title: Reducing occupational stress with a B-vitamin focussed intervention: a randomized clinical trial: study protocol.
abstract: BACKGROUND
  Workplace stress in Australia and other western countries has been steadily increasing over the past decade. It can be observed not only in terms of increased compensation claims but also costs due to absenteeism, loss of productivity at work and reduced psychological and physiological health and well-being. Given the cost and pervasive effects of stress in the modern workforce, time efficient and cost-effective interventions capable of reducing occupational stress (or strain) and burnout are urgently required for the improved well-being of stressed employees. One intervention gaining scientific traction is supplementation with nutritional interventions, particularly the B group vitamins.
  
  
  METHODS
  This study was developed to examine the effects of B group vitamins on workplace stress and mood variables with a sample of full-time employed older adults who subjectively report feeling stressed. The study is a randomized, double-blind, placebo-controlled, parallel-groups clinical trial where 200 (N = 100/group) participants will be randomized to receive Blackmores® Executive B Stress Formula or placebo daily for a period of 6 months. Participants will be tested at baseline and 6 months post-randomization on workplace stress, cognitive, personality and mood measures, cardiovascular (brachial and aortic systolic and diastolic blood pressures as well as arterial stiffness), biochemical (assays to measure inflammation and safety) as well as genetic assessments (to assess stress processing) and neuroimaging measures (to investigate in vivo mechanisms of action of B vitamins). In addition to this pre- and post- supplementation testing, participants will also complete a battery of self-report questionnaires online to assess their stress and mood once a month for the duration of the study. The primary aim of the study is to investigate the effects of B vitamin supplementation on work related stress. The secondary aims are to explore the mechanisms underpinning any changes in mood or workplace stress due to the B vitamin intervention by examining relationships between cognitive, biological, neuroimaging and cardiovascular variables over 6 months. A subset of 40 participants (N = 20/group) will undergo neuroimaging at baseline and at 6 months using functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) in order to further explore in vivo mechanisms of action of B vitamins.
  
  
  BACKGROUND
  Australia and New Zealand Clinical Trials Register (ANZCTR):ACTRN12613000294752.
authors.affiliation: Centre for Human Psychopharmacology, Swinburne University, PO Box 218, HawthornVictoria, Melbourne, Australia. cstough@swin.edu.au.
authors.forename: Con
authors.initials: C
authors.lastname: Stough
authors.forename: Tamara
authors.initials: T
authors.lastname: Simpson
authors.forename: Justine
authors.initials: J
authors.lastname: Lomas
authors.forename: Grace
authors.initials: G
authors.lastname: McPhee
authors.forename: Clare
authors.initials: C
authors.lastname: Billings
authors.forename: Stephen
authors.initials: S
authors.lastname: Myers
authors.forename: Chris
authors.initials: C
authors.lastname: Oliver
authors.forename: Luke A
authors.initials: LA
authors.lastname: Downey
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D001315:Australia; D003071:Cognition; D003362:Cost-Benefit Analysis; D004032:Diet; D019587:Dietary Supplements / Q000191:economics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000523:psychology*; D010919:Placebos; D013315:Stress, Psychological / Q000188:drug therapy* / Q000517:prevention & control; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage*
chemical_list: D010919:Placebos; D014803:Vitamin B Complex