title: Prepubertal unilateral gynecomastia: report of 2 cases.
abstract: Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.
authors.affiliation: Diyarbakır Children State Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey. E-mail: dr_huseyin@hotmail.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Demirbilek
authors.forename: Gökhan
authors.initials: G
authors.lastname: Bacak
authors.forename: Rıza Taner
authors.initials: RT
authors.lastname: Baran
authors.forename: Yahya
authors.initials: Y
authors.lastname: Avcı
authors.forename: Ahmet
authors.initials: A
authors.lastname: Baran
authors.forename: Ayşenur
authors.initials: A
authors.lastname: Keleş
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Özbek
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Alanay
authors.forename: Khalid
authors.initials: K
authors.lastname: Hussain
mesh_terms: D002648:Child; D006177:Gynecomastia / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D011627:Puberty