title: Prevalence and clinical distribution of multidrug-resistant bacteria (3537 isolates) in a tertiary Chinese hospital (January 2012-December 2013).
abstract: OBJECTIVE
  Multidrug-resistant organisms (MDROs) have become a widespread serious problem in recent years. Our objective was to determine the prevalence and clinical distribution of MDROs in a tertiary care hospital in China from January 1, 2012 to December 31, 2013.
  
  
  METHODS
  The strains were cultured according to standard methods; bacterial identification and susceptibility testing were detected by Vitek 2 system. The prevalence and clinical distribution of extended-spectrum β-lactamases (ESBLs)-producing enterobacteriaceae, carbapenem-resistant enterobacteriaceae (CRE), multiple-drug/pan-drug resistant P. aeruginosa (MDR/PDR-PA), carbapenem-resistant A. baumannii (CR-AB), methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were analyzed by WHONET 5.6.
  
  
  RESULTS
  A total of 3537 (33.4%) MDROs were found among 10,594 microbial isolates. ESBLs producing E. coli (ESBLs-ECO) (1153 cases) were the most frequent MDROs, followed by CR-AB (827 cases). The proportion of acquired resistance of A. baumannii (48.9%) accounted for the highest in all the MDROs. These MDROs were mainly isolated from respiratory (70.3%) and secretions (12.7%). Various types of intensive care unit (ICU) and surgery were the main source departments. The proportion of CRE and VRE were relatively few. CRE was most isolated from respiratory tract and closed body cavity fluid, while the distribution of VRE was relatively dispersed.
  
  
  CONCLUSIONS
  High prevalence of MDROs has emerged in our hospital, particular in various ICU and surgical department. The effective way to prevent the further spread of MDROs is to strengthen the protection of respiratory tract and surgical wounds.
authors.affiliation: Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Jia
authors.affiliation: Department of Clinical Laboratory, Liaocheng People's Hospital, 67, Dongchang Road, Liaocheng, Shandong 252000, China. Electronic address: pangfeng01@sina.cn.
authors.forename: F
authors.initials: F
authors.lastname: Pang
authors.affiliation: Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
authors.forename: J-Z
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
authors.forename: L-X
authors.initials: LX
authors.lastname: Jiang
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D001424:Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology*; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012189:Retrospective Studies; D013503:Surgery Department, Hospital / Q000706:statistics & numerical data; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D001618:beta-Lactamases
keywords: Distribution; Multidrug-resistant organisms; Organismes multi-résistants; Prevalence; Prévalence