title: Novel polyacetylenes from Coreopsis tinctoria Nutt.
abstract: Phytochemical investigation of the 95% EtOH extract of Coreopsis tinctoria Nutt. resulted in the isolation of two novel polyacetylenes, (2S)-(3Z,11E)-decadiene-5,7,9-triyne-1,2-diol (1) and (2R)-(3E,11Z)-decadiene-5,7,9-triyne-1,2-diol (2), together with two known polyacetylenes (3 and 4). The structures of these novel compounds were determined by extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. Compounds 1, 2, and 4 were evaluated for their anti-proliferative activities against C26 cell growth and inhibitory effects on the lipo-poly-saccharides-induced nitric oxide production using murine macrophage RAW 264.7 cells. However, compounds 1, 2, and 4 just showed weak activities.
authors.affiliation: a Laboratory of Ethnopharmacology , Institute of Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital/West China Medical School, Sichuan University , Chengdu 610041 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.forename: Guang
authors.initials: G
authors.lastname: Xin
authors.forename: Bao-Zhan
authors.initials: BZ
authors.lastname: Huang
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
mesh_terms: D000818:Animals; D031945:Coreopsis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; C000602168:decadiene-5,7,9-triyne-1,2-diol; D053279:Polyynes; D009569:Nitric Oxide
keywords: Coreopsis tinctoria; anti-inflammation; anti-proliferation; polyacetylene; structure elucidation