title: TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.
abstract: The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFNγ) in the development of autoimmunity. We will also review recent data indicating how these factors may affect an immune response in a gender-dependent manner.
authors.affiliation: Howard Hughes Medical Institute, Denver, CO 80206, USA; Department of Biomedical Science, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, CO 80206, USA. Electronic address: rubtsovak@njhealth.org.
authors.forename: Kira
authors.initials: K
authors.lastname: Rubtsova
authors.affiliation: Howard Hughes Medical Institute, Denver, CO 80206, USA; Department of Biomedical Science, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, CO 80206, USA; Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.
authors.forename: Philippa
authors.initials: P
authors.lastname: Marrack
authors.affiliation: Howard Hughes Medical Institute, Denver, CO 80206, USA; Department of Biomedical Science, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, CO 80206, USA.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Rubtsov
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D039521:CD11c Antigen / Q000096:biosynthesis; D005260:Female; D018628:Gene Dosage / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D051379:Mice; D012727:Sex Characteristics; D020825:T-Box Domain Proteins / Q000235:genetics*; D051199:Toll-Like Receptor 7 / Q000235:genetics*; D000098815:T-bet Transcription Factor
chemical_list: D039521:CD11c Antigen; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7; D007371:Interferon-gamma
keywords: ABCs; Autoimmunity; Gender; IFNgamma; T-bet; TLR7