title: [Mixed (photon-neutron) therapy in complex treatment for locally advanced breast cancer].
abstract: Long term results of treatment of patients with locally advanced breast carcinoma with the use of mixed photon-neutron therapy (PNT) are presented. Among 201 patients with locally advanced breast cancer receiving radiation therapy, in 95 of them it was implemented as a combination of photon and neutron radiation therapy and in 106--in the form of mega-volt photon therapy (PT). Comparative evaluation of the long-term results of treatment proved the superiority of PNT. The immediate effect after PNT in the form of complete and partial response of tumor was registered in 87.4%, and after PT--in 49% of cases. Five-year and ten-year survival rates without signs of disease after PNT were 58.1% and 29.5%, and after PT--36.4% and 7.4% respectively. Substantial differences in toxicity of techniques were not observed.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Mardynskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Gulidov
authors.forename: G G
authors.initials: GG
authors.lastname: Aminov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Ragulin
authors.forename: A S
authors.initials: AS
authors.lastname: Sysoev
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy*; D005214:Fast Neutrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017785:Photons / Q000627:therapeutic use*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome