title: Further understanding of tau phosphorylation: implications for therapy.
abstract: Tau is a brain microtubule-associated protein that regulates microtubule structure and function. Prominent tau neurofibrillary pathology is a common feature in a number of neurodegenerative disorders collectively referred to as tauopathies, the most common of which is Alzheimer's disease. Beyond its classical role as a microtubule-associated protein, recent advances in our understanding of tau cellular functions have unveiled novel important tau cellular functions that may also play a pivotal role in pathogenesis and render novel targets for therapeutic intervention. Regulation of tau behavior and function under physiological and pathological conditions is mainly achieved through post-translational modifications, especially phosphorylation, which has significant implications for the development of novel therapeutic approaches in a number of neurodegenerative disorders.
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo 5, 28041-Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Medina
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010766:Phosphorylation / Q000187:drug effects; D024801:Tauopathies / Q000188:drug therapy* / Q000378:metabolism; D016875:tau Proteins / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; D016875:tau Proteins
keywords: Alzheimer; aggregation; dementia; kinases; memory; neurodegeneration; neurofibrillary tangles; phosphorylation; tau; tauopathies