title: Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
abstract: Whether or not CD4(+) T-cells express low affinity receptor FcγRIIIa (CD16a) in disease pathology has not been examined in great detail. In this study, we show that a subset of activated CD4(+) T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune complexes (ICs) in human CD4(+) T-cells produced co-stimulatory signal like CD28 that triggered IFN-γ production. The induced expression of FcγRIIIa on CD4(+) helper T-cells is an important finding since these receptors via ITAM contribute to intracellular signaling. The induced expression of FcγRIIIa on CD4(+) T helper cells and their ability to co-stimulate T-cell activation are important and novel findings that may reveal new pathways to regulate adaptive immune responses during inflammation and in autoimmunity.
authors.affiliation: From the Division of Adult and Pediatric Rheumatology and; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63104. Electronic address: chauhana@slu.edu.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Chauhan
authors.affiliation: From the Division of Adult and Pediatric Rheumatology and.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: From the Division of Adult and Pediatric Rheumatology and.
authors.forename: Terry L
authors.initials: TL
authors.lastname: Moore
authors.affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: DiPaolo
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018106:CD28 Antigens / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology* / Q000378:metabolism; D019169:Jurkat Cells; D008213:Lymphocyte Activation; D008297:Male; D017452:Receptors, IgG / Q000096:biosynthesis / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000473:pathology
chemical_list: D018106:CD28 Antigens; C496124:FCGR3A protein, human; C573415:IFNG protein, human; D017452:Receptors, IgG; D007371:Interferon-gamma
keywords: T cell; autoimmune disease; autoimmunity; complement; immune complexes; inflammation; interferon