title: Mitochondrial protein quality control: the mechanisms guarding mitochondrial health.
abstract: CONCLUSIONS
  Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with aging. A set of evolutionary conserved mechanisms known as mitochondrial quality control (MQC) is involved in recognition and correction of the mitochondrial proteome.
  
  
  BACKGROUND
  Here, we review current knowledge and latest developments in MQC. We particularly focus on the proteolytic aspect of MQC and its impact on health and aging.
  
  
  RESULTS
  While our knowledge about MQC is steadily growing, critical gaps remain in the mechanistic understanding of how MQC modules sense damage and preserve mitochondrial welfare, particularly in higher organisms.
  
  
  CONCLUSIONS
  Delineating how coordinated action of the MQC modules orchestrates physiological responses on both organellar and cellular levels will further elucidate the current picture of MQC's role and function in health, cellular stress, and degenerative diseases.
authors.affiliation: 1 Department of Biochemistry, University of Nebraska-Lincoln , Lincoln, Nebraska.
authors.forename: Iryna
authors.initials: I
authors.lastname: Bohovych
authors.forename: Sherine S L
authors.initials: SS
authors.lastname: Chan
authors.forename: Oleh
authors.initials: O
authors.lastname: Khalimonchuk
mesh_terms: D000375:Aging / Q000378:metabolism*; D006262:Health; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000096:biosynthesis*
chemical_list: D024101:Mitochondrial Proteins