title: One-pot four-component reaction for convenient synthesis of functionalized 1-benzamidospiro[indoline-3,4'-pyridines].
abstract: The one-pot four-component reaction of benzohydrazide (2-picolinohydrazide), acetylenedicarboxylate, isatins and malononitrile (ethyl cyanoacetate) with triethylamine as base catalyst afforded functionalized 1-benzamidospiro[indoline-3,4'-pyridines] in good yields. (1)H NMR spectra indicated that an equilibrium of cis/trans-conformations exist in the obtained products.
authors.affiliation: College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Jiang
authors.affiliation: College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China.
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
keywords: 1,4-dihydropyridine; acetylenedicarboxylate; benzohydrazide; multicomponent reaction; one-pot reaction; spiro[indoline-3,4'-pyridine]