title: ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis.
abstract: BACKGROUND
  The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis.
  
  
  METHODS
  The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.
  
  
  RESULTS
  A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066-2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).
  
  
  CONCLUSIONS
  The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.
authors.affiliation: Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).
authors.forename: Dewei
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).
authors.forename: Benjie
authors.initials: B
authors.lastname: Wang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D016001:Confidence Intervals; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D005938:Glucocorticoids