title: Acute carbon monoxide poisoning alters hemorheological parameters in human.
abstract: Acute carbon monoxide (CO) poisoning seriously hinders oxygen delivery to tissues. This harmful effect of CO may be aggravated by accompanying changes in the viscosity of blood. We had previously reported increased plasma viscosity in people chronically exposed to CO. This study was planned to test our hypothesis that acute CO poisoning increases blood viscosity. For this purpose four main parameters contributing to blood viscosity - hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity - were determined in patients with acute CO poisoning and compared with healthy controls. Plasma viscosity and erythrocyte aggregation tendency were lower in the CO group (p <  0.05). Erythrocyte deformability was also lower in CO group (p <  0.05). Our results indicate that acute CO poisoning has diverse effects on hemorheological parameters such as attenuating hematocrit value, plasma viscosity, erythrocyte aggregation tendency and erythrocyte deformability.
authors.affiliation: Ankara Numune Education and Research Hospital, Emergency Clinic, Ankara, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Ozturk
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Physiology, Ankara, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Arihan
authors.affiliation: Ankara Education and Research Hospital, Emergency Clinic, Ankara, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Coskun
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Physiology, Ankara, Turkey.
authors.forename: Neslihan H
authors.initials: NH
authors.lastname: Dikmenoglu-Falkmarken
mesh_terms: D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D002249:Carbon Monoxide Poisoning / Q000097:blood*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008297:Male
keywords: Hemorheology; acute carbon monoxide poisoning; erythrocyte aggregation; erythrocyte deformability; hematocrit; plasma viscosity