title: [Medical therapies for locally advanced/metastatic kidney cancer].
abstract: OBJECTIVE
  To analyze the medical literature concerning the results of the international randomized muticentric trials concerning therapeutic innovations, mainly targeted therapies in locally advanced and or metastatic renal cell cancer and to evaluate the benefit of these TT.
  
  
  METHODS
  We performed a review of publications that concerned this topic published from 2000 to 2014.
  
  
  RESULTS
  They concerned the large randomized trials have showed a benefit of the targeted therapies in the treatment of clear cell carcinomas in terms of progression-free survival.
  
  
  CONCLUSIONS
  Advances in molecular biology have allowed the development of these targeted therapies that have all proved their role in the treatment of metastatic renal cell carcinoma.
authors.affiliation: Hôpital Abderrahmane Mami, service d'oncologie médicale, 1005 Tunis, Tunisie. Electronic address: mehdiafrit23@yahoo.fr.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Afrit
authors.affiliation: Hôpital Abderrahmane Mami, service d'oncologie médicale, 1005 Tunis, Tunisie.
authors.forename: Yosra
authors.initials: Y
authors.lastname: Yahyaoui
authors.affiliation: Hôpital Charles Nicolle, service d'urologie, 1005 Tunis, Tunisie.
authors.forename: Aderrazek
authors.initials: A
authors.lastname: Bouzouita
authors.affiliation: Université Tunis El Manar, hôpital Abderahmane Mami, service de radiologie, 1005 Tunis, Tunisie.
authors.forename: Saoussen
authors.initials: S
authors.lastname: Hantous
authors.affiliation: Hôpital Abderrahmane Mami, service d'oncologie médicale, 1005 Tunis, Tunisie.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Labidi
authors.affiliation: Hôpital Charles Nicolle, service d'urologie, 1005 Tunis, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chebil
authors.affiliation: Université Tunis El Manar, hôpital Abderahmane Mami, service de radiologie, 1005 Tunis, Tunisie; Institut Gustave-Roussy, département de médecine, 94805 Villejuif, France.
authors.forename: Khaoula
authors.initials: K
authors.lastname: Ben Miled
authors.affiliation: Institut Gustave-Roussy, département de médecine, 94805 Villejuif, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Escudier
authors.affiliation: Hôpital Abderrahmane Mami, service d'oncologie médicale, 1005 Tunis, Tunisie.
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D018450:Disease Progression; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D013520:Urologic Surgical Procedures