title: Circulating levels of TNF-like cytokine 1A correlate with reflected waves and atherosclerosis extent and may predict cardiac death in patients with stable coronary artery disease.
abstract: BACKGROUND
  TNF-like cytokine 1A (TL1A)-mediated interactions are involved in atheromatic plaque formation. In stable coronary artery disease (CAD) we examined whether circulating TL1A levels correlate with coronary and/or peripheral atherosclerosis extent and predict future cardiovascular events.
  
  
  METHODS
  In this cross-sectional study, peripheral vascular studies and TL1A serum measurements were performed in 122 consecutive patients with angiographically confirmed CAD who were followed for a median of 41.9 months. TL1A levels were compared against controls (n = 63) and 20 patients with acute coronary syndrome (ACS).
  
  
  RESULTS
  TL1A was higher in ACS than the 2 other groups (p < 0.001). In stable CAD, after adjustment for traditional risk factors independent positive correlations between TL1A serum levels and reflected waves (p = 0.049), and carotid atheromatic plaque score (p = 0.049) were evident. In stable patients with a history of ACS, TL1A levels correlated with worse endothelial function (p = 0.006), extent of CAD assessed by Gensini score (p = 0.042), and cardiac mortality (p = 0.051).
  
  
  CONCLUSIONS
  This pilot study suggests that serum TL1A measurements are of clinical value in CAD. Studies on the pathogenetic role of TL1A in atherosclerosis and its sequelae are warranted.
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece. Electronic address: stamatelopoulosk@yahoo.gr.
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Georgiou
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kanakakis
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Papamichael
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Oikonomidis
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Aimilia
authors.initials: A
authors.lastname: Mantzou
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Samouilidou
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Savvas
authors.initials: S
authors.lastname: Loizos
authors.affiliation: Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.affiliation: First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece.
authors.forename: Petros P
authors.initials: PP
authors.lastname: Sfikakis
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000503:physiopathology; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D002339:Carotid Arteries / Q000473:pathology; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000097:blood*
chemical_list: C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15
keywords: Arteriosclerosis; Atherosclerosis; CAD; TNF-like cytokine 1A