title: Late Manifestation of Struma Peritonei and Widespread Functioning Lesions in the Setting of Struma Ovarii Simulating Highly Differentiated Follicular Carcinoma.
abstract: Malignant transformation of struma ovarii is a rare event observed in about 5% of cases. We present here an unusual case that closely simulated highly differentiated follicular carcinoma, an entity with a relatively similar appearance to malignant struma ovarii. In our case, peritoneal and systemic dissemination occurred 18 y after excision of struma ovarii, which had been reported as histopathologically benign. There were 3 noteworthy features in the case: the highly functioning nature of the lesions (evidenced by a low level of thyroid-stimulating hormone even without thyroxine suppression); the low to minimal (18)F-FDG avidity of the foci, which reiterates the well-differentiated nature of these lesions, as expected in highly differentiated follicular carcinoma; and prominent involvement of rare sites such as spleen and liver, in addition to usual sites such as lungs, peritoneum, and bilateral adnexae.
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Mumbai, India; and.
authors.forename: Rohit
authors.initials: R
authors.lastname: Ranade
authors.affiliation: Department of Nuclear Medicine, Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Rachh
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Mumbai, India; and drsanb@yahoo.com.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013330:Struma Ovarii / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG PET/CT; peritoneal strumosis; radioiodine scan; struma ovarii