title: Superficial epithelioma with sebaceous differentiation involving the eyelid: a case report.
abstract: BACKGROUND
  Superficial epithelioma with sebaceous differentiation is a rare benign epithelial neoplasm. It usually involves the head, neck or the back of a middle-age person. To the best of our knowledge, two ocular cases have been reported in the literature.
  
  
  METHODS
  A 46-year-old man of Italian descent, with a known history of testicular seminoma treated by orchiectomy with chemotherapy and radiotherapy, presented with a tan-colored lesion measuring 4mm in diameter in his right upper lid that had been growing over 10 months. It was clinically diagnosed as papilloma. An excisional biopsy was done. On histological examination, the lesion was a well-circumscribed and sharply demarcated epithelial tumor attached to the overlying epidermis and characterized by plate-like proliferation of basaloid to squamous cells with clusters of mature sebaceous cells and foci of ductal differentiation. After a follow-up period of 5 months, no recurrence of the lesion has been documented.
  
  
  CONCLUSIONS
  Superficial epithelioma with sebaceous differentiation is part of the differential diagnoses of eyelid lesions. Arguments in the literature about the correct nomenclature of superficial epithelioma with sebaceous differentiation have resulted in under-diagnosed cases. The benign histological features and the lack of recurrence support its benign nature. Although no clear association has linked superficial epithelioma with sebaceous differentiation with Muir-Torre syndrome, further clinical correlation and close follow up for patients are recommended.
authors.affiliation: Henry C, Witelson Ocular Pathology Laboratory, McGill University, 3775 Rue University, Room 216, Montreal, Quebec, Canada. sultan.aldrees@mail.mcgill.ca.
authors.forename: Sultan S
authors.initials: SS
authors.lastname: Aldrees
authors.forename: Pablo
authors.initials: P
authors.lastname: Zoroquiain
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Logan
authors.forename: Mohammed F
authors.initials: MF
authors.lastname: Qutub
authors.forename: Natalia
authors.initials: N
authors.lastname: Vila
authors.forename: Vasco
authors.initials: V
authors.lastname: Bravo-Filho
authors.forename: Conrad C
authors.initials: CC
authors.lastname: Kavalec
authors.forename: Miguel N
authors.initials: MN
authors.lastname: Burnier
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005143:Eyelids / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000601:surgery; D012627:Sebaceous Glands / Q000473:pathology*