title: New and Cytotoxic Components from Antrodia camphorata.
abstract: The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1) and 4,4'-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2) together with 2,3,6-trimethoxy-4-methylphenol (3), 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol (4), citreoanthrasteroid B (5) and dankasterones A (6) and B (7) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 4-7 showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50 values ranging from 6.7 to 15.3 µM and from 12.5 to 23.1 µM, respectively.
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. thlee1@ntu.edu.tw.
authors.forename: Tzong-Huei
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Department of Nursing, Hungkuang University, Taichung 443, Taiwan. ccchen@sunrise.hk.edu.tw.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan. liaohf@seed.net.tw.
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Liao
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hschang@kmu.edu.tw.
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. biomei@tmue.edu.tw.
authors.forename: Mei-Hwei
authors.initials: MH
authors.lastname: Tseng
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. taiwanfir@dragon.nchu.edu.tw.
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. hhko@kmu.edu.tw.
authors.forename: Horng-Huey
authors.initials: HH
authors.lastname: Ko
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. kuoyh@mail.cmu.edu.tw.
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055491:Antrodia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D051379:Mice; D019311:Staurosporine / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D019311:Staurosporine