title: The effect of epidermal growth factor applied locally for pelviureteral anastomoses.
abstract: OBJECTIVE
  To investigate the effect of epidermal growth factor (EGF) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA).
  
  
  METHODS
  Twelve rabbits were divided equally into 2 groups: control (C) and epidermal growth factor (EGF). A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were administered locally with 100 μg/kg EGF (EGF group) all around the anastomosis lines after the surgical procedure. The C group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later.
  
  
  RESULTS
  There were no significant differences in the GTA, N, or R scores in the C group compared with those in the EGF group. In the EGF group, AI and CI scores were lower than they were in the C group. CD, GTFM, and PTR in the EGF group were higher than they were in the C group.
  
  
  CONCLUSIONS
  EGF did not decrease CD, GTFM, or PTR, but did decrease important parameters in wound healing such as acute inflammation and chronic inflammation in an experimental model of PUA in rabbits.
authors.affiliation: Necmettin Erbakan University Turkey.
authors.forename: Müslim
authors.initials: M
authors.lastname: Yurtçu
authors.affiliation: Yakın Doğu University Turkey.
authors.forename: Zeliha Füsun
authors.initials: ZF
authors.lastname: Baba
keywords: Epidermal growth factor; acute inflammation; chronic inflammation; pelviureteral anastomoses