title: Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field.
abstract: Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle. Among 624532 SNP after quality control, we found that 11 SNPs on 3 chromosomes (chr17, 22, and 15) were significantly associated with the trait at the p.adjust <0.05 after PERMORY test. Most significantly associated SNPs were located on chromosome 17, around the genes Myosin XVIIIB and Seizure related 6 homolog (mouse)-like, which were associated with lung cancer. Based on the known function of the genes nearby the significant SNPs, the FMD resistant animals might have ability to improve their innate immune response to FMDV infection.
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Kwang-Nyeong
authors.initials: KN
authors.lastname: Lee
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Taeheon
authors.initials: T
authors.lastname: Lee
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Jong-Hyeon
authors.initials: JH
authors.lastname: Park
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Su-Mi
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Hyang-Sim
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Gangwon Veterinary Service Laboratory, Chuncheon 220-822, Korea .
authors.forename: Dong-Su
authors.initials: DS
authors.lastname: Chung
authors.affiliation: Gyeonggido Veterinary Service, Suwon 441-460, Korea .
authors.forename: Hang-Sub
authors.initials: HS
authors.lastname: Shim
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong 456-749, Korea .
authors.forename: Hak-Kyo
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Anyang 430-757, Korea .
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
keywords: Bovine Single Nucleotide Polymorphism Chip; Foot-and-mouth Disease; Genome-wide Association Study [GWAS]; Holstein