title: [Species structure and staphylococci bioprofile characteristics--ausative agents of perinatal infectious-inflammation pathology in children of Orenburg].
abstract: OBJECTIVE
  Analysis of taxonomic structure and bioprofile of staphylcocci--causative agents of cutaneous and ophthalmic forms of perinatal infectious-inflammation pathology (IIP) in Orenburg neonates.
  
  
  METHODS
  Bacteriologic study in 308 neonates with clinical signs of cutaneous and ophthalmic forms of perinatal IIP was carried out with isolation of microorganisms from lesions and their species (genus) identification by generally accepted methods. The presence of hemolytic, anti-lysozyme, activity, ability to form biofilms, resistance to antimicrobial cationic peptides of human leukocytes (intercid) and thrombocytes (trombodefensins), sensitivity to antibiotics were determined in the isolated staphylococci strains.
  
  
  RESULTS
  Staphylococci dominated in the structure of causative agents of cutaneous and ophthalmic forms of perinatal IIP (76.2%) and among those coagulase-negative staphylococci had a priority position (82.4 ± 3.4%). Staphylococci had a distinctive pathogenic potential and frequently had antibiotic resistance.
  
  
  CONCLUSIONS
  Perinatal IIP is examined as a variant of endogenous bacterial infection. The necessity of microbiologic monitoring for development of effective approaches to therapy and prophylaxis of perinatal IIP is justified.
authors.forename: V A
authors.initials: VA
authors.lastname: Gritsenko
authors.forename: T V
authors.initials: TV
authors.lastname: Biriukova
authors.forename: A A
authors.initials: AA
authors.lastname: Vialkova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Ivanov
mesh_terms: D018441:Biofilms / Q000254:growth & development; D004352:Drug Resistance, Microbial / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D013203:Staphylococcal Infections / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity