title: Megalocytic interstitial nephritis following acute pyelonephritis with Escherichia coli bacteremia: a case report.
abstract: Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.
authors.affiliation: Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hee Jin
authors.identifier: 0000-0002-8953-3254
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kwai Han
authors.identifier: 0000-0002-3049-9055
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: In Young
authors.identifier: 0000-0001-8846-4448
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Seulkee
authors.identifier: 0000-0002-5551-4178
authors.initials: S
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hye Ryoun
authors.initials: HR
authors.lastname: Jang
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Ghee Young
authors.initials: GY
authors.lastname: Kwon
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D002439:Cefotaxime / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011704:Pyelonephritis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006435:Renal Dialysis; D012772:Shock, Septic / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D003404:Creatinine; D002439:Cefotaxime; D008775:Methylprednisolone
keywords: Acute Kidney Injury; Interstitial Nephritis; Megalocytic Interstitial Nephritis