title: A barcode-free combinatorial screening platform for matrix metalloproteinase screening.
abstract: Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.
authors.affiliation: Department of Biomedical Engineering and ‡Department of Mechanical Engineering, Johns Hopkins University , Baltimore, Maryland 21218, United States.
authors.forename: Tushar D
authors.initials: TD
authors.lastname: Rane
authors.forename: Helena C
authors.initials: HC
authors.lastname: Zec
authors.forename: Tza-Huei
authors.initials: TH
authors.lastname: Wang
mesh_terms: D057075:Enzyme Assays / Q000295:instrumentation*; D004867:Equipment Design; D020782:Matrix Metalloproteinases / Q000032:analysis / Q000378:metabolism*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*
chemical_list: D020782:Matrix Metalloproteinases