title: A successful case of Cushing's disease pregnancy treated with ketoconazole.
abstract: OBJECTIVE
  The association of pregnancy and Cushing's disease (CD) is rare. Treatment of Cushing's syndrome (CS) is imperative to reduce maternal and fetal morbidity. Ketoconazole is a widely used drug for CS control when the woman is not pregnant but concerns about its teratogenicity and embryotoxicity restricted its use during pregnancy.
  
  
  RESULTS
  We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy. She delivered a normal female baby.
  
  
  CONCLUSIONS
  It is supposed that even with treatment the relatively hypercortisolemic mother could protect her child from the embryotoxicity of ketoconazole as proved in rat fetuses and we suggest that ketoconazole could be an emergency pharmacological therapeutic option for CS management during pregnancy.
authors.affiliation: Post Graduate Program in Endocrinology, Metabolism and Nutrition, Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil .
authors.forename: Fabíola
authors.initials: F
authors.lastname: Costenaro
authors.forename: Ticiana C
authors.initials: TC
authors.lastname: Rodrigues
authors.forename: Paula B
authors.initials: PB
authors.lastname: de Lima
authors.forename: Juliana
authors.initials: J
authors.lastname: Ruszczyk
authors.forename: Guilherme
authors.initials: G
authors.lastname: Rollin
authors.forename: Mauro A
authors.initials: MA
authors.lastname: Czepielewski
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D047748:Pituitary ACTH Hypersecretion / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D016896:Treatment Outcome
chemical_list: D007654:Ketoconazole
keywords: Cushing’s disease; Cushing’s syndrome; ketoconazole; pregnancy