title: The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review.
abstract: Among all heterocycles, the heterocycle-fused quinolinone scaffold is one of the privileged structures in drug discovery as heterocycle-fused quinolinone derivatives exhibit various biological activities allowing them to act as anti-inflammatory, anticancer, antidiabetic, and antipsychotic agents. This wide spectrum of biological activity has attracted a great deal of attention in the field of medicinal chemistry. In this review, we provide a comprehensive description of the biological and pharmacological properties of various heterocycle-fused quinolinone scaffolds and discuss the synthetic methods of some of their derivatives.
authors.affiliation: Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd., Enoki 33-94, Suita, Osaka 564-0053, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Shiro
authors.affiliation: Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd., Enoki 33-94, Suita, Osaka 564-0053, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fukaya
authors.affiliation: Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd., Enoki 33-94, Suita, Osaka 564-0053, Japan. Electronic address: masanori-tobe@ds-pharma.co.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Tobe
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D006571:Heterocyclic Compounds; D015363:Quinolones
keywords: Heterocycles; Quinolin-4-one; Quinolinone