title: Maternal diet during pregnancy and unilateral retinoblastoma.
abstract: OBJECTIVE
  Previous studies have suggested a role for parental diet in childhood cancer prevention, but there are few studies of retinoblastoma. The aim of this study was to examine the relation between maternal diet and unilateral retinoblastoma.
  
  
  METHODS
  A case-control study of 163 unilateral RB cases and 136 controls ascertained information on maternal diet during pregnancy using a standardized food frequency questionnaire. Logistic regression was used to assess the relation between retinoblastoma and food groups and dietary patterns.
  
  
  RESULTS
  We observed a negative association between retinoblastoma and intake of fruit [odds ratio (OR) 0.38, 95 % confidence interval (CI) 0.14-1.02]. Positive associations were seen with intake of cured meats (OR 5.07, 95 % CI 1.63-15.70) and fried foods (OR 4.89, 95 % CI 1.72-13.89). A food pattern of high fruits and vegetables and low fried food and sweets was negatively associated with disease (OR 0.75, 95 % CI 0.61-0.92).
  
  
  CONCLUSIONS
  Our study provides preliminary evidence that mothers who consume diets higher in fruit and lower in fried foods and cured meats during pregnancy may reduce the risk of unilateral retinoblastoma in their offspring.
authors.affiliation: Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, 650 Charles E. Young Drive, Box 951772, Los Angeles, CA, 90095-1772, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Lombardi
authors.forename: Arupa
authors.initials: A
authors.lastname: Ganguly
authors.forename: Greta R
authors.initials: GR
authors.lastname: Bunin
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Azary
authors.forename: Vivian
authors.initials: V
authors.lastname: Alfonso
authors.forename: Beate
authors.initials: B
authors.lastname: Ritz
authors.forename: Julia E
authors.initials: JE
authors.lastname: Heck
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D005638:Fruit; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D008460:Meat; D009752:Nutritional Status; D016017:Odds Ratio; D011247:Pregnancy; D019572:Retinal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012175:Retinoblastoma / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014675:Vegetables