title: Cullins keep autophagy under control.
abstract: Autophagy removes protein aggregates, damaged organelles, and intracellular pathogens from cells and helps to recycle lipids and protein building blocks. However, regulatory mechanisms of the initial, rapid response are largely unknown. In this issue of Developmental Cell, Antonioli et al. (2014) provide mechanistic insights into autophagy induction and termination by Cullin E3 ligases.
authors.affiliation: Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
authors.forename: David G
authors.initials: DG
authors.lastname: McEwan
authors.affiliation: Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, Goethe University, 60438 Frankfurt am Main, Germany; University of Split, School of Medicine, Department of Immunology and Medical Genetics, Soltanska 2, 21 000 Split, Croatia. Electronic address: ivan.dikic@biochem2.de.
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D044842:Cullin Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: C553334:AMBRA1 protein, human; D048868:Adaptor Proteins, Signal Transducing; C521754:Ambra1 protein, mouse; D044842:Cullin Proteins; D044767:Ubiquitin-Protein Ligases