title: Laparoscopic versus open distal pancreatectomy for ductal adenocarcinoma: a systematic review and meta-analysis.
abstract: BACKGROUND
  Laparoscopic distal pancreatectomy was proposed as an oncologically safe approach for pancreatic ductal adenocarcinoma.
  
  
  METHODS
  A systematic review of the studies comparing laparoscopic and open distal pancreatectomy was conducted. The primary endpoint was an R0 resection rate. The secondary endpoints were intra- and postoperative results, tumour size, mean harvested lymph node, number of patients eligible for adjuvant therapy and overall survival.
  
  
  RESULTS
  Five comparative case control studies involving 261 patients (30.7% laparoscopic and 69.3% open) who underwent a distal pancreatectomy were included. The R0 resection rate was similar between the two groups (P = 0.53). The laparoscopic group had longer operative times (P = 0.04), lesser blood loss (P = 0.01), a shorter hospital stay (P < 0.001) and smaller tumour size (P = 0.04) as compared with the laparotomic group. Overall morbidity, postoperative pancreatic fistula, reoperation, mortality and number of patients eligible for adjuvant therapy were similar. The mean harvested lymph nodes were comparable in the two groups (P = 0.33). The laparoscopic approach did not affect the overall survival rate (P = 0.32).
  
  
  CONCLUSIONS
  Even if the number of patients compared is underpowered, the laparoscopic approach in the treatment of PDAC seems to be safe and efficacious. However, additional prospective, randomised, multicentric trials are needed to correctly evaluate the laparoscopic approach in PDAC.
authors.affiliation: Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Chirurgia Generale-Minni, Alma Mater Studiorum-Università di Bologna, Policlinico S.Orsola-Malpighi Via Massarenti n, 9 40138, Bologna, Italy, claudiochir@gmail.com.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ricci
authors.forename: Riccardo
authors.initials: R
authors.lastname: Casadei
authors.forename: Giovanni
authors.initials: G
authors.lastname: Taffurelli
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Toscano
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Pacilio
authors.forename: Selene
authors.initials: S
authors.lastname: Bogoni
authors.forename: Marielda
authors.initials: M
authors.lastname: D'Ambra
authors.forename: Nico
authors.initials: N
authors.lastname: Pagano
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Di Marco
authors.forename: Francesco
authors.initials: F
authors.lastname: Minni
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000601:surgery*