title: Design and synthesis of novel 19F-amino acid: a promising 19F NMR label for peptide studies.
abstract: Novel aliphatic (19)F-substituted amino acid was designed as a (19)F NMR label for peptide studies. The synthesis was performed in 11 steps and 9% overall yield from a commercially available starting material. The key transformation was a decarboxylative fluorination of an aliphatic carboxylic acid with XeF2 in C6F6.
authors.affiliation: Department of Chemistry, Taras Shevchenko National University of Kyiv , Volodymyrska 64, Kyiv 01601, Ukraine.
authors.forename: Dmytro
authors.initials: D
authors.lastname: Bandak
authors.forename: Oleg
authors.initials: O
authors.lastname: Babii
authors.forename: Roman
authors.initials: R
authors.lastname: Vasiuta
authors.forename: Igor V
authors.initials: IV
authors.lastname: Komarov
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk
mesh_terms: D024322:Amino Acids, Aromatic / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014978:Xenon / Q000737:chemistry*
chemical_list: D024322:Amino Acids, Aromatic; D002264:Carboxylic Acids; D010455:Peptides; D005461:Fluorine; D014978:Xenon; C048007:xenon fluoride; D005459:Fluorides