title: BRAF mutation as a potential marker to identify the proximal colon serrated polyps with malignant potential.
abstract: A large number of serrated polyps with malignant potential in the proximal colon were underestimated using currently available criteria mostly based on architectural and cytological features, contributing to proximal interval colorectal cancers. Recently, increasing evidences indicate that BRAF((V600E)) mutation is a specific molecular feature and driver of the serrated pathway, and proximal serrated polyps with BRAF((V600E)) mutation have a high risk of progression to malignancy. We proposed that immunohistochemical detection of BRAF((V600E)) using a BRAF((V600E)) mutation-specific antibody is a feasible technique for reproducibly identifying proximal serrated polyps with malignant potential in clinical practice, which may need more aggressive treatment and vigilant clinical monitoring.
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College Luzhou 646000, Sichuan, China.
authors.forename: Xiangsheng
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College Luzhou 646000, Sichuan, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D003106:Colon / Q000473:pathology; D003111:Colonic Polyps / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF(V600E) mutation; colorectal cancer; microvesicular hyperplasitc polyps; sessile serrated polyps