title: Histone deacetylase inhibitor for NUT midline carcinoma.
abstract: NUT Midline carcinoma (NMC) is a rare and invariably fatal poorly differentiated carcinoma characterized by chromosomal rearrangement involving the nuclear protein of the testis (NUT) gene. Current approaches do not provide durable response. We report a case of widely metastatic NMC in a 17-year-old female who, following an initial response to combination chemotherapy developed rapid disease progression. Treatment with vorinostat, a histone deacetylase inhibitor (HDACi) resulted in an objective response, yet she died in less than one year from initial diagnosis. This report shows a potentially promising activity of HDACi in the treatment of NMC that needs further exploration.
authors.affiliation: Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, Texas; Department of Pediatrics, National Cancer Institute, Cairo University, Cairo, Egypt.
authors.forename: Ossama M
authors.initials: OM
authors.lastname: Maher
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Christensen
authors.forename: Sireesha
authors.initials: S
authors.lastname: Yedururi
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
authors.forename: Nidale
authors.initials: N
authors.lastname: Tarek
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage*; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage*; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D009362:Neoplasm Metastasis; D016066:Pleural Effusion, Malignant / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D000077337:Vorinostat
chemical_list: D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D000077337:Vorinostat
keywords: NUT midline carcinoma; histone deacetylase inhibitor