title: Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer.
abstract: Both benign prostatic hyperplasia (BPH) and prostate cancer (PC) are common diseases for men around the world. Both serine/threonine protein kinase MST4 (MST4) and serine/threonine kinase 25 (STK25) belong to the Ste20-like kinases and interact with programmed cell death 10 (PDCD10) which is closely linked to cancer diseases. To clarify the roles of MST4, STK25 and PDCD10 in prostate carcinogenesis, we examined MST4, STK25 and PDCD10 expression in tissue microarray blocks containing 110 cores of BPH and 160 cores of PC immunohistochemically and evaluated their correlation with clinicopathological findings. MST4 was not expressed in all the BPH cases and expressed in 38.7% of PC cases (P < 0.0001). STK25 expression was found in 77.3% of BPH cases and 93.1% of PC cases (P < 0.0001). PDCD10 staining was considered weak in 82 (74.5%) and strong in 28 (25.5%) of BPH cases. However, in prostate cancer cases, PDCD10 staining was weak in 95 (59.4%) and strong in 65 (40.6%) (P < 0.05). PDCD10 and STK25 immunostaining were associated with age in prostatic hyperplasia cases (P < 0.05). The staining intensity for STK25 was significantly greater in Gleason grades 3-5 (47.1% of such cases staining strongly) compared with other grades of prostate cancer (only 26.5% of these cases staining strongly; P < 0.05). Our results suggest that MST4, STK25 and PDCD10 are unregulated in prostate cancer and may play roles in prostate tumorigenesis. MST4 may be a helpful marker for identifying prostate cancer.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University No. 38 Xueyuan Road, Beijing, PR China ; Human Disease Genomics Center, Peking University 38 Xueyuan Road, Beijing, PR China ; Central Laboratory, Peking University School of Stomatology 22 South Zhongguancun Road, Beijing, PR China.
authors.forename: Heyu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University 2 Yuanmingyuan West Road, Beijing 100193, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University No. 38 Xueyuan Road, Beijing, PR China ; Human Disease Genomics Center, Peking University 38 Xueyuan Road, Beijing, PR China.
authors.forename: Saihui
authors.initials: S
authors.lastname: Peng
authors.affiliation: Department of Medical Genetics, School of Basic Medical Sciences, Peking University 38 Xueyuan Road, Beijing, PR China ; Human Disease Genomics Center, Peking University 38 Xueyuan Road, Beijing, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Nan
authors.affiliation: Department of Medical Genetics, School of Basic Medical Sciences, Peking University 38 Xueyuan Road, Beijing, PR China ; Human Disease Genomics Center, Peking University 38 Xueyuan Road, Beijing, PR China.
authors.forename: Hongshan
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D003937:Diagnosis, Differential; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015854:Up-Regulation; D055815:Young Adult; D000099317:Hippo Kinases
chemical_list: D051017:Apoptosis Regulatory Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; C495390:PDCD10 protein, human; C430908:STK26 protein, human; D000099317:Hippo Kinases; C530660:STK25 protein, human
keywords: MST4; PDCD10; STK25; benign prostatic hyperplasia; prostate cancer