title: Dormant Cells: The Original Cause of Tumor Recurrence and Metastasis.
abstract: Tumor dormancy is one of the stages in tumor development without clinical symptoms. Tumor dormant cells may appear in early stages of tumor development, as well as in micrometastasis and minimal residual disease. The mechanism for the switch of dormant cells between quiescent and proliferative stages is still largely unknown. Potential mechanisms that may account for the transition between dormant tumor cells and proliferative cells include angiogenesis, immune response, cellular factors, and signaling pathways. The clinical and therapeutic importance of dormant cells requires further studies to provide therapeutic strategies for inhibition of metastasis and tumor recurrence.
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Nanjing University School of Medicine, Nanjing, China.
authors.forename: Enze
authors.initials: E
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Weinberg College of Arts and Sciences at Northwestern University, Evanston, IL, USA.
authors.forename: Anna Junjie
authors.initials: AJ
authors.lastname: Shangguan
authors.affiliation: Changzhou TCM Hospital, Changzhou, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China. zhh_fish@126.com.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
keywords: Cell cycle; Dormant cells; Metastasis; Tumor; Tumor recurrence