title: Ingenol mebutate gel treatment for actinic cheilitis: report of four cases.
abstract: Actinic cheilitis (AC) are premalignant lesions that have an increased risk of malignant transformation. Their treatment, therefore, is essential to prevent carcinogenesis. However, optimal therapy is not well established and different modalities yield variable results. Ingenol mebutate gel has recently been approved by the US Food and Drug Administration for topical treatment of actinic keratosis, with high clearance rates. On the basis of these findings, we report our experience with this drug for the treatment of AC.
authors.affiliation: Department of Dermatology, Arnau de Vilanova Hospital, Valencia, Spain.
authors.forename: Nerea
authors.initials: N
authors.lastname: Barrado Solís
authors.forename: Paula
authors.initials: P
authors.lastname: Molés Poveda
authors.forename: César
authors.initials: C
authors.lastname: Lloret Ruiz
authors.forename: Virginia
authors.initials: V
authors.lastname: Pont Sanjuan
authors.forename: Manel
authors.initials: M
authors.lastname: Velasco Pastor
authors.forename: Esther
authors.initials: E
authors.lastname: Quecedo Estébanez
authors.forename: Javier
authors.initials: J
authors.lastname: Miquel Miquel
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002613:Cheilitis / Q000175:diagnosis / Q000188:drug therapy*; D004224:Diterpenes / Q000008:administration & dosage*; D005782:Gels; D006801:Humans; D008046:Lip / Q000187:drug effects* / Q000473:pathology; D008048:Lip Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C486592:3-ingenyl angelate; D000970:Antineoplastic Agents; D004224:Diterpenes; D005782:Gels
keywords: actinic cheilitis; field-directed therapy; ingenol mebutate gel