title: Dysfunctional action control as a specific feature of Parkinson's disease.
abstract: Parkinson's disease (PD) is characterised by motor deficits as well as cognitive alterations, particularly concerning frontal lobe control. Here, we were interested in whether executive function is abnormal already early in PD, as well as whether this dysfunction worsens as a part of the dementia in PD. The following groups engaged in tasks addressing action control: PD patients with mild and advanced motor symptoms (aPD) without dementia, PD patients with dementia (PDD), patients with Alzheimer's disease (AD) and healthy subjects (CON). Subjects either had to perform or inhibit button presses upon go and no-go cues, respectively. These cues were preceded by pre-cues, either randomly instructive of right or left hand preparation (switch condition), or repetitively instructive for one side only (non-switch condition). PDD and aPD omitted more go responses than CON. Furthermore, PDD disproportionally committed failures upon no-go cues compared to CON. In the non-switch condition, PDD performed worse than AD, whose deficits increased to the level of PDD in the switch condition. Over all PD patients, task performance correlated with disease severity. Under the switch condition, task performance was low in both PDD and AD. In the non-switch condition, this also held true for advanced PD patients (with and without dementia), but not for AD. Thus, the deficits evident in PDD appear to develop from imbalanced inhibitory-to-excitatory action control generally inherent to PD. These results specify the concept of dysexecution in PD and differentiate the cognitive profile of PDD from that of AD patients.
authors.affiliation: Charité, University Medicine Berlin, Berlin, Germany, frank.marzinzik@charite.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Marzinzik
authors.forename: Anja
authors.initials: A
authors.lastname: Herrmann
authors.forename: Jacob H
authors.initials: JH
authors.lastname: Gogarten
authors.forename: Andreas
authors.initials: A
authors.lastname: Lueschow
authors.forename: Joachim E
authors.initials: JE
authors.lastname: Weber
authors.forename: Katharina A
authors.initials: KA
authors.lastname: Schindlbeck
authors.forename: Fabian
authors.initials: F
authors.lastname: Klostermann
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D010775:Photic Stimulation; D011597:Psychomotor Performance; D011930:Reaction Time; D012720:Severity of Illness Index