title: Multiparametric pelvic MRI accuracy in diagnosing clinically significant prostate cancer in the reevaluation of biopsy microfocal tumor.
abstract: OBJECTIVE
  To evaluate the accuracy of multi-parametric pelvic magnetic resonance imaging (mpMRI) in diagnosing prostate cancer (PCa) in men with initial biopsy microfocal cancer.
  
  
  METHODS
  From January 2012 to July 2014, 40 patients before undergoing repeat transperineal saturation prostate biopsy (SPBx; median, 28 cores) for the presence of a microfocal PCa were submitted to 3.0-Tesla mpMRI.
  
  
  RESULTS
  A T1c clinical stage PCa was found in 23 (57.5%) patients submitted to SPBx; mpMRI was positive in 16/40 (40%) cases and in 11 of them a clinically significant PCa was found. On the contrary, the 12 men with negative mpMRI had a quantitative histology suitable for clinically insignificant cancer. Diagnostic accuracy of mpMRI in diagnosing significant PCa was equal to 100%.
  
  
  CONCLUSIONS
  Multi-parametric pMRI should be suggested in the re-evaluation of microfocal cancer as a selection approach of patients at risk for clinically significant PCa.
authors.affiliation: Urology Unit, Cannizzaro Hospital, Catania, Italy piepepe@hotmail.com.
authors.forename: Pietro
authors.initials: P
authors.lastname: Pepe
authors.affiliation: Urology Unit, Cannizzaro Hospital, Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Dibenedetto
authors.affiliation: Imaging Department, Cannizzaro Hospital, Catania, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Garufi
authors.affiliation: Imaging Department, Cannizzaro Hospital, Catania, Italy.
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Priolo
authors.affiliation: Urology Unit, Cannizzaro Hospital, Catania, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Pennisi
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000473:pathology; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
keywords: Prostate cancer; microfocal prostate cancer; multi-parametric MRI