title: Wound healing and skin regeneration.
abstract: The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University, School of Medicine, New York, New York 10016 Department of Cell Biology, New York University, School of Medicine, New York, New York 10016.
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeo
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University, School of Medicine, New York, New York 10016 Department of Cell Biology, New York University, School of Medicine, New York, New York 10016.
authors.forename: Wendy
authors.initials: W
authors.lastname: Lee
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University, School of Medicine, New York, New York 10016 Department of Cell Biology, New York University, School of Medicine, New York, New York 10016.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ito
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000503:physiopathology; D004847:Epithelial Cells / Q000502:physiology; D018859:Hair Follicle / Q000254:growth & development; D006801:Humans; D008322:Mammals; D051379:Mice; D023421:Models, Animal; D062326:Re-Epithelialization / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012879:Skin Physiological Phenomena; D013234:Stem Cells / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*