title: Movement disorders in 2014. Genetic advances spark a revolution in dystonia phenotyping.
abstract: Genetic revelations in 2014 are testing traditional classification systems for movement disorders, and our approach to clinical diagnostics. Mutations in dystonia-associated genes lead to a spectrum of disorders with different phenotypes, underscoring the need for stringent clinical phenotyping of patients with movement disorders, as well as next-generation sequencing approaches.
authors.affiliation: University of Groningen, University Medical Center Groningen, Departments of Genetics and Neurology, PO Box 30.001, 9700 RB Groningen, Netherlands.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: de Koning
authors.affiliation: University of Groningen, University Medical Center Groningen, Departments of Genetics and Neurology, PO Box 30.001, 9700 RB Groningen, Netherlands.
authors.forename: Marina A J
authors.initials: MA
authors.lastname: Tijssen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004421:Dystonia / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques; D006801:Humans; D051379:Mice; D009069:Movement Disorders / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D009154:Mutation