title: Role of interleukin-22 in inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by the microbiota of the intestinal lumen and inappropriate immune responses. Aberrant immune responses can cause secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract, leading to further inflammation. Interleukin (IL)-22 is a member of the IL-10 family of cytokines that was recently discovered to be mainly produced by both adaptive and innate immune cells. Several cytokines and many of the transcriptional factors and T regulatory cells are known to regulate IL-22 expression through activation of signal transducer and activator of transcription 3 signaling cascades. This cytokine induces antimicrobial molecules and proliferative and antiapoptotic pathways, which help prevent tissue damage and aid in its repair. All of these processes play a beneficial role in IBD by enhancing intestinal barrier integrity and epithelial innate immunity. In this review, we discuss recent progress in the involvement of IL-22 in the pathogenesis of IBD, as well as its therapeutic potential.
authors.affiliation: Lin-Jing Li, Chen Gong, Mei-Hua Zhao, Bai-Sui Feng, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
authors.forename: Lin-Jing
authors.initials: LJ
authors.lastname: Li
authors.affiliation: Lin-Jing Li, Chen Gong, Mei-Hua Zhao, Bai-Sui Feng, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gong
authors.affiliation: Lin-Jing Li, Chen Gong, Mei-Hua Zhao, Bai-Sui Feng, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Zhao
authors.affiliation: Lin-Jing Li, Chen Gong, Mei-Hua Zhao, Bai-Sui Feng, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
authors.forename: Bai-Sui
authors.initials: BS
authors.lastname: Feng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D049109:Cell Proliferation; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D007378:Interleukins / Q000276:immunology / Q000378:metabolism* / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D010539:Permeability; D015398:Signal Transduction; D014945:Wound Healing; D000097043:Interleukin-22
chemical_list: D000893:Anti-Inflammatory Agents; D007378:Interleukins; D000097043:Interleukin-22
keywords: Inflammatory bowel disease; Interleukin-22; Signal transducer and activator of transcription 3