title: [Expression of Mus81 gene in Chinese Han patients with colorectal cancer and its clinical significance].
abstract: OBJECTIVE
  To explore the expression pattern of Mus81 gene in Chinese Han patients with colorectal cancer and analyze its correlation with the clinicopathological parameters and the tumor markers.
  
  
  METHODS
  Mus81 expression was detected using nested quantitative real-time PCR in the colorectal cancer tissues and corresponding adjacent normal tissues from 43 Chinese Han patients. The correlations of Mus81 expression profile with the clinicopathological parameters and common tumor markers were evaluated.
  
  
  RESULTS
  Mus81 expression level was significantly lower in the colorectal cancer tissues than in the corresponding adjacent normal tissues (114.6 ± 68.0 vs 202.5 ± 109.0, P<0.001). Of the 43 patients, 32 (74.4%) showed down-regulated Mus81 expression, which correlated significantly with distant metastasis (P=0.043), high TNM stage (P=0.022) and high P53 protein expression (P=0.011) of the tumor.
  
  
  CONCLUSIONS
  Down-regulation of Mus81 in colorectal cancer is correlated with tumor metastasis and progression, suggesting the value of Mus81 as a potential marker for colorectal cancer in Chinese Han patients.
authors.affiliation: Department of General Surgery, Guangzhou Red Cross Hospital/Fourth Affiliated Hospital of Medical School, Jinan University, Guangzhou 510220, China.E-mail: fan_woo@hotmail.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Weijia
authors.initials: W
authors.lastname: Chen
authors.forename: Guoqian
authors.initials: G
authors.lastname: Tan
authors.forename: Jianwei
authors.initials: J
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D015536:Down-Regulation; D004720:Endonucleases / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D004720:Endonucleases; C498772:MUS81 protein, human