title: Serum endocan concentration in women with pre-eclampsia.
abstract: OBJECTIVE
  To investigate serum endocan levels in pregnant subjects with and without pre-eclampsia.
  
  
  METHODS
  This cross-sectional study was conducted on 49 pregnant women with pre-eclampsia and 32 healthy pregnant women matched for gestational age. Maternal levels of serum endocan were measured with the use of an enzyme-linked immunosorbent assay kit.
  
  
  RESULTS
  Mean endocan levels were not significantly different among groups (10.7 ± 4.5 vs. 10.3 ± 3.2 ng/mL, p 0.763). Mean uterine artery PI and RI were higher in the pre-eclampsia group (p < 0.001, p < 0.001). Mean endocan levels were negatively correlated with BMI at the time of blood sampling (r = -0.247, p = 0.044). There was no correlations between mean endocan levels and all the others parameters.
  
  
  CONCLUSIONS
  These findings suggest that the role of endocan in the pathogenesis of pre-eclampsia was not related to pre-eclampsia; hence, further studies are needed to investigate the role of endocan in the pathogenesis of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Kocamustafapasa, Istanbul, Turkey, maytacyuksel@gmail.com.
authors.forename: Mehmet Aytac
authors.initials: MA
authors.lastname: Yuksel
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuten
authors.forename: Mahmut
authors.initials: M
authors.lastname: Oncul
authors.forename: Abdullah Serdar
authors.initials: AS
authors.lastname: Acikgoz
authors.forename: Ilkbal
authors.initials: I
authors.lastname: Temel Yuksel
authors.forename: Muhammet Sait
authors.initials: MS
authors.lastname: Toprak
authors.forename: Hakan
authors.initials: H
authors.lastname: Ekmekci
authors.forename: Ozlem
authors.initials: O
authors.lastname: Balci Ekmekci
authors.forename: Riza
authors.initials: R
authors.lastname: Madazli
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011509:Proteoglycans / Q000097:blood*; D055988:Uterine Artery / Q000378:metabolism*; D055815:Young Adult
chemical_list: C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans