title: Androgen receptor-positive mucoepidermoid carcinoma: case report and literature review.
abstract: Androgen receptor (AR) is usually expressed in salivary duct carcinoma (SDC), but only infrequently in other carcinoma types including mucoepidermoid carcinoma (MEC). The clinicopathological characteristics of AR-positive MEC remain to be clarified. Here we report a case of AR-positive MEC. A 76-year-old man presented with a growing painless tumor of the right parotid. The resected tumor was a high-grade tumor with necroses. Since the tumor was positive for AR, GCDFP-15, and HER2, SDC was first suspected, but it was also positive for CK5/6 and P63, and negative for S-100 protein and α-smooth muscle actin. In addition, scattered mucous secreting tumor cells were found in the tumor nests, and they were positive for Alcian blue. A diagnosis of AR-positive MEC was finally made. The patient died of the tumor 5 years after the surgery. The present case may expand the histopathological spectrum of high-grade MEC.
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ishibashi
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Fujii
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Masaki
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Beppu
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawakita
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ijichi
authors.affiliation: Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shimozato
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan hinagaki@med.nagoya-cu.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology*; D011944:Receptors, Androgen / Q000096:biosynthesis*
chemical_list: C410798:AR protein, human; D014408:Biomarkers, Tumor; D011944:Receptors, Androgen
keywords: GCDFP-15; HER2; androgen receptor; mucoepidermoid carcinoma; salivary duct carcinoma