title: Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5.
abstract: Atoh1, Hes1 and Hes5 are crucial for normal inner ear hair cell development. They regulate the expression of each other in a complex network, while they also interact with many other genes and pathways, such as Notch, FGF, SHH, WNT, BMP and RA. This paper summarized molecular pathways that involve Atoh1, Hes1, and Hes5. Some of the pathways and gene regulation mechanisms discussed here were studied in other tissues, yet they might inspire studies in inner ear hair cell development. Thereby, we presented a complex regulatory network involving these three genes, which might be crucial for proliferation and differentiation of inner ear hair cells.
authors.affiliation: The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yi-Xun
authors.initials: YX
authors.lastname: Su
authors.affiliation: The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Hou
authors.affiliation: The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wxyang@spermlab.org.
authors.forename: Wan-Xi
authors.initials: WX
authors.lastname: Yang
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D006198:Hair Cells, Auditory / Q000166:cytology* / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins
keywords: Atoh1; Hair cell; Hes1; Hes5; Inner ear