title: Inflammatory bowel disease among Bedouin Arabs in southern Israel: urbanization and increasing prevalence rates.
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD) has been associated with genetic and environmental factors, including urban living. IBD was rare in the Israeli Bedouin community 30 years ago. Over recent decades, a large proportion of this community has undergone a transition from a nomadic to a western lifestyle. Our aim was to carry out an updated evaluation of the clinical and epidemiological features of IBD in the Bedouin sector of southern Israel.
  
  
  METHODS
  All Bedouin patients with a known diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) were included in the retrospective study.
  
  
  RESULTS
  The cohort included 31 CD patients and 31 UC patients. The mean age of the patients at diagnosis was 29±10.9 and 35±17.5 years for CD and UC, respectively. The prevalence rate for CD was 15.5/100,000 and the incidence rate was 0.8-3.55/100,000. Fourteen of the CD patients (45%) had ileal disease and 64.5% had inflammatory disease behavior according to the Montreal classification. Eleven of the CD patients (35%) were treated with anti-TNF-α and 26% had undergone surgery. Over the previous decade, the prevalence of UC was 14/100,000 and the incidence was 0.5-2.39/100,000. Eighteen UC patients (58%) had left-sided colitis. Three (9.7%) had undergone total colectomy for severe disease.
  
  
  CONCLUSIONS
  We found an increased prevalence of IBD in the Bedouin population, associated with their change in lifestyle over previous decades. However, the prevalence is still markedly lower than that in other population groups. A high percentage of patients were treated with anti-TNF-α and/or surgery.
authors.affiliation: aThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center and the Faculty of Health Sciences bDepartment of Public Health, Clinical Research Center, Soroka University Medical Center cSurgery Department A, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Naim
authors.initials: N
authors.lastname: Abu Freha
authors.forename: Doron
authors.initials: D
authors.lastname: Schwartz
authors.forename: Jaber
authors.initials: J
authors.lastname: Elkrinawi
authors.forename: Gil
authors.initials: G
authors.lastname: Ben Yakov
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abu Tailakh
authors.forename: Daniela
authors.initials: D
authors.lastname: Munteanu
authors.forename: Abdelrhman
authors.initials: A
authors.lastname: Abu Ganim
authors.forename: Alexander
authors.initials: A
authors.lastname: Fich
mesh_terms: D000328:Adult; D000368:Aged; D018912:Arabs / Q000706:statistics & numerical data*; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000208:ethnology; D003424:Crohn Disease / Q000188:drug therapy / Q000208:ethnology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000208:ethnology*; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012111:Residence Characteristics; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014504:Urban Health / Q000208:ethnology / Q000706:statistics & numerical data / Q000639:trends; D014507:Urbanization / Q000639:trends*
chemical_list: D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha