title: Effects of whole-body vibration on plasma sclerostin level in healthy women.
abstract: OBJECTIVE
  To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments.
  
  
  METHODS
  Following a pilot study, the pretsent prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application.
  
  
  RESULTS
  The plasma sclerostin level measured at 10 min after the whole-body vibration treatment increased 91% (P = 0.024) on the 1st day and decreased 31.5% (P = 0.03) on the 5th day in the whole-body vibration group. In the control group, there was no change in the plasma sclerostin level at any time. A progressive increase in baseline plasma sclerostin levels during the 5 days of vibration sessions was also found.
  
  
  CONCLUSIONS
  Our study demonstrated that whole-body vibration can change plasma sclerostin levels, and that this change is detectable 10 min after whole-body vibration treatments.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Bağcılar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Çidem
authors.forename: Yunus
authors.initials: Y
authors.lastname: Karakoç
authors.forename: Hakan
authors.initials: H
authors.lastname: Ekmekçi
authors.forename: Suat Hayri
authors.initials: SH
authors.lastname: Küçük
authors.forename: Murat
authors.initials: M
authors.lastname: Uludağ
authors.forename: Kerem
authors.initials: K
authors.lastname: Gün
authors.forename: Safak Sahir
authors.initials: SS
authors.lastname: Karamehmetoğlu
authors.forename: İlhan
authors.initials: İ
authors.lastname: Karacan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D011446:Prospective Studies; D016037:Single-Blind Method; D014732:Vibration; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human