title: Overexpression of EpCAM and Trop2 in pituitary adenomas.
abstract: We sought to investigate the expression of EpCAM and Trop2 in Pituitary adenomas (PAs) and study the correlation of protein expression with invasiveness, proliferation, clinical functioning, recurrence/progression, and some other factors. We investigated the expression of EpCAM and Trop2 in 74 samples of PAs by immunohistochemistry and made correlative analysis of protein overexpression with clinicopathological parameters. Follow-up data was analyzed for recurrence/progression with Kaplan-Meier method and Multivariate Cox regression analysis. Immunohistochemistry results showed that overexpression rates of EpCAM and Trop2 were 51/74 (68.9%) and 43/74 (58.1%), respectively. For both EpCAM and Trop2, PAs with invasiveness showed a higher overexpression rate than PAs without invasiveness (PEpCAM = 0.001; PTrop2 = 0.006). Nonfunctional Pituitary adenomas (NFPAs) demonstrated a higher EpCAM overexpression than functional Pituitary adenomas (FPAs) (P = 0.026). Both EpCAM and Trop2 overexpression correlated significantly with expression of proliferation factor Ki-67 (PEpCAM = 0.011; PTrop2 = 0.000), but not with gender and age. Follow-up analysis revealed that Trop2 overexpression was a significantly predictive factor for recurrence/progression by means of Kaplan-Meier method d (P = 0.028) and Multivariate Cox regression analysis (P = 0.025). This study reveals that both EpCAM and Trop2 overexpression in PAs correlate significantly with invasiveness and proliferation. EpCAM presents a potential target for differential diagnosis and immunotherapy for NFPAs. Follow-up analysis shows that Trop2 is a predictive factor for recurrence/progression for PAs.
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China ; Shandong University School of Medicine Jinan 250012, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Shandong University School of Medicine Jinan 250012, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Pang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China ; Shandong University School of Medicine Jinan 250012, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China.
authors.forename: Shang-Chen
authors.initials: SC
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xin
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, China-Japan Friendship Hospital Beijing 100029, P. R. China.
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D000071858:Epithelial Cell Adhesion Molecule; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; C499380:TACSTD2 protein, human
keywords: EpCAM; Pituitary adenomas; Trop2