title: Recurrence and death from breast cancer after complete treatments: an experience from hospitals in Northern Thailand.
abstract: OBJECTIVE
  To describe the pattern of disease progression and to describe locoregional recurrence, distant recurrence, and death rates in breast cancer patients after complete treatment.
  
  
  METHODS
  Medical records of women diagnosed with breast cancer at two university affiliated tertiary care hospitals in the Northern Thailand that had complete treatments between 2006 and 2010 were traced. Extracted key information included patient clinical profiles and documented recurrence of cancer The causes of death were verified from breast cancer case registration database, death certificates through The Ministry of Internal Affairs'civil registration, by direct telephone contact, or by distributed prepaid postcards.
  
  
  RESULTS
  Medical records of 829 women diagnosed with breast cancer without prior evidence ofdistant metastasis, and had complete recommended treatment were included. Six hundred thirty seven women had not experienced any events up to the end of the follow-up (76.8%). The first occurring events were focused and categorized into three distinct types, locoregional recurrence (n = 83, median follow-up time = 34.2 months), distant recurrence (n = 78, median follow-up time = 35.4 months), and death without any evidences of locoregional or distant recurrences (n = 12, median follow-up time = 36.7 months). Distant recurrence after locoregional recurrence was reported (n = 33). There were 109 patient who had died (breast cancer related death) up to the end of the follow-up (13.2%). The three types of consecutively occurring deaths were death after locoregional recurrence without any distant recurrences (n = 15), death after distant recurrence with locoregional recurrence (n = 21), and death after documenited distant recurrence without any locoregional recurrences (n = 61).
  
  
  CONCLUSIONS
  The trend was that the rate of the first occurring locoregional recurrence was slightly higher than that of distant recurrence, The death rate in patients without any recurrences was much lower than in those experiencing prior recurrences. The rates of disease progression from local recurrence to distant recurrence and to death were approximately 5 to 7 times faster in patients who had experienced earlierprogressions.
authors.forename: Rungnapa
authors.initials: R
authors.lastname: Chairat
authors.forename: Adisom
authors.initials: A
authors.lastname: Puttisri
authors.forename: Asani
authors.initials: A
authors.lastname: Pamarapa
authors.forename: Nongnoot
authors.initials: N
authors.lastname: Wongrach
authors.forename: Chamaiporn
authors.initials: C
authors.lastname: Tawichasri
authors.forename: Jayanton
authors.initials: J
authors.lastname: Patumanond
authors.forename: Apichat
authors.initials: A
authors.lastname: Tantraworasin
authors.forename: Chaiyut
authors.initials: C
authors.lastname: Charoentum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D016019:Survival Analysis; D013785:Thailand / Q000453:epidemiology