title: Dexamethasone intravitreal implant for pseudophakic cystoid macular edema in patients with diabetes.
abstract: OBJECTIVE
  Diabetic patients are at a higher risk of developing pseudophakic cystoid macular edema (PCME) after cataract surgery. This study evaluated the effect of dexamethasone intravitreal implant (DEX Implant 0.7 mg, Ozurdex; Allergan, Irvine, CA) in diabetic patients with PCME.
  
  
  METHODS
  In this prospective case series, six patients with diabetes who developed PCME despite topical anti-inflammatory therapy were treated with a single dexamethasone implant. Outcome measures included best corrected visual acuity (BCVA) and central subfoveal thickness.
  
  
  RESULTS
  The mean increase in BCVA from baseline to day 180 was 14 letters (P = .03); four of six patients (67%) achieved greater than 10-letter improvement in BCVA. The mean decrease in central subfoveal thickness was 100 µm (P < .01 vs baseline) by day 30 and 72 µm by day 180 (P = .004).
  
  
  CONCLUSIONS
  A dexamethasone implant may be an effective treatment for diabetic patients who develop pseudophakic cystoid macular edema after cataract surgery.
authors.forename: Rahul N
authors.initials: RN
authors.lastname: Khurana
authors.forename: James D
authors.initials: JD
authors.lastname: Palmer
authors.forename: Travis C
authors.initials: TC
authors.lastname: Porco
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wieland
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage*; D048909:Diabetes Complications; D003930:Diabetic Retinopathy / Q000209:etiology / Q000503:physiopathology; D004343:Drug Implants; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D019654:Lens Implantation, Intraocular; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D019591:Pseudophakia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone