title: Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model.
abstract: X-linked Hypohidrotic Ectodermal Dysplasia (XLHED) is associated to a large spectrum of ectodermal and extra-ectodermal symptoms, especially craniofacial bone morphological, structural and metabolic anomalies. This skeletal phenotype described in affected patients and in the Ta mutant mouse model leads to craniofacial dysmorphies, endosseous implants and jaw bone grafts complications. Bone tissue bioengineering based on the use of PCL synthetic nanofibrous membrane and BMP nanoreservoirs appears as an original and promising approach to prevent such complications in the context of dysfunctional bone. Use of osteoblasts or stem cells seeded biomembranes appears as another strategy developed on the Tabby (Ta) model of XLHED. The Ta mouse experimental model is used to study the jaw bone response during the post-operative period after bone lesion and placement of synthetic PCL membrane functionalized with nanoreservoirs embedding different BMPs dimers or seeded with living cells.
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Noordijk
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Davideau
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France.
authors.forename: Sandy
authors.initials: S
authors.lastname: Eap
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Huck
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Fioretti
authors.affiliation: Unité de Thérapie Cellulaire et Tissus, CHU Brabois, Nancy, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Stoltz
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: William
authors.initials: W
authors.lastname: Bacon
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Benkirane-Jessel
authors.affiliation: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France.
authors.forename: François
authors.initials: F
authors.lastname: Clauss
mesh_terms: D000818:Animals; D001848:Bone Diseases, Developmental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D001861:Bone Regeneration / Q000502:physiology*; D004195:Disease Models, Animal; D053358:Ectodermal Dysplasia 1, Anhidrotic / Q000473:pathology / Q000628:therapy*; D053331:Ectodysplasins / Q000235:genetics; D005544:Forecasting; D051379:Mice; D009154:Mutation / Q000235:genetics; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends
chemical_list: D053331:Ectodysplasins; C506019:Eda protein, mouse
keywords: Ectodermal dysplasia; bone regeneration; tissue engineering