title: Aging and the muscle-bone relationship.
abstract: Aging-induced declines in muscle size and quality are thought to contribute to catabolic alterations in bone, but changes in bone with age also profoundly alter its response to muscle-derived stimuli. This review provides an overview of some of the alterations that occur in muscle and bone with aging, and discusses the cellular and molecular mechanisms that may impact these age-associated changes.
authors.affiliation: Orthopedic Research Department, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota; snovotny@gillettechildrens.com.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Novotny
authors.affiliation: Department of Physical Therapy, Georgia State University, Atlanta, Georgia; and.
authors.forename: Gordon L
authors.initials: GL
authors.lastname: Warren
authors.affiliation: Cellular Biology & Anatomy, Georgia Regents University, Augusta, Georgia.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Hamrick
mesh_terms: D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D002113:Calcification, Physiologic / Q000502:physiology*; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000166:cytology* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology