title: Polyethylenimine-grafted cellulose nanofibril aerogels as versatile vehicles for drug delivery.
abstract: Aerogels from polyethylenimine-grafted cellulose nanofibrils (CNFs-PEI) were developed for the first time as a novel drug delivery system. The morphology and structure of the CNFs before and after chemical modification were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Water-soluble sodium salicylate (NaSA) was used as a model drug for the investigation of drug loading and release performance. The CNFs-PEI aerogels exhibited a high drug loading capability (287.39 mg/g), and the drug adsorption process could be well described by Langmuir isotherm and pseudo-second-order kinetics models. Drug release experiments demonstrated a sustained and controlled release behavior of the aerogels highly dependent on pH and temperature. This process followed quite well the pseudo-second-order release kinetics. Owing to the unique pH- and temperature-responsiveness together with their excellent biodegradability and biocompatibility, the CNFs-PEI aerogels were very promising as a new generation of controlled drug delivery carriers, offering simple and safe alternatives to the conventional systems from synthetic polymers.
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute at Sichuan University , No. 24 South Section 1, Yihuan Road, Chengdu 610065, China.
authors.forename: Jiangqi
authors.initials: J
authors.lastname: Zhao
authors.forename: Canhui
authors.initials: C
authors.lastname: Lu
authors.forename: Xu
authors.initials: X
authors.lastname: He
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Ximu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005782:Gels / Q000737:chemistry; D007700:Kinetics; D057139:Nanofibers / Q000737:chemistry*; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000737:chemistry; D012980:Sodium Salicylate / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; C018367:polyethyleneimine-cellulose; D011094:Polyethyleneimine; D002482:Cellulose; D012980:Sodium Salicylate
keywords: aerogel; cellulose nanofibrils (CNFs); controlled release; drug delivery; polyethylenimine (PEI)