title: Impact of IL-22 gene polymorphism on human immunodeficiency virus infection in Han Chinese patients.
abstract: OBJECTIVE
  To analyze the polymorphism of the IL-22 gene in Han Chinese patients and to evaluate the influence of IL-22 polymorphism on human immunodeficiency virus (HIV) infection.
  
  
  METHODS
  IL-22 gene polymorphism was analyzed in 73 blood samples from healthy participants. The influence of the genotype and allele distribution of three single nucleotide polymorphisms (rs2227484, rs2227485, and rs2227513) of IL-22 on HIV infection was evaluated in 619 HIV seropositive patients and 619 healthy controls. To determine the association between the rs2227513 genotype and IL-22 levels in plasma, we randomly selected 29 HIV seropositive blood samples and 15 healthy blood samples and measured the levels of IL-22.
  
  
  RESULTS
  Nine single nucleotide polymorphism loci of the IL-22 gene were found (rs2227484, rs2227485, rs2227491, rs2227508, rs2227513, rs1179249, rs1179250, rs1179251, and rs1182844). Stratified analysis (by sex) showed a higher association of HIV infection and the A/G genotype and G allele at rs2227513 in women, but not in men (A/G genotype odds ratio = 5.24, 95% confidence interval = 1.13-24.27; allele G odds ratio = 5.27, 95% confidence interval 1.15-24.23). The rs2227513 A/G genotype was also associated with significantly higher levels of plasma IL-22, regardless of whether the patient was HIV seropositive or seronegative.
  
  
  CONCLUSIONS
  Our results suggest that IL-22 production in blood might act as a pathogenic factor in HIV infection.
authors.affiliation: Department of Life Sciences, Sun Yat-Sen University, Guangzhou, China; Shenzhen Center for Disease Control and Prevention, Shenzhen, China; Department of Science in Botany, Jilin University, Changchun, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, China.
authors.forename: Guanglu
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yushu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Jinquan
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China. Electronic address: szhaojin@gmail.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address: 2353352460@qq.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000097:blood* / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D017422:Sequence Analysis, DNA; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22
keywords: HIV infection; Han Chinese; IL-22 gene polymorphism; haplotype