title: Understanding the functional discrepancy of Pim-1 in cancer.
abstract: The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Allal
authors.initials: A
authors.lastname: Ouhtit
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Sukalp
authors.initials: S
authors.lastname: Muzumdar
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Ishita
authors.initials: I
authors.lastname: Gupta
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Somya
authors.initials: S
authors.lastname: Shanmuganathan
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Tamimi
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000201:enzymology / Q000209:etiology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000209:etiology*; D051573:Proto-Oncogene Proteins c-pim-1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D051573:Proto-Oncogene Proteins c-pim-1