title: Pathogenicity of H5N8 virus in chickens from Korea in 2014.
abstract: In 2014, two genetically distinct H5N8 highly pathogenic avian influenza (HPAI) viruses were isolated from poultry and wild birds in Korea. The intravenous pathogenicity indices for the two representative viruses were both 3.0. Mortality of chickens intranasally inoculated with the two H5N8 viruses was 100% with a mean death times of 2.5 and 4.5 days. Mortality rates of the contact groups for the two H5N8 viruses were 33.3% and 66.6%. Our study showed that transmissibility of the novel H5N8 viruses was different from that of previously identified H5N1 HPAI viruses, possibly due to genetic changes.
authors.affiliation: Division of Avian Diseases, Animal and Plant Quarantine Agency, Anyang 430-757, Korea.
authors.forename: Byung-Min
authors.initials: BM
authors.lastname: Song
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Lee
authors.forename: Jipseol
authors.initials: J
authors.lastname: Jung
authors.forename: Yeojin
authors.initials: Y
authors.lastname: Kang
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Lee
authors.forename: Youn-Jeong
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary; D009980:Influenza A virus / Q000472:pathogenicity* / Q000502:physiology*; D005585:Influenza in Birds / Q000401:mortality* / Q000635:transmission / Q000821:virology; D011201:Poultry Diseases / Q000401:mortality* / Q000635:transmission / Q000821:virology; D056910:Republic of Korea / Q000453:epidemiology; D014774:Virulence
keywords: H5N8; chicken; highly pathogenic avian influenza; pathogenicity