title: Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: a standard protocol.
abstract: The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations. Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds. Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV. No specific antiviral activity was observed in the cases at hand. Novel compounds were prepared for future biological tests.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Quadrelli
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Naiara
authors.initials: N
authors.lastname: Vazquez Martinez
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Scrocchi
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 8, 95125 Catania, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Corsaro
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 8, 95125 Catania, Italy.
authors.forename: Venerando
authors.initials: V
authors.lastname: Pistarà
mesh_terms: D004267:DNA Viruses / Q000378:metabolism; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D012328:RNA Viruses / Q000378:metabolism
chemical_list: D007555:Isoxazoles; D009705:Nucleosides