title: Association of Interleukin-10 promotor polymorphisms with atrial fibrillation in Han Chinese.
abstract: There is an accumulating body of evidence indicating strong association between inflammation and the pathogenesis of atrial fibrillation (AF). IL-10 is a multifunctional anti-inflammatory cytokine that down-regulates cell-mediated immune responses and cytotoxic inflammatory responses. The aim of the present study is to investigate the association of IL-10 gene -592A/C polymorphism with AF in Han Chinese. 117 AF patients and 100 healthy volunteers were eligible for this study. The PCR-based restriction fragment length polymorphism (PCR-RFLP) technique was used to assess the genotypes frequencies. The distribution of the IL-10 -592A/C genotypes (AA, AC, and CC) was 55.00%, 35.00%, and 10.00% in the controls, and 71.79%, 23.08%, and 5.13% in AF subjects, respectively (p = 0.0335). The frequency of the A allele in the AF group was significantly higher than that in the control group (83.33% vs 72.50%, p = 0.0063). Compared with the CC genotype, the AA genotype had increased risk of AF in both unadjusted and adjusted analyses. The average serum IL-10 levels in AA genotype were statistically lower than in AC + CC genotype (p = 0.0000). These findings suggest that IL-10 -592A/C polymorphism is associated with AF and the A allele has increased risk for AF in Han Chinese.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Haian Hospital of Traditional Chinese Medicine Haian 226600, P. R. China.
authors.forename: Shun-Nian
authors.initials: SN
authors.lastname: Ji
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Xinghua People's Hospital Xinghua 225700, P. R. China.
authors.forename: Xin-Tao
authors.initials: XT
authors.lastname: Deng
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Ya-Min
authors.initials: YM
authors.lastname: Su
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Pan
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Cai
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Li
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Affiliated Hospital of Nantong University Nantong 226001, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Pan
keywords: Atrial fibrillation; Chinese; genetic polymorphism; interleukin-10