affiliation: Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: fengqiu20070118@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.affiliation: Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China. Electronic address: hanghang1998@126.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Han
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes
keywords: 3β-Hydroxy-lanosta-8,24-diene-21-al (PubChem CID: 44581610); Antitumor; Betulin (PubChem CID: 72326); Betulinic acid (PubChem CID: 64971); Inonotsuoxide A (PubChem CID: 44422304); Inonotus obliquus; Inonotusane A; Inonotusane B; Inonotusane C; Inotodiol (PubChem CID: 44422314); Lanosteol (PubChem CID: 246983); Oleanolic acid (PubChem CID: 10494); Trametenolic acid (PubChem CID: 12309443); Triterpenoids