title: [Effects of dioscorea modified pill on cognitive impairment of patients with VCIND: an preliminary study of proton magnetic resonance spectroscopy].
abstract: OBJECTIVE
  To explore the therapeutic effect evaluation of proton magnetic resonance spectroscopy ((1)H-MRS) in patients with vascular cognitive impairment no dementia (VCIND) with dioscorea modified pill.
  
  
  METHODS
  A total of 100 patients with VCIND were randomly assigned into the dioscorea modified pill group (n = 50) and the aricept group (n = 50). And 50 healthy volunteers were recruited as normal group. Each patient was examined with (1)H-MRS and scored with mini-mental state examination (MMSE) and clinical dementia rating (CDR) scale pre- and post-treatment.
  
  
  RESULTS
  After therapy, the NAA/Cr ratios and the itemized scores of cognitive scale compared with that of pre-therapy had significantly difference (P < 0.05) in the dioscorea modified pill group (MMSE (26.5 ± 2.0), CDR(0.14 ± 0.23))vs(MMSE(25.1 ± 2.3), CDR(0.5)). But no difference existed in the aricept group (P > 0.05).
  
  
  CONCLUSIONS
  (1)H-MRS may objectively reflect cognitive dysfunction in VCIND patients. And it has important values in the therapeutic effect evaluation of VCIND with dioscorea modified pill.
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China. Email: whuchenjun@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Zihu
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Hanchao
authors.initials: H
authors.lastname: Lan
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiology, Renmin Hospital of Wuhan University, Hubei 430060, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
mesh_terms: D003071:Cognition; D003072:Cognition Disorders; D015140:Dementia, Vascular; D027742:Dioscorea; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D066244:Proton Magnetic Resonance Spectroscopy