title: Intrathoracic splenosis: a rare false-positive cause of somatostatin imaging in characterization of solitary pulmonary nodule.
abstract: Scanning using a somatostatin receptor analog such as Tc-EDDA/HYNIC-TOC has sensitivity and specificity similar to those of FDG-PET, which has high accuracy in the characterization of a solitary pulmonary nodule (SPN). We describe a 63-year-old man with well-defined SPN in the left lung on chest x-ray and CT scan. Whole-body scanning and chest SPECT were performed with Tc-EDDA/HYNIC-TOC for the characterization of SPN. Abnormal focal increased radiotracer uptake in the left hemithorax was detected. In addition, no spleen activity was observed in the anatomical location. Cytopathologic evaluation of SPN revealed splenosis.
authors.affiliation: From *Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine; †Department of Radiology, Faculty of Medicine; and ‡Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Mahmoudian
authors.forename: Reza
authors.initials: R
authors.lastname: Javadrashid
authors.forename: Ashraf
authors.initials: A
authors.lastname: Fakhrjoo
mesh_terms: D003937:Diagnosis, Differential; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005189:False Positive Reactions; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D017890:Splenosis / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C031123:technetium Tc 99m ethylenediamine-N,N-diacetic acid; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D004492:Edetic Acid; D015282:Octreotide