title: Progress on Developing Adaptive Optics-Optical Coherence Tomography forIn VivoRetinal Imaging: Monitoring and Correction of Eye Motion Artifacts.
abstract: Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality ofin vivoimages of cellular structures in the human retina. Here, we present a short review of progress on developing AO-OCT instruments. Despite significant progress in imaging speed and resolution, eye movements present during acquisition of a retinal image with OCT introduce motion artifacts into the image, complicating analysis and registration. This effect is especially pronounced in high-resolution datasets acquired with AO-OCT instruments. Several retinal tracking systems have been introduced to correct retinal motion during data acquisition. We present a method for correcting motion artifacts in AO-OCT volume data after acquisition using simultaneously captured adaptive optics-scanning laser ophthalmoscope (AO-SLO) images. We extract transverse eye motion data from the AO-SLO images, assign a motion adjustment vector to each AO-OCTA-scan, and re-sample from the scattered data back onto a regular grid. The corrected volume data improve the accuracy of quantitative analyses of microscopic structures.
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratroy (VSRI), Department of Ophthalmology and Vision Science, and Department of Cell Biology and Human Anatomy, University of California Davis, Sacramento, CA 95817 USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory (VSRI), Department of Ophthalmology and Vision Science, with the Institute for Data Analysis and Visualization (IDAV), Department of Computer Science, University of California, Davis, Davis, CA 95616 USA, and also with Physical and Life Sciences, Lawrence Livermore National Laboratory, CA 94551 USA.
authors.forename: Arlie G
authors.initials: AG
authors.lastname: Capps
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratroy (VSRI), Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817 USA.
authors.forename: Dae Yu
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratroy (VSRI), Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817 USA.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Panorgias
authors.affiliation: College of Optometry, University of Houston, Houston, TX 77204 USA.
authors.forename: Scott B
authors.initials: SB
authors.lastname: Stevenson
authors.affiliation: Institute for Data Analysis and Visualization (IDAV), Department of Computer Science, University of California, Davis, CA 95616-8562 USA.
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamann
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratroy (VSRI), Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817 USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Werner
keywords: Aberration compensation; adaptive optics; imaging system; motion artifact correction; ophthalmology; optical coherence tomography; scanning laser ophthalmoscopy