title: [Systemic sclerosis and occupational exposures: About a case in a driller-powderman].
abstract: BACKGROUND
  Erasmus' syndrome is the association between systemic sclerosis and silica exposure.
  
  
  METHODS
  We report a case of this syndrome in a driller-powderman exposed to silica and nitro compounds contained in explosives.
  
  
  CONCLUSIONS
  Physiopathology and etiologies of systemic sclerosis are still not well known. However, nitric oxide, a product of nitro compounds metabolism, is involved in the physiopathology of the disease: it seems thus licit to wonder about the consequences of an uncontrolled occupational exposure to nitric oxide on the vascular function, already damaged by systemic sclerosis. To a wider extent, our report highlights the importance of a comprehensive and detailed collection of occupational exposures for patients diagnosed with systemic sclerosis.
authors.affiliation: Service de santé au travail et pathologie professionnelle, CHU Côte-de-Nacre, 14033 Caen cedex, France; Institut de recherche et de formation en santé au travail de Basse-Normandie, faculté de médecine de Caen, 14033 Caen cedex, France. Electronic address: mathilde.m.boulanger@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Boulanger
authors.affiliation: Service de médecine interne, CHU Côte-de-Nacre, 14033 Caen cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Bienvenu
authors.affiliation: Service de santé au travail et pathologie professionnelle, CHU Côte-de-Nacre, 14033 Caen cedex, France; Institut de recherche et de formation en santé au travail de Basse-Normandie, faculté de médecine de Caen, 14033 Caen cedex, France.
authors.forename: M-F
authors.initials: MF
authors.lastname: Marquignon
authors.affiliation: Service de santé au travail et pathologie professionnelle, CHU Côte-de-Nacre, 14033 Caen cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Letourneux
authors.affiliation: Service de santé au travail et pathologie professionnelle, CHU Côte-de-Nacre, 14033 Caen cedex, France; Institut de recherche et de formation en santé au travail de Basse-Normandie, faculté de médecine de Caen, 14033 Caen cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Clin
mesh_terms: D053834:Explosive Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009574:Nitro Compounds / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000139:chemically induced*; D012822:Silicon Dioxide / Q000009:adverse effects*
chemical_list: D053834:Explosive Agents; D009574:Nitro Compounds; D012822:Silicon Dioxide
keywords: Diffuse scleroderma; Dérivé nitré; Exposition professionnelle; Nitro compounds; Occupational exposure; Occupational health; Santé au travail; Sclérodermie systémique; Silica; Silice