title: Survival time and molecular subtypes of breast cancer after radiotherapy in Thailand.
abstract: BACKGROUND
  Breast cancer is an important cause of death among women. One way of classifying different forms of breast cancer is by molecular features, usually in terms of the four subtypes: luminal A, luminal B, HER2-enriched, and triple negative.
  
  
  OBJECTIVE
  This study aimed to investigate the association between molecular subtypes and survival among breast cancer patients treated with radiotherapy.
  
  
  METHODS
  A retrospective cohort study was conducted. The subjects were 272 breast cancer patients who had received treatment in the radiotherapy unit at Srinagarind Hospital, Thailand, between 1 January, 1999, and 31 May, 2009. The end of the study was 1 June, 2014. Overall survival was defined as the time elapsing between initial registration at the radiotherapy unit and death or the end of the study. Survival curves were estimated by the Kaplan-Meier method, and a multivariate analysis was performed using Cox's proportional hazard regression model.
  
  
  RESULTS
  The patient mean age was 47.5±10.4 at the time of diagnosis. Of the 272 patients, 146 (53.7%) were classified as luminal A, 12 (4.4%) as luminal B, 30 (11.0%) as HER2-enriched, and 84 (30.9%) as triple negative. The overall survival rates at 1, 3 and 5 years were 87.1%, 68.4% and 59.2%, respectively. According to molecular subtypes, HER2-enriched patients had the lowest 5-year survival rate (30.0 %, 95%CI: 15.02-46.55). The median follow-up time was 8.37 years. In the Cox model analysis a higher risk of death was found for patients with HER2-enriched (HRadj=3.34, 95%CI:1.96-5.67), triple negative (HRadj=2.17, 95%CI: 1.44-3.27), and stage IIlB (HRadj=2.20, 95%CI: 1.16-4.17) cancers.
  
  
  CONCLUSIONS
  The worst survival rates were among patients classified as HER2-enriched, triple negative and at stage IIIB. Early detection and an advanced treatment modality are needed to help these patients.
authors.affiliation: Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand E-mail : supannee@kku.ac.th.
authors.forename: Apichat
authors.initials: A
authors.lastname: Kongsiang
authors.forename: Vorachai
authors.initials: V
authors.lastname: Tangvoraphonkchai
authors.forename: Chananya
authors.initials: C
authors.lastname: Jirapornkul
authors.forename: Supannee
authors.initials: S
authors.lastname: Promthet
authors.forename: Siriporn
authors.initials: S
authors.lastname: Kamsa-Ard
authors.forename: Krittika
authors.initials: K
authors.lastname: Suwanrungruang
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012189:Retrospective Studies; D013785:Thailand; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human