title: Altered heart rate variability depend on the characteristics of coronary lesions in stable angina pectoris.
abstract: OBJECTIVE
  Dysfunction of cardiac autonomic nerve system is considered as one of risk factors for coronary atherosclerotic heart disease. Heart rate variability (HRV) has been used to study the correlation between damage of coronary artery and dysfunction of autonomic nervous system. We hypothesize the correlation between damage of coronary artery and dysfunction of autonomic nervous system by HRV among subjects with stable angina.
  
  
  METHODS
  A 236 subjects who diagnosed as stable angina pectoris by elective coronary angiography, were divided into two groups by Gensini score system (GS):GS≤32 (GS1) and GS2>32 (GS2). Subgroups were divided based on location of stenosis lesions and the number of coronary artery disease. 86 subjects suspicious with stable angina pectoris with normal coronary angiography were selected as the control group. All subjects were received 24-hour ambulatory electrocardiogram and the result of time-domain HRV was analyzed (SDNN, SDANN, SDNNind, RMSSD, PNN50).
  
  
  RESULTS
  Compared with control group, SDNN, SDNNind and RMSSD lower in GS1, and SDNN, SDANN, SDNNind, RMSSD, PNN50 lower in GS2; ccompared with GS1, SDNN was lower in GS2. Compared with control group, SDNN in one-vessel, SDNN, SDANN in two-vessel diseased and in three-vessel diseased were lower, and compared with two-vessel diseased, SDNN, SDANN lower in three-vessel diseased. Compared with right-coronary artery diseased, SDNN and SDANN in left-coronary artery diseased group were lower, while compared with lesions in left circumflex, SDNN in lesions in left anterior descending artery lower.
  
  
  CONCLUSIONS
  HRV may be play a crucial role in estimating the correlation between damage of coronary artery and dysfunction of autonomic nerve system.
authors.affiliation: Department of Cardiology, the Affiliated Hefei Hospital of Anhui Medical University (The 2nd People's Hospital of Hefei); Hefei Anhui Province-China. Fengjun0071@sina.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.forename: Ailing
authors.initials: A
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhengfei
authors.initials: Z
authors.lastname: Chen
authors.forename: Linlin
authors.initials: L
authors.lastname: Hou
authors.forename: Chunmiao
authors.initials: C
authors.lastname: Luo
authors.forename: Yongjing
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Pan
mesh_terms: D000787:Angina Pectoris / Q000503:physiopathology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001341:Autonomic Nervous System; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index