title: IncobotulinumtoxinA for the treatment of platysmal bands: a single-arm, prospective proof-of-concept clinical study.
abstract: BACKGROUND
  IncobotulinumtoxinA improves the appearance of facial rhytides and the aging neck.
  
  
  OBJECTIVE
  To investigate the efficacy, safety, and subject satisfaction of incobotulinumtoxinA for platysmal band treatment.
  
  
  METHODS
  Subjects (n = 23) with 2 to 4 platysmal bands (scoring ≥1 on a newly validated 5-point assessment scale) were enrolled. IncobotulinumtoxinA (15 U) was administered to each band. Assessments, using the 5-point scale, occurred at 6 posttreatment visits over 5 months. Adverse events were recorded and subjects self-assessed the appearance of their platysmal bands versus baseline.
  
  
  RESULTS
  At maximum tension, a response (≥1-point improvement from baseline score) was observed in 65.2% of subjects 3 (±1) days posttreatment, rising to 100% on Day 8 (±1). The change from baseline in the mean score was significant at each time point, including the final visit (Weeks 20-21). Response rates were higher at maximum tension than at rest. The peak effect occurred later at rest than at maximum tension. No serious adverse event occurred. At maximum tension, 69.6%, 73.9%, and 68.2% of subjects rated their platysmal bands as "improved" or "markedly improved" at Visits 2, 3, and 4, respectively.
  
  
  CONCLUSIONS
  IncobotulinumtoxinA is an effective and well-tolerated treatment for platysmal bands, with a rapid onset and long duration of effect.
authors.affiliation: *Prager and Partner, Derma-Hamburg, Hamburg, Germany; †Praxis für Dermatologie, Hautarztpraxis Stengel and Bee, Munster, Germany; ‡SCIderm GmbH, Hamburg, Germany.
authors.forename: Welf
authors.initials: W
authors.lastname: Prager
authors.forename: Eva K
authors.initials: EK
authors.lastname: Bee
authors.forename: Isabel
authors.initials: I
authors.lastname: Havermann
authors.forename: Ina
authors.initials: I
authors.lastname: Zschocke
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D003357:Cosmetic Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA