title: CD24 expression predicts poor prognosis for patients with cutaneous malignant melanoma.
abstract: Cutaneous malignant melanoma represents the major cause of mortality among skin cancers. Metastasis-associated protein CD24 is a small, heavily glycosylated cell surface protein that is overexpressed in various human malignancies. The present study was designed to determine the roles of CD24 in cutaneous malignant melanoma. The levels of CD24 mRNA and protein in cutaneous malignant melanoma tissues were detected by RT-PCR, Western blot and IHC. In patient samples, the levels of CD24 mRNA and protein were higher in cancer tissues than that in normal tissues. CD24 expression decreased the survival time of the patients with melanoma. Taken together, these results suggest that CD24 may be used as a new drug target for cutaneous malignant melanoma.
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: Ming-Rui
authors.initials: MR
authors.lastname: Tang
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Han
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: He-Huan
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Jin
keywords: CD24; melanoma; prognosis