title: Mesenteric and splenic contributions to portal venous CT perfusion in hepatic diffuse disease.
abstract: OBJECTIVE
  To investigate the changes and contributions of superior mesenteric venous perfusion (SMVP) and splenic venous perfusion (SpVP) to portal venous CT perfusion in canine model of hepatic diffuse disease.
  
  
  METHODS
  By selective catheterization in superior mesenteric and splenic arteries respectively after CT perfusion scanning, SMVP and SpVP became available. Sixteen dogs were adopted and induced by carbon tetrachloride after data under normal conditions were collected. After 3, 6, 9 and 12 months from carbon tetrachloride intervention, liver biopsies by puncture or operation were performed after CT perfusion scanning. SMVP and SpVP under different pathologic conditions were compared and analyzed.
  
  
  RESULTS
  Three stages of hepatic diffuse lesions were defined according to pathologic changes, namely hepatitis, hepatic fibrosis, and cirrhosis. The number of dogs which survived from each stage was: 16 from normal, 12 from hepatitis, 10 from hepatic fibrosis and 4 from cirrhosis. During this progressive period, SpVP ml/(min·100 ml) declined slightly, but there were no significant differences between different stages (P > 0.05). SMVP ml/(min·100 ml) in stage of normal (64.1 ± 8.1) and hepatic fibrosis (44.4 ± 4.5), normal and cirrhosis (42.6 ± 5.4), hepatitis (61.3 ± 6.4) and hepatic fibrosis, hepatitis and cirrhosis was significantly different, but there was no significant difference of SMVP between normal and hepatitis (P = 0.326) or hepatic fibrosis and cirrhosis (P = 0.668).
  
  
  CONCLUSIONS
  With our evidence of interventional CT perfusion, it is mesenteric, not splenic, perfusion that might coincide with hepatic portal venous perfusion during the progressive period of hepatic diffuse disease.
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Hongzan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Zaiming
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xin
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Guo
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D004285:Dogs; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000473:pathology; D008642:Mesenteric Veins / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D013162:Splenic Vein / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D002251:Carbon Tetrachloride
keywords: Portal venous perfusion; computed tomography; hepatic diffuse disease