title: Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report.
abstract: Leiomyomatosis peritonealis disseminata is a very rare, benign entity of unknown pathogenesis, characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules throughout the peritoneal surface. Mostly the course is asymptomatic and it is found incidentally during laparotomy, laparoscopy or cesarean section. Non-specific symptoms such as abdominal pain, vaginal bleeding, abdominal mass or gastrointestinal signs are described. Rare cases of malignant transformation have been reported. We present a case of disseminated peritoneal leiomyomatosis with an unusual course and transformation to endometrial sarcoma in a 26-year-old previously healthy woman, where the appearance of peritoneal nodules was preceded by multiple incidents of fast fibroid growth and delivery of myomatous growth into the cervical canal.
authors.affiliation: Department of Gynecology and Oncological Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: Monika M
authors.initials: MM
authors.lastname: Żyła
authors.forename: Monika
authors.initials: M
authors.lastname: Dzieniecka
authors.forename: Marta
authors.initials: M
authors.lastname: Kostrzewa
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stetkiewicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wilamowska
authors.forename: Kinga
authors.initials: K
authors.lastname: Księżakowska-Łakoma
authors.forename: Jacek R
authors.initials: JR
authors.lastname: Wilczyński
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000473:pathology; D009130:Muscle, Smooth / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000473:pathology*; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012509:Sarcoma / Q000453:epidemiology*; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Endometrial sarcoma; leiomyoma; leiomyomatosis peritonealis disseminata; leiomyosarcoma; malignant transformation