title: Long-term Effects of Plant Stanols on the Lipid Profile of Patients With Hypercholesterolemia. A Randomized Clinical Trial.
abstract: OBJECTIVE
  Plant stanol consumption may improve long-term cholesterol control. The aim of the present study was to evaluate the effectiveness of 2g/day of plant stanols in reducing low-density lipoprotein cholesterol levels in patients with hypercholesterolemia.
  
  
  METHODS
  This randomized, double-blind, and placebo-controlled study included 182 adults diagnosed with hypercholesterolemia. A yogurt drink containing 2g of plant stanols was administered to 91 participants in the intervention group; 91 participants in the control group received unsupplemented yogurt. The primary end point was the change in the lipid profile at 12 months.
  
  
  RESULTS
  Low-density lipoprotein cholesterol levels at 12 months were significantly more reduced in the stanol intervention group than in the control group: 13.7 (95% confidence interval, 3.2-24.1) mg/dL (P=.011). A reduction of more than 10% in low-density lipoprotein cholesterol was achieved by a significantly higher proportion of participants in the intervention group (relative risk=1.7; 95% confidence interval, 1.1-2.7). In this group, the mean (standard deviation) level of low-density lipoprotein cholesterol decreased by 11.0% (23.9%).
  
  
  CONCLUSIONS
  Our results confirm that administration of plant stanols at a dosage of 2 g/day for 12 months significantly reduces (by slightly more than 10%) the concentrations of low-density lipoprotein cholesterol in individuals with hypercholesterolemia. Trial registration (www.ClinicalTrials.gov): Current Controlled Trials NCT01406106.
authors.affiliation: Centro de Salud de La Roda, Servicio de Salud de Castilla-La Mancha, La Roda, Albacete, Spain. Electronic address: iparraga@sescam.jccm.es.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Párraga-Martínez
authors.affiliation: Centro de Salud Zona IV, Servicio de Salud de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain.
authors.forename: Jesús D
authors.initials: JD
authors.lastname: López-Torres-Hidalgo
authors.affiliation: Centro de Salud de Almansa, Servicio de Salud de Castilla-La Mancha, Albacete, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Del Campo-Del Campo
authors.affiliation: Centro de Salud de La Roda, Servicio de Salud de Castilla-La Mancha, La Roda, Albacete, Spain.
authors.forename: María P
authors.initials: MP
authors.lastname: Galdón-Blesa
authors.affiliation: Centro de Salud de La Roda, Servicio de Salud de Castilla-La Mancha, La Roda, Albacete, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Precioso-Yáñez
authors.affiliation: Gerencia Atención Integrada de Albacete, Servicio de Salud de Castilla-La Mancha, Albacete, Spain.
authors.forename: Joseba
authors.initials: J
authors.lastname: Rabanales-Sotos
authors.affiliation: Centro de Salud Zona III, Servicio de Salud de Castilla-La Mancha, Albacete, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: García-Reyes-Ramos
authors.affiliation: Unidad de Apoyo a la Investigación Clínica, Gerencia de Atención Integrada de Albacete, Servicio de Salud de Castilla-La Mancha, Albacete, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Andrés-Pretel
authors.affiliation: Unidad de Apoyo a la Investigación Clínica, Gerencia de Atención Integrada de Albacete, Servicio de Salud de Castilla-La Mancha, Albacete, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Navarro-Bravo
authors.affiliation: Departamento de Farmacia, Gerencia de Atención Integrada de Albacete, Albacete, Spain.
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Lloret-Callejo
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008383:Margarine; D008875:Middle Aged; D012855:Sitosterols / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D015014:Yogurt
chemical_list: D008055:Lipids; D012855:Sitosterols; C407042:plant stanol ester; D008383:Margarine
keywords: Atención primaria de salud; Clinical trial; Ensayo clínico; Fitosteroles; Hipercolesterolemia; Hypercholesterolemia; Phytosterols; Primary health care