title: [Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT].
abstract: Endocrine disruptors are exogenous substances that exhibit hormone-like action and consequently disrupt homeostatic action of endogenous hormones. DDT is the most common disruptor. The objective was to evaluate changes in thyroid hormone secretion after long-term exposure to low doses of DDT. The experiment was performed on male Wistar rats. The rats were given DDT at doses of 1.89±0.86 мg/kg/day and 7.77±0.17 мg/kg/day for 6 and 10 weeks. Dose dependent increase of serum total thyroxine, total triiodthyronine, and thyroid peroxidase was revealed after 6 weeks exposure. After 10 weeks free thyroxine secretion was reduced. Such alterations of the thyroid status are typical for iodine deficient goiter. The data obtained indicate that the main mechanism of DDT action includes disruption of thyroxine secretion by thyrocytes, but not inhibition of deiodinase activity and decrease of blood thyroid binding proteins.
authors.affiliation: Scientific research Institute of Human Morphology.
authors.forename: N V
authors.initials: NV
authors.lastname: Iaglova
authors.affiliation: Scientific research Institute of Human Morphology.
authors.forename: V V
authors.initials: VV
authors.lastname: Iaglov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003634:DDT / Q000633:toxicity*; D004334:Drug Administration Schedule; D052244:Endocrine Disruptors / Q000633:toxicity*; D007453:Iodide Peroxidase / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
chemical_list: D052244:Endocrine Disruptors; D014284:Triiodothyronine; D013972:Thyrotropin; D003634:DDT; D007453:Iodide Peroxidase; D013974:Thyroxine
keywords: DDT; endocrine disruptors; thyroid gland; thyroid hormones