title: AATF RNome has the potential to define post mortem interval.
abstract: Keeping in view the fact that the circadian rhythm governs human behavioral characteristics, metabolism and body function, the present study was directed to explore whether or not there exists any cooperativity between AATF RNome (comprising AATF mRNA and its encoded microRNA miR-2909) rhythmicity and post mortem interval (PMI). Such a study unambiguously revealed that circadian rhythm exhibited by AATF RNome has a direct correlation with PMI in Balb/c mice. AATF RNome has the potential to act as biomarker for PMI with reasonably good accuracy and hence may turn out to be of crucial importance in forensic investigation.
authors.affiliation: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India; Department of Forensic Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Forensic Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: Dalbir
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. Electronic address: dkaul_24@hotmail.com.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaul
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002909:Chronobiology Phenomena; D053803:Forensic Genetics; D005819:Genetic Markers; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics*; D011180:Postmortem Changes; D012333:RNA, Messenger / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C523104:Aatf protein, rat; D005819:Genetic Markers; D035683:MicroRNAs; D009687:Nuclear Proteins; D012333:RNA, Messenger; D014157:Transcription Factors
keywords: AATF RNome; Circadian pacemaker; Expressional stability; PMI