title: ZEB1 expression in endometrial biopsy predicts lymph node metastases in patient with endometrial cancer.
abstract: OBJECTIVE
  The purpose of this study was to analyze the expression of zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases in patient with endometrial cancer.
  
  
  METHODS
  Using quantitative RT-PCR, ZEB1 expressions in endometrial biopsy from 452 patients were measured. The relationship between ZEB1 expression and preoperative characteristics was analyzed.
  
  
  RESULTS
  ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases. Lymph node metastases could be identified with a sensitivity of 57.8% at specificity of 74.1% by ZEB1 expression in endometrial biopsy. Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.
  
  
  CONCLUSIONS
  ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.
authors.affiliation: Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Pathology, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui 241001, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Shen
authors.affiliation: Molecular Pathological Laboratory, Maternal and Child Health Hospital of Anhui Province, Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D012372:ROC Curve; D014157:Transcription Factors / Q000378:metabolism*; D000071799:Zinc Finger E-box-Binding Homeobox 1
chemical_list: D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; D014157:Transcription Factors; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1