title: Outcome of Multiple Implants and Dissociation of Fluocinolone Acetonide Intravitreal Implant (Retisert) in a Series of 187 Consecutive Implants.
abstract: OBJECTIVE
  To evaluate outcomes of long-term follow-up of Retisert multiple implantation and dissociation in eyes with chronic noninfectious uveitis.
  
  
  METHODS
  Review of 187 consecutive Retisert implants. Outcomes of multiple implantation and spontaneous medication pellet-strut dissociation were evaluated.
  
  
  RESULTS
  A total of 187 consecutive Retisert implants were reviewed. Eight implants were removed. The prevalence of spontaneous dissociation was 2.6% (5/187). The rate of dissociation increased to 11.11% (2/18) in cases of multiple implants. The mean period between Retisert implantation and spontaneous dissociation was 65.05 months. The mean period between implants in the same eye was 55.25 months. In cases of multiple implantations the old implant was not removed and 17.64% (3/17) of eyes required glaucoma filtering surgery.
  
  
  CONCLUSIONS
  The rate of spontaneous dissociation of Retisert medication pellet-strut in eyes with single implant for noninfectious uveitis is low, which tends to increase in eyes with multiple implants.
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .|c Hospital de Olhos Santa Luzia , Recife-PE , Brazil , and.
authors.forename: Clovis Arcoverde
authors.initials: CA
authors.lastname: Freitas-Neto
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .
authors.forename: Armin
authors.initials: A
authors.lastname: Maghsoudlou
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .
authors.forename: Swetha
authors.initials: S
authors.lastname: Dhanireddy
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .
authors.forename: Abhishek
authors.initials: A
authors.lastname: Payal
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .
authors.forename: Sutasinee
authors.initials: S
authors.lastname: Boonsopon
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .
authors.forename: Malinga D
authors.initials: MD
authors.lastname: Ratwatte
authors.affiliation: a Massachusetts Eye Research and Surgery Institution , Cambridge , Massachusetts , USA .|b Ocular Immunology and Uveitis Foundation , Cambridge , Massachusets , USA .|d Harvard Medical School , Cambridge , Massachusetts , USA.
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004343:Drug Implants; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D015864:Panuveitis / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014822:Vitreous Body; D055815:Young Adult
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide
keywords: Chronic noninfectious uveitis; fluocinolone acetonide implant; implant dissociation; multiple implant; retisert