title: Enantioselective gold catalyzed dearomative [2+2]-cycloaddition between indoles and allenamides.
abstract: The highly enantioselective synthesis of densely functionalized 2,3-indoline-cyclobutanes by means of chiral gold catalysis is presented. Intermolecular formal [2+2]-cycloaddition reactions between substituted indoles and allenamides enabled direct access to methylenecyclobutane-fused indolines, featuring two consecutive quaternary stereogenic centers with excellent stereochemical control (dr > 20 : 1, ee up to 99%).
authors.affiliation: Department of Chemistry "G. Ciamician" Alma Mater Studiorum-University of Bologna via Selmi 2, 40126, Bologna, Italy. marco.bandini@unibo.it.
authors.forename: Minqiang
authors.initials: M
authors.lastname: Jia
authors.forename: Magda
authors.initials: M
authors.lastname: Monari
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Yang
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000577:Amides; D007211:Indoles; D006046:Gold