title: Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis.
abstract: OBJECTIVE
  This study was aimed to determine the relationship of alcohol-metabolizing enzymes ADH2, ADH3, and ALDH2 polymorphisms with the susceptibility to alcoholic chronic pancreatitis (ACP).
  
  
  METHODS
  Meta-analyses that evaluated the association of ADH2, ADH3, and ALDH2 variations with ACP were performed.
  
  
  RESULTS
  Eight case-control studies were selected for analysis. The overall data revealed a significant association of ADH2 polymorphism (OR=1.56, 95% CI=1.42-1.72, P=0.000 for dominant model; OR=1.63, 95% CI=1.55-1.71, P=0.000 for homozygote comparison model; OR=1.11, 95% CI=1.01-1.22, P=0.030 for allelic contrast model), ADH3 polymorphism (OR=0.95, 95% CI=0.86-1.06, P=0.389 for dominant; OR=0.64, 95% CI=0.44-0.93, P=0.020 for homozygote comparison; and OR=0.87, 95% CI=0.77-0.99, P=0.039 for allelic contrast model) and ALDH2 polymorphism (OR=0.57, 95% CI=0.40-0.81, P=0.002 for dominant; OR=0.50, 95% CI=0.23-1.08, P=0.079 for homozygote comparison; and OR=0.58, 95% CI=0.41-0.84, P=0.003 for allelic contrast model) with ACP risk. The subgroup analyses suggested that the variant ADH2*2/*2+*1/*2, ADH2*2/*2 genotype and ADH2*2 allele significantly increased ACP risk among Asian individuals; the variant ADH3*2/*2 genotype and ADH3*2 allele significantly decreased ACP risk among non-Asian individuals; and the variant ALDH2*2/*2+*1/*2 genotype and ALDH2*2 allele significantly decreased ACP risk among Asians.
  
  
  CONCLUSIONS
  ADH2, ADH3 and ALDH2 polymorphisms may be susceptibility facts of ACP, and it may be ethnic and race-dependent.
authors.affiliation: ICU Center, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China. Electronic address: zhongyanjun2@163.com.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Respiratory, Anhui Provincial Hospital, No. 17 Luyang Road, Hefei 230011, Anhui, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Pediatrics, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China.
authors.forename: Runmei
authors.initials: R
authors.lastname: Zou
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China.
authors.forename: Mou
authors.initials: M
authors.lastname: Peng
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D000431:Ethanol / Q000493:pharmacokinetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019512:Pancreatitis, Alcoholic / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D000431:Ethanol; C489332:ADH1B protein, human; C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000071396:Aldehyde Dehydrogenase, Mitochondrial
keywords: ADH2; ADH3; ALDH2; Alcoholic chronic pancreatitis; Pancreatitis crónica alcohólica; Polimorfismo; Polymorphism