title: Enterovirus D68: a clinically important respiratory enterovirus.
abstract: Seasonal peaks of viral respiratory illnesses are common during late summer and early fall and have often been attributed to human rhinovirus. In the fall of 2014, the number of children hospitalized with severe lower respiratory symptoms and asthma suddenly increased, and the children tested positive by sequencing for enterovirus D68 (EV-D68). As the outbreak unfolded, a possible association was also observed between EV-D68 infection, polio-like acute flaccid paralysis, and cranial neuropathy in children.
authors.affiliation: Center for Pediatric Infectious Diseases, Pediatric Institute, and Children's Hospital, Cleveland Clinic; Associate Professor of Pediatrics, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Foster
authors.affiliation: Director, Center for Pediatric Neurology, Pediatric Institute, and Children's Hospital, Cleveland Clinic.
authors.forename: Neil
authors.initials: N
authors.lastname: Friedman
authors.affiliation: Center for Pediatric Pulmonary Medicine, Pediatric Institute, and Children's Hospital, Cleveland Clinic; Associate Professor of Pediatrics, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
authors.forename: John
authors.initials: J
authors.lastname: Carl
authors.affiliation: Professor and Chair, Cleveland Clinic Pediatric Institute; Physician in Chief, Cleveland Clinic Children's Hospital; President, Cleveland Clinic Children's Hospital for Rehabilitation piedimg@ccf.org.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piedimonte
mesh_terms: D002648:Child; D030016:Enterovirus D, Human / Q000502:physiology; D004769:Enterovirus Infections / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000821:virology*