title: The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis.
abstract: OBJECTIVE
  To determine the relationship between CD28 polymorphisms, rs3116496, and cancer.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  PubMed, EMBASE, Web of Science, and Cochrane library databases were searched to identify studies reporting the association between CD28 polymorphism and cancer. Two authors selected identified studies, extracted, and analyzed the data independently.
  
  
  RESULTS
  Individuals carrying a T allele (TT homozygotes and TT+TC heterozygotes) at rs3116496 had a lower incidence of cancer than carriers of a C allele. Subgroup analysis showed that this association held true for Asians, but not Europeans.
  
  
  CONCLUSIONS
  CD28 polymorphism, rs3116496, contributes to cancer susceptibility in the case of multiple cancers.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Jihae
authors.initials: J
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Kwang Woo
authors.initials: KW
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. Electronic address: hymin@cau.ac.kr.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Min
mesh_terms: D000483:Alleles; D044466:Asian People; D018106:CD28 Antigens / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D039781:PubMed
chemical_list: D018106:CD28 Antigens; D009363:Neoplasm Proteins
keywords: CD28; Cancer; Genetic variants; Meta-analysis; Polymorphism