title: RBC acetyl cholinesterase: A poor man's early diagnostic biomarker for familial alzheimer's and Parkinson's disease dementia.
abstract: OBJECTIVE
  Analysis of red blood cell acetyl cholinesterase (AChE) in a familial Alzheimer's diseases (AD) Parkinson's disease dementia (PDD) and their first generation.
  
  
  METHODS
  General hospital, Mahad district, Raigad.
  
  
  METHODS
  Clinically diagnosed patients of AD and PDD and their asymptomatic relatives. Their blood was collected in EDTA tube and transferred to laboratory at Mumbai.
  
  
  RESULTS
  Median red blood cell (RBC) cholinesterase levels amongst PDD, their first generation asymptomatic relatives, familial AD, asymptomatic relatives of AD, healthy controls, farmers exposed to pesticides (positive control) and other neurological condition without dementia (hypertension with TIA 1, sub-dural hematoma 2, hypothyroid 1, non-familial unilateral parkinsonism without dementia 3, writers cramps 2, hyponitremia 1 and cerebral palsy with non-fluent aphasia 1). Median values of RBC AChE were 19086.78 U/L, 15666.05 U/L, 9013.11 U/L, 7806.19 U/L, 14334.57 U/L, 9785.05 U/L and 13162.60 U/L, respectively. As compared to controls, RBC AChE levels were statistically significant among PDD (P = 0.004) and significantly lowered among familial AD patients (P = 0.010), relatives of patients (P = 0.010).
  
  
  CONCLUSIONS
  Below the normal RBC AChE level is a potential biomarker in asymptomatic relatives of familial AD patients. RBC AChE is raised than normal level in patients suffering from PDD, where AChE inhibitors are helpful. However, RBC AChE level below the normal where AChE inhibitor may not be effective.
authors.affiliation: Department of General Medicine, Bawaskar Hospital and Clinical Research Center, Mahad, Maharashtra, India.
authors.forename: Himmatrao Saluba
authors.initials: HS
authors.lastname: Bawaskar
authors.affiliation: Department of Medicine, BYL NAIR Hospital and Topiwala Medical College, Mumbai, India.
authors.forename: Parag Himmatrao
authors.initials: PH
authors.lastname: Bawaskar
authors.affiliation: Department of General Medicine, Bawaskar Hospital and Clinical Research Center, Mahad, Maharashtra, India.
authors.forename: Pramodini Himmatrao
authors.initials: PH
authors.lastname: Bawaskar
keywords: Acetyl choline; Alzheimer's diseases; Parkinson's diseases dementia; acetyl cholinesterase inhibitors; donepzil; mementine