title: Neural systemic impairment from whole-body vibration.
abstract: Insidious brain microinjury from motor vehicle-induced whole-body vibration (WBV) has not yet been investigated. For a long time we have believed that WBV would cause cumulative brain microinjury and impair cerebral function, which suggests an important risk factor for motor vehicle accidents and secondary cerebral vascular diseases. Fifty-six Sprague-Dawley rats were divided into seven groups (n = 8): 1) 2-week normal control group, 2) 2-week sham control group (restrained in the tube without vibration), 3) 2-week vibration group (exposed to whole-body vibration at 30 Hz and 0.5g acceleration for 4 hr/day, 5 days/week, for 2 weeks), 4) 4-week sham control group, 5) 4-week vibration group, 6) 8-week sham control group, and 7) 8-week vibration group. At the end point, all rats were evaluated in behavior, physiological, and brain histopathological studies. The cerebral injury from WBV is a cumulative process starting with vasospasm squeezing of the endothelial cells, followed by constriction of the cerebral arteries. After the 4-week vibration, brain neuron apoptosis started. After the 8-week vibration, vacuoles increased further in the brain arteries. Brain capillary walls thickened, mean neuron size was obviously reduced, neuron necrosis became prominent, and wide-ranging chronic cerebral edema was seen. These pathological findings are strongly correlated with neural functional impairments.
authors.affiliation: Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Ji-Geng
authors.initials: JG
authors.lastname: Yan
authors.forename: Lin-ling
authors.initials: LL
authors.lastname: Zhang
authors.forename: Michael
authors.initials: M
authors.lastname: Agresti
authors.forename: John
authors.initials: J
authors.lastname: LoGiudice
authors.forename: James R
authors.initials: JR
authors.lastname: Sanger
authors.forename: Hani S
authors.initials: HS
authors.lastname: Matloub
authors.forename: Robert
authors.initials: R
authors.lastname: Havlik
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D004195:Disease Models, Animal; D019417:Hindlimb Suspension; D008297:Male; D018782:Maze Learning / Q000502:physiology; D046529:Microscopy, Electron, Transmission; D020768:Middle Cerebral Artery / Q000473:pathology / Q000648:ultrastructure; D053580:Muscle Strength / Q000502:physiology; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology*; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D014732:Vibration / Q000009:adverse effects*
chemical_list: D009569:Nitric Oxide; D010100:Oxygen
keywords: brain accumulated injury; brain dysfunction; brain edema; neuronal atrophy; neuronal necrosis; whole-body vibration