title: [Reproductive problems in women with PCOS, the impact of PAL-1 CARRIERS OF 4G PAI -1 polymorphism and BMI].
abstract: Approximately 7-12% of women in reproductive age are affected by PCOS[2] and 40 to 70 percent of them are overweight contributing to the clinical picture of PCOS and increased reproductive and metabolic disorder. In order to investigate the role of PAl-1 as a possible risk factor for the development of PCOS a group of 67 women with polycystic ovarian disease and 70 healthy controls were investigated for levels of PAI-1 and carriage of the promoter polymorphism 675 4G/5G in gene of PAl-1. The results of the DNA analysis showed a high carriage of polymorphism 675 4G/4G in promoter of PAI-1 gene in women with PCOS but not as significant (OR = 1.6645, p = 0.141). Serum levels of PAI-1 were significantly higher in total group of patients compared to controls. The levels of PAI-1 is correlated with carriage of 675 4G/5G polymorphism in the gene for PAI-1 (R = 0.534, p = 0.03) as well as wih BMI, like correlation coefficients were higher in the group with PCOS (0.572, p = 0.04). Data from the disease history showed a higher percentage of women with reproductive problems: 61.5% (early pregnancy loss and infertility) significantly higher in the group with PCOS (70.1% compared to 54.1%). The carriers of polymorphism 4G are at greater risk for early pregnancy loss than those with 5G (61.45% as compared to 36.8%), which confirms that carriage of the polymorphism 4G/5G 675 gene PAI-1 has a specific in multifactorial pathogenesis and expression of PCOS.
authors.forename: R
authors.initials: R
authors.lastname: Komsa-Penkova
authors.forename: G
authors.initials: G
authors.lastname: Golemanov
authors.forename: G
authors.initials: G
authors.lastname: Georgieva
authors.forename: N
authors.initials: N
authors.lastname: Slavov
authors.forename: K
authors.initials: K
authors.lastname: Popovski
authors.forename: P
authors.initials: P
authors.lastname: Ivanov
authors.forename: K
authors.initials: K
authors.lastname: Kovacheva
authors.forename: M
authors.initials: M
authors.lastname: Atanasova
authors.forename: A
authors.initials: A
authors.lastname: Blajev
mesh_terms: D000328:Adult; D015992:Body Mass Index; D020964:Embryo Loss / Q000097:blood / Q000209:etiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D012098:Reproduction; D055815:Young Adult
chemical_list: D017395:Plasminogen Activator Inhibitor 1