title: Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency.
abstract: The berries of bilberry and black currant are a rich source of anthocyanins, which are thought to have favorable effects on nonalcoholic steatohepatitis (NASH). This study was designed to examine whether purified anthocyanins from bilberry and black currant are able to limit the disorders related to NASH induced by a methionine-choline-deficient (MCD) diet in mice. The results showed that treatment with anthocyanins not only alleviated inflammation, oxidative stress, steatosis, and even fibrosis but also improved depletion of mitochondrial content and damage of mitochondrial biogenesis and electron transfer chain developed concomitantly in the liver of mice fed the MCD diet. Furthermore, anthocyanins treatment promoted activation of AMP-activated protein kinase (AMPK) and expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α). These data provide evidence that anthocyanins possess significant protective effects against NASH and mitochondrial defects in response to a MCD diet, with a mechanism maybe through affecting the AMPK/PGC-1α signaling pathways.
authors.affiliation: Department of Nutrition, School of Public Health, Sun Yat-Sen University , Guangzhou 510080, P. R. China.
authors.forename: Xilan
authors.initials: X
authors.lastname: Tang
authors.forename: Tianran
authors.initials: T
authors.lastname: Shen
authors.forename: Xinwei
authors.initials: X
authors.lastname: Jiang
authors.forename: Min
authors.initials: M
authors.lastname: Xia
authors.forename: Xujia
authors.initials: X
authors.lastname: Sun
authors.forename: Honghui
authors.initials: H
authors.lastname: Guo
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000302:isolation & purification; D002796:Choline Deficiency / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D005234:Fatty Liver / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000172:deficiency*; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D031965:Ribes / Q000737:chemistry*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D029800:Vaccinium myrtillus / Q000737:chemistry*
chemical_list: D000872:Anthocyanins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010936:Plant Extracts; C485290:Ppargc1a protein, mouse; D014157:Transcription Factors; D008715:Methionine; D055372:AMP-Activated Protein Kinases
keywords: AMP-activated protein kinase; anthocyanin; mitochondrial dysfunction; nonalcoholic fatty liver disease; oxidative stress