title: The Pattern of Brain Amyloid Load in Posterior Cortical Atrophy Using (18)F-AV45: Is Amyloid the Principal Actor in the Disease?
abstract: BACKGROUND
  Posterior cortical atrophy (PCA) is characterized by progressive higher-order visuoperceptual dysfunction and praxis declines. This syndrome is related to a number of underlying diseases, including, in most cases, Alzheimer's disease (AD). The aim of this study was to compare the amyloid load with (18)F-AV45 positron emission tomography (PET) between PCA and AD subjects.
  
  
  METHODS
  We performed (18)F-AV45 PET, cerebrospinal fluid (CSF) biomarker analysis and a neuropsychological assessment in 11 PCA patients and 12 AD patients.
  
  
  RESULTS
  The global and regional (18)F-AV45 uptake was similar in the PCA and AD groups. No significant correlation was observed between global (18)F-AV45 uptake and CSF biomarkers or between regional (18)F-AV45 uptake and cognitive and affective symptoms.
  
  
  CONCLUSIONS
  This (18)F-AV45 PET amyloid imaging study showed no specific regional pattern of cortical (18)F-AV45 binding in PCA patients. These results confirm that a distinct clinical phenotype in amnestic AD and PCA is not related to amyloid distribution.
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Beaufils
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Maria Joao
authors.initials: MJ
authors.lastname: Ribeiro
authors.affiliation: CIC-IT INSERM 0806, Tours, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Vierron
authors.affiliation: INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Johnny
authors.initials: J
authors.lastname: Vercouillie
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Dufour-Rainfray
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Cottier
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Karl
authors.initials: K
authors.lastname: Mondon
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Guilloteau
authors.affiliation: CHRU Bretonneau, Université François Rabelais de Tours, France ; INSERM U930, Imagerie et Cerveau, Université François Rabelais de Tours, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hommet
keywords: Alzheimer's disease; Amyloid; Biomarker; Positron emission  tomography; Posterior cortical atrophy