title: [Effect of concomitant chronic kidney disease on the xanthine metabolism in patients with chronic heart failure].
abstract: It is believed that patients with decreased glomerular filtration rate have stronger association between serum uric acid levels and increased risk of cardіоvascular disease. However, it is unclear whether the presence of concomitant chronic kidney disease modifies the xanthine metabolism. The aim of this study was to examine xanthine metabolism violations in chronic heart failure (CHF) patients with concomitant chronic kidney disease (CKD), and evaluate its impact on uric acid levels and xanthine oxidase activity. The study population consisted of 112 patients, aged 72,5±0,98 years. The main group of patients consisted of 72 within CKD patients and the comparison group - of 40 non-CKD participants. We noted high and almost equal detection of xanthine metabolism violations in CHF patients with CKD as well as in non-CKD patients. This data indicate greater severity of the xanthine metabolism violations in patients with concomitant CKD.
authors.forename: M V
authors.initials: MV
authors.lastname: Kolomiets
authors.forename: A V
authors.initials: AV
authors.lastname: Bil'chenko
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D019820:Xanthine / Q000097:blood*
chemical_list: D019820:Xanthine; D014527:Uric Acid