title: Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study.
abstract: Genetic variation in DNA repair genes can alter an individual's capacity to repair damaged DNA and influence the risk of cancer. We tested seven polymorphisms in DNA repair genes XRCC1, ERCC2, XRCC3, XRCC2, EXOI and TP53 for a possible association with breast cancer risk in a sample of 672 case and 672 control Russian women. An association was observed for allele A of the polymorphism XRCC1 (R399Q) rs25487 (co-dominant model AA vs. GG: OR 1.76, P = 0.003; additive model OR 1.28, P = 0.005; dominant model: OR 1.29, P = 0.03; recessive model OR 1.63, P = 0.008). Allele T of the polymorphism ERCC2 (D312N) rs1799793 was also associated with breast cancer risk (co-dominant model TT vs. CC: OR 1.43, P = 0.04; additive model OR 1.21, P = 0.02; dominant model: OR 1.30, P = 0.02), but the association became insignificant after applying Bonferroni correction. No association with breast cancer was found for the remaining SNPs. In summary, our study provides evidence that polymorphisms in DNA repair genes may play a role in susceptibility to breast cancer in the population of ethnical Russians.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia. weiner.alexserg@gmail.com.|Novosibirsk State University, Pirogova Street, 2, 630090, Novosibirsk, Russia. weiner.alexserg@gmail.com.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Shadrina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Ermolenko
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.|Novosibirsk State University, Pirogova Street, 2, 630090, Novosibirsk, Russia.
authors.forename: Uljana A
authors.initials: UA
authors.lastname: Boyarskikh
authors.affiliation: Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Sinkina
authors.affiliation: Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
authors.forename: Alexandr F
authors.initials: AF
authors.lastname: Lazarev
authors.affiliation: Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
authors.forename: Valentina D
authors.initials: VD
authors.lastname: Petrova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.|Novosibirsk State University, Pirogova Street, 2, 630090, Novosibirsk, Russia.|Kazan Federal University, Kremlyovskaya street, 18, 420008, Kazan, Republic of Tatarstan, Russia.
authors.forename: Maxim L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012426:Russia / Q000208:ethnology; D044465:White People / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
keywords: Breast cancer; DNA repair; Russian population; SNP