title: Pioglitazone may impair L-DOPA anti-parkinsonian efficacy in the MPTP-lesioned macaque: results of a pilot study.
abstract: In this pilot study, pioglitazone, an agonist of the peroxisome proliferator-activated receptor gamma (PPAR-γ) used in the treatment of diabetes mellitus, was administered to dyskinetic parkinsonian macaques. Pioglitazone alleviated L-DOPA-induced dyskinesia, but impaired L-DOPA anti-parkinsonian efficacy. These results suggest caution when administering pioglitazone to patients with advanced Parkinson's disease.
authors.affiliation: Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Neurology, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Huot
authors.forename: Tom H
authors.initials: TH
authors.lastname: Johnston
authors.forename: Susan H
authors.initials: SH
authors.lastname: Fox
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Brotchie
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy; D005260:Female; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D020267:MPTP Poisoning / Q000188:drug therapy*; D008252:Macaca fascicularis; D010865:Pilot Projects; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; D045162:Thiazolidinediones; D007980:Levodopa; D000077205:Pioglitazone
keywords: L-DOPA; MPTP-lesioned macaque; ON-time; dyskinesia; pioglitazone