title: The effects of serum apolipoprotein E genetic variants and concentration on serum lipid parameters in haemodialysis patients.
abstract: OBJECTIVE
  Many epidemiological studies demonstrate that the apolipoprotein E gene (ApoE) is an important candidate gene for playing key roles in the development of haemodialysis (HD). The purpose of this study is to evaluate the effects of ApoE genetic variants and concentration on serum lipid parameters in HD.
  
  
  METHODS
  A total of 288 HD patients and 292 healthy controls were enrolled in this case-control study. The genotypes of ApoE genetic variants were investigated through the created restriction site-polymerase chain reaction and DNA-sequencing methods.
  
  
  RESULTS
  Our data indicated that the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I (ApoA-I), ApoB, ApoE, lipoprotein (a) (Lp(a)) of mutant genotypes in ApoE c.61G > A and c.761T > A genetic variants were different from those subjects with wild genotype in HD patients and healthy controls.
  
  
  CONCLUSIONS
  These preliminary results from this study suggest that the ApoE genetic variants and concentration could affect the serum lipid parameters in HD and could be risk factors for evaluating HD.
authors.affiliation: Department of Blood Purification, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Institute of Nephrology, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.forename: Yingjin
authors.initials: Y
authors.lastname: Qiao
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Lu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhangsuo
authors.initials: Z
authors.lastname: Liu
mesh_terms: D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D008055:Lipids
keywords: ApoE gene; genetic variants; haemodialysis; risk factors; serum lipid