title: Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland.
abstract: OBJECTIVE
  To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics.
  
  
  METHODS
  A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test.
  
  
  RESULTS
  P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, P63, and P73 proteins was not associated with age, sex, or lymph node metastasis (P > 0.05). Expression of P53 and P73 proteins, instead of the P63 protein, was correlated to the degree of malignancy (P = 0.026 and 0.018, respectively). There was no significant difference among the P53, P73, and P63 proteins in malignant parotid gland tumors (P > 0.05). In the follow-up, only one patient died of colon cancer.
  
  
  CONCLUSIONS
  Our results suggest that the P53, P63, and P73 proteins may play a role in the development of malignant parotid gland tumors and provide data for their diagnosis.
authors.forename: Mei
authors.initials: M
authors.lastname: Yong
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Qimuge
authors.initials: Q
authors.lastname: Suyila
authors.forename: Wenyan
authors.initials: W
authors.lastname: Han
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yuan
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhao
authors.forename: Xiulan
authors.initials: X
authors.lastname: Su
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018298:Mucoepidermoid Tumor / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D010307:Parotid Neoplasms / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C115051:TP63 protein, human; C000606460:TP73 protein, human; D014157:Transcription Factors; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins