title: Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones.
abstract: The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael addition/lactamisation cascade gives access to a range of dihydropyridinones with high enantioselectivity. The nature of the N-sulfonyl group present on the ketimine is extensively investigated, with further studies into derivatisation of the dihydropyridinone core also reported.
authors.affiliation: EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK. ads10@st-andrews.ac.uk.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Yeh
authors.forename: David S B
authors.initials: DS
authors.lastname: Daniels
authors.forename: Charlene
authors.initials: C
authors.lastname: Fallan
authors.forename: Eoin
authors.initials: E
authors.lastname: Gould
authors.forename: Carmen
authors.initials: C
authors.lastname: Simal
authors.forename: James E
authors.initials: JE
authors.lastname: Taylor
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Smith