title: New flavonoid glycosides from Sedum aizoon L.
abstract: Five new flavonoid glucosides (3-4, 10-12) and a new phenolic derivative (5), together with eight known compounds including three flavonoid glucosides (6-8), three phenolic compounds (1-2, 9) and two megastigmane glucosides (13, 14), were isolated from the ethanol extract of the aerial part of Sedum aizoon L. Among them, compounds 9, 13 and 14 were isolated and identified from this genus for the first time. The structures of compounds were elucidated on the basis of 1D and 2D NMR (HSQC, HMBC and COSY) spectra and the HR-ESI-MS data. These compounds were tested for their antibacterial efficacies against both Gram-positive and Gram-negative bacteria. Compounds 1, 2, 3, 7 and 10 showed certain antibacterial activity; it showed more potency against Gram-positive than against Gram-negative bacteria. Compound 2 showed the most pronounced antibacterial effectiveness against Staphylococcus aureus Rosenbach with MIC value of 7.8μg·mL(-1). The in vitro anti-proliferative activities against HepG2, MCF-7 and A549 tumor cell lines were also evaluated. The result suggested compound 7 exhibited moderate cytotoxic activities with IC50 values of 46.30, 75.27 and 49.76μmol/L, respectively.
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
authors.forename: Tanye
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
authors.forename: Zhonghuan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
authors.forename: Tianli
authors.initials: T
authors.lastname: Lei
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
authors.forename: Chongning
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China. Electronic address: wangjingyk@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medicinal Plant, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China. Electronic address: jincailu@126.com.
authors.forename: Jincai
authors.initials: J
authors.lastname: Lu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry* / Q000302:isolation & purification; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D031963:Sedum / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003512:Cyclohexanones; D005419:Flavonoids; D005960:Glucosides; D045792:Norisoprenoids; D010636:Phenols; C413264:megastigmane
keywords: (3S,5R,6R,7E,9S)-megastigman-7-ene-3,5,6,9-tetrol 3-O-β-d-glucopyranoside (PubChem CID: 23757168); (3S,5R,6R,7E,9S)-megastigman-7-ene-3,5,6,9-tetrol 9-O-β-d-glucopyranoside (PubChem CID: 71694406); 1-O-sinpoyl glucopyranoside (PubChem CID: 77338752); Antibacterial activity; Cytotoxicity; Flavonoid glucoside; Gallic acid (PubChem CID: 370); Herbacetin-8-O-β-d-glucopyranoside (PubChem CID: 44259936); Methyl gallate (PubChem CID: 7428); Myricetin-3-O-β-d-glucopyranoside (PubChem CID: 44259426); Phenolic compounds; Quercetin-3-O-α-l-rhamnopyranoside (PubChem CID: 40486293); Sedum aizoon L