title: Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum.
abstract: Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K(+) concentrations (25 and 60 mM, respectively). OS shifted the concentration-response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.
authors.affiliation: a Department of Pharmacy , Federal University of Sergipe , Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe , Brazil.
authors.forename: Sylvia D F
authors.initials: SD
authors.lastname: Souza
authors.affiliation: a Department of Pharmacy , Federal University of Sergipe , Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe , Brazil.
authors.forename: Carolina S L
authors.initials: CS
authors.lastname: Franca
authors.affiliation: b Department of Chemistry , Federal University of Sergipe , Sergipe , Brazil.
authors.forename: Edenilson S
authors.initials: ES
authors.lastname: Niculau
authors.affiliation: c Agriculture Department, Federal University of Lavras, Campus Universitário , Lavras , Minas Gerais , Brazil.
authors.forename: Larissa C B
authors.initials: LC
authors.lastname: Costa
authors.affiliation: c Agriculture Department, Federal University of Lavras, Campus Universitário , Lavras , Minas Gerais , Brazil.
authors.forename: José E B
authors.initials: JE
authors.lastname: Pinto
authors.affiliation: b Department of Chemistry , Federal University of Sergipe , Sergipe , Brazil.
authors.forename: Péricles B
authors.initials: PB
authors.lastname: Alves
authors.affiliation: a Department of Pharmacy , Federal University of Sergipe , Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe , Brazil.
authors.forename: Rosilene M
authors.initials: RM
authors.lastname: Marçal
mesh_terms: D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D031339:Ocimum / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000494:pharmacology*
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D009822:Oils, Volatile; D010276:Parasympatholytics; D010938:Plant Oils; C007633:estragole
keywords: Ocimum selloi; methyl chavicol; spasmolytic