title: Ovariectomy-associated changes in interradicular septum and in tibia metaphysis in different observation periods in rats.
abstract: In order to standardize an experimental model to study the effects of absence of ovarian hormones in maxillary bones compared with long bones, the aim of this research was to analyze the influence of ovariectomy (OVX) on rat alveolar bone and tibiae, in different observation periods. Thirty-six female rats were ovariectomized or sham operated. After 60, 90 or 120 days, the animals were sacrificed and their hemimandibles, maxillae and tibiae were removed and routinely prepared for hematoxylin and eosin staining. The percentage of bone matrix area in bone septum in the first molar furcation region, and in tibial metaphysis was calculated, and data were submitted to statistical analysis (p<0.05). As regards the histomorphometrical analysis in jaw bones, there was no statistical difference between groups, while the effects of ovariectomy on tibiae were seen as early as 60 days. According to the methods used, there was no significant influence of absence of ovarian hormones on interradicular septum of mandibular or maxillary first molars in the periods studied, despite the reduction in bone matrix area in tibia metaphysis as early as 60 days.
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil.
authors.forename: Carina M
authors.initials: CM
authors.lastname: Esteves
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil.
authors.forename: Renata M
authors.initials: RM
authors.lastname: Moraes
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil.
authors.forename: Francine C
authors.initials: FC
authors.lastname: Gomes
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil.
authors.forename: Meryenn S
authors.initials: MS
authors.lastname: Marcondes
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil.
authors.forename: Gabriela M G
authors.initials: GM
authors.lastname: Lima
authors.affiliation: Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Universidade Estadual Paulista-UNESP, Av. Engenheiro Francisco José Longo, 777, Jardim São Dimas, 12245-000 São José dos Campos, Brazil. Electronic address: anaanbinder@hotmail.com.
authors.forename: Ana Lia
authors.initials: AL
authors.lastname: Anbinder
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000503:physiopathology*; D016723:Bone Remodeling; D005260:Female; D008334:Mandible / Q000503:physiopathology*; D008437:Maxilla / Q000503:physiopathology*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000503:physiopathology*
keywords: Bone resorption; Jaw; Osteoporosis; Ovariectomy; Tibia