title: Monkey models of tuberculosis: lessons learned.
abstract: The use of animal models has been invaluable for studying the pathogenesis of Mycobacterium tuberculosis infection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.
authors.affiliation: Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Juliet C
authors.initials: JC
authors.lastname: Peña
authors.affiliation: Animal Biosafety Level III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA wenzheho@temple.edu.
authors.forename: Wen-Zhe
authors.initials: WZ
authors.lastname: Ho
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D055985:Latent Tuberculosis / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control* / Q000662:veterinary*; D008252:Macaca fascicularis / Q000276:immunology* / Q000821:virology; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013045:Species Specificity; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000266:history; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control* / Q000662:veterinary*
chemical_list: D032581:Tuberculosis Vaccines