title: [¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.
abstract: BACKGROUND
  Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting.
  
  
  OBJECTIVE
  A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma.
  
  
  METHODS
  The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas.
  
  
  RESULTS
  In vivo imaging showed that the uptake of [(123)I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [(131)I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy.
  
  
  CONCLUSIONS
  Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Viallard
authors.affiliation: Clermont Université, Université Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Perrot
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Zied
authors.initials: Z
authors.lastname: Boudhraa
authors.affiliation: Centre Jean Perrin, Clermont-Ferrand, F-63011, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Jouberton
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Miot-Noirault
authors.affiliation: U1071 INSERM Université d'Auvergne, M2iSH Clermont-Ferrand, F-63000, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Bonnet
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Besse
authors.affiliation: Centre Jean Perrin, Clermont-Ferrand, F-63011, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Mishellany
authors.affiliation: Centre Jean Perrin, Clermont-Ferrand, F-63011, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Cayre
authors.affiliation: Clermont Université, Université Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Lydia
authors.initials: L
authors.lastname: Maigne
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Latifa
authors.initials: L
authors.lastname: Rbah-Vidal
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Michel
authors.initials: M
authors.lastname: D'Incan
authors.affiliation: Centre Jean Perrin, Clermont-Ferrand, F-63011, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Cachin
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chezal
authors.affiliation: Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, Inserm, U 990, F-63000 Clermont-Ferrand, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Degoul
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008543:Melanins / Q000378:metabolism; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental; D011810:Quinoxalines; D011829:Radiation Dosage; D012878:Skin Neoplasms; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D000096142:Cutaneous Malignant Melanoma
chemical_list: D007457:Iodine Radioisotopes; D008543:Melanins; C530303:N-(2-diethylaminoethyl)-6-iodoquinoxaline-2-carboxamide; D011810:Quinoxalines
keywords: dosimetry; imaging; melanin; melanoma; radiotracer; targeted radionuclide therapy