title: Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy.
abstract: By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5/PEG nanocomposites. The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5/PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5/PEG and the following 808-nm laser irradiation (0.5 W/cm(2)). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5/PEG in mice after treatment. These results indicate potential application of GO/BaGdF5/PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. Electronic address: wuhuixia@shnu.edu.cn.
authors.forename: Huixia
authors.initials: H
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College & Center for Biomedical Imaging, Fudan University, Shanghai 200032, China.
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. Electronic address: shipingy@shnu.edu.cn.
authors.forename: Shiping
authors.initials: S
authors.lastname: Yang
mesh_terms: D000818:Animals; D001464:Barium / Q000494:pharmacology*; D017609:Barium Compounds / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology*; D005682:Gadolinium / Q000494:pharmacology; D006108:Graphite / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology; D010087:Oxides / Q000494:pharmacology*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared; D014057:Tomography, X-Ray Computed; D014961:X-Ray Diffraction
chemical_list: D017609:Barium Compounds; D010087:Oxides; D012996:Solutions; D001464:Barium; D011092:Polyethylene Glycols; D006108:Graphite; D005682:Gadolinium; D005459:Fluorides
keywords: BaGdF(5); Graphene oxide; Magnetic resonance imaging; Photothermal therapy; X-ray computed tomography imaging