title: Treatment of infections caused by carbapenemase-producing Enterobacteriaceae.
abstract: Treatment of infections caused by carbapenemase-producing Enterobacteriaceae (CPE) is currently one of the most important challenges of infectious diseases. The available information is based on in vitro studies, some animal model data and a few case studies and retrospective cohorts; appropriate data are lacking or are very scarce for some old antibiotics that are still occasionally used. Because of the heterogeneity in clinical situations, in specific carbapenemases and in the susceptibility of isolates, individualized treatment decisions must usually be made. Here we review the different antibiotics that might be useful for treating infections caused by CPE.
authors.affiliation: Unidad Clínica Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain; Departamento de Medicina, Universidad de Sevilla, Sevilla, Spain. Electronic address: jesusrb@us.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Rodríguez-Baño
authors.affiliation: Unidad Clínica Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain; Instituto de Biomedicina de Sevilla, Sevilla, Spain.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Cisneros
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge-CO, Barcelona, Spain.
authors.forename: Carlota
authors.initials: C
authors.lastname: Gudiol
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Clínic, Barcelona, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000145:classification / Q000378:metabolism / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015780:Carbapenems / Q000378:metabolism / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D014943:Global Health; D006801:Humans; D023421:Models, Animal; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Antimicrobial resistance; Antimicrobial therapy; Bacteriemias; Carbapenemasas; Carbapenemases; Enterobacteriaceae Bloodstream infections; Enterobacterias; Multidrug resistance; Multirresistencia; Resistencia a antimicrobianos; Tratamiento antimicrobiano