title: Effect of an Olive Oil-Based Lipid Emulsion Compared With a Soybean Oil-Based Lipid Emulsion on Liver Chemistry and Bile Acid Composition in Preterm Infants Receiving Parenteral Nutrition: A Double-Blind, Randomized Trial.
abstract: The pathogenesis of parenteral nutrition (PN)-associated liver dysfunction is multifactorial. Lipid emulsions may be one of the putative mechanisms. Our aim was to comparatively assess the effect of parenteral olive oil- and soybean oil-based lipid emulsions on liver chemistry and bile acid composition in preterm infants.
  
  
  
  We performed a double-blind, randomized clinical study in which 103 preterm infants were randomly assigned to PN using either soybean oil-based lipid emulsion (SO; n = 51) or olive oil (OO)-based lipid emulsion (OO; n = 52). The primary end point was liver chemistry. The secondary end point was the plasma bile acid composition.
  
  
  
  One hundred infants completed this study. In the SO group, the serum direct bilirubin was significantly higher after PN for 7 days compared with the OO group. Bile acids increased over time in both treatment groups. However, specific differences in the change in bile acid composition over time were noted between groups.
  
  
  
  Differences in direct bilirubin and bile acid composition were observed over time between the 2 groups. Considering the long-term use of lipid emulsions in higher risk babies, these findings might be useful for understanding the pathogenesis of PN-associated liver dysfunction.
authors.affiliation: Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China Shanghai Institute of Pediatric Research, Shanghai, China.
authors.forename: Ke-Jun
authors.initials: KJ
authors.lastname: Zhou
authors.affiliation: Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
authors.forename: Qing-Ya
authors.initials: QY
authors.lastname: Tang
authors.affiliation: Department of Clinical Nutrition, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Clinical Nutrition, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Lu
authors.affiliation: Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Wang
authors.affiliation: Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China Shanghai Institute of Pediatric Research, Shanghai, China caiw1978@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry*; D002779:Cholestasis / Q000209:etiology; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D008099:Liver / Q000737:chemistry*; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D000069463:Olive Oil; D010288:Parenteral Nutrition / Q000009:adverse effects* / Q000379:methods; D013024:Soybean Oil
chemical_list: D001647:Bile Acids and Salts; D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D013024:Soybean Oil
keywords: bile acid; lipid emulsion; liver chemistry; olive oil; parenteral nutrition