title: Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.
abstract: BACKGROUND
  Accumulated evidence has indicated that ataxia-telangiectasia mutated (ATM) gene polymorphisms are closely related to lung cancer. We aimed to explore the prognostic value of rs189037 (G>A), one of ATM single nucleotide polymorphisms (SNPs), and detect whether it involves in the risk of lung cancer in Chinese Han people.
  
  
  METHODS
  In this hospital-based matched case-control study, 852 lung cancer patients and 852 healthy controls have been put into comparison to analyze the association between rs189037 and lung cancer risk in Chinese. The single nucleotide polymorphisms were determined by TaqMan real-time PCR and we used SPSS software to perform the statistical analyses.
  
  
  RESULTS
  Individuals carrying variant AA genotype of rs189037 had higher lung cancer risk (adjusted OR: 1.56) than those carrying GG genotype. After analyzing data respectively from different groups divided by genders and smoking status, we observed that the risk effect of AA genotype on the lung cancer was significant in females, non-smokers and female non-smokers, as well as the risk effect of GA genotype in male smokers. Compared with non-smokers carrying GG genotype, smokers carrying at least one A allele had higher risk of developing lung cancer than those with GG genotype (adjusted OR: 3.52 vs. adjusted OR: 2.53).
  
  
  CONCLUSIONS
  This study suggested that rs189037 (G>A) polymorphism is associated with lung cancer risk in Chinese Han population. AA genotype and A allele may be dangerous lung cancer signals in Chinese and make contribution to diagnostic and treatment value.
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China; Clinical Medicine of Seven System, China Medical University, Shenyang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China; Clinical Medicine of Seven System, China Medical University, Shenyang, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
authors.forename: Yangwu
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
authors.forename: Xichen
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
authors.forename: Baosen
authors.initials: B
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics; D001260:Ataxia Telangiectasia / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects