title: Epstein-Barr virus-positive plasmacytoma in immunocompetent patients.
abstract: OBJECTIVE
  Extramedullary plasmacytomas are often localized, clinically indolent neoplasms, and affected patients usually respond to radiation therapy or limited cycles of chemotherapy. In contrast, plasmablastic lymphomas are clinically aggressive neoplasms composed of immunoblastic or plasmablastic cells and associated with more mature plasma cells in some cases. Patients with plasmablastic lymphoma usually have a poor prognosis despite aggressive chemotherapy. Evidence of Epstein-Barr virus (EBV) infection is uncommon in plasmacytoma, but common in plasmablastic lymphoma, and is therefore helpful in differential diagnosis. The aim of this study is to describe four cases of plasmacytoma arising in immunocompetent individuals that were diffusely positive for Epstein-Barr virus-encoded small RNA as shown by in-situ hybridization.
  
  
  RESULTS
  We describe the clinicopathological and immunophenotypic findings of four EBV-positive plasmacytomas arising in immunocompetent patients. These tumours were characterized by diffuse proliferation of mature-appearing plasma cells intermixed with a briskly reactive, CD8-positive, TIA-1-positive cytotoxic T-cell infiltrate. Long-term follow-up was available for all patients, and all were alive and free of disease at last follow-up (median 43.4 months).
  
  
  CONCLUSIONS
  We suggest the term EBV-positive plasmacytoma in immunocompetent patients for these lesions. It is essential to distinguish these tumours from plasmablastic lymphoma, as the latter diagnosis is associated with a much poorer prognosis, and patients require much more aggressive therapy.
authors.affiliation: Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
authors.forename: Sanam
authors.identifier: http://orcid.org/0000-0001-8980-3202
authors.initials: S
authors.lastname: Loghavi
authors.affiliation: Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Khoury
authors.affiliation: Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
mesh_terms: D000328:Adult; D000368:Aged; D016827:CD8 Antigens / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000628:therapy / Q000821:virology*; D004938:Esophageal Neoplasms / Q000276:immunology / Q000628:therapy / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D017403:In Situ Hybridization; D008297:Male; D008479:Mediastinal Neoplasms / Q000276:immunology / Q000628:therapy / Q000821:virology*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000276:immunology / Q000628:therapy / Q000821:virology*; D010954:Plasmacytoma / Q000276:immunology / Q000628:therapy / Q000821:virology*; D039102:Poly(A)-Binding Proteins / Q000378:metabolism; D011379:Prognosis; D012367:RNA, Viral / Q000235:genetics; D000074019:T-Cell Intracellular Antigen-1
chemical_list: D016827:CD8 Antigens; D039102:Poly(A)-Binding Proteins; D012367:RNA, Viral; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human
keywords: CD8-positive T cells; Epstein-Barr virus; plasmablastic lymphoma; plasmacytoma