title: Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome.
abstract: OBJECTIVE
  Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients.
  
  
  METHODS
  We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits.
  
  
  RESULTS
  Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups.
  
  
  CONCLUSIONS
  These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.
authors.affiliation: Department of Biochemistry, Namık Kemal University, Tekirdağ, Turkey. ftulubas@yahoo.com
authors.forename: Feti
authors.initials: F
authors.lastname: Tülübaş
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oran
authors.forename: Rafet
authors.initials: R
authors.lastname: Mete
authors.forename: Filiz
authors.initials: F
authors.lastname: Turan
authors.forename: Ahsen
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Zeynep Deniz
authors.initials: ZD
authors.lastname: Yildiz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gürel
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood* / Q000503:physiopathology; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D018932:Chemokine CCL2; D008263:Macrophage Migration-Inhibitory Factors