title: A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors.
abstract: A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600036, India.
authors.forename: Indrapal S
authors.initials: IS
authors.lastname: Aidhen
authors.forename: Ramesh
authors.initials: R
authors.lastname: Mukkamala
authors.forename: Christopher
authors.initials: C
authors.lastname: Weidner
authors.forename: Sascha
authors.initials: S
authors.lastname: Sauer
mesh_terms: D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D047492:Peroxisome Proliferator-Activated Receptors / Q000737:chemistry* / Q000378:metabolism; D012459:Salicylates / Q000138:chemical synthesis* / Q000737:chemistry; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C549543:3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid; D007004:Hypoglycemic Agents; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors; D012459:Salicylates; D013267:Stilbenes; C000597294:amorfrutin A