title: Role of Chlamydia trachomatis and emerging Chlamydia-related bacteria in ectopic pregnancy in Vietnam.
abstract: In this case-control study, we investigated the seroprevalence and molecular evidence of Chlamydia trachomatis and Waddlia chondrophila in ectopic pregnancies (EP) and uneventful control pregnancies in 343 women from Vietnam. Whereas presence of C. trachomatis IgG was strongly associated with EP [adjusted odds ratio (aOR) 5·41, 95% confidence interval (CI) 2·58-11·32], its DNA remained undetected in all tubal lesions. We confirmed an independent association between antibodies against Waddlia and previous miscarriage (aOR 1·87, 95% CI 1·02-3·42). Further investigations are needed to understand the clinical significance of Waddlia's high seroprevalence (25·9% in control pregnancies) in this urban population.
authors.affiliation: Materno-fetal and Obstetrics Research Unit,Department of Obstetrics and Gynaecology,Maternity,University Hospital,Lausanne,Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Hornung
authors.affiliation: Tu Du Hospital,284 Cong Quynh Pham Ngu Lao Ward,District 1,Ho Chi Minh City,Vietnam.
authors.forename: B C
authors.initials: BC
authors.lastname: Thuong
authors.affiliation: Materno-fetal and Obstetrics Research Unit,Department of Obstetrics and Gynaecology,Maternity,University Hospital,Lausanne,Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Gyger
authors.affiliation: Center for Research on Intracellular Bacteria,Institute of Microbiology,Faculty of Biology and Medicine,University of Lausanne and University Hospital,Lausanne,Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Kebbi-Beghdadi
authors.affiliation: Materno-fetal and Obstetrics Research Unit,Department of Obstetrics and Gynaecology,Maternity,University Hospital,Lausanne,Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Vasilevsky
authors.affiliation: Center for Research on Intracellular Bacteria,Institute of Microbiology,Faculty of Biology and Medicine,University of Lausanne and University Hospital,Lausanne,Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Greub
authors.affiliation: Materno-fetal and Obstetrics Research Unit,Department of Obstetrics and Gynaecology,Maternity,University Hospital,Lausanne,Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Baud
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000302:isolation & purification; D002695:Chlamydiales / Q000276:immunology / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000032:analysis; D005187:Fallopian Tubes / Q000737:chemistry / Q000382:microbiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D010920:Placenta / Q000737:chemistry / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000382:microbiology; D011271:Pregnancy, Ectopic / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D007074:Immunoglobulin G
keywords: Adverse pregnancy outcome; Chlamydia-related bacteria; ectopic pregnancy; genital tract infection; intracellular bacteria