title: Incidental gonadal tumors at the time of gonadectomy in women with Swyer syndrome: a case series.
abstract: BACKGROUND
  Swyer syndrome (46XY complete gonadal dysgenesis) is an uncommonly encountered condition in our population. Gonadectomy is recommended upon diagnosis due to a significant risk of malignant transformation of the dysgenetic gonads, typically to dysgerminoma.
  
  
  METHODS
  We present 3 cases of women who underwent gonadectomy following a diagnosis of Swyer syndrome. Two of these patients had dysgerminoma confirmed on histopathology. In particular we discuss the macroscopic appearance of the affected gonads and the further management of each case.
  
  
  CONCLUSIONS
  Individuals with Swyer syndrome require gonadectomy upon diagnosis of their condition, as part of their multidisciplinary management. For treatment of early stage dysgerminoma, surgical resection of the involved gonad and fallopian tube is curative, again highlighting the need for early intervention.
authors.affiliation: Women's and Newborn Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. Electronic address: amie.hanlon@health.qld.gov.au.
authors.forename: Amie J M
authors.initials: AJ
authors.lastname: Hanlon
authors.affiliation: Statewide Paediatric and Adolescent Gynaecology Services, Royal Brisbane and Women's Hospital, University of Queensland School of Medicine, Brisbane, Queensland, Australia.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Kimble
mesh_terms: D000293:Adolescent; D004407:Dysgerminoma / Q000601:surgery*; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications* / Q000601:surgery; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods; D010053:Ovary / Q000473:pathology
keywords: 46 XY; Dysgerminoma; Gonadal dysgenesis; Gonadoblastoma