title: Acute cardiac sympathetic disruption and left ventricular wall motion abnormality in takotsubo syndrome.
abstract: Takotsubo syndrome (TS) is characterized by a unique pattern of transient circumferential left ventricular wall motion abnormality (LVWMA). The LVWMA in TS may be localized to the apical, mid-apical, mid-ventricular, mid-basal or basal regions of the left ventricle. Focal and generialized (global) LVWMA have also been reported. In the acute phase of TS, the hyperkinetic valve-like motion of the basal segments and/or the hyperkinetic slingshot-like motion of the apical segments combined with the firm stunned a-, hypokinetic segments result in a conspicuous left ventricular ballooning during systole. The LVWMA in TS follows most probably the local cardiac sympathetic nerve distribution and caused by local cardiac sympathetic disruption and noradrenaline spillover.
authors.affiliation: Department of Cardiology, Karolinska University Hospital-Huddinge , Stockholm , Sweden.
authors.forename: Shams
authors.initials: S
authors.lastname: Y-Hassan
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D018805:Sepsis / Q000150:complications*; D054549:Takotsubo Cardiomyopathy / Q000209:etiology*
keywords: Sepsis; broken heart syndrome; heart failure; myocardial infarction; neurogenic stunned myocardium; takotsubo