title: A case of metastatic pancreatic adenocarcinoma with prolonged survival after combination of neoadjuvant FOLFIRINOX therapy and synchronous distal pancreatectomy and hepatectomy.
abstract: In this case report we detail the treatment of a patient with pancreatic ductal adenocarcinoma and a solitary liver metastasis who received nine cycles of FOLFIRINOX therapy with favourable response. The patient subsequently underwent synchronous distal pancreatectomy and hepatectomy with an R0 resection followed by three further cycles of FOLFIRINOX. At the last follow-up, 2 years from operation and 28 months from the diagnosis of metastatic pancreatic adenocarcinoma the patient remains disease free.
authors.affiliation: Department of Academic Surgery, Royal Marsden Hospital, London, United Kingdom.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Neofytou
authors.forename: Alexandros
authors.initials: A
authors.lastname: Giakoustidis
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Smyth
authors.forename: David
authors.initials: D
authors.lastname: Cunningham
authors.forename: Satvinder
authors.initials: S
authors.lastname: Mudan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006498:Hepatectomy; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil
keywords: FOLFIRINOX; metastatic pancreatic adenocarcinoma; neoadjuvant; resection; surgery