title: IAPs: Modular regulators of cell signalling.
abstract: Members of the inhibitor of apoptosis (IAP) family are characterised by the presence of at least one baculoviral IAP repeat (BIR) domain. However, during the course of evolution, other globular modules have been adopted to perform distinct functions. Consequently, the IAP family is now recognised as consisting of members that perform critical functions in different aspects of cellular regulation. In this review, the structural diversity present within the IAP protein family is presented. Known structures of individual domains are discussed and their properties are described in light of recent data. In particular the plasticity of BIR domains and their ability to accommodate different binding partners is highlighted, as well as the importance of communication between the domains in regulating the covalent attachment of ubiquitin.
authors.affiliation: Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand.
authors.forename: Rhesa
authors.initials: R
authors.lastname: Budhidarmo
authors.affiliation: Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand. Electronic address: catherine.day@otago.ac.nz.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Day
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D054730:Protein Interaction Domains and Motifs; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: D051034:Inhibitor of Apoptosis Proteins
keywords: BIR; Domain; IAP; RING; Ubiquitin