title: Possible role of GABA-B receptor modulation in MPTP induced Parkinson's disease in rats.
abstract: Accumulating evidence strongly suggests that gamma amino butyric acid (GABA) receptors play a crucial role in the pathogenesis of Parkinson's disease (PD). Therefore, the present study was designed to investigate the role of GABA-B receptor modulation in experimental models of MPTP-induced PD. MPTP was administered repeatedly on 1st, 7th and 14th day intranigrally for the induction of PD in Male Wistar rats. Baclofen (10 and 20mg/kg) and GABA-B antagonist CGP35348 (10mg/kg) were given after induction of PD for 14 days. Different behavioural tasks were performed during 1st, 14th, 21st, 28th days after MPTP injection and biochemical parameters were estimated on day 28th. Central administration of MPTP showed significant impairment of motor behaviour and marked increase of oxidative damage LPO and GSH in striatum and cortex. Pro-inflammatory cytokines like TNF-α and IL-β were significantly increased in striatum region of MPTP treated rats. However, post treatment with baclofen significantly improved the motor abnormalities and attenuated the oxidative damage and neuro-inflammation in MPTP treated rats. CGP35348, GABA-B receptor antagonist, reversed the protective effect of baclofen GABA-B receptor play role in the neuroprotection. The present study concluded that baclofen produce beneficial effect against MPTP induced PD like symptoms rats through GABAergic mechanism.
authors.affiliation: Department of Pharmacology, Indo Soviet Friendship (ISF) College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Ravi Kant
authors.initials: RK
authors.lastname: Tyagi
authors.affiliation: Department of Pharmacology, Indo Soviet Friendship (ISF) College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Bisht
authors.affiliation: Department of Pharmacology, Indo Soviet Friendship (ISF) College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Jatin
authors.initials: J
authors.lastname: Pant
authors.affiliation: Department of Pharmacology, Indo Soviet Friendship (ISF) College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Puneet
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: Abu Bakar Abdul
authors.initials: AB
authors.lastname: Majeed
authors.affiliation: Department of Pharmacology, Indo Soviet Friendship (ISF) College of Pharmacy, Moga 142001, Punjab, India; Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Brain Degeneration and Therapeutics Group, Brain and Neuroscience Communities of Research, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia. Electronic address: atishprakash@gmail.com.
authors.forename: Atish
authors.initials: A
authors.lastname: Prakash
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D058786:GABA-B Receptor Agonists / Q000494:pharmacology; D058788:GABA-B Receptor Antagonists / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000378:metabolism*; D045442:Rotarod Performance Test
chemical_list: D016207:Cytokines; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; D018080:Receptors, GABA-B; C066430:CGP 35348; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D001418:Baclofen
keywords: Antioxidant; CGP35348; GABA-B; MPTP; Neuroinflammation