title: [Clinical analyses of hepatocellular carcinoma and nasopharyngeal multiple primary cancers].
abstract: OBJECTIVE
  To explore the clinicopathological characteristics, diagnosis, treatment outcomes and survival of hepatocellular carcinoma (HCC) and nasopharyngeal multiple primary cancers.
  
  
  METHODS
  The clinical data of 12 male patients with hepatocellular and nasopharyngeal multiple primary cancers were retrospectively analyzed.
  
  
  RESULTS
  Second primary cancer was diagnosed with a median age of 54.5 years. Hepatitis B surface antigen (HBsAg) was detected in 7 patients (58.3%) and 6 cases (50.0%) had a family history of cancer. The treatments included radiochemotherapy (n = 5), radiotherapy (n = 6) and non-therapy (n = 1). And the interventions included hepatic surgery (n = 6), interventional treatment (n = 4) and conservative (n = 2). The 1, 3 and 5-year overall survival rates were 90.9%, 81.8% and 58.4% and the HCC-specific survival rates 80.0% at 1 year and 57.1% at 3 years respectively. The HCC-specific survival rates of surgery group were significantly better than those of the non-surgical group. The 1, 3-year HCC-specific survival rates were 100.0%, and 100.0%vs 50.0% and 0 respectively (P = 0.002).
  
  
  CONCLUSIONS
  HCC and nasopharyngeal multiple primary cancers are not rare and careful follow-ups are necessary . The co-existence of HCC and nasopharyngeal multiple primary cancers does not imply a worse prognosis. And radical resection of HCC is considered.
authors.affiliation: Second Department of General Surgery, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Li
authors.affiliation: Email: liyijie@mail.sysu.edu.cn.
authors.forename: Qing'an
authors.initials: Q
authors.lastname: Zeng
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D006528:Carcinoma, Hepatocellular; D006514:Hepatitis B Surface Antigens; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms; D009378:Neoplasms, Multiple Primary; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D006514:Hepatitis B Surface Antigens