title: Comparing the Healing Effects of Arnebia euchroma Ointment With Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial.
abstract: BACKGROUND
  Arnebia euchroma ointment (AEO) has been used in Iranian traditional medicine for burn wound healing.
  
  
  OBJECTIVE
  The aim of this study is to evaluate wound healing efficacy of AEO in burn wounds after fractional Co2 laser.
  
  
  METHODS
  This split-face, single-blinded, single-center clinical study was performed in Shohada-e-Tajrish Hospital, Tehran, Iran. A total of 26 subjects with facial acne scar, who were to receive fractional CO2 laser resurfacing were recruited. After laser procedure, AEO was applied to one side of the face and petrolatum on the other side for wound healing. Digital photographs were taken from acne scar area before resurfacing and on each of the assessment sessions. Three researchers, who were unaware of the applied medications, assessed these digital photographs for erythema, edema, epithelial confluence, crusting/scabbing, and general wound appearance. Subject's irritations such as dryness and itching were evaluated on the second, fifth, and seventh days.
  
  
  RESULTS
  Our study indicated higher epithelial confluence and general wound appearance scores (P = 0.045 for both) and less erythema and edema on fifth day in petrolatum (P = 0.009 and P = 0.034, respectively). The results showed less crusting and erythema (P = 0.016 and P = 0.035, respectively) and higher general wound appearance scores in petrolatum on the second day (P = 0.035 and P = 0.001, respectively). Dryness was the most common subjective complaint in both groups; however, it was more severe in AEO, especially on the second day (P = 0.023).
  
  
  CONCLUSIONS
  Despite the healing effects of AEO in burn wounds, petrolatum was more effective than AEO in post-laser wound.
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Jale
authors.initials: J
authors.lastname: Aliasl
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Khoshzaban
authors.affiliation: Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Barikbin
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Naseri
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Emadi
authors.affiliation: Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Razzaghi
authors.affiliation: Medicinal Plant Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Daryush
authors.initials: D
authors.lastname: Talei
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.affiliation: Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Aliasl
authors.affiliation: Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Barati
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Mohseni-Moghaddam
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Seyed Abbas
authors.initials: SA
authors.lastname: Hasheminejad
authors.affiliation: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Esmailzad Nami
keywords: Acne; Arnebia; Laser; Traditional Medicine; Wound Healing