title: Determination of the content of residual solvents in muscone by head-space gas chromatography.
abstract: OBJECTIVE
  To explore the usefulness of a head-space gas chromatography in the determination of residual solvents including methanol,ethanol,ethyl ether,and petroleum ether in muscone in artificial musk.
  
  
  METHODS
  The head-space gas chromatography was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with a hydrogen flame ionization detector. The carrier gas was nitrogen and the solvent was dimethyl sulfoxide. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The containers of head-space injector were preheated at 80 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.
  
  
  RESULTS
  The results showed a good linear relationship for methanol,ethanol,ethyl ether,and petroleum ether(60-90 ℃)in the range of each consistency; and the limit of detection was 0.8,1.0,0.1,and 0.3 Μg/ml,respectively. The precision and average recoveries were satisfactory.
  
  
  CONCLUSIONS
  The head-space gas chromatography is simple,rapid,and precise technique for measuring residual solvents in muscone.
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Technology,Beijing Lianxin Pharmaceutic Co.,Ltd,Beijing 102628,China;3 Department of Technology,Hongjitang Pharmaceutical Co.,Ltd,Jinan 250012,China.
authors.forename: Ke-Min
authors.initials: KM
authors.lastname: Wang
authors.affiliation: Department of Natural Medicinal Chemistry,Institute of Materia Medica,CAMS and PUMC,Beijing 100050,China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Technology,Hongjitang Pharmaceutical Co.,Ltd,Jinan 250012,China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Lun
authors.affiliation: Department of Technology,Beijing Lianxin Pharmaceutic Co.,Ltd,Beijing 102628,China;3 Department of Technology,Hongjitang Pharmaceutical Co.,Ltd,Jinan 250012,China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
mesh_terms: D002849:Chromatography, Gas; D003516:Cycloparaffins / Q000737:chemistry*; D004340:Drug Contamination; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D000431:Ethanol / Q000032:analysis; D012997:Solvents / Q000032:analysis*
chemical_list: D003516:Cycloparaffins; D004365:Drugs, Chinese Herbal; D012997:Solvents; D000431:Ethanol; C031021:muscone