title: The use of thiazides in chronic kidney disease.
abstract: Hypertension is often difficult to control in patients with chronic kidney disease. Clinicians often view thiazide and thiazide-like diuretics as being ineffective in reducing blood pressure in patients with chronic kidney disease, and prefer to use loop diuretics, especially if the estimated glomerular filtration rate (eGFR) is below 50 ml/min/1.73m(2). Recent clinical trial data indicate that thiazide and thiazide-like diuretics possess important and clinically significant antihypertension properties, that are likely independent of volume reduction, even in patients with eGFR in the 15-45 ml/min range. Thiazide and thiazide-like diuretics should be given consideration for use in the treatment of hypertension in patients with chronic kidney disease, especially if there is no clinical evidence of volume overload.
authors.forename: Feras
authors.initials: F
authors.lastname: Karadsheh
authors.affiliation: Division of Nephrology, University of Maryland Medical Center, 22 S. Green St., Room N3W143, Baltimore, MD 21201, USA. mweir@medicine.umaryland.edu.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
mesh_terms: D004232:Diuretics / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D051436:Renal Insufficiency, Chronic / Q000150:complications; D049971:Thiazides / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004232:Diuretics; D049971:Thiazides