title: ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
abstract: Parkinson's Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 genes have been linked to familial forms of PD. Two of these genes encode for ATP13A2 and alpha-synuclein (asyn), proteins that seem to be members of a common network in both physiological and disease conditions. Thus, two different hypotheses have emerged supporting a role of ATP13A2 and asyn in metal homeostasis or in autophagy. Interestingly, an appealing theory might combine these two cellular pathways. Here we review the novel findings in the interaction between these two proteins and debate the exciting roads still ahead.
authors.affiliation: Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, 37073 Göttingen, Germany. ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal.
authors.forename: Tomás
authors.initials: T
authors.lastname: Lopes da Fonseca
authors.affiliation: Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, 37073 Göttingen, Germany. ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal.
authors.forename: Tiago Fleming
authors.initials: TF
authors.lastname: Outeiro
keywords: ATP13A2; Parkinson's Disease; alpha-synuclein; autophagy; metal homeostasis