title: Role of ApoA1 on high-density lipoprotein: an intervention with plant sterols in patients with hypercholesterolemia.
abstract: BACKGROUND
  Numerous studies have shown an inverse association between cholesterol´s concentration associated with High-Density Lipoprotein Cholesterol (HDL-C) and cardiovascular risk. The present study intends to investigate the possible relation between Apolipoprotein A (ApoA1) and HDL-C as a new strategy to reduce cardiovascular risk.
  
  
  OBJECTIVE
  was determine the effect of ApoA1 in cholesterol ´s metabolism through its influence on HDL-C in young adult population.
  
  
  METHODS
  One clinical trial, controlled, randomized, double-blind, providing a commercial milk, "Naturcol", with sterols for 3 weeks (n = 19) and placebo (n = 16). A questionnaire Ad Hoc was designed and a complete anthropometric study was made. SPSS 21.0 was used to analyse the data.
  
  
  RESULTS
  Significant differences were observed between sterol milk and placebo in a single marker, Low-Density Lipoprotein Cholesterol (LDL-C). A linear dispersion of data between HDL-C and ApoA1 was found, both at the beginning and end of the intervention (Person Correlation = 0.846 and 0.903, respectively). High dependency measures by linear regression (R2= 0.715 and 0.816, respectively) were observed.
  
  
  CONCLUSIONS
  A significant relation between HDL-C and ApoA1 was proven. Taking into account the importance that HDL-C levels seem to have on cardiovascular health, ApoA1 is presented as an important clinical marker to improve heart function as well as to reduce cardiovascular risk.
authors.affiliation: Medicine Department, Complutense's University of Madrid. Research Centers in Nutrition and Health (CINUSA Group). Spain.. ismasmm@gmail.com.
authors.forename: Ismael
authors.initials: I
authors.lastname: San Mauro Martín
authors.affiliation: Medicine Department, Complutense's University of Madrid.. ismasmm@gmail.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Collado Yurrita
authors.affiliation: Clinical Analysis Unit, Hospital Universitario Clínico San Carlos de Madrid.. ismasmm@gmail.com.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Cuadrado Cenzual
authors.affiliation: Medicine Department, Complutense's University of Madrid.. ismasmm@gmail.com.
authors.forename: María José
authors.initials: MJ
authors.lastname: Ciudad Cabañas
authors.affiliation: Research Centers in Nutrition and Health (CINUSA Group). Spain.. ismasmm@gmail.com.
authors.forename: Paula
authors.initials: P
authors.lastname: Mendive Dubourdieu
mesh_terms: D000328:Adult; D000886:Anthropometry; D016632:Apolipoprotein A-I / Q000097:blood*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D010840:Phytosterols / Q000627:therapeutic use*
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D010840:Phytosterols