title: Androgen receptor in human endothelial cells.
abstract: Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
authors.forename: Verónica
authors.initials: V
authors.lastname: Torres-Estay
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Carreño
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
authors.forename: Ignacio F
authors.initials: IF
authors.lastname: San Francisco
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Sotomayor
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA Gary.Smith@RoswellPark.org Alejandro.Godoy@RoswellPark.org.
authors.forename: Alejandro S
authors.initials: AS
authors.lastname: Godoy
authors.affiliation: Departamento de FisiologíaUrologíaPontificia Universidad Católica de Chile, Santiago de Chile, ChileCenter for Integrative Medicine and Innovative SciencesUniversidad Andrés Bello, Santiago de Chile, ChileDepartment of UrologyRoswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA Gary.Smith@RoswellPark.org Alejandro.Godoy@RoswellPark.org.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Smith
mesh_terms: D066026:Endothelial Progenitor Cells / Q000502:physiology; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism*
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen
keywords: androgen receptor; angiogenesis; cancer; endothelium