title: Bioinspired formation of 3D hierarchical CoFe2O4 porous microspheres for magnetic-controlled drug release.
abstract: Bioinspired by the morphology of dandelion pollen grains, we successfully prepared a template-free solution-based method for the large-scale preparation of three-dimensional (3D) hierarchical CoFe2O4 porous microspheres. Besides, on the basis of the effect of the reaction time on the morphology evolution of the precursor, we proposed an in situ dissolution-recrystallization growth mechanism with morphology and phase change to understand the formation of dandelion pollenlike microspheres. Doxorubicin hydrochloride, an anticancer drug, is efficiently loaded into the CoFe2O4 microspheres. The magnetic nanoparticles as field-controlled drug carriers offer a unique power of magnetic guidance and field-triggered drug-release behavior. Therefore, 3D hierarchical CoFe2O4 porous microspheres demonstrate the great potential for drug encapsulation and controlled drug-release applications.
authors.affiliation: Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, and ‡Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University , Hangzhou 310027, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Minggang
authors.initials: M
authors.lastname: Zhao
authors.forename: Ye
authors.initials: Y
authors.lastname: Ma
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Ye
authors.forename: Jingyun
authors.initials: J
authors.lastname: Huang
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D065546:Drug Liberation; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008863:Microspheres; D011058:Pollen / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D016062:Porosity
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D011108:Polymers
keywords: CoFe2O4; bioinspired; controlled release; microsphere