title: Interstitial lung disease in anti-synthetase syndrome: initial and follow-up CT findings.
abstract: OBJECTIVE
  To describe the initial and follow-up CT features of interstitial lung disease associated with anti-synthetase syndrome (AS-ILD).
  
  
  METHODS
  Two independent thoracic radiologists retrospectively analysed thin-section CT images obtained at diagnosis of AS-ILD in 33 patients (17 positive for anti-Jo1, 13 for anti-PL12, and three for anti-PL7 antibodies). They evaluated the pattern, distribution and extent of the CT abnormalities. They also evaluated the change in findings during follow-up (median 27 months; range 13-167 months) in 26 patients.
  
  
  RESULTS
  At diagnosis, ground-glass opacities (100%), reticulations (87%) and traction bronchiectasis (76%) were the most common CT findings. Consolidations were present in 45% of patients. A non-specific interstitial pneumonia (NSIP), organizing pneumonia (OP) or mixed NSIP-OP CT pattern were observed in 15 out of 33 (45%), seven out of 33 (21%) and eight out of 33 (24%) patients, respectively, whereas the CT pattern was indeterminate in three patients. During follow-up, consolidations decreased or disappeared in 11 out of 12 patients (92%), among which seven within the first 6 months, but honeycombing progressed or appeared in ten out of 26 patients (38%) and overall disease extent increased in nine out of 26 patients (35%).
  
  
  CONCLUSIONS
  CT features at diagnosis of AS-ILD mainly suggest NSIP and OP, isolated or in combination. Consolidations decrease or disappear in most cases but the disease may progress to fibrosis in more than one third of patients.
authors.affiliation: AP-HP, Bichat-Claude Bernard Hospital, Department of Radiology, 46, rue Henri Huchard, 75877 Paris Cedex 18, France. Electronic address: marie-pierre.debray@bch.aphp.fr.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Debray
authors.affiliation: AP-HP, Bichat-Claude Bernard Hospital, Department of Pneumology A and Centre de Compétence Maladies Pulmonaires rares, DHU Fire 46, rue Henri Huchard, 75877 Paris Cedex 18, France; Inserm, U1152, Paris, France. Electronic address: raphael.borie@bch.aphp.fr.
authors.forename: Raphael
authors.initials: R
authors.lastname: Borie
authors.affiliation: AP-HP, Cochin Hospital, Department of Radiology, 27, Rue du Fg Saint Jacques, 75679 Paris Cedex 14, France. Electronic address: marie-pierre.revel@htd.aphp.fr.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Revel
authors.affiliation: AP-HP, Avicenne Hospital, Department of Pneumology and Centre de Compétence Maladies Pulmonaires rares, Bobigny, France; AP-HP, Tenon Hospital, Department of Pneumology and Centre de Compétence Maladies Pulmonaires rares, 4, rue de la Chine, 75020 Paris, France. Electronic address: jean-marc.naccache@tnn.aphp.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Naccache
authors.affiliation: AP-HP, Tenon Hospital, Department of Radiology, 4, rue de la Chine, 75020 Paris, France. Electronic address: antoine.khalil@tnn.aphp.fr.
authors.forename: Antoine
authors.initials: A
authors.lastname: Khalil
authors.affiliation: AP-HP, Tenon Hospital, Department of Pneumology and Centre de Compétence Maladies Pulmonaires rares, 4, rue de la Chine, 75020 Paris, France. Electronic address: cecile.toper@gmail.com.
authors.forename: Cécile
authors.initials: C
authors.lastname: Toper
authors.affiliation: Université Paris Descartes and AP-HP, Department of Pneumology, Georges Pompidou European Hospital, 20, rue Leblanc, 75015 Paris, France. Electronic address: dominique.israel-biet@egp.aphp.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Israel-Biet
authors.affiliation: AP-HP, Centre de Pharmaco-épidémiologie, Pôle Santé Publique, Recherche Clinique et Information Médicale, Hôpitaux Universitaires Paris-Nord Val de Seine, Site Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France; INSERM CIE 801, Paris, France. Electronic address: candice.estellat@bch.aphp.fr.
authors.forename: Candice
authors.initials: C
authors.lastname: Estellat
authors.affiliation: Université Paris XIII, PRES Sorbonne-Paris-Cité, UPRES EA 2363, Bobigny, France; AP-HP, Avicenne Hospital, Department of Radiology, 125, rue de Stalingrad, 93000 Bobigny, France. Electronic address: pybrillet@yahoo.fr.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Brillet
mesh_terms: D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: Aminoacyl-tRNA synthetase; Auto-immune disease; Computed tomography; Interstitial lung disease; Myositis