title: Comparison of serum triglyceride levels with propofol in long chain triglyceride and propofol in medium and long chain triglyceride after short term anesthesia in pediatric patients.
abstract: BACKGROUND
  Significant increase in serum triglyceride (ST) concentration have been described in adult population after prolonged administration of propofol formulation containing long chain triglyceride (LCT). Though, medium chain triglyceride-LCT (MCT-LCT) propofol when compared with LCT propofol for long-term sedation in adults resulted in identical triglyceride levels, the elimination of triglyceride was faster in patients administered MCT-LCT propofol.
  
  
  METHODS
  A total of 40 children were randomized into two groups of 20 each; Group I were induced with 1% LCT propofol (3 mg/kg) and Group II with 1% medium and LCT propofol and maintained with descalating dose of 20.15 and 10 mg/kg/h at 10 min intervals. Blood samples for ST concentration were obtained before induction of anesthesia, at the end of propofol infusion and 4 h after terminating propofol infusion.
  
  
  RESULTS
  ST levels were raised significantly above the basal values in both the groups but the rise was significantly higher in Group I (P < 0.05). Four hours after stopping propofol infusion the triglyceride levels were similar to the basal values in Group II, whereas in Group I the values were significantly greater than the baseline (P < 0.05) as well as those of Group II (P < 0.05). No clinically significant adverse effect of hypertriglyceridemia was observed.
  
  
  CONCLUSIONS
  Even short term anesthesia with LCT and MCT-LCT propofol (1%) leads to elevated ST levels. The increase in ST levels is less with MCT-LCT propofol and elimination of triglyceride is also rapid after terminating MCT-LCT propofol infusion.
authors.affiliation: Department of Anesthesia and Intensive Care, Post graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Ishwar
authors.initials: I
authors.lastname: Bhukal
authors.affiliation: Department of Anesthesia and Intensive Care, Post graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Gokul
authors.initials: G
authors.lastname: Thimmarayan
authors.affiliation: Department of Anesthesia and Intensive Care, Post graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Indu
authors.initials: I
authors.lastname: Bala
authors.affiliation: Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Mumbai, India.
authors.forename: Sohan Lal
authors.initials: SL
authors.lastname: Solanki
authors.affiliation: Department of Anesthesia and Intensive Care, Post graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Tanvir
authors.initials: T
authors.lastname: Samra
keywords: Long chain triglyceride propofol; medium chain triglyceride-long chain triglyceride propofol; pediatric; serum triglyceride