title: Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.
abstract: This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for two days showed a significant increase in the activities of lysosomal enzymes (glucuronidase, N-acetyl glucosaminidase, galactosidase, cathepsin-B and cathepsin-D) were increased significantly in serum and the heart of ISO-induced rats, but the activities of glucuronidase and cathepsin-D were decreased significantly in the lysosomal fraction of the heart. Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats. Thus, phytic acid possesses a cardioprotective effect in ISO-induced MI in rats.
authors.affiliation: Department of Biotechnology, Muthaymmal College of Arts and Science , Rasipuram, Namakkal DT, Tamil Nadu , India and.
authors.forename: E
authors.initials: E
authors.lastname: Brindha
authors.forename: M
authors.initials: M
authors.lastname: Rajasekapandiyan
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002401:Cathepsin B / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism; D019610:Cytoprotection; D004195:Disease Models, Animal; D005696:Galactosidases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D007545:Isoproterenol; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010833:Phytic Acid / Q000494:pharmacology*; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000975:Antioxidants; D010833:Phytic Acid; D006867:Hydrolases; D005696:Galactosidases; D005966:Glucuronidase; D000118:Acetylglucosaminidase; D002401:Cathepsin B; C533916:Ctsb protein, rat; D002402:Cathepsin D; C533924:Ctsd protein, rat; D007545:Isoproterenol
keywords: Isoproterenol; lysosomal enzymes; myocardial infarction; phytic acid