title: Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese rats.
abstract: The percentage of overweight and obese person has increased markedly since several decays. Obesity is associated with increased risked factor for many diseases such as, diabetes, heart complications, arthritis and certain types of cancer. Feeding behavior is in controlled by a major interaction between central nervous system and many organs of the body. The role of serotonin (5-HT) in feeding behavior is well recognized. The aim of present study was to evaluate the effect of Anethum graveolens seeds aqueous extract (AGAE) on food intake, body weight and serotonin metabolism in over weight rats. Five weeks oral administration of AGAE shows significant decrease in body weight, food intake and significant increase in whole brain 5-HT, 5-HIAA and tryptophan level in brain and plasma of experimental animals. Increased level of 5-HT induced satiety and suppressed food intake and result is the reduction in body weight.
authors.affiliation: Department of Biochemistry, Sir Syed College of Medical Sciences, Karachi, Pakistan.
authors.forename: Farhat
authors.initials: F
authors.lastname: Bano
authors.affiliation: Karachi Medical and Dental Collage, Karachi, Pakistan.
authors.forename: Afrinah
authors.initials: A
authors.lastname: Ahmed
authors.affiliation: epartment of Pharmacognosy, Federal Urdu University of Arts, Sciences & Technology, Karachi, Pakistan.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Tahira
authors.initials: T
authors.lastname: Parveen
mesh_terms: D000284:Administration, Oral; D028524:Anethum graveolens / Q000737:chemistry; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D017208:Rats, Wistar; D012639:Seeds; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid