title: North vs south differences in acute peptic ulcer hemorrhage in Croatia: hospitalization incidence trends, clinical features, and 30-day case fatality.
abstract: OBJECTIVE
  To assess the seven-year trends of hospitalization incidence due to acute peptic ulcer hemorrhage (APUH) and associated risk factors, and examine the differences in these trends between two regions in Croatia.
  
  
  METHODS
  The study collected sociodemographic, clinical, and endoscopic data on 2204 patients with endoscopically confirmed APUH who were admitted to the Clinical Hospital Center "Sestre Milosrdnice," Zagreb and Clinical Hospital Center Split between January 1, 2005 and December 31, 2011. We determined hospitalization incidence rates, 30-day case fatality rate, clinical outcomes, and incidence-associated factors.
  
  
  RESULTS
  No differences were observed in APUH hospitalization incidence rates between the regions. Age-standardized one-year cumulative APUH hospitalization incidence rate calculated using the European Standard Population was significantly higher in Zagreb than in Split region (43.2/100 000 vs 29.2/100,000). A significantly higher APUH hospitalization incidence rates were observed in the above 65 years age group. Overall 30-day case fatality rate was 4.9%.
  
  
  CONCLUSIONS
  The hospitalization incidence of APUH in two populations did not change over the observational period and it was significantly higher in the Zagreb region. The incidence of acute duodenal ulcer hemorrhage also remained unchanged, whereas the incidence of acute gastric ulcer hemorrhage increased. The results of this study allow us to monitor epidemiological indicators of APUH and compare data with other countries.
authors.affiliation: Neven Ljubičić, Department of Internal Medicine, "Sestre Milosrdnice" Clinical Hospital Center, University of Zagreb School of Medicine and School of Dental Medicine, Vinogradska 29, Zagreb 10000, Croatia, neven.ljubicic@kbcsm.hr.
authors.forename: Neven
authors.initials: N
authors.lastname: Ljubičić
authors.forename: Tajana
authors.initials: T
authors.lastname: Pavić
authors.forename: Ivan
authors.initials: I
authors.lastname: Budimir
authors.forename: Željko
authors.initials: Ž
authors.lastname: Puljiz
authors.forename: Alen
authors.initials: A
authors.lastname: Bišćanin
authors.forename: Andre
authors.initials: A
authors.lastname: Bratanić
authors.forename: Marko
authors.initials: M
authors.lastname: Nikolić
authors.forename: Davor
authors.initials: D
authors.lastname: Hrabar
authors.forename: Branko
authors.initials: B
authors.lastname: Troskot
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000208:Acute Disease; D000284:Administration, Oral; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D017523:Croatia / Q000453:epidemiology; D004837:Epinephrine / Q000008:administration & dosage; D064098:Esomeprazole / Q000627:therapeutic use; D005260:Female; D005843:Geography; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D000077402:Pantoprazole; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D012307:Risk Factors; D017678:Sex Distribution; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D014662:Vasoconstrictor Agents; D000077402:Pantoprazole; D064098:Esomeprazole; D004837:Epinephrine