title: New insights of nociceptor sensitization in bone cancer pain.
abstract: BACKGROUND
  Numerous studies have shown that an intact CNS is required for the conscious perception of cancer-induced bone pain (CIBP) and that changes in the CNS are clearly evident. Accordingly, the blockage of nociceptive stimulus into the CNS can effectively relieve or markedly attenuate CIBP, revealing the clinical implication of the blockage of ongoing peripheral inputs for the control of CIBP.
  
  
  METHODS
  In this review, the heterogeneity and excitability of nociceptors in bone are covered. Furthermore, their role in initiating and maintaining CIBP is also described.
  
  
  CONCLUSIONS
  Developing mechanistic therapies to treat CIBP is a challenge, but they have the potential to fundamentally change our ability to effectively block/relieve CIBP and increase the functional status and quality of life of patients with bone metastasis. Further studies are desperately needed at both the preclinical and clinical levels to determine whether the targets as mentioned in this review are viable and feasible for patient populations.
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Department of Oncology , Beixiange 5, Xicheng District, Beijing 100053 , China +86 10 88001221 ; +86 10 88001340 ; baoyanju@126.com.
authors.forename: Baojin
authors.initials: B
authors.lastname: Hua
authors.forename: Yebo
authors.initials: Y
authors.lastname: Gao
authors.forename: Xiangying
authors.initials: X
authors.lastname: Kong
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Yanju
authors.initials: Y
authors.lastname: Bao
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000150:complications*; D015195:Drug Design; D006801:Humans; D009619:Nociceptors / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D011788:Quality of Life
keywords: G protein-coupled receptors; cancer-induced bone pain; cytokines receptor; ion channels; neurotrophin receptor; nociceptor sensitization