title: ELF3 controls thermoresponsive growth in Arabidopsis.
abstract: Plant development is highly responsive to ambient temperature, and this trait has been linked to the ability of plants to adapt to climate change. The mechanisms by which natural populations modulate their thermoresponsiveness are not known. To address this, we surveyed Arabidopsis accessions for variation in thermal responsiveness of elongation growth and mapped the corresponding loci. We find that the transcriptional regulator EARLY FLOWERING3 (ELF3) controls elongation growth in response to temperature. Through a combination of modeling and experiments, we show that high temperature relieves the gating of growth at night, highlighting the importance of temperature-dependent repressors of growth. ELF3 gating of transcriptional targets responds rapidly and reversibly to changes in temperature. We show that the binding of ELF3 to target promoters is temperature dependent, suggesting a mechanism where temperature directly controls ELF3 activity.
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: Mathew S
authors.initials: MS
authors.lastname: Box
authors.affiliation: Computational Informatics, CSIRO, Dutton Park, QLD 4012, Australia.
authors.forename: B Emma
authors.initials: BE
authors.lastname: Huang
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: Mirela
authors.initials: M
authors.lastname: Domijan
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: Katja E
authors.initials: KE
authors.lastname: Jaeger
authors.affiliation: Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK; School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
authors.forename: Asif Khan
authors.initials: AK
authors.lastname: Khattak
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: Seong Jeon
authors.initials: SJ
authors.lastname: Yoo
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Sedivy
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: D Marc
authors.initials: DM
authors.lastname: Jones
authors.affiliation: Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Hearn
authors.affiliation: Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
authors.forename: Alex A R
authors.initials: AAR
authors.lastname: Webb
authors.affiliation: School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
authors.forename: Alastair
authors.initials: A
authors.lastname: Grant
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
authors.forename: James C W
authors.initials: JCW
authors.lastname: Locke
authors.affiliation: The Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK. Electronic address: philip.wigge@slcu.cam.ac.uk.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Wigge
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002940:Circadian Rhythm; D018506:Gene Expression Regulation, Plant; D006358:Hot Temperature; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D014157:Transcription Factors; C432430:At2g25930 protein, Arabidopsis