title: Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging.
abstract: Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: B
authors.initials: B
authors.lastname: Ghetti
authors.forename: A L
authors.initials: AL
authors.lastname: Oblak
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
authors.forename: K A
authors.initials: KA
authors.lastname: Johnson
authors.forename: B C
authors.initials: BC
authors.lastname: Dickerson
authors.forename: M
authors.initials: M
authors.lastname: Goedert
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010766:Phosphorylation; D049268:Positron-Emission Tomography; D020033:Protein Isoforms / Q000235:genetics; D014055:Tomography, Emission-Computed; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D020033:Protein Isoforms; D016875:tau Proteins
keywords: FTDP-17 MAPT; Pick body; [F18]-T807; neurofibrillary tangle; tau; tau aggregation