title: [Apolipoprotein A-I and B in laboratory diagnostics of dyslipidemia--what benefits do we gain compared with cholesterol measurements?].
abstract: Laboratory diagnostics of dyslipidemia has been based on serum total cholesterol, HDL- cholesterol, triglycerides, and calculated or direct LDL-cholesterol measurements. Apolipoprotein A-I (apoA-I) is the main protein in HDL particles, and apoB is the main protein in all other atherogenic lipoprotein particles. An increased number of apoB-containing lipoproteins with normal total and LDL-cholesterol is a common feature associated with obesity, metabolic syndrome, or type 2 diabetes. If the risk assessment of cardiovascular disease in these cardiometabolic disturbances is primarily based on LDL-cholesterol levels, the actual risk may be underestimated. Instead of cholesterol measurements, ApoA-Iand apoB measurements could produce more specific information on dyslipidemia.
authors.affiliation: THL, Kansantautien ehkäisyn osato, tautiriskiyksikkö.
authors.forename: Jaana
authors.initials: J
authors.lastname: Leiviskä
authors.forename: Jouko
authors.initials: J
authors.lastname: Sundvall
authors.forename: Matti
authors.initials: M
authors.lastname: Jauhiainen
authors.forename: Tiina
authors.initials: T
authors.lastname: Laatikainen
mesh_terms: D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D050171:Dyslipidemias / Q000097:blood*; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood; D009765:Obesity / Q000097:blood; D018570:Risk Assessment
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D002784:Cholesterol