title: The contribution of non-human primate models to the development of human vaccines.
abstract: The non-human primates (NHPs) model in biomedical research has contributed to the study of human infectious, autoimmune, oncogenic, and neurological diseases. This review focuses on the importance of NHP models in vaccine development for tuberculosis, pertussis, Dengue, group A streptococcus (Streptococcus pyogenes) infection, HIV infection, and certain diseases in the elderly (influenza, for example). From understanding disease pathogenesis and mechanisms of protection, to assessing vaccine safety and efficacy, we discuss selected cases where the importance of the use of NHP models is highlighted.
authors.affiliation: School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Tania
authors.initials: T
authors.lastname: Rivera-Hernandez
authors.affiliation: Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.
authors.forename: Diane G
authors.initials: DG
authors.lastname: Carnathan
authors.affiliation: School of Pharmacy, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Moyle
authors.affiliation: School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, and School of Pharmacy, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
authors.affiliation: School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: West
authors.affiliation: School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Young
authors.affiliation: Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
authors.affiliation: School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Walker
mesh_terms: D000368:Aged; D000818:Animals; D003140:Communicable Disease Control / Q000379:methods*; D006801:Humans; D023421:Models, Animal; D011323:Primates; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines