title: Prevalence of parathyroid carcinoma in 348 patients with multiple endocrine neoplasia type 1 - case report and review of the literature.
abstract: OBJECTIVE
  To report the prevalence of parathyroid carcinoma (PC) in patients with multiple endocrine neoplasia type 1 (MEN1) and review of the literature.
  
  
  BACKGROUND
  Primary hyperparathyroidism (PHP) is the most common manifestation of MEN1. The occurrence of PC in patients with MEN1 is rare and the literature regarding the clinical manifestations - including the prevalence of the disease - is scarce.
  
  
  BACKGROUND
  Single tertiary care centre experience from 1977 to 2013.
  
  
  METHODS
  Electronic search of the medical records to identify a cohort of patients with MEN1. Literature review based on current case reports.
  
  
  METHODS
  Single case of PC in a cohort of 348 patients with MEN1. Ten cases of PC in patients with MEN1 reported in the literature.
  
  
  METHODS
  Clinical features of PC in patients with MEN1.
  
  
  RESULTS
  The prevalence of PC in 348 patients with MEN1 was found to be 0·28% (95% CI, 0-1·4%). Based on the current published cases of PC in patients with MEN1, 54·5% were women, mean age at diagnosis was 48·3 years, and the serum PTH concentrations at least four times the upper limit of the reference range in 73% of the cases.
  
  
  CONCLUSIONS
  PC in patients with MEN 1 is rare with a prevalence of 0·28%, and the clinical features are similar to PC in patients without MEN1.
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Naykky
authors.initials: N
authors.lastname: Singh Ospina
authors.affiliation: Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Sebo
authors.affiliation: Section of Endocrine Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Geoffrey B
authors.initials: GB
authors.lastname: Thompson
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Bart L
authors.initials: BL
authors.lastname: Clarke
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: William F
authors.initials: WF
authors.lastname: Young