title: The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns.
abstract: OBJECTIVE
  Both the ischemia-reperfusion injury and the abnormal changes of redox status are the important pathologic changes in the burn shock stage for severe burns. The study of clinical dynamic, quantitative relevance about them was performed.
  
  
  METHODS
  In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury.
  
  
  RESULTS
  The results revealed that the duration of abnormal fluctuation of redox status in the early stage of severe burns was longer than that of the traditional clinical shock stage (2-3 days). The changes of overreduction soon after injury were closely related to the hypovolemia-related hypoxia, and the following overoxidation status was consistent with the pathophysiological changes related to the reperfusion, and the degrees of variation were closely related to the severity of burn injury and prognosis. Moreover, early surgery (3 days after injury) had no significant influence on the changing trend of abnormal redox status in the early stage of severe burns.
  
  
  CONCLUSIONS
  The ischemia-reperfusion injury caused by burn shock appears the main factor contributing to the abnormal biphasic changes of redox status in the early stage of severe burns. Our findings provide useful information for the redox regulation treatment for burn shock.
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. Electronic address: zlizhu@yahoo.com.
authors.forename: Lizhu
authors.initials: L
authors.lastname: Zhi
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital of Zhejiang University School of Medicine (Binjiang Branch), Hangzhou, China.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Chaoheng
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Xuanliang
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Burn Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Chunmao
authors.initials: C
authors.lastname: Han
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D006400:Hematocrit; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012769:Shock / Q000209:etiology / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism*; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014527:Uric Acid; D019344:Lactic Acid