title: Cardioprotective effect of fimasartan, a new angiotensin receptor blocker, in a porcine model of acute myocardial infarction.
abstract: Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Doo Sun
authors.identifier: 0000-0003-4162-7902
authors.initials: DS
authors.lastname: Sim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Myung Ho
authors.identifier: 0000-0003-4173-1494
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Ho Chun
authors.identifier: 0000-0002-6407-8160
authors.initials: HC
authors.lastname: Song
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Jahae
authors.identifier: 0000-0003-4077-7722
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Ari
authors.identifier: 0000-0001-9327-9810
authors.initials: A
authors.lastname: Chong
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hee Seung
authors.initials: HS
authors.lastname: Bom
authors.affiliation: Department of Cardiothoracic Surgery, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: In Seok
authors.identifier: 0000-0002-2249-0667
authors.initials: IS
authors.lastname: Jeong
authors.affiliation: Department of Cardiothoracic Surgery, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Sang Gi
authors.identifier: 0000-0001-9394-4980
authors.initials: SG
authors.lastname: Oh
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Dae Sung
authors.identifier: 0000-0002-9948-7546
authors.initials: DS
authors.lastname: Park
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jung Ha
authors.identifier: 0000-0003-3334-3432
authors.initials: JH
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Kyung Seob
authors.identifier: 0000-0002-9117-887X
authors.initials: KS
authors.lastname: Lim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Shi Hyun
authors.identifier: 0000-0001-8376-5946
authors.initials: SH
authors.lastname: Ryu
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Hyun Kuk
authors.identifier: 0000-0002-4554-041X
authors.initials: HK
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Sung Soo
authors.identifier: 0000-0002-5190-227X
authors.initials: SS
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Su Young
authors.identifier: 0000-0001-5843-0802
authors.initials: SY
authors.lastname: Jang
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jae Yeong
authors.identifier: 0000-0002-9393-2821
authors.initials: JY
authors.lastname: Cho
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Hae Chang
authors.identifier: 0000-0002-1273-3864
authors.initials: HC
authors.lastname: Jeong
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Ki Hong
authors.identifier: 0000-0002-9938-3464
authors.initials: KH
authors.lastname: Lee
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Nam Sik
authors.identifier: 0000-0001-9112-150X
authors.initials: NS
authors.lastname: Yoon
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Kye Hun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Young Joon
authors.identifier: 0000-0003-0192-8161
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Hyung Wook
authors.identifier: 0000-0002-9630-0467
authors.initials: HW
authors.lastname: Park
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Ju Han
authors.initials: JH
authors.lastname: Kim
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jeong Gwan
authors.initials: JG
authors.lastname: Cho
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jong Chun
authors.identifier: 0000-0002-3168-2054
authors.initials: JC
authors.lastname: Park
authors.affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea.
authors.forename: Jung Chaee
authors.initials: JC
authors.lastname: Kang
mesh_terms: D019797:3-Iodobenzylguanidine; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D056988:Anterior Wall Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004452:Echocardiography; D019788:Fluorodeoxyglucose F18; D020913:Perindopril / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D011743:Pyrimidines / Q000627:therapeutic use*; D011897:Random Allocation; D013552:Swine; D013777:Tetrazoles / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon; D000068756:Valsartan / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001713:Biphenyl Compounds; D002316:Cardiotonic Agents; D011743:Pyrimidines; D013777:Tetrazoles; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine; D000068756:Valsartan; C558933:fimasartan; D020913:Perindopril
keywords: Angiotensin Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Myocardial Infarction