title: Renal perfusional cortex volume for arterial input function measured by semiautomatic segmentation technique using MDCT angiographic data with 0.5-mm collimation.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the usefulness of renal perfusional cortex volume for arterial input function.
  
  
  METHODS
  This retrospective study included 45 potential kidney donors--33 patients with aortic dissection and 12 patients with renovascular hypertension--who underwent both MDCT angiography with 0.5-mm collimation and renal (99m)Tc-diethylenetriamine pentaacetic acid (DTPA) scanning using the modified Gates method. Each perfusional cortex volume for the arterial input function and parenchymal volume was measured by semiautomatic segmentation using the region-growing technique. Linear regression analysis and correlation coefficients were used to assess the impact of the cortical volume, parenchymal volume, and renal scanning glomerular filtration rate (GFR) on estimated GFR (eGFR) using a modified Modification of Diet in Renal Disease (MDRD) equation.
  
  
  RESULTS
  The correlation coefficient was higher for the total renal DTPA GFR adjusted for body surface area, weight-adjusted perfusion cortex volume, and adjusted total parenchyma volume in rank (r = 0.712, 0.642, 0.510, respectively, p< 0.0001 for each). The coefficient of the right renal perfusional cortex volume percent with a mean value of 52.1% ± 10.1% was 0.826 (p < 0.0001) for the right renal DTPA GFR percent with a mean value of 51.0% ± 12.1% (range, 22.0-89.5%), although the value for the right renal parenchymal volume percent with a mean value of 49.5% ± 5.5% was 0.764 (p < 0.0001).
  
  
  CONCLUSIONS
  Weight-adjusted perfusional cortex volume for arterial input function can be measured clinically and may replace renal DTPA scanning using the modified Gates method.
authors.affiliation: 1 Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Torimoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Takebayashi
authors.forename: Zenjiro
authors.initials: Z
authors.lastname: Sekikawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Teranishi
authors.forename: Keiji
authors.initials: K
authors.lastname: Uchida
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000792:Angiography / Q000379:methods*; D001810:Blood Volume; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D012077:Renal Artery; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid
keywords: MDCT; glomerular filtration rate; renal scintigraphy; renal volume; segmentation algorithm