title: Can adenocarcinoma in situ of the uterine cervix be treated safely by conisation in combination with endocervical curettage?
abstract: OBJECTIVE
  To evaluate the prognostic value of endocervical curettage (ECC) after conisation in patients treated for adenocarcinoma in situ (AIS) of the uterine cervix.
  
  
  METHODS
  Patients with AIS diagnosed between 1990 and 2010 and with a minimum of 1.5 years of follow-up were retrospectively identified using computerised clinical files.
  
  
  RESULTS
  The authors identified 195 patients (median age 32 years) with a median follow-up of 6.4 years. ECC was performed in 165 patients. In 144 (87%) the initial ECC was normal. In 129 no recurrence was observed during follow-up (90%). A positive ECC was observed in 21. Thirteen patients had hysterectomies; six hysterectomies were normal. Eight patients treated conservatively developed no recurrent disease. Two patients with a positive ECC did not have a hysterectomy and developed recurrent disease. In patients with affected margins, 17% developed recurrent disease.
  
  
  CONCLUSIONS
  ECC performed during initial conisation is a prognostic tool for the treatment ofAIS. Close follow-up is recommended in patients treated conservatively.
authors.affiliation: Department of Gynecology,  University  Hospital of Aarhus, Denmark. Berit.Booth@auh.rm.dk
authors.forename: B B
authors.initials: BB
authors.lastname: Booth
authors.forename: L K
authors.initials: LK
authors.lastname: Petersen
mesh_terms: D065311:Adenocarcinoma in Situ / Q000601:surgery*; D000328:Adult; D000368:Aged; D019092:Conization / Q000379:methods*; D003475:Curettage / Q000379:methods*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000601:surgery*