title: [Transient hemorrhagic diathesis caused by prothrombin-binding antiphospholipid antibody in a child].
abstract: We describe three previously healthy children who developed acute extensive bruises about two weeks after a mild stomach bug. Coagulation tests revealed a shortened thromboplastin time (TT), long PT time, low level of coagulation factor II, and positive lupus anticoagulant among the antiphospholipid antibodies. In one patient the clinical symptoms disappeared during a one-week course of prednisolone, another one received a prothrombin complex preparation as substitution therapy. In the third patient the symptoms were milder and vanished without any specific treatment. The levels of coagulation factor increased in all patients and the lupus anticoagulant disappeared within a couple of months.
authors.affiliation: OYS, Lasten ja nuorten klinikka.
authors.forename: Merja
authors.initials: M
authors.lastname: Möttönen
authors.forename: Leena
authors.initials: L
authors.lastname: Hiltunen
authors.forename: Jukka
authors.initials: J
authors.lastname: Rajantie
authors.forename: Hanna
authors.initials: H
authors.lastname: Juntti
authors.forename: Anne
authors.initials: A
authors.lastname: Mäkipernaa
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood*; D001780:Blood Coagulation Tests; D002648:Child; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006474:Hemorrhagic Disorders / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D011516:Prothrombin / Q000627:therapeutic use
chemical_list: D017152:Antibodies, Antiphospholipid; D005938:Glucocorticoids; D011516:Prothrombin; D011239:Prednisolone