title: IgM Myeloma or Waldenstrom's Macroglobulinemia Is the Big Question?
abstract: Although critical from therapeutic and prognostic perspectives, differentiating IgM Myeloma (MM) from Waldenstrom's macroglobulinemia (WM) is fraught with failure. WM can usually be distinguished from IgM MM by the lymphoplasmacytic versus pure plasmacytic morphology, absent versus present lytic bone lesions, and immunophenotypic findings. However, all these features have their own limitations; hence, it requires constant vigilance and periodic re-evaluation. Here we describe a case of a 70-year-old woman initially diagnosed as smoldering IgM MM, who eventually turned out to have WM.
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Srujitha
authors.initials: S
authors.lastname: Murukutla
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Muniba
authors.initials: M
authors.lastname: Naqi
authors.affiliation: Department of Internal Medicine, University of Science and Technology, Bangladesh, Chittagong.
authors.forename: Shradha
authors.initials: S
authors.lastname: Pant
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Shiksha
authors.initials: S
authors.lastname: Kedia
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Terenig
authors.initials: T
authors.lastname: Terjanian