title: Dynamic 18F-FDOPA PET Findings After Carbidopa Premedication in 2 Adult Patients With Insulinoma-Related Hyperinsulinemic Hypoglycemia.
abstract: (18)F-fluorodihydroxyphenylalanine (FDOPA) PET seems to be of limited value to localize pancreatic insulin-secreting tumors in adult with hyperinsulinemic hypoglycemia. Carbidopa is an efficient inhibitor of the peripheral aromatic amino acid decarboxylase, significantly reducing the physiological pancreatic FDOPA uptake. Nevertheless, carbidopa effect on FDOPA uptake in insulinomas is not fully elucidated. No final consensus has been reached about the usefulness of carbidopa in patients with insulinoma-related hyperinsulinemic hypoglycemia. Moreover, the ideal timing for PET/CT acquisitions is a matter of discussion. We report the results of dynamic FDOPA PET performed after carbidopa premedication in 2 adult patients with insulinoma.
authors.affiliation: From the *Department of Biophysics and Nuclear Medicine, University Hospitals of Strasbourg; †ICube, UMR 7357 University of Strasbourg/CNRS and FMTS, Faculty of Medicine; Departments of ‡Diabetology, §Internal Medicine, Diabetes and Metabolic Disorders, and ∥Visceral Surgery and Transplantation, University Hospitals of Strasbourg, Strasbourg; and ¶Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
authors.forename: Thibault
authors.initials: T
authors.lastname: Bahougne
authors.forename: Bernard
authors.initials: B
authors.lastname: Goichot
authors.forename: Philippe
authors.initials: P
authors.lastname: Bachellier
authors.forename: David
authors.initials: D
authors.lastname: Taïeb
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
mesh_terms: D000328:Adult; D002230:Carbidopa; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000000981:diagnostic imaging*; D007003:Hypoglycemia / Q000150:complications / Q000000981:diagnostic imaging*; D007340:Insulinoma / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010190:Pancreatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D011292:Premedication; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D002230:Carbidopa