title: Sushi Domain-Containing Protein 3: A Potential Target for Breast Cancer.
abstract: Aromatase inhibitors (AIs) are the most effective endocrine treatment for estrogen receptor α-positive (ERα+) postmenopausal breast cancer. Identification of biomarkers that are able to predict AIs responsiveness of patients is a key for successful treatment. The currently used biomarkers for tamoxifen responsiveness, which including ERα as well as progesterone receptor can only predict part of the potential responders to AIs treatment. Sushi domain-containing protein 3 (SUSD3) is a potential novel biomarker of AIs responsiveness. The lack of SUSD3 expression in breast cancer tissue can be an important predictor for non-responsiveness to AI. Here we reviewed the property and function of SUSD3, its usage as a biomarker and the practicability for SUSD3 to become a target for immune therapy. We suggest this protein can be potentially measured or targeted for prevention, diagnostic, and therapeutic purposes for estrogen or progesterone-dependent disorders including breast cancer in women.
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School of Medicine, Nanjing University, Nanjing, Jiangsu, China.
authors.forename: Enze
authors.initials: E
authors.lastname: Jiang
authors.affiliation: Department of Medical Oncology, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Medicine, Nanjing University, Nanjing, Jiangsu, China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA.
authors.forename: Anna Junjie
authors.initials: AJ
authors.lastname: Shangguan
authors.affiliation: Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China. lijiemd@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D014408:Biomarkers, Tumor; D007155:Immunologic Factors; D008565:Membrane Proteins; C000597072:SUSD3 protein, human
keywords: Aromatase inhibitors; Breast cancer; Sushi domain-containing protein 3