title: The Relationship between P-Selectin Polymorphisms and Thrombosis in Antiphospholipid Syndrome: A Pilot Case-Control Study.
abstract: OBJECTIVE
  The selectins are cell adhesion molecules that mediate the interactions among leukocytes, activated platelets, and endothelial cells. We aimed to investigate whether P-selectin polymorphisms are associated with thrombosis in patients with antiphospholipid syndrome (APS).
  
  
  METHODS
  The diagnosis and classification of APS were based on the report of an international workshop. Genomic DNA was extracted from citrated blood samples of all subjects. Three single nucleotide polymorphisms associated with the P-selectin coding region (S290N, c.1087G>A; N562D, c.1902G>A; T715P, c.2363A>C) were assessed.
  
  
  RESULTS
  There were 26 APS (65%) patients with thrombosis. The number of patients without thrombosis was 14 (35%). The frequency of the N562D-DN genotype was significantly higher in patients with APS than in healthy controls (p=0.003). The frequency of this genotype was significantly higher in patients with APS with thrombosis compared with patients with no thrombosis (p=0.03). The N562D-NN genotype was found at a higher frequency in patients with APS than in healthy controls (p=0.004).
  
  
  CONCLUSIONS
  Our results suggest that the N562D polymorphism of the DN genotype of P-selectin is associated with an increased risk of thrombosis in patients with APS.
authors.affiliation: İstanbul University İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey. E-ma-il: nalpay@istanbul.edu.tr.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Alpay
authors.forename: Veysel Sabri
authors.initials: VS
authors.lastname: Hançer
authors.forename: Burak
authors.initials: B
authors.lastname: Erer
authors.forename: Murat
authors.initials: M
authors.lastname: İnanç
authors.forename: Reyhan
authors.initials: R
authors.lastname: Diz-Küçükkaya