title: Calcium mobilizing second messengers derived from NAD.
abstract: Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca²⁺ mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinucleotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca²⁺ mobilization by these adenine nucleotides and their putative target Ca²⁺ channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.
authors.affiliation: The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: guse@uke.de.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Guse
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose / Q000502:physiology; D006801:Humans; D009243:NAD / Q000502:physiology*; D009249:NADP / Q000031:analogs & derivatives / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D009243:NAD; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D009249:NADP; C024376:NAADP; D002118:Calcium
keywords: ADP-ribose; Calcium signaling; Cofactor; Cyclic ADP-ribose; NAADP; NAD