title: The role of microRNAs in skeletal muscle health and disease.
abstract: Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.
authors.affiliation: Center for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Kirby
authors.affiliation: Center for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Chaillou
authors.affiliation: Center for Muscle Biology, University of Kentucky, Lexington, KY, USA, 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: McCarthy
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D024510:Muscle Development / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009133:Muscular Atrophy / Q000503:physiopathology; D009135:Muscular Diseases / Q000503:physiopathology*
chemical_list: D035683:MicroRNAs