title: Constitutively active AR-V7 plays an essential role in the development and progression of castration-resistant prostate cancer.
abstract: This study aimed to investigate the role of AR-V7 in development of castration-resistant prostate cancer (CRPC) and to determine whether the AR-V7 expression in CRPC tissues can predict cancer-specific survival. We enrolled 100 localized prostate cancer (PCa) (cohort 1), 104 newly diagnosed metastatic PCa (cohort 2), and 46 CRPC (cohort 3) patients treated at our institution. The expression of AR-V7 in PCa was assessed by immunohistochemistry. Cox regression models were used to evaluate the predictive role of all covariates for the development of CRPC in cohort 2 and for cancer-specific survival in cohort 3. Time to CRPC and cancer-specific survival curves were estimated using the Kaplan-Meier method. AR-V7 expression rate in cohort 3 was significantly elevated compared with other two cohorts (p < 0.001). Multivariate analysis revealed that AR-V7 was an independent predictive factor for CRPC development (HR = 2.627, p = 0.001) and for cancer specific survival (HR = 2.247, p = 0.033). Furthermore, the AR-V7 expression was associated with shorter survival in CRPC patients. Our results demonstrated protein AR-V7 levels in primary tumors can be used as a predictive marker for the development of CRPC and as a prognostic factor in CRPC patients. Therapy targeting AR-V7 may help prevent PCa progression and improve the prognosis of CRPC patients.
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Qu
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Dai
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Dingwei
authors.initials: D
authors.lastname: Ye
authors.affiliation: 1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China [2] Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
authors.forename: Yunyi
authors.initials: Y
authors.lastname: Kong
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Chang
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Jia
authors.affiliation: 1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China [2] Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Yang
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Hailiang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Guohai
authors.initials: G
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D064129:Prostatic Neoplasms, Castration-Resistant / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen