title: [Influence of basic thyroid-stimulating hormone levels on outcomes of IVF/ICSI in Qinghai].
abstract: OBJECTIVE
  To study basic thyroid stimulating hormone (bTSH) levels impact on outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in Qinghai.
  
  
  METHODS
  Totally 282 cases with IVF cycles and 93 cases with ICSI cycles were studied prospectively, according to bTSH level, patients were divided into four groups. Reproduction rate, clinical pregnancy rate, miscarriage rate and live birth rate were studied among four groups.
  
  
  RESULTS
  (1) In 375 cases with IVF/ICSI cycles, bTSH was positively correlated with abortion rate (r = 0.42, P = 0.04), but live birth rate and growing rate showed negative correlations with bTSH (r = -0.42, -0.28; P = 0.04, 0.03). bTSH and the number of eggs, the number of fertilized eggs, the number of embryos, biochemical pregnancy rate, and clinical pregnancy rate were no significant correlation (all P > 0.05). (2) Among women at group of ≤ 1.7, >1.7 and ≤ 2.5, >2.5 and ≤ 3.5, >3.5 mU/L, the implantation rates were 28.7%, 27.3%, 37.7% and 19.2%, live birth rates were 80.9%, 75.0%, 82.7%, and 59.8%, abortion rates were 19.0%, 15.0%, 16.7%, 40.1%; they all showed significant difference (all P < 0.05). Abortion rate in women with high bTSH level was higher than that of women with lower bTSH level, however implantation rate, live birth rate in women with high bTSH level were lower.
  
  
  CONCLUSIONS
  When bTSH level is >3.5 mU/L, the abortion rate were increased, but live birth rate, rate of implantation were decreased.
authors.affiliation: Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Shu
authors.affiliation: Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China.
authors.forename: Zhengfang
authors.initials: Z
authors.lastname: Xiong
authors.affiliation: Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China. Email: szzxzxh@126.com.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Dang
mesh_terms: D000022:Abortion, Spontaneous; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin