title: Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches.
abstract: The zebrafish has become a model to study adult vertebrate neurogenesis. In particular, the adult telencephalon has been an intensely studied structure in the zebrafish brain. Differential expression of transcriptional regulators (TRs) is a key feature of development and tissue homeostasis. Here we report an expression map of 1,202 TR genes in the telencephalon of adult zebrafish. Our results are summarized in a database with search and clustering functions to identify genes expressed in particular regions of the telencephalon. We classified 562 genes into 13 distinct patterns, including genes expressed in the proliferative zone. The remaining 640 genes displayed unique and complex patterns of expression and could thus not be grouped into distinct classes. The neurogenic ventricular regions express overlapping but distinct sets of TR genes, suggesting regional differences in the neurogenic niches in the telencephalon. In summary, the small telencephalon of the zebrafish shows a remarkable complexity in TR gene expression. The adult zebrafish telencephalon has become a model to study neurogenesis. We established the expression pattern of more than 1200 transcription regulators (TR) in the adult telencephalon. The neurogenic regions express overlapping but distinct sets of TR genes suggesting regional differences in the neurogenic potential.
authors.affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Campus Nord, Karlsruhe, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Diotel
authors.forename: Rebecca
authors.initials: R
authors.lastname: Rodriguez Viales
authors.forename: Olivier
authors.initials: O
authors.lastname: Armant
authors.forename: Martin
authors.initials: M
authors.lastname: März
authors.forename: Marco
authors.initials: M
authors.lastname: Ferg
authors.forename: Sepand
authors.initials: S
authors.lastname: Rastegar
authors.forename: Uwe
authors.initials: U
authors.lastname: Strähle
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001271:Atlases as Topic; D015870:Gene Expression; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D058953:Neural Stem Cells / Q000378:metabolism*; D013687:Telencephalon / Q000033:anatomy & histology / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D015027:Zebrafish / Q000033:anatomy & histology / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D029961:Zebrafish Proteins
keywords: adult neurogenesis; database; expression pattern; forebrain; transcription regulator; zebrafish