title: A role for AT1 receptor-associated proteins in blood pressure regulation.
abstract: The renin angiotensin-system is one of the most important humoral regulators of blood pressure. The recently discovered angiotensin receptor-associated proteins serve as local modulators of the renin angiotensin-system. These proteins interact with the AT1 receptor in a tissue-specific manner and regulate the sensitivity of the target cell for angiotensin II. The predominant effect of the AT1 receptor-associated proteins on angiotensin II-induced signaling is the modulation of the surface expression of the AT1 receptor. This review provides an overview of our current knowledge with respect to the relevance of AT1 receptor-associated proteins for blood pressure regulation. Two aspects of blood pressure regulation will be discussed in detail: angiotensin II-dependent volume homoeostasis and vascular resistance.
authors.affiliation: Institute of Physiology, University of Regensburg, Germany. Electronic address: hayo@castrop.com.
authors.forename: Hayo
authors.initials: H
authors.lastname: Castrop
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology
chemical_list: C449676:AGTRAP protein, human; D048868:Adaptor Proteins, Signal Transducing; D044140:Receptor, Angiotensin, Type 1