title: The Effect of Krill Oil and n-3 Polyunsaturated Fatty Acids on Human Osteosarcoma Cell Proliferation and Migration.
abstract: Osteosarcoma (OS) is a neoplastic condition afflicting mostly the young, as the lesion usually occurs in areas of bone growth with tumour cells metastasising to the lungs in advanced disease. There is no real cure for the disease, with conventional drugs causing side-effects that decrease the quality of life of sufferers. Newer and safer drugs are needed, and one avenue is to use natural compounds that can stunt the growth of the tumour.
  
  
  
  In this study, two such biological entities were evaluated: krill oil and fish oil. Human OS cells were exposed to krill oil, fish oil, EPA and DHA in time-course assays lasting up to 72h.
  
  
  
  Krill oil inhibited 23, 50 and 64% of cell proliferation at 24, 48 and 72h respectively, while fish oil resulted in no significant changes although an increase was observed at 24h. Interestingly EPA and DHA promoted OS cell proliferation and migration in this neoplasia. The inhibitory effect of krill oil was comparable to 0.5 and 1µM doxorubicin, a commonly used clinical drug for OS treatment.
  
  
  
  These results indicate that krill oil may be used in combination with standard clinical practices to control primary tumour growth, and more importantly, metastasis.
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne, VIC 3021, Australia.
authors.forename: Xiao
authors.initials: X
authors.lastname: Su
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne, VIC 3021, Australia.
authors.forename: Philline
authors.initials: P
authors.lastname: Tanalgo
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, Melbourne, VIC 3021, Australia.
authors.forename: Marcel
authors.initials: M
authors.lastname: Bustos
authors.affiliation: Curtin Health Innovation Research Institute for Ageing and Chronic Disease, Bentley, WA 6102, Australia.|School of Pharmacy, Curtin University, Bentley, WA 6102, Australia.
authors.forename: Crispin R
authors.initials: CR
authors.lastname: Dass
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D033201:Euphausiacea / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects* / Q000494:pharmacology; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D009821:Oils / Q000494:pharmacology*; D012516:Osteosarcoma / Q000188:drug therapy*
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D009821:Oils
keywords: Cancer; DHA; EPA; fish oil; krill oil; osteosarcoma