title: MiRNA inhibition in tissue engineering and regenerative medicine.
abstract: MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.
authors.affiliation: Interdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Kelsey R
authors.initials: KR
authors.lastname: Beavers
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Nelson
authors.affiliation: Interdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: craig.duvall@vanderbilt.edu.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Duvall
mesh_terms: D001842:Bone and Bones / Q000502:physiology; D002921:Cicatrix / Q000378:metabolism; D005822:Genetic Vectors; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D035683:MicroRNAs / Q000037:antagonists & inhibitors*; D018482:Muscle, Skeletal / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
keywords: Anti-miR; MiRNA; MiRNA inhibition; Regenerative medicine; Tissue engineering