title: Replication of association of nine susceptibility loci with Graves' disease in the Chinese Han population.
abstract: This study is to evaluate the association of 9 single nucleotide polymorphisms (SNPs) with Graves' disease (GD) in different homogenous samples of the Chinese Han population. A total of 2,865 unrelated individuals were enrolled from Linyi City, Shandong Province, China, including 1,139 patients of GD and 1,726 controls. All 9 SNPs showed significant associations with GD (P < 1.3×10(-4), Bonferroni corrected Pc < 0.001). The most significant association was detected at rs2281388 at the HLA-DPB1 locus (P=1.3×10(-21); OR=1.62, 95% CI: 1.47-1.79). After adjusting for gender and age, 7 SNPs remained significantly associated with GD (P < 3.4×10(-4), Pc < 0.003). The risk of GD caused by any of these SNPs was not significantly different between female and male participants (Phet > 0.15). Four SNPs located in MHC regions were significantly associated with GD in different ages (P < 8.4×10(-4), Pc < 0.04). The risks of any SNP leading to the development of GD did not differ significantly in different ages (P_trend > 0.02, Pc > 0.18). The rs6457617 at the HLA-DR-DQ locus was significantly correlated with gender in GD patients (P=0.004, Pc =0.04). No significant correlation was found between any SNP and age of diagnosis in GD patients (P > 0.02, Pc > 0.17). The 9 previously identified SNPs are associated with GD in the Chinese Han population. And, gender and age may not influence the associations between the 9 SNPs and GD.
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China ; Key Laboratory, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Cuige
authors.initials: C
authors.lastname: Liang
authors.affiliation: Key Laboratory, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Che
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University (SJTU) School of Medicine Shanghai 20025, P. R. China ; Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine Shanghai 20025, P. R. China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Pan
authors.affiliation: Key Laboratory, Linyi People's Hospital Linyi 276000, P. R. China ; State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University (SJTU) School of Medicine Shanghai 20025, P. R. China.
authors.forename: Shuangxia
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China ; Key Laboratory, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Yueli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, Shandong Medical College Linyi 276000, P. R. China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Department of Internal Medicine, Shandong Medical College Linyi 276000, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Lanxia
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University (SJTU) School of Medicine Shanghai 20025, P. R. China ; Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine Shanghai 20025, P. R. China.
authors.forename: Huaidong
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Linyi People's Hospital Linyi 276000, P. R. China ; Key Laboratory, Linyi People's Hospital Linyi 276000, P. R. China.
authors.forename: Guanqi
authors.initials: G
authors.lastname: Gao
keywords: Graves’ disease; age of diagnosis; association; gender; polymorphism