title: Label free detection of nucleic acids by modulating nanochannel surfaces.
abstract: We develop surface-modified 100 nm silica nanofluidic channels that change in measured conductivity upon exposure to single- or double-stranded DNA. Through careful monitoring of both electromigrative and advective current in the channel, we can detect nanomolar concentrations of DNA. These results can be exploited for inexpensive, all-electronic DNA sensors.
authors.affiliation: Engineering Science Building, Department of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. sumita@engineering.ucsb.edu.
authors.forename: Pete
authors.initials: P
authors.lastname: Crisalli
authors.forename: Christopher
authors.initials: C
authors.lastname: McCallum
authors.forename: Sumita
authors.initials: S
authors.lastname: Pennathur
mesh_terms: D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004277:DNA, Single-Stranded; D012822:Silicon Dioxide; D004247:DNA