title: Serum prolidase activity is associated with non-diabetic metabolic syndrome.
abstract: OBJECTIVE
  The aim of this study was to determine the role of serum prolidase activity and the possible association with oxidative stress parameters in non-diabetic metabolic syndrome.
  
  
  METHODS
  30 obese patients without metabolic syndrome (MetS), 34 non-diabetic obese patients with MetS, and 23 volunteer control subjects were enrolled in the study. Fasting plasma glucose (FPG), plasma glucose following 75 g glucose administration, high-density lipoprotein- cholesterol (HDL-C), high-density lipoprotein- cholesterol (LDL-C), total cholesterol, triglyceride (TG), total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and prolidase activities of all subjects were analyzed.
  
  
  RESULTS
  Prolidase levels was significantly higher in MetS group compared to both obese and control groups (p < 0.001 and p < 0.05 respectively). Prolidase was also higher in the obese group than in the control group (p < 0.05). Prolidase was negatively correlated with TAS and HDL-C (r = -0,362, p < 0.001; r = -0.320, p < 0.01, respectively) and positively correlated with BMI, weight, waist-c, SBP, DBP, TG, TC, LDL-C.
  
  
  CONCLUSIONS
  Prolidase activity may have a role in the pathogenesis of metabolic syndrome.
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Tabur
authors.affiliation: Faculty of Medicine, Department of Medical Pharmacology, Harran University, 63300 Sanliurfa, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Oguz
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Harran University, 63300 Sanliurfa, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Eren
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Gaziantep University, 27100 Sahinbey, Gaziantep Turkey.
authors.forename: Esen
authors.initials: E
authors.lastname: Savas
authors.affiliation: Faculty of Medicine, Department of Clinical Biochemistry, Harran University, 63300 Sanliurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Harran University, 63300 Sanliurfa, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Sabuncu
keywords: Metabolic syndrome; Non-diabetic; Obesity; Prolidase