title: [Th1/2-balance shift during acute graft-versus-host reaction developing against the background of experimental hyperlipidemia].
abstract: OBJECTIVE
  Evaluate the effect of experimental hyperlipidemia on the intensity of development of acute graft-versus-host reaction (GVHR) in mice.
  
  
  METHODS
  Half-allogenic system C57Bl/6 (C57Bl/6 x DBA/2)F1 was used as a laboratory model of acute GVHR. Experimental hyperlipidemia in mice-recipients was induced by repeated administration of poloxamer 407.
  
  
  RESULTS
  Lethality in the group of mice with acute GVHR developing against the background of preceding hyperlipidemia was significantly higher (70% at day 50 of GVHR development) compared with control group with acute GVHR (50% lethality at day 50). Such effect on the degree of severity of acute GVHR induced under the conditions of hyperlipidemia is confirmed by a more pronounced destruction of thymus in mice of the group with previously induced hyperlipidemia.
  
  
  CONCLUSIONS
  Preceding hyperlipidemia induced by administration of poloxamer 407 shifts Th1/2- balance in the development of acute GVHR towards Th1. Mechanisms of this effect and possible role of nuclear LXR receptors in regulation of immune reactions are discussed.
authors.forename: N N
authors.initials: NN
authors.lastname: Volskiĭ
authors.forename: O M
authors.initials: OM
authors.lastname: Perminova
authors.forename: O P
authors.initials: OP
authors.lastname: Kolesnikova
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D006087:Graft vs Host Reaction / Q000276:immunology*; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D051379:Mice; D020442:Poloxamer / Q000633:toxicity; D013154:Spleen / Q000276:immunology / Q000473:pathology; D058408:Th1-Th2 Balance; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: D020442:Poloxamer