title: Copper-catalyzed enantioselective intramolecular aryl C-N coupling: synthesis of enantioenriched 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamides via an asymmetric desymmetrization strategy.
abstract: The differentiation of two nucleophilic amide groups in malonamides through a copper-catalyzed enantioselective intramolecular aryl C-N coupling reaction is demonstrated based on an asymmetric desymmetrization strategy. Such a method afforded enantioenriched 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamides in high yields and moderate to good enantioselectivity.
authors.affiliation: School of Chemical Engineering and Light Industry, Guangdong University of Technology , No. 100 Waihuan Xi Road Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.
authors.forename: Nian
authors.initials: N
authors.lastname: He
authors.forename: Yanping
authors.initials: Y
authors.lastname: Huo
authors.forename: Jianguang
authors.initials: J
authors.lastname: Liu
authors.forename: Yusha
authors.initials: Y
authors.lastname: Huang
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D011804:Quinolines; D003300:Copper