title: Thyroid dysfunction after intra-arterial chemotherapy for hypopharyngeal and laryngeal cancer.
abstract: OBJECTIVE
  Hypothyroidism is a late side effect after curative radiotherapy in the head and neck region. Superselective intra-arterial chemotherapy (SSIAC), when combined with radiation (SSIAC-R), shows higher control potential for locally advanced head and neck cancers, which is attributable to a delivery of higher concentrations of chemotherapeutic agents. However, it could enhance damages in the normal tissues. Hypothyroidism is a late adverse effect after curative radiotherapy in the head and neck region. This study focuses on the toxic effect of treatment modality for thyroid function.
  
  
  METHODS
  A retrospective analysis was performed to examine patients' thyroid function after SSIAC-R for laryngeal and hypopharyngeal cancer.
  
  
  RESULTS
  Hypothyroidism was observed in 21 (77.8%) of 27 patients receiving SSIAC-R, 4 (33.3%) of 12 patients treated with radiation alone, and 7 (41.1%) of 17 who underwent systemic chemoradiotherapy. The number of administered vessels significantly correlated with the incidence of developing hypothyroidism among SSIAC-R treated patients (P=0.03).
  
  
  CONCLUSIONS
  Concurrent setting of SSIAC with radiation significantly raises the possibility of hypothyroidism. Therefore, monitoring late complications of therapeutic procedures is essential during follow-up visits.
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan. Electronic address: endok@med.kanazawa-u.ac.jp.
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Endo
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Masatani
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuji
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Wakisaka
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murono
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D016022:Case-Control Studies; D059248:Chemoradiotherapy / Q000009:adverse effects*; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000628:therapy*; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced* / Q000209:etiology; D007822:Laryngeal Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D013972:Thyrotropin; D002945:Cisplatin; D013974:Thyroxine
keywords: Head and neck squamous cell carcinoma; Health-related quality of life; Hypothyroidism; Intra-arterial chemotherapy; Radiation