title: Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis.
abstract: IL4 -589C/T polymorphism has been implicated in susceptibility to pediatric asthma risk. Several studies investigated the association of this polymorphism with pediatric asthma in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between IL4 -589C/T polymorphism and pediatric asthma risk. Databases including Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wangfang were searched to find relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. A significant association was found between IL4 -589C/T polymorphism and pediatric asthma risk (OR=1.53, 95% CI 1.27-1.85). In the subgroup analyses by ethnicity, the significant association was found among Caucasians (OR=1.70, 95% CI 1.38-2.09) and Asians (OR=1.58, 95% CI 1.23-2.04). Our results suggested that IL4 -589C/T polymorphism conferred a risk factor of pediatric asthma.
authors.affiliation: Pediatrics Department, The First Affiliated Hospital of Zhengzhou University, The Construction East Road No. 1 in Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Suqin
authors.initials: S
authors.lastname: Zhang
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Li
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D002648:Child; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: C508598:IL4 protein, human; D015847:Interleukin-4