title: Neuropharmacological effects of methanolic extracts of Rubusfruticosus L.
abstract: OBJECTIVE
  To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities.
  
  
  METHODS
  The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming test, while line crossing in a special box was used for assessment of locomotor activity.
  
  
  RESULTS
  All extracts were found to be anxiolytic in nature, while no muscle relaxing activity or sedative effect was observed. The order of central nervous system (CNS) depressant effect for various parts of R.fruticosus was fruit > root > leaves > stem.
  
  
  CONCLUSIONS
  Our results indicate that methanolic extract of various parts of R. fruticosus possess anxiolytic and CNS depressant effects but do not possess significant sedative or muscle relaxing potential.
authors.affiliation: Department of Pharmacology, University of Karachi, Pakistan. pharmariaz@gmail.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-Ul-Haq
authors.forename: Najm
authors.initials: N
authors.lastname: Ur-Rahman
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmadi
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027824:Rosaceae / Q000737:chemistry*; D013550:Swimming
chemical_list: D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; D010936:Plant Extracts