title: Role of cGMP in hydrogen sulfide signaling.
abstract: The importance of hydrogen sulfide (H2S) in physiology and disease is being increasingly recognized in recent years. Unlike nitric oxide (NO) that signals mainly through soluble guanyl cyclase (sGC)/cGMP, H2S is more promiscuous, affecting multiple pathways. It interacts with ion channels, enzymes, transcription factors and receptors. It was originally reported that H2S does not alter the levels of cyclic nucleotides. More recent publications, however, have shown increases in intracellular cGMP following exposure of cells or tissues to exogenously administered or endogenously produced H2S. Herein, we discuss the evidence for the participation of cGMP in H2S signaling and reconcile the seemingly divergent results presented in the literature on the role of this cyclic nucleotide in the biological actions of H2S.
authors.affiliation: Faculty of Pharmacy, University of Athens, Athens, Greece.
authors.forename: Sofia-Iris
authors.initials: SI
authors.lastname: Bibli
authors.affiliation: School of Kinesiology, Cardiovascular and Metabolic Research Unit (CMRU), Lakehead University, Thunder Bay, Ontario, Canada.
authors.forename: Guangdong
authors.initials: G
authors.lastname: Yang
authors.affiliation: "G. P. Livanos" Laboratory, First Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens, Athens, Greece.
authors.forename: Zongmin
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Topouzis
authors.affiliation: Faculty of Pharmacy, University of Athens, Athens, Greece; "G. P. Livanos" Laboratory, First Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens, Athens, Greece. Electronic address: apapappet@pharm.uoa.gr.
authors.forename: Andreas
authors.initials: A
authors.lastname: Papapetropoulos
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction
chemical_list: D006152:Cyclic GMP; D006862:Hydrogen Sulfide
keywords: Angiogenesis; Hydrogen sulfide; PKG; Relaxation; cGMP