title: Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?
abstract: The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemistry recognition in biotransformations usually occurs at the site of the transformation or when it is close to it (not more than 3 bonds). However, there are a growing number of enzymatic transformations which surpass the limits of stereorecognition of remote chiral (or prochiral) centers. In this account, we would like to present some aspects of biocatalyzed remote resolutions and remote desymmetrizations to call attention for these challenging transformations.
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Av. Dos Estados 5001, Bairro Bangu, CEP 09210-580 Santo André, SP, Brazil.
authors.forename: Rodrigo L O R
authors.initials: RL
authors.lastname: Cunha
authors.affiliation: Escola de Engenharia, Universidade Presbiteriana Mackenzie, Rua da Consolação, 930, CEP 01302-907 São Paulo, SP, Brazil.
authors.forename: Edgard A
authors.initials: EA
authors.lastname: Ferreira
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Av. Dos Estados 5001, Bairro Bangu, CEP 09210-580 Santo André, SP, Brazil.
authors.forename: Camila S
authors.initials: CS
authors.lastname: Oliveira
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Av. Dos Estados 5001, Bairro Bangu, CEP 09210-580 Santo André, SP, Brazil. Electronic address: alvaro.omori@ufabc.edu.br.
authors.forename: Álvaro T
authors.initials: ÁT
authors.lastname: Omori
mesh_terms: D055162:Biocatalysis; D001671:Biochemistry; D006867:Hydrolases; D007700:Kinetics; D013237:Stereoisomerism
chemical_list: D006867:Hydrolases
keywords: Desymmetrization; Hydrolases; Kinetic resolution; Remote resolution; Remote stereocontrol