title: The DISCUSS Project: Revised Points to Consider for the Derivation of Induced Pluripotent Stem Cell Lines From Previously Collected Research Specimens.
abstract: Human somatic cell reprogramming is a leading technology for accelerating disease modeling and drug discovery. The Deriving Induced Stem Cells Using Stored Specimens (DISCUSS) project is a consensus-building initiative designed to consider how human somatic cells obtained under general biomedical research protocols can be used in induced pluripotent stem cell (iPSC) derivation. We previously published a draft list of points to consider for the use of previously collected specimens in iPSC research and then initiated a structured feedback and comment process. Here, we present a summary of this feedback and revised list of points to consider.
authors.affiliation: California Institute for Regenerative Medicine, San Francisco, California, USA; glomax@cirm.ca.gov glomax@lmi.net.
authors.forename: Geoffrey P
authors.initials: GP
authors.lastname: Lomax
authors.affiliation: Office of the Clinical Director, National Human Genome Research Institute and Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA;
authors.forename: Sara Chandros
authors.initials: SC
authors.lastname: Hull
authors.affiliation: Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
authors.forename: Rosario
authors.initials: R
authors.lastname: Isasi
mesh_terms: D002460:Cell Line; D055808:Drug Discovery; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D013048:Specimen Handling; D057905:Stem Cell Research