title: An update on 2,5-diketopiperazines from marine organisms.
abstract: 2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. prsxs@bath.ac.uk.
authors.forename: Ri-Ming
authors.initials: RM
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xiangxiyi81@aliyun.com.
authors.forename: Xiang-Xi
authors.initials: XX
authors.lastname: Yi
authors.affiliation: Department of Cell Biology, Jinan University, Guangzhou 510632, China. chenlu0268@163.com.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. prsxs@bath.ac.uk.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Su
authors.affiliation: Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China. py00_2006@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. gaochenghai@gxas.cn.
authors.forename: Cheng-Hai
authors.initials: CH
authors.lastname: Gao
mesh_terms: D059001:Aquatic Organisms / Q000737:chemistry* / Q000378:metabolism*; D054659:Diketopiperazines / Q000737:chemistry* / Q000378:metabolism*; D004151:Dipeptides / Q000096:biosynthesis* / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008386:Marine Biology
chemical_list: D054659:Diketopiperazines; D004151:Dipeptides