title: The role of intravitreal trimethoprim/sulfamethoxazole in the treatment of toxoplasma retinochoroiditis.
abstract: The authors evaluate the role of intravitreal trimethoprim/sulfamethoxazole in the treatment of toxoplasma retinochoroiditis (TRC) in four patients. Intravitreal injection of trimethoprim/sulfamethoxazole 1.28 mg/0.08 mL with dexamethasone 400 µg/0.1 mL was injected weekly or biweekly. After the initiation of treatment, a reduction in intraocular inflammation was observed clinically and on optical coherence tomography within 1 week. Three patients regained visual acuity of 20/20, and one patient improved to 20/40 with residual macular scarring. No evidence of retinal toxicity was noted on full-field electroretinogram. Intravitreal trimethoprim/sulfamethoxazole and dexamethasone combination may be an alternative treatment strategy in patients with TRC.
authors.forename: Himadri
authors.initials: H
authors.lastname: Choudhury
authors.forename: Animesh
authors.initials: A
authors.lastname: Jindal
authors.forename: Avinash
authors.initials: A
authors.lastname: Pathengay
authors.forename: Abhishek
authors.initials: A
authors.lastname: Bawdekar
authors.forename: Thomas
authors.initials: T
authors.lastname: Albini
authors.forename: Harry W
authors.initials: HW
authors.lastname: Flynn
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D058449:Intravitreal Injections; D008297:Male; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D003907:Dexamethasone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination