title: Strain-dependent performance in nicotine-induced conditioned place preference.
abstract: Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine's rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42%-57%). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.
authors.affiliation: Department of Psychology, Neuroscience Program, Temple University.
authors.forename: Munir G
authors.initials: MG
authors.lastname: Kutlu
authors.affiliation: Department of Psychology, Neuroscience Program, Temple University.
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: Ortega
authors.affiliation: Department of Psychology, Neuroscience Program, Temple University.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Gould
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D058999:Drug-Seeking Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009538:Nicotine / Q000494:pharmacology*; D013045:Species Specificity; D014029:Tobacco Use Disorder / Q000235:genetics*
chemical_list: D009538:Nicotine