title: Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N-sulfonyloxaziridines.
abstract: Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Chang-Bin
authors.initials: CB
authors.lastname: Yu
authors.forename: Wen-Xue
authors.initials: WX
authors.lastname: Huang
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D001388:Aziridines; D004852:Epoxy Compounds; D013438:Sulfhydryl Compounds; D010165:Palladium