title: X-ray repair cross-complementing gene 1 Arg399Gln polymorphism and glioma risk among Asians: A meta-analysis based on 2 326 cases and 3 610 controls.
abstract: OBJECTIVE
  Previous reports have demonstrated that X-ray repair cross-complementing gene 1 (XRCC1) Arg399Gln polymorphism is a possible risk factor for several cancers. Published data on the association of XRCC1 Arg399Gln polymorphism with glioma susceptibility have generated conflicting results. This study is designed to precisely estimate the relationship.
  
  
  METHODS
  A computer-based online retrieval of Medline, EMBASE, OVID, Sciencedirect, and Chinese National Knowledge Infrastructure was performed to search papers regarding association of XRCC1 Arg399Gln polymorphisms with glioma published up to April 2012.
  
  
  METHODS
  Two investigators selected data independently. Meta analysis was then performed for the selected studies using STATA 11.0 software after strict selection. Heterogeneity test, sensitivity analysis and publication bias assessments were then conducted.
  
  
  METHODS
  Association of XRCC1 Arg399Gln polymorphism with glioma risk.
  
  
  RESULTS
  A total of nine case-controlled studies comprising 2 326 cases and 3 610 controls were selected for final analysis. The overall data failed to indicate a significant association of XRCC1 Arg399Gln polymorphism with glioma risk (Gln/Gln vs. Arg/Arg: odds ratio (OR) = 1.11; 95% confidence interval (CI) = 0.94-1.31; dominant model: OR = 1.06; 95%CI = 0.95-1.18; recessive model: OR = 1.04; 95%CI = 0.81-1.34). However, subgroup analysis regarding ethnicity showed an increased risk among Asians (Gln/Gln vs. Arg/Arg: OR = 1.70; 95%CI = 1.17-2.46; dominant model: OR = 1.40; 95%CI = 1.10-1.78; recessive model: OR = 1.46; 95%CI = 1.04-2.05) but not Caucasians or mixed ethnicities.
  
  
  CONCLUSIONS
  XRCC1 Arg399Gln polymorphism might modify the susceptibility to glioma among Asians but not Caucasians. Further large and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University of Chinese PLA, Chongqing 400037, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University of Chinese PLA, Chongqing 400037, China.
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University of Chinese PLA, Chongqing 400037, China.
authors.forename: Jiaohua
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University of Chinese PLA, Chongqing 400037, China.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Shu
keywords: XRCC1 Arg399Gln; case-controlled study; database; genetic association; glioma; malignancy; meta analysis; polymorphism; risk; susceptibility; variation