title: Panton-Valentine leukocidin positive Staphylococcal aureus infections of the head and neck: case series and brief review of literature.
abstract: Panton-valentine leukocidin (PVL) is a pore-forming cytotoxin produced by some clones of Staphylococcus aureus that is associated with infections ranging from uncomplicated skin and soft tissue infections to life-threatening necrotizing pneumonia. PVL S aureus-associated maxillofacial infections are rarely reported; therefore, a high degree of clinical suspicion is warranted and close liaison with microbiologists and appropriate samples are required for optimal management. This report discusses the management and learning points from 3 such cases managed by the Greater Glasgow and Clyde National Health Service maxillofacial surgical teams.
authors.affiliation: Senior Clinical Fellow of Head and Neck Oncology, Department of Oral and Maxillofacial Surgery Department, Southern General Hospital, Glasgow, United Kingdom. Electronic address: johnhanratty@hotmail.com.
authors.forename: John
authors.initials: J
authors.lastname: Hanratty
authors.affiliation: Specialist Registrar, Department of Microbiology, Southern General Hospital, Glasgow, United Kingdom.
authors.forename: Huma
authors.initials: H
authors.lastname: Changez
authors.affiliation: Professor and Consultant Microbiologist, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Smith
authors.affiliation: Consultant in Head and Neck Oncology, Oral and Maxillofacial Surgery Department, Southern General Hospital, Glasgow, United Kingdom.
authors.forename: Craig
authors.initials: C
authors.lastname: Wales
mesh_terms: D000038:Abscess / Q000382:microbiology; D000081:Acetamides / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000032:analysis*; D002481:Cellulitis / Q000382:microbiology*; D003731:Dental Caries / Q000382:microbiology; D005098:Exotoxins / Q000032:analysis*; D005145:Face / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000032:analysis*; D000069349:Linezolid; D008047:Lip Diseases / Q000382:microbiology; D008169:Lung Abscess / Q000382:microbiology; D008297:Male; D009333:Neck / Q000382:microbiology; D023303:Oxazolidinones / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000175:diagnosis*; D013211:Staphylococcus aureus / Q000472:pathogenicity*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; D023303:Oxazolidinones; C078284:Panton-Valentine leukocidin; D000069349:Linezolid