title: The correlation of ECHO findings of right cardiac pathologies with BNP, uric acid, and CRP in OSAS.
abstract: OBJECTIVE
  Right cardiac pathologies develop in patients with obstructive sleep apnea syndrome (OSAS) and in most patients there are no symptoms in the early stages of right cardiac disorders. We aimed to evaluate a possible relationship between B-type natriuretic peptide (BNP), blood uric acid, C-reactive protein (CRP), and the right cardiac pathologies in patients with OSAS, and the role of these parameters in the management of patients with OSAS.
  
  
  METHODS
  A total of 98 subjects, 31 (31.6%) controls and 67 (68.4%) with OSAS, were included in the study. All the subjects underwent polysomnography, and standard and tissue Doppler echocardiography (ECHO) examinations. BNP, CRP, and blood uric acid levels were measured in all patients.
  
  
  RESULTS
  Upon evaluating the relationship between BNP and ECHO parameters, BNP levels were found to positively correlate with such ECHO parameters as pulmonary artery pressure. As for the association between CRP and ECHO findings, RV diameter exhibited a statistically significant positive correlation with them. Moreover, uric acid was found to statistically correlate positively with right atrium dimensions.
  
  
  CONCLUSIONS
  BNP, CRP, and blood uric acid levels can be used as adjunctive parameters in the early diagnosis and follow-up of right heart pathologies in patients with OSAS.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Araz
authors.forename: Elif
authors.initials: E
authors.lastname: Yilmazel Uçar
authors.forename: Hüsnü
authors.initials: H
authors.lastname: Değırmencı
authors.forename: Didem
authors.initials: D
authors.lastname: Pulur
authors.forename: Hamit
authors.initials: H
authors.lastname: Acemoğlu
authors.forename: Ednan
authors.initials: E
authors.lastname: Bayram
authors.forename: Fuat
authors.initials: F
authors.lastname: Gündoğdu
authors.forename: Metin
authors.initials: M
authors.lastname: Akgün
mesh_terms: D000328:Adult; D015897:Comorbidity; D015150:Echocardiography, Doppler; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D020097:Natriuretic Peptide, Brain; D014527:Uric Acid