title: Diffuse alveolar hemorrhage after erlotinib combined with concurrent chemoradiotherapy in a patient with esophageal carcinoma.
abstract: Diffuse alveolar hemorrhage (DAH) is a life-threatening clinical pathologic syndrome caused by a variety of diseases. We report a case of DAH related to combination therapy of chemoradiotherapy and erlotinib. As to know, DAH following chemoradiotherapy was only reported among hematopoietic stem cell transplant recipients with hematologic malignancies till now. DAH associated with chemoradiotherapy for oesophageal carcinoma has not been reported. This is the first DAH report on erlotinib-combined chemoradiotherapy for esophageal cancer. The authors believe epidermal growth factor receptor tyrosine kinase inhibitor erlotinib increased the lung injury. Molecular targeted drugs are gradually applied to be combined with chemoradiation, whether this combination will cause the increase of serious adverse reactions need further study. This case can provide certain reference for erlotinib in the treatment. Meanwhile, after long term hormone therapy for DAH, the patient was diagnosed with pneumocystis carinii pneumonia. It reminds us to attach importance to the immunosuppressive diseases after long-term hormone treatment.
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Chuan-Hua
authors.initials: CH
authors.lastname: Zhao
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Rong-Rui
authors.initials: RR
authors.lastname: Liu
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Jian-Zhi
authors.initials: JZ
authors.lastname: Liu
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Fei-Jiao
authors.initials: FJ
authors.lastname: Ge
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Li
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Ye
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Science No. 8 Dongda Street, Fengtai District, Beijing 100071, P. R. China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Xu
keywords: Diffuse alveolar hemorrhage; chemoradiotherapy; erlotinib; esophageal carcinoma