title: Curcumin-incorporated albumin nanoparticles and its tumor image.
abstract: Albumin is an ideal carrier for hydrophobic drugs. This paper reports a facile route to develop human serum albumin (HSA)-curcumin (CCM) nanoparticles, in which β-mercaptoethanol (β-ME) acted as an inducer and CCM acted as a bridge. Fluorescence quenching and conformational changes in HSA-CCM nanoparticles occurred during assembly. Disulfide bonds and hydrophobic interactions may play a key role in assembly. HSA-CCM nanoparticles were about 130 nm in size, and the solubility of CCM increased by more than 500 times. The HSA-CCM nanoparticles could accumulate at the cytoplasm of tumor cells and target the tumor tissues. Therefore, HSA nanoparticles fabricated by β-ME denaturation are promising nanocarriers for hydrophobic substances from chemotherapy drugs to imaging probes.
authors.affiliation: Department of Research and Development, Nanjing Kaisirui Biotechnology Nanjing, People's Republic of China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Gong
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Pan
authors.forename: Kaikai
authors.initials: K
authors.lastname: Wang
authors.forename: Rongchun
authors.initials: R
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D003474:Curcumin / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D008623:Mercaptoethanol / Q000031:analogs & derivatives / Q000627:therapeutic use; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D010316:Particle Size; D012709:Serum Albumin / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D012709:Serum Albumin; D008623:Mercaptoethanol; D003474:Curcumin