title: Dosimetric experience with 2 commercially available multilumen balloon-based brachytherapy to deliver accelerated partial-breast irradiation.
abstract: The purpose of this work was to report dosimetric experience with 2 kinds of multilumen balloon (MLB), 5-lumen Contura MLB (C-MLB) and 4-lumen MammoSite MLB (MS-MLB), to deliver accelerated partial-breast irradiation, and compare the ability to achieve target coverage and control skin and rib doses between 2 groups of patients treated with C-MLB and MS-MLB brachytherapy. C-MLB has 5 lumens, the 4 equal-spaced peripheral lumens are 5 mm away from the central lumen. MS-MLB has 4 lumens, the 3 equal-spaced peripheral lumens are 3 mm away from the central lumen. In total, 43 patients were treated, 23 with C-MLB, and 20 with MS-MLB. For C-MLB group, 8 patients were treated with a skin spacing < 7 mm and 12 patients with rib spacing < 7 mm. For MS-MLB group, 2 patients were treated with a skin spacing < 7 mm and 5 patients with rib spacing < 7 mm. The dosimetric goals were (1) ≥ 95% of the prescription dose (PD) covering ≥ 95% of the target volume (V(95%) ≥ 95%), (2) maximum skin dose ≤ 125% of the PD, (3) maximum rib dose ≤ 145% of the PD (if possible), and (4) the V(150%) ≤ 50 cm(3) and V(200%) ≤ 10 cm(3). All dosimetric criteria were met concurrently in 82.6% of C-MLB patients, in 80.0% of MS-MLB patients, and in 81.4% of all 43 patients. For each dosimetric parameter, t-test of these 2 groups showed p > 0.05. Although the geometric design of C-MLB is different from that of MS-MLB, both applicators have the ability to shape the dose distribution and to provide good target coverage, while limiting the dose to skin and rib. No significant difference was observed between the 2 patient groups in terms of target dose coverage and dose to organs at risk.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA. Electronic address: fuw@upmc.edu.
authors.forename: Weihua
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors.forename: Alex S J
authors.initials: AS
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Mehta
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors.forename: Pietro
authors.initials: P
authors.lastname: Pucci
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors.forename: M Saiful
authors.initials: MS
authors.lastname: Huq
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D001943:Breast Neoplasms / Q000532:radiotherapy*; D057785:Catheters; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D059351:Organ Sparing Treatments / Q000295:instrumentation; D058958:Organs at Risk / Q000528:radiation effects; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012272:Ribs / Q000528:radiation effects*; D012867:Skin / Q000528:radiation effects*; D016896:Treatment Outcome
keywords: Accelerated partial-breast irradiation; Balloon brachytherapy; Breast cancer; Contura MLB; MammoSite MLB