title: Integrated Ugi-based assembly of functionally, skeletally, and stereochemically diverse 1,4-benzodiazepin-2-ones.
abstract: A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects.
authors.affiliation: Centro Singular de Investigación en Quı́mica Biológica y Materiales Moleculares (CIQUS) and ‡Departamento de Quı́mica Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela , E-15782 Santiago de Compostela, Spain.
authors.forename: Jhonny
authors.initials: J
authors.lastname: Azuaje
authors.forename: José M
authors.initials: JM
authors.lastname: Pérez-Rubio
authors.forename: Vicente
authors.initials: V
authors.lastname: Yaziji
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: El Maatougui
authors.forename: José Carlos
authors.initials: JC
authors.lastname: González-Gomez
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Sánchez-Pedregal
authors.forename: Armando
authors.initials: A
authors.lastname: Navarro-Vázquez
authors.forename: Christian F
authors.initials: CF
authors.lastname: Masaguer
authors.forename: Marta
authors.initials: M
authors.lastname: Teijeira
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
mesh_terms: D001570:Benzodiazepinones / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
chemical_list: D001570:Benzodiazepinones