title: [The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of Guerin's carcinoma growth under the low-level irradiation conditions].
abstract: Mitochondrial NADH-dehydrogenase, succinate dehydrogenase and cytochrome oxidase activities of peripheral blood leukocytes of rats with the grafted Guerin's carcinoma were studied in the dynamics of oncogenesis under the conditions of the preliminary low-level irradiation. Tumor growth was accompanied by a decrease in NADH-dehydrogenase activity, an increase of succinate dehydrogenase activity. Cytochrome oxidase activity of leucocytes remained at the control level up to the terminal stages of tumor growth. Preliminary low-level irradiation of the tumor bearing animals caused a tendency to the decrease of enzymatic activities studied. This tendency was observed from the initial stages of oncogenesis.
authors.affiliation: Yurii Fedkovych Chernovtsi National University.
authors.forename: M M
authors.initials: MM
authors.lastname: Marchenko
authors.affiliation: Yurii Fedkovych Chernovtsi National University.
authors.forename: O N
authors.initials: ON
authors.lastname: Voloshchuk
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D002277:Carcinoma / Q000201:enzymology* / Q000473:pathology; D003576:Electron Transport Complex IV / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D009245:NADH Dehydrogenase / Q000378:metabolism; D009368:Neoplasm Transplantation; D011829:Radiation Dosage; D051381:Rats; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014916:Whole-Body Irradiation; D014965:X-Rays
chemical_list: D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV
keywords: Guerin's carcinoma; NADH-dehydrogenase activity; cytochrome oxidase activity; leukocytes; succinate dehydrogenase activity