title: Increased serum concentrations of adiponectin in canine hypothyroidism.
abstract: Serum concentrations of adiponectin were compared between sex-matched hypothyroid (n = 18) and euthyroid (n = 18) client-owned dogs with comparable ages and body condition scores (BCS). Concentrations of adiponectin (mean; 95% confidence interval) were significantly (P < 0.01) higher in hypothyroid (17.2 µg/mL; 12.1-20.5 µg/mL) than healthy (8.0 µg/mL; 5.6-11.4 µg/mL) dogs following adjustment for potential confounders (BCS, age and sex). Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine (P <0.05) and positively correlated with concentrations of cholesterol (r = 0.6, P <0.01) in hypothyroid dogs. In conclusion, this study demonstrated increased serum concentrations of adiponectin in dogs with hypothyroidism. Suggestive of the presence of resistance to adiponectin that could have contributed to development of hyperlipidemia and insulin resistance in these dogs or alternatively, could be a consequence of these metabolic alterations.
authors.affiliation: Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot, 76100, Israel. Electronic address: mmtovi@gmail.com.
authors.forename: Michal
authors.initials: M
authors.lastname: Mazaki-Tovi
authors.affiliation: The Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Abood
authors.affiliation: The American Medical Laboratories, Ramot Yam 7, Herzliya Pituah 460100, Israel; Comparative Pathology Graduate Group, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Kol
authors.affiliation: The American Medical Laboratories, Ramot Yam 7, Herzliya Pituah 460100, Israel.
authors.forename: Amnon
authors.initials: A
authors.lastname: Farkas
authors.affiliation: The Department for Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA; Veterinary Consulting, DeWitt, MI, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schenck
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004283:Dog Diseases / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D013974:Thyroxine / Q000097:blood
chemical_list: D052242:Adiponectin; D002784:Cholesterol; D013974:Thyroxine
keywords: Adiponectin; Canine; Hyperlipidaemia; Hypothyroidism; Obesity