title: Regulation of herpesvirus reactivation by host microRNAs.
abstract: The interplay between latent and lytic modes of infection is central to successful infection of all herpesviruses, yet knowledge of the determinants that govern reactivation of these viruses from latent to lytic infection is limited. Recently, several studies have identified roles for specific cellular microRNAs in inhibiting reactivation of various herpesviruses, thereby promoting latent infections. These studies are discussed in the context of current knowledge on mechanisms of regulation of reactivation of specific herpesviruses.
authors.affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Canada lori.frappier@utoronto.ca.
authors.forename: Lori
authors.initials: L
authors.lastname: Frappier
mesh_terms: D015967:Gene Expression Regulation, Viral; D006564:Herpesviridae / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D014775:Virus Activation
chemical_list: D035683:MicroRNAs