title: Congenital neuroblastoma with placental involvement.
abstract: We describe an extremely rare case of congenital neuroblastoma with placental involvement. A fetus with a left abdominal mass detected during ultrasonography at 23 weeks' gestation developed hydrops fetalis by 26 weeks' gestation. The mother developed hypertension at 26 5/7 weeks' gestation. Based on a clinical diagnosis of pregnancy-induced hypertension, labor was induced at 26 6/7 weeks. However, intrauterine fetal death was diagnosed during delivery. Postmortern examination revealed a solid tumor at the site of the left adrenal gland. Histological examination of the tumor revealed dense proliferation of small round tumor cells with sparse cytoplasm and hyperchromatic nuclei. Some tumor-cell complexes contained abundant neurofibrils and Hormer-Wright rosettes were observed. A diagnosis of neuroblastoma of the left adrenal gland was made. The liver was markedly enlarged and was extensively replaced by neuroblastoma cells. In addition, small nests of tumor cells were detected in the blood vessels of various organs including the heart, lung, spleen, kidneys, stomach, small and large intestine, thyroid gland, testis, spinal cord, and bone marrow. Histological examination of the enlarged placenta revealed numerous neuroblastoma cells in the villous fetal capillary spaces. The present case was unusual in that the tumor cells were found not only in the chorionic villi, but also in the intervillous space of the maternal vascular system. However, there was no clinical evidence of maternal metastasis.
authors.affiliation: Department of Pathology, The University of Tokyo Hospital Tokyo, Japan ; School of Medicine, The University of Kyushu Fukuoka, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Kume
authors.affiliation: Department of Pathology, The University of Tokyo Hospital Tokyo, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Morikawa
authors.affiliation: Department of Pathology, The University of Tokyo Hospital Tokyo, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Ogawa
authors.affiliation: Department of Obstetrics and Gynecology, The University of Tokyo Hospital Tokyo, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Yamashita
authors.affiliation: Department of Obstetrics and Gynecology, The University of Tokyo Hospital Tokyo, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Department of Pathology, The University of Tokyo Hospital Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000151:congenital* / Q000473:pathology*; D000328:Adult; D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000151:congenital* / Q000556:secondary*; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy
keywords: Autopsy; fetal malignancy; immunohistochemistry; metastasis; tumor thrombus