title: Markers of endothelial function in migraine patients: Results from a bi-center prospective study.
abstract: BACKGROUND
  Numerous studies suggest an increased vascular risk in patients with migraine, in particular in those with aura. A possible link between both conditions might be a dysfunction of the vascular endothelium. This observational study analyzed the endothelial markers angiopoietin-1, angiopoietin-2, Tie-2, sFlt-1 and NT-proBNP for the first time in migraineurs, patients with other primary headache disorders and healthy controls.
  
  
  METHODS
  Patients with episodic migraine with and without aura, episodic cluster headache, tension-type headache and healthy controls were included. Blood samples were obtained during migraine attacks and headache-free periods in migraineurs, in and out of bout in cluster headache and during headache-free periods in tension-type headache and healthy individuals to analyze markers of endothelial function.
  
  
  RESULTS
  No significant difference in endothelial markers between migraine, other headache disorders and healthy controls was detected. There was no significant difference between migraine attacks and headache-free intervals. Additionally, no distinction could be found between migraine with and without aura.
  
  
  CONCLUSIONS
  The endothelial markers analyzed do not display a characteristic pattern in different headache disorders especially migraine compared to healthy controls. The novel findings of our study indicate that factors other than endothelial dysfunction seem to be responsible for the at least statistical association of migraine with vascular disease.
authors.affiliation: Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Austria.
authors.forename: Marlene
authors.initials: M
authors.lastname: Fischer
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany Migräne und Kopfschmerzklinik Königstein, Germany.
authors.forename: Charly
authors.initials: C
authors.lastname: Gaul
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Hind
authors.initials: H
authors.lastname: Shanib
authors.affiliation: Department of Neurology, University of Duisburg-Essen, Germany.
authors.forename: Dagny
authors.initials: D
authors.lastname: Holle
authors.affiliation: Central Institute of Medicinal and Chemical Laboratory Diagnostics, University Hospital, Austria.
authors.forename: Lorin
authors.initials: L
authors.lastname: Loacker
authors.affiliation: Central Institute of Medicinal and Chemical Laboratory Diagnostics, University Hospital, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Griesmacher
authors.affiliation: Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Lackner
authors.affiliation: Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Austria gregor.broessner@i-med.ac.at.
authors.forename: Gregor
authors.initials: G
authors.lastname: Broessner
mesh_terms: D000328:Adult; D042683:Angiopoietin-1 / Q000097:blood; D042702:Angiopoietin-2 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D042787:Receptor, TIE-2 / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: C467630:ANGPT1 protein, human; C586513:ANGPT2 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C501162:FLT1 protein, human; D042787:Receptor, TIE-2; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Migraine; angiopoietin; disease; endothelial dysfunction; vascular