title: Cytokines, IBD, and colitis-associated cancer.
abstract: Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis-associated cancer. Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and colitis-associated cancer. In this review, we will explore the functions of many key cytokines and their roles in IBD and colitis-associated cancer, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
authors.forename: Ralph
authors.initials: R
authors.lastname: Francescone
authors.forename: Vivianty
authors.initials: V
authors.lastname: Hou
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Grivennikov
mesh_terms: D000818:Animals; D003092:Colitis / Q000150:complications*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology*; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D016207:Cytokines