title: Presence of medication taken by blood donors in plasma for transfusion.
abstract: OBJECTIVE
  The TRIP national hemovigilance and biovigilance office receives reports on side-effects and incidents associated with transfusion of labile blood products. Anaphylactic reactions accounted for the largest number of serious transfusion reactions in the period 2008-2012. In most cases, no cause is found for these reactions. TRIP data show that anaphylactic reactions occur relatively frequently with transfusion of plasma or platelet concentrates. Data from blood services show that 10% or more of plasma donors regularly use medication which is permitted under donation guidelines. It is conceivable that medication taken by the donor in plasma for transfusion could cause an anaphylactic transfusion reaction in the recipient. This exploratory study investigated the presence of drugs or drug metabolites in donor plasma.
  
  
  METHODS
  Samples (5 ml) were taken from thawed, quarantine fresh frozen plasma units (FFP) which had to be rejected for transfusion because of leaks or length of time after thawing. The samples were analysed for approximately 1000 drugs and drug metabolites using a toxicological screening method.
  
  
  RESULTS
  Eighty-seven samples were analysed. Toxicological screening was positive in fourteen samples (16%). In eleven samples, one substance was found, and in three samples, the presence of two or three drugs was detected.
  
  
  CONCLUSIONS
  After freezing, storage and thawing of fresh FFP, it is possible to detect medication taken by the donor. Further investigation is recommended to analyse whether donors' medication in plasma can be implicated in some cases of allergic or anaphylactic reactions in transfusion recipients.
authors.affiliation: TRIP National hemovigilance and biovigilance office, Leiden, The Netherlands.
authors.forename: A J W
authors.initials: AJ
authors.lastname: van Tilborgh-de Jong
authors.forename: J C
authors.initials: JC
authors.lastname: Wiersum-Osselton
authors.forename: D J
authors.initials: DJ
authors.lastname: Touw
authors.forename: M R
authors.initials: MR
authors.lastname: Schipperus
mesh_terms: D000328:Adult; D001782:Blood Donors; D058731:Blood Safety / Q000592:standards*; D001803:Blood Transfusion / Q000592:standards; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood*; D010949:Plasma / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations
keywords: allergy; anaphylactic transfusion reaction; donor medication; hemovigilance; plasma