title: Concentrated parenteral nutrition solutions and central venous catheter complications in preterm infants.
abstract: Standardised, concentrated neonatal parenteral nutrition (PN) regimens can overcome early nutritional deficits in very preterm infants. A PN regimen with increased macronutrient content (standardised, concentrated, added macronutrients parenteral (SCAMP)) has been shown to improve early head growth in a randomised controlled trial. Line complications including late onset sepsis were secondary outcomes of this study. Infants were started on standardised, concentrated PN at birth and randomised at 2-5 days to either switch to SCAMP or remain on control PN. Central venous catheter (CVC), blood culture (BC) and inflammatory marker data were collected for the 28-day intervention period. 150 infants were randomised with mean (SD) birth weight (g) of 900 (158) versus 884 (183) in SCAMP (n=74) and control (n=76) groups, respectively. There were no differences in CVC use/type or duration or in positive/negative BC with/without associated C reactive protein rise in SCAMP versus control groups. Increasing the macronutrient content of a standardised, concentrated neonatal PN regimen does not increase CVC complication rates.
  
  
  BACKGROUND
  ISRCTN 76597892.
authors.affiliation: Department of Neonatology, Liverpool Women's Hospital, Liverpool, UK.
authors.forename: T
authors.initials: T
authors.lastname: Whitby
authors.affiliation: Department of Neonatology, Liverpool Women's Hospital, Liverpool, UK.
authors.forename: P
authors.initials: P
authors.lastname: McGowan
authors.affiliation: Department of Neonatology, Liverpool Women's Hospital, Liverpool, UK Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Turner
authors.affiliation: Department of Neonatology, Liverpool Women's Hospital, Liverpool, UK.
authors.forename: C
authors.initials: C
authors.lastname: Morgan
mesh_terms: D017668:Age of Onset; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D062905:Central Venous Catheters / Q000009:adverse effects*; D006801:Humans; D062071:Infant, Extremely Premature / Q000254:growth & development*; D007231:Infant, Newborn; D057947:Parenteral Nutrition Solutions / Q000008:administration & dosage*; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D057947:Parenteral Nutrition Solutions; D002097:C-Reactive Protein