title: Prognostic value of plasma pentraxin-3 levels in patients with stable coronary artery disease after drug-eluting stent implantation.
abstract: Pentraxin-3 (PTX3) is an inflammatory marker thought to be more specific to cardiovascular inflammation than C-reactive protein (CRP). Our aim was to assess the prognostic value of PTX3 in patients with stable coronary artery disease (CAD) after drug eluting stent (DES) implantation. Plasma PTX3 levels were measured before percutaneous coronary intervention (PCI) and at 24 h post-PCI in 596 consecutive patients with stable CAD. Patients were followed up for a median of 3 years (range 1-5) for major adverse cardiovascular events (MACEs). We found that the post-PCI plasma PTX3 levels were significantly higher at 24 h after PCI than pre-PCI, patients with MACEs had higher post-PCI PTX3 levels compared with MACEs-free patients, patients with higher post-PCI PTX3 levels (median > 4.384 ng/mL) had a higher risk for MACEs than those with PTX3 < 4.384 ng/mL, and post-PCI PTX3, cTnI, multiple stents, and age but not high-sensitivity CRP (hsCRP) were independently associated with the prevalence of MACEs after DES implantation. The present study shows that post-PCI PTX3 may be a more reliable inflammatory predictor of long-term MACEs in patients with stable CAD undergoing DES implantation than CRP. Measurement of post-PCI PTX3 levels could provide a rationale for risk stratification of patients with stable CAD after DES implantation.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Haibo
authors.affiliation: Clinical Laboratory Center, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Xiaofang
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Chunming
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Jie
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Guozhong
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Limei
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Cao
authors.initials: C
authors.lastname: Yong
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Bao
authors.initials: B
authors.lastname: Yingchun
authors.affiliation: Clinical Laboratory Center, Yinzhou People's Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wangjun
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Junbo
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017239:Paclitaxel / Q000008:administration & dosage; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D017239:Paclitaxel; D000683:Serum Amyloid P-Component; D020123:Sirolimus; D000099153:Pentraxins; C489443:zotarolimus