title: Parainfluenza virus 5 expressing the G protein of rabies virus protects mice after rabies virus infection.
abstract: Rabies remains a major public health threat around the world. Once symptoms appear, there is no effective treatment to prevent death. In this work, we tested a recombinant parainfluenza virus 5 (PIV5) strain expressing the glycoprotein (G) of rabies (PIV5-G) as a therapy for rabies virus infection: we have found that PIV5-G protected mice as late as 6 days after rabies virus infection. PIV5-G is a promising vaccine for prevention and treatment of rabies virus infection.
authors.affiliation: Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
authors.forename: Junhua
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA zhenfu@uga.edu bhe@uga.edu.
authors.forename: ZhenFang
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA zhenfu@uga.edu bhe@uga.edu.
authors.forename: Biao
authors.initials: B
authors.lastname: He
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D015870:Gene Expression; D005822:Genetic Vectors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D045402:Parainfluenza Virus 5 / Q000235:genetics* / Q000378:metabolism; D011818:Rabies / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D011820:Rabies virus / Q000235:genetics / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014759:Viral Envelope Proteins