title: Human mesenchymal stromal cell lysates as a novel strategy to recover liver function.
abstract: OBJECTIVE
  It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties.
  
  
  METHODS
  The effects of intact MSC transplantation were compared with the infusion of MSC lysates in an experimental rat model of acute liver failure.
  
  
  RESULTS
  A more powerful hepatoprotective and antiapoptotic effect was obtained after infusion of MSC lysates than intact MSC. Changes in IL-6 levels and miRNAs might explain the beneficial effects of MSC lysates.
  
  
  CONCLUSIONS
  Infusion of MSC lysates show a better hepatoprotective effect than the transplantation of intact MSC.
authors.affiliation: Maimónides Institute for Biomedical Research (IMIBIC)/Reina Sofia University Hospital/University of Córdoba, Avda Menendez-Pidal s/n, CP. 14004, Córdoba, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Herencia
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Almadén
authors.forename: Julio M
authors.initials: JM
authors.lastname: Martínez-Moreno
authors.forename: Isabel
authors.initials: I
authors.lastname: Espejo
authors.forename: Concha
authors.initials: C
authors.lastname: Herrera
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez-Sánchez
authors.forename: Fátima
authors.initials: F
authors.lastname: Guerrero
authors.forename: Rubén
authors.initials: R
authors.lastname: Ciria
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Briceño
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ferrín
authors.forename: Manuel
authors.initials: M
authors.lastname: de la Mata
authors.forename: Juan R
authors.initials: JR
authors.lastname: Muñoz-Castañeda
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002457:Cell Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008107:Liver Diseases / Q000473:pathology / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D035683:MicroRNAs / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology; D011169:Portal Vein / Q000502:physiology; D017208:Rats, Wistar; D013853:Thioacetamide / Q000008:administration & dosage; D018800:Thy-1 Antigens / Q000378:metabolism
chemical_list: D002457:Cell Extracts; D016207:Cytokines; D035683:MicroRNAs; D018800:Thy-1 Antigens; D013853:Thioacetamide
keywords: acute liver failure; apoptosis; cell lysates; cell therapy; mesenchymal stromal cells