title: Therapeutic mesenchymal stromal cells: where we are headed.
abstract: With a range of therapeutic uses, from diabetes and Crohn's disease to wound repair, interest in the function, characterization, and expansion of mesenchymal stromal cells (MSCs) is growing rapidly. When considering the therapeutic use of MSCs, one must take into account a multitude of options including the ideal source of MSCs, the ideal donor, and the best means of expansion. Here we discuss different sources of MSCs, including cord blood, bone marrow, and adipose tissue, the option of using autologous and allogeneic donors, and finally we discuss GMP-applicable expansion protocols aimed at expanding MSCs for clinical use.
authors.affiliation: Program for Cell Enhancement and Technologies for Immunotherapy, Division of Blood and Marrow Transplantation, Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, The George Washington University, Washington, DC, USA, phanley@childrensnational.org.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Hanley
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D064987:Cell- and Tissue-Based Therapy / Q000379:methods / Q000592:standards; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000592:standards; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D016896:Treatment Outcome