title: Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis.
abstract: BACKGROUND
  The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.
  
  
  METHODS
  PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.
  
  
  METHODS
  Clinical review.
  
  
  METHODS
  Level 3.
  
  
  RESULTS
  We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
  
  
  CONCLUSIONS
  While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.
authors.affiliation: University Health Network Arthritis Program, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Jesse I
authors.initials: JI
authors.lastname: Wolfstadt
authors.affiliation: Rush University Medical Centre, Chicago, Illinois.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Cole
authors.affiliation: University Health Network Arthritis Program, University of Toronto, Toronto, Ontario, Canada ; University of Toronto Orthopaedic Sports Medicine Program, Women's College Hospital, Toronto, Ontario, Canada.
authors.forename: Darrell J
authors.initials: DJ
authors.lastname: Ogilvie-Harris
authors.affiliation: Cell Therapy Program, University Health Network, Toronto, Ontario, Canada.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Viswanathan
authors.affiliation: University Health Network Arthritis Program, University of Toronto, Toronto, Ontario, Canada ; University of Toronto Orthopaedic Sports Medicine Program, Women's College Hospital, Toronto, Ontario, Canada.
authors.forename: Jaskarndip
authors.initials: J
authors.lastname: Chahal
keywords: mesenchymal stem cells; osteoarthritis; treatment