title: How far are we from the clinical use of placental-derived mesenchymal stem cells?
abstract: In recent years, multiple studies have investigated the biology and clinical applications of mesenchymal stem cells (MSCs), trying to define their markers, and elucidate their effects in animal models. MSCs are available from different tissues, and the use of placental-derived MSCs (PMSCs) for treating a variety of disorders is on the forefront. Herein, we discuss the most recent findings regarding the standardization of their isolation procedure and phenotype, along with advantages and limitations of their use. We also discuss the safety of the placental cell products, including the issue of senescence and mutagenesis of PMSCs, and efficacy from preclinical studies.
authors.affiliation: Bambino Gesù Children's Hospital, Autoimmunity Laboratory, Immunology and Pharmacotherapy Area , IRCCS, Viale S. Paolo 15, 00146 Rome , Italy +39 06 6859 2656 ; +39 06 6859 2904 ; alessandra.fierabracci@opbg.net.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fierabracci
authors.forename: Lorenza
authors.initials: L
authors.lastname: Lazzari
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muraca
authors.forename: Ornella
authors.initials: O
authors.lastname: Parolini
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D045164:Mesenchymal Stem Cell Transplantation / Q000639:trends*; D059630:Mesenchymal Stem Cells / Q000502:physiology; D010920:Placenta / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D011247:Pregnancy
keywords: isolation procedure; phenotype; placenta; placental mesenchymal stem cells; safety; stability; therapeutic application; tumorigenesis