title: Treatment of High-Risk T-NHL with Stem Cell Transplantation: A Single Center Experience.
abstract: Prognosis of peripheral and other advanced T cell lymphomas is poor. 20 patients with a median age of 46.4 (range 20.5-64.1) years were treated with autoSCT (n = 6) or alloSCT (n = 14) from 1996 to 2013. All patients were at high risk either due to the IPI-score or to the fact that SCT was part of a salvage therapy. Conditioning prior to alloSCT was myeloablative in seven cases (50 %). The patients were pretreated with 8.5 (median, range 2-38) cycles of chemotherapy. Ten patients are alive in CR after a median follow-up of 1.3 years (range 0.1-13.3). OS was 53 % after one and 40 % after 10 years. Best survival was reached after related alloSCT (80 % at 10 years) compared to other modalities. GvHD did not influence survival. AlloSCT from related donors can cure patients from T-cell lymphomas. Unrelated alloSCT or high-dose therapy and autoSCT are an option for patients without a familiar donor.
authors.affiliation: Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Busemann
authors.affiliation: Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Klein
authors.affiliation: Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: Christian Andreas
authors.initials: CA
authors.lastname: Schmidt
authors.affiliation: Institute for Pathology, Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Evert
authors.affiliation: Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: Gottfried
authors.initials: G
authors.lastname: Dölken
authors.affiliation: Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
authors.forename: William H
authors.initials: WH
authors.lastname: Krüger
keywords: Allogeneic stem cell transplantation; Autologous stem cell transplantation; Graft versus lymphoma effects; T-cell derived non-Hodgkin’s lymphoma