title: Trogopterins A-C: Three new neolignans from feces of Trogopterus xanthipes.
abstract: Seven compounds, including three neolignans 1-3, a norlignan 4, and three diterpenoids 5-7, were isolated from the feces of Trogopterus xanthipes. Structures of these compounds were identified by 1D and 2D NMR as well as MS. The absolute configurations of compounds 1, 2, and 4 were determined by comparing CD spectra and optical rotations. Among the isolated compounds, 1-3 were novel and subsequently named trogopterins A, B, and C, respectively. Likewise, compound 4 was isolated from nature for the first time. Cytotoxic activities of compounds 1-4 were evaluated. Compounds 1-3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 34.77-45.68 μM.
authors.affiliation: School of Biotechnology, Yeungnam University, Daedong, Gyeongsan, Gyeongbuk 712-749, South Korea.
authors.forename: Soyoon
authors.initials: S
authors.lastname: Baek
authors.affiliation: School of Biotechnology, Yeungnam University, Daedong, Gyeongsan, Gyeongbuk 712-749, South Korea.|Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, P. R. China.
authors.forename: Xuikui
authors.initials: X
authors.lastname: Xia
authors.affiliation: College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Gyeongsan, Gyeongbuk 712-702, South Korea.
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.affiliation: Department of Marine Biology & Aquaculture, Gyeongsang National University, Tongyeong, Gyeongnam 650-160, South Korea.
authors.forename: Chanil
authors.initials: C
authors.lastname: Park
authors.affiliation: School of Biotechnology, Yeungnam University, Daedong, Gyeongsan, Gyeongbuk 712-749, South Korea.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Shim
keywords: Trogopterus xanthipes; cytotoxic activity; neolignans