title: Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer.
abstract: The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Department of Urology, The Second Affiliated Hospital, The Third Military Medical University, Chongqing, China.
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Jiyao
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Urology, The Second Affiliated Hospital, The Third Military Medical University, Chongqing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ye
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Urology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012907:Smoking / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; D012333:RNA, Messenger; C095888:xeroderma pigmentosum group F protein; C086984:XPC protein, human