title: Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.
abstract: objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.
  
  
  METHODS
  PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
  
  
  RESULTS
  PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
  
  
  CONCLUSIONS
  PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Oncology, Leiyang People's Hospital Leiyang City, Hunan Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lei
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Central Laboratory of Shantou University Shantou City, Guangdong Province, China.
authors.forename: Yaowen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Sheng
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Peixin
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D020929:Mitogen-Activated Protein Kinase Kinases; C409022:PDZ-binding kinase
keywords: CINI; Cervical carcinoma; PDZ-binding kinase; T-LAK; quantitative analysis