title: Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy.
abstract: The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6 MV X-Rays at low doses (0.4-2 Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2 Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Chemistry Department, Parma University, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Bedogni
authors.affiliation: Chemistry Department, Parma University, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bigi
authors.affiliation: Physics and Earth Science Department, Parma University, Parco Area delle Scienze 7/A, 43124 Parma, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Rimoldi
authors.affiliation: Physics and Earth Science Department, Parma University, Parco Area delle Scienze 7/A, 43124 Parma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cristofolini
authors.affiliation: Department of Clinical and Experimental Medicine, Parma University, via Gramsci 14, 43126 Parma (Italy).
authors.forename: S
authors.initials: S
authors.lastname: Pinelli
authors.affiliation: Department of Clinical and Experimental Medicine, Parma University, via Gramsci 14, 43126 Parma (Italy).
authors.forename: R
authors.initials: R
authors.lastname: Alinovi
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Negri
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: S C
authors.initials: SC
authors.lastname: Dhanabalan
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Attolini
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fabbri
authors.affiliation: Department of Clinical and Experimental Medicine, Parma University, via Gramsci 14, 43126 Parma (Italy).
authors.forename: M
authors.initials: M
authors.lastname: Goldoni
authors.affiliation: Department of Clinical and Experimental Medicine, Parma University, via Gramsci 14, 43126 Parma (Italy).
authors.forename: A
authors.initials: A
authors.lastname: Mutti
authors.affiliation: A.O.U. Parma Hospital, Department of Medical Physics, via Gramsci 14, 43126 Parma (Italy).
authors.forename: G
authors.initials: G
authors.lastname: Benecchi
authors.affiliation: A.O.U. Parma Hospital, Department of Medical Physics, via Gramsci 14, 43126 Parma (Italy).
authors.forename: C
authors.initials: C
authors.lastname: Ghetti
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iannotta
authors.affiliation: IMEM-CNR Institute, Parco Area delle Scienze 37/A, 43124 Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Salviati
mesh_terms: D017554:Carbon Compounds, Inorganic / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011166:Porphyrins / Q000737:chemistry*; D017655:Silicon Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D017554:Carbon Compounds, Inorganic; D017319:Photosensitizing Agents; D011166:Porphyrins; D017655:Silicon Compounds; D012822:Silicon Dioxide; C022088:silicon carbide