title: Respiratory supercomplexes: plasticity and implications.
abstract: The plasticity model of the electron transport chain has slowly begun to replace both the liquid model of free complexes and the solid model of supercomplexes. The plasticity model predicts that respiratory complexes exist and function both as single complexes and as supercomplexes. The advantages of this system is an electron transport train which is able to adapt to changes in its environment. This review will investigate the current body of work on supercomplexes including their assembly, regulation, and plasticity, and particularly their role in the generation of reactive oxygen species and aging.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
authors.forename: Christina Ann-Marie
authors.initials: CA
authors.lastname: Porras
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
authors.forename: Yidong
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D004579:Electron Transport; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species