title: Predictors of major improvement after intravenous thrombolysis in acute ischemic stroke.
abstract: BACKGROUND
  Intravenous thrombolysis improves outcomes of stroke patients. The immediate response to thrombolysis is variable and few studies attempted to identify predictors of major neurological improvement (MNI) 24 h following thrombolysis. Our objective is to determine predictors of MNI 24 h following thrombolysis.
  
  
  METHODS
  We reviewed the prospective database of patients treated through our telestroke network and at our institution between November 2008 and June 2012. We included all patients who received IV t-PA and had a 24-h NIHSS score available. Similar to previous studies, we defined MNI as a reduction in NIHSS score by ≥8 points, or a score of 0 or 1 at 24 h. Demographics, risk factors, time to treatment, and clinical and laboratory data, were compared between MNI present or absent. Baseline predictors were compared using t- and Fisher's exact tests, and outcomes using multivariate logistic regression analysis.
  
  
  RESULTS
  Out of 316 patients, 306 had 24-h NIHSS scores and 38% of them experienced MNI. Patients with MNI were less likely to be older than 80 years (16% vs. 29%, p = 0.008) and to have atrial fibrillation (9% vs. 24%, p = 0.001) compared to those without; we found no other predictors of MNI. After adjusting for baseline demographics and risk factors, age less than 80 years (OR = 1.9, 95% CI 1.1-3.6) and absence of atrial fibrillation (OR = 3.0, 95% CI: 1.4-6.2) predicted MNI.
  
  
  CONCLUSIONS
  Major neurological improvement within 24 h after thrombolysis is more likely in younger patients and those without atrial fibrillation.
authors.affiliation: a 1 Division of Stroke and Cerebrovascular Diseases, Neurology Department, Columbia University Medical Center, New York, NY, USA.
authors.forename: Shadi
authors.initials: S
authors.lastname: Yaghi
authors.affiliation: b 2 Department of Neurology, University of Arkansas for Medical Sciences, Litte Rock, AR, USA.
authors.forename: Archana
authors.initials: A
authors.lastname: Hinduja
authors.affiliation: b 2 Department of Neurology, University of Arkansas for Medical Sciences, Litte Rock, AR, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bianchi
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
keywords: atrial fibrillation; ischemic stroke; major neurological improvement; outcome; thrombolysis