title: Protective action of green tea catechins in neuronal mitochondria during aging.
abstract: Mitochondria are central players in the regulation of cell homeostasis. They are essential for energy production but at the same time, reactive oxygen species accumulate as byproducts of the electron transport chain causing mitochondrial damage. In the central nervous system, senescence and neurodegeneration occur as a consequence of mitochondrial oxidative insults and impaired electron transfer. The accumulation of several oxidation products in neurons during aging prompts the idea that consumption of antioxidant compounds may delay neurodegenerative processes. Tea, one of the most consumed beverages in the world, presents benefits to human health that have been associated to its abundance in polyphenols, mainly catechins, that possess powerful antioxidant properties in vivo and in vitro. In this review, the focus will be placed on the effects of green tea catechins in neuronal mitochondria. Although these compounds reach the brain in small quantities, there are several possible targets, signaling pathways and molecular machinery impinging in the mitochondria that will be highlighted. Accumulated evidence thus far seems to indicate that catechins help prevent neurodegeneration and delay brain function decline.
authors.affiliation: Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
authors.forename: Marco
authors.initials: M
authors.lastname: Assuncao
authors.affiliation: Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
authors.forename: Jose Paulo
authors.initials: JP
authors.lastname: Andrade
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*
chemical_list: D018696:Neuroprotective Agents; D013662:Tea; D002392:Catechin