title: [Demonstration of nested case-control study design in mechanisms research of allergic reaction of tanreqing injection].
abstract: The paper is focused on the clinical applications of Tanreqing injection after listing, detecting and analyzing the related blood indicators of patients with allergic reactions based on prospective, multi-center, large sample, registration-type clinical safety monitoring nested case-control study (NCCS) to explore the possible mechanisms of allergic reaction of Tanreqing injection, 3 006 patients cases used with Tanreqing injection were monitored, including 3 cases of adverse reactions and 2 cases of allergic reactions. Each patient of allergic reactions, according to the ratio of 1:4 matches four cases of not adverse reactions as a control group of patients, while 5 healthy and 5 cases of volunteers into the healthy group. We examined the correlation detection of cases of allergic reactions among groups such as T-IgE, IgA, IgG, C3, C4, IFN-g, IL-2, IL-4, IL-6, IL-10. Allergic reactions of Tanreqing injection may be mediated by IgE as type I based on existing research data. This results and conclusions will promote the justifiability and safety of clinical applications.
authors.forename: Peng-Yang
authors.initials: PY
authors.lastname: Xie
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Xie
authors.forename: Lian-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Yan-Peng
authors.initials: YP
authors.lastname: Chang
authors.forename: Shao-Yong
authors.initials: SY
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015850:Interleukin-6; C540817:tanreqing; D016753:Interleukin-10; D015847:Interleukin-4