title: Low dose furazolidone for eradication of H- pylori instead of clarithromycin: a clinical trial.
abstract: BACKGROUND
  Helicobacter pylori infection is a common chronic human bacterial infection. Triple- therapy regimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole is commonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradication rate. The present study was designed to evaluated efficacy of low dose furazolidone with amoxicillin and omeprazole for eradication of H- pylori.
  
  
  METHODS
  One hundred twenty patients with non- ulcer dyspepsia or peptic ulcer confirmed by upper GI endoscopy, plus H- pylori infection confirmed by rapid urease test were included in the study. They were randomly divided into two groups, and then received clarithromycin, amoxicillin, and omeprazole, or furazolidone (100 mg PO bid), amoxicillin, and omeprazole. They were evaluated using urea breath test at the end of the study.
  
  
  RESULTS
  The eradication rates were 57.6% and 78.8% in clarithromycin and furazolidone groups, respectively. Their difference was statistically significant (P value 0.013). No side effect was seen in the furazolidone group.
  
  
  CONCLUSIONS
  Low dose furazolidone rather than clarithromycin can be used as low- cost and effective drug for eradication of H- pylori, in combination with amoxicillin and omeprazole.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Hajaghamohammadi
authors.forename: Seyyed Hossein
authors.initials: SH
authors.lastname: Safiabadi Tali
authors.forename: Rasoul
authors.initials: R
authors.lastname: Samimi
authors.forename: Sonia
authors.initials: S
authors.lastname: Oveisi
authors.affiliation: Qazvin university of medical sciences. dr.houshmand@yahoo.com.
authors.forename: Amir Mohammad
authors.initials: AM
authors.lastname: Kazemifar
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D001944:Breath Tests; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005664:Furazolidone / Q000008:administration & dosage*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000897:Anti-Ulcer Agents; D005664:Furazolidone; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole