title: [Correlation of serum 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome in aged males].
abstract: OBJECTIVE
  To explore the association of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) with metabolic syndrome (MS) and its components in aged males.
  
  
  METHODS
  For this cross-sectional study, 1 729 aged males aged over 60 years were selected from participants in a routine annual health examination at our hospital from May to June 2012. Their mean age was 75 ± 10 years. Height, weight, blood pressure, blood glucose, blood lipids, alkaline phosphatase, calcium, phosphorus, 25(OH) D and PTH were measured. And the associations of 25(OH)D and PTH with the presence of MS and its components were analyzed.
  
  
  RESULTS
  The prevalence of MS was 22.0%. The PTH levels were significantly higher in the MS and abnormal blood glucose and HDL-C group than in their control group [(42 ± 16) vs (40 ± 17), (42 ± 16) vs (40 ± 17), (47 ± 18) vs (40 ± 16) ng/L respectively, P < 0.05].However, there were no significant differences of 25(OH)D between these groups. The prevalence of MS showed a gradual increase according to the PTH quintiles (P < 0.05). When comparing the subjects in the highest and lowest quintile of PTH, the former group demonstrated a 1.51-fold increase in odds ratio for MS after adjusting for 25(OH)D levels and other confounding factors. Logistic regression analysis showed that the PTH level was an independent influencing factor for MS in aged males (OR = 1.007, 95%CI: 1.000-1.014, P = 0.047). The levels of 25 (OH) D were not associated with MS in the regression model (OR = 1.004, 95%CI: 0.992-1.016, P = 0.538).
  
  
  CONCLUSIONS
  In aged males, the elevated level of PTH is a risk factor for the prevalence of MS. However, there was no association between 25 (OH) D and MS.
authors.affiliation: Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Xiao
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Email: lichunlin301@163.com.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Li
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Cheng
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Minyan
authors.initials: M
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Pei
authors.forename: Bannuo
authors.initials: B
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
mesh_terms: D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure; D002118:Calcium; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D016017:Odds Ratio; D010281:Parathyroid Hormone; D015995:Prevalence; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives
chemical_list: D001786:Blood Glucose; D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium