title: Brain and arterial abnormalities following prenatal X-ray irradiation in mice assessed by magnetic resonance imaging and angiography.
abstract: The present study aimed to quantitatively characterize changes in the whole brain and arterial morphology in response to prenatal ionizing irradiation. Magnetic resonance imaging (MRI) and angiography (MRA) were used to evaluate brain and arterial abnormalities in 8-week-old male mice prenatally exposed to X-ray radiation at a dose of 0.5 or 1.0 Gy on embryonic day (E) 13. Irradiated mice demonstrated decreased brain volume, increased ventricular volume, and arterial malformation. Additionally, MRA signal intensity and arterial thickness in the anterior cerebral artery, middle cerebral artery, and basilar artery were lower in radiation-exposed mice than in control mice. MRI and MRA are useful tools for assessing brain and arterial abnormalities after prenatal exposure to radiation.
authors.affiliation: Division of Health Sciences, Department of Medical Engineering, Osaka University Graduate School of Medicine; Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology.
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Saito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sawada
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D005260:Female; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D014965:X-Rays / Q000009:adverse effects*
keywords: brain abnormalities; cerebral artery malformation; magnetic resonance angiography; magnetic resonance imaging; prenatal radiation exposure