title: [Recent advances of studies on the therapy-related myelodysplastic syndromes/acute myeloid leukemia].
abstract: Therapy-related myelodysplasia syndromes/acute myeloid leukemia (t-MDS/AML) is a clinical syndrome occurring as a late complication after chemotherapy and (or) radiotherapy, attracting much more attention owing to the improved treatment agents and longer survival of many treated patients. According to the WHO classification of 2008, t-MDS/AML is a serious complication of chemotherapy or radiotherapy given to a malignant or nonmalignant condition consisting of t-AML, t-MDS and t-MDS/myeloproliferative diseases (t-MDS/MPD). This review mainly focuses on the pathogenesis, relationship with primary tumour, treatment and prognosis of t-MDS/AML.
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institue and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Chan-Juan
authors.initials: CJ
authors.lastname: Li
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institue and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. E-mail: yizhuozhang111@163.com.
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D009196:Myeloproliferative Disorders; D016609:Neoplasms, Second Primary; D011379:Prognosis