title: Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI.
abstract: The obese lipid profile is associated with increased free fatty acids and triacylglycerides. Currently, little is known about the plasma lipid species associated with obesity. In this study, we compared plasma lipid fatty acid (FA) profiles as a function of BMI. Profiling phospholipid (PL) FAs and their respective oxylipids could predict which obese individuals are more likely to suffer from diseases associated with chronic inflammation or oxidative stress. We investigated the relationship between BMI and plasma PL (PPL) FA composition in 126 men using a quantitative gas chromatography analysis. BMI was inversely associated with both PPL nervonic and linoleic acid (LA) but was positively associated with both dihomo-γ-linolenic and palmitoleic acid. Compared to lean individuals, obese participants were more likely to have ω-6 FAs, except arachidonic acid and LA, incorporated into PPLs. Obese participants were less likely to have EPA and DHA incorporated into PPLs compared to lean participants. Non-esterified plasma PUFA and oxylipid analysis showed ω-6 oxylipids were more abundant in the obese plasma pool. These ω-6 oxylipids are associated with increased angiogenesis (i.e. epoxyeicosatrienoates), reactive oxygen species (i.e. 9-hydroxyeicosatetraenoate), and inflammation resolution (i.e. Lipoxin A4). In summary, BMI is directly associated with specific PPL FA and increased ω-6 oxylipids.
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.
authors.forename: C Austin
authors.initials: CA
authors.lastname: Pickens
authors.affiliation: College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: Lorraine M
authors.initials: LM
authors.lastname: Sordillo
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Comstock
authors.affiliation: Sanford School of Medicine, The University of South Dakota, Sioux Falls, SD, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: Harris
authors.affiliation: College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: Kari
authors.initials: K
authors.lastname: Hortos
authors.affiliation: College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA; Tri-County Gastroenterology Professional Corporation, Clinton Tri-County Gastroenterology Professional Corporation, MI, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Kovan
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA. Electronic address: imigjeni@msu.edu.
authors.forename: Jenifer I
authors.initials: JI
authors.lastname: Fenton
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood / Q000737:chemistry; D000368:Aged; D015992:Body Mass Index; D002849:Chromatography, Gas / Q000379:methods; D005229:Fatty Acids, Monounsaturated / Q000097:blood / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000032:analysis* / Q000097:blood; D006801:Humans; D019787:Linoleic Acid / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D014280:Triglycerides / Q000032:analysis* / Q000097:blood
chemical_list: D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C008757:palmitoleic acid; C013147:nervonic acid; D019787:Linoleic Acid; D015126:8,11,14-Eicosatrienoic Acid
keywords: Biomarker; Human; Inflammation; Lipidome; Nervonic acid; Obesity