title: Risk of trastuzumab-related cardiotoxicity in early breast cancer patients: a prospective observational study.
abstract: OBJECTIVE
  In the present study, we investigated the incidence of cardiotoxicity within 5 years of trastuzumab treatment and evaluated potential risk factors in clinical practice.
  
  
  METHODS
  The study cohort included 415 patients diagnosed with early breast cancer (EBC). Cardiotoxicity incidence was evaluated in patients receiving trastuzumab and those who did not. Multivariate Cox proportional hazards regression models were used to estimate hazard ratios and 95% confidence intervals of potential risk factors for trastuzumab-related cardiotoxicity after appropriate adjustments.
  
  
  RESULTS
  Incidence of cardiotoxicity in patients treated with trastuzumab was significantly higher than that in controls (23.7% vs. 10.8%, p<0.001). This result was adjusted for factors that might increase the risk of cardiotoxicity, such as history of coronary artery diseases or the use of anthracyclines for more than four cycles.
  
  
  CONCLUSIONS
  Our findings indicated that treatment with trastuzumab was strongly associated with cardiotoxicity in EBC patients.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Zefei
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Shuanghong
authors.initials: S
authors.lastname: Lv
authors.affiliation: Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Zhang
keywords: Breast neoplasms; Cardiotoxicity; Trastuzumab