title: [Clinical features and risk factors analysis of acute graft-versus-host disease in patients with related HLA-haploidentical non T cell-depleted in vitro peripheral hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To study the clinical features of acute graft-versus-host disease (aGVHD) and its risk factors for the related HLA-haploidentical non T cell-depleted in vitro peripheral hematopoietic stem cell transplantation (RHNT-PBSCT).
  
  
  METHODS
  From July 2002 to December 2012, 104 patients who underwent the RHNT-PBSCT were enrolled to analyze the incidences, location and its risk factors of aGVHD, compared with those of the 103 patients who received the HLA-matched sibling non T cell-depleted in vitro PBSCT (MSNT-PBSCT) in the same period.
  
  
  RESULTS
  (1)The cumulative incidence of aGVHD in the RHNT-PBSCT group was significantly higher than the MSNT-PBSCT group [(56.2±4.7)% vs (34±3.6)%, P<0.05], but the cumulative incidences of II-IV and III-IVgrade aGVHD had no significant difference between the two groups[(39.5±2.9)% vs (21.2±5.4)%, P>0.05; (12.6±4.1)% vs (10.8±2.4)%, P>0.05]. (2)The cumulative incidence of cutaneous aGVHD was significantly higher in RHNT-PBSCT group than that in MSNT-PBSCT group [(42.3±3.2)% vs (17.5±2.3)%, P<0.05]. The cumulative incidences of liver and gastrointestinal aGVHD between the two groups had no significant difference [(7.7±2.1)% vs (12.6±3.4)%, P>0.05; (16.3±4.5)% vs (10.3±2.5)%, P>0.05]. (3)The 3-year disease free survival (DFS) and overall survival(OS) of RHNT-PBSCT group and MSNT-PBSCT group were (63±5.5)%, (65.2±4.7)% and (74.2±5.4)%, (77.4±5)% respectively, without significance (P=0.078, P=0.052). (4)aGVHD occurrence with HLA haplotype (P=0.003) and matched loci (P=0.002) were significantly correlated by univariate analysis. Multivariate analysis showed that only the HLA typing is a risk factor for aGVHD (HR=1.891, P=0.03).
  
  
  CONCLUSIONS
  Although the incidence of total aGVHD in RHNT-PBSCT protocol is higher than that in MSNT-PBSCT, but there was no significance in severe aGVHD and cutaneous aGVHD was the common type, which indicates that RHNT-PBSCT protocol is feasible.
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Xue
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Tian
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Xianlin
authors.initials: X
authors.lastname: Duan
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qu
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Xu
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Bingzhao
authors.initials: B
authors.lastname: Wen
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Yichun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Xinyou
authors.initials: X
authors.lastname: Wang
authors.affiliation: Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University; Xinjiang Uygur Autonomous Region Research Institute of Hematology;Urumqi 830054, China.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Cao
mesh_terms: D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D036102:Peripheral Blood Stem Cell Transplantation; D012307:Risk Factors; D035781:Siblings; D013601:T-Lymphocytes