title: 3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects.
abstract: The derivatives of quinolinone and triazole exhibit antitumor, antiplatelet, antidepressant, and anticonvulsant properties in diverse experimental systems. In the past decades, we have developed increasingly potent anticonvulsant agents by the structural modification of compounds derived from 3,4-DHQLO, triazole, and their analogs. Herein, we report the design and synthesis of a new series of 3,4-DHQLO and triazole and their derivatives; their anticonvulsant activity was evaluated. Moreover, we also reviewed the anticonvulsant activity of 3,4-DHQLO and triazole and their derivatives and new approaches.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
authors.affiliation: Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education; Yanbian University College of Pharmacy, Yanji 133000, PR China. zsquan@ybu.edu.cn.
authors.forename: Zhe-Shan
authors.initials: ZS
authors.lastname: Quan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D015195:Drug Design; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D006873:Hydroquinones; D014230:Triazoles; C000594238:3,4-dihydro-2(1H)-quinolinone