title: Oxidative stress and its significant roles in neurodegenerative diseases and cancer.
abstract: Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. mrsomchaip@yahoo.com.
authors.forename: Raynoo
authors.initials: R
authors.lastname: Thanan
authors.affiliation: Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. s-oikawa@doc.medic.mie-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Oikawa
authors.affiliation: Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. y-hiraku@doc.medic.mie-u.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hiraku
authors.affiliation: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. shiho-o@suzuka-u.ac.jp.
authors.forename: Shiho
authors.initials: S
authors.lastname: Ohnishi
authors.affiliation: Faculty of Nursing Science, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. maning@suzuka-u.ac.jp.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. mrsomchaip@yahoo.com.
authors.forename: Somchai
authors.initials: S
authors.lastname: Pinlaor
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. mrsomchaip@yahoo.com.
authors.forename: Puangrat
authors.initials: P
authors.lastname: Yongvanit
authors.affiliation: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. kawanisi@suzuka-u.ac.jp.
authors.forename: Shosuke
authors.initials: S
authors.lastname: Kawanishi
authors.affiliation: Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. mmurata@doc.medic.mie-u.ac.jp.
authors.forename: Mariko
authors.initials: M
authors.lastname: Murata
mesh_terms: D000818:Animals; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D018384:Oxidative Stress