title: Impact of increasing sample volume from 4 ml to 8 ml on bacterial detection rates in apheresis platelets: a meta-analysis.
abstract: Some blood centres have increased sample volume of in-process cultures to improve detection of bacterial contamination when screening apheresis platelet units. We performed a meta-analysis to evaluate extant published North American data comparing apheresis platelet bacterial contamination rates from 4 ml and 8 ml sample volume. Pooled results indicate an 8 ml sample volume yields higher true-positive rates than 4 ml resulting in a significant increase in the detection rate and interdiction of contaminated units, which should contribute to reduced risk of adverse transfusion outcomes.
authors.affiliation: Blood Systems Research Institute, San Francisco, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bruhn
authors.forename: B
authors.initials: B
authors.lastname: Custer
authors.forename: S
authors.initials: S
authors.lastname: Vanderpool
authors.forename: M
authors.initials: M
authors.lastname: Townsend
authors.forename: H
authors.initials: H
authors.lastname: Kamel
authors.forename: P
authors.initials: P
authors.lastname: Tomasulo
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D001792:Blood Platelets / Q000382:microbiology*; D058731:Blood Safety / Q000379:methods*; D006801:Humans; D018401:Sample Size
keywords: bacterial contamination; bacterial detection; platelets