title: Metastatic breast cancer presenting as detrusor overactivity.
abstract: Breast carcinoma metastatic to the bladder is rare and accounts for approximately 3% of all secondary bladder neoplasms. We examine a case of breast cancer metastatic to the bladder with normal findings at cystoscopy. A 53-year-old woman with a history of breast carcinoma presented with a 6-month history of severe urgency and urgency incontinence. Treatment with multiple antimuscarinic therapies was unsuccessful. Vaginal examination demonstrated a non-mobile uterus with a suggestion of parametrial thickening. Urodynamic studies confirmed detrusor overactivity. CT showed a thickened bladder wall and cystoscopy revealed normal bladder mucosa with reduced bladder capacity. Bladder biopsies identified a poorly differentiated adenocarcinoma with strong oestrogen receptor staining. This was reported as a secondary deposit from a primary breast malignancy. The patient is currently under the care of the breast team and undergoing palliative chemotherapy.
authors.affiliation: Department of Women's Health, Medway Maritime Hospital, Kent, UK.
authors.forename: Aswini Aparna
authors.initials: AA
authors.lastname: Balachandran
authors.affiliation: Medway Maritime Hospital, Kent, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Duckett
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D003558:Cystoscopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D053201:Urinary Bladder, Overactive / Q000175:diagnosis* / Q000209:etiology; D014549:Urinary Incontinence / Q000175:diagnosis* / Q000209:etiology; D014563:Urodynamics