title: Community respiratory virus infection in hematopoietic stem cell transplantation recipients and household member characteristics.
abstract: OBJECTIVE
  To determine if children or the number of contacts living in an immediate household increases the risk of community respiratory virus (CRV) acquisition in hematopoietic stem cell transplantation (HSCT) recipients.
  
  
  METHODS
  Retrospective, exploratory study.
  
  
  METHODS
  National Cancer Institute-designated comprehensive cancer center located in the Southeast.
  
  
  METHODS
  720 adult outpatients post-autologous or allogeneic HSCT.
  
  
  METHODS
  Data were gathered using a retrospective medical record review from July 1, 2006, to December 31, 2009. Summary statistics were used to describe sample characteristics. Binary logistic regression was used to determine whether the number of household member contacts or number of children in each age group was a significant predictor of CRV infection. Multivariate linear regression was used to investigate predictors of the number of CRV infections.
  
  
  METHODS
  The dependent variable was acquisition of CRV infection. Independent variables included the number of children in the household and the number of household members.
  
  
  RESULTS
  Across all HSCT recipients, children aged 0-4 years (p = 0.01) and 5-12 years (p = 0.001) predicted CRV infection. The allogeneic group had the greatest incidence of CRV infection and was most sensitive to the presence of young children. The total number of household members was not a predictor of CRV infection.
  
  
  CONCLUSIONS
  Households with children aged 12 years and younger more than doubled the risk of an HSCT recipient acquiring CRV infection. Additional studies are needed to test interventions designed to interrupt household transmission of CRV infection from children to vulnerable HSCT recipients.
  
  
  CONCLUSIONS
  Household contacts, particularly children, should be included in HSCT teaching. As indicated by the potentially high number of days from transplantation to acquisition of CRV infection, re-education and continuing focus on prevention of CRV infection should be reinforced throughout the lengthy transplantation period.
authors.affiliation: Moffitt Cancer Center and Research Institute (MCCRI), Tampa, FL.
authors.forename: Kay A
authors.initials: KA
authors.lastname: Sams
authors.affiliation: Department of Psychology, University of South Florida Sarasota-Manatee.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Reich
authors.affiliation: MCCRI.
authors.forename: Alice R
authors.initials: AR
authors.lastname: Boyington
authors.affiliation: MCCRI.
authors.forename: Elsa M
authors.initials: EM
authors.lastname: Barilec
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000821:virology; D005192:Family Health; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000821:virology*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D012189:Retrospective Studies
keywords: community respiratory virus; hematopoietic stem cell transplantation