title: Prognostic value of inhibitor of apoptosis protein family expression in patients with acute myeloid leukemia.
abstract: The inhibitor of apoptosis protein (IAP) family acts as an inhibitor of apoptosis pathways. The potential prognostic value of the expression of selected IAP family members, XIAP, cIAP-1, cIAP-2 and survivin protein, was evaluated with regard to treatment response and survival of 56 newly diagnosed adult patients with acute myeloid leukemia (AML). The presence of these IAP members influenced the achievement of a complete response (CR). In addition, overall survival (OS) was influenced by low survivin expression in univariate and multivariate analysis (p = 0.014 and p = 0.013, respectively). A strong correlation was observed between members of the IAP family (XIAP and cIAP-1, XIAP and cIAP-2, cIAP-1 and cIAP-2, p < 0.001 for all comparisons), while Smac/DIABLO demonstrated an inverse correlation with XIAP, cIAP-1 and cIAP-2 (p < 0.001 for all comparisons). Further studies should be undertaken to better demonstrate the mode of action of IAP members, as well as their prognostic and therapeutic potentials.
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pluta
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wierzbowska
authors.affiliation: b Department of Experimental Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cebula-Obrzut
authors.affiliation: c Department of Surgical Oncology , Medical University of Lodz , Lodz , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Pluta
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Stępka
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Szmigielska-Kapłon
authors.affiliation: b Department of Experimental Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Grzybowska-Izydorczyk
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Czemerska
authors.affiliation: b Department of Experimental Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Smolewski
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Wrzesien-Kus
authors.affiliation: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D051017:Apoptosis Regulatory Proteins; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000378:metabolism; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D000077022:Survivin; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins; C107489:BIRC5 protein, human; C412403:DIABLO protein, human; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; D000077022:Survivin; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human
keywords: Acute myeloid leukemia; IAP; apoptosis; prognosis