title: Theranostic magnetoliposomes coated by carboxymethyl dextran with controlled release by low-frequency alternating magnetic field.
abstract: The aim of this work was to construct carboxymethyl dextran (CMD)-coated magnetoliposomes (MLs), another stealth MLs alternative to PEGylated MLs, for theranostic application. Particularly, the on-demand release of CMD-MLs under low-frequency alternating magnetic field (LF-AMF) was studied. We found that as-prepared MLs exhibited good stability and high drug loading ability for doxorubicin (DOX). Cytotoxicity assay against human neuroblastoma SH-SY5Y cells showed that the DOX-loaded CMD-MLs were less toxic than free DOX due to the sustained release of DOX. However, the release of DOX-loaded CMD-MLs was enhanced by low-frequency alternating magnetic field without hyperthermia generation. The MLs also acted as an efficient T2-weighted contrast agent during in vitro MRI measurements. The above results provide useful information on in vivo diagnostic/therapeutic efficacy of DOX-loaded CMD-MLs for some cancers, such as brain cancers.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Guo
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China.
authors.forename: Wansong
authors.initials: W
authors.lastname: Chen
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China.
authors.forename: You-Nian
authors.initials: YN
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China. Electronic address: juanli@csu.edu.cn.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road, Changsha 410083, Hunan, PR China. Electronic address: jxiuwang@csu.edu.cn.
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Wang
mesh_terms: D003911:Dextrans / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging
chemical_list: D003911:Dextrans; D008081:Liposomes; D004317:Doxorubicin; C014392:carboxymethyl dextran
keywords: Carboxymethyl dextran; Controlled release; Doxorubicin; Liposome; Magnetic resonance imaging