title: Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties.
abstract: There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.
authors.affiliation: Department of Neurosurgery, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Aras Adem
authors.initials: AA
authors.lastname: Bozkurt
authors.affiliation: Department of Neurosurgery, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Guven
authors.initials: G
authors.lastname: Mustafa
authors.affiliation: Department of Neurosurgery, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Akman
authors.initials: A
authors.lastname: Tarık
authors.affiliation: Department of Neurology, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Adile
authors.affiliation: Department of Neurology, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Sen Halil
authors.initials: SH
authors.lastname: Murat
authors.affiliation: Department of Medical Biochemistry, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Kılıcoglu
authors.initials: K
authors.lastname: Mesut
authors.affiliation: Deparment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Kalkan
authors.initials: K
authors.lastname: Yıldıray
authors.affiliation: Department of Pharmacology, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Silan
authors.initials: S
authors.lastname: Coskun
authors.affiliation: Department of Neurosurgery, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Cosar
authors.initials: C
authors.lastname: Murat
keywords: apoptosis; brain ischemia; inflammatory; nerve regeneration; neural regeneration; neuroprotective effects; oxidative stress; syringaldehyde