title: Effect of integrated cognitive therapy on hippocampal functional connectivity patterns in stroke patients with cognitive dysfunction: a resting-state FMRI study.
abstract: Objective. This study aimed to identify abnormal hippocampal functional connectivity (FC) following ischemic stroke using resting-state fMRI. We also explored whether abnormal hippocampal FC could be modulated by integrated cognitive therapy and tested whether these alterations were associated with cognitive performance. Methods. 18 right-handed cognitively impaired ischemic stroke patients and 18 healty control (HC) subjects were included in this study. Stroke subjects were scanned at baseline and after integrated cognitive therapy, while HCs were only scanned at baseline, to identify regions that show significant correlations with the seed region. Behavioral and cognitive assessments were obtained before each scan. Results. During the resting state, we found abnormal hippocampal FC associated with temporal regions, insular cortex, cerebellum, and prefrontal cortex in stroke patients compared to HCs. After integrated cognitive therapy, however, the stroke group showed increased hippocampal FC mainly located in the prefrontal gyrus and the default mode network (DMN). Altered hippocampal FC was associated with cognitive improvement. Conclusion. Resting-state fMRI may provide novel insight into the study of functional networks in the brain after stroke. Furthermore, altered hippocampal FC may be a compensatory mechanism for cognitive recovery after ischemic stroke.
authors.affiliation: Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fujian 350003, China.
authors.forename: Shanli
authors.initials: S
authors.lastname: Yang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350108, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350108, China.
authors.forename: Haicheng
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fujian 350003, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tao
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350108, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fujian 350003, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fujian 350003, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Fujian University of Traditional Chinese Medicine, 1 Huatuo Road, Minhou Shangjie, Fuzhou, Fujian 350108, China.
authors.forename: Lidian
authors.initials: L
authors.lastname: Chen