title: The RTEL1 rs6010620 polymorphism and glioma risk: a meta-analysis based on 12 case-control studies.
abstract: BACKGROUND
  The association between the RTEL1 rs6010620 single nucleotide polymorphism (SNP) and glioma risk has been extensively studied. However, the results remain inconclusive. To further examine this association, we performed a meta-analysis.
  
  
  METHODS
  A computerized search of the PubMed and Embase databases for publications regarding the RTEL1 rs6010620 polymorphism and glioma cancer risk was performed. Genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analyses, tests of heterogeneity, cumulative meta-analyses, and assessments of bias were performed in our meta-analysis.
  
  
  RESULTS
  Our meta-analysis confirmed that risk with allele A is lower than with allele G for glioma. The A allele of rs6010620 in RTEL1 decreased the risk of developing glioma in the 12 case-control studies for all genetic models: the allele model (OR=0.752, 95%CI: 0.715-0.792), the dominant model (OR=0.729, 95%CI: 0.685-0.776), the recessive model (OR=0.647, 95%CI: 0.569-0.734), the homozygote comparison (OR=0.528, 95%CI: 0.456-0.612), and the heterozygote comparison (OR=0.761, 95%CI: 0.713-0.812).
  
  
  CONCLUSIONS
  In all genetic models, the association between the RTEL1 rs6010620 polymorphism and glioma risk was significant. This meta-analysis suggests that the RTEL1 rs6010620 polymorphism may be a risk factor for glioma. Further functional studies evaluating this polymorphism and glioma risk are warranted.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, China E-mail : jintb@nwu.edu.cn, cchen898@nwu.edu.cn.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Du
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Geng
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Chen
authors.forename: Tian-Bo
authors.initials: TB
authors.lastname: Jin
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D004265:DNA Helicases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D044465:White People / Q000235:genetics
chemical_list: C532890:RTEL1 protein, human; D004265:DNA Helicases