title: Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus.
abstract: Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM.
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Nahyun
authors.initials: N
authors.lastname: Kim
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
authors.forename: Kyu-Won
authors.initials: KW
authors.lastname: Cho
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea; Natural Products Research Institute, Gyeonggi Institute of Science and Technology Promotion, Suwon 443-270, Republic of Korea.
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hong
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 362-763, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: tchun@korea.ac.kr.
authors.forename: Taehoon
authors.initials: T
authors.lastname: Chun
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: dongholee@korea.ac.kr.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D002478:Cells, Cultured; D036905:Dictamnus / Q000737:chemistry* / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D007166:Immunosuppressive Agents; D014315:Triterpenes
keywords: Antiproliferative effect; Dictamnus dasycarpus; Glabretal-type triterpenoid; Rutaceae