title: Stem cells as a new treatment for peripheral artery disease: hype or hope? The point of view of a vascular surgeon.
abstract: Because many of patients with peripheral arterial disease are not eligible for direct or conventional revascularization procedures, because stem cell therapy is being investigated as to its possible role in the treatment of limb ischemia, there is a need to evaluate this treatment and his true application. On the basis of experimental data, preliminary clinical studies have established the safety and feasibility of stem cells implantation in case of critical limb ischemia. Forthcoming large studies, especially randomized placebo controlled double blind studies, related to the optimal cell type, dosage, administration route, will consolidate this evidence and establish mid and long term effectiveness.
authors.affiliation: Pôle Vaisseaux Vascular Center, Laxou, France Louis Pasteur Clinic, Essey-lès-Nancy, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lehalle
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D016896:Treatment Outcome
keywords: Cell therapy; critical limb ischemia; mesenchymal stem cells; peripheral artery disease