title: The Use of Registries to Improve Cancer Treatment: A National Database for Patients Treated with Interleukin-2 (IL-2).
abstract: Registries evaluating un-randomized patients have provided valuable information with respect to a therapy's utility, treatment practices, and evolution over time. While immunotherapy for cancer has been around for more than three decades, data collection in the form of a registry has not been undertaken. The authors believe that establishing a registry to study HD IL-2 immunotherapy, which has been the only systemic therapy producing long term unmaintained remissions for advanced kidney cancer and melanoma for over 20 years, will be an important resource in understanding the impact of immunotherapy with HD IL-2 in a rapidly changing therapeutic environment. Optimizing administration and improving selection of appropriate patients likely to benefit from HD IL-2 immunotherapy are two of many benefits to be derived from this endeavor.
authors.affiliation: Department of Surgery, Rutgers Cancer Center Institute of New Jersey, 195 Little Albany Street, Room 2007, New Brunswick, NJ 08901, USA. howard.kaufman@rutgers.edu.
authors.forename: Howard L
authors.initials: HL
authors.lastname: Kaufman
authors.affiliation: Department of Medicine, University of Southern California, 1441 Eastlake Avenue, Suite 3455, Los Angeles, CA 90033, USA. mike.wong@med.usc.edu.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Wong
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA. gdaniels@ucsd.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Daniels
authors.affiliation: Beth Israel Hospital Deaconess Medical Center, Masco Building, 375 Longwood Avenue, Boston, MA 02215, USA. dmcdermo@bidmc.harvard.edu.
authors.forename: David F
authors.initials: DF
authors.lastname: McDermott
authors.affiliation: Prometheus Laboratories Inc., 9410 Carroll Park Drive, San Diego, CA 92121, USA. sandra.aung@prometheuslabs.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Aung
authors.affiliation: Prometheus Laboratories Inc., 9410 Carroll Park Drive, San Diego, CA 92121, USA. jlowder@prometheuslabs.com.
authors.forename: James N
authors.initials: JN
authors.lastname: Lowder
authors.affiliation: Duke University Medical Center, 10 Bryan Searle Drive, Mudd Building, Rm 437, Durham, NC 27710, USA. Michael.morse@duke.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Morse