title: Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation.
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Arantza
authors.initials: A
authors.lastname: Onaindia
authors.affiliation: Group of Research in Lymphomas (Medical Oncology Department), Oncohematology Area, Instituto Investigación Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors.forename: Sagrario
authors.initials: S
authors.lastname: Gómez
authors.affiliation: Hematology Department, Hospital U. Puerta de Hierro-Majadahonda, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Piris-Villaespesa
authors.affiliation: Pathology Department, Hospital U. Gregorio Marañón, Madrid, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Martínez-Laperche
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Cereceda
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Montes-Moreno
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Batlle
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Sonia González
authors.initials: SG
authors.lastname: de Villambrosia
authors.affiliation: Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain Cancer Epidemiology Research Group, Oncohematology Area, Instituto Investigación Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Pollán
authors.affiliation: Group of Research in Molecular Pathology of Cancer (Pathology Department), Oncohematology Area, Instituto Investigación Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Martín-Acosta
authors.affiliation: Group of Research in Lymphomas (Medical Oncology Department), Oncohematology Area, Instituto Investigación Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: González-Rincón
authors.affiliation: Pathology Department, Hospital U. Gregorio Marañón, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Menarguez
authors.affiliation: Pathology Department, Hospital U. La Paz, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Alvés
authors.affiliation: Pathology Department, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: Socorro M
authors.initials: SM
authors.lastname: Rodriguez-Pinilla
authors.affiliation: Pathology Department, MD Anderson Cancer Center, Madrid, Spain.
authors.forename: Juan F
authors.initials: JF
authors.lastname: García
authors.affiliation: Pathology Department, Hospital Virgen de la Salud, Toledo, Spain.
authors.forename: Manuela
authors.initials: M
authors.lastname: Mollejo
authors.affiliation: Pathology Department, Hospital U. Santiago de Compostela, La Coruña, Spain.
authors.forename: Máximo
authors.initials: M
authors.lastname: Fraga
authors.affiliation: Hematology Department, Hospital U. Puerta de Hierro-Majadahonda, Madrid, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: García-Marco
authors.affiliation: Pathology Department, Hospital U. Marqués de Valdecilla-Santander, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Piris
authors.affiliation: Group of Research in Lymphomas (Medical Oncology Department), Oncohematology Area, Instituto Investigación Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain msbeato@idiphim.org.
authors.forename: Margarita
authors.initials: M
authors.lastname: Sánchez-Beato
mesh_terms: D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology*; D009154:Mutation; D059645:Mutation Rate; D010750:Phosphoproteins / Q000235:genetics; D011379:Prognosis; D000072260:RNA Splicing Factors; D051881:Receptor, Notch1 / Q000235:genetics* / Q000378:metabolism; D017413:Ribonucleoprotein, U2 Small Nuclear / Q000235:genetics; D015533:Transcriptional Activation
chemical_list: D010750:Phosphoproteins; D000072260:RNA Splicing Factors; D051881:Receptor, Notch1; D017413:Ribonucleoprotein, U2 Small Nuclear; C112491:SF3B1 protein, human
keywords: NOTCH1 activation; chronic lymphocytic leukemia