title: Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements.
abstract: A 7 month infant presented with fever and breathlessness with raised total counts. Examination revealed 90 % blasts with prominent nucleoli. Flow cytometry revealed a tight cluster in the monocytic region. The blasts showed homogenous bright CD 33/4/64/HLA D with heterogeneous expression of CD14/15/11c. Blasts were negative for CD13/MPO/Cytoplasmic CD3/19/7/34/117/5/22/TdT/CD 61/41. FISH revealed MLL gene rearrangements in the blasts. No evidence of Down's syndrome on cytogenetic studies was noted. Diagnosis of Infantile acute monoblastic leukemia was made. These leukemias are rare in infants and are associated with a poor outcome.
authors.affiliation: Oncquest Laboratories Pvt. Ltd, 3, Factory Road, New Delhi, 110029 India ; A 803, Plot 7A, Navrattan Apartments, Sector 23, Dwarka, New Delhi, 110077 India.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Sachdev
authors.affiliation: Oncquest Laboratories Pvt. Ltd, 3, Factory Road, New Delhi, 110029 India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: Oncquest Laboratories Pvt. Ltd, 3, Factory Road, New Delhi, 110029 India.
authors.forename: Mohd Ateek
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Oncquest Laboratories Pvt. Ltd, 3, Factory Road, New Delhi, 110029 India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
keywords: Acute leukemia; Infantile; MLL; Monoblastic