title: Effects of oxymetazoline on nasal flow and maximum aerobic exercise performance in patients with inferior turbinate hypertrophy.
abstract: OBJECTIVE
  To determine the effect of topical intranasal oxymetazoline on nasal resistance and aerobic exercise performance in patients with nasal congestion caused by inferior turbinate hypertrophy.
  
  
  METHODS
  Individual randomized controlled trial.
  
  
  METHODS
  Eight patients with inferior turbinate hypertrophy performed a set of exercise tests to exhaustion 1 week apart. They were given oxymetazoline or a placebo before each of the two test sessions according to a random pattern. Changes in nasal airflow were measured as peak nasal flow and ventilatory efficiency parameters, ventilatory equivalents, end-expiratory pressure, oxygen consumption, cardiac efficiency, rate of perceived exertion, and maximal and submaximal mechanical power.
  
  
  RESULTS
  Ten minutes after use of the drug or placebo, improvements in maximum nasal airflow were seen in the oxymetazoline group (P < 0.05). However, exercise tests showed improvements in both groups (P < 0.05). After exertion, there was no difference between the two groups in maximum nasal airflow (P > 0.05). There were no differences between groups in oxygen consumption, rate of perceived exertion, respiratory exchange ratio, ventilation, or ventilatory equivalents for oxygen.
  
  
  CONCLUSIONS
  Oxymetazoline increased nasal airflow in patients with turbinate hypertrophy, but this change did not translate into gains in physical exercise parameters or perceived exertion.
  
  
  METHODS
  1b.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario San Cecilio de Granada.|Servicio de Otorrinolaringología, Hospital La Inmaculada, Huércal-Overa, Almería, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Hervás
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario San Cecilio de Granada.
authors.forename: Juan
authors.initials: J
authors.lastname: García-Valdecasas Bernal
authors.affiliation: Unidad de Gestión Clínica Medicina Preventiva, Vigilancia y Promoción de la Salud, Hospital Universitario San Cecilio de Granada.|Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Central de Asturias, Oviedo.
authors.forename: María
authors.initials: M
authors.lastname: Fernández-Prada
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario San Cecilio de Granada.|Servicio de Otorrinolaringología, Hospital Costa del Sol, Marbella.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Palomeque-Vera
authors.affiliation: Facultad de Ciencias de la Actividad Física y el Deporte de la Universidad de Granada, Granada.
authors.forename: Amador
authors.initials: A
authors.lastname: García-Ramos
authors.affiliation: Facultad de Ciencias de la Actividad Física y el Deporte de la Universidad de Granada, Granada.
authors.forename: Belén F
authors.initials: BF
authors.lastname: Fernández-Castanys
mesh_terms: D000281:Administration, Intranasal; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D014663:Nasal Decongestants / Q000494:pharmacology / Q000627:therapeutic use*; D009666:Nose / Q000503:physiopathology; D010109:Oxymetazoline / Q000494:pharmacology / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects*; D014420:Turbinates / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D014663:Nasal Decongestants; D010109:Oxymetazoline
keywords: Turbinate; oxymetazoline; physical exercise; rhinitis