title: Hypoglycemic and antihyperglycemic activity of Saptarangyadi Ghanavati: An Ayurvedic compound formulation.
abstract: BACKGROUND
  Diabetes mellitus is a persistent health problem that requires innovative strategies to improve health and needs a multifactorial approach for the treatment. Saptarangyadi Ghanavati, a formulated Ayurvedic compound consists of herbs with anti-diabetic potential.
  
  
  OBJECTIVE
  To evaluate the hypoglycemic and antihyperglycemic activities of Saptarangydi Ghanavati.
  
  
  METHODS
  For hypoglycemic activity 18 Swiss albino mice were divided into three groups (6 in each). First group served as normal control, second group is the test drug and third is the standard control group. For antihyperglycemic activity 24 Swiss albino mice were divided into four groups (6 in each). First group served as water control, second negative control, third test drug and fourth as standard control group. Test drug Saptarangydi Ghanavati was suspended in water and administered to animals at the dose of 400 mg/kg. Glibenclamide was used as reference standard in both the models at the dose of 0.65 mg/kg.
  
  
  RESULTS
  Saptarangyadi Ghanavati showed mild reduction in Blood Sugar Level (BSL) at all the time intervals in normoglycemic mice; however, the observed decrease of BSL was found to be statistically non significant. In antihyperglycemic activity, even though the drug failed to cease the hyperglycemia in the first hour after the glucose overload, it attenuated the same in later hours in nonsignificant extent.
  
  
  CONCLUSIONS
  The study reveals that Saptarangydi Ghanavati has moderate hypoglycemic and antihyperglycemic effect.
authors.affiliation: Department of Kayachikitsa, SKSS Ayurvedic College, Sarabha, Ludhiana, Punjab, India.
authors.forename: Kanwar Samrat
authors.initials: KS
authors.lastname: Singh
authors.affiliation: Research and Development, The Himalaya Drug Company, Bengaluru, Karnataka, India.
authors.forename: B K
authors.initials: BK
authors.lastname: Ashok
authors.affiliation: Department of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors.forename: Mandip
authors.initials: M
authors.lastname: Kaur
authors.affiliation: SDM Research Centre for Ayurveda and Allied Sciences, Udupi, Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Ravishankar
authors.affiliation: Ch. Brahm Prakash Charak Ayurved Sansthan, New Delhi, India.
authors.forename: Hari Mohan
authors.initials: HM
authors.lastname: Chandola
keywords: Albino mice; Saptarangydi Ghanavati; antihyperglycemic; glibenclamide; hypoglycemic