title: Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population.
abstract: OBJECTIVE
  To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects.
  
  
  METHODS
  There were 404 healthy subjects included prospectively in this study. The subjects were divided into 3 groups (Group 1:93 subjects aged < 18, Group 2:189 subjects aged between 18 and 59, and Group 3:122 subjects aged ≥ 60). Corneal compensated IOP (IOPCC), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer.
  
  
  RESULTS
  When all the study groups were evaluated, a moderately significant negative correlation was found between age and CH and between age and CRF (Spearman's rho = -0.372 and -0.353, respectively; P < 0.0001 for both correlations). There were significant age-related differences among the 3 groups in terms of IOPg, CH, CRF, and central corneal thickness (P = 0.002, P = 0.000, P = 0.000, P = 0.006). There was no confirmation of any difference of IOPcc among the groups (P = 0.427).
  
  
  CONCLUSIONS
  The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.
authors.affiliation: Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Sen
authors.forename: Kadriye Ufuk
authors.initials: KU
authors.lastname: Elgin
authors.forename: Pinar
authors.initials: P
authors.lastname: Yüksekkaya
authors.forename: Mehmet Hakan
authors.initials: MH
authors.lastname: Tirhiş
authors.forename: Fatma Nur Baran
authors.initials: FN
authors.lastname: Aksakal
authors.forename: Mehmet Yasin
authors.initials: MY
authors.lastname: Teke
authors.forename: Faruk
authors.initials: F
authors.lastname: Oztürk
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003315:Cornea / Q000502:physiology*; D004548:Elasticity / Q000502:physiology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D014421:Turkey; D055815:Young Adult