title: Ethnical variations in the incidence of congenital heart defects in gorgan, northern iran: a single-center study.
abstract: Background : Congenital heart disease (CHD) is the most common congenital anomaly in newborns. This study was performed to determine the live birth incidence of CHD by ethnicity and sex in Gorgan, Northern Iran.
  
  
  METHODS
  In this longitudinal, hospital-based study, 18162 live births in Dezyani Hospital in Gorgan, North of Iran, were screened for CHD, from 2007 through 2009. Clinical examination, echocardiography, color Doppler, and cardio catheterization were used as diagnostic tools. Sex, ethnicity, and type of CHD for each case were recorded in a pre-designed questionnaire. Results : The incidence rates of CHD in the native Fars, Sistani, and Turkmen subjects were 5.73 (95%CI: 4.53-7.15), 12.27 (95%CI: 8.74-16.73), and 15.93 (95%CI: 10.00-24.02) per 1000 live births, respectively. The Turkmen to native Fars and Sistani to native Fars relative risk for congenital CHD malformations was 2.77 (95%CI: 1.73-4.44; p value < 0.001) and 1.29 (95%CI: 0.77-2.18; p value < 0.323), respectively. While atrial septal defect was the most common lesion in the native Fars subjects (2.14 per 1000 [95%CI: 1.42-3.06]) and in the Sistani subjects (2.84 per 1000 [95%CI: 1.29-5.36]), in the Turkmen subjects, ventricular septal defect (4.36 per 1000 [95%CI: 1.59-9.43]), followed by atrial septal defect, was the most frequent lesion. Conclusion : This study showed that the incidence and pattern of CHD among live births in Gorgan, North of Iran, varied according to ethnicity. The risk of CHD was higher in the Turkmen and Sistani groups than in the Fars population.
authors.affiliation: Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Nikyar
authors.affiliation: Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Sedehi
authors.affiliation: Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran . ; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran .
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.affiliation: Cranfield University, London, England.
authors.forename: Arash
authors.initials: A
authors.lastname: Nikyar
authors.affiliation: Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Golalipour
keywords: Heart defect; atrial • Heart septal defect; congenital • Heart septal defect; ventricular • Ethnic group • Incidence