title: Adipose tissue content and distribution in children and adolescents with bronchial asthma.
abstract: BACKGROUND
  The excess of adipose tissue and the pattern of adipose tissue distribution in the body seem to play an important role in the complicated dependencies between obesity and risk of developing asthma. The aim of the present study was to determine nutritional status in children and adolescents with bronchial asthma with special emphasis on adipose tissue distribution evaluated on the basis of skin-fold thicknesses, and to determine the relationships between patterns of adipose tissue distribution and the course of the disease.
  
  
  METHODS
  Anthropometric data on height, weight, circumferences and skin-fold thicknesses were extracted from the medical histories of 261 children diagnosed with asthma bronchitis. Values for children with asthma were compared to Polish national growth reference charts. Distribution of subcutaneous adipose tissue was evaluated using principal components analysis (PCA). Multivariate linear regression analyses tested the effect of three factors on subcutaneous adipose tissue distribution: type of asthma, the severity of the disease and the duration of the disease.
  
  
  RESULTS
  Mean body height in the children examined in this study was lower than in their healthy peers. Mean BMI and skin-fold thicknesses were significantly higher and lean body mass was lower in the study group. Excess body fat was noted, especially in girls. Adipose tissue was preferentially deposited in the trunk in girls with severe asthma, as well as in those who had been suffering from asthma for a longer time. The type of asthma, atopic or non-atopic, had no observable effect on subcutaneous adipose tissue distribution in children examined.
  
  
  CONCLUSIONS
  The data suggest that long-treated subjects and those with severe bronchial asthma accumulate more adipose tissue on the trunk. It is important to regularly monitor nutritional status in children with asthma, especially in those receiving high doses of systemic or inhaled glucocorticosteroids, and long-term treatment as well.
authors.affiliation: Department of Human Biology, University of Wrocław, ul. Kuźnicza 35, 50-138 Wrocław, Poland. Electronic address: wilota@antropo.uni.wroc.pl.
authors.forename: Wioleta
authors.initials: W
authors.lastname: Umławska
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000293:Adolescent; D001249:Asthma / Q000150:complications*; D001823:Body Composition / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008297:Male; D009752:Nutritional Status; D012307:Risk Factors; D012885:Skinfold Thickness; D014797:Vital Capacity / Q000502:physiology
keywords: Bronchial asthma; Children; Fat distribution; Skin-fold thicknesses; Spirometry