title: Systematic review of health-related quality of life issues in locally recurrent rectal cancer.
abstract: The standardization of surgical techniques supplemented with appropriate neoadjuvant chemoradiation has led to the decline in local recurrence rates of rectal cancer (LRRC) from 25-50% to 5-10%. The outcomes reported for surgical intervention in LRRC is encouraging, however, a number of controversies exist especially in the ultra-advanced and palliative setting. Incorporating health-related quality of life (HRQoL) outcomes in this field could supplement traditional clinical endpoints in assessing the effectiveness of surgical intervention in this cohort. This review aimed to identify the HRQOL themes that might be relevant to patients with LRRC. A systematic review was undertaken to identify all studies reporting HRQoL in LRRC. Each study was evaluated with regards to its design and statistical methodology. A meta-synthesis of qualitative and quantitative studies was undertaken to identify relevant HRQoL themes. A total of 14 studies were identified, with 501 patients, with 80% of patients undergoing surgery. HRQoL was the primary endpoint in eight studies. Eight themes were identified: physical, psychological and social impact, symptoms, financial and occupational impact, relationships with others, communication with healthcare professionals and sexual function. The impact on HRQoL is multifactorial and wide ranging, with a number of issues identified that are not included in current measures. These issues must be incorporated into the assessment of HRQoL in LRRC through the development of a validated, disease-specific tool.
authors.affiliation: The John Goligher Department of Colorectal Surgery, St James's University Hospital, Leeds, UK; St James's Institute of Oncology, St James's University Hospital, Leeds, UK.
authors.forename: Deena P
authors.initials: DP
authors.lastname: Harji
authors.forename: Ben
authors.initials: B
authors.lastname: Griffiths
authors.forename: Galina
authors.initials: G
authors.lastname: Velikova
authors.forename: Peter M
authors.initials: PM
authors.lastname: Sagar
authors.forename: Julia
authors.initials: J
authors.lastname: Brown
mesh_terms: D003142:Communication; D006801:Humans; D007398:Interpersonal Relations; D018908:Muscle Weakness / Q000503:physiopathology; D009364:Neoplasm Recurrence, Local / Q000503:physiopathology* / Q000523:psychology*; D010146:Pain / Q000503:physiopathology; D011369:Professional-Patient Relations; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000503:physiopathology* / Q000523:psychology*; D062707:Return to Work; D020018:Sexual Dysfunctions, Psychological; D012919:Social Behavior
keywords: health-related quality of life; locally recurrent rectal cancer; patient-reported outcomes