title: Prostatic artery embolization for treatment of benign prostatic hyperplasia in patients with prostates > 90 g: a prospective single-center study.
abstract: OBJECTIVE
  To describe the safety and efficacy of prostatic artery embolization (PAE) with spherical microparticles to treat lower urinary tract symptoms associated with benign prostatic hyperplasia in patients with prostate volume > 90 g.
  
  
  METHODS
  This prospective, single-center, single-arm study was conducted in 35 patients with prostate volumes ranging from 90-252 g. Mean patient age was 64.8 years (range, 53-77 y). Magnetic resonance imaging, uroflowmetry, and the International Prostate Symptom Score (IPSS) were used to assess clinical and functional outcomes.
  
  
  RESULTS
  Mean prostate size decreased significantly from 135.1 g before PAE to 91.9 g at 3 months of follow-up (P < .0001). Mean IPSS and quality-of-life index improved from 18.3 to 2.7 and 4.8 to 0.9 (P < .0001 for both), respectively. A significant negative correlation was observed between prostate-specific antigen at 24 hours after PAE and IPSS 3 months after PAE (P = .0057).
  
  
  CONCLUSIONS
  PAE is a safe and effective treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia in patients with prostate volume > 90 g. Excessively elevated prostate-specific antigen within 24 hours of PAE is associated with lower symptom burden in short-term follow-up.
authors.affiliation: Interventional Radiology and Endovascular Surgery Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil. Electronic address: andre.maa@gmail.com.
authors.forename: André Moreira
authors.initials: AM
authors.lastname: de Assis
authors.affiliation: Interventional Radiology and Endovascular Surgery Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Airton Mota
authors.initials: AM
authors.lastname: Moreira
authors.affiliation: Interventional Radiology and Endovascular Surgery Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Vanessa Cristina
authors.initials: VC
authors.lastname: de Paula Rodrigues
authors.affiliation: Radiology Institute, and Urology Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Eduardo Muracca
authors.initials: EM
authors.lastname: Yoshinaga
authors.affiliation: Radiology Institute, and Urology Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Alberto Azoubel
authors.initials: AA
authors.lastname: Antunes
authors.affiliation: The Dartmouth Center for Health Care Delivery Science, Hanover, New Hampshire.
authors.forename: Sardis Honoria
authors.initials: SH
authors.lastname: Harward
authors.affiliation: Radiology Institute, and Urology Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
authors.affiliation: Interventional Radiology and Endovascular Surgery Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil.
authors.forename: Francisco Cesar
authors.initials: FC
authors.lastname: Carnevale
mesh_terms: D000368:Aged; D004621:Embolization, Therapeutic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000098:blood supply*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen