title: Fibroblast growth factor-21 concentration in serum and synovial fluid is associated with radiographic bone loss of knee osteoarthritis.
abstract: We aimed to evaluate whether FGF-21 concentration in serum and synovial fluid (SF) is associated with radiographic bone loss of knee osteoarthritis (OA). A total of 186 OA patients and 108 controls were recruited. The radiographic bone loss of knee OA was assessed by the Ahlbäck grading scale. FGF-21 concentration in serum and SF was measured by enzyme-linked immunosorbent assay (ELISA). We demonstrated that OA patients had significantly higher serum FGF-21 concentration compared with controls (204.30 [range 158.25-279.16] ng/L vs. 130.72 [range 94.93-218.03] ng/L, p < 0.01). FGF-21 concentration in serum was well correlated with that in paired SF samples (r = 0.668, p < 0.001). In OA patients, those with a higher Ahlbäck grade had significantly higher serum and SF FGF-21 concentration (p < 0.001 for both). FGF-21 concentration in serum and SF was significantly and independently associated with the Ahlbäck grade (r = 0.403, p < 0.001 and r = 0.410, p < 0.001; respectively). These findings indicated that FGF-21 might be a potential biomarker for predicting bone loss of OA. Therapeutic interventions by blocking FGF-21 signaling pathways to delay the degenerative process of OA warrants further investigations.
authors.affiliation: Department of Orthopaedic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong Universtiy , Shanghai.
authors.forename: Zhan-Chun
authors.initials: ZC
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Mao-Qiang
authors.initials: MQ
authors.lastname: Li
authors.forename: Kong-Zu
authors.initials: KZ
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Wang
authors.forename: Zu-De
authors.initials: ZD
authors.lastname: Liu
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000378:metabolism; D011859:Radiography; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: Adipokine; biomarker; bone loss; fibroblast growth factor-21; osteoarthritis