title: Renal function and ultrasound imaging in elderly subjects.
abstract: We evaluated in elderly subjects (a) the ability of GFR formulas to discriminate chronic kidney disease (CKD), (b) the correlation between renal morphology and function, and (c) the usefulness of combined r-US and GFR formulas to detect CKD. A total of 72 patients were enrolled (mean age 80±7 years, male sex 44%, serum creatinine 0.98±0.42 mg/dL, and CKD 57%). Cockcroft-Gault showed the highest sensitivity (78%) and specificity (94%) for CKD and was correlated with kidney volume (R=0.68, P<0.001). All formulas failed to provide a reliable estimate of GFR. In multivariate analysis, Cockcroft-Gault<52 mL/min and kidney sinus section area<28 cm2 showed the highest accuracy for the identification of CKD subjects (AUC 0.90, P<0.001). MDRD and CKD-EPI differed significantly for GFR≥90 mL/min.
  
  
  CONCLUSIONS
  Cockcroft-Gault<52 mL/min was able to discriminate subjects with CKD but all formulas failed to provide a reliable estimate of GFR. The combined use of r-US and Cockcroft-Gault formula improved the ability to discriminate CKD in elderly subjects.
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Luca
authors.identifier: 0000-0003-1678-3778
authors.initials: L
authors.lastname: Zanoli
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Romano
authors.affiliation: Department of Geriatrics, Garibaldi Hospital, 95100 Catania, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Romano
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Stefania
authors.identifier: 0000-0002-5253-785X
authors.initials: S
authors.lastname: Rastelli
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Rapisarda
authors.affiliation: Nephrology and Dialysis Unit, "San Giovanni di Dio" Hospital, 92100 Agrigento, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Granata
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fatuzzo
authors.affiliation: Department of Scienze della Senescenza, University of Catania, 95100 Catania, Italy.
authors.forename: Mariano
authors.identifier: 0000-0003-0502-491X
authors.initials: M
authors.lastname: Malaguarnera
authors.affiliation: Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Castellino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003710:Demography; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D012372:ROC Curve; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging / Q000503:physiopathology; D018709:Statistics, Nonparametric; D014465:Ultrasonics / Q000379:methods*; D014463:Ultrasonography