title: Increased expression of miR-24 is associated with acute myeloid leukemia with t(8;21).
abstract: This study was designed to learn the expression status of miR-24 and its clinical relevance in patients with acute myeloid leukemia (AML). We detected the miR-24 expression levels using real-time quantitative PCR in 84 AML patients and investigated the clinical significance of miR-24 expression in AML. There was no difference in clinical parameters between cases with miR-24 high expression and with miR-24 low expression. The frequency of miR-24 high expression was higher in patients with t(8;21) than in others (82% (9/11) versus 44% (32/72), P=0.026). The levels of miR-24 expression had no correlation with the mutations of nine genes (FLT3-ITD, NPM1, C-KIT, IDH1/IDH2, DNMT3A, N/K-RAS and C/EBPA). Meanwhile, among the group who obtained CR, the cases with miR-24 high expression had no difference in overall survival (OS) and relapse-free survival (RFS) than those with miR-24 low expression (P=0.612 and 0.665, respectively). These findings implicated that miR-24 high regulation is a common event in AML with t(8;21), and it might serve as a novel and selective therapeutic target for the treatment of AML with t(8;21).
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Yin
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qian
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Lin
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Wen
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Jing-Dong
authors.initials: JD
authors.lastname: Zhou
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zhu
authors.affiliation: Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Zhao-Qun
authors.initials: ZQ
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D000090243:Nucleophosmin; D011379:Prognosis; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: C543845:MIRN24 microRNA, human; D035683:MicroRNAs; C000716967:NPM1 protein, human; D000090243:Nucleophosmin
keywords: acute myeloid leukemia; miR-24; microRNA