title: High serum uric acid level in adolescent depressive patients.
abstract: BACKGROUND
  Depression disorder is a mental illness of high recurrence rate and its pathological mechanism is still unclear. 5-HT is the most widely studied neurotransmitter and high level of serum uric acid (SUA) can result from the increased oxygenolysis of nucleic acid. Aim of the present study is to explore the pathogenesis of adolescence depression through the study of SUA and 5-HT level in adolescent depressive patients.
  
  
  METHODS
  The SUA of 152 adolescent depressive patients and normal adolescents were tested respectively and 5-HT levels among them were analyzed.
  
  
  RESULTS
  The SUA level of cases (434.57±102.34μmol/L) was significantly higher than controls (330.18±62.59μmol/L), P<0.001; the 5-HT level of cases (20.86±4.58) was significantly lower than controls (24.03±5.76) (P<0.005) and had a significant negative correlation with SUA level (r=-0.49, P<0.01).
  
  
  CONCLUSIONS
  The sample size was relatively small and the patients were only male from General Hospital of Beijing Military Region.
  
  
  CONCLUSIONS
  High level of SUA can be used as a biochemical index for the early diagnose of adolescence depression; adolescence depression may be due to DNA oxidative damage of neurons in brain.
authors.affiliation: Addiction Medicine Center, General Hospital of Beijing Military Region, No. 5, Nanmencang, Dongsishitiao, Dongcheng District, Beijing 100700, PR China. Electronic address: bjptaoran@126.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.affiliation: Beijing Shijian Integrated Medicine Science Institute, Beijing 100700, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000097:blood / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D058256:Brain Waves / Q000502:physiology; D016022:Case-Control Studies; D003863:Depression / Q000097:blood* / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D008297:Male; D012701:Serotonin / Q000378:metabolism; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D012701:Serotonin
keywords: 5-HT; Depression; Metabolic disease; Serum uric acid