title: Calibration-free coronary artery measurements for interventional device sizing using inverse geometry x-ray fluoroscopy:in vivovalidation.
abstract: Proper sizing of interventional devices to match coronary vessel dimensions improves procedural efficiency and therapeutic outcomes. We have developed a method that uses an inverse geometry x-ray fluoroscopy system [scanning beam digital x-ray (SBDX)] to automatically determine vessel dimensions from angiograms without the need for magnification calibration or optimal views. For each frame period (1/15th of a second), SBDX acquires a sequence of narrow beam projections and performs digital tomosynthesis at multiple plane positions. A three-dimensional model of the vessel is reconstructed by localizing the depth of the vessel edges from the tomosynthesis images, and the model is used to calculate the length and diameter in units of millimeters. Thein vivoalgorithm performance was evaluated in a healthy porcine model by comparing end-diastolic length and diameter measurements from SBDX to coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS), respectively. The length error was -0.49 ± 1.76 mm(SBDX- CCTA, mean ± 1 SD). The diameter error was 0.07 ± 0.27 mm (SBDX - minimum IVUS diameter, mean ± 1 SD). Thein vivoagreement between SBDX-based vessel sizing and gold standard techniques supports the feasibility of calibration-free coronary vessel sizing using inverse geometry x-ray fluoroscopy.
authors.affiliation: University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Ave, Madison, Wisconsin 53705, United States.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Tomkowiak
authors.affiliation: University of Wisconsin-Madison, Department of Medicine, 600 Highland Ave, Madison, Wisconsin 53792, United States.
authors.forename: Amish N
authors.initials: AN
authors.lastname: Raval
authors.affiliation: University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Ave, Madison, Wisconsin 53705, United States ; University of Wisconsin-Madison, Department of Medicine, 600 Highland Ave, Madison, Wisconsin 53792, United States.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Van Lysel
authors.affiliation: Triple Ring Technologies, Inc., 39655 Eureka Dr, Newark, California 94560, United States.
authors.forename: Tobias
authors.initials: T
authors.lastname: Funk
authors.affiliation: University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Ave, Madison, Wisconsin 53705, United States ; University of Wisconsin-Madison, Department of Medicine, 600 Highland Ave, Madison, Wisconsin 53792, United States.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Speidel
keywords: cardiac interventions; inverse geometry; quantitative coronary angiography; x-ray fluoroscopy