title: [Correlation between diffusion tensor imaging and cognitive dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning].
abstract: OBJECTIVE
  To explore the diagnostic value of magnetic resonance (MR) diffusion tensor imaging (DTI) in detecting brain white matter (WM) damage of patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and evaluating their cognitive dysfunction.
  
  
  METHODS
  Thirteen patients with DEACMP and thirteen age- and sex-matched volunteers underwent DTI using 1.5T MR scanner. FA and ADC values of 16 WM regions of interests (ROIs) were measured on DTI by two experienced radiologists independently with double blind methods, cognitive functions were evaluated by another experienced neurologist blinded to patient's medical history using the Montreal cognitive assessment (MoCA). ADC and FA values in DEACMP patients, and their correlations with cognitive dysfunction were analyzed.
  
  
  RESULTS
  ADC values of DEACMP patients increased significantly in all ROIs (P < 0.05) in comparison with the corresponding ROIs of healthy controls, whereas FA values were significantly decreased in all ROIs (P < 0.05) in comparison with that in controls except the bilateral optic radiations, anterior and posterior internal capsules. MoCA scores were positively correlated with FA values of bilateral lower frontal (r(L) = 0.736, P = 0.011; r(R) = 0.762, P = 0.003) lobe, temporal lobe (r(L) = 0.605, P = 0.016; r(R) = 0.559, P = 0.021) and total average WM (r(A) = 0.688, P = 0.001), however it inversely correlated with ADC values of bilateral lower frontal WM (r(L) = -0.674, P = 0.007; r(R) = -0.681, P = 0.019).
  
  
  CONCLUSIONS
  DTI can quantitatively reveal WM microstructure damage of DEACMP patients, indicate the severity of cognitive dysfunctions, and provide important information for pathogenesis and pathological study for DEACMP.
authors.affiliation: Department of neurology, Brain Hospital, Liaocheng People's hospital, 252000, China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Wang
authors.affiliation: E-mail: zhangchuanchen666@163.com.
authors.forename: Chuanchen
authors.initials: C
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiafeng
authors.initials: X
authors.lastname: Yang
authors.forename: Yihua
authors.initials: Y
authors.lastname: Sun
authors.forename: Shuhua
authors.initials: S
authors.lastname: Li
mesh_terms: D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology*; D002249:Carbon Monoxide Poisoning / Q000150:complications*; D003071:Cognition; D003072:Cognition Disorders; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D004311:Double-Blind Method; D006801:Humans; D066127:White Matter / Q000473:pathology*