title: In the right place at the right time: visualizing and understanding mRNA localization.
abstract: The spatial regulation of protein translation is an efficient way to create functional and structural asymmetries in cells. Recent research has furthered our understanding of how individual cells spatially organize protein synthesis, by applying innovative technology to characterize the relationship between mRNAs and their regulatory proteins, single-mRNA trafficking dynamics, physiological effects of abrogating mRNA localization in vivo and for endogenous mRNA labelling. The implementation of new imaging technologies has yielded valuable information on mRNA localization, for example, by observing single molecules in tissues. The emerging movements and localization patterns of mRNAs in morphologically distinct unicellular organisms and in neurons have illuminated shared and specialized mechanisms of mRNA localization, and this information is complemented by transgenic and biochemical techniques that reveal the biological consequences of mRNA mislocalization.
authors.affiliation: 1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3].
authors.forename: Adina R
authors.initials: AR
authors.lastname: Buxbaum
authors.affiliation: 1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3] Department of Molecular Genetics, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel. [4].
authors.forename: Gal
authors.initials: G
authors.lastname: Haimovich
authors.affiliation: 1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3] Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Singer
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger