title: Review: phage therapy: a modern tool to control bacterial infections.
abstract: The evolution of antibiotic-resistant in bacteria has aggravated curiosity in development of alternative therapy to conventional drugs. One of the emerging drugs that can be used alternative to antibiotics is bacteriophage therapy. The use of living phages in the cure of lethal infectious life threatening diseases caused by Gram positive and Gram negative bacteria has been reported. Another development in the field of bacteriophage therapy is the use of genetically modified and non replicating phages in the treatment of bacterial infection. Genetically engineered bacteriophages can be used as adjuvant along with antibiotic therapy. Phages encoded with lysosomal enzymes are also effectual in the treatment of infectious diseases.
authors.affiliation: Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity / Q000821:virology*; D001424:Bacterial Infections / Q000175:diagnosis / Q000266:history / Q000382:microbiology / Q000628:therapy*; D001435:Bacteriophages / Q000235:genetics* / Q000472:pathogenicity; D024881:Drug Resistance, Bacterial; D015316:Genetic Therapy / Q000266:history / Q000379:methods*; D005838:Genotype; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans