title: Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection.
abstract: OBJECTIVE
  Acute aortic dissection is a life-threatening cardiovascular emergency. Neutrophil-to-lymphocyte ratio is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. The aim of the present study was to evaluate the relationship between admission neutrophil-to-lymphocyte ratio and in-hospital mortality in acute type I aortic dissection.
  
  
  METHODS
  We retrospectively evaluated 123 consecutive patients who had undergone emergent surgery for acute type I aortic dissection. Patients were divided into 2 groups as patients dying in the hospital (Group 1) and those discharged alive (Group 2). All parameters, including neutrophil-to-lymphocyte ratio, were compared between the 2 groups and predictors of mortality was estimated by using multivariate analysis.
  
  
  RESULTS
  A total of 104 patients (79 males, mean age: 55.2 + 14 years) were included in the final analysis. In multivariate analyses, cross- clamp time, cardiopulmonary bypass time, intensive care-unit duration, platelet count, and neutrophil-to-lymphocyte ratio were found to be independent predictors of mortality. Patients with higher neutrophil-to-lymphocyte ratios had a significantly higher mortality rate (hazard ratio: 1.05; 95% CI: 1.01-1.10; P = 0.033). Receiver operating characteristic analysis revealed that using a cut-off point of 8, neutrophil-to-lymphocyte ratio predicts mortality with a sensitivity of 70% and specificity of 53%.
  
  
  CONCLUSIONS
  This study suggests that admission neutrophil-to-lymphocyte ratio is a potential predictive parameter for determining the in-hospital mortality of acute type I aortic dissection.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Lafçi
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Ciçek
authors.forename: Haci Alper
authors.initials: HA
authors.lastname: Uzun
authors.forename: Adnan
authors.initials: A
authors.lastname: Yalçinkaya
authors.forename: Adem İlkay
authors.initials: Aİ
authors.lastname: Diken
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.forename: Kumral
authors.initials: K
authors.lastname: Çağli
authors.forename: İrfan
authors.initials: İ
authors.lastname: Taşoğlu
authors.forename: Hikmet Selçuk
authors.initials: HS
authors.lastname: Gedik
authors.forename: Kemal
authors.initials: K
authors.lastname: Korkmaz
authors.forename: Orhan Eren
authors.initials: OE
authors.lastname: Günertem
authors.forename: Kerim
authors.initials: K
authors.lastname: Çağali
mesh_terms: D000784:Aortic Dissection / Q000401:mortality* / Q000601:surgery; D001014:Aortic Aneurysm / Q000401:mortality* / Q000601:surgery; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000166:cytology*; D061646:Operative Time; D010976:Platelet Count; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers