title: Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis.
abstract: BACKGROUND
  Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll-like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy.
  
  
  METHODS
  We analyzed the role of functional single-nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow-band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis.
  
  
  RESULTS
  We found a significant relationship between TLR9-1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution.
  
  
  CONCLUSIONS
  We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.
authors.affiliation: Department of Dermatology, Consorci Sanitari Parc Taulí, Autonomous University of Barcelona, Sabadell, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Romaní
authors.forename: Marc
authors.initials: M
authors.lastname: Julià
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
authors.forename: Carlos
authors.initials: C
authors.lastname: Muñoz-Santos
authors.forename: Antonio
authors.initials: A
authors.lastname: Guilabert
authors.forename: José M
authors.initials: JM
authors.lastname: Carrascosa
authors.forename: Mercedes
authors.initials: M
authors.lastname: Rigla
authors.forename: Jesús
authors.initials: J
authors.lastname: Luelmo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics* / Q000532:radiotherapy*; D012720:Severity of Illness Index; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D014467:Ultraviolet Therapy
chemical_list: C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9
keywords: UVB; phototherapy; psoriasis; toll-like receptor