title: Primary lymphoepithelioma-like carcinoma of salivary glands: a clinicopathological study of 21 cases.
abstract: Lymphoepithelioma-like carcinoma (LELC) of salivary glands is a rare kind tumor. In this study, the authors evaluated 21 patients with LELC of salivary glands who had long-term follow-up. Clinical characteristics, Epstein-Barr virus (EBV) infection, immunohistochemical features, oncoprotein expression, treatments, and outcomes were analyzed. All patients were Chinese. Their ages ranged from 20 to 73 years. All tumors showed the typical syncytial growth pattern of undifferentiated epithelial cells with a significant lymphocyte reaction. All of patients were found by in situ hybridization to have the EBV genome. All tumors showed positive immunostaining of AE1/AE3, CK5/6 and p63. Nearly all cases had bcl-2 oncoprotein expression, but the detection rate of p53, and c-erb B-2 expression was extremely low. LELC of salivary glands is a distinct entity of salivary cancer. LELC of salivary glands can receive multimodality treatment and has a better prognosis similar to that of nasopharyngeal carcinoma.
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Deng
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Xie
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Tong-Bing
authors.initials: TB
authors.lastname: Chen
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pathology, The First People's Hospital of Changzhou and Third Affiliated Hospital of Suzhou University Changzhou 213003, China.
authors.forename: Zhao-Li
authors.initials: ZL
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D013365:Submandibular Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D012367:RNA, Viral
keywords: Epstein-Barr virus; Lymphoepithial carcinoma; bcl-2; oncogenes; prognosis; salivary gland