title: Resistin predicts ischemia in myocardial perfusion scintigraphy.
abstract: Aim: Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single- photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects.
  
  
  METHODS
  Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed as ischemic or nonischemic. Resistin levels were presented as medians (25th-75th percentiles) and were compared using the Mann-Whitney U test.
  
  
  RESULTS
  Plasma resistin levels were higher in the ischemic group (n = 47) than in the nonischemic group (n = 67) [9.04 pmol/L (6.27-11.8 μmol/L) vs. 3.56 μmol/L (0.39-7.93 pnol/L), respectively; P < 0.001). We showed that plasma resistin levels (OR = 1.26, 95% CI: 1.13-1.41; P < 0.001) and METs (OR = 0.82, 95% CI: 0.70-0.92; P = 0.021) were independent predictors ofischemia. No linear correlation was found between plasma resistin levels and GATED SPECT or stress test parameters.
  
  
  CONCLUSIONS
  Increased baseline resistin levels are independently related to presence of ischemia but are not related to the extent or severity of ischemia, or other functional parameters such as poststress ejection fraction, end systolic, and end diastolic volumes.
authors.affiliation: Department of Nuclear Medicine, Turgut Özal University, Ankara, Turkey. drmustafayildirim@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
authors.forename: Melih Engin
authors.initials: ME
authors.lastname: Erkan
authors.forename: Muhammet
authors.initials: M
authors.lastname: Aşik
authors.forename: Taner
authors.initials: T
authors.lastname: Uçgun
authors.forename: Ayşe
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Huri Tilla
authors.initials: HT
authors.lastname: İlçe
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Aslantaş
authors.forename: Ramazan
authors.initials: R
authors.lastname: Memişoğullari
authors.forename: Serkan
authors.initials: S
authors.lastname: Bulur
authors.forename: Ahmet Semih
authors.initials: AS
authors.lastname: Doğan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D055414:Myocardial Perfusion Imaging / Q000379:methods; D052243:Resistin / Q000097:blood*; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D052243:Resistin; D017256:Technetium Tc 99m Sestamibi