title: Pleura nodosum: fetal squamous debris in an unusual location.
abstract: We present a pathologic-radiologic case of a fetus with a right extralobar bronchopulmonary sequestration that required intervention in the form of a thoraco-amniotic shunt for management of a right pleural effusion. The intervention was successful in reducing the pleural effusion and the infant was born at 39 weeks gestational age but required some respiratory support for the 1st day of life. The pulmonary sequestration was excised on day 7 of life and demonstrated several small nodules on its pleural surface. Histologic examination demonstrated that the nodules consisted of granulomatous plaques containing squamous epithelium and hairs. The nodules are similar to those described in amnion nodosum, when the amniotic membrane incorporates fetal skin within the superficial tissue layers of the placenta in cases of oligohydramnios. To our knowledge, this is the 1st reported case of nodules containing amniotic fetal squamous debris to occur on lung visceral pleura.
authors.affiliation: 1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Linda
authors.initials: L
authors.lastname: Kocovski
authors.forename: Nina
authors.initials: N
authors.lastname: Stein
authors.forename: Jorge
authors.initials: J
authors.lastname: Arredondo
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000166:cytology*; D001706:Biopsy; D001998:Bronchopulmonary Sequestration / Q000175:diagnosis / Q000628:therapy*; D002404:Catheterization / Q000009:adverse effects*; D020878:Device Removal; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006197:Hair / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010994:Pleura / Q000473:pathology*; D010996:Pleural Effusion / Q000175:diagnosis / Q000628:therapy*; D011237:Predictive Value of Tests; D011247:Pregnancy; D014057:Tomography, X-Ray Computed; D016216:Ultrasonography, Prenatal
keywords: amnion nodosum; bronchopulmonary sequestration; radiography