title: In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer.
abstract: We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs) capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of LiposAu NPs performed in a small animal model indicates in situ degradation in hepatocytes and further getting cleared through the hepato-biliary and renal route. Further, the therapeutic potential of LiposAu NPs tested in mouse tumor xenograft model using NIR laser (750 nm) illumination resulted in complete ablation of the tumor mass, thus prolonging disease-free survival.
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay , Mumbai, India.
authors.forename: Aravind Kumar
authors.initials: AK
authors.lastname: Rengan
authors.forename: Amirali B
authors.initials: AB
authors.lastname: Bukhari
authors.forename: Arpan
authors.initials: A
authors.lastname: Pradhan
authors.forename: Renu
authors.initials: R
authors.lastname: Malhotra
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
authors.forename: Rohit
authors.initials: R
authors.lastname: Srivastava
authors.forename: Abhijit
authors.initials: A
authors.lastname: De
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D006046:Gold / Q000737:chemistry*; D006979:Hyperthermia, Induced; D008081:Liposomes; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy; D023041:Xenograft Model Antitumor Assays
chemical_list: D001672:Biocompatible Materials; D008081:Liposomes; D006046:Gold
keywords: Gold nanoparticles; cancer nanotechnology; liposomes; photothermal therapy; theranostics