title: Quality of life in multiple myeloma: clinical validation of the Mexican-Spanish version of the QLQ-MY20 instrument.
abstract: Health-related quality of life (HRQL) has become an important outcome measurement in hematology. Our aim was to validate the quality of life questionnaire (QLQ)-MY20 instrument in patients with multiple myeloma (MM) in Mexico. The Mexican-Spanish versions of the QLQ-C30 and QLQ-MY20 instruments were applied to patients with MM at a cancer referral centre. Reliability and validity tests were performed. Test-retest was carried out in selected patients. Ninety-eight patients with MM were included in this study. Questionnaire compliance rates were high, and the instrument was well accepted; internal consistency tests demonstrated good convergent and divergent validity. Cronbach's α coefficients of seven of nine multi-item scales of the QLQ-C30 and of all three multi-item scales of the QLQ-MY20 instruments were >0.7 (range, 0.36-0.89). The scales of the QLQ-C30 and QLQ-MY20 instruments distinguished among clinically distinct groups of patients; 9 of 15 scales of the QLQ-C30 and all 4 scales of the QLQ-MY20 presented responsiveness after change over time. The Mexican-Spanish version of the QLQ-MY20 questionnaire is reliable and valid for the assessment of HRQL in patients with MM and can be used in clinical trials in the Mexican community.
authors.affiliation: Departamento de Hematología, Instituto Nacional de Cancerología (INCan), San Fernando 22, 14080, Mexico City, Mexico.
authors.forename: José Ramiro
authors.initials: JR
authors.lastname: Espinoza-Zamora
authors.forename: César Miguel
authors.initials: CM
authors.lastname: Portilla-Espinosa
authors.forename: Juan Rafael
authors.initials: JR
authors.lastname: Labardini-Méndez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cervera
authors.forename: Ruben
authors.initials: R
authors.lastname: Niesvisky
authors.forename: Luis F
authors.initials: LF
authors.lastname: Oñate-Ocaña
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards*