title: The role of dietary fat throughout the prostate cancer trajectory.
abstract: Prostate cancer is the second most common cancer diagnosed world-wide; however, patients demonstrate exceptionally high survival rates. Many lifestyle factors, including obesity and diet, are considered risk factors for advanced prostate cancer. Dietary fat is a fundamental contributor to obesity and may be specifically important for prostate cancer patients. Prostate cancer treatment can result in changes in body composition, affecting quality of life for survivors by increasing the risk of co-morbidities, like cardiovascular disease and diabetes. We aim to examine dietary fat throughout the prostate cancer treatment trajectory, including risk, cancer development and survivorship. Focusing on one specific nutrient throughout the prostate cancer trajectory provides a unique perspective of dietary fat in prostate cancer and the mechanisms that may exacerbate prostate cancer risk, progression and recurrence. Through this approach, we noted that high intake of dietary fat, especially, high intake of animal and saturated fats, may be associated with increased prostate cancer risk. In contrast, a low-fat diet, specifically low in saturated fat, may be beneficial for prostate cancer survivors by reducing tumor angiogenesis and cancer recurrence. The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key pathway moderating dietary fat intake and prostate cancer development and progression.
authors.affiliation: Department of Kinesiology, University of Waterloo, 200 University Avenue W., Waterloo, ON N2L 3G1, Canada. kmdiseba@uwaterloo.ca.
authors.forename: Katie M
authors.initials: KM
authors.lastname: Di Sebastiano
authors.affiliation: Department of Kinesiology, University of Waterloo, 200 University Avenue W., Waterloo, ON N2L 3G1, Canada. mmourtzakis@uwaterloo.ca.
authors.forename: Marina
authors.initials: M
authors.lastname: Mourtzakis
mesh_terms: D001823:Body Composition; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D011788:Quality of Life; D015398:Signal Transduction; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D013002:Somatomedins; D051057:Proto-Oncogene Proteins c-akt