title: Stereotactic ablative radiation therapy as first local therapy for lung oligometastases from colorectal cancer: a single-institution cohort study.
abstract: OBJECTIVE
  To estimate stereotactic ablative radiation therapy (SABR) efficacy and its potential role as an alternative to surgery for the treatment of lung metastases from colorectal cancer.
  
  
  METHODS
  Forty consecutive patients who received SABR as first local therapy at the time of lung progression were included, from 2004 to 2014. The primary study endpoint was overall survival. Secondary endpoints were progression-free survival and safety.
  
  
  RESULTS
  A single nodule was treated in 26 patients (65%), 2 nodules in 10 patients (25%), 3 in 3 patients (7.5%), and 4 in 1 patient (2.5%), for a total of 59 lesions. The median delivered biological effective dose was 96 Gy, in 1 to 8 daily fractions. Median follow-up time was 20 months (range, 3-72 months). Overall survival rates at 1, 2, and 5 years were, respectively, 84%, 73%, and 39%, with 14 patients (35%) dead. Median overall survival was 46 months. Progression occurred in 25 patients (62.5%), at a median interval of 8 months; failure at SABR site was observed in 3 patients (7.5%). Progression-free survival rates were 49% and 27% at 1 and 2 years, respectively.
  
  
  CONCLUSIONS
  The results of this retrospective exploratory analysis suggest safety and efficacy of SABR in patients affected with colorectal cancer lung oligometastases and urge inclusion of SABR in prospective clinical trials.
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Torino, Italy. Electronic address: andreariccardo.filippi@unito.it.
authors.forename: Andrea Riccardo
authors.initials: AR
authors.lastname: Filippi
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Torino, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Badellino
authors.affiliation: Cancer Epidemiology and CPO Piemonte, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Ceccarelli
authors.affiliation: Radiation Oncology, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Guarneri
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Torino, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.affiliation: Cancer Epidemiology and CPO Piemonte, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Monagheddu
authors.affiliation: Medical Oncology, Colorectal Cancer Unit, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Rosella
authors.initials: R
authors.lastname: Spadi
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Torino, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ragona
authors.affiliation: Medical Oncology, Colorectal Cancer Unit, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Racca
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Torino, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Ricardi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D015996:Survival Rate