title: Prodromal Alzheimer's disease presenting as cerebral amyloid angiopathy-related inflammation with spontaneous amyloid-related imaging abnormalities and high cerebrospinal fluid anti-Aβ autoantibodies.
abstract: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
authors.affiliation: Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Giorgio B
authors.initials: GB
authors.lastname: Boncoraglio
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy The inflammatory Cerebral Amyloid Angiopathy and Alzheimer's disease Biomarkers International Network (iCAB) Coordinator.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Piazza
authors.affiliation: Department of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Savoiardo
authors.affiliation: Department of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Farina
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy Department of Neurology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Jacopo C
authors.initials: JC
authors.lastname: DiFrancesco
authors.affiliation: Department of Neurodegenerative Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Prioni
authors.affiliation: Department of Neurodegenerative Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tagliavini
authors.affiliation: Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Eugenio A
authors.initials: EA
authors.lastname: Parati
authors.affiliation: Department of Neurodegenerative Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giaccone
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000150:complications / Q000276:immunology; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D001323:Autoantibodies
keywords: Alzheimer's disease; amyloid-related imaging abnormalities; anti-Aβ autoantibodies; cerebral amyloid angiopathy; cerebral amyloid angiopathy-related inflammation; subarachnoid hemorrhage