title: Correlations between peroxisome proliferator activator receptor γ, Cystatin C, or advanced oxidation protein product, and atherosclerosis in diabetes patients.
abstract: We aimed to explore the relationship between peroxisome proliferator activator receptor γ (PPAR γ), Cystatin C or advanced oxidation protein product (AOPP) and atherosclerosis (AS), and identify their diagnostic values for AS. Eighty AS patients above the age of 75 with type 2 diabetes were screened by brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). The baseline level of patients was firstly analyzed, and then the expression of PPAR γ was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Meanwhile, a double-antibody sandwich enzyme-linked immunosorbent assay was performed to analyze the concentration of AOPP, and immunonephelometry was carried out to detect the concentration of Cystatin C. The baseline level of patients was basically consistent. The expression of PPAR γ was significantly higher in severe AS than mild AS patients (P < 0.05), while no differences were found in serum Cystatin C and AOPP between severe AS and mild AS patients (P > 0.05). Thus, PPAR γ exhibited a high diagnostic value for severe AS (AUC = 0.850), but not Cystatin C and AOPP (AUC = 0.553, AUC = 0.4780). Moreover, the combination of PPAR γ, Cystatin C and AOPP exhibited a quite high diagnostic value in AS (AUC = 0.961, Sen = 0.9, Spe = 0.975), which was also higher than PPAR γ alone. In conclusion, the contents of PPAR γ, Cystatin C and AOPP were closely related to AS in diabetes, indicating a potential clinical diagnostic value of PPAR γ, Cystatin C and AOPP in diabetes with AS.
authors.affiliation: The Cadre Health Care Ward, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yang
authors.affiliation: The Cadre Health Care Ward, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China. Electronic address: chunwangdr@163.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: The Cadre Health Care Ward, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China.
authors.forename: Meizi
authors.initials: M
authors.lastname: Guo
authors.affiliation: The Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Feng
authors.affiliation: The Cadre Health Care Ward, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University School, Nanjing 210008, Jiangsu Province, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yin
keywords: Advanced oxidation protein product; Atherosclerosis; Cystatin C; Diabetes; Peroxisome proliferator activator receptor