title: UV light selectively inhibits spinal cord inflammation and demyelination in experimental autoimmune encephalomyelitis.
abstract: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The incidence of MS is inversely related to sun light exposure or ultraviolet radiation (UVR). UVR was found to suppress experimental autoimmune encephalomyelitis (EAE), an animal model of MS, independent of vitamin D production. The mechanism of this suppression remains to be elucidated. To this end, several elements of an immune response in the spinal cord, spleen and skin during development of EAE were studied. As expected, UVR (10kJ/m(2)) inhibits inflammation and demyelination of the spinal cord. Most significant, UVR dramatically reduced spinal cord chemokine CCL5 mRNA and protein levels. UVR also suppressed IL-10 in skin and spleen but not the spinal cord. As expected from the UVR action on skin, macrophage population and IFN-γ levels are increased in that organ. UVR had no effect on lymphocyte proliferation and IFN-γ in spleen. From these measurements, we suggest that UVR suppression of EAE prevents the migration of inflammatory cells into the CNS by a focal inhibition of chemokine CCL-5 in the CNS and a systemic elevation of immunosuppressive IL-10.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Marling
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.
authors.forename: Emily F
authors.initials: EF
authors.lastname: Beaver
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.
authors.forename: Kyle S
authors.initials: KS
authors.lastname: Severson
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States. Electronic address: deluca@biochem.wisc.edu.
authors.forename: Hector F
authors.initials: HF
authors.lastname: Deluca
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000528:radiation effects; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005786:Gene Expression Regulation / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009186:Myelin Sheath / Q000502:physiology / Q000528:radiation effects*; D009187:Myelitis / Q000150:complications / Q000532:radiotherapy*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy
chemical_list: D015415:Biomarkers; D018946:Chemokine CCL5; D012333:RNA, Messenger
keywords: Chemokine CCL5; IL-10; Multiple sclerosis; Ultraviolet light