title: Ultrasound mediated, iodine catalyzed green synthesis of novel 2-amino-3-cyano-4H-pyran derivatives.
abstract: An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bangalore 560 001, India.
authors.forename: Sumaiya
authors.initials: S
authors.lastname: Tabassum
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bangalore 560 001, India.
authors.forename: Santhosh
authors.initials: S
authors.lastname: Govindaraju
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bangalore 560 001, India.
authors.forename: Riyaz-ur-Rahaman
authors.initials: RU
authors.lastname: Khan
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Palace Road, Bangalore 560 001, India. Electronic address: m_af_pasha@ymail.com.
authors.forename: Mohamed Afzal
authors.initials: MA
authors.lastname: Pasha
keywords: 2-Amino-3-cyano-4H-pyrans; Active methylene compounds; Heteroaryl aldehydes; Malononitrile; Multi-component reactions; Ultrasonic irradiation