title: Chromatin Interaction Analysis with Paired-End Tag (ChIA-PET) sequencing technology and application.
abstract: BACKGROUND
  Long-range chromatin interactions play an important role in transcription regulation. Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET) is an emerging technology that has unique advantages in chromatin interaction analysis, and thus provides insight into the study of transcription regulation.
  
  
  RESULTS
  This article introduces the experimental protocol and data analysis process of ChIA-PET, as well as discusses some applications using this technology. It also unveils the direction of future studies based on this technology.
  
  
  CONCLUSIONS
  Overall we show that ChIA-PET is the cornerstone to explore the three-dimensional (3D) chromatin structure, and certainly will lead the forthcoming wave of 3D genomics studies.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Li
authors.forename: Liuyang
authors.initials: L
authors.lastname: Cai
authors.forename: Huidan
authors.initials: H
authors.lastname: Chang
authors.forename: Ping
authors.initials: P
authors.lastname: Hong
authors.forename: Qiangwei
authors.initials: Q
authors.lastname: Zhou
authors.forename: Ekaterina V
authors.initials: EV
authors.lastname: Kulakova
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Kolchanov
authors.forename: Yijun
authors.initials: Y
authors.lastname: Ruan
mesh_terms: D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism*; D023281:Genomics; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D014157:Transcription Factors