title: [Compulsive molecular hoarding enables the evolution of protein-coding DNA from non-coding DNA].
abstract: It was thought until recently that a new gene could only evolve from a previously existing gene, from recombination of genes, or from horizontal gene transfer. Recently a series of genomic and transcriptomic studies have led to the identification of non-coding DNA as a significant source of protein coding genes. The mechanism, which is probably universal since it has been identified in a wide array of eukaryotes, implies that a gradient of proto-genes, probably established by a balance between selection and genetic drift, exists between coding DNA and non-coding DNA. Therefore genome dynamics could account for the progressive formation of genes "out of the blue" thanks to the interplay of mutation and natural selection.
authors.affiliation: Laboratoire évolution, génome et spéciation, UPR 9034 CNRS, avenue de la Terrasse, 91198 Gif-sur-Yvette, France université Paris-Diderot, UFR des sciences du vivant, Paris, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Casane
authors.affiliation: Laboratoire évolution, génome et spéciation, UPR 9034 CNRS, avenue de la Terrasse, 91198 Gif-sur-Yvette, France université Paris-Diderot, UFR des sciences du vivant, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Laurenti
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004247:DNA / Q000235:genetics*; D019143:Evolution, Molecular; D040961:Genetic Drift; D016678:Genome / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics; D012641:Selection, Genetic
chemical_list: D011506:Proteins; D004247:DNA