title: New insights into innate immune restriction of West Nile virus infection.
abstract: West Nile virus (WNV) is an encephalitic flavivirus that has provided a valuable experimental system for studying viral pathogenesis and immunity. Although in vitro approaches and mouse models of infection have identified pattern recognition receptor and interferon pathways that control WNV infection, our appreciation of specific antiviral effectors has been more limited. In this review, we highlight recent advances in our understanding of the host factors that restrict WNV infection in mammals and insects, especially those resulting from large-scale screening approaches.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Lazear
authors.affiliation: Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D007313:Insecta; D008322:Mammals; D008954:Models, Biological; D014779:Virus Replication; D014902:West Nile virus / Q000276:immunology* / Q000502:physiology*