title: [Solid pseudopapillary tumors of the pancreas: clinical and morphological characteristics, specific features of their immunophenotype, and diagnostic problems].
abstract: OBJECTIVE
  To analyze 60 cases of solid pseudopapillary tumors (SPTs) of the pancreas, to reveal their most characteristic clinical and morphological features, and to study their possible histogenesis.
  
  
  METHODS
  Sixty cases of SPTs of the pancreas underwent clinical, morphological, and immunohistochemical (IHC) examinations; a comparison group consisted of 86 pancreatic tumors of other histogenesis.
  
  
  RESULTS
  It has been shown for the first time that SPTs are characterized by the nuclear expression of claudin 3 and the cytoplasmic expression of claudin 7. It has been also ascertained that the aberrant perinuclear (dot-like) expression of CD99 is a unique feature of these tumors.
  
  
  CONCLUSIONS
  SPTs of the pancreas are distinguished by a diversity of clinical manifestations and morphological features, but have a unique immunophenotype, which can differentiate them from other types of pancreatic tumors.
authors.forename: L E
authors.initials: LE
authors.lastname: Gurevich
authors.forename: I A
authors.initials: IA
authors.lastname: Kazantseva
authors.forename: I N
authors.initials: IN
authors.lastname: Sokolova
authors.forename: N A
authors.initials: NA
authors.lastname: Korsakova
authors.forename: E I
authors.initials: EI
authors.lastname: Kuzovleva
authors.forename: O A
authors.initials: OA
authors.lastname: Chistiakova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Aver'ianova
authors.forename: A V
authors.initials: AV
authors.lastname: Egorov
authors.forename: T A
authors.initials: TA
authors.lastname: Britvin
authors.forename: A A
authors.initials: AA
authors.lastname: Dolzhikov
authors.forename: V I
authors.initials: VI
authors.lastname: Egorov
mesh_terms: D000071443:12E7 Antigen; D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D002648:Child; D062465:Claudin-3 / Q000096:biosynthesis; D057167:Claudins / Q000096:biosynthesis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D057089:Pathology, Molecular
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; C568122:CLDN3 protein, human; C473255:CLDN7 protein, human; D015815:Cell Adhesion Molecules; D062465:Claudin-3; D057167:Claudins