title: Effect of continuous positive airway pressure on blood pressure in hypertensive patients with coronary artery bypass grafting and obstructive sleep apnea.
abstract: BACKGROUND
  Previous studies have documented that obstructive sleep apnea (OSA) increases the incidence of hypertension, respiratory failure and unexpected post-operative deaths during night in coronary artery bypass grafting (CABG) patients. We hypothesized that continuous positive airway pressure (CPAP) reduces blood pressure in these patients.
  
  
  METHODS
  We conducted a prospective, controlled study in 51 patients. The subjects received CPAP treatment were defined as CPAP group, whereas those refused to use CPAP were served as controls. Blood pressure was measured by 24 h ambulatory blood pressure at baseline and at six months.
  
  
  RESULTS
  Fifty-one patients completed the study. CPAP group and controls had similar characteristics. Compared with the control group, the 24-h SBP and 24-h DBP in the CPAP group had a tendency towards lower levels, but the differences were not statistically significant. But the change of SBP in CPAP treatment was significantly higher than controls (CPAP: 10.0 ± 13.5 mm Hg vs.
  
  
  METHODS
  2.9 ± 10.5 mm Hg, P = 0.040). The rate of hypertension control was improved in the CPAP treatment, but had no statistical difference compared to the controls (CPAP, 76.0% vs. CONTROL, 61.5%; P = 0.260). Compared with controls, the proportion of non-dipping hypertension had a markedly improvement in the CPAP group (CONTROL, 46.2% vs. CPAP, 16.0%; P = 0.034).
  
  
  CONCLUSIONS
  CPAP therapy decreased SBP and improved the status of non-dipping hypertension and alleviated daytime somnolence in hypertensive patients with CABG and OSA on standardized antihypertensive treatment. But DBP and hypertension control did not significantly change compared with the control group.
authors.affiliation: Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Harbin Medical University No. 37 Yiyuan Street, Nangang District, Harbin 150001, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Harbin Medical University No. 37 Yiyuan Street, Nangang District, Harbin 150001, China.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Harbin Medical University No. 37 Yiyuan Street, Nangang District, Harbin 150001, China.
authors.forename: Guoqian
authors.initials: G
authors.lastname: Wei
authors.affiliation: Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Harbin Medical University No. 37 Yiyuan Street, Nangang District, Harbin 150001, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cha
authors.affiliation: Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Harbin Medical University No. 37 Yiyuan Street, Nangang District, Harbin 150001, China.
authors.forename: Xueqi
authors.initials: X
authors.lastname: Li
keywords: Continuous positive airway pressure; coronary artery bypass grafting; hypertension; obstructive sleep apnea