title: The polymorphism of hypoxia-inducible factor-1a gene in endometrial cancer.
abstract: BACKGROUND
  Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer.
  
  
  METHODS
  75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing.
  
  
  RESULTS
  For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk.
  
  
  CONCLUSIONS
  Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.
authors.affiliation: Women's Reproductive Health Research Center, Department of Medical Genetics, Tabriz University of Medical Sciences, Tabriz, Iran E-mail : dastranjt@gmailcom,akbarzadehab@tbzmedacir.
authors.forename: Leila
authors.initials: L
authors.lastname: Kafshdooz
authors.forename: Ali Dastranj
authors.initials: AD
authors.lastname: Tabrizi
authors.forename: Seyyed Mojtaba
authors.initials: SM
authors.lastname: Mohaddes
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Kafshdooz
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Jalal
authors.initials: J
authors.lastname: Gharesouran
mesh_terms: D018269:Carcinoma, Endometrioid / Q000235:genetics*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit