title: Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
abstract: OBJECTIVE
  The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.
  
  
  METHODS
  Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion-detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion-detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl.
  
  
  RESULTS
  Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group.
  
  
  CONCLUSIONS
  Our study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, Turkey.
authors.forename: Raziye
authors.initials: R
authors.lastname: Keskin Kurt
authors.affiliation: Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Ayşe Citil
authors.initials: AC
authors.lastname: Dogan
authors.affiliation: Department of Physiology, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dogan
authors.affiliation: Departments of Pathology, Ankara Diskapi YB Training and Research Hospital, Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Albayrak
authors.affiliation: Department of Physiology, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: Sefika Nur
authors.initials: SN
authors.lastname: Kurt
authors.affiliation: Department of Physiology, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: Furkan
authors.initials: F
authors.lastname: Eren
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, Turkey.
authors.forename: Dilek Benk
authors.initials: DB
authors.lastname: Silfeler
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Karateke
authors.affiliation: Department of Physiology, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Fadillioglu
authors.affiliation: Endocrinology and Metabolism, Ankara Diskapi YB Training and Research Hospital, Ankara, Turkey.|Pancreas Islet Research Center, Ankara Diskapi YB Training and Research Hospital, Ankara, Turkey.|Department of Endocrinology and Metabolism, Hacettepe University Kastamonu Medical School, Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D002216:Captopril / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002374:Catalase / Q000037:antagonists & inhibitors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000378:metabolism; D010049:Ovarian Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D010053:Ovary / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D011897:Random Allocation; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D054159:Torsion, Mechanical
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D015415:Biomarkers; C044958:zofenopril; D008315:Malondialdehyde; D002216:Captopril; D002374:Catalase
keywords: antioxidant; ischemia-reperfusion injury; ovarian torsion; zofenopril