title: Study of baicalin on sympathoexcitation induced by myocardial ischemia via P2X3 receptor in superior cervical ganglia.
abstract: After the myocardial ischemia, injured myocardial tissues released large quantity of ATP, which activated P2X3 receptor in superior cervical ganglia and made the SCG postganglionic neurons excited. Excitatory of sympathetic postganglionic efferent neurons increased the blood pressure and heart rates, which aggravated the myocardial ischemic injury. Baicalin has anti-inflammatory and anti-oxidant properties. Our study showed that baicalin reduced the incremental concentration of serum CK-MB, cTn-T, epinephrine and ATP, decreased the up-regulated expression levels of P2X3 mRNA and protein in SCG after MI, and then inhibited the sympathetic excitatory activity triggered by MI injury. These results indicated that baicalin acted on P2X3 receptor was involved in the transmission of sympathetic excitation after the myocardial ischemic injury. Baicalin might decrease sympathetic activity via inhibiting P2X3 receptor in rat SCG to protect the myocardium.
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Shuangmei
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Laboratory Animal, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Guilin
authors.initials: G
authors.lastname: Li
authors.affiliation: Jiangxi University of Finance and Economics, Nanchang, Jiangxi 330006, PR China.
authors.forename: An
authors.initials: A
authors.lastname: Huang
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Lichao
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Song
authors.affiliation: 2012 Grade of Department of Clinical Medicine of Nanchang University, Nanchang 330006, PR China.
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Xie
authors.affiliation: 2012 Grade of Department of Clinical Medicine of Nanchang University, Nanchang 330006, PR China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Lin
authors.affiliation: 2012 Grade of Department of Clinical Medicine of Nanchang University, Nanchang 330006, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.affiliation: 2012 Grade of Department of Clinical Medicine of Nanchang University, Nanchang 330006, PR China.
authors.forename: Shiyao
authors.initials: S
authors.lastname: Wen
authors.affiliation: 2012 Grade of Department of Clinical Medicine of Nanchang University, Nanchang 330006, PR China.
authors.forename: Zhedong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, Information Engineering College of Nanchang University, Nanchang 330006, PR China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China; Institute of Life Science of Nanchang University, Nanchang 330006, PR China. Electronic address: liangsd@hotmail.com.
authors.forename: Shangdong
authors.initials: S
authors.lastname: Liang
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004837:Epinephrine / Q000097:blood; D005419:Flavonoids / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D058920:Purinergic P2X Receptor Antagonists / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D058477:Receptors, Purinergic P2X3 / Q000378:metabolism*; D017783:Superior Cervical Ganglion / Q000187:drug effects* / Q000378:metabolism
chemical_list: D005419:Flavonoids; D058920:Purinergic P2X Receptor Antagonists; D012333:RNA, Messenger; D058477:Receptors, Purinergic P2X3; C038044:baicalin; D000255:Adenosine Triphosphate; D004837:Epinephrine
keywords: Baicalin; P2X(3) receptor; Superior cervical ganglia; Sympathetic activity