title: Iron metabolism after application of modified magnetite nanoparticles in rats.
abstract: The influence of modified nanosized magnetite (NSM) particles (magnetic microspheres coated with chitosan and magnetoliposomes) after a single intravenous infusion of their suspensions on iron metabolism in rats has been studied. Modern physical and chemical methods (X-ray fluorescence, dynamic light scattering, transmission electron microscopy) were used for standardization of the modified NSM particles (their size, structure, ζ-potential, and concentration were determined). Atomic emission spectroscopy was used to reveal the dynamics of iron content in rat liver, spleen, lungs, and kidneys during 120 days. Colorimetric and immunoturbidimetric methods were used to determine the concentrations of plasma iron and the proteins involved in its metabolism - ceruloplasmin, transferrin, and ferritin. Their dynamics throughout the experiments were studied.
authors.affiliation: Siberian State Medical University, Tomsk, 634050, Russia. office@ssmu.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Milto
authors.forename: A Yu
authors.initials: AY
authors.lastname: Grishanova
authors.forename: T K
authors.initials: TK
authors.lastname: Klimenteva
authors.forename: I V
authors.initials: IV
authors.lastname: Suhodolo
authors.forename: G Yu
authors.initials: GY
authors.lastname: Vasukov
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanova
mesh_terms: D000818:Animals; D007501:Iron / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D051381:Rats; D013052:Spectrometry, X-Ray Emission; D013054:Spectrophotometry, Atomic; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D058185:Magnetite Nanoparticles; D007501:Iron