title: Adiponectin and visfatin may serve as diagnosis markers for metabolic syndrome in Uygur population.
abstract: OBJECTIVE
  This study is to determine if two adipocytokines, adiponectin and visfatin, can be used as diagnosis markers for metabolic syndrome (MS) in Uygur population.
  
  
  METHODS
  Sixty-two MS patients and 41 control individuals with normal body weights were enrolled in this study. Abdominal subcutaneous and omental adipose tissues were collected for determination of biochemical indices. The adipokines serum levels were determined by enzyme-linked immunosorbent assay (ELISA). Blood were collected from the MS patients and the control individuals and extracted proteins and RNAs subjected to western blot analysis and real-time PCR to determine adiponectin and visfatin expression, respectively.
  
  
  RESULTS
  ELISA indicated that the serum adiponectin in the MS group was decreased (0.59 ± 0.21 versus 0.49 ± 0.18) in comparison with the control group (P < 0.05). But the serum visfatin in the MS group were increased (1.07 ± 0.41 versus 1.25 ± 0.32) when compared with the control group (P < 0.05). The western blot revealed decreased adiponectin and increased visfatin expression in the MS patients when compared with the normal controls. Further real-time RT-PCR analysis showed that the adiponectin and visfatin expression are altered via a transcriptional mechanism.
  
  
  CONCLUSIONS
  Adiponectin and visfatin might be used as diagnosis markers of MS in Uygur population.
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chang
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Endoscopic Branch, Xinjiang Uygur Autonomous Regional People's Hospital NO. 91 Tian Chi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Kelim
authors.initials: K
authors.lastname: Abudureyimu
authors.affiliation: Endoscopic Branch, Xinjiang Uygur Autonomous Regional People's Hospital NO. 91 Tian Chi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Nuerbiye
authors.initials: N
authors.lastname: Nuermaimaiti
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Xian
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Yiliyasi
authors.initials: Y
authors.lastname: Aisa
authors.affiliation: Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University NO. 393 Xin Yi Road, Urumqi, Xinjiang 830000, P. R. China.
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Guan
keywords: Metabolic syndrome; adipocytokine; adiponectin; visfatin