title: Quinolinyl-thienyl chalcones as monoamine oxidase inhibitors and their in silico modeling studies.
abstract: Mitochondrial enzymes monoamine oxidases were thought to be an emerging and useful therapeutic target for neurodegenerative disorders. Monoamine oxidases have two isoforms, A and B. MAO-A is related with metabolism of amine neurotransmitters in the brain whereas MAO-B is concerned with aging related neurodegenerative disorders. Therefore the identification, characterization and discovery of potent MAO-A and B inhibitors is very crucial in research. A series of quinolyl-thienyl chalcones were tested against MAO-A and B. Among the screened compounds, most of them revealed potent MAO-A and B inhibition. Compound 5i presented most potent MAO-A inhibition having IC50 values 0.047 µM, while 4l showed excellent inhibitory potency against MAO-B among all the tested compound having IC50 values 0.063 µM. Molecular modelling studies were performed against human MAO-A and MAO-B for the explanation of binding site interactions.
authors.forename: Sumera
authors.initials: S
authors.lastname: Zaib
authors.forename: Syed Umar Farooq
authors.initials: SU
authors.lastname: Rizvi
authors.forename: Sana
authors.initials: S
authors.lastname: Aslam
authors.forename: Matloob
authors.initials: M
authors.lastname: Ahmad
authors.forename: Syed Mobasher
authors.initials: SM
authors.lastname: Ali Abid
authors.forename: Mariya
authors.initials: M
authors.lastname: Al-Rashida
authors.affiliation: Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.. drjamshed@ciit.net.pk.
authors.forename: Jamshed
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D047188:Chalcones; D008996:Monoamine Oxidase Inhibitors; C000607214:quinolinyl-thienyl chalcone; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human