title: Neuroanatomical mechanism on the effect of distraction in working memory maintenance in patients with schizophrenia.
abstract: This study utilized functional magnetic resonance imaging (fMRI) to discriminate brain activation patterns associated with the effect of distraction during working memory (WM) maintenance for human faces in healthy controls and patients with schizophrenia. Event-related fMRI data were obtained while the subjects performed WM maintenance in a delayed-response WM task with task-irrelevant distracters. Compared with healthy controls, patients showed significantly decreased activities in the superior frontal gyrus, dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex, anterior cingulate cortex, inferior parietal gyrus, and fusiform gyrus during the delayed-response WM task with human face distracters. The blood-oxygen-level-dependent signal changes in the DLPFC were negatively correlated with both of the scores of the Positive Subscale and General Psychopathology Subscale under the Positive and Negative Syndrome Scale during the WM maintenance for the human faces in the patients. This study will be helpful in understanding the neural mechanisms in the general impairment of the inhibition control in schizophrenia.
authors.affiliation: From the Research Institute for Medical Imaging, Chonnam National University Medical School, Gwangju, Republic of Korea (G-WK, G-WJ); the Dept. of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea (Y-CC, J-CY); the Dept. of Radiology, Chonbuk National University Medical School, Jeonju Republic of Korea (G-HC); the Dept. of Psychology, Chonnam National University, Gwangju, Republic of Korea (T-JP); and the Dept. of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju Republic of Korea (G-WJ).
authors.forename: Gwang-Won
authors.initials: GW
authors.lastname: Kim
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Chung
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Yang
authors.forename: Gyung-Ho
authors.initials: GH
authors.lastname: Chung
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Park
authors.forename: Gwang-Woo
authors.initials: GW
authors.lastname: Jeong
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D005145:Face; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs; D010100:Oxygen