title: Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle.
abstract: In this review we report the recent advances in bioactive system containing pyrazole fused with a five membered heterocycle, covering the time span of the last decade. All of them are represented around the common structure of the pyrazole ring fused with another five membered heterocycle containing the nitrogen, sulfur and oxygen atoms in all their possible combinations. The classification we have used is based in terms of the therapeutic area providing, when possible, some general conclusions on the targets and mechanisms of action as well as the structure-activity relationships of the molecules.
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy. Electronic address: demetrio.raffa@unipa.it.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Raffa
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy. Electronic address: benedetta.maggio@unipa.it.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Maggio
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy.
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: Raimondi
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Cascioferro
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Plescia
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cancemi
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Via Archirafi, 32, 90123 Palermo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Daidone
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011720:Pyrazoles; C031280:pyrazole
keywords: Bioactive system; Pyrazole fused with a five membered heterocycle