title: Clinical and diagnostic features and treatment of giardiasis.
abstract: Giardia is the most common causes of protozoan diarrhea that lead to significant morbidity and mortality worldwide. Giardiasis can be cause of disturbance of host immune response. The treatment of Giardiasis is unsuccessful in some cases. The purpose of this study was to determine the clinical features and the content of secretory immunoglobulin A (sIgA) among adults and to evaluate efficiency of new plant preparation "Sausalin". The clinical studies were conducted in Karaganda Regional Infection Hospital (Kazakhstan). 250 patients with giardiasis were randomly assigned to receive sausalin at a dose 720 mg/day or ornidazole at 1500 mg/day. Clinical symptoms of giardisis and efficiency of treatment were evaluated. Protozoal clearance rate and clinical symptoms were assessed. Stool samples were collected from 40 patients and examined the content of sIgA. Our study found the prevalence of abdominal pain, dyspeptic syndrome and the symptoms of intoxication in patients with giardiasis. The increase the level of sIgA was detected, especially in females (88 mg/l). Sausalin was more effectiveness than ornidazole. After the treatment, the clearance rate of giardia (85.71% vs. 42.19%; P<0.05) and the clinical efficacy were significantly higher in the sausalin-treated group than in the ornidazole-treated group. The features of clinic manifestations of giardiasis were identified in population of Kazakhstan. Our data suggest the higher level of sIgA was significantly associated with features of clinic manifestations that the participant had. Treatment with sausalin was more effective than treatment with ornidazole. Further research is needed to explain the existence relationship between Giardia infection and host immune response.
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Begaydorova
authors.forename: G E
authors.initials: GE
authors.lastname: Nasakaeva
authors.forename: S I
authors.initials: SI
authors.lastname: Tabagari
authors.forename: E A
authors.initials: EA
authors.lastname: Iukhnevich
authors.forename: G K
authors.initials: GK
authors.lastname: Alshinbekova
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D005260:Female; D005873:Giardiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology*; D006801:Humans; D007623:Kazakhstan; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D009950:Ornidazole / Q000008:administration & dosage*; D015995:Prevalence
chemical_list: D008795:Metronidazole; D009950:Ornidazole