title: HLA Correlates of Long-Term Survival in Vertically Infected HIV-1-Positive Adolescents in Harare, Zimbabwe.
abstract: African infants with vertically acquired HIV infection progress rapidly, with only 50% surviving beyond 2 years in the absence of treatment. Despite this high initial mortality, recent reports describe a substantial burden of older children living with untreated vertically acquired HIV infection in Southern Africa. The immunological and genetic factors associated with long-term survival following vertical infection are poorly understood. We performed medium-to-high resolution HLA typing on DNA samples obtained from a cohort of presumed vertically HIV-1-infected children and age-matched uninfected controls in Harare, Zimbabwe. Overall, 93 HLA class I alleles were detected in the study population with a significant enrichment of HLA-C*08:02 and -C*08:04 in the HIV-1-infected long-term survivor group. Conversely, HLA-A*02:01, A*34:02, and -B*58:02 were overrepresented in the uninfected control group. Our data indicate that HLA alleles may have differential effects against HIV acquisition and disease progression in vertical HIV-1 infection.
authors.affiliation: 1 Nuffield Department of Medicine, University of Oxford , Headington, Oxford, United Kingdom .
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Shepherd
authors.forename: Rashida
authors.initials: R
authors.lastname: Ferrand
authors.forename: Shungu
authors.initials: S
authors.lastname: Munyati
authors.forename: Samuel
authors.initials: S
authors.lastname: Folkard
authors.forename: Kathryn
authors.initials: K
authors.lastname: Boyd
authors.forename: Tsitsi
authors.initials: T
authors.lastname: Bandason
authors.forename: Sabelle
authors.initials: S
authors.lastname: Jallow
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Rowland-Jones
authors.forename: Louis-Marie
authors.initials: LM
authors.lastname: Yindom
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D060467:Disease Resistance; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D020276:HIV Long-Term Survivors; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D015030:Zimbabwe
chemical_list: D006680:HLA Antigens