title: Effects of Sustained Lung Inflation, a lung recruitment maneuver in primary acute respiratory distress syndrome, in respiratory and cerebral outcomes in preterm infants.
abstract: BACKGROUND
  Sustained Lung Inflation (SLI) is a maneuver of lung recruitment in preterm newborns at birth that can facilitate the achieving of larger inflation volumes, leading to the clearance of lung fluid and formation of functional residual capacity (FRC).
  
  
  OBJECTIVE
  To investigate if Sustained Lung Inflation (SLI) reduces the need of invasive procedures and iatrogenic risks.
  
  
  METHODS
  78 newborns (gestational age≤34 weeks, weighing≤2000 g) who didn't breathe adequately at birth and needed to receive SLI in addition to other resuscitation maneuvers (2010 guidelines).
  
  
  METHODS
  78 preterm infants born one after the other in our department of Neonatology of Catania University from 2010 to 2012.
  
  
  METHODS
  The need of intubation and surfactant, the ventilation required, radiological signs, the incidence of intraventricular hemorrhage (IVH), periventricular leukomalacia, retinopathy in prematurity from III to IV plus grades, bronchopulmonary dysplasia, patent ductus arteriosus, pneumothorax and necrotizing enterocolitis.
  
  
  RESULTS
  In the SLI group infants needed less intubation in the delivery room (6% vs 21%; p<0.01), less invasive mechanical ventilation (14% vs 55%; p≤0.001) and shorter duration of ventilation (9.1 days vs 13.8 days; p≤0.001). There wasn't any difference for nasal continuous positive airway pressure (82% vs 77%; p=0.43); but there was less surfactant administration (54% vs 85%; p≤0.001) and more infants received INSURE (40% vs 29%; p=0.17). We didn't found any differences in the outcomes, except for more mild intraventricular hemorrhage in the SLI group (23% vs 14%; p=0.15; OR=1.83).
  
  
  CONCLUSIONS
  SLI is easier to perform even with a single operator, it reduces the necessity of more complicated maneuvers and surfactant without statistically evident adverse effects.
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Grasso
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Sciacca
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Giacchi
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Carpinato
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Mattia
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy.
authors.forename: Grazia Maria
authors.initials: GM
authors.lastname: Palano
authors.affiliation: Department of Pediatrics, Neonatology, NICU, University of Catania, "Policlinico of Catania", Italy. Electronic address: mlbetta@yahoo.it.
authors.forename: Pasqua
authors.initials: P
authors.lastname: Betta
mesh_terms: D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002657:Child Development; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D012121:Respiration, Artificial / Q000009:adverse effects*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
keywords: Iatrogenic risks; Neonatal resuscitation; Pulmonary recruitment maneuvers; Surfactant; Sustained