title: Effect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological study.
abstract: OBJECTIVE
  This study investigated the effect of Ginkgo biloba (GB) on brain volume in cerebral ischemia induced by stopping carotid artery blood flow.
  
  
  METHODS
  Twenty-four adult male rats were divided into 4 groups of 6 rats each. No procedure was performed on the control group. Ischemia was applied to the rats in the ischemia and ischemia + GB groups by clamping the arteria carotis communis for 30 min. The rats in the ischemia + GB group were given 100 mg/kg drops (Tebokan Fort Drop, Abdi Ibrahim Ilaç Sanayi A.$., Turkey) containing dry GB leaf extract orally, every day for 14 days from the day of ischemia. In the sham group, surgical stress alone was applied by performing a skin incision. On the 14th day, brain tissues were extracted and evaluated stereologically and histopathologically.
  
  
  RESULTS
  The only statistically significant difference was observed between the sham and control groups.
  
  
  CONCLUSIONS
  This result may be interpreted as surgical stress, established by cutaneous incision, having an adverse effect on brain volume. Additionally, the absence of any difference in terms of brain volume following 30 min of ischemia between the ischemia and control groups suggests that a probable postischemic rise in brain volume disappears within 14 days.
authors.affiliation: Department of Histology and Embryology, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Aktürk
authors.forename: Ersan
authors.initials: E
authors.lastname: Odaci
authors.forename: Ayşe
authors.initials: A
authors.lastname: Ikinci
authors.forename: Orhan
authors.initials: O
authors.lastname: Baş
authors.forename: Sinan
authors.initials: S
authors.lastname: Canpolat
authors.forename: Serdar
authors.initials: S
authors.lastname: Colakoğlu
authors.forename: Osman Fikret
authors.initials: OF
authors.lastname: Sönmez
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002340:Carotid Artery Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D020441:Ginkgo biloba; D008297:Male; D009929:Organ Size; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000096983:Ginkgo Extract
chemical_list: D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract