title: Influence of body composition on survival in patients with head and neck cancer.
abstract: Recent evidence has suggested links between obesity and outcomes for various types of cancer. This study investigates the impact that body composition has on survival in patients with head and neck cancer.
  
  
  
  Data prospectively collected from 578 patients were analyzed using Cox regression models to determine independent associations that pretreatment body mass index (BMI) and 3-month weight change have on observed survival.
  
  
  
  Higher BMIs were associated with better survival (p < .001). Five-year rates ranged from 33.8% for underweight to 75.3% for overweight/obese patients. Patients with stable weight had the highest 5-year rate (72.6%; p = .019), whereas patients who gained ≥5% had worse survival (45.8%) than those who lost ≥5% (65.8%). BMI independently predicted survival, whereas weight change was not an independent predictor.
  
  
  
  This demonstrated association between BMI and survival provides useful information when offering prognoses and investigating optimal treatments © 2015 Wiley Periodicals, Inc. Head Neck 38: E261-E267, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa.
authors.forename: Lucy Hynds
authors.initials: LH
authors.lastname: Karnell
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Sperry
authors.affiliation: Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa.
authors.forename: Carryn M
authors.initials: CM
authors.lastname: Anderson
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa.
authors.forename: Nitin A
authors.initials: NA
authors.lastname: Pagedar
mesh_terms: D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D006258:Head and Neck Neoplasms / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D016019:Survival Analysis
keywords: body composition; body mass index; head and neck cancer; survival; weight change; weight loss