title: Monitoring the evolution of crystallization processes by in-situ solid-state NMR spectroscopy.
abstract: Crystallization processes play a crucial role in many aspects of biological and physical sciences. Progress in deepening our fundamental understanding of such processes relies, to a large extent, on the development and application of new experimental strategies that allow direct in-situ monitoring of the process. In this paper, we give an overview of an in-situ solid-state NMR strategy that we have developed in recent years for monitoring the time-evolution of different polymorphic forms (or other solid forms) that arise as the function of time during crystallization from solution. The background to the strategy is described and several examples of the application of the technique are highlighted, focusing on both the evolution of different polymorphs during crystallization and the discovery of new polymorphs.
authors.affiliation: School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales, UK. Electronic address: HarrisKDM@cardiff.ac.uk.
authors.forename: Kenneth D M
authors.initials: KD
authors.lastname: Harris
authors.affiliation: School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales, UK.
authors.forename: Colan E
authors.initials: CE
authors.lastname: Hughes
authors.affiliation: School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales, UK.
authors.forename: P Andrew
authors.initials: PA
authors.lastname: Williams
mesh_terms: D003460:Crystallization / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013997:Time Factors
keywords: Crystallization processes; In-situ NMR; NMR crystallography; Polymorphism