title: Vaginal preparation with povidone iodine disinfection and saline douching as a safe and effective method in prevention of oocyte pickup-associated pelvic inflammation without spoiling the reproductive outcome: evidence from a large cohort study.
abstract: OBJECTIVE
  The aim of this study was to investigate if vaginal preparation procedure affects the occurrence of oocyte pickup-associated pelvic inflammation (OPU-PI) and the reproductive outcome in an in vitro fertilization (IVF) program.
  
  
  METHODS
  The occurrence of OPU-PI and the reproductive outcome were compared between 956 infertile patients undergoing vaginal preparation with saline douching alone versus 1,216 infertile patients undergoing a combination ofpovidone iodine disinfection and subsequent saline douching in an IVF program.
  
  
  RESULTS
  OPU-PI occurred in four patients (0.042%) in the saline douching alone group, whereas there were no cases in the combination group (p = 0.016). There were no significant differences in the rate of fertilization, morphologically good embryo acquisition, clinical and ongoing pregnancy between the two groups (p > 0.23).
  
  
  CONCLUSIONS
  This large cohort study demonstrated that a combination of vaginal povidone iodine disinfection and subsequent saline douching is more effective procedure than saline douching alone to prevent OPU-PI, without spoiling the oocyte quality.
authors.affiliation: IVF Center, Oak Clinic, Osaka, Japan. funabiki_m@oakclinic-group.com
authors.forename: M
authors.initials: M
authors.lastname: Funabiki
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: K
authors.initials: K
authors.lastname: Kitaya
authors.forename: Y
authors.initials: Y
authors.lastname: Iwaki
authors.forename: M
authors.initials: M
authors.lastname: Karita
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004203:Disinfection; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D054315:Oocyte Retrieval / Q000009:adverse effects*; D000292:Pelvic Inflammatory Disease / Q000517:prevention & control*; D011206:Povidone-Iodine / Q000494:pharmacology*; D011247:Pregnancy; D012965:Sodium Chloride; D007507:Therapeutic Irrigation; D014621:Vagina
chemical_list: D012965:Sodium Chloride; D011206:Povidone-Iodine