title: Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial.
abstract: BACKGROUND
  Opioid-induced cough during induction of general anesthesia is a common phenomenon. Dezocine, a partial μ-receptors agonist and κ-receptors antagonist, has been documented effectively suppressing fentanyl-induced cough in general anesthesia induction. However, the effect of dezocine on sufentanil-induced cough is still unknown.
  
  
  METHODS
  A total of 370 patients (American Society of Anesthesiologists physical status I-II), aged 18-70 years, undergoing elective surgery, were randomly divided into a control group (group C) and a dezocine group (group D) (n=185 in each group). Patients received dezocine 0.1mg/kg or an equal volume of 0.9% normal saline 2 min prior to intravenous sufentanil (0.5 μg/kg). The incidence and reflex degree of cough in patients were evaluated within 2 min after the injection of sufentanil in anesthesia induction period.
  
  
  RESULTS
  No patient in group D had cough and 59 patients in group C had cough (severity of cough: mild, 7%; moderate, 11.4%; severe, 13.5%). The occurrence and reflex degree of cough in group D was significantly lower than that in group C (P=0.000). The highest heart rate (HR) and invasive blood pressure (IBP) values were higher in group C than those in group D (P<0.01) within 2 min after sufentanil administration, althought these values remained within safe limits.
  
  
  CONCLUSIONS
  The results of current study suggest that administration of Dezocine 0.1mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general anesthesia induction in patients.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Xue-Sheng
authors.initials: XS
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Guang-Hong
authors.initials: GH
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Shen
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Xin-Qi
authors.initials: XQ
authors.lastname: Cheng
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Anhui, China. Electronic address: ay_guew_mz@163.com.
authors.forename: Er-Wei
authors.initials: EW
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000768:Anesthesia, General / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000627:therapeutic use*; D003371:Cough / Q000139:chemically induced* / Q000517:prevention & control*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000187:drug effects; D017409:Sufentanil / Q000009:adverse effects*; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D019086:Bridged Bicyclo Compounds, Heterocyclic; D013764:Tetrahydronaphthalenes; D017409:Sufentanil; C010827:dezocine
keywords: Dezocine; General anesthesia induction; Opioid induced cough; Randomized controlled trial