title: Serum autotaxin levels correlate with hepatic dysfunction and severity in postoperative biliary atresia.
abstract: OBJECTIVE
  To investigate correlation of serum autotaxin and disease severity in biliary atresia (BA).
  
  
  METHODS
  Eighty postoperative BA patients and 15 controls were recruited. Serum autotaxin levels were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  BA patients had greater serum autotaxin and liver stiffness than controls. Serum autotaxin and liver stiffness were markedly elevated in BA patients with jaundice compared to those without jaundice. Furthermore, serum autotaxin was correlated with liver stiffness and biochemical parameters in BA.
  
  
  CONCLUSIONS
  Elevated serum autotaxin was correlated with hepatic dysfunction in BA. Accordingly, serum autotaxin is a promising biomarker reflecting the severity in BA.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand .
authors.forename: Wanvisa
authors.initials: W
authors.lastname: Udomsinprasert
authors.forename: Sittisak
authors.initials: S
authors.lastname: Honsawek
authors.forename: Wilai
authors.initials: W
authors.lastname: Anomasiri
authors.forename: Voranush
authors.initials: V
authors.lastname: Chongsrisawat
authors.forename: Paisarn
authors.initials: P
authors.lastname: Vejchapipat
authors.forename: Yong
authors.initials: Y
authors.lastname: Poovorawan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001656:Biliary Atresia / Q000097:blood* / Q000473:pathology / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000097:blood*; D011184:Postoperative Period; D000099189:Lysophospholipase D
chemical_list: D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001219:Aspartate Aminotransferases; D001663:Bilirubin; D015415:Biomarkers; D010727:Phosphoric Diester Hydrolases; D000099189:Lysophospholipase D
keywords: Autotaxin; biliary atresia; jaundice; liver stiffness; severity