title: Blood pressure, magnesium and other mineral balance in two rat models of salt-sensitive, induced hypertension: effects of a non-peptide angiotensin II receptor type 1 antagonist.
abstract: The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increased arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility, and vascular tone. To evaluate the relationship between high BP induced by a high sodium (Na) diet and Mg, and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II infused and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SS rats fed a high Na diet had a slow pressor response, accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K balances. Mg metabolism maybe considered a possible defect in this strain of rat that may contribute to hypertension.
authors.affiliation: Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Biofísica y Bioquímica, Laboratorio de Fisiología Molecular, Altos de Pipe, Estado Miranda, Venezuela.
authors.forename: Lusliany Josefina
authors.initials: LJ
authors.lastname: Rondón
authors.affiliation: IVIC, Centro de Química, Laboratorio de Química Analítica, Altos de Pipe, Estado Miranda, Venezuela.
authors.forename: Eunice
authors.initials: E
authors.lastname: Marcano
authors.affiliation: IVIC, Centro de Química, Laboratorio de Química Analítica, Altos de Pipe, Estado Miranda, Venezuela.
authors.forename: Fátima
authors.initials: F
authors.lastname: Rodríguez
authors.affiliation: Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Biofísica y Bioquímica, Laboratorio de Fisiología Molecular, Altos de Pipe, Estado Miranda, Venezuela.
authors.forename: Jesús Rafael
authors.initials: JR
authors.lastname: del Castillo
mesh_terms: D000804:Angiotensin II / Q000502:physiology / Q000633:toxicity; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D006929:Hyperaldosteronism / Q000209:etiology; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D019808:Losartan / Q000627:therapeutic use*; D008274:Magnesium / Q000097:blood / Q000502:physiology*; D008297:Male; D008903:Minerals / Q000097:blood / Q000652:urine; D059606:Polydipsia / Q000139:chemically induced; D011897:Random Allocation; D051381:Rats; D020303:Rats, Inbred Dahl; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000502:physiology*; D017673:Sodium Chloride, Dietary / Q000009:adverse effects
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D008903:Minerals; D017673:Sodium Chloride, Dietary; D000804:Angiotensin II; D008274:Magnesium; D019808:Losartan
keywords: Dahl salt-sensitive rats; angiotensin II; angiotensin-II type-1 receptor; losartan; magnesium; minerals