title: Three new compounds isolated from the seeds of Vaccaria segetalis.
abstract: Two new capsaicin analogs, N-(3-methoxy-4-hydroxyphenethyl)-tetracosanamide (1) and N-(3,4-dihydroxyphenethyl)-tetracosanamide (2), along with one new flavonoidal glycoside pinnatifin E (3) were isolated from the ethanolic extract of the seeds of Vaccaria segetalis. Their structures were elucidated on the basis of spectroscopic methods including 1D, 2D NMR, MS, and other spectroscopic techniques, as well as by comparison with the relevant literatures. All compounds were evaluated for their coagulation Factor Xa inhibition activities.
authors.affiliation: a School of Pharmacy, Hainan Medical University , Haikou 571101 , China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Li-Long
authors.initials: LL
authors.lastname: Jiang
authors.forename: Tong-Shu
authors.initials: TS
authors.lastname: Xiao
authors.forename: Shou-Qian
authors.initials: SQ
authors.lastname: Chen
authors.forename: You-Bin
authors.initials: YB
authors.lastname: Li
mesh_terms: D002211:Capsaicin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015951:Factor Xa / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry; D031245:Vaccaria / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; C000602160:N-(3,4-dihydroxyphenethyl)-tetracosanamide; C000602159:N-(3-methoxy-4-hydroxyphenethyl)-tetracosanamide; C000602162:pinnatifin E; D015951:Factor Xa; D002211:Capsaicin
keywords: FXa inhibition activity; N-(3,4-dihydroxyphenethyl)-tetracosanamide; N-(3-methoxy-4-hydroxyphenethyl)-tetracosanamide; Vaccaria segetalis; pinnatifin E