title: [Problems of depressive insomnia].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of antidepressant agomelatine in relation to the normalization of circadian rhythms in a psychiatric outpatient practice.
  
  
  METHODS
  It was an open label, non-comparative observational study of 32 patients 18-55 years during the eight-week therapy of major depressive episode mild or moderate severity. For statistical analysis the obtained results were used software package Excel 97.
  
  
  RESULTS
  On the background of treatment marked improvement in levels of depression and decreased intra-group scores of the indicators of the scale of Leeds. A statistically significant increase in the proportion of responders and remitters is achieved already in the first 2 weeks of therapy.
  
  
  CONCLUSIONS
  Thus, in the course of the study, it was shown that along with antidepressant effects, agomelatine able to synchronize disturbed circadian rhythms and to correct sleep disorders in patients with depression.
authors.forename: E A
authors.initials: EA
authors.lastname: Tarakanova
authors.forename: É G
authors.initials: ÉG
authors.lastname: Ivanchuk
authors.forename: V V
authors.initials: VV
authors.lastname: Rostovshchikov
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008550:Melatonin / Q000819:agonists; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D006993:Hypnotics and Sedatives; D008550:Melatonin; C084711:agomelatine; D009281:Naphthalenes