title: Impact of neurological impairment, depression, cognitive function and coping on quality of life of people with multiple sclerosis: A relative importance analysis.
abstract: BACKGROUND
  Determining the relative importance of factors that predict quality of life (QoL) in people with multiple sclerosis (MS) must be addressed through multiple regression metrics, e.g. relative weights, which are designed to solve colinearity problems.
  
  
  OBJECTIVE
  We aimed to compare disease variables, Expanded Disability Status Scale (EDSS), depressive symptomatology (BDI-FS), cognitive performance and coping in predicting MS patients' QoL, using relative weights.
  
  
  METHODS
  We assessed 97 patients with MS, using the Functional Assessment of MS (FAMS) as the criterion.
  
  
  RESULTS
  EDSS predicted global and physical QoL domains, whereas BDI-FS predicted general contentment and global QoL.
  
  
  CONCLUSIONS
  EDSS and BDI-FS are relevant determinants of QoL in people with MS.
authors.affiliation: Department of Personality, Assessment and Psychological Treatment; University of Seville; Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernández-Jiménez
authors.affiliation: Department of Psychology; Pennsylvania State University, University Park, PA, USA paa6@psu.edu.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Arnett
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index
keywords: Cognitive function; Expanded Disability Status Scale; coping; depression; multiple sclerosis; predictive model; quality of life measures; relative importance; relative weight