title: Serotype 10A in case patients with invasive pneumococcal disease: a pilot study of PCR-based serotyping in New Jersey.
abstract: In 2008, the New Jersey Department of Health (NJDOH) identified a 21.1% increase in reported invasive pneumococcal disease (IPD). In 2009, NJDOH piloted nucleic acid-based serotyping to characterize serotypes causing IPD. From April through September, NJDOH received specimens from 149 of 302 (49%) case patients meeting our case definition. An uncommon serotype, 10A, accounted for 25.2% of IPD overall and was identified in 12 counties, but it was associated with one county (rate ratio = 5.4, 95% confidence interval [CI] 2.1, 11.8). NJDOH subsequently conducted a case-control study to assess the presentation of and clinical risk factors for 10A IPD. Case patients with 10A IPD were more likely to have had immunosuppression, asthma, and multiple chronic medical conditions than control subjects had (odds ratio [OR] = 2.6, 95% CI 1.1, 6.3; OR=4.7, 95% CI 1.7, 13.2; and OR=2.3, 95% CI 1.0, 5.2, respectively). State-based pneumococcal serotype testing identified an uncommon serotype in New Jersey. Continued pneumococcal serotype surveillance might help the NJDOH identify and respond to future serotype-specific increases.
authors.affiliation: Council of State and Territorial Epidemiologists, Applied Epidemiology Fellowship, Atlanta, GA ; New Jersey Department of Health, Office of the State Epidemiologist/Environmental and Occupational Health Services, Communicable Disease Service, Trenton, NJ ; Johns Hopkins University, School of Medicine, Division of General Internal Medicine, Baltimore, MD.
authors.forename: Samantha I
authors.initials: SI
authors.lastname: Pitts
authors.affiliation: New Jersey Department of Health, Office of the State Epidemiologist/Environmental and Occupational Health Services, Communicable Disease Service, Trenton, NJ ; Centers for Disease Control and Prevention, Epidemic Intelligence Service, Atlanta, GA.
authors.forename: Andria
authors.initials: A
authors.lastname: Apostolou
authors.affiliation: New Jersey Department of Health, Office of the State Epidemiologist/Environmental and Occupational Health Services, Communicable Disease Service, Trenton, NJ.
authors.forename: Sarmila
authors.initials: S
authors.lastname: DasGupta
authors.affiliation: New Jersey Department of Health, Division of Public Health Infrastructure and Emergency Preparedness, Public Health and Environmental Laboratories, Trenton, NJ.
authors.forename: Nelson
authors.initials: N
authors.lastname: Delgado
authors.affiliation: New Jersey Department of Health, Division of Public Health Infrastructure and Emergency Preparedness, Public Health and Environmental Laboratories, Trenton, NJ ; Rutgers University, Robert Wood Johnson Medical School, Department of Pathology & Laboratory Medicine, New Brunswick, NJ.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kirn
authors.affiliation: New Jersey Department of Health, Office of the State Epidemiologist/Environmental and Occupational Health Services, Communicable Disease Service, Trenton, NJ.
authors.forename: Barbara
authors.initials: B
authors.lastname: Montana
authors.affiliation: New Jersey Department of Health, Division of Epidemiology, Environmental and Occupational Health, Trenton, NJ.
authors.forename: Christina
authors.initials: C
authors.lastname: Tan
authors.affiliation: New Jersey Department of Health, Office of the State Epidemiologist/Environmental and Occupational Health Services, Communicable Disease Service, Trenton, NJ.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: McHugh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009515:New Jersey / Q000453:epidemiology; D010865:Pilot Projects; D011008:Pneumococcal Infections / Q000145:classification* / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D062486:Public Health Surveillance / Q000379:methods*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*; D055815:Young Adult