title: Correlation of ischemia-modified albumin with SOFA and APACHE II scores in preoperative patients with colorectal cancer.
abstract: OBJECTIVE
  Critical illnesses are assessed according to the sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II. Circulating ischemia-modified albumin (IMA) is a biomarker generated under ischemic and oxidative conditions and may reflect disease severity in preoperative patients. This study investigated the correlations of IMA with SOFA and APACHE II scores in inpatients admitted for colorectal surgery.
  
  
  METHODS
  We examined 27 patients with advanced colorectal cancers (mean age 69 years, men/women=15/12). Correlations between SOFA and APACHE II scores in addition to preoperative serum IMA and C-reactive protein (CRP) levels were analyzed.
  
  
  RESULTS
  The mean IMA level was 0.5 AU, and the median CRP level was 0.6 mg/dL. Median scores for SOFA and APACHE II were 2 and 12 points, respectively. Significant positive correlations between IMA and SOFA (r=0.45, P<0.05) and IMA and APACHE II (r=0.45, P<0.05) were identified which remained significant in confounder-adjusted analyses. In contrast, weak correlations were observed between CRP and the SOFA and APACHE II scores.
  
  
  CONCLUSIONS
  The positive correlations between IMA and both SOFA and APACHE II scores suggest that serum IMA measurements reflect the severity of systemic failure in patients admitted for colorectal surgery in the preoperative phase.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Satoh
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan ; Glycation, Oxidation and Disease Laboratory, Touro University California, 1310 Club Dr, Vallejo, CA 94594, USA.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.affiliation: Glycation, Oxidation and Disease Laboratory, Touro University California, 1310 Club Dr, Vallejo, CA 94594, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gugliucci
authors.affiliation: Department of General Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
authors.forename: Hisanaga
authors.initials: H
authors.lastname: Horie
authors.affiliation: Glycation, Oxidation and Disease Laboratory, Touro University California, 1310 Club Dr, Vallejo, CA 94594, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Caccavello
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Takeuchi
mesh_terms: D018806:APACHE; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D063305:Organ Dysfunction Scores; D011300:Preoperative Care; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human