title: MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis.
abstract: Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany. Electronic address: thbaum@gmx.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baum
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Dimitrios C
authors.initials: DC
authors.lastname: Karampinos
authors.affiliation: Klinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802 München, Germany.
authors.forename: Knut
authors.initials: K
authors.lastname: Brockow
authors.affiliation: Frauenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Vanadin
authors.initials: V
authors.lastname: Seifert-Klauss
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Pia M
authors.initials: PM
authors.lastname: Jungmann
authors.affiliation: Klinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802 München, Germany.
authors.forename: Tilo
authors.initials: T
authors.lastname: Biedermann
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Rummeny
authors.affiliation: Abteilung für Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Bauer
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany; Institut und Poliklinik für Diagnostische Radiologie, Universitätsklinikum Köln, Kerpener Str. 62, 50937 Köln, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Müller
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D034721:Mastocytosis, Systemic / Q000473:pathology*; D008875:Middle Aged; D010024:Osteoporosis; D011884:Radius / Q000473:pathology; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Indolent systemic mastocytosis; Magnetic resonance imaging; Osteoporosis; Trabecular bone microstructure