title: TUMORS OF THE NONPIGMENTED EPITHELIUM OF THE CILIARY BODY: The Lorenz E. Zimmerman Tribute Lecture.
abstract: BACKGROUND
  In 1970, Dr. Lorenz Zimmerman delivered the Norman McAlister Gregg Lecture entitled "The remarkable polymorphism of tumors of the ciliary epithelium." Therein, he proposed a classification of these tumors that included congenital lesions (mainly medulloepithelioma) and acquired lesions (mainly adenoma and adenocarcinoma). The classification was based on histopathologic observations without detailed clinical information.
  
  
  METHODS
  Review of the published literature and personal experience with tumors of the nonpigmented ciliary body epithelium.
  
  
  RESULTS
  Since 1970, further observations through clinical examination and advanced testing with ultrasound biomicroscopy, anterior segment optical coherence tomography, and magnetic resonance imaging have expanded our knowledge regarding tumors of the nonpigmented ciliary body epithelium. Regarding medulloepithelioma, we have learned of the common associated features of neovascular glaucoma, retrolenticular neoplastic or vascular cyclitic membrane, intralesional cysts, response to radiotherapy, and association with Dicer-1 mutation. Regarding adenoma/adenocarcinoma, improved management with surgical resection (sparing globe) can be achieved. Fuchs adenoma, also termed coronal adenoma, is commonly found histopathologically, despite its rare clinical visualization, and should be added to the Zimmerman classification.
  
  
  CONCLUSIONS
  Since Zimmerman's report on histopathologic features of tumors of the nonpigmented ciliary body epithelium, there have been numerous publications and further observations on the clinical features and management of these intriguing neoplasms.
authors.affiliation: *Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and †Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
authors.forename: Kyle
authors.initials: K
authors.lastname: Ferguson
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology*; D000236:Adenoma / Q000145:classification / Q000473:pathology*; D002924:Ciliary Body / Q000473:pathology*; D006801:Humans; D018242:Neuroectodermal Tumors, Primitive / Q000145:classification / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D014604:Uveal Neoplasms / Q000145:classification / Q000473:pathology*