title: Differences in the prognostic significance of the SUVmax between patients with resected pulmonary Adenocarcinoma and squamous cell carcinoma.
abstract: BACKGROUND
  The purpose of this study was to determine the prognostic significance of the maximum standardized uptake value (SUVmax) on F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients undergoing surgical treatment for non-small cell lung cancer.
  
  
  METHODS
  Seventy-eight consecutive patients (58 with adenocarcinomas, 20 with squamous cell carcinomas) treated with potentially curative surgery were retrospectively reviewed.
  
  
  RESULTS
  The SUVmax was significantly higher in the patients with recurrent than with non-recurrent adenocarcinoma (p<0.01). However, among the patients with squamous cell carcinoma, there were no differences with or without recurrence (p=0.69). Multivariate analysis indicated that the SUVmax of adenocarcinoma lesions was a significant predictor of disease-free survival (p=0.04). In addition, an SUVmax of 6.19, the cut-off point based on ROC curve analysis of the patients with pathological IB or more advanced stage adenocarcinomas, was found to be a significant predictor of disease-free survival (p<0.01).
  
  
  CONCLUSIONS
  SUVmax is a useful predictor of disease-free survival in patients with resected adenocarcinoma, but not squamous cell carcinoma. Patients with adenocarcinoma exhibiting an SUVmax above 6.19 are candidates for more intensive adjuvant therapy.
authors.affiliation: Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan E-mail : motono@kanazawa-med.ac.jp; sagawam@kanazawa-med.ac.jp.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Motono
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ueno
authors.forename: Makoto
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Machida
authors.forename: Katsuo
authors.initials: K
authors.lastname: Usuda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sakuma
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Sagawa
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D011379:Prognosis; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18