title: Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models.
abstract: Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology.
authors.affiliation: Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, Mexico.
authors.forename: Noemí
authors.initials: N
authors.lastname: Cárdenas-Rodríguez
authors.affiliation: Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, Mexico.
authors.forename: Elvia
authors.initials: E
authors.lastname: Coballase-Urrutia
authors.affiliation: Laboratory of Neuroplasticity and Neurodegeneration, CINVESTAV, 07360 Mexico City, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Pérez-Cruz
authors.affiliation: Service of Endocrinology, National Institute of Pediatrics, 04530 Mexico City, Mexico.
authors.forename: Hortencia
authors.initials: H
authors.lastname: Montesinos-Correa
authors.affiliation: Laboratory of Pharmacology, National Institute of Pediatrics, 04530 Mexico City, Mexico.
authors.forename: Liliana
authors.initials: L
authors.lastname: Rivera-Espinosa
authors.affiliation: Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, 04150 Mexico City, Mexico.
authors.forename: Aristides
authors.initials: A
authors.lastname: Sampieri
authors.affiliation: Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, Mexico.
authors.forename: Liliana
authors.initials: L
authors.lastname: Carmona-Aparicio
mesh_terms: D000818:Animals; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008962:Models, Theoretical; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D005978:Glutathione