title: The association between asthma and invasive pneumococcal disease: a nationwide study in Korea.
abstract: The purpose of this study was to investigate the association between asthma and invasive pneumococcal disease (IPD) in Korea. A retrospective population-based cohort study was conducted using the Korean Health Insurance Review and Assessment database 2010-2011. The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428 (2011) patients with IPD were identified. There was significant difference in the prevalence of IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs. 0.01% in 2011; P<0.001). After adjusting for age and gender, patients with asthma showed over a three-fold increased risk of IPD compared with patients without asthma (adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR, 5.44; 95% CI, 4.10-7.22 in 2011; P<0.001). These findings were also significant in children (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P=0.005 / aOR, 3.26; 95% CI, 1.74-6.11 in 2011; P<0.001). Although diabetes mellitus was also significantly associated with IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95% CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P<0.001). Both children and adults with asthma are at increased risk of developing IPD.
authors.affiliation: Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Byung Ok
authors.identifier: 0000-0001-5527-0794
authors.initials: BO
authors.lastname: Kwak
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Ji Tae
authors.initials: JT
authors.lastname: Choung
authors.affiliation: Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Yong Mean
authors.identifier: 0000-0002-2586-584X
authors.initials: YM
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications / Q000453:epidemiology*; D002648:Child; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000453:epidemiology*; D053592:Interleukin-1 Receptor-Associated Kinases; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000150:complications / Q000453:epidemiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D015995:Prevalence; D000081207:Primary Immunodeficiency Diseases; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000472:pathogenicity; D055815:Young Adult
chemical_list: C538862:13-valent pneumococcal vaccine; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D053592:Interleukin-1 Receptor-Associated Kinases
keywords: Asthma; Diabetes Mellitus; Invasive Pneumococcal Disease