title: Should insulin resistance be screened in lean hirsute women?
abstract: The role of insulin resistance (IR) is well-documented in obese women with polycystic ovary syndrome (PCOS). Controversies exist concerning the presence of IR in idiopathic hirsutism (IH) or if it is a manifestation of high body mass index (BMI). We aimed to investigate the presence/absence of IR in lean hirsute women. One-hundred fifty-one lean women with hirsutism [96 PCOS (group 1) and 55 IH (group 2)] and 58 age-and BMI-matched healthy controls (group 3) were recruited in the study (mean age 25.21 ± 6.1 versus 26.26 ± 4.6years; BMI 21.79 ± 1.7 versus 22.02 ± 2.2 kg/m(2), respectively). Significantly higher insulin and HOMA-IR, and significantly lower fasting glucose insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), reciprocal insulin, and Raynaud index were detected in groups 1 and 2 than in group 3 (p < 0.05). These IR indices were similar between groups 1 and 2. The number of patients with IR (HOMA-IR > 2, FGIR < 7.2, or QUICKI < 0.357) was significantly higher in groups 1 and 2 than in group 3, but was similar between groups 1 and 2. A higher frequency of IR occurs in lean hirsute women regardless of they having PCOS or IH. IR may contribute to aetiopathogenesis of IH, or may cause some metabolic abnormalities in these patients.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes, Endocrine and Obesity Branch, National Institutes of Health , Bethesda, MD , USA .
authors.forename: Ayse
authors.initials: A
authors.lastname: Arduc
authors.forename: Orkun
authors.initials: O
authors.lastname: Sarıcam
authors.forename: Bercem Aycicek
authors.initials: BA
authors.lastname: Dogan
authors.forename: Mazhar Muslum
authors.initials: MM
authors.lastname: Tuna
authors.forename: Yasemin Ates
authors.initials: YA
authors.lastname: Tutuncu
authors.forename: Serhat
authors.initials: S
authors.lastname: Isik
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: Engin
authors.initials: E
authors.lastname: Sennaroglu
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D044882:Glucose Metabolism Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006628:Hirsutism / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D006784:Hospitals, Teaching; D006786:Hospitals, Urban; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology; D017410:Practice Guidelines as Topic; D012306:Risk; D013851:Thinness; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Insulin resistance; idiopathic hirsutism; lean women; polycystic ovary syndrome