title: Genomic prediction of genetic merit using LD-based haplotypes in the Nordic Holstein population.
abstract: BACKGROUND
  A haplotype approach to genomic prediction using high density data in dairy cattle as an alternative to single-marker methods is presented. With the assumption that haplotypes are in stronger linkage disequilibrium (LD) with quantitative trait loci (QTL) than single markers, this study focuses on the use of haplotype blocks (haploblocks) as explanatory variables for genomic prediction. Haploblocks were built based on the LD between markers, which allowed variable reduction. The haploblocks were then used to predict three economically important traits (milk protein, fertility and mastitis) in the Nordic Holstein population.
  
  
  RESULTS
  The haploblock approach improved prediction accuracy compared with the commonly used individual single nucleotide polymorphism (SNP) approach. Furthermore, using an average LD threshold to define the haploblocks (LD≥0.45 between any two markers) increased the prediction accuracies for all three traits, although the improvement was most significant for milk protein (up to 3.1% improvement in prediction accuracy, compared with the individual SNP approach). Hotelling's t-tests were performed, confirming the improvement in prediction accuracy for milk protein. Because the phenotypic values were in the form of de-regressed proofs, the improved accuracy for milk protein may be due to higher reliability of the data for this trait compared with the reliability of the mastitis and fertility data. Comparisons between best linear unbiased prediction (BLUP) and Bayesian mixture models also indicated that the Bayesian model produced the most accurate predictions in every scenario for the milk protein trait, and in some scenarios for fertility.
  
  
  CONCLUSIONS
  The haploblock approach to genomic prediction is a promising method for genomic selection in animal breeding. Building haploblocks based on LD reduced the number of variables without the loss of information. This method may play an important role in the future genomic prediction involving while genome sequences.
authors.forename: Beatriz C D
authors.initials: BC
authors.lastname: Cuyabano
authors.affiliation: Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Denmark. guosheng.su@agrsci.dk.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Su
authors.forename: Mogens S
authors.initials: MS
authors.lastname: Lund
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D005828:Genetics, Population; D023281:Genomics / Q000379:methods; D006239:Haplotypes; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D015203:Reproducibility of Results