title: MicroRNAs in Human Pituitary Adenomas.
abstract: MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10-15% of diagnosed brain tumors. Deregulated miRNAs and their targets contribute to pituitary adenomas progression and are associated with cell cycle control, apoptosis, invasion, and pharmacological treatment of pituitary adenomas. To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.
authors.affiliation: Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China ; Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang 314006, China.
authors.forename: Xu-Hui
authors.identifier: 0000-0001-7933-174X
authors.initials: XH
authors.lastname: Li
authors.affiliation: Department of Legal Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan ; Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
authors.forename: Elaine Lu
authors.initials: EL
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang 314006, China.
authors.forename: Hai-Meng
authors.identifier: 0000-0001-7639-3451
authors.initials: HM
authors.lastname: Zhou
authors.affiliation: Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan.
authors.forename: Katsuhiko
authors.identifier: 0000-0002-3209-3112
authors.initials: K
authors.lastname: Yoshimoto
authors.affiliation: Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan ; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Room M420, Boston, MA 02215, USA.
authors.forename: Zhi Rong
authors.initials: ZR
authors.lastname: Qian