title: Errors on interrupter tasks presented during spatial and verbal working memory performance are linearly linked to large-scale functional network connectivity in high temporal resolution resting state fMRI.
abstract: The brain is organized into networks composed of spatially separated anatomical regions exhibiting coherent functional activity over time. Two of these networks (the default mode network, DMN, and the task positive network, TPN) have been implicated in the performance of a number of cognitive tasks. To directly examine the stable relationship between network connectivity and behavioral performance, high temporal resolution functional magnetic resonance imaging (fMRI) data were collected during the resting state, and behavioral data were collected from 15 subjects on different days, exploring verbal working memory, spatial working memory, and fluid intelligence. Sustained attention performance was also evaluated in a task interleaved between resting state scans. Functional connectivity within and between the DMN and TPN was related to performance on these tasks. Decreased TPN resting state connectivity was found to significantly correlate with fewer errors on an interrupter task presented during a spatial working memory paradigm and decreased DMN/TPN anti-correlation was significantly correlated with fewer errors on an interrupter task presented during a verbal working memory paradigm. A trend for increased DMN resting state connectivity to correlate to measures of fluid intelligence was also observed. These results provide additional evidence of the relationship between resting state networks and behavioral performance, and show that such results can be observed with high temporal resolution fMRI. Because cognitive scores and functional connectivity were collected on nonconsecutive days, these results highlight the stability of functional connectivity/cognitive performance coupling.
authors.affiliation: Georgia Institute of Technology and Biomedical Engineering, Emory University, 1760 Haygood Dr, HSRB W230, Atlanta, GA, USA, 30322.
authors.forename: Matthew Evan
authors.initials: ME
authors.lastname: Magnuson
authors.affiliation: Georgia Institute of Technology and Biomedical Engineering, Emory University, 1760 Haygood Dr, HSRB W230, Atlanta, GA, USA, 30322.
authors.forename: Garth John
authors.initials: GJ
authors.lastname: Thompson
authors.affiliation: Georgia Institute of Technology School of Psychology, 654 Cherry Street, Atlanta, GA, USA, 30313.
authors.forename: Hillary
authors.initials: H
authors.lastname: Schwarb
authors.affiliation: Georgia Institute of Technology and Biomedical Engineering, Emory University, 1760 Haygood Dr, HSRB W230, Atlanta, GA, USA, 30322.
authors.forename: Wen-Ju
authors.initials: WJ
authors.lastname: Pan
authors.affiliation: Air Force Research Laboratory Wright-Patterson Air Force Base, Atlanta, OH, USA, 45433.
authors.forename: Andy
authors.initials: A
authors.lastname: McKinley
authors.affiliation: Georgia Institute of Technology School of Psychology, 654 Cherry Street, Atlanta, GA, USA, 30313.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Schumacher
authors.affiliation: Georgia Institute of Technology and Biomedical Engineering, Emory University, 1760 Haygood Dr, HSRB W230, Atlanta, GA, USA, 30322. shella.keilholz@bme.gatech.edu.
authors.forename: Shella Dawn
authors.initials: SD
authors.lastname: Keilholz
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D012146:Rest; D065852:Spatial Memory / Q000502:physiology; D013067:Speech Perception / Q000502:physiology; D055815:Young Adult
keywords: Cognitive processing; Default mode network; High temporal resolution fMRI; Interrupter task; Resting state; Task positive network; Working memory