title: Clinical evaluation of various thyroid hormones on thyroid function.
abstract: To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P < 0.01), and the R-values were -0.065 and -0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and the R-values were -0.241, -0.225, -0.195, and -0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and the R-values were -0.322, -0.262, -0.179, and -0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Hong
authors.identifier: 0000-0002-5096-9253
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Xiaolan
authors.identifier: 0000-0002-7077-5253
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Chunyan
authors.identifier: 0000-0001-5782-1887
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Le
authors.initials: L
authors.lastname: Bu
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Manna
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Qu