title: Leukoderma in patients with atopic dermatitis.
abstract: Atopic dermatitis (AD) is occasionally associated with vitiligo, however, the incidence and conditions of vitiligo or leukoderma, and the characteristics of concurrent AD, remain unclear. We conducted a prospective observational study to investigate the leukoderma-related clinical manifestations and bioparameters of AD. Because vitiligo in AD lesions is occasionally associated with inflammation, we used leukoderma in this study. Enrolled were all AD patients who had been followed up in our AD outpatient clinic and visited within the previous 4 months. During this period, we carefully inspected whether the patients had leukoderma. Eight of 52 patients had leukoderma (15.4%) and were designated as the leukoderma group, and the remaining 44 patients comprised the non-leukoderma group. While the ages were statistically not different between the two groups, female preponderance was significantly observed in the leukoderma group. The leukoderma patients tended to have higher values of SCORAD, CCL17/thymus and activation regulated chemokine and lactate dehydrogenase than the non-leukoderma patients. The leukoderma group was also characterized by a lower frequency of allergic rhinitis and a higher frequency of prurigo lesions. Thus, despite the possession of high AD severity, the leukoderma patients may possibly retain a relatively T-helper 1-skewing state in relation to the development of leukoderma and less association with rhinitis.
authors.affiliation: Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Akira
authors.initials: A
authors.lastname: Kasuya
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Fujiyama
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tatsuno
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Sakabe
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Taisuke
authors.initials: T
authors.lastname: Ito
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000293:Adolescent; D000328:Adult; D054414:Chemokine CCL17 / Q000097:blood; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood / Q000150:complications*; D005260:Female; D000091344:Filaggrin Proteins; D006801:Humans; D017496:Hypopigmentation / Q000097:blood / Q000150:complications*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011536:Prurigo / Q000150:complications; D065631:Rhinitis, Allergic / Q000150:complications; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
chemical_list: D054414:Chemokine CCL17; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007770:L-Lactate Dehydrogenase
keywords: atopic dermatitis; filaggrin; leukoderma; thymus and activation regulated chemokine; vitiligo