title: Participation of NMDA receptors in the lateral hypothalamus in gastric erosion induced by cold-water restraint.
abstract: The present study investigated whether neurons in the lateral hypothalamus (LH) play a role in the occurrence of gastric ulcerations induced by cold-water restraint. The first experiment indicated that bilateral N-methyl-d-aspartate (NMDA) lesions of the LH (20μg/1μl per side) reduced the amount of gastric ulceration induced by cold-water restraint. In the second experiment, the NMDA antagonist DL-2-amino-5-phosphonovaleric acid (APV; 2.5μg/0.5μl per side) or its vehicle was microinjected bilaterally into the LH prior to the cold-water restraint procedure. APV did not induce gastric ulcerations but reduced the amount of ulceration induced by cold-water restraint. These results indicate that NMDA receptors in the LH play an important role in the occurrence of gastric ulceration induced by cold-water restraint. The participation of the LH and possible neuronal circuitry involved in stress-induced ulceration are discussed.
authors.affiliation: Departamento de Psicologia, Pontifícia Universidade Católica, Rio de Janeiro, Brazil. Electronic address: landeira@puc-rio.br.
authors.forename: J
authors.initials: J
authors.lastname: Landeira-Fernandez
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012149:Restraint, Physical / Q000009:adverse effects*; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine
keywords: Cold-water restraint; Gastric ulceration; Lateral hypothalamus; NMDA receptors