title: Sclerosis in bisphosphonate-related osteonecrosis of the jaws and its correlation with the clinical stages: study of 43 cases.
abstract: We analysed the degree of sclerosis in the different stages of bisphosphonate-related osteonecrosis of the jaws (BRONJ) and studied the relation between the grade of sclerosis, the clinical symptoms, and the depth of lucency. We compared 43 patients with mandibular BRONJ with a control group of 40 cases with no bony lesions. The presence of sclerotic bone, cortical irregularities, radiolucency, fragmentation or sequestration, periostitis, and narrowing of the mandibular canal were studied from computed tomographic (CT) scans using the program ImageJ 1.47v (National Institute of Health, Bethesda, USA) to measure the radiolucency, width of the cortices, and degree of sclerosis. Patients with BRONJ had more severe sclerosis than controls (p<0.01). There was also a significant difference among the different stages of BRONJ, with the highest values found in stage III (p=0.02). The degree of sclerosis differed according to sex, type of bisphosphonate, and the clinical characteristics such as pain, or suppuration, but not significantly so (p>0.05). We conclude that the degree of sclerosis increases with the clinical stage of BRONJ, and is correlated with the depth of lucency.
authors.affiliation: Oral Medicine, Valencia University, Spain; Department of Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain. Electronic address: bagan@uv.es.
authors.forename: J V
authors.initials: JV
authors.lastname: Bagan
authors.affiliation: Department of Physiology, Valencia University, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Cibrian
authors.affiliation: Department of Physiology, Valencia University, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.affiliation: Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Leopoldo-Rodado
authors.affiliation: Stomatology, University General Hospital, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carbonell
authors.affiliation: Oral Medicine, Valencia University, Spain; University Cardenal Herrera Valencia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Bagán
authors.affiliation: Oral Medicine, Valencia University, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Utrilla
authors.affiliation: University College London [UCL], UK.
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging; D050071:Bone Density Conservation Agents / Q000145:classification; D003751:Dental Fistula / Q000209:etiology; D004164:Diphosphonates / Q000145:classification; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007093:Imidazoles / Q000145:classification; D008297:Male; D008336:Mandibular Diseases / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging; D010024:Osteoporosis / Q000188:drug therapy; D010026:Osteosclerosis / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging; D010147:Pain Measurement / Q000379:methods; D010522:Periostitis / Q000145:classification / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D014081:Tooth Extraction; D000077211:Zoledronic Acid
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: Osteonecrosis of the jaws; Radiographic findings; Sclerosis