title: Finger necrosis due to cryoglobulinemic vasculitis in association with membranous nephropathy.
abstract: Cryoglobulinemic vasculitis is a small vessel vasculitis that has been associated with chronic infections and autoimmune, lymphoproliferative, and neoplastic disorders. When no significant etiological factors are identified, it is called essential mixed cryoglobulinemia. A detailed and thorough laboratory investigation is required to exclude all possible causes of cryoglobulin formation. Although cryoglobulin testing is simple, careful temperature regulation is needed to avoid false-negative results. Consensus diagnosis should be developed and implemented for appropriate cryoglobulin detection and accurate clinical diagnosis for cryoglobulinemic vasculitis. Here we present an interesting, first-ever case report of a 54-year-old Hispanic-American woman with essential mixed cryoglobulinemia presenting with significant digital necrosis in association with membranous nephropathy.
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Mateo
authors.initials: M
authors.lastname: Porres-Aguilar
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rodriguez-Castro
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Padilla
authors.initials: P
authors.lastname: Osvaldo
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Fátima
authors.initials: F
authors.lastname: Saifuddin
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Tariq
authors.initials: T
authors.lastname: Siddiqui
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Jerry
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Debabrata
authors.initials: D
authors.lastname: Mukherjee
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Kanchan
authors.initials: K
authors.lastname: Pema
authors.affiliation: Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
authors.forename: Aamer
authors.initials: A
authors.lastname: Abbas