title: Intrathoracic Castleman disease.
abstract: OBJECTIVE
  To analyze patients with Castleman disease who were diagnosed by surgery.
  
  
  METHODS
  We retrospectively investigated the postoperative pathological records of operations performed between January 1992 and December 2012 in our hospital. Files of 19 patients with the diagnosis of Castleman disease were analyzed.
  
  
  RESULTS
  There were 13 male and 6 female patients with a mean age of 40.1 + 11.4 (range: 20-57) years. Fifteen thoracotomies and 3 video-assisted thoracoscopies, 12 on the right side and 6 on the left side, and 1 mediastinoscopy were performed. Biopsies and mass excisions were performed in 2 and 17 cases, respectively. Histopathological findings were hyaline vascular-type (n = 16), plasma cellular- type (n = 2), and hyaline vascular plus plasma cellular-type (n = 1) Castleman disease.
  
  
  CONCLUSIONS
  Castleman disease can occur in all areas of the thorax, but the mediastinum and hilum are the most common locations. Surgical excision is the best method of diagnosis and treatment. Complete excision is curative for local forms of the disease. However, complete excision may not be possible at all times due to local invasion and hypervascularization. Multimodal treatment, including chemotherapy, is recommended in patients with a multicentric form of the disease, and they should be followed closely.
authors.forename: Pinar
authors.initials: P
authors.lastname: Biçakçioğlu
authors.forename: Selim Şakir Erkmen
authors.initials: SŞ
authors.lastname: Gülhan
authors.forename: Leyla Nesrin
authors.initials: LN
authors.lastname: Acar
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Ağaçkiran
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Özkara
authors.forename: Sadi
authors.initials: S
authors.lastname: Kaya
authors.forename: Nurettin
authors.initials: N
authors.lastname: Karaoğlanoğlu
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008481:Mediastinoscopy; D008875:Middle Aged; D012189:Retrospective Studies; D013896:Thoracic Diseases / Q000473:pathology* / Q000601:surgery*; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D055815:Young Adult