title: [Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas].
abstract: Membrane type 1 matrix metalloproteinase (MT1MMP) is one of matrix metalloproteinases (MMP), which play а key role in tumor invasion and metastasis. The aim of this study was to elucidate the peculiarities of expression of MT1MMP and endogenous regulators of its activity: the activator - furin and the inhibitor - TIMP-2, as invasive factors of squamous cell cervical carcinomas (SCC). The study was carried out using 11 specimens of SCC and 11 specimens of morphologically normal tissue adjacent to the tumor. It was shown that the increase of MT1-MMP and furin expression and low of TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC. Moreover, substantial expression of MT1-MMP was registered in the specimens of morphologically normal adjoining to tumor tissue. This expression was found to make an additional contribution to the destructive potential of the cervical tumor.
authors.affiliation: Orekhovich Institute of Biomedical Chemistry.
authors.forename: O S
authors.initials: OS
authors.lastname: Timoshenko
authors.affiliation: Orekhovich Institute of Biomedical Chemistry.
authors.forename: T A
authors.initials: TA
authors.lastname: Gureeva
authors.affiliation: Orekhovich Institute of Biomedical Chemistry.
authors.forename: E V
authors.initials: EV
authors.lastname: Kugaevskaia
authors.affiliation: Orekhovich Institute of Biomedical Chemistry.
authors.forename: N I
authors.initials: NI
authors.lastname: Solov'eva
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D005260:Female; D045683:Furin / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D015398:Signal Transduction; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000235:genetics* / Q000378:metabolism; D059016:Tumor Microenvironment / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: C560823:TIMP2 protein, human; D019716:Tissue Inhibitor of Metalloproteinase-2; C468731:FURIN protein, human; D045683:Furin; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14
keywords: MMP activator - furin; cervical squamous cell carcinoma; membrane type 1 matrix metalloproteinase (MT1MMP); tissue inhibitor of MMPs - TIMP-2