title: Bayesian Multiscale Modeling of Closed Curves in Point Clouds.
abstract: Modeling object boundaries based on image or point cloud data is frequently necessary in medical and scientific applications ranging from detecting tumor contours for targeted radiation therapy, to the classification of organisms based on their structural information. In low-contrast images or sparse and noisy point clouds, there is often insufficient data to recover local segments of the boundary in isolation. Thus, it becomes critical to model the entire boundary in the form of a closed curve. To achieve this, we develop a Bayesian hierarchical model that expresses highly diverse 2D objects in the form of closed curves. The model is based on a novel multiscale deformation process. By relating multiple objects through a hierarchical formulation, we can successfully recover missing boundaries by borrowing structural information from similar objects at the appropriate scale. Furthermore, the model's latent parameters help interpret the population, indicating dimensions of significant structural variability and also specifying a 'central curve' that summarizes the collection. Theoretical properties of our prior are studied in specific cases and efficient Markov chain Monte Carlo methods are developed, evaluated through simulation examples and applied to panorex teeth images for modeling teeth contours and also to a brain tumor contour detection problem.
authors.affiliation: Department of Statistics, Stanford University, Department of Statistics, Florida State University, Department of Statistical Science, Duke University.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Gu
authors.affiliation: Department of Statistics, Stanford University, Department of Statistics, Florida State University, Department of Statistical Science, Duke University.
authors.forename: Debdeep
authors.initials: D
authors.lastname: Pati
authors.affiliation: Department of Statistics, Stanford University, Department of Statistics, Florida State University, Department of Statistical Science, Duke University.
authors.forename: David B
authors.initials: DB
authors.lastname: Dunson
keywords: Biomedical imaging; closed curves; cyclic basis; deformation; functional data; hierarchical modeling; multiscale