title: Childhood antecedents and risk for adult mental disorders.
abstract: Progress in treating and preventing mental disorders may follow from research that integrates development, genetics, and neuroscience. This review first delineates how longitudinal research has identified three particular groups of disorders shown to differ on the basis of symptom trajectories and risk-factor profiles. In the next section, the review describes how research on genetic contributions to psychopathology has elucidated the nature of risk for two groups of disorders, the neurodevelopmental and psychotic disorders. In the third section, the review describes how research on environmental contributions to psychopathology has targeted early temperament, its associated perturbations in information-processing functions, and its relations to a third group of disorders, the emotional disorders. For all three groups of disorders, such integrative research has generated ideas about novel interventions. The hope is that over the coming decade such ideas will lead to novel treatments that alter the trajectory of risk in developmental psychopathology.
authors.affiliation: Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892; email: daniel.pine@nih.gov.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Fox
mesh_terms: D001008:Anxiety Disorders / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D002648:Child; D002657:Child Development / Q000502:physiology*; D002659:Child Development Disorders, Pervasive / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D003866:Depressive Disorder / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D013694:Temperament / Q000502:physiology*
keywords: amygdala; anxiety; developmental psychopathology; prefrontal cortex