title: Effect of piperine, a major component of black pepper, on the pharmacokinetics of domperidone in rats.
abstract: The present study was aimed to investigate the effect of piperine, a major active ingredient of black pepper, on the pharmacokinetics of domperidone in rats. Animals were given oral (p.o.) or intraperitoneal (i.p.) domperidone (20 mg/kg) alone or together with piperine (20 mg/kg, p.o.). Plasma samples were collected at 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0 and 12 hours after drug administration. The concentration of domperidone in the plasma was measured using a HPLC method. The concomitant administration of piperine with oral or intraperitoneal domperidone resulted in a significant (P<0.05) increase in the maximum plasma concentration (Cmax), the mean area under the plasma concentration-time curve (AUC), and the elimination half-life (t1/2) of domperidone as compared to those obtained for domperidone alone. These results suggest that an important pharmacokinetic interaction may occur if piperine is administered concurrently with domperidone.
authors.affiliation: Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia. humayyd@yahoo.com.
authors.forename: M S
authors.initials: MS
authors.lastname: Alhumayyd
authors.forename: I A
authors.initials: IA
authors.lastname: Bukhari
authors.forename: A A
authors.initials: AA
authors.lastname: Almotrefi
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D052117:Benzodioxoles / Q000494:pharmacology*; D004294:Domperidone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D029222:Piper nigrum; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D017208:Rats, Wistar
chemical_list: D000470:Alkaloids; D000932:Antiemetics; D052117:Benzodioxoles; D018492:Dopamine Antagonists; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D004294:Domperidone; C008922:piperine