title: Metal complex of the first-generation quinolone antimicrobial drug nalidixic acid: structure and its biological evaluation.
abstract: A novel binuclear squire planar complex of nalidixic acid with Ag(I) metal ion with the formula [Ag(Nal)2] has been synthesized. The synthesized metal complex was characterized using CHN analysis, Fourier-transformed infra-red (FT-IR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), ultra violet-visible (Uv-vis) and single-crystal X-ray diffraction (XRD). The newly synthesized complex shows more advanced antifungal activity compared to the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi, 110007, India.
authors.forename: Anamika
authors.initials: A
authors.lastname: Debnath
authors.forename: Navin Kumar
authors.initials: NK
authors.lastname: Mogha
authors.forename: Dhanraj T
authors.initials: DT
authors.lastname: Masram
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008670:Metals / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000737:chemistry* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D008670:Metals; D015363:Quinolones; D009268:Nalidixic Acid