title: Regulatory effect of caffeine on the acute and the chronic pain and its possible mechanisms.
abstract: Caffeine,as an important component of refreshment beverage,has been used for a long history. In recent years,its effect on pain relief has been widely explored. As one of nonselective adenosine receptor blockers,caffeine plays different roles in the central and peripheral pain. This review explores the roles of caffeine in acute and chronic pain and the potential mechanisms.
authors.affiliation: Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yu-Guan
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Le
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: Huang
mesh_terms: D000241:Adenosine / Q000037:antagonists & inhibitors / Q000378:metabolism; D002110:Caffeine / Q000494:pharmacology* / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000494:pharmacology* / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy; D006801:Humans; D010146:Pain / Q000188:drug therapy*
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine; D000241:Adenosine