title: Polygenic expression of teratozoospermia and normal fertility in B10.MOL-TEN1 mouse strain.
abstract: Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL-TEN1 mice, which shows high-frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B10.MOL-TEN1. Segregation analysis showed that the abnormal sperm phenotype in B10.MOL-TEN1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility.
authors.affiliation: Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan; Graduate School of Science and Engineering, Yamagata University, Yamagata, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Hirawatari
authors.forename: Naoto
authors.initials: N
authors.lastname: Hanzawa
authors.forename: Maki
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Aoyama
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Wakana
authors.forename: Hideo
authors.initials: H
authors.lastname: Gotoh
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005298:Fertility / Q000235:genetics*; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D020412:Multifactorial Inheritance; D010641:Phenotype; D013076:Sperm Count; D013077:Sperm Head / Q000473:pathology; D013094:Spermatozoa / Q000378:metabolism* / Q000473:pathology*; D013737:Testis / Q000378:metabolism
keywords: genetics; male fertility; reproduction