title: Serum Preptin and Amylin Values in Psoriasis Vulgaris and Behçet's Patients.
abstract: BACKGROUND
  Insulin resistance is found in both psoriasis and Behçet's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Behçet's disease.
  
  
  OBJECTIVE
  We aimed to explore how the amounts of preptin and amylin change in psoriasis and Behçet's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls.
  
  
  METHODS
  The study registered 30 patients with psoriasis, 30 patients with Behçet's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptide, insulin, and serum preptin and amylin levels were measured in all subjects.
  
  
  RESULTS
  Serum preptin and amylin levels were significantly lower in the patients with psoriasis and Behçet's disease than in the control group (P < 0.001, P = 0.004, and P = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Behçet's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly lower in the psoriasis patient group relative to the control group (P = 0.02 and P = 0.03, respectively), while the values for the Behçet's disease group did not differ significantly from those for the control group
  
  
  CONCLUSIONS
  Serum levels of preptin and amylin were significantly lower in patients with psoriasis and Behçet's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases.
authors.affiliation: Department of Dermatology, Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
authors.forename: Fatma Baskaya
authors.initials: FB
authors.lastname: Dogan
authors.affiliation: Faculty of Medicine, Department of Dermatology, Firat University, Elazig, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Cicek
authors.affiliation: Faculty of Medicine, Department of Biochemistry, Firat University, Elazig, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Faculty of Medicine, Department of Dermatology, Firat University, Elazig, Turkey.
authors.forename: Selma Bakar
authors.initials: SB
authors.lastname: Dertlioglu
authors.affiliation: Faculty of Medicine, Department of Biostatistics, Firat University, Elazig, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Halisdemir
authors.affiliation: Faculty of Medicine, Department of Dermatology, Dicle University, Diyarbakır, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Ucak
authors.affiliation: Faculty of Medicine, Department of Dermatology, Firat University, Elazig, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Demir
authors.affiliation: Department of Dermatology, Elazig Education and Research Hospital, Elazig, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Erden
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D007335:Insulin-Like Growth Factor II; D058228:Islet Amyloid Polypeptide / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011565:Psoriasis / Q000097:blood*
chemical_list: D058228:Islet Amyloid Polypeptide; D010446:Peptide Fragments; C443100:preptin; D007335:Insulin-Like Growth Factor II
keywords: Behçet's disease; amylin; insulin resistance; preptin; psoriasis