title: Recent advances in the study of zebrafish extracellular matrix proteins.
abstract: The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting of numerous proteins that together regulate a variety of cellular and morphogenetic events beginning as early as gastrulation. The zebrafish genome encodes a similar complement of ECM proteins as found in other vertebrate organisms including glycoproteins, fibrous proteins, proteoglycans, glycosaminoglycans, and interacting or modifying proteins such as integrins and matrix metalloproteinases. As a genetic model system combined with its amenability to high-resolution microscopic imaging, the zebrafish allows interrogation of ECM protein structure and function in both the embryo and adult. Accumulating data have identified important roles for zebrafish ECM proteins in processes as diverse as cell polarity, migration, tissue mechanics, organ laterality, muscle contraction, and regeneration. In this review, I highlight recently published data on these topics that demonstrate how the ECM proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis.
authors.affiliation: Department of Biology, Middle Tennessee State University, Murfreesboro, TN 371320, USA. Electronic address: jason.jessen@mtsu.edu.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Jessen
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D005775:Gastrula / Q000196:embryology; D006321:Heart / Q000196:embryology*; D007797:Laminin / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D009432:Neural Crest / Q000196:embryology; D019170:Somites / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007797:Laminin; D003094:Collagen
keywords: Collagen; Extracellular matrix; Fibronectin; Laminin; Morphogenesis; Zebrafish