title: In situ intramolecular catalytic 1,2-addition of allenoates to cyclic ketones towards polycyclic allenoates.
abstract: Sequential deprotonation, isomerization of 3-alkynoates and subsequent 1,2-addition led to bicyclic allenoate in the presence of a catalytic amount of Cs2CO3. Cyclization proceeds in a totally stereoselective manner in the case of the two-carbon linker chain. A one-pot reaction starting from alkynyl ketones afforded tricyclic fused ring systems with good yields.
authors.affiliation: Université de Strasbourg, Institut de Chimie, UMR Unistra-CNRS 7177, Laboratoire de Chimie Organique Synthétique, 1 rue Blaise Pascal, BP296/R8, 67008-Strasbourg, France. lmiesch@unistra.fr.
authors.forename: Clément F
authors.initials: CF
authors.lastname: Heinrich
authors.forename: Michel
authors.initials: M
authors.lastname: Miesch
authors.forename: Laurence
authors.initials: L
authors.lastname: Miesch