title: Comparison of Psychotropic Drug Prescribing Quality between Zagreb, Croatia and Sarajevo, B&H.
abstract: BACKGROUND
  The purpose of this paper was to compare outpatient consumption and quality of psychotropic drug prescribing between Croatia and Bosnia & Herzegovina 2006-2010.
  
  
  METHODS
  Data on drug utilization from Zagreb Municipal Pharmacy and Sarajevo Public Pharmacy were used to calculate the number of defined daily doses (DDD) and DDD per 1000 inhabitants per day (DDD/TID) using the WHO Anatomical-Therapeutic-Chemical methodology.
  
  
  RESULTS
  Total utilization of psychopharmaceuticals increased in both cities; however, it was higher in Zagreb than in Sarajevo throughout the study period. The utilization of psycholeptics increased in Zagreb by 2.4% (from 74.5 to 76.3 DDD/TID) and in Sarajevo by 3.8% (from 62.4 to 64.8 DDD/TID). The utilization of anxiolytics decreased in Zagreb by 2.1% and in Sarajevo by even 18.7%. The utilization of antidepressants increased in both cities with predominance of SSRI over TCA utilization, greater in Sarajevo (96.6%) than in Zagreb (10.2%). The anxiolytic/antidepressant ratio decreased by 11.1% in Zagreb (from 2.87 to 2.55) and by 58.7% in Sarajevo (from 5.66 to 2.34). Outpatient utilization of antipsychotics increased significantly in Sarajevo, predominated by typical ones, whereas in Zagreb the utilization of antipsychotics was stable, predominated by atypical ones.
  
  
  CONCLUSIONS
  In Croatia and Bosnia & Herzegovina, there was an obvious tendency to follow western trends in drug prescribing, as demonstrated by the increased use of antidepressants and reduced use of anxiolytics. Despite some improvement observed in the prescribing quality, high use of antipsychotics with dominance of typical antipsychotics in Sarajevo points to the need of prescribing guidelines for antipsychotics.
authors.affiliation: Department of Public Health, Andrija Stampar Teaching Institute of Public Health, Mirogojska cesta 16, HR-10000 Zagreb, Croatia, marina.polic-vizintin@stampar.hr.
authors.forename: Marina
authors.initials: M
authors.lastname: Polić-Vižintin
authors.forename: Danijela
authors.initials: D
authors.lastname: Štimac
authors.forename: Tarik
authors.initials: T
authors.lastname: Čatić
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Šostar
authors.forename: Ana
authors.initials: A
authors.lastname: Zelić
authors.forename: Krešimir
authors.initials: K
authors.lastname: Živković
authors.forename: Pero
authors.initials: P
authors.lastname: Draganić