title: Effect of cold adaptation on activities of relevant enzymes and antioxidant system in rats.
abstract: Exercise in cold environments can cause significant metabolic regulation and antioxidant behavior. For discussing enzymatic responses towards cold adaptation, we investigated enzyme activities of adenylate cyclase (AC) and phosphodiesterase (PDE) in liver, skeletal muscle, and brown adipose tissue (BAT), as well as Na(+)·K(+) ATPase and Na(+)/K(+) ratio in blood. Malondialdehyde (MDA) and superoxide dismutase (SOD) activity in blood were also studied to address the effect of cold adaptation on oxidative damage and antioxidant system. Experimental results indicated that enzyme activities in liver, skeletal muscle and BAT maintained relatively constant for the control group. For the cold adaptation group, enzyme activities in liver and skeletal muscle were in high levels at the beginning, and then gradually decreased to similar values with the control group. However, enzyme activities in BAT performed an increasing trend and significantly higher than the control at the end. In addition, decreased oxidative damage and activated antioxidant system was observed along with the cold adaptation process.
authors.affiliation: Department of Physical Education, Harbin Engineering University Harbin 150001, China.
authors.forename: Ji-Qing
authors.initials: JQ
authors.lastname: Xing
authors.affiliation: Department of Radiology, Harbin Medical University Cancer Hospital Harbin 150081, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Animal Experimental Center, Harbin Medical University Harbin 150081, China.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Chen
authors.affiliation: Department of Physical Education, Harbin Engineering University Harbin 150001, China.
authors.forename: Shang-Bin
authors.initials: SB
authors.lastname: Li
authors.affiliation: Department of Physical Education, Harbin Engineering University Harbin 150001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.affiliation: Department of Physical Education, Harbin Engineering University Harbin 150001, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
keywords: Cold adaptation; Na+·K+ ATPase; adenylate cyclase; malondialdehyde; phosphodiesterase; superoxide dismutase