title: Predictive value of the complement system for sepsis-induced disseminated intravascular coagulation in septic patients in emergency department.
abstract: OBJECTIVE
  To investigate changes in circulating complement component C3, membrane attack complex (MAC), and mannose-binding lectin (MBL) in patients with sepsis-induced disseminated intravascular coagulation (DIC).
  
  
  METHODS
  Adult septic patients admitted to the emergency department (ED) of Beijing Chao-Yang Hospital were enrolled. A DIC score of 5 or higher was considered sepsis-induced DIC. Circulating C3, MAC, and MBL levels were detected on ED arrival and compared between patients with and without DIC. The predictive value of C3, MAC, and MBL for sepsis-induced DIC at ED arrival and development of DIC after admission were assessed by receiver operating characteristic curve and logistic regression.
  
  
  RESULTS
  We enrolled 267 septic patients between February and December 2013. Complement 3, MAC, and MBL were higher in the DIC group (P < .01). Membrane attack complex was the independent predictor of sepsis-induced DIC. The area under the curve of MAC in predicting sepsis-induced DIC was 0.793. During hospitalization, 25 patients without DIC at enrollment developed DIC. Membrane attack complex and Sequential Organ Failure Assessment independently predicted progress to DIC. The area under the curve of MAC was 0.741.
  
  
  CONCLUSIONS
  Complement 3, MAC, and MBL were significantly increased in septic patients with DIC. Membrane attack complex independently predicted sepsis-induced DIC and development of DIC after ED admission.
authors.affiliation: Emergency Department of Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing 100020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Emergency Department of Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing 100020, China.
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Emergency Department of Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing 100020, China. Electronic address: lcscyyy@wo.cn.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003176:Complement C3 / Q000378:metabolism*; D015938:Complement Membrane Attack Complex / Q000378:metabolism*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D018805:Sepsis / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D003176:Complement C3; D015938:Complement Membrane Attack Complex; D037601:Mannose-Binding Lectin
keywords: Complement; Disseminated intravascular coagulation; Sepsis