title: [The effect of sodium fluoroacetate and metformin on the antitumor activity of cyclophosphamide on the autochthonous mice sarcoma model].
abstract: Previously it was found that sodium fluoroacetate (SF) inhibited the growth of the Ehrlich cancer by means of monotherapy and enhanced the antitumor effect of cyclophosphamide (CP) in experiments with autochthonous subcutaneous tumors induced by benzo (a) pyrene. In this study a comparison of the antitumor activity of SF and metformin showed that both substances did not have significant effect in monotherapy but enhanced the effect of CP, increasing the percentage of tumors with the same or reduced volume. Besides, SF, unlike metformin increased the average duration of effect. The data obtained promoted further study of the mechanism of the antitumor effect of SF and the search effective combination with already known antitumor drugs.
authors.forename: I V
authors.initials: IV
authors.lastname: Anikin
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharov
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: N G
authors.initials: NG
authors.lastname: Voĭshenko
authors.forename: G B
authors.initials: GB
authors.lastname: Pliss
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004357:Drug Synergism; D005463:Fluoroacetates / Q000494:pharmacology*; D008687:Metformin / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D005463:Fluoroacetates; D003520:Cyclophosphamide; D008687:Metformin; C014815:fluoroacetic acid