title: SOX10 expression in a gangliocytic paraganglioma--a case report.
abstract: We present a case of a 49-year-old woman who underwent a pancreaticoduodenectomy for symptomatic treatment of an obstructive periampullary duodenal mass initially found on CT imaging. Histologically, the tumor showed a triphasic pattern including small round cells, a spindle-cell component and ganglion cells of varying size. Furthermore, the tumor was surrounded by a proliferation of pancreatic ducts. These features led to the diagnosis of a gangliocytic paraganglioma arising in an ectopic pancreas. Sections of the tumor were then stained for SOX10, a neural crest transcription factor, and it was shown to be positive in the ganglion cells. The exact origin of gangliocytic paragangliomas has not yet been clearly defined. However, this finding of aberrant expression of SOX10 supports the idea of these lesions being neoplastic in nature.
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, USA. Electronic address: npeterlau@gmail.com.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Lau
authors.affiliation: Department of Surgery, Harbor-UCLA Medical Center, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Hari
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: French
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D004379:Duodenal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D016577:Pancreaticoduodenectomy; D010235:Paraganglioma / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D055757:SOXE Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C527923:SOX10 protein, human; D055757:SOXE Transcription Factors
keywords: Gangliocytic paraganglioma; SOX10